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<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9W0</accession>
    <name>A0A1E3H9W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000075">
        <property type="protein sequence ID" value="ODN73084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027741.1">
        <property type="nucleotide sequence ID" value="XM_019180279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9W0"/>
    <dbReference type="GeneID" id="30197524"/>
    <dbReference type="OrthoDB" id="1681765at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF259">
        <property type="entry name" value="OS08G0106900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN73084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="35705" checksum="518BCEF58CEFE559" modified="2017-01-18" version="1" fragment="single">IFRKVLKSITSPDFYGRWVQQPTSETPIDPRLADNPKFYPFFRECVGAIDGTHVPVTVRDISPDAWRDRNGQRSTNVMAACDFSFRFTYVRAGYEGSGNDVNVMENAIEDDFVVPHGRFYLADAGYGAHPGLRVPYRGKRYHLKEWGKAGTRPKNKEELYNLRHAQARNVIERIFGVVKERFSIMKHGSEFSMADQFRTIYAVCVLHNMITTKEGIQRLGEELFPSILNLVAGVYDENDPGHIEEEARGKEEDKLLAKELATNQKLKRGQNTVGLSRYTVRKQADKVRDELAQDMWMQYTSYNARQQLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HDX0</accession>
    <name>A0A1E3HDX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027777.1">
        <property type="nucleotide sequence ID" value="XM_019180247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HDX0"/>
    <dbReference type="GeneID" id="30197492"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN73631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="16148" checksum="B6BB983D2FB472EE" modified="2017-01-18" version="1">MFGISAYGYGLVDNDPAKWKKIQEQGLGGFTGIIPRSDRYRIEDGIKDNVGLHPHNKGEWQYLDRIQGHSEMKRWYGVGHEAEGGHEIGAMVRSLWDERGWECVWFVNPPALQSMPGLSHFHVMARRKTPEEINASEEIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HFL0</accession>
    <name>A0A1E3HFL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000058">
        <property type="protein sequence ID" value="ODN74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027840.1">
        <property type="nucleotide sequence ID" value="XM_019180183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HFL0"/>
    <dbReference type="GeneID" id="30197423"/>
    <dbReference type="OrthoDB" id="10417790at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="200" mass="22449" checksum="9CCCD6616E0CB29A" modified="2017-01-18" version="1">MSNSQQTSEAGPSSTPAAAAAGPSTDILPTDPGAMLLKIVQKTEDGPEEANYRFKEVFRMYKEIMKEIDESRLKEKEISEMGDIASEEELRAAYAKLRKRTFESQSAYTSLLSVASTQLIEVSKCCVDAVTKAAACEDEMVEKLRVLNQKMVSMEEGQARLLKETRSRYVSENRVLKMEAQKLRSQVINLEKELRKAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH42</accession>
    <name>A0A1E3HH42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027908.1">
        <property type="nucleotide sequence ID" value="XM_019180098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH42"/>
    <dbReference type="GeneID" id="30197338"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="409" mass="43170" checksum="F3369D54260ED597" modified="2017-01-18" version="1">MKRTTNKSPAKGKGKQVDRPVKRATVADSNSDDGSFDDESDGEDDGEARKAAQLAALEAHSRALLGLPPLSPPSKPNNPPDDSLDQSSGEEAEDDEGEGEDFESDDGWGAEDGFVSDSEDELAPQLPTTKLKPTAPPTETSNVPVVVFDQPSASSSSTLSKAERRAFLTGNSTKMMGITSTPDYPPSRKRSRQTAEEDDEDTTAASLDKSLHSMLLNSLLPEHAASLASRPVDKRNAMSARLLELANYELPGEGSKVMKTQHLSKHSAKIRTGMVHKQEARDKAKRQEAIESGNNVRGMSSLGEGLKKSGSGSGSGGKGSQRAMMGMETGKKKGMESRKKGDEDRARGLGMGVGRFAGGMLKLTKGEIDGVNGDFERRRESSRGGRGGRGGRGGRGGGGRGGGSRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH55</accession>
    <name>A0A1E3HH55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027921.1">
        <property type="nucleotide sequence ID" value="XM_019180111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH55"/>
    <dbReference type="GeneID" id="30197351"/>
    <dbReference type="OrthoDB" id="10305401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111892" checksum="BACFE3F717F4868D" modified="2017-01-18" version="1">MSALLPLFTQDAYSEVLIGVFDCLALKDVLSLLRVNKFVHTVFKTSSRTQLAHTRRLFSAPATGNYVVDNASGPADQLAALRDRERRLDNLDYSSMKNIRKDAGERLIAFEQGLLIFRARGDGVRVPKRDFDELDSGEGEEEDDVTTAKVARNDPSKSENLDHLSEHPFSEHPHETVADADAEDVKRKWRATHKNLAYSQNFSNGSSIKDGWDVYRVPEAASDEDSQARGGTIDQGLWCWRTRVRDDLQTVEMCGHDDLMAVIQRGAYFIDRDDPSKLNLSIRISFFSALPPRGTPTPVTGYFAPIPHPEAALPFIDINFNFAEKDVKTDVTDDVKLEVMFGYYGQMSVLVRYGPKTLFAGVWDWKNGVCLGSIPIEDNQTVASLNASGPFAITGSARHVPGSKHQDVYDLAIRMIPLPQAAIPDWREGFVQLSFDTYLLFPPSLGYPPVKPKPDSNPFAPPYPEQACSWFISDIPKVIPVCIFELPIPDLLPWTLAVWYQTHIFGILNFAYSPEVHNAETIGIFTWMLWERKHMSDLSYMLRQATNLALKSLVGRVIHGNDSRRINKYGPLIPASHQASTDIAEGVSWVSTIMVHANRVSEDGTWRNTEGVIIPSQTPSKKPAYIRASSHFADTDWLFTRGLALPSVDITVPTVSYLDWDGANQMRVDFYETVSAAYGAREVRLVPLIEEDGVEDRVLCLSMSDYNPSTLPAAKLSLRQVLGNRRRNIEAQPWYSLDSTIGVEYLPVTFERYRLVRECCVDLQLEYFHIESSLAGLESSLSRIYEGMREEEKALQYESTAKLQRLKERLDKVVAEYQLARNDLDKLRPMEKSDWEEEIEDDLASSSGSSTAADEKGPIDGSEREISKGKKGRSTDIAGSEAAPHAAVPPPPYLTLALAPPTAPTSSSSALDSLPESPSQQATSHSSARAFLPSYSSGLPSHLQEYYQQSWRSEGGLFCRKGKEMLLVAPSCDDAFPDVYFDGRTMLLSGFTPYDYHILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HHL3</accession>
    <name>A0A1E3HHL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000058">
        <property type="protein sequence ID" value="ODN74901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027836.1">
        <property type="nucleotide sequence ID" value="XM_019180179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HHL3"/>
    <dbReference type="GeneID" id="30197419"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="655"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN74901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1081" mass="116502" checksum="1C0ACD9BC7397190" modified="2017-01-18" version="1">MTLPPSALPLSARSPSPPAPSESFLSDLDGTAPSLIETSPGTHDAIWAQPKDASGLNLVSWKYGVDAEAGDGVEKRGFNAISGVLAHPTKRANPLRSSRQPLPPLQPPPPLPKPPPPASYDAYLSSITPLYESFVASQAVSKAAGAGGELDARSPAPLHDLPPLDSVPDIFFDPSFSLSDPSIWSQLSASPSTSSAPDSGVQAALSSHLDTLERHLIHEITLRTPSFFSALTNLQDLHSESTSCLTHITSLQTSLKSVGSTQSSRGLQIINAQEELRGLKEVRGGVEALGEVEEMYGMADKLVEEGDWEGGLGCVEDVVRWWTRYDPLSGESLPLSTLPALASLPTTITNLITKTSHHLSSSLASYLTSLLSRPLDQPPREQELRGSLAPMLEGLLKCGKAGGVEGIWREVVTAAVREESRKWLPGSEEDGVKNPDARGASLAQSLQGLEHEQFMELCDKMYGALLARLTSVKTIGGVMEEIISSSNSITPISISSFPPDSRPLTPLTLTLSETLASSSELAHTRISKILSVRSDPHALLPLPSFLHLYTTTTSFITSTESLSGKSATPLRGVLNAQARGFVQRYHQERLTSSARAVEEEVWTQVDVARGVQRVVELIVQAGMEDPAECFIPPKTTIAAEDAEDKTTTKQLAVEDQKYCLVKATAESLLLLGDYLKIVVNLESVVTDVMSRIIEFLKSFNSRTCQVVLGAGAMRSAGLKNITAKHLALASQSLSVIVSLIPYIREFVRRHLGERQAIMLVEFDKLKRDYQEHQNEIHAKLVAIMSDRLAVHCASLREIKWESTPTKEGPNSYAEMLVKESATLHKVLSKYVSSSTVEHVMGDVIEAIARRLSEEFGKVELKSEEARKRMLHDVAIISIRLKPLSDRGQEIVQLENAVRSKTTPMKTAPVEVEKKVEEKTTEIGGSEKGSDEEKKDNGEGGAEEVVEKKEETSTALSTETPSSPSPPTPPKPNSPSPATPSKEDPPSEAPPAPPKSASPPPPSPPSRPAASLPTDDAEVTNGSAAEKSEETTVSGEAASVVLEEVKGDAGGKKEDGKEQEAEVTEKVEEEEDKTEDEKAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HXK6</accession>
    <name>A0A1E3HXK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028215.1">
        <property type="nucleotide sequence ID" value="XM_019179793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HXK6"/>
    <dbReference type="GeneID" id="30197021"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN80311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="855" mass="92862" checksum="3C13345B8E41FE01" modified="2017-01-18" version="1">MAHEGPSTQTSGSFAVPQPVNQFSVSRNPLSGILSSIRGVTAVGPAANPPIAAATPSHAGSASHKGKAPAAPPSSQSSVHSAYPSGLGHPGNRGFEGPLRLVPFDLRIPNDYPNSFTINPYKAVNQFLMGSFWTDCYPTILNERGFQTFHIVRYLQKFYVDPETVVYPTSWNTTVNFQQTPFYISLAKKFTDLKIVQALRNHATESKLQQLLKRPKRSSQAPSQAPSHDPSQAPSQAPSQAPSQAPSPAPSQGASQAPSPLPSKKLGGLEPDVCLTGYHIGGIAKGTQPTDGRELNHDNKPQRVLYALIEDKWEPWLGKSQLSLHLAGLRYANAEAISQTIYYSLIGYELSKCRSAMAWVNGDFTRILNLCDLVPEGEEVGLESVTMGGGGGRTILVEADSALVGKLRYHRHDCLSAEQFGALVTGEHFIGIPWKVPNSLIANYENWALDLKAKERLDATVYMNLALATHHPETVPDPPIDNRSRENVMDVNPSEEEAHQWRKVSERMQGRRQTRKASIKKAASAVNAAVSDTRNQVVGEEEDEEREDEEGEDEEEKDKQGGNRRDEDDRNPDGRPDGPGGGAPGPGGGASGTDNGSGDHPPSGRRSIRSTRARSDNGQEPSSKRQKRADVSGPTDNLPPSPISMIATSTPSPVSFPTICSLFKIEQPVNVKKWCLSIKQEALTDHTFVNTAIGPNPVIYTDAEKVLPRGYWTHAEYLDHFSELGVSFVLATPLEVDVLLSRAAKFGWGGALGRGFSRLGFPSYLRRKDRSNTTGTENYGAALFYTAHTQSTTYALLKSYLLHRLYTVPPPLNLPPTSPDTVSAPVIVGPTKFPFNHPANVLDGDAVMIPSGWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I137</accession>
    <name>A0A1E3I137_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028267.1">
        <property type="nucleotide sequence ID" value="XM_019179720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I137"/>
    <dbReference type="GeneID" id="30196943"/>
    <dbReference type="OrthoDB" id="10565547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="23500" checksum="5B4670CCA31D8116" modified="2017-01-18" version="1">MQPNQSPASGAPPSSLAKRTTGAAGTSAGSLNPTLHNTRGAAKAGRTLAATESETPEAGFSLGDKGKEREDANSDSTAQAAPVPHTSNSTGDTIPSINITPLGDAPEPLLPQTPSSQINSAPPAHTAADTTGIPIFDANLQAAIEASLLSKFTEMLKASQATAPLVDPTSKPPGLENPTYPGTVPVNDTPQAKPFPSYDELHDVSCQLNQASEERDRGWNSVKDLNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I3C1</accession>
    <name>A0A1E3I3C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028296.1">
        <property type="nucleotide sequence ID" value="XM_019179749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I3C1"/>
    <dbReference type="GeneID" id="30196972"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="34800" checksum="AE4C72B2F5CCC001" modified="2017-01-18" version="1">MSANDDVDAWVAQLMQCKPLSEPEVKKLCDKAREVLMEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKLRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNNNNGLTLVARAHQLVMEGFAWSQDRNVVTIFSAPNYCYRCGNQAAILEVDDALKYTFLQFDPAPRAGEPLVTRRPPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5G9</accession>
    <name>A0A1E3I5G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028364.1">
        <property type="nucleotide sequence ID" value="XM_019179676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5G9"/>
    <dbReference type="GeneID" id="30196899"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="22152" checksum="C37850EAFAC01C03" modified="2017-01-18" version="1">MKSPELLELTASEPLSLEEEYEMQRKWLLDEDKLTFILLARPSPPSDSSTDSSRYILLPEEIQKCRMVGDVNLFLPDGRESEGECEIMIASKEDRRKGYAVEALSLFLKYTTSSLHLPAPQLLSRIGSENIPSIRLFKKLGFGVVKYVKVFDEVEMRFGQGDVEGLDLDFGVVEKGKEVDWEGVALEGRVGVYEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7Z0</accession>
    <name>A0A1E3I7Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028411.1">
        <property type="nucleotide sequence ID" value="XM_019179643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7Z0"/>
    <dbReference type="GeneID" id="30196866"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="254"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42142" checksum="250F0DEC96647381" modified="2017-01-18" version="1">MSGLRAHFAEDPVTPPVEKVGDDEQSPFQLPPDGARTPLDEKPVPFSRPSTPTPAHDQLAFVGLGEMGKRMATNLALYLSKEGQPPLIVYNRKEDGLAHFEEYAKEKELPDSAYVVKTELEEIGRTADLVITSLAGDEAVQEVYAKLFEGQETQRGTGDGIIPGGRGRTTIFVDTSTVYPTTAGVIENIANAKPHRAFLSCPVFGVPRAAETADLILAMAGDYFAKKHAAHALVPAIGKKVIDLGSNVERAMSFKLVGNSLELGFIELLSECFTLCDQTGVGSEKLVELIKLQHKSPALIRYADRITKNKFDSTGGFNLGGGINDARNIRQLAESHNVPMPCMDVAQQHMLSARAHGGDTMDWTALVGGQRISAGLEPFAGKVRLEKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAK6</accession>
    <name>A0A1E3IAK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028466.1">
        <property type="nucleotide sequence ID" value="XM_019179520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAK6"/>
    <dbReference type="GeneID" id="30196737"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1118" mass="117517" checksum="6FBB43C07099F537" modified="2017-01-18" version="1">MVLINEKKYACERCIKGHRVSSCTHTDRALFEIKKKGRPGTQCKHCKEKRKSVGSSVHTKCKCGSSNPLACEDTSAEGSTAPAAEPEVETRKGQPGSRPAFPRGLKDVHELSAAANALQGLGEDDAVVKSAERTVQALLNPCRCDYGGPCSCCEPKRRSRKQSPPSTGTGTLIASTAPSPIDTIIASYPTEAYSKLSPTSYLNPDNPQRASNKTRLYSPYTTDPRGRRDSPSNSVGSTSSPSGWNSPRSVRPPPTRVKPLTDIKRFLTAAMNKDGSLASEIPRSVLGLPGIQTFDAAAKGELVTGGGGACCGGGGGDDPSEDVDMALAFPTLEDVVLGACMCGEDCSCPGCATHDTTNTSNGETGHDGPCGEPCQGHHNCSSSIPIPSGVQSIAQLVVLAAAQVPKPPSRPVGSFIDPLDTRVLPPAAFSSDEAARKLGLVPLRPLECCGGKCQCPPGQCTCQKQCCGCCGECSCDKDEDTHMGGDQEAEVTEGQGACCGAGKGTTAELIPKEVPEPLAPTSSTKAAIANITYHPTMRHAMMQSAQIQASAQRSIDPYPPSPVTASAPRPAQSGCCSSKAQLPKPPALPKRASDSGILSHTASPRASSGLGRSGSLSSGNRRETGQRKIAPLPVAQTLEARPNKQRAMQPAQPKLYAGTAANPSTAAVPAIPANIEKENQALLEFIEKQWQSAPEDEFTLTSGLDGSGAIQKEGMAMPISFSAEPWAYPPQKEDDENQHGQATQLLEAGADQMDLDAFLRSIGAQYAGQSEVGTAPVAQAQIPSQARSDVPSIEQYGFGSPDFFFTPGQTYPQPPGNVTEESYPQSSQMQHHTMMPAIAPPKVSDGERPEAQSRATAPPYTYLWNTFMGQMPLETEGSGQGLEAAQMQQYKGKEKALSVGVSNGDGQGGRDMVDLSKPIDAAVYQRILQALEKQQLQPSLSTPNAPHHGGSRAQPPPQLARRPASRPSFSARPRSAPKPFYQSSASPQQTFPPAHSPSLNSPYATDAVAKELDDMFSQFVTLDGVVNTGQEGGSGHLEGLGGSAGLGMGMIGGGLDFVEDNEMGFSQPSRLPDWSGPGDSAGSTGPKESPENIRRGWEMMGFGGNGNIGWDKARVWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBQ8</accession>
    <name>A0A1E3IBQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028570.1">
        <property type="nucleotide sequence ID" value="XM_019179429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBQ8"/>
    <dbReference type="GeneID" id="30196640"/>
    <dbReference type="OrthoDB" id="10291857at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="337" mass="37730" checksum="D10BC582D8BC9FB3" modified="2017-01-18" version="1">MPATEITSFPPLLPVELRIHIFDYFLDILPLSHIAKLAPLSKCVYSRVTPLLYRDLVLNRSNCEAFFYGFKDGLKEGEREEWYKPNIDPSSSQSTVARTLKLFFLSTSVTIQDVDALFACFTALRLIFGSLKLPAPPEGSWGPSIGEWPVLFHNAGREEGRLTWGSDLIQSVQAGLKRDPRYRGMADWSLLPYLTAKKTESMTFVALPSEWSTSLVYFVTHVLASGRVKKVDFRECEPASVELDNTDIGKHTFVEEVEIYIPTKTSLSRSEVYEGCVHAVRNLAQSSQSLRTITFHNYPLDSADKGDGEADSLLGAAERGAENLLEMRLEDIGIILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDT0</accession>
    <name>A0A1E3IDT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028768.1">
        <property type="nucleotide sequence ID" value="XM_019179287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDT0"/>
    <dbReference type="GeneID" id="30196490"/>
    <dbReference type="OrthoDB" id="10338046at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="188" mass="21052" checksum="F4BC5434ED640A53" modified="2017-01-18" version="1">MTSVIMNNNNNCEEEFLPSYEPHGFDDSSSVYVDYVGYEDYEDESDDESEQTARNVPNGLILTCVQNGNWFLGSHFSAAHTHIYVCRNPSSISPAARSTVASLASILELAYQPSLHESPMWVAGKLEDDIKWLKGSIDKFRGFTHIRFKDRKAYYKAVQAVKAAAGTCRSPKDREVEMIFPGGVRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDX5</accession>
    <name>A0A1E3IDX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07155</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028785.1">
        <property type="nucleotide sequence ID" value="XM_019179168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDX5"/>
    <dbReference type="GeneID" id="30196366"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN86793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="39872" checksum="B2C1922801641F22" modified="2017-01-18" version="1">MAAPGPSPGLAQVRAFPRSRTGSRKNTPSLPADRLFSEKEAGQTIATTNPKTGQEGRSGKVLALGYAVIEVGEDEDSVPPLSVFYPPSSHPKPAQARPQCFARRVLLGWLSPRTNVYGRWCTGYCRRHSFGMDETTVNGELDLFTDDVHYIEPLPANVGTTTYAGVGPLLPLGSGTSTRSSEIPSVVVCTKADLMDNAAEDVKFNGGRWEEKTDRARQALGNVCLAYGAALFYTAPTQPTTYALLKSYTVPPPLISPPASPNTVSAPAIVGSTKFPFNHRANVLDRDAAMIPSGWDSWGKINVLRDGSDPAQLEKGWKVSLSRYGDPQPTRPPHERPQPRFQPIFRHAASATSSSNVPSGDGRSDWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IF69</accession>
    <name>A0A1E3IF69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028749.1">
        <property type="nucleotide sequence ID" value="XM_019179268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IF69"/>
    <dbReference type="GeneID" id="30196471"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="62" mass="6701" checksum="F51AB3A20374EDF7" modified="2017-01-18" version="1">MRPKAVTVVKEELVKAEMAKEGPWGRLQAPTPTIAVGTGTVLAGGHWGHQIMVRAHRGCDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM4</accession>
    <name>A0A1E3IGM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029085.1">
        <property type="nucleotide sequence ID" value="XM_019178991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM4"/>
    <dbReference type="GeneID" id="30196183"/>
    <dbReference type="OrthoDB" id="2577721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10738" checksum="2DDCBE62D4908135" modified="2017-01-18" version="1">MSRSSEKYLTPLWNSLAAAIRKAADLHLGDKVGQILLSQVETDDLTLIKHASQIPNRRRGSRFVREWPIESLLKQRLENSKKEARRKAQETTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IH56</accession>
    <name>A0A1E3IH56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029098.1">
        <property type="nucleotide sequence ID" value="XM_019179004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IH56"/>
    <dbReference type="GeneID" id="30196197"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003052">
        <property type="entry name" value="PRK03971.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN87755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="38777" checksum="F9197DE7FA458F20" modified="2017-01-18" version="1">MSNDAHNAVLMPSEALPENAVHIKGPDFNNAIDLEALLKGYETIGFQATGLSRAVQIIEEMRQRRKDPEQPLTLFLGYTSNLISSGLREILKFLAQNKLVDCFVTTAGGVEEDFIKCLGSTVLGDFHLDGASLRKRGLNRIGNLLVPNSNYCAFEDWVVPILDKMVEEQEQQGTQWSPSSIIHRLGKEIDNEESVYYWCYKNDIPVFCPALTDGSLGDMMYFHTYKTSPAQLSVDIVADIRKLNDMSVKAKQAGAIILGGGVCKHQIANAMLFRNGADYAVYINTGQEYDGSDSGARPDEAVSWGKIKAGAESVKVYADATLVFPLVVAATFGKAHWAEQAKKAEQAKEEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IH62</accession>
    <name>A0A1E3IH62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028855.1">
        <property type="nucleotide sequence ID" value="XM_019179097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IH62"/>
    <dbReference type="GeneID" id="30196294"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="298" mass="32458" checksum="92386CA9EEE7917B" modified="2017-01-18" version="1">MHSIQLHSSSCSHPFHSPHHVHARSTTSDVRLFPTTAQRRWDHHPPFPRLSLSISFSNHDHHLALSLARSWIFPEKCRNLPHPLTILSWVAPDSHHEPGDLFYFSGDIAHDGNASFALPMHSASEAHINTSSPTVPKYQRLLQESSGIFKQKKTEKILEKGEAQRCSASGGEVEVDVPKLNREAEVPEWERGIDSEGEGSVAKRMSFVKSVEGLCNRVGTGSVPRFGINPSGINSAPVLAIADTHDATCVIAACSVPCCLPLSGLRPKVPCVFKTASLRVGLGATPKQSGLKLENALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIK3</accession>
    <name>A0A1E3IIK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenoprotein W</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029246.1">
        <property type="nucleotide sequence ID" value="XM_019178763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIK3"/>
    <dbReference type="GeneID" id="30195920"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16726" checksum="6178FE48D22CD838" modified="2017-01-18" version="1">MLDTCTDCEKPPQPAPAPAPAPAPTPASSGNTAEEPFIAPDLNQVKPSVVIEFCDRCRWAPRATWIQTELFLTFPTPLLRTITLMPGNTPETGGRFRVWVDNGDGKGDQLAWDRKTEGGFPELKVLKQRIRNIIQPDLGLGHSDVHGKQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJW3</accession>
    <name>A0A1E3IJW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029366.1">
        <property type="nucleotide sequence ID" value="XM_019178665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJW3"/>
    <dbReference type="GeneID" id="30195822"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="41783" checksum="DF18D2AEA8BDE9EF" modified="2017-01-18" version="1">MSTRLENLDSDLKFGVASALLGLHPSHTFVQKFEELQKAGFRYCEVLTADYIGWVRQQKPELPESTCPPAWAEFSEPDPSDSEIWAALSTFAPKFTALANQYGLKVIVLQPLPHFEGWPEGHEREEWSRRKAERWLGLCAELGVEFLQVGANDRKDATADDEKTASDMRWLADLGAKQDPPVKIAYECWCFGDLRGDWEDHPNLGLCLDTAQLALSPTYGWDPLTGNGWSLPEYTSMLSRLRTLPKDKIFYLELSDVLQPSPPLYGGSKFDESAREDEKGYGKGKNARGKWVFYARHVPLVGPNGGTGEGDGEEERASEVGESDAARVVETLKSIFSTGWRGYCMFEAFESIYMGADDPGVPRRYAQAFESAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKN5</accession>
    <name>A0A1E3IKN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029444.1">
        <property type="nucleotide sequence ID" value="XM_019178537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKN5"/>
    <dbReference type="GeneID" id="30195692"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="279" mass="30094" checksum="4265016F5FA1F7DE" modified="2017-01-18" version="1">MSQVYFDISIANTPAGRITFRLYDDIVPRTTENFKQLCTGVNGFGYAGSGFHRVIPQFMLQGGDFTRGNGTGGKSIYGQKFGDENFIKRHDKPFLLSMANAGPNTNGSQFFITTVKTPWLDGKHVVFGEVTSGQDLVQQIEKLGSNSGSTPIFLSSGNSRSRVLGSGFHRVIPQFMLQGGDFTRGNGTGGKSIYGEKFADESFLMKHDKPFLLSMANAGPDTNGSQFFITTTVTSWLDGQHVVFGEVTHGQDLVKQIESLGGPSGRVAKPVVISASGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMB3</accession>
    <name>A0A1E3IMB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029652.1">
        <property type="nucleotide sequence ID" value="XM_019178496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMB3"/>
    <dbReference type="GeneID" id="30195649"/>
    <dbReference type="OrthoDB" id="2577069at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41935" checksum="4B1246C39B249690" modified="2017-01-18" version="1">MSLITLDPLPSDVRSLIFECLQKTTHKPTLASLARVSRSIYAQSIPRLYKRVRLNAFNVEAFFGCLISDGLGGIDKEISAHELHIDNYFGQLEANENYILAVSYIPSPIARKICQIWQTSHVLLEDGTSAAYLQEALTSFKYLRRQLWNRIDGLDDDDRDWRMDRFCHSLFFPGTFDAMILGESLCRCFTLYPEVWKGAYDMLTRDDDLGVFTSLCLHLPSSCTGSAATRYCSRMVSMDLESSEKESENGVCELCIHNANPLDHMVDMASENLHIFLRPESSQGMLSHEASLGAFMSWHLDLVESQGRRLPNMFFYNSMFTDVDRVCHKGVNVWERLKTMGPPNDRPFTVKMFGPDKKELCPVCMVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMF2</accession>
    <name>A0A1E3IMF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029607.1">
        <property type="nucleotide sequence ID" value="XM_019178451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMF2"/>
    <dbReference type="GeneID" id="30195601"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129840" evidence="2">
        <location>
            <begin position="20"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="369"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="476"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="665"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="771" mass="81580" checksum="ACFF4D88C35AC89A" modified="2017-01-18" version="1">MRFSTAFSIIAALAAPANAYFILSHPVLETTRLDPIVSPGVISGHVHSVVGGNNFDKTMTYNSTQQGTCTTATVSVDKSNYWTPQLYYYSPTDDTYEAITVSFVNTYYLPRYSSGETTVRAFPDGLRMTSGDPYRRTYNNDADSNAISYVCLDYDTSHSGDTAWDQRNSFFEHNCPNGMRAQVNFRSCWDGVNLDSDDHQSHMAWPSGGVDGGDCPSTHPVRLVSLFYEFIYNVQDFPYNGVGNTTWVWSFGDVTGYGFHGDFVNGWPAHVNGTNVLQEALDECNDNNGVGGELAACAPFVPYLDSASAEGCTPLNDLVNEDIGSGHTISRLPGDNPLWIGNSTTKPSWGDSSDSDIGFTDFKSTIPDGYTEVGCMAEGTSGRALTGASFSATNMTRGICVQWCEDQGYPLAGMEYGSECYCGVSIRNGASNTTLLADSECNYACADNDYENCGGSATLSLFNNPSLYQVYTYPTGWSSSGCMTEATNARALAKYSVTSDSMTPQVCIAACQAKGYTIAGIEYSSECYCANAFSTGSVAADDSSCSMSCSGDALQTCGGSRRLSTWTYSNSSSSFSSSSSSSTSSLSSTSSASTTKVSTSSTFASTSKTSTSTSASTTKASTSTSASKTKASTSSTTTKASTTTSKASTTSSSTSTSASATSTIASLYVGCYSDSSPRHLDGSSYTSSSAMTNEACISYCGNLGFAYSGTEYASECHCGNIVQASLLREESHCKSVCTGDATEVCGWGGNLSIYETGVSATKRSLSAKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INJ5</accession>
    <name>A0A1E3INJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029702.1">
        <property type="nucleotide sequence ID" value="XM_019178264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INJ5"/>
    <dbReference type="GeneID" id="30195410"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="519" mass="56873" checksum="F930CF6DBDAAAF13" modified="2017-01-18" version="1">MVRHASFQPDPVQAENEKSFSAHLDQKPEDEQMESPLHAVGTRTTEATDTEKGSTRYAESATGLTHKQESKKAIRKLLRKMDFGILPFAILLYLSAYLDRGNLANAKLQGLEADLLDSKDTNYSIALCCFFITYIVFSVPGTLLAKQFLPSRTIACGAMIWSVAATCQAAAQNKAGLYVCRLFVGVGEAMFGQAMALHLSFWYTKSDLAKRVGLFISAGAVSGAFGGLISYGRILFLIEGCPSVLLAICVFLFMPSKPEKSRYLNEDERTICLTRLNEEHNVESEQGINWGGVKRCLTDWKTYAISVSYSCMNLTLGSVSGFLPTIVKGFGYTDAKAQLMTVPPYVVSLVFMLFLTSFSDWKQSRGLPAASVFCIGIVGWAILLSMDADSNYSARYFAVICVVTAGYTNIPIIMSWQSGCTGNQSQRAASLGMLNTLGQCLSLAAAFLFPKVEGPQYTKGATVNLAMQSLGLVIVLCMTTYYRWENARRDKVEGGRPAKGTPINVRDDYDLAVGFRYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP52</accession>
    <name>A0A1E3IP52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029615.1">
        <property type="nucleotide sequence ID" value="XM_019178459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP52"/>
    <dbReference type="GeneID" id="30195611"/>
    <dbReference type="OrthoDB" id="2564290at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="427" mass="45830" checksum="621A7D16CAF96886" modified="2017-01-18" version="1">MSAFSDASVASPALPLTPSASRATSPLHIPHAQPEYDYATPTHSPLTPPPSLRLYSSALKAKMAAGMTAAMRDLRDDRSAFSGHKLDTDFAYDEDPIERHVRLYLTPRTSIHPQRPQRPSHVPAEGSSSPPYSAPPAVKAVPKQLHVTMDGAEGTPSYEIVTIDETPRVKQNGFRRPFADDSDADTDDEEPPEMLVRSPALFSPSTSASVDQFIPGLINFRTNSSTSTSSSHLLAPRPDAWRMDSGASTASDASFEAIKAEDMVSLYGGGVKREGSFEEDALSDEEEGVLGWPDRGSMVSTSTRDTVRPNKTPKLTPTSTIHPLSPNPSALHALLPSADLSTPPLLAPFLEPSSCRRPAHLSEGLTTASDDGYGARADESGSTGLGLEGVQPAWLKERTLSEKMVLDAGLRTQRQRAGVRRRVGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQB9</accession>
    <name>A0A1E3IQB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029830.1">
        <property type="nucleotide sequence ID" value="XM_019178111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQB9"/>
    <dbReference type="GeneID" id="30195256"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000086">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="25840" checksum="77D8F03FC4538E78" modified="2017-01-18" version="1">MSKEAALETFPLRDYNFVERESQPEEDHSVTARLKRLEAHYEESGVRRTVEAVMVVTVRGFPHVLVLQVANAFYKLPGGYLDPSESDSVGLITRLNEQLGVPIGTVAPHKGNDLPQNIWLAPEGGRDWEVRDCLSTWYRPHYDTFFYPYAPAHVSKPKECKKMYLVNLPPSKTFAVPANMKLHAIPIFEFYDNAARYGPQFAGIPYILSRFKLTGPEVDGVDEEVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQE6</accession>
    <name>A0A1E3IQE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029929.1">
        <property type="nucleotide sequence ID" value="XM_019178210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQE6"/>
    <dbReference type="GeneID" id="30195356"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129957" description="Solute carrier family 39 (Zinc transporter), member 1/2/3" evidence="6">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37968" checksum="884A7B1494251BA5" modified="2017-01-18" version="1">MSLLPWPLTLFIAFSTCFPPYTQAQEVTSSVNPAPLGSTCTPGEAGYYDLGLHIASVFVLLVASALGVFSPVVLGDRGNKNGWFGTTFFTLKYFGTGIIISLAFCHLLHEAIVAFFNPCIGELSYPPTAPSIVMASMFVIWLVDFFGSRWIAMKDAETARNTPRHADPLSQSETPVMADMACCSTKVQAVESFDGASRRAHWDVNLLEGGIVFHSIMIGVSLGAQTKGFKPTFAALVFHQLFEGLGLGSRIGMLIWPPGIASILKKYSLCLAYTLVTPGIGVHQSFNENGRSELLAIGILNSISAGILLYGGLCQLLYAEWVVGEMRGASGRKIGLALGALVAGMIAMGVIGKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQP5</accession>
    <name>A0A1E3IQP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029778.1">
        <property type="nucleotide sequence ID" value="XM_019178340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQP5"/>
    <dbReference type="GeneID" id="30195486"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="236" mass="25402" checksum="191562F74834853B" modified="2017-01-18" version="1">MGTRTTNDMGLVDSANASPDFRQPPPMSVPELDLDYVGGGEVGFANGEKGVRRWEEDGEEENTPIPNSSNKSDPEEPVTRASLARMYKSSPVEGSSVAETSSGRKSLSESTIDTTTSSLSPNPNLLAHDESTTEGAIAPDLRVEQESAGMELRRKKKEKRERKKAEKKELEAKQKEMSDAEQEGRVVQDDTKGESDASSSASSPPHPDASESPSSVPGRLHKVIAEAPRYTGDTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS32</accession>
    <name>A0A1E3IS32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030015.1">
        <property type="nucleotide sequence ID" value="XM_019177976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS32"/>
    <dbReference type="GeneID" id="30195115"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="75"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="255" mass="27072" checksum="E5EE46AF4527DBCF" modified="2017-01-18" version="1">MLIHLTYPAPLARITLNLPGTSSLADLPIPTALHNTYLRTASTGALPLATPLSDLAHKDAPNHPVTIHVTPRMIGGKGGFGSQLRAAGGRMSSGKNTNMDSCRDLSGRRLGTIKEAQRQAELLESEPALRAQAAAAEKAKLETLERKLGINAAESSSAGGKRRPEDVDLEELARKKHKFEDNKFLEESREINENVRSAVSAALLLKKKKKAKAAAAEKGKGKATEDKSKEVKKAVQDKIAMPPPAPAPASTATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITT6</accession>
    <name>A0A1E3ITT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030158.1">
        <property type="nucleotide sequence ID" value="XM_019177774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITT6"/>
    <dbReference type="GeneID" id="30194908"/>
    <dbReference type="OrthoDB" id="2573735at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="923" mass="101199" checksum="429EE7FCF39ED706" modified="2017-01-18" version="1">MTSFIRDLYGFFMDSDEALNHLPAILDQQAAEQSLGNVRFSNEWLQQRAKIDECLAEKSDESLTRALKIFAKVIDTLDLYAPALKGLTDVHAYACETLESIIFDQQKVDQRGQAAAFLYGQAMAMSSLTAEAVTLAIENLGNNTAANLALCIILGVERSSPTLFESHLPELLQQVQMAAFDSDATDFVQDKSVPQEALIRALKIYCPSEKVSSCRMILQATHTIFVASLHLCQKAHKAEEGVFWTCFLIEHMPMMLRNDLAHRYPQTMRSIPIFTLLLPLGPRLSPASQASLCSALPLLATWETSLFVDSEWFTMSIHFMLGTKKSLRAEGLKGLGQMASVVLDRFEPFLDEIGEMALGVLDREEKPAVQKAAQRLLACLLASQGPTTLDIMIHYLRSPHHILLADVELLEMIATLLPNLARRIIQTLTDIIDDLLTEKGGAEEGDVEGRGSRRASVLDALNVFPLRDRDLTAKAQKLVLWSLEEDSGQPVVVAALQLSTNPIIATPSVVRSLTFKVAQLLLADDPYIVHTALSVLSNPALASMLDKSSCSMILLALHQSMEPSIQIIAAKLLAHLTTAHKAIVQPLAWSHIRQSLSLIDFLHSVDPTKAIIEACIISNLLPALPPSLHKKYVGPVKELIMTGLHRPCEPPTLSLIFQGLSNLAHFESYTSAQQSQLAQELLEKTQEIPKECQHAALNAISSLLSVPKEGLDVYELLIKVHARFGGGRGKTLDNDLKALVSGIYGHLGTVERNPVISRDSKAAINRETLNYPSKVAHLSRIAEVRDRHGPLNQTSINTLLAEILSASLSTSLKATDDRSLVLETMSCLGILQPHSIPSLIPDLPGLIMSELRYALKSRDAARDANSASVSAGLLFLSSTVHTSGIWLEQYWQEMGELMVECISSGEALPVLRGLDVILGSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU64</accession>
    <name>A0A1E3IU64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030287.1">
        <property type="nucleotide sequence ID" value="XM_019177903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU64"/>
    <dbReference type="GeneID" id="30195038"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="30572" checksum="847A491D374A7D8A" modified="2017-01-18" version="1">MTSAALVPCIADTYKQDLFKGKVLFCTGGRSGICYAIVESMMSLGVSAAIVGRDAKGLDESAKNLQDSTGSKCIAAPADVRKPEQIKDAVKRTVDAYGKIDFVICGAAGNFLSPISGLSENAFRTVVEIDLLGTYHTLKATLPYLRESHGAYLHISATLHYRGVPFQAHVAAAKAGVDALSNVIAVEEGPWGVRSNIIAPGPILGTVGADKLSMKGKKFGKDIPLSRAGHVDDIANAAIYLFSPAAAWVSGSTLVVDGAENHIRSLKFPYPETLLEPEKFKDLVKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUU2</accession>
    <name>A0A1E3IUU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030107.1">
        <property type="nucleotide sequence ID" value="XM_019178068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUU2"/>
    <dbReference type="GeneID" id="30195213"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="50514" checksum="00348030F62DF503" modified="2017-01-18" version="1">MDAETNNQWRFAQCFGDKGEVEDITEGKYPGSLLSDIISTVEFDHTGDYLATGDKGGRVVLFERNEAKRGCEYKFYTEFQSHEPEFDYLKSLEIEEKINRIKWCKRQNSAHFLLIIDKTIKLWKVFDKQIRVVAENNHSEGYGQNTGPSQPPLRLPRLTTHDSITAAVPRKVYANAHAYHINSISVNSDGETYISADDLRINLWNLDISDQSFNIVDIKPVNMEELTEVITAAEFHPIHCNLFMYSSSKGTIKLADMRDSALCDSHAKLFEEEEDPASKSFFSEIISSISDVKFSQDGRYILSRDYLTLKIWDIAMDSKPVKTINIHDHLRQKLCDLYENDCIFDKFECTFSGDGTQALTGSYHNYFRIYDVNSDNDVVLQADKSAFKAKKIGGARGKVPGKKEGLQTEGIDFSKKILHASWHPRENTIAIAATNNLFLYSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYI9</accession>
    <name>A0A1E3IYI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030398.1">
        <property type="nucleotide sequence ID" value="XM_019177647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYI9"/>
    <dbReference type="GeneID" id="30194779"/>
    <dbReference type="OrthoDB" id="2596760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="664" mass="71429" checksum="B02379C45D826128" modified="2017-01-18" version="1">MLPTPLRARQRRHQQTVDAAKAYQHESPPAAGHYPHTSASDSQHQNQETSDEGGSRGDSFGVESMSEWGSYMSSVDQAQRDDALGGRLHAAGGRDVSPISTEGLVFHRSDDEDGDSNGQSSGQVEPPSPEETLHPLEPIDPVDPSPTSHPLPLPFHSHLRLADLPPPGTPPSPSIPGSEPGSPMSLASMPSYVASMSSLSRTSSVDSPIHDHDETQGGSFRAEGDGGDRGLVLPQLNLPSESLSLHLSLPRWLNSWSSDDDHNQPHNKRGPITLALVGEREEVERLLREVKERVEMVKLDNGVGVLQNGKIGIRIVSGVKLDEQVQKSIHQAYQTLNALLSPVPPPSTEMESELKRLIDGYASREDWIHGVIVLGEVDKTSLDKMIPTITLSAPSASPEISHETPHSKNHALPESTPKPTETGLSYFTLPAHEEQPESDEESVAPSDLEHSPSISDSILPKLSPKAEVLLSSFASPRNLAERSTASFLAWRRSPYLSTTTSSRASYPTSPSPSASSYYAGAMPTVARAQGGGEWEATLSRRVAQRRESGDAVVSKSGKEFLKVKGQRKRRRSIDKGTGRGDYYQALFPRVSPGNTGKKDNMSSIIRKALAEWKGRLFPGTSAGAGSGGKGGEGGKGSGRRIWKWGVVAGAVFVLGWGVWLGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D9</accession>
    <name>A0A1E3J1D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030923.1">
        <property type="nucleotide sequence ID" value="XM_019176891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D9"/>
    <dbReference type="GeneID" id="30193997"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="618"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="79149" checksum="345319FEED97A121" modified="2017-01-18" version="1">MKYGKEFQQLLNESDFPEEWKSSAIEYRQLKKVIKDVVAELTSMGLSPDVLHKLLITEDTEGKSLIASHTPMVSDGGGEEDVIEFEFESEEGSPVVLRSGSVDLPPPPHHQPVEVIVHPVTEQQNLDDDEQSVESLHPHHHRKFRLRLLSETSQTPKEDGASVRPLSVTDIISAQEHTSNLSLEDVHHRGRGSELSARVHGKRKVVKKAVSDGHGGVKAEYVLTGDPQHPIPQLRLHLDTSISPSRSHSHSPSPAPSSFESETEPEIETETETEDENGGEEAFDLAMKTPRAFNKVTNPTLPSSPHLSRIKGARSPIWAIASSGVSEGMSDFSIGEAAVEEIPNPLPDPPSPNFSAMFEPASASTTERKFIIPLASDLAFFSLLTTALTSLSLFHARQQTLFQQSVERLCAMISKSISPQGSSLEVLPTPLTPSGSNMSDTVPRLHASTSAKASKKDLYAWREIFSLWIESQIFESTAERDRGERTIEQAESRLQKFAAEVVKRGLGDRRTMKGKKVKEAWEEFLRLNMLLLDLKRFQTANIKAAQKILKKHDKRTALTASIGFQSFVRSTLTAHSQIDKDGHISTWTFYNTSLPHVLLSSLTSTLLPILPSLDDYVCLICTSIAFKPIRLGCGHLFCVRCLVKLQKAGKGECPLCRKDVVLLADKSSLDLTIMHFMKQWFPKEVKEKQKENDAEVVNERALETGLDTRCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1M8</accession>
    <name>A0A1E3J1M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031038.1">
        <property type="nucleotide sequence ID" value="XM_019177006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1M8"/>
    <dbReference type="GeneID" id="30194116"/>
    <dbReference type="OrthoDB" id="10310297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="710" mass="79961" checksum="EBFD9AF48ED09EC9" modified="2017-01-18" version="1">MSELSKVPQEEKQRSLNIMVDYASSAIQNRARALIDVQRRKRHIDETTAALSQLASIKSADGTPLADPETDYKVLTLDDAESLLLMAGIRKPGEGRGDERIPHYHNWDANTASQWSKRIHQLSDNMEARRSMYAMGNDQAGDIREATSGLEKILNEDSVVNNNHEQDFKFKEALGFGRWRHLADGLRSQLIMETVLPKIANQIHSYTSQAHSANPETLPSARSKKQKLWDQSISEAESSIAYMGSTGWQVDPDDKAQFEQAVERSHTILSKKSEKAVQKIEAAFLLDDHSGYYDNTTFNETRIGDLQEHLEHKLPEVAHQKFVLDDGWKKLTGLPVDYVQIEQEMDAEAEALQGSQQSVATLSGYGIPQDILFQPSALEFTEQKLQRLQNTFEYSPDINAYRPSAAQSHVKNILALKSDAVSQLNTFLKAKVDQVDSKDIPRSQLLDLYESKKRSLTGDRESRLKSARMTAALSRYTDIEKKWEKLTKSAAGRILQKVADARDGLEQISQETQDIQDQSRYWRAQSDFATINALINESFQPAFDSKASKKAWLNEIQKDRTHAKSSLEKSWRLPRAASEPSLATVEEGVQTLLIDESVESIEPYLSLGKEAEQETATARPWRSRFNWADEDEGDADTTFDEDFKEWLAAEAKRNGRETAAVASTPASELHEAEPATSNVSAPVVTTNRWMRSDGKSAAQYLYEMSRASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J327</accession>
    <name>A0A1E3J327_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031227.1">
        <property type="nucleotide sequence ID" value="XM_019176752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J327"/>
    <dbReference type="GeneID" id="30193848"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130102" evidence="4">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="40399" checksum="823A4E4FBCCD1E72" modified="2017-01-18" version="1">MPVTVLLTGLNGFVAVHTAVTFLSQGSKVIGTVRSEDKKAKAEGRYLIAGEDYTLKQILDTTRKVQPDLQKYFNRARESVPPEASYVIDSSKNGLRYRTLEETIRDSVAGFEKLCAYGGSVILVTGGGRGVGEMIAEGYVVNGAKVVYISSRDAAACEQTAKRLTNQGPGKCISLPADLAKYDECVRLAKELEKRERVLHILVNNSGVTWGESFHSYPDAAFTKLLTLNVQRVFTLTQQLHPLLEKAHEEDRFIARIINIGSINGVGNPGLETYAYSSSKAALHQLSKHLANRLAPHITVNAIAPGPFRSKMMKHTLDHFEKELAEGLPLKRIGAPEDIASTALWLSGPGGAWVTGTVVPVDGGSLVATSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J355</accession>
    <name>A0A1E3J355_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031257.1">
        <property type="nucleotide sequence ID" value="XM_019176782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J355"/>
    <dbReference type="GeneID" id="30193881"/>
    <dbReference type="OrthoDB" id="3174109at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="672" mass="76689" checksum="2926602065E04DAC" modified="2017-01-18" version="1">MASMIERLMGKGPQSSDSSPYRPRREPLPYEVPDPNGVAWLLRLPDELFEKVFENIDRATFVRCHRVCSQINDFLSGNASMKLQNLLQTASLHLNPNALKPNTSNPHLVPPSRAFLLDQLRERLTRFRTFEHKEPETVKFEEREGRLYEFLEGILMRSIPPPDANPWTRAIGREMGVYEFDKMREWEDVKDGDEQDDSSVVESDVVDVEEQEEYGQFRRVTKLDFDMLDFTFDPGQDLFVAAQFVIYKAGDNPYISSKPGFQDPGNVPTSMILLHLLTISTFQPHPKAKDPVIVWPGISLKTQAPSMGFQICDDGLYVMRNQSTGFGGRDMLCGWQWTTGRHAVTLTASNASTFESFVMLSPSSFAIPSVKTAIRQEADIVDTMPSHTDLLFTHHLHIYAFPPLSSATFKAGEPVPPPHTATHVTTIDMPEFVVDFDDQIPPPRMTIRADPPPRYTFPTYPLANPQPFVPDPESGVFIIEFYCQPYSEVPIHYVMFIMRKMLLQYLPAPTSPLLYQTFTRPAPVVPFSKIAPKCRLLGPHQKVPSWVCYVYQDRYVTKEEIPIGNKLLLYDFNPLRVRQALQDPNIAVQLQSGALEVMNQETVIEAHKDYEFSVLAEKTVTGKELPCLVTKHKPVFEGEDDEVDTIIIDQERIIVFDDAEEEEARYMRVMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3J2</accession>
    <name>A0A1E3J3J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">L198_04827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030965.1">
        <property type="nucleotide sequence ID" value="XM_019176933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3J2"/>
    <dbReference type="GeneID" id="30194040"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="181"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="402"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="402"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN94686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="64490" checksum="BA7C7BD3145343E9" modified="2017-01-18" version="1">MANAPHGGVLKDLLVRDAPLQSQLTEESRSLKDIFLTERQLCDLELIMNGGFSPLEGFMNEADYTSVRDTLRLAKVAGQRQGHLFSMPITLDVSQEDIERLSLQAGARVALRDPRDDSALAILTVSDIYKPNKALEAEQVCGADDIAHPAVAYLRNTVKEFYVGGAVQAIKAPTHFDYVPLRYTPTELRAHFHKLAWRKVVAFQTRNPMHRAHRELTVRAARQRRANVLIHPVVGLTKPGDVDHYTRVRAYQALMPSYPEGMAHLALLPLAMRMAGPREAVWHAIIRKNFGATHFIVGRDHAGPGKNSQGQDFYGPYDAQELVTQFKDELSIEMVPFQAMTYLPGSDEYQPVDEVPKGTPTADISGTELRKRLRTGASIPDWFSYNGVVKVLRDSYPPRPQQGFTILISGLHNSGKDTIARALQVTLQQQGSRSVSLLLGEELRSDLDPHISRAVTPEQKHINLQRIGFVASELSKAGAAVIAAPVAPYERSRQAIQKTVVGSGGGNFFLVHVATPLEWCEKVDRRGLYKRARAGEIKNLTGVDDVYEDPENADLVCDLRNDTVPEIVHSIIMLLEGQNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3K5</accession>
    <name>A0A1E3J3K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031225.1">
        <property type="nucleotide sequence ID" value="XM_019176750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3K5"/>
    <dbReference type="GeneID" id="30193846"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13419" checksum="FA2B6162305F3017" modified="2017-01-18" version="1">MPDDTAQTLRQLKIKTGVVKRLHKEESSYEKEVVDQKAVVAKLKADEVDGADIRAAERVLRDSEMMVPHTRRSLEEAFNALSDLVNALGEDESVSTTQEFRDAFSILQQVEVDWKSEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J3</accession>
    <name>A0A1E3J4J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031427.1">
        <property type="nucleotide sequence ID" value="XM_019176499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J3"/>
    <dbReference type="GeneID" id="30193593"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="266" mass="28590" checksum="ADE7EE189CDF28FB" modified="2017-01-18" version="1">MSDLYLDPSIRDWVLVPITLIMLLVGILRHYVTQLLNSAPKKQSAAAVREQRALGRSAILRGTSTLSPIPPAAYKALSVSLAAALSSDEYIKPEDVKKEGDAPANPLEGAGMESAMDGMKKQAVMMVPNMVLMQYINMFFSGFVLMRLPFPLTAGFKSLLSRDIAMADLDVRWVSALSWYFLNLFGLNGVFKLILGADNAAVDTRDLTSTASLSGAGAGPMAGPGGTPDMTKLFKAEVENLSLAEGSYKWVGEGIEDRVLAGWGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J594</accession>
    <name>A0A1E3J594_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031266.1">
        <property type="nucleotide sequence ID" value="XM_019176791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J594"/>
    <dbReference type="GeneID" id="30193890"/>
    <dbReference type="OrthoDB" id="10296869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25379" checksum="9742E16410AAF211" modified="2017-01-18" version="1">MISHQDDSSTQDSSLDQVIEVLSDDSQDVIYGPKSEYCYLSFAPDVTFSCYLNPSLKRLTALRASTVPPGSIRGSEAGNQIVSYFEGWRATHESLLDPRMRHLADDKSLPSRLATKEELMTFFREGATLCEVEGCCKSALEMSKGGFEKTVKGGVDWFMREMEEHGKEFNSVLDRFEDEERKDIKKVVAESLGEGWEDQIRAFRSATDEGERVYFPVELAERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6E0</accession>
    <name>A0A1E3J6E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04144</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031676.1">
        <property type="nucleotide sequence ID" value="XM_019176266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6E0"/>
    <dbReference type="GeneID" id="30193357"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="73"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="375"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN96430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="650" mass="71395" checksum="E58733C3778781F7" modified="2017-01-18" version="1">MPSDNFSSLTPSRPAPPPPGPSGVAGHHPKPAKGPQPSISSTSYSPSFSAMAPTVSQSTSSIAIGVPNTTFTSTVRSGPVNVKEDGLRAFMWSKRWLVLGNTDLRIYKNQSSLSPLLSIPLKDVQDIQRVDLKPFCVEIETNDRLLYLAMRSDDDVYNWMDDIYNRSPKLGVSLPMNFVHQVHVGFDPRSGGFTGLPPQWSKLLTSSAITKEEAARNPEAVLDVLQFYTQQQASQQPHELPTPSAYSGHPSVVPVVPSPDADDHNKTYGSERVQVRHQAVNSSLGTQPVTTTSSHTAYQSKHPTEQSKTVSTSTLQFRKTNQPSVGLTSDSEPKALAPNLTTPDRPEKRISTMSEAQIMVKLRSVVSQGDPGQLYAKIKKVGQGASGMVFVAKVLSNGSKVAIKQMDLSQQPRKELIVNEIIVMKESQHPNVVNFLDSFLVRGTELWVVMEFMEGGALTDVIENNKLTEDQIAAICLETCRGLQHLHSRAIIHRDIKSDNLLLNSLGQVKITDFGFCAKLTDQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMVENEPPYLDEEPLKALYLIATNGTPTLKTPEKLSQDLKHFLSVCLCVDVAFRATSNELLRHAFLTLACPARDLAPLLGFKETLSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6H3</accession>
    <name>A0A1E3J6H3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35, member E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031361.1">
        <property type="nucleotide sequence ID" value="XM_019176433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6H3"/>
    <dbReference type="GeneID" id="30193527"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="93"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="59551" checksum="01B3B9F382CDDA7B" modified="2017-01-18" version="1">MAFPPPSRHRAPFAHQSSSLDVPTAPLPPPHYRSAIAPAPSFPDPALLPTGACPLDSPPSRRFSLPYLTSNSKSLLAALPAVATPSTATIRFISLCFLWYACSAISNNTGKVILNRFKYPVTLTLVQFFFVALCCAICSHKTIGWAGRLRRPTKAIMRGTLPLAVFQVGGHIFGSMAISRVPVSTVHTIKALSPLFTVMAYSLLFGVSYSPSTYLSLLPLTLGVMLACSFDISFSNFLGLICALGSTLVFVSQNIFFKKIMPTSSSGASESGGASAKLDKINLLYFSSGMAFILMFPLWVYSDARSLFNLWSAPAVQKNETSVLVYFFFNGTVHFAQSIIAFALLSSTSPVTYSIASLVKRIAVICLAIIWFKQPVHSVQAMGIIMTGIGLWMYNSAKRDVDRGEKKMRHVEAVRGGMLPTTIGDQRILEEQDSESDFKGTHNSPRPVYNNSYNINLPSSTTTAMKSSFSQSPFPAAHTNAPYPSPPASTTSSPPSDPAMLHHSRNRQRRLSAEGEKFRLPPSVNVRSPGIEEGNEFERVNRGIAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6W0</accession>
    <name>A0A1E3J6W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031828.1">
        <property type="nucleotide sequence ID" value="XM_019176418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6W0"/>
    <dbReference type="GeneID" id="30193511"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="231" mass="24848" checksum="A5D11E528D325EB6" modified="2017-01-18" version="1">MAANGNSSSAIRRKLVIVGDGAAGKTSLLNVFAVGHFPESYEPTVFDNYVTEIELDGKPVQLALWDTAGQEEYERLRPLSYSKAHVILIAFSVDTPDSLENVTQKWIEEVRSICGKAIPVILVACKTDLREKAIADGTYTPQRFTDRQTGQKIADSINARAYIETSALLNQNVDDVFEAATRAAVLVRDQGHGGVGASYDRSGNGTGDGSGGKSKREKGEKESMCGCCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8T1</accession>
    <name>A0A1E3J8T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031880.1">
        <property type="nucleotide sequence ID" value="XM_019175967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8T1"/>
    <dbReference type="GeneID" id="30193054"/>
    <dbReference type="OrthoDB" id="2575566at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36474" checksum="CBA507D300D1DC34" modified="2017-01-18" version="1">MSTAPFSEDALNRYRIAHPDRDLKPLLRRLHRTPVPSTSGDDSSLEAHLLHLELLKWKSTIERITGSVANLDRQKEEYTRQAEGLRKKTEGMKEVLEREKKELERARMNRDHRARCDELASRIKSRGRGRDELDAEISTVQTSLEEQRASHGIYAQAAQARADTFTQILNLVEKCRGIKLPVDPTLAAVAVEKEDPPTIITSAPINVTSSAPSSSGPPSSGAAPKLSANAPIFHPPAKLSVPSHELPNRPSASPISSASNGRNSARPPSYSLPHRPSGMRTSSTPAGAGNGKRGGGLEDGEVGEEGELSERSNSGGGGKRAREGDGGGKRSSRRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9R8</accession>
    <name>A0A1E3J9R8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032017.1">
        <property type="nucleotide sequence ID" value="XM_019176104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9R8"/>
    <dbReference type="GeneID" id="30193192"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="124"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="39012" checksum="6BF51DA9B7F7ABD6" modified="2017-01-18" version="1">MRPSTSILPLLTRASGSGHAVRPLPLLRTLHSSAPPLAPKNKGKFITDRPVKVDRTPTFPAPANPFAPAHKGTQYPPVVLRVLRHVNLLLGYNGRKRTTARETGRMMAGIVEAVKRDKPFWYDECDLPKTFHTFFSIHVVYIVITLIRLRALSNDIPNPLSPIPQPRLPGQPGTTPPPKSPSLLDRYQAATTGNYEYKYREVLLTHFFNIVENEIRLMLGAEITRDSAIKTRMQEYANWWRESQLTIDYIVGLTVSESADERAIADAELASWAWRFIFGRRGEGANGEGELVYPEGEAMKEGKELEMAEQIETIVKFIRRELARLDKISDRDVIAGNVGFFGPIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBN1</accession>
    <name>A0A1E3JBN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transcription elongation factor S-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03884</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031923.1">
        <property type="nucleotide sequence ID" value="XM_019176010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBN1"/>
    <dbReference type="GeneID" id="30193097"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000007">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="16">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN97321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="36541" checksum="9B9CD8D3A21C4410" modified="2017-01-18" version="1">MDAAAVTNKVRDLNAANHAGKPDDVLVILNTLKSQVVPTEDLLRSSKAGVAVGKLRQHPTPAVSSLAKEIVKKWRDAVEEKKKRKRAEGDDGKDVKKEKEDGGAKRVKAEAGSSAASHSRSTPASTSTPDIKQTSPPARQPLSTIDSSRTTPRTAKSDGIAASLKADASYDGGRADDVRDKCVILIYDALALDSNAESKILQERARGIERAAHKAMNNSTGNDYRAKMRSLYLNLKDKGNPALRNEIVLGDVTPETVASMTKDEMASESVRMLNQKLATDNLFKAKAVGETQAETDAFKCGRCQQRKCTYYQMQTRSADEPMTVSVFFTQKVMADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBQ7</accession>
    <name>A0A1E3JBQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ChAPs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032146.1">
        <property type="nucleotide sequence ID" value="XM_019175656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192740"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="2">
        <location>
            <begin position="771"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1326" mass="147602" checksum="2F86B80FAF15FCD4" modified="2017-01-18" version="1">MSELFKDIPEFVEADIGECLAARTETLGSFRELGPPDLCHVIKVSGKPPTQRDLGSYHYCSGVEASSSASLAAYLNSLQFSIEDSQAWFGKGSAWKVRSGTYCCFNAFSRVDMRVEANIPGGVEAFVVDLHGNRHAPSPELWQETYLSALLRAIRYADDASYRLAGYRKLDPITTPEAEERFLKAAEALFFRGWQLGSDPEIQVATVVTNHLTSAIIKYFSESFRLDRAANLFERMVVKEPEVAALVAKSYIGMNEEIKAVKIMNLALQSNPQSYPILHVQVDFLLSKRSLEWAQKVAQQAVNSAPSEFVTWAKLAETYIELGQFDQALLTLNSCPMFTYNERDLHRMPGPAKTHLPVKNFIAESNLLGEDSPRENEADVALFRLPAPNLRGTFAKAYSLLTLLVSKIGWDELLRTRSSVFVMEEEYRMHKTGPSVDAVDGGVAEGDLNSSTRGVKGTSSVASESETATPTEIPTIRISTESSRTPNVSHARTPSQLSPTKEEESEDANSDDAAEMDEPSLEKPETAQANEESHAPLGLKGEGEAPASSPFSNKRLCERWLDNLFIVLYEDLRVYTIWRAEISHFKTQHMSYRKTGTEWEILGELAWRLHHKEEAKDAYQRCLDSKFSAKALMKLLEVYANEGDLVKSLTAAVRLTTYHHRWYMDAAYPSLVAHYLYKLGLTHGHAKIQYSLLSMNLPVGIFEIMQPYMKYATVFNVAIETPGAGPSRLPLSVEPELEEAYEEELDLDESQEEADREAFLKKKNDYIELQHSSSDELLSSLASYLSTFQTDLSAVSGQISELQGKSTEIEGRLNGRKAVIPALNSLLADISLPPALVLTLRDTVPAQNPDLWLSAITQLDEKLVTLRMRSAKVQAASELQPVVDGLRIKALNVLPPFLLSLIKPLKSASKGLSTNLAVLQTSLLLKYQPFYAFLYRHSPRIAKQVERGYVNAARSYYETAFRRYARSLTQIRTRSPEKNERIGVVGGEALLSGEKEGLSEAYERLGYAEVGEGGVVLSFMADDKDYKLPVEALFRSLSLVLLDNASAEFTFIVRFFSLPALQSQPPSSDRLNTLSPLSTPLESSSASFVDITSEAGGRGTPKKRPNGHTPDNNSEGLKEAERIWHEVFDSALESTSQFYHSILSPPPPAIPLLTIIRLNDRLLNIASLRGTIPLDSYFTAQKLSLWPVFRKEMDQHVDSLKRMADDAEGKGFAGLVKAGVKNGAVRKVAGRYAGMFGCVLGLSEESDEAMFVSMTRLRTELVRLIQNQSLKIKSLPERHSFVSSIYEIVMHELVSGPGPTTHPRLQSELSFFRTREEEARRKIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBV1</accession>
    <name>A0A1E3JBV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032191.1">
        <property type="nucleotide sequence ID" value="XM_019175701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBV1"/>
    <dbReference type="GeneID" id="30192786"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="40005" checksum="88418E4C2F94CCE4" modified="2017-01-18" version="1">MTVQPSEKGPIPVTCFTGFLGAGKTTTILSLLQQLPKDYKVVLLKNEYGDVEVDSILASQSNITGVSEILNGCLCCTSVGLISNALLEVQSTLKPDRIIIESSGSAFPATLALQIKELEPQGFKLDGVVTVVDCVNFGGYEDSSPSAQLQAKYTDLLLLNKHQIPNEREYDVLLDRLNDLNDETPKIKIGPAPSNPPKPEIIFGLDSKLWDATGKERKDWGVIGEEGKWHGDEVEVKGVYKGKRPVKHDHAHGEACGTCEKGEQEVETVGEVEPLEREALEKELAKLSFEIYRVKGLVRLTSPTKPYETHILNYAFSNFTVTPVPSLDEDEDLKGVSLRLTVMGERGEVARRARRFAEALGAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC32</accession>
    <name>A0A1E3JC32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032073.1">
        <property type="nucleotide sequence ID" value="XM_019176160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC32"/>
    <dbReference type="GeneID" id="30193251"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="271"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="785"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="927" mass="103977" checksum="A02E8BFBADE85B0E" modified="2017-01-18" version="1">MPIPVMAQTAPPPQGGKLTKAAFFRARSPPIVSPTSATSANSRASRNDPQEPLDDSMYARFNMPSNGTSAQSRSIQGAIGYGEERDRFDGGYSGGSGLGAPQRESIYNTPATAGHGPTLDRRISHPNNPRYDPQAQAPSSYQAPSIGGATSQSSHYPTERTHQPYSHTRQSSRSKSLHSRTGSTSSRRQLPLVTPALSQVPDPSVLSPRDSDSGYGESMETSESQPRGDYHLRGGYGTNMRDNEGELGRSRSARENGNTSLTEGSDEMLLSLLAGQAVMDCQQMGIAGWEDVEGWKKELSLLSSRVDSVQARHQREIKILTAARALQKLNNSNKRMSRQTLESLEQSEKKVAAVEKDLLTLRDREASVRRQVLEHFGGVMSWEVKRLERINAEVMSRFEGMQARMDGVEEKEAELVRDVQEGRMKVEELEAIVSELQRREQAFDDETRQLEDQIARAQQDQSNWQRERSQIDQERQAWMEEKEIWDRQAANFDAERRRWAEEKEALFGDREKMMQQSGQSSERDRKIKSHVQTTLGALLGRRAGQVDEEEIVPAFEQLRTVLSEREREIMSLREEVREVNMGLEQEVRRVGEDRDAWKAKVEKGEAMKQEEVASLERSLRQQQDQITNLTLRNESLSSSLAAAQSTLSVVPSPSTAQGNEQRNQALSAELEEIAKQFASIWPLLPSRAEREKADLIDPRTGQSNKALASPSNSIRFEALQALYAPGRPTSTSLTSIPEALSRIKGMVEDGELLVDRVVRMGKERETLKTNAAKAKKLVEGSTRSLQTYQQQVTILEDRLAKSSQSESHFLDELNSLQSLVDTNQQAKRTLEQKLAQQMETCNRLSEANDTLSARALELAQVAEDEKRALQQKLQGELEETKRKLNRVEEDADEDRAKSTGQNIQLLDELNSLQAEVGSLRTQLRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEC9</accession>
    <name>A0A1E3JEC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp60-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032318.1">
        <property type="nucleotide sequence ID" value="XM_019175828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEC9"/>
    <dbReference type="GeneID" id="30192914"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="584" mass="61465" checksum="6E6BA4DC26CFBE5B" modified="2017-01-18" version="1">MNPLRSRAALPRPARLAQNLAPRISKRSFASKDVVFGNDARQGMLRGVDTLAKAVSATLGPKGRTVIIGQSFGGPKITKDGVSVAKAITLKDPVENLGARLVQDVASKTNDTAGDGTTTATVLARAIYAEGVKNVAAGCNPMDLRRGAQKAVDKVLEVLASNKKVITTSEEIAQVATISANGDTHVGSIIAQAMEKVGKEGVITVKEGRTIDDEIEITEGMRFDRGFISPYLITDAKNQRVELEKPFILLSEKKISALQDILPSLEIAASTRRPLLIIAEDIDGEALAAIILNKLRGQLSVAAVKAPGFGDNRKSILGDIAILTGGTVFSEELDVKLEKATPDLFGSTGSVTITKEDTIVLNGDGDKNLIQARCEQLRGLINDATTSDYDRTKLQERLAKLGGGVAVIKVGGSSEVEVGEKKDRYDDALNATRAAVEEGIVPGGGTALLKASATLEDIAVDNFDQKLGVAMIRQAIRRPVRTIVENAGEEGSVVVGKLLSEEFVSADKFNWGYDAQTSQYRDMIAAGILDPLKVVRTALIDASGVASLLTTSEACVVDAEEKAPPAGMGGMGGMGGMGGMPGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEP2</accession>
    <name>A0A1E3JEP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032427.1">
        <property type="nucleotide sequence ID" value="XM_019175324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEP2"/>
    <dbReference type="GeneID" id="30192405"/>
    <dbReference type="OrthoDB" id="2592022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="947" mass="104325" checksum="E0BD06BFCAE24505" modified="2017-01-18" version="1">MLEITSLRSQLAQYQFIAHTSSIQLQGSRLETSLTNDKLEKTHRVHESLLKELEILRANPPLPPVQSGSQALTELSLAHRRLSSKLDLTESRLLSTSSDLASAKHALQRLVLEREEERRVLSEVKRVEWEKEEEVEWEKGERGKAEGQLKLLELALEEYKKLVHKLDPNAVPPDVPAKPTSSWLTSSVQADDAGIDKEAHPSTKGEETEDNIESSKEAISNLLIGQRGVAQLFHDFTISLTSKDALISSLQSQIDALNTSLATVEGQLKEETARRVEVEEEKEKVDRDDKSAAGVVERYMTFTQKTHKTVYMHLDNQRTRSQATITALRAQVGVLKTQLAAEAARAQGLRAALDELSFSSTRESAGRRREIALRLRMIAEEEKRAKKVEVWSEKVKRLREGVEGAVLEADVLEGLLDEGLEAASGYLPSLEAGGIDEGKRKSWRGILPRLRKRSSTHFQNGDRDPAEESLARVLLAEDLVTTLAQDLQIEQERRMELERQRVEWLAKDAVEGVKVDGELEYGGEESKVWFDMEGEGDEKDQSPKALQVEVPPPETIEEPASPISEPSSEPSSPSPSPEISTLHTLFDPIQTRYSPLQRNLHDLSLSLFSLRGSITSDPPPTPSSPIMPTSGKKASFLPLARLPLPSPGVPGFGGKMSAQTTIETLSDALHEVIEDARVDVEIALADIERVYRGFEALLDVSPLAPNPKVRSEADRVAVLGEAEEYVKHEEEGDEWKRLERKVGEVEADLAGLKRVLHSLEGMALESQRDDEEENVWQGVQFKTISLQPRHPSPLPTPLVSPLPEDQSSPFPFLSPSSSTTSLAFPTSARPPHIRQASLTGIGARGGGTEEEGRRRTSSMNPMHIGMGRGMLASVGNVGRSFSAGVVGGGKRVGGLASGLYKGAGDKPDVVVTEDPAKEEAEEAEEEEESSEEESESEELVRMTDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEQ1</accession>
    <name>A0A1E3JEQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03202</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032437.1">
        <property type="nucleotide sequence ID" value="XM_019175334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEQ1"/>
    <dbReference type="GeneID" id="30192415"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="66" mass="7341" checksum="3F377078B6444080" modified="2017-01-18" version="1">MGKVHGSLARAGKVRSQCPKVEPQEKKKQPKGRALKRLQYTRRFVNVTVAPGGKRRMNQQPVGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEW6</accession>
    <name>A0A1E3JEW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotide kinase 3'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032505.1">
        <property type="nucleotide sequence ID" value="XM_019175402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEW6"/>
    <dbReference type="GeneID" id="30192483"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="49214" checksum="D2BE3C4CB35C882A" modified="2017-01-18" version="1">MPPQKRESDGPEPPAKKAHPFFSGGARKQTLGTFLPSEPSLIHFTHLDPFSVVQHGSSSTQSGPKKAGVMFYDLDGTLIKPKSGAKFPKDREDWQWWHPSVPERLKKEYEEGKHLVVISNQGDKSPKRRGEWREKLSLIAAKMPKDIPFRVLAALDKDVYRKPNIGMFQSASELYRREGLVIDMDNSLFIGDAAGRPSNGGKPKDHNDTDYKFALNVGLKFVTPEEHFLGHPRPRFPEPAIGFRPSSLGNLESLPYIVPSHTPITREKIEIVLFVGYPASGKSSFYRKHFEPKGYAHVNQDTLRTKDKCLLVAEQELSNGKSVVVGDAVLTPPVDNTNRDSATRAHWTALAAKMQAPIRVFHFLCPPELAKHNNLYRAYYGPSNEPTRTALPPVAFGSFASNYEKPTKQEGFVEVRTVNLHFEGTEEQRKLWDMYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEZ9</accession>
    <name>A0A1E3JEZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032535.1">
        <property type="nucleotide sequence ID" value="XM_019175432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192515"/>
    <dbReference type="OrthoDB" id="2575080at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1316" mass="143891" checksum="9C4A5FD88022C2FB" modified="2017-01-18" version="1">MPAEQRSSFLDRSPTSPGTRFFRDLPAIAEKAGLKPAIVSSSSTQRSTTSRPSQKHAKPLRRFVTATAQGVPFVDLTLSDDDDDTPVFTKPAATQSGVIDFTNTSDSEDDEDIKPIPIMPPKSEAQRRREMEEDKRKGLNQSRLSFGGGPGAGSRPLSYSSSQRSSGSLAPTLGSSPSPATREPLTNKTSTPKVTAPPVMTKGKAKERAEPPALSSQTAPPGSTSQLKKYPAPSRESKPQPTVRSSASRSIQSLPRSQSSFSLPANDATPSPEHTPAELHGGEPKSFEPAFAAAAKKSSGIFKTANDTKAYAKSSRAVSRADLPTSTAPESRNALPTPATPHVSRQNASPEASSASRRRASEALDEVESVRHTRASSRQKSTEPTQVASRPTRARPVPGAYEIPSLDAAIWPTVPRSTHVTTRRKRKVEGVKREVDVVAEAVDEKRAEESRDRDRGISCVHSLGEELSSSPEPEKQSPAPLSAVPGPRTPTKRDARKTTSRSTTPQSSRAAVLFSSRSSQSAPTKQRSPLKSPSKLSNSITLGGSSSKEVEQMIPPSSPLTELTELSDEEEEEETKTPTKSSALSVQSATPRASIPKAESVKEVEVEQEPIEVEVDLDDIDLTEWDNFAWSAKPEAPTTPVKSDPGFSTPLKRASSVAQVTPRRSSSKRASAGLVVPDSVKKRKVEQEKWDRIVEETRVAKEAEEMEQRKKEEESARKIEEIVAEQPDQDEEEEDMGALLASGLEQSPQKASSSNLPDAVQSRQEAANARKEEQRLKKEVRDAEKKAAAKRKQEAKERDQQQRRFDRTLQGIKTGREEEAVWDEIDNSDDSEDDLSDVGTDEELDLSDADDPMEDDEREFDLDNVAAQLKSKGLAVDDNLLRDAKKGAFQAEAPLNWDGFWETSFKTTSGGIEIPEMDIASSDEFIREIKECCSQRDISALATIVSSGGLNLINKEHDLSVCKWLFMCALSAVDARWASTAATTLIQWISTRSPSLADSLVPWTSLILSQLGARKSILACQGLHDLSSPMVISKERDQVCIQLLRFLTCVLTKQLGKTTFSRLLLPSLLLLGIDTSSSDALKSHVVDAVRTLLLIHTIAQRLDDEPRMIAAQIVKSTESYGPDVRCAVLQFLGETTAESRDVYTWLGAEYLFESLGAGRHQTNKPSVPPITKVIPVVDQYSDSLRPAPTVEIDWVVKNFEMTFMFATINNPAKILDAVPPKLTSDESGRDLMQKHIMADFRHSLKASMNSIPDQSDGSKRPTVKARLHELVETIDLLFEEETSRRIRARKLGPGLKFGKNGQSRLNMSKGKGKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHF6</accession>
    <name>A0A1E3JHF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03203</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032438.1">
        <property type="nucleotide sequence ID" value="XM_019175335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHF6"/>
    <dbReference type="GeneID" id="30192416"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="469"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="839"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="849"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN99361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="983" mass="108826" checksum="3139803D16E0C1CF" modified="2017-01-18" version="1">MTTRPRTSYMVHSGFNDLINLISATPHRLGATPKGVNDGEPKRNLRFSPNRDSGLPRKSYEPPVAGGGYTDEELSKPPVPPKKGDRKESPKGLQSPRSPQSSKPPTPPAKEPPQSKELKKRKVDKREIGYPTDFRHIFHSSTYEEATELLLRWSAEGLSDKIGDPAWANPIKEVVKTRALEQQARAVAAVVEATARTRELGSAAHDLAPPGTLRVINGLPSSIYSSLNSNPLLNNPTPSSLDTAHVKPEPTTTTISPSLARASTPRMIANMAGYFEYESSRSSPGSALGQPGTSPESPMKFTNKKSLPLNMAPTLEPMVEHPDASDLPPGLLLPPSSSKKRDQRPSAQDLFTPLPFRVIKPTLPTLEKAMSVALFFEGYYHPFLSSEDSLNPYDLSSPGCHDKLLSSPIHPSNYPLLRARRQAALENTLLSPANRFMSPAQQDLVRAELQAEERRWLRERRRKVDVRAFEMGRVIGHGAFGVVRIAREREGGRLVAMKQLRKADMLQKSQEGHVKAEKDLLASASSSNPPPLPNLPASSAPAPSRIVQLFYAFQDTDHLYLVLEYMGGGDLLNLLVERDTFSEEMTRVYVAEMVLALEETHGLGYVHRDIKPDNFLFDKEGHIKISDFGLATDLHWAHDTSYYEQQRLALLKKHGVDLEYPSVHTKRMDRKDVKRILGKEWVEKGEGVLEWRERNRRKLAYSVCGTNSYMAPEVIRGQGYGFSCDWWSLGVIMYECLLNWPQTLKFPPAPKFSPACLDLITQLLCEPEDRLGSSSSSSSPMPLSGASSPHSGDGARATAGRPRGKRVLSAGSGLGLSKEEKGGLGKDGVEEIKRHAWFRGIDWDNLHRKKPPYSPDLYTDDDTRHFDDDIPGEPLAPPGSAQDSKDPLLRNKTHGAHLLEIRKQLAFKGWTFKSPHLDAPSGPTKETRYGHLDWVARGGGGGVEHLQDASDETVMAKDHAYAFVGEDDDGELRGTVKARAMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI29</accession>
    <name>A0A1E3JI29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032741.1">
        <property type="nucleotide sequence ID" value="XM_019175009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI29"/>
    <dbReference type="GeneID" id="30192081"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39954" checksum="37EF14DAD37AEEAA" modified="2017-01-18" version="1">MSSNIPTFDVASILSSLPDDILHLVFDAYASSLPTQSSAFLDLLCLDLLCLDRRTYNKYLPVLYRTIELTEDNRESFFQSYSRLLERCTFAPFEVESSDTSFFVPRLGPSAMGPPQPHPDMVRKIIVAHHLVFEMLEILHSTLQYTVAEQVKGLQSEEISVRLFPHLEWLTIGAEVSQAPPRSIVQRHRVVFRVLTQLLPPNICCTEPDDQAVWLFHQLGQAISSKYVHLDSMSIHASRWSECFKAGLSMERCEILSCWPTWPTGVRVHKDDPIVIVKALAILDRLDNLQIRRSSFPRQRIRLYDCNYTHEELFSPTSKTRLTLDQMSKVEIYTPKESAGHVCEGCGKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIP5</accession>
    <name>A0A1E3JIP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">White collar 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032946.1">
        <property type="nucleotide sequence ID" value="XM_019175214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIP5"/>
    <dbReference type="GeneID" id="30192294"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="42119" checksum="A226171A59C99997" modified="2017-01-18" version="1">MSLLAASLAGAKYQVSTNEERESSTNGAAEFQRRKKWPEVLLKELVGCAVFCIKPSLSPDSQQFQNGEAWSWRTVYASPSVTEMLGKRPNELEGKDFLDLVLSHDRPQLESFFNTLLAPPLLNINPQTISPLTSTYLGESHTTYIRMSSRAPPISRSNSGTNSGYNSGSSYYGTPSGSGRVEPVVWEIKGHATGIGEDLTEGSGGGDTLRMGADGTVIPGAGAESSGKHKAIWLMGRRVGEGATDEQQSHDAFMEVKLENERLQAELRDLQIEYGVDPSERLYRGGDAGSDASSPRSDTTEPVTDVKRKGKAGRPPKSGIKPSALGSAKKQKAAGRDGVKDGETMYVCVTCGRTDSPEWRKGPLGPKTLCNACGLRWAKRNGANNKKPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKQ3</accession>
    <name>A0A1E3JKQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division control protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032889.1">
        <property type="nucleotide sequence ID" value="XM_019175157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKQ3"/>
    <dbReference type="GeneID" id="30192236"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="686" mass="77093" checksum="F3A82A83F351CDB7" modified="2017-01-18" version="1">MPVLRPPSNDLRPSDFSYTHGYNSIVSRVRRNPGSATSGVVIFAGVDVEGLLGSRILCSLLKNDDVPYRLIPVGGTEELTDKVVDALASDEIHTLLMISLGSLLTVTEYFDIPRHVHLHVIDSHRPWNLGNLYNIDEDEDEEDAHGKVWIWGDGGEFSDPMNLLKKSFDALIFTPDSDSDDSESEDEDKEEDTEEDDDDEDEEGIGRKRKNAEDGPSRKRQREDDRPRKLPRAAKEAHQNRIANYYSHGTYYGQSVAVSIYLLATVLERADNDILWYAILAVTHQYITARIDRDRYEMYHSIFLDEVVRLNHEPDPGATKTPNPDNKNITRSEELRFMLFRHWDLYNSMLHSGYVAGRLGIWKEKGRSKLKGLLAKMGYSIQQCNQTWTHMDMELKRQLPEVLESVGPEYGLVELSYPSFTRAYGFSLSSLSAADAVEVISSLLDVAVGVRLEVDRAGGKGGGEWFGGTTRWSVGTREAEVAGVRNDDDDKNEEDGEEGEAKDRDWHVTNFWIAYDACDDIGLIRRSLPLAMALHQAIIRAGSGILEKTEVRHLHNLRLVILKEGPDLRIFSHPSPLSRLALWLVDATRDRWVEKLAKRSAHGGARVKDLPFVVACLNEEKGTFTVVGVTGAPEYGDVRKNKFGLAFQEAAQESNASTSLDLFDTSAVEVSKNDLKAFIEHLHVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLV4</accession>
    <name>A0A1E3JLV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033111.1">
        <property type="nucleotide sequence ID" value="XM_019174732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLV4"/>
    <dbReference type="GeneID" id="30191799"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="49205" checksum="C38082AA37996DFF" modified="2017-01-18" version="1">MAPTTPKGKGKAPVAVHDESKSIRAQSKKDKPKQDSADKSALSKDVQKAVLANPLTVPWPNMPKYLQDNVLHLLNELVPSHVADYHVLRARCQQSDKRRRRAQEHKAKNPPKDEDATMSEPESEPAETGQKRKRPTASAKTATTSGPPEKPEILSHLVMGINEVIKGLETQIDNLKLQLLVMGDTLNGNQPGKPGKPDLLPTAPRSPSPSSEGDVEDLSDPAPATKEKSPPITFIIVPLLSINPQSLVSPIPSYCATYNALAYQHAQLSKILQTRLKKEKWAEVMGEEREEVRVVPLGAVEKEMAEIVGLRRLACLGIRESHPDVSRLQELLPKAKLPPPRHSVTLPFPTSSLTVHTGRQSSSNSPNSAISNPQNLPPVTYAALHIKGIQTKQPADGNSRKAKRLQEVRGKREEAKVRKVEAKKAGKGKGSKGEKNGKGKKWTAAQVEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMA4</accession>
    <name>A0A1E3JMA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033247.1">
        <property type="nucleotide sequence ID" value="XM_019174868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMA4"/>
    <dbReference type="GeneID" id="30191939"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000077">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="245" mass="26443" checksum="330B733A80FAFD45" modified="2017-01-18" version="1">MTMQPPDFPDKVVIGVLALQGAFIEHIHYLQRLRPAGHTLEAIPVRTADELSRCHALVIPGGESTVISHLASLTPNLLPSLLAFAQDPAKAVWGTCAGMILMSEEDGVGGGKKKGVKGWAGFKGLKVWRNLYGTQLESFEAPLPIPALSSPAKPFNAIFIRAPAIHSLTPPPALDATTEVLAALPDEYLPSPPPSDSPLGEPRIEDLGKVMVRQGKKMITSFHPELSGDVRVHEYWVEKCVLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMB1</accession>
    <name>A0A1E3JMB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033250.1">
        <property type="nucleotide sequence ID" value="XM_019174871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMB1"/>
    <dbReference type="GeneID" id="30191942"/>
    <dbReference type="OrthoDB" id="10384626at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="28725" checksum="9C672E0D168DE7CD" modified="2017-01-18" version="1">MESATSTASVRASASTSLASSHTSSSTEFSSLVSSTGSLTSTATTSDASSTASSTDTSLLSPSSLSSLAKLLPTYLAIGGSILGLVIVVCLVSWLFNKKRRQSRFKSRFGDDEDEELEKNWKERRLMWGEVKKGERIWDPETGMGIVVDDEDLEATRRKKHRITLDDARITGEEGHEPQGSVYEAYPPSPPVTSRPTMRLLSTSSSPSSEIDISEARGHFPTSIEVQSIHSYVYNTPEPSPSASPVLGPVTDREEEEGLIKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JME7</accession>
    <name>A0A1E3JME7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">L198_02780</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033301.1">
        <property type="nucleotide sequence ID" value="XM_019174922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JME7"/>
    <dbReference type="GeneID" id="30191993"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23 33" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="31">
        <location>
            <begin position="603"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="32">
        <location>
            <begin position="764"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="ODO02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="901" mass="95400" checksum="704D6E63972CDCAC" modified="2017-01-18" version="1">MATPSTPGESSLATSIYSAKSPADQPQHNWHFSTLCANVDSKDQYGASSTPIYQTATFKGMDGSYDYTRSGNPTRSALENHLARLYGATQAFALSTGMTCLDTILRLVKPGETVIAGDDIYGGTNRLLTYLGTHGGVDVRHVDTTKVQKLLPHLGAGNKVKMVLLESPTNPLLRIADLREIADAVHAASPGALVVVDNTMMSPYLQRPLELGADIVYDSGTKYLSGHHDLMAGIVAASRTDVCKDIAFLINSVGSGLAPFDSFLLLRGVKTMSLRMDRQMATAQLVALYLDSFGFEVNYPGLKSHPMRDVHYKQATGAGAVLSFKTGDKELSERIVGGTRIWGISVSFGAVNSLISMPCLMSHASISPAVRAERGLPENLIRLCVGIEDPRDLITDLEHSLLQSGAIVPNASYIPVTHSKAAELYAKDTEAWILERAKGFKRPSDATVVDKLVTGVKQSLGLGEPSKEYQSIKDDIVLSAPGKVILFGEHAVVHGVTAIATSVDLRCFAVLSPRSDGKVALDVPNIGVELEWDIHSLPWGLLPVHPRSDKRVADKDLDAALLQAVEGAVNQHVEVGKTGIGAAVAFLYLYMVISGGESNAIAATFTASSNLPISAGLGSSAAYSTCIASSLLIARQYISATVRSPEETDLVDSWAFLAEKVLHGNPSGIDNAVAVRGGAVAFTRSVGGRQGGLDGLHQFSSVRLLLTNTLVPRDTKSLVAGVTNKRLAEPHVVDPILDSIQSISDEARALLGGAQPVPRQELVKRLEGLIKENHGHLVQLGVSHPALEMIVASTGQEPFGLATKLTGAGGGGCALTLIPDNYPEETLTQLIQTLEGHGFQPHLTTLGGPGFGVLVSSESSDAVKTPGSGEGMVVPKRAALRETSKEGLAAWAENLGAWVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMI7</accession>
    <name>A0A1E3JMI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033341.1">
        <property type="nucleotide sequence ID" value="XM_019174962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMI7"/>
    <dbReference type="GeneID" id="30192033"/>
    <dbReference type="OrthoDB" id="2594273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="43278" checksum="4E89400389BAA0C8" modified="2017-01-18" version="1">MSPSIDYHDILRQADDAFPSLDAHVHDTAQLAHVVDQHEQQHAHLSQHHEDVGELGANGAEYGMDIDQHPLDAGQHEQRQLEQAQAAVQQQTEQRQPSPVRQPSQHELPVQPQAGTSTQKSKGLTAEEKKERQRLQNRRAAEKSRNKKKNEQMALEQNVAGMQEENQRLRARLQSLIAARPSDASVEPTHVDQLASPVPAPPATVIGTGIDYVYLSKLHNELANSKGSLLEKSADLSRMTAGDDGPLNDEHRPLRLELIANLTKLAALRSEMAGLENVMTHVVQEKQNMQVERAKVERELAGRRVARERSAVAQQAVQDDPNIDPSLHQADPEGAAVAHEATGVQDEQADEGDDGQPAEGGDRALLDIRGWIDAAVKDWHQDDPDQDGSGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMM4</accession>
    <name>A0A1E3JMM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033356.1">
        <property type="nucleotide sequence ID" value="XM_019174977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMM4"/>
    <dbReference type="GeneID" id="30192048"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="489"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO02104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="855" mass="92682" checksum="2919A9ADB6A59241" modified="2017-01-18" version="1">MDRRQHARRSAQGEEFELPLTPGSATSSTADSKPADGPGVSKSPSLAPSPTRPLAAKNGAGKGPSKIMARAAMFENSDASASPPSKKGEAPKKLKPPTPGASPGFRSIPPGGGKGTGLTPRKLSPEKRSMGREPLVKSPAKTPSPSKTPSPSKTPLPAPVPEPPVPSPMIEAPVTGDISKDQTGETPPATAAERFSEIPLSATVPKSPAATASSSPVATSPNDLATASPSSPSLPYLDEPEDKGTLRISPIPSKPSNLPGISTDSDVTPPAREQEKESKGFFGSALGFGMPSHAQPWKPSEESLSTDITSPPTEPPSTSAGWRSTMTHLLTRSTSGSALTPPIPARTPSPLAATSSTLPSTSHPPVPQASVITSSPTAVLLHGPAATPIRDRRLSKDIVALGVGEKSQEGFQRVRGEMDSAAREMRRERDAKRSEQSSPSSPRPPHSPIAEAPEGAGETDWTFWGSVVQTYEDIAVNQPKELSKAIQMGIPPVIRGAIWQLMSSSKSSDLEESYKALLKMESSHEKAIMKDLNRTFPSHKVFKESGGLGQEGLFMVVKAYSIYDKEVGYTQGLAFIVAALLLNMPDEEAFCVLVRLMTSYNLRSHYTAEMQGLQLRLFQFDRLVEEVLPLVHTHFVRKGVKSSMYASQWFMTLFSYRFPLSLVYRVLDIVFAEGIEAIFRFSLALLKKSEAKLVSLEFEQILNYLQTDLYEVYKNSAQDEPAKGGEDDDGVWRADEFVRDAFEIRITPLMLDAYASEWEEQCRAANRHAMEVDHLRNINRTLSGQVKQLEGSLAAMNQEHVDLVRQLVMSKIEKEETENELVRYKMLYAEMAHAQQDALSVHSRLSSGSATTSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPJ5</accession>
    <name>A0A1E3JPJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033084.1">
        <property type="nucleotide sequence ID" value="XM_019174705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPJ5"/>
    <dbReference type="GeneID" id="30191772"/>
    <dbReference type="OrthoDB" id="2576586at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130481" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="25237" checksum="E1B5FAA9236601EA" modified="2017-01-18" version="1">MVSVSALFAALSLAGSAFSQSSTASDYTIQTSPASESASDSNTSGGADSTALASMTSALINNTSSSASSTGSGSSAASSASAVAGFPDSCGSQCNNISTSLSTCGVGTSLNTTCLCTDSVEAAYRDCLECALGLSPAETTRATYQEILDTFVSQCALASTSPVTLPSATITYPASVNTSTLAPLTTSNGSSATANSSSTSSSSSGSSSSSAVSTTSGGPAATSSAATSAASSGSSSGARRLFPEEGILGLGLGVVGLLGGLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPK1</accession>
    <name>A0A1E3JPK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Bacteriophytochrome histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02569</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033094.1">
        <property type="nucleotide sequence ID" value="XM_019174715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191782"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="936"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1312"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1709"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="765"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1544"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1613"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="770"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1548"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1632"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO01842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1871" mass="202978" checksum="0ED89681FF756FED" modified="2017-01-18" version="1">MSKLPPSTPDADRSPSPSHDDSQSPTTIADTFYSFPHRGDRPGHIVAPAYSPMGSPTGPLSPAHSASSFVFPIRSVYQGMVTSGSQRSDGSDPPRKSSGNSTQSYQSGKSALSPGWERDRLEDPDAGIKSIAQLLQQSQQGQQSQQGQQGQESQQGQQIQQDGSDTHQLLPRQRQAGAATYHSKHDRERNTSSGGGDGMSALSQYGDSAVVGDLSTPYSTEEDGRRPSLPFVEALAGLELGGDGNGKEEDAKKEETEKPDSDGGERPTLGHSGSGETVKQAFDGGDAIHNPVSTPDASAGPSSASHNYRHFPNKDAPSQATPDADAHTSPRRFSSIKQKRGSPARTTPHAPTQQPGVELQHPIPQRPSSPSSKANKAAEKSRKARGTSSHGSKVSIDVDESGVRSLISDLSGIVRLGDVGSFNGSKTGTGTKGTSGTDGSVEHSGFNSANADHVHGRAELHGSGPRTKRAKFTARQNSVRDFVQDQAQTTNLQDPNAPTPSPTPHVIEEASEQEEGDGKTPSQLGEELSLPATPSELHQPLGSERTAGESQPTAAGVSGDPDAPDEPAVTMRFEHVATEEGHHIVAGREGNLKKCEDEPITTPGAVQGFGVLLVLEEDEETGDMPIRQVSENSTEILGLSPKYLFKLDCFTRLLTADQEDNLRDILDYLPALDRSSGETAIEDDGPSVFLLTGFGEPGSEEDGEEGGSIGSSAGGKRREWRCWVAAHRPGHKNWTKKDADGKDVPPPNLIILEFELERDVYNPLFDSGEASTAPTSAASPARPSTPDSGNTASNNSGSARTGGDRSLDSLAGNGAGPRAGGSKGSSSTVSEFTTLARPHSSSQTSFTSMPPLSDDLMGLEGLDMDMSPERIMESTTNHAKPLRALERMRGKTSEVIEGRNKRKGRPPRALTGTSTGTMDIFAVLGQINDQLGSAPDLETFLKVTVGLVQDVCRFHRVLIYQFDEQMNGLVVSELVEWGKTTDLYRGLRFPAADIPPQARELYKINKVRMLYDRSLTTARMVLRHKEDLDYPLDMTHCYLRAMSPIHIKYLSNMGVRSSMSVSIMAFGHLWGLIACHSYGQHGMRVSFPVRQMLRILSDSISRNIERLSYAQRLHTRKLISTVPSPAHPTGYIVSNADDLLQIFDADAGLLVIGDGCKLLGQNDQGHAMLAIAEYLRIMKFGNIKSTSSIVREYPDLLLPRAPDTIAGLLYVPLTAKAGQDFIVFLRKGQVRDVQWAGKPFKDEQTGKAASLEPRKSFKTWTERVTGNSRVWTDDQLESAGVLALIYGKFIQVWREKQSAMVSNQLTAILLSNTSHAVRTPLSQIINTLELALAGDIDADVRKMLENSHQASRALLFHVHDLLDLTRIETGNETAFNDPFDLRQSISEAVRLYETELIRRGIDFRVKIGDGLPQFVIGDARKIRTVISNLVANSVKFTPEGFIEVYCGLRSHDNGSCTGLSFDNSVHIEIVISDSGCGITNEKLEEIFVTLEGAEEGMQKSSGVGLGLAVVARIVEQLDGQLRAESEVGVGTRFFFHLPMAIHDPSNPKSRSSRAGSSQRASRADSSSSKSLVSLRSDGSGVPEIDSFVQDLQGSHMEHAPEDDERLEAARKRMSEPGVFPVTDSSWPIRPSKMSTEAQSVSPTSMSPDNSVPKRKSPRQIQARDSRAAKRLTSGDPKTDTHVPQSSVDGASAPPPHRSKVGSTGKTLMRIMVVEDDAINSTILQKRLRMDKHSVIAVTNGQECVDFLKRDRDIDAILMDIQMPIMDGRTAASEIRKLESEGKAQIEFGSFTVDGRIPIFAVSASLYESDRSNLAKNFDGWMLKPLDFARVRDILQGLESSKKRKENVYQQGCWERGGYFRSAFYVRVVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPR9</accession>
    <name>A0A1E3JPR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033154.1">
        <property type="nucleotide sequence ID" value="XM_019174775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPR9"/>
    <dbReference type="GeneID" id="30191844"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="615" mass="69298" checksum="38F532DB9B21B81D" modified="2017-01-18" version="1">MLFTRRAALGLKSRHSVRTLTNSPSPPPTRPNGHLEEGKETLFRNMRYLPAIGAVSLTGVVIGVTAYCLTPLEQSEEDKEVPFKDTTIFSGTPARIRSIDGQQVEWRFEDKHYYHPLLSDRDAERMLTPGHKVTEVNRRGNPLKTFDFKILFSADTGEDRCNFEVVTRSDLAGVAQKSGKGEFWWKSWWDARNRVYPKGRNRKPKVGDGSEDVIICSVWDGHSGHEMAELLKRGLHGCLAWNIGKELNRSKGWTETIKTSLGFESSSGESFRDVHFEPESFSNLISNTFLAVDQDVVTAPSRILYSGPSNTLSPHLPPHLPSSLAYGAFAGGPGACCATAIVDVADDRFYVANVGDTRCIARWWNEADQKWRCDVITEDCMGDNPKESARILSEHPEDEQDTAMYNGGNGNGNRVLGQLQLTRVFGDSDYKIDHDDVNRALDQCEYGIRWPRFDEVPCKTPPYVAAKPEVKWRDMHPDNGDELKFLMLGTDGLFDRLTSEEVSHLLAGHHSNPKQDDVDKVVLPMLHPHYESLSENEHPFPKEEMQTEGGWVFEDKNAAIHLIRNSLGGADRELRRQFLSLRKPGVRQARDDITACVLWFDEKGPREERGDMTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JQ86</accession>
    <name>A0A1E3JQ86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033334.1">
        <property type="nucleotide sequence ID" value="XM_019174955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JQ86"/>
    <dbReference type="GeneID" id="30192026"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="310" mass="33871" checksum="3FACE2C7D03D3507" modified="2017-01-18" version="1">MTNSSLLQTALQNLHVSQQIHQQSHTPNPPSSPGSTSSRLSSGANTPPFSDYDTDEDELVAVGKGTRPVTPTGGKFGGRLPSLLGGKSRDPLRVLPTHLSVRIFLMLDIRALARCDRVCKRWHKSSTLNYVWFLQNRNLLLPRISAPEGDKGGKTRKVDDEIEFYDPYDKSPRLSSLPPPPIPSSAQPQWTKIESKKEWKKAFKHTFKRTDPTAEPEPERGRVDIASLHSSGYSTPTGGHGYAGMGSGGASRWEPVAGEAPSSTERKLAARDAYKALGGRKSRVKRKMGGDMGSKDKGGALDDGRFDAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH8</accession>
    <name>A0A1E3JRH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033484.1">
        <property type="nucleotide sequence ID" value="XM_019174432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH8"/>
    <dbReference type="GeneID" id="30191493"/>
    <dbReference type="OrthoDB" id="2571050at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="516"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="629" mass="69741" checksum="9DCD98A477C9C4FF" modified="2017-01-18" version="1">MESLIALGDMAYSQSTPTSPTTSVFFSSSSALGGEDLDDQGDVTMTQELSSAPTLESPIFSKTGRNSSSLEEGDGENDQHVSSQGRLGKRARALPNSDSTAKRPRAPTPHLAPPCDDNLDNVSEQSAILAAFAALQGTLKFHQDISEQSLRSFTKRLDRLQIGFEREMREVKHELHNNNEELRQVRGILKSLGLTSLVTVPETIAPVPTTPLTHHVTDSAARQVTPAESAFSGDKYIGNAMREAGIHTLVVGGQGRTVNFPFLSRPRTKKDRGINFSDTEEDTMTDHPSTHGDTNFGSENDESDLSSSSQPSPSQASDVSDATCRPAERPTMIRMRSPDIAPDSPTPTANQVSSPLVVEREEEGESEIGSDDPLDSVSNSVGMSRHGELEATKANRSVRGPSLISEQSLLPSDTAQRKDWVWKCQGDNTAKGRNWILECRGCTGRVHWACAGFETMTKWTKRDIYYCPGCWPLLGKAIKQQYSKQQATVEKAQQETCLRADCILHHDPVEDDDDQFAFESVVGRRYRKKGDPETVEFLIKWEQWALWDSTWEPPSALADFPYAKKRFEKQARAEGNSVGAGAFGERVILLKEVQEYFLPKTGKYNISFLKEKKLAHREWWDVEEKRAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS33</accession>
    <name>A0A1E3JS33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low temperature requirement protein LtrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033715.1">
        <property type="nucleotide sequence ID" value="XM_019174663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS33"/>
    <dbReference type="GeneID" id="30191728"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56271" checksum="689A8F140F68A009" modified="2017-01-18" version="1" fragment="single">MTGTPTADNGALSTSHSQTLDIKVSRRGAFGGEDHLVYTEEHGEEEFKPLRVRELVRPPVVRQWMEDGKLYREPSHHETPRIELFFDLLFVAIVHQLADAAIEEPGGKSVARFVLTFWPSFQTKAVPMMHLLHRVWVLIGMMTLIGYSANASAIEIHPEGEEEELDHSAVRAAVAFWLVIKLTRVVVLFYYALKLPKFRSAHIWKAVAVLVPMFVLLPLIWVTSRPAQIVLATLLIIIDIMRIDLIFLLIRGRIHAYRQRRQEGIKGLQAWGFKGWHRMPDVKGGGAVPVVNIEHATERLGAFIVIVLGEMVMNVVYTAANGEMGVSHEFGKAALGLMVAWALNYLYMLPSEPSAEYEHAFRRSWLTGVCFNFFHWPLSASLVLASAACGKMVANDEVETGVHWYWGCGVGFAMLFIALLDLTHFDLAPGEARIPRSIRAILCLAAALSLILFSFGTEHMPSTGILAITVGITWFTLAVSIYGQLPKPGGVTTQEREELERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU28</accession>
    <name>A0A1E3JU28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033698.1">
        <property type="nucleotide sequence ID" value="XM_019174646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU28"/>
    <dbReference type="GeneID" id="30191711"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15755" checksum="BD5E4C4A72F05C56" modified="2017-01-18" version="1">MPYGNVSTTKMAEPFEPSPQSRPYRPLSGSIVHEELFAGTRNHPLADSSSSSSPEQSQKPEAHDPQRKKIDDINKEIDATKNVLNKNIEMITERGERLEHLDQRTQALGISSQSFKTQAAVTRRKMWWKNMKVRSQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU40</accession>
    <name>A0A1E3JU40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033493.1">
        <property type="nucleotide sequence ID" value="XM_019174441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU40"/>
    <dbReference type="GeneID" id="30191502"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="239" mass="25647" checksum="362413DB7342846D" modified="2017-01-18" version="1">MSCCSNLPPVQADYTPKGTYTTSIGLKSYVTGPEDAKAAVLYIYDIFGFSPQILQGADLIASQGYRVVMPDFLVGKYATPAFFGPGTEEKRKEYFSQFPAAFATQSKPLADSIAALRAAGYSRVAVLGACWGYKAALTTEGLPNVDVFLATSPVFPVPEDAEKINVPALVLSTSGEDKSIIDAIEKGVEAKYPGKNVFKRYDDQVHGFTAARADLSGGATLAAYAEAYQLIVKFLKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWB0</accession>
    <name>A0A1E3JWB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033799.1">
        <property type="nucleotide sequence ID" value="XM_019173992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWB0"/>
    <dbReference type="GeneID" id="30191045"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="848" mass="91997" checksum="A883C7784BFCED75" modified="2017-01-18" version="1">MPPPTAPFSTDSPTASSSRASSLAGRKRPRESDGDSKTRPRRTKSTGDSKDGRTTSSGAKDREAFQKGLIAVFVPKALQESKQGNLSHYNDLLAHFLPTPTQPIPLLPPLLPLLRAVSAHVSLLAPDVHSGLVSAIISLPWATGDEKFVKTFIGFAAVLVSAQPGWAKEVVGMAVKGLTWQPTHPTATSLPRRTFHARHHLLLSHLISLIPTLPNVIQPLLIKNFPNKREPEVAQTTWVRNCCELIGYCPELGGRVWGEIVGRMLRIDVEITNSTEDDEDDSDDESDSEDMPQFPKAYLDPLDLPISQDLPRPRSLSPDLPGSLGVDDEDSEGDPDPDDLSSADGAESGDSDDEGVDDRKAEAERQKKIANVKSMREKLDGMLVHFFRHISEYMGNSYPHFSAVDLAAQGLASSTSSGRSTPTFEVPASPFAPRRPVSEAQSLAHFQTLLNLFSRQILPTSATQHIPFLLFFTSSFSPAHTDLFLGLLVSQALYATNSQPSPAIPGLGNVSMNQRTAATVYIGSIVCRARFVSDSQARTVLTYLLAYIDGKLHQSRVLAGKGVDELPLFYAVCQAVMLIFCFRWKAFTATAAAGEGEGDGIVGDMDMDGEEGLQPGSGEEGKWMADLDILQRAIFSDLNPLLGCNPTIVQTFAKVAQKAQFAYCFSILGANSQSSHSRSNSSHSISTTAKSSLPPNGRSNSGSGMARNSAASVAGHAAQTLPRQARQVNVEAGLDSYFPFDPYDLPKSKKFVEGLYRTWGEVAEDLDSDSEDESDDEEEEEEDEEEMNEDSELEDHLPHRGLPLPLKIGSYGDHRKRAWGEKSRDSGLSTSLEGMSISPGRLGVDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD4</accession>
    <name>A0A1E3JWD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033819.1">
        <property type="nucleotide sequence ID" value="XM_019174012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD4"/>
    <dbReference type="GeneID" id="30191065"/>
    <dbReference type="OrthoDB" id="10322979at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="370" mass="41685" checksum="6F05266FB55B137F" modified="2017-01-18" version="1">MSDSSTGEELTYHPIEDARSLRSLTDSGDSAPDSLANSMQLLAVPSGQTMSGFGSPSSLRSPNLSALDHRRSLQDDPTWTAEDSENDGDVESIITTYSQLPGTLALPSFQVNFPDGNTPRQLTMFDPSKDRGFVVPRASPSDDDPVDYQVILSIDEWHQIYALWDDLAFPRSRINEDGQEEDDGFARLRVIFEKQEKAWHLDGSLDQFMFEIRAMLSTFAGNRDDDDSDVSVCLYHGNPLVLTEKSLDANVTETTEDFSIVCEDIKLSEWFKRLYNRAREQAAPGESLNPMRISLHVGWHKTQTVEGFAAMEEREKERQTRLGLPEGRLGNELDMDAVRMARESVEEEEKEKERVEKASKHRVNGDDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF9</accession>
    <name>A0A1E3JWF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033788.1">
        <property type="nucleotide sequence ID" value="XM_019173981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF9"/>
    <dbReference type="GeneID" id="30191034"/>
    <dbReference type="OrthoDB" id="2595432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="40195" checksum="36F214F5D18DCE46" modified="2017-01-18" version="1">MSTCWWESLVVQSRDIPAPDSVVTFLRSEIAWREIFGVAELTHLIGFLQELLYITPSVTADLIKTHRFEITLHRLKPELDSLWRRQAEDLPTYDIFREGEGEALTEDELREIRWRMEFDHVKLYANAIAMRAAQTRSRNKLQHPNDTVYHTNVMTAVEGPFILEAVDAALSLVRCGIVMGKKGVLRYCPCRVFTRLVFASVFLMKAVSFGAIGQPDTEIIDLEYTLIDSLAASSADEHHISAYLAKLLSKVLESIPRRGMAPGRLDPGADEVCLLFNSHLEGQGSRSGAPDMSSGLAHQPLDFGVGGSAHSGTGAGNVGVGWEESMSMLFDLGYNPTSIVSDIEDMLAASDPGFFGIETGGLGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWV4</accession>
    <name>A0A1E3JWV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">30S small subunit ribosomal protein S27Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033945.1">
        <property type="nucleotide sequence ID" value="XM_019174138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWV4"/>
    <dbReference type="GeneID" id="30191195"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000297">
        <property type="entry name" value="30S small subunit ribosomal protein S27Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="17474" checksum="FC0535A2D0094893" modified="2017-01-18" version="1">MQIFVKTLPGKTLTRDVEATSTVASVKAMIANAEGVPAAEQRLIFSGVQMDDERALASYGIQKESTINMVLSLCGGGKKRKKKNYTTPKKIKHKRRKVKMAILKYYKVGSDGKIQRLRRECPAPTCGAGVFMAWHKDRQACGKCGLTYTFEEGTKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYB5</accession>
    <name>A0A1E3JYB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01886</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033852.1">
        <property type="nucleotide sequence ID" value="XM_019174045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYB5"/>
    <dbReference type="GeneID" id="30191099"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO05197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="39613" checksum="A81DB7F3730F95B3" modified="2017-01-18" version="1">MASVLRQSLKLGMMPADGIGKEVLPAAQRVIEALGSAIPRTTFVPLLAGWEEFNRRGKAMPQETLDALKECDGAMFGAVSSPSHKVEGYSSPIVALRKHLDLYANVRPVSSVPIPGQDSSKKVDLVIVRENTECLYVKQEEISGEGEDRVALATRKISARASSRIGRMAFDIAARRGQEREAARAAGKDVLWKGEPKVTIIHKSNVLSVTDGLFRETVRAVKEGAGGEKYNGVKLEEQIVDSMVYRMFREPEFFDVCVAPNLYGDIISDGAAALVGSLGLVPSINAGDNFIMGEPVHGSAPDIEGQNIANPIASIRSAALLLSSLGYVEPAARINAAVDAVLIEGRYLTPDLGGKSTTTEVTEEVLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYR9</accession>
    <name>A0A1E3JYR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034012.1">
        <property type="nucleotide sequence ID" value="XM_019174205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYR9"/>
    <dbReference type="GeneID" id="30191263"/>
    <dbReference type="OrthoDB" id="10302286at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130642" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17492" checksum="05993F4AEC414DFD" modified="2017-01-18" version="1">MFSNRLVPSFLLALATTLPFSYSAPFDEEVQTLIESRIAASNDHPTLDIRVDDEYSKLQSHNANEGDGEGQKRPYGLLGHGDVEFKFYEPENYKQETFRVSYFEPPTTSAGYQVDDAWETHSATKVIEAMYRLGDCESHGKRNRKAIRRVDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ60</accession>
    <name>A0A1E3JZ60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034191.1">
        <property type="nucleotide sequence ID" value="XM_019173486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ60"/>
    <dbReference type="GeneID" id="30190535"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="576"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="665" mass="70508" checksum="CE2B0690E0058C3F" modified="2017-01-18" version="1">MGLNSPIPVRLQDESRKAAKILRSFVDVNNNGLDKVIPRTVLERAEGFAIFTVFKAGFLFSARAGSGVVVAKLPDGSWSPPSAIGLGGLGFGGQAGAEVTDFLIVLNSHSAVASFMSAGSLTIGGNLSVAVGPLGRNAEGSGALNSKGKLAAMYSYSKTKGLFGGVSVEGSVIVERQDANRMAYGGNVSSKQILSGHILDGIDMPDWAFVLLDQLEKCTALPGGQKWINRDKENEEGGGGMGWSTPESGRGGGGYAFSEGSAATGSTPPPNRRRAGSLFGKDKEPSRSDSPSSNRRGSILNPFNSGTSSPRKGSLGPGHTSEAYTAGLTSDSQGPMGLGVGHGSKPSGGRARSGSLLKDGEVPVPFSYMKEKKDKDLLADWDSSSHQKTPSNGSSTQRDLLGQWDSDGNGLNASFSRLSTDPRARSDSRSRPPFDNILEHPKPSTSTFYTSVSAEPDYTPRESVSRYAGMDLAALEAQRAKQQDERARYGSPSKKNRPFSSYVASAPKSSRSEFSPFDDDSTGRLRSDSYSKPFEDYQKSARSIPSPWNSSPQKPSSSSSPKPEIRLKQGLDDLNDGYARAVALFDFKAGADGDLGFSAGQVVIVTDSVGEGGQWWEGRLASEGNYGRKGIFPSTYVEVLGLPKDLKGGVTRSELRKRIARDEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ88</accession>
    <name>A0A1E3JZ88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034196.1">
        <property type="nucleotide sequence ID" value="XM_019173491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ88"/>
    <dbReference type="GeneID" id="30190540"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="15735" checksum="41BA01F552BD9EC5" modified="2017-01-18" version="1">MAPKKVRAPQEAAVSLGPQVAEGENVFGVAHIFASFNDTFVHVTDLTGKETISRVTGGMKVKADRDESSPYAAMLAAQDVAVKCKEVGITALHVKLRATGGTGTKQPGPGGQAALRALARAGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ91</accession>
    <name>A0A1E3JZ91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034239.1">
        <property type="nucleotide sequence ID" value="XM_019173534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ91"/>
    <dbReference type="GeneID" id="30190584"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="258" mass="27984" checksum="99BF6C96B094F311" modified="2017-01-18" version="1">MRLTHEYVSNAPSHLNPLKERELELRGLQIPVIENLASHQGSYDTLNLSENSITVLGNIPNSPRLQAIHAAGNQITTISPSLPPNVSLIFLTDNVISSLASLIPLEQLKSLRHLSLRGNPVTQQEHYKEFVVWKVAGGKLHTLDFERIKDSLRESSRKLLIDPETELPNSLAHQLSIPTTSAIPASSSAFAASARVNADGAGAGVKGGKGRLMTPDEKRRVVEALTSAQTSEEVRKLERMLADGIVPEGGMDEAIGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZE7</accession>
    <name>A0A1E3JZE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034253.1">
        <property type="nucleotide sequence ID" value="XM_019173548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZE7"/>
    <dbReference type="GeneID" id="30190598"/>
    <dbReference type="OrthoDB" id="10370067at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="16701" checksum="21F668F98D089E6F" modified="2017-01-18" version="1">MSSSHPRDTNSTPSQQDTTTDGANASSSTSRNRPQTPYNLSTTSGPTAGGTSPASQYSASPASVFSRSANSPTTTRRSQHRPYDHGRTASNATAVTVPDVDPQQAAHQANIQNMVHQGHFNPHNEEEEVQDDIGEFIDDMFPEGQDGEGGQDGGGGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZI3</accession>
    <name>A0A1E3JZI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034321.1">
        <property type="nucleotide sequence ID" value="XM_019173616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZI3"/>
    <dbReference type="GeneID" id="30190666"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="439"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="848" mass="91120" checksum="A03CD78A8F05A199" modified="2017-01-18" version="1">MSRPPVPNRIHQLPVRVSYYIPHSDQSYSIIFPTLLNVYIHPSANEAGDEVWGSTYLKMVVKGVLGASPELYPAYPSASDLSLYVLDPRETFFRQTRGQGSTDRSSNSEVWTGKGLVSWALAEAGIGKNLIVGRLQEDVAFANIGKVSHLSALEQLMEADRAGSKGEAGWGIDISMGLNLGSGGPPAAFRRSQSSSRLVRRSSSVAAEEYQTQRSRPNVSRHLYDQAGSSSGLKPEAMSRAGSSTSRTGHVSRQLFSSEPASLPRNAPLCTPDLGVSSPALTPCPHPVSNTLVREPSQRPTPLITRPGAMVPRSVPPKKRAPPRKPPAPSSDNPILHDAFSSLGENCLGEPDNLTREEAQRLLANPEFLSILGRITGTSYTGPSDPQLGDKRKRADEDGNAQPKKKRGRPTKAEKAERDARAAAQALAAKVKELAEAPDREDAACWNCKRTQSLIWRTRVLDDGKRIRVCNACGLYWNKAGTMRPANLWVADDDEESRAAGRLPASATGYLNQPTVISINRSQESFKRTLSAAVNQDAERLARHKGRQVSTCKLGPMTSPPRGSASASNSFRQSAAVSSPGKNLGVFDKSFEAEGTDASPKDAPVLPKSVPHPQPLRHNAPVDSTIQTLNLPLSDDGPHGQNSGQVEEWNDQVSAFFDVEGFSMAPMTDGLLDHRPSISIHGPHRSIPIHATSSSMIDNHMPTDSSLEEDTVLSELFNRTSSMAESSPIAFDFSQLPPSSPPLSVLSSDALPHSALLLSSPMKKYSPSVSGQTPSASGLTPVDASRLLPSNSKLRNEVEDDNEMGLYDEIMKSMGGMAGGVDKEGETSSVSAQLHETSGEGIFAAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Q9</accession>
    <name>A0A1E3K2Q9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034592.1">
        <property type="nucleotide sequence ID" value="XM_019173887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Q9"/>
    <dbReference type="GeneID" id="30190937"/>
    <dbReference type="OrthoDB" id="2572347at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="728" mass="80691" checksum="52EC0BBB94B6556C" modified="2017-01-18" version="1">MPFSSSSTDSFSNHLPPSPPPVHPAPAALALSLRRHLSDQSFASPKGKPKLRLRISQWSVKNRKSKGEIKRRNQEERKAEDRDEEEYNFMRANGLLAPEEYEWERKLEHRTSVARLGGKGVKMKMISLPSISTSPSAFSFPAPPPRDSISKSINLDDYETKTQSLLAGQFSDDSTQTMSLSGAGEPEVESEIESEPEEQATPTAVLKVAVGVPAIVRSIPSMNSFMGQPSFVLPEEVDIFYRGGSWSDELGEGGELEAIPPPPETKQVPRAPSQHLSVPNSRSVPARDGQFTDADSYYWKAEDGQFSDIGNEEAHKPAEKPLPVAPRDGHFMTTLKSSRPSIGNLKPSHVSDLFSPDVTGVTFNAGEDEDWSESTPGYHRRDRMISSKFYEHCETTFETEECDTTAGALMVRQDSHKLYRKEYIGSDGSTTTLKQHRRTTSVGSTSTDATARQPEWPLGTALTQNLLQKAATKDAHVRTHSDSAPPRPSTDSIAVRILSGTVKKKKPPRRSVDHEASPAGNSFDDVDPPREDVEVIESGLSTHPSIRRPSISSSVVTTERISFSAPRAVRPSHSIRSKRANSTTQAPEPRASSTYTRQSVTRSHTDSSVPRCLLDLSHIYAPSSKQPHHPVSQNKPHRKIHDPFAVFDPYPPIVPVKQIPNDPWIMITSSMDDDMLRKKGWKKVEMRRLEGEGFWAWMNRKVHGEGLNEARERMLAVKGEGVDGAVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K353</accession>
    <name>A0A1E3K353_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenazine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034952.1">
        <property type="nucleotide sequence ID" value="XM_019173226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K353"/>
    <dbReference type="GeneID" id="30190267"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33778" checksum="202C3926A9633314" modified="2017-01-18" version="1">MPDPAPLPVYLINAFAPTPAYSGNQAAVVIFPSDTHPKTQDEAFMLSYAKDFGFSETAYLVPMPGNGEGGVGKYGLRWWTPGVEAALCGHATLASSQAVFSTNPDITSIEFFTRYSGVLTAKRIEDSIVITLPTLSKDTYAAFGSESAKDPKKLEEAADVFGLKTGNVESVETYSFGDRTSPIVQLSPETDITRIDVVWDKLLAFSSGLIIVTQLATDQPDDRLHINTRVFAPGLAILEDPVCGSAHAYLSGYYLASPRTSELLPQKFLEDPSKVLIGGNQPSPRGGRMTCALGEGNARLIGKCREFGRGTLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4Z8</accession>
    <name>A0A1E3K4Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035135.1">
        <property type="nucleotide sequence ID" value="XM_019172193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4Z8"/>
    <dbReference type="GeneID" id="30189216"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="110" mass="12178" checksum="92FDFA066E5CF9D3" modified="2017-01-18" version="1">MAETSAGLFLRPAPSVQADASSPRKGAQEAVTRKKTHRVMDAQSQLLGQEGAQHNIVLPALGRFQHRFVADGELDRDMLKVEELGVEEHALSERVDRGDEQESFAGPVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K575</accession>
    <name>A0A1E3K575_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035124.1">
        <property type="nucleotide sequence ID" value="XM_019173398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K575"/>
    <dbReference type="GeneID" id="30190441"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55092" checksum="24EAFBF8A078BF54" modified="2017-01-18" version="1">MSPKSKLRAPPPPAETLDTRSSSSSDDGEELVMAVRHPEGEESDAEEEDGLLRSEIDEREERQTWVLEHSVGPHRRNGRITIRGFSLPKPLLYVLCLLPTLIILNLIFSHSISSSPRHPTLSNGTHAYHPTTLLISLDGFRPSYFSSHADLLPNLHALASHPAGLRAESMQPVFPSLTFPNHWALMTGLYPEEHGIIANDFWDPDFQGGKGGQFVYTDESKSWDGEWWKGEPVWSVVEKMGRKAAVSMWPGPPVTSEGVSASYFNLAPSPKVDQILQWLDLPLSHRPEFIASYFPEIDQAGHAHGPDSEQVEDALGSLDGMVGDLVRGLEGRNLTGVVDVVIVSDHGMTRTSNDRLVFLDDILGEGMKDIEHKDVGIRFNPSLPPSTLSAHITTLQNAAAQSNGTFGVYTRQNNIFPDMQAIFFTRGPLARALRESRVGLVEGGESGVPVLQSFKNLEIFSLCTKLLGLRDVEPGHNGTEGFWERWLGLDVSTSIEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K586</accession>
    <name>A0A1E3K586_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035167.1">
        <property type="nucleotide sequence ID" value="XM_019172225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K586"/>
    <dbReference type="GeneID" id="30189248"/>
    <dbReference type="OrthoDB" id="2577201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="408" mass="45764" checksum="91AE260651FC850A" modified="2017-01-18" version="1">MSSAFRVTHTTDILHIIFSHIPDNKDLASLLRTSPLFFGLIAQKLYRSLPISNVLNPFSGVDAGGRGGPYGKTKLLELVQTVVVERVPLPIDHPVWANWYKLPPLPAVETVIIHPADRNARQEGGQDTTLPNNALIERLCPTATRLHLSTPCFTAGARGVQSMPSLPCVKTLVVKANAGEIMELKYVVGKLNYGLWNHGQKERPPCLNIKAVHILLWGELVYPDAKLQSSDWDKDRVDKLAIMGLSLSTKVKLRDKIFHNLCEIAERLGTRFSIDELWLYNVGTVLERLSKWSTSRKVDDMKAEVERAFEGEMKTSAEYLGMPEEAAEAQVFWRTGLEFYEAFGDVSARDETEEWYHSAVLAPSPNLVSLRARLAAKTKFPADTFVGLTEREANGRWQLLSRTRYTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5U6</accession>
    <name>A0A1E3K5U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035377.1">
        <property type="nucleotide sequence ID" value="XM_019172435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5U6"/>
    <dbReference type="GeneID" id="30189465"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="87"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="51983" checksum="1B6775EDC3E1DFA9" modified="2017-01-18" version="1">MMRSSLQSRLSSAVRTAELRGTQARPVAPRSLPAAARPIAGPSVLSARTFATKALSTPRFPAAAFAPIRLPSRGYAAEAGGKFARAKPHFNIGTIGHVDHGKTTLTAAITKYLAESGGGKFMDYSQIDKAPEEKARGITISTAHVEYETPNRHYAHIDCPGHADYIKNMITGAAQLDGAIIVVSATDGQMPQTREHLLLARQVGIKKLVVFINKVDQVDDPEMLELVEMEMRELLGQYGYDGEGTPIVMGTALAALEGRDPERGTEKIKELMEAADSWLDVPARDLDKPFLMYVEDVFSISGRGTVVTGKVERGTITKGSEVEIVGLGDSIKTTLTGIEMFHKELERGEAGDNMGALLRGIKREQVRRGQVLVQPSSIKSVKKFKAQIYILTKEEGGRYTPFMANYRPQLFIRTTDVTCALTFPEGTEDAHEKLVMPGDNVEMIGDLVHDIALEPGSRFTLREGGKTIGTGIVSEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K601</accession>
    <name>A0A1E3K601_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035302.1">
        <property type="nucleotide sequence ID" value="XM_019172360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K601"/>
    <dbReference type="GeneID" id="30189390"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="64643" checksum="D56260BA5280B39B" modified="2017-01-18" version="1">MRSSRPLVLLRRPQTLPLRPLLRRPLSSVPPTRNINHRTNEYTDSTIYAFSYLSRTIKYVLISLVGIGATGLIGFEGLHFWVEKVGMGAPSREDSGIDGVWGWDGEHQGWTGGPKGGTDPRLGFKARHALRAAWISQEWGAGSSASIEKGMHTSAFHPDYVAARSIITRTQADQAGGGVRKRVDRGYEIADEYVDLAIKEAKKKGLVFPPELSGARASGPTFDNDGYKGLHGDPAAMDLLLLKAGVLERINTFDSLAHAKDVYEQVLSSLSSSALAPGSVSPGGQAKVMRLASKVGDLCARTGSRDEATKWWSWGLGHVGIDVQRKVVGQVEGKPAAGVKDLPPPVLRATIALITSASAQLATTSSLQAASELQALGLTYLTPPPLIPANQTPAAELHWTWLTQRSSLLKLHLSSVLYALQKTNPRSLPLLAEAKEEAEEVIADINPMPKEYLDKSKATTPAAKLLARDALLTGAEIAFTRGLLLERTVSPAASTSSSWSIPFFSSLTTSSASKLRPTTLTTLQAAQKEFQRATALSLLESGADKRKKGPKEEGQEEAVVVGRGEEWAKYNRSLERVNGKIDELLGVGQGAEVKEEVQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K644</accession>
    <name>A0A1E3K644_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytokinesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035415.1">
        <property type="nucleotide sequence ID" value="XM_019172473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189503"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="262"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="949"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1658"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1691"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1816"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1859"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1664"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1695"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1822"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1876"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1891" mass="208510" checksum="A7A54D196E8A6269" modified="2017-01-18" version="1">MASLFGKKQRHRSSNSSSATSPTNLVAVPYSQLTSGPPPIAGPSTSRSDNSKLVSAPNTNPTLTDDGTPLNANSRTYGAMARPAPPPDTPKRRRTGDDMAGAGAGGGSGDRPRMSNVTDPGIHESSYSSRSGDGHQEMLQRSVSPYYDSVSSAGAASAIQRSHTSTQEFGGRSYVHPYAAMGQRNPETASVHTVSSMASQRSRIHVEDTDPGRYPLGYPLGPSRQQYTTQRESDGRTTPTQSPQPHVTTFTIPAPLQGRDEWQRPSDQVIEEWYRHLLQNTDLDPSSNHTTSPNPSLRSSVSSSTSRAAMSAAQVPVESKWMLVQQYWRSRPNAPGGRKQETPRVAGKRATKGDKGDKGSVEYFLSQLFNRDALTPALLSSLEISLRTETLDWIQNFMDHQGQAALGNVLTKLTYTNGVCEQPSAKDEGLMHCLSRSICKHRIGCNDAVTKPRTIERIILYLTCSNMNCRMWAAQILTVLCQISESNGDKPGLAVVYMAFDELKEKVNQGVLDIRKKVERFSLWMSQLAEVLEKQGRMGSKVRAHPLVKGLDVLEYCRTMVLLLVSLPSSNDAKTRESIRWQLELSGAPLVVARLRQLRDPEINMQLDIYEENARNDMANLVDSKKESDLKKLRSPEQIIGMLLEKTKGKTEGLYLLDILRHFVLIDAEGDERPRYFQLLSELTSTIVMGASPDLHGEFESAFHRSINYVLGKLAENKAYDEAMAEVKELRATNERLTYEREDLQDEISAGNDGLVGRLKAQITELEKKLYNSRVAMEAALDEKEGMRKDYEKRLHELRLWLQRLYNIIREAGLELPRGMEGMANIPDFSRLETEWKMVIDKDKAHDQTFEKLTGSSFHGKDGSRSSSLKRAIRRNDSTDVDDESEEEHEDGEVLEAAKVALSNVRGQRRSLKKRKSRTPGGKAKHVSVSQFEDAGDDSVLLHIENSLQEADSVSPVPRTHGQQSSRSGRLQEVITAGTPTRANFDPAAPPIGEKSVWRGQKKPSAFPPRFVAELRAKQISRSSSAPAQLNDLDSNSDHDDSDNRDSQYTERNTAYTSGVSEVLKTPGSRDSFRLQVLSKAKSVKHDLDLEKDFSQDGNALSTVTEDEEKSGRMLATQVPDESESMAAPPPPPPPPPPPLPPPGFLGPAVARGPTSSMAPPPPPPPPPPPPPPPPPGGMPRKPAAVPAGAPDMSNVFAGIKGGHSLKKTAGSTVPPPPPPPPPAAPSSNPASRAPLESVSSLLYGVNDSRKDVSMIASKRMKQLQWDKVSKAQLGKTVWKKAEDDKMEEEVVNMMKAHNIWDEIENEFKAKEVMYDAIKKRREQEIISVLAPDHRKRIEILISGPFAKTYKDNPEGLANAISEFDSELCVEAFLNELQSVLPNDDDRGKLLTHSADDPEQFAKLHPADRLMVRLIQLSHLNERVKGMLYRVRFPQNIDLLEQSLAVLEDACDALMDAKQFQALLALILTMGNYINGTNYAGGAFGFKIASINKLVDTKSSGGQNLLHFLEKTVSLHFQNIGEFLNELEIPATAARVNYADLQSTSKTMLDDIYRIRDALDKQFDGDTSQYTRKMNIFVTISSERVRNVRDGIIAADRKLKEVQTFYGECDDMGRGMQSQEFFGIFRTFVSSYKFCQAQNRARAEEQAALEDRARRRLERKQMGLTPQPTGMSTTSSTGDFEDTITKLRKNGTPRIPRERTKREFAPPPSPLSESVDLEKMMLAASGGGADGGDGGGYGMEPEYEALMAQRLLSTTFKSPFDSSEWSADVLNGMDEAKDPEEAGNDSLEDPDATQVYKLSAPPQSTLSMSDSSFAEGVEYVESSTPRATTPTSPLRDGPSPHTPSPMIEGLAGMEALIWPSTPSPTRETLVNGADADDGKLHARTVRGDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6B5</accession>
    <name>A0A1E3K6B5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035475.1">
        <property type="nucleotide sequence ID" value="XM_019172533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6B5"/>
    <dbReference type="GeneID" id="30189565"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000041">
        <property type="entry name" value="Protein OS-9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130798" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="19"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="145"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="521" mass="57984" checksum="33996E7EADB830D5" modified="2017-01-18" version="1">MPSLPTSLLLLLPPLALAFTQGPHHLRDLYAYPKYQVQFLNDYPISESVAKLVREVGLGSQSEWEQLIPGRGKRLGDDPTEKLDLIPMNFSPRDTDPSEAPHQYLCLMPSQNTTRSQLATLDQLEEVEDELDPAQGWAALSHLDGKCLYSKQGWFTYAYCHNSYIRQFRAAAHPHAHPTQGYVPQEDPNYEGYTLGRAQFDSSYERSQSKFSRSKVKGAKPGSPAHEAKKSVDSTSGQTSTSPSVSFGHGASSRYLIQRWSDGTRCDKTSRPRSTELQVHCSMTSSDTIYMIKEVAICQYVMIIHSPHLCGLPGFRAREAEVGGAGVMCREVVGDHEWEEWEKERSLAGAVKSDKEAKSEEQQSFSAKPGKELPNLRFGLAAAREKPKADEASKDSAEPNKIKQGVILEQVVFGVDKDEDIKAALKKALGALAQEARRESVDEGQQENEGEVLLLAWDEDDEGGAVLVEADMLVRDGEEEKKVGIKGGERELLQQILRQYLKGSEDDDEESEGEQRVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6C3</accession>
    <name>A0A1E3K6C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035270.1">
        <property type="nucleotide sequence ID" value="XM_019172328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6C3"/>
    <dbReference type="GeneID" id="30189358"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="804" mass="88828" checksum="7EC563B7FE0E9C29" modified="2017-01-18" version="1">MSQGYPRPNPHPQHPLYPSPVVLPASSDTIVASSPAHGITQHPDSMRRSYPIGLSSDAGLVGVDGSLKRRKISPTLYENTGGVQGIPTPITAAGFFQPPHQQPLKQSAPLNPVISTPALLYSYAQSAHAESQTHLQQSFIPPYISADRKSGYPIARLYPPSPPMTPPSPLATPLPRYTHDSEARQKALGYLLLALDLLRAGLKSNELSDREKVVFALEFGLVGVKVWSAWKSCSITGKERRKNESGRLMDEMQEFVGQASLVAERQSSLALLKLQLELLNARLAFMQGKFNLGKRLVRNGLAACKNDHCHRYGLYLLHLEHIETTGPGEYLNIVTEFLNEAERNKHQEIVQLASLLKARIAFVHRRWELVPSALAALAGALNSPFSDHTSVPANLLPGASELEQSWLASMNVHYLTLKALWEGRRGDDAVTKAVLKQVYALMDMSSDKGTFNALRASGGVFMLPLPNSQPLLIQLTPPNITYMLTYLTTVVTRREFTGSIASCRTLVHAKVFKETEHVARAEDMWDIGFSGCHGLADVVALQRKVASIRAEVSLEQATALMYRGSFKESLSLLYETVDYLQKNDIFAPLSPQLCLLFAQHAHLLGLTETATRYYTACKALINTGSELSLIAEIGILGAHSKLEGLMQDLMVQDEVNGLAEKCKGSTSATFSAAGQFLASMIDDNRVNSKKKLSTAYEISQKANNHILRLLIFAYTTSTHHYGGRQRMQRQLETGKDIAKMLGGKDRPDGVGQVVLGWWFARRLKEFYRQEGAAEAAAEAKQSEKVHLERLQDVRREAEKMFNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6L3</accession>
    <name>A0A1E3K6L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035635.1">
        <property type="nucleotide sequence ID" value="XM_019172693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6L3"/>
    <dbReference type="GeneID" id="30189726"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130839" evidence="9">
        <location>
            <begin position="24"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="200"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="638"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="963" mass="102286" checksum="B62EA5E32170B0A8" modified="2017-01-18" version="1">MVAFRAPAALLSFALFAWSLVGAATLEELQADAGSRSHRTVVPNRYIVEFDSSAHYSSAGLKRAATPHEYIYSQLDARSTSYTVHAEYSCQLFFGASLSLTSEADLQVLLNITGVIDFRSVHSLSLPADAIHAENIGWTAQTTFSSSELISEGDESTSTSSSSNASTPTASVNSTAATSAPFSNLPQIGADKVHATGNKGKGIKIGVVDGGVDYTREPLGGCFGSGCKIAGGYDFVGDNYNGSNTPVEDSDPYDNCYSHGTVVSGIIGANENEYGVGVAPEAEIYVYRTFSCDGSTSDDIVMSGLQRAYDENMDIINLSIGEASGWTESMLSVFVSRLVNNGTIVTSSAGNQGQIGAFYSYSPAAGEGVINVGSSDNSIYPAHYATVSTGYGPIPYYNYKAYTDGTLQLYTIDSDEYGCTLPDDVPDLSPYLVIVRRGGCSLSAKAQAIYNAGGTALFVVNDGTSLPIYQNFPLINFAIISLEDGNYLLDQINASTNATVSFSFNPVALPNVWTNNTASYFSEIGPTNDLYLAPDVLAPGSNIVCVTPTALYNWTIGDGTSWSSAFAAGAAALYLADKGTNNITPADVKGAFEISADQLSYSMTDSSLASVAWQGAGRLRVDAAIDATAVITPSEILLNDTANFQRQHVLTVKNPSSSWVTFRFDHEAAGTMLAFQSGLNQSADEPVPQVNTSASVKIFPSTLTLWPGQSLVTTLTFAAPSGLDAAQFPVYSGFIKVTGGATTVRVPYLGVAANMKDMPVLDPTSYYLGINTPVIMNPSFSVQDGTKAYSFNSTDYPSVLYRLAGGTPYISIDLIDSNSTLSFTPDYTTKKRSGQFEHPAEPRRLQSSGGAYPLTKTSSLLSLWCKLTNFQGSGCSSTDNTFGSVDILGNLYSDEWVPRSTDNVDSEGGDYSTFELSSAAFANGTAIPGGTYRFLLRALHIFGDSTEESDYESWVSQPFIVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Z1</accession>
    <name>A0A1E3K6Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CAMK/CAMK1/CAMK1-RCK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035620.1">
        <property type="nucleotide sequence ID" value="XM_019172678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Z1"/>
    <dbReference type="GeneID" id="30189711"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="214"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="716" mass="79629" checksum="9A6D713DBE9D6BBD" modified="2017-01-18" version="1">MSFSAPPTQPSSSSPFLPSPSRALSPVLIPPLSSTDRALTSPPLPISFRHPLHPSPPKPIPIPGSNDTSPVRSRPTRIPSIFRRPSLSTTIDLLARFPLTRHRQSSEILRHGKHAQTASPGAQPTEGKSSRSAKSSQVPTQQPISQQKSRHNDDAQRLAAHHAQTAQQQQQQQQQQQSRVPAASPNYREEAERIVADERAQNDKMPQYPGLEEYRLVEKMGDGAFSNVYKAVDRKSGIKVAVKVVRKYELNQSQHGNKHLNAKFQKRPRVTERANILKEVQIMRGIDHPGVVRLLKFFESDEHYFLVLELMEGGELFHQIVKLTYFSEALSRHVIVQVAEAIRYLHEERGVVHRDIKPENLLFERIPIIPSKNPIHRPYDEEKEDEGEFQLGIGGGEIGRVKIADFGLSKIVWDEQTMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESINVLTEKVARGYYTFLSPWWDDISHSAKDLISHLLCVDPAQRYTIDEFLAHPWIKEAQPPPPPSTRLNVPSNAPMDSPLLASMRAGNREGRSPGVGALKEAFDITYAVHRMEEEGARRRAYNGPGGAGTRGFLHGLNEEEEEGDEAVQVEEARRKHGEVVARQIQEHRGRAAANAASGVKEQPAPAQQYVGRGGANRREAEAALYDGRAGQRDRAEGKSQGGGGFELDLGNATLLGRRGKKVAPSPLAQMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7H9</accession>
    <name>A0A1E3K7H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035731.1">
        <property type="nucleotide sequence ID" value="XM_019172789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7H9"/>
    <dbReference type="GeneID" id="30189826"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="101"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="43720" checksum="7277247CEE8B0BAF" modified="2017-01-18" version="1">MTRGPVLQCIAHTTAEKYDLSALSKALKSLGVRWDEVPEGDPDRAFVIGPWKGRGGAERLIRGKVNKSNPAIQKSPVLEWAENEAHDLRDMGFGYGERGEIWVFNSGSFVTWGLTEEEGRAFLREVIRSGGADVEIARVAPTEYEVEQVDFVVDPTARTHILGNLILLGRPPRLSTFHPSPSLASLLARYTLSLSLSRSSSLSVLEDRLDSHIASVSRLPRALEKYGRQPMPRKEVIQKMGEVMTLRMAVNTSGGGLDDTPEFYWSEPELESYFDSVASEFEIKERVESFNQKLDYAEDVQNTLRALLTESSAHRMEIIIILLISVEVIIVLIREGPELVHKFAEALGLAPAEAEELADKLQDVADRLPPMGILPPKQDRNDHWADGPKRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8K9</accession>
    <name>A0A1E3K8K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_00302</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035428.1">
        <property type="nucleotide sequence ID" value="XM_019172486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189516"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="522"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="991"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1171"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1260"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1300"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO08572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1317" mass="139928" checksum="EA10153AC07AE42F" modified="2017-01-18" version="1">MKLKDISRTATFAWDANSSNTPLLATAAVAGALDENFSNESKLEIWQPDFDNVNHLKLADKAPLGSITVNSRFNRLRWSAPFGSYQLGLLAAGMETGEVSVYDPSKIIAGASADEARILKSEKHAGAVGGLDWNPIQKNLLLTGGINAQIYIFDLNDIAKEPITPGPVSTKLGEITSVQWNPTVARVFAASSSSGFASVWDVKAQKEIVSLQYGGGAAKGMETVGGIAGLQMGKRRGMSDVVWHPENPTRLITSSEDDESPIIMLWDLRNTRAPEKILSGHQKGVLSLSWCKQDADLLLSCGKDNRTLCWNPESGEVIGELPVSNDWTFQTSWCPRNPDLLATASFDGHIGIHSLQTTSEPQPITQQLEEGATPDDIFGALSNQQPSSECSNVLSLKQAPKWLRRPVSATFGFGGLLTTTSNLSGANGKHQSGVVHLRTITTEQAVLDRAEALDKTSGETEKLAEFCSTRASGQDEAWKALQTLFKANSRDELIQLLGFSKEEVAKKVEEAVAKFPNAVTLSKPKEEPVPPVISVEEDGKTPTAEKTESELLDDASVKSEAGVESQKAEEKSESGFFNDEAGPGTPAAAAAADFFSSMASGSLRNPQLDNIVPHKSVTVDSSVAATVGSRPSSVRDEIVNTENTFEIYPEGESDVDKLVTQALVVGDFKSAVDLCLASERFADALLLAVRGGPDLLHSTQNAYFAQQTTSRPFLRVFQSIVTEDLLDIVQNADLSEWKAAFVVLCTFAKDGEFANLAEQLGQRLQFRWRVLSGSDSPEAKEGAQVARQDATLCYLAAQKLEKVISIWLDEMTEEEEAVESTQYTSHAQALQSFIEKVSVFSAATGYVDEDLATPTQSAAAAEAGARTYKLAGLYDRYYEYADLLATQGLVDIAAKYVKKTPVDYKGFGGTGGFDKARERVLWAADEKTTAVSSSIGQSSKAGPSRSAGRYIPAQPAFAASAYGQSNGPYGAPAQQPTYQQAPVASRSVYQPSNAYAPPAQPTQAYENNPYAPAPSSYQTNAQNPSAPNGYGSTPYGVPQQSYNRPQVVPPPPRVGQASGPISASASSPPVVPGSQRRDVPGWNDAPTLVPKRPQSAAKEVKSAAIMSPFPNASPDPLAAAGGGLGGPSGPGVMSPPPMGGARTPVGIAPPPKGARPPSAASKAKIQPPPTAQQQQAQPQPQYSQPPQHQQLYQQPPPQQQQHFARPPPAQAGPPPSTLSRPPPGVRAGPPPGTLAGPPPPGRVLSPLNPARVTSPPNIYGAQQGQQAVYGQQGQSQARPPPPQFARPPSRPATGQEKAVRPPPPGSRLAGPPPPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K912</accession>
    <name>A0A1E3K912_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiprotein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035587.1">
        <property type="nucleotide sequence ID" value="XM_019172645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K912"/>
    <dbReference type="GeneID" id="30189678"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="16898" checksum="443CB87E95414E7D" modified="2017-01-18" version="1">MSTPILQSGWDDKPVIIGQRQQRPTVAKGSALNTAQRNGSILSSESKGAGQSKGAANHQHIAKLDRDDAPKPPEKVSVDVGKAVALGRMAIKNAEGKSMTQKELATSVNAKPQDIADLETGRAVPDQALLGKLERKLNVKLRGAKNLIGTPLHAKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD50</accession>
    <name>A0A1E3HD50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating protein 2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027813.1">
        <property type="nucleotide sequence ID" value="XM_019180212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD50"/>
    <dbReference type="GeneID" id="30197454"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="488" mass="50936" checksum="71720F47B5124F2A" modified="2017-01-18" version="1">MDPTKAQTTATFAHLKSQKSNKQCFDCHAKNPTWSSVTFGIYLCLDCSSVHRNLGVHISFVRSTNLDSWSLQQLRTMKVGGNASLAEFFAKNNGAGLLPPTNGDARTRYSSRQATLYKDELAKRIKEDATRNPQGIHIDGLELTPLASPSKSAADDDFFSSWDKKAETKPATPTTAETSPAAPPSIGKPVLAPVAPAAPAPRTVNSSSFRASSPAARPPSASRLSSSSSTGPKPSKLGASKLGASKLGAKKAGTAIDFEAAQKKALEEEERVKQVALEEKQAEEEAKVQKAKEAEEARKAAEEARVASANASRAAAPANGAGKKTGAATGPVRLGFGQVHGVAAAAPTKTRAVEEDNVRVAREKFGAQKAISSDMYFGRGSYDPTATAEAQSRLRDFQGATAISSNAYFGRDDEESEDGLGGGGGYGGGGGGGGGGEDGDGDALAGIERGVRDMAERLMANPDVQQLGDQIRSGALKLSDYLASFEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HEX0</accession>
    <name>A0A1E3HEX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000058">
        <property type="protein sequence ID" value="ODN74899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027834.1">
        <property type="nucleotide sequence ID" value="XM_019180177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HEX0"/>
    <dbReference type="GeneID" id="30197417"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129125" description="Mitochondrial protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="58815" checksum="768DF3154DB0F4D8" modified="2017-01-18" version="1">MTPRLRLPRPAPLLAASALALCLYAAHSQLKPIHLESLPVVDKPAGRKSKSAPTVFPLYTPVGWGSNRNLILSPDSAQNLVKKPTPLPHLGATPLRDLAIAEEYAAAVDANGDCWLWGKGYDESGKVGKGLRGKSLRTLAPAQSKIFALSKHGNLYLFSPSKAIHSKRRDKPTQSWSSYLFGADPTVDFVELKAEGGMAWGERWKGIDVGKDHLLAVTSKGRTFSLPLTENGNSHRQLGTKAELSVFDNTATRTLPPSKDIRYASLLSPIPSLANIPIAQVAAGERTSFVRTLSNHVLAFGANEAGQIGLGSSYTVEVVPVPVEVVLSKCYPTGTTVECQDIKAGGNTTFYTVQRSFPGRRGTFIDVLSCGSGLQGALGTGAYTSATGLPVKVKTISGLQEYSEKARTFLPIGIYDLAVSKSPAGTHAFAVLDTVREGGGREYGRDLVGWGANIDYQIGISKRSSTPSPIHLPRLGTKLPESIIDPTDLEFVATPQIPLPQDRLQLQQSRTKAYDLEGKLLKRGVRCEQRVAVGWGNTILYERIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF58</accession>
    <name>A0A1E3HF58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027872.1">
        <property type="nucleotide sequence ID" value="XM_019180146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF58"/>
    <dbReference type="GeneID" id="30197386"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129162" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="23725" checksum="667BE31651980AA5" modified="2017-01-18" version="1">MLFGNVLSLLAVAGSVSATGLLGLDLGAKVNVGVGLDLRLGAPSSVRDQCSNKGDFLSEVLGKVFCCSDDNRTDPEDGLTCPKGWSMHKEEKCCIPPTETAPCDCGEGYSFNDKTKKCDKVQGSCPEGTWYHQRSSTCIDNSKPSDPIGDILCPLVGWVLRSDRCEPENEHSPEPSTCPQGHEWNPHSCTCGGGSPSQRALAARHTGILYGANSFKARQLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH10</accession>
    <name>A0A1E3HH10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_08157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027897.1">
        <property type="nucleotide sequence ID" value="XM_019180128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH10"/>
    <dbReference type="GeneID" id="30197368"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11648" checksum="73FBE76B7B30759A" modified="2017-01-18" version="1">MVNKFESYDQYKLLITGSDVVLIDFSATWCGPCKTISPIFESLESKHPHVKFYNVDVDEQPEIASDVGIRVMPTFIAFKDGKKLDNLVGANPQGLVELLATVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ83</accession>
    <name>A0A1E3HJ83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_08077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027950.1">
        <property type="nucleotide sequence ID" value="XM_019180049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ83"/>
    <dbReference type="GeneID" id="30197288"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="32718" checksum="5D5CBAC8AFC822E7" modified="2017-01-18" version="1">MHFSSHQLLRLFLKPKFFLRVRRAGGGTQAPVNENGEIDENFWANAAAERAEGDVDNDEFGSAPAPFESQFFQDDDDGYDGGADMPAIMDYDDEPLITYDENGLPIPVAGGDGGEEDLLAGTQGMELKRARPETVHFAKKAKRVDVKRLKDDIWSGLKTLIPDGPPPTDEDGDTAAVDAELDKDKAEPVQTFNNIITSLRTTYPAQKMSDISTSFCFICLLHLANEEGLKIESARNDGKDSEDVGCMGVLGEDGMPSLEDLTRAGRTEEGERNDRVIGELEALKVYKVRTCYVFSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJN3</accession>
    <name>A0A1E3HJN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_08161</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027901.1">
        <property type="nucleotide sequence ID" value="XM_019180132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJN3"/>
    <dbReference type="GeneID" id="30197372"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN75631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="395" mass="43426" checksum="CEFE543BBB7DF75C" modified="2017-01-18" version="1">MAATAPQSAGTSNETTPRQPLWLRCEKKPFEHRSALTPTTAKKLIENNFDIFVERDPQRIFDDQEFEDVGCKLVAHNTWPSAPVDVPIIGLKELPESTDPLPHTHIQFAHCYKHQAGWNDVLRRFAQGSGTLYDLEFLEDPVTHRRVAAFGFHAGFAGAAAGALAFAAQQKEGGEGVLRGLEPYKNEGDMVREVGEALEGTREGKKGVRVLVIGALGRCGSGAVDLFRKAGVAEENIVKWDMAETAKGGPFQEILDVDIFVNCIYLSQPIPKFITSEFIAQAGEGRRLGVVVDVSCDTTNPHNPIPIYSINTTFPQPTVEVDTKGVGKRATVISIDHLPTLLPREASEQFAGDLLPSLLKLPQRKTAEVWTGAERLFREKMEEARAFDEEQGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLT0</accession>
    <name>A0A1E3HLT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_08085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027958.1">
        <property type="nucleotide sequence ID" value="XM_019180057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLT0"/>
    <dbReference type="GeneID" id="30197296"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129265" evidence="8">
        <location>
            <begin position="20"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="10">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="9">
        <location>
            <begin position="538"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="835" mass="91223" checksum="F29A16E49B11A5CF" modified="2017-01-18" version="1">MPPSNWISLWMAAASIVVAWDVAYCLCRPRSFAGGDLAWIWKPDNNYGEIDYIYGWKAYNEGDGFTAAQATLNLLEVTLAVIYLYLRHSSPRHSSAPYHSSALLVGFASALMTWSKTVLYILQEYLCGWCNVGHNDRWTFWCMWVIPNCSWIVFPGLITLALGSHILSALQRDSIAQHPSAPSPSLLVPTPAGLTKAGLTKKGKPALTQRQDPNPTHTLPLTFHPHNLPTLIIGSNKLAASRATTFLSAGALVHITSPLPLVDCAKEVQVLVEGGKVEYERKELGTEREWREYLEEKDVALACVTSTLISPSTPSPSSPSPVSQIHNACLSLHIPLNTSDSPNLSTYTFPSTHRFPSHHPSTPSALTISVSSGGLGCRMSGRIRREVVSSLGQEVGRAVDNVGRLREKAKAFSKRDLLPLDLPSLENQEGPLNSPVPQIPTRSLSPSSSIHSSSSAPFPKALLSESEQQLRRMRWVYQMSEYYSFEHLARMSEDEMDKALEIWGEKDYGGELPHHLPSDRLSQSQEGEEEKPVKKGRILLVGSGPGHPSLLTLSAHHALTTSTLILSDKLVPSQILALIPPSVKVHVAKKFPGNAEGAQNEMMQLALEGALRGETVVRLKQGDPFVYGRGGEEVLFFRKHGFESTVIPGISSALAAPLMMNIPVTQRGVAESLILCTGVGRQGRAVQLPGYVRSRTLVLLMGVARIQQIVDTLLSPDSPGRDGAAFPPHLPIAIIERASSPDQRLTLSTLSRIAPSLAELDERPPGMIVVGWAALALEGKGRVDILDMPEEGEEAMVREWLAEEGREEEGWKSGEGWKVREGLNEDWKGILSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLU0</accession>
    <name>A0A1E3HLU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028001.1">
        <property type="nucleotide sequence ID" value="XM_019180002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLU0"/>
    <dbReference type="GeneID" id="30197240"/>
    <dbReference type="OrthoDB" id="10597259at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN77294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="203" mass="23495" checksum="1BDA15EC41A8AF8B" modified="2017-01-18" version="1">MSQQDSQEEAHYVYPDPSTLDEGNPLGQHPYYRTLQVQEEDDEEAYEGEYRYDDLEEYQYDNEAEQFQDHTGIQNSEGYSTSQQDQLTTTTSSHTNRSKPGTACPCPVEHTSFLSRVEGKKTWIPSQGPQCPRTIHPESPYSLCYTCRERSSHTQAHVEKLTEAGEDTDDRLCQIFKAYNESDKTVRWLKYLNNESRENDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HMB7</accession>
    <name>A0A1E3HMB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adrenodoxin-type ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028002.1">
        <property type="nucleotide sequence ID" value="XM_019180003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HMB7"/>
    <dbReference type="GeneID" id="30197241"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN77295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16088" checksum="CAA593C570FC3EBC" modified="2017-01-18" version="1">MPRSSPLLHQLRTFATSLRPIPSKRLHYVLPRPAAVSEMGLRFGGKRGISSTPPRYHGDLVRPEPGTGIKLIFRDSNGADIKTVEGNEGDDILSLAHEYDVDLEGACEGSVACSTCHVVIDPASFDLLPEADDEENDMLDLAFGLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HMD7</accession>
    <name>A0A1E3HMD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Siderophore iron transporter MirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028022.1">
        <property type="nucleotide sequence ID" value="XM_019180023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HMD7"/>
    <dbReference type="GeneID" id="30197261"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="615" mass="67309" checksum="53CE003E45F633F7" modified="2017-01-18" version="1">MGFLTNFITKKEATVAVTSTAEPGTVGNVNVLTDKDEIPLEDTASADDKKALGLEEGNGEPDFEGSVVNEDKIDEDAQPGVKTAQATTLSWSRTSLVILYVSMFLLYFVNAFQSSITGNLTAYVTSGFSAHSLIPVISIVSNVMSAATYMPLAKALNLWDRVWGFIIMAGLATIGLILSATCNNIAVYCASQVFYGIGFVGMIFSIDVITADTSRLRDRGLAYALTSSPYIITAFAGSAASEHFYDSNWRWAFGCFAIVLPVVATPLIWVLWHNKRKAKAAGMIQRVSSGRTPWQSAKYYFIEFDVIGVFLIAAGLVLFLLPFSIASSEADEWRSASVIVLLVFGVLCLAGFVVSQRWLSPKPFVPWRLLTNRSVIGACMLDFFYQIAYYCWYSYFTSYLQVVFNTSISVAGYVSSIFDVVSGVWLIIVGLLIRKTGYHRWLLMISVPLFILGEGLMIHFRKPGGHFGYIIMCQIFIAFGGGTITICEQLAVLAAASHNDAAAVLALLGLFGYTGGAVGNSISGAIWTHTFPEALQKYLPTDALADWEEIYEDLEVQLGYEWGSETRTAIIDAYADAQTRMLIAGTVSMAIAWIFVFVIKNQKVSALKQTKGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HS26</accession>
    <name>A0A1E3HS26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028126.1">
        <property type="nucleotide sequence ID" value="XM_019179890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HS26"/>
    <dbReference type="GeneID" id="30197120"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="134" mass="15012" checksum="819A0E138D037E45" modified="2017-01-18" version="1">MWNTSNQSDAGGEWAGKAKEYTVNTIYYSKGNVHFNTSDNVLFPFDLDRLSKVSSFFRDLDDIPQPSGKKIGAHIPGQTIIDRLNNELSLNERADIDIPTHMDAIIIFPECDAKALQPWLNLVSFGGAYFTDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5F7</accession>
    <name>A0A1E3I5F7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028379.1">
        <property type="nucleotide sequence ID" value="XM_019179611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5F7"/>
    <dbReference type="GeneID" id="30196832"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="315" mass="35542" checksum="C2C4B8A6BCF3C273" modified="2017-01-18" version="1">MTQHDSPPVASLESGGPAIAPEVEEPPHEFVYEVVQGFFVQNGPEPKHIEFEDLLGKSFGLIDESPDRWHNLKASIEVLQNEAPAGVIYKVLFLGRHGQGFHNVAESKYGTEAWEAKWALLNGNGELTWGPDPFLTPLGVSQAQAVNDTWRKEAPLGAPVKSGEMRWYCSPMTRTGETMETSWKDVLEEGERIEVWEDFREIYGVHTCDKRSTKSIIKERFPAFTIEDGLTEEDELWKPDDRETDEHMQFRARRAMDRLFGRRGAGKTYISITGHSAIFRNLLAVLNHQPYPLATGEMIPVVVKATHTSIERPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7V9</accession>
    <name>A0A1E3I7V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial metalloendopeptidase OMA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028381.1">
        <property type="nucleotide sequence ID" value="XM_019179613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7V9"/>
    <dbReference type="GeneID" id="30196834"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="215"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="402" mass="43831" checksum="397DFC22B3D5CDCC" modified="2017-01-18" version="1">MFSRISKNTLKDVSIHLPAPTPRFPVRPPPLSRPFHTTPRLAARYERFDERPSFGNVGGGSSGGGAGGGGPRGPNLWTYIKRRVGGERAVWVYGIGIGAGGVYYVAHLERVPETNRLRFIDVDEAQETELGRQTQLQTLSEYSTAVLPANHPITKRVRKIATRIIESSNLGRVKSGGEMGAVEGKVPSFGGGVEMKDIFLGGSGDGSHSIKEGKETEWEVYVIDDKKTKNAFVLPGGKIFVFTGILPVSANDDGLATVLGHEVAHQVARHPAERMSSMKVLFALGFLLETLGLDVGVSRLLLTFMLQLPNSRKNESEADFIGLRLMARACFNPSESTHMWERMSQSEGGGKGLNVDFLSTHPANAKRIKQLTQWLPEVSPASLPIPNSSHGKDVKEKEGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA22</accession>
    <name>A0A1E3IA22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Chromatin Elongation factor SPT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028427.1">
        <property type="nucleotide sequence ID" value="XM_019179570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA22"/>
    <dbReference type="GeneID" id="30196790"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="13">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="909" mass="98344" checksum="BF63CEF0414C8CC0" modified="2017-01-18" version="1">MSDTKITSPPTGSPVEDRAAGKKRARIVDPDETDEEDYDNAPEENNGGKGPKEEEEEEEEPSRNRSGDDDKDDEEDEEVEEDEVDEGRGRPRKRPKKNSKFRFLDVEAEVDDEDEEEDEDNDFGDVAEFIDEAHDDAVARDDQQHRRLDRVFKRNEDEDVHDIVQRLKERHAGTGMARYNGDSDTVPQRLLIPGVNDPNLWKVIVKAGREHTICASIFRKVFAQQYFANPIDVISVFCRDSISGMIFIEARQSAAVSAAVNGIVGIFMSRGVSLVPIEEMAPLLKMKKKDVNLTPGMWVRMKRGRHAGDLAQVVDVDQITSGVVGIKFIPRIDLTPKDKRKERMAAGKPGGVRPPSRLFAYDDVRKIYGRQSVRQGPQGSYQFENDEFLDGFCIKDVKIPTVATEDVNPSLEEISRFTGDDETAAKFDLSAIADANRNLSTSLLFPGDKIEVYEGEQTGLYGIAETVTPDVIAIKAEGGEVHGQIIEVPARSVRKRFDVGEHVKVLGGKHVEASGMVVEVKGDIITLMSDQGEQEIKVFSKDLRKAADTSNLTATQGIYDVHDMVMLDSTTAAVVTKVEGGFLRVIDQNGAPQSVSPEQVTLRRDNKRFAVATDSQGNEMKVGDNMKETEGELRQGEVINIFRSLFVFLYNREYTDNHGVFVARAGSLISVTPKSAVNDLGKINPALNQQLLYGGASLMPAPAVNANRNRLINTLVVVTKGTNKGLIGVIKDVQGETARVELKTSNKTSSIPLILLKRKDAKTGTTFPLESGGSFAAPGGFGAFHNNPYNVGPYGGQTAMHPSMGGAIPGLMGGKTPGARFGQTPNPYAAGVDNGKTPNPYTSAASVGKTSAAAYAAGGKTPAWGANGGKTPAYGAANGGKTPAWGGAGDMGGKTPNPYAMGPGGGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDC3</accession>
    <name>A0A1E3IDC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028780.1">
        <property type="nucleotide sequence ID" value="XM_019179299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDC3"/>
    <dbReference type="GeneID" id="30196503"/>
    <dbReference type="OrthoDB" id="10386170at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="127" mass="13634" checksum="A826AE67F90A37A0" modified="2017-01-18" version="1">MTILWASHHHQLPAKPSGVSKYLTVPSSPAEKQQPSLSQSSPKADEISTSTCISRSSSSDSLSSTASTTSLAYQLPPFPMTFPGFDVVDLFKLVQRGIFARKGGLGDRSQEVKEGEEIEMMDTGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFS5</accession>
    <name>A0A1E3IFS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028938.1">
        <property type="nucleotide sequence ID" value="XM_019179020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFS5"/>
    <dbReference type="GeneID" id="30196213"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="36995" checksum="5622FA0C8AD643D8" modified="2017-01-18" version="1">MSELTPAQSRLAALNRLKAKQKLASAPSSSASAPGQGVQYVNKRQPANVPTSARNMVEHQARAGDKHGEKGNGKGEEMPMRRDPGLGKYFEYDLSKMKNSRGGFLTEEDVTGDRIKSLKELAAEKERELRQIREGEEPAIVPGRSPKCADCGSLEIDHVFEKTFGVRVCRKCQKEKPEKYSLLTKTECKEDYLLTDPELRDEDLIPHLLRPNPYASNYSNMMLFMRAQVEKVAYDKWGGDEGLDKEWERREEFKKRKREEKFEAGLRDLRKRTRNNLYQRKQDAQHVHEYEDVEQVYDEEEGSTKVVQRCFGCGAEQEMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IG09</accession>
    <name>A0A1E3IG09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028848.1">
        <property type="nucleotide sequence ID" value="XM_019179231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196433"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1660"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN86856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1970" mass="215654" checksum="4546061DFC58DD6D" modified="2017-01-18" version="1">MSHQNGFPYFSAGPGYVQQPSQPHPQPRPQPQPQAAEAEDPGTMLNVYPFMTYAPTARVAQHLSSHSSLPQPSPTAHQVYPHYTQSFGRIEQPLTPGDWEMRQAADMRVRDVLEAQRQHGGSYGYSNAPLPSMRQFNYNQVPPTPVPDVNPYGGYSQPLSTSYPFVPAYMPPPTPVSSAGTRHTHPATPDSMTGDSPASVPSGKEYFEGFVNNTLARHVSQERPAPARSQNGTPSNLPRHVISQEELRGYDQYRSSPEIRPAPYSQPQNGQTPPQYPPQMSYSQPQPLHQAPGRVPFPSQPIFQHGVDKSATLPLARGKSPAKRPSISSMAMRSPHPSSSVTSTPTHERVMSSPYPSSSPDPLGMPTPSPSKKPRKNRTFSPSLARSGNLANDNAMGIDSLSMREKSVSVASNASGEEQKQKIMLRLPMHLATPQRSPAPEEGQDEDAEGDEEEDGVDWGDDGVRDAEGDWQMEEGNSSGTVYGGAAGAQIQMSGKTGERDTRNSWQKLQTLLEDISEENDSFTANPTLEDLQSSDIKFFGHVSRDGSQALLSQKTMSKVIRYVLRVQSGRKRPGQEANGPERVWDIALVSTLLRLLERSIRDVENIVVFPDDRKAAVAIEEKAAKKKGKGKAGSASPAKPEDAEVKAEIPLADIQACEDKLMRVKRSVAAAECSLLLLDSEGISKQLYSEELLSTCVKTVKDHLEQVVLPVIQGLAGDKIGSSYLARLVEQEYNAVAPEPKLPTSLSSHFHHHTLSAIAQSICITLPRLTSLISRDDFHFSEGLLIQTVYLAKCPLFVVDPVVGKKKGDKDGMAVVKSMRMEGLSLLRGVFARYEEQRQWIIEEVLSSLVGQAGQSHDQALFQLSNGKSIHAVSALLLQLIQASAYGAVAQVKKVHTASTEMEVLDRQETEKVDTVAEESRICGETIESALKSATMVAGYILSKATTTRATKTSLDTDYKVILSLFINDLLAVLYRPEWPAASLYLSVFSKIMINALDEKKTGTEATAAKGVALDYLADIVARLKNLSIEMLGEIKVATIDEVISEASVTGLTRLIKAQGSIRAFLTSAARDDGSFACSLDMASIVWAQELQAGVKKTASVLEKLAVEKDDETKALGDNLRTIGSMLSDTLRGVWLSDDSLFEVNDPKQGEQAVQASIAVSRGRSLQGAIDPIIHTLLSTMSNTIIGLRTKALRGISSIVVVDPDVLRLPQIRHALEERLSDASPGVRDAAVELVGKYLIQKPELVPQYYHQIASRVMDTGLSVRKRVIKILKGIFATMENRKMQVDICCRMIALVDDKDPGIKSLSTNTLVDMLFSGEGGDAARLFVDILSNYRGTYEVMEKALDEVSKECESVGQKGRFGTTIDDLINRLIDATEENDFDSLSHIRAIWLLAESDPSQIDMQKANVLLGYLRPPANADDQATNELLLKVFQRSIPAMPRTASTFANSLTKTLMPMISKPAGGFTALREIIGCFCAVTNHLTKDWPKAINVLRACEAKIRSVRPGVKNGSVTTLNPAIAMMLYITALLVEGCNLDEIAKQDDAIDAQVRRISSQPLAVYFFELYLDFASMSTPHSAPTICLGALFRAYPSLLQLSETTDWMKKTFESNDMDGQCRLLGVLHQFLSSEVKKRASAGVANKDVSLLIGNSKELQDSDYSTVIVQNNIEQIFKCARSQHVPTQNAALDVLTFVVNQGLYSPVHTVPILVTLETAEDPIIAERALALHSTLHDKHANLIHVLFMDSARASYQYQRGITAEPSGHRNGIALLSSWYEMLSEKRTWRHDFLKALCRAFDSDLDAEVDIGFVLYIAENLATMDYKLQEEPMTVVQALSRIVSTCSHLATLMEEAHINAPPEESIDGQAINLGKLSGETIKAGRLADASIIVGLALMLKNHLVSLYHLQEDKCAAHVPGKKSATGDKPSQRRGIQVLDLDRMSMVRGIATVGDFKQQQTAFLELLKEDGTLSENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II32</accession>
    <name>A0A1E3II32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_06844</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029153.1">
        <property type="nucleotide sequence ID" value="XM_019178876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3II32"/>
    <dbReference type="GeneID" id="30196055"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="380"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="704"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="970"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="817"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="857"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN88085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123932" checksum="C6078FE37D8946A5" modified="2017-01-18" version="1">MARGYHPDPPPPQDDSKLPPPMTLERPPECVNRNSTPAFYVVVSALESIRKQKQHDKHQTLVRLFALWRQNVGNDLYPLIRLLIPDKDRERPNYNLKEAALANAYIEALGLEKHSEAGDSMIHWKQPKLTGGRQDSSGDFARVCFKVIEPRCVVENGQWSVEAINHTLDELTKSKADKKDKSRILRQVNTYCTALEQEWLIRIILKDLKISIREKGILQAFHPDAMQLYDKCSDLKRVCWELWDPERRLNTNDIQLELFNPFRPQLCAMAKGHTHDSIAKLVGAPHKEFIMEEKLDGERIQLHMRGNGAQWFYCSRKAKDYTYLYGAHPGQGSMTKYISDIFQDQVRNVILDGEMMVWDPMLGKYLAFGTLKTAASMNNTDPNEPRPCFKVFDILYLNDNCLIDKRLSERKRLLRGGRIFKDIEKYTGRFELVEEKVGKTGKDITSYLERIMETRGEGIVVKKPDSKYSTGSRDVDWVKVKPEYSDQMGETFDLLVLGGWWGKGGRSGKVSSLLCGLREQEEIGEDGERPTFQTFCSIGTGLRYSDYTWTMDTRGQYFKPFDRKNIPPWMKMGSIGLDDKPDVYIEPEHSFVIKVKASEIVPAAGGYGIGYTLRFPRATHVFGGDLDKFRESREEKVEHRDMWHCVSSYSVNVRYGADISCLMNGPVKKYQESQGQNKKRKVTRPKKNPFMVSAMGQVLSQDRVKGDLFDGVTFFIAKGTPAHPKAELEALVHEHGGLYSQGQLPNLSAKVISPDEKSPSVRAQIRKGVDVIKPEWLFQCIKRDYILPLIKEFLVHASAESKASRYYNRTLEHLQAISDDEEEEEEEEENVAEPLNEVAEEEEDDAAREMKYKKKKADREEREEQEQREKRKTAEQRKLEADWGMRDVPKPGSDSSDEEDNRGKYDEDEDTEDEYGGRELDGDEDDKAADSHDSDGEENGQDEFRTMPVGPQDVQGVATMGDESDAMKYDEEKIFRHLAFYLDTSENAELNGLAPSSPTTSIKERYVARVEKLLQDGGGRITTDLHDPKLTHIVMDEDDNGRYEELTKKTSKPKMKHIVLPSWVEDCASEETLLHEDIHKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3III2</accession>
    <name>A0A1E3III2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029212.1">
        <property type="nucleotide sequence ID" value="XM_019178729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3III2"/>
    <dbReference type="GeneID" id="30195886"/>
    <dbReference type="OrthoDB" id="2577488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="39020" checksum="1F69428EA8CDEFD7" modified="2017-01-18" version="1">MGEHFMPKFVVRGTCTPLDVAAVHRVASGISDHRRVNSFILALSPLNIANTCSSIIAMQRPDAPLHRLPLPPELALEIFDTYTAITLPGTPEFLTLLTLSRYHYALNIRRLYRDVRLKESMADRFVDMWRKWSSQAYQLLTAEPSMGHVMDEDEMVRNLLCPIKCNSTDFNIKTLTFQNAICFTKISDLFNSPGSYWWNLWDRHPSLPHSNRLLHGAKTVVFEEQTLGGGEVRMGSYAMYARRNVYTHYGAERLVIVMPSRPFHCISPLALNWLAGIGKRLPDVKNVTLEYMTAVVGEGATRFKKRKHRMEQIDQVESKIKSWDNSSLQVSVVDPSESYDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIM3</accession>
    <name>A0A1E3IIM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029253.1">
        <property type="nucleotide sequence ID" value="XM_019178770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIM3"/>
    <dbReference type="GeneID" id="30195928"/>
    <dbReference type="OrthoDB" id="2577065at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19127" checksum="16FBF7B38D7666FF" modified="2017-01-18" version="1">MSAQQPTVIYITPTEAPPEDRPDRSASLIVPDAHNTDYCHYPWERVSFRAVSRDGTVYERDSHFVFKDPIDPSIDTDFPGSGVREHYAKLYLANGPDDVTFTLLSRYVPDPYRRTWTVEHFNATQDQRLERRDDRLCSCTEPDCVLQSVPTELADRLIEAIDNEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJG7</accession>
    <name>A0A1E3IJG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029312.1">
        <property type="nucleotide sequence ID" value="XM_019178611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJG7"/>
    <dbReference type="GeneID" id="30195768"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="34476" checksum="D9CCDF22C4074577" modified="2017-01-18" version="1">MPNHLPTLIVTPHGQPDHVLYTYLHTEENRVNYLLTPSPQGDLCVAKLFPPPRPGQPSSTATLPTMSNKQPPNSVRCEASRDLRWTIENTGVMSPIYKIVNQDDTPLYQISKPNPHAEFWTMFYFKYAGHQIPPKRIEFGKISKNPPEKGGGTRLSITGKSEDEKQVWQTLGVGNEDCVEWVVCCACLNLLDDEILRAAEKRANPNSAPSHSPASTAPASSPASTTGRPNLASLQRVPPSSGPRSAPGAGIASSAPLPGQHPAMNLAQTYRQAPPPQQSRGPPMRPHMGQQQMSGMGQQRAPQGYAPMQGQGQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK69</accession>
    <name>A0A1E3IK69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029169.1">
        <property type="nucleotide sequence ID" value="XM_019178892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK69"/>
    <dbReference type="GeneID" id="30196075"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="341"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="440"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="902"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129790" checksum="1F7AF14ADFF4CE4D" modified="2017-01-18" version="1">MDDTAPLADDCDPTYTHFAHRAQFLALLDRFLALDLCHESGESEEEAEVGLVDEMGEILDYYLPLPGLLDPSLHEVVPPLMTLLEKSLRILDGQIDHDTVTVNGKRLERVGRVVNWVVKVRGWKAVVPYFPSSIPNLPLIISILSPHSSSTQHHSLLSSSSAWELRSVLLLWFALLLTVPFNLSALSDGDDPVDSKPYGLDLSSATILFTSRTSDLAQRVTLIAAPLLHKPGREGAYAALLLARLFSRTDGVQGLKGFFAYALRELQESDREEEVHLVSSLFHLIALLPSMLPQGHLEQVETFLAQMFDHLRGGRTVVESGLVRKLAVKAKGRLWVTKIGRKREEGDEDDLPEGLEEVLDEFMGGLSDKDTIVRYSSAKYLSRLSNLLPPDLSDQIVGATIALFSGTEDEPAIFSSCGGIIDPGGSPHTGGTFALSGGIETTRGESRWHGVCLALGEMARRGLVHSEQVGEAVEWVLRGLTFDIRRASHSIGTNVRDAAAYVLWSLSRTCAPALLQPCSSQISTALVNTACFDREVGVRRAASAAFQEGVGRLGQGVYPEGIDVLGKMDFWGVSVRRRAFGVAAPAVGIHKVYREYMIDHLHNVTLRHWDVAMRTIGAEALKSLVELDISRLDQSLDREIKELSGLDPINVHGALSALSSLSSLFPASDSRSHKIFTSLSSIRTPTFLSTQAPDILISLYSLLTTILSPEVLEGEGGKGREKLGKWLDMAGRRREVGVHERGATVWGVLSRMGESTRDVEKLMADLKSSRATIRQYATLSLGHIQYPSSTSPLASTTQKAVKALLGLLKEDQRLKVDVESRKWAVRSLGDIGAQRRNGNVVVKYDTFHEIISALITSLQDYSTDQRGDVGSWVRIASLNSLGLVLSSLAPQDSLLTEELRDRALAGILKQAMEKLESCRGAAALALARLRQAGWHWLADSSFHSPADMNVEKLVEGGFRYVDQREWFASGVGLLGEEKWRRDVLEGLVLTVGSQVGSLASTAFAPLLDYLTAHPATMVPTLSTLSSILSTDFTRNRVFIPTLQTFWKLISTPGIWALVANDEKEVVTVVHAVLALATKGSASIKSIERISVAMRLVIASLSGPKLVRSKAVGLLSLYLNHRFPRIRAITSEELYLALSQAEDGEEMDEELEEILLETEWVATTAAEDGVDLGERAEKVVELLRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM59</accession>
    <name>A0A1E3IM59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029581.1">
        <property type="nucleotide sequence ID" value="XM_019178425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM59"/>
    <dbReference type="GeneID" id="30195574"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129905" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="22"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="8">
        <location>
            <begin position="414"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="569" mass="63685" checksum="90C734DE9E33A0CA" modified="2017-01-18" version="1">MNDRGTLALLSLLLLAPFSLAAEEQKVLVPSQIRGLNPSLYDKYEPTTSGLFHCLDGSRTIPSAAINDDYCDCPDGSDEPGTAACSVGFFWCKNEGHIPGNVLKSRVNDGLCEPDCCDGSDEWATGACPNRCEEVGKEYREAKSKVDKLRKTGSKIRNTYIKWAQGEKQRLQEELDEKRKAISAKEVEVTIARAALDKASAQSHEDLERKKQSPVYHSLLSHRSALTKLRTKTKTLETEIEALHSLLREMAKGYNPNYQDMAVKAAVVGYEELTGIKYREGESEEGEVKKEEKPEETQEEITEKELEDLDKIDLDGLLLSDTTGAAAEGDEDEEDGLLWKIDEYIPDNFYDSWQTIRDLVIEWSVRLGLAGKPKNKGNGVDGPQVAAAREKHRLLETELVKLQNGIRSNEDTLKNMELHYGVEAEWKKLDGTCVEQVIGDYTYELCFFGKATQKSNKDGSSNLLGQVFRASRKTQLTRHSKFDQWNVAASEGTLPYYSQQLYKNGAKCWNGPNRSVAVVLSCGTSNALLSVAEPEKCEYRFKISSPALCWPEQQPVVEREVKQESKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS1</accession>
    <name>A0A1E3INS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029782.1">
        <property type="nucleotide sequence ID" value="XM_019178344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS1"/>
    <dbReference type="GeneID" id="30195490"/>
    <dbReference type="OrthoDB" id="10301774at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126930" checksum="9E9CD1900B46A4BA" modified="2017-01-18" version="1">MPTFHLFSKETKSDDAPGDSGGHCPAPAPASHPLTRTFAGTIYHKGYSEGAAHTHRSTLATTPTPFDRLAAFASDHPLLTATMVLSVAGLGLAAKPAVFRRGHISTKPQTPGLARLFSSPQGAPSLPAAARFRDLHIREPPPTVPAVVKVLENAQHDLGETQAKDRKETRETEEAREARIAEVESRLEREGALEGAKTRGVTDISPDKSLHEAAEEYLGKTTGGILDHMNKMVSADDFVFPIERNTSTSINIHRGDSGILYANKSFTIISPHYHNITDASSKARKNGQTHVGFYGLVRVYTPIPEQDISLQTRNGTTFKAHLLYSTSAERSLVRISLDGYCLATHSAHLGDYPKLGHAVIGRLPDVSRECLKVQPGEQAGIDAAYERHFDQLQERLVSSAKLRFEGKEKKRKESGEEVELFTFPDVSTQPHPTYIARGDSGILYDKTRAIEIIRPDDDDKFVYRSTDGPIFVPGLVKVYKRVPDERPSTKEIQSGKTFKVRLRYEDVHRINGPSYIAIDGHVLALMEDNEQFVVERCSGFLTDREKDILEIKPGEVEELEAVCRNYLDENAWSIEDWEEEVYDDIRAERASEILAKETKAAPTFFTTQGYVFPSVTPRTTPVPAIPKGTSGIRYDSNKAFEIIHRYNPDSLRTHDFGFGPSFEDGIVVVYNKWNSGDAIERLEQGVMLKARLRYDHDSLDSPSYIAVDGFVFSTRRDASSNDLAIERCEEVIPEETRLALNPNAEERAAMSEIRENVIQKQKTEIESSTAKEERDFKAREAKMLSNLKFPTTPLMPASHITKSPAGIRYTKNTAAVIISPTWDLLPCHQKGYVTDTEYVVPALVVVVPPPANIHVDFIDQLEKGVLVKTVVQYKNDVAVRIAMDGCFFSLRFAGGDDVLHQFLGGLGSDVAELLEIQEWERPQIDKSIKEYYERLNEVDDPISFDSDDALPSPTFSTSSTNTSLAIPPPLGNVSSLKEWDFTSATLVNGRPAWVAKAYEERPEVFVGSAPSISEDELMDVIFDRNGHGLEFFIERSVEEGGWTLDTPPFGLKDAENEWMEERGVGIGLKGWERYHRWIVRVRGAAIATHGAAFNGETRSFTCAVRNNFIQAKALYLPGGGDIGLKLGKSGEYTIHQDPQARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPA4</accession>
    <name>A0A1E3IPA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029787.1">
        <property type="nucleotide sequence ID" value="XM_019178349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPA4"/>
    <dbReference type="GeneID" id="30195495"/>
    <dbReference type="OrthoDB" id="10315324at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="185" mass="20894" checksum="88E52E2EF3C70ADB" modified="2017-01-18" version="1">MASSNAYNEEVNSTDSNPRLNDCFTFEFDNANGDLEAVEWSVHANPNNTETGYDVRGRNFTSGNTWTYGQQTIESLEWQYEEGCQRLYSALTGRAPRLPKQSEFIIPERTADGRRSPSAGTMVAIWKTREAEGERPTECALLISHYEAFEGFEKMTIDQVRMCATLDDDVGEAAKALLEEREREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQA3</accession>
    <name>A0A1E3IQA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029885.1">
        <property type="nucleotide sequence ID" value="XM_019178166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQA3"/>
    <dbReference type="GeneID" id="30195312"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="778"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113346" checksum="206949BAC818D74F" modified="2017-01-18" version="1">MATSMRGLTQYISDLRACRVRELEEKRINREMAHIRQKFKDGNLDGYQKKKYLAKVVFTYILGYKVDVGHMEAINLISSQKYSEKQIGYLALTLLMHEGSDLARLVINSLRKDLEDHNEVYNCLALHAIATLGGKEMAETLAENVYRSMISATSSTFVKKKAALTLLRLYRKHPSVMPTTEWAERIVSMLGDRDPGVVLTVTALVTAMAQSELEAFSGCYQKSVDMLDKIVFESHYPPEYIYYKVPNPWLQVKLLRLLQYYPPSDNPQVTDIVNGIIQAIIDSSQETPRNVQHNNAQNAVLFEAINLAIHIEPSSQVVHNASILLGRFILAKETNVRYLGLDAMAHLAATSNSLEAVKKHQNVIIQGLKDRDISVRRRALDLLYSMCDTSNAKVVVGELVRYLHVADYNLREDMVLKIAILTERFASEYEWYVDTILQLISAAGDHVGAEVWYRVVQLVVNNEGVQDYAVRAVYKHLQATACHENMIRVGGYILGEFGHLIANDPGCSPVEQFQALHSKVNLCTAPTRALLLTTYVKWVNLFPEIKEHLINVFERYTHVLDAELQQRACEYLALARRSEDDDLLATICDEMPVFPERESALVSRLHSRGEKAQDKRTWVIGGREENSQRELQRFKTFRKGTGDSGGVLANGSPVAAAAVPAPVQAATPEPRQPPPRSSSVQTDTLMGPSSGPTEDIMSSLADLDLTGNNVQDQPLLPDATGYASDLATLSINPTGMPLQPDVTGVNGGKMVHNATLGGVNPALLAPLTVADGLEKWLERQTYANEGILFEDSTLQIGVKAEYHGHLGRLALFFGNKAGSPLTSFHALIDNPSPSALNIHFHDTPVAEVKAKAQIQEMIHVECKDVFAREGGTPLLRLSYFVGEDRKILVLRLPVFLSKFVEGVQLESAPFFERWKIIGGPPREAQKIFPIKVSSTGAVDAARNARIISGNRLSVLADIDPKPDNIVFAGVLHTSGAGKVGILGRVEPNKDAKLCRLTVRSTNELVSAEILALTSKPLDVDVAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQF3</accession>
    <name>A0A1E3IQF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029935.1">
        <property type="nucleotide sequence ID" value="XM_019178216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQF3"/>
    <dbReference type="GeneID" id="30195362"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="377"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135587" checksum="F8BFE19D37CB9880" modified="2017-01-18" version="1">MTSTRYGINAYPSKYNDPPFQKELLNNYGQRSQPRPGRAPANAPDTPSEYDRFAFWPDAIAMGSLQGRQFTQVFGAACIKGQDERGLGRSFISFDLKREILVIKATTKLDPRILPPALNPLSAELSFNDITHQGIHITKKPLSDAIGNPDLLEVTVTVSCRRPPKFFTDFDPGDDVPQYLQGTRYSLYRRRATAMDFTTSGVREREAGSIPAIPEGPCAYPTFWNTYRWVFRMDRKKYDRITACANKIRALAQADPEMDLMSLASERARWSVRVLTGAEFKQLYTPPDMSKLAFSTRTLLEGLIGHGVLKPANTSELIVTLRKVSTSTAFHNRILEALFSQEIIKDIKALVPKLAAFLRRRPPCIQPHLVLIRTVLVTPTRVLVGPPQYEPSNSVTRRYSDKLDGIIRVQFTDEEDRLYVVDYLKDADNIDPAVGLMARIRRALQYGLIIGGQTFYPVASSASQQKEHSMWFIDTRVIDGLSLRNWMGTVHETVVAKHAARMGLPFSTSRIVNMKINIAGELPDIKRNGRIFTDGVGIAGKLVLHQAALALGERQGLNSNPSTIQFRLGGAKGVLANWPQLVGDEEIRLRPSLIKFTSDLDDLNVIRIAKYQVAFLNRQFISIMCANGVPHDLIIEIFQDAVADIKGFRDRVKQGRLSKADQQLVELCNDFPFMQLVRAGFNTNPLLLDVAAILECRALQDLKWRARVKLSNGVYLIGISDETGILKEGEVFCQFQENDETPAKVVVNEVLICRAPALHPGDVRRVRAVDVPELRHLKNVIVFSTQGERDLPSMLGGGDLDGDDYTLIWDQRFVQTLKVYDPMEYTAPDPISVEEVSQKHLNENFVQYVLNDVLGQVDNCHLALSDYFTPFDPRCLHLSEVHSVICSVDFAKTGQAAMLDPSLRPQEWPDFMDKDDAKITYESKGILGKIFRLVQRDPHFSPSDLERMGYPSDPRISRYPLHDSLLERLKPLKASYERDLQYDMRRYRVYEPEIPTGIAIRNKRRKRVRDQNLNEPLREAYSILVNNVRDAAAKILRDFSFKTTLTPMQVVARHCYALTFEEKYVKQWEQQQQQGAWGGQKVDDDDEEILRPKPLMSFAWCFWQELLQIVNQPNPEVRKALLASLPADDSEEEEEEDDEDESEEQGQGQEATDTEKAKRPAPRKVSRIAPQLNHSVKKTPIAPFLPPEDSDEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS29</accession>
    <name>A0A1E3IS29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030043.1">
        <property type="nucleotide sequence ID" value="XM_019178004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS29"/>
    <dbReference type="GeneID" id="30195143"/>
    <dbReference type="OrthoDB" id="2574707at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="318" mass="34649" checksum="40FC92CF941F73D4" modified="2017-01-18" version="1">MPPFMLLPYHPFPKQPVTTTLANEPSSSADDTGATPEIHPQSGFLHRSFSLSTIPELDSASSSVCSSAPSPELLTPQETPEASVYAKQAAHERGLGWLSSLLGLKKSTASATKVSTSAARVTIENLPSVKTTHSFTTSRSAQHGEADTIPCCLEAPISHSDVSTLDLDALSSVSSDSDDSSDESSTWSAIIPREVYYAKTWIAGTRCEAKAQQQYALKDGSLGLLRAETENEKVERMDEWFSKSDLTVGGTHRLIKHLMCHSSPTTHVEKRTCKAEKQPIKRQKSTIALRQILSQIDLQALQASWNEDDAWSGDAWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISJ4</accession>
    <name>A0A1E3ISJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030051.1">
        <property type="nucleotide sequence ID" value="XM_019178012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISJ4"/>
    <dbReference type="GeneID" id="30195151"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000009">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="267"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN91425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="575" mass="62995" checksum="52DFEF599BAD2A1E" modified="2017-01-18" version="1">MLFRTNLKGSALLNTPRLNKGAGFTREERQIFGLEGFLPYDVHSLEKQALRAYNQLCKQPSVILKHAFLASLRDQNQVLFYKLMQDRLKELLGVLYTPGAAEAVAGYSSLFRRPVGCYILQGHLSDINRTADVAYDSQNPNDAIDLVVVTDSEAILGIGDQGVGGITISTSKAALYTLGAGINPNRILPVVLDCGTDNHALFSDSLYMGWKRTRIRGKNYDKYIDRFIANCRELFPNAIIHFEDFGMANAYRLMEKYKDIPMFNDDIQGTGAVALAALLSAIKVSGSSLADQRIVIYGAGSAGMGIADQIKDGLQILNGLSPSEAAKRFWCVDRHGLLVQSQGNALRHSQLPYARPDAEVQNWSKEDEEREGYWLMDVIKNVKPTVLIGTSTHSRAFNEELIREMGKHVERPIIFPMSNPTALCEVDPTDALAWTEGRALVATGSPFPPVPLADGKEYVVAQTNNALIYPALGLGAILSRSKTISNSMLMAGVNSLASLSPALSNPEASLLPDLADVRKVSVDVAAAVVRQAVEDGNAYDEVTIKYATGKGESSLEDYIRSRMWDAVYRPLELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISR1</accession>
    <name>A0A1E3ISR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein Mis13/DSN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029843.1">
        <property type="nucleotide sequence ID" value="XM_019178124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISR1"/>
    <dbReference type="GeneID" id="30195269"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="70651" checksum="DD489A7BE8BEF37F" modified="2017-01-18" version="1">MASRRSTRLSNELDTGGKAVNGKRKSTAGGRDDEGDAAQPKKKKQGSKKGFQPQPVSLPDSSNTPPEEEIPLNLPPPPPSTKPARRRDAARRPASESPPPHMTLQPGPNPAKKQKVGDKNSERSRGKSVEQSSRDVRGTEDDPLAGVEETASMRQSGKAPAVPHLSFKRDKPRFSEARPASPPRRTFSSNPSRAGSSKTPASTKTAMGPPVGFVRKTRKSIVPQARTSEVLTHYAAPLVESETPVINRNKEYRQETGRRGSKDRGGRASTSFGRGDITMPHKSIDYRMLYRHLPSGLPDPHRARILLTWNANQATREALRHKSSSSKGKEKETDTRRTDGGDSFIREIMDDFHHKMSKGTVETNTFSSIGDETEPFSISGLRPHPRNVANRRTEAEIASVVRRFKEEGAHWSAIATAANSRQQDTIRRLEKKMMANADPDMSKAPTWMQQILAVTEEIIAQPDLDPSLPLASSSAEAQAEASDNASKFEEVEFKVDMIHQTSHVALQYVMQSSRFLDGIFSSLTADLRARERLGLAPALPPPDEDGPDTVALLAAARQSAAASTTSAPKKPRLDAMSLLRSLATAEAKTQSEETVAAAAKVAPMPAMSSMTPRRPGTGVAAGMTPRRTGGLKSVMTPRGMKGYTPRGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW34</accession>
    <name>A0A1E3IW34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030457.1">
        <property type="nucleotide sequence ID" value="XM_019177706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW34"/>
    <dbReference type="GeneID" id="30194839"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="44399" checksum="BCCEFEDB36422094" modified="2017-01-18" version="1">MPQKIVLDTDPGVDDVLAILLALASPEVDLALVSIVFGNTHAPVAHKNLIKIYHQLAKEIEVVPGADARYERLRGAEKTVLALGEDGPIGGEKAVAAYFHGPDGLSNISETHPHLTPPEIAHGEGHEHLEITSKPSYQAILDLLRKEPEDTVTIVALGPLTNLAHALRAEPETFQKVSRVVWMGGAFESPGNTSPVAEFNCFADPYAAAAILDATKAGKIELILAPLDITTPHAIPFYDLIHPSVVPIANETGKVPVKGEPTPLESFTSAMLVRVRGLQASFGLPDSMEMHDPVAVWFALAHASQKRGSAPAAGWRLKPREFLIERNGELTRGMCVVDRRGTGETGVDRSKDEKIKSQGLGKDELPEKDEGTGRMGETIDKTKNLPLVITHTPGTEVLREVLLSRVFGREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW3</accession>
    <name>A0A1E3IXW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030562.1">
        <property type="nucleotide sequence ID" value="XM_019177409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW3"/>
    <dbReference type="GeneID" id="30194535"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="433"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="962"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN93457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116545" checksum="D337E1B4ADDEEAA6" modified="2017-01-18" version="1">MAIPPSHAGTSAPQWRQFTFFDVHDVKDTHDLDQSPRAIRQLTPPLAVTSTTSQSPLPPSLILASGQTITQVDRYFTPERSFTAWERNGRATALLEAGGLLVGIGEEDGSLWPVLKVWDLTKEDKKHPERRPVLLRNVRIQHGQRPHPVSAVALTTTLSHLAIGLGDGTVLLYRHFLQSLTTSPTALTSLPKARVVHQSHEPVTGLGFNEQSSSSNLFIVTTNRVLCAPVSGKGEARTIDELGCGLGCAVMDWERKDMVVARDEAIYLYSPEGRGASFAYEGPKSSIAVFNHNLVITSPPFHPSASSNSATIRHYVKANPNGDSPSVDIAKITVFDLQNKLVGYSGTYKDGVRDVYCQWGGIYVHGGNGKLARLEEHSTQAKLDVLYRRNLFTLAISLARQQGLGDAGVSDIHRRYGDYLYNKGDFEGAMSQFVKTLGNLQPSYVIRKFLDAQRIHNLTTYLQELHSRGLANPDHTTLLLNCYTKTSDRTRLDQFIKTEAHRTDTGAEELPFDLDTAIRVCRQAGFYEHATYLAKKFGRHEDYLRIQIEDAGKVGEALRYLRSLGPKACDENMVRYGRTLLHQEPAATTALLVDLCSGNLGKKKASTPPQIVEQLNGTSNGTNGATGPAMLSYLGYNKVSGLFTGEATGTATPTDKNEPQRVDPEETSALEKLAIESEGPDYVPPSPRQYFAHFVDHLDLFVHFLEAVALNLWDQKVDLSVPSSAPSPIATREVDIPPPDDPTGVDQRAVWNTLIELYLSATKSLDSTVASQSREKALALISSKDTPYDPLHALVLCSVVGFRAGMVRLWEGMGMYEDVLRYYMEAGEDDGDEVDASAKVFSHLDLYGPTHPQLYPLVLRYLTSSPAILSRHPKELGNILAKIDEYQIMPPLAVVQVLSRNGVVSVGNMKDWLKGKVEDNEAEIESDKQLYDSYRADTAVKRKAMLDRTNPSQPEVFQVTKCASCGGQLDLPSVHFMCKHSYHQRCLPDSDPECPLCARQHSVIKEIRRNQLRLADRHDLFLEEVHSAEDGFGVVADAYGRGLFGREGDVLDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXY6</accession>
    <name>A0A1E3IXY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIIA large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030564.1">
        <property type="nucleotide sequence ID" value="XM_019177411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXY6"/>
    <dbReference type="GeneID" id="30194537"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="223" mass="24824" checksum="5C7574AFA5D7877B" modified="2017-01-18" version="1">MCPETYRVVIDDVISSVKVDFEEYGMEEDVLQNLQAKWEAKLLETRVADFAQTGADSPNLQRAKAELHSPPTGPSHHQPDMYPFSRPGVPQQGAGGPGPMANIYRNGGVQQQEVRVKPEPRYDGEDDPLRLRGGAAEDGNKPEPNAAGLLPGDDVIDSDLDDSDDENRGDAEAEDEDDVDIVFCVYDKVQRVKNKWKTVFKDGMIHLNGKDYLFAKCNGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY03</accession>
    <name>A0A1E3IY03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030533.1">
        <property type="nucleotide sequence ID" value="XM_019177380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY03"/>
    <dbReference type="GeneID" id="30194506"/>
    <dbReference type="OrthoDB" id="2572819at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="838" mass="89349" checksum="B85477D940312C36" modified="2017-01-18" version="1">MDVELYSQEEEPSFRVEETDPMEVVKSQSDTRSQHPQLYASLAEYSLQGPRTFPIVQFPDDDSTPTFAPHKSIHHHQRRTTPPVPDCRPGPSRAGPSSDFVMSAAPSMSRAGSQSMSRTSSQSMSHMGSNASQTAPFSRVSIDRALSERPRRPSPHLHEIQPPSRRLSSHQMLLLTPFGGQVPMGTLPGLPLKRGGAGMSRGSPSLGTAEGVSRSGSRSERPSVPPGLHPRREGRSQGSRSSGTGVGIGVGAVDLGRDVTVAPLVNLPLRVRQSLGAIGSVTHHSPLASAPMATITSQGSSGESRSQEEREVSSSAFMSRDEVDMARHRKASASTPYRHSATSGKRAIEHSEPQVMPTTVAMSRFNSLPVLTLRELEALIDKDGELGIQRGGHWAWVSREVKVDEHGNEVCVGSISKSVDTDASIRRDKFPQGPVSQRPILGAMTSPSFSDPFPSRFGANNTQAFIPIATSTDYHYSPTYNHRRMSEAPVSPTLEGNNSRRPSMPVSLAGSARASLAGYTPRQSINLASRLQSVSVGPLENQALKSRKSSLASTSSKQGTELASPGQSPGGTPVTISPPPRPRITRYKSSPARSSGLGLNLTLVQQAEATCDATSRRGSATDEMGDRRMSTVVVGHWAEVDFIDPVAATVALSPSAAPVPLGSFPRPPAPPSEASSGASPTTATKVLAPSRGSITPIDSDHSLAIHNAHHAHLIDWFSEFSFRGRDRFESIDSALPLMPGGGGTRLSVPIQGAGDGYHPSRGASVTSTDSRPSGLGGGSEVEGEMPRRGSLGVGAFARLRRGISRKSSEGIGEDKLLHREGRHWSDRRGSWAESWGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY91</accession>
    <name>A0A1E3IY91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030298.1">
        <property type="nucleotide sequence ID" value="XM_019177547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY91"/>
    <dbReference type="GeneID" id="30194677"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="517" mass="58404" checksum="BC9D46E70EBA7303" modified="2017-01-18" version="1">MASSLQHLHAGLRVIKNYTKGYTDTQTKVRDATSNDPWGPSGTEMNAICQLTYNQNDFVEIMEMLDKRLNDKGKNWRHVFKALTLLDYCLHGGSENVVIYFKDNLYLVKTLKEFVYVDEDGKDVGTNVRQKAKDITNLLQDDARLREERRSRGAMRDRMLNNIEASGLRGERDSGAPRSSAPPDSPPPRQRPGRSRNEDDELERAIAESKRMSEDEAKRRSMQTQEEDELRRAIRESEEEEARRKREQEESTKSALFDDNLNLQGQNAYTQQQPDLFAQQTQQMPMQPTGGWPLVDAGWGQQQQLQPQYTSYNPFFAMQQQQQQQEEYMRQQMALQEQQRQQQEWAQQQQYLQAQNTSLFAQPTGYGSNNPFAPGGGQSQPPVPSPQPQQQSSFLPVPSVTQQQPQQSFSPQPQEPPKQLEPQATATPSGWNGTLKTNDAQHGGLASLLARGREDGLDTFGNQGNLRIPVGSGFHDSNRVAAQQTGAAGLGANNPFGQRMQQQGQQNGQTDQPFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZW1</accession>
    <name>A0A1E3IZW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030551.1">
        <property type="nucleotide sequence ID" value="XM_019177398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZW1"/>
    <dbReference type="GeneID" id="30194524"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="226" mass="24742" checksum="441FCD30852DA239" modified="2017-01-18" version="1">MESYALQNFPPAHSAIHVALFHNVTNAPQIRQRLIKASQYPPGEEGDKARADVDFGFVEGDLLVSKEHLLSAVLATLLYAYPSTSPAPTDPPSLSSPDISSLSLNSEQDRVPKTRSHNLHSEILLLLSPNNNISDSIRRHGLSEKTTRLAVVKFGKRGQSSEEIWKAMEDVVEGELVGLERVGEGVDWAKVDKVYKLSELNALKTPDVIEKKKAAVVSTVAVKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1C4</accession>
    <name>A0A1E3J1C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030969.1">
        <property type="nucleotide sequence ID" value="XM_019176937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1C4"/>
    <dbReference type="GeneID" id="30194044"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="35278" checksum="AA3311B5BDA773D3" modified="2017-01-18" version="1">MSLLTTLPRGTPLRSLRSLSTSAPRIAEAAPAALPRYVRKAAAPAKGGYKSSSASTAAKAVPAYPKYTRPTAAAAKPAAPPVAEAAPESFPDMPFEETLIEDYAHLAPPNAAPSPPLTDLPDQSYQPLPSATTPENLGLGQGNKIPGEAAVGQDWSTSFAGLSEKPFPRETAEALLRELKPDDVEIKPDGLLYLPEIKYRRTLNLAFGPGGWGLAPRGETHVGPRIVSREWGLVCLGRLVSVARGEQEYFDPSGIATATEACKSNALMRCCKDLGIASELWDPSFIRKFKKDHCLEVFAEHATRKGSKKKLWRKKNAPKFEYPYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1W2</accession>
    <name>A0A1E3J1W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04971</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031103.1">
        <property type="nucleotide sequence ID" value="XM_019177071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1W2"/>
    <dbReference type="GeneID" id="30194184"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="101"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN94824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="421" mass="45971" checksum="E3BAD1D80C69A457" modified="2017-01-18" version="1">MPKDLNYSPASDEEEDRDEEEIDEDDLPGPSSRAGNGAKGKGKTKDPGRAAWEGEYQKSWDIVQEDEKGSLESAVESLLARGRRKRALMSEAPVRRSIIRHMFILVDLSESMLDKDYRPTRFEVVLNYLRSYIPEWFDQNPLGQIGLITLRDRLSEVLVPMGGSPEELVQALSDKRRLEPSGEPSLQNGLLMAKSGMEHLPGTSSLEMLIVFSSISTADPDGPKTIHTTLSEIAQTHIRTSILSLSGEIKICKQIAEQTSGKFGVALDQEHLRDLLWDTIPPPATTIAPATLGVRNALAAGGRNGAAGKAPAGDLMVMGFPIRLPLGGETMCACHGLLKKGGYLCPRCGSKLCDVPTDCEVCGLMVVSSPHLARSFWFLFPVANYKTLSFEEVDVSQPETCFGCDSPFPDVSLLLYSLAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J239</accession>
    <name>A0A1E3J239_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031004.1">
        <property type="nucleotide sequence ID" value="XM_019176972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J239"/>
    <dbReference type="GeneID" id="30194081"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24603" checksum="849B215AFA078610" modified="2017-01-18" version="1">MALPQEILPQHPSDPLLLLPVPNPLPPTPTPSLPSLLAALAPHLTPTEVEELEKVPIPVLTSTIRQFTRHSQTLLNAARAGVTEAREELDEVDVRLREVEYERERVREETERCEEYAQTHGDVELPDVETFLSSVDQTPKESESYEQTLGILRLEHELGEILKREAQVAQITKERDAYIKAKKEIKVKSDAVDVHLAQFARVRPISYSLHQVNTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2R8</accession>
    <name>A0A1E3J2R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complement component 1 Q subcomponent-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030782.1">
        <property type="nucleotide sequence ID" value="XM_019177201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2R8"/>
    <dbReference type="GeneID" id="30194320"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="265" mass="28765" checksum="BE077ACB358C262A" modified="2017-01-18" version="1">MSLRTALRPALRASALSTARRAAIAPVLRPLARADGCGDCGCANPRAFSSTPFRLGSGETDSTLSSALAAEHKYELEAANGEAEVPVFIEAFKAQGCWEIDDIAGSDDVVIIRKFGNETIKLTFQVSDLDAIAFDPEVPVNDQEEPAPGPASITCTLQVTKHAAPSSLVVDLETCDEGFEITNVAVFEKALADAKGAEGDWERRSRYMGPQFDHLDETVQEAFGAYLAERGVDESLADFVLSYCEHKEQKGYLNWLKEVRGFVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J315</accession>
    <name>A0A1E3J315_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate/3-mercaptopyruvate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031228.1">
        <property type="nucleotide sequence ID" value="XM_019176753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J315"/>
    <dbReference type="GeneID" id="30193849"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000064">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="197"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="337" mass="37385" checksum="EC58A6F55B13FC7A" modified="2017-01-18" version="1">MRFPAPASPFFRRAFATSASMRVPLLVTPKQLKELPKQTTLPLDASWHMPNSPRSAVAEYLHGPRIPHARRFDLDEVAELSVDKNPLSLTHMLPTKERFQKELEKLGIEKDTHVVVYDSVGVFSSPRALYTFKIFGHDKVSVLDGGLPRWIQEGGEVEMGDVGDVGASDYGKIESYHKDWVRSYDEINKNAEKPLSDPSTEIILDHRPAPRFTGAAPEPRPNLPSGHMPNSLSLPFTQYLNPASDKVPFSSYKPVDELKAVLVKGVGGEERWGEVECGKKVVFSCGSGMTAAIGWLANELVKEGGSKAATSALYDESWTGYALREESKISREGFYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3E9</accession>
    <name>A0A1E3J3E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030915.1">
        <property type="nucleotide sequence ID" value="XM_019176883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3E9"/>
    <dbReference type="GeneID" id="30193988"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40076" checksum="780B75D83CEA5346" modified="2017-01-18" version="1">MSKTLLRLSRIPRETYESVNANRENKFGMTTVRLRKLRDAWSEFDWIGGLRLLQWLEDPLGIVLMSGKRRKQEEYINSHPQFISISKAKDGKDLKIQFAALFSRNFLEFYGILDLVKKQYTPETLPYHIIVPYLLGYAFSSPPLEGPFSVQDVAFVLNNLMKGLGFGGGYMAQGGDVGSFVTNALGMYPNECKLIHLNFRLSLASASGSTESKKPTDKAFDPLLPLQTFGYALEQGTRPSTIGITVSTNQLSLLACIGEKYDACPTLSFSEEVLLRFMSLYWFTHSFSSSIYHYRYMIFWYRSTSSQRGDAVPKDPHGIQRFPKYDAGGHFAALAEPEALWSDIEEIIKENWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4M7</accession>
    <name>A0A1E3J4M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031467.1">
        <property type="nucleotide sequence ID" value="XM_019176539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4M7"/>
    <dbReference type="GeneID" id="30193633"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000033">
        <property type="entry name" value="Sulfite reductase (NADPH) flavoprotein alpha-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="669"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN95802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1057" mass="112699" checksum="A69A03D283301D2B" modified="2017-01-18" version="1">MAPVALTAANASPPPLPAKKAYAAAQLNAGLNLDADGASTPYSATSTAVSEYDGAKDKVSHPASPSAIAKALVESTIPSTLPSPTDDGYYANLIASSLPTVATKPGATVFASAVDALEALAVKHSESVWVYDDAALVEFGARVSKSGSKKVHELQTRQGAGLELAGYASKTQGKFTIFASIKTLQYLLPSIDKIEGDVLINLATTANHESLEFTDGLYASGTLKALASLPEDWEVVFSSGDKIIDTASKLYAGEPRKVIHVVESTYSGRETAAYTFPAPQPAAIEDLTIQNGSATQLYLAPAGYLASGIAAVLPASAGLVQLNTLSPSSDALFAALTTEGGRKTVQVLGATKADAEALKAVVLASLYAASGSSKSVLPLVKSLVAASVAAIPDLTTEQVAKPGKVVSFFTAPTSPLPQLLAHLFLSSPSLSTRLAQFGSASARGVRSVLSLAPASTPAAALSVEEPSDVTWLSDANVLKSADVLASAKQGSIVVVALPWSEEELPVKFTRSEIQTIQSKQLRVFLLDLAAAPTTPIQEQVAFLLLYTGTSKLSQGVWKVLDAFHNHQVAREDVEAAQAALFEVNAASWEIPELEEGKTEKVKSQWEWDALPGLAGVVASSDEQGSGMGPWDLAARHLFFREAFAVPSAKTTDNAQGLPGVSALRPSMSEETFLVTVSENRRLTPQTYDRNVFHLELDTAGTGLHYDVGEAIGIHGWNDAEEVREFCEMYGVDPDSLVTFPSPTRAGTLESRTVFQLLQQNVDLFGRPGKAFYAALAKVATNKSEAMRLKFISAPEGAELFKRMAEKETVTFADVLKGFKTARPTIEELVGLIPEIKPRHYSIASSQKAVGDKVELLIVTVDWVDVHGSPRFGQCTRYLSALAPGSKVTVSIKPSVMKLPPDDKQPIIMAGLGTGAAPFRAFMQHRAWQRTQGIEVGPLIYYFGSRYRSQEYLYGEDIEAYIASGVIAHAGLAFSRDGVDKSYIQHKMSADKALLSKLLKGKGSDAAYFYLCGPTWPVPDVYEALVGSLTSEGGMERKAAEDYIEELKEEERYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q5</accession>
    <name>A0A1E3J4Q5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031499.1">
        <property type="nucleotide sequence ID" value="XM_019176571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q5"/>
    <dbReference type="GeneID" id="30193665"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="230" mass="26050" checksum="EA6626ADC1D9091B" modified="2017-01-18" version="1">MASLLSLPIANRSAARTALSLTHTARRTSSPPLQHLRSFGVSPRRSLSHFDTYLFVEKLEKNGMTRESAEGVMSVLAEVIEESIKGMEASLVSKAEQEKQRYTEKVDFARLKSELQLHEKNDLTLMKAENDRLMADVEKLKQRLREEVTRTQAGVRLDLNLEKGRIRDESSQQELKIKEVDTRIESEIAGLRTQIEQAKFSILQYLVGVATGSGALLIARNQLAYMRMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5K9</accession>
    <name>A0A1E3J5K9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031211.1">
        <property type="nucleotide sequence ID" value="XM_019176736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5K9"/>
    <dbReference type="GeneID" id="30193832"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="114" mass="12056" checksum="CEB4DDDB97A8C1E5" modified="2017-01-18" version="1">MATNTNSTQQTTQSDAFLQCCFVIMKAQAKDKKADALTRVVVHSLLSFNILAIPQRERTLSSQNIQPIVDRVLSDPSVSRSGSATLPSGESVTYTYVPMTGGAYGSGGNKQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J727</accession>
    <name>A0A1E3J727_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031571.1">
        <property type="nucleotide sequence ID" value="XM_019176643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J727"/>
    <dbReference type="GeneID" id="30193738"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="209"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="645" mass="70265" checksum="40D9C52C75FC7D70" modified="2017-01-18" version="1">MSYQAVPLNDPSQDPAPPPLPPKQPFPSSPYQALPQSTARPSSRPTGSSPSSIPRVPVPSSNRRYGPSASSQGSSHESYQPGPRGASMPHNGRDPRRDSQASSSALLGAQGKGGAGAGVADPAGWGAMTGGPEDDDWMHNEDPAHDKRYNRFDAFSSRGIANVGCLFIGALGLIALFAGYPIITFYTQKHQSTNGAYNLGGINSTGQIPLISNFPSPIDEDTPSDVYTRTGFDGEEYSLVFSDEFNRDGRTFFPGDDPYWTAVDIHYWPTGDFEWYDPGQITTRDGALVITNNQEPIHDLNYKSGMLQSWNQMCFQYSVYIEVAVSLPGTNRVGGFWPGVWMMGNLGRPGYGATTEGTWPYTYDSCDSGTLVNQTNAAGTGPTLALTSGANDGPISFLPGQRVSACTCEGEDHPGPTVKHGRGVPELDILEAQIDLDIPQGQVSQSCQIAPFDPSYEYLNTSEGAIQYDTDLTSWNSYKGGTYQEAVSSLTYIDNANYVETRGGFGIYGFEYYTNPDDRENGHITWVANGQRSWTMYPASVGPVEDMDIGQRLITEEPMAMIINFGMSNNFQAVDFANLVTPAEMLVDYVRVWQRSDGYMGCDPPDRPTATYIENHLAAYSNPNFTTWEEAGYTWPKNSLIDGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J771</accession>
    <name>A0A1E3J771_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031771.1">
        <property type="nucleotide sequence ID" value="XM_019176361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J771"/>
    <dbReference type="GeneID" id="30193453"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19260" checksum="7359981937533FAB" modified="2017-01-18" version="1">MFFLRELTHTILLHPSYFGAQLEDYLRQKLYEDVEGTCSGKHGYIISVVQITDIGEGKIMPSTGQAKFRTGYTAIVMKPFKGEAVDAKVVNVNKMGFFAMVGPLQVFVSCHLTHADMKFDPSVSPPCYRSNDEVIQKGTKVRIQIVGCRVEANDMFAIGTIKKDYLGQIRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8U6</accession>
    <name>A0A1E3J8U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031895.1">
        <property type="nucleotide sequence ID" value="XM_019175982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8U6"/>
    <dbReference type="GeneID" id="30193069"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN97293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="388" mass="43050" checksum="5BF943A2611C3AA9" modified="2017-01-18" version="1">MPAEDHQSASPASKAFASSLARYAYVASSSSGTTSEDTSAHLKRSVPGRPPKHSNVEERKERTPKRSMSASPSKKAVKKPRGYAGPEVYEHLRPVNDLLSDDLDCKQSASLGHHFAHPTNKFWRLFLKVVAGLTSRLVPPTEDHLVIGEFNFGLTNLVDRPTSEQSELSTLEMRLNTYQLLLKFVRYHPSIVCFVGKKIWDVFESVVGKTVFYGGEVETVMKAETGMSQEGTERKVSILTPQKRPKMEATDDDCDNDIAMPSEIIATPRKGRLNSALSPSLISPRKRKGKETKIPFSFSKPQSIRLPHALSPGRQREYTYFFVVPSTSGLERTPLLEQVSNFRALKEAVDTIKQGKEPAGNYLDVDVSGVEKTVEDMRRGALLKGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z4</accession>
    <name>A0A1E3J8Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031942.1">
        <property type="nucleotide sequence ID" value="XM_019176029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z4"/>
    <dbReference type="GeneID" id="30193116"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63332" checksum="4144DC3201D11D85" modified="2017-01-18" version="1">MDTLASPAYPFATMPRLFILPSALTVLYSLVAVSLLSAGLYIYLYPFRLSRLSFRNLPGPEPGHWFWGHTQTLIAQQPNAMHTVWTNKYGPTICYPIFLGIQRFLTIDPSALNYILTHPESFEKPSETRGELTTMLGNGLLVAEGSDHKKQRKALGPSFSPAAIRGMIPAFYDKAYELNNKLMGLVEGADTEVASPTPAKDIDFVPGGRKIDVMSYLSKTALDIIGTCGFDYDFKALSEPSNELSDAYRNMFMAVMDVRVWDFIVSKIPIIRSIPTERSKVVAASKKLTRSIGMSSPRKEDIVMGAHGGDLEKKADIGKDLISILVKANMAAGLKPEQRLSDEEVLDQITTFMLAGNETTSTGLTWILYNLSQNLDVQEKLRKEVQSVSEDRPSLDTLNTLPYMEAVVHESLRISPPASFTLREATQDAILPLANPVTGNDGKVMHEVAVDKGTSIFIPVITVNTSPSIWGDDAAKFIPERWLSSSKDGFQPGPVPGVWGNTLTFLGGGRNCIGYRFALAEIKVILFVLMRSLMFEELKSKPVISKKTGIVMRCSIEGEEEAGLQMPLMVRPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J920</accession>
    <name>A0A1E3J920_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031949.1">
        <property type="nucleotide sequence ID" value="XM_019176036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J920"/>
    <dbReference type="GeneID" id="30193123"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="42793" checksum="80AB5D9595BD4558" modified="2017-01-18" version="1">MSTNKATSLAYVDTVYSADSIEFCPFQGFQDLFVCGTYQIIKPEELEQPKALEEDKDEEESDSDEEEFVPQSTQRKGRLLLFQIDQDCQPNELQRIETPAILDSKWSPHVRTGGGPRLAVADAKGHIALYELNPDTKRLEEVQTIDVEDETRLCLSLDFSHRLEPSVEPSIIASISNGSLSHLTPTPTGYEVSSSWHAHDFEPWITAFDLQDVNTVWSGGDDCKLKRWDLREPFMPSMVNKNFDGGVTTITPSPYTPNLLAIGSYDESLRLFDTRSPRTPLLTLSMGGGIWRVRWHPLVERMGDLLVASMHDGFKVVRLSEQMVGGDWGSLSDDDGSVIKAFEAHESLAYGADWSRLPLENEESAIATCSFYDHAMHLWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC02</accession>
    <name>A0A1E3JC02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032265.1">
        <property type="nucleotide sequence ID" value="XM_019175775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC02"/>
    <dbReference type="GeneID" id="30192860"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000380">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="497" mass="54185" checksum="3826284C211A4A1C" modified="2017-01-18" version="1">MTQQPLRTVVVLGTSYGGRNASKLLADGLPPNYRLIAIDRNTHFNHVYAFPRYTTMPQHAPKGFIPYKYMLDPQPPAPSDPLTPPQTPPAEAANLPDDQQKLSAARSRHQFIQACVVKLSAHSVTIVRPTGDGKATEGQTSRSKGNMTYGEFDGPEETIHFDYLLYALGATLPGPVNVWQTVDKAAVGDERQLGTKKCGLRFMKLQHDKFEKAERILIVGGGALGIEYAGDLKYLWPDKKITLLHSRTRMMPRYDIELHLQVVEHLAKLGVEIVLGERVMTWPDEPEILDGKPKIVTTDKGRTFEADLVLPCTGQKAHVSLMAEVDPSLISVTTGRILVLPTQQVHSGPIPSSAIDSTAEQLSKLNFTAPLTPPSSAASITTGSADGSTAPDYSHIFAIGDCAETSAIQAGHTAYWMGEVAVRNMMRLIDRREGGPKKDEVFENYKPGPPAIKITLGIVDAVIANGEGVKPNKEGVEDMHSMVMWPGLNAEGLNVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC14</accession>
    <name>A0A1E3JC14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032244.1">
        <property type="nucleotide sequence ID" value="XM_019175754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC14"/>
    <dbReference type="GeneID" id="30192839"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="367"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="654" mass="72026" checksum="850BF0D097441783" modified="2017-01-18" version="1">MLSAELSTINSQLMSHGWAKRPLRLNALSEKDHNDVVAVLFELLGASVSNLDVLETLNGRHRTLEYEYERLQKTANNFKTTNSRLDAEAQAWKFRCAEMEKRLLAEQNKTKELREENARGRKALETVKVAAVHETKKIQTCLDKALGQLAKVGDLGHKPQGLVLLNPIPAGRIQPVAVTQFPLLEQTLRDLTDIQSSLQEETEAFRHVTVTTGNALREALAASMGQEPPQGLLQSQFFTSPSTISGSRSNTSQSASSLSHPNIAQERLQSLIADLRTRITDRVPQWSPSTGEAQENLTPEEIEERKREERDAEKQQRDLHDRIKDLEVELECAKRKEDEASKVVADYAKKQIQQEVNVNDSKDDFEMEKQRQALDQERRRYAEEAVKLREQRRRLEDERATFLEDKRQKEEEVAARLAAIAAVPIATVAETAVINQPIPKEHEVPKGPSGSNWFHQHRPHSPSPLSPQGPRVRTPKAHMAGARRKSMKTPLSRLVLEKAVRQKGKAMGISELLIREKDEVSRASVLGAERGRKTNLGSSSSVRPGSPSRKGKEKAGESTMGNSVMTSFTLAKSRTSAGSTGSAGGTTRVTPPAVRALAGSSRSRTSGEKPAVPETGSMRTSTGSAGTGAARKHEIGQAGGVGPKTVGKKSVWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC85</accession>
    <name>A0A1E3JC85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032304.1">
        <property type="nucleotide sequence ID" value="XM_019175814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC85"/>
    <dbReference type="GeneID" id="30192899"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="42645" checksum="D7EF63B036567BFC" modified="2017-01-18" version="1">MTIAPRPFQADTLEFTPLPADYQPRPGQENDGRYMLTVPWSQAKGWGTPKIAMRRPLEVDPVAGVMQYAVTCFEGMKCFKTDNGDLRLFRPNKNFDRLKRSADRLGLPSDWDNKELLQLLSTLVSLEGPDITTKDGGNLYIRPTILETSGGFGVRGEALAPEALLYIVTTHNLGAATYNSAEEGAGLRLDARTDYRRAFIGGTGSYKLGANYGQSSSVVSIAKRPNYLMNLWLHDDKHHYISEAGGMNIFVVKKATDGFTEFVTMGLEDGLVLPGITRESLIELIEDHAAGRKDFPVSGMPKQVRVVERNITMKEIISSLEDGTLLGMFGCGTGVCVAGVAEITYQEADYKIPSNPLIILIRDALTGLYKGRIQHDDWSYRVPQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCD0</accession>
    <name>A0A1E3JCD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein sog2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032400.1">
        <property type="nucleotide sequence ID" value="XM_019175910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCD0"/>
    <dbReference type="GeneID" id="30192997"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="133497" checksum="094BDC8C64EC46E2" modified="2017-01-18" version="1">MFSSTPTLRNGLSKDNSGVNGTFRNGSTLPPSNSSSHLSEDAYNKDEADMKSGLRVDTDFLSKAPSQYGDAMLDSSSSREYINAHSPIEPVVKGELACEGVAFNSRNDVELAVRGLRDLSSPSPPPPPPKSTNRPGAGAAPSVESESRITPSISNASLDELLQRDQKTLKMVEEALERSEDEGDTLDLSRRAIDRIGDRAVDMFNCRVGKNQKGVWRLALSYNLLRDNSIVDSFGKLSRLRYLNLKGNHFTKFPVAITQIPALEILDFSKNKLVSFPDDPGHLVRLKVLSLTNNEIVHLPENFIKFGALKVFKVDQNPIEWPPRSILGPLCESISAGRSKGSLHDRKRGKEEDLRPWIESVKMWMRQKNEPQESGQPNGSLGYQQAEERSQPAIVSSASEMPLGPAQPAPRPWQQNQRSDSHDSTANNIRSTSPNVNSHARNESTASYMSPPSSSTDASFRSHARSPSVTFAQNTFLSAQSHTRGGSYSPGQSSVSNLTAKKSLPDLRLSHARIIEERRGDMGGEMATGTVSIMASMPSHPYRSSTSVAVEGDISPSPDLAPGVDDLTSLSEKRSSQDRVIDESRNSYFRRLSTLPTSTISKAIPVFLLRFIDATRGILFAISQLHSSLRQYINFAVNERVAGTFKRVMEPAGVYMNRLINALDRFDAMSRRGTPPTAAIRNVLDAAKESVSVFGKVAAVLKMQVPAMRGNDIRYTRTLMVNVYGATAEMASSWKVMAGLMPEAKVLLFVDATGSRIPFNTDSSGGQPMAATGSFTGRTISPIIERQESHSPQSIRSEVPATGHDESLGTPLGHQGRRRGQGHPLSKERRHAGSYSGQDVERGMMMGSPLPEASPDSKEDEHHHERAESGTITLPSPEDEETSEYGAPNHAMAHMDHPHPPFAFGERGHHPSSSSGSSHAMSLASGFAYPRKLSVDVRPPTPASATLFDEDLLDVIETATEVAFTSWLRLSEDIGASPSLPNHGIHHQSQPSNASSRNIDMGFGHTSKRPSNITPKQHTELIHLLSVAEQTTATLRESLMRLRANPSSLPTTTLPDDAQAFIKIVVKVSELVKAMSGTHSFPVAVRQTVGRLTQATRECAILIQVSSLRPGQGTPAPIPPSQSASSRSAFFSSRTDLGSEHSIDVASSHDEYEDIAVPPSAGYAAVHHGLRDLQLPSKQAAIGRSRSANATVPGQGSLGSIVMPIPYVSGGAIGGRGAMEAPRSAQPGQVFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFC9</accession>
    <name>A0A1E3JFC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032619.1">
        <property type="nucleotide sequence ID" value="XM_019175516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFC9"/>
    <dbReference type="GeneID" id="30192599"/>
    <dbReference type="OrthoDB" id="10366029at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="24278" checksum="7C832A15D5DD3786" modified="2017-01-18" version="1">MDQEEDILASYSPATVETPGLSYVQDEWIAPWSPFAPDGDETSLSLQAACAAFMESDPQAMEDVQYILNSLDDGSEMPFSNGALGQIGGDASVSSPPILSATDESFSLISPSLTSPSLITGPPPHEADLPPPRPARTNTFSSRASSDNGSTKRQRVASAVSSIDRRRGPTDRVSKIDSSSLITQSSKKHAPMVSRVLSKYTWEQLDEKDDRNEEEQAVRDLIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFK1</accession>
    <name>A0A1E3JFK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032681.1">
        <property type="nucleotide sequence ID" value="XM_019175578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFK1"/>
    <dbReference type="GeneID" id="30192661"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN99604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="244" mass="27350" checksum="7E6FE2FCCE31B3BE" modified="2017-01-18" version="1">MDAELQTYKDQLAYVNLSLESDATNDDLLKLKTELVELIDLTEQAMGHSAGGSKGGDTSGKGKAASKGKEKEVTNWQDQGQYKAGMDCMAKYKDGKWYPARINAVVGSQESPLYTITFKGYTSSTNVPLSSLRPHDPNAPIPQPQKRKNEELTEKEKEKKKKKGDKWMETQKQRADEVKEKKNAWEKFGKKATKKGIHISGLEGKSVFRTPDNPYGRVGVVNSGRGVTNYERMGKHKFDEERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI90</accession>
    <name>A0A1E3JI90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032793.1">
        <property type="nucleotide sequence ID" value="XM_019175061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI90"/>
    <dbReference type="GeneID" id="30192134"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="71126" checksum="9AAB1D08F92F622F" modified="2017-01-18" version="1">MSGTPRVLPTLSSWYDAPKGGSSIINGPDANEIEVLKARLADVEGTIHRLSEAFHSGHRHSSGSHPIIAPPTHRIDPQLHTPSQSSWEQPLDPALAPENDAIMNGESPLAAAFVDLPVPDAISRGILLMDDCQEAFDFYFDRIHPWTMILNPHEDGSAATVRQRSPILFHTIILTVFYYRPTSTTSLVMYRAISTILYSLLGPLLLSSQPPHLFSDTLRAIHLLDLYRPVQYDNLWLSGETSPPAIQYRSKINPQGAWALRNLAGQIVQRMNLPHAGIEFERCSNAGVPTHPSIIADVRLHLALAWHDIHGALSGGSSQHIVPPSIALCRLFAEKRFEKYDVRLAASAELFTLAIKLIRSPTVSPGEVYEFNSSLDQWCGYWQLQLKSNAYYDPYTWSTINMYGAFICLLLNAYALGRSRSWSSLESVTDGQVQYITQVKAGVQRLVLAVTEQKADMGEGFVATRWGSTVSARVWEELELDKDIIDTMQWCGDSVAAVMYPHALILLIRLHTSGLLFPDLITINPHTIPTPQPSIPAGSPLANLLTLGDSILGSIAPNAEHPVGVKANYIRRLRGPFVPEGMASNKFNGSGTRARTPRTSMGAPSLDSPGLAGEGGGKGQEVRDLKSWLEVNFGDKVIFSSGWGPSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIA9</accession>
    <name>A0A1E3JIA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD dependent oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032816.1">
        <property type="nucleotide sequence ID" value="XM_019175084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIA9"/>
    <dbReference type="GeneID" id="30192157"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68536" checksum="EA862E608530B6E9" modified="2017-01-18" version="1">MSDPSTRDIEHGSANGMTQDCTHRKKVLVVGAGAAGMSTAYHLSQHPEKFDVTLTLIDAVDYCGGQAFSIPLDKDRYGASWCNQGVQGGSYIFHHTVTMFQRQGYHADPCNLQVSFGKDDTFWSNVFPTEILVKHQREVIRLAWMLKWIRRLELFFALIPLRLVFKLFMFSEEFINIIALPMTALFLGTGNATPQVPTIMFERLCTSPTYGMWFPPDKNTVVSNQPPMIVFPKFSEFYDTWRKDLEDRGVTVRLSTELAEVVKRDKNGVVVSLRKRTPAEDGHNPNGADKDVSPSEEQYDELVLCCLADTAKKVLGKSANWKEKKVLGSATFSDDITITHNDSDYMKKHYENFYRPDLAVSSANGVDQTERMEAAKEDFRPMYYIKMYPKDPSKLEMCFDCTNYQSQFPPNVPFEQHVFQTIYLNTARDGHLWSDDEIETDKIIRRDWWHQLCHGWTHYLYVIPWMMFLQAKNHTRFAASWTLVNAHEIAVMSGIAAAVSLGAEYPEDLEHDKFAFLSFRLYYLIAYGKWYSRNFTSKKRKAQVESEAAKAGKGWATGLCGSMYQGPGVSTVERSTWKKEMKEGTSTGNLAEARGNGRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKZ8</accession>
    <name>A0A1E3JKZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032989.1">
        <property type="nucleotide sequence ID" value="XM_019175257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKZ8"/>
    <dbReference type="GeneID" id="30192337"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51863" checksum="54139315D34CB1C7" modified="2017-01-18" version="1">MLARTIHPPAPSTGLLRPALAATRPLTTSFPARRQRDPPPRGHVRPAPPRRPIRPSSFPAASPNTTAQYAPFSVEGIDVHTPVYQSGHVNIPPDPEGVLGDSHAAREVLGHESLVVVRQLEMLNVFMGFEQANRYALHSPDGQLVGFLAEEEQGYLSAISRQMLRTHRPFRSVIMDRTGKPVLWIRRPFAFINSRIFVHSSEAADSTLVGEAQQSWHPWRRRYNLFQTREHGETFRQFAKIDSGFLAWDFWLKDRGGRLVASINRNFRGLGRELFTDTGQYVIRFDSAGTELDLAPGSNVNLQGQSLILPQSSEGGLTLDQRAMALATAVSIDFDFFSRHSGSGGMGFPLFFWGGGDGGADAQAGSRPSDVQGSDVAGGAAARAMGSAAGGLSEDEQIYGRQPPSAESGSAPPPAPEQGQYGWPETWPEDMGGVEGLEGYQEQAGWSEDEVMQDPWGQQQGGGDDGGWFGGGDGGWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL79</accession>
    <name>A0A1E3JL79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032884.1">
        <property type="nucleotide sequence ID" value="XM_019175152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL79"/>
    <dbReference type="GeneID" id="30192231"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14146" checksum="99743B42D3A0C706" modified="2017-01-18" version="1">MSSAEASTSAPVILSVAPSRNGRTPGKAHKSDKSAVRRSYISPSIKTPFDKRKEKEAAINANKTLEKELKDEKEAERQRKVNIIKERRVKKEEREREAEMRARMSAKKLQRMKKRQGRSAKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLV9</accession>
    <name>A0A1E3JLV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033045.1">
        <property type="nucleotide sequence ID" value="XM_019174666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLV9"/>
    <dbReference type="GeneID" id="30191731"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130482" evidence="2">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="305" mass="30111" checksum="92E11B63E9DD6811" modified="2017-01-18" version="1">MLAFIPALAFLLPVLAQGTSNGTASDVDIEGLEANFQQAQIVPGLLETFTPEGILSVEFAGQAITTGQNLTADDVSSSPTLAVSPASNATLDSSALYTVVMVDADIVGTDESSTQQTRHWLVNSAGIESGSSGSQAVNWTGSTSITDYAGPGPDAGSGAHRYVIIIYEQPSDFTAPDDLSTPGTALGQFSLSDYVSSSNLGSIVTANYFQVENGVATVSPSSTTAVESSTLAGYGSTTVSSSASGTVANSGAASDASATGSSTDSSSSSSSSAASSAAGVNTQVGWGMVVGAVGVVGAVVGAGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM08</accession>
    <name>A0A1E3JM08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033161.1">
        <property type="nucleotide sequence ID" value="XM_019174782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM08"/>
    <dbReference type="GeneID" id="30191851"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="114" mass="13370" checksum="47E896F1BCAC719E" modified="2017-01-18" version="1">MEFAKNMRVVFKIHEDTSTRTYSIVPLVEEESENAIIKHIEWRTVDTAGRSQQKVQYLLSGADQMWTRMRVRFKHGVHNFPQVARDFLDKKECELVELTTHSFPFRKAGTDTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM95</accession>
    <name>A0A1E3JM95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_02716</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033237.1">
        <property type="nucleotide sequence ID" value="XM_019174858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM95"/>
    <dbReference type="GeneID" id="30191929"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODO01985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="395" mass="44847" checksum="D2FAAE42231EEE97" modified="2017-01-18" version="1">MARPMLSTSRIMCARSFTSTRTLSQATQLRHNSLSLQPGVREADERRHEPTVGSEGKGVEGPHPKGKCFQSHQTSANALSDATGPWTLFNPIYTDKIRQPLHLCTSLMPHQELNTVQVIERTPITAGDKVAKGIVKSLRRVFDVITRYTPYEVPESVLKQNPIPIAQLRADGKLLSDHKWLFRIILLESIAGVPGMVGGTLRHLRSMRLLKRDGGWIHTLLEEAENERMHLLTFMTIAQPNWFTRAIVLAAQGVFYNAFFLIYLFSPKVAHRFVAALEEEAVRTYTHCVKDMESGLIPEWQDKPAPRIAIDYWRLPGDAKLLDVIKAVRADEATHRFVNHSLANLDQKRDFNPFALAEASPEDRGLKWGYTREESVLFAQRQQQKLIEESTQKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM97</accession>
    <name>A0A1E3JM97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033226.1">
        <property type="nucleotide sequence ID" value="XM_019174847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM97"/>
    <dbReference type="GeneID" id="30191918"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="486" mass="54537" checksum="FF578240B1650A53" modified="2017-01-18" version="1">MSQPPSAQLLTLLQSLRTTPTRLIQSPVTQPRRASVAIILRLKPADELVFEGHETEGYDGNVIARDDWGEGLEFEDYMKLPWVNHPNTVPEVLFIRRASPPPTPSTAGNTHHRWASHIAFPGGRQEPDDQSAYYTALRETWEEIGVDLAEKEYLSVGRLDEREVTTSLGKRLLMILSPFVFLQTSPFSPTPELQASEISSVHWVPLTLLVPPFADDRWAKIDIDISSRLSPRNKLVRWCLRNLIGKMKFGCLLLPDDPAAIAKDFDRAEFDESVEGSGSWTNSHDGSQVLRLWGLTLGMTLDLISHHPSAPSTLLTEGSTLTSSSPTIPISEYTPLNEPRTPVTVQSSFEDEWEAARKVLKDETDKNTKAAAAENGKERKRRRGAGPYMTAVFPTFTYPDVNFWIWVFSRRYRQVIRSWESSTIGRSRAADRRINWSGQALATFYTAVRQALLVAIIIRGLCLSAGIVGFSYFVLKSLARSDGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP36</accession>
    <name>A0A1E3JP36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033149.1">
        <property type="nucleotide sequence ID" value="XM_019174770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP36"/>
    <dbReference type="GeneID" id="30191839"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012701076" description="PhoD-like phosphatase metallophosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38783" checksum="89FEA79B9331AD1B" modified="2017-01-18" version="1">MLTLALLSIAGTALASIEGNKAYMTRPLIAFLSWPVTRWEYHDGQLNFPYGVASGDPYPNSVILWTHPVPSTDDFRPVCLEYQVSNSNSSWSELVTSDQVWTTQDVDYSYKVERSWEPRAETDVLLSLRQLRRQRQRLADSLSFAVYSCSNYPFGFFNAYGNAARRDDVDYALHVGDYIYEYQGDGCEDGNTCYRDGRDIDRVPLPNHEILTFDDYRQRYKTYRSDPDLQLLHQKHAWQLIWDHHEVADNTWMSGSADSNDTITGTYYNVSFTQRKANAVKVYFEWLPIRTVETDDSLRIWRSFQFGTLADFYMLNTRQYNRDLTDLYYNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS13</accession>
    <name>A0A1E3JS13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033695.1">
        <property type="nucleotide sequence ID" value="XM_019174643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS13"/>
    <dbReference type="GeneID" id="30191708"/>
    <dbReference type="OrthoDB" id="10304677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="156" mass="16644" checksum="CF9367AE90A826EA" modified="2017-01-18" version="1">MSIKEDSFSNASDRSDIHEEPTPSAGSPTVASNPSLRYVDAPLDSMATEKAATINQRYPTASAEEKTSILNDVMAQVVYERGWDAGSIMMFESTGAGSVVGEKAEGEWRPARTQGWTGDAGLNARVAVLDGYSKPDDENAGDPGADSDDEESFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTZ2</accession>
    <name>A0A1E3JTZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033648.1">
        <property type="nucleotide sequence ID" value="XM_019174596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTZ2"/>
    <dbReference type="GeneID" id="30191660"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="825" mass="91382" checksum="CB50C8099290E047" modified="2017-01-18" version="1">MPKDDPAQRVPLRRGDACQYCRKRRIRCSADKPSCQHCLKSGRECIYDIKKPTSRVQQLEDKVAQLESLLKGTETLDGQEHRGSASEAVPSSLPSSSSLPAMPIAGPSSLPSTTYSMSNHETVDVNLYGGNYPAAPTGLSDGMPGMFPNFGGGAVFGGMEGVPIQGPSQAEKAFDFSTLDPTFMGLVNSFQNSTDLAESFPQPIPTPYEPPPRTYSINQPSQPQASYAPQYTPNPNSLADMAQAGTDINENMAALLEAAAQTKPEQWNLGITSTVGGTGVGTPEPEQGLVGGWFDAGDLPKIARDHLLDVFFSGMRLFGQEFHVPRFMASLSLPPTKRPHPCLLYAMYTMASRLTSSPSIRQLESHFYSLATTHLATATAQADRLMDATRAGTILAAYTYSKAKYHEGWLLTGQAARLAISCGLHHIKGSVWRATKVPPMRADLAGLMRHRSYNLAPPKDAVEHGERIWAFWSIFVTDRCGSIATQWYPSLTDDMVTTPFPRPIHEYELGLVSDADDVSIASIFSPTGSVPRPMRYDYVDLVNLRIRAITILERSSKLMYLTPEAGWDKHLPRHDSNASALFNESMEYLSTPEHGSPYRSSDSPSAKSALGSRSWTKTARIRTPKAYDSVKRALLKIEDDLPEMWRTNWLEWDGKVHTWHFQGARKDLISLHLLLGCSWMFLEDVFAFNVENTAAVNVAKRLTVTVKYLSNQMVNTDLDVFVVTMLAFISKILIRELKRLQSLSPPSPQQIAVIESEVEVVVHALKHFGRRYGSVQAIRAERYRGSTAEEVEFMKEDHDGKQGDEMVWAKERLGGWVGERYGFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWQ4</accession>
    <name>A0A1E3JWQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033878.1">
        <property type="nucleotide sequence ID" value="XM_019174071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWQ4"/>
    <dbReference type="GeneID" id="30191126"/>
    <dbReference type="OrthoDB" id="10283572at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="432" mass="46515" checksum="A47E0BC1B5BF4E72" modified="2017-01-18" version="1">MSAITTSPSTALVGGHYDTNTSPHTKSDFISPDEATTVSRGFDATSRLLSAGGSQYKRIKADVAKHLYSEIFQGDGTGAGFDRAELEAISRQDRETFQQASNAYDELEGLKSQLRAIDQRTGGAVSGGFAEIFVNFDQADRDGPRDGPTPKQVGEYAAQPEGRELAGRPDEIYEGYDLSSIEDELALSSLYNSNGEASDLSTGWDKSLTGPEYKQIQGPPPPRHPEHSEMTALPERSQQQISYHMGEDGLESQPSSRVQRGITAPPNRSKMDFNALKDWYLTRVSRRTGEPKTMFDLNQTVLEPLSVPDFASRAPRAQPRTDRGYAPSAAPSQVSMISGAASNDLDRFFSFGGDATQTIQSALQSGAEGEFAEMETEDGGVVTRGQASGVTADGRKFTMMVSKSVSSTMGGTGRSRAASLFGGPLTAHRSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWX7</accession>
    <name>A0A1E3JWX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034005.1">
        <property type="nucleotide sequence ID" value="XM_019174198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWX7"/>
    <dbReference type="GeneID" id="30191256"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="458"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="61322" checksum="01CABC312FAD2735" modified="2017-01-18" version="1">MFDPHQTAPKKRASVERDFSAVILVGYGESLYPFNQGTNVISKALMPVGNIPIINSVIDWVLASGLLDILIIVPNIFHDQIADHIAEAYSKSTHAKARIDLRKNTEGERDEEENESFDGKDGTARILKRFRNLIKSDFVLLPCDISPPPYLPLKKVLDKHRSTPKAILTSVFYEPIESVKENEEKFLIGLDRTTDELLLIQPMQALDEDFRVRTALLNHHPTLSLTTRLLDAHVYVFRRTFLDLLATRRAKDLGSMKDQVVPWLIKGGWQRGLGEKWAPILDPPTRDPLAEALARSTTAPVSRSLLFHSQSSPSPSVSPYPDTTPTSPSADADMYSSGILPPASSHKFGNTPEWKCQVMVITPPPSPPSADQPGQQKGQQKGQAQGGKGKQDKSRAPPHEPEYLIRANSLAGYWELNRRFIKSLSSATPPFVTKSGSGPSSVRTTVAGEDAGTAPDVSPQAQISPDSVMGEGTRVGEKASIKKCIIGRHCVIGKGAKLNNCVLWDFVTVEENARVENSIVCSNGRIGEKSQVKDCEFGTGFEAKPGAILKGERLIAGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ12</accession>
    <name>A0A1E3JZ12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034126.1">
        <property type="nucleotide sequence ID" value="XM_019173421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190467"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1840" mass="195394" checksum="E6F61F07153F00E0" modified="2017-01-18" version="1">MSKSLTLSLPYSSIWTYDPPSSPVFYTKGLNRSRGESLGKDHPKEKEKDKDWERERASKSKSTSQSPSTIPRASMTSDPIKTKTPSAKAKVLPWVQGVHDSEGSIPDGMFGPYNSRPASMVEQPTTAPRHPFAYTPASRPSLPFAAIANNSNTGAGHQAQSSKGQRPESEAFSRGAGMRDLSGGHVLGGVRVRGDETPAGESGTSPGEGTFGMEGKPGQRTPPPLSKSPLPPTTKPPSPDSPSNTRQAQEQEHHLHKPHHPYPFSPAEALAKQRSAMADARAAALAQLEAAQHNADELLEGQMREVLSMDITQDGGGGGGGEGGQKEKGPRQTFDTTTSVPSFGHIHHQNGMPISTRPSLQTAPDGFFPPFSHAQAQGHTSAPPDVFRIPFGVPTGTHVPRPLMVLRDSSGGAGGLGLGGLGGLAALAGGGGQRRGDERSAYVETVPDVSLLFKEEEVLSPEHTLRTDGRTEGSRSRAVSPAAARTESHLLPSHSQHPTERLLPTQATRAPSSPLVPSPKPASQVPSMATKTTVRGSKTSRAAAKEEKKAAKAASKAGTGRPLAGPGTSDYTQIPPDSYVSTFPGGMLPRNQLQSTHGTSLSMPPPPHSLQVPGSNQTSGNGGGSGTVYTETGVGSVPVPGSGAPPPTFAGTQYTSMAVPNVSQMEAHEHPLVAMSAWGPGPGGLQAQITGQGQGQQAGGYAPSLQPQGTGYAQSQSQGMPSQAAASQQQVQGGFAPSQAPPAPLQSQATGYAQSQVPPQGTTVYSQAPPASLAPQATGYAPSQAHPQGTTVYSQAPPASLHPQGTGYAQSQVPPLGTVYSQAPPTTIHPQATGGLQTQAPSTHALTQAPGGTVYTQDPSTIFPQGLGLDRLAAAFHGQVPMNFGQAIAPGQAYNAVEENHEVQVNHSPLESGQIDESLLSPTLSQPSSLPSTTLSNVKRLIDSSRYHDETLCQLLDAARLNLIGGEAKKALQRAARARVVELKELRERGEEEDRGGETPGFGNGHSHSHLHTFVATEYDESRESRGKERSKEKRRRRSKSRKGRTASGKSDKARTTVAVEEKEEGAPAWAQDIMARLTAFDQRFTALEGQKPTDQPLPLSSRREAYSQFSREVPSGLIDDLIYNGLPSSGPTGGGVDNSQGFPQSAAVAVGSAPTQSQAPPTMDGIGVGVPPGVAQSQRAASGVPSHYSHMPIPNVSAGITPGQHQPSQYAPTQAAPFQYAPTTHQNAPTLAPTQISRQHHPGAGGAMGGPRNASGDLLWGSEVELPKMGTTPKKGFNEGPTINILAPTESGPGTMARTVSGKSIETERLRNGGGMDAVTNDEAVSEHTLPTAALPDPREKDLPPQPAESEQSQPPGSTPDDALTNAQRSVSGTHLASHAPTTTVAGTVPRQMSPPGVGSQYASSWQPDQWPPRLKTKTAGTQPSQARGSPSQYTQHPQSSHIVQGSPSQLRQQAQTSKSVRGSPPPPVPTQASNLTQVGMLDPNMPMWSGHETALGTGTVAGRQGTMYHTAIQTPSSVRPPTAFPTQTSNPTTFPANSTAQPPLLETMTSLQAASNILSNDSPPPSRRDILRITDPLASGPSGGWRPWDLLTQRLYSWALIMEEKSFVRALEDISLGRQVGEFPLSVFMMLAYKRWVRKTLSENPAAPCDKLFVPPNLAIAINAAVHGRQYREAKEILLDLWDCVGQKEPPRIIVALAPLGDEVDEWAAHRYDLSNKHLTSYRVSHLSEIKTDGRSFWWWEVIRQAWPQSNVPTMEELESRGGQRIINEHRAPEYKHENSLYAANISRNLLLGHRPERTHDLTKQREVIWAEMKRLLGKKRNGRLIVDPDAPEHLYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZJ7</accession>
    <name>A0A1E3JZJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034418.1">
        <property type="nucleotide sequence ID" value="XM_019173713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZJ7"/>
    <dbReference type="GeneID" id="30190763"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11460" checksum="2279A677AE3C6004" modified="2017-01-18" version="1">MTLKRRCFRRRSAGDVEVAAEESRRSSIHQTPQTGKRAEKRRSDASRSLVTVVGHYYESNDFIHCGEAFAEFFLVLKHVVFAHSLDVGGNALFQTFLMVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K017</accession>
    <name>A0A1E3K017_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Centromeric protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034540.1">
        <property type="nucleotide sequence ID" value="XM_019173835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190885"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000143">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="169"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="820"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1534"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="518"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1306"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1326"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1477"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1534"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1558"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="258"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1675" mass="183956" checksum="D0E97FECA76830CC" modified="2017-01-18" version="1">MSLTLSRQPSSPSLALGLPPAFPENNIMAPSTSPSKMPRTKSKHKIHRGDVESTDSSDFEEAPKQLVKGTPKRKVVNSVEPTPATGQSKKRGTLAERLAAAAVNKPKVKSSSSVNGGLKASSSATQLSASSTSSTVQTPTMQARTSLIPSTMPVKRTAGPSIGGNPSDKVVVCVRIKPTQSPFATMAYDMTSTSLTLSDDHPKVKQRGGKAGREDTYNYTFDKLLQHPSTTPELYTAKVSPLVDKAMSGFNSTVFAYGQTGSGKSFTMTGIPTELGIIPCAVDGVFDAITADTDRAFLLRVSYVEIYNETLRDLLNFKKGPLKDDEKPVIHTQKGKVYVEPLVEEIVSTPEDVMELLEKGNAQRRIGATDWNERSSRSHCVFTVVIESKPRDKDGDEDIRLSRLNLIDLAGSEKAVSDSERRGEGKHINQSLLALREVINKLTEKQKASHIPYRNSKLTHLLENALGGDSNICVICTMSAEEEHCGETLETLKFAGRCSQVKTHAKKNILPASERAMIRAKDQEIEELRARLLGLTGDSAPPKAGPDADQITDLADSVAAMEARKAKLTAQLAKLNGEILTSELPRHSASSFNLPQTPSKPKRRRISDFSAIMSSGGDRMGLGMGTPKKAADRRAVSNLVGVKEESETSATLGTLDSVHEGSINFEHDIALATLRKNLAHKEEELVLANRNLASALSRASQLSERDERVAALTVELSTALQQLSELQSTLLSTESDLRDQNAQLESARDDLVSNIGDKSSKIDELENKVLELRKSREEMAIEDESRLQEVQKELAGIAGEKAKMQARVELLEKEAVARKGAEEGQKAAEEEVQRIQSELDSLRESHSQAQSSAASSSSKAIEHETTISTLTSQITDLLAAQASRETALNAVKSEHAEITKKRDQAVEDLDSFQKQAMANETKVLSELREEIGKLRKLREDDKVEWEKQKAELEAGFAELKEREDKSKAQLAEALHTLESAAAANKKLESNVAKVDEAKSAAEKERDQAVDNLKEASGRAKIQLEQEIEYRRSLEAQLSSLQQQLDAQRATIENVSQDLQCERESAKELSEKLATAHTDMETQEVRIEKAVDERKDIEARLGEMESALEAGEEEWKARIDKESAKRSKVEGKLVELEKMRQVGNTTEKELIEKLSSLQTQLSADQTVTDDLRKKLEIEVTAKMVAEKKVVELGRQKVTSSAAETDLQKQLENAERRRKEAETKAAEVEKEREVELAGLRAQLDAEKASKADVERKLSEAAEQHVLKLSADGEIRSLLDKETSARKDADSKLADLAKKLESSSSAEKQIQHKLDVESASRQAAEKQLVELSSKLKSVSSNESELGARLDKETASKQAAEKRLADVQRGVETKQASVLVDMKKEIASLRQSLLKAQSDAQSSRDEATAHREKATKLAKDVVELEARQKNEISMTASSVSARLRTLSTPGPWAKDGDMSGPGSKGMKSRGLKGTTTGMGIGERESSMGTMRARDQDEIERLEKVIEVQKEIIDEQREKIERWSKEMEKQREIVRLLTNDHSNTTYSPSPRVPSRTHAKAHSISHSPTESPAGSTPAKAIPSTFTARNLALPSTPLPGTPTPLPMHPSQFNNATARKGRRITIDHDMDLLTETSKVNRAKLLFESPEKNGKALPSTPVREPRESLRVNQAAWSIPRQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K038</accession>
    <name>A0A1E3K038_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034584.1">
        <property type="nucleotide sequence ID" value="XM_019173879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K038"/>
    <dbReference type="GeneID" id="30190929"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22756" checksum="4732E64F5509D350" modified="2017-01-18" version="1">MANNHTDLCLTAENSFLTPGWAAALSNDFLRTKFERLYSQDTQKRDGDSDLFIRYENLNIPKVRFRISGHYQSVDNIRIPIPDVVPMFPLPGTCGFDLIMGRLYLDSTHPLSIALQHCLISVEDVYNKRHHGLEAEGLVVRALEREGRDVESHLQGLDNVENKRVEEEEEEHVKEGGRDEDGDDDEEEDDEVWSWGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K047</accession>
    <name>A0A1E3K047_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034594.1">
        <property type="nucleotide sequence ID" value="XM_019173889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K047"/>
    <dbReference type="GeneID" id="30190939"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="747" mass="81920" checksum="3E41AC2D4B2FFB47" modified="2017-01-18" version="1">MSMAPPRKGENWELRQQLNSEYRDKRADAIKRVIANHTIGKDCSGLFPDVVKNMQTDDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDTADPNPLVRALAIRTMSVLRAEKILDYLASPLSRCLKDENPYVRKTAALCVAKVFDLKPELCVEYGFIETLRDLIGDGNPMVVANAVAALGDIHEASLSLPQTPPSNDDEDDAPSRPNQSLFIIDSTTLTKLLVALNECSEWGRIAILTTLARYKTSDEKESEHICERVMPQFQHVNAAVVLGAVKVIMIHMKNVTRQELIQSLIKKMAPPLVTLISSPPEVQWVALRNINLLLQKRPDILANEMRVFFCKYNDPSYVKVEKLEIMVRLASEKNVDTLLGELKEYASEVDVDFVRKAVRAVGQVAIKIDEAAGRCVGVLMELIETRVSYVVQEAVIVMKDIFRKYPHSYEGIIPALCANLEELDEPEAKASLIWIIGEYAEKIENADELLGAFLETFREESYPVQLQTLTAIVKLFLKKPDESQAIVQKVLQAATTDCDSPDVRDRAYIYWRLLSSDPAAAKSVVLSVRPPISLPQTTVAPAILEDLLHEISTLASVYHKPAATFIGKGRLGADDVARRNLDAEDDASREKALQTVVAGQQAENLLDFDDDPAPSNGPSNDLSGLASLSSPPPSGGISNQQIASAAKSTNPLDELMDLFSTAGMSAPAVQPGQPALTPQQSGGGLSGLEGMASPPAATPQPQQQSAQGGQDDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0K4</accession>
    <name>A0A1E3K0K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIRAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034117.1">
        <property type="nucleotide sequence ID" value="XM_019173412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0K4"/>
    <dbReference type="GeneID" id="30190457"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIRAN" evidence="4">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="18058" checksum="44B84E43459D260E" modified="2017-01-18" version="1">MENIDIPGDAPSTIPKCPREGTAIPSSSQVSIPGSQDVEDDPPASQDLKHWEHVGTFRDYVVGVQYYRGLVGEGESVMLRRDPANEYDSNAIQVVNAGGDQVGHLRRGLAMQLASYMDSNKIFVEGRMAEHNLDGFKHYELGLDLSIYRNRAIIPAREADDPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0R1</accession>
    <name>A0A1E3K0R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034177.1">
        <property type="nucleotide sequence ID" value="XM_019173472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0R1"/>
    <dbReference type="GeneID" id="30190519"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="63836" checksum="380BAE7698C651CA" modified="2017-01-18" version="1">MSFLSYDEKKDVSPPPVYPILPAGQEDDVARPEYFVDNDLKFVGEQGGNGAQATYQDAYGAPVEGKNPLGYSVGWWSALFLNVTMLIGTGIYSFPSSLLKNLGSVGLALCYWPIGLLISLAGISVYLEFASYFPSRSGAEVVYLEQAFTKPRYFFPIAFAIQTVILSFVSSNVIVVAQYIFRMTDHSPTDWESKGVGIAVLTACTLPVWLSTNASLRISNTLGVLKIITLLLIIIPGFVALGGGFKAVPEPTANFHNAFEGMSSNGYNLSNALVNIIFSYGGYTNSFNLANEIKNPIKTIKRTANTAVIFVAILYILTNIGYFAVLTKYEITNSTQVTASVFWEKIFGSKAAKGLTILPVLSAASNIVTVIVGHSRMIREIGRQGVLPWPRFWVYTWPFGTPTGALITIYIISFIVVVAAPAGDAFSFIVALSNYPSSFFLALMTVGLFVIRRRRARLNLPPSEYRSWTFVVLFFLASNIFLLVMPWVPPPGGLNGGSYSFFYASSSLTGIGIIATCALYFFVWTRWLPKWGNYQLRQTVVTLPDGAVTHQIIKVKNDEVDAWDVKHDIAGRSLDEREADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K215</accession>
    <name>A0A1E3K215_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034587.1">
        <property type="nucleotide sequence ID" value="XM_019173882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K215"/>
    <dbReference type="GeneID" id="30190932"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="530" mass="57551" checksum="A76DA7784678D7E7" modified="2017-01-18" version="1">MAELQEKPSRIDTNDKKDKSNPDALNEDDAQTNVSSPEDDLVLDGVEPVYAAKAGVLNQAINDIGMGRYQWQLFCVAGFGWAQDNLWLILTSLILSPVANEFNVGQPALLTLSQNVGLCAGAAFWGLGADIFGRKWAFNLTLGVTTVFALAAAGSPNFAMIAVFDAFWSFGVGGNMPVDSALFLEFGNHQYLLTVLASFWAISQLIVTGVAWGLLGEFTCEEDAVTCLKGDNMGWRWLLLSMGGLCGLMWFLRFGCFQMYESPKYFMGKGKDEEAVRIVHEIARRNGKESTLTVEDLKACEIYGSEDQQVETNTKAAFKRKVRSLGGDHVSRLFASKKLAFSSGMIILIWAFIGLAFPLYNNFIPYTLARKGAAYGDGSTYITYRNSCIIAVLGVPGAILGGYLVEINRLGRKGTLSVSAILTGVFIFGSSTALTSNSLLAWNCVYSFFSNIMYAVLCAYTPEIFPTRDRGTGNALAAITNRFMGVMAPIIAMFADLESSAPVYTSGALFIAAGLFTLILPYESRGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K232</accession>
    <name>A0A1E3K232_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair protein Rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01494</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034362.1">
        <property type="nucleotide sequence ID" value="XM_019173657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K232"/>
    <dbReference type="GeneID" id="30190707"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="306"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="732"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="911" mass="100071" checksum="A4394B150AC5F210" modified="2017-01-18" version="1">MENIDIFGGAPSTTPKRPRAGTAIPSSSQVSIPGSQNVEDDPPASQALEHNEHYATFRSDVVGVQYYRGLVGRGEYVMLRREPTNKYDSNAVQVVNAGGNQVGHIPRAVAMNLASLMDRNVISVEGRMAGQNLDGAKHYKMGLDLSIYLNRTMIPALEAELRWVPGRYNPLPPQPIIQSQTGMHGGTGDSGSGLPGGDTAMQDLLQGLSKENVDIKQSDKVMDALTGDVDVSLLPLHPSPPGVLNNQLVVDLLPHQSQALQWMIGRENPKLPAAPEDPAVQFWVRQKGAGGRNDYWLNVATKTPQTETPVLGRGGIIADGMGLGKTLSTIALVLATRGEPVGDKVSQATLIVCPLSVLSNWEKQIQDHVAPKQLTFYTYHGAAKALTAKKLEGYDIVLTTYQTVMAEAGDLLGNPDTPSAKKKKTTTPKGALALAKINWKRVVADEGHQLKNPKAKMTVGFTSLKAERRWVCTGTPIVNSPNDLGSLLSCLHICSPLNDPAYFRALLLRPLSRGDPAAHKLLQAVVSQILLRRTKDSKGADGKKVVELPELEFFKVGVTMDEETRAVYDEVMEHSRTEFEANMRSGEGNPANVLSMLTRMRQICLSLELVPQTFLDDIRKPPQVRDTGSATSIASLSPEKKQELIEKLKAYVADEIECGVCMDETEFAKDPSITDCGHPFCLPCITQVIKTRPTCPMDRHPLAQTSVLQLPPPTQDGDFDPSSQAKSIKSAKIDEVVKYLKLFPHHDKSLVFSQFTSFLDCIGTRFKEEGIKFVRFDGRMPAKERAEVIKKFQEPVKGDDDEDTPRVMLISLKSGAVGLNLTAASNVFLTDPWWQSAIESQAIDRAHRMGQKKKVRVFQLIAENSVESTVLDIQKRKDELVAKAFEKSTKEIKKTKKEARFEDMKEILGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3E2</accession>
    <name>A0A1E3K3E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 39 (Zinc transporter), member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035087.1">
        <property type="nucleotide sequence ID" value="XM_019173361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3E2"/>
    <dbReference type="GeneID" id="30190404"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130728" evidence="7">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="396" mass="41455" checksum="AD62A9988592EF3E" modified="2017-01-18" version="1">MALLGLLLLAVVLVSAEKQEVSDIPEEIAKAMHGGHHGAHEGTSMKKVFATLFPFESPAWNSILATFYISSVPNFILLAVPATLDPTSLNTMISFATGGLLGDVFLHLVPHAFFGEGHGVGEDGVKSVVVEEKRNIVIGGAIFLGFAAFFVLDKTMRVLSSSAGGGGHSHSHSHNHGHTHAQPEESTATSSAIAPSAELRSRNTSTSKEPAQPETAEDDKEKVNPSLKLSAYLNLFGDFTHNITDGLAMAASFYSSPALGAVTTIATFCHEIPHEIADYSILIKSGFTKSQAMGSQFFTAVGAFVGTFLGIWIAETSGVAAATAGGAVSEGQGFFGTTVGGAELVIPMTAGGFLYIASVSVIPELLEESRSGKQALKEYAAMAFGVFCMAVIAWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3G6</accession>
    <name>A0A1E3K3G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035048.1">
        <property type="nucleotide sequence ID" value="XM_019173322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3G6"/>
    <dbReference type="GeneID" id="30190364"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="30834" checksum="55F95E2E0DCB3B05" modified="2017-01-18" version="1">MSTSYTIHVSGLAPETTEDKLHDFFSFCGKLTSVKKSGSEADITFEKLSAMRTSLMLNGGTLDGAHLEVTSASDIEKTPSVLPTTGSTPIGTGLDSEGVSQEDKPKAAIVAEYLAHGYVLGDNIVQKAIDLDHKQGISHRFLNFFNSLDHTVGQKVVGENQTFSGRIQQHAATAVAKGREVDQSKGISARFSEYYSKVFGTPIGQKVVAFYTTTQKQVLDVHEEAKRIAEDKKKTHLATVPADEAGSSLPSSDVKADVASSTTPAAAATSIPTSTAVPTIPISTIPAPPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3J2</accession>
    <name>A0A1E3K3J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035088.1">
        <property type="nucleotide sequence ID" value="XM_019173362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3J2"/>
    <dbReference type="GeneID" id="30190405"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="290" mass="31266" checksum="C889245BB181D7D4" modified="2017-01-18" version="1">MSHAANLTNHNADNYHTNASFVFSAANTAPVLGLLQAKEGEKIIDLGCGTGELTKGLKEVVGEKGVVVGVDSSQDMLDKAASQSPSSIPYIQADIQSASAFAAAHPEYHHAFDAVFTSATLHWCKDSPEGVIELVGWLLKPRGKFAFEFGGFGNVCGIRAALHHAVRARGIDPIPLDPWYFPTPRQYESVLKAADFTPSNVHLAPRPTPLPTSLQGWLTTFARSSFLSSFSDTDAATIMQEAAEISRIDNYWSAKNPGMGVKGQEGQEAQEEGWEVMYVRLRGVAFAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4V2</accession>
    <name>A0A1E3K4V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035014.1">
        <property type="nucleotide sequence ID" value="XM_019173288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4V2"/>
    <dbReference type="GeneID" id="30190329"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="476"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="582"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="723" mass="81611" checksum="BA9ADD484426C949" modified="2017-01-18" version="1">MSPATPSGALEMESDPSVIPPQLAQGIPMLKISSRKIKQVIFKIRNGCILWSSKKDSRVPINDIRDLRLGQPPTDTYNSTRWITVVYVREQQWKVLHMIALTDETYSMWVKALKELVSITLDRQVSDVTPTDPDMIWIRQLWPLGTRAINKAKAEALCAQIGLHINQKLGESSEVCSLALITRILLMIPQETFDMAAFHQLIKASQTRPDIQRLFTSLSSEGPLDLDRVQTFLRDVQRLPVDTIPAIFEKYKTDEGVWNLEALTSFLSSADNTPNIPQDMTHPLQHYFISSSHNTYLVGDQWKGESTVEGYIRVLLAGCRCVEMDVQTGDFEPVVYHRKTLTSSVSVRDICRAIMAYGFVASPYPVIISAEIHCTSEQQTRLAQILKEVFGERLVTTPLAQGFTELPSPEQLKGRILFKAKPPKELKSPRIETFQLAAPPAESPSSTDSDSGFVRLARRLSIQGKAERPNAFSPQLADLLVYTQGVKYQGFSKLNEYLPSHQFSVSEKTAAKIIKEDKGTWVKHNMRHISRVYPKATRLGSGNYDPVDAWSAGCQLVALNWQTLDESTLLNHAMFHGSNGYILKPLALREKIDEQPERYHLTIEVISGQRIPLAPDLYVEATLNGTVARRTKSLSSVTLNPTWDDTLRFELTTKPSLLMLNFLHLEVKNKSLQAQWIRPVGLAPRGYHHLPLYDSLLSRFVFANLFVNIRVEKVQRVESLVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K509</accession>
    <name>A0A1E3K509_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035145.1">
        <property type="nucleotide sequence ID" value="XM_019172203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K509"/>
    <dbReference type="GeneID" id="30189226"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="363" mass="39786" checksum="AF5EFFF5BE861274" modified="2017-01-18" version="1">MTNTHPQFDILGLTVALSPEKLAELKTHFKHVYYYPHDGKEELPKEAAAEVDVWYCSWLGIPEYIKYEDVPNLKLVQLTSAGAALALKSSVLSGKEAQENIIISSASGIHSTAIPQWIIAQIITLYQQLHLQNFNHRTNQVWTRNIPQLPEYHTQGFGRSLYGKTAGLLGYGHIARETARLLKAFNVNVIAANSKGDKRVDDGYIIPGTGDVEGDIPSAYYSTTDKASFKTFLGKSDILIASLPSTPQTQWLLGEEEFALLPPGAIFINVGRGDLVKSETILSALSSSHLSGAALDVTDPEPLPPQHPLYSHPRVVVTAHTSSSMEGLGYNDAGADLLIDNVRRVREGGRERAINEVDVEKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K528</accession>
    <name>A0A1E3K528_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035165.1">
        <property type="nucleotide sequence ID" value="XM_019172223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K528"/>
    <dbReference type="GeneID" id="30189246"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16833" checksum="448F574FE4F262B8" modified="2017-01-18" version="1">MLLQPQNVIRWAPPSDPPTAAWWLLSGMVNLVLKDFYREGQVGLGVEAEVFAKLLGEKDGKLAKAFREIGLHRTCFLLVASFTILALSLDRLLRLSQDHHSVLEYLQNLPQDSLMLPENFMKACEGVRYEEKEYKRTRAAVEKCLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K558</accession>
    <name>A0A1E3K558_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035195.1">
        <property type="nucleotide sequence ID" value="XM_019172253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K558"/>
    <dbReference type="GeneID" id="30189278"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130814" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="29"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="307"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="539"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="800" mass="85183" checksum="3D01D613F5FAC580" modified="2017-01-18" version="1">MIGSSTQWRPLALLVLGLAILLTSGVDARSPHPPPLRRITTTSAHLSILPRKPPPPSKKNGYLSPRFSTPLPPPPPTLKHSDSLILSLDLPDLLPFEVKMLVHPSEYLFHPEAKVSYGQSSFGSERLRQEDWRMYTGSVIAPYYVDRLTALHSISANLPESEKQNILGRASVMVHHSGDLSGHGAVWEGSFEVLGQMYNVMTRDKYDRIKTTEDVAVEGMGEMVVFRQSDMRHDNATSSSCSHDNLHFNDPHHNPLFRPSSPLTPPSLFAPLLDSLWKRDDTAGGMDVSTNYIDSINSTSGCPNTQQIVYMGVALDCTYIASYGSTDAARTQVLNDWNQVSALYKQTFNISIGIIELQVQNLTCPTTAVNGEEWNVGCSNDVTLDERLSRFSAWRGNKGDDGAGLWHLMSACPTDSEVGVAWLGTLCQTDSSTQSGQTVSGTGISTATTTEWSLISHEIGHGFGAIHDCTSGCSLSGSCCPLSRSTCDANSQFIMNPTTSSSETTFSGCTLGNICTNIGNRQVSTSCIQNPGVRSVISLQQCGNGIVEDGEDCDPGGNTTSACCDSSTCRFISNARCDPSNSACCTSSCQYAAANTTCRAAVDPTCDFAETCPGDSADCPEDTTADDGTSCGSNGLACAGGVCTSLNQQCASAGGNMGLTTACRQRDDTSCVVSCQDPNSTNQCVVLQTPLIDGSSCGYAGHCYNSTCEEGSWQDTAAAWYRQNLQISIPVTIVAGLIFLALVVAICRCIARGCTGNRGAAGKKYKGQQVPTMAQYPPPPAPAGRMNGAGVGAGYGQQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5F8</accession>
    <name>A0A1E3K5F8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL Lipase/Acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035265.1">
        <property type="nucleotide sequence ID" value="XM_019172323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5F8"/>
    <dbReference type="GeneID" id="30189353"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="272" mass="30234" checksum="46F8D2613F622409" modified="2017-01-18" version="1">MSVSAYTDTIMLFGDSLTQALSAGSFSQRMSEWYLRRADVVNRGFGGYTSEWAISVFEQVYATQEERKQGKAQNVKLITIWLGANDACLPGTPQHVPVDKYKANLVHLLSLLTSAASPYYSPETKIILITPPPVCTSKWLTSRISKWEFFGKEGEKPDQNRDQAVAKTYAEGCLAVAKEQGVEVVDLWGAIVKAAGGEGDAELDSYLYDGVHLTPPAYAVLFEEVKKVIVTKFPELNPETMPMRMPHWADIDPENPRPAFEKVKKGRLQGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T2</accession>
    <name>A0A1E3K5T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035390.1">
        <property type="nucleotide sequence ID" value="XM_019172448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T2"/>
    <dbReference type="GeneID" id="30189478"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="312" mass="37036" checksum="7E3A0EC37FD5BD67" modified="2017-01-18" version="1">MSAKVYLGRLPPGVQKGDVEDYFRDFRIRDIRLMDTFGFVEFDQPRDAEDAIRDFNGRPLLGTNISVEPTRERRREPFDNRSAPRAAPRQGVRISVTGFTGTTSWQDLKDYGRLGGNNIIYADVDKYNPGKGVIEYPTMEEATEAITRLAGVDINGAPVTLEIMSPDSYERRPTYDRRPPREHYEDRRPPREHYDDRRPPRGYNDRPPVRDSRDYYDRPPRGDPYEDRRPRGDYYNDRREDRYARERSPRRDYPSRDDYTARDSYPAREDYPAREDIPARNDARRRDDDRRHDDRRHDDDRRREDVRPATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5U0</accession>
    <name>A0A1E3K5U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035288.1">
        <property type="nucleotide sequence ID" value="XM_019172346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5U0"/>
    <dbReference type="GeneID" id="30189376"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.270:FF:000008">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="232"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="250"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="751" mass="82589" checksum="99057C8FCB4BC58B" modified="2017-01-18" version="1">MPARILAPPRSAHAQVAAFVDRHRQLLALERSAEEEQTRLLNSKCSPKLLEQRGLAINSLGVSDISIGLGGKSLVELHRPLAYHTSQALPPHTFRSGDPVRIEAHVSSSTSKSKGKKKDNDDEGAVEGVVYRVGPEKVVVAVSETKEIDLPERLRLLKLANSVTFDRMNRTLDHLARLVLPEPDAPPPRAFNFPLIRSLLGMQLPTWSEEVPPTRASLETDGGEKVNDIEWFGENLNDSQKEAIRFCLKAHDIACIHGPPGTGKTHTLVELVYQLLARPVPSSSNSASTSQPPRILICTPSNLALDNLLTRLHALSSLSPYSSLAPPGSILRIGHPTRVHKDLVRETLDWRAANGEQGGLLRDVGKEMQTHLGDLGRKRGEKGAVKGKERGKKWEEVRELRKEYRAREGKVVSTVVNGAQVVLATCHSAGARQLNNMIFDICIIDEATQAVEPVCWVPILKASKLILAGDPQQLPPTIMSKDSVPAVKNVEQAIQSISLGPSLQPPKTLETTLFERLEKLYGAGIKRVLQVQYRMNEHIASFPSETLYESALVSDASVAERTLAHFPGVEGEEEEVKDDLEPTVVFFDTAECEFYERTEGDEDKSVKAAIGEGSKSNANEAEIAAKWARKLVSYGIPPAEIGIVTPYQAQVALISSMLHEEFPEMTIGSVDGLQGQEREAIILSLVRSNVAGEVGFLGEYRRLNVAMTRAKRQLCVIGDSKTVARGSKYLKKWMDWLEAEADMRWAGDEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K659</accession>
    <name>A0A1E3K659_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter, SHS family, lactate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035519.1">
        <property type="nucleotide sequence ID" value="XM_019172577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K659"/>
    <dbReference type="GeneID" id="30189609"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="525" mass="57223" checksum="DD6C7B2E21D886C7" modified="2017-01-18" version="1">MSLDRSISTESDHIPERKRSASIRDQLRGWHANRAGRSFVRCMIPSIRQPVGGEEPETKNPFKQIAAVPPFAWLLFFSGWLAWTVDGYDFFCVSLTLDDLAEQFGVSTSSITTSITLTLLFRSLGAVIIGLCADRYGRKWTLVVNCLFIMVFELGSGFVNTYKQFLAVRSLFGIAMGGIWGTAAATGLENVPPIARGLCSGILQQGYAVGYLLAAVINLTVVETSKYHWRSIYFFGAGFSLLAAIIRACLPESEQFIQGRKEAKEKGISSKQASKTFVRELGNMFRTNWVRWVWGVLLMTFFNFFSHGSQDLFPTYLKTTKGFSGKLASKATIISNCGAVVGGTLAGWCSQFLGRRFAILVCCVWTACWIPLWILPNDFGGLAAGGFFIQSGVQGAWGIVPVYLGEISPPAFRALFGGLTYQLGNMASAGSAQIEATAGKTLKLKGTSTPDYAAVMGILIGVVIGYGIIVVILGPESDGSHFEKARVAIEQGVGEDAPEDLIETRRKQNAKELDLDRKGSLQHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K691</accession>
    <name>A0A1E3K691_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035240.1">
        <property type="nucleotide sequence ID" value="XM_019172298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K691"/>
    <dbReference type="GeneID" id="30189323"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="14"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="56490" checksum="7FD8A0AE6CAD143C" modified="2017-01-18" version="1">MRSIIDDEFAFRVEQEIQRCLAAWQIRGASIIIVQHDSHNILTFGQRDEHSPVTPSTRFALASNSKLITALLLVRALASNSPPLPVNTPIKAILPSFRLANPLAEAECTVEDILSHRTGLPGYDEMFEPGYVMGELVERLATLELSGGFRERHQYNSILFDLAAILVEKLTGQAFDVYAHEQLFQPLGLTSATFYHTPDQGEFAKSFWQRVDQNGEGDEGRWIEYGIERCQGAIGTGRLWMDSNDMAKWTQALPSIPEYAEAVIPRTIAGAAGGLEFPDQTVLYGLAHRASTHRGVLIHEHGGEIPGFLSKVARLPEYNAGFAILCNSDPGGKYLRALVKCRMIEYFASLPRKDWFAVLDAKRQGAFRSFSAVSIRAPFTSDELAVDVSSLVDTWSSPGFATWIIDHHQVVPSLPAEMGSLPFVASLYGSVELIFSPAPSSLLEDGSTNVGKKGERWNGCKAWTSYDTGEVFFGDPFHIEVVDNRMKVVGMTGVGEGLSEEDWPIWFSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K698</accession>
    <name>A0A1E3K698_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035391.1">
        <property type="nucleotide sequence ID" value="XM_019172449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K698"/>
    <dbReference type="GeneID" id="30189479"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="516" mass="56114" checksum="3F856F3AAF355168" modified="2017-01-18" version="1">MIICIAVGYMITKQGIFAPANAKGVSILSLNVALPALIFGSMVSALSVENAPAMGPLVLVAVIYQILGFMFAWLIKELFYVPVDFRYGILVMGTVSNWGNLPTAIVQTMAKSAPFDPDTDTELGVAYIAVFVFIMNLTLFPLGLHKLCAWDFREENLTAGPPLPRRERWRQRLQFIRGVFKKDRPTNSDAGSNKGKVKLSNQSAEHLHNQKRGSRDSEVSSADDEERGEKLGEMVNRARFAGGAEFARKKSRASSFHSMMESTRPIPATAPLDASGIAQPCFSPSGENTNQLLPVCSTHAETYRYHHPVTPAASTRSPTWGQRIKSLAIAIFTPLTLSIILGIICSVITPVKALFVDVDNWSGNGIPYAPDGNPPLSFITDTATFLGGMSIPAGLVLLGASFARLKMPKKWSDLPIAAIVAMTVFKMILLPIFGVFVVQVMRDNTTMYPAKDKMRTFVSILVASTPSSVNQLVITQLYNPLGSADTLSCFLALQYALMPVLSTGLAAIALYITEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6F2</accession>
    <name>A0A1E3K6F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035300.1">
        <property type="nucleotide sequence ID" value="XM_019172358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6F2"/>
    <dbReference type="GeneID" id="30189388"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="170" mass="18247" checksum="3B2D1688CF1187A9" modified="2017-01-18" version="1">MDHVLAPSMTTSDLQNDDLAPCCILHPEDTLLALLHGLDDIVVLSLSPTTLDAAPATIDALPSIADVILGWIPIFFDGGVRKGLDVFRALVLGADIVLLGRAVLWGLAAKGEIGVGLALDIITEEFKLLMALAGVTDVSQMRRSTLALVNPSQIGLDRVEDAEWEDRRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6V8</accession>
    <name>A0A1E3K6V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50956"/>
            <dbReference type="Rhea" id="RHEA-COMP:12849"/>
            <dbReference type="Rhea" id="RHEA-COMP:12851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74894"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:50957"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035449.1">
        <property type="nucleotide sequence ID" value="XM_019172507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6V8"/>
    <dbReference type="GeneID" id="30189538"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000279">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="39466" checksum="B0C9E48A1BEAC45E" modified="2017-01-18" version="1">MPAPTDPAEAIRQTVADKWLKPNGPPVGTTFGGRLLKTEDDVFSQNAWDHAELPSDFKERAEQVMELHRSSPVAQDVRDKYNERPADYWNKFYSQHEDGFFKDRGWLRLEFPELVACSEADAGPKTVLEVGCGAGNTVFPLIQRNENPHLTIFATDYSETAVKVVKANKMYPKADHGLGVMNASVWDITSKPSSPDTADSAATQPPVTYSLPEGIAPGTVDVISVIFVLSALHPREWKQAIHNLYTALKPGGLLLIRDYGRHDLAQLRIKKNRLLDTPNLYIRGDGTRVYFFEKEELEDMLVGAPADGAVDEKKMFEIQQLGEDRRLLVNRKERLTMYRIWMQVKARKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Y2</accession>
    <name>A0A1E3K6Y2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035610.1">
        <property type="nucleotide sequence ID" value="XM_019172668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Y2"/>
    <dbReference type="GeneID" id="30189701"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="404"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="629" mass="70173" checksum="24B042EBB0267DED" modified="2017-01-18" version="1">MSSSNSHLMKTTRRGRPFVKDTHDLFCTLVVSLAFDTHRNFFKVYPNSFTTDDACSNLSSLKFSQSTRAADPKDPTRIITTTTTTTFSMSRDMAKGICQHFLDSRLIENATDLMSGTFKDRGIYMLTPKGLHILERFVSKNGITADHLLKVFASQPITMKLLHLERRSGDDEIIITRGVIEVLFRRFIGREPNLTKLSDDEVITHYYSRFYTKAPPLPVGETLDRSEGIIIRKSDNKDDYHFSSRSAIQWMLDFTSATGVDEAADVMGQFVRYGLITLVSDKSKPKDGNLIVTVKGGGAGGGAGAIMQEAEYRVTERAIYKVTREGMIAAKWHEPTSNASAGVSKPNLHAENPSAASKGRSSHEGHPSVSIKRRNSASDRFRSDFDISGVPGGDNHVKDSHTARLKQILEEPALRSLFREFLRANFCEENLSFWLDVQDFKRRFQTTSSAVAAPGSKSKVSGHQAMEKHQQDLIAMAFVIYNTYLAPASPCELNIDHNLRADLVSYMNQITADKEAGVKGHIEPGIGNTLHASQLQTMVKLYERIQVYIFRLMATDSVPRFCKTERFLALMQQFSDYDKDDTKGFEGKTANLSINPRKAPVEDDDPGSPTRAYLTISQASLPKFLMGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K704</accession>
    <name>A0A1E3K704_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_00041</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035174.1">
        <property type="nucleotide sequence ID" value="XM_019172232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K704"/>
    <dbReference type="GeneID" id="30189256"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="200"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="18">
        <location>
            <begin position="463"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="932" mass="102514" checksum="9F135C3EC337F898" modified="2017-01-18" version="1">MPPKSPSTPRKRRGMKGGKQPIASTPTSPGEQAKQSKQQQKHHHRHVVATAPVHLPLQKAGKLSWTLLGLIFAILPWVFGRLHYALPEPLPPLDADGIPQPSEEVVRSHIQALEDIGYRIVGTPAALAGEQYVLDQVLELVEQCNARNVLNCEWWHQKGDGLHAFEILDHEVLKSYTGISNIILKISAFHPPSYDIHNPKPDKDAILLGAHIDSTFPSPGAADDAIGVGVMLDLARTLIHQNDPFDNSIIFLFNGAEETLQDGSHLYSIEHSTRTQVKAVINLEAAGSKGGALLFQATSGEMIEAYGKVPYPKGTVIAADVFSSGIIMSDTDFGQFEKYLGVSGLDMAIVGHSYFYHTHHDTLSSIQPGSAQHFTSNIHAVVSHLLSPSSPLSSNLPWSPPDKVYFGLFDKVFLYWDMKAADRWYTALAAVSGVLAVRRLKGKGWKIITTASLATISGLAGGFIGPNLLAFTLTKLGRPLLWFTHEHLPTLIYIPTAFLSSLSIHLFFTHFLSPVERTKLEAVHYGVQMLWCSWMMLALQAVKVRSAYLFAGITLFLLIGALGDGAVRVWGKEREGMNFKATYLLPSIGLIAFFVEAITAALDIFTPLTGRMGKSAPAEHIIATLTAACGLGLFPTLTPLFHRLPRQTQRKVVLVLKIWVAGVVGYLGLGWLYDGEHPKRVGLNYNYNHTDQSHIIHIALMDLGPTGTIPSSLHARYALPSSPLIHKDLEDEDHDWDAIYPVSTFLDTYKFELDISGQGFAQGLEGQGKEKEKEKGGWGGVEGVENFEWPEMGWSVKEKGGDGFRDVEITFNFTDLVWPVLSFHAHVLSWSFPEPAPPAEYMQHHIKFANSVDSPLTTLKLRYKVEEPGQEKLGVHWSAFDVSQMNPFTTPHPGGGKPATVVLTDMWDWIGEQWGGDLDLVTGGVVCGVVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K735</accession>
    <name>A0A1E3K735_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035805.1">
        <property type="nucleotide sequence ID" value="XM_019172863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K735"/>
    <dbReference type="GeneID" id="30189902"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="399" mass="43681" checksum="5E784BB61BB42100" modified="2017-01-18" version="1">MVADSAYYDLLGVGVEATEGEIKKAYKKKAMQHHPNPDNPEAHETFQKIGQAYETLSNPNDRATYDQYGPDGPRGGGGGGEYDMDDLFNAMFGGGGGFDGYDDFGGGFGGGSQWSSGGPRRKPAKGRDTTVPYDMSLEEVFKGKKVVMNLERDRICKGCTGSGARAGVKPKECSKCEGKGEVFTDRMLAPGLVGKMKTPCPDCHGAGTKLRDKEKCKKCKGSRVQKEKKRVEFEIEAGVEDGERIALRGEGDEEPDVPAGDVIFLIHHLPHPSFRPQPHSPGSLQILLSIRLSEALLGFSRVLFIHLDGSGVHITSKKGERIIKSGSIWKIEGEGLPIRGSWGKRRGDVYVRFEIEYPDEEWARKQGDGELVELPGKKPDLPIDKEKVVYRQLSAKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K768</accession>
    <name>A0A1E3K768_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035621.1">
        <property type="nucleotide sequence ID" value="XM_019172679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K768"/>
    <dbReference type="GeneID" id="30189712"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="360" mass="37862" checksum="0BD07D1D976856A0" modified="2017-01-18" version="1">MKAFQVSKLAHPNDISAYDSPTRVSAVGNGLTLMAIRSDIPIPKADGSKGQVLLDVNAAALNFFDILQSQGLYQTKPPLPFVLGAEVAGTISKTSPIPEGCPFKPGVDRVFGITQGAYAEHAMAEWKRLMPIPSNLSMAQASTVPLTATTSYLGIVIKGQAKPGEWVLVHGAAGGVGLAACQIAKAVGCKVIAAASTDAKRQFCVDKGGVDEVVDYTKDGWQNEVKRITGGRGVDIVYDPVGLVIPSLKCVAANARILVIGFAGGTIEKIPANLLLLKQASAVGVYWGATTENDPGTATQVTKGVLKLLSTNEIRPVVHSTIYRGPGEVLKGLKDIENRKIWGKGVVVIREEDGALKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7C5</accession>
    <name>A0A1E3K7C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_00167</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035294.1">
        <property type="nucleotide sequence ID" value="XM_019172352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7C5"/>
    <dbReference type="GeneID" id="30189382"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="61"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="397"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO08437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="594" mass="62841" checksum="0BC88E7E1F312AA7" modified="2017-01-18" version="1">MLSRRIAATTSKRGFHASATASKEVIMNRYSRTITQPKAQGASQAMLYATDGVDAPEDFNKAMVGVGSVWYEGNPCNGHILALGQRVKQSLVNSGLIGYQFGTVGVSDGISMGTKGMSYSLQSRDLIADSVESAAGGHWLDGMVVLPGCDKNMPGTLIALGRLNRPGLMVYGGTIKPGSCGGEVLDIVSAFQAYGKYLQDGQTEEAERQRQATIRNSCPGPGACGGMYTANTIASSAEALGMTIPGSSSTPAVYPEKLGECDSVGDVMKNLLEENILPRDIMTRQAFENAMALTMVLGGSTNVVLHLIAIAHSVGVKLTIDDFQAVSDRVPLLADLKPSGKYVMEDIHNIGGTPAVIHHLIKKGIMTGEGLTVTGKTLGENCDRWVEKHGSKWEGQKIIMPTEKPIKETGHIRILRGNLAPGGAVSKITGKEGVRFTGKCRAFDEEELFVKAVESGSIKKGEKTVVVLRYLGPKGGPGMPEMLKPTSLIMGAGLGYDVACLTDGRFSGGSHGFVVGHVVPEAQVGGPIGLVRDGDIISIDAVANTLTVDVSDEEMERRRKEWVAPPLKVTQGALLKYARAVTDASQGCGESDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K847</accession>
    <name>A0A1E3K847_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035259.1">
        <property type="nucleotide sequence ID" value="XM_019172317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K847"/>
    <dbReference type="GeneID" id="30189346"/>
    <dbReference type="OrthoDB" id="4584900at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130825" evidence="2">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="75" mass="8311" checksum="381024C3114F93FE" modified="2017-01-18" version="1">MARLLPFLLILLAFALMICQAAGAPTPTDEKPSLVDRTEHNMSNSQRLRRGMPLRKPGHYFDARLGPRAEPSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8E0</accession>
    <name>A0A1E3K8E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035349.1">
        <property type="nucleotide sequence ID" value="XM_019172407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8E0"/>
    <dbReference type="GeneID" id="30189437"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="46" mass="4950" checksum="315653B49A6357C5" modified="2017-01-18" version="1">MATPTVNVVRWSALLTGITYGVFHQSTLQTKYDEDKASTGSASCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9R7</accession>
    <name>A0A1E3H9R7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08309</name>
        <name evidence="2" type="ORF">L198_08310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000073">
        <property type="protein sequence ID" value="ODN73087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000072">
        <property type="protein sequence ID" value="ODN73094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027743.1">
        <property type="nucleotide sequence ID" value="XM_019180275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027748.1">
        <property type="nucleotide sequence ID" value="XM_019180274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9R7"/>
    <dbReference type="GeneID" id="30197519"/>
    <dbReference type="GeneID" id="30197520"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN73094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="29117" checksum="A9C632CB18F6CB72" modified="2017-01-18" version="1">MNDRCGQTSSSDTHPAVLLPASSPSSHPFAYARVVGLYNANVFVKSKKEDIPKYQLMPIALVEELDLDKEWVWGFEARRLPRVRARPKRVLVYTWIDPSMIIRGCHLIPVVSSGEETEPGPVSSLWMPICGCDTGPGHTGQIFFPHVPCSHKGLEGGEGWRGTPPAPDTDSVLTRVGNEQGRTEEEADEVDHGARDGDDAGEDVDGPDSNDDAMNSEEIDDDQEMWGDDDAMSGQGDDEDNEDDEDDDEGDTMVFFDEGNERDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9W4</accession>
    <name>A0A1E3H9W4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000069">
        <property type="protein sequence ID" value="ODN73103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027754.1">
        <property type="nucleotide sequence ID" value="XM_019180265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9W4"/>
    <dbReference type="GeneID" id="30197510"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="168" mass="18767" checksum="B2421E95CDF7BBBA" modified="2017-01-18" version="1">MVYEAIQGQGIEHDLAYDVLTGGTMMFAGKSRHMVDIDLFPPTTRLVNGDDLGDHFCAYQQSFAVVDTAPEVERAFLMTVGEKWDELQGGKDVVGAEKIGDVFAEYEPEADAQGSGDEDDDIEFIEKKKENKGKKAENVDKAEEKQRERGAGKGKKVVAFWRDFRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBD3</accession>
    <name>A0A1E3HBD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_08273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000063">
        <property type="protein sequence ID" value="ODN73647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027788.1">
        <property type="nucleotide sequence ID" value="XM_019180239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBD3"/>
    <dbReference type="GeneID" id="30197483"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000003">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000347">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="16">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="15">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="14">
        <location>
            <begin position="256"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN73647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="349" mass="38547" checksum="9929858D17A1880D" modified="2017-01-18" version="1">MATNSLHSSTDLYRRLTWQSTVPISIRLAPSSTSPNAPAAITDTYFIQAPRHTYLPLLIREIKQNMVELALGDEDVAKYDVKDWWFEEEEEVGGEGVRSFAGQGACRWHWPIDLIATHSYMSRPRSLPLVAQASLPPASPPILRLVLHLSKPPADKLLMPNDLATCKSQWLNQVKEADFVRWRNTTRVTNLRKVDLEAGWDGIVLDDFESYSKMASKIVPLPIPAPTNQQQPSRPPSTDPSGRATATESTYATRSVPIKLYLPDNAPAIQDVLSPMDENGKPNTLISVLHKLIPLLFPVPPSSFKDPYPLAFPIAQGIVLPAEADIAWVASCVCGADGWVRLGICLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HGV3</accession>
    <name>A0A1E3HGV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027869.1">
        <property type="nucleotide sequence ID" value="XM_019180143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HGV3"/>
    <dbReference type="GeneID" id="30197383"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129200" evidence="1">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="221" mass="23816" checksum="656B07CC5746C305" modified="2017-01-18" version="1">MLFGNALSLLALAGYVSANGLGLGLGVKVNVGVDLGLRLGAPSSVRDQCSNKGDFLSELLGKVFCCSDDNRTDPEDGLTCPKGWSMHKEEKCCIPPTETAPCDCGEGYTYNEKTKKCDKNQGSCPDNQWWHQRTNSCIDNSKPSDPIGDILCPLVGWVLRSDRCEPENEHSPEPSTCPEGHEWNPHSCTCGGGSPSQRALAARHTGILYGANSFKARQLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH05</accession>
    <name>A0A1E3HH05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_08162</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027902.1">
        <property type="nucleotide sequence ID" value="XM_019180133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH05"/>
    <dbReference type="GeneID" id="30197373"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="262"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN75632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="573" mass="63837" checksum="6E5459B66117385E" modified="2017-01-18" version="1">MSAPATDDAQIPPAGTTQTAATPAGAAAAAPAAEGTDAPAGPSKSELKKRAKEAEKAKKAEAVRLRAEEEKKAREAKEAEDHARQNYGKLPLHQSQSRDGQTRLKFQELTDELVNQRVLFRARLHNSRSQSAKLAFVTLRQQTHTLQGLVAVSKDDDPNQVSRQMVKYATLIPSESLVLVEGIVAKADVKSCTVNNYEVKIHKIFTSVEVGDLPFSIDDASRPESDFARMETEDVQFSRVALPTRLDNRTLDLRTPTNQAIFRIQSAVGHFFRSYLTSQNFIEIHTPKLQGAATESGASVFKVQYFNGGAFLAQSPQLAKQMAIAGDLERVFEIGPVFRAEDSNTHRHMTEFMGLDLEMAIEEHYHEAVDVLDNMLKHIFKGLQTEYKHEIEVVKKQHPHEDFMFLDETLRLPFKEGMKLLKEAGATNSDGTPIGEMDDMSTENEKLLGSIIREKYHTDYFILDKFPLSIRPFYTMPDPADPTLSNSYDFFMRGEEILSGAQRVHDAEVLAERMKEVGIDPATMGSYLDAFRLGAPPHAGGGIGLERVVMLFLKLGNIRRASLFPRDPKRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLT9</accession>
    <name>A0A1E3HLT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_08047</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028019.1">
        <property type="nucleotide sequence ID" value="XM_019180020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLT9"/>
    <dbReference type="GeneID" id="30197258"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN77312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="34828" checksum="F7025592FDBA5F9C" modified="2017-01-18" version="1">MGSTIPSITSLLAQYPTSLALLVLLSSILFTMPLWKSKKPAYKPEGKHCYITGGSQGLGKALAESLVKQGAHVTIVARDAKRGEGVVEELKSLAKPAQIIQFISADLSSPTDSDQALLAACIPHKGLAPDYIFLCAGFSQPKYFIENTKAEIKWGMDGVYLVSAYTAHSAISLMVSQNRTGSLTFVSSFLGYTSFAGYSTYSPAKYALRGLADALRSEMLLHDIAVHIFHPCGILSPGYEKEMMTKPDVTRKIEDGDKPITPEESVAALESGLRKGYYQITDNLVADFVRLRANGGVPSNNFVLDCFYLFISSASPLPHLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLV8</accession>
    <name>A0A1E3HLV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028021.1">
        <property type="nucleotide sequence ID" value="XM_019180022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLV8"/>
    <dbReference type="GeneID" id="30197260"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN77314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="47475" checksum="FA0B69F9A31299FE" modified="2017-01-18" version="1">MSYRRDNETRSELLVTNILLDGSFPALSSTCAEGQGSNKDEPLLLRHVDPPLIETRFSIRSFRENARGRKVPVPVPTETEEAMMKYLDTVEASIKSLDKYAEPSKIQWGDSAAAFREETHRVYTRQQNLLRNTMDAVYIEENKRPFTYRVHSTVDEFVDDGGELLGRNDQSMDWTEYEERLERAVTSAQGVDAICAASSPDVLDMVFTTEVIQPTTLLAKTGEGETMEWRVLDPKATVACLLIKDDFPETFGNAPEAYESYCQSIFEAMENVYLRPGTNLELGPATTAEDFVQDTRRYEQSLVRQAAFASADLMSATGRSQQTDVVLPREKGKTNDDDAAQDSQAVNGRRVKVAWVDSSMFDVLTGQPSKEPHYYFNRISKYESSIEEGLDRMRKALGDKGEEENDVMVLPERTVWGTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP15</accession>
    <name>A0A1E3HP15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07990</name>
        <name evidence="3" type="ORF">L198_08022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028024.1">
        <property type="nucleotide sequence ID" value="XM_019179963.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028056.1">
        <property type="nucleotide sequence ID" value="XM_019179995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP15"/>
    <dbReference type="GeneID" id="30197201"/>
    <dbReference type="GeneID" id="30197233"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="39"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="36839" checksum="DF0818E664565E56" modified="2017-01-18" version="1">MTLEGQVWLGQVDSGCQWQVSQVCQFPLKVQGLMKSRLGSGTQISSYYTWSPNPVVPTADDSDIYDVPFSFVPMLWGCTSQSETDAFLEQLAGNFSNVTLTPSRDILGFNEPDHAGQAECTPSQAAQVWVDVLEPLKEKGYRLGSPAVTGGDTGKQWMIDWYSACNGGCNPDFTAVHWYDPVAQDFIEHIQHYHNEYDLPIWVTEYAPQNFSVYNSTTGLYDDQATYIEIQRFMDVTTAYMKSVSWVERWFWFGAMYDMQDVNTLDTLFDESGKESRTGALNDLGVEFAGANGSVVSSYDHSGSDGTLAIEWNRVLVLWVAVNTGLSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPD6</accession>
    <name>A0A1E3HPD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028068.1">
        <property type="nucleotide sequence ID" value="XM_019179946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPD6"/>
    <dbReference type="GeneID" id="30197184"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30035" checksum="4BAABDCD69CD2A4D" modified="2017-01-18" version="1">MPFTHITLNDGRKMPAIAFGTAKIPDAASNISQAIKVGFTHIDTAQNYGTETDVGLAIKSSDLPRQDLWITTKWSNVDDKSPRQSITESLENLGVEYVDLYLIHSPSFQKGRGEIQDWWKEFEALYEEGLAKSIGVSNFTKEQMEELLLHATIKPVVNQIFLHPYNIVTQGPLVASLAEQNIVTEGYSTLMPLTSMPGGPVDKPVEEIAKRLGKTPEQVLLAWSKAKGVVIVTTSCKKDRLESYLEVGDITLSPQDVDAIDEAGKTGFVGVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7Y8</accession>
    <name>A0A1E3I7Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028386.1">
        <property type="nucleotide sequence ID" value="XM_019179618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7Y8"/>
    <dbReference type="GeneID" id="30196839"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="243" mass="26774" checksum="A7E0CD8266F80D4A" modified="2017-01-18" version="1">MPSVVFDVVGTCFSYDNGALALQTRLGPKLAAHGLSSKLLFYAWVCGTERDYSYLSQIKQYKPFFDILANTLTRVLYQAGVPKEELGGFFTQDDVDYIMAEYKKLKPRPGLAEMMATLREGGFEVWCCSDANIDRVKGYFDHAGVEMPLDHILSADMVMAGKPEAAVYKFAREKAGSDKPGEVSVFAASHAWDTAAAKAAGFVTAYTTTYEYDECETIFGKSDLVTPDLISLGKGIVEKWGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAH8</accession>
    <name>A0A1E3IAH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028510.1">
        <property type="nucleotide sequence ID" value="XM_019179472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAH8"/>
    <dbReference type="GeneID" id="30196688"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10926" checksum="0CA8C8543F3E322A" modified="2017-01-18" version="1">MPAIAASAPDYAGYAYAALLALGGIAGGLRKGSVISAVAGVGSGVAAAYGASRVSKNSFDAYPSLIVSSLLLALMSWRLFKTGKFMPAGLVVLLSLVMTVRYYTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICI7</accession>
    <name>A0A1E3ICI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028699.1">
        <property type="nucleotide sequence ID" value="XM_019179343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICI7"/>
    <dbReference type="GeneID" id="30196552"/>
    <dbReference type="OrthoDB" id="2567960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="421"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="670" mass="75448" checksum="959981559C7B0E3F" modified="2017-01-18" version="1">MQPPAPFRFLTTGKSITIPWADHNAFSESLSYAAARIDHHTTIDDGCKNLMIPQFKIAYDQHVLEGMHAGERLRDLNPDLFMTRQHALDWDTGFPQDTIFFYVDSRTTKVYSTIWDGMKCIQRPLGDLQMIEAGDMVMNRVHEDRMIIGKVITPVKSDLCLSFYLELPSGTTFLVLITYPTPIPHFSLPPTTTLAQLYPPGSILAIKSPLIGFNANGGYVIKVNMPHEIEELHPSDPVLRGIKWEAGLEEEAPMGWMGYRKLGKEAMGKKNPLVALRFYSLALSDPAVKATPIKTFTLLLDRAEAYSTLHLHGSAYRNAHRARESVEKNDNIPLTPGQTDRLCFRLARAALGLRLYTTALQALQHASPRSYLSPELKKVRQKVEMRMEEKESGVYDWLTIFRESLETASPAELDIPDYTSPACHVAHIPGSGRGVLATRDITPGELLMVSKAIAPSRFQLDAPKVYINCYDAESRSHVPHMTYMWVYRLLHKIYDDPSVVPVLDGFSSSGKVPPTEQLPQLEDEDARLKLLFAPVPSELSLDAFRQVSKTNAYGGWSIPAKGTGFDKGLNDEAARKCNKEVGVLLHGMPALINHSCWPNMTECWYGDMMVLRASKHMSAGDQLFMSYNRNEPSYTGRRATLLNWDFECSCFCQNWRTPCQCLYSSLRQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICL3</accession>
    <name>A0A1E3ICL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028517.1">
        <property type="nucleotide sequence ID" value="XM_019179479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICL3"/>
    <dbReference type="GeneID" id="30196696"/>
    <dbReference type="OrthoDB" id="10356117at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="215" mass="24470" checksum="64A3DDD68292882D" modified="2017-01-18" version="1">MPVSLLPPAIPSSPNSSSFIILPLPSNLPKYRKAAYANREEYITQFNTAYQKIMRQLDARRQLVEDEGVEEDSDDCSTNEEQEEILTRLSKCVHAMGRVAGREVIGQMCVCWLVEWYVYTARLLYTSVFLNMTPRDRVVLHPTLIDQVYQTVKEAESILADLNEMDLSNLPPSSRRGDKAWNPKALEGVFVRLMRRVDDFYMGGVHVSSTLSGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICW7</accession>
    <name>A0A1E3ICW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028715.1">
        <property type="nucleotide sequence ID" value="XM_019179359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICW7"/>
    <dbReference type="GeneID" id="30196568"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN86338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="470" mass="50132" checksum="5CAFBD51258288E8" modified="2017-01-18" version="1">MSACLDMSERNHGRTHLLSQLTACSRKKKLAKPSQPQTHAAGAAQAGQERRSRKGLALVYEVIEAGEDEDSAPPLSLSYPPSSHPKPAQARPQCFARKVSLGYCRRHSPGLDETTVNGELDLFTDDATWASEAGERGEVDERLQSHLQHYTELSPAIVGTTTYAVVGLLLPLGSGTSTRSPGIPIVEVCAKTDLMDNAAEDVEQALRTVCLAYGAALFDTAPTQPTTYALLKSYLLHRLYTVPPLLNLPPTSPNTVSAPAIIGCTKFPFNHRANVLDRVAVMVPQRMGYLSRYIPKSAGQEPEEDDGEPFEEFLQVLLPSFASPPPQSPSNLTTVTEPSQNFFSRLLDLLMKDPNRDSHQYFRHAPSAISPSNVPSATNPGAGGFNNTAVGPMGGAAEGLSLQACLLKDKFARLGKKDGKAAPGTLAPAMPNEALHNFFQFLLANRSKMGGSAAGGSTKGTSAEGAGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDD6</accession>
    <name>A0A1E3IDD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_07274</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028763.1">
        <property type="nucleotide sequence ID" value="XM_019179282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDD6"/>
    <dbReference type="GeneID" id="30196485"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="277"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="581"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="716" mass="78173" checksum="5FFF4FB3AD8FC48A" modified="2017-01-18" version="1">MGKSVNKKKSQSGLSTPPTLSTTPPNKALYPTISLRSSSPSSIASRENDHAQGSSAPSTQLSARSSLMNVLTKPRHSPMSSISGGEGLMTPEEEYSDLSTVSSYASSIISGTHNKESVGVEEIAKVYEDYLETPFVQTQATIKHSEFGHDNNPNWRWTSQWNPNEAIHAEEEPQPSYMTLLSTYTSYILLIVIGHIRDFFGKYFTPQNYAHLMPQNGYAALNSDFDSFYTRRLKQRLDDCFARPTTGVPGRTVVCYDRVSNDQNNNFHFTGTSTRALNVSSYNYLGFASSTGGCADAVELAIKRYGVASGGVRHDAGTTDLHIQCEKLVAKFMGVESAMIHSMGYATNSTTIPALVGKGCLVISDEFNHASIRTGVRMSGAAMRWFKHNDMKALEKLLREVISQGQPRTHRPWKKILVIVEGLFSMEGSLVPLPILMDLKRRYKFYLYVDEAHSVGAMGPNGRGVCDYFGIDPREIDILMGTVTKSFGAAGGYVAGSKELIDRLRVRSHATAYAESVSPAVLAQIIASMGSIMGIAPPLAAPADDDSDALSIASRPAVYGPAPASLLPPWLTLPPQLLNGTEGRERLRRIAFNARYLSSGLRKLGFIVYGNRDSPIIPLLIYQPGKMGYFSRMMLERVGADKTPIVVVVVAYPATPLITSRVRFCLSASHTKNDIDLILRACDEVGDVLGLKYARQEMSVEEVVGSAEELVAASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDX6</accession>
    <name>A0A1E3IDX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028792.1">
        <property type="nucleotide sequence ID" value="XM_019179175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDX6"/>
    <dbReference type="GeneID" id="30196373"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45164" checksum="C9B925D08BB473A8" modified="2017-01-18" version="1">MSSPIHSFLFSPPPSPPSRGSDQDHNHGLTSLKSLLLPVEFIPRSSSEKGRSPRTPSQSRLGFETLSLPSPRGLSTDSEATPKARRRSVASTTITHQPINVPSSPQVPFPSTIPKPFLRILFLACVVLSSALIMYEFPAMRPHGIARGIASEGGRGFVELMDPLGEEAYYQPPQTQGARMLWGRKSVREESVVMEQLAQEVVAVAAHPKATRPALRARPLPESHKLLALQSYILSSAYNVVPSSVDPSLPLDANTILGIGSHKLGALGGERETAWLKDVEGEWADEVVIWYGGDGASQYPHSVLDIIESTHNSNRHPTFIPVHARSDRETILAIFARLGLPLAQSPIIMIDNKPIVGDLETLEEMKLSGELGRRLTSVGWKHVEKKVGSKPKMAVIKKQPPTDQEEAEEALVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEY8</accession>
    <name>A0A1E3IEY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028903.1">
        <property type="nucleotide sequence ID" value="XM_019179145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEY8"/>
    <dbReference type="GeneID" id="30196342"/>
    <dbReference type="OrthoDB" id="3267163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="96" mass="10603" checksum="0531A19FE116910A" modified="2017-01-18" version="1">MADPLPTSSAEPLLLTPQQKLMIRNLNAAIPNAERVVAWFPWVFNAHAMLICRTVSRFPWQEDGRGAVRAWTKFVFQAGETECHARGTGAVAHGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGH9</accession>
    <name>A0A1E3IGH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029050.1">
        <property type="nucleotide sequence ID" value="XM_019178956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGH9"/>
    <dbReference type="GeneID" id="30196144"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64518">
        <property type="entry name" value="Phase 1 flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="652"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="916"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1052" mass="112510" checksum="59FA52A92D00834A" modified="2017-01-18" version="1">MADTSVTEDITLQTLGDVHSDTDDEHVAEAQADRAGGAEGLVNGDDGKEAANGEAVEHEEAGHGAENGKPEEDAAPVETVQEPETKEEPKKEASGVMKVLKSGVFGGAPKPSPPQSKAATGAAASARLSRPSLAPVKTGPTASKPATSATKPTSASSTAAARPTHASRASVTTRPTASTTTRPSVTRPTGTSSTAAKPEVKPRPTTSASDRTASSSTARPTASLTAGTASRTRPAPSKPSVPTAASARTTTTTATRPTATRPAATSTSTLVSKPEAKPTTTTASRVTRPSTTTTTRQPLTAQRTGTSTTAATRPAATRPAAGRASMAPSTTARAPISGVPPKVRAGSGPSVVAGGAKELTELKGKVGELEKQIEEEKVKYEEKVAGLEQEKLELEEKHVKAIEELKAEIEAATEKAGADDGQLEELKALHETQLKAAEEEKMAIMSEMMSKLQKLGTEYHSVQSQLKSAQAELSSSSSALSTLQTTLESTQSELESLHSSSQTFESSLASLESSKAELEAQLENVEAEKKALDAKLKEGEADAERSLADASGLGGKVQELEEKIKQLENELEKEKEALKAEEAKAQETKATLEAELEALKGDRASHTEALARATSDHAASKEELDEIKIAHEQLSTTYADLLQSSSRHPEDIADLQRQLSEATEKHEALLVDAASHAGASEKTAELEKKVEELEQARKAGQEEVEALRMKLEEVEVLQGLRKEAEEKEKNLNEIISGLEAEIEKSKAEFEQKYNSAFEDAKAAADKEHQKELSFFRTEIATSQGQLQEAHTAEISSLQNAHSTSLSEISVQHQSELTTLELSLQAAAQQVEQDQKRLEDVKEEKEKLEEEVKRLKSEVETVRAEGEVKGKEASGELEVELKRVKGELQHVTDELKGAREMAEMNKSSFHQTLEAIQEQHQEEARESAEKREAQFSEEKKALAEEVEKVKAETVKLRSDLEDERVEKNTALAKLSEKVATPPTSPHAELPSSPSITRLHEAHNAKVTQLENEIGRLKALLSKTPAGAAAVAAGDRGDVGEESMEFTDDETMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM3</accession>
    <name>A0A1E3IGM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029090.1">
        <property type="nucleotide sequence ID" value="XM_019178996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM3"/>
    <dbReference type="GeneID" id="30196188"/>
    <dbReference type="OrthoDB" id="2573751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="462" mass="53120" checksum="355AA701F0A891A9" modified="2017-01-18" version="1">MCHETPTSQFIGTLVTTIGTFYFIYHIWAYDKGKCLKFTKRTAFRWLIVWMFILSMLLFEAWGIILTYVKYQEWYMVHNGDIIPVPFSAWSDSRQFLVRSAYQILSIAWLLVLAIHSEETLYWAYLIGAIRGRNTKSWYRSVHFKVWIACCIFVAGVVPGVANIETQNLTTMEDNIFLVGSISAFILFIGSIWLLFVFPKFIQESRRQGAALDVIARLQYFKELNSVRTLFRLLYCISILTLAIDGRTERKVVNSNHFWLDCFYISGLFFVFTSNSLSLMILLPRNMADEAGFTQAQQVFVRQNVRQRDLRTRGRGQERELELPSTSTIDRKFSPYTPPPTDDIESDAIHLTQLPSPRAAPHRGSQPWQALGEALNIEQQDPEMGYNDRVGETSKASISASDFDKPFAMNRGERLLRDGENIEQPTLLNHFRSPADFTDPPTPRDLNIVVVTDTVEVEEKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHM0</accession>
    <name>A0A1E3IHM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029165.1">
        <property type="nucleotide sequence ID" value="XM_019178888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHM0"/>
    <dbReference type="GeneID" id="30196070"/>
    <dbReference type="OrthoDB" id="10379958at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="100" mass="11178" checksum="D0F0E55274445381" modified="2017-01-18" version="1">MNMTQQEDPEAPQDVRQSQMSKTSTVEGDFGGDVGSMMSYPLASSSEEDPEPQPYEEDSLAPLVDKREEDASYKARWGARTEDGTNHKGLLFSSAHRYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHM3</accession>
    <name>A0A1E3IHM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029167.1">
        <property type="nucleotide sequence ID" value="XM_019178890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHM3"/>
    <dbReference type="GeneID" id="30196072"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="6">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="9796" checksum="9AC78582320F3DA6" modified="2017-01-18" version="1">MSKPASAAKPVSRAPETVHPAVLGKLITFAVLMAVVPIGTYFGSLNYIWEGSTTFSAISAIVAANLILVGYVVLAFKEDLGDDKKSVGEKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHQ2</accession>
    <name>A0A1E3IHQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029190.1">
        <property type="nucleotide sequence ID" value="XM_019178913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHQ2"/>
    <dbReference type="GeneID" id="30196097"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25154" checksum="904793C42889AFBA" modified="2017-01-18" version="1">MSTMIDDVDGRIGYVGTSWSTNHTGKPHGLEEGDHTLKISNENSRNVDEYPTYIWLDIDAVSVNGELKSATTISTSSSSGSETATSSEVSSSSSSVATSAAVSSAIISQTASASGQVTSTSSSSIYRQETSSKTLSSSKISSPTSPLSSTSVNMAQSFDPLQSTGTPATQYISTTSGNQPGTSDEGPTTHKTTTVAVSATVIAVALIVIITISGLWFWKRRRRRFQAEEEDYLQPSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJH1</accession>
    <name>A0A1E3IJH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029174.1">
        <property type="nucleotide sequence ID" value="XM_019178897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJH1"/>
    <dbReference type="GeneID" id="30196081"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41015" checksum="2925E583AD53D814" modified="2017-01-18" version="1">MPIQSPAFPPEPTLDSIPNFDPEKFQPPAWAKTQSFQWGTDPSGKAPNGVSKLDLSDDESDGDEDDDFEDAQSSFDLHAGDEVLGINPEEAMFTIDELRELLSRATQLKLEGNSLYTSKPPKYEEAVQAYQRAIEHLPLFPSKEEEDSEVEDEDTGERIKKTKEGKEKEEKEKEAPPAVPASSGLQEISEEEAILISKQEDEGAPRQEEDDRPEEEKEREKVENEIKECTKACNGNLAACFIALKQDEKAVKACTEAIKIDPNYTKGLHRRATSNERIGSLTALSSAKEDYTLLLTLLPPSSPLLPSIRRSLVTLPPKIQKQEKEQYDEMMGKLKSLGNSLLGNFGLTTDNFKFEEQPGGGYSMNFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK39</accession>
    <name>A0A1E3IK39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029139.1">
        <property type="nucleotide sequence ID" value="XM_019178862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK39"/>
    <dbReference type="GeneID" id="30196038"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF351">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE PVG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="425" mass="48527" checksum="51172CF72D70CED5" modified="2017-01-18" version="1">MLLHPPHPHRPHTPRSPSSHRFHFPTRRRPLLFLLCALAFLFAPVVYSAHSFLGTYKNFPRHQQYNLLLAKSPAWAHPLVDALKGLPETKGMPRPNMVHGLREGRSMEEYSAPRLSLPVEGLDGELTSPAVLMLHIFSMPSPASRERRELIRSIDYFSAIPPPYRHLVEIKFIMGRYSPGHALYDDNESREIEAEQKREKDLFILEDLEAGDNMNLGKTWEWLRQVGKEGGREAWWVMKCDDDTFPILPNLLPYLLAHSPGAPSYVGTSFGRWPGYHFYFEGMMYGFSWPVVKALAAANVSREDRNREWDEDAHMGYLMFSLPPSSSAPSDCARTPASASSAIDPCTGLHRLDLSTRLGNYRANPLIALPIPGRRGSVGVHQLKNGAQFKNVVDEVKESWEERGLEWRWRVPRELESVAEWDVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKV2</accession>
    <name>A0A1E3IKV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029433.1">
        <property type="nucleotide sequence ID" value="XM_019178526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKV2"/>
    <dbReference type="GeneID" id="30195679"/>
    <dbReference type="OrthoDB" id="2575738at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25940" checksum="41F82AF0FDD2D41D" modified="2017-01-18" version="1">MYPTRSAPTPPRGDRGDRRETLPANHPFATPFNPFSYHTPYHYNCSSSSLSSSAYTPSASTPVSTPSRRAPQSPTASLAQPLSPARSTYPPSISTTSGRRRVDEFGRGRSMTNPAPAPAPVYATLPTELSLFDARPRQTLLQDVEYILGKKMHFPFLARYSSSSSSASSSAKNEKKAKKEAEKEKKTRRRLTKERAYDEDWAMWAGMDGFMDSQVVVVEEKKSKRGVREGNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM17</accession>
    <name>A0A1E3IM17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029548.1">
        <property type="nucleotide sequence ID" value="XM_019178392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM17"/>
    <dbReference type="GeneID" id="30195538"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="128"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN89639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="394" mass="42562" checksum="8C9CFAD3BED9F01B" modified="2017-01-18" version="1">MATNGNGPAAALAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAEDPFSKVACETAAKTGMIMVFGEITTRAKLDYQKIIRDTIKQIGYDSSEKGFDYKTCNVLVAIEQQSPDIAQGLEHGGLEAIGAGDQGIMFGYASDETPEMMPLTIMLAHKLNAALAAARRDGTLGWLRPDCKTQVTIEYKKGEDGAMIPLRVDTVVISTQHAEEISTEDLRTEILEKIIKKVIPANLLDDKVVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDWSKVDRSAAYTARWIAKSLVAAGLARRALVQLSYAIGVAEPLSIFVDSYGSSKKTDAELVDIIRQNFDLRPGLIVQALDLQKPQYLKTAAYGHFGNPNYSWEKPKQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INH3</accession>
    <name>A0A1E3INH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">L198_06171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029675.1">
        <property type="nucleotide sequence ID" value="XM_019178237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INH3"/>
    <dbReference type="GeneID" id="30195383"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="236"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="465" mass="52720" checksum="66C73E9BDC745301" modified="2017-01-18" version="1">MAQYDLTQKLIPNLDRHLAIPLLTHLADTHIYPQEQLARAQYDLTKSTNMVDWVQQLHSQIGDAEAVDFDKLKTEATAKYNELQEKAQPVTSVIENPEAVAKLRSGGDKERNLELLRTEYKIDNDQINALYHFGQYKYSLGEYGAAADLLYQFLILSPSYDLNVSAQWGKLASNILVGDWESALAQLRDVRDTIDNSQGTSLSKPTAQLQARTWLLHWSLFVFFNLDLQEGQQGLLDMFLSPAYLNTIQTSCPYLLRYLVAAAIITRRSTKSSAPSRSSRDHIKELTKIVDMEEYQYSDPITAFLKDLFVDFNLDQAQERLTVAEEVVRQDFFLSGFVDEFVENARLLISEVYCRIHRRIDIRQLSKTLNMSVEDGEKWIVNLIRDSRMGVEAKIDLKENMLHITRPHPSATASLIDVTRGLAFRSQAVQFAIQSSVGGETVQRERGDRGAKGGRGKPRGQEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INQ4</accession>
    <name>A0A1E3INQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029759.1">
        <property type="nucleotide sequence ID" value="XM_019178321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INQ4"/>
    <dbReference type="GeneID" id="30195467"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN90237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="341" mass="37164" checksum="4B0CC4A492CF6EF5" modified="2017-01-18" version="1">MPLPDAKRHKPNSKPSLPTPAPPSSLGSALKNKASMDSRPGPDYERGIEYWDNVEASVDGVLGGFGTGPVPHIEQLSSRLLLLSLLPSLSPFPSPLTPAPLPPLPVHRRTALDVGAGIGRVTRTVLAPLFDDVVLVEPVGKFVGEAYRSASDGEWRDLPLPVHALPPKPVEREGNELQVESYAEAHRQASEAKGGRGKRVRFIQGGLQLLDPRSPGKNGVELGVVGQKRGGGEGLDGEEVVYDVIWCQWCHMNHDDLVSFLQRSRAALRSPDSYIFVKENCCDEGANGEPQEFMDEEDSSLTRSSGKWVEAFKDAGLRVVKEEVQEGMPEELFVVKTWALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQA1</accession>
    <name>A0A1E3IQA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029864.1">
        <property type="nucleotide sequence ID" value="XM_019178145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQA1"/>
    <dbReference type="GeneID" id="30195290"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="258" mass="27450" checksum="D040FAB38F991FDE" modified="2017-01-18" version="1">MSPVIILTGASRGLGLSVLRILLDTHNARVATLSRSLTPELEAAAKEYPGRVHPVQGDAGKPEDNARVVKEAVEKWGQLDGLIVNAGSIDPVGKLGSVSLDALTPYIQMNLLASIYLIQPALPHLRESKGRIVLVSSGASTTGYQAWGLYSMAKAGMNSLARTLASEEKESGVSTFAVRPGVVNVPNISQMQLFLRTHGPGEMSDTDMAKFQGAYEKGELLAPEQPGSVLAGLAVKGPAELSGEYINWADERLKHLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS05</accession>
    <name>A0A1E3IS05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029978.1">
        <property type="nucleotide sequence ID" value="XM_019177939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS05"/>
    <dbReference type="GeneID" id="30195075"/>
    <dbReference type="OrthoDB" id="10291423at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38235" checksum="75C6F83CEDCE21D4" modified="2017-01-18" version="1">MPQTRQARVSAHPDTGLNLATIFPSEICQLILEYLLLLAQSDNNLSLRLMYTCNDLLNTVSPYLYKRVTLHAGNADAFFYGLADGKMKRGEVKGWQMKNEGRLEGKSVVARRLIWLSMVRRVEIMDSPALVSCVTAVKALLKRPFPTRPTDLLSLFFWRAHESNVHEKPVLRISTSVSPPTSMIHGRSRFKKWQQLARLPTLELDLMGPGDVHFYHNIVLQRELSRRAENVIIKNLAHQTLRRIELLSGCPLKSILVIMENGGDDHRKLLEDFAEYFAARGHTNSVLVTIKGYQYQANESSFEIAKLMKEAYVARRAALSYWSHSNVGRGVDFEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISB3</accession>
    <name>A0A1E3ISB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029908.1">
        <property type="nucleotide sequence ID" value="XM_019178189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISB3"/>
    <dbReference type="GeneID" id="30195335"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18184" checksum="ACFAA5AC38E8E9B7" modified="2017-01-18" version="1">MASKDLFKPQWSTSLSLSSTNKPLIITSCTLVTGIPNSHEWSPSLVPPMAASERLTLFLSSAGIHVVQVYKLTLETIHLKGGDILHASHESGVLFSTVASTVAKRLNIKAKSITKQEAEEAYTWGVQMMMMDCRTSSELTRAWLGWKPEGVGFGWYFGDDCVYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITP6</accession>
    <name>A0A1E3ITP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030137.1">
        <property type="nucleotide sequence ID" value="XM_019177753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITP6"/>
    <dbReference type="GeneID" id="30194887"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7438" checksum="FA291EF8ED89D95C" modified="2017-01-18" version="1">MALSLRGDFWGGSADTSTVLSFQISRDVMNAREIFAGQQTYYVAVAPGVDLALMAAMCICLDEMKNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU21</accession>
    <name>A0A1E3IU21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030182.1">
        <property type="nucleotide sequence ID" value="XM_019177798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU21"/>
    <dbReference type="GeneID" id="30194932"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1199" mass="127111" checksum="D8346E13C90C84D6" modified="2017-01-18" version="1">MSNRNPSANYQQGGQPPLPGQNAYGQTPEQAAAHAAAWAAYYQSQGMTAPQAHSAPTTPAQAPPAGAPAAQNPYANYGYGAGAQHNKPQPPAAGPSQQSYRPPASNQAFATASTQPSLGYPQQQAYPAQPQYPQVGYQPGRPPYQQPAPPAQQPYAWQAGQQPQIQPGQPAYRPPAQPQQSYPSYAAQPAGPYYPPAQPQPAPYTPPQPSVQSPYRPPMGGPNMSSPMQSQPTQFRPPALLGNQGRPPRPPMNNQPGGGGGGFPPAKRPRFDGPGGGGNKMTQGRPPNNGPQGPPIGQRNVSRPNLPINRPPIHLGAGPPLASGPGGPSGVFVPPSGPGQPKAGPMRGNDSRRGRGGMMNAPRAPATMRRPDGSFAPSAFSKGVAPGAGKNLFDKRGNKKIGGAVQGKDTVKATMTDWRIVGIEMKGLGWAWGIVDGQKAEAESEVKVEGQEPVVNTNGEAQAKVELTEAEPAKPIESASALIPAVESSESAPVKSEPSLEPQTETSLASKAESEAAIAAAVAEESEKEKRGEKRKAKSPDTDEHHSAKRSVPFKPTTSVTADLALPPSASAATTPQQVSQSTSESPVRTTDDIAKDLLAKYENNSNRLRIYFDSPPELDRAPKVKKTPVKDKEGQEGRGNKRFRSVSVSASVVEEKERDEAQGEEELSVEAAVPAQEQNETEQGDDQAQEDVDRSLGLGENVLATSNINDTANGSAAVATPDIHNTADLQASEEQPIAELLPEHVEYPAPLAEETHAKVEAKEEVGDGDVSMRTEKGAGLADSTAVDPLQAEMVEGSLPGTSGVNGDSMTPEPVEKSAADAAESTESQNEGKSKTNEEVEQSADDKEHGIDEEDKAAKDAKDVSEAAVAAAALAESATNAASAYKSRARRHSSLSTSSHAPAERHLKFANAASPGVSWNRLSVVWEQSTRRLCFDAEVVEKVRIWRQEGKIEVELKEESAGEWKGLPKGIMMELYSPSEQRFLPYTSPSDDPSVPPLHLISSTLANTNSPVVVTVHLNTKNALSEPKWLKSNQADAWLFEQFESRKGVDAGWRGKLEVMDPDPAPTLPGILDGWASSCTLGTPSSRRAFTSFLSSSPDDLLEILLRLGRGDRNPTLGSSSSPSFGPLATLIRPDSPFANHQTHVSLAILAMYRLTTDMAEKAGEKKEAVEEKVGDIIRSLPGALVAKSLDGLFREWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU67</accession>
    <name>A0A1E3IU67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030271.1">
        <property type="nucleotide sequence ID" value="XM_019177887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU67"/>
    <dbReference type="GeneID" id="30195022"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="514" mass="57019" checksum="BBC5FDF12AAD4CB3" modified="2017-01-18" version="1">MASQAVPVPEVLDREKVQALERVESARSNVLEDLGRGEGISYDDLPIIEVSPEENRRVLRKLDCLLLPLTMIAYTLQYVDRSAMSYAAVFDFRTDLHLVGQQYSWLGSVFFLGYLAFEFPGSYILQRLPLSKTMGASIIIWGGLLMCMAAPRTFGGAAAVRTLLGCSESLVTPGFVLIISRFYKREEQPLRVGLWYCCNGLGSFIGALVSYGMGHIHVSNIPSWAWIFIVNGGFTVLFGIVFILLCPENPQNCRILTPHEKRIALERVRANKSSLGSKQFKWYQVKEALCPWICPQGWAYVFITLSLSLPNGGIGNFLHLILQSYGYSSFQTILMGLPQAAMQIVFPLTGAIIARKVPNSRLYVLMAYMLPSLIGVIIQYKTRQSGALLFGYYILGSYVASLGVVFGAPGANVVGYTKKVVVGAMVFIAYALGNVCGQFFWKATETPAYRSGMLACIVCFTATIPMAGALRLYYVYENRRRDRLQAEKGDTGEIEVGNFADMTDVENPSFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVV9</accession>
    <name>A0A1E3IVV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucoamylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030315.1">
        <property type="nucleotide sequence ID" value="XM_019177564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194695"/>
    <dbReference type="OrthoDB" id="2564946at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1442" mass="156122" checksum="8ACA15BEEDB44694" modified="2017-01-18" version="1">MGILSRIRQRSSSIHHDTSSRVSSSPAPHSPSASNLLSTPQTPGTPGTSYNPSSPAAASISSKKSRRPWKKREESEDVIGTKSSWGRKSVGKDLEKEKETEKGGDESIGGDSQYADFTPPPVPALSLPALGSKEGYQSSPLLNKTPSSTGDQEKGKSRTNSGVFKQDGGLLGKLNFERGDRERKVSNSSFILKVEPELKPSPPRRSSVPGTPSEEGESLVVIDSRDLSPEKDEKTPESKHPLSTSVMTHDSQQEEDPMEVLESAEKKHKFWKSKGKVNRHSRVMSESQIERPESPSPVKLPTSSTADNLSSQARRSSESTRPARPPPLRRPSSSFLANPFNRSVSRAGKRSPATDEGTFQLRGFRHVSGMSDVESAGKLEGYLSHAKRESVLALVKSTTSVDDSIPSHSPSAYSAPRHSSYVPLTRPPSAAPSLVSLDDVLTSSNRVSVGAFRKGLRRPSAQLTSTMSDVGHGASRYDEDDDDVPLAMRQVSQPVIRPKSSQSLSSMRGLGLTNVGGIAVPNEIETVAQVAPEPGHQEVSGREIDRTESPALSFQVRPRTRNRTSSGFVVKGRSPKSPPESLAKSPADSYFPSMANASDSLRASPVQTRVSSPANGESKSVTPLPRSPAEASEEVYSTPPTAARPVSLHFLKPKPDFGEHAFPSPLDTARQPSQYLSRSQESQSALRSPPPPEPLGLPEPGQVSPTLSTLNLPLPPDQMPDTPPKGPVPLHQLSLRQDSGGPQATSPGTPKKRLSLLEEPMRYLSGLWTSPGAGEDGFDPVLAANSLRIFGGDEVQSPTTADDKDMAFVDRQASPTPVSAPAPIAERVRCPLSERLAGVAALSASGSSGNLAKPEFEKLKTGDDMLQPQRDMDDAKSPASDDTATPVYRPSPRPFSSFMKPSTSKRGENEESGSETEGERPGPSVQESRRVQSLSLRQSTRRAPGGPRHPNRSSRIASMPITTSQMARKESIARNIHIGDSDDDDKPLYTVKRRMPRSSLAAGKSPVYGQSDLPTPPTSIANASLKSASPPERRRPLIDMAPVVPITPRSIGESSVESASISNRPPDRSQTSTPASGQLPSPVKAQVRFDSPAKRPANPRRTTGGSDKGSRKGESGVRRSNSREALQNGQERDRRERRRSETGSRHPSPYDPPVQAQMGTQPMPDMQQTSQEAYLAWQKHQWQMQYLAAAYRASEDEWERQSAVSGSTNQGPSSQFSPYSMPPMPMFNPNMNMMNTGMPMGYPGFPQMPQQMPPQMFNPFFGMGQPQHMQQGNGGGYAYGKGAQSVFGGEFGPPSNMPSQQRQMNEAIRTSSIDQNISPPRKSHNDQRAKTRSTSALGVRRPSATEPSPLKDRLAQHPSGVFLGLLAEREKVELREQMERSAHENLEKQRRVSKEGKSSEPRRNTQSRVSPPSSWSRRSGEWSSGEHGASSRPNGGRASMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J034</accession>
    <name>A0A1E3J034_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030774.1">
        <property type="nucleotide sequence ID" value="XM_019177193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J034"/>
    <dbReference type="GeneID" id="30194311"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="54"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN94243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="41713" checksum="156EFC751CA79172" modified="2017-01-18" version="1">MALTKTPKKKISPLPKPTRRLLCLGIEGSANKLGCGIISHQPSPADTGATTVTVLSNVRHTYITPPGEGFLPSDTARHHREWVVKVVEEAVRKAGVRMSDLDCIAFTKGPGMGTPLQVGALTARTLSLLHNIPLVGVNHCVGHIEMGRQITSSHNPIVLYVSGGNTQVIAYSQQRYRIFGETLDIAIGNCLDRFARVIGLRNDPSPGYNIEKEAKKGHRLAPLPYGTKGMDISLAGILQSVEAYTKDKRYRTWDQVPVRDSPDTPSNEDIITPYDLCFSLQETTFAMLVEITERAMAHVGAKDVLIVGGVGCNMRLQEMMGIMASERNGRVFATDESFCIDNGIMIAQAGLLAHRMGISMPLEKTGVTQRFRTDAVHVGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J050</accession>
    <name>A0A1E3J050_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030791.1">
        <property type="nucleotide sequence ID" value="XM_019177210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194329"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1579" mass="174619" checksum="ACFF1E68EF410044" modified="2017-01-18" version="1">MAPLTKEELWSTGQDEDVEVNQRALIDKILARYSGEHTIFRELLQNSDDAGAQHVQVKFYSQEGSDALKNGETSSRLPNAKSDLMSSYVVSNDGIPFRDEDWKRLKKIAEGNPDEEKIGAFGVGFYSLFSVCDGPFVESGDKWMAFYWKDGKDQLLARSGKLPTPPSAEPSLSGNSWTNFTMTLREPSLLEGPLDLARFFVTSITFMRTVKKIDILVDGVKVFEVQKNIKSANRVDKKGLNTTSSGGMMTVQNVDSTGMTISVKIMKWLADTGFTPPPMSNPFTQIAKPARGLASMISTSFFGRYTAASPTPPSPAPPPPPAEEPTKSTTLLRDIQIFQANIKVSVSPAFGRELERATKKPAPGKMTASIVYSRDEDNDTKVEDGRDPSADEAGVFSGLCPKLGSSSSARVFIGQPTGQTTGIGGHLAARFIPTVERESIDLVDRHVSHWNRQLLWVGGYLCRLIYELEMHALATAWAKTTDTDGPSRAKLSARALHTIKFFTFKATTPAAAVGQEMEAAFYNCAQNNHTLPILSSDGIFPVKEVRMPNDPIAKFLSELPVITQSMLEQASSFIRRLQAQKLLVDITYDDVVNQLGKRPLTEKELMECLKWWQDLASNDNFNVSLRSRLLDAAIVMLDNGKVLPLSLVETFIRPHSGTIPPDMPIPQHTIPYGITKDLRANSIHKVFGWTELNLLQYVTFLLNTPMSAHQGSDPATDLRISPEFAERVLGLISRAWTNLPSNIQSGIALELKDVPCIPTKAGFKPPREAYFEKNLLFEDLPIISLPKNTAIKGNMEKMLLAIGVRKTVDLQLVFSRLIGGGTWGCLDLMKYLVSVKDTLSDDEIKRLKQTAAFPLQRERLPSKEGEGSAPPALVRQKPWQLYEPIDAFKEMGLPLLDWGDAKWRSNSEEAKMLFMLGLNRYPSKEVLLKIMGGPAPANEKALDYLLANFSNHYSDFRSDAFPDVAFLPATKGGSRVFVKPGEAFSNPDCAILGFAVAIPKIASPENASKLGVRRDPPMGQLVIALVNNVPMDIPTATRTFEYMSAYVNQTAPSFLADTHLIPVKTASDIRLHKPSQVYFHSKERSDNVYASAFTFVDFGDKANVFLQYCGVRREPSVQDIARLFMANSDDMLRQAGSPEKYLEQIRLLATNWSRLDSQTKSSMRSAKFLLASQLVDVKKKSQSLFGQTTEQGDEYEREWVLARAGEIVINDNIVFSQYFGPFILAAPEEALLENFYSVLGSQQLSSFVRTKHVSTPVSSQAASAQSIPLRRHVLERLTIFLTDRRKLASYSIDSLTKDGNFQVEECQSLKVQRTYKNGKVEKTHTESLYAIAAPGRTRGSIVLTVSLSAQKDDYDIASALCEILFKTQKADDALLLYSILTTPLMALRKRGINVDRILNQQKEEKIRLQAELRERDIMAAEKAAENTKTLGNRQSLESTIGSETSEKKGLFGRFGRGSASKDKEELRMPGGMPGIGTGSGLESLPQSKVLDELRHGLGGRHASGAEGYSRPGTYAPDQKQTARPTDLSDIRATVKKAMDASRPETATRIQDSRKAVNNVSEAQGDYCDTTAEVSLKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J094</accession>
    <name>A0A1E3J094_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030828.1">
        <property type="nucleotide sequence ID" value="XM_019177247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J094"/>
    <dbReference type="GeneID" id="30194366"/>
    <dbReference type="OrthoDB" id="2572952at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="132" mass="12818" checksum="FC4E579E844CCD7A" modified="2017-01-18" version="1">MSCGCSSQQTPNCCGTAETQSKCSCPPGNCQCESCPKSSKTEASGACNCGEEKKEKAQTCGCNGSGAACTCPPGQCACANCGEKEVKTQTCGCGGEGAACTCAPGQCGCASCPVQAKEAPVSKPTTCGVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0D8</accession>
    <name>A0A1E3J0D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030835.1">
        <property type="nucleotide sequence ID" value="XM_019177254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0D8"/>
    <dbReference type="GeneID" id="30194373"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="317" mass="34355" checksum="87B6178A433E2E2F" modified="2017-01-18" version="1">MLPRRLASTVSVPPTHKSPRKIVLVGAGFLGSYVAKALIADPRNRIQIVSRHPEKRNRANFCPVHNQLKSLGNQILAPSPIDITSPSSVSALRETMSGAAAVVSMGGLLTGTEAQMKALQEDGVRRVAEAAKEEGVGRVVGVSAIGAHSKGATAYWRTKGKGEEAIWENHPSATIIRPSILFGPVFTYREIMELVLRFSGLQRPILSIPYALGALQGFFLEKLPENIFTLTRDQVTQLRDDNIVSPVPPMFSQSFEAVLKAFPSSAPSSAPPGDAGLRSVEEILPQYLGPKQEREEGKRTHGRQSASFEEVKSMGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0R7</accession>
    <name>A0A1E3J0R7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030776.1">
        <property type="nucleotide sequence ID" value="XM_019177195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0R7"/>
    <dbReference type="GeneID" id="30194314"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="21385" checksum="31584FFAECE03BAF" modified="2017-01-18" version="1">MASDIAIHPPGSTHPTLTEGGPEGFDRSWFMGKWGIAWSTLPMWKDKKDVTLTYTPLPDDTGAIKFQDLLEYSKLNSEKVNTVKGVDTLTSSGPNAATFDWKGSGWLFFVHSHWEVLGHGSDEASGLEWAVTFFSKTLFSAAGIDVYVRKAASSTTSEVADEAACRALLDRVVHAVQSAGDERVTTLAQGGFPVQGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0T2</accession>
    <name>A0A1E3J0T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030796.1">
        <property type="nucleotide sequence ID" value="XM_019177215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0T2"/>
    <dbReference type="GeneID" id="30194334"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="981" mass="107453" checksum="18484A2D084BF6A5" modified="2017-01-18" version="1">MPSIPHPFTSRDQKSTSDTARPFPSPGSPRLGASSAAQHGQPVKHNPAESYSAGDSSVSASRPGTSEGLRMTSGGGAPSRKASDEPMLSWDEASQVPSRPTSSQGKAIRRGVLKSNTSSFPTEATKGESSNDPMDNDELDVDRKLDHRKRKRNKVIRSCVQCHSHKRKCDRKRPCGRCIALGLTGNCVYEIDEQRDPNDPEVAESDRLRRRVAELEQVVRDLRQKPSARAPAPSKAASILDHGSDGENRRVIIDRYARFKLDEAQAADNVARLGQSSAPVTVKAERSSQEASGGSADYRAEPYTANLLPGDEIMHDTSGRTVYLGASAGQSMLRSLKELASAKGDSGLLAVPEDGVYSGAFPNLRKTFPFTTIWSHENFCGEIIGLLPNQAQSELLWEDWANTYGSYVSPFHIPSLKQEYSSLFAKLPDEKMSVPLSALAVILTICALGCLSRATAAEMFGHPNRAQRTPDDLGGPDVKEPKDLTTSRLQSELYCGLVSERAADAWAIGGNMIKQATALGLHRDPLSLDPRVSAREAEVKRRVWWSVASLDAMFSIFFGRPSSINFYTTNLPQDRADEELSESPGSARELSTSNDLDSRITDQTFHTAYYQLTIPSFEFLDGIFFVDRQASREALYKWFSPPPDAHMASEESPKPKHTYRDALRLAEDLRRWYSHVPDGLRLDVNDSVEDLHKSRSRKRLGQTLALCIKTWTLTLVIHRPYLRAEADPAAYPESTAYCSEAAHMVLKAYRAMAGADISLVWAVWSMSYRAFQAAAVCAFLALRQPGTELAAKCTEDLRGAKEIFAGRLSTWFSSHPVQSDLCQGIIQLDKLVSLANDQHRRSPAPITSYNGMSPAMFGFFDGPPTNAGIGGSQVEQKAPPTPLTEVRAFQRPASSARPLNAAGAFQTNPAQFPSGNDYGLPRSSQYNGGLYNMDQADSLATSLSGDFNGPSPLALPGFWASMFGIKVDKDGDEAWQSEMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J190</accession>
    <name>A0A1E3J190_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030916.1">
        <property type="nucleotide sequence ID" value="XM_019176884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J190"/>
    <dbReference type="GeneID" id="30193989"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="773"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="976" mass="108366" checksum="6DFAA5102E66B3E7" modified="2017-01-18" version="1">MYWPTATTRLVSTPIPLHSPLSHAEPNRKGNFFATLTADSLAVWDVRPTVMQAAVVRSKSSINRFGSNSDVFWTHDGRGLIITANSHHLLFYHLVPSSRPSYDFAGPSTPGPGEGDVVMGWQLTYLGTAFVMGGCQSILCQSHNLLITLRHPPSILSVPWPVPSQLLTPPNSHFPPPPLDAATEAQIECDVWDLSAGKEWLVGEKPAVPTKMTSMKTHGMPVVHTMLSADGRGYVVYLASHLLQACTSDAQRTQLLTGPKYVGSLIHPVPQKIEPLEGDMDKAMEVALNSRFGLVAIGLESGKVNLVSIPSWLNPPRLSHTLDFRRSANLKSSPGQVTSLAWTGDGYCLAVGYEHGWAAWSMGGRLGGWGHRDEEASQSQDPGVLSLFWIPGNLELFVLRPHESSPQLEIIPFAKSATTNQPSPDNTRYAFLQMDDSVMVYRGADQPDMSVINPESDVWQSIKIPAAYISTNWPIRYASISSDGKLIAVAGRRGLTHYSASSGRWKLFQNEREEQQFTVRGGLLWFHHVLIAAVDADKTHQIRLYSRDLGLNEVLHSQTLLAPILVMTLLDNSLLVYTADNMLFHFLILPTNSSIKLHLCGSISFRGILQVPSRVRALSWLIPEAQKTLGDPADDLIVATIIFLVDGKLVLLRPRRARTDEVRYDLQILADRIEAYWTHLHGVGTLENSLWGYDGLNMRVWLDALTIEATTVNDVSDAYESVEESVKVRLDFYPLSILMDKGIIIGVDYETSTRTLPFPIYKISTGTHLFLPKFLRYHLSSSPPSLSQALTLAQHYQHLVYFAHSLEVLLHSVLEDEHPKDHEILPTVVTFLDYFPSALDVIVRCARKTEIERWPGLFELVGKPRDLFELCLTEGKMRTAASYLLVLHNLEELDDVDDTIRLLKQAIEAKEFHLCKELLRFLHSIDESGTALRTAIARVGIIDGSMLDVDGDSPMPTTPSIVLLSATPTDVQVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1R0</accession>
    <name>A0A1E3J1R0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031099.1">
        <property type="nucleotide sequence ID" value="XM_019177067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1R0"/>
    <dbReference type="GeneID" id="30194180"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130152" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="17750" checksum="223B1118A5ACA960" modified="2017-01-18" version="1">MRSFVALALAAAAAVQAIQITAPSNSSGWSTDGPQEIQWQSVGTDPANFTITISLPQSSDRSDITTENIQTSEGSWQYTPDSALETGDGYRVSFVYDGAILAQSEMFSVTDGTSSLSATSSSSSSSTSASGTTTVSETGSTTTGSSASATASDSAADRVTVGGGLLMLAGAFAMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1V7</accession>
    <name>A0A1E3J1V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031091.1">
        <property type="nucleotide sequence ID" value="XM_019177059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194172"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1734"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2019" mass="221322" checksum="DD47BAC5D26D5B0D" modified="2017-01-18" version="1">MSSLARQLQGIASLDADRITSAYGAPSGKSYLFPPDVASGHDIDSIFALAQSGFDELLEIDPEMEQYERDLFSEGAKRTDRLMLSKEENDVLDEALEGCLRRLGRWIGVMAAGKCLEWLVRRFRVHEMNAETVLRVFLPYHESQNFPRILAILTFPTTSPYHVPFAPLIKNAQAIPRSYIVTAISPAKDKSLHLLGDLISSVQQAVKEGVVHRALLTFWSATLVDLLEGAKRAQGVNEAVVRLLVEAFVTLLETPKAGEDAAIYPPLVLLTRAEHLADEPFAAILSSLLTPATGANASQRMLTLLLILNDRSNWTLGLGPQASENLVKVRHLDQILVAAMDKYGFENALKVLLASLLEKPDLHLKTLAAVLEHKVLPDSLAELASNELLQLGSNTIDDIVKATCKSLLSNLRQRHPTIVDSAFLSASSSLAISSQPIDHDLVQKPSDEVAFLDVYAADVSNRIEGVKAVFEMAKKGEDVESIISALEARLSDGEEEVIKTLYEDAEGLLSIMPIERYIAGVKVAFWAAQPSPKLIGLHLDFVSQHLIKAHPESGKIVYESLLFPVFLSTESRQPLTKTEALKLFDGGFKGLEKLGKISSEIVNAREEGVKGAQKSNLVIAKALAEATYASATFAHDVAFLVSQLASPLSAARLLAYMILQTLIVTFRGPRQLSTASAVLVNLAPRLAGHSLRDIKHASEHVGTEYLEGVYKRPEEGRTTLRAVVSILASASKIVKPEEQIIWLASESKDKEPIYKSLAYQIYLWANTAVLPAPIAQSLLRSLLTQLGEDALLFFASVWTSPSALFPSALRTSALRHALAFIRAYAALPATPSNPPVDFQVILPQVLIALQDSERQVRQAAVDVLKGISGGEVMGDVYALDVVYGERSESAQLLKPVDRKKYIETLLEVADEFIIDPLRIRAFHTEVLNMQQHKNRKESAHRRAVLGFLMSHIAAYRSIHPRLALLALLADVHDTSILRSAVPLLEELANDKTEEAAWLSSVPESSRNEFLQVLSGSLRVQSVAVLAENNSEGWAFFLGLLDTAQTDRFRKQLRELSFQAMVHGVFTALTTSQKIDYITALIQCIHSLPTEESHETIKVLEQLELTPDALIELIGHLSDALETSQNRKRQRQDGSEDDRPTQAVLELTTLIDSRTWPSVPASAPLIASLMSILSALLAKRLVIKEGIDYLEQEVLFAILSLVERVDDAQEIHRAHVGIEVIIKVVRASTNPRTSQRALLVASELARLIPEAVLHNVMPIFTFMGASDFQRDDAYTFGVVEKTVSRIVPVMTASLKEKAQTSLELYTESLTFLSIFTDMAGRLPRHRTLPFFVHLVKSLGASDYLAPVSMLLVDRATTKAGRNKEPVSVVLDLPSSVASAFGVTEKVVVLQEVVQELGRLVGDLSRTDKEAFLSETLTETDASDRSLRQITHLLTFLSSLIAQLRGKACDQALIQASVRQLIVLAASMAQPVMASTDIPSSMHSALAGTMLLLSVDNFLAVTAGLLAEGTEQDIVMSLGLFTERLPLMKSEVRLRSTQSIAAIVKKSAAMLATPDLTVGPALDAIKAVVKTAVPQEDGALAGAVLPVVGCANKAKDNWTVVSALSLVELLVRHLASRAIPYVQSILDTTLALIKSPKSAASSVAQAFTTLASTIETIPTFISSKQLNATLITTFFYRSTNEATAYSMLTTLAKKIRTKAIFPVLMEVWKTTQETGGDSEMKGFFEMLRLTLKNASREDLPSMLKPVFAFFLDVFDLRHRLQQKNVDLSMVNDVEESAIGSFLELVTKLNEATFKPLFVRLYDWAVIDLAEGKTVDLDRLNERKIVLFHVMTGLLNKFKNLLSPYMATLLPHIHELLPAFSSGANTSLPLWNLLLGTLAKSFEVDEGAFWTDVSQIELLPLLVSQVPLFLQSTGSPEEPRAISNCLASLAGSTTSETVLRRLNTSTCLVTRSDDPKIRLAALDALSGIWEAQAEEMVGLVPETVSEFLAELLEDESKDVEIAARNVLAKIEKITGSLKEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3B2</accession>
    <name>A0A1E3J3B2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhomboid-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031328.1">
        <property type="nucleotide sequence ID" value="XM_019176853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3B2"/>
    <dbReference type="GeneID" id="30193957"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="227"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="427" mass="47080" checksum="A57612813B18865F" modified="2017-01-18" version="1">MAFRQSLHFKSSFLTPPRSYSQPCFSLRPQRNFTTQGSVVSRQAIGRITPKRIAVPRSSVEGAAPVDNGMPHRSIWRPLIFCAAFGGGGYALLAFYTNYDTQVWSDKMGGGSWWRLGVDQPSDREMARAKQLEGAKKAQKLLNELPATLSFVPNLILVPILRTYVLFSEFYLNSPPAQLAPLALIGGMGTIFLAWKVPRAEKFMRKWFLHRPVIYTASAKREWANCVTLFTSTISHQSLPHFAFNSLALFSFGAASFTFLSAPPVTPSLPTSTHSPHFYAFLLAAGLFSSLGSHLWTNVFRLPRLIKAIQHPARISSPQALANQAAILPSLGASGAIYAALTMTACAFPDSAVGIIFIPFVTIPIGWGVAGMVAVDMIGLIRGWRMFDHVAHLGGALFGFLYYGYGREAWLWTRRKLGAQERKAGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4C0</accession>
    <name>A0A1E3J4C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031359.1">
        <property type="nucleotide sequence ID" value="XM_019176431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4C0"/>
    <dbReference type="GeneID" id="30193525"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="33989" checksum="3EF92673551E21F1" modified="2017-01-18" version="1">MGPRVKRTKKQPISISSSAIRPSPTVSHKLTQAKIATFHNLLKKRATLKRQLDSSPSATASEAVSSSLQEVELEIAELGGLDGYQKASTLGQAKERGGDSSKVLVDWIKTRGYGKGDIRSVTYPSNDLLILTPQSLLEIGALRPDNYSFHKWIHNTPIDLHSQHPNILEQDFFDRPLPASEYEAFDIVSCSLVLNFVDEPLRRGEMLYAMRRQLKQKDSSLLFLVLPLPCLRNSRYLTIPAFVQLMKVVGFDLVQERYKANGKVGYWLWRWAESVGDASPWRKKAVMLDGPKKNNFAVVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4C5</accession>
    <name>A0A1E3J4C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04327</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031374.1">
        <property type="nucleotide sequence ID" value="XM_019176446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4C5"/>
    <dbReference type="GeneID" id="30193540"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="41"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="500"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN95709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70032" checksum="A5701B48FDC6EC53" modified="2017-01-18" version="1">MAAVTKARGAAAKLYSTINRALPIDSASPDGLPPDSVRGEISLEGVKFHYPSRPGVPILKGFTLRLRLETLVGAPGSAKSTVISLIERFYDPIAGTVKLDGIDIKTLNLKRLRQQIGLVSQELTLFGTTVRGKTSNTVSSAPNGNTPPPKKSLSSGERDVVIGGQKQRLAIAKVIVSDPRILLLDEATSGLDTQSEGIGQDALDRASRGRTTIAIAHRLSCRYDRIYVMGAGEVLEEGSHDELLATEGSYAQLVNNQKLAQEAVVDALAPGAKPVQAEIEDVFEDEIPLKRAATSPWMRNRQGARQRLKRMKSCVQATSSMRGCSRSTRLKRGRTYFYAVYRDLFDRSDDNECRLFGCCMIGDGLPFVGYPVRLYFFISAICSALVMFLQASGSSRTGWDLNATLRQKLFHAVLRHDIRWLGEEENSLCWRCDVQPCRPTSKGPGSLWSHTRYDTSSAILNDLDWWSHHRSLLRPSPRSDWYRLCPAARIWRLASIKGCQRMKKLHAASAHLASEAAGAVRTVASLTREDDVGVIYSNALLEPIKVNFKTSIYSQAFYAASQGMTFLIVALVLYIGALWIISGRYSTSMFFTVLNTIVYAAIQAGNVFSLVPDASRANSSAASIFRIIDDRPSIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q1</accession>
    <name>A0A1E3J4Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031482.1">
        <property type="nucleotide sequence ID" value="XM_019176554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q1"/>
    <dbReference type="GeneID" id="30193648"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="882"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="986" mass="108345" checksum="D85C29935EDC8A89" modified="2017-01-18" version="1">MPDQPALGGHQYFAALQPPDRTDTKPPLNTGPGKKRKASSPALTSVADKRRQSIGIDPSTDDDAASSSNSKPAREPKRTRVHFSCVECHRRKQKCDRKEPCSQCVARRVPHLCRPFLNGVEDPNANSDVNARLGNIESLLARLVSSAPPATGATAALVAPVARAYTDNGSPDVSSLTASGEDVFHPHATPPDPAPRVKMPHKPPPSGLFPSNMSYATPPGRTGYGWGLREGRRISLAPDDNFELREVLQTLKESGVSQGHLEWLIAGVPGRRMADGLVDLYFKDIDWTRYKINRFSFMSRYTKFFDSIGRNPTCPKIDADTLKWLPLMFIVLAIAALSAPHELVSRDEQVGWSRRFYGSARSGLEYAKALQRDTLDVLFAGLLASRYMLLTRRPAEGSAPVTTAFQIGLYRDGTVLNITDKKEVEIRRRAWAMLYHIDRTISLLVGRPASISDAHTDTQPPANLDDEEVESGDFDPAGHPLNVPTSYTYVIVRHKLAEIMGRIAYHTFAIQLPEYSTVVSLDRELLTWRDNLPSFFRMENPDTSLDKSHPYLFVQRHLLACEWYYTRITLNRPYLLRRKPQDSRYSYSKTAAIESARADLMSRREFVMEKGKLIVNSGGYRVLNSYMVLGVTIKLDPDSALADELRQLLNVVSGRLPDSQNRLSEPLVKEELAIVEFLTAKPQNKLSRPPPRSAEAGAGGDDQTPVDLLLNLATTRSGKRAAEEEKRQLRLQAAREKEEQSQIAKRNAGAGQISSSPWGYVAPSMPGLDVQQPFGNDSTQRVPRPLQPPPTRRADGSIPDSTDWSPEMALALQNSQRQQIQASAQAPVAQQQLTDGLPGFKTSPSQNQGGNLSLSPYGGFSDLPSFSNETLGGFDAATGFLQSQLPPSNLDQAPSAGSSSSLTTAPGQQTVDGLGDGGIPQFGNATFESFDFNDLGLDVRNNGGGFNPFALPQTEEGNSETSAPDDETMFLTYILNKFANTQPEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J595</accession>
    <name>A0A1E3J595_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031480.1">
        <property type="nucleotide sequence ID" value="XM_019176552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J595"/>
    <dbReference type="GeneID" id="30193646"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="441" mass="49007" checksum="D2818D5DB7898BCB" modified="2017-01-18" version="1">MPAAPHSLPLPVRAVHPPPTALPPQRSVPSDDAYRPPPYIPRVRATGSRSSRASPAGAGLGEDMPIAIDRGVEGIPPGPRPVHRPNAPLAYIMGQAILASTLKGLSLEHIYRWIETVFPWFAHEDNCGWRNSVRHTLSIHKLFEKVERTELHPPGKGGIWQIADGEECHWGEGTSFTKAFPVGHFHHGKCKQVSWEEGKSGRGKGKKKRLSDSSEDGKSAKSESTTPLVPRSPAKIERPVAPRRMSSGTTAVSSSLPVTPHLETTPTLPSITEFTNFSYSPPAYTFPERPLAHGRTHSYEEEHQAKRPRLSSETLPPISLRSRNSQGAIVLPPIPAFAAMEHLPPRYSATNVDSFEAEVAFASRYRRIPAKQTSYERYSSSFESESLPGSSPESRKFQDYGYGNEKAAKWRNRVEVVEVDDRNDEEATRRTPWNGFRFWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5B6</accession>
    <name>A0A1E3J5B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031286.1">
        <property type="nucleotide sequence ID" value="XM_019176811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5B6"/>
    <dbReference type="GeneID" id="30193914"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="360"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="696" mass="75082" checksum="5FF4B776BBADEA39" modified="2017-01-18" version="1">MSIYDTEFSRRIRSSIHDAPPTPISKSPRYDLRSTSHPAASGGSSNLFHDGLGNPDVFGGIGMATSKSASPKMKGKGVQRDYGDSRFIPTRDGTDMHATFQLTDSVRSSAKVKTRRKSGQQQTDGDVRREEVQATFTQLLKTELFPSPSSSRQSPSSLSKARHHKMRQPMTFDTSNIPPNAPSYTISSAGSTPNHHRPPPMALPTSSGAPMERQMSPASTLPPLPMHAPSTPTSGHGRPPGAGPSSSHHRAHQSQVALTSTTHRATSPSHSNPRRSAFSPPPNSVTNGAYSPSTPTKKRILNFGSPGRTLGVNGISASDSLDDMNHPAYSLSPVGKESQRVLLSPRKGIRPISKTPFKVLDAPDLADDFYLNLVSWSQSNVLGVGLNNCVYLWSAQTSKVTKLCDLSPTDTGEGGDVITGLEWTNKGSTLAIGTNNGLVEIWDAEYNKRIRVMSGHSGRVGALAWNSHILSSGSRDRTILHRDTRIADHYIRRLSGHHKQEVCGLRWNTDTDQLASGGNDNKLFVWGGVDARPTWRFGEHRAAVKAIAWSPHQRGLLASGGGTADKKIRFWNSLTGGLISEIDTGSQVCNLMWSKNSNELVSTHGYSGGPVSNQIQIWKYPSMTQIATLTGHNFRVLYLAMSPDGQTIATGAGDETLRFWNAFQKAKGEVGKAAVVGSGIGSGSSIVRMGGFERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5I7</accession>
    <name>A0A1E3J5I7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031570.1">
        <property type="nucleotide sequence ID" value="XM_019176642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5I7"/>
    <dbReference type="GeneID" id="30193737"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="43554" checksum="CFE1CCD6D34B30DF" modified="2017-01-18" version="1">MEDHETPEDLKDPTYNGRSASKIERRTRLEDEIDEACEWLEDEPPIHKVVESFYKRFLQLNVNLRAAIGWKTEILKQKGCRFRFGDFEIGGPQKKASLCELREKFKGLRFPDMVFLAHDMHSDSEFPTIIPDISSPDLSLSSQIPPPDQKLTRQLHVSPDQHYTCFAPLIDKVKAKDEGDEVLNFVYGLHLLIGYVACACDTCASRLGVYHHYGNKIGRLLCLDNCLSQRGLFDESVALKLSTLSSEAPGQDHWEHQQGWAKEDTGARFRRVEKEKGGEEDDERCGDGDDRQGETDKEQRSRRTTGPGEHDGLEDEESDYDSSDDRLDAYIIEERIAKEEAETVEAVIDQYMERFKKEYVLVSLGGFGSVVGEVRGREREDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5N8</accession>
    <name>A0A1E3J5N8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BEM46 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031241.1">
        <property type="nucleotide sequence ID" value="XM_019176766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5N8"/>
    <dbReference type="GeneID" id="30193863"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="126"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="40792" checksum="4A4D1655DC580EC4" modified="2017-01-18" version="1">MVFSSTALTLAKYALGTSAVGVTIALGGLWYFQRKLIYPSNLPEGARTVVPKPIDVGCPYEEVTLTTSDGINIKAYVIPVRRHPSSMSDIRALKKEDRRARAEEEMIKWAAEMGDEKSILYAKSRPTVVMFHANAGNMGHRVLLARNFNVDHRCNVFMLSYRGYGLSEGTPSEHGLKLDIQAAMKYVEAHPILGDTKIILYGQSLGGAACLYAGSKNKDIVTGLILENTFFSLTTLIPLILPQIPKFLLPILLTEHWDASKTLPLIPASTPILFLVGSIDSLVKFPQMHNLRKLREKDGGKCQWKDFERGDHNDTCVQPGYWDTIGRWLKEEIEEGSLVVVEKESSSSGEEFSEVTREEAMEEKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6A3</accession>
    <name>A0A1E3J6A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031634.1">
        <property type="nucleotide sequence ID" value="XM_019176224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6A3"/>
    <dbReference type="GeneID" id="30193315"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="208" mass="23512" checksum="0B1D2AE812F1F17A" modified="2017-01-18" version="1">MATTSSKQMEVNPRGIPRAPFVDNVEEYVGGKEAEVQSTMKKFEDTTAKYRYMEVTIGNRRKALLNKVPDIEQTLQVVKFLQQRRQKALGESPLKTLFELNDTLFAEAEVSENGEVGLWLGANTMLMYPLQEAVELLSSKLSAAQRSLGETAEDLEWLREQITVMEVNFARVHNWDVKRRREKGLIGGQSNMLPSGKNDGGDSDEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6C5</accession>
    <name>A0A1E3J6C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031653.1">
        <property type="nucleotide sequence ID" value="XM_019176243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6C5"/>
    <dbReference type="GeneID" id="30193334"/>
    <dbReference type="OrthoDB" id="2590590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="60419" checksum="153874B3938CFD64" modified="2017-01-18" version="1">MGRAEIESPVPVRTPGDAQRWSSMTFGGPATRRDTVAQLPVTRQPSRSTLRQSRQDGLPTYEQSVQAGPSSSRDGDEQGGLARFGRWRGWVEKRAVERYDGVDRDERRAARRAAREESARQEAETSASPVPLPPSYDATFPYPSPVQYPPASNSSPIENTPFTSVSFGSPFIRHSAASITCSLPVLGGRLLLYGTAEGLMVLDSDEEEAPAKMIWSGLPVWQIEIISSRQSPSPSTPKGSILLFCGGNEDSAKLGHPKKGSGTEIRVYSLASLISLAQWSALQQPGYQGRDMAQKGSRAKEWTMVDQVSIHPLTDRQAPSASAGGQTDLPKAWSGDYTVLQRSTASEKIGNRRRSGSFGNVAVRSQDILCTVVWRDEGRVYVASGMASQAVVHEGTVDQDGMTMFIRKKSLALPAAPVWMGFMKLPENGSMPSRAESIDLADDASYVFEYDRPPSSLSRTSWSYASMRSRQSLSRSGSRAPSVKDNLNLGLYVSFGQKACLIGVSDAVVLGIKSRGHDGDGMGEWGPLKRLVLPDGGLRGEAGEVYAITRGRETFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8E0</accession>
    <name>A0A1E3J8E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031602.1">
        <property type="nucleotide sequence ID" value="XM_019176192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8E0"/>
    <dbReference type="GeneID" id="30193283"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="150"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="49793" checksum="B7AEB5174C4D1DD2" modified="2017-01-18" version="1">MADRSRYQEAPPPHPDLLAFVQDLYDQGITNWRDVNTRLEQDESPWTFGSKSTFRRWRDKHGVSRPGPHYLQPLPYPSDHAIAEKIVALGRGFQSSGSRVIKAALSLEGMVVGEKRLRPIIKELYPDRAAGRIFGKRNIPRRPIGLFNGANEQWSGDGHDKLRDWGFCFYGWRDVYSGQIIIMSLLPSNRDPQNTLWADLSLLLCPGFPRQIATDRGSETDQFSGTHAWLRQNYGQEVSPLIPVHRYLKSTHNITIERCWRGLIKHVIEPVGEVIAQGREEGGFVSTNDAHIRVFWFLFIPLVTDSLNKFIILHNHYKVRYQREKHNPSGCRRIDVWKRPEDFGGEQHLIPLTDEARGILEVWSADAYREGQMQWLTPAEYNICTAGLETLGWTERWSYEDVWALFSRLIAVVIDDLYLELQRQSEEVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8R9</accession>
    <name>A0A1E3J8R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031865.1">
        <property type="nucleotide sequence ID" value="XM_019175952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8R9"/>
    <dbReference type="GeneID" id="30193039"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130262" evidence="1">
        <location>
            <begin position="24"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="40"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="524" mass="54878" checksum="AF92DCC3D83F6A90" modified="2017-01-18" version="1">MPASTPLHALAAVVMSGVALGAADHWILTHAQTIALARMDPIVNPSAISSHVHNIVGASNFDIALNSVSDQLNAACSSTIVNADISNYWAPQLYYHHQNGTFSPIMSGTRVYYFTKGTEVKPFPQGLRMIAGAATTRDVSDTTAFGVRISCDHGEEGFYLPNGTTHPGGCSSISTATFFPSCGLSTGDLDSTDHFSHMAWPQSYNGTILVDDANGQYCPDTHPVKYPTIFAQWNYYLDDNQPWRNDEGTLVFSNGDTLGSSMHADFVNGWTPDVLADAISQCGDGNGPGEDLTTCAPLSKSTNDRSGKRIFIDTNIVFRDVGLQRPIDKLPGCNPLWTADVTTKPTCDEKAADPSMVGPNVLFENLIYRWHVPMAADFVTNTSDLAGLTPSLGNTGDSRLVAWGSEGSDTSRMTVGTLEEIIAGAVGAANGSSSAAESSIASTTASTASDVSSTLASAIATQTSSESTAWISSEGSVSASTSLTTSASVSAASDQVLAIAETSTLTGTSSTATQTQVASTKVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J996</accession>
    <name>A0A1E3J996_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032035.1">
        <property type="nucleotide sequence ID" value="XM_019176122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J996"/>
    <dbReference type="GeneID" id="30193210"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22886" checksum="E0601C5EBC911CD0" modified="2017-01-18" version="1">MDYVFSVYQINLIPTGGQALQIVATIGAAALSDLFKARLSMIVIIAGIGMLGHILLSVWDIGFSGQFAGYMLIYCAVDAGALCLTWFSEICSADAEVRTIIIGLANGVGYTWIAGFPFLMYPASQAPHYKYGYEIGAGFYAITITGCTVLAILLKRYGTPYQNVPKSGDKDADQGSEGEVGGNSQDKEKELDFERTEAVARLSHGNERNQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9A1</accession>
    <name>A0A1E3J9A1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMK/CAMKL protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032029.1">
        <property type="nucleotide sequence ID" value="XM_019176116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9A1"/>
    <dbReference type="GeneID" id="30193204"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="610" mass="67810" checksum="D6B3E7C76F7D7C46" modified="2017-01-18" version="1">MNAHHQTPRSVLDQVGDWKLGATLGRGAYAHVRLATHKNGHKAACKILPALNRNGRRPATTDETVDAIEAHKEVVLLKALSGAGVDGVAGLEGVIEEEGWTFVFLTLYPCSVSSLPTPWTQSSLAIFFRRLLITTHNLHSLNVSHEDIKRSNVLATSEGLPILVDFGFSHFKAFGGLVKSAGGTLDYSSPEKTADVKYDPKANDVWSLGILLIKMAGIPHPYAYTSSDDTSTAVKKRILLGDPKFRWRLRDQGPGGMAELVEGMLERDPLKRWTIPRILNHPYLRTEHPDPPPFKLPSTESTTLRRPSQSVVEDLCFLAYLNGEFALCETSLRIEQRLEGEEACWENRWASMLGAWSKRVEMDWKDIPASITPIKPRHRTAGPVISAPKPAQKTETKPLKEIHLFPNIPLPSFNPPSLHLPDKKLIKPLRSRLHDMKSKEGNKATSNTGQRPIASQKAAGSKLEYASQDEDQMFPHQVSRHKNVLRVKKPKSRMGDSKALYYQANFQVYTSDPESETEEKESPDATPSDTTKNIGTMRLKTKVTQDLVKKGETETGRLRRKEGLGSGVPDNAKSPSSLNEQLQGFLLAPSDDNVTRRRSPRFRTGDVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9C3</accession>
    <name>A0A1E3J9C3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032056.1">
        <property type="nucleotide sequence ID" value="XM_019176143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9C3"/>
    <dbReference type="GeneID" id="30193231"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="87"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="34394" checksum="BB47472019548CD5" modified="2017-01-18" version="1">MLGGLFAAALGAFLVYGAKLDASTSGFALSQAISFSSMILWWVRMVNEMEVQGNSVERIQDYLIIPQEPVHDDRKQPSAAWPTSGEIILDGLSAKYSDDGPTVLDNLKLSIKSGEKVGIVGRTGSGKSTLALALLKMLPTSGKVLIDGIDTGKINLHALRSNVTIIPQDPILLSGSLRFNLDPFGEHDDAELNDALQASGLGATRQRGGSGSITPQRLSLDTHIAAGGGNLSQGQRQLVALARALATASVDFDTDALIQQSIRNLPSSCTVLTVAHRLSTVMDYDKIMVLGAGKLLEYDSPEVLQSRKGSYFAKLVQAMEGAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9X9</accession>
    <name>A0A1E3J9X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032077.1">
        <property type="nucleotide sequence ID" value="XM_019176164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9X9"/>
    <dbReference type="GeneID" id="30193255"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="669" mass="73675" checksum="4779CA1FB513EF55" modified="2017-01-18" version="1">MSNDMGQPTHSGPPAEASTSANGHAAQTVTATSSLLSNVAPVRLPGSLMYEDDKDWVETREAYAGGEDADMEDDATSIKGKGKLSAGEDARPGVGGGKRMPVDREEAVRLMLQGLRDVGYHQSADVLEAESGYKLSTRAGSDFQQAILGGRWAEALALLPELDTAIPSDQTRYLIAQQKYLEYLELGQQKKALGVLRGELARVAKDQNVLHTLSGFMMCLDKEDLYERASWDGAAGISRRQLLEHLEAFISPSLIVPSRRLATLFDQARQFQQSNSPYIDGPTTNSLYTDYEDRQDQFPSVTTHILIDHSDEVWRIEWNPDGSKLASAGKDKVVHIWSVLPVAGLDGTERYAVAPLHHFRNHKDPIDAMAWAPDGKLLATGADKVVHLWDTETGEEIALQTPGLHHTDTISAIQWIPSGSEFLVASMDCRIIFYNRKGMLLRQWSTFPLQFNDFALTPDGSRIVAITTPLKRVANNEGLRSAAIWSQDLRCEMTSIRLTSDGKRALVSCSPDEVQEWNTHNGLRYLRGHSGHIQTNFLIRSCYGGKKDQFVLSGSEDGHVYVWQGSSSQPTEVLAGHTSVVNSVAWNPVASRKIFASCSDDKTVYARVLLQMRKLMRSRRIWQPPVDMDMELQAEDAGPVAEASASGTNGDKDGNGHAPRMDEDVGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBC9</accession>
    <name>A0A1E3JBC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032018.1">
        <property type="nucleotide sequence ID" value="XM_019176105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBC9"/>
    <dbReference type="GeneID" id="30193193"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64100" checksum="6BF46A776E5CA06C" modified="2017-01-18" version="1">MPIRPPSPISLGAALPAHTDHPVSMSIPTWDELFRYQEGDEVVCGSMKSGYPRMFFHRYIQKIASICVDRFGNPDEDLCLMLPSPRVAQEGQAYLLRQSPPIQSRTVPFSVAPEVEIQVLLYPKDNLVEAKAFWQLTGDGISSRFAEMVMGILGEELSSVEVKREEKYLKDQEVTPELALDLEGLKGKSLPLLEGRLAKKALKGRIARGLSPDDARPRALAAGLSSSKPISEEDVYLYPTGMSAVWHCHDMIRRARKGNVAEGKSVCYSFPYKDTLRVLNQFGSGCHFLGAGGTADIPALEAILQSQSKDLSEAPILALVTEVPSNPLLRSPDLARLRELADQYKFVLVIDETIGNFVNVEVMPYADVVVSSLTKIFSGSGDVMGGGLILNPNSPHYTDLRAAQETSFEDLFFSRDATRLEYSSRDYVSRIIEVDNNTFDITTYLQSRSLADGSTPENGKVIKTVYYPRYIAPTTYSQSQRFPTLCKGGFGHLFSLTFTSLAASRAFYDNLDCLKGPSLGTNFTLAAPFTVLAHYSEMDWTEEWGVERGLIRVSVGQEDISHLRSAFEKAVKAAEEAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC75</accession>
    <name>A0A1E3JC75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032350.1">
        <property type="nucleotide sequence ID" value="XM_019175860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC75"/>
    <dbReference type="GeneID" id="30192946"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="570" mass="61679" checksum="7BC3F73774A12C95" modified="2017-01-18" version="1">MSTPPTEQTQLLGTTQPTLAAYASGPASKPVEPASEHHNIAGLSPSRFRLVCASIWTASFLVAFDSTLVSTLLSDIGSAFNASTQTSWLGTSYLLSVCCFTPVYGRLSDLIGRRNAHLTGLTLFTVGTFLCAVAPSMYGLIGARFLAGAGGGGVASVSAILMTDLVDLRHRGMFQGYVNLLYGLGAALGGPVGGWISDNFGWRWAFHIQVPLLVLNGVLIYTFVVQPSNRPQTWKTKLARIDYLGSFTLALAVASLLLSMSIKTSSTKASGEDYAFSDPLIWGLFLASGIFAILFLLVEAYWSPEPILPLKLLTRRTPVAIALSSFTMVTTQFSVLYNIPLFFTIVQLRTSSSSGAHLLPNSILIGAGSLFVGWVMRHTGKYWWLGVNCALCIVATSVGMLFWHKDSPEWLTWVAQAPGGFGYAGVLTTSLVALMTHVQRAGKGETAVATSMTYLFRTVGQVLGVAVSSAIVQSVVQRDLLKTITGPDAAEIIYLIRHSTSSIHTLPPHYQVPAIDAYDHALSFVWVFNLVLSVFTVLALMLVEEEEMPDRQIVRNHVERADGSAFERYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEP7</accession>
    <name>A0A1E3JEP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP64 gene product-related</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032430.1">
        <property type="nucleotide sequence ID" value="XM_019175327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEP7"/>
    <dbReference type="GeneID" id="30192408"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56811" checksum="E07BF7C9AB365E4D" modified="2017-01-18" version="1">MLRPSRGNVKLLLGLSVILNVVVLVALFVPSKQAHELLGEETWAKITQLGNHIEEHRHTLVPEKSCSMCAVDPRLCNELGEENLKRSLGYVGTNLRLRRTLSKLKRGGRLTAGVVGGSVSKGFGIDKDPAYYPDTPTNLNRIVFDRLNTLFPAPNGVKVGDSGRSEDMNSFINGAQGGVGTDYFSLCYGEHLPEDMDLVFIELAINDEVLLRNINSYELLVRSLLDLPRHPAIMNLQVFALEFNTVTNGAEMHTGVAQSYDLPVLSLRNALYHEVLKNASLVNELFWVSPQGKTDLRHIGEKGHNLMGRIGAAYVDSQLCEMEKYEASIPGAKDMSLDQLYPLEPLPRMQVNMKYNADLTLPPIKPQCFSANGHKNPLVPLTNQNWRKWNWKEKNYLVADQPGARVSFKLHTTVGNIEVHYLRSWQYKLGSAKCWVDGDENKAKRLEGYWDQKYNIGRAATIRDDLAPGEHTLTCELLKETADPEGGLEFRLISVMRSVSSAGICEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEV9</accession>
    <name>A0A1E3JEV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STE/STE20/FRAY protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032486.1">
        <property type="nucleotide sequence ID" value="XM_019175383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEV9"/>
    <dbReference type="GeneID" id="30192464"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="792" mass="85080" checksum="83F23589943CF8CF" modified="2017-01-18" version="1">MALRRSSKSQGEGHNMGMTNDEYWTGFTSNSDDYELGPAIGFGASSTVYAAVFTPPSYHSAPVPSAATPAPTQTQPRHLQPTSASLPSTSRKPDLSISLPPTSASLSINVSPGDLTKSNGSAQPKERPCAIKVSGYQYDAEQLFKEIRLLELCRHPNVLRIVTTFTLPPDHLRLALVTPLISGGSIAGILDWRSRLATPTKNRSNFKFGKKRDLDTERPDAGGLEEEEVKGIVKQVLEGLAYFHERGYIHRDLKAGNLLIDGDGTILLADLGVGGDMNLPASPAPGKAKRTGIEEVRFEPETQLGLGPGKRMTSPNDDRGMRKSFVGTPSWMAPEVVTGQKYDSKADIWSLGITILELAYGAVPGGKRKSRDILTNIAKEPAPVLDRMGKFSKQMKDFVQLCLVKEPAHRASALQLLDHLWLRHSRKKEALAQTLLDGVPPLSQRQELLRVPTVSSIVSGTSSWDFASPSVPSSPMRSSQISAAAARSPSVISYKGDYFPATHSRSSSFSAIPPSPRVSLRQWAERSGSVDGEGITGLGIRTGSEGGKPRGRTQNSASVLSGRKSLSFDLQRPSSVTNLRLGAVSPVKRGRELRPARSEDNIEGFQDDGRGLAPMSPLLEVTRPDRAGVGKVEIPNLALAEGSPSLGLVDGVSWMGFDDRVQNSPPDLPSLAAEISSLDSTTLPILPDPETPTKLGRGKEQRISPEPDISLSRTETLVARVSSRPNESLEEHDAKRGWLGRRKSANRNVGGRDTTSGSSEGLPQSMRKTGSWGGMLGKLSGKKGKLSTTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF54</accession>
    <name>A0A1E3JF54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032587.1">
        <property type="nucleotide sequence ID" value="XM_019175484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF54"/>
    <dbReference type="GeneID" id="30192567"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="521"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="881" mass="94757" checksum="FE1ADD3801B997E0" modified="2017-01-18" version="1">MATIFNKFRKSSQSDARSRRSASTNSTSGPLDDDDAPRTSTAPSPSPSRRTGASGSLFIEDFAPPTTPSSNDNTATSSGATESRTPNRPGVLSVPSSAQQQPLGTPKFTLTQDGSNSPRSFDGSPVQNRSPAMNDNGSNEAVGLGFGKSNPRSFDQDDLETPTLDSSFPSTSSNRVSAVSIAADPSSRERANSLAFAEGDVRSRSGSMVSRITHRHGPASPSSLMPADQKGSVSSKKSRKKRDRRRSVTSTASGQSSLAALARGGLQMAGPGTIGDELHIKQHKGRRVTSPLKRSPYLTRGEEGDGDELDDEYGEGLDDDDDDDSDLEDTLSVLGYAVASNRRNADFHQVFPGVDEGDYLIDDYGCAYAKDILVQGRAYISENYICFHANIFGWTTDLVIPFTEIKSIEKKMTALVIPNAIGVNTATARYTFASFISRDTVYDVMMNIWRLCNPNAVMSSLSLPGTNNSRPASISGELADAEGDASSGASPGQQIIGASVKGAGSETHKPTQCACGKDGKHYPETALEATFPSTPEKVYNLMFNSGWLKTFLSDSQQLRDIEYSDWRIGEGSDQLTRSLSYIKPLNGSIGPKQTTCHITDSRDHFEPEDYIAMVTTTRTPDVPSGGVFSVKTRTCFMWARGNSTKVVVTTGVEWTGKSWIKGIIEKSAIDGQKTYHDDLKLSMLSYIQSHISEFLPPGTQASVDTPVPGTPAAEVAAAADKQTEAQEYAEKARKDRQEQDWGMVQAGVDSLVAGGKGVVSGFKFCVDGLSDLVFPSGLSKQSVTTVVIIILVISNVWTYIAFSGGQQRSFLERRSAKRGNDEVAEAVKMVLGQRRDPIQEAQELVRVLDFVEGRLGKLREEAKELGDSAVGGGENNGKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFB9</accession>
    <name>A0A1E3JFB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032636.1">
        <property type="nucleotide sequence ID" value="XM_019175533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFB9"/>
    <dbReference type="GeneID" id="30192616"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="79"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="257"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="474"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="654" mass="72813" checksum="F92A60B8C5D28F4B" modified="2017-01-18" version="1">MDTSHDIAQSSAHPHPPLSPVLTRATTRPRPLPPSNPPEPPLTLLHPSQSYPASPRDEHAGHHDRTKQGKRSWASWLGRGMRRDVMNRLPWYWSDWADAWNYRVIPSTWFTFFANVLPGLAFSLDLIETTGQYGVQEVLLSSFMAAFVASFLGGQPLLISGVTGPITVFNKTIYDIFEKNRSDGPDYLHFVGWVYLWAAILHWIAAVTNAVQGLKYVTQFSCDTFGFYVSAVYVQYGIQVVTRQFGQTSTPSAFLGIMQVASMLIPHYFNAVARSGYVNKHFRRFCSDYGMPITIIAMTGLAYWGRFDQYVLESDMTLPTTASSFQPASDRPWLVRFWQLEGRWVGIAFPFGLVLFILFYFDANVSSLIAQGSEYPLKKPAAFHWDFFLLGITTFIAGLLGIPAPNGLIPQAPLHTASLVVMGYEDGSRTSYQTTLSPGENRQALKLSQMESANKNDTPEDGTGMRRRRRRSSSVQSHTENDAKREVPVAVVEQRVSNLVQGCLCLILMTKPFEHVLGLIPKGVLAGLFWYMGSDALLSSGVSAKLLYLVRDRRATSPSEPLRAVRKSRILLFTAVELIGFGATFAITQTIAAIGFPVIIMLLVPVRVFIVPHLGFTEEELQILDGPVASPFVGSTVIWYLALVADPSTRPWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHK5</accession>
    <name>A0A1E3JHK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S small subunit ribosomal protein L27e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032478.1">
        <property type="nucleotide sequence ID" value="XM_019175375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHK5"/>
    <dbReference type="GeneID" id="30192456"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15702" checksum="D21951D2C2AA1727" modified="2017-01-18" version="1">MVKIYKPGKVAVVLSGRQAGKKVVVIKQQDDGTKDRPYPHAVVAGIERYPLKVSKNMGKKRIARRSKVKPFIKVINYAHLLPTRYQLELESLKGSVSAETFKEPTQREDSKKAIKKALEERYQKGQNRWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI62</accession>
    <name>A0A1E3JI62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032771.1">
        <property type="nucleotide sequence ID" value="XM_019175039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI62"/>
    <dbReference type="GeneID" id="30192112"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="34150" checksum="1BBF6A73108CDEAC" modified="2017-01-18" version="1">MPRGDYNPTSPYGYTPIEWVTIVFLVIFSVSGAVHLAQGVWGKYYIVFPTLIVGLLLEIIGWVARFWSSRNVLYDTPFLMQIITLIIAPVFFSAYCYTILGVGIQALGRQYSLLRANWYVALFVTCDVISLVLQAVGGGWAASSDEHPVPHTPTNIMVGGIIFQLVTMIVFCCLAADFMWRAASKKAYKSKLGQAEKERELEMGVLEEVNSPYSTSIDDAGERRKRVRGWWFVMLGVGICSICIIVRGIYRTVELLQGWDGYLISHEVYQDVLDGIPMSIAIIAINVFHPAFWLSKRRGWIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIM9</accession>
    <name>A0A1E3JIM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032933.1">
        <property type="nucleotide sequence ID" value="XM_019175201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIM9"/>
    <dbReference type="GeneID" id="30192280"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="175"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="612" mass="68282" checksum="67102EDD90F98289" modified="2017-01-18" version="1">MSYDPPQETWSAPTYQPGAWGQAPIQQYNLKPDSGTDPQEILADKLGYMELGGDKEGQGEEESEAAGDSPEPVDVPGLPKISKKNTVDELRDALQKMGLSPKGKKETLRAQTAVQAAALAMAPPPEDPSTPLSDSDNPWEVAFPSDSVLAAHFAEKERRRAERQQMKESGQKFRSFLCFDVEATCRGGKEFDWPNEIIEFPVVLVKWGEEPDEEGKRVLEKVDTFRSYVRPTWQPVLTDFCKALTGITQEIVDASPTFPEVLKELEVWLDKWDLRGEKGLKDAIWVTDGPWDLRDFVPKQLHITPPDPYPNFFHGPYLNIKHGVQSVMSEINRRRVYADAHPDNAANERATMPITTSRRGGKWRPGAGAEGYGAAVARAFRSDGAIPVTAPSTPTRSGAPDAPGSPSTPTGQTPPRPRTDYYLNIAGMCEALGLGEFEGRQHSGLDDATNIARILIKLSEKNVIFEANGLIQPTHSGKRYAWMGESGKVIWEDWMSFQKPQEDPVQKKELDKQRNIEEAKRQKEEADGKKAEKEERKKLVEEEHAANRAAKAAKAAAKDHTEEIWDDEEGYDEDQEYQEQPRDEGPTDSLVFVPRAVSRGQRRGSANRIRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ29</accession>
    <name>A0A1E3JJ29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033005.1">
        <property type="nucleotide sequence ID" value="XM_019175273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ29"/>
    <dbReference type="GeneID" id="30192353"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15222" checksum="34665E6D85066F22" modified="2017-01-18" version="1">MLSRGLVGEIIARFEKRGFKLAALKLATPSKEHLEQHYSDLSSKGFFPRLIEYMMSGPVVCMVWEGLDAVKTGRVMLGATNPLASVPGTIRGDYALQVGMNVCHGSDSVENGQKEIALWFPEGINQYKLSAQAWLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKR2</accession>
    <name>A0A1E3JKR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032899.1">
        <property type="nucleotide sequence ID" value="XM_019175167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKR2"/>
    <dbReference type="GeneID" id="30192246"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO00707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="466" mass="53666" checksum="70ED705DFD15D2F9" modified="2017-01-18" version="1">MAITTEEGSMNVDFKLGDPALMPFFYKHMLPYKPLFLWLNQDQIPSKLFTHRELALTLQNDVYLRYQSFNTSEEFKKSIRDYCPSRFEIGPQYTARPRDRKTLAAGALQPQRRELVFDIDMTDYDEIRTCCSDKKICKKCWGFIAAAVKVLDHTLRETFGFKHLMWVYSGRRGIHCWISDQKALDLNDDQRRNLVNFLEVIKGGSQQSKKVSVRGKDGNDAPHPYLQETITTLSQLFPRLILYEQDCFREEKGWELLLELLPGDRGKSFLAYVLWLVLMRAIAVNSVLRTKWGTDPGRSSHDKWNDLTAILHKNIDTPLGNKIKHAIEDIILQYTYPRIDSEVSKHRNHLLKSPFVVHPGTGRICVPINPSMIDEFDPETVPTVNLLHSEFNQYQARKKEEGAESAGRRMEGGQSTARLGSSANIREDYEHTSLAPYVDMFEKHISAIMRDNRNAKKGMFVTTSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLW0</accession>
    <name>A0A1E3JLW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033096.1">
        <property type="nucleotide sequence ID" value="XM_019174717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLW0"/>
    <dbReference type="GeneID" id="30191784"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="38"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="60382" checksum="356BB07F27587FB0" modified="2017-01-18" version="1">MVGFGSRKLRQQAAETSIVPTATAAARPWHAHSRSYLLAAVGFLGILLFGYDTGLGGGVIALESFATSFKVEGSDDYVADLKGNIVAILQGGAFFGAIIAAWLNDWLGRKRSLMVGCWIFIIGAIFQTAASTQLSWVYGGRFTSGFGVGLMSSVCPAYASEIAPKEIRGRITGLFQITVVVGVAISYWVNYGVTYMDQSRGNIVWRIPIGFQFVPVGVMVILLPILKESPRWLATKHRDADAIANLAWIRKLPVSDPTVQLEYAEIAAAIKEEEGATKGASWREIFPKGNPIRFVIAFVIFTLQQWSGQNSISYYAPIIFQSIGLKGSKSGLLASGVYGIVKIVATTLFIFFGVERFGRKKPLLLGVGLMSLFLWIIGAVFNTHQPAADAEGVPPASIGMAVLIYLYVIPYCFSVGPLPWVICSEIFNNRTRHYGLMTAAATQWLWNFAVTKATPLMVIHLPHGGIFFFFAAVNMISFVLALFLPETGGVSLESMDVIFGTITKEEREAEIVRQTQGLEGRGQGLDDEEKAGSGSGIERQGSIEKAGVEHVESVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLX0</accession>
    <name>A0A1E3JLX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">L198_02608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033131.1">
        <property type="nucleotide sequence ID" value="XM_019174752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLX0"/>
    <dbReference type="GeneID" id="30191821"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO01879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="30295" checksum="178F47A200720209" modified="2017-01-18" version="1">MRPSLRLLTRTPNYPGHIPLSYSQNALLAVGSGVMGVVDVSRGDLIASLSESTAGIFLPALHDKMKVTPEGRQIMKDRPQITSQTIEGLKNLKRGTLGREYVEWMGDGGLEPESRVPVNYIDSPTLAYTMLRYRQTHDLYHTLFSLPPTLPHELSLKVLEFSNMKLPVALLSSVFGPLRLKRKETWSRDWVPWALRTGREGRSLVTVYWEKRWEQGVGELRRELGVSRNDANGVEARWGGYRKLREEERKLRRKGEWVDEPEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG4</accession>
    <name>A0A1E3JMG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation machinery-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033255.1">
        <property type="nucleotide sequence ID" value="XM_019174876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG4"/>
    <dbReference type="GeneID" id="30191947"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="254" mass="27367" checksum="96829A80952F807A" modified="2017-01-18" version="1">MFKKFNPKEDVSSSTSLKSSVQRNIRSQALSQIPFLSLPVYKDPSTAAAAEASAEGEAAPLEEEKKEETSGGGKGKSGKKGGKGKGGKGKGKDKEEKEEKEEEEAGAETVLEEFWPKKDALGLTKCHDRISIYTIQSVPIFFQHFDGPLVPTLKLLHRYPEMLPRVQIDRGAIKFLLAGANMMAPGLLSAGGQLPDGLEKDTIVAIFAEGKQHACGIGKLVASSDEIKKVGKNVAVETICWIGDDLWKVDTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMH5</accession>
    <name>A0A1E3JMH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033323.1">
        <property type="nucleotide sequence ID" value="XM_019174944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMH5"/>
    <dbReference type="GeneID" id="30192015"/>
    <dbReference type="OrthoDB" id="2576621at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108041" checksum="E0BB7439CFCD2C7A" modified="2017-01-18" version="1">MSGQYDTPSPNGVNGGGVMPDNIATWRLQQQPRPAQPPQHVLPQQLNVQTMYQSPYALYQQPSPHQAQGLASNPVLGQYVAGSFPPQSVNNAPSPSEKTPPTICHSQGLGPELPDVTSSPEQLPAPLSQLHRNPRPHPSHALPHNIGASSALPSPREQLPQPIPPPNSAPLGQKRSSHVSLSPRSSTGTKRQRLVVDITESSRESSVSTPPPKRLSTPPVKKDDSTLKAAPKATQATLDGYLSTVGQAQSEIASIPPPTAAPNPPLTAATNPAPNPAPNPAPNPAPNPAPNPALNPAPNPVLNPVPTPVPTPVPNPISNLGPKPAPEPAPKPASHHQPNPPSNRIANPSFSPFLQPSSKSPSNPSSTPPINPPTNLPSNAPPNTAATSNFPVGVKVQPGAKLQPSVKLQSGVKAEPGVKVQSGVKVQPGVKVQPGVKVQPGVKVQPGVKMEPGVKLEPGVKVEPGINAVPGGLIAGTETTAAEKQTVDMSLIRSTITPEALRRDIPGGLFKHLRVRHDKEDDDVVHPPAFTPNPDQLKEILSQLNKHASNLYLKKMAGNGNYVEVWEGWLKTSRKDPVRWEKVLVPLLEVLARTDMEHKVAIEFHINKFAKQLMAAVKDKKLDGTNAIAEAFGRFEAHAFEMFQKESGTTSKDKGKGEASGTKKKADAGKDGIKAKEEPVSKRPATVAASSSKLASNPAASSTVSDMSFFSASLPAPAMKPKPKARPVPPPKAAPASVAKPQSASLLANVMSSFTRQNSIPERSADVKKEAKETRKLKSGRTVGTVRWKDDAELREIREFTPDPVERSSSVSRAISAHDMDMAEGKLLAKNRDRDDIEWSEPIPYVEGDYLPIETEETRAQRERERGALVVPYFEGQTPAEPSEEGVRIIQPFDNQTRQMTAAPIYEAAHAAPAPAAPPPPDQNQIQALLANLNIPIPQPSVRNYYPAAQQHYPGQEAWANASAGPSAYGNEYAGDSGADWKKSSKKRKAQWKPELKQTKTCHHWRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JML4</accession>
    <name>A0A1E3JML4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit RPA34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033346.1">
        <property type="nucleotide sequence ID" value="XM_019174967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JML4"/>
    <dbReference type="GeneID" id="30192038"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37011" checksum="319373D6E0EEAEDF" modified="2017-01-18" version="1">MAKSAAKTTTKSKSKTPVVKKDEDAPMKSASVVDSSSDGESSSESDDSEDDLENVQPKKSKATDTRRSTAPSGSLPKYRPPPGMSPLEITTVTASSPFEWDALASSASSNSGLELWAIRVPKELKPSRLSNLVISAPKEGKPLTGKLDHKGQKYILRTAGSSKNRAEKEEEREEAGLVDSIEMGDGRGAEDKAEEGGEEMEGLRLLVPKAKEDGRLFVAPIPIKRRLLLTPDLTSTLEANSDPSLPSFLQPSENPQSSKRPQPTHLLKFRNHAYGYDTPGPEVTSKKVLGQEMEVEEDVSGQEEVEEKVEKKEKKEKKRKTDKDESPAKAKKKAKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPC5</accession>
    <name>A0A1E3JPC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033239.1">
        <property type="nucleotide sequence ID" value="XM_019174860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPC5"/>
    <dbReference type="GeneID" id="30191931"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000024">
        <property type="entry name" value="Calcium/proton exchanger, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="188"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="527"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="670" mass="73039" checksum="BE3D9ECC0F09385F" modified="2017-01-18" version="1">MVHSSVVDPEPEPDIEGHNPQPTTTQPDSTAAAPNLDTNDVQQQEPDNVSAPTKQPYGLRTILKPRSRPGHQRKPSIIINEPEPIEPRDATGPMRSNSAPTIAGLRPQDAPGPGLTRNRLAPLRNISIPLPPKMGPPQGEQEKVKRKFIEPTWKECFVNTIKYQPLLVAVPIILPISWALHFSHQNPIAIFVTSLLTIVPLAGGLSFATEELAHRVGEAWGGLLNASFGNAVELIIAILALVKGQIDIVQASMIGSILSNVLLVLGMSYFVGGMRFHEQMYAIIGAQMHISLLGISLMAIVLPAAYHYAYPSTSSVVSDARSGTQPEGEELENLLTMSRGLSFILLAVYAMFLVFQLYTHAYLFRVPVEKVQHPLPGPVPHHERVFPRPHWVDSIVDSSSSSSSSSSGSSIRSGRSHRRFKKFRRFSVGKKENRETSGGEGDGHEADSEHDASANATAIGEMQEKATVSPVSPITPVRTPSNHSGSLHPPPNPNIDIERQSMSSNSSIFVDDDGTVHVQPKIKFWYAMGMLLFMTALAGVTAEWLVDSIDGLTETGNVSREFVGLILLPVIGNSVEHFAAVIVSWRDKLNLALSIAVGSSIQVSLCLLPILVLLGWAIDQPMLLFFDPFETITLVISIILVNFAISDGRTNYLEGFVMMMAYISIALVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRG5</accession>
    <name>A0A1E3JRG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033505.1">
        <property type="nucleotide sequence ID" value="XM_019174453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRG5"/>
    <dbReference type="GeneID" id="30191514"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="185" mass="20760" checksum="D4F840EB261C9AA8" modified="2017-01-18" version="1">MITLLTVVALMVTMTVSLLGTALLSGFDLADTSFLLDTSTTHSSNCVSILPCLAMVIFLAFILSYHFNRCDRAPAMRLVSHLSQVMETLCHTWASRALLTPWYQSVLRALQPSYPPRLLLPFYKPYHHLPEDTWRNPPEARRCSQGFMGARKDAEKSGRLRRRDPPPAASVVLWNIAPSQTSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF2</accession>
    <name>A0A1E3JWF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033839.1">
        <property type="nucleotide sequence ID" value="XM_019174032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF2"/>
    <dbReference type="GeneID" id="30191086"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="222"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="664" mass="71897" checksum="F2DB9B048FE437B6" modified="2017-01-18" version="1">MTHTVKATGVPNDPYPFWPRQLKPLHALDGVPDLVARLKQAVLTAAFEGGKQPQVLGKDDEGFSSAASIFNGAVKTPALALVKPVNAMDVSRTIKFCKQHSIEVSVKGGGNGVHGWSVAGHVILDLSELNDISISLPSPYPPTLQESFEKLRVSSATPPEVLDRQAIAQPAKSSIKRHAVDGVEDGTEADGSRGKRKTGNGLGISYRATDALPISNATAGPSTTPRITYVNPSQTPTSSFPFLPTTVGDSSSSTLFNAQSGYTPSYLNLLPQHSLFNTNANPPPFTLVTFGAGVRSKQLDDYTGASPYGAFHVPTSAFPVGSGQFLSGGFGFLSRKHGLGMDNLVEVEMVLADGRIVWLGDEGAKGGDWKEDEDPEEVWWAVRGAGPVIGVVTRFRAKAYYTPSVYAGILIYVFDENTTPSLLRHVRDCIKSATPSLYANIILTAGPPGAPAIVVFQLCFSGKNARHEGENYVQAISSWEGGKSLFSDFSERTFGKQQLAVEDVLKGGYGRKWFIKSDLLLSLTDEVIDQTCARFHSVPDGCTWLFEYTGSNALASPPHTKPGSCFPESHRSAAFTVAALHQWAHDESPEEDARCVLTAEEWIEDVIHPNSPGGPLPCFLQSQEEHRVVGVYGVENYERLKRLKKQLDPDNMFKHAMWPVEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG5</accession>
    <name>A0A1E3JWG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellular nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033850.1">
        <property type="nucleotide sequence ID" value="XM_019174043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWG5"/>
    <dbReference type="GeneID" id="30191097"/>
    <dbReference type="OrthoDB" id="3341596at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000016">
        <property type="entry name" value="Cellular nucleic acid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46978">
        <property type="entry name" value="ZINC KNUCKLE (CCHC-TYPE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46978:SF1">
        <property type="entry name" value="ZINC KNUCKLE (CCHC-TYPE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="171" mass="17924" checksum="41E142AE608800B6" modified="2017-01-18" version="1">MFGATAIPGSRQGCFKCGNLGHIAENCKNASGRLCYNCREPGHESTNCPQPRSNDGKQCYACGGVGHVKTDCPSLRGAFGGGGFRGGRGGFRGGRGGFGGNFGARPRPPVANPDGTPITCHRCKGQNHLAIHCLAPRDEAAILSSKRCYKCQETGHIARDCTKEDVAIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX16</accession>
    <name>A0A1E3JX16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034040.1">
        <property type="nucleotide sequence ID" value="XM_019174233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX16"/>
    <dbReference type="GeneID" id="30191291"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14855" checksum="C90E775DA947D6EA" modified="2017-01-18" version="1">MVQVYMRHGEREATGKKQKGIAAAAEKVAGHWDCATDDENLKYLSTWKWTEPTAYLLPLGSATAFAAGVAFQKVHHTAQSFTSGFLGPNYLSRSTWQITPNSDSSFNSTLSPHNCPALDTVSYSHIQRLFLSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX30</accession>
    <name>A0A1E3JX30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034045.1">
        <property type="nucleotide sequence ID" value="XM_019174238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX30"/>
    <dbReference type="GeneID" id="30191296"/>
    <dbReference type="OrthoDB" id="10404789at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="190" mass="21119" checksum="81B30C2377B0640B" modified="2017-01-18" version="1">MNDDDQHHTYQNYPQYDGGYHHLMYEPDFGMPPYHDVPSSATHHQEGIPGSHNHDFSQYVDPQLMNASFPVGGSALNDFNEFNNLDSWGQIVPAWQLETADDGQGAHMDGPSSVTKSSAMVQGLSTSAGSIHSNIVVSEGKTHQTSPEEEEGCDDDTEDEDWSARENELDSRLKKSQVKREILPLIQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX45</accession>
    <name>A0A1E3JX45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034028.1">
        <property type="nucleotide sequence ID" value="XM_019174221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX45"/>
    <dbReference type="GeneID" id="30191279"/>
    <dbReference type="OrthoDB" id="10290691at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71558" checksum="3FBC7DC08796EE9D" modified="2017-01-18" version="1">MAVLSPQRTAIAPARPHPGQYVSPCPPPLVRTASQPPLSTRKSLGKDSNPADKALSDLNIVDRPSSEGTLTQTHSPLDDIDLSIGVTTLRPVATPFLPGVDQELWGPPTRPMTATDLTAPIPSRSRLLPFKVDNKPQPSKDVELCPPSSSPYVRRMDKCCLANMKPASSLEQELAETKLELDKSRIRASALEKDNQRLIDIMHHIVKSYPSSPTPHSSPPSSQSGFSPLPHPFSHSAITPPTSERSVADEPIAKPNLQAPPAHTQVVSAMGAVGVVPSPDESSQLMKVVLTSKMNFDMMDLEMVMPVVSVIATHHVPTESDDFAGLKKAVDALSEKLVSSNQAYVGAITRSIIEFAPRLCTSHWGNHLCRRLLELGSSMDRLNFLLSIVHDIIPISNNIYGIHVLMRIMTYDDLAEVVGQALFEIGLFDVLRNGSRRLWQIYIVQYKQDNCWPIYKRIIEMLNGRWVDLACTNQDGAIAIQQLLDAPKSQDLVTYCWREMMNRISTVANNPYGCNIISKFLAMPSLFRATCGAILFAYPPVATTHHGITFVNTALARGVGVDFVRYVECLCVEKEGKRPGILAVAESDLGKGHLLYLLSRLTSPDDALRIRHTCQKWSHVLQGSPSGNELLIYLGIVPPNTVFTPRPPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ79</accession>
    <name>A0A1E3JZ79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Saccharopepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01392</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034260.1">
        <property type="nucleotide sequence ID" value="XM_019173555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ79"/>
    <dbReference type="GeneID" id="30190605"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130677" evidence="13">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="124"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="46953" checksum="5A1358263A649F7F" modified="2017-01-18" version="1">MKTAAVLIAALSAAASVEAGVHKMKLQKQPVDADSFTHGAHGLRPSPELEAEWLAFKHLGREYVDQLPLGGMGGAGRKIKGKKQPEMTEEEKEKYWAQMQDGGNAHMLKGGHGVPLSDYMNAQYFAPIEIGTPPQSFRVILDTGSSNLWVPGVGCTSIACFLHTKYDSSQSSTYKANGSEFAIHYGSGSLEGFVSQDTVSIGDLVIKKQDFAEATKEPGLAFAFGKFDGILGLGYNTISVNHIVPPFYSMLDQNLLDEPVFSFRLGDSEEDGGEAIFGGVDESAYTGKLQYVPVRRKGYWEVEVESLGFGDEELELEGTGAAIDTGTSLIVLPTDVAEMLNKEIGAEKSWNGQYTVDCNTVDSLPELSFKFGGKNYKLQGADYVLNAGGTCISSFTGMDIPAPTGPLYIIGDVFLRKYYTVYDLGRNAVGFADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZB9</accession>
    <name>A0A1E3JZB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034354.1">
        <property type="nucleotide sequence ID" value="XM_019173649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZB9"/>
    <dbReference type="GeneID" id="30190699"/>
    <dbReference type="OrthoDB" id="10278432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="35712" checksum="6C45AC1AB2459157" modified="2017-01-18" version="1">MGIHGHQVSLDPLPCDIHSTPPPSDPGSDNDTRSLDGGPIAHEIPRSPEGMEEPWEDRCQILMRENKLLKENCESWEDKCRAIESKQRYLAELSAICDAARLRDMKSELRNILDSIVREKEENMRALRELDRVRDDNLLESRKDIVPFPTSPHVASELPPLSRGISHRISNLFPPRRHSMSPYNLERGRSRVARKVRSVTGTGPPPLGKRVSVEQRLTIENWRQKAGESEEVVMQSPTSLTRPLSPMSGDEWQEVMIAAVHPSDRIDIARTQSSNTDIGPLPAVEGVVLETRKVLPVKARPVTKKYSSWLRRKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF9</accession>
    <name>A0A1E3JZF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cation-transporting ATPase 13A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01441</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034309.1">
        <property type="nucleotide sequence ID" value="XM_019173604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF9"/>
    <dbReference type="GeneID" id="30190654"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="275"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1242" mass="137848" checksum="657C73F5C031AA4C" modified="2017-01-18" version="1">MTSAPKMSATPGILSPEIEALTLHNKTPILARIYGAPFLTLYPLFYYAYHYRYEDWIKSEEWTFIFCVLLGAGHALSFLTTAWSSGINAKVAYTTADSMKTASRIRVIPKKGRGKGDIIPLERKETPGSVEPAYSFNYQRDTYVYSSSDNAFTRIPYPCDAAPPLSIFQTSRGILTHAPLKDKPTPPVTGLPNLDTLKATYGSNECHIPIPKFTELFAEHAVAPFFVFQMFCVALWCLDEYWYYSLFTAFMLVVFECTVVFQRVRTLQEFRTMSITPYQVQTFRDGKWTSVLTTDLVPGDLVSVLRTNPDSGVPCDLLLLRGTAIVNEAMLSGESTPLLKESVELREGTDRLDMNGADRNNVLFSGTKALQVEKAAEGGLTTPDDGCLAVVLRTGFGTTQGQLVRTMIFSTERVSANTFEAFLFIGFLLIFAIAASAYVWIKGLERGMAKGKLLLDCVLIITSVVPPELPMELSLAVNASLVALQKFAIFCTEPFRIPWAGRVDVCCFDKTGTITGEDLVVEGIAGVKSTDPKALVPVTASNKDTTLALAAAHALVLLDDGTIVGDPMEKTTLAALDWKISKGDQISPISKEAPHKAQVHIKRRYQFSSALKRMSTISTVSEPSGGKRWIAAVKGAPETLKGMYVSVPEWYEETYRWYTRRGSRVLALGVKSMNVQVEKVKDIHRDQVECGLTFAGFLVFHCPLKPDAVESLKMLNDSSHRCVMITGDNPLTAVHVARDVEIVDRDVLILDVKEESAGELVWHNVDDSVIIPVRASEPFDQSLFDKYDICVTGVALKQYEQLPSVTDLIQNTYVYARVSPNQKEFIITTLRSLGFTTLMAGDGTNDVGALKAAHIGVALLDGSPEDLKAIAEHHKLERMKKVYEQQVRISARFNQPPPPPPPALREAFPELVKTQQEVAVAHANARKQSPLEKFDMTTITAKLSEMDEDQEVPQIKLGDASCAAPFTSKLSNVSAITNIIRQGRCTLVATIQMYKILALNCLITAYSLSVQYLDGIKFGDYQVTITGMMMSVCFLCISRAKPVEKLSKERPLGNIFNFYVLLSVLLQFAVHIITLVYITGLSKSLEDRGAIDLEKKFEPTLLNTAIYLLGLSQQVSTFVLNFQGRPFREGIRENPPLYYGLLGASLVAYCGATDFIPELNRWLQLVEMTTSFRFRLATSMALDFLLCYVVETGCKALFADIEPVAFVTKGRERREKRRREEALQLREAEKARLIAEGEKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZJ3</accession>
    <name>A0A1E3JZJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidylinositol glycan, class C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034339.1">
        <property type="nucleotide sequence ID" value="XM_019173634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZJ3"/>
    <dbReference type="GeneID" id="30190684"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="38506" checksum="1052F2AAF5C26BF5" modified="2017-01-18" version="1">MAPPALAPPISIPARTQPDPGLPKWEKILWRKQPYADNYVPPDFLAELDDIGKIKVPRPRPSFPALLFAALPITQHISTIAIFLAVLSALLDGRVTPESIGWGCFLGGLVGWGVWQRGWGRWKPREVQDPLIPPPTPIRTLILPPLLLALLSPVLGTLTSATTSDSIWPLAAGLGFVHLLLSDFRTGEDVRVVRRRERNRKRRGSVGWKEIGEEKSLTSSLSLTSALSASVVLASRLPSNAHVFSLILLSVLFFAGWPVVAKSVREAGKGYSLVLTLSTATLALSLIPSAPTPFPQSSPVHPALASLPALIFLLVLFLVTMVGPAMLWYAWRWKVHRGGGWDVAKVRVRSKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZN7</accession>
    <name>A0A1E3JZN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034027.1">
        <property type="nucleotide sequence ID" value="XM_019174220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZN7"/>
    <dbReference type="GeneID" id="30191278"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="970" mass="105174" checksum="ECBE9874D284331A" modified="2017-01-18" version="1">MPHPPGDPRDPRDYSASSKPKGKRPSFSSSVEQNAAHAVRAFSACRNCRNKKVKCMPGPPLPSGSGSPSSLDNPGANLGPCQQCTLAGAECTYPPTRDRAAYSRQYVANLEARVQSLETIQARVMPMLEFFESSARRGSFGPLPNLSGGSVDEHEGEDEGGEPPDSAHLTSDVEDAGQITTDDRGNYRWIGSSNTLSLLDSFSGRPTPGPSHSAPIPVDTPPISSTSRDANPYFGPVAGSGVVKALPDVDQVQYPTREKAMEMIDAFFEDVHPCLPLLLEFEFRRDFGLLMEARRGGDLSWGGGFVSVLFAVFALGERAIVNSRAWARETDKAQEGLDDGHETVLPGEAEAGVIWYERAQILHYTTLKDVNIHQVQCLTLLATFQASVNAMPMSWLLAGQAIRVAQDLGLHRSTARLPMPFHEKQLRSRCWWAIYGLERMMSISLGRPLGVDDQDVDVAYPVEIDDATLETVGSQVTGTPQDLEREKEGATMSGFVALTKLCKVAGRVVHLLYRPLNGRSVSDPSWVMSQQNAINKLDKLLRDWLEHDPSKYKDPSATREVSMLSAILSNSYFAILITLHRNFLPSSPEYPRPKPPLSSQSLSHCVDAARSVIHIASQSRTLVPPSHHLAVHGQYLWSSAVILLLCEVHARDQVVMEAVGSQVEAARRCLQALEPIWPGSRKLKELLNDVSSRAKEVVTHPPLVDPRGKKRKSSSGKERQMPPPLHTLQGKSTPSPVIPQLHMSAWQSSQVPGPAEKRQRLYELSDARTPAREDDVTPLSASSSQAYYPFPAYHLPATPARQSSLPIVNQDMMTPYDMSFDLGGVNFEGLELLQGFSGGAAGFWNTFSYVDGTYPSGGADSGQSSAPMSASASTSGQYMPSGEQLTPGSASGSGVSPSAWQGQGQGQFLQTPGGGSYVNQGEGYVSSDQTGQGQGGHQVQAQAQGQAAFWEQVTGSTFDWQADPNVPFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K080</accession>
    <name>A0A1E3K080_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA-polymerase II-associated protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034569.1">
        <property type="nucleotide sequence ID" value="XM_019173864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K080"/>
    <dbReference type="GeneID" id="30190914"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="6">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="42799" checksum="FEF5CD732A911B17" modified="2017-01-18" version="1">MSIKVDIPKSEQSRADGNISFKKGKWAEAIGHYTNAVIYNPQDPVAYCNRAQAYLKLDKFQDAERDCTSALDLPKGKGNIKALYRRGLARKGLQRNAEAIEDMEAIWKLDRKNEAVKTELEELRVLWRKQDEELKKPPRRPLNPLSLPKPTPSSQPIADLTSQTQKLDIAPKPAPARESLEPTGPKKENSFAAIRKNRDGKKMSFASSSNGSGPGTNGTVQEKEGGDRDKKEEAIQSALHGIFPPSKPNSSPAAQQGAPKGPLVQPAETKTVPALSKNIDTTSTSPGAGLVLLRHFTPSPAFNYSLISLYPPPNIPVILGSLLEPDTLGQVLLALEEGVQSENGEDKERVKMVLEGLKTTKRWGINVAMLSRREKEAGEGAWRGCGGEGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1I2</accession>
    <name>A0A1E3K1I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034152.1">
        <property type="nucleotide sequence ID" value="XM_019173447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1I2"/>
    <dbReference type="GeneID" id="30190494"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="565" mass="61572" checksum="E6D9683BEC2D8297" modified="2017-01-18" version="1">MGFSLPPPHLRAWYSYAFAAEVFSACALAIFLPITLEQMAREVGFYAPDLLEPCQTSSDIVEGIGRVCKAKIMGAWIDTASFSMYVKSVAVAFQAICIISVGPLADSTYWRKRLLITFAYSGSIAATLFLLFPHSSTPLLSALLNIISGAAYSTSIVCANAFLPQLAREDEDVRRLWDERMSADVREEGPIEQDEELSDLSGGPDSGDEATHLLPHQLVPAVMAISTQDLADADNAVKTSLHDTTPESRYDALLSLTTSRLSSIGIAVGFFSGVSVLILLLIPVLALDGSTFSLRLGIGLSGIWWAVFTIPSWLGLPSNGEDRSEISTRQIKEAWVKMGSMIAPSQIRQLPGLYTYLLAWIFLSDGFHTTTYAAILYASSVLSMSPPKIILVGILVQLAAVISSTLVPRLQHRLSTPDKPITNFNILICCVLAAIIIPFYTSLGLVVSFAGLRTEGEMYVLALWFGLIFGPFLSYSRAVYAELIPPGHESTFFSLFSFTDKSASFIGPAAVGLISDLTGNIRYGFLFLLVMLVVPIPVLWRVGIERGRRDAVRWAERVQGRGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Z6</accession>
    <name>A0A1E3K1Z6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034665.1">
        <property type="nucleotide sequence ID" value="XM_019172939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Z6"/>
    <dbReference type="GeneID" id="30189980"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="405" mass="43089" checksum="FD013B4ED4346B05" modified="2017-01-18" version="1">MSVFTKDAFTMSALPSPSPSQPPSTAPSRRGSFANPSLASGQMTPSTDPHIVSINVESVLFDMDGTLINSSGAVVKAWNLFAETYTLDLDDILRSAHGMRTIDVLKKWCKITDPELLASEVIRFETAILNAAEELAKSGTGGTGIEVLPGVKNLLTQLSADNDKRDGEEKWAICTSSTYFYAGKAIPIAGLTTPKVFVTADSVTRGKPFPDPYLLGASGCNASPFESLVVEDAPTGIRSGKASGALVLATCTSHERHELEKENPDFLVDDLSHVKATWDTATNTFNLIIEQPVDRYAPRATPDVTPVITPAMSRANSFSGVGQDRPNFKNNQTISKASDELTGNDSVVGSPAASRPGSPDADGEKRAELEFHRRASQSGSGGVTLDNFRKALAGNAAKRRAQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C1</accession>
    <name>A0A1E3K2C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034767.1">
        <property type="nucleotide sequence ID" value="XM_019173041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2C1"/>
    <dbReference type="GeneID" id="30190082"/>
    <dbReference type="OrthoDB" id="10413226at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130735" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="18685" checksum="1763C86042A4AA0A" modified="2017-01-18" version="1">MLAATFLTVLSAASAVVALPGHSLNSREYDINDIDASCQSTCSSTVTLYQSCNGGTTSDCLKFCVQDTFSDFITCAQCNLDAKNGTESDMESVESAISTIKNSCSFSADPVTGDVAPASTGSATSGSDSTAASASTTAAGSASAAGSSEASGVASSISNSSSSSAGTPSIRLLAGSAGGIAALAGSLMFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2S0</accession>
    <name>A0A1E3K2S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034788.1">
        <property type="nucleotide sequence ID" value="XM_019173062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2S0"/>
    <dbReference type="GeneID" id="30190103"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="739" mass="83185" checksum="D0B7391ED50AA39B" modified="2017-01-18" version="1">MEPLPLHASHAGPAADAVHSPIKLEQVELEDTASSSQQGSPIMVHAVKVEKEETPSKDAKVKKTRQSQSCDACRARKVKCDRPPPGTVTNAPTKDICSHCSQLSLECRFDYVPRKRGPPNLYLKRLQEDQQAAASRKDMPYPSLPPSLPPPQLPQLPIPAIMQQGPATAMPSTATMGNPNGGWQTASPIMGMQPLPLPQVSYLPPMPVPPAPIPTQSYMSSPMSHRGHIPPPVEGPRPMLSSAPPSAHSSPAHLSPNTSFGQHSYEPRNPLDAVVPRPILYHIINLYFDYVYCLIPCLHRPSFTHDLDTNREERPGEEEWVALVLSVVASTLVQLPRSFISMRRKEVKELVLRCHQKVRSYLAQDYQHPTITRSIILYINIYVYSLTDRMSMARADFGTNYAYTIALQSHLESEYTNHNPVESSLRRRMFWLMYGADKTFSAIAALPLYFHEDDCASVALPEDLDDAYISTEGRTTQPEGCVSPLCGFRYVSYLYRLTGEALDKQSHDKLRPPSGVLLQMRLSEVSQLYHRVMSAMDGCPQPLVLNYSTPRSSVASLSPDWGERMKTEIHTMFVNPKGADMELVKDYYLVQQANIYVTQQLVRFIIIQYRDELLEHQEIEQRQVDPNDIARREEIKRSVKEGSQDEREQVVVDLLSILRKIPIKVLAVNSISLVQKVRLVASSLLDSLNPEPEGSSLNGRMADMHTESRAERAQKNLWSFLSYLSEIETLYSWDDDVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K388</accession>
    <name>A0A1E3K388_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034976.1">
        <property type="nucleotide sequence ID" value="XM_019173250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K388"/>
    <dbReference type="GeneID" id="30190291"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="186" mass="20666" checksum="3F051C96623992CE" modified="2017-01-18" version="1">MSFSRTLAHRSLRALTAAPLPVRATPLLLAKRAFTTAQPRRMVVSQTLHEAADRKSKPSVSEWAKNPIVSYEELKPITEQPSDNILVVDVREPDEVALGSIPSAVNLPLSKLKDALDSNFNPGDFQRAFAFPKPSPDQNIIFFCRSGKRSANAAELAGEKGYKSIRNYVGSWLDWSKKESQNKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6E2</accession>
    <name>A0A1E3K6E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">STE/STE11/BCK1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035487.1">
        <property type="nucleotide sequence ID" value="XM_019172545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189577"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1400"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
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        <location>
            <begin position="894"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1699" mass="186016" checksum="1BD0510601E0A1C8" modified="2017-01-18" version="1">MPYGSSGAGPSTPSASLTRRPQGARRRGLPSLVIANPDNSDEDGDSPPKTNTQRSPSGAGASPVSVASSSGRGNVPIPQPPSPSLSVKDRGNLPYPSIPAPQSSPLPTISAFPSPQPLIPTLLPSQSAYGPPDLSPAPPQPPPQPQRHLQRAFTTPIPEPVPRPHAEHSASAGVYPPSSPSRALPPLPSPRAANRQTTLPSPQSHHPPYFQGRVSSPDDLISPATGSEGGGSIMSVNMAHRNRSGSVQGQQVRLQVTTDNEAFHLVDITGMNTAEGIREKVFSKLRIRDDDYPTLSMYRTEIGEAADETPILPAALLSLCSTLGDSRASLKFLVKQTDVPPSTAASVIPPVAPQNDYSYSRRSGMTPITTDLPNPLLDRVTSRHSKEGNADEWGISRSARKPSVSNAGVRLSNSTGGSKSPITEHSNSVGTSSPAIPTPPVVLQGIPLQIREPSILSSSPSSRPSSNNYDATSPIDHSKSTPILVHSGPSNENIYSGNASAGPSNRSRMDQQGLGLSLDDDMDPETRALIEQLQREELDAQREEDERKRKDEELAIREQQSERELWEMMQQMQREKRQREQAQIADDEARARQFEAEQRREEEERQAQEAVRAAWEAEQREHQENRFHTFEQDRRQRKKFFMDQARNGMSIEDTTRDATWTGAGASTDPILGARRPSDGRAPLISTPTPRPSQTPMPARQNSQPVYPIPPSPYPTEGLYPPSRRPSAFTSSPYPEPPYDRLSDPRLQQSTGRTTAPGQRSQTATLPRPESQRSRHPFSYVPHEQSNDHLQTPALQGARSMDNLRIMSGPQGLASSRQNAGYSGPPSRTSITPVSAVYGERRNLQPVAAEPAYRSPTSERAGDSRYPGSVPIRSGSTFPLSNIDTGLVPFPSPHPSSASPKTASWQGSSHPFSSSAPRSSRGSTFDTSSRPNTVHYDRSPPPPTSPETTIPPRRPSTLYDEVYPADGTQTAGMDGQYHQRHATSSFPLDHRSRSGSFSAYRTSSPSPTGGYRRPSQTAHDSDESQLPYAHDPRSESLWLPATKSGKGRSDTDASSLAGTVSSESTVRPSEDNDSSDTAKAGQWDKHLRDMMARNVGDGDQTFMPRKDDEDEATLFISAPPTQSSTPAPTLSRSGAVRPSPSKPNLIVDTASLDEATDQRTSRDRNTGTPSDSATESEGTGDFEGSRIKRGKSFARPKDPNQWSFRPDPEQLYENLDTVFPQIDLDRPLVQGSESQPSTPGAESPSRVEMVGGMLLPVGAAPGRQGGPQAGTGSRQWQGQQGPPSSSSVHLSPGGFNQSKFNKADKRRSLRYIARDKHLDLQRRISRHGPPPAYDFGEAEVPEIPTREYAGVEKTEEQLKKDNRRSSSMWDHKLVEVTRFAQVKGDTILESPADSQPGVVRWVKGELIGKGSYGRVYIALNATTGDMMAVKQVELPATEIDRHDQRQQGMVKALRDEIELLKGLEHTNIVAYLGYETSPEYLSIFLEYVPGGTIASIYRSLNQARFEPQLVRSFTEQILEGLAYLHSKNIWHRDLKGDNILVDGQGICKISDFGISKQTSDAYDSFGQATNMKGSVFWMAPEVMHAYSERSYSGKVDIWSLGCVVLEMWTGKRPWGEMEQIAAMFELFNKRRPPLPADCIISAVALDFLNEKCLQTDPRDRPMARDLLEHEFIRDRDPNWTFEDSKIGKAVAKRGAKRMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6M6</accession>
    <name>A0A1E3K6M6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035699.1">
        <property type="nucleotide sequence ID" value="XM_019172757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6M6"/>
    <dbReference type="GeneID" id="30189790"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8392" checksum="673CF59058EEDB0E" modified="2017-01-18" version="1">MFGFGRLGHIAFDLVIISALLAGVKKSTGYTLKMTLFTDSALRSFMDSYLAMGETIFGMFSGYAVNSRYFKREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6P2</accession>
    <name>A0A1E3K6P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035389.1">
        <property type="nucleotide sequence ID" value="XM_019172447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6P2"/>
    <dbReference type="GeneID" id="30189477"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="394" mass="44682" checksum="E477B47CBD284BAE" modified="2017-01-18" version="1">MCHPRPDQKGPWISRKCAVFIVFGLAIWSFYVVVGRVCTPMIREVSSSGIGRSPGAGTLAAFVVLWLMFIWTYLRIITTPPGFAKDRVNRSPPPDPADYPPPRSTSPVPVADNNNAPDPSTLAPTFNLASQTIHRWTSHNGSADTTRPSAPMVQMPPKGVKDWRQVPRPLPYVEYVPKWCSYCEIVKPSRTHHCRHCGTCVQQYDHHCVWVGQCVGWANHKFFVIFNFWTGCYCLFTMLLLIITASKTSGIDGQTVALVVVSGLFGLFTITMFITHVMLITSGRTTVESYASRDQLERENSLLQKEYGYLWHNLEKRKVRKRWKEEWGGTAVDERWKFGGKMDMWREEMGPGPLGWIFPIGKPLGDGQHYKSNPRFGPHGEWLLKKDWPLGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K775</accession>
    <name>A0A1E3K775_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035244.1">
        <property type="nucleotide sequence ID" value="XM_019172302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K775"/>
    <dbReference type="GeneID" id="30189328"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="55002" checksum="A3E5F094B825307A" modified="2017-01-18" version="1">MTDNSNWLDPAAIQTWWDTPSQAAIHRPYSADTVASLRDVFPPVQCSNAMPRKLRGIFEKLQKNKEVSLSSSANDLVGLGLMADAGFETAYVSSSTHVSNPNESALDISHDTFETVPKNVQSLYRSQLLSARTIRLNAPQSSSPIPLSYEASASTSPSTDAGNDILPLIADAATGHGAHTVIMKHVKLLALSGAAGYHLDDSLSGASRHDKKDGEGEVVVPVCEFLRRLTAGKLQLDIMGSEMISIARTDAPFATHITSTIDPRDRPYILGSTVPLPRDFYHAEGHSDKAEWVREAKLATLDDAFKTSRPEQWAEFEKKSKGLNASEAYALAQKLSSTFYWSADAARTTEGWYPYNGGLSAAISRARITARIADVVWACGHGQGVEEAEAIAKGVQETHPGKWMAYNLPAVATTPSDLKLTVSTLASLGYTYLFLPSSLSGPRILSSSTSPSSPNVRKAFERDGVYGYLAHVAREAEKHKADGTDEEWWWDVMGKFADRAGDAVGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7F1</accession>
    <name>A0A1E3K7F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035638.1">
        <property type="nucleotide sequence ID" value="XM_019172696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7F1"/>
    <dbReference type="GeneID" id="30189729"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="209" mass="23796" checksum="5412DA38F9745293" modified="2017-01-18" version="1">MVRYSRDMMYYERDHIPPCSVAPFLRIYLDSRVTEVERQRRLDLNATFVPGRITKELDHAVRWIEDEEAEETGARYRIGELAWIVEMAKWGYPPGWIASQGESLPAMIPFPAEDDDAEELAIIGGEMEGPRQSREDSAMDIDPPSPLTDPSPPPLSPPPQPLSPPPPPPPTQYPPPKRYAVYNTDMFHYGRLAPFDVIAQVPLGFPKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7S2</accession>
    <name>A0A1E3K7S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_00642</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035758.1">
        <property type="nucleotide sequence ID" value="XM_019172816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7S2"/>
    <dbReference type="GeneID" id="30189855"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODO08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="475" mass="53152" checksum="459C5BA8B116F60F" modified="2017-01-18" version="1">MASDAASREGNTTTIITAATSLDLPAHPIPKTYAELNPKSKPTEFFGPIGTAAITLLCPFFSYFFFFACNDAVGCTPTSLGGFKEAWNLAIDGFPSSAGQWWEWKAAAVYLGWYAFCVICEVALPGERVQGNLLRDGTRKTYRMNGLYTLLLALGIITGLLVQPGGVQAFTWLHDHFVPLLSAALAMATFQATWVYAYSFVSGELLALGGNSGNVIYDYFLGRPLNPTVPGVPSFDLKTFNEVRPGMILWLLLNISCACEQYTRLGQLTASMWIVLIFEGWYTLDCLLQEHTILNQMDITTDGFGFMLAFGDLVWVPFTYGLQARFLAFHPTYLSPLATAAIVAIELYGMYVFRVANNEKATFRAGKNPKNLEFMQTERGTKLITSGWWGRSRHPNYFGDWLIALGWCLPTGLSTPLTYYYLIYFVILLLHRQARDDEACREKYGKDWDRYCEMVKWKIVPGVVSCVFNSEGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRS7</accession>
    <name>A0A1E3HRS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anon-23da protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028093.1">
        <property type="nucleotide sequence ID" value="XM_019179917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRS7"/>
    <dbReference type="GeneID" id="30197150"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000217">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="149"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="55521" checksum="4074B68248EA8B78" modified="2017-01-18" version="1">MSPLPSFFSTIYTYTLGLLLAAFRDGAYSFFGFLNMVRWSSDIVKVVPGKPGLVDFARKNNVLGGERGAKGVTVNEWVEENVPSLKGTFTPAAWLPNGHLQTLFTAAGDFTKVDKVHYVRTHLRLPDGGTLGIDVTPKDHHLKLAPDAPTVVVCHGLTGGSHESYVRNILAWVIKPKSEGGLGGRGVVVNFRGCAGVPVTSDQLYSAGTTMDLALALHHISARHPSSKLLGIGFSLGASILARYLGEYGQDALVKSAVVLGCPWDLGAMSHKLENDWFTARVYSSTLGKNVLRLFFRAYDRNPAIFDDADSPLAGHMGELKKLRKEAGSRTRLRAVDDVLTCKIGGPRGIGAWPFESAAEYYAWASPSNVLSGVKVPLLAINAFDDPVVDGLALPLTGIQASTHIYTAITRAGGHLGWFDGPLFGSPAKTKHRWILQPVSEWLEACARDLRAPGEDARAAVGVGVEVEEVDGWEWVKEARYTIPGVERVGWKVLREGEVVAGEEDEGEGGLVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV25</accession>
    <name>A0A1E3HV25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028198.1">
        <property type="nucleotide sequence ID" value="XM_019179831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV25"/>
    <dbReference type="GeneID" id="30197061"/>
    <dbReference type="OrthoDB" id="3037404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="13981" checksum="97B63E774537E819" modified="2017-01-18" version="1">MGHRPNSTIIQQYYDFGNFEADVVGGILGEGEGGADEIIPLTALARPNNESTYTVKDALRDSPRFRNMQEKWSFLRDCLASGSGEWTKVEPFKSDPGAAIQTSGHIGMLPAIIAAYKSQMRAFVVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I166</accession>
    <name>A0A1E3I166_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028297.1">
        <property type="nucleotide sequence ID" value="XM_019179750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I166"/>
    <dbReference type="GeneID" id="30196973"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="153"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="318"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="903" mass="100349" checksum="7F96533DE95E622F" modified="2017-01-18" version="1">MSRPTTPAYTVRRQGYNSSLSASATASTSRTGTPAPRNPVISLDEWESKAHLSDEQLSSIGAVKNRYADRPLPAKFGGQSTRPSTPAQSLTGPQSPNPALKDSLSSNTASRLSSSIPDPLHPSSITTPQQFLDHFTALTLSTEHEQDSLYRDHLAEISGLRENCELLIELLKGGEEEVQEMEKCLSYVEERSESLRGACEDLLEEQTHLLTHTSQLAHRLTFFTFLETATKMLNNPGNALVLNPDFLPMVKRLDECIGYLSDHRDFRDSEIYLLRYQQCMTRSMTLIKLYFVGTIRSIGQEVGKRLTDQSLSETATQALIYTKFTSLSTSLRPLLSELEQRVSTNPDELAPLLSECNAAYVSTRRNLMGGRVHEEIGRMKPNGSDLVDLTRAGCGYLKTTCMDEFLLYKHFFLSGEAQLYGFLESLCDYLYDHLRPRILHEPSLQVLCGVCTVLQALMVQDIPDEDEDDGLVFHSPAASPGSPYYGNGDDYFSSKPRLYHTGSSRSISHQSSRRRASSLTGNGSPRSRAGSFAGSPGASTVHLPPPPRKKTRRPLRRLHIEVLLRMVLQDAQTRLVFRAQALLSAEVEYYAPKESDLDYPDRLKSGNKLVPRQTTVSLNADDEDDTAVFELPSLEVQNSWYPSLKSTLWVLSCLYTFVDSAVFDDLAQEALIACRKSLASASDLLLAKQGKEKSMDSKLFLVRHLLILKEMTAALDLGKTRRREWSGVGDFLRSLLDNASSLLGYQRGSVAKSAAYAPDARTDIDRSLKSACEDLISILSVRSTFPLQGFIGQCSSYLARAASSTTSTRTDLSAQAFAKPEKVKEVHEEFKKISVKAVEDWKRELRLYLLDKETVAVLMPPALNSIVDTYRQFHDLIRAEYDFAVAAGVMTPSGVKSMLESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5J2</accession>
    <name>A0A1E3I5J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028350.1">
        <property type="nucleotide sequence ID" value="XM_019179662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5J2"/>
    <dbReference type="GeneID" id="30196885"/>
    <dbReference type="OrthoDB" id="2601820at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="53560" checksum="C986801FD191CD72" modified="2017-01-18" version="1">MSKQLFSFLPGGPNEVHIEYPASLYAKDPTKLPQLSPELWAHVLSFCLEPPSFQFDDYQPQRALATCLRVNTTFYIAVAPILYRSPGFFDIGNFLLGADNPVPADLASQTPGVDKDMMYLKHGNTKLPLLRHVRRITPLAWEIDMRDTADIIADQTRSIELANTILQPIIRHQPRPPVENSPFFPHLSQIAIDPSFRGGSLGKQTEIIRTEFSDDFTTLHKSLLLSGPLPKAVCCTDHPSVPVLRALDWVDRKKGTLPRVVTIHTELKEAFDIIFGVTTRIYVDYSEHEDPETFDFLPHEGDALLPRDAVIDFFMEMFEDSSPAFGSTMTEHWEGVVENTVIEVYGLENIVDWEEEEDESDSDEDYSDESDGSDEYSAIREELDRQEGNGPNPRGLNNPSGAPVSESNPRRKYLRKLQEELLEIMGDVGGHMYLPKLRFKLGTDAPPCEACGRGPLAGPLRATSGAKEGSEGEWTDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I988</accession>
    <name>A0A1E3I988_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028435.1">
        <property type="nucleotide sequence ID" value="XM_019179578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I988"/>
    <dbReference type="GeneID" id="30196798"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="786"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1000" mass="103040" checksum="37D03C20727C8726" modified="2017-01-18" version="1">MLAPQLSPSHPSPSFNPFTPTPNPNTTNAHSSMSGSNSTSVFNALGSYADRIKDANGNPIKSSAPAPPAASSSEVAPTSPAVAASSPAAPQQQPKEKSTSSTKDKSSTPSTSTSSTTQTQEKQRQQQQQEDDGLWETVQSSRQRNHSTHTRSDDRDRLPDRSGEGGKEGREGAHAKRGSSSKNWRDRSGREGAGGGGGDKEREKRDEKEEGSSGDRKRDVKERVKKGDKRSNSNSGAPSTAAAVSAEKEKEKGAEKEKSAKATTKSAWNIPSQTIPTPTPSASAPASASNPAPASAAQKTSSSSIASPVTDASKPTPTPNGTSASTSASAGRTDSPKTVVEQEKEKVEEPVVKPKASAPVPKVNVWDLRKKQSTSTVPAPAPAPASTGSGKSTDKSIPNGTASRDDSAPTPSAASASASTAGAGKNGGSKKKSAAAAVGSTAPLVINDAHLWPDVATAVKDKEEKEKKVRSKVESETVNLGEENVAGTATGKKHKWTAIPAHEMLAAADQAAEQSRRQNRLEAKKRSAREGESSSTAAPGKATKPKKASAVESGSVNGAGSKKAVRAAKEAAGSGVKGEAEVGKVNGTGAGEGKGKEQEGKAGTSSPAPPTSISEPNPIPESSAAQADRQLASKPMQTSQTAPIPSHTFTNPTPGAAAAGAGGARPPRGRNDPARGSFGGRGRGGFRSNSAIAHHKGHGVPYTSPPMGFMGLPMEGMPYPSANGNAPNLYQRGFGMGFQPFYPAASASAAGGANGTQAQGIYDPMQYANAYRGASMPPPPMPQTVVPNLDPLRFYVLGQVEYYFSMQNLAMDFFLRQQMDSEGWIDIGMIASFNRIKSLTPDVAIVREVMALSNYLEVREDKVRLAGAESHRWVLPEAKPSTIKPDPSQTAGGSAEAGGKEVVEGAEGVEGSGSGGEGAAAGMGGQRRPANPQRGFVAADVQSALMKSSSAREAAKDKEAEAEASANTSVADMTVTPATSTSTSGDVGKDEKEEESKAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB65</accession>
    <name>A0A1E3IB65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleoporin SEH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028559.1">
        <property type="nucleotide sequence ID" value="XM_019179418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB65"/>
    <dbReference type="GeneID" id="30196629"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN85854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="41553" checksum="92C4A71FF10EF5C5" modified="2017-01-18" version="1">MLQTDLLPPAHADLVSHLVYDFYGERLATCSADQRVKVFHKDEFGKWSQEADWKAHDAPILRLSFSHPIHGSLLASSSHDRTVRIWEESTSLPPSSSSSAPAPGSVRWVERGILTGAKGAVRGVEFGPPDPAFGLRVAFMGTDGYLRVHTSLDPSLNDWSEAHKIHIPSLPAPHSTSSSDDANPFSSSSESAATPSSELALGGWGLSWCKERWWGSLIATFAGSSPVIKIISLEPTPTSILHLTPSSSSSFPSSSSSSSSAPPAPLTALSWAPNCGKNYHLLATGSRDGSIRIWRLEPPGERARVDFTAEGSEAGGDVVREWRGECTAEFGKGGARVGSVDWNATGTMLSTTDDEGVVRIYKRVSFSPLPSSPIFPTPLLFVLVTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICV8</accession>
    <name>A0A1E3ICV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028705.1">
        <property type="nucleotide sequence ID" value="XM_019179349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICV8"/>
    <dbReference type="GeneID" id="30196558"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="91" mass="9852" checksum="E0427288214DC899" modified="2017-01-18" version="1">MSRTAASTPPPQTHFPQKTATPSMRHNAHSTSSPHFARHGHGHHSHSFARRKVKNLPPGAFKKTPEDSAEGDAGDAMGRREEALHGQQSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDL0</accession>
    <name>A0A1E3IDL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028761.1">
        <property type="nucleotide sequence ID" value="XM_019179280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDL0"/>
    <dbReference type="GeneID" id="30196483"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="256" mass="27105" checksum="945675C1E3AE71AC" modified="2017-01-18" version="1">MWEMHSILSSAPAVGVGSTTSDVAGALGATRAKDDVWLVQVVLMGTVGGGTAGGVAEGGECFGGGERPSGGRGASSCDRRLNDPVYIRYEPPTQSDDSALGPDFYRSRGRLVYQLSIALADVFWAPTTQCWAYKFLYVNVPTRAAYRKSENNLLPKERALVSDFRPPLGRSPPPKHSPPSATPPAVPPPTVPIRTTWTNHTSSLALVAPKTPATSEVVDPTPTAGALDKMLPAVPLPTVPTRTTWTPHPSFFAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEM5</accession>
    <name>A0A1E3IEM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028856.1">
        <property type="nucleotide sequence ID" value="XM_019179098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEM5"/>
    <dbReference type="GeneID" id="30196295"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="963" mass="106660" checksum="89145393281AF34D" modified="2017-01-18" version="1">METETRRLLHAVAFPSPNEQYMKDQETFAALYKEPEFLVTLQLLSTDRGLSHNERLMASLVTSRELKTKWRNKTVVPESRKPGIRQSLFSFLHEAELGIARPQLSLLVAIARIEYPKTWVNLPQILLDALTSSANCLNDPLNIPADAAVVLLNVIWTINALVKDWRTVRVAQGAAAMQTFEQAFSGPMQSVMEVWARSAREGGGNATVEEAGRYAFKILARFCQWNWAKAKGIQSPEAIQRITLLLQHTVQYAPVLQSNRVQTISSGASQDKALRSAIKHLRSIGKWWRVMIATDPKRFCAIEGVTSGVGWWWSAVGGVVANSDGAVANDVFTPDFILSAFHLLVDKLLPLTSTDLEDLEDEPEEWLVRESNDEEAWAFEFRPCAERVLISLNNACRNVPKENRVIEPAMLKMVAETEGMSPNDLPNVLRLEAVYCTLGRLSRSMASYGGIDINNLLTQMGSWMGQDYPLHRIVKRRVAWLIGEWVTADEDSAKLPVIWQMLMYLLSERGSSSDKAVNLTSAIAVKECVDLWELPIDYFLPYLEQSVHELVKLLGEASTLDGKKYVNEAIGVVIERVGDKMLPYLPSVAQSIPVLWSSAGGLEGEWLFKASLVVLSTKLVTAAKERSGELMELVIPLIEESLQPPAKEFFEEDGLILWQTAIYNATSLHQPNVSTSLIHLLPGLLQVLGENMDLLSTLVGLVDSYLLLDAQNITQEYGQVLASSLNKALVTSGSNVGSVVRILETLVLWVSLVPVPSLHPLLLQSGIFSQITRSLEDDKASGQILASYLNVLANLAISDAGSFLQMVADAAAMEHKDPHQLLDEVLDAIWRNFDYVGGTKMRKAVAMGVGSLLLSGNQQVMERFDGEIMNIFLDVLGETQNNEAEGENGLLCWGDEHAIVWSDMQATPEGARRTAIESKDPAYAVPLKSFIIGTMTQGMTIGLLPYWEKADEGTKNSLEKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEX2</accession>
    <name>A0A1E3IEX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028678.1">
        <property type="nucleotide sequence ID" value="XM_019179322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEX2"/>
    <dbReference type="GeneID" id="30196530"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25987" checksum="822B371A26408161" modified="2017-01-18" version="1">MRLAESPSLSLFGSLPLAKLDARLPVPSLYNHKQFMMSAQEEHQEQDWQINDEDIGMDSDSDGDNDKYDGEIIIGGPGPSEEDEMMMEVEGEGEQQREDISVGVNSCPHHIAPSRHRHRTSQQRRIATLLLLFFSSPHPSSSRSPSSHQPSKRQLPSNSPLRPSTSSNRSRLTNANSISPCPSHSSSPSLLRQQPPRQPTRRQAAGAAAVAGAGADTVGVGEAAAVAARAGTKEHEVWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFN2</accession>
    <name>A0A1E3IFN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028984.1">
        <property type="nucleotide sequence ID" value="XM_019179066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFN2"/>
    <dbReference type="GeneID" id="30196260"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="70" mass="7749" checksum="2D98090594730904" modified="2017-01-18" version="1">MPVIFPNRSGAHRGFRHSFFSSDHASNTVYSSFIISKMIGNAQTILDQMSMPETTVLLSLEDTKLDSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGR8</accession>
    <name>A0A1E3IGR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029071.1">
        <property type="nucleotide sequence ID" value="XM_019178977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGR8"/>
    <dbReference type="GeneID" id="30196169"/>
    <dbReference type="OrthoDB" id="2571152at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="44191" checksum="E8E8A345E9D26BA4" modified="2017-01-18" version="1">MSYHIDLTDLTPLAEVHDQILHLLYLSSPTLPLRLSKSLYRHFIPKIYSHLTIDSSNVHPILSGLGSPKGFKAQALSFVEGLKIGVDDVGWNGLRLALHDTLLIPNLPCPLFPRLEHIHLGHSLFKPYGGIERMFEALLPSYIPPPCHVSFDLALHHLDIDHSQQDYVRDYNLATMRRLTNFMLVFFHEQSAYHVTFRLFDPASIATTSTKISSQEAKPYREAFWVLHHSPIPHLDRFMLGEWLVPRLLRPSGSSEAVRGELEAYFAGGMEDRFGMVYGRDVGGYVRRYDVWFLEEEEEGDEGESDDGYSTPVWNKPTTCGFSLSAIRIVSSIPSIVPHRRRLHEDKAAFLRAISIQATARFESAKVVSLSVCGVIVSSSVVLFIYGLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHL3</accession>
    <name>A0A1E3IHL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029150.1">
        <property type="nucleotide sequence ID" value="XM_019178873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHL3"/>
    <dbReference type="GeneID" id="30196052"/>
    <dbReference type="OrthoDB" id="2138648at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8484" checksum="28B956B88E5AC19E" modified="2017-01-18" version="1">MSDLTDKQGNEIEVGDTVFMNYRAGKMEGKVDEILSTEDDVANSDLNVKNPPKVVFTNQNNKQSGHNPGTLTDLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIE9</accession>
    <name>A0A1E3IIE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029049.1">
        <property type="nucleotide sequence ID" value="XM_019178955.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196143"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1170"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="741"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN87706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1339" mass="149220" checksum="6880C75B90F4C6A1" modified="2017-01-18" version="1">MSTILAPWLLRTYRKKASQLATVRSDLPNAETSEEDAMSWRPGLVKPAGKSDPGLRKGERYLLKDFSGLVKAGEMMLVVGRPGSGCSTFLKALAGHRDVFAGVDGSVKYGDIEAGPDFKPYAREVIFSSEEDLHDPNLHVGKTLDFALRMTTPSRRSRIPNKDGGESMSRAAFQEKRKWELLRMFGLLHTHDTRVGDQYVRGVSGGERRRVSIAEVVTTKASIQLWDNATRGLDADTALRFARNLRTLTDIDRNTTVISLYQAGNGIYDLFDKVTVIAEGRVIYYGPGGEARAYFENLGFVHPDGGNTADFLTAVTARNERQVRPDFQGRVLTTPAEFATAYNQSDIAHRMRQELEAHLVDPKVADDTQNAKAMIQLEKSSWASKTRPEEVNFLDQVRAAITRNRQQRWGDKWTFWMRPATLLLQSLLAGSMFYKIPMSTGGLFLRGGTLFLSLFFPSSISFSETTAVFSGRAVLSKHKGFSMYRPSALLIAQTLNDLPVYFVMLLMFTLIIYFMTGLKVGAGYYFTYLLFVYCTTLCTTALFRFIGYSFSTFNGASKLSGFVFLLLSTYAGYLIYIPQMHPWFSWLRWIDPFHYSLEALMANEIDGLNLQCTAPNLAPYGGDYASHSQGCAITGAKPNDIVLSGTAWLDSALRFYKSHVWQNFGILVGFWVFFLVLCAYAIEKVPAAGSTKSVLFYKPGGGGKYIRQAQRKGEASKHEEDGPGEDIKLNDLNGVGSDSVLTWKNLSYTVNVNGEPRKLLDNVFGYCKAGTLTALMGSSGAGKTTLMDVLAARKTEGEIQGEVLMNGKQLPVSFQRATGYCEQMDVHLPQATVREALEFSALLRQPRHLSNKEKLAYVDTIVDLLELQDIEDALIGTPGAGLGIEQRKRLTIGVELVSKPTLLFLDEPTSGLDGQSSYLIVSFLRKLAAAGQAVLCTIHQPSASLFARFDQLLLLRGGGQTVYFGAVDQLSDYFEKHGISIPGNVNPAERMIEVVSGDISKGHDWHRTWLDSEECRARAEELDDLIDTGSKLASAVEGDEFEYASTKGAQLRLVTKRASVQLWRNTEYVMNKVTLHISAALINGFSFWKLGDDYADIKNRIFTIFLFVFVAPGVIAQTQPKFLRNRDIFEAREKKAKIYSWQAFCFAEIAAEIPYLLVCALLYFSCWYPVVGFSFSPAIAGPVYLQMTFYEFLYTGIGQSIAAYAPHETFAALVNPLAIGVMVMFCGVLVPYDQITAFWRYWMYYLDPFQYLMGGLVSLTLWDLKVHCSPDEYAVFDPPSGMTCTQYMADFLSHAPGYLSNPESTSKCEYCLISKGSDFLEGLHLSRKLDAWRDIGITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIG9</accession>
    <name>A0A1E3IIG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029198.1">
        <property type="nucleotide sequence ID" value="XM_019178715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIG9"/>
    <dbReference type="GeneID" id="30195872"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="401" mass="43736" checksum="0E556ACDD774F857" modified="2017-01-18" version="1">MINNSRRSKSQITRATPSNSSTNPFPHIHPPPQGRVPIYDPQDIYGAYPQPAYHPYQVPYPPQYQGQQGAIHPPRHDRNRPQGPPVPLEPPREETPTYPVISTSMFSTSLNAAQPPPPPAGPVSNNNPGETYLSGFQVDYPRVEAGRAVRRPRVVVEEDEKDEGSGVRKVLVGRRKVVVKPGVGLDGLDGDDVGEVFPPPAEAYIILRPHRVPRELWDDGVFGDFSDAEDCPSRGKALGLQAQPRGFPALNAPLIVQLTVYDSQGHVVPVDSPVLSRRLVHTIMVVDLVSPDGKEQRSSIKLKPNNDLLNSSSPESSPAPPIYRRNLLGATVRASSVLSRGGGRHPERGIFFVFSELVVRNFGVFALRMRVADLAGPAHLGTSIGVTRTLVEGLTPPFEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIK1</accession>
    <name>A0A1E3IIK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029232.1">
        <property type="nucleotide sequence ID" value="XM_019178749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIK1"/>
    <dbReference type="GeneID" id="30195906"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="14436" checksum="32FFC02AD901BBDF" modified="2017-01-18" version="1">MPRSSRSSARPSPPPSQQSRGAHTAAYPAQHAPPPAAQHAGVQQQRQPGMLAQAASTMGGAMAGSVVGHGISNMLFGGGGGQQAAPVEQAQAPVNQQQAGMSCDIQAKDFTKCLEATNGDMQSCGYYLEALKACQAAARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIN2</accession>
    <name>A0A1E3IIN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029197.1">
        <property type="nucleotide sequence ID" value="XM_019178714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIN2"/>
    <dbReference type="GeneID" id="30195871"/>
    <dbReference type="OrthoDB" id="2569417at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44447" checksum="54B2AA5BE3A1EA05" modified="2017-01-18" version="1">MSGDDAELIKSLNHLDVKDVQDTDASRTHEDVDRRVLSSSFTPGSEAADSAGADRLTEVTQDVVSSPSERSPDPLPSSIHPDFSIQTNDDFLLVTDDDVGFYVNRAFLLEHSDFFRDFEEMESDIRQDDDAGKGRTQAVRRDMPGALSNGLRVMLLKVKETKSSLDLYDYKRKVFRSQELWEYEYDLEDLALAFRIANQYGFTRFSAQARLSIPKTSIWFQYLYAAFEADETVAKAFARSTLLSDLTELCPRPLLPVLDKHHAPYAALLRNIHRRNPFSFYKKTYSLLSCSTANYDFLKKSQADFKDKRLVECGGEECSCKKSGFWWATASKSGGKALRSNLASWPGRDDDTLWSEIDMSIRRSVDCLDCRDSLLQFFKPLWDDLAALWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIS1</accession>
    <name>A0A1E3IIS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S small subunit ribosomal protein L28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029237.1">
        <property type="nucleotide sequence ID" value="XM_019178754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIS1"/>
    <dbReference type="GeneID" id="30195911"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000004">
        <property type="entry name" value="Large subunit ribosomal protein L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="17131" checksum="104814F257C1E459" modified="2017-01-18" version="1">MSADLTWLLLRNYNSFQVKGGHGPTFSKEKGNLLNKSSQKYSGLANSKVVAVAASPNGGVTITKIKADAKPNQVASARSHVALKRSTGPRRANKIVAGETAGKGYRADLRAVAVARTSALLLAQRRTANPPKTIQRGRKQAPSAVGKAAAEEEVEEIVVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIV3</accession>
    <name>A0A1E3IIV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029267.1">
        <property type="nucleotide sequence ID" value="XM_019178784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIV3"/>
    <dbReference type="GeneID" id="30195942"/>
    <dbReference type="OrthoDB" id="10283147at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="35311" checksum="EC45E742713DCEAE" modified="2017-01-18" version="1">MVSVCEHERPEASGLTSTACDITHLPFPPEVTILIYDYYTDVPLPGSREYTDLLCLDRTTFAKKISGLYEDIILSSRNVEAFFRSWREWYAKALGPPDPWDFRRPAPSDMCHIRSFLANTPIRQLTFADTTALTTTLQFYHDWQTSIWCKARLSSPHVSPGKIFLQLSRVSFLAPSLGQSSSDHGLWPNFGSLSTGLWRWVSTNSVSLQVPKQPLDHGVVRAMSEYLKWQEKAGFELLVLDCAVPQDLPWAPIVERMSVKYIMKGRELEDRLGDKDSVALYNLSPRDATQWLMDLAERSLSYIPSISSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ41</accession>
    <name>A0A1E3IJ41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing factor 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029274.1">
        <property type="nucleotide sequence ID" value="XM_019178791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ41"/>
    <dbReference type="GeneID" id="30195949"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000107">
        <property type="entry name" value="Chromosome 19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000036">
        <property type="entry name" value="Pre-mRNA-processing factor 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="715" mass="84133" checksum="62E04DD79A4A8B9E" modified="2017-01-18" version="1">MSDNRSLWSEYKNAEGRVYWSHATTKQSVWEKPDELKTPFEKALAKTQWKQYTSKNRPYYVNSATKETKWDLPAELVTLKAQVEAEEARKNEREARREKGESLSPSPSPRRMSRSPTPEDIRELRASAASAIAIYKQDTSQTASPAAKVDTPIATKPQEDLLPIVMPTGGFQNKHEAEIAFTYLLKREGVNETWTWDQVMRKIVLDPLYNALETLAEKKGVFEKFTNGILEERRAAKEARISRFRPIFTKLFTKSNAIKSYSTLKTADRVFAKDKYWKEALPEEKRLILEEYTDKLRREEEVAERELKEYNVRTLKSLIPTLSITVSTRWRAAHDLIISSPAFRADPSLQQASVLDMIKAYEDYAYKLEQEHKEESRKLRIEDVRRARKAREGYKALLKEMEERGDLKRTSKWRETYGIVKGDPRYEALLGLPGSSPLELWMDAIDDLSEEVSRAAEKIEYALGKAGKEFKKGTTWEELEGWCHETHMDQQISERLRKEVFSLLQSRARQQEEEELRKAERRQRHRIDDLRYALRKVDAINIDMSYEQALPHIKDVAEFKAMESEEEKQLGWEKFVRRQKEKLAEGESSTHHRSDRDHRDRRDRDRDYRSDRDRAYYKTDRMDVDPRERDDGSRGAKRDDRDRDRDRRDRGGRDRERDDRDRRDREYGREKARDKRVGLEDDDRDPKRRRLSSVSSVAAPAAKKDRPEEVEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJS3</accession>
    <name>A0A1E3IJS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029400.1">
        <property type="nucleotide sequence ID" value="XM_019178699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJS3"/>
    <dbReference type="GeneID" id="30195856"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="331"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="432" mass="48430" checksum="385DEDBC27710085" modified="2017-01-18" version="1">MPELPEVERARKLIQETCVGYTIAEVDSVEDKIVYTAGTDHEEFANEIKGRTITGCERKGKTFWMTLSGDGRYPVMHFGMTGMIQLKGQEPTWYRRRPKESADVWPPKFYKFVLKLQPQEGSVASEALELAFIDARRLGRLRLVPSPVTDHPPVSLLGFDPILSHPSFEDFQELLKKKKGTIKGVIMDQAFSAGVGNWVADEVLFQSRIHPSTPVPLLTPDQILALHDQLHEVCQTAVDVNADSKSFPEGWLFRWRWGKGAAKKKKGKKAKEQDEEGEEDVEPAGKSFLALPDGTPATINFIEVGGRTTALVEEVQKMPEGVEIRPKIIKGSKKKVKEVEEEEDADSEDDDEEKPEKRARSTTKIQRTVAAKKRKAPDVDVTEEEEEEEKPAQKEDFEEGCQAPESNDQGTINETLKSLGAQTTFAKVSRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL57</accession>
    <name>A0A1E3IL57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029250.1">
        <property type="nucleotide sequence ID" value="XM_019178767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL57"/>
    <dbReference type="GeneID" id="30195925"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8743" checksum="0765F87AB86A4C1B" modified="2017-01-18" version="1">MADVLTQVTGVPVGTPQITKEIFYSDAHKQALGEEYWAATHTSKAWRDIEASKQVVPNPMTMEVWARQSSELRKLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM49</accession>
    <name>A0A1E3IM49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029571.1">
        <property type="nucleotide sequence ID" value="XM_019178415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM49"/>
    <dbReference type="GeneID" id="30195562"/>
    <dbReference type="OrthoDB" id="2565062at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="313" mass="34193" checksum="FDDF6A62D4101C44" modified="2017-01-18" version="1">MTAGHKSKQSKRLSFQKTLLLFATLRSDSVDMGYTILLQWSFSIPAGRPTTLADIVSARVLEIYGHSTPTRSAIQLRTYRAQFPSSDIDPTQVSRYLTVMSPIQPPVPSSQAKPRDVNHVDDTAFLFMDDKSAGGTTALEAPGDTAVNESSKSKQRFQCIAVRPVSHVPPMLQSLLSPFVLGLTKAARTTASQTSSTPVPTPLPGSTFAVTSFTFPPLPSSSPSVTLRLHILPQTAGSIFLEGEHIGPSDGKTMEEIKKEIRDFLNQCVLEDTGEKKWKDCHEGTETRGLEGVERAKRTMSSLAQMLRRGSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IN54</accession>
    <name>A0A1E3IN54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029416.1">
        <property type="nucleotide sequence ID" value="XM_019178509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IN54"/>
    <dbReference type="GeneID" id="30195662"/>
    <dbReference type="OrthoDB" id="10577211at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15834" checksum="EB4EDCB90C57D6B8" modified="2017-01-18" version="1">MAPPSTTPIATQSRARPAPSLARTSSPLPRRTSNRSATAPSEASRTTLHLPRPRQPTFRSWTLPWSDLYIQVLAVLWGDERRDEYERKLAELLETRPCPRTLLEEVDFGDPAGDEDEVSVDDRADESGESFWEGGVLDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INE1</accession>
    <name>A0A1E3INE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029496.1">
        <property type="nucleotide sequence ID" value="XM_019178589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INE1"/>
    <dbReference type="GeneID" id="30195746"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39498" checksum="608B0CFBB9C44300" modified="2017-01-18" version="1">MRSALRVLPKRRLSPRLPQPRFYATLNPNTPPPTAAYQVFDEPSKDLQRSRAIIRLRELQAAKAKAEPAQGDSQISDEDGLRVVDYLREEVSERLAERIGDLRVPPSSIMELSAHAGQLTQILQDVLADEVPGQGQNEGQGRQEALYRDQDSCFISPPERIQASPSDLLAHPEIEPLKEQVEAVVSSGGLQWVGDIVGGLTQVRHLLKPDGVFVGAVFGGDTLFEMRTSLQLAEQEIRGGIANRVSPMINPTDAPSLMNRAGFTSVTVDVEDLTINYPSMWELMADLRDMGESNAILGRRATIGRDVLVAASSIYQELFGNEDGTVPATFSIIFLIGWKPGPNQPKPSKRGSGQSALQDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQG6</accession>
    <name>A0A1E3IQG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029698.1">
        <property type="nucleotide sequence ID" value="XM_019178260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQG6"/>
    <dbReference type="GeneID" id="30195406"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="259" mass="28290" checksum="4E2833CC593C3ACB" modified="2017-01-18" version="1">MSAATTNSTAPTTTAPTNGATTGTGSTSITQGVKDFFKGSHKADSTEVCTEHAPEIVQEHVRPQEHTQTAEAIDRERHVHHHQHRIQPIEHKVALDPKHVHVTGAPVVREHKEDMLPEHQETLHAQRTLHTNQQTTGDIEKSHAHIGTHVNTHEHHHIHETIQPVIQRETVQPTVVHHTAAIHEKVHEAPIVHEVTTLPSIGHDQFLKLKEGLSGATHSDKSHSHQHYEGAPRVGGHTSQTGTTSSAAPSTTQGATTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS93</accession>
    <name>A0A1E3IS93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029951.1">
        <property type="nucleotide sequence ID" value="XM_019177912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS93"/>
    <dbReference type="GeneID" id="30195048"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20770" checksum="C1DB626EC2B655DD" modified="2017-01-18" version="1">MSTPTPATILGSTGLTGSENLHALLTSSNPFSITATHHPLPHPFPLPQMRTPKRPNSPRRTNLAFALRYSRRYCPKKARTRGRSEKVDWELNRDLATRAKADGARTAILVSGSHASRDSSFFYLRIKGQLEEHFTTLGFDHVVILKPGMLLGPRERVDWAEIGLQKLFGWARWAGVGTDALAVDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISQ2</accession>
    <name>A0A1E3ISQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyamine transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029833.1">
        <property type="nucleotide sequence ID" value="XM_019178114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISQ2"/>
    <dbReference type="GeneID" id="30195259"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="195"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="639" mass="68989" checksum="AC92E69BFC61BFDC" modified="2017-01-18" version="1">MSRDPLALGQEIVPSSPAAPHDYLASQNTGGSHHDESPTPTLAGPNSAHGTHGYDPEKNDDRVAGLGAAEVGTDYEKTKEIDEKGEDPAPLARDHQTTSGTTHAPPAPTTSDAKTVEGLGMVSLSRQFSTPPAVSPFGGVAPSGTDAERGLRAMRSREEEEARDLERGAKGPDPFAVQFEPGEDINPKNWGVGYRWWLTCLAGLLVLNSTFASSSPSGIINDMMAYFGFSQEVAILTLSLFVAGYCVGPIVWGPLSETYGRRPVFIATFIVYTGFQVGCALSKNTASILIFRFLGGTFAAAPLTNSGAVLADIWDGDHRGKAMSVFALSPFAGPSIGPIVSGFIHVSGTSWRWMFWILTIFAGVCLAVIVFLVPETYSPKILAKKAARLRKETGDDRYYAPLERADASLKARAHDILFKPFIILALEPMLQAVTMYMSFVYGVVYLLFEAFPFVFEQNHGFNTGEEGLAFLGFFGGGCASVIFFVTVIEPRYLRHAKAVAPEPPRPEMRLELCVISGISLVIALFWFGWTSYSSIHWISPVLAGAFIGVGTLGMFVSLFNYIIDVYLWSAASALAAATVVRSLFGAAFPLFATQMYGKLGTQWASSLLGFLALLMAPIPIILMKYGHQLRAKSKVSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITV6</accession>
    <name>A0A1E3ITV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterility protein Ste20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030184.1">
        <property type="nucleotide sequence ID" value="XM_019177800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194934"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="251"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="753"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1363"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1542" mass="173026" checksum="B246F3EB8438F993" modified="2017-01-18" version="1">MAYPIQPPRPSLDSAIASSDDLDDADTAESIENKLAIERRVQYGAEKMLDVIEKKGGSDSGDQAKVKANITSQLEAANLHIKALETKLEKLRGTPQRARRRQQPRLNGYPSSNSLNPLSSSISSSALASAQRPRAVRQHSNLTPNREREDSSPGGYFTQTTPSRGLPSHPTSSTLASSSGSASASRPRSRSAGEDVLWGDESSWGQSSGRLVEDETTAVLLDSFRMLLMRLREIGRSKGKENENKGLDESCAVLIKLGDLLKRSEALRRSVEVEDTIQHVLPSLCDTSTTKRRAAGYRVLRYILTRRSWANMLSSGLEWLLIRTFTRDAKAVHEREQALRLVRDAMVMPVILPEPERMDSSPMRKRSHSRSSQAREGFHGGMGPLVEEGPFTKVSGDKVSLTDGLVRAIVSVAENPDDAMRTVCMETLVEIGLLDLRCLVRSQAFRTVLLTFKDGPMELGPAITGLLVHSINSPSTRQLLLPGSDLEAVLVGLTEAYGKIPTRLHNKHLESLQQCVANITMLLGSWPGLIYMCHDDRRAIKSLISSLHVPNAEMRDALINLFFQALRIKMPKHMDAFLDGKRLTVYNRTQEATSQQLLDGANEEEEARTLTLVDHFVAMLLTICIESGLLEALIAVIEEGNSTLNRKATLLLGEVLQMANRVLPMQFAAQLQARRLPMSLPQLFAEATDFANPSERIAALSALSSIDSLTRNQTRAVKRAAADKTTVSSLQQDSLMRGQRQVQQVKLRLGLQIEDKQFQQMIVDSGLLLHREHTKWNYEVIMDLIEGPLMNPKRMDEAIRATKFIRRLLSFFHPYNNRFSTVKRTRPNYKWVKLGCSLISTMLSTSEGLRYLMEDKLLRQLLDCFNELDQYVGQPTAQPLFSKDRIENTLTYGYFEMIGTMSKHWDGMRLMEKFKFFTCFYHLSEQRSRDDIIRIIIECFDYTLDGHPRIVLSKALTSSYMETRLYATHHLGRLLHEHPFLMDWGLQLMITQLYDTSMEVCDVAVMYLEEACTESQCLEKVVALRPTLEHLGDVGHPLFMRFVSTSVGFQYLSQAQYIERELDSWLTERNILYVIEAETFVSKTIRPWSSDLVEDYWEYDGLAPTHFLGELTKTPDGCELLKSRGIVAEFAEIVRLHGMEDDDASVLRDLKSALWALGNIGSTEGGLPFLEDEEIIEDIVEVAEHSAVLTIRGTCFFAIGLISSTRMGAEILEEFGWIATRTPLGHTTGLCLPNDVSRFVNIDPWTPPDLREAPLPLPKLHGVEKEIIISISKLSNYVLAAGAMNNLKRIRTRHPRYFSSVTLFHRALQTISTNHFQAPVRRFILELFEVKLDKHELIQLAGLEMNIWRTREGERAQTIAFEEHGNGTPPEEYLGSEAESEEFKERQGRRRSASLPGQFLGPSSLTDNAGARARGITISDVERQRVEDAQAARTSVPSQKSERMSVDNVDDQLKEKKVGWVEAAESLEEVDRDHERAAPLLLAPEIHIEPDRIGSVSARVDGETECGTKNSTVDGQNKAKQHVRGFSVVPADLVGRPSSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU30</accession>
    <name>A0A1E3IU30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_05782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030244.1">
        <property type="nucleotide sequence ID" value="XM_019177860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU30"/>
    <dbReference type="GeneID" id="30194994"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="13">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN92110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="127" mass="13946" checksum="CE025DA185AFEC35" modified="2017-01-18" version="1">MASQPNPKAFPLANAQLTNQILDLIQQAQHYKQLKKGANEATKTLNRGICEFIVMTADVEPIEIVLHLPLLCEDKNVPYVFLPSKTALGRACGVSRPVIAASVTTNEARELNAQIQAVKNEIEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU44</accession>
    <name>A0A1E3IU44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_05806</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030267.1">
        <property type="nucleotide sequence ID" value="XM_019177883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU44"/>
    <dbReference type="GeneID" id="30195018"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="348"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="622"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="847"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN92133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135934" checksum="2D1B9BB79BC637F8" modified="2017-01-18" version="1">MQMLTKFESKSPRVKGIAFHPKQPLLAASLHNGTIQLWNYQMGTLVDRYDEHDGPVRGICFHPTQPIFCSGGDDYKIKVWNYKQRKCLFTLTGHLDYVRTVFFHREYPWIISASDDQTIRIWNWQSRTCIAILTGHNHYIMCAQFHPWDDLVISASMDLTVRVWDISGLRKKNQASNAPLSAEEQIARASQGQADLFGNTDAVVKYVLEGHDRGVNWATFHPTLPLIVSCGDDRQVKLWRMSDTKAWEVDSCRGHFNNVSMTLFHPKHELILSASEDKTIRAWDMTKRTAVQTFRREHDRFWVLTAHPNLNLFAAGHDNGLIVFKLERERPPFSLSGNQLYYIDRKVIRMGDLGTATNQGLCSVRKFGSQYIPPRTLSFNPAERAVLVTSTAEGGIYELITLPKPGAPTSMDGRDVPSDGKRGTGFCALFVARNRFAVLEKGGQTIEIKDLTNTTTKTIKCPVQTTEIFYGGTASLLLATPSSVVLFDIQQEKILAELTTPPVKYVVWSPDGNSVALLSKHTITIANKALAQTALIHETIRIKSAAWDDSGVLIYTTLNHVKYALPQGDNGIIKTLEQPVYLTRVKGSVVYCLDRRAKPQTITIDPAEYRFKLALTRKNYDEVLHIIRTSNLVGQSIIGYLQKKGYPEIALHFVQDQQTRFDLAIECGNLAVALEMARAVDRKEAWDRLAAAALQQGNHQIVETAYQKTRNFDKLSFLYLLTGNTQKLGMMGVIAAKRGNNMSRFQNSLYLGDVKSRVEVLKSTGQYPLAYYTAKTNGLDDTALEILEEAGITEEDLPPPPQNSGHSCIAPPPVVFPQETSNWPLRDLGDSFFDRALANGGIDAGAEEAGEQLDAWAAGDEAASSRAEEDDEEEGDEDEGWDLDADVPVEEEEEEEEVEQDILVGEEAEADLSQGVEAGVSEDDLWVRNSPLAIDHAAAGAFESAMQLLNRQVGIVNFEPLKSAFLQAYQTSHVYIPANASLPPIRYNVRRDPEATEIGQQLPAIPFSLEDIKAKEVSEANKAFGRGKFVEALAGFRAVLHKALVVVVETDGEAEEVAELVELAREYVVGLTLEVERRRIAADPENVVRNLELAAYFANCKLSTAHTQLAVRSAMKVFAEAGNNATAAVFARRLVDAGVAQAQALTQARAVIAQADRNPRDAHEINFDKFTPFDVCPASLTPIYQGSPAEVSPYSGAKYLPEYKGTICVVDGLSRVGAGGSGLRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU71</accession>
    <name>A0A1E3IU71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030129.1">
        <property type="nucleotide sequence ID" value="XM_019177745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU71"/>
    <dbReference type="GeneID" id="30194879"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="49872" checksum="2098C87DF3CA100A" modified="2017-01-18" version="1">MDPQTVFSTRNAFYLRVSNYRIIPLFLYLDERHVNWMTDRVLQLVITGLQSKLPEVLFRAKLEKDKKHKVHVERGEGYQFCYFMRTTSRTEVVLLKNKDVSLRPPTPPPPALSEHPSSKRKSSTRRSATASATPRGRASRSRSRSVTVRPEEDEPVNEQLEQSTKDTDDVHVKPEPIDPDEEDEYGGAQNIKDWKPDIDVSYRGFGTSSVQLVLIIEPYPPLPPSQYAPPASRLSSRSASVVSNYSRARSSQSRQTRGAASRYSSTSLSLAPQGQDSAGRRSEIVANMRNASRAPSVANSRRGGESATPFREDSTTPGPGEAQGRRRMSQTPLFMPRDTPFDEDEEDEEAHEEYLNALRDGRSRLPSVFRPSGETKKGKGKGKRRRDEEDEEDEEDVPESLENIGARLVRNSEIEEGVVRVQGGWEERSAGEESAVIGREEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVN1</accession>
    <name>A0A1E3IVN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030300.1">
        <property type="nucleotide sequence ID" value="XM_019177549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVN1"/>
    <dbReference type="GeneID" id="30194679"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="598" mass="64903" checksum="2520084B1B1EA85B" modified="2017-01-18" version="1">MAATKLKPLPPVSVQFLGTSSGGGPIQSRNCSSLAVDFGNEIWIFDTADGTLGRLHQSSLKVANISRIFITHLHLDHVLGLVPVLTTVMSGVGTTEAETQRVKDQGLKKKANFNIYGPTGLRKMVRSLLQTVHANLSGVFAVHEILHEGEEPSAACGVEDIHTNEAVGSDFRTDSDGVWRDVLQEGNGKGGKGWKVEAGPIHHRIPCLGYVLQEPTPRLSLDTQTLIPLLQSNAAALAERDPPVKHPLSLLSHLTSLPSPPPYQLPSGETISPPEPSGVPPRKIVIFGDCNGGTPNDTFRSMCSDASLLVHECTNAAIPQAIQKGEKGQKVRQRDLESSLVVSRGGVTAGAGKSPSVTHPRPSRWAGEDSNEDTFQNDEEVFADESRAREVIRKAQSRGHSTPNEVGMFARDIKARRVAVNHFSAMFPSPRYSTSHPFPPILSPINSFPYPSPTPLPHTSDPPIPPIPLSSKHSSELHARLIMQSIADQISKHCVSPSVMLEGQEPADICKTGMVVPSRDFMYLPVYSHELTDAEVADVKAHKEVTDKVTREWKVNGGVRLDRGEAADWVGVGNENDVKDARWKFVEEEGSWAAVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVR2</accession>
    <name>A0A1E3IVR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osomolarity two-component system, phosphorelay intermediate protein YPD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030130.1">
        <property type="nucleotide sequence ID" value="XM_019177746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVR2"/>
    <dbReference type="GeneID" id="30194880"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="132" mass="14747" checksum="7B7F4F9DABD770C5" modified="2017-01-18" version="1">METFQQIMDMDEDDGDDDSEEKHSFSKGIVWGYFDQAEGTFKDMEEALAAKDLEKLSSLGHFLKGSSAALGIIKVQASCEKMQHYGNLRDEEAGADLKPADALERIAGLLRACKRDYKAAKTWMENLYEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVS7</accession>
    <name>A0A1E3IVS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose repression regulatory protein TUP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030351.1">
        <property type="nucleotide sequence ID" value="XM_019177600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVS7"/>
    <dbReference type="GeneID" id="30194731"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF728">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR TUP11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="559" mass="61422" checksum="888BD8BBBAC8A4CB" modified="2017-01-18" version="1">MQPPIYNHHRLPPAATPSQQNVLAAPSTTRLNELFDLIRQEYETLGADGSVWKQQRDEYESKVQAQINELGMIRQSLYELEANHNKIRSEYEAEIQRLRHELANRAPGESSVAPGPPPSIPALSHHSPTSELARPPDDRLPYSGGPLPGLPLNGTDVSRSRSPFPNAGTSIIRPPSEARVAAVRPPASASAASPPVHLSDLDPENVSRELRKEGPEWQAVWSGQMRKQLDVTLVHSIEHESVVCCVRFSNDGKYLATGCNRTAQIHDVKTGQRVTVLSDDAASRTGDLYIRSICFSPDGRYLATGAEDRQIRIWDIKAKRIWHLLQGHMQEIYSLDFSRDGRFLVSGSGDKSARVWDIEKGACVFNLQIEDFIHNEHGPIDAGITSVALSPDGNLVAAGSLDTMVRVWNVSTGQQVERLKGHKDSVYSVAFSPDGKCLVSGSLDRTLRVWDLSATKHEVETVPTGKESQKNLGTCQSTLNGHKDYVLSVAISPDGQWVVSGSKDRTIQFWHISTGQAQLMLQGHKNSVISIDLARSGGYLASGSGDTFAKIWKFEQIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW57</accession>
    <name>A0A1E3IW57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leukotriene A-4 hydrolase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030456.1">
        <property type="nucleotide sequence ID" value="XM_019177705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW57"/>
    <dbReference type="GeneID" id="30194838"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="12">
        <location>
            <begin position="485"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="585"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="71471" checksum="36C55A2F0BE926E7" modified="2017-01-18" version="1">MSFTPKFQAEGSPVDRDPATLSNYQQIVTKHLDISWSIDWEKRIFGGSATLQLESVVDDLKEVVLDASYLDVKKVEVDGKTAEWKFGEQIEIMGTGLYITLPSALSAGTKTSIKVTYSTTPECTAVGWLEPNQTKSGKHPYLYSQCQAIHARSLLPCQDTPAVKATYGARVKSGSGLEVLLSALRKEVVDLGDGVREFVYEQPVGIPSYLIAIGAGELVYKPFEKLEGRDWQTGCWTEPDTMDAAFWEFHKDTANFVATAEDLASPYKFGVYDVLFLPDSFPYGGMENACLTFATPTIIAGDRSQVDVVAHEISHSWFGNGIGCASWRHFWLNEGWTTYLERLIIRATHGEQARQLSYIIGRRALVDDLSRLEPRFQRLVAEYKDYEDPDEGYSQVPYEKGANFLYHLEQTVGGLELFVPYMKDYVKTFEGYAITTEQWREHLFHYFGSLKDGDEVLRKMGKVDWDEWLHGDGEDLCVDIKYDDTLSKAVYDLAAKWDKARETNDFSGFSHKDIDSFSTTQLIVFLDKLETYPSFPKSAIKKLDSAYAFGTSGNAEIRLRFYENALKTGPEYAVDASKWVVTKGRMKFNRPVFRLLNEQAPELARKTFEEHKGFYHPIARKMIAKDLGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY48</accession>
    <name>A0A1E3IY48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030624.1">
        <property type="nucleotide sequence ID" value="XM_019177471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY48"/>
    <dbReference type="GeneID" id="30194597"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="313" mass="35572" checksum="0B08A12E4F4182C6" modified="2017-01-18" version="1">MATELAVHRKSTKKVIPIAQIHRRARLWGGCVITDKWSALRFGQVQSINLEDCDCPLPFQWPDHYHDEARAEGPACFAPLYHLTKLSIILGQVLRITSSPQELARTTDCAILQSLTDLDTWSKDLPTSWAVSERTRLPQAGDFFNLMYCAVEFTLLRPFLFPTRPIPAHITYRPSSFLLLNLIDRSEMALDWLSTAEGELYLDVWGITVYPLVTCILMNFYAYNHPSPSPSPTISNPQARALHYLKKGHHIVQLWVQAHAEGWPEDQTSWRTKVGDMVEVVMNSVGAHEAGGGRDRGDRSVDEFWEEVFQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYR5</accession>
    <name>A0A1E3IYR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030478.1">
        <property type="nucleotide sequence ID" value="XM_019177727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYR5"/>
    <dbReference type="GeneID" id="30194861"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="519" mass="55990" checksum="BE96D008772C7C5D" modified="2017-01-18" version="1">MVRLPPSSLLRSSLRAQSRYASSSAHTLRPAGTVTTLPNKLRVATEGVPGHFHAVGVYIDAGSRYESPRNSGMSHLLDRLAFKSTNKHTDAEMTTLIDSLGSQVTCASSRETIMYQSTVFPQSLPLALELISSTIRHPLLLPEELEAQKDAAAYEIREIWAKPELILPEVVHTVAFKDNTLGMPLLCPESQLDVLGEKEVRGFMRDWYRPERMVVAGVGMPHEELVMLAERFFGDMPSSIGAGAGASAGVLHPATGGQIPAGSKSFATASALPVSDDFAELAHARAEYTGGELFIEKPEDEFVQLHIGFEGLGIHDPDIYALATLQTLLGGGGSFSAGGPGKGMYTRLYTKVLNQYHSVDFCSAFHHCYADSGLFGISASVYPQFAGRIVDVIGGQLHALTGSMFGGIDEREVRRAKNMLKSTLVMALESRLTAVEDLGRQVQIHGHKVPVEDMCEKIDALTMDDLYRTANRVLRPASASSRLNYGLGSGKATIVAQGPNLGALGDVKGVLRDRWALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J074</accession>
    <name>A0A1E3J074_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030814.1">
        <property type="nucleotide sequence ID" value="XM_019177233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J074"/>
    <dbReference type="GeneID" id="30194352"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="46"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="53957" checksum="C43F354F8AE4E4DD" modified="2017-01-18" version="1">MNTPPSSFHHGHSPSQQEMSIQHNDDEEMIWEPIISSRAQICYLGLDTNILIKHLNILRTLHAILAALEPQEVLILVPSKVIQEIDGLKHSTALPDIHSPVDVGTLARTANNWLLETHRARREGQRSALRCQSLKERRSRGVVGQNADDEILDCCLYFEEMGGKVALWTNDKNLGVKAEINHVPTIGGQHISLSTILSATGVNFPKELWEQVHELEGHPQSANSVVDGDVHMGAESIQYVCVHTPPPPFSLPISTAPKYFQDLPPIFLPGSSEVQHVHTSPQPAGGVHNYPLLHGGVQEYIAGGNEEGMAIDEMLTTDPIYSTASLGSTSSSTSPPPSTVPNRYTNPPPPAGPRPSKLMLTSLRLALLPSTLALLSNPTYAPHLKVSSPPPTTLPTDKILTTLFDAFSTLDKYCLSKGFEMDDPTRLQLIQATSSVKVVQNYVACHEMGLGGVRRVKTGDMVYALGELKRIMKGLGVGWKGDLEDVLDDFEGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J174</accession>
    <name>A0A1E3J174_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030919.1">
        <property type="nucleotide sequence ID" value="XM_019176887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J174"/>
    <dbReference type="GeneID" id="30193993"/>
    <dbReference type="OrthoDB" id="10425313at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="170" mass="18420" checksum="6F206E9E8F703837" modified="2017-01-18" version="1">MSSTTSDASPSLFSRRKLPAFPRRLSIGRSSRSTNADSSPTTPSLLSPRSPLSFSRSPTVGYAYESMTACTSPPIIQRGTLATESSRATPTRTRSGSTGLETEDRAERDAASTSPEEESCTPSSEETEREAKRKAFLKKQVEEALATVDKNQYLGIHPSERGIPEADEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1F2</accession>
    <name>A0A1E3J1F2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030937.1">
        <property type="nucleotide sequence ID" value="XM_019176905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1F2"/>
    <dbReference type="GeneID" id="30194012"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="247" mass="26957" checksum="918B06EE5EF7BC38" modified="2017-01-18" version="1">MSRLCLEKGKTIPGGSIVLTASVGGLKANAGPIPYFAAKASVISMAQTSAFALKGTNIRVNAICPEFIDASLPIFFYDEPILSQDLNLEIVAIALYRQAFPEISTMSELRQTVQRTARHCRDQGLGMLQISSKDDILPEPFLIDSSSTPGDQQHASAFSYRVASEQLVSLGLRAGYLGPITAYCFRYNFANVIGGAADDSSLATSFGHTVYSSARLRHYTANMPLYDPVLPRSSDRILLPIQFWECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1J5</accession>
    <name>A0A1E3J1J5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030981.1">
        <property type="nucleotide sequence ID" value="XM_019176949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1J5"/>
    <dbReference type="GeneID" id="30194056"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="295" mass="30814" checksum="E3303B08F7D3258B" modified="2017-01-18" version="1">MSNTTLDDTSPFITYGGDTWGTNHTNDALLPKYFDATFHSTTVAGAWARFCWNGTDITLFGARRNNHALYAVTVDNGPVVWFNGFSGPDQLQAPLFASAGLEQEKHQITIFNENNVNATKELIWLDVDYINFIGDAIDCAEVENNTVIPSGTIAPPAGMTESAITSAISSTITSSSSYDIASSSDVESSSSLSSSSEISSSSSSEVSSTISSSIAAPTTLSISSSSTSTSARARTTVIMDQPNVSTNAASSTAEIAGAQGTASSSGAALSARMELGIGQVALIGVMGWYFGRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1K7</accession>
    <name>A0A1E3J1K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031018.1">
        <property type="nucleotide sequence ID" value="XM_019176986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1K7"/>
    <dbReference type="GeneID" id="30194096"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19675" checksum="76B296A4A93DE6C6" modified="2017-01-18" version="1">MSTASNPATYKFNHTMFRIKASLALSTDPKESLAFYENVLGMKKFYESPGGDFTNYFLAFPNGFGDIELTDENVKAQIFNREGVLELCHNWGTESDPEFKGYANGNSEPGRGFGHICVTVDDLEAACKRFDDLGVKFKKRPEEGKMRVNHFPFGAVERDDAVVCEALLHDGVDLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Y5</accession>
    <name>A0A1E3J2Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031200.1">
        <property type="nucleotide sequence ID" value="XM_019176725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Y5"/>
    <dbReference type="GeneID" id="30193821"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="36759" checksum="B398D1A3A1FE599D" modified="2017-01-18" version="1">MSPHESSKFTQAIMSILDTFPKGTEGAGGVGGSRGGDDAFSATQSGGFGFGLGKDRSRGTGFSPFRSGAGQDSLRNVVGFSGRSQSADELIEEYEILAEQINVIQTDVELVEWAKEHVFKAQAVPEPQIASESSKLLGEATGEIEATASATHDLPPLLQFSPVYPKILARTLEVLRKNFNSPHLLLALFHHAQTSSLESYLSGCGTAAYNQVLLCRWESFRDLEGVMRGVREMGMMGVKWDRETNRLVGRVVDEVGRDMLEEGQGSRWGKKEDVLIMLQQLEERVEKNVLDEEKRRDYEVKMKRKDRERKEAEATREATRQAREETDVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J367</accession>
    <name>A0A1E3J367_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031273.1">
        <property type="nucleotide sequence ID" value="XM_019176798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J367"/>
    <dbReference type="GeneID" id="30193897"/>
    <dbReference type="OrthoDB" id="2564760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="36421" checksum="7BADD69E437B135A" modified="2017-01-18" version="1">MPNPAPITSLSFYLDDSLFPSLPPAGGTMNHTDLMGRPRLSPAPPSSVPKPLSHGQLRNKQPAQMAVGQVWQGLQPGQVTRGRSIGAGVGSGHAKAAAPPDAVRGKQGVRRIASLQDHLPPRHSSKSHTRTSSDPQQDPQLAAQMDVKRSIALPVPAEGIPLASPRDTALVKLLTTLQSLTPASRTPDPPPPSPSSATLAPMSLLAPMAIILEALVWERETLKGQEGKKTLPVLRDGSLLQTMRDNTPQELDWRVVNTYIHTFGTLLSSLLPYLQSPHPSDQISELTKSARQYVGKLKKVFGEVAGMYVDGYGFVRGMWDEGAMKGAAGEVGRWGDLFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J7</accession>
    <name>A0A1E3J4J7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031453.1">
        <property type="nucleotide sequence ID" value="XM_019176525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J7"/>
    <dbReference type="GeneID" id="30193619"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000099">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="28726" checksum="F7320AFF3B9779BA" modified="2017-01-18" version="1">MSRRPNVDMATKRIKKEIADLAKEDLGNISLTPDEANILHWKAILPGPAGSPYEGGMFDIDIKVPHDYPFSPPSLLFMTKVYHCNVSSNGNICESTRSLLKTAWSPALSLYKVILSLSSLLTDPNPADPLVPPIAKEYKSNRKKHDETAREWVRKFAQPKQAPKVAPKPPIQSRASTASIPRRAISRPIPSSESPAPPAQIAGTRRGPPIELGDSEDEGDIEVVQGSSRVNGHAGSGGGQGGGTGSQGRGVKRAKTSGGGNAGDAIVIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4N9</accession>
    <name>A0A1E3J4N9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S small subunit ribosomal protein L33-b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031493.1">
        <property type="nucleotide sequence ID" value="XM_019176565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4N9"/>
    <dbReference type="GeneID" id="30193659"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12421" checksum="505E5F8F34EC43CE" modified="2017-01-18" version="1">MSIHRLYTKGRIIGHKRGKRNSRPNQSLVQVEGVDSQEAARAYLGKRVAYVYKAKREINGSKVRVIWGRISRSHGGNGVVKTKFRTNLPAKTFGASCRIVSIHWACDEAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4P5</accession>
    <name>A0A1E3J4P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031487.1">
        <property type="nucleotide sequence ID" value="XM_019176559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4P5"/>
    <dbReference type="GeneID" id="30193653"/>
    <dbReference type="OrthoDB" id="2576525at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="33544" checksum="C74D093D4DABEE34" modified="2017-01-18" version="1">MSLSSSTLSLKFMQRGKAPAGNATPSKNTNKAGQHPTPSASAGPSTSNSPAPASLITPNSTDRPEEVSQTLAREEAAKWYIPRPNKPATAGAAPKKGDVRVEYEASYAPFLPGFDDQDSDEEDEDAGERTAGGGRMVFGGFGKPKGKEKAEDGDDEDAAMDSEEEEVQDKRAKPRVEKRKSFAKDKREQKVPAQQPPKTFLRPAMSPPPSNPKSSSSRPKSSTQSVSSLKQEPNTALSSKKHKASKRPAPPESPQTSFTGSGAGVKKAKIEPEGGKQKVKKEKSGGGGSLDDREKMMKAQKKAEKRRAKEVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6J3</accession>
    <name>A0A1E3J6J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031720.1">
        <property type="nucleotide sequence ID" value="XM_019176310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6J3"/>
    <dbReference type="GeneID" id="30193401"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69985" checksum="EDDF0C915D756A02" modified="2017-01-18" version="1">MLAHIPPEILSHIAFHLALASPDTLLATPNVPLLQTCRAVADTLAPSRNYRLYARIYRACFDTDAAERRMGSGYDAGPAGARYKKLTVDGGKKIQAQGMVAELQKRLGSLARLRRMVQQGDVRDVVDSDLWVLYFMLIENDGKNIDLLFGPTALVDLERFLELYHEQHLLEAAVAPGYPEETVGRSLAMWMIWFVAGSGPSDETEEQREERQFVLRPYVFAAPRYDAYFAPWTLPSLPISPESAALLSEDLGGSNPYVADLVPRSRLEVIQAYGRDVRICAPHISHAAIARFFYRRLGEEIEESKTNVVVAPFMSLLGEASRTASTSTTPAGPTPAGPTPTGPSPASTAPQTPLLAPFGAPSTRMPLLTSSAAHDAEFYRLSLCYDPTRTPGMPRPAWRGTFEGCWEGTFSFFDFEAFKEMLSGQARALYEGPYGEQAQVWKIKETWVRREGWVRKEAVDKGKGKAKAKGEEREVEEPQSPNTAVSGPMLNAGFPSDQVSPTFPSLAPFAAEQVTVQETIQQQLEAMNGYEQVPEHELDEMMGADDGGEEADLELLLTGVGHSAWGNFILKGRVRAWDGMASLVKEYAPDSRGKWIYRGYVMAGSIFVGRWRDTYTPESYVGYEGTFILNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S2</accession>
    <name>A0A1E3J6S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031794.1">
        <property type="nucleotide sequence ID" value="XM_019176384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6S2"/>
    <dbReference type="GeneID" id="30193476"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="416" mass="45525" checksum="BD94B2B703F272B9" modified="2017-01-18" version="1">MTTTSPPPKGNPANAPATPFPKPTQPLPEELGAPLEDSLDHIVSNSKAVKGSHKDQLAPSEIREDAVHSHGAAAKKWVSKFFPSEETLDHLFAAQHMGNYVIDRVSGKKIFETMPIYVRIGMHLLFVSGNSYMSYKSVEKLLQDKSIKQGKTYDRTGPDVREHIEAFIATYDLPLNELLVQDLDQYPTFNSFFSRRLVPTARPITAPHDPTIVISPADCRVTVYETVDLAKQFWIKGKQFDIPSLLLGDEAEQANGKASLIISRLAPADYHRFHSPVEGTIVGIKDIEGELYTVNPQAINEDLNVFTLNKRSVLIINANLGPGRETVPVAFVAIGAMLVGSIGWSKTPGQKVAKGEELGWFQYGGSTTICVLPSRAGLQFDADLKENSLKQMETLVQVGMEVGKVVPIVPTGAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8X9</accession>
    <name>A0A1E3J8X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional activator HAP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031909.1">
        <property type="nucleotide sequence ID" value="XM_019175996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8X9"/>
    <dbReference type="GeneID" id="30193083"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="253" mass="27733" checksum="024C195064D9DD50" modified="2017-01-18" version="1">MNPSYFLPNAYDDGQGPSSRQYDDGSASESDASLSPEPLYPHNPNEHYSHSQPHHFPSHPQQPHEEQRPPLQTGPMVAPHQDLDSFLESFWTRQMDTVEGETPDWKSYNLPLARIKKVMKSDEEVKMISAEAPIMFSKACEIFISELTCRAWLVAESNKRRTLQKSDVAAAIAYSDMFDFLIDIIPRDDGGNGGTGAAGPSGNGQGSGTQTGGQGSVAQEDGVEEEEGEGEPYEGTEGGEEGEDLYGEYVQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J981</accession>
    <name>A0A1E3J981_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03971</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032009.1">
        <property type="nucleotide sequence ID" value="XM_019176096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J981"/>
    <dbReference type="GeneID" id="30193184"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="848"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110428" checksum="EED0733A1D7E4CA8" modified="2017-01-18" version="1">MSLARRLPRLALPAARPLSSLRRSSTTATQPLRSASQSFPPAATSVFTPLDTFLPRHLGPRDADIQTMLQTLGHNTLDQFVAATIPSEVRIDALTNAESSKGISALSELELRRRAEQVAAMNKNVKSYIGMGYHNAIVPPVVQRNVLENPAWYTAYTPYSPEQSQGRLESLVNFQTVAISLTGLPIANGSLLDEATAAAEGMAMCLASVAKPKFTKGKKVFLVSPTVAPQTIAVLQTRASGFGIEIKIAESNAAFASEVESLGEEKLMGALVQYPDVNGEIGDWEAIAKGVKSKGAKTVVATDLLSLTMLKPPGEWGADIVCGNSQRFGVPAGYGGPHAAFFACTEDLKRKMPGRIVGLSKDSAGNPAYRLALQTREQHIRREKATSNVCTAQALLANMTAMYAVYHGPEGLRRIAGKVHSLTRILSESLTALGFTITNKTFFDTLTIDVSSAGVTAADVHAASVKAGINFRPVDDKTIGITLDESVGPLDLTDIVNVFYAVKGESAIEPDVLESLAQKLELNSSSVSAPIAHFARTTPFLTQPVFNKHHSETDMLRYMMYLQQKDYSLVHGMIPLGSCTMKLNSTSSMVPLSWKEFGGIHPFAPVDQAKGYEVIIKELENDLSLVTGYDATSVQPNSGASGEYAGLKVIQAYHESKGEGHRDVCLIPLSAHGTNPASAAMVGYKVVPVKALEDGSLDLADLREKADKHKDKLASFMVTYPSTFGVFEEGIEEACKIVHDNGGQVYVDGANCNSLVGLTSLGRVGGDVSHTNLHKTFSIPHGGGGPGVGPISCKSHLAPFLPTHPIVATGGSTPISAVSAAPFGSASINTISWAYIKMLGGEGLTNVSKIALLNANYIAERLRPYYNVRYTNSNGRVAHECLIDLAEFEKSAGLKVSDFSKRLQDYSFHPPTAQWPISTCWLIEPTESEPKHEIDRFIDALISIRAEIDEITSGAQPKDDNVFKNAPHPLSLLTADKWDKPYSREKAVFPVKSLRRNKFWPSVGRLDDAAGDLNLICECGSVEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J986</accession>
    <name>A0A1E3J986_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032025.1">
        <property type="nucleotide sequence ID" value="XM_019176112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J986"/>
    <dbReference type="GeneID" id="30193200"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="9674" checksum="AB18930F57688315" modified="2017-01-18" version="1">MTSNTNYTSVDDSAGSQAASGLGDKIKGSWNVFHGAGEGIRGNVNSFLDNAGEQLQGNDAAAAAQQSSHRGERPAGVASKGADEIQKGVEQIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JAZ4</accession>
    <name>A0A1E3JAZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031888.1">
        <property type="nucleotide sequence ID" value="XM_019175975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JAZ4"/>
    <dbReference type="GeneID" id="30193062"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="810" mass="87270" checksum="2969B5C90F461CAA" modified="2017-01-18" version="1">MAQVIPPISLTHIFLLSPISPPRTRPTLPPPSLPVAPDLRRLPIFIINLHQTSLPSDSGAAPSVEDIQDRLPSICVDYLSHDWSEEDVWASWRNMTRHKHEIANGVRLENASWRTWNKQRNKLKTISPETLNWLKDSDVTWLYGPLHTANVEPVRPLKVSSTDDRLGIDRPNPDAKKPILKHRTLSEMLTIASPSSPGHEGSDGDHAQPSDDEDRPKLLLQTKSDTNILRNRSAVLARQKSPDRHHNHNFDKSPSDENGPTSPTDSQQNSSKRHISFNTFVEQCIAVSDPTENQQHHQQQQSQSNSPSDSDDEMLEIKPSSLSSSSRSSRESRPSLSRNSSTGSSEHLTIAMIAPTMLKTGPGHNPDLPCVYAPPSEYQSPSDDRTDSYDFPSPQIDPSTGKWQEEDEDESGRDSGPYDYFHGPNLGGSEQKKGQAIPNNSGPYGNGRPPSGSPPSKYRIAVDQERNDASPAPSSNPSANVGSVTSPPQRGILKVRPPGQVPPPEPASPPLAYFNYTPSAATGIGGMRGTSPYDQAGPTGSPVTSPGAEERGRGRTPSRERLHDRSSSRGTSTSSLSSSSSRSPTENTAGGVSLRKVQTPPQLDRVQEESHNSAGGDQTPRKGDGVKPKGIDLPEAQPVEPGSPSLATPAEPDEKLKDYVADRSSTPTPHSSPQITFRPLKDTSPASLPHTSTHNKARSPDLPKADPPTSVPSADKSNNSGARATIAHVGTNAQPTLSQPIEDDDGASIMGRAANIASTAKDLLGSLWYGQNEGQGQGQGLGQHPYQQQTQPLPGAQVHGGNARRRAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBH8</accession>
    <name>A0A1E3JBH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03834</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031873.1">
        <property type="nucleotide sequence ID" value="XM_019175960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBH8"/>
    <dbReference type="GeneID" id="30193047"/>
    <dbReference type="OrthoDB" id="2575827at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN97271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="42082" checksum="AB7053E4EC6C07CF" modified="2017-01-18" version="1">MPHSNLPAHFNRILDHQYFLFPPSSMRHRNPNLSSNTPYLSPQSQPGDFDDGSLPQLPSTQPTMPEGAKVAPRGCQTTSPYLSPPHTAERSLAPCLPTPQVSNARHGEQVNHFPFYHTHPSSWENVGQYRHSAAAIQPWSSPVPSTPGPSHPAETFASVAAPSTQPSYHQWGYPMPETILPFDYSHQNVATVQTSSTVTKRDDSSAPKRESNASSPSDEGLVTKGGCHPCAICAKRFTRPSALSTHMHTHTGEKPFVCPICLRDFSVQSNCRRHVRQTHKAKDARARLEAEEAAKRNGSLYPPGTLPLSLAPSNHSVASSSQSRNNTSPIFPRDTASMYGSVPFAGGLFQSGSTTTSTDLQPAVDPRAAGGSRGNRREPRDRRKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBS5</accession>
    <name>A0A1E3JBS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032154.1">
        <property type="nucleotide sequence ID" value="XM_019175664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBS5"/>
    <dbReference type="GeneID" id="30192748"/>
    <dbReference type="OrthoDB" id="2573978at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="327" mass="36147" checksum="F8CF3B1B10B9A536" modified="2017-01-18" version="1">MASTPDTASSEGPSPSPSFDRQPTPDPQLVQTYHDLMLSTLPQDALPQPTLVAQEASNPLAGDEVDEEDNMVVTETGEKRSMTKGEKQNAKKKRRKEREKAMKMEIERQMAEAQAAQQGDAGKVEVREEKLVDFRLFSTCNVKPVSLLPAPEVYPIPANPRYQPLPAHQQARIHQLAVETAVESDNLGGYPDHPRWSRTDVTPRDFSVSHQALPTLPDMFIGTLFEDAVRTDQPSKPVAKSKSTAKPISTIPLASSHTSCPAPTLPPVSKKRTRRGRRAIPSRTAPHFWAPPKGLGGKARGYAWGFRDSREGRREEGWGTYIRGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC37</accession>
    <name>A0A1E3JC37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032279.1">
        <property type="nucleotide sequence ID" value="XM_019175789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC37"/>
    <dbReference type="GeneID" id="30192874"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27162" checksum="AB3AA8756D2274E7" modified="2017-01-18" version="1">MAAPGGGGAYSFSLTTFSPSGKLVQIEHALAAVAGGTTSLGIKATNGVVIATEKKAPSVLLDTSALEKVAPICPNIGFVYSGMGPDFRVLVAKARKIAQAYWKVYGEYPPTKVLVQEVAAVMQKATQSGGVRPYGISVLIAGWDAHRGQSLWQIDPSGSYWAWKASAIGKNMVNGKTFLEKRYNDDLSLEDAIHTALLTLKEGFEGQMTEQTIEIGVVTVPTIEQMQEKPGERLPPTFRKLTEQEVRDYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCD5</accession>
    <name>A0A1E3JCD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonselective cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032379.1">
        <property type="nucleotide sequence ID" value="XM_019175889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCD5"/>
    <dbReference type="GeneID" id="30192976"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF6">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="263"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="79009" checksum="4844C47156E5D213" modified="2017-01-18" version="1">MSGQSDAASALFALIHDLHHTVTATIDTALDWDQLNSPPINYTLVRPLVLRYAPKLDEDKYNTNGSSIVVPPNQGGELGVDRSAPIPASGPSLGQVLYALMANRIQFITLSAGDMSSAMVQATRAAFCELLAIRILRAYPNVQDEAALVGELVYSHCAFDGAPDQIWESLGEDRKDVEEMTSSALELAIVSTSKNLLALPLIQHLIKLVYSGQLIYSPESSRSIISDSYVSEQVYMYNPYEAGWLDHSRLKVPKWRKSMEFASFAILLALFVATLAWRDLNHIAVVEIVYMVFSFGFMLDEFAASKEHGWSVYVANAWNAFDLSYIAIFLGYFVLRILALVSHSPKTSDLAFDILACAACIIFPRLVFFVIKENVVILALRGMVTTFLRFMLVTIVAFSGICFCLWTLGRETWTVRQIVWLMAQIWFGSSNLGFSSSESFHPVFGPIILLSYAALCNVLLITMLIAILSAKFAAINQNAQQEHLFQRVVKTVEGVKSDALFSYLPGINILALGLLVPISWVVSARTLHRVNVFAIRLTSFPILISISAYERYSYHAKQSSWLGGGSEFLIASVFELGPPVAPEDSDSQSGFTTPKALGLTSLPTTDEPGTMTQAEEAKLKQAQQVQKKKKKDAKKEKSYDSPLAKLFGRPSVFASSDESPTKAEAGGKSVGDKEKEIVENLANKEEVEALKKELETVRESQLRMEEMLANVLAGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF23</accession>
    <name>A0A1E3JF23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032555.1">
        <property type="nucleotide sequence ID" value="XM_019175452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF23"/>
    <dbReference type="GeneID" id="30192535"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="106" mass="12249" checksum="B18EBAA955A1F527" modified="2017-01-18" version="1">MPRFLVYAPDYPDYLEKRLAVRAEHLARGQIDTDSRLVLYSGPILPRPGTKAREATLPEGVPNIAGSFMVYKMDSLEQVWNRLKEDVYWRAGVWDQSRVIVEELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF66</accession>
    <name>A0A1E3JF66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032561.1">
        <property type="nucleotide sequence ID" value="XM_019175458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF66"/>
    <dbReference type="GeneID" id="30192541"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="200" mass="21776" checksum="D160B52F6BB9787F" modified="2017-01-18" version="1">MSAVPSLESLKDPSALTTLLALLFEPSPSLHSLLVPSVHSQLATSTRLESYNIIIDLCQATSSRWSWQEKADFISGHPMIGEVTGLSKLSGKEQGGGGATPKEVLDRLAHLNQLYCKVYPGLRYITFVNGRSRAEIIPDFESVLGLPASTGDPNEPPIDSEEVEKMVKAPESEEWKKECSRGLADVWLIGRARLSGMGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHY9</accession>
    <name>A0A1E3JHY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032608.1">
        <property type="nucleotide sequence ID" value="XM_019175505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHY9"/>
    <dbReference type="GeneID" id="30192588"/>
    <dbReference type="OrthoDB" id="2533496at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN99531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="115" mass="12648" checksum="BEF6A9EE30D6F75C" modified="2017-01-18" version="1">MAELGISPTDTVASDSSIEINDAMFCEHGLEVCKSCEFDAREDNDFMMGVDAAPRGPLELPAHYKNQKDGSYTCKAHGNPNCKSCFSWKKQIVKLHKEGKKAASKKKTDSGTNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI11</accession>
    <name>A0A1E3JI11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032721.1">
        <property type="nucleotide sequence ID" value="XM_019174989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI11"/>
    <dbReference type="GeneID" id="30192061"/>
    <dbReference type="OrthoDB" id="2576477at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="46463" checksum="2A2F7622FE21399C" modified="2017-01-18" version="1">MPPTRLPRSPSDPIHLSHRPPSPSPGPAAGQQIYVLTADGSSLFLVDPSKPRGGEEPPPYASFPVQPLPLAGGDDAEADADVDVEAEEPGVGVRRVEFPRVHEEEEGPHRHRARTLSAISNQERYRPRTFTFTRPPASRRARSALSTPEPRTAWLVDVPDVPDETTPLLPGPGRDLESAPIIAAADEQAGWRGRGWWKGVWCGELEDGEEDTRVGWGEGWKRYWRPALLVWPWLLVGTLAGTALLITLPLGAIVWWLTLIISRSAARLETIMQLHYHTPLPPGKTAQYHPIFYRPLPVPRSSSPYYNPLPSPSSHPHPHPHPYHTTPSSPLPPTSDPSPIIWDKRFTKNAYAMFLDHYSYSALSYFLLIKPLLTLFGTIMCILVLAVLGVGTLGVGLPVGMRIVRRWGRWQGEVALDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI48</accession>
    <name>A0A1E3JI48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032753.1">
        <property type="nucleotide sequence ID" value="XM_019175021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI48"/>
    <dbReference type="GeneID" id="30192093"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="278"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="520" mass="57135" checksum="61DDDDE2C6AF0390" modified="2017-01-18" version="1">MRELADLLTCRALIIRLQHLISTSISHSSPQSDLLAHAALLRLIPLIKSTTWDLDIYYWAVSTLYAVLNPGKRWKTNDVAMEVDGADGAEDDGSGMGRGGLYGKIIPPGRGREEDGFPDEKWVDDAREAYHKEYTRLDVELRGYVSNLIKESIRLTQLALAQLALKTGNINEALKYFSGAREHSVSNQHNVDLGVSILEACLAFNFPGPLTGHIAKLESVLDRVHPHPSGPAGKPTKTNMTTTLADLREREVADARSLATRRSVISRIRVGRGLLALSQKEWARAGREMNYIDEEAGGLGDWEGKAISTGDVALITAFTVLASSDRARIQRLLLDRQSFRASVGDNLPWVLELVQSFVGGKYDKVMSILHDAQPTLLLNPFLAPATRNLIHLIQTSAITQYITPFSTISLPNMASAFTLDYPAILEIVEKLVSGGDVKGKIDLIDGVLMVEEMDVRGEMFEKALGAGKKAAEMSEATVLKMKFAEAGIIVDPRPKVDRTQAPQEPSYDDYTSHKGLELLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIB0</accession>
    <name>A0A1E3JIB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032813.1">
        <property type="nucleotide sequence ID" value="XM_019175081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIB0"/>
    <dbReference type="GeneID" id="30192154"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.10:FF:000006">
        <property type="entry name" value="Probable translation initiation factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32372" checksum="A87F0B4580F799C3" modified="2017-01-18" version="1">MPPLPVLLRTLLRPSISRATLAPRYASSHAPPTSTIGLRDSAIPHRTVRLATPTGLSQPQSLSSILPTYDPSHHSLILVSTDGPHAIVKLVSRAEEREKEKEKEDKERVKRKMGMEEKEVQVSWQSAKGDLEHKLDTAKGLLEKGDRVQVVFANRKRGDPVGDAQKKQVVDLFDAALGEVGKKWKNDDVNKGLWVLYYNPLDSVRQGVEKKVLDAETAKRREKESAKEEKLEARRKKEERRLKRAEEMEEQRIAEARKAEEDYRRRQEEAKKRKSSSFGSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIS4</accession>
    <name>A0A1E3JIS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032976.1">
        <property type="nucleotide sequence ID" value="XM_019175244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIS4"/>
    <dbReference type="GeneID" id="30192324"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130385" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15685" checksum="6D3C5294F8FD3146" modified="2017-01-18" version="1">MYHPKALILALLFSLSLILAAKSSEQLQIGVKYVPEECPLKTRKGDKLSMHYTGTLAKDGSKFDSSLDRNQPFEFTLGAGQVIKGWDQGLLGMCISERRKLTIPHTLAYGERGHPPVIPPKSTLVFEVELLGIKNRHVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ83</accession>
    <name>A0A1E3JJ83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032888.1">
        <property type="nucleotide sequence ID" value="XM_019175156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ83"/>
    <dbReference type="GeneID" id="30192235"/>
    <dbReference type="OrthoDB" id="2564702at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51047" checksum="EC09B5B3F7EC37F1" modified="2017-01-18" version="1">MAIQFLKRTRSRPALPYDLLHIILTELKRTDSLGSLALLQRCNSDYYDIVTPILYTHVRIHTDDQLQRFLTLPIEPRARKRSKGLSLLSSKGSKSPKSGLRSRSGSLIAYEKKLRAFQKVKTITLDIYPSRTSMKIAGKLPFPLFAETLTFTPSALLSLHSKLLRSGAPRILATFWAGHLSSIVQPQRVVVDYSTIDIRSHLAGEKKASWWDTIAGLSSALQQWERLDQVTLVGEYWALLVPSPGVEMKVIHTVFEPKEDAEEDEGALTEGEDSDGNPEVPLQQTIPGGPAPPPHMVNLPLNAMPVPIPAPAANADEDGQPPLSFRAKLLMDRRDALLLGLRTSYQIVQHAQYQARTQPHHLTSYVPEHFIHKGSRNVREVRWVVEGFFPPVGEEDENDEGDEETEVVEKSERERREVVKWLVTELDQQCPQLVHECGRMVDERVELSCISWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKW2</accession>
    <name>A0A1E3JKW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_03084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032949.1">
        <property type="nucleotide sequence ID" value="XM_019175217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKW2"/>
    <dbReference type="GeneID" id="30192297"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="109"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="214"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="447"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO00757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="596" mass="65616" checksum="9F6F031509347731" modified="2017-01-18" version="1">MFGSVFSVSGPVVIGENMRGCAMYELVRVGHDELVGEVIRIEADRATIQVYEETSGVTVGDPVLRTGKPLSVELGPGLMTNIFDGIQRPLKSIQEKSQSIYIPRGINTDALSREIKWDFNPASLRVGDHIAGGDIFGSVYENSLVDNHKIMLPPRAMGTITRIAEKGSYTVDDIVLETEFQGKTTGHTMMQLWPVRAPRPVAQKETATYPLYTGQRVLDALFPSVQGGTTAIPGAFGCGKTVISQALSKFSNSDIIIYVGCGERGNEMAEVLADFPELTLERDGREEPIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDQGQNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLAGFYERAGKVSCLGSPSRNGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLSKTLAQRKHFPSVDWNVSYSKYLKVLDPHYEQHNPGFIDLRTRAKEILQKEQDLAEIVQLVGKSALGEGDKITLEVARMLKDDFLQQNGISEYDRYCPFYKTSGMLKNFVAFNDYSQRAVETGDFTFAQIRDAASDVTYKLSQMKFESPNTQSEEDIVNKYEALYNEIGETFRTLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLP8</accession>
    <name>A0A1E3JLP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033061.1">
        <property type="nucleotide sequence ID" value="XM_019174682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLP8"/>
    <dbReference type="GeneID" id="30191748"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="81" mass="8382" checksum="9BFD913B742199B0" modified="2017-01-18" version="1">MPLTDALQPPLTPAEKAVVKDYGGWTNFNHAMGLKPYDSGDAQEAVAIARAFAPDFAQHQASQSQGQGQGKQGGGGGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLX5</accession>
    <name>A0A1E3JLX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S22-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033110.1">
        <property type="nucleotide sequence ID" value="XM_019174731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLX5"/>
    <dbReference type="GeneID" id="30191798"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO01858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="17927" checksum="2BE229E59ABA83C4" modified="2017-01-18" version="1">MEEEGSGTMEEIEGMESNVEMKEGRGSTKNQERRHTDEILQNNIVNAERRGKRQVLIHPSSKVVVKVLSVMQKHGYIGEFEVIDDHRGGKIVIQLNGRLNKCGVISPRFNVSVDSIENWVSQLLPARSFGKIILTTSAGIMDHTEARNKHVGGKILAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM18</accession>
    <name>A0A1E3JM18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoskeletal regulatory protein binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033171.1">
        <property type="nucleotide sequence ID" value="XM_019174792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM18"/>
    <dbReference type="GeneID" id="30191862"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="653"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="801"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1173" mass="127722" checksum="3023EE0B17C38E53" modified="2017-01-18" version="1">MSRNISYPAPHPAPYIGQPRASSSAGDGYYTSSSSKDRHARQTSASRSAYPNALDSSITRLLVTTKQLLQGLEQWSQGIISETDVSDIYVRLGNGFETCVQAFNRVSIETSELSSIPQDLRNCLEQCLSGEQSRETLELYLPEIRQIIYNLLQGLKQKQSQYKRMMQDKGRSYEPSSSLTNLSQTSQAPAAPAISQPIAQPAPNPPHRNASREYPDDPRLSGRSGTSTASASPSMIQQQLPQGYPSVSPIPTQRTPSNPALAERERRPMPSRPPPPDAFRPARPPGPRRPSSPNPPHQDGIHHVMARGGSSDSQSQSSYDIPVISISPGSRSSSGTALAGAPSAPPLPQSVAPQPKPNLSINTNKPTPPRPDRFPRDSFGRPVSRFSMDSEASVTSPVNEARASVTAGKMDAVPEEEEKRGSVDLRRRPARTSFDRQSRASGSSERHSQQPSSETPALPSLELPGQINLQSSTPPADQHNFSSLHPNLPSPESLPIPEVPPGTRATLAALGRSDVLERRASKRFSSFTMANFDPSSPRASPQRPTRRAAQQTMREREQQQMQQTSAVTPLPEGVGLGVGVPDRAGGSRGGSPNLEQVQEVGDEDVTHSTIEPSSPTGSVRIVKTPPPSSPSATPRPPSYPAVPPRDPNKLSVFLQIGRKTKKQTLDLPITLEQLKLVFMERFEYDPGKEDFPDVYIRDKDGMEYELEGIEDLREGCTLCLNIEPLDQVKLHIDSTFATLMTEMKDLRSALAKEKETTKRLSVLAPPALKEDFALSPSASPNQVAASTASLPAPTPLVVGPTEDHIRQLQEQHDELEILRRELAISRQAHSENLEESTTTITALRDELAAMKKITAVNPNSNRALVDKSKAELDTQFTDTIKAVEDITDIIDAARIDAYKRYVTPSKRQLDDIRAELAKSTQMVDDFAKAVKLADPTWRGTWQSELHRVMEEQKLLNHQIKLVGDLKKDVEDAKSMWGFVENFVEQRATGNRPVKVRVGADAGDETSGGGDISTLLLEIRNKEADPDSRLRAIEAQQRMREKERLNKVDDFEAELRGFVGGRKLKKTGGAEEADRLRLRKDEVMLRAHLTGGSGTATPSTGGKMVPQTTGQSVQSGRGPLSPQGTGTSVPLVDPASVSLPNTPAKSDDLGSAGGTPIKNESGQSELPVDSEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG0</accession>
    <name>A0A1E3JMG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033313.1">
        <property type="nucleotide sequence ID" value="XM_019174934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG0"/>
    <dbReference type="GeneID" id="30192005"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO02061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11667" checksum="DF6D7ACDE6A5B6B6" modified="2017-01-18" version="1">MHPTGIALRRSTWKGPFFTAFPSLSHHLKSSTPIFTKSRACTILPNFVGIKFMVHNGKDYLPVTIAEEMVGHKLGEFSPTRRPWSYRWVAKRITVFREFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP07</accession>
    <name>A0A1E3JP07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_02595</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033119.1">
        <property type="nucleotide sequence ID" value="XM_019174740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP07"/>
    <dbReference type="GeneID" id="30191808"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013040254" description="alpha-amylase" evidence="19">
        <location>
            <begin position="16"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="20">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="44"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODO01867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="61037" checksum="CF536EC9C9DDC482" modified="2017-01-18" version="1">MILLYLLLLLPLAQSLQQAQLRDRSIYQLLTDRFARSDNTSPYCDVTKKEYCGGTWKGIEERLDYIQGMGFDTVWISPVVANVELEGRGHEAYHGYWASDIHQLNKHFGTPEDLRDLSEALHKRGMYLMVDVVANHVGAQNLESFSPGPHYGPFTSADDFHKYCIPEWDKNNQTEIENCWLAPEMPDLNTESPRVISLLNTWISNLVQTFNIDLIRIDTVKHVRKDFWPGFVEAAGVGAMGEVLHGDPSYLAPYQRESVGSLLDFATFFHLQRAFENTLGSIGELRKMITEVHQLFPDPSSLGSFLDNHDFPRFAGKTRDPVLIKNAMVYPFVKDGFPIVYSGQEHNLEGGNDPFNREAIWSFGYSTDTEKYTLLQTLNKARSRASTSPSFPALCKPYQHINHTLAISKPPLLSVLNNYGSYQVVNLHYIPPEQTGYRGELAVVDVVSGQVFGTDPKGGLSVPIVNGEPRVFLPLGVWKGKVEDGEWQRKEVEEKSELGLGLGMGQGLGARSSSRSPPGSPRLATSLGAMVSWLGNKNGGGSGKGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRD1</accession>
    <name>A0A1E3JRD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033456.1">
        <property type="nucleotide sequence ID" value="XM_019174404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRD1"/>
    <dbReference type="GeneID" id="30191465"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="157" mass="17499" checksum="CDF88E72C26781B8" modified="2017-01-18" version="1">MTDAANTSSGPALHQAVDQLTAAAQSGYNVYQNRDLFQERALRDVTMGSNESALMLDPNNPILVRDEMNAQKDYFRRLKFTYLEQGAKRHFLASITGEEPQRVEPGENEELEASNAQKKAELKAVKTNIENMRKETVALAEQNAKRKSNYLPADGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRF0</accession>
    <name>A0A1E3JRF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B2-aldehyde-forming enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033454.1">
        <property type="nucleotide sequence ID" value="XM_019174402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRF0"/>
    <dbReference type="GeneID" id="30191463"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130516" description="B2-aldehyde-forming enzyme" evidence="3">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="33259" checksum="1A8879CF91B2ACE6" modified="2017-01-18" version="1">MLFSALFTLALALPAFSAPVEKAVALEKRRTTYSGQATFYDVGLGACGGTNVATDYIVALNTAQYGSGYPGPHCGKAITISYGGKQVGATIEDECPTCAYGALDMSTSLFLNFATENDGVFQMTWWYDDDDSSEETTTSSKKTSTYVAPTSTYTPPTSTYTPPTSTYTPPTSTYTPPTSTYTPPTSTYTPPTSTSSYTPPTSTYVAPSSSSSQSPSSSIEPSTSPSAVPSTISSSAAASSSSASSAASSIISTSSFPDVVVVQTNATVASSTGVNSTRSGSASASATASAAPLESSVSELAAFGNLVTLNQAVVNLGRILVVGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRG1</accession>
    <name>A0A1E3JRG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033520.1">
        <property type="nucleotide sequence ID" value="XM_019174468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRG1"/>
    <dbReference type="GeneID" id="30191529"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO03469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="168" mass="17679" checksum="11FB3879FEA6566A" modified="2017-01-18" version="1">MFAARLAPALRALPRQASAVRIARRGYAEAAADGKLSLSLVLPHQSLYSATGVTQVNIPAATGDMGILANHVPSVEALRAGVIEVIEENGQPSKKWYVSAGFATVHANNTLSVNAVEAYSLDKFSPENIKAALTDANRVLGSNAPESEKAEARIEVEVFEGLQAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRV5</accession>
    <name>A0A1E3JRV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033669.1">
        <property type="nucleotide sequence ID" value="XM_019174617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRV5"/>
    <dbReference type="GeneID" id="30191681"/>
    <dbReference type="OrthoDB" id="10404352at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="41803" checksum="7F0ACE55A429AD64" modified="2017-01-18" version="1">MSSLTPERFARLHPVHHMIFDYLSQSSPYLVLRLNKYHRRRIIPNLYHTFTITTKSLGAFDCGLTGEDPLLPLAINQVKVLRVVNTESAILFEHLRLRDDERWVFPLHLRDDERGVFPLRLRDDERGVFPSELKVVRVEFSWAVIRDGYFLRIQGRLGDVGKYTILEEVARSDHLAEALVHVDCGDEWASHDSNELGCIPWMFHDRSVDINTTIVLHAPTHGRIYFPLGERLPLPSPSTLRFVLWSTPEKKEQIHPGDPRPIPIPPPGVLEDFARFIALSTAALEQDWVEASLYPGEVLEEGFVYPLAIEVVCPSPIYVEELARTFYRPDQRKAKGFDWAPRFRKLDRELVDNYDLWSTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRX3</accession>
    <name>A0A1E3JRX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">L198_02480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033680.1">
        <property type="nucleotide sequence ID" value="XM_019174628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRX3"/>
    <dbReference type="GeneID" id="30191693"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="336"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="443" mass="47997" checksum="4464D2A14248FA7B" modified="2017-01-18" version="1">MPELQELASLPAHADPAWTVAFNPTRPLLASCSTDRTIRLFSYILPSSSPSEGLPGKDDPQPVFSLMKVIETEHKRTVRSIAWSPDGRTLASGSFDSTVGVWEEVVPTSDDEDDGDEGVYKPEGSDDDDVGGNKEKEWECVTTLEGHESECKSVGFSSDGALLASCSRDKSVWVWEVQPDADFECIAVMMEHSQDVKGIAWHPHEEILASASYDSNIHLAYDDPDSDWYIFQKLHPSLPLSPPTLPALFKTSYPSSTPSSSSAPQHLIEALLPTQEEQEADAALQVPELEEDETVWCVAWSADGGWMVSGGDTGGLRVWRRTGSQSDSPFKEVLHLPAHTRSIFSLAWSPPLTTSPSDLGLIASGGGDGKIIIWQVTKLAGEEGKEVGVDVKPIAAKKNAHGVADINSVSWCVREDKKGAGLGMLSSAADDGSVRVWRVVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW62</accession>
    <name>A0A1E3JW62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033740.1">
        <property type="nucleotide sequence ID" value="XM_019173933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW62"/>
    <dbReference type="GeneID" id="30190985"/>
    <dbReference type="OrthoDB" id="3333333at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="106"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29381" checksum="48E1C89953F4238E" modified="2017-01-18" version="1">MSLVPVGAPRDAAITIGPFKPARPGYGPVLSYLQAAQLTTPLKIHPLLQLRTWDPKPYPKYLAWNAIEHPMFAAIWVDFDDTETVSLWPNVEGRFLPAASFFVNRNVRIKERGQPATSPIVEELNLGHVETGWAIRVRNRMVRPLSVNLRLKLNVLRKGITCEDVLFAIYDFFASPLYVDELGEMHPRAVRIMEQQYFEKRRMGFFDLMEGYRKSDALLGATYFDGIHNDPESVERLKNKYNFHSSNFLLLRLGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD5</accession>
    <name>A0A1E3JWD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033824.1">
        <property type="nucleotide sequence ID" value="XM_019174017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD5"/>
    <dbReference type="GeneID" id="30191070"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="258" mass="27774" checksum="24AFF51D037D5B49" modified="2017-01-18" version="1">MSLTPQALRLLSRQIVAHRNSPPEGVRLVVDEENLTNMEGWVQGPSGTPYEGGYYKIRFSFGPEFPNLPPKCTMITKIFHPNISKAGEICVDTLKKGWKKEYGVEHVLVTIKCSLLIYPNPESALDEEAGKQLLEDYEGYSKYARLMTSIHATPKLPPAEFRGATSSSERPLPSDQSVPTTTVRPTITAPSPPSSSASKPSPLGTSVSQGQSPNSNGEQKSGDEVKKVVKPAVKTAGNTVGGVKTAVASKGKRGAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWI5</accession>
    <name>A0A1E3JWI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01904</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033870.1">
        <property type="nucleotide sequence ID" value="XM_019174063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWI5"/>
    <dbReference type="GeneID" id="30191117"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="89"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO05215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33303" checksum="33688DE843833729" modified="2017-01-18" version="1">MSPVPHKQPGSSTSSDAAQRYPLPSFLESITSSSSSPLGRLPQDPIVVGIISAFGASALTFGSIIAYRRYWRRIKNADSVTMGMVERKIWVRGVVTSVGDGDNMRLFHTPGPFYRYPFKFRSIPTTQKALKNETLSIRIAGVDAPENAHFGNPAQPHAKESLEWLRSTILGKRMSCQLLSKDQYNRIVAVPYISRTFWWDQPLPILMLKEGMAVVYKAGGAEYGPWGLDEMLKIEEQARNAKKGLWAMKKYESPGDFKARMKLKDSAPEEEVKTKRRRAAPAGLWTRFKQLMSKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWM2</accession>
    <name>A0A1E3JWM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033914.1">
        <property type="nucleotide sequence ID" value="XM_019174107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWM2"/>
    <dbReference type="GeneID" id="30191164"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="171"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="38132" checksum="ABE5C3E3BB391881" modified="2017-01-18" version="1">MATNPQEGSFVTLEHFIHDTFTRIDDTGAEKPVDQPDQIGGGGTFAIIGARIFLPPSKLGLIIDHTPETLPETLKDDLKAYGEEMWEFRERKDGNPTTRAVNRYQGDKRGFEYLSKPLILTPKSLEGTAFGDPLPAVTHFISYPAPRAANILGEVEALKKSKWWDPLIVWEPEEEQIDVVTALAPHIDILGPNHNEALALYALFTGPEFTDDDLKPILTRVCRSLVHLQPRIGAIIRAGHMGCCYAAPDPQGYRPEVQWVPAYWGKEAGREGWEKKVVDPTGAGNAFMGGVAAALLEGKTLDDAVKWGTVAASFVIEQNGLPTLTKGEDGKELWNGEDPWERLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ53</accession>
    <name>A0A1E3JZ53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034230.1">
        <property type="nucleotide sequence ID" value="XM_019173525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ53"/>
    <dbReference type="GeneID" id="30190575"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12857" checksum="EDED73231EF00319" modified="2017-01-18" version="1">MPYFPFFQHLEHLFLQDHLPLTSCGLIQRNAGWHHRSETGTYYDSMPDVISYLSPIALTLKASDQEQAAKRSMSSLVEKGRAYLYELMMKQEGLFVPPRTYGAVVTALHGLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZE4</accession>
    <name>A0A1E3JZE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033927.1">
        <property type="nucleotide sequence ID" value="XM_019174120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZE4"/>
    <dbReference type="GeneID" id="30191177"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="285" mass="30817" checksum="9C6473704DE65053" modified="2017-01-18" version="1">MNAREILVVASPLSTWRMEPQHGLAAELELVSASLLPSEILHSHVSPDHTVFTVTSSDSQLSLSVSVGQGFPKKESVAVEIKGGQMGRDEAAGWIDWVQGKLEDWDEDQDYPLYEAMTTHFLPLLAPVGTTPSPPPSKPPALAPDVPTVPHHALLVSHHLLAPSKRKDLHALSSSLSLIGFSKTGHPGIMYAIGDLLDLEEWIREVKSWQWLALRVRLAPVPVPEEAGNVVQKGQETGARGGKGRGEWTEMEKVGEALEWLRKRGGEERAKVLTDIGIGAGGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZN8</accession>
    <name>A0A1E3JZN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034458.1">
        <property type="nucleotide sequence ID" value="XM_019173753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZN8"/>
    <dbReference type="GeneID" id="30190803"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="422" mass="45401" checksum="574E2E81E1B71365" modified="2017-01-18" version="1">MSSFGHSYRVHTYGESHCKSVGCIVDGVPPGLQLTEEDIQIQLSRRRPGQSDITTARSEYDTVHVQSGTEHGVTLGTPIGLLVHNKDQRPHDYAETDLYPRPSHADYTYLAKYGLKASSGGGRASARETIGRVAAGAIAEKYLKEAFGVEIVAFVASVGKTALPFVDEEDEVLGKQYMDLVNTVTREQVDKEITRCPHRETSIKMEETIRAAKARDDSLGGSVTCVIRRAPLGLGEPCFDKLEAVLAHAMLSIPSTKSFEIGSGIRGTTFPGSSHNDPFVEGIDAKTGGRRLRTETNWSGGVQGGISNGEDIYFRVGFKPPATIAQEQSTARYDGTGGVLAAKGRHDPCVVPRAVPIVETMAAIVIMDMVLQQNARMTAASLLPDLTHLPPTMVLPGKSTVKKVVEGSESLGEVQSQKPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZT5</accession>
    <name>A0A1E3JZT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034419.1">
        <property type="nucleotide sequence ID" value="XM_019173714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZT5"/>
    <dbReference type="GeneID" id="30190764"/>
    <dbReference type="OrthoDB" id="3246235at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="29299" checksum="CADDEF09465CD03A" modified="2017-01-18" version="1">MPSCRITNCTSHPLNISLKQVTALHFENGTGRAADSSFQPGKVWFTVEAVLDDETKKSRYSVLKSAATIAIISIAVGAVAATAGAALLPEVAALETVAAAGVVGSYIAKGVTATKTALVANSGTVAKISSSALPKAIDKLSGEVGGLTALQREVMSIVASPTLSSDVRHKSTALLRKLHKSYSDDKDKSAAGSSERRDPAKPSATLAPITDEEAKQLEKEVEEGKLDDKVENTPVRTGEVLRAHGIYMKERRYFEIRVAEQGKLSLYDVAEKKYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0C9</accession>
    <name>A0A1E3K0C9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034605.1">
        <property type="nucleotide sequence ID" value="XM_019173900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0C9"/>
    <dbReference type="GeneID" id="30190951"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="11873" checksum="17E00685F513844C" modified="2017-01-18" version="1">MSSRGGRGGGRGGGNQGSGERKKRESILNLAQLMDQMIKVAFMGGREVTGTLKGYDQLMNLVMDDVVEEYEGAYGRPSRSLGLVVLRGPNIVLVSPADGSAEIENPFQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2A7</accession>
    <name>A0A1E3K2A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034618.1">
        <property type="nucleotide sequence ID" value="XM_019172892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2A7"/>
    <dbReference type="GeneID" id="30189933"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="40922" checksum="9995944917C11636" modified="2017-01-18" version="1">MAHPLTQQPPSSLAFSFAARPSPLSYPFGHPPTHSPTHSPTPSRFAAAPAFSPRPPVHQSLKRPKRQRSPSTSPPTSPSSPPSKQRSGLSAAHNAASALSAPVSGLEQQSSKRTKLHASQLGQHQQGGVDVGVMLATLPLSAHLPILIQLLEANPSLASSVLDMIPQQDLKSCVKELGRRFVDIERVGGSISHPSVIPGTIAEGRRWDRVVNEVEVYCRTATTYINYLSTAVQISNDFQSLFSLLHPLTSQLVSILSIIPSSHVNNPLPGPAPLVLELAKFVLSTWSSWVTGLSSDVNDKGGMHPHSLVAHWAETLDKLVSTTTSLSPSQSSGSSHWSIPVPSQGAPCPQESELVVSFREALSQSRDQFATQVGWLIGRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2B2</accession>
    <name>A0A1E3K2B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein PMS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034662.1">
        <property type="nucleotide sequence ID" value="XM_019172936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2B2"/>
    <dbReference type="GeneID" id="30189977"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="231"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="836"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115347" checksum="44C48C954B59ACDC" modified="2017-01-18" version="1">MSGTIKAIDKASIHHIHSGQVIQNLQGAIKELVENSLDAGATSVDVKIKDNGLDTIEVWDNGSGIAEADWESIGMRHHTSKLPSLEELYKVTTFGFRGEALSALCSICSSVDIITATKELLPMAAVLKLGKDGKVVDHSGRTARTRGTTVILTGLLTPLAVRRKEFERNVKKEVAKALTLLTAYALVPASVSLKDGRTGVRLKVEMIGGGRSSKRNTQLATDGKGSLRSAVGAVWGPRALEGVNDVDLDLEVEIDKNMARREGITEKSQTVKVRGLISSAQWGQGRSSADRQFYYINGRPCNLNSVAKAVNEVYKSFNTNQLPLVILDFQIPPQSVDINVSPDKRTIFVHSEDRLIESLKAALDVFFQPARNTFTVEGATQTVKSIRHVQSQLSLGKTQAPVAAEEESQDKDNEDQSRSQTPVDEDQGESEEVTQKQASASIPSSRRASRSVVNAAPDTEADEDDSMEITMTPIATSPTLVSSSSRRAPTSSSTPSRASRVVQQTLNTSQASWSPEKKASQTTSAGKGRRLDAKETRLNLREKLTAYASQRPVVRAASEEEADEGGADDDHEEGIAGEGNVSEADDAEEQEDRIEVEDEDEVMPKESEGEPEVLTAEDQEEELPAVDVEEDEPQAIEVDSETEISQPKDTSRRRSQPVFEDESPVASTSALPSRRSSKRISPVPMPPPQQKPSSRRRRRESESESSPQLSKKMIETQASDDEADSTQPLRESPRPSSTSRPSLAKSQKSSGAYRDEIISTAPQGEVTMRFDVSRLRARINAKRQSRDTVKASRDAFTAVTQGGLANAAGIANKDAELAEEALSRVISKEDFEKMQVLGQYNKGFIIARLIGKHGKGKRTDDLFIIDQHASDEKYNFETLQQTTKIKGQALIRPRPLQLTASDEIVAMENMPILNANGFDVLVDEDKPAGRGERISLKAMPVSKDTTFDFRDLEQLLHLLSDNSRPSGQMVRCSKARAMFASRACRKSVMIGKALTKNQMSQLLRNMATIDQPWNCPHGRPTMRHLFKLDPPAKPRSGRGRIDWLSWKEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2I8</accession>
    <name>A0A1E3K2I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034742.1">
        <property type="nucleotide sequence ID" value="XM_019173016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2I8"/>
    <dbReference type="GeneID" id="30190057"/>
    <dbReference type="OrthoDB" id="2565032at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="67467" checksum="9614F1A42A24D364" modified="2017-01-18" version="1">MSRRVSYQQHRATLDSFRDPSRNRFSHGSVAESETDLESIFSSTTYQSHDSSPYPLQPLLHPPFESTSRSNFDNLARESSPFSPGRPYSSSPGPTYRKPRRASNLGPLPTVESNNNPGVSALGLEITPEGVPTESHLPVAAQQSNPKRDRRRAITAERSTLTGGTFESPLRLWIRWMTWRGWAGWTLCVSQVGAVVINLISGQLSGRFAQFKPGDWVVEALRALIWRVAVWSWARDEGQRGGRSLRSQITSILTINLSPLILPVDHILALSSTVASLRLLSSGHDLSAAAIALSTCILSAKTWPYALSVWGYLVGKSIWMGGRQQMRLSINALLVVSPLLAAYTCYVRKRIIYSIDVLLSGLLSAPGPLSSEFLIPLLEVLPLKECIAYSDGQHTWHTVLRTIQAYISRHRLLLTGNLIGALAPLAVLLYSSYPFQPPRQPSAHQKSSPRRPPMYNLILQTMFIISSSSSVFLGSRRDVVLPVLPLLLMMSLRGGSARGSERLGVGDDVWLAGSWAACVGAVTAAEDLRSLLVSLAAAVLWSTLIGAPSHLILVTSLAGIVRYGSMMVPSIALASNVVFTLAGVAGWAWGMEKMVESAWALGGLSGRRSTTKGKDTRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2J1</accession>
    <name>A0A1E3K2J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034532.1">
        <property type="nucleotide sequence ID" value="XM_019173827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2J1"/>
    <dbReference type="GeneID" id="30190877"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="47065" checksum="E5C1DDB3C3E43DF4" modified="2017-01-18" version="1">MCENWSKELWASAPWSVINKTVTPPSGDLRDYMSFAVYYWPDCSEAGNTTELADEEMWNTCKYVRRDGIFNPDIYLIQNPQALINVSNYVFLTALAYASTGNPEYSANLDHALHTFFVNEKTKMNPNLNYAQIVRGPGYSEGKHTGVLDMTVIAKIISGVNVMKALKPAEWRQETEDGFLTWVTQQITWMETSELALQELASPNNHATFAYNQLSALYAFVGNNDMAKQALEKFYNGVYLDQIWPNGDQYYESMRTRPYHYRAYNLLALITNAEIGDFVGLEPSGWERKTNSGTGLREALEFAMQQDPEATKEDNQRKQLAPSIAAAIRKFGDPDGKYADFLYTIDPYYINQPWYALNAGISDSGIKWGILETTYGPIPAQPTLPVLSKTASHAAGAKRTWAPRGSGPMAGKVAPTDLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N8</accession>
    <name>A0A1E3K2N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034753.1">
        <property type="nucleotide sequence ID" value="XM_019173027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2N8"/>
    <dbReference type="GeneID" id="30190068"/>
    <dbReference type="OrthoDB" id="3257061at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="27651" checksum="34FBCD56585A765F" modified="2017-01-18" version="1">MVLGDIPAVLAGLTWVETVCIARIRASRCCVKIKGHGSHQSKGNVVILPQAASKLSRLLPLPASVIANEIVVIWVANQAEPLTAEKIPKKLLTVRRDKIIAALQWLKENNPLYSDVSIDGDALIGYPEDGHLPMPCFNSVASASTEAEGAGYVPLPMGPSQSSDASQSSEDVMVDVSGCVDSNSSGHHVDLRKVSALAAIKGGAQFLAYPSGTTPMQEYSAPATFASLYPRLFPYGCGSFEDPLQPKKVSYVAHVAHCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3Y9</accession>
    <name>A0A1E3K3Y9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034734.1">
        <property type="nucleotide sequence ID" value="XM_019173008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3Y9"/>
    <dbReference type="GeneID" id="30190049"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="644" mass="69319" checksum="75807252BE64D8C2" modified="2017-01-18" version="1">MLATESVRPAYRPAGGSSSSSRGASGAHGSNWDEQIVPTLRNRLESESAYLTKRLSSTHFDDAAAAGIGMGNVNYESSSNHHYQPQPHPQSRPKQYPSASGAIPRSSRHPPASAETYAPAPLGSQAHQRGSPQGSPHVPSQRAGSPATTSASRIPTRPRSKSQLCSRPSLNRGGSSPVPRMPSPSGIPVAANSRSRSPQPRDPRYEGGLSRGYSSRLPDIGRERKPSGRGSPNFDGGRVTEGFIKNELPPFKMQAEDALRIAQRGHEIPEMEQWKESWHSREAEDVEEPRHGFSEDGHGGYAEPRKRAVTMKGQGGYGDSNGIGIGQTSNRGQTGTPKYRVGSSRPANISTPNNQFAGPRSASMNIHSGSSPHTPNSAQTLPSSKSRLGLAAHMIPPESSYTPPKNANWDEVVLPTVAKKMGMGDEKGSPNPGEFGEEDYAVEWDRDGMPIRWAKRKIVRKQALTEQAENMSTPNKPIFVPTFEASPDNPFRPPSTNFAQHSDSIELGALRGSQRHVEQPSPSKAEFQSQPGPTRKQSLLRKVSSQHMSHSASQRSLRTQNQAGRNDTFGGPSQWGAPQAPPPTPGTTNRITDAIYEKHLGSMERFNNAQVERNNKVGGDGSGAPPVSSKDDGKHGKGCGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3Z3</accession>
    <name>A0A1E3K3Z3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035030.1">
        <property type="nucleotide sequence ID" value="XM_019173304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3Z3"/>
    <dbReference type="GeneID" id="30190345"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="896"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116441" checksum="BDBFBB685E36813C" modified="2017-01-18" version="1">MSPFRKPSLSTLPSHLELPTTWAKFRTILMGSMNFYRIHLIAFTVIPLITSGIMYACNTEIHISYIDCLFCCMSAMTVTGLASVNLSTLSVVQQVILFVQMIIGSLTFVSIVMIMVRQYFIRQSFKHVLQERQNLRNRLSKTLTRVATVAPPLSALRKKFSRKDKDGVDSPKGPPKRSSTPSSFELNPVAPSPRKPEEHKSKKKRHEKLRPDMIKRVEGGGVGLVNNMGWYDAQREKLATPAPTPERRGSPGSPLPTGSTMLSDSGKELTQALEAAVESGAVPGHQVEDNGEAVLTESPTGMENYQRHDGERRERLRSILEAPDINVQTVSTDTTEHYSGEEDQSPSPPHSPDAFPRSKTIAFEDTMDDSHDFRERATSTQRESFFPHSATFRSNQGQSTNQDRLPYSATMQSGAGNFPRTYSLRPTNSNRRRDNRLQGFGGFPTPLDIGKKVFRKVFPETSKNLSKSFTMPRTNTYSGKNTMTATGTSDGKEVPYISFAATVGRNSRFQGLTKEQMDELGGVEYRALRVLLHIVVGYFIFVQIAAFIIMAPYIAAGGRYQHVFDDQPRQVKVYWFALFQSVSAFTNTGMSLCDLSMVPFQRAYLMIVVLIILIFAGNTAFVIFVVQCEWTLYKLVPVTSRIHESLKFLLDHPRRCFVYLFPATQTWVLALVMLGLTLIDWVSFLVLDLGTEAIMSLPVGTRIAAGFLQSAAVRASGFSIVPLGALAPAVKVLYVVMMYISVYPIALSVRATNVYEEKSLGLFDEEVEDDDVSEEGEGAQAVAKYIGWHARRQLAFDIWWLGFALWLVCIIERGHIDNDQEWFNIFNIIFELVSAYGTVGLTVGLPYDNFSFSGSFRKLSKLVIIAVMLRGRHRGLPVAIDRAVMLPKDFTAEEEAAFEEERSRRMSRSRRGSSFYQEEPFAPRSRPESFGGTGAYQEVNFTPGPVTAIPIPHHHQHHVIHSEQKAEQIGSGPGGVHKFGHFRSNSTGSNSHGPESPTFQPRESEDRWPHNGNRALTPVREGHMSSAQSYPPVYTTDSALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4T2</accession>
    <name>A0A1E3K4T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034994.1">
        <property type="nucleotide sequence ID" value="XM_019173268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4T2"/>
    <dbReference type="GeneID" id="30190309"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="237" mass="24157" checksum="6D111BF3E6E8D9F1" modified="2017-01-18" version="1">MAVKKTTTVAASKKPAAHPTFLSMIQDKSQLTHSLLQECITNNKEDVRKGVSRPAIKKYLAETFKLDMSSAANINNLNSAIKRGAEKGELILPSGTAGKVKNAPKQKKASDDKENVAPTTKKAAPAKKATTVTKSASKPAVKAAAPAGKKPAAKKASTTTKAAPKAAPKAASTTKAAPKKTVAKKAEKPAAKKTSAPKKAPAAKAAAGAKKTSAPKKAPAAKAAAAPKKAKKVATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5V4</accession>
    <name>A0A1E3K5V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine(38-40) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035173.1">
        <property type="nucleotide sequence ID" value="XM_019172231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5V4"/>
    <dbReference type="GeneID" id="30189255"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="60721" checksum="77FC141AB8FB3914" modified="2017-01-18" version="1">MAAHQNSRPSSLTSAIWLDSGYMLPTPLRLVAKRKMSKYATWSKEQLLQKLVALEDANNSPPLAAETEPTKAFVKAKKKDKPFHFPSHPTRHISLLISYTGWPYSGLALQAPPTPHPNYPPKSALPDEITTVEGELLKVLEKTRLIEEGKGWEGCEFARCGRTDRGVSGDGQVVDLWVRSNRAEGDGGGELGDGWRPAREPAPARPPVTEEEGEGKKAKKAKQTPEPKAPNEFPYPKLLNSLLPPGVRVLGWSPLPAAFSSRFSCTQRHYRYAFHRRPTPTSPPLDLELMRQGAALLKGEHDFRNFCKLDGSKQIENHSRRVLDAWFAEEEQGMGKEWVVFNLVGTAFLWHQVRHIIAILFIIGSKLEPPSLVSSLLDTEKFPGKPSYAMGHPLPLTLFECGYAEEDVDWRFGTYDGPWRGLSEEEKKGLYEGAMGGREGLERQLAVAHQEAELKAWHIAAPLRKLHSLYGPVLAEKAVKAEEKNGKGKEQKVWPVGGGEYGQTGKWVPVLERTQGATPEEVNEKYRETKGKARAERKAVEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K631</accession>
    <name>A0A1E3K631_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleolar essential protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035456.1">
        <property type="nucleotide sequence ID" value="XM_019172514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K631"/>
    <dbReference type="GeneID" id="30189545"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="332" mass="35913" checksum="6524E3F5044A5B9F" modified="2017-01-18" version="1">MSDTPPKRRAAEAASSVPPAKTSAMSATAPPFNPTRPLSGKSKASFHNIAQEMKPRVQTGSEENAMEVDGDREDSAPRVTKPLPAGKRSVPRADFVPQQASVPKSNEDKENTRRLIVVLSQACLEAYKISSGSGGKNASGKEAKYALLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKAGLLQVYIHTAKGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRGVNGSEKLLRVIKNPITDHLPTNTIKLTLSADAPTIRLSKFLPTLPETHSVCVFVGAMARGDDNFGDQFVDQKISISDYSLSASVACGKFCCAMEEIWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6I6</accession>
    <name>A0A1E3K6I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035402.1">
        <property type="nucleotide sequence ID" value="XM_019172460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6I6"/>
    <dbReference type="GeneID" id="30189490"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF58">
        <property type="entry name" value="LOW AFFINITY HEME TRANSPORTER STR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="67797" checksum="CFCE9932063D7442" modified="2017-01-18" version="1">MSHPTQLDSHEDKKALEPETVPSLHRDDASSAEAAQEKSVGVSKVETFNKVLYQSGRSGKFLLWSLAVSIGLTMFVYAFDQGITTTIFSPWATSSFGEHANLAAVSTASQIIRAISKPFIGKLADITSRPTTYAVVLVFYVVGFVVAASAQTFAAYTVGMAFTAAGKSGLDLLSDIIVGDLTVLEWRGFFGAVLSVPFLVTVPINGFITEGLQDNWRWGMGMFAIMVPVLLLPAIATLYVMQFRGKKLGMVTMAGSNNERTGVDGQSRTWRQSLKQGLIEIDLFGLVLLGFGFSMLLLPFTLRKAAVGGWKNPSMIAMLVTGPVILGLFLLWEMRFAPKPLMTRKILFNRAVIASIIIGSLSQLASAVRNTYFYSYISVITPWSTYTQTIFVGITTTGLCLVGPIVGLIQRRTYRYKSLMVFGNSCRIIAYGILVVGGSNEMTRSTARLTVAQLMFFGSQASVPHEDMASVIAIISLWSTLGSSIGGAIAAAIWTDMMPDELARQLPDVPAATRTKLYGSITAITKYSFDDPVRQGCIRAYAVVNGHIAIAALCLATIPLIATFYMPNFYLGKQQNAVNGTGLDGEKVVVDDGNRTEAEAFPAGEESAPKGQQKLIQRLRVLYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6P6</accession>
    <name>A0A1E3K6P6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035596.1">
        <property type="nucleotide sequence ID" value="XM_019172654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6P6"/>
    <dbReference type="GeneID" id="30189687"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="671" mass="73247" checksum="DD27BBDEE4CB39DE" modified="2017-01-18" version="1">MSSFLSPLTDFYFRWRINTQVLARLLHNQTPLFRPTRVHLVSPQDQAVPQHLLVADMTESATKTARGIGPGTIALPMEVTGPCQEVEDASTGPHPHVQGVNSAPIANNRWGNNNAGAVAADGDANLGNRRTDPEQEAESASQPVPVLTTTLNALKPDLIPAASAAAASLLPTSGAPASGVETTEAKRARLREEARNAKLLLDRIAHEEANLEQEERRAQEERRREQEAQKLRKIEEDRRRQEQERRREEELRLRQERELEERHRPEYERDVRERERSALFPPPGLRDARPDFRGERPDRGFLPPQDFAFAREPLPPQGALSRDGRREGWDRRRASDGFGHGPGPAGDYPPPPLGERERVPMRDRLGGGPRDRVPFDQQQAPGPFGRRPLSPPPGHPSYDRRRSPPPGIYGPRGPPGPVRGGPLDHPMPPHMRGDVRDRDMRDMRDRNFRGRDIGDRDVRGGREPFFPPGPPGRGPESRGEPGFAGPPPRDLLRRLGKRVDHQLAEPMGGNLQRDDRRDVTPRRGPQQNNNAQTPQSRPLAERMSAVSSPSTPPLPPTAPASDPSLPVGSNEVLSAGDVIDEQQGKGQGGGQGQGQGQGHGQGQGQGQDKQERRRGGRKKRGGQGGRRDRGGGGGGGRNNGNGQGGASGGGGGGGEASEEKRGEDTVDPEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8C0</accession>
    <name>A0A1E3K8C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035622.1">
        <property type="nucleotide sequence ID" value="XM_019172680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8C0"/>
    <dbReference type="GeneID" id="30189713"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="283" mass="29813" checksum="C20CED01F9C74AA9" modified="2017-01-18" version="1">MSYLQSLFGLQGKTALITGATRGIGARMALALAQAGADVILIQRDTSNTTTRDAIRATGVKADIVVCDLADSAAVSKLIPHVTKELGRTLDIVVNCGGIQRRHPVENFPDDEFNEVLQVNMNTVFTITRDAGRHMLESRGGVAGEPVPEGGVAANPRGMGKIINISSLVAYQGGLNVVAYSAAKHGVAGMVKSFSNGWASKGISVNAIAPGYISTDMNEALIADPVRSRQILERIPAGRWGTPQDFEGAIVFLASKASDYVSGECIVVDGGWMGRESFPVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8S4</accession>
    <name>A0A1E3K8S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035782.1">
        <property type="nucleotide sequence ID" value="XM_019172840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8S4"/>
    <dbReference type="GeneID" id="30189879"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="59703" checksum="DB2A1A33C6DCC601" modified="2017-01-18" version="1">MSAQQFYQGGNDKQGQPQQQYAPPSGGPPQDYNNQQQYAPPQGQPNYNMKGSQPYAQTNPETGGQPNYQNGDTAPFSQAEEKTGQRLNPRKRLNDPIFLVLFLAAIAGFAVVSGIAINSFIEVNGLGGGLGSSSSGQTGSSTTLDYHTVYILLVVTGLGLFIAAVYLFMLRTFTKIILEVTLALTVLLNIGICICKCLQCYWSGAIIFLVIALLSIFFYWGMRKRIPLAKLLLQTTIDVTKHHPSVYLVVFIGLLVQAAISVWYTFTCIAIYVKWTPGSEACSTDCSSSKVAGLIFYSTFAYLWMSQVLGNVILATLTGGVFGGWYYYGPRNQWGGVPKQASLKAFVRATTLSLGSIAFGSLLVTLLELLRLILQIFQQYESGQGDMIGAALICVAQCCVGCIEWLIAYFNKCESLYGKAYIPAAKDTWRLLKDRGIDALVNDSLVGTALMWGAYINGFLCGVLGYLYLKFTNPSYNSDGQYSAPVILFSFLIGLTESNAISAAIDAGVSTIFVGLGEDPMVLAERSPGLFEMIRQAYPRVLQGVPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HIR5</accession>
    <name>A0A1E3HIR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein light chain roadblock-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027886.1">
        <property type="nucleotide sequence ID" value="XM_019180117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HIR5"/>
    <dbReference type="GeneID" id="30197357"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN75616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13009" checksum="B7578673E83348D8" modified="2017-01-18" version="1">MEAPPEVEATLSRLSQYRNVRGVMVLARAHIVGDTPHPHPHPSRSGDAGIVQTTGTVFEGEGGAKYAGAVERIVLSTGAAIAECEEGDELRLMRIRTKRHELIITPDDKYVLVVLQDPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP04</accession>
    <name>A0A1E3HP04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07997</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028031.1">
        <property type="nucleotide sequence ID" value="XM_019179970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP04"/>
    <dbReference type="GeneID" id="30197208"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129261" description="Endonuclease" evidence="11">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="79"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="80"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN78078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="39503" checksum="C38EBD67FAB2F77C" modified="2017-01-18" version="1">MPTIGPSLLFAAGLTLGVGAGVLYPKQSQAAVPLPPAPPEGALRGVSEAKESRALIPTAGGIVGPLQHGFPGPTPDILKRVAYTAAYDRRLRHPAWTAEHITATSLAKKPPPQASTNPVPLDVARAADVAPPVKVDRSKSVFKEDEGIPEMFRAKLGDYFRSGYDRGHMVPAADAKISQQAMDETFYLSNIAPQVGDGFNRHYWAYTEDFCRRLTSNFEDVYVFTIPLYLPEKQNDGKWRVSYEVIGNPPSVSVPTHFAKVILASRPDFAYPQKPAPNSLVPATSPSTVKELALGAFVLPNKEIPDGADLRSFIVPVESVEKAAGLRLFGEEVKAKTKQLCAVTQCQVIVRRFDDAKKQFGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP37</accession>
    <name>A0A1E3HP37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028047.1">
        <property type="nucleotide sequence ID" value="XM_019179986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP37"/>
    <dbReference type="GeneID" id="30197224"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="25158" checksum="BB9FEA9D056F7962" modified="2017-01-18" version="1">MSAPISIANDTHHSPSSSASLSPQTPFFPTPALSSSATPNQPGSLFKWASSFGKSPPPAQFASGSFTSREGIGKEMGTGIPEHDGEHSDNFEFGDFNDTGNSGSWVKGRRAMSMSMPYGAQSGVGAMLKNNGYSPNEQKETPFDADKDSKGQGVLRRLSIGGPPTQNTHLPPTELPASSSLPPPPASTPSGAEGPSEIKRSAALGGNAHARGRRFSESQGNRKKGVSPMGERILREHGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP43</accession>
    <name>A0A1E3HP43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028045.1">
        <property type="nucleotide sequence ID" value="XM_019179984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP43"/>
    <dbReference type="GeneID" id="30197222"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN78092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="87" mass="10003" checksum="985B6F75532D2371" modified="2017-01-18" version="1">MHALLGSPEKQLVCAEFIKALEDCHAQGLLAKVTGQCNKPKMILNDCLREERIERTTRNRDEAKERNARKKAVWEALEREKAEEKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRN1</accession>
    <name>A0A1E3HRN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028054.1">
        <property type="nucleotide sequence ID" value="XM_019179993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRN1"/>
    <dbReference type="GeneID" id="30197231"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14833" checksum="FE78D23297CDB36C" modified="2017-01-18" version="1">MSAHGVMHFEGRPLSPQHRLHSESDLPAPGANWVDVKDVALAHVRALTVSEAGGNRFIVGAGPFAGQDYVDVLHKRFPDLPNIPVGKPGTHDEIVKDSNVFNGAKATKVLGVEYKTFEDTVVEMAESLQKRFADKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRV9</accession>
    <name>A0A1E3HRV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028100.1">
        <property type="nucleotide sequence ID" value="XM_019179924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRV9"/>
    <dbReference type="GeneID" id="30197160"/>
    <dbReference type="OrthoDB" id="10369775at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="32989" checksum="DB7F08FE9D59DB72" modified="2017-01-18" version="1">MTFDDKDHKNNVEEGGDTYSDDYEEFYSSSAQLLVDTLNQEIRSSPAYTETNTADSQAQSPSSLTFLYVKVIGKWSTSTGADGRRPGTLHPAHRHTVAEALSEMTEDTNSAVASLLPNSTPEETATLVQRTLSRMVEMMGFDGDVYVTPTPGGTQENSRLTTMQRESANNLGTVGSWVKGLSVQRIQQVGTRRRRQRTLGVSKGMDSKSYKSPSSSSILSLGTNKNQNQPTMSSNTRDQESTYSQMPTNASIRQEIMDEDPSLYTAQEADAVRHAFGGNGSSVPEQTVVEEQTATQASSDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV18</accession>
    <name>A0A1E3HV18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase A complex catalytic subunit Ard1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028188.1">
        <property type="nucleotide sequence ID" value="XM_019179821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV18"/>
    <dbReference type="GeneID" id="30197051"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="143" mass="16218" checksum="736DA5189A9B8D00" modified="2017-01-18" version="1">MDIRQATIDDLLDLYHALTWPELSYVAVDPKGRIVGYILAKMEEEPSEEPSGHVTSISVLRPYRRLGLANKLMKQSQEAMVAHYNAHHITLHVRKSNRAAISLYRDSLGFEVQGMEKGYYADGEDAYGMRCLFKKEEDTSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY85</accession>
    <name>A0A1E3HY85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028243.1">
        <property type="nucleotide sequence ID" value="XM_019179762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY85"/>
    <dbReference type="GeneID" id="30196987"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129442" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12434" checksum="19A2060F9FFFF63F" modified="2017-01-18" version="1">MSTHWAIVSMHASLLSLTLLQGNHLLPAVPQAIAGRSLHGAELLIPRCLTSAALTLADYWQGNSCTYQGNVFSWSHWMAMLKRQRQGREGSRSVKSPVLQNSTTRSYEGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY97</accession>
    <name>A0A1E3HY97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028261.1">
        <property type="nucleotide sequence ID" value="XM_019179780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY97"/>
    <dbReference type="GeneID" id="30197007"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129434" description="Checkpoint protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="301" mass="33187" checksum="A70D6D939389F271" modified="2017-01-18" version="1">MRFRTAIANVSLLTKIIRALSALAKTCVIQLSQEQLRFIVPGHESATGVQVWSQVKTGTLFEGYRIESNMNNEIWVEVNLDALHRVLKSADTAVGDGKSEAFLSDAEVTLKLGKNNSQPIWSFGVRGYTATRKQMCITHEINVKILSARRQQELEEPLCPQPDIHVILPNLLDLRNVVARMGHLGDDMEVSANHEGKLELSVKGGAVNLATTWKELRLPSVNGESSFSEVTPPPAPPDSQMFSTTVTVKGLLRFLTSHCISQDAIMCICENHCVITYVYIGPIEDAEGVLTFYIPGKDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1V9</accession>
    <name>A0A1E3I1V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028300.1">
        <property type="nucleotide sequence ID" value="XM_019179753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1V9"/>
    <dbReference type="GeneID" id="30196976"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="22452" checksum="819B1D9E748F1A81" modified="2017-01-18" version="1">MLSLTAGGLVDNTFMDFVADYHQQSLEAMKGKAGKIRKTENIGNSRKTRKGGNVLGEIIHQCDKPESLNTSVAAFYEWASGKKTEDDLPAPLGNWFDVKDVALAHVRALTAPEAGGSRFIVGAGSLAGQDFVDGIHKNFPAVKNVPVGTPGKHDEICKDLDIFDGSKAEKVLGIKYTTLNDSIIQMFESLRKRFGTTTVPSNRNIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5W6</accession>
    <name>A0A1E3I5W6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07661</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028337.1">
        <property type="nucleotide sequence ID" value="XM_019179649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5W6"/>
    <dbReference type="GeneID" id="30196872"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="237"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="542"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="730"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1196" mass="132810" checksum="77B5F0BB2FA036DC" modified="2017-01-18" version="1">MSADKEIYKLELLSLVAKVSQELYNHTKLQDKKLAEFVISLHEQSKTPDAFSKKLVEIGADFPEWFVKNLDRLIVTLHPKYKRKAAKAKAAAQSGQKSSKSTTIMDEQKQLQARKYPGLAMPDREAEKFVDDTPDTNVSSKTLPDSVGVDDTLAQLSSLSSRRARPSADDYMEGEPSAKRSRGDTTGRDNGYGGYGRNHGDGRDNGYGSRSGGYSGTSYGDRGRSGRSALDQKPLLYKIYDGTVTNIKDFGAFVTLDGVQRNTDGMVHVSSITSGRVNNPAEFLKRNQRVKVKVMSVSPKVGLSMKDVDQMTGADLSPHLMVMTAEEAAQEQRDLQARAAASGSNSMPLLGVPDLKVSRAKRLSSPERFEIKQLIASGAVSAADYPDLDDDFNTESNNPEIEEDIDVEVNEVEPAFLAGQTKVTLELSPVKIIKAPDGMLNRAALAGGTLAKERRDLKRLEANEEADAESRDVNQPWLDPMANQNERQFATDIKGSLMGQKATQTPAWKAANKVVSYGKITSMSIQEQRKSLPIYKLRDQLVSAIRDNQILVVVGDTGSGKTTQMAQYLAEEGFLERGKLGCTQPRKVAAVSVAKRVSEEVGCRLGAEVGYTIRFEDMTSPETKIKYMTDGMLLRELLVDPDCSKYSVLMLDEAHERTIATDVLFGLLKKACKRRPDLKLICTSATLDAAKFAEYFWGCPIFTIPGRTYPVETLYTKEPEPDYLEASLITILQIHLMEPAGDVLLFLTGQEEIDTACEVLYERVKALGPQVPELIILPVYAALPSEMQSRIFEPAPPGARKIVIATNIAETSITIDGIYYVIDPGFAKQNAYDPKLGMDSLIVTPISQAQARQRAGRAGRTGPGKCYRLYTEIAYRNEMLPNPIPEIQRTNLASTILTLKAMGINDLINFDFMDPPPAATMLTALEQLYALGALDDEGLLTRIGRKMADFPLDPPLSKMLIMSVDYGCSEEALTIVAMLQAGGQVYYRPKDKQSQADAKKAKFHQPEGDLLTLLAVYNGWRDSKFSNPWCFENFIQTRAMKTAQDVRKQLIGIMDRYKHDLVSCRSNFNQVRMAICSGFFRNAAKKDPTEGYKTLVEGTPVSIHPSSALFQRPPEWCVYYELVLTAKEYMHQVTVIEPKWLSEVAPTFFRIADQNKISKRKALEKIEPLFDRFAADKDDWRLSKQKKLGRSSQTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA13</accession>
    <name>A0A1E3IA13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028417.1">
        <property type="nucleotide sequence ID" value="XM_019179560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA13"/>
    <dbReference type="GeneID" id="30196779"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="194" mass="21093" checksum="2EFEF94A081267BE" modified="2017-01-18" version="1" fragment="single">NPTRRPALPTPPPTHNHLEEASQAEEPDPASFPQRDLPPSPTDKPHGSIFDLHFLRWSIFVDGVLTALTAFSTNSWHLYLAAGVLPFASATGSACKGVVMDLLVDTDQRADALSAIALVEKLGMYIPFFRLHSNEDIANVNSAQVSTISVFGFVFAALSERGQPALVFFINGCTAMVAFMFTLFVRMSPTGKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA51</accession>
    <name>A0A1E3IA51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Two-component system sensor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028483.1">
        <property type="nucleotide sequence ID" value="XM_019179537.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196754"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17574">
        <property type="entry name" value="REC_OmpR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000307">
        <property type="entry name" value="Receptor-like histidine kinase BpdS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000045">
        <property type="entry name" value="Two-component system sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000230">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.240, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="736"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1322"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1631"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1097"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1793" mass="200849" checksum="CAB5B88A517F6563" modified="2017-01-18" version="1">MYHDTINYSTLPKEYLQSYPYPAFVLLVPIPPPQPSRTDSQDEFSTPRSTHDPSSQFTRSDHGEIQPFEIVWGNKKWTHLSEGLPLLDCLDVDGVRRLGDWISGALTPTLSPTQKTFPSLDNPVPGSPPSPENFWSAEHPYEDRSPRSDGLASDHADLTGIEPFEKSNPGLATLEINLINPGRITLELTKTLVPVPRTRKGFENVPMRTHSFAVITSTPRTAFVPNTPQQVSHHGVPPVAYRAMLDKDRSPIKSKEVPSETVHPYLIPKTTILSPSPSVPTSLDPSIPRRSTTPHPKDDSFSSFGELRGLGLLSPAQNGKTSKPLMFNVDGTISRQADTSDKKEHASVDDLMASTDWTKTPLGPREQWPQSLKTIVALVMNYPHQCCLWWGKDLTLIYNEPYAKAIHKHPSIFGMSGPSAWSEIWSSLGPISEIVLAGTPVWKEDDFLLFRQLAHQGDGVFEEYHTWMWVPILQEDGTFGGLWNATIRTTKKVLAERRMATVREMGQRTAIARTMEEFDKAVVDILENNPRDAPFAALYHVDQIAPVTKHDPNEIHVNVPLVGSVGIPDNHPSTPSNVSFPLRHRRRSSTTRFSQGDISSSSALSMHSSSSEGHPAPETKSWPLREALQCRRLVLVEDVTELIKDFNVRVWDELPSAAVVVPISSDSDEEVPNAVLVLGLNIRRPFDEDYESWIVSAFLRLQLASGIAAVHSYEVEHQRLNELAAIDRAKSLLFSNVSHELRTPLTLIAGPIDDLLLETTDNGHKDMLLMVRRNMRRLARLVSTLMDVSRLEAGRLRGTFRPVNIGTMTSDLAVLFKRAIEKAKLQYTIEIDNTPENAFVDPEHWEKIVFNLIGNAMKYTMSGFVRVKLHYVENQIVFEVKDSGVGIPRSDIHLIGERFHRVQSVSRSHEGTGIGLSLVKELINLHGGSFEIESVTEEESEDRSHGSTFRVRIPLGCDHLPYEAIDHGSMPNLPQSTYGEGLVDEAMQWVRDNRDGLSAISSDESSNATGESGGGTQIGSGGTGVSGMTSAVPVKALDPNTLYFAKSDIIMLVEDSSDTRRYMKSIFAQYCTVVEARDGREALELCAKQRPNLIISDVMMPHVDGFELLTTLKNSSEFRMIPVIMLTARGADESKVSGIMAGADDYLAKPFNAREIVARAHMQLQLGKKRKHLEEAFEERTAELRVLSEFSPVGIFRADEDGKLTFVNSTWYSLSEFPTNKTLEDWQDIVPDQERDDLNEFWSGFLTSGERTRTRDWRYKNGKWSEYLECNHGSMLTIAIVTTDITERKIHEQSQHQQVVEAEQRRLEAEEAKRQQELLIDITSHELRNPISSMMQMSLFTFLYTNLLSLQEQLHLAIAQQKPFNPTRQLMNNIDEDLEALESIYQCGLTQERISNDVLSLGRIQLDMLEVFDVEFDLWKEAQNILSIFQNEARMKRIALSFKAGESHKKLGLTWVKADLVRLNQITTNLLSNAIRFTANSAVRQVELRSEISFDPPEDGACTMPREPTLPKDIKDDMTMYLYLEVADTGPGLTENEVQKLFQRFSQVSPKTHTVFGGSGLGLFVCRNADSVSVGGGITVVSEKGKGSTFRWYIKAKTCHTVPQTAANSLRAKLKASRDAPRYFGLTRNPHVLIVEDNLINQTVLARQLNHCNLTCDVASNGLEALEKIRKASSVTPIEGQEPVQCFDCVLMDLEMPVMDGLTAAYVIREEEAAGLMKKNLIIALTGNARQGQIDEARARGMDDIIIKPYRLDDLLRKIEDMMKIRADDEDAQMALDLKNVEELEAADKTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBA8</accession>
    <name>A0A1E3IBA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028608.1">
        <property type="nucleotide sequence ID" value="XM_019179467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBA8"/>
    <dbReference type="GeneID" id="30196683"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="112" mass="12715" checksum="CA6D539C7939C400" modified="2017-01-18" version="1">MGQGSGHLQDRVQWPINTRQSYLWMAKHGVSTRDDVMSLTFFCKKYKALRVAAGTDFAAEWAPKVAAWITKYNQHCRPWLTDPPSFSSSAVYSKASGFAHKNYPLECNLLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBK9</accession>
    <name>A0A1E3IBK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028563.1">
        <property type="nucleotide sequence ID" value="XM_019179422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBK9"/>
    <dbReference type="GeneID" id="30196633"/>
    <dbReference type="OrthoDB" id="10370890at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="551" mass="61552" checksum="3C1CF172084D8235" modified="2017-01-18" version="1">MPESVSRPATGSQYQLLPSAPAERSQITLQYEVVKYYPISQLLSTSTPHPSFPMTHHHKTTINQIIDALSAHTAEDSVSFVLPTLSHIQRKDILEMEDIRSIHSVLGRLDDSLRYFENEEGGDQDKVDLFDMVQGLSRDLLGGVPNPRLTSMVYIYYNVTPHQTTPTGLGASIANDGPLPDIHQAIQSHIITIQSIISSFKGHDLSTSPEAPTTSPPISIPMTYNFRFNCQQIISRFSDHSDAAGARYDVPIFDSIQQKDVLSLEDVGELHGVLSRLRSEFCDYSAMPDEETKTKAMIWGRTMQDLEAPLNKGHTFSLKVSLKTLNSLATLLSHPTLLPILQAAAARRSHLFPKANFETGLDNEPSWSDHGWETGKRRIRDDLLPNVLTALHTNMKVIQAILSSSQKYDLALYSKTSSTPPQIPMTYDFQNTLQYIISLFAAHSDAASIKFAIPILKAVQTKDMLDMEDVGQLHQALGRLESEYEAFHVADWWPKDAFIDDFHFNDGEGPDEVLSRLMERLAQDNLGHLITLHLPPSGCTVAEELSRLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDP2</accession>
    <name>A0A1E3IDP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16933"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="EC" id="3.5.99.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028576.1">
        <property type="nucleotide sequence ID" value="XM_019179435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDP2"/>
    <dbReference type="GeneID" id="30196646"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008660">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009310">
        <property type="term" value="P:amine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06449">
        <property type="entry name" value="ACCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005965">
        <property type="entry name" value="ACP_carboxylate_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01274">
        <property type="entry name" value="ACC_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="8">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="37426" checksum="56A02D7A43DE6379" modified="2017-01-18" version="1">MTEAYIKKLTSIPKENFLFGPSPISPLPNLSSHLSPSNTIRIFAKREDCNSGLAYGGNKVRKLEYLVAAAKAEGCDTLVSVGGVQSNHTRAVTAVAKSSGMGSVTVQEKWVPIDPPLYASTGNILLSRLMGGDVRLNQETFDIGHKKATEDAFKEVQDKGGKPYYIPAGASDHPLGGLGFTALLLELLPQEAALGIFFDTIIVCSVTGSSHAGLVVGNILDGRRRKVIGIDASGKPEATKKQVEKIARDTLEMLGEGVGEGEKEEVREEDVILDDRFHAGIYGIPDDETIAAMRLGASKDAFITDPVYEGKSLAGMIKLIQEGSIKEGSNVLYVHLGGQPALNAYSSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IES5</accession>
    <name>A0A1E3IES5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028906.1">
        <property type="nucleotide sequence ID" value="XM_019179148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IES5"/>
    <dbReference type="GeneID" id="30196345"/>
    <dbReference type="OrthoDB" id="2576433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="234" mass="26185" checksum="458E057B72A2FF0B" modified="2017-01-18" version="1">MGPLISLLYMIGATVGCIYLKIWSEAAICAASAVFIVLCVFIFKSRYRLARDLLDTANQAAQAHWSVFWTVLIGTLVQGLSSLWNIATFISVFLVFEPWHQGCDDGDYCSAGMTWVLLIFVIIEYMWISGVISNVTLTVMAGGPYALVDGSLKVDEWWNWLILLYSFILALNIGLALTSALEAGVTTIFVCLDKDPDYLKQRNPRFYDDLCAHPSYYSIVMPEANQPLQPREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFR3</accession>
    <name>A0A1E3IFR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028928.1">
        <property type="nucleotide sequence ID" value="XM_019179010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFR3"/>
    <dbReference type="GeneID" id="30196203"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1052" mass="111217" checksum="6E243D2F0FEDE9B1" modified="2017-01-18" version="1">MGSSQSQPSRTSPPHLPAPPRRRPNNPLSSIRRLSTLGRRGASPVASTSTSHGEPMQVERTTSSGGGKRSRQGSTAEGHTNETERKKARVGEAEAGSSEDVSMADANEYSTPQPAEPYSQPGLAPPLSTAGGAPMSPTGSHDSLTEERMSTIDTIRSTLGPDWPLPDTPSAAEVERLTRRQLANRTEQPSSFSSGPSHPPPTGSSSSGGESVLRTHDSTDPHVAEARASLQRATAQAQLLADRIATLSQQFNRIPSPSSSRPSSSSSRPSSLSQAPTPDQGPAPAPAVGSSREGMMRHLHRRLNDAQSQLRDTERQLDATRERLDTGGARRRRVPTGAVLVIQGLAQTQGVGEDAPGSGNEDVEDDFLRDTAMDEDTPEQARPRERRASEGDSRRPSGSREERQDASLESQARMIGGLLTVAAAATATTLLAPGGNRPSLASALAPPRPSPSSTLESLLNRIRPNRQEAAERQEVEERERERAQSQEASLGTYLRNVLRDNRVGSISSSSSPSTTATSPNPPTQASEPTSTSESTASTHESAEEAEEAISSGFQRFLEDLQVDLAVAVREFAGPLPAAPNVEASEGTGPQDTAEASMDIDQEPVHDTSSTPPNPTSPPPPPSSEPPIPSFHPQLAQNQPPTSSSSSSSTRPTAPTVPTAPQAVTGGYDGVPRRMNFFRAHMFPAIDAYTARAVEGPLRGGAGAQPSGQGEQSPSSAASPNNPQNASSEGQAESLSNANAQEPAQPQPEPLIPTIFIGVRNIRHDASMSTEDLVSHPNFPFVNGEVPARDVSAEAGSILREGEGGSVGEETVHAAEEEGEEDGSVGGRDEGRRTRASSAPPARQSLRERIFSHLRRPHIIPVSSSASPNTSHSTSNTPATINTYLIYIIGANYPPAHPILRMPSLVHGGEMSDEELRLVGEILGPVKAPTVAKGDIEKSGLRVVKGGDMKKEAEEGRVLESCAERCLVCLSDYEPEEDCRILACRHAFHQDCVDHWLTQGRNSCPACRAEAVETKPSWSAQEATAPQAPEVPLAAAAGTSASTTTTSTLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFR6</accession>
    <name>A0A1E3IFR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028997.1">
        <property type="nucleotide sequence ID" value="XM_019179079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFR6"/>
    <dbReference type="GeneID" id="30196275"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="950" mass="104257" checksum="44BEB38B2D1B9391" modified="2017-01-18" version="1">MAASRMALARALIEYDNDSDDEDTRKDWRQSAIFIPYHIAQQEARRQQILSQPAPVLPSPLEATFPGDKTPTAPAHRAPLPLPAPQQVGDGEDIADVRDWGIPSHLVSAKAGLPPRQRVVSRPVPHPVPPHTRAQSQHASEHFHDDPQRTTHGDRRVSLDQYSSTGQNLERRERSRTLVGRPHSAMGLQNTMRPEVRDRRISNPVMIPLPSSPSPTTTLLPLPSLSLGFDTGLGDEEEVIDDGRPNPFAVAAPRPEMGSRFDPKVLQEQRRSIDSTRSIVAPRPPSLALTLDGNQPQSSDYPRQSSDLSSRRSTDLPHLSRPSLDSYHSSPILDFPRGEEYDEIPTPQAFGRSLMPLRYAPSAVKRMNRNSLRPTILVMPSPLADAPSAGYEQKTRDGFVLGEKPLPADAKTQGRRPGIPLSLSQRTFRSSLMIDGRREDPEWIGGAEKDGEIGVERRDTSEAFLEKKAGKLYGQSLMDELEARKSNMKGRSRTFMGDSRPAMMSRSSMHIDSASLSPTSPLSATSKRPGSFHPGGRQPLLRINSNEEDIYALEAPGMNSRENKSQSVFGVDHIWEREMVKLRQLQEQEARLQKANQEERRRKEEEEEGKKKKRKSRAKSKLSEEWSREDWEKVDDPAKQEPIVESLQETASFRESIKERDDNYYIAEGSVAGSPTPEEPVVEEDSDSDDSEANVPLSKLANKSASLRSPSVQNASGSASIIQSSASALVVEDDDSDEDVPLSRLARKSPSVSSSSQPRPPTTSEPLRLSLGSPTPSKSYSEEYGAEEDDLPLAIRQAQSKGLKPPTRAEVVEDDLPLGYKHADVVQRQMQKRNVNGVSAMSGMSGQGSMFGAPQMGMGSPYNSVWGMPQMPMGQMPMGMPYGQPMGYGMGIGMPSMGMMGQMGQMSVPNLAGPGMMAGDGNEGPAANIDSWRHEVPLGVGSARSGEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGR3</accession>
    <name>A0A1E3IGR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028900.1">
        <property type="nucleotide sequence ID" value="XM_019179142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGR3"/>
    <dbReference type="GeneID" id="30196339"/>
    <dbReference type="OrthoDB" id="10290137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="13000" checksum="0E033AE247289E8D" modified="2017-01-18" version="1">MSQQQPTENQSQQSRPAISFKEDIFANSQTTKSPENASTRPTLLSIPPRQAMPRRPSRVSGSDTKTVTISKATADSIKFHPELTEDPQSWESTAEGYVYTGTKDIDPNRPWHQPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHG2</accession>
    <name>A0A1E3IHG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029105.1">
        <property type="nucleotide sequence ID" value="XM_019178828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHG2"/>
    <dbReference type="GeneID" id="30195987"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="34605" checksum="9FD3DA17EF0889AF" modified="2017-01-18" version="1">MSSSEPTIIPSSNPNPNGAPASHGTSTPLLGPRGGGASSGAGGSFGVKSGLAQMLKGGVIMDVMNAEQAKIAEEAGASAVMALERIPANIRQDGGVARMSDPGMIKEIMEAVSIPVMAKVRIGHTVEAQILQAVGVDYIDESEVLTPADDQHHIGKHAFKVPFVCGCKNLGEALRRISEGAAMIRTKGEAGTGDVVEAVRHQRQVMGEVRKAAAMTDEELYAYAKDISAPYHLLKETARLKRLPVVSFAAGGVATPADAALMMQLGCDGVFVGSGIFLSGDPAKRARAIVQAVTHYNNPTVLAEISTNIGDAMVGISTAQEGANIQGGRLAGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IID3</accession>
    <name>A0A1E3IID3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029029.1">
        <property type="nucleotide sequence ID" value="XM_019178935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IID3"/>
    <dbReference type="GeneID" id="30196121"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN87686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66912" checksum="AD75E503AC070085" modified="2017-01-18" version="1">MGALDVLPAHLPTVLRDSPPLYKASATLIVFVLATYLWLFPIANARIPFRNLPDPGPGHWLLGHVMNVFLAPTPNATNITFHKAHGPTIKYRTQLGRFEVSTIDPTAIAYILNHPDIFVKPPALRDWLYLRIGNGLVTAEGEHHKKQRKAMIPSFSPAAIRELAPVMLDVANELKDKLDGLIAHKDEYTLSPSPAKPIDAVPGGAKVNILRYINMSTFDVIGLTGFGHSFGSLSDRKNDLTASMQRFLQNMFVARLVDYLFGQYQFQLPTEKNRVVNKEKQEILEFARRIAAERKKEILEQSYGEGINKKQDIGKDLLSLLSESFGRLLCILNELTGWTVKANMASDMKPNERLTDEDVADQILTFLVAGSETTATSLALYLDIISQHIDVQDRLRKELLSVNEERPPFETLDNLPYLEAVIRECLRFFPAASFIYRHATEEATVPLGTPVIGKNGKLMTEFKMDTVNLLFIPVRAVNTSPTLWGPDAESFNPCRFLDDDRTPGTCKSSTKVPGVYGNLMTFIGGPRNCIGYKFALQQMKILLFVLLRNFEFRPLKSGPEMVYKPSAVVQAFVKGEEHLGVQIPLMVIPLAGAGHDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIJ0</accession>
    <name>A0A1E3IIJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029221.1">
        <property type="nucleotide sequence ID" value="XM_019178738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIJ0"/>
    <dbReference type="GeneID" id="30195895"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="38241" checksum="A1A380D0DA6C9F24" modified="2017-01-18" version="1">MSSAQTITKGDLVLVTGASGFIASHAVKEFLQQGFRVRGTVRSEEKGQYLTKLFEGLGEFTYVIVKDVNQDGAFDEAVKGVNAVAHLASPFYVFNIKDPQELIGPAVKGTTGVLESLQKYNPDVKRVVITSSVASILSMDSVKSPTRDYTEKDWNVDSAAHVEKNGLQSSGFHSYLASKTLAEQALWKFIEEKKPSWDAVAINPPFVLGEIIHQCDKPESLNTSVAAFYEWAFGKKTEDDLPAPMGNWVDVKDVALAHVRALTVPEAGGNRFIVGAGALAAQDFVDGIHKNFPDVKNVPVGTPGKHDEICKVLDIFDGSKAEKVLGIKYTTLNDTIIQMFESLRKRFSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIP4</accession>
    <name>A0A1E3IIP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029279.1">
        <property type="nucleotide sequence ID" value="XM_019178796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIP4"/>
    <dbReference type="GeneID" id="30195954"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="56"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="506" mass="55405" checksum="8328CEEFA671D9AF" modified="2017-01-18" version="1">MPRTTLIRNASLVGYPAGTYRVLVQDGLVASITETGTDNAQAGEIIDVKELGSQWVSPSLVDSHVHTSLNALHSHRLDLQTAKTAQEVLDRVADAFNDPKYRMVEGCSNFAGTNMRNAGWPGPELLTRQAIDAISSERPIHLFFNGYHSLCANSLGLKLGGHEPEGHSGYLYEEEAFTMARVIGKVGADAMDEWVMEEARYAASLGVTEIVDLEWELGIIDWQRRYNKGFRSLRVNVGMYTDHLQYSIDRCLKSGDDVPDTNGLIKVGPFKIITDGSLGSQTAFCHDPYPGSKDNFGVFNYEPEELGVLIKRGADNGFKMAIHAIGDHANQLTLQALSRAEKILPGSTIEHAQLLSPSDLPLFASLGIIASIQPCHLVDDRDLCHKFWPGRELGAYAFRWLVDAGVPIRMGSDCPIAPLQPWEAMAVAISRAGEGDEENPFCKEQIIDLEVAWAASTSNNKMKLEVGDRADLIIINADPLSCDAAGLRAMKVKGTMLGGDWTYKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJH9</accession>
    <name>A0A1E3IJH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle arrest protein BUB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029317.1">
        <property type="nucleotide sequence ID" value="XM_019178616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJH9"/>
    <dbReference type="GeneID" id="30195773"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="50"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="308" mass="34776" checksum="5D8F720DAB175636" modified="2017-01-18" version="1">MPSSTTLHGLLSNILDNSSKSARHRASTDIPDGLKRIRRLVLTEGIPEVPGKPPLRARIWKLMLKVDTLNAEDYLRWVSMGPSSDSHKIKNDTFRTLATDTQFKGKVKEDMLIRLLEAFVWKITSTESEDDTQPFKYVQGMNVLSAPFLFTMPSQLEAFACFSTFIENGCPLYVQPSLKGVHEGLKLFDRCLEIVDPELYDRLASKNLKAEIYAFPSVMTLCACTPPLEEVLQLWDFLLCFGLHLNILCVIAQLLLIKQDLMESPSPMKILRTFPPLQARPVIGVTVALVKDIPEDLYRELVAHPYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJS6</accession>
    <name>A0A1E3IJS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029401.1">
        <property type="nucleotide sequence ID" value="XM_019178700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJS6"/>
    <dbReference type="GeneID" id="30195857"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="551" mass="61752" checksum="D90100E0CB1F24AD" modified="2017-01-18" version="1">MNEDHSTPNQPKQSIVHPIQLLPTATNQNPPASQGPNTMDRDTSLPQAPPHATTVLEEGLFQNERLEKWANIKVGQLLKVEHPEPLSLNGNRTPYYSLMNRVHEGSYDPNVKAILFDGRPAPEVSVRKDLPKHLADLEEQTFPPWVSVECSSGGGWSEGWLPYTRPSQYTRSFAANLLHLAAQELKYRKDIGKTVDLINGKKSDEPATVSFEQSTNATGGISTPLPPRSRSSSEVSSMFKAPEEHCVFYTFALRTHLHYKDSIERHTVYERALLVADFKRLQVDPELEVTDSEYEAKVRYEKGLSHIIKQLHRAWERFGTVGLFALGPFFLGNIAVECKPPAGVGPECFDWDVNNHHSPAAFFEKFDRHTLPHTFLLPYSTNHELAKQLGVRAPLPLLNLEGLQMFEHVIMRTYASVPEMSIEEALGKRADSSHPSTAQPQPGDRSPIQWYLSARWDVSPMVEEQDVKDLLEAFNAHVSGGGAGQHEGEIPETGLRGGLESEETQKIAGGARRESVEQWLCSHSLCTRSIPFPTFRKSDTIACCLNYYRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKN7</accession>
    <name>A0A1E3IKN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029448.1">
        <property type="nucleotide sequence ID" value="XM_019178541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKN7"/>
    <dbReference type="GeneID" id="30195697"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="38153" checksum="E71250BE3B63DDF1" modified="2017-01-18" version="1">MTSIPKTMKAWVQNESNWLSVAEVPVPQPKDNQVLVKVQYAAQNLTDWKHSAFLSLPGVINGCDFAGTVVALGSNLASPLKLGDRVAGTLHGGYYKDEGSHAEYTLADSDLTWVVPEGLGLAEASTFGVAWVTAAQAMVQHQGKAFPTLGDTNYIVYGGSTSVGLFAIQLAKILGYQVLAVASPHSFPLLKSYGADAVLDYHTPDEAIAEALKITDGGVELALDTISEGDSFRITVGMMGKKGKQLNALLAVPDKVKELNPELKTEFTVMYTLLGKEFELAARAPGQLFFPSVPEDRRFGVEIFQQTAELYSKYGLKPNPVQITGGFEDVTKGLELLKNNKISGKKSVIRIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKP4</accession>
    <name>A0A1E3IKP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029454.1">
        <property type="nucleotide sequence ID" value="XM_019178547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKP4"/>
    <dbReference type="GeneID" id="30195704"/>
    <dbReference type="OrthoDB" id="2563136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="261" mass="28061" checksum="0CF72C7348331E3A" modified="2017-01-18" version="1">MVLPEADISATPIDDGSFVPSQPQKKDPNDRSFQPNSPKLVIFDQRSGEKETIDLGKASSIMTMEDYRTLTRKCTERGMFGGLVGGGILTYLVKRFKPTPPSRNALALTFFLSASFFSFSSSRALLVSEILKIREKARAMAIQNGDIPDPAENLWGSDDPNVAGARGMGDSPRNLPPIPQATAPDPSLVGSPGPRGYATGQSGRPSGAVREELARARLGASPDRAKWAQERNQPREQFEGDVPGPGEGEMVDPYASLGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL88</accession>
    <name>A0A1E3IL88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">STE/STE11/SSK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06528</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029490.1">
        <property type="nucleotide sequence ID" value="XM_019178583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195740"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1485"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1514" mass="169224" checksum="183D8BE5616FC836" modified="2017-01-18" version="1">MRPDAHVLFLSPSFSSPILSSPLLLPLPPRRACLPPARLGTHDIPAAPPQQAPIAAVGDTMPSSIPLASPISPPKHSDSQASNPSSLNGSSSKTGRRSVRLFAPDEESSSDEEGLIGVTSPETPFSKESELPPSNQRSSSYPGPPTHTSPTSRISSIVSSASAAQPKLARSVTYAPSSVNFRPSFPIKPNSPEPTHSKTYESWKKTRYGPNNGGREVRGERHGQGRGRSYADPDASYFTNGEKDEYGSDEEVEGARSPGWNMLNTTGNVDISPLLSIKAADVTEDEGQERIDWQGMLESVLNSDVLKLEEARISQTMPTDSFKEEFGRALWWQIRAKLRGRTEAEEKKRVHERRARVVDMVLEEVANFRYDPELVLDTTKGDDHEDPQDALSKDSPQSRALAQVNVALAKLGAVKALYPNLAAMRDDKEIYTSADFRSRADALTAWSIVVSSLQTQLRLLQKWTGSDDLDITKPNTTKEKALVGKYRYHPLDPKANHPGGDAADDSSFLDRVMKEDNLQRTFERRAFVDMINLIRNAKETVIDYSPFFEVQNLPDFQYEMVRLIGFPGRLIIEAVKVRLDAAARLVDPNPMVVADFIENLRLSISLAVLIRKQYEEIMAPDPKGRWAMPPCLPVEYNDVLLDALRAFFKLLHWRLRGVGRASYYKETEVLEEEASFLYEAAEAIEGGDMVVAEQYCALSNKLLIRSANYLDQQLRVPLHHARDRNERDRERDRDPLALSKPGNMKLEELFSWYSKLLDSARMRHRKTQRFCRKLTQRFDNSAEYSLEETDIDPLVETLQDTGHFLVYTNQFESKGTYIVADGSLWGLPDEVRRLLHRVFTLGQNVNGAATPPDPADFEAEDVEDEAIAAYLLLISPRQNFVWSGAVMTLDVDYIEYDLADNRVRLIADGPTKRLLLCKHYFAEALLNPETGEQSINLPCVVEAQAHLPTIQRQLIKIAKSSYRLSECIVQSAPLVRNAFRGQQGSQELVENWYSFATEHGTRASIHVDPSVWERFSRLLMRLAISWISFISQECNPTDRKTFRWTVAALTYAFNMTRGNNILALDRSEFSLLRRYVGACVSLLISHFDILGARSSLEAKKEAERIEAMRRLQRLQENLDDEFLPRTPSPSGQPRLDRSIRLTVEERLRLIAELEAGRKDAAPAAVGQVLDEEVSEDRALVFLAASKSNISMRWQQGAYIGGGASGSVYLGYSLQDNAVFAVKILPTVDLQSSPSLYESIKRESDVMSLLSHPNVVGFLGLEVHRNRVCLFQEYCEGGSLGGMLEYGKIDDEEVVGAFTIQLLRGLEYLHANRIEHRDLKPENILIGANSVLKLADFGTAKIIKSNKTLARTRGGAHAKMEGLEGTPMYMAPEMIKNQQTGKLGACDIWGLGCVVLQMTTGRKPWSFLDFDNEWAIMFHLGATTEPPPLPDPNEMSDQGIVFIEGCLSLDPEGRPMASDLLQDIWLAPMLEQMAELEMEYPDVLAQHDSAGPLPEDTSLTSTPSFIEDATPPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILZ0</accession>
    <name>A0A1E3ILZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029523.1">
        <property type="nucleotide sequence ID" value="XM_019178367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILZ0"/>
    <dbReference type="GeneID" id="30195513"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="452" mass="49614" checksum="0A9224CCD8BF8C28" modified="2017-01-18" version="1">MVYQDTLLSHRPREFSLAELPSLPSESDPSSSLARRKESLIGKADLATSSNATTRTLPPVPNGSEPPSASRPPESGTSGSEETITRRRRTGTRTERDRVVIQSSNDSKGHKSSSRAAKPLEPQLPSAPGLLRAPASSMYFSSVPFYGSPPNQALRAHTGTLVGERIWIIGGVDRQNCWRGVAWYDTESYMWSTIETAGGQFPPLRAHTTTLVGDKLFIFGGGDGPTYSNDIWILDTSTHRFSRPVFDPNMSLPPPRRAHTTVLYQHYLVVFGGGNGQAALNDVWALDISDLDNLVWLEWKTKGDVPQKKGYHTANLIGDKMVVFGGSDGHASFADVHVLNLQTCVWTLVNTDIKHNRLSHTSTQVGSYLFVIGGHNGQAYAQDVLLFNLVTLQWETKVPRGAFPPGRGYHVALLHDARIFISGGYNGETVFDDFWILDLSASAYLPQVVNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM85</accession>
    <name>A0A1E3IM85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029619.1">
        <property type="nucleotide sequence ID" value="XM_019178463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM85"/>
    <dbReference type="GeneID" id="30195615"/>
    <dbReference type="OrthoDB" id="2572856at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72343" checksum="14D7B6688CB922AE" modified="2017-01-18" version="1">MHYPRVRRYIDDVCVREPAFYADHGGPGWYPELQHPNQVRLAVQYNPLLKEDVYIQPNSLFFSGLKDGLSKGDLRELLDEYGVERGMEFALFQPHKQIHRTSMGIMIFPSQRQAEDAMYVLNKNSNHLGVSRGEKRADFRVRYSEINSLGHRQHDISDILLVRENLSISDAYIPTYIPESNDGIVAHPSSPTGWHAVGYSRDEFTTKRKAQDLDKLPQDPRKSGKGKLAAEDTPSPPKRRTLEPVNKKASDETEEGVGKENAIASKMRAPLQPVGLGHPSASQLPPVPQHHPHTSTLDAIRGPFRFTGSKDSKKKNKKSGRRPRSPPYYRRTSPDNPNLVSAPNGNRPTSRRMSASPYSIIPDCPELSVLSQDQKKVLLDALHLLGDTPKQVKGREVVLDTPSQAEKFARAQQAAREQRRKPVAPILNDSAPSDSVKEPKAMRTPAEIEQQARPTSSSPMPQSFIPTGPANTGTTFSPLPKGDSDRKSKPGVNHSDPLEAGEIREHEDVSAEAISDQSLLDGAAAEALPARPSFTAHRETLSLSALTKFSHHLHPNPKVGSYREPRFVALSPGGKTLTLSHSTVNTRVSRAQQQDEFPFENLSDVQRRILGVEKRWVLNGPAWEKWKESREGVVVLDAGVEDKIEGGRTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA3</accession>
    <name>A0A1E3IMA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029557.1">
        <property type="nucleotide sequence ID" value="XM_019178401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA3"/>
    <dbReference type="GeneID" id="30195548"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129827" evidence="2">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17051" checksum="7B49A40F809D71BE" modified="2017-01-18" version="1">MVVLSASWLLAGFCVLPLATAYPASADTSIEDHSLSSSLSSSSPESTSSGALHPGQDRPRFMSHDTPSDHYPLDSIWWQASSHHIPRTVVLDSRRLAEAKRKLEEGQAEEQIPLWRRRSPRSDDARRSPPGVEAACAEPRDWRYVSWSLSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INQ6</accession>
    <name>A0A1E3INQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIF4G/MA4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029762.1">
        <property type="nucleotide sequence ID" value="XM_019178324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INQ6"/>
    <dbReference type="GeneID" id="30195470"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="648"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="871" mass="95960" checksum="37546A5D3055863A" modified="2017-01-18" version="1">MAPFGGRGQSSGGYGSRGGGGSRGGGGFRGGGRGGRGGFRGGRDNGPKLPAELLEQVDAKYGSGGKRDISRKEKRKAARDDKRGPAQRSRRASPSEGGEEEEEERPPAKKAKTAPPPVSSKGKEKEGEKKEKKKKLPELTLPGTDTNNDVEDKEIAWLEYMLKKEKKPKDEDDLEDGLDDLLDFTEGLGRKGSTAKGSMLDESDDGFDSDEDEEEMVDLIEDEEEEDEDQQSLKESEDEGEFQGFGDSDDAASEPGLEDEDESPPQNPIDPKAGEAASDDQPAPTKYIPPHLRAAQLAEKAKGDKAKIEARLKLERKAQGLLNKLSEQNLESILGEIEGLYRDNSRNDTTTTLTDLVIQMISNKANLLDSFVVLYATLVGALHRIIGIEFGAHFTHTLVMKYIHASSSSSSSSDDITEPKESIIQATIYETPDAGKEALNLLTLIAELYNAQVVGSRLIYDLVRGFIDSEGKEGEVMGEREIEGLLKVLRCSQLRSDDPSSLKDIVNLVQAKTKGKEKTMTARARFMVETLVNVNKHGKLRAGAEGEAGNEAAQRMKKFLSGLGKKRRLLTYEPLRVSLSDLTSADKKGKWWLVGAGWSGNPLVDLEQQREEARAGKKTKKNAKGQDAEKDNEAALLELARKQGMNTDVRRGVFVVLMTSEDYAHACDRLSHFKLSDVQQREFVRVALHCCGLEPTYNPYYTLILNHLCANSYDHRFTFQYALWDFMRELENGSTVPKQKLGNVARAVAYVVARGGVDLTVFKAIDFTALSKPLTKFLTTFLPFFLIALQSISPIFNLPKAFKQVEFDEEIVKERFEKVLSHSELAGGWLWVLDREMKSGGRWEGEVGGGREREVVMKGVEIAKGVLGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INQ8</accession>
    <name>A0A1E3INQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029744.1">
        <property type="nucleotide sequence ID" value="XM_019178306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INQ8"/>
    <dbReference type="GeneID" id="30195452"/>
    <dbReference type="OrthoDB" id="6088208at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56569" checksum="482D9B7158D1D1D1" modified="2017-01-18" version="1">MSADTPSKIPVIRPLPHSRSTSSLGPHPQSPTSPLGGAMGRASPAPGTPILGVGGRRLSLVNGFGTGQGAGAGRGAHIRTRQGSKAGSISEVLEDDPAHLKAQIQSLRADLDSTKLRLLQAEASRATSPTLPDVSVGTPLTVSLIEEEKRGDRNSPLDHEPPTRKSSESGSRPSSRPSSRGLPHSNGSYDLKVHADTPKDGRSRIPQAVVSHATALHPTPPISNSSRRNVSSPSPGPHSPLSDRYTTRSPYLAVDSPSPNPFPFSPLAHSTSSGLGRAFSPSPSPSSRKTSGSASTKVIDSLQTELLNTKTHLERVKSEVRAGQRRVEQLTRQKEDLQETKERMRVENEGLNNVIARKERLLQEVLERARTAESAFKEISSTRKTLEQSTKKSLTDMTAQLQEAKMREMKAEREAQSLKDGVQSLKDLWARDVKGVREEMKRAEEAEREKREEDARKREEVLKLVETQATERAETENVARDALSKCAQLTEHFEERFSGLRAEAEKNGKECQKANARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ59</accession>
    <name>A0A1E3IQ59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029842.1">
        <property type="nucleotide sequence ID" value="XM_019178123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ59"/>
    <dbReference type="GeneID" id="30195268"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26682" checksum="713B8CAFFA7E4B3F" modified="2017-01-18" version="1">MSRLIVETENNPNQPRFLEGNPLLSYLECAAEYGDMDESLRAQIREKECWPALADEFGQDRILQTFLKTTQAVDIFNGGIKYNALPEMDFFEATQNTLKRLDKILRPLAAEYNMSFASFGETPTTDENLIQLDTMGIRLEPAPITLPTGHAWDLMGGTIKHIFPGAVVVPSGMTTFADTQYFWNVATHIYRFAPASLEIIKNYHTVDERIHVDASMSTIQFFYKVMRNSVGWQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ90</accession>
    <name>A0A1E3IQ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029854.1">
        <property type="nucleotide sequence ID" value="XM_019178135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ90"/>
    <dbReference type="GeneID" id="30195280"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="241"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN90752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="36439" checksum="26E02B45338F073E" modified="2017-01-18" version="1">MALPLPVSTAAPISPPASKLNLQASHHLASGALSGLSSAIVLQPLDLLKTRLQQSQGGVANKRQRLRGVFTQVLKDDGIQGLWRGTVPTLVRNVPGVAIYFYSLSHIRNRLSHIPYFAITVPAAPICDSKSPLGVKTEGGSRSAIVKLSSGGNLLAGAVGRTSVGFVLSPITVVKARFESSRYSDYNSIFGALSSLYRTQGIKGFFQGFTATAVRDAPYAGMYLVFYEKCKEVAGKLPGVPNAAIHSGSGVMAAMLATIITSPADVVKTRMQVNPAEHPTLKKAVERIIQERGIAGLFSGTSLRISRKAASAAIGWTVYEALLIFLRDRKDHEGQTTQLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IR60</accession>
    <name>A0A1E3IR60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029723.1">
        <property type="nucleotide sequence ID" value="XM_019178285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195431"/>
    <dbReference type="OrthoDB" id="3365519at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1731" mass="185608" checksum="C2297A27C4891128" modified="2017-01-18" version="1">MSAEAPAPAQKKGFFHRLSVATPSNNPTVSPNKLGKKKDQVKAGPIYEELSRPLSGMDSGPSAYRDGAQGGVARSKSKDRSFWGGNKGRSKSKSRASTPNTIPPPMPTPPPQTTPIAASFARRPEYDSSPSSSYNNPAPRSGDLQPSRHTPTEGSSARRPDTNAKSNTGYGDDPGAPPPKQKLRQGDLQPTRQTPAPAKPLYPVDPSFMPSASASGSLGGPYPSMSGTHPYNQFARPVGQLGQPPMGSDNGPYPTVNRAPSQLQQPQSYQPQPAFKPFRTPSQNRAPVHPALASSPSPPPVASPPGSQSGHGHGPRSPTYGSPVEMQPGMVSSGMAEERRDRDRGLSRQDGRPHPQPLKPQPRSSSRTLTQSDLRSPPSTTKPLASPPPPLPGQGESIPPMPSVPGVSPRGASLGAAPGAAVSQEHGGRRSRPGSGDRPVVPPLVIPSDPHQPHPQASRQRTPQPPPETRPEPTATRSAPRAQPTSRGREDHRQSRFDDALTDDTHPLPDAPPAYTPSPTIVAQNPKERERYQPPVPTLEAHQAEASRMRGVVAPNLPPGAAAPEAASPIGPSGQAWSLGNAMGPSAQTADPRAQLLSNPPAAAQSDRQMERIPPSQVQQVDRHQGESPRRKPVQPAQPHPHSRNGTPGPAKEMSEASKYAQSVAASIKHEGVSSNPSSPTPSAAIVQPRQQQAQVPSDRTPTHTPTRDKDMERRFRHAANASIRSVNSVGKDGSPNRRPLPQPPTSASGSPAVSPVRAPQLPPIQTQGQGQSVGQPNTGVAMGSPLKDMASPTRPNFAAPPSEVRSEMRSPVEERVSRRDVERGRTMRSQDIPPPVEKSFLAVAPTPEPKKIAPSIEPQPQQVTPIQNKHIQKPKESPLAFDFPRSPTLPPLLDPRNNPNSSSVATSPLASPSTAGLETGSGAEERDPIARWAASDEKERMIREMEREERERERQRKESERSGRSAASGRSGQSSLSRETPLVSTELPARGVSPQSSQSQLGYFPPPQQQVQPGRRTVSSPLNGRNSPRITSPLSVSSGQDRRWPGQAPDVQGSRAVSQPLPQSSSIPTLPPLLSMDAFQEVKPRGERPPATLTFILLYTPIQSNLLQYLSINSFLSLTGASEAVNRRFSGEMVGRWIMREWGMSVGKKKGSYAGNVAWPNLTVWEGFLESLLHDPASYSTYPEQWHHLLKHLSLSHTLVVLHLRSLPQDLFPSPPPQPFDDDAGSIAGGMPNLPFSSSRGSLSSQGRQSRVGSMVGLDAASDSLKMPKAERIVELIMPEPLAAQPRDESPTNTPASKKFPPLSNSSVAAAKLRRRGSVTSLTSTASMPFLRSKKSSSGSSAASIANMPFHNPAEPMPPSGKASLPPVSYPTAKRYGFRSHGDPTSKRTSQSDSRPSSIFSVQSSASMSQLNNINRLGGSGASSASFAVDRHAPPVPGFPANLPFPPPIGGGAGKRGSFSSSSDLGKSSRRSDYGGNSPVDAINRQFYTPSPVVKRIEPAFDKPIPYILGRAPILRVFVPLSQTVQRWPSIEGAAAAVRELEKCGAMKRLKLGDLVANTAINHPKTTEHVLIYVPYAQHQLLPLSYAFSVTGTLPMNIDAFKLPPSYYFTFLPVTQIIYLDLTPYGRDALSSLRLAYDRRDMTVSSGARVNAKRYLHIAGFEVRAGTGADAAWEGFVSLEGEGTAEGKRDIEKRLVGDGRGGRPVIGAWEIVREKCMVGNIWLKLVKEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRV5</accession>
    <name>A0A1E3IRV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029970.1">
        <property type="nucleotide sequence ID" value="XM_019177931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRV5"/>
    <dbReference type="GeneID" id="30195067"/>
    <dbReference type="OrthoDB" id="10406957at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="24207" checksum="E3D76BE7525D8D58" modified="2017-01-18" version="1">MPEQMGTPNNSTTCAGGNVKSQQSTIWPSKGKEVEIKVVSADGIALYVPEHLLKSHSEVLRSMINDIGSTDTRLIEFSDPDIEGYKTLHLFLAVVTQNSLEGAIARDETGGGRGETLLSALDLPHIAAKVIELYTPKTDAADSASKSPTSTWPFLLSGGLVDIGKLEDEAWQVIPGKYLRALHRASTNSAGARLCSYCNDYTSKEANSAQRAAKFLEEVTGPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITT7</accession>
    <name>A0A1E3ITT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030177.1">
        <property type="nucleotide sequence ID" value="XM_019177793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITT7"/>
    <dbReference type="GeneID" id="30194927"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="154" mass="16720" checksum="2D1A1C94BEB14F83" modified="2017-01-18" version="1">MQSINDVVESGKVLYLAWIVSQANEYARQHGFAQIVVYQGLWNVGTRDLERDIIPMCLANGMGLAPWGTLGQGKFKSPEELQKQSNWRCGAPSSDRDIKVSKALQEVADEVGGGIRAANAALAWARQSFADCFPISGGTNPEHLKSNIEASLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVX7</accession>
    <name>A0A1E3IVX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030335.1">
        <property type="nucleotide sequence ID" value="XM_019177584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVX7"/>
    <dbReference type="GeneID" id="30194715"/>
    <dbReference type="OrthoDB" id="2595178at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="60000" checksum="02D8E1376C734BE9" modified="2017-01-18" version="1">MPFPDRRHLSPPPHLPDFPSEVIRRIIYFRLSLPPSFPSPVAAHHETAEIQPSWDCWAGAKGREVDCKLIKARKDISKTALGLLFVCKAWKPVVLEYLYASPHITDNLTLLAQAILRGDAKWSDINIHKFSLPGRYLTTLDLSHLPPEFDRYAPGPIATRQGVLSIFPLLPNVVHLKLGEKDCRRVVPLEEIGYSAFASKLQSLEGVWVDERERGGVDLVRLLRRLPSLQALSVSGPGIAVEPSDLDGAAPLSLPKLHSLKLEGIPSGFFISSLLSASLPSLTRLALTPTPLLPNDQSLPLQHSLSSQILSLSYLSPRGWPKADWGIPPGTLTIHPNLIHLAVLDQDYEALDILLRSSSAHDHPLKALTVQKWSPSTFPSPTLSLSSSPPTAPSSIFPLSPPPSPPLAGSSSPSRKSGPAFLHTILSHRSPAPKGLKTITIDGFKWLNPSLGVIAMQAGQMGEMRYQANLLSSQKGIEVRDMEGEKVPALVGASPVGMGGMGMGGMGGKGAMAIRGRRGSGTGLQGRWMMMSPPREGGLRERLQEKEGWDEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW17</accession>
    <name>A0A1E3IW17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030441.1">
        <property type="nucleotide sequence ID" value="XM_019177690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW17"/>
    <dbReference type="GeneID" id="30194823"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="219"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="51181" checksum="C473242E9C0983F7" modified="2017-01-18" version="1">MSSLSPTQSPSAPPSLLHSIGAKASERLPPGLVYFVSQNVGLTLVAIAELFFVLMGLTVKYFLSNTEISTFTLIFVRMGITWIFCVISLWLVKRDPNPLLGPPGIRSILVLRGLFGYFGLLAGYQALRGLTLSDSLAIQFLAPSFTAFLGFVFLHETLSRKEVIAGCLCFMGALLVSRPRFIFGDVSEEKSHHGGGRLDLPPAPGGEEDGVQEIARSAAVAWACVAIVGASLAYTTIRWIGKQAHALHSISYFSIMCTVASGFWLLVRPEPIAWVHSLSDLFFILTIGVFGFAAQTFLTLGLQREKAGRAGLAIYLQVVFSLILEFVIWGTIPSLLSALGTGLILCSAFWAAFSSTPKRENAKPTDPETLPFSREPSPIPPPNTTFPSRPGAETHYSYDSTPNWLAPTPPNGLVRASSNAVNSGAGSREGSGDGEGGTLDIPGRLKAGSRTGSNGSLGGTKETRVRKQSGTGSERQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXR7</accession>
    <name>A0A1E3IXR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030538.1">
        <property type="nucleotide sequence ID" value="XM_019177385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXR7"/>
    <dbReference type="GeneID" id="30194511"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN93433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11059" checksum="DD91109B438C7934" modified="2017-01-18" version="1">MSGQAKTTQNAAAGPSNGAAPQEKKELPKLGALEDDDEFEDFPATDYGGNVQDALKKSGAGPNDKLWEDNWDDDDVDDDFTKQLRTAIQERTNAPGDEAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXS4</accession>
    <name>A0A1E3IXS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030333.1">
        <property type="nucleotide sequence ID" value="XM_019177582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXS4"/>
    <dbReference type="GeneID" id="30194713"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="180" mass="19663" checksum="AACD67E76C2EC1D4" modified="2017-01-18" version="1">MSYPPPRAQSPLSRGRGASPRPPPSYARSSLDRPSPSLGPRNLEDELRPGVPPPIYVRRSGTQTISGKGILKIHVPGWACVLLRPPRLLDLHPLDSNNGERNPPSNDTVLTGVLEILMTERRRVHAVSVGVQSVARLHLGQGRGWEEDGIFERGVEVLGGNEEGIWLEKGTQSQVHVSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXZ3</accession>
    <name>A0A1E3IXZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030592.1">
        <property type="nucleotide sequence ID" value="XM_019177439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXZ3"/>
    <dbReference type="GeneID" id="30194565"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="41001" checksum="55DFDACDFB92CCE4" modified="2017-01-18" version="1">MAEPMDVDAPQQVPPPAPKPKNAMEAMMANAKKGKGKETDAAQPAVLDDGLPWVEKYRPVSLDDVVSHKDITGTIEKFLDAGRLPHLLLYGPPGTGKTSTVLALARRLYGTAYKKHILELNASDDRGIDVVRDQIKNFAMTKVLFSKGFKLVILDEADMMTQAAQSALRRVIEQHTKNVRFCILCNYVNKITPAIQSRCTRFRFSPLPESEVKIRVDEIVAKEGVTMTKDGEAALLKLTRGDMRRALNVLQQACHAAYDIVDEAAVYNCTGNPHPKDIERVVKSMLQDEFGSAYDAITKLKIDKGLALQDLIAGAYDFLDTVELPKQSRIYLLDHLGSTEHRLSLGGSEKMQLTALLGAFKVAVELSQKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY09</accession>
    <name>A0A1E3IY09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030584.1">
        <property type="nucleotide sequence ID" value="XM_019177431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY09"/>
    <dbReference type="GeneID" id="30194557"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="60"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="253"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN93479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="545" mass="59416" checksum="CC32F8903752128D" modified="2017-01-18" version="1">MPIAIPSRSLSSAADGQPIKARSASPYPTTSPEQNLLRLKAHLQNLPTPLLKNIHLAKIRRSDPNAFFSLMRDELIDYAPIVYTPTVGEVCQKYSQIYDGPEGLYLSIEDKDRIPEILREYASNLSNTPQILVVTDGSRILGLGDLGIGGMGISVGKLNLYVAGGGVNPHGCLPVVLDMGTNTQSIRDDPLYIGLRRPRATLEEATEFMDAFMAAASEAFPKAVIQHEDFYSEAAFGFLEKYKEDYRMFNDDIEGTGSVILAGFLAAAKQASEASGKPLKDHRIVFLGGGSAAVGVAKEMMNFFRMQGLTEDEARERFWLIDTKGLITSTRPDVVSGKVSSHKKYFIRNDTEGKEYPSLESVIEYVKPTALVGLSTTFGAFSEPAVRGMAELNETPIIFPLSNPTSKCELSFSDALEWTDGRVLFASGSPYPSQEFGGKFREPGQGNNFLVFPGIGFGALQAGATRITNGMITASAISLSEALNAEEKARGLLYPRLDRIREVSARVSAGVVKRAQEDGVDTNTELRGLDIDALTEKMKSAQWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY41</accession>
    <name>A0A1E3IY41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030642.1">
        <property type="nucleotide sequence ID" value="XM_019177489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY41"/>
    <dbReference type="GeneID" id="30194615"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53295" checksum="08D963B9DBA73941" modified="2017-01-18" version="1">MSFLSPESEAIIKARIKTTLVSCSSINTPHVPSGTTEIPVSDLGLMAYLTVPAVLVFDGLIDETRLVKAVELLTSVWPTLAGRYKSVGEGDKTKFSIELTSSPIPFETQTLERDRAFSDNYVVQPTLDPYLPPMDPNVRYPNTDNYLFAVRLTTLVPANKSVLGIQVCHLGMDATVGRNLLKLFDALYTHGEAALDSSDPQVIIPTFFPVSGVEPLPASEQYLTDDDVFGIPSKPFPKSIQSHVADVMTSSRVALRFTKSELQALRDQYQLDSVVKLSTQDAISAWWATLLNNVGVNVETLVYILEYRTWCIGHPSFPSNLPSLAAVVCSISPIDISAVTTPGRVAQAIREHITKLRSSENDEALHWISRTARHLYESAIQGRDMVFSGDEEQSAKYAIVNSNIRIDWFFSFGFKEHQVSYHTEPTCSRYLRVYQANLQEGDEKGDNVEVYFHVPNEQAEKAREIVQCDRAKWVAAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYF8</accession>
    <name>A0A1E3IYF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030368.1">
        <property type="nucleotide sequence ID" value="XM_019177617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYF8"/>
    <dbReference type="GeneID" id="30194748"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF61">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="61694" checksum="EA1C12B8C39541A4" modified="2017-01-18" version="1">MGKSGSTQKAVENRREADLESGQMSSDEGTTLHPSESGSGHKRGKIDDKGREIIDWDGPDDPDNPFNFSISYKWLLTITTCFISILTGLPAGAYGAGNEYMEEAYGIDQTNFPWLQWATCSWNIGAATFPLLFVPLTEKSGRMPGYFISYIVFLIFLIPSGVGTNFATMIVTRFFGGGASSVSINIVGGTIADIWKGPKERSIPMSIFGMTSVVGIALGPFIGGAIQTNHSTLNWHWIYWMQLIFDGALLPVFWFILRETRGDVILAKRAAKIRKETGREVYAKSELKRKPLLEELKISFERPTKMLVTEFVVAAFTLWVSFAWGLLFLFQNSITQTFQTNYGFNTFQTSLIQLALSVGAVVGTIINPFQDRMYLGSAARNKETKEKPIPEARLYFSMPGSLLFTGALFWYGWTSYPSIHWIVPTLAIGFIGLGIYSIYMGTVTYLTDAYEKYASSALSAASLGRNAFGAFLPLASQALFTNLGFHWAGSLLGFLALALSGVPFLLFYKGEYLRHHSPFIKDAMFDSPEQEEEEKHPADIANIQTVEGANRYTAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYL2</accession>
    <name>A0A1E3IYL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CK1/CK1/CK1-A protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030620.1">
        <property type="nucleotide sequence ID" value="XM_019177467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYL2"/>
    <dbReference type="GeneID" id="30194593"/>
    <dbReference type="OrthoDB" id="6511923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="41841" checksum="1EBA44396D0145F1" modified="2017-01-18" version="1">MYARKDIGEVIGGRYEIKEVITHRDCEVSVYVATDIQTQEEVALKLNTAVHRVQRETKFYDDSIRDLEGFPSKRWSWEHDYYCFGAIALDRLGPSLDTLIKEVEESKFSLKTTLQIMDQVITRIQALHERHIVHRGIKPDNFCIGLKGSETENKVYMIDFDASKKYIMDGVHIRNYGDNDVGNRFWTSLAIDEGSKPVRRDDMESAGFLAIYLLKGKLPWLCEYRSSAVMRGKAITALQELCKDLPEEIITYITYCRSLQFAQEPDYGYCRELFRQVFEREGFNDDGLCDWSTPQLVAESDSMEIAHGSDDDLPSSNHSEEDSSATPFDDDTVDEQTLVTDHTETTEACSAQYLNLRTRQVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYN2</accession>
    <name>A0A1E3IYN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030640.1">
        <property type="nucleotide sequence ID" value="XM_019177487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYN2"/>
    <dbReference type="GeneID" id="30194613"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="154" mass="17053" checksum="64ABD364C40196C2" modified="2017-01-18" version="1">MQMCQYCNTAGSRDEHHHPNALSDTTTIPIADVSLWAVGAVQSVLCFEGALDEKRLRKAVGLLSGVWPTLAGRYERLRLTSSLIPFETPTIESDQAFPDKHVVQPTLSPFLPPLGKNYHLPNTDAHLFSVRLTTLLPSGKSVLGVETSHVFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J064</accession>
    <name>A0A1E3J064_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05129</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030804.1">
        <property type="nucleotide sequence ID" value="XM_019177223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J064"/>
    <dbReference type="GeneID" id="30194342"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="302"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="57453" checksum="335F312B752D169F" modified="2017-01-18" version="1">MATEQKENLFPTLGEVADRTGAGEGEEDDGQMQDVESLCMRCHENGATRLLLTSIPYFKEIIVSSFRCDHCGFRDTEIQSAGEIQPKGVSYTVHLLSRADLDRQIVKSNWATITIPDIQLTIPPGRGQINTVEGVIRDTVRDLNISQPVRRVMDPETAGKIDTLLEKLRVAIDMEDDEDEDGGVGRDDEDEKRAYQESKPHEEKPFVPFSMIVDDPSGNSYFQFKGSQSDAQWNMRAYPRTFEQNVSLGLVAANEEGEKQEEPVVAEDHKLGSVEEFEEKRKQLMAREDGTVVPDEVFTFPATCSSCGHPLETRMQQVNIPYFQDIIIMASNCSACGYRDNEVKSGGSIAPRGKRITLKVEDEEDLSRDMLKSDTAGLEIPEIDLVLQPGTLGGRFTTLEGLLNEIYTELSTKVFRTGDSLTSGLGQISKEAGSEERNFEDFLKGLKDCMGAQRPFTLIIDDPVSNSYLQNLFAPDADPNMTIEEYDRTFEQNDDLGLNDMVVEGYNEDVKDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0E6</accession>
    <name>A0A1E3J0E6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030881.1">
        <property type="nucleotide sequence ID" value="XM_019177300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0E6"/>
    <dbReference type="GeneID" id="30194421"/>
    <dbReference type="OrthoDB" id="2570070at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="42159" checksum="94C0A6BF534CA57D" modified="2017-01-18" version="1">MSDPVLSPASVPAPTPLTSTGFITYRRQLLSYLATHAPDLFYHLYPSPAIEPYRKTPSSLVHLVEMALFRPWGQFAGDHPPCAMVSVTGLRLSEEQFLEWADWARCERSLRKVFRKTFSPGMWEGMGNMWSTKDIWETLEAEYTPSPVERQSHIIYCLRSTRLPPQASLRDIFKLWDTFNLLVIESRDAGLFILEEEVVDRYMGAIGSGEAGKLVRATYGSMSKDEPLKGTWRGARRAVRMCIKKQFDDHQLAISGHPVPIAKSSTLMPPTPEYDEPLSNTEPNLPPTPEPTPRPATIPIAPDAYTIVDRVKDRRRGSTRTALSEKDSNALASPVPPKKMRREIEEVKKDGGDARHRRGESLARGEMREVATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0Q3</accession>
    <name>A0A1E3J0Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030646.1">
        <property type="nucleotide sequence ID" value="XM_019177493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0Q3"/>
    <dbReference type="GeneID" id="30194619"/>
    <dbReference type="OrthoDB" id="3058553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="590"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="686" mass="77963" checksum="E40D3A9A1942DE17" modified="2017-01-18" version="1">MATRVARRVDDVTGVVQKDKGTDKQQSIAQYTKAQYSKADCFEAALDCLIDLNLPIMTVDRPVFRHLMLVCGNGRLQDGDIYHRTKATSMIEDRADVAVEELKALLKKAHAKKSITWDLWTSADCTSFVAVTVHWVTNKFKITSDLLEFKELESAHTGSNLAELLYQLVKEYDIAKSLMVVTSDNASVNDKATREFANLLSVRDNVHYTEDRLRGRCFSHIIGVALGHMLVAMNALPSFEFSPLVDSHFFEPETFEDFFPFGQTQEEDTEVDAEELEAIWSALAEHGSEETENIERVDVGKLLAKIRQLIVKVRGSPNAGKYFEKCCVDADACQLVLLPFSKTRWGSMCTVIERVLVLRPAIDHFTSTADKARDVPKAGPKRQMYRDFTISDCEYQVLEMLRKIMRPGVDIQQIFGAQDHPSIGLVMIELSKLIETWERMSESFTNFSIQPAIQAGINSIKKYYKNAIIAGVPVFALFLHPAFKDIWSMVHLGAETHEELLQAFTEEARWTRSLESRDCTFRRYRKIYATTSTTSSPATPTIDTDLPAMSASQMKMHKLKMERKRRAEELARSEAGDPELTELTDYFKLLEEEPVVPKGVQRHEFVSEWILTWWYKKQTIYPVLSKMARDIWGVQASSVPCKRMFSQAGLADTKRRQSMTPKHSGQLQRLQAHAKVVKEVATKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0R4</accession>
    <name>A0A1E3J0R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030656.1">
        <property type="nucleotide sequence ID" value="XM_019177503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0R4"/>
    <dbReference type="GeneID" id="30194629"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38062" checksum="676C463A69DFFA83" modified="2017-01-18" version="1">MSSTATTVQEQPSQAGVLKLRGHHQPGWDTVMLQELESKGYTVVKGAIPPARAAEYEDKAYQWLESFGKGFVRDDKETWRFANLPAFLQGGLFNRHGVHHEQFAWDIRAEPGLIEAFSKIWGTDELLVSFETDGVNISLPFVANEFPADAAAPWPHVDQSPRRREKHCIQGIANLAPNGPKDGGLMVLENSLPLYTEFFDTHPEVKPAEGWPTRDSWSYREEDIKWFESKGCRWKKVEAEPGDLILWDSRCVHYGAAATGEVPRVATYVCYRPAAGISPEMLQKKKECLADYSGTTHDPLDFFITGTNAHGPLTDDETQQPHEPAVLSERAKQLAGLVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0U1</accession>
    <name>A0A1E3J0U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030806.1">
        <property type="nucleotide sequence ID" value="XM_019177225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0U1"/>
    <dbReference type="GeneID" id="30194344"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="23721" checksum="7EA591E3C68FEAC3" modified="2017-01-18" version="1">MLETRISNTHLLCRAQTRLSILSIPTSSLSVADSTPTCSNDTLTSAQSSIDSGCSSDISDGGSSGTEVSALKGLLAHYTEFQAAACSTNTSTSDYCVTETLTTIQNAVGGNLTTSDVTSLLSGSNSSNSSSNSSIASVFTTGQLCTDCVNGMCYEALQANSSIAGNIIDKGLTSKCCSDFGTKAPDTASSASSSSASSANTSSSSSSAGSVATPFVGLLATAGIAGSVLGALVFGAASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2X5</accession>
    <name>A0A1E3J2X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031183.1">
        <property type="nucleotide sequence ID" value="XM_019176708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2X5"/>
    <dbReference type="GeneID" id="30193804"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="290" mass="32207" checksum="8A1CF96D4F44F590" modified="2017-01-18" version="1">MPPPPPAPPVFYSFSDSDVLVDSLANFVVKAQRDAVEKRGKFTIALSRGSLAANLRGLVGQENVQWDKWEVFFCDEAAVPLEDEDSNYHSNYLSFLSTVPIPPKQIHTIDVTQLDDLEELADQYEKQLVNHFAASNAARYPVFDLMLLGIGPDGETCSLFPGHEILTEKDAWVSYIDDAPRGPKRRITMTLPVLTHCYRAVFVATGKEKAEMLHTILDKPEAGLPCSRVRPASPGLVFWFADADAASATETPATTFRWIDNEKEAKEAVEGAKRKALRKQKEAEEAKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J349</accession>
    <name>A0A1E3J349_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031254.1">
        <property type="nucleotide sequence ID" value="XM_019176779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J349"/>
    <dbReference type="GeneID" id="30193877"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="720" mass="78181" checksum="3950FFE9A7BCBDA5" modified="2017-01-18" version="1">MNPSPAKRPRRTSTPSPEPRQGPSISPSRQLPPIQGTPTLPPPFGGSAGWSAGWRGGSRRSGAEESPSPKDEEPIAGPSTSGPNAGTSEQGSSMVFTRDTGGRAPRSMMACVRCRRQKMKCDGPSSVPCRGCRTAGQQCIFEPRSRPKSISVIPSRPFYPGRPGSPASFYPPGAQPAPPVTSRPMGQEYAFRPSSREQMGPPPGSTMGSVYSGMTSRRSPGPPSIASSANIPPSPYGYQTAPQAPPQVIHPPPFAVPIPQRPMSPTRTSTDARLHALERTLESTLRPLSWVPSALSTLQSSVNDLRAQVAPRRVFTVAEGTWDCYRTRVWPLTPWLVGLRDGAGLPGMVADMMGRRAEEVARAGQQGQGTSTIGLEGEARREVGRLIGEGREWAKEEVHGLCVLATWTNDRTYAALAVAEARSLGMHALRRTQDNWREWAYVVIMDTMCHVPDYLDPVTRTRLSGPWRERLGSMPTSDPAIRERDSRLLAWLVYAELLGEVFQYRETPATGNPLEMREERLVGPWSQFGQHWDAWASEFDVRNDPILSLYHMYAVLFTVTPVCFADDRSWEELATSPEGQQLLERGKDAAISLIQSICSTEVGRTLSYSFPLYRPLLALAVLHLISFAAALPAVPAVQTAQSSILHALRQAYETLNLHVPQREALPGPGAGVGLASGTGGAGQGATSGLLGEVAETGRLELGKRWLELSVGRDAWRRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3C9</accession>
    <name>A0A1E3J3C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031339.1">
        <property type="nucleotide sequence ID" value="XM_019176864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3C9"/>
    <dbReference type="GeneID" id="30193968"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="216" mass="23785" checksum="C75AC2C93371EA53" modified="2017-01-18" version="1">MAISPIDTSLSFSQPSLHPVLTIAYTLPPPTDSCTPAASFALTLPDALFVDPDELGGKWPIAAEPDEVGSDVWIWALEPSSVDIERPYSRNSAHHTLHIRLYPAANIKEQEVLEVPLHARYLPPSDQGERTLVFPGEDGSGLQAGWVCAESLSDNIKALELPLVHHQPVSLALPTGKHAHQEFVELVTPVVIWLGWAWIMWKLWGLTKRGTKVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3N6</accession>
    <name>A0A1E3J3N6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031255.1">
        <property type="nucleotide sequence ID" value="XM_019176780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3N6"/>
    <dbReference type="GeneID" id="30193878"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21492" checksum="E878346788E4E37F" modified="2017-01-18" version="1">MASTKPTQDQIEDAILASRFGDLDDLKAFVGEFGKEALAEGRDERGNSVLHMCCGNGHIDVLEYILPLVPSSLLTATNEAGSPPLHYAIMNNKTECVKKLVELPEEQGGGLPILKQKNANGRDAFLESCWSGEGKEEVSGWIEGYLYRVEGADDEDYEAQAKEVKMEEGDEVVQAEASAVDELAEKAEGLDVKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3Q9</accession>
    <name>A0A1E3J3Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031035.1">
        <property type="nucleotide sequence ID" value="XM_019177003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3Q9"/>
    <dbReference type="GeneID" id="30194113"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="185"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="768" mass="81687" checksum="C6532EC6BE4E6598" modified="2017-01-18" version="1">MAALTHQQPKMEQFTFTLGKLDAGMAILLGPNAHLLEFPSLLLPTPSPGMPPLGPGSILTITVARDLQAELSAQQAFADLQSSILSSFTVPPTAPTLRLRNVTQTNVCVEWDNINVGSAEFRGLEMLRNGQRWGRVGGDSGLGGKKEKTEWKTGGLQSGEEYTFQLVLKTTAGTYSSNLIRTRTHTMDNLTGLLVCFGPVQPPHLLEQLRYTLRQINARESPGVALDTTHFVCTSPIVGGDEHGRGGGPDVEYQEATRSNLPIVSPGWLLAVAEQRKLVPISQYHLPTLPSTAFQESNAPVFRRPSPLDLKRTSLSLQSPASSPTTDAEDVNRAPSPETVARMSMHASPSPTQGEFSPGIAEGKGRHDSLDSKKERQGSLDSNSRRTRSPKPEANGKLDRRVLSFKFPLATGSPVQSPTRTSPLSQSQTAFSVDQQIDTSTAPSSYSVHETETQAEASSAISSAETNVEDVKRISTPPIVVDHAMPEAYEEPVSAATLTEPEPQDRAEKASTIDEAVKEFQQVVEGPKASPAVEPEHDAKADAVNSEPSAASVPEVKKDDLITAKEEQVTEETPGVPELFTPAPVKDAPTPVETPPLPETPELAGETPALVEETPAPVKETLDNAENENIPTPIETPALPETPELVGETPGLVEETPAPVGEDELSNTENENIPTPAERASEPVATTTSADAPDTVLETTAVSGISTPTESTATLTKSQKKKQKKKAKAAAAVPTPIGSGTGAVNGAEVDAEVEAESKGEGMDEIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4S6</accession>
    <name>A0A1E3J4S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031555.1">
        <property type="nucleotide sequence ID" value="XM_019176627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4S6"/>
    <dbReference type="GeneID" id="30193722"/>
    <dbReference type="OrthoDB" id="2597009at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="645" mass="68986" checksum="81834EDAB765AE13" modified="2017-01-18" version="1">MDSNSYLEGVAATADQIMADCSSVVPIPSKPITTSGLQPRFAIPDLGSISNRANLSWLSPHLQQTVYQRIRVTLQSLRDNMLKTFRSTASGLLSQELLGGLNDREIESRLAQVFEEEYRRESDKLLNGVAHMVFRLEGQLVGSSTVISRKGSTFSTDALNTLESAYERCPVLSPAETNLVASAAGITSQQVRTWFQNKRNRGKKLGGGKPAKPSSGPRLVASLPKRVPRQPSCSYSASSEPLNLINDTPTRRPVRDLPRRAHSQRRTSFDPSFEITPEPSLVDGGSNSVFSPATLSPGSSCDSIASNGGFISPFSMHMAQQQGQDGGRQETQINICWDQGVLNVPFEALKSSEGVPNFEFVPPTPSQNNWGSFDAITPDALSFPGNFGMDDLSQMSYGGQFDDASLGLDSIEYILNEALSDPTAFGGLTLSGSPQFSESSALTPGSEAGASEASSTTFVSNGVRGGDGLDGDFFSVLDGMISAPSPDGEQACPIFSPQDRSVSSASSSSALSFTSSSTAPTSVSSSSALKQENQYQHNQYTKGLDLFVPVQHQQQPRQGSGNFDMGSVGNEIGHAWQGQGDFGAQPQQGQKQDQSSWGWTSGLLPFDSTPSPSDEHTPNPPFLNFPNSPNTPPFSQHTPTPSCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4U3</accession>
    <name>A0A1E3J4U3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex component CSL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031553.1">
        <property type="nucleotide sequence ID" value="XM_019176625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4U3"/>
    <dbReference type="GeneID" id="30193720"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000223">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="20557" checksum="A51D42139E0E0F0E" modified="2017-01-18" version="1">MSQAAILLPGQPLPSNLTAPPLPKAGRGCYEHNGQILASVVGRPRRVGAVVSVVGREEAVGIVDVDAIVSHPVHRLTPQQAHLTLTTLADRALPESSEEFTGVIRLTDIRLTERDKIKVGECFRLGDIVKAKILSLGDARSYYLTTAANELGVVYAKSEAGNPLVPVSYQEMEDEVTGKKEKRKVAKPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Q3</accession>
    <name>A0A1E3J6Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031780.1">
        <property type="nucleotide sequence ID" value="XM_019176370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Q3"/>
    <dbReference type="GeneID" id="30193462"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="401" mass="44742" checksum="A39169B5B1392696" modified="2017-01-18" version="1">MYAQQSTQTAPAEGSPEKKPVVILCIGMAGSGKTTFMQRLNSHLHSKNTPPYILNLDPAVSHMPYQANIDIRDTVDYKEVMKQYNLGPNGGILTALNLFTTKFDQVLGFVEKRATTVDHILVDTPGQIEIFTWSASGAIITDAIASSLPTVVAYIIDTPRTASPVTFMSNMLYACSILYKTKLPFILVFNKTDVQPHDFALEWMADFEKYQEALNDKARDEHGEGSYVNSLMGSMCLVLEEFYNNLRAVGVSAMTGEGMRDFFNAVEEARQEYETDYKPELDRLAAERAAQSEADKKTQLERLMKDMNVSDKPASTSNPFGPFPRSDREDAYYDEDVKEGGEVEDWDEEEQEAIRRQMEEEEEDADAMELGKLDVDEPEIGGLAGGAREGADRGVSWDAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6T0</accession>
    <name>A0A1E3J6T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031471.1">
        <property type="nucleotide sequence ID" value="XM_019176543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6T0"/>
    <dbReference type="GeneID" id="30193637"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="17981" checksum="6C30083FEF4BE925" modified="2017-01-18" version="1">MAPNLHNLLSSLRSPIFQTISNPTSARMGTKYLRKRLRGPSVASYYPELTNPFPKLSLLNKNIPSNPFAGWDGNPLPSAIKNRKGKVLLDEIQWKNAGSMLRASELVDSGFAEVERSKGTGWLENPVEQRRVARVARRRRFGKGPPKKGQGKRSQMKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8P9</accession>
    <name>A0A1E3J8P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031841.1">
        <property type="nucleotide sequence ID" value="XM_019175928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8P9"/>
    <dbReference type="GeneID" id="30193015"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76894" checksum="79AB0EFEBBB2932F" modified="2017-01-18" version="1">MGADQSKSSSSSTSEVDRRPPDYYELLEVDENADYEAIKKSYRKLALVNHPDKNPDRIEEATKFFADLQQAYEVSECERAFYDSHRNAPVAATDDDIFEYIRAGDAATNDPRSKLNRRPAGDPGIQLEQLMAFFDPKLTRKLDDSTEGFYSVYRTLFGLLASDERLHSDTPHRMMYPSFGQSSTTYSPPHGLTRAQKDSQIWARDFYAVWGEFVTEKRFEWINKWDADKGDDRMVRRAMEKENKKAREDIRKDYNDTIRQLVSFIQHRDPRFKLHQAKLAQTKSMKSSSSKVATPSTKPAVQAEAAHRREQERLRQAAAYEEQDWQKMSGNNSDNGDEVDEDAEEEQVGDGTGVRIDDGNGSEIFECVACSKTFASEASWENHERSKRHKQAVWRLKKEMRAEAKAMGMEIGEAEEYDEPDATEPAFLAKDSSLATPPEDVGGLQEEYDETTQASKKPKKKGGRTAPQSGPPESKPDIGTTSPLLKQRPLCDELDATDRDTKTDKSAASGPSKRDKRRAREARKKADEEERLAAAKAARKATKHSLTTSRDEFASARSSGLSGQAANDAESFVMPKQKGKPRSKAKGDKDGVERDVSASEDQLKAVVADIQEKRDKMIEKWDSNWEELGTKLNKLLGDNNQARATRVLCLGLGKPYTDRTARIQLALLLGLLTALQVSSSYVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J925</accession>
    <name>A0A1E3J925_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031956.1">
        <property type="nucleotide sequence ID" value="XM_019176043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J925"/>
    <dbReference type="GeneID" id="30193130"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="57"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="577" mass="63343" checksum="DC29D41B66195BED" modified="2017-01-18" version="1">MSTLYTARETPSPIKIEPSSVTSSARKRKRSEIDQKDSPGVESPSRGWEAIAGGLGRDGWTYHLEIVQEPLRARACGFGNKASRKSLDRRPLTPPPIIRLWIRTATGEVVDPNVINPTTLILQMDLVSVDGQEERNVVKHPIGSASTATISKPVGSSAAVSQPWMGTSDMPGVITGSPRQSLSEHSGYRQRSWAEPYASDLGFPRWAEPTQAYAPYPYAPPHSGEWSPNPRSWQAANEGRRPRQLPSPRPATAQTHEQAPPLLPSASHRHSAGQTLPPLSYITESPRGSTHNASLPSIYSQYASYSRPTSSRSSWDRAHTSQSPGEFASAPADYTMARPSTASSISSFYHPDAAYRDRAHTGPWPDDTRPPSMSYTSDHRPSASSLDDSIVSPRSVSRHRFSSSSEYSSYSPQAYSHTFDPVRGIYPSGSFSADHYLTQPNSISTLVLVGKRHTPCNKLQDEHGQLGLFFFATDLGVRTEGKFRLRMKVMDLALFSPVPIQGEHIPILADTFSEPIEVFSAKRFPGVIPTTDLTRVFASQGIKLAVRENHKKGGRKKKGKGDDGDGDDDNEDEEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9F3</accession>
    <name>A0A1E3J9F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032092.1">
        <property type="nucleotide sequence ID" value="XM_019176179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9F3"/>
    <dbReference type="GeneID" id="30193270"/>
    <dbReference type="OrthoDB" id="2571236at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN97490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="344" mass="38036" checksum="01A158A5611F6AB8" modified="2017-01-18" version="1">MLSLAQVDGKLVLLGLPPSLSQALGMISPAPRAASVFSDPLLGGEQGVQMLHYLRKSEVDKPEEEVVERMCRTWDVGSDAVRLDEKVREYDLEVEQYIEAAQTNPTFLVENYHRAVKSYDLMVNIRMVEAVVNIEKTLQLVAKGKSNGTVIKRWKSKVDSRDIQGLADSVEEASAHKAKGNTAGKASKYDAAIKHYLEGLVALWPWTANSSMSYGTATTTGLAQMEQALLGNIAIIALKTQSKTGPKRAAWDEIAKIACELVLMMRYIPNGTIMKAAESGYDSPADFVYAENLLGLAQIETRTKRVGRMPNGAWQELVNVVKDKPSDHWAHRQCYTSHDCCDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCA4</accession>
    <name>A0A1E3JCA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032365.1">
        <property type="nucleotide sequence ID" value="XM_019175875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCA4"/>
    <dbReference type="GeneID" id="30192961"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="706" mass="75004" checksum="6B7E6C0F05963261" modified="2017-01-18" version="1">MASISAPTSIATFPQPHASTSKLPHVALSPVVGDARSAVAAVQGDGVWTYDLSTLRAATSFTVPPATTFTTSPISYWTTKTKAKAPAANDGGMDVDEPEDGTLDLETEILKERVTAVGVGKEIWVWRGEDGEKEVVRIKSQVNALHYIPSSSTPILALTSFSQFYLIDPSTTTAHSIMPSSKGELLTSRIIQGETTRLVLVSVDGKVEVSKVWVEDKRVERLLEGKVGEGELTGGDISEDGTISVLDKKGNLYSTSIRTLSSTSVPIHLNHPSVAPVVCSLPSASLPLLLVPTSHPNPSLLLTVPSSTLPSIISTSPLSSSTSSGTISALGVLSSKHGVYTIGVVLSHKHGESDASVGRSVLYTCEIALPAQGIGMGLLLGTKSKTEEYLSVGGADKKEKKSEEEKKEDRLVEAVNKALRAKDVAGATKAWRNYAASETVFSSKLVKAIVSTIFGAALNGEGRPTGVYAVEVARDLVSKGLVNDSMWKESVVVDGLLPLGDWDTITAALSSIKTISSSALVALIRSSITSTTPSTSALLKSILSLPPPGPTYRVDLHQGLTVEEATLVLEVYNTWAAEHVEALSYGLTGWESASPIEGSDLPSLTSLVTHTSSLLDAHLPSFLSHLPSHETLSQLQSSLDPLLAAQNEYRQLRGPVEALLTLSRREAKKSEERAQKKGRKGKKAGKEEGKLPEEIVGKWKVEDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEK9</accession>
    <name>A0A1E3JEK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03782</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032398.1">
        <property type="nucleotide sequence ID" value="XM_019175908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEK9"/>
    <dbReference type="GeneID" id="30192995"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="50"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="350"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN98536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="50647" checksum="5C0324BCAEA92364" modified="2017-01-18" version="1">MSGIHLPALGRSTRLSRTAFRPNQSVLYAMATRSFASTPAGIERIKVKNPVVEIDGDEMTRIIWKKIREELILPYVDVKLHYFDLGMESRDATNDQITIDSAEAIKKYSVGVKCATITPDEARVKEFKLKEMWRSPNGTIRNILGGTVFREPIILDKIPKPVPGWTKPIVIGRHAFGDQYRSTDFLAPGPGKLTLTYTPADGGAPTEMNVYEFKGKGVAMAMYNTEESIFGFAHASFKMALSKKMPLFMSTKNTILKKYDGRFKDIFQEVYESTYAGEFEKLGIYYEHRLIDDMVAQAVKSSGGFVWACKNYDGDVMSDILAQGFGSLGMMTSELITPDGKTMEAEAAHGTVTRHYRQYQAGQETSTNPVASIFAWTRGLAFRAKLDETPELAVFAKALEEACVEVIDKDSIMTKDLALAMKGKDMTRDDWVTTDVYMAKVNEKLIAKLKASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JG35</accession>
    <name>A0A1E3JG35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032682.1">
        <property type="nucleotide sequence ID" value="XM_019175579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JG35"/>
    <dbReference type="GeneID" id="30192662"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="33"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="24839" checksum="8808D6B64F258483" modified="2017-01-18" version="1">MSKTGAILFVFTSADKLLNGAATGWYLPEAAHPYYALAPHFRIDSVSPNGGEAPIDGNSVKMFTDEESQKFLNDSKAQELYKKTKKVADVNAADYDAIFVIGGHGPLIDLAKSTEFAKLVENFYTSAKPVAAVCHGPGALVLAKNPATSKSIISGVNVTGFSNAEEAQTPYNDFVNILPFSLEDKLQELGGKYSKAEQDWGVKVIWDQGVLTGQNPASAGPLGEKLREILLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIR0</accession>
    <name>A0A1E3JIR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032907.1">
        <property type="nucleotide sequence ID" value="XM_019175175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIR0"/>
    <dbReference type="GeneID" id="30192254"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="51410" checksum="72889D79A838277E" modified="2017-01-18" version="1">MYGNNYAQPQQQWGQAPYQGYQPGYQNGPPPVNHGQHPSQGGQGGQWGAPPQQQQYGGPPQGQFNGGGYGGPPQQQQWNGGNQGFNSPAPGMGGGYGSAPPQGQYGAPSQPPQQFGAPSPYGGAPQLQGGFTPGQLQGPIYYLGAPIPAPPPAVPTSTLSGYNAQFDAERIRKATKGFGTDEKTIIDTLAPLDAFQMEVLSRTYEQTVGRPLKTTLNKELSGWLEYVLVLISLGPLAGDVHLLHRACKGAGTHEDLLNEILLGRSNQEMFLLKELYQRTHHKDLAQVVRGELSMKTESRLFNMALSGQRDESPHLDHNLVQQDVQTLYRAGPGKIGTDEIAICGILCSRSPAHLRAVAQAFPMAHRTELSKMIKSEFSGHMQDALYYIARGAEMDGDGIVRDVELLQAAMAGMGTKDERLCYRLARAHWNRPRFNSIKNQYQGSYNKSLRRAVEGETTGKYEKALVAIIEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW8</accession>
    <name>A0A1E3JIW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032967.1">
        <property type="nucleotide sequence ID" value="XM_019175235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW8"/>
    <dbReference type="GeneID" id="30192315"/>
    <dbReference type="OrthoDB" id="10600318at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="74" mass="7584" checksum="044B22BF94A750F0" modified="2017-01-18" version="1">MAPIPAPSRPSPDNLAFPFLTFFSNVFGLATPSVPAIKSDTSPTPSADPAAPTTSHDRSPAPSAAKYVDTNASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIX7</accession>
    <name>A0A1E3JIX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032965.1">
        <property type="nucleotide sequence ID" value="XM_019175233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIX7"/>
    <dbReference type="GeneID" id="30192313"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="791"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126535" checksum="BBF1E60234537CFB" modified="2017-01-18" version="1">MVKNNQPLQIRLTEPVIFLKGPSTGLDFRGRPQAVRQDGQPAMVRGLLTLRLSKPTRIRSIAIKLEGKARTEWPEGIGAKRMETSEEHVILIDQATFFNAYQHDSSRSRSTRRALSLGPGVNVGRDEDDIDDDVDLQEVPRDDDADDWVNIGRGRQGRGRNTIRSSSAMPGTHDSSSWHRDGFFRRPSFDNSARSSMLDMPGLSMQDRGPSPAYTPTASPTRIASALPGHVARPSSLRQSVSPHLAPSRGPALSPIASAAPSQNNSDRGDSAEAEHRRPVYTSTLTSEDVREETDGEPRTPTAPPQDDSALDEGVDESLDLPRPILESRANSSSYAHGEVRFSVPAGEAAGGEGLPMTDETAALNTPAGTPPVSGGGRAASVRTFNSTHSASSTSLSSGQDHSGGENHPVSSAIQPTSGPNTPAPSAPPSIRQVSTDGAGRPRSAASHPGSILSSRQPSDQNLHNLGHRASGESLRGGERTRTARAGSTSTIVENTASTFSSAGSSRPPSRNRTTRAASGTPAITTASNLAHLAPSAASTEGVELSDDGRGRKNHKFSLAATLRGLSRDVKERVSHGGRHPSKSRSRMDNSSRAELHETSDSPNSSTFSNIAMPMSRANSSTGPGPIDHAHGSRHGSLVNDDFVPTYRRGGAGSTRRSRSRERDSSKVRGRDDERSRSRARGRHMGMKVLTDKLGLGETEDQGDDVHNWKEFRKGKSHCTYNYPISFPIPVNAPPTIHAEFGSVMYRLKASVVRVGALTPNLTEDTEIMMIATPQEDDLEETENVIVERQWEEQMRYQITLGGKAFPIAGTIPISIRLMPLLKCKIHRLTVALEEKTDYHAQERKVARHETPKRFVLLFIKQADAKERTEPLLPIISDDPTAAERSPLAEMARQAAMSDPPADLFDLERDPEDAMYASLMEPTGPWHLEKDLQLPDCVSKIKFTTKHDQTNITVAHWFKVTIRVERGDDEALDSKGRRKQFDIIIETPIKILDCRVNPSYNSLPTYSVTQRNFVSTPGICSVHNTKSAPPVPIGMSRHSSTNNAGEATVAGTPPTTLSSLPEEQPHGHLLPHISSHRRTEVEPVGNAPTVPGVDEEDTLLERNIVYDRLMSGQVTETGEVPPTYGEAMAEAVGDRSVSRVRESEVSANGRGVSSSRGSRSRSRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLR6</accession>
    <name>A0A1E3JLR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ enzyme repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033056.1">
        <property type="nucleotide sequence ID" value="XM_019174677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLR6"/>
    <dbReference type="GeneID" id="30191743"/>
    <dbReference type="OrthoDB" id="202289at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="41410" checksum="C2227FC2B5A911D7" modified="2017-01-18" version="1">MDQNITRRRGVGTRAVDDSVALDGYTVIAPLTSKNVYIVDNAGQVVHKWDLPYRVGRYARILPNGNLIVGMKDPEAAAPFPFFNKYGGGVYMELDPAGNVVNELRDPLGHHDCFYEGDGHFFYAGLEALTPEQQAALPGGVEGTEAPDGNTYADTIREVKNGKLVWEWRVSEHLDPKIFPLQSHYPREHWPLINSVFPLKDGNILASLRSVSAVIIIEKETGKIIWHLDSTVVAQQHNANELPNGNILIFDNGAFRHRESFQYSRAIEVDRTTKSIVWQWHAPTKETFYTPFMGSAQRLPNGNTVLCESAFGRVVEVTSEGKQVWEYVCPFFAVYPEKEAAGFYPTESNALFRAYKYSREQIPWLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMJ5</accession>
    <name>A0A1E3JMJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033326.1">
        <property type="nucleotide sequence ID" value="XM_019174947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMJ5"/>
    <dbReference type="GeneID" id="30192018"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84228" checksum="9EBEA832A3703108" modified="2017-01-18" version="1">MAGIYCGHLLEFPTVRIDSFGAPPPGTALPLVPVAGGGAVGCCSPPNAQLFLLSHTHADHLLGLHADWTGTIITSQDSKGMLLSLVPEREREWLYRNIRHGPRRRFAGLKPRVAASPVMVDRIVSPVAKTRTELTDMLWKTLPYGVPKEYIIAYDNGSPVYVTVTLLDANHCPGSAMFLITSPTIAVLHTGDVRADSRFIEYLKRHPALQQFLAPSSTYRHAKDGVGGGRRVLDRIYLDTAAMLGTGDMPDREPVLQEMVEIMARYPQDTIFFLNTWCFGWEQVIKEVARFFNDKVHVDSYKSDIYKSITTDPFLSRCTTQDHTATRFHACERFVKCPACRRFNEEGAAVYNLDKRIVHVNMVEVKMAEWDTRRGEFMRVLDRAAMGKGHWPYNIDIPIPRHSSLPELQALVKLFKPLNLTPNTVASYARGLDYYLLPDLFSECIAPGAYERIVIERTHYLGQKYGEWYVKGLDLMRETMGLGLVPDLEAVEREDHHYARQDYIQESEDVARQIQPPRPRSRKEISIDQVSRAGGLPSLAPDDIYPAARAIMGLDPEEDGQKKKAKLVMTDPEYETDHESCGMRSSPGPAQDDLEVKEEVGEDLFWGVKEEERTPKAVKVEAEPGLEIKERTPSPRLPIKKESPATPHGRVPIVKSDPLSPPSISTPQPSNAPPAGPSIMPELESARDTPKVVRVKEEPCERLSEPPFAPSRKRKKARRSLTAEEKEQIKRRLAEGGGEGLGRNIVKKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPH6</accession>
    <name>A0A1E3JPH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033064.1">
        <property type="nucleotide sequence ID" value="XM_019174685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPH6"/>
    <dbReference type="GeneID" id="30191751"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12015" checksum="B303D2DA0B8C1056" modified="2017-01-18" version="1">MNWLDPPAEPPNEDPPQNPLQPSISNLNYWAARLTPLHDPAPGYSPPSHSEGGEGKEGKEVVFVTCNRVGKEAGTKFIGTSSVLSMSSDPSRIELIDCCNISEERVLLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JQ39</accession>
    <name>A0A1E3JQ39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033284.1">
        <property type="nucleotide sequence ID" value="XM_019174905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JQ39"/>
    <dbReference type="GeneID" id="30191976"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="572" mass="62621" checksum="5FC84F2B6271A468" modified="2017-01-18" version="1">MVSPIYIPDSPLAPLSPRSPHFFPSKSPLPSPFVFKTPVKSPKPSPRSPVPISIGTLWCLLPFLVTALHVLLVPHTKVEETHGLHAVHDLLKYGVTQIDKYDHVTYPGPVAKSMIPSIILLAATYPLSLLTGIDEGPHLQILIRLVQSAMFSAAVVHLSRSIGMYYKSPLTSRLFLLFSMTQFHVPFYAGRTLPNFMALPFVLWGCSYVIRPQQSARGVMQGICLATLTATISRLELAPLAIALAGISVLQGRVSFTRALLSGAAGGFLGLALTNSVDTYFFAPISHLYPYYQWPELSAAVFNIVQGKSADWGVMPGWYYLAALVKLGMGAGPFWGCGVYMGLRGERVERRMVQLVLGCTIAFVGCLSLVGHKEWRFIIYSIPLLNILAARAAAFLWHAYIPSRYLKLKSQKIQAHLCKTIIILTILANVFLTIIFTSISRLNYPGATVGKILVELAHQNHSPTEVHKVYLSASALHSGATLLTLPSSSVSTSLGLQLDHPESAYERCSSPWGNGPQELWDGGYMWVVGDEWKEFERSGGWEVVGEIEGFAGVGRGGIVSGRRLAVLQRTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR29</accession>
    <name>A0A1E3JR29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033382.1">
        <property type="nucleotide sequence ID" value="XM_019174330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR29"/>
    <dbReference type="GeneID" id="30191389"/>
    <dbReference type="OrthoDB" id="10505847at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="169" mass="18883" checksum="247FE6B0EBD9DA7E" modified="2017-01-18" version="1">MSTSLPQLRIWDHIPNPFNSSPSSPFSDAEDDGQDSISKIKLLDLNDGSMHHPFEGDIMAATREEESLFASRMANETARSDDAPMGVLDWLDIEAGEEAQDEVVTGGWSWAMPRPMRPTASRFFVQLPYHLRLRHTKDFDHTMAVPPPRQVAIVPGRNVWLPLVDSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRI5</accession>
    <name>A0A1E3JRI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033525.1">
        <property type="nucleotide sequence ID" value="XM_019174473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRI5"/>
    <dbReference type="GeneID" id="30191534"/>
    <dbReference type="OrthoDB" id="2570873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="294" mass="32994" checksum="7A564E625DE0ECEF" modified="2017-01-18" version="1">MPALASLGLSLPRRSLSLRHFPQLAPRASSTTAKPTPRAVTRGPVPRRPVFKDSSKPTVSNWPWRQVKADTPHGFELERTLFARPPDMNPRMLSLITCVMGLIIMSFVIMPPKKKRDPTPEEIAELEAKAAESNIFFQYGVKIGSYIFPSANAVLGTGFAATLIVAHLFARRIITRLTQVQSAPNGPISLRITTVGHQVLDGTMFAMKPRKVETKDCSVYFLDHENATTVRLRVLQPNGLPYRWTLDRYAYSLDFRKLKDDFKAEGQEIVLSVPRLDYIFGKVGQGTPRYSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW95</accession>
    <name>A0A1E3JW95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033784.1">
        <property type="nucleotide sequence ID" value="XM_019173977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW95"/>
    <dbReference type="GeneID" id="30191030"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="477"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="814" mass="89070" checksum="0457E37514176431" modified="2017-01-18" version="1">MGRKNKSNRKTNASSGSADANNSSAATLRDEPPTGRQHNNPLSTVEESPIPFRSSLPSSPTNSQLPTFNFQHFASLVEEDGQLSPTAMDPSRRSSASSLSSAYPLPPHRRRATTSSLEDAPVLQRRVSAHSLDDDDEPVIRRRPSASSLDDPAPSFGLAIPQRPSLTSTPSEQPLLAAETPRDEENFEVSSPGAAQQLDHREDSTPKTSFFNNHSSSAPSAAPKIRINDMPNSPPVHDDSRVPTPPVIASLTASPFAHGVRRPHHLQNQPPTPTTPISPTNMTHGVHTRQSFASVGSPSSYPPRNLAGVGTGMDSSSALAGPGPSTVAAATPNAPTHTAGLPRSVSTVTINAPGVSARTTGFDLPNSTSRNTIAERRAMRMKQTMSTSTSRRSRINDMGTTANKPVKGVLNRKPFQSTRLKGEIYKPWLEKKDPALRWARWITITSIFIGFAIAGIICWDGYRSVPKLGTVCSILNEEWSNGIDSSIWQHEVRTDGYGPGSFSWTTASSNNSYVEDGILYIVPTLTSDTIGIDAVTSGYTLNLTADGTCTSSNVSQCVAVSNSSQLTVINPVQTARLITKNTVSLKYGKVEVKAKFPTGDWLWPRVMLLPVNETYGAWPRSGQIDIMSGRGNNASYAGRGVDYAQSDLHWGPTTALDRLYLTWGYREQRRTYYSDKYHTFGFEWNENYLWTYIDSRVSQVVSLRFNKESFWTRGKFPSTYTNNSDVVRLTNPWSSSENNNAPFDQKFYLAIDLAVGSMDGWFPDSEGGKPWTDDSASAMSDFWAARNKWNGTSWSSDPKTRGFAVDTVKVWEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWW1</accession>
    <name>A0A1E3JWW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arf/Sar family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034000.1">
        <property type="nucleotide sequence ID" value="XM_019174193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWW1"/>
    <dbReference type="GeneID" id="30191251"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="184" mass="19810" checksum="7C697D1FF94CE89D" modified="2017-01-18" version="1">MGVTFSSLWSQLFAKKETKVLILGLDNAGKSTILYRITMGSVVASAPTVGSNHEIYDYKGVRFGLIDIGGQTSLRGSWSQYFQGAEAVILVIDSSDSARLGVVKQELMKIVADESLSTALLLVLANKQDLPVAQGRLTPAQVSEALGLTDLREREWQIMGCSALTGLGLFEGMDWLVGKLAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX17</accession>
    <name>A0A1E3JX17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034069.1">
        <property type="nucleotide sequence ID" value="XM_019174262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX17"/>
    <dbReference type="GeneID" id="30191320"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000017">
        <property type="entry name" value="Oxysterol-binding protein homolog C2F12.05c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="285"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132176" checksum="E3F82A0B01313A5F" modified="2017-01-18" version="1">MSGQHIAPRQPSPEKQPRVSPNPSVHSNLSALSTNAPPSALYNFRLLAALRSEDPAQIQPFLNQIKAGPNGEDLDKAGQLLGMAVRVANVPIVSLILASVPSPNLPVAPNSSETSLHVASELGRVDIVRLLLQDPRIDDTIKDDRSRTALECASTADVASAIEESRAQIQAHYANLLSLYIASPLNSAEEGAVLGAFLESHRIGAVNLSALDERTGTSLLHEAARRRDLKLVELAVKGGADVFVRDKRNRRVLDGEKSPDERIKLFLRQFNNQDSLIEARSDGRPPDLRGFLSKWVNYRQGWRTRWFVLENGILSYYRNRDDEAIACRGSIAMAVATLHASSDGTKFDLSSQVSSAVPKFMVKSVHRAEIARWVQTLKLNIEYYQHGAGKDASRPSMSPSVAPRRSGSLQRPDRRAASVVSQLPSGDTFLSPTLQTAPGLSGVNPLSKSASTSSRVTGTHASSIRYDNDNASERSDDEDDQQSADTIPHEATFDLGLINIKEQLEMTEQLVDSIVVSPNPPSPGNASPNTTTASRQAAVKDAIRESLSTIQILMKKLSSMSADRERFFTSRIQREVQARQLWEENMLTIATQQAEYEKELNAAAKDNEKKRRALRQAKGVLAGLSAGGSLPGTPVGVEVGGQGILDSAPVTGVSDSYAPPKTAPAPKGALASPPALVNQPSISNIQDVQNAHAAIVAADSDDEEDDADEFFDAIEQNQLPNLRLHQSIAHPERPGTPSASRAGSLDVGVKESEAVTKGTVKEYLARQSLEPYLHVRSKLPIDDDKRPSVSLWSILKSSVGKDLTKISFPVSFNECTSMLQRMAEDMEYDACLTVAASEKDSLRRIAFVGAFAMSNYSSTIGRIAKPFNPLLSQSFEYAIPNRYRYVSEQVSHHPPISACYSEAPTWKYYGEVDAQNKFQGRSFEIRPTGVAHAELIIPKSQVVPGLDYPDAGPEYGEGYVSEHYSWKKVTTNVSNFIMGNPIIDHYGDLVVTNHRTGETCTLTFKPRGWRGKDAFEIQGKVQDADGAVRWDIAGRWDTQLIAREHGVESVPLAVDATVSPTQKEYILLWRNSEKPKAPFNLTPYAITLNDIPQGLEKYVAPTDCRMRTDQRAFENAEYDRAQGLKTLNEEKQRNTRNLRTQGKLPPHEPQWFVSTIDDDTQERLWEPKRATDGEVAFWHEREKKNWESLGVESIFANDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXB3</accession>
    <name>A0A1E3JXB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034098.1">
        <property type="nucleotide sequence ID" value="XM_019174291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXB3"/>
    <dbReference type="GeneID" id="30191349"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="327" mass="36203" checksum="48D47D130DE971FF" modified="2017-01-18" version="1">MPNVQFKKGPSRRPAQSRRRSPTPPAEAEPSSSVVRTQTKSIANPLVQGTKRRRDVQAGDNVADDENGLDEFGYRADEGLTKRADELVTRANDWDLENDPVPEKKVRLNEDGDIDDGIYRGASNYLPTINKTRETLDKKMKSGPIKATSHVRTITLMDYQPDVCKDYKETGFCGYGDSCKFMHDRGDYLAGWQLDKMAEDGGGGGRAQVEEEDEDEEVPFACLICRKPFTVPVVTRCGHYFCMAQVLPPSFSPKCATKRFQKSPKCYACGAATQGIFNTAEKIIAKIEARNKVRQEERDERKGQENDGGGIIFGGGDAASDASDNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXG1</accession>
    <name>A0A1E3JXG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034101.1">
        <property type="nucleotide sequence ID" value="XM_019174294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXG1"/>
    <dbReference type="GeneID" id="30191352"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="159"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="399" mass="44494" checksum="85CB03DAA0AAD206" modified="2017-01-18" version="1">MVALESLLLTDTSRAFRRAAPHPLIFRLISWAIDTVVAVSGIIRIPLLAIAYVLSPTPFPGWSFNRLVQVRTERLRGTLLSWVLPTILFDERQKEEWTFYTEEEREGRVKIDALDIPPVDARWTGGFASLGEVKAETRPAFLICPLKGERAHRTDGRIILHLHGGGYIRGHPLWTPFPYNIARATGLDCLSICYRKCLSPSSSFPAPLFDALSAYFHLTQTLHYPPSSIILLGESAGGHLSLLLSQDLHQLGLPQPGSIALSSPWSDWSPSYPSYAENEPYDCVCMPRLRGAVLSATRYFERKALKSPWFSPSKASPGHWTYLQEEGVDVYLQYGGREAMRDEVAVLGESMKRDGVRVRVREDVNGVHTSALTDGGARKTFEKDLVEMLSDGNGAEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYV9</accession>
    <name>A0A1E3JYV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034158.1">
        <property type="nucleotide sequence ID" value="XM_019173453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYV9"/>
    <dbReference type="GeneID" id="30190500"/>
    <dbReference type="OrthoDB" id="10327621at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="42164" checksum="9FAF5AD612912290" modified="2017-01-18" version="1">MPQEPYKPCACANANISLPIYGITSLSPLPAEIRNLVHSFLIAAPCKAHALIFTRLSRDHYTTIIHRLYLQIVATDQAVDAGLYKSFSNVDNQSHQSDEHRTLPSKKELLDGCESLVFTSLYAWTQTTGMLKRRFIPMHHEDMFRSLNHVAFAPGFVEEICRREAPPFNRCITPTALWYISDACIQLPESFSEDLAMNLGKVSSYLLEFGIGICGTTETVLHFHNCQPTKLAMANERVTSFVYDVMSIDIPPTRIENAVNIAARQIDEIVEYCVKSVTDWDEMNTQFSIYGPSVPFGKEIVFTNFGTVITPAGLVFVISPSIAQSVIERVESEVRRRVRLFLESELPAGCGLEAHFHVRGYDECRFCPLRRSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ22</accession>
    <name>A0A1E3JZ22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033797.1">
        <property type="nucleotide sequence ID" value="XM_019173990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ22"/>
    <dbReference type="GeneID" id="30191043"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31031" checksum="3DDA66E50CF35638" modified="2017-01-18" version="1">MSFKIDNIFNVKDKIVLVTGGGTGLGKAITAGFIQNGAKVYITGRRQEVLEAAAQEIGGPIVAIKGDVSTKEGCKAIADAFGTKESKLDVLINCAGVMRGWKTQVKSHDNADEVENLLWEGHDDDDFNYSNSININGVYFITAALVPYLRKSDHDPSVVVIASIAGLANQRAMGTVSYGVSKAGAIHLGKLLAGRLHPMKIRVNTICPGIFPSEMTGKNDSGEGHEYNLADGAGKAAKRSTVGRAGRPEEIVGPVLLLSSAAGGYFDGALLTVDGGRLMGAGINDGLRLPEDTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG4</accession>
    <name>A0A1E3JZG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase assembly protein subunit 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034340.1">
        <property type="nucleotide sequence ID" value="XM_019173635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG4"/>
    <dbReference type="GeneID" id="30190685"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="85" mass="8956" checksum="381730AA42559DAC" modified="2017-01-18" version="1">MLTQLHPISSESPAQAAAQSTPVSPVAQEVNPLNPKGLKPCCACPETKSARDDCFIKSAPGEGDIACKDLIEAHKACMRGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZU7</accession>
    <name>A0A1E3JZU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034393.1">
        <property type="nucleotide sequence ID" value="XM_019173688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZU7"/>
    <dbReference type="GeneID" id="30190738"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="42555" checksum="4273279E04DEBACB" modified="2017-01-18" version="1">MAPKTAPISSAARRSKRVVDSESASSTGEPSASPPPAPAPRRARAPPAKAPARATRGAGAEKRVTYAEHSEDDDDGVVEEESEEDELEEEDESMEVDEPAPVNPLRIKLTVKRQAPAASGPSGTRIKLPSRSLSPQKKAASKKRKSREETLDMEEQGDGEGEQDDLEEDQLLDEEGFEDDERRHPSSSPSKMTARQRAKGNSDLQDHLLVLEEGRFTLACTLCTDDTPARPTRALQLTEQEKIERKEEASRRRRRQIEQRLQDEQDETINRLLRAQTSRSRAKIDDDNDPSTGNPSPSRRIQAPPEGMVRWTSKMGKEGAVVMSVAVPTGQERWLDMGAPSVEPKKDERMCNAPGCGEKRKYRSLKVFEKGGCSMAHLETVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2R6</accession>
    <name>A0A1E3K2R6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD hydrolase, family IA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034802.1">
        <property type="nucleotide sequence ID" value="XM_019173076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2R6"/>
    <dbReference type="GeneID" id="30190117"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25231" checksum="312CAA96BA6B3104" modified="2017-01-18" version="1">MDGLLNAILGRYGYEMTWAIKSGAMGKPQRVAAEYILSHFPGIEEHLSVDQFIDEGLQRREELFKKVEPMRGATELVQGLHAAGVPIALATGSTMQNFIHKTTHLPHIFSLFPPSSILTADSAHVKRGKPNPDIFLAAAESLGRDVGPAEGEVSEKQKEERRKGIVFEDGTPGVLAGVAAGMNVIWVPDPELLALNPEEKFGASEVLLHLEEWDPIKWGLPPLPGFNGTPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3S8</accession>
    <name>A0A1E3K3S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034664.1">
        <property type="nucleotide sequence ID" value="XM_019172938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3S8"/>
    <dbReference type="GeneID" id="30189979"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="12">
        <location>
            <begin position="237"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="41412" checksum="000B418EEF98D7AD" modified="2017-01-18" version="1">MSPAQVTQQLDDLDIASTLTTPAVTRPSSPAPPSLPRSPLPTGKHKIAVIGSGSWGTALAKIAAENAWKHKDDFHSEVRMWVREKIVDGKPLTQVINRTHLNSRYLPDVPLPRNLVAVPHLKDVVKDATLIVFVVPHQFLHTVLNELSRPGILTPGAKAVSAIKGVEVNGTDIQTFASLISAKVGLPCSALSGANIALEVALGQFCETTIGCPTHEEVLLWHAVFNAPTFRVAAVEDVSGVSLAGALKNIVALAAGIVDGLGYGGNTKAAIMRIGLKEMTEFCLEFFEGSKRETFSNESAGVADLTVTCYSGRNRKCAEEFAKTGAPFDYIEKKLLNGQKLQGTATAEEVNAFLVARKRAHAYPLFEKVYKIAFEGMPPKNLVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Q6</accession>
    <name>A0A1E3K5Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035365.1">
        <property type="nucleotide sequence ID" value="XM_019172423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Q6"/>
    <dbReference type="GeneID" id="30189453"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30396" checksum="D80B3CA5AD6D8281" modified="2017-01-18" version="1">MASYKSFLSNELFSIKGKVAIVTGGGTGIGKGIAAALTLNGAKATAKELSDAAAEAQTGGECIPIEGDVATKQGVTEVYDKISAKTDKLDYLVNNAGFSANWRKMASDLNDPKELAEQLWSIEDCDFANMTAIHTAGPYFMAIKFLPLFQKSENPAITNITSLAAHFLNRAVCEFSYAQSKAAETHLTRLMAAGLLPYKVRVNAVCPGLYRSQLTTGSTDPDAPFWPPQINAMNNGGIPAGREGKWEEIAGAVLMLASPAGQYFNQAELVIDGGWRMCTSALDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5U5</accession>
    <name>A0A1E3K5U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035404.1">
        <property type="nucleotide sequence ID" value="XM_019172462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5U5"/>
    <dbReference type="GeneID" id="30189492"/>
    <dbReference type="OrthoDB" id="2563847at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19592" checksum="D64DAD68457FA94D" modified="2017-01-18" version="1">MSSPAQSAEHDPLDLESLDADSLFSALTGVEKAIPEILLQIKPILTQLSSPTEGSGGDDESRGMEARQGVEKYIDLLDKIQFVLRQTVYYLRETKSNPNTLCPPPANNIPTPFASSIPSLTPASPSSPSGTRGDIVDDRQEATKVAELGLYASRIEARVLSDMGKAVRALVEEAVGQGRQVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K676</accession>
    <name>A0A1E3K676_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035372.1">
        <property type="nucleotide sequence ID" value="XM_019172430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K676"/>
    <dbReference type="GeneID" id="30189460"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="598" mass="66130" checksum="FC9544566F2E948A" modified="2017-01-18" version="1">MPAPAAAPAPNGKDVSNGSVAAPVKTSGVKSRGALKRLKAKAKAGVPKKEERASVPVTEPESEAESTTSTIDNSILEIDPNDPNFSAFSSVFAHFQEEATEGDEAAQGPQKGEIYYSDEEDDDAEAKERAVRKAAEQEGMTRRQKRQAAKLTVAELKQLVDRPEVVDWFDCDARDPRLLVNLKSYRNTVPVPQHWNAKRDYLAGKRGMEKPPYLLPPWIADTGIGEQRDAMKAKEADQSLRQKTRERVQPKMGKMDIDYQKLHDAFFRYQGKPSMSKFGEAYYEGKELETDLRTKKPGELSTELNDALSIPPLAPPPWLIAMQRFGPPPSYPNLRIRGLNAPIPSGAQWGFHPGGWGKPPVDDFNRPLYGDVYGELQGAEIAQHQNQIDHTLWGEIEDMPEEEEEESEEESEEEEEEEEESRDVPADGLATPSGMATPSGYQSVTSTVPGGLETPDFNFSELRKNARPQADERPSGPRELYQVVPERETSSRGFMGSSTTYDIGALGQNGGPAVLGAEDGGRKRKAGDVEISLDGDEDLTQEQLRAKYEASRSQASKVYVPGADVDRSGFEDVVSGEMKKRARKDEKKGREKGEKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6H0</accession>
    <name>A0A1E3K6H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035451.1">
        <property type="nucleotide sequence ID" value="XM_019172509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6H0"/>
    <dbReference type="GeneID" id="30189540"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25056" checksum="0DD69A97744556E1" modified="2017-01-18" version="1">MPPKIPLFSKQPAIARNIAARHFSSKPHLLRHRAELDYLAPFRRSAVPPPSRADNQLQNVLNTSKQPEAYSEGHLPYVTSSTAPVANSLQEVPAHGTGSRVADPVPAMKDTSGDNSANKDSGKGFRSKQMIVQGVAVPPKPIAPGEEECCMSGCVNCVYTIYSEELEEYVAALDAARDALERAHVPKSDWPAEVGTSGRGDAAKGDEKDKAVEGIDPAMSAFLALENKLKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6I1</accession>
    <name>A0A1E3K6I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035544.1">
        <property type="nucleotide sequence ID" value="XM_019172602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6I1"/>
    <dbReference type="GeneID" id="30189635"/>
    <dbReference type="OrthoDB" id="2573853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="418" mass="44938" checksum="FABBFEA4CC4A0390" modified="2017-01-18" version="1">MAFTFSFPAATTAASTEDFLFHTSLIPISPTAPHRSAPCPPKQPARKNGRHIPMKEPSQCGLFTVSEIPEVPADLSFDSDMSCDESMTDADLSILQTPSLSPEPRDAQRRFSWSSDGSEERQIVTPHLGMEGEDPFASWSTIPLEDKVDDEFEMVDAPSQPSFTPFAKGISRARRAPPPLTLTTRFSLPPSAAATPTLSGFPGSATSTVADVELLTPLSSVSTTSSLMPALPIVPAEQWTTQRVHSTFQTPTTPTFSSLGRSTQKRQSPTATVDLASALEELLTSCGEAVTTCSLTSPVSDSDDFESRSLRFPSARDINTPEKKTKRSAAPYAPRKPSRAHPHSQLPKRREAAELSSSPLEGDHSFLTCLARSQTPESGRSVKSARSAKSGSSVGSAGSGKLPGRKSLPMEWRYGQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K748</accession>
    <name>A0A1E3K748_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00479</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035601.1">
        <property type="nucleotide sequence ID" value="XM_019172659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K748"/>
    <dbReference type="GeneID" id="30189692"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="567"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="652" mass="70445" checksum="C60CF5F2C9F5DC9D" modified="2017-01-18" version="1">MSSKVIVVGGGLSGLSAAHTILERGGNVVLLDKNSFMGGNSTKATSGINGAGTQAQQENNIPDTAAKFFNDTKTSARDLARDDLIRVLTYNSASAVNWLVERFQLDLSKVSRLGGHSEKRTHRGGAQFPGMTITYALMEKLEDLAEATPERVKILKKAQVSKLLEENGKIIGVEYTREGKKHTEYGPVILATGGYAADFTPDSLLKQHRPEYYELPTTNGDHCTGDGHKMAMAIGAKGVDLEKVQVHPTGLVDPKDPEAKVKFLAAEALRGVGGLLLDNDGERFVDELQHRDYVTNKMWERNKFPVRLVLNSTSSKEIEWHCKHYVGRGLMKKFTSGNDLAKEIGCSPEALKKTLDEHNKYAKNPGTDPFGKKFFAGGDFSMDDTYHVAIMTPVLHYTMGGLEIGPDASVHDAQSKPIPGLFACGELAGGVHGANRLGGSSLLGCVVFGRVAGDSVSSYLLSNLANQTAANRLGNIQNHLLETKVRIDPSTRNVNLEFSWAEGGQAVPFTSSQGQQNQVPADSGPAKEGDRTVAQVEQEDLPPTQEKKKEAEGKGKGAKKAGGDGEVKVFSVEEVGKHNKKEDCWVIINGQVLDVTNFLEDHPGGVKAIMLYAGRDATEEFEMIHPANAISKYAPDTGEYPLPHIAQRAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7C0</accession>
    <name>A0A1E3K7C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035750.1">
        <property type="nucleotide sequence ID" value="XM_019172808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7C0"/>
    <dbReference type="GeneID" id="30189847"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="12663" checksum="179ECA19784FC9F2" modified="2017-01-18" version="1">MSAPLNNAAAAQTTSKLQAFLNHPAGPRTIFFWAPIAKWGLVAAGLKDLQRPAEKLSVSQNVALAATGFIWVRYSMVITPVNYSLAAVNFFVGCNGVAQLYRIWDWRQKNPNAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7G9</accession>
    <name>A0A1E3K7G9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035800.1">
        <property type="nucleotide sequence ID" value="XM_019172858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7G9"/>
    <dbReference type="GeneID" id="30189897"/>
    <dbReference type="OrthoDB" id="2567022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="23021" checksum="3B2A23F9C3A7C73D" modified="2017-01-18" version="1">MGRTVGLPYHLGYPLLSCTLLAIAAFASADSVWYVSVATEDTIVRFASQNYCGYNVSNLVITGKLGCIFRGFQWQIPTGYFGFTVPNGINMNLGRVVVCNVVAFSLVLISGAHHAYTIRYSYRASPAPNKDKLYSLAMLHFISVTVCFAFTWIAFIAQAAVIGHSVSQSNSLIDEGGVAVYWGQSAFLVLAAAVVHTGWGYEAVRWRVSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7Z3</accession>
    <name>A0A1E3K7Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial ornithine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035493.1">
        <property type="nucleotide sequence ID" value="XM_019172551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7Z3"/>
    <dbReference type="GeneID" id="30189583"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000220">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000208">
        <property type="entry name" value="Mitochondrial ornithine carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="255"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="37535" checksum="99CE74FC6143A561" modified="2017-01-18" version="1">MSEEPKTSALEDVLFGSVAGMVAKVFEHPFDLIKVRLQSQPTDRALQFTGPLDCFKQTYSREGWRGLYRGISAPIVGAACENATLFLAYKKCKETIILLRHGGEGSQGLELDMQETAIAAAGAGTIASFVLTPIELIKCRMQVQMLAREGALGGTPSTSAPVPGIHPFATTPNTTISHTAAAPRLSSPLGPVALIFDTIRQSGVRGLWLGQTGTLLRETGGSAAWFSAYEYGARHFIRRHQKKIGSARKATKADLTGLELMASGAFAGVSYNVILFPADSIKSTMQTSAELNPHKAPPGFFPTAKDIWRARGIRGLYAGCGLTVLRSAPSSAMIFYIYTRLESEFGGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8R5</accession>
    <name>A0A1E3K8R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035488.1">
        <property type="nucleotide sequence ID" value="XM_019172546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8R5"/>
    <dbReference type="GeneID" id="30189578"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="247"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="457" mass="49380" checksum="5B15A3CA2979DE63" modified="2017-01-18" version="1">MVVHTSDPRVKDLKSEALPAPLGSPGRQPSKKRSWGSMLVLLGIPFGALGVLGLTSSHWHSGPQTAISRLHSFKGRDSREIPDAAQVINPKDFAVLDYVQPGTEFNGFSLFVPPGATEDSLKEKPFHIYDESFYDIIGDSPSLTLLADGGDNPLFHEAVVWHNETDEVFFAQAAAMDLGFGLNKSAVVQKISLSQAQDVQEGTRNSTDVTVVNSTTQVVNPNGGTAYRGKIIFTGQGQGSNVTSALYELDPNEPYKTTVILNNFFGRQFSSLNDISVNPRNKELYFSDVTYGWLSGFRPAPIIANQVYRFNVDTGVVQVVADGINMPNGVTFSPGGQYAYISDTGISAGNFGTNYTYPATIYRYDVQDDGSFENRKVFVFTHVGNADGLKTDSNGNVYAGVGDGIHVFNPSGLLIGKIYLGETSANFAFAGDGKMVIGAETQLYYATLAAKTWNPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8U5</accession>
    <name>A0A1E3K8U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035517.1">
        <property type="nucleotide sequence ID" value="XM_019172575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8U5"/>
    <dbReference type="GeneID" id="30189607"/>
    <dbReference type="OrthoDB" id="2578230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33712" checksum="0B93E1EDFD92513C" modified="2017-01-18" version="1">MRSGASMRSNWDRWRKAPKGGNGGRANLHQGAIHSVPRGEGLLQPAEAGDFQDEGGVLERCQHFLDLNQVLFRQAAPMPKNGADTLSMGDEDPSSVQLDLIVQHILGKHDDVEDIEEKDDEEEDKDDGDGDGDNDGDNDGDNDGDREEDDDDDDNGDGEERPPIAGRRSNSQVIATPNRRSVAGNCKAAHKPKTPLSLHDSAGKGMAADDEMERLQKGAEEHTQRRHDEMILVEKEKMKAEKERLMAEKKRVEIEKKKSDQEVLASKLEMWHNHVVFNMERRNMSYEDASADASAMMPSFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBB1</accession>
    <name>A0A1E3HBB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000065">
        <property type="protein sequence ID" value="ODN73620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027770.1">
        <property type="nucleotide sequence ID" value="XM_019180250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBB1"/>
    <dbReference type="GeneID" id="30197495"/>
    <dbReference type="OrthoDB" id="3863592at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18135" checksum="22DF30288EC4D70D" modified="2017-01-18" version="1">MTKSAACVRRGLSDNTTLSTESSNPTSPVSPAPSSLLSHQPKKGEGGMIFGYEEEEVYGLEDKHMYMVDGRGKPREMEWLDWVQGQIVAWLSKRDAEVVSKALRIYGGAFRPLVLSAGGLMSEETAVELRSWRKGMEKEVWHGMQSRVGIELVKARARTMWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HDP3</accession>
    <name>A0A1E3HDP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000061">
        <property type="protein sequence ID" value="ODN74255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN74255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="14" mass="1688" checksum="C3E9BB752A992206" modified="2017-01-18" version="1">MYEKAHQEESPMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF79</accession>
    <name>A0A1E3HF79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027881.1">
        <property type="nucleotide sequence ID" value="XM_019180155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF79"/>
    <dbReference type="GeneID" id="30197395"/>
    <dbReference type="OrthoDB" id="2564610at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="706" mass="79237" checksum="90AB0DA07EAA8811" modified="2017-01-18" version="1">MSSRTRTRPPTARTPTKRSRPSPVSTAPAAQPVDRKCSQVPRVAVTGYMRKSSKTVEQRIVKSQTESVESVQEDVASFGSARYDRPLVGGGGWADRLQPVAGPSRPTRRVSPMPSIPIGTFESQKTAISLASLPDPEQLTIRIALPQGTCLDETEAGNWYVAGEEVLVEAMRKEKEGVMERRGWNGKGKGKGKPLEENVMWLSAPLVHPCICSVEAYANRYTLAHPPPQHRTLTPLPPHPKPSHIPKVGANLAGWTQGLDKDLDMTLDEMEEFEECWTAVPAQVVPLPVVEETDVQDDWERLLPARDLSAPSRMTSPPPRAGATAAAQVGGELQGSEASVSMVLGREDVAKRRSAWWREQYASDPVYGRVYKIIKPRSREPPIFQKYPRTTPVPTYTPPAQLSSWPYHPYHPDIHHYIQKRPWARVCWVIPIHGPVHIPGINDPLEPFVPPVSAAGGSPKKAPMIPRQLIPSSGVLALDSASLGAEKSASTIYWTPQRLKYFIQQWLIPSWQDDTKGLFGPLSWAVQSGNLDWWNLRDVGEGRREGEGLHVEVPDGIAGKKSVKAEMGDCLRIWCDARRALSLRMAICRTWVPEKDYSQLDPTWPVPEPPPDPATLSEEEDDYELGTWEEKGEWMEVRERRKKMEARRMKMKEARREARKDREARKAVRKEKRDEHTAEIEKTRVMFLEKARLTLLDDKGQVLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH04</accession>
    <name>A0A1E3HH04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027898.1">
        <property type="nucleotide sequence ID" value="XM_019180129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH04"/>
    <dbReference type="GeneID" id="30197369"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="85" mass="9394" checksum="DF2CE2F184512A46" modified="2017-01-18" version="1">MGGPKPRLVYLLNEELNVPRPTTITIEDPSGKIQEAATSFTKRIDKHLVQDFAAQETTTAVAEGGKTKKGVSFWDFVDLKLKGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ90</accession>
    <name>A0A1E3HJ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_08087</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027960.1">
        <property type="nucleotide sequence ID" value="XM_019180059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ90"/>
    <dbReference type="GeneID" id="30197298"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="226"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN76403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48619" checksum="820339933F08E847" modified="2017-01-18" version="1">MTLVSSTRVRLSPPPQSFHGDDSDTSIAVDVYFTEAASKKYVPRSIQVDLEPGVVDLVRSGPLKELFRPDTFVHGESGAGNNWAKGYYTEGAELVDPVLDVLRQQAENSDCLQGFQVLHSLGGGTGSGLGALLLGKIREEYPDRMLATFSVFPSPKVSETVVEPYNAVLSTHNLVENSDITCCIDNEALYNICTADLKIPMPQYPDLNGLIAKVMAGFTSTFPGVLNSDLRKLAVNMVPFPRLHFFTAGYAPLVAGANKSYTSSNVHELTAAIFQKRALLAAVDPAFGKYLTVSVAYRGKLSMRDIENAVWDFHNKNSEHFVPWIPNSSLTTLCEVPPLGQKAAATLVANTTSISEVFKRSHAQFRSLFRRRAFTHWYTGEGMDEQEFTEAEANLADLCIEYDQYANADLEEEEYEVEGEYAQEGEYEQEGVEGEQVYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HX15</accession>
    <name>A0A1E3HX15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028220.1">
        <property type="nucleotide sequence ID" value="XM_019179798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HX15"/>
    <dbReference type="GeneID" id="30197027"/>
    <dbReference type="OrthoDB" id="2597010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="694"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="906" mass="100530" checksum="38F3C9F8A4B5DC5D" modified="2017-01-18" version="1">MNQQTPLSSFLPSYDPPLYLISTIPPACIPTSMSNALERITFGPRHFYDKEREAEATDLSQVDRHASLDMGGPADRTTDEHEVTSDPLTTRKRAAEAGPLTSRTSPTKRLKVKKSSPQKKSSPQKKSSPQKKKLDASAKRTDSSSQRKPDSGTALRFWQILKHFTFRYDSEVVPRLVRGLITVVSDLTALNLDESQALNELVQFLFQLENRHSVFLPEPLRQFERGDHSYDFDTYERRDKKEGSDVVWLVGYGGKEEGSTALAFSGECQAANIYAKHLSRLAANDSSISSQLESCIYQYAPPVKSGVLDLAARPDRDSDAKKGQYQVTISTKLGIEHKFHITLRDLFVLFYVLLRKDIKIKVDPSTGTSVEGSEAKKMLSTALINILAQLAQDFHVNRCEYINLAVHDFSVTFQLMGRNIAHVSRIVFRDPATARRDILPRDELTKILSGIQPETDRDAAVRMLLELEPWETVAKHSLFAVLVAGLVLPVGEDTKSMWIDGDKEGLGEPLDTSATGPTSEVPTPQGWTAGSSTTTTTTDTPQSGSTATGGTAFKMFPCPAVAADLHCLQGIDTTHHQSMYRLPYFRWVEDPTFCVQVSRGKTRLSDVSDNSASSGSQSTPSLTTDESGTPPSSPVGPTSPTTATSVGSVVSTTGDEKSIRREPEDLNEEDLNELLRKTDHQTVLSLLSRPDLSVELHEYLGSGRLWDAYRVKLSSGSTPSPPQIVVAKICNLYTFTLGDGYEYETPSAAADAIKTELDLLNHLQAVQGEIVPRLYGRWTGRCQLPSGGTVRLDCVMLEDCGRAIVPSHKLETWLYDGDEVERFPTNLSSDVRQQIIESYERLHKQGILHVDVNARHILLHPVDKKPRIIDFEGAISISEAQATNQDYDAEQEMERVRWLVRADEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1V2</accession>
    <name>A0A1E3I1V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028304.1">
        <property type="nucleotide sequence ID" value="XM_019179687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1V2"/>
    <dbReference type="GeneID" id="30196910"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29537" checksum="F6D159196D6F2C52" modified="2017-01-18" version="1">MASILLGEPNTLPTDPIVPGTGSEKKKRQIPQVAFYVAGSAFVMTIGLTAMVIPYVRQAARSINRPEFMSNRHMPILASRKYPSPLLPPSASAPGANSSSTSASAPLGGKAKTSALPAYSHPTFAAEMPISEKDILREQVAKSRLFNAREEKSLFGGSLMLQKKDGSALREGEEEGEAGEGGEGGKEGDNMEGALLGAKAFGIATGIVFGCAGLGMWIVGKAVGAEDPEDFAVKMRQQLVTSMPALVTSVNKPGRSVDGFDGQAIEEWVEGLEREDERPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5P0</accession>
    <name>A0A1E3I5P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028384.1">
        <property type="nucleotide sequence ID" value="XM_019179616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5P0"/>
    <dbReference type="GeneID" id="30196837"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="7"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="38705" checksum="4F28E315DAADB2A6" modified="2017-01-18" version="1">MSIKEHKIAVIAGDGIGIEVTASTLEVLRAVQKKVGGFELIFDELDYGSARYKAKGSYTPEGWLDHLRKYHAIFFGAVGDPSVPDHISLWDLILPMRQSFQQYVNIRPSSILPGIPARIVGAKPGDLDWVIIRENTEGEYAGQGGRTHVGTEWEVATELAIFTKKGVERVMRFAFETAQSRGKKQLTVVSKSNAQRYGLLLWDEVAEIVSKDFPDVKWDKMLVDAMTVRMVAKPTSLDTIVTTNLHGDILSDLAAGLSGSIGIAHSASLDPTRTSPSLFEPVHGAAFDIMGKDLANPIAAIMSAAEMLRWLGEEEAGALVEKACKQSVADGKTTGDLGGKLKTSEVTDVVVKILEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA07</accession>
    <name>A0A1E3IA07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028481.1">
        <property type="nucleotide sequence ID" value="XM_019179535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA07"/>
    <dbReference type="GeneID" id="30196752"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="57702" checksum="6E2C0E91F192D371" modified="2017-01-18" version="1">MAFNIAPIQNFLKKEYPLPKPDPRWIKQCVAALQAAGTEPSEQSVQSEYLFTDLAHCTLPSSAIPEGDLHNVILFPIPTLLQVHSVTEIGNSAFQIQTVMEQRSEVLSGRTRIRGLGDAEQEANGEEGEEEEVEDGRVPPYPRSMLKLDVGDGRKVLKAIELQRIPDFVLGQTNLGSKILVHNVKVRRGILLLTPQNTQVIDSCVDDLEANQREMFVRDLKRRLGKLEPGEDNGEAAPRIVIPPPVRDGGQRRGAGGSQPRARARPRARAEPRAKAEPKSEHQDAPAPTTSRFFKAPKCSPSPAAGPSKRPAQIPTRPRNRSPTPDFDDEGDSIFDAFDESFYDHVDQAAAQLKSTASGSGTGGRKETELFEEAETDDDDDGDFMILDESVIRQLDDMSSRPKVGAPSTTTTTQGIRQKSVATSSSTSKGKPQYIVPDDGDETDYGMDEDLDQSFVRQVDEQVAALVGASKAASRTVQVAASSKCSLGTPAASAMRGSQWKKTFSTDISSDEGDLQKENRKPEVIEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAN6</accession>
    <name>A0A1E3IAN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028525.1">
        <property type="nucleotide sequence ID" value="XM_019179487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAN6"/>
    <dbReference type="GeneID" id="30196704"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="250" mass="27688" checksum="D718CA27C2176F40" modified="2017-01-18" version="1">MSPSITLHHLDVSRSNRIFWALEELELPYNVQVHYRLPTRSAPPSLKQISPLGRAPALTIDGKLYTESSFIVHSLLALPDVRVRAKKGEVQVQVEETEGDVFWSHFAEGSQMNLFQASATVGATSAGWLKGAPGVPELSEEAKKGIQQYTGWLQEAYLKPNIQSTIDFAENALAKQDAPFFSGTDKPGEGDFLMFFAIDSLLQGTRKDAGFTVGPNLKKWHETVLARPAAQRGLKRQAEEEEKQRGKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBV4</accession>
    <name>A0A1E3IBV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028627.1">
        <property type="nucleotide sequence ID" value="XM_019179379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBV4"/>
    <dbReference type="GeneID" id="30196588"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18657" checksum="9A4ED16EA58A69F7" modified="2017-01-18" version="1">METNLAATTAARKERLIALRRKKEEGETSGTFALKQRNYDPETRNLRKRDAEDGNQDTVEKAVEGLAEMIIKEDEEKRAEELDLFNIQPKRPNWDLKRDMDNRMSKLDRKTNEAIATIFRQRLQSLRKNQDPSAQVDLVASINAAEHERDEQTREESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICJ4</accession>
    <name>A0A1E3ICJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028704.1">
        <property type="nucleotide sequence ID" value="XM_019179348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICJ4"/>
    <dbReference type="GeneID" id="30196557"/>
    <dbReference type="OrthoDB" id="10436220at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="468" mass="51936" checksum="5D972E34B6205661" modified="2017-01-18" version="1">MAEAGPSTQTRGSPAVPQSVNRSSVSLYPLSGILRSIWDVPAVAPTTNPPIDTLSQSSVPNAYPSDIGHPGNGIFGGPLRLVPFDLSKSHHYPNGLTIKPYENVDQDWMGSHWIECYPSIQHEHHFQYQHVVLYLREFYVDPKAVYPTSWNTDVNFHSNRFYIPLGKKFTDLEIVKSVREHDPKLLKTGTSEVTSQMSTKFSGIKPDVCLTGYHIGTLAEGTYRQELEGGGKLRRPIAPKGSSTLKSSSKLDEAEELDIRRTIDQHLKGLQYANMEAITQTIFYSLLGHDVSKCRSAMALVNGNYTRILNLSHLVPEGEEVDWEGVALGAGGGRRILVEADPDVVAKLRRRDNHCLSPEQFGLLAAGEPFNGIQWQAPNSIIANYEDWTLDQGAKDRLDATQLVFFENSALYPLSESFATAQDFSPDLSLGHPPTYYKAGGKSTLSQLSTYPFLLLLLRQPIKSSHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE13</accession>
    <name>A0A1E3IE13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028815.1">
        <property type="nucleotide sequence ID" value="XM_019179198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE13"/>
    <dbReference type="GeneID" id="30196397"/>
    <dbReference type="OrthoDB" id="2568950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129697" evidence="1">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12014" checksum="214AA037F6458D94" modified="2017-01-18" version="1">MLFNAPALLTTTLLVLTATFPVSAVDYRLLANKPGSGSIESFKVSFKIQCPFFNPTNNTNANHRSTFFVPGDWQGQNTDSQALVYCTFTKQDGTAFAVTRELVDSLGGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFM3</accession>
    <name>A0A1E3IFM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028974.1">
        <property type="nucleotide sequence ID" value="XM_019179056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFM3"/>
    <dbReference type="GeneID" id="30196249"/>
    <dbReference type="OrthoDB" id="10536488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="16614" checksum="AE5A7791379FA8CA" modified="2017-01-18" version="1">MTSYATLNEDVLPGVHEVQPITAIEFEIPIGHPEATYEIEPGSRDDERFMSVLSCPPPDANAFQAEVTCFHSLSKRSSGEESLIQHKKDVYITKEPMTVISDLTSFKAMFDQAAYETAVNEVFVDSIESVAGSYLFMFFGQYPTIYPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFR4</accession>
    <name>A0A1E3IFR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029003.1">
        <property type="nucleotide sequence ID" value="XM_019179084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFR4"/>
    <dbReference type="GeneID" id="30196281"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="525"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="820" mass="91439" checksum="8ADEB0B247A07B8F" modified="2017-01-18" version="1">MPPPYSFAAPVAYRISSTAPPPPPHYDNNSKRKRSAGLELLRSKPATKTTATSPLSPTFSLPPLLSPAQPNTSFASFPIPPEPPQEQYDQFATQRATLRHAKSIPHLLPLDLPPPPQEPRESKEKKRKYSSKWERGTLEAHLEGTGGKYGGELRIYNPDCTVFHHPLNTLVRHSPSIEDVTKVHHSVYGHLHTLSFRIPTVSSPEPADGLPSYALQRNASKSRPGLMSNLFTRRRRGVTISLADSFAKNGNSSALGEYPDEPSASVLSVGSTVMSDQSETETNADTVVLLVFEDAESLGEWYLLLKSFTMKETPRTLRRLHVRILDLQETATPTEFPLQTASYGTQLGFGSFDIRSSKSSDALLPGGKGLKAGWAAKEHICVEMPRRITGFLSGLSLLFSKTSPAFPSVARMSICILRSNKSHPIATVPLSLVPNYSPTRDERYPVVSLSNEAVVGELRMAVSYQELPILHRSTYVTELYTGGDLGARAIYVMSSRGYFEQTHDVLFKVSLVKNPTFPWLLEMVNIEAKSDGATLFRNNTPLTRSLESAMKVLCVDFLRLSIGPTISTILENDIEVRSDNLNVMDRLVKGCWADMYAQRGTFPNPLRKVFAHLYKTVKQNHEEQMLHYKSVSSFLFLRLIGPALMRPHLFDLARGLPRAGIQRTLTTLAKILHAMAFFSDRDISRDPELGKYGRFIKNTANSDMMFDYLASFSTTLDEFQAAPPPPSPAATFFYERYPLLSPTEGTYVVFPSNAGPVDLLGEGAVFLETLYQRRKDVAGKEVYDEGDVEERVRLMDAFHEKVHEAAFPHQKGSERRKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IG96</accession>
    <name>A0A1E3IG96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029005.1">
        <property type="nucleotide sequence ID" value="XM_019179086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IG96"/>
    <dbReference type="GeneID" id="30196283"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF26">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="9">
        <location>
            <begin position="835"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1263" mass="139282" checksum="3D42FAD89D847675" modified="2017-01-18" version="1">MPCKKTLSRLFTPQAEPPALDRGNSMPCSAQLFDLLKFVAGGGGAPADLTMADLSDEDEAAAHTDSSASDADPSGMPDTSASVTPDKSSTEAHDDLRRTWADETMRNNRERDTMSSRFTALSLNNLSASMSTEHVNKNHPPLPFATMDDSPELAAPIAPPPLSRSQSSFSTSSASSEEAPDVDELANVGTTFDGDREISPEEKLAAIVNEFGDVSSIYEGDEPERILAESKGSLFKSVMVVGNLHLTTHRLLFHAYLPPDNETWSNLSAQQTADVTNDAVSHQPDLLHSGPVTIHRPGPIRTSRRVWMELSSEMVTTFPSADEAGRVRPLRCVLLSSIKKCDPLDPDHPCDFYVTYDTPSGPRQSHFTVDTEQSAIQWRRALDAAIFRQIRHKWRQIAPSTNFPDSSDWSVIRICIPFDRVTLRGVNSFHSFATLVGMDIAMDGVRISKAMLPVVKGDWSTEDPVGSEGHKPLLSPSLIRTQKTGSFLHRRSLSLGRRPQSPARSDVPKSSDAAVYDSLETLGLQSSDQGTISFNIGVLNEQAWFAQAIRSAVHASQGRKCKPAMKRPKLVWEVGGHDCLATDEELDAEKAQSGSMDSEEAEEDDDDGGLVQETRKKEKALMAAKVFGLKEEEGIWIKRCYVATALIPARGHIIVTPRYICFWRRVTVGSDIKYRFPIEDVKGAATAPSLRTRFHGLALQVHGYKDVRFEFWNKEARDEVSLQNDLNSYEADDEQVILRVNATCATRGRGHRRDYSPSHQDSQSQPATPVSFEGIERVASPVGDPLLEHPADILVPPKDLLIKPVPMNDEVISYMPFVANRPPGLTSIKPRTFTCLTIGSRGDVQPYIALGLRLMKDGHKVVIVTHGEFKEWVEGYGIEHRQAGGDPTALMKLSQEHRMFSPGFFKESLGAFRQWLDDLLLDSWNACHDADVLIESPSAMAGIHIAEALKIPYFRAFTMPWTRTAAYPQAFLVPAFEMGPSFNYSTYVLYDNIIWKATAPQINRWRKKHLGIKGTDMAALSVTKVPFLYNFSSSVVPKPLDWHDDIMITGYWSLEDSDSDWSPPAKLDEFIAKAKEDGKPLVYIGFGSIVVPRPNAMTKSIIKAVEKADVRAIIAKGWSSRGGDPATEGEHIEFPASCYGVDKIPHAWLFPRVQAALHHGGAGTVGASLRAGIPTLIKPWFGDQFFWSIRVTKLGVGLKVASLHADDIASALTKATSDKVMIEKAARIGERIRSENGVDTAVKAISDNIIRAGGDRRKMQWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGK6</accession>
    <name>A0A1E3IGK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029072.1">
        <property type="nucleotide sequence ID" value="XM_019178978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGK6"/>
    <dbReference type="GeneID" id="30196170"/>
    <dbReference type="OrthoDB" id="2596255at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="857" mass="90572" checksum="98058D080B3CAD69" modified="2017-01-18" version="1">MTLHWQTVSPQTRPLTLTVLDLTPLALTVSLSLTPSASLPLQPSTHHAHGVHGHPSQSSSNSKRKRNRRKANGSALSTAVQGEGSEDDEHEVEDSDGGVSFKDLLRHGVLVYVNGVQSNNLFANVMDDEDDDEWEDDPESVPPASSEELEENMEQGVTRRRPRNARFGASAAEAACKPPGKKKDEKHHKGDKDRAVLVIYGLMPGKEYEVELRVVGMGGQEADPTPSTSVLIPASPGQANSFHPRSRANSLRSRSRPRSRSNSLTTRQFEPTPAESTPAPATEAVIPTPILNPIDTQAAQLRHAIATLHSEKDVLQTQIKEARRTAQRQEAALKQEIEGAKKGIDKAGGMDLRAKQKALALQEQVKQGWAGAESAEKEAGEVESGLGDLEKRLEELKAEVDQVEREWKGAKDEEDRVKEDDKKTRVEEDKKLQDVVTKIEKLRTKKVKREAEGADLEKRIEELEKECEEVERKNEDEKASRSRTMSYYAAGYGQNQPHHDDAPAFGPVGAPASRGITQHQSLSNLAGGYAAGPAYRPRAVPGYTPRFPSGGARPSPPLPSPTHGNNLYPISHPVPPSASACSPSFRAPKLGPMASRPGVNASALPFHPATIAANAANAAANASPVSSPGAAAPSPAAQEHTTSLIPPGLQHRIYLPHNPSRPGSVRPFQPSPLHAERPGTPVSATKVPGLPSSPTSADSGAEGESSPAFPPLPGSGSKSSPPPPAGGSQQGPSLASIVTRAVLSPTSALVQPGQPSQTPPQSQGSTPQSQVQGQARPSPPPGMLGQHPHPGMIKRQSYTGDFPALSPKWGAPVPAPGAVGGTTSRGPSPPGAHLNGNTNGRGSNSGNGSTGAGSQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM5</accession>
    <name>A0A1E3IGM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028860.1">
        <property type="nucleotide sequence ID" value="XM_019179102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM5"/>
    <dbReference type="GeneID" id="30196299"/>
    <dbReference type="OrthoDB" id="2572208at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="45781" checksum="768D202DE9BD7FED" modified="2017-01-18" version="1">MAPALPSPDSSSSKRLVSASAFNFSLGSKSTKKPRTSVTTGVPRPTDGHNLPRSEAKEPAFSEDDGSRSTKSVLDKGSERSEWSSSGRRGVSDLSSAKSPAIEWPVQDGRNMADLRTSPVNLGSSSSTASIRQPPRFLSPSIPRGNRPTLGSSSLVPLSLRALPAAQPYNSRSGTKGKDFTPVTAPFERVIKREPLEDEKKMSLVRLGETRLSDKMTEDIIMRKKVVVAEEDEGVGVSPRGKRVTNWPSARAMPSSVQLANLLSSAKASQTLFYTSLQNALFPASRLAGRKRPDDDFQSSHLTAGQYIHQSAATILYPVEAIGQVHGTLFFWCDIHPQFSPTQERPEPKRVLAVLQPWAWDGPRLGVDPQLMRSRMLEGTGKRWLVGVWAANPIDMTMSGDISGKALMVTRYLIAEQDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIN0</accession>
    <name>A0A1E3IIN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029276.1">
        <property type="nucleotide sequence ID" value="XM_019178793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIN0"/>
    <dbReference type="GeneID" id="30195951"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000014">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="242"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="566" mass="61760" checksum="C86887416ABCC74D" modified="2017-01-18" version="1">MDPNAEDKPKSVQVVELDVEPARDIPQEPVRRADFGRTENPIVPPTIQAPLASSIFRQALEPNTPPPTGPALAAEPITEDPKKIKQWQEEEFHRRLRGEYEQAQRRVGDVVTDNMERPLRLTSIRLSPPPPTTRASFTSSLLSPFISRPNPNLPSWLNPAPPPPTTLHEILLSTRALVGHVGQFGVYDMDRVNVKLEPRRGGDPDEVEMVLTLREKGRLFLKAGTEVGGGEGGGNVTARIRNVFGGAESLEGTASLGTKTKHAYQLSLSSPIFASPLLNFALSAFSLDRDNSAFASHRERSQGGRANLSMIAPWGTHDLQYELISREVDRLSHDASVSVRELAQPSTKSSISHTYTSDTRDDPWMGTAGRLLKVTHEYAGLPGSDKFAHFLKTVTQTQLSRELFAGSGVHFSLASLTTFLYPLFPHSPTSQSTTYLSDRTFLGGPNSIRGWKVGGMGRRDGPDSLGGDMSWGMGLSLLGPIPGKPNWPVKWHGFINGGKVSAYDTSRSFVDNITKMYSSPSLSVGLGLVYRLDPLRVEVNFAVPLIGRKGEAFSRGLGVGVGIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKM2</accession>
    <name>A0A1E3IKM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mesaconyl-C4 CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029435.1">
        <property type="nucleotide sequence ID" value="XM_019178528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKM2"/>
    <dbReference type="GeneID" id="30195681"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39188" checksum="D03E4B7715A9C70C" modified="2017-01-18" version="1">MPTTPPARRAKRPPFSSAMPIINLLHPFFTLTFVPMLQRSMNLLCRSQRPSTRTLFPRRIHTPPSLQQWIDHITARSPQRSHDILDPDRASQLQRALPTRQGGGYIDDLPGGAVLPAAHHLVYFRPRPMLRDLGEDGSATELNPPAPFLRRMWAGGEFHWPSPSPPATLSSSPPSLPPPPSFSSSSSSANVLKVGEPVTQVLTIPRVEYKKGKVGRVGGQTTSSPAAPPSTSTPDPIYNHTYTPTTPLLFLFSALTHNSHKIHYDHPFSVSHQHQQGTLVHGPLSALILAEIADSVARQGTEGGDKAKRMVGFEYRATGAMVVDREVVTSAWWEGEVLVLESRQGGKEGMKARARFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKS0</accession>
    <name>A0A1E3IKS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029482.1">
        <property type="nucleotide sequence ID" value="XM_019178575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKS0"/>
    <dbReference type="GeneID" id="30195732"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="249" mass="28274" checksum="7E0C350F5A9F1F9F" modified="2017-01-18" version="1">MRVDGRFSVVGRLYGTVFLFLSCTNDPHELFMMILRPSFLFLFLTSLLTAVSALKFDITAEKDPKPKWSKSIWNFAASHSLVIVTANVPSEPDQRVDIEILDGSAHGNVYLNKKDIKGESRLAVTTHENADVGVCLRNYWTGAGNPRAVRSVELDVDIGSDAVDYNAIANQESLSILEVEMRKLEASAREIVQEMGYLQKREMRMRDTNESTNERVKWFSILIILATIGLGVWQLLHLRSFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILM3</accession>
    <name>A0A1E3ILM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029404.1">
        <property type="nucleotide sequence ID" value="XM_019178703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILM3"/>
    <dbReference type="GeneID" id="30195860"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="38981" checksum="B0555BD96C429889" modified="2017-01-18" version="1">MSDGDIDQLARGEDYERERLDNIRERDALLLSLGLETKPQPAPRTSTPVKRPTLSKEEKQRRKASKMKELAVRREQPTRKSRRVEEREDGKGREGRDRRRTPSPGPRYDPLPKAIAPTLAPGPDYAEAEGETYYERAPRPTRGQDGRLEFEGRFKGVFAPNLTPEEMFAGGAFGGGFFRDVYSRVAHRQLSSTESTASLPFSPSSSALPPHLYPRLLTNPTPQASVNRFKVKAGQSLQEWEEAGWIWAGDPRGWAEWYVRFWEGRRGGDDGRQVNRWLKVAGPTGRFKRALLKKLLQAGAGAGGNGSGREMVEVVEDEDVGRVLRQCLWQWGYVLDGGEFERALGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMJ6</accession>
    <name>A0A1E3IMJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06499</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029461.1">
        <property type="nucleotide sequence ID" value="XM_019178554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMJ6"/>
    <dbReference type="GeneID" id="30195711"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INJ4</accession>
    <name>A0A1E3INJ4_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">L198_06195</name>
    </gene>
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        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <sequence length="1989" mass="216927" checksum="61AAAAE9E98D7600" modified="2017-01-18" version="1">MYAPPGVDSDSSGEDTTPPPTPPPPKAPRPHFKFSSLFTPTRKLDLPPSPASTASHGKTTEKREEPAKEDAKKEEIKPTKKGVRIFAGELLGQKGSRAEGLTTTRGDRVEPEPPSPPVEDASFGAPHPEMIDVQQDHADASPATGVANEVLVLLRQLVADTHTKGKDKDFHGVGDSVGRPPQLKVDKAEPPATPSTPFSAPPIPTFQAIPPHICYGPGPWMGYAPPGWDGLQGTYPGFVGGQPVSAPLGTASQVGADVFSPTPLISSSPNVAGRGVQKEGKEKKTAGGDEGELSKKIQGQSTKDGLGERKIELTSIRDPTTSGTPKSSADYSTLKKSLDRYKTMYRNAVKRYEAGGEPEDIMKDLKAEVKMLEVKIKEIKAKMEKYERATTSEKTSAPQAAGVINDGTTDSPASNAAKPSKAAPPDPPSNLEADVTRYKSEYAKVLKKYKDGEGGDDMKSQLKDQLNKLESKIKKATGALGQSKKSLDANTTSETSQNVQKSKSDEPSGSTSAVRDISGGLPSKETKQRQESSPGIPPAPKLEDDIKQCKHEYSKAMKAYQNDGIKSEEKKVLKVRLKKLEEKIGKLSGTGEAKSTQDKPMPAEYSQDTSGDHKGTSQDGVKEDITSSSSTREPATDGSVPAKRLKTDKSSSDPLPSGISRSKLASDVSRYKDEYQTALDMYKKGNISDKEEEKRVKEQVRDLESKFKKALAMLEQANKELEATSDVVDQGSKEKLEPSQTPALKVSSGATTIQSPLREPLPAESVSSTASSGSPSSMQLQSDIKWYKTEYDEVLKSYQKADLVENEKKRLKHELKRLEDKINEASKLSGQANDTDDREVTLKEGTAGAKTNQTPNPPREPAANSTALSPRAASKQPDRSDPSASTNDITAEQLKEKAAKYETQYRHIVKAYKQDSLPEGEKSRLEGEMKEFKLKLKIINGRLEAGLATKVPKGLKQSVEEKAREKDENKAEEKTDEYAKVELEKRTDKRAEETVQSVDTSKRNTLAVSGLDTGKSHAPESGISPNATAQGATKPSSSSPNLQEYVKKYKAAYALAVNAYKQDGLSDEERRKRKEKVRRADEKLKEATQALETSTSDGETKHRPPEKTKQPSGGGASTSEPSKAPSKSSSPVPPTASDAERYVVQYKAAYQLAMKEYKASGLSDGERKDRKEKVRRAEEKLKEAMQAVAEEPKKIQEGRIAEKVPPPSGTNIEVKEEALRMDVKVQADPTKFKSQAGDQTSEASAKCATSSVSPKALSSRQPPTSPPAPQDPAEMDKLLKHYKGRYATLVNAMKEQSLSAEKKEAMSRQAEGLKARVKAMEVEERKGEHPREVKADRTGAQADLSESESKSEGKAVRNDSGALPVSPKPVRADKTTILAHHKAEYARLTKSIKDDLTAHDRAEKIKEADKLKSKIKSLMADLPDSTGDKKQEILASKEKAIGKAGTGPPARELTRDLAQVVSDERRDKQKGPQEETWAPLSITKSQSPADKQLAKSVSQVSPKQSLPREILPTSQSTWSSTLVSLAKCIDLANTILNTLHETTPEGSSILSTLVSRIMTSLLMQQDIIQSMRKILGDENSEASEEFVRHLSVVKNFLEGLYLGHGTGRTKEVREENLEVISIQSIIEYLLGLTDYLTPGMIAVARRTFDAWRTDGFTLQSFVQAIMGVRKEVRAIHDLKAREREEDGAQKAKGLMSVLDMLLAFISPEPSQHDEREREELITVSQTREVHRSSKRLTYIKGVSPDTDSSKALGSSETEHHHTVSDILHLPSRYLDSSTSSTAPSATRSGPKPIVITAEEHVHHTSKADISHSPLKLPQKTQDFLNGSDEPPQTLGQDTKSPQNLTFNDDERHRRLHREGSTDTDISPSRVITFNSSTLNSSKSSVPNAPEDDIWSAPSRYSQSSASSSLTATPDGTVKSDRHAARLLAQADSGPLPVRHDKRDEVDDMLDEEQLEPSAEEVKRAEDVLYNKALSPGAPVRPARRVADRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPR2</accession>
    <name>A0A1E3IPR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029600.1">
        <property type="nucleotide sequence ID" value="XM_019178444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPR2"/>
    <dbReference type="GeneID" id="30195593"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="285" mass="31983" checksum="2FB2AEB6DBF3A152" modified="2017-01-18" version="1">MSHPEDVYANREEDWYPGIRQRSKPGQAPHEQVYDTTRDINGNVVTDKPANRAILSAQKRQRTHDARVLAQRQKQAARAQSGQTEESSTAGMLGRMLVVILFLPLLSSFTTQSYTFNLSPYFVPPLKRFWAETPLNPWKLEMKEFTPLQLAMYDGSLERPVYLAVDGVVFDVTSNRRIYGKGGSYNMMTGRDASRAFVTGCFETHLTHDLRGLSEDELKSVTHWKKFFENNEKYTKIGTVLNPPIDPSTPIPPPCRGEKKDKADPHAPGAAAAQRGRAKPGPVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ43</accession>
    <name>A0A1E3IQ43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029825.1">
        <property type="nucleotide sequence ID" value="XM_019178106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195251"/>
    <dbReference type="OrthoDB" id="2563277at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1715"/>
            <end position="1736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1781" mass="192357" checksum="3055794A25DC7519" modified="2017-01-18" version="1">MTSSLLSPNNHTRHSHYLAPNQPAASHNGGFKASLRKIPSALFHKSPIRDRPTKGQVSAEPSVSHLQSMSPSLRVPKSALDTDAGTKSKLKNKNKPRKALAELFGWGHNTNTQPITSPAPAPPSKPINQGPTPRASSTMLRKVNRPPSTKSTSTSISLRPAEPLMPSRPSMSDDPFMRADVGAEVVDNVFRHGTPSLRSQTPMDRRSSVASSKALSYKTVSDERHSKEVQERPPHMTTIRATQQQRHISAPLPPHIASDLPPAPTSLGRALGSAPLVFAPLPGVPEASPVVVGETLKKTLKKEKTKSKVWGLLGRSKSKKSKAPVEAAPPVPPLPTKESWAQSSGPAQSTTSLVSKMDEKYAFATARTNYSSLRTSRVPVPAINATARSGSTLSGPRSEEGTVIYESVVGSTHDRPSTDGPRQAIEALMGPTRLPKRKSLTGLFGLGSRKSTDKLKASSPGRAASSPPRMMGQPTLRSLKEEREDVAEPFRPAKTASLVSSQAPKIPTPKADVFTCRFGSLPLNIAARAEVPKNQGGIRRVTSATDKLLNLVHAFDLSPASSRSPTLHHMSSSNTLRADVNGSPTPLRKVRSAMLGRPSSNSLKPSSANISPLKLALNRSQAAANSLKCRKAPELAENPAETMAPTPSPPRQSLVRKGMRNIFAPPSPVSNAAERPMLTPVVFSSAKLNDETVGMGINIFRHSSEPTVKVSDGSDLPFDLKPVVANTDAAKAQYSPSKTAKLGLPAAPPQNRVTPRRTGFAPPALSLPPVPNVGLPELEQSTPAPEATAEYNNRDSMFSDMLTAGPHDQHRDTFDFTSEYQALDQGTQRHSFVEALRKVGSVQMLMGGDLLPLPILSHETLKVSPTEQVPSFHISKPSDGTSLDNAHDDDSDGEEDDEDEAFGDDEGLEETAEIHHVMGIAKTSPVRREPFKGQVSFQQQMTMRTKASVASFGAPEPALPEELPALPAVPDAFAPTHRRGQSSVATMSSIGSVIGVGTEREYTNYFDYAVPQQQSHSRAPSVTETVEEIIDDLPERSPSRQAMANFKFGAQLNTRPTTRRSHHRRNSSIASVDSVGGVDLHNVIHGGPPVSMHNKNRSSYVSRHRRGMSGESSFGRPDWAAHRRNTSSVASTSSNVSISQIVRPGLGDRMFTNLDGGVKLTSITGSPPDESKGNTSHQRTASWDSLFDATQAQMVQDSIFDVSRSKMVDDSLFGGQDSQRDSFLSSGDSSRMSADADSLFGPGQSSSNKNFVLRGLRPVSTISTDTSNSAVDDTFADSGNVAKKIEEYERCLQAEGEDVSNMTPLGKRMAQPINGRQMLGSSMSRPAKPNRRRPHQLVFSDVPMDTPGLTSPSASESSSRVSLDTNAASLILGGARARGHCRQASSAQVNVGATIHEVPSIATLRPKKASNSPEHTRRSVLSQHEPTIMGVDMLESDNEIDRVDSVRSWVQWEREAIDEFRKTKNIWRDSEESKMAISDWKMPQTSDEIAAFLAQSSQAYKPLEQEQLPPGRTAHRRKSSLQDARSMCSPYGLPLPRPAPVNKPKMSLTTKYEKKSSTGSKASTAPSAFSFAFFPDDVPEAPSTAPLPTTAQVTSPLASVFAPFARETPASPPPTLAPFKPVSPFQLPTLDAFGLRKCLEDKTGKVNVQKEEVKKEADGEKRKRVDSKARRQALGWGRRRDSDGPDKVVAIGHAKMASEVPKKPTLFKPLQNKASVEKKAKGGKDKENSFRGEKSRIFTVKGQDSAINRPQPPKAQAGNRSPTKRKPAPRYVASQPTGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ72</accession>
    <name>A0A1E3IQ72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029855.1">
        <property type="nucleotide sequence ID" value="XM_019178136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195281"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129880" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="374"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="481"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="591"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="698"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="807"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="908"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1319"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1660"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1789" mass="184840" checksum="429FA1A0D0C25C14" modified="2017-01-18" version="1">MLVQILYLLAALFLSSVVHAGDSAWHLDNIWSLVNEELDPIISPNAQSSHMHAIVGGSKMAAYYNYADYAAAKCSSLEVQADKSNYWMPQLYVVDHDLSEFVPVSAKVRFYYFLAKNSDNDPVSAFPKGLRLVVGNPNNKAVTDVASFTCQINSDFSDSVVANDFNFDRDCPYGMKTELYFPPCWDGYNLYKSDGSHMSYPSNGVRDGMCPWSHPIRLPAIQLEYTWYTSNYNPGTALSGNLAWANGDTTGYGVHGDFINGWDLDVLNAALNDTSCNNIGNTMSDCPTLYKYFDATAAAACTPEKGTLTEPTGNANNVAIDALPGCNPLWSSGTKPTCSPAVAGLDASAFTGTDGSLIAATEDQKKFVWPTTPGFKNIACLHDISSVVGGTSYTDSYLTVESCTAHCLASGYQFAGTGQVGTGWNCVCGTGISSSALVEPGMCTTACPGNSTENCGGSYIFSIWYAPNGTVADIGKDRDDGSKYLGCYDDPSTVSDGLLGKATYSFSSNSMTTEVCIEACAQQGTSWAATLSAKNCYCGDEYYYGTGALMPTRYCSVACAGNSSEYCGDYYKSSLYNITSVKVTNSSAGYMEGYQGCYQDKSGHLALTNNSWTSTAMTAAQCVNGCSELGYSYAGVESGNTCYCGSKVSSTVTVLPASQCQTACTGNTTATCGGTQALDLYTVEGAVNTTTSLAAARPTGYLGCFKDMGSNLAFSNYYTYTFKSMTVEICKAACVELGYSYAGVENANQCNCGNNYPQTSQMVSGLYCTKSCAGNSSETCGAGGYLEAYTLSNSSSSSTSVMAGTSSSAYVGCYDNSNRGLAAYSYADSGMTVEVCRTTCAEFGYSLSGVYLGRYCGCGNSWTGATQKYPSSSCQNYACSGNSTEWCGGLTQLAMYNTSGVSTSHKKPTGWLSCWTDSSSSRSLTSYSYSASPMSAKACRTACNQQGYAYAGTENGNQCHCGNTLAGEKAPTSQCKMTCTGTTANETCGASGYMDLYNATGASSDNGISGYLGCYTDDTKLTGNSFVSDYMSVEVCAQWCLARGTTYAGVRNGNQCKCGNTSPSLVTTLAACNTSCTATGATSEPCGSSSAIGVYTIADTTVTSGEFPITTNSSGYAGCYKEGSTRMLPSYSFSSNSMTNDLCRSSCKTLGYAYAGSQYATQCYCAASLNATAGGYQIQESNCAMDCKGGVGKCGAGGVLSLWTTSGLNSSTATVEGLQGCYAIGSFLRSPGLTYSGDYMTTDLCRRTCRFGGWSIAGLTNGNGCYCSSTANYGSQVAPAVCNAACKGQTNQTCGATSSGAFSIFDTTGAGAQPPSGYPDDYVGCMSDGSPRKLSDYSFKNGGMTSAMVRKLAIAGGYPSYGTESSNEGYMGYSKLSPPLLPDTYCTSMCPGAPTERCGGGGRLSYYYMASVSNTTDTSTSAAATSTSVSANATSTSPVSTTVNVSVSTSASSSASSSRVSSNAGSSSAGTTSAPSSSSNSTSTGYLSAVSTSAIVSIGTPSTSSMPSVSANYSVSTVPAQSTTTSTPVGPSLFASNSSVSTIAPALSTSPVANTSSVTSSRSSSAVSSSVSANASTSAFSSIVASSIAPYSSASPTNTSSAVSSTAASSSASTQAPSSATSSSSSSTVYSTVYSTVTVSIGTSSSTPSSTSSYTAPSATGTSLGCYTGSSSSFANSKMTSHENLTPSMCQIWCNANYYTYAGLSGGNSCGCASDLSGLTNSTASSCSTSCSGDSSQSCGGTADSVYSIYQAVAATRSQKRSESVEPAKRRTAVHGRRVINRMANRAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQE0</accession>
    <name>A0A1E3IQE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029904.1">
        <property type="nucleotide sequence ID" value="XM_019178185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQE0"/>
    <dbReference type="GeneID" id="30195331"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="135" mass="14205" checksum="005535D655847DDE" modified="2017-01-18" version="1">MTLYIQQSKKAGFAGYVGKKAGITGQLTLKGGEVLHAVQDAGVPFRSIAEAVAGRLGIPTKSLILEEAAVHYYAFPCRDVLCARYGGFERAYERVVGLAAGAEGVGARISRLASGALVQRPCPSIESMESSMALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQI5</accession>
    <name>A0A1E3IQI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029718.1">
        <property type="nucleotide sequence ID" value="XM_019178280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQI5"/>
    <dbReference type="GeneID" id="30195426"/>
    <dbReference type="OrthoDB" id="10460279at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="223" mass="25128" checksum="D123981780D696AD" modified="2017-01-18" version="1">MPFPFHPEAFALLIATLAEDLPAYRFLQNFAAHHRFPPLPVFDTLTYAGPRGAHAFQHLAARHTCTPEGHVDRRQFRAANLDSTRWFPDDLPFMNPVYPAGPVHNPDVLNHPAILNSDLKVNSSSSRRSNGDPSRAAPGPVCLPVIHELVEHLTALRDARILRCLLVQILEKRHHMLDDSQNHHRPHRGSRHNQVIQYDEEGARPSVVGSEAGDEEEEDEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISX6</accession>
    <name>A0A1E3ISX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin 11C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029913.1">
        <property type="nucleotide sequence ID" value="XM_019178194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISX6"/>
    <dbReference type="GeneID" id="30195340"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34005" checksum="E5A3B0DB03EED82D" modified="2017-01-18" version="1">MSASKPSRSILNDPKHLLARLTRLESTIPGLDATLMLAQYSSPLIIALLLKLASIRARHPKVKLSQAAGQGVLKVDGGYGLVQLAEGWGRAGGSIGDARVIMRAFGMLPVLQSLLALHPKPLTSLLTLLSPDGLAKALQSPKAISTLQCLAILAYYPLEHVSWLATKGIISMSPQKVGKATLWSVRFWALYVALKVYELQKTYLALSSRTRALQHSKPDVSPTEAEGFKVQDEKTGPKDIQGKVEEKVSQAKVLGKEWLTWRNATISNAGYAPLTIHWSTPGGIWGSPLITGTMGSVAAVGSLLAEWHKGDIEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU52</accession>
    <name>A0A1E3IU52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030052.1">
        <property type="nucleotide sequence ID" value="XM_019178013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU52"/>
    <dbReference type="GeneID" id="30195152"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="429"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="607" mass="65900" checksum="E6CD165E63AAC10A" modified="2017-01-18" version="1">MPPKSSSQNPPSYDNPYLASSSLANAGPAFPSTPTSSQMPYPHQSSIESGTTVLEPVEHRDDGYSPAQGVMSDYRGASGAYAPHDEARHGEQDVGLLSANQPNDGYSYGTPYEEDQEPYRDRIVTASPSLGPWDSASQRSLPHHPTAFPLPQANLVPLGGEGSQMNGHVNKKPSYSGLSYIDEDGEYYHSERMRPASTNMSLAKGTEDMEMGNVHPASSYGSDPYKNPYQESPYPYPPPPQDANLSGFANYTTPSNLYTLLLFPTGLDRLLAMVGIKTGAYPIEQAIERKRRGLGGQRIPVATWALTAAMLGVMIYEMVRNYQAMGTPIAIRPTFNYMIGPSAEVLINIGARFPPCMKNVSALPATFELACLNDTSSTPTTSCTIEEICGHGGFNGNTPDLVAFHPPNPHARRHHPLHPQHARPDHPAAQVEREMGTIPFLITYTLGGIYGFVLGGNFSRVGVPSVGASGALFATNACVLVDLVLHWKYEERPRLKAFLLFLEFGIGFAIGYIPNAVDGLAHLGGWAMGILCGIILYPSISETNRHKYIVWGCRVVALVLVIVAMVTTIKNFYTDDPNAACEWCKYLSCIPTSSNEHCTGTVRSSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU76</accession>
    <name>A0A1E3IU76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030281.1">
        <property type="nucleotide sequence ID" value="XM_019177897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU76"/>
    <dbReference type="GeneID" id="30195032"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="348" mass="38242" checksum="0F5B5C2B8A181524" modified="2017-01-18" version="1">MSRLSLARFTLPLSRTLPRLMHTDGRQVDHSSAPAPHQPPPSPLTVAPLPNPDPAAINTPVTAPSTTPSAPRLTRRGTPIPTRPARKIPTTLPNGDLEPPFYPPPPEYFVEREERDTALLGKAGPVHPLWKFFHVPVANRLEEGANWPNSTGSLEELKQDDMSLHSGRAWSAAELRQKSFQDLHTLWYILVRERNVLATQNAERKRLGIGHHAEGIFNTKRAFRCRKTMARIKYVLNERRLGLVATAGPHLPDAPRVPWSSSPTTDPAGSTDAIRGVQPLSPRLAAFLRDYPSVGGGNAVAEESSFVEDGEVAEEEVEARDEGFGGGEEAKEFDAETVVNDGKVEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWF9</accession>
    <name>A0A1E3IWF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl-CoA-dependent ceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030392.1">
        <property type="nucleotide sequence ID" value="XM_019177641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWF9"/>
    <dbReference type="GeneID" id="30194772"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="137"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="45509" checksum="790C5B20F01C8EF5" modified="2017-01-18" version="1">MNDPLEVKPLSSRPRPAQNGKKDELPDLYHSGGFWNDLKKGKWMLIPSSSFKLMLIAPFLYYQHEILQHFGVFDSALPNVFEHFVFISNKLPDGRYGKSWWDFAFLANYIIFWSFVRQFMTLSVLRPMAKSLGIKGNKIMRFTEQGYAFFYFGILGTLGVYVMSSLPIWWYQTEHFWLEYPHRQMTWELKTYYLMQAAYWLQQTILLAGKIEKPRKDFKELVAHHVVTLWLVGWSYNIYLTYIGVAVFVTMDVSDIFLALAKCVNYVSDFWSVPVFAWFIGVWSYFRHYLNIIILYSVWAQFELIPWKERQGFDPLNDTFMVGWMKWQIFVPIFLLQLINLFWYFLIWRILFRTIFGEQLKDERSDDEDGEEEEVREKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXY0</accession>
    <name>A0A1E3IXY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030559.1">
        <property type="nucleotide sequence ID" value="XM_019177406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXY0"/>
    <dbReference type="GeneID" id="30194532"/>
    <dbReference type="OrthoDB" id="2571901at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="23797" checksum="E6AD71D5970D2ED5" modified="2017-01-18" version="1">MLPSLRAARPLSALALPHPDLAAANGHTRFALRAFEAIPSLAHAYAILRAAENKLGAKALHVRIPKSMDSLKLGPSIYIETLRPVKLEKQLLLEIPSPILSPESNFLGGLCLEDVAKSLDSDPVISTSVQRSPSNGRKDRPLQFKIEAAQPPSRNPSKARRSVEFRSKQGGKEGAEIVQALKAFEGGFYGGFEGVADKFEAMVAAHTKPRQGNGETASGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXZ0</accession>
    <name>A0A1E3IXZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030569.1">
        <property type="nucleotide sequence ID" value="XM_019177416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXZ0"/>
    <dbReference type="GeneID" id="30194542"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000010">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="38873" checksum="8EAAC11D66160037" modified="2017-01-18" version="1">MHGVKRTRLTSQAAAAKRAKEQVKVDAYLALQKEVLELKQAGDYSEGALGKTNQLLDLNPEFYTIWNYRRDILLALFPSLTPEDIVMYLANDLRLTTSYLLVHPKVYWIWTHRKWCLQSVPEGPGDSHEWRKKFWDGEMKLVEKMLDADARNFHAWSYRKYVLESLPTKRPLSAELNYTQSKIESNFSNFSAWHYRTKTLTAMWEGTSATEDEINKTKDEEFELVAQALWTDPGDQSGWLYHRWLVGPTPPKEVLKRELKNIQDLFEAEPDSKWCINALAHYTLLLAQQPSTSDEEAIGIRQEAEALYEKLIDVDSDRKERYRDMAASCVEGCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY93</accession>
    <name>A0A1E3IY93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory subunit for Cdc7 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030500.1">
        <property type="nucleotide sequence ID" value="XM_019177347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY93"/>
    <dbReference type="GeneID" id="30194470"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000094">
        <property type="entry name" value="Regulatory subunit for Cdc7p protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="518"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="622" mass="69066" checksum="EC54DDB3CC780468" modified="2017-01-18" version="1">MSVLSTNDARQQPRHRVLSGKEESGDIFSQWRKGINPVASKASTPNRQVLATVTNHHSTTNKRAQSPEAKKKVVAKDDASKPLATSQKRQAPATGGTPVAAKRTKLNNERDGVSASNGKVSKADEDKWTRSWVKAFPTLIFYFEIGAEEGPGKTLRSRVIKMGAKVEQFFSTRVTHCIVKESGSPQKQTKPLSQARNSDNARNPFLESGGTTDLAHKAAELHMKVWSVKKLSDILSRVAPVESPVVNNNSLSTLLEDERIHGTRERDATAPRPDHYYFKPGNKHLLIEDATSKHRTIMVKEYTYNARDGPEWPCLYGTFLRISSANQGSVPPSKLRERAWRLYAERQPYGGEQPRDLQRSTSLRALSSTARLPDLPDANAYQDASGNSVVITSNIASTSTPNTPILAGGMPTLGSNKDRAIMQMSKRVQVLKGNARLAAARVPKESSFSSLGTSAPTSLDRRRSMSQTIDTPKAFLSQDQVIRMLRQAREPVDEEAVSVADRMANRQKVEMGLKGRDQDSAAGYCENCRLKYSDLSVHIASKKHRRFAQNDENFASIDRLLCSLQRPMHPDRVQMMCPPCNEQHTQDWDCELCNVPPPLPDSENGYDSGLDFDESADRLMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYA3</accession>
    <name>A0A1E3IYA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030510.1">
        <property type="nucleotide sequence ID" value="XM_019177357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYA3"/>
    <dbReference type="GeneID" id="30194482"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="220"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="47024" checksum="113B8CD626267C28" modified="2017-01-18" version="1">MSEYLLAINCGSSSIKGKLFQVPQFDLLAHLAVSNISSADEKVKINIDWEEGKGKSSEEEGEYGDRVHYASLVPTLLDHLTDTSNESHLKKETIKYVCHRVVHGGTHEKGIRVSKGHEDGLKDMDTLSEFAPLHNHRAVLAVKSCLDALPDHTSLLLFDTIFHQTIPEEAYTYALPPPDKPLGMPLRKYGFHGLSYASIVNSLSKHLNKPEDKVNIVVAHLGSGASACCIKDGKSIDTSMGLTPLEGLIGGTRSGTIDPTAIFHHTSDAGAAANVGDYQVSRAEVVLNKKSGLQALAGTTNFGHIIQNLDPSSASSEEDHKKAILAYGVYLDRLLNYVSQYLFKLLSTTPLEEIDGIVFSGGIGEKGAKLREDVLKRFEWLGVEVDAKKNEAKEGGTVREITAEKSKLQGWVVETDEEGWMVKMAKDEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J008</accession>
    <name>A0A1E3J008_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030705.1">
        <property type="nucleotide sequence ID" value="XM_019177124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J008"/>
    <dbReference type="GeneID" id="30194238"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="192" mass="21093" checksum="382427940734A1D1" modified="2017-01-18" version="1">MELNGGSVVAMIGKDCVAIASDLRLGNQQVGIASNFDKVSPVNDKLYYGIPGLASDVYTLREHMRFRVNMYRMKEEREITPKTFTHLLSSTLYEKRFGPFFIEPVVAGLPSPTPLEPNPKPYISTMDTIGCITTPKDFAVAGTAADKLYGIAEGLWEPDLEPEDLFETISQALLSSVDRDALSGWGAVVNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J039</accession>
    <name>A0A1E3J039_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030735.1">
        <property type="nucleotide sequence ID" value="XM_019177154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J039"/>
    <dbReference type="GeneID" id="30194269"/>
    <dbReference type="OrthoDB" id="10293723at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15293" checksum="4A0EE02E508FF65F" modified="2017-01-18" version="1">MVAAYGRGGHPGIIGLDDFGSWMEDNFNIFATLHRDNVLEPATIDCALDACRDMLAVHTLPPDSWIQWVALIRHHINPFTRYFDYPYDVQHLIEDGNSNAQASTGIYEDEYGRYGGGRSPSPDSDMPSIIRAYYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J060</accession>
    <name>A0A1E3J060_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030801.1">
        <property type="nucleotide sequence ID" value="XM_019177220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J060"/>
    <dbReference type="GeneID" id="30194339"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="424"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="899" mass="99477" checksum="9A71D102FC9980E5" modified="2017-01-18" version="1">MAENLTDKSSEVLKAALDKAEELANAQVHPLHLISVLWEEPSQSSTAPDQPTLLKAAVEHVGGNPTLFNRALMGKINRLPVVDPAPSPPLPLANSFHAVLREAQKLQKDMNDGFVAIDHLLLALLHVDGSEMKELLKGTGAEIKALEAEIKRKRGGRKVDSKSAESQFDALNKYCVDLTALAEQGKLDPVIGRDNEIRRTIRILSRRTKGNPVLIGEPGVGKTAIAEGLAQRIVDRDVPASLISRLMALDMGALMAGAKYKGEYEERVKAVLSEVEKSGDEGTQIILFIDEIHLIMAGKDSSGGMDAANLLKPMLARGKLKVIGATTLNEYRQYIEKDSAFERRFAQVIVDEPSVPDTVAIMRGIREKYESHHGVRIMDSAIVLAAQLAKQYLTARRLPDSAIDLLDEAASAVKVARETRPEALDELERKKLGLEVEVHALEREKDEASKERLEAAKKAIADVEDQLGPLKREYENEKHIGDQIHELRRRIDELRAKADEAERRYDLATAADIRYHSIPQREEKLKELEQKEAEKGSGQGVTPDGIAEVVARWTGVPVSRLVETEKAKLLRLEKLISKQVIGQPEAVKSVANAIRLSRSGLGNQNRPIASFLLVGPSGTGKTLLAKTVASVMFNSEDAMVRIDASEYSEKHSISRLVGAPPGYVGHESGGALSEAVRRKPYSLILIDEIEKAAREFHQIFLQVLDDGRLTDGQGRTVDFRNTIIMMTSNVGSNFLNENPSEGPVQPEVRTQVNGAIAKTFPPEFINRIDDIILYRSLSRADIKKVVGVRLQEIQKRILDNNKKIKLDVDDSAREWLAQAGYSPSYGARPMARLIQTEILNPLSRLLLQARVRENETAHITADLRKNRLVVIPNHEPDVTMPDDSDEEDDSMDIEVEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0F5</accession>
    <name>A0A1E3J0F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030823.1">
        <property type="nucleotide sequence ID" value="XM_019177242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0F5"/>
    <dbReference type="GeneID" id="30194361"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="201"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="588"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="939" mass="104678" checksum="2CD21C69BA3C57C9" modified="2017-01-18" version="1">MPEPRPSSAASTVPFTPKPRKRTSSSRLAFTDRELREFAGTMASVRKVRPGSILEELEHSGEGSGILSRPSSSKTHTNHSERHPRPSSARETEYDRPQLQARPSSSASTRDVRRAHGREREYNPSSLGRAQSTRMSQSTLPTPNEAQERERQRESGKGKERQRVADPVPESETQMSNLAIAEEERLLDGVPLEVQEAWICEDLLFVLQGIEGTLIRFDETYDPLDAEQRLQGAKWTVHPDLDPSLVSLVNRLLPLASFFTAVDTSMESRATQEFGMVSHALCSGIRAMLKEYHVLTAQLESLFLSSPTFTLQTLYFHLHPTLRTMSLLASLCQSFETEDTGQESVDLSDDDDGLGGMADELGLGGAGLKGLMKNLKAQEGLIGGGGEVIGGEVLGIICERESTMSGDPTASTLYSTLLLHASQPYCRLLVQWISTGHLSDPFDEFMVKESGYITKGVLESDYTDEYWERRYTLRDGSSIGSGKISTGKATPSFSAAAPPPRQGTGRLPGGACIPAFLQPWKHKILLAGKYLNVIRECGIEVKKPGEVRHHPTTRDLVLTHYRFYKQIEDAYIYANKTLLKLMVDEQELIPHLRSMKHFFFLNQSDFLTNFLDLAGSELRKPAKSASIVKLQSLLDLAVRNPASSSSNDPYKDDLKVVMQSQGLYDWLLKIVSKTGSLGDGGELDFAMGDDDEAGSKRDEKRPLIGESYTVPSIDALAFDYSVKFPLSLVISRKTIARYQLIFRFLLHLHHLESSLSAMWLEHKAPAWRNNSGNDDIERWKMRIFSLRTRMAAFVRQVLAFATGEVLDPNWKALEEKLAKVQTVDQLLRDHVDFLDTCLKQCMLTTSKLLGIYAKLMTTISVFVSYQTSLNSALTKFLADPVAESGSVKSDSRWSALTRFEINFNHHAKLHLDAVTYNAGSENVALLALVTRLHQITLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N8</accession>
    <name>A0A1E3J1N8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031023.1">
        <property type="nucleotide sequence ID" value="XM_019176991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N8"/>
    <dbReference type="GeneID" id="30194101"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="940"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116803" checksum="F40D54C901348D36" modified="2017-01-18" version="1">MMVALPASPIDDNADARPATPRPLPPPPSPPLPRTTTHARSDSFPQTAGLTSPEWAEVDALPQRPSAKRNSSAYLRKLELGAAREKERFGLDDIRISTSPSYEEEIYIQLSPRSAHARLDDEAKNDQSPAMPSTSLPNSPPQGLHRQPSPSTPHVNVPTTARMRHPAPPSPLSQVLPTERGTSGAAAPTPKRDQLGTPSLAGLNIPEASPCFIHSHLDRHGSLQDWLKNKTGKDSGQAVAGTSAAHRHASNATHPVPQSSQAPPVPHSHAPPSPSPSGSHSHDTKGKAAVLPASRKEVTSSEYESESDTTRDHRKTDIGLANGLPGYDEDQEIDEEGNASLTKQLAETARGVREMSKELGRTKVRSRIQHVLIVTKARDNRLIKLTRELALYLMHKRPATSPDRNGASTSGSSRGERRDRGMVVYVDAQLRNSKRFDADGLQRDYPQLFEPMARRRSSSASLSTFSALSSAHPSTTSMRDAARQASNEEGQLRYWTSDLCSESPHLFDFVITLGGDGTVLFTSWLFQKIVPPVLPFALGSLGFLTNFDFYNYKDIMDRVVDEGIRVNLRMRFTCTVYRAIAPEENATAKGKKRKAIKKPGGEILMSRVDKGGWESLEGPTPSGPPLDMEEEGEDKEIMCYSTRPVEQFEVLNDLVVDRGPSPYVSLLELFGDEHHLTTVQADGLTVSTPTGSTAYSLSAGGSLVHPQIPAILITPICPHTLSFRPMLLPDSMELRVCVPYNSRSTAWASFDGRGRVELKQGDHIKVTASKYPFPTVCADKASTDWFSSISRTLRWNEREKQKSFVVVEEDSEPPKYKTADGKEDSKKKVFDEKKAKTKFEGDAKGKGSEIVDAGNEEDDEDEDEDEDESFDIDDSVSGPSSPPHEHAQEPQVPPQQLHNLLNSHQNGLEIPNRFVTPYSAPPAISQRHLVEALHKAEIKAKDNEVGQRDNIRGDPSDMRVDGHHHLIPPGRSRLNSPTESTDASDTTQMDEKIREEKTPRPHNGHDHHHHHHHHHHHHRPGEHSAPNSLAERVAECKAKAFAFFGQDDSASECSDDHSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1X0</accession>
    <name>A0A1E3J1X0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031128.1">
        <property type="nucleotide sequence ID" value="XM_019177096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1X0"/>
    <dbReference type="GeneID" id="30194210"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="259" mass="28182" checksum="554B77B6F02D0246" modified="2017-01-18" version="1">MVTPISLEYTLDRASDLFENISGVQQDVDIAAGDGPKPRLVAVSKLKPASDIQALYDVGFRHFGENYIQEMVDKSQVLPSDIKWHFIGALQSNKSKLAASVENLYILETLSSHKVADLLQKSIPPSRKMPLNVYLQVNTSGEDAKSGLAPLPSSNHETVDLAVHVITKCPSLKVLGLMTIGSWEASHDPSKPNPDFECLKATRKELAKILAEKGVEGAPREDELELSMGMSADFAVAVKEGSSSVRVGTRIFGDRPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V7</accession>
    <name>A0A1E3J2V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031168.1">
        <property type="nucleotide sequence ID" value="XM_019176693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V7"/>
    <dbReference type="GeneID" id="30193788"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="40263" checksum="A574B7766D6523CF" modified="2017-01-18" version="1">MSEVTPQRFDPKNMIYRNLGSTGLRVPVFSYGGWLTVGYNQKGDIVKELMQTAFDSGINMFDNAEIYAAGESESQMGRVIKELGWDRSDIIVTTKVFFGTGDAEKHNTRGLSRKHIVEGVNKSLARLGLDYVDIIFAHRPDVTTPIEETVRAFNYLIDNGKAFYWGTSEWSAHQIQQAIEIAKRLNMVGPAAEQPHYSMLHRERFEVEYEPLWRYERFGSTIWSPLDSGMLTGKYNNGIPKDSRYHHNLGNVMDSSIKALETPEGKAKIEKVKKLTEIAERLGGSMTSLALAWTLLHEGVSSCILGATKPEQIKENVKALDIFPKLTPEIAAEIEKILDNKPAPPPAYNRRADDGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3E2</accession>
    <name>A0A1E3J3E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031165.1">
        <property type="nucleotide sequence ID" value="XM_019176690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3E2"/>
    <dbReference type="GeneID" id="30193785"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="237"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="880" mass="94781" checksum="20ADADF604B6429F" modified="2017-01-18" version="1">MLGHDDADEGDISLAFTSNPASRAAAAPARPLAPASDFEQDVAVPSPRPLLDKESASNPGQRTRSRQGVTVSLNDEDGATSTATAPGHWAPGALKSGSRPSPAQPLSPQSYPNVDTSRIPFSTQPPGLPRRASSGLGRSRSLNVRLPSADDSSSSDPAQNSKQAPMSASSSRPTPSSRIGWSRRPGEPRPPPMMSPEVAEKMGRWVKDVVVCNFDLDRGPVVERKAGSRRWGFGEKENVAFSSFPDTSLFAEGTVLFSFKIRHIPPDPESLSLPEPPSPMPDRTKTVEEELLNDKLNTEGAASASHPATMSTGEKADEYRKWDERGREWLYGFVWFEQRQDQGIRRGYMQQKSLVILTHLPFPALFASVLQRVAPAFFDYGYSALEAACHSIAKWPDPIPDTLLSLPFMSDVLNVKLPDTSESTQMFKVTSIPSTPSPSHAPILASLPTSTPLRTFAPFIASLWSLWECLVLSEPILIIAPDPKTCSEIVWWLRDLMRPLPPAGDFRPYLHIHDHDFSLLVNANKPQPGVVVGVTNPFFRNAASHWPNVISIPSKSRKIRPSSSSSYSNPLDGPEGFITRRHRSVQKDRPLLKRLEALVAEGNLDDPAGNEALRSHFQQLTERFMVPLNRYFQTLVPTQTPIPGMGSHLTPSMAGSPHPSANNLPSPSPSPSLSASPMPSPAVFSHLSPSLPVPLSSQSPLTAIRPFSLPAFLTHLRNSGPNPLLFRSKSIILTGKSRVENDFYASFCMSAGFAGWLGGRVESLGGALAGSVSRTGTPRPSTSSSRSVSSSGLTVPSTPNRRSPAPGPPSRLRSVSSTLITTTSAELDSESARVTPEAGLGARPAFSRSASVGLGISGGGSGLSNMDKEEGRKESSEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3I7</accession>
    <name>A0A1E3J3I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031205.1">
        <property type="nucleotide sequence ID" value="XM_019176730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3I7"/>
    <dbReference type="GeneID" id="30193826"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="242" mass="27160" checksum="FA806EC543D6FAE1" modified="2017-01-18" version="1">MATLRIRTSNTTPPNVLAPNLPLSSSLFNGQPYKIVLLPASALTTGTRAVLFRILDQNMKTIQDNSSFPYTEESKQEEMFDPTSRFLLALESSASVPALEGKRPEEMSSVAELTEEDVLGFVEWRFDTEETLRGSDVEVAYLYEIQLTSSSKGLGIGRHLMEILEEIGDRRQMQKVMLTCLKTNPKALQFYAKLGYEADEIDPTRMAEEDSESDGDSNDSDDEDEEVVDYVILSKALSRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4C1</accession>
    <name>A0A1E3J4C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031385.1">
        <property type="nucleotide sequence ID" value="XM_019176457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4C1"/>
    <dbReference type="GeneID" id="30193551"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15601" checksum="94501528A283473A" modified="2017-01-18" version="1">MSSAAYRRDSSATKNKRVITDSNVPLDDELRGIKLDIPFRNALKFFARLSEAVFHEAFDTIYWALNSRRSREHRTFWVNGPRDYVGINARDPLEEGFAFWELNKTPRPPAKCDLCDRLFSQEKYLYIHVRTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5Q7</accession>
    <name>A0A1E3J5Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031261.1">
        <property type="nucleotide sequence ID" value="XM_019176786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5Q7"/>
    <dbReference type="GeneID" id="30193885"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="418"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="643"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="81484" checksum="A60C0B927D317B5F" modified="2017-01-18" version="1">MPFTNVPFYTPKPAKSSNATMNIPMTLGLIPQYMVWHSLTGSANGVTETAPVVPTDRNLSPTVTISEQTEQPQSPNELQPPRASATLLQSPSSPKSTQTPGTPQIRSRPRAASTLSVASTTASRPPSFISEDEDDQGDSSSDDSMLSWWSDDSSDDEEAEGEETSEKVENGQGNDTTPKAKKTRRSAPKPPTNPEKEAERKRREAQRHSLLAAAGLQVTREPSVRRAAPAVPGGRKRRHAPAVPEGRRRGKDLPPIPDEQYEKSERLGTQDAYARYEAFLAQSAQAQSQPLPRPESLSVQSRPSSQGLSPQTTGQSPQGAPLSPTSTITSLPPSIGKEAGGKISGFFKSVLATHHPEPKRPSISGPTISRVGIDDQPSSPSPGSTGQSSEAESSEFGKTWSSLVEPSVLNTMDKSERKRQEAIFEFIATENAYNRDLQLIVEASDMLVFYASLLSMLDEKALTVIFANIEDILLFNTGFFSALEERQKAARLYVVKIGDVLSFLNEAGIYMTYCINQHQAIKLLQSLREERPELNAHLQHIRETNASIRGLDLSSFLLIPMQRITRYPLLIKQIIAYTPYDHSDLPQLEQALRVTEGIVSRINESVRESEGQERLRTLSENLWIGGEGRLDLTAPTAFSGPRRLVKEGTVTKAKSGRKLTMLLCNDIIVLLDNKDLYRMPLALHEVEVKQTRDVTGFALRADQRRGGDTVALKVMSASDAKDWMGKIDRARKQALSARRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6A7</accession>
    <name>A0A1E3J6A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031645.1">
        <property type="nucleotide sequence ID" value="XM_019176235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6A7"/>
    <dbReference type="GeneID" id="30193326"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="36"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="69536" checksum="8D9C03C7FF41BA8A" modified="2017-01-18" version="1">MATIPPPYSSRDHAQVQPGPHSITTSPTQEFSESTAVTLEWTITGAKAMYEATRGEQKSKCVKSAVFGDVDNCWELLFYANSGQSAQAGDHVSLYLSCVPTPQERGSKLAHQWHRKGLWWFKFEIRSGHPKPEPIVTKEASDHTFAVKIANWGWVSYLKRDALFLHPQVLASDTFQILCTIRAQPQPPAGFWLGVGLQPSSPVKADGRGEGSGGGLSRWASQSGCAGVAGGTTAGGGSRRVVPKELVMGLGNMLDDPLYSDVEFIIPSRDGPPKKIYAIKKLLCRYDYFEALLNGGFGEDEGLVDEEIVVDDDLDMLSDSDIGDEHDPYGDEEPEDEEALFPHLNPTTASQRSTSPPQPAHNQSTSSDVINNCQEKVDDLKDTMATIPGGLGQSLKDHKLQDDLQEDEHREENQEVRSKPLPKADVAGPKKTIVIIRDAAWTTWWALLYWLYTDIIYFAPLTSTFENSHKPCTPTSATTTTDEPTNRLEWLRRWMADHHIDLPPSSSSTFGEPSYEVHAGPRPVSSKSIYRLADKMDILPLKLRAYHHICSQLTANNVPAEVFSRFSATFEDVRKVQVECFLANWGEIKKSDVMMDIWKNIRLGKHAGFEEVWPLIVKQLDFKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6M3</accession>
    <name>A0A1E3J6M3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031738.1">
        <property type="nucleotide sequence ID" value="XM_019176328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6M3"/>
    <dbReference type="GeneID" id="30193419"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="296"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="618" mass="67582" checksum="03842890EF8A3018" modified="2017-01-18" version="1">MPPPIIPSHSDLARQKLESTLANDLYSLSFSSIPTSTVSYDDPDESLEYPRGADDAVTYDNHDQHNNGVRRGDGMNGDGLSTYRGEASMFIGASPISTAGHHASAMTLGAGVFENGGDTSRTGEFDPERSLGRLVNELGKVMGNERMPERPTSPFYTNQSPTPVFNPLNLSFTLTRSNPLPSPPSSPVYQDHKPQAGQWQDTSLRDTRFARTPKAAGVHSSASQSKPTKSKSKASEKSNIKTPRAEGSSVRSVSAPVRGGRTMGDVTGLTDLLKTPARAGEYGYLNRDESVGGVALVDIPGNLEQLNERLKNLEVENTTSQRRMRELQDELSNAKEELAEAQKNGDRGVKEVADEKTALEQLVGSTQAHLSRLTLELDAHRAVIHKFQSAPPHPSFSPSSSTLANIRSEINRLSQQVSSLNSIVEKGLATCQHSRSERSVRMERQKMEKLVRQIVQDEQPAQQEAAPGPSKLRQGLRAAASIHETLAPATVQRPGPSKAERTFVRSEDMTYSPTPTLTRAPSAPSSRQPSGAGPHRVNKEPTGEIRESARVTLQRILGQAEEDYVHYKSIYVDLATRYKSLDPASDPRKRHIIAKKLKQAIGVLERKGDEVRDLRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6T6</accession>
    <name>A0A1E3J6T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031813.1">
        <property type="nucleotide sequence ID" value="XM_019176403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6T6"/>
    <dbReference type="GeneID" id="30193496"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="170"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="670" mass="76200" checksum="93EAA955714EB39F" modified="2017-01-18" version="1">MSSVAGLQRITPVPTSAEFIDVVLNSTMRKTPTVIHKNFKISRIRNFYMRKVKFTQDTFDEKLGKIVSEFPVLDNLHPFLSSLLNVLYDKNHYKLALGQINTARHLISQVSKDYCRLLKFGDSLYRCKQLKKAALGRMATIMKRQKDPLAYLEQVRQHISRLPAIDPNTRTLLICGYPNVGKSSFVNKITRADVDVQPYAFTTKSLFVGHMDYKYLRWQVIDTPGVLDHPLEEMNTIEMQSITALAHLRSAVMYFMDLSEQCGYTIEAQCKLFHSIKPLFQNKPTVLVINKIDIVRLDDLSPENRSYVDTILSDKSVIVVEASTYTEEGVINVRNTACDALLAHRVEVKLQGSRIEMVANKIHVAVPQKRDDVERKPFIPDAVKGRVKYDKENPDRQVLERDVEQELDHSGQGVYSVDMKKNYLLADDSWKYDVMPEIINGKNIADFIDADILEKLDALEREEEALENQGFYASDEEEMLDSEGEEFQDAARQIKAKKASIKKISQEKNHLQNRPIIPRKKKHVSLTEFTEGMRAAGHDPMVLEKRAARMIAKKKQAWEKAQAEDAAAAEEGGMDVEMDGGDVEMEVAPGDRKELKRRAALATTRAPRTNRLTGGVSTMGQHDKANELQAFAQRLPNRLAKASESDRHVPITRPKWMLSGKRKSGTNDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6V0</accession>
    <name>A0A1E3J6V0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031818.1">
        <property type="nucleotide sequence ID" value="XM_019176408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6V0"/>
    <dbReference type="GeneID" id="30193501"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="180" mass="19478" checksum="2C5AE9027C5637F9" modified="2017-01-18" version="1">MNPTRSLLSLSAAFARLAVRPTLPSIASLPSRAVAPSQSARLLRSERGFASSSRCEATINQVMRGARKSSKRKSSVPLLQDCFQKKAVCAKVYTTKPRKPNSAVRKVARVKLSNGMMTTAYIPGEGHNLQEHSVVLVRGGGAKDLPGVRYKIVRGTMDLNGVAGRISARSKYGVKKQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7D7</accession>
    <name>A0A1E3J7D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04469</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031516.1">
        <property type="nucleotide sequence ID" value="XM_019176588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7D7"/>
    <dbReference type="GeneID" id="30193682"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="601" mass="67950" checksum="F426994A01803434" modified="2017-01-18" version="1">MSEVRPRKGAQSKAAEQPGKKLSKEEINAKVGNVQLMGTVRLGLSCLGLLAVLWFSYKTLTPMLQSKPVAQSQTRLTGTQYGSIKTSDVPKLKAGGKLEADVQKREAIKEAFEWSWHPYERHAWGADEYQPLSQTGSNLTESGGVGYTIVDSLDSLLLMDLIPEYQRARDWVRDNLHFDRDSQFNTFETTIRVLGGLLSAHYMSSTHASPEIQADASLYLDLATDLGERLLGAFSSPSGIPWSGINLATRVGIPDKDNQGVASLAEAASLQLELKYLSHLTGDYIFWKKAEKVTEVIRNQAIFDGIAPIFINPVNGQFVASEIRLGSRGDSYYEYLLKQWLQTNRQEPVYRDMYDEAMGGIRKHLIGKTKKSNLIFTQELHPARHPRDQTQSWQVVPKQDHLVCFLGGSFLLGVTDGGKKEVDWEKLDKRDEEDFLIGQGIVESCMKTHETATGLAPEIAMFVQWSDDRASDLDWYIKPNQNGVLIDGRNILRPETVESLFLAYRVTGDQKYRDWGWKVFQAFNKWCRVEKGGYAGIEDVQAMPPKQLDRMETFWLGETLKYLYLLFDDSDHISLDKNIFNTEAHILPVFDSEYFSPFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8P0</accession>
    <name>A0A1E3J8P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031842.1">
        <property type="nucleotide sequence ID" value="XM_019175929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8P0"/>
    <dbReference type="GeneID" id="30193016"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="3">
        <location>
            <begin position="395"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="658" mass="71945" checksum="CC76E90E8B7C9601" modified="2017-01-18" version="1">MPPRAPIRCPPRTLLAPSSTPFRPNPPPGIAYRLRRPFASTTPATPSSSSDLRPATSPDDPPVPQVTVNGAEFAATELEDIKGLLDKELGGDPIWAERVQSALDDLSLQRRGRLAVIGDQAASPREVVSALLQDPLVDDAATRRAIVDRHQDANIEIFNLSLGARLHREPESLAVSSSWLQNSAYDILEIDVNRLDPESAISSVLSADAVVVSIDPIRLTSVPEIQRLLPFLLNHELVEFVVNGPLPSSVTQASVVTQLTKQLGDVADKALNALEFLAKGLELTSATPAMKTTAFESFQKDYLQSHIGPLQHALHQTLRAIPKPQLCTAQRLAKFALSHIEDAILQERDVVRQAVLTVSELRRTAENYAIRARHLSVTTKGVDGAVVEGEVKYEMERIKSRIESSFQDDLSWLGLLGRLKVDDVALELGGFVGSRLALDLERQIVFETGQLSQLQQSLSSSSDEILRQLAHPSRQRHISAATRGNPLSSPLLANHLSTLSLSIPTLTPAHLLSPILTRRNQLISQSIPRLQISAQRSLLTTYSTTILGVTGSWIGSVAPLELFSTSTAGGLGVLSVVASLALGQTLWARAQKRFWKDWDRITGMLKGDLETRLDTTLKTHILAKPLATAEGLERLITKRQDRLDDLQARATELRSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8S9</accession>
    <name>A0A1E3J8S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031871.1">
        <property type="nucleotide sequence ID" value="XM_019175958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8S9"/>
    <dbReference type="GeneID" id="30193045"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130264" description="asparaginase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="41200" checksum="9146A4EE3125A2BE" modified="2017-01-18" version="1">MLAKHLLLAAASAAAAIASPLLHIKRDDFGLEWMSKDGASPLPKIVLYDTGGTIVSASNYSRLDNINYGFGVNPTVQELISNYSEILNIAQIAFVKFPTSGGSSGLNSSTYFNVSKAANEHLCSPDSEITGAVLIGGTNTLEDTFFGVDLTLNCSKPFVTTGAMRPQTYISHDGPSNLYQAFAVAADPKAWNRGGLVVFNDRISSAFYTIKTDGNTVDTFKALEQGNLGTCLGGQPYWFFEPSYPVARGHFDLQAAGLTSGDELPSVVVLFGSQGFDASLMYAAVANGAKGIVIQGAGAGQLSPDAVAAATVLKEQGIPVVASLRPVTGASVPRPYAPSYISSGYMQAGKSRIQLQLCLAVGAGWDGCQEAFEKDMREAIYNRLTTYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J939</accession>
    <name>A0A1E3J939_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031697.1">
        <property type="nucleotide sequence ID" value="XM_019176287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J939"/>
    <dbReference type="GeneID" id="30193378"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="360" mass="39958" checksum="E001542ABBD05CBB" modified="2017-01-18" version="1">MPSIIPTIDLAHDSPARQAELIKLALGNVGFFRVVNAGPARQDVEKMFEYSPSSASPWPPKRHTSPDVQVPATPSSCPKLWARVNVITKSKTFSYGKYCADTTQQMPPPFQDSTPGGQEAHQTIKRFYKDCHQVSELLLELFALALQLERTHFKQSHSFGLNTAMSLIHYPALNEAEAKALSTIDIRAGEHKDWGSMTLLFQQPRGQPGLQVHLPSSLIRPDDPQASPESYEWYPAPIPEAHQDEHAGFLVNVGLGMELWSKGAYKATMHRVIFPGEEAGSESVQDRHTIGFFVQPDDHVAFQPILPGGKVDTSTKAITSGELFDMKLQESMERFQKHFAFSGGDEKVKKDVQVENAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J962</accession>
    <name>A0A1E3J962_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multifunctional methyltransferase subunit TRM112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with TRM9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031991.1">
        <property type="nucleotide sequence ID" value="XM_019176078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J962"/>
    <dbReference type="GeneID" id="30193166"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000018">
        <property type="entry name" value="Multifunctional methyltransferase subunit TRM112-like B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="124" mass="14289" checksum="5FA3C560BF586BD1" modified="2017-01-18" version="1">MVRLITHNMLQCHVKNCTKDNFPLVFSEVETLIREATFNPDFIQRFLPKLDWRALVDTARSLGDNSLPEQMPEEFSEEQLQALHYVLFELNVEEGNMTCRGCGHVYPISNGIPNMLLAEHEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J993</accession>
    <name>A0A1E3J993_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Template-activating factor I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032021.1">
        <property type="nucleotide sequence ID" value="XM_019176108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J993"/>
    <dbReference type="GeneID" id="30193196"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="30975" checksum="B70850D60C631A80" modified="2017-01-18" version="1">MSAAQDFQITAPQISESLRKELETKEGAKNVRLNRFQVKETLAYLDELRTKVKDIDSFWLIALMSHEAVAAHLTAKVDQHALSFLQDVELKQDVNDFRPFELVFHFKENPYFTNKSISKKYSLGPDTKPVTGEDVSEELTEFDEDSLVVEPTTIDWKPNQDLTAQFPRKMQGEAAGNGEADDLEDGFEGDPGTFFWYFVEKMDMFNFGFILKDDILPDAFAYFDGRGAANASDMIDSEDEDDEEDDEDDDEIDLENEKPKKKRKVCRDGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JB89</accession>
    <name>A0A1E3JB89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031978.1">
        <property type="nucleotide sequence ID" value="XM_019176065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JB89"/>
    <dbReference type="GeneID" id="30193153"/>
    <dbReference type="OrthoDB" id="2575884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="48597" checksum="32DD3EC19117101F" modified="2017-01-18" version="1">MAFTSNTPPSTTDIQIPEYLNPNTLFQPQEQNVTNTFLGHPKADGVTALAGAGQSDMASILLNTSRDAFKANMMQIDATSQLPVWQEESWDELLGESVMRPCRNRREGGAIHGSSTMASRYIDPQFLDIPRSPPSTAASPTSEHLLPEPFDVRSVLEDLDRQNDVFSQEGFTTMDIDSSGPILPGTVVGGRDNDRNEPHSQIDLASLFNRLDHAGPTLTLQDALKQSQLFVNFDDDVSNTSVHPENLALKRKAFEGSNHGVPDTKRRDMTFEVDNLLSLTAPLTMTPKALLANAPDSPLLQIALKSDSSSPDESTASVANVKASTARPKSVVPEKFIGDGSAETALGMSTAAIQSFPTFEELLKHVHPDNYARAKAFGERIAKNRLKAKNAAKRSRDQRRAKIEKAEELEKETEMLQGKLDGMRTLLSRLVANGTLSKDAVKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBW6</accession>
    <name>A0A1E3JBW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AFG3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_03588</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032206.1">
        <property type="nucleotide sequence ID" value="XM_019175716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBW6"/>
    <dbReference type="GeneID" id="30192801"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="360"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="768"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN98344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="812" mass="87393" checksum="3069418990EFFB44" modified="2017-01-18" version="1">MSLRAMALRRLPRYTPVRPLLARGYATPGSPKPSRNPPPPPGLESVFGGGKQGTTSAPKPPGVTIPGGPSLPKKPDVGLPGLEGEENRPEDQKDVDEPRKNRLSEQLSGKAGKKVGTGGGGGSGGGGAGGGPGGQPGGFGGMTPNQLLMVAISTYALWSMSSPDDVRSKEITWQEFRNSLLARGLVSSLEVVNRSKVRVHVHNPIGQNGVQQPNASGTSLPSPPHGPAPYQFTIGSLEAFENLLIRTQDELEIPPSERIPVSYREEISTFQTIMHFAPTLMIAGLLLWMARRGGGAMGGGGPGGGIFGVGKSRAKMFNKDEEVTVRFRDVAGMDEAKEEIMEFVKFLKEPQKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFLSVSGSEFVEMFVGVGPSRVRDLFANAKKNAPCIIFVDEIDAIGKSRGKGGNFGGNDERESTLNQLLVEMDGFGTNEHVVVLAGTNRADVLDSALMRPGRFDRHIAIDRPDIGGRRHIFGVHLKPITLEPGLPAERIAEKLALLTPGFSGADIANVCNEAALRAARHGGEFVTEADFDGAIERVIAGLERKSRVLGKEEKKTVAYHEAGHAVCGWYLEHADPLLKVSIIPRGVGALGYAQYLPKERFLFTTEQLIDRMAMTLGGRVSEEIFFGKITTGAQDDLQKITKMAFEICANYGMDSAIGPISYGGREQQGEGFQKPFSEATAEALDRAVKKLVMDAHTKTTQLLTEHKEDVEKVAQLLLQKEVITREDMRLTLGPRPFANKDEMDDLIERELDRKRSEKPKSESGPTPQLAFKPTKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCJ8</accession>
    <name>A0A1E3JCJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032277.1">
        <property type="nucleotide sequence ID" value="XM_019175787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCJ8"/>
    <dbReference type="GeneID" id="30192872"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN98415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="301" mass="32818" checksum="7DA77C35949C7F0E" modified="2017-01-18" version="1">MTPLFLNTPAQYAELVNSVDTVLFDCDGVLYLGENLIENAKNLLEMLRSSGKKVIFVTNNSTKSRKDLKKTFDGHGLEASIEECFGSAYASAVYLSEVLKFPKDKKVYVFGHEGLEEELDEVGISHCGGSDPEDRTFTPPLNYADYRPDPSVGAVLCGADHYINLKKITKAVTYLHNPECKLILTNPDATFPIGDGIFPASGAMSAGIVYAAKQTPVVIGKPSKTMMDAVVAHHHIDPARTLMIGDNLHTDIEFGINSGIRTLLVMTGVTTYDQIYGPNPSPVVPTYVIERAGDLVRMSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI65</accession>
    <name>A0A1E3JI65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032730.1">
        <property type="nucleotide sequence ID" value="XM_019174998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI65"/>
    <dbReference type="GeneID" id="30192070"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="16090" checksum="D6BECDBC0B9B3E69" modified="2017-01-18" version="1">MDHAIEQDLKLEELFANERRRNEEARKRAQMQASNPPSQPSTITIPANWKLRLTAALAYLAAFPAGHSWSFDKNRDFLRGMYEEVKVLYLLRESDALKISALVANLEIELMTFEGNPACGRRCVEAVELGIKHLKCIVNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL10</accession>
    <name>A0A1E3JL10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cardiolipin-specific phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032804.1">
        <property type="nucleotide sequence ID" value="XM_019175072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL10"/>
    <dbReference type="GeneID" id="30192145"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="180"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="527" mass="57668" checksum="A5FC0CFFA41B3504" modified="2017-01-18" version="1">MSSTPLPQSRDIPKDFRASLSAWWSSGSYKNSRLAEERLLRRLTMYEPKVEEAKVEGSKGWLGWGHGASSVTESQSATAQVASTVTLESSGSGSPAGLVASLRNVFIPTPDPEDAPLHPADPRTPLASLASSPASSSTSVDSHEKKHKHKCHKHRKDGELVDYINTLEISAPKDKNSKEAVVVLHGYAAALGFFFRNWESIATAASSTDRRAFFLDWLGMGLSSRPSPALLASPSTASTSSRVARAEHFFLSSLESWREEAGVDKMVLVGHSLGGYLASAYAVRYPERVSGLILVSPAGIPHGPEYVRQPLTAEVRSAASSRERVETPGDLDGAVNAAEMELGDQTKDSAPKGEAKAARERNEQSFSRRNMMKLFVWGWERGLSPFSILRGLGPWGPLWVGKYSSRRFAAQTEEDVRDLHNYIYETSVMKGSGEFCISHILAPGAYARIPILDRIARISAPVTFMFGDNDWMDVQGGYDSKKLLAEAGNEKCEVHVVPKAGHHLYLDNPEVSNRILREAIESAPRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLB6</accession>
    <name>A0A1E3JLB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear segregation protein Bfr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032914.1">
        <property type="nucleotide sequence ID" value="XM_019175182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLB6"/>
    <dbReference type="GeneID" id="30192261"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="546" mass="60240" checksum="F4D5736F7AEF816F" modified="2017-01-18" version="1">MPPPTATQKPTAPAPAKKDGEDKKSTQLTKPDQSKYNAEQDTINKEIAEVKTKLDAIRSRIALSQAPTSNDRRSAIKSELDSLRGEQAKFRGDRNKLFEDMKRLQESVQKKIKEVQGSRGKLVYRTVSEVDARIEELDGQVESGNLKLVDEKKALQEISNLKRSRRTLEANGSIDDSIAADKARIEDLKKQLDDPEAKKLSERFDELKKEMDGLREDSSKAYEERGKLFDERNALSAEMDELYNKKRQSAQKYRESNDKYYAKVQADRQARQERFKADKAREETERREEEIVRLREEAKIPAYASEIDDTGVLISWFKGKYGSGEVPSTHAGGKGVSNVVEGVKPLETRKVDDEAFKGMTLKKKGEDDLAGFFGGSGKSKKKGGKKGSTNGSGTATPVSQDGEKSGKEAAVNLPMSLLSALLSLGIPPPSGKDDVQRTVDDLEKKKAWFEANSAAKTKAEIERVEKVVAKLQKKNAVAVDEASAEISEKGGLHEPLHTVAVEGSASGPENVLDEGEQLPTNAGEASEVKKVDSKLEEAKETLESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH0</accession>
    <name>A0A1E3JRH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033522.1">
        <property type="nucleotide sequence ID" value="XM_019174470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH0"/>
    <dbReference type="GeneID" id="30191531"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF38">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="611"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="818" mass="86457" checksum="4FE7F0061F063082" modified="2017-01-18" version="1">MSTPHGASPSASYLHQDAELYSLDFLGLSELDAPMSDVDSPKPAAGLADSARRNQGHAVDAGQHVHGKSDVGETFQGGIHQNGGHTMEVDEGVMDGKKQEFMFNGHEYDALQAAMLQQQLSSFHMQSPLGFDINNPPFHLSQMLSSPARQALQLHNSHSQQTSHSAYDSSVSHAPYNTHSHRNSFSALPTKTPLEQLQDQQAQFQEQLALLQQQQLEMQATAAAVMAAQSSPYMLGHGPSPSSSRPSTTPGVTQSPGGIFSPLTSPALEATNRPHRSHSGHHNHQFSPAFNAQQQRTPHPLSTMSSPALNPVGSSGGANQTLSPALTAQNSADMDPEYVRALVGMLDSGHTPPSGEPLQPPYQSPSMASTSTAGHTTVISSPALHATGSGTGPHRQSLPSKTRPSPMLKPTNHRSNHRNSVSGHYSVPSSPAVTKYQPDASMPPAAMSSGLPPSALEHHRQVHSSTSTTSTPSPVDLSQIMPPPPVPAGSSKSRKGVMPMTPASLMNLGSGNESTDGGQSVPLPPPPKRVGNSSTGADGGQIAAEGSGGGQTAITEKGAKKQGGKKGNAGKPVPVGGKRALAARPQAVGVRVATKAAAAAAAAALSLEPENRKISHKAAEQKRRDSLKAGFDELRLLLPPINTEALDPLSGEPIPGSSAPRLLPKSSLVPDDNPNRGISKVALLRFGNEYIEKLQERVDRRDVFIEKLREEVERLRQGGQEEVRGEDGEDLLDYDWREGEDDEFGEDKDSDEEGEEGEEEEDVMDEGMEVEDDGSGLSKRPTRTKSLSARSPGIKATGLSLSRASGSDATTTRGKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRR1</accession>
    <name>A0A1E3JRR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033619.1">
        <property type="nucleotide sequence ID" value="XM_019174567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRR1"/>
    <dbReference type="GeneID" id="30191629"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="118" mass="12717" checksum="724E482360571084" modified="2017-01-18" version="1">MPLTETTYPPPDSAIDSSSSPVFLIFYSNVEGGSMWCPHCRDVQGVVKAAFTGGSKPRGVVTYVGNYTQWKTPSHPARGKYGVKSVPTIIKFQNGKETGRATKADILDSGKFEAFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRS0</accession>
    <name>A0A1E3JRS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033629.1">
        <property type="nucleotide sequence ID" value="XM_019174577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRS0"/>
    <dbReference type="GeneID" id="30191639"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130525" evidence="3">
        <location>
            <begin position="19"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="40389" checksum="A416752798012ADF" modified="2017-01-18" version="1">MSRLALLALASLAAVASAAKSGWGEACSQANTHLDQANYQLVTDCDANTYCNSNNTCAWRGCRRNTYPYGYNDYSFDQLPPLCPTGEFCPDESDHCLTQVPVGSSCQKDRDDECAQPDNWNDLAGDLNTNGSICLQYTCYYANMTVGQTCVNDNTAYTAYRDDGSAYAFIVSRDNCANGHYCDASDSLCYRGKAQGDTCSGNKECLSYNCADDGRCGKAADDVIHPPVWQYVLIGLGIFILIGAVMTTLWFVHRRVRNRNQAMLEQYYNEQIAYRQSIMSMTQAKQTLANLPPGHSMNDARASLYGDMPPVGWTSGAEIPLPPNMRRDSASIYREGQGQGLSEVQLMPHQTYQDASESSSRFRGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRS7</accession>
    <name>A0A1E3JRS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033630.1">
        <property type="nucleotide sequence ID" value="XM_019174578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRS7"/>
    <dbReference type="GeneID" id="30191640"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="59160" checksum="8C38D4EE41C5D518" modified="2017-01-18" version="1">MLLPRSLLRPHLSSRLSRCLSTSSRAPLKVAIIGAGPSGFYTASRILSLLPANSPEGNGVEVHMYERLPTPYGLARYGVAPDHPEVKNCQHKFDELAPDPRFKYFGNVLISSQSSSSPSAPSPSTALSSYTYPHALRLSFQDIIPYYTTLVLTYGASLSNPLNSVPGSSSSDNPLEGIYPALALVSWYNSHPAYADLPVDLRGVKDVSVVGQGNVALDVARLLLKPVEDLAKTDLSDDVLDVLSKSSVEKVRVVGRRGPGQVAFTTKEFREILAIPGVGYPGIDPDLMDEAKENVPPGNGERMRKRLLQLMDKQQDGKKVLELDFMKGPKAFLPNPQGGRVGEVEWNINALLSTPPLAPNSPGDSPAAPSLVAKATGQTSKTPADMVVESVGYRSEPLTGPGHEWDLPFDVVKGRVQNVGGRVVDHEGVPVNGVYAAGWAARGPVGVIASTMHDAYSLSSVILDDHLSPSASASSSPSTSPSSTKPPYTPLNTSPLPGLPERIISAANEGKVVVDLDGWGRIDQAERERAKLAGSGKEREKFRRVEEMLSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRT6</accession>
    <name>A0A1E3JRT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033437.1">
        <property type="nucleotide sequence ID" value="XM_019174385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRT6"/>
    <dbReference type="GeneID" id="30191446"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO03386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="313" mass="35962" checksum="42F03F49580EA5B5" modified="2017-01-18" version="1">MGDQQEIDLDSVIDRLLEVRGNRPGKAVQLAEYEIKYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLLCSFQILKPAEKKPKYGGYPGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTF0</accession>
    <name>A0A1E3JTF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033438.1">
        <property type="nucleotide sequence ID" value="XM_019174386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTF0"/>
    <dbReference type="GeneID" id="30191447"/>
    <dbReference type="OrthoDB" id="2017695at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="254" mass="25857" checksum="B0FABC068929D37B" modified="2017-01-18" version="1">MSAPESVVPTTIASDIPKPVIPAEEISQPPSKALDSIAESSLLDKARDAAKPYLEKAEPYVNKVSETAKPYADKAQARFEKILDKIEGNDPSTTSTPTSAGTLDKSIDNAAATTTGAAESTTAVAADTGDKAKQYLAQGLSAVQSTFTQLTNTIEEKTTTESHPGFITQVTNAVNKGIDRVEGYLNEPTDASLASQHAAPTSGSAAVAVAAGVPATGATPAIPVAAIPVVASDPVASEPVVSTTTNTVPHTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWP4</accession>
    <name>A0A1E3JWP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033868.1">
        <property type="nucleotide sequence ID" value="XM_019174061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWP4"/>
    <dbReference type="GeneID" id="30191115"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="196"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="685" mass="77039" checksum="021CCCA11589CEA8" modified="2017-01-18" version="1">MSTNSIPGTGFVDPANLNMIDPVITDELPMYSAQPLPDPSTDLLTFDPNWEWFGQLFGWGSDRDIDLDIGIQTSLLQKDTIGHGSSTDTLSAAWLLCSTPRATTPVSDIKPQDGSIEIEGRKEEGPWPNVFKPNVPDRPLKVKNVTFPLPNTGPEFVSQSSRNAMLSLIYLSHQPQWLMPEVDDFPDHDTLSHFVDRYFEQFHPIFPIIHRPTFVSEDIPAVLLLSVAAIGANFSGPEYSSLAVALCELARRMITWVARSDQRAKFDHSLLLAFTLQTALGCSCGSREMFYHAEIFRCSIVTTCRRLHLLRGLDNATEELYMKGSNPSVEERYKAYLSDERRRRLGWGVYLLDAQMTALLSLPPIFTVTEARIVPPSEESLWNAPNAEAWAAIIQRGEAVDPRISTRPKFSRLLTMCLAGDSISIKMSDFTLTLLTFTAWRMLFDQRLLQKALGVGMSENGMDMPSQPADCHIVDSQPGLLLTRLATASMSSRSPVHFRVIPSSVYHHAQMFFTRPGLLQRIKHVSGKYEPDMTQEGSLIWLKTWMADGKEVRKLLWHAGVLGALLVEFPRNSAADMSLTFDCALMFWVILKYGPHQLMSSTTESVFFDAKWFDIIPPDMWIAHGGPITFPFLGSSATWTIPAILRHFMERLSKMPWGLALQNKLVLEKLLDSELKEENEKKGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX35</accession>
    <name>A0A1E3JX35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034018.1">
        <property type="nucleotide sequence ID" value="XM_019174211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX35"/>
    <dbReference type="GeneID" id="30191269"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="104"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27549" checksum="ED510CD3111821ED" modified="2017-01-18" version="1">MLRNILSSTARLFSRDQIPSGSRSVSTAVHLGDLAPARGSTKVDTRYGRGPGSQKGGTSGRGHKGQKARNGKGVRLGFEGGQTPLYRRIPKRGFINFTSKTYAPLSIATLQSWLAQSRISPSETITVGTIARSNAIHGLSHLHGVKLLGDVDPSLPIPPLKLELSRYSKSAAKAILAAGGELKAVYHNNLSLRKEWYPEKFRGREIQSAKPTRKNDILFYTNPKNFGYLAEETPTSARKMTPEEWAKVEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ45</accession>
    <name>A0A1E3JZ45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034248.1">
        <property type="nucleotide sequence ID" value="XM_019173543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ45"/>
    <dbReference type="GeneID" id="30190593"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO06148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="404" mass="44292" checksum="87458C312ED0A08D" modified="2017-01-18" version="1">MAVLARPISALNRPLAFQACSRRALAPLRPRFVSNAAKPPTAVVMMNMGGPSTVGEVNDFLTRLFNDNDLIPLPFQSILGPLIAKRRTPTIEEQYASIGGGSPILKWTQIQGAGMCALLDELNPESAPHKPYVAFRYAKTLTETTLAAMKADGVKRAVAFSQYPQYSCSTTGSSLNELYRVAKQEKWGGAGEVEWSVIDRWPTHPGLVEAFAHNIKTALKAYPEQDRNNVTILFSAHSLPLEIVNRGDPYTAEVAATVWAIMQKLNFSNPWRLTWQSKVGPKAWQGPQTAASIEGYAKQGQKNICLVPVAFTSDHIETLFELDQEVAEDAEKLGVHLTRAASLNDNPIFIRALADIVSTHLNDYDAGLIGPASQQLLSRCQMSKNPRSEATKKWLGSGGKNMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ52</accession>
    <name>A0A1E3JZ52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034258.1">
        <property type="nucleotide sequence ID" value="XM_019173553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ52"/>
    <dbReference type="GeneID" id="30190603"/>
    <dbReference type="OrthoDB" id="2596481at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="527" mass="56506" checksum="8022FF9CA3F461B2" modified="2017-01-18" version="1">MPPQSHSHLSPQSDYSLLSSLDALSLSSALSKVDSRAGTSSASLSDRRSSQDDYEVISHPSSGRHTTLNVHLNMEETSSLATKTPTGSTGFAASDSAAPAGKSKYARRRERLRARKDADLPEGSTSSEISSQVTGHTESSASAVFVQSRVPVSPKPASVSVPPPKASPSKLAEVLARSDKDPERLSKSASRRARKWALKQAQAANKGGILASGSSSGASGLGGSSRFGGVASNNFLSVPSSHVAPSLSLDSSLDDTSGKGKTRRSRRGGKQNKQRAERLSETRDSSEADSVLDTDDTASVTTTGTTSRSRTPTGSSANSGRRRVLAWDDEDEDDSEDDEGGRATPVAQRRTAPSVLSASDASSSINSFLTDPRNFMMLKENKLRLWQSLCIEFGLVNLEEDLPDLPVRNTPQRPVQRPRADTASSSSTITSSSTATELPVYPLPRTLNQARRILKEHAHVNLVDYFEARKVGAPAFVGAYKDLLWPTPSALRRYTRGEGKFAVKDAVKDEWLNPLMRDILHFSAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF8</accession>
    <name>A0A1E3JZF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034265.1">
        <property type="nucleotide sequence ID" value="XM_019173560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF8"/>
    <dbReference type="GeneID" id="30190610"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="113628" checksum="F646FF4C139DF1EF" modified="2017-01-18" version="1">MSLSTSPSSVHPPVASVPLRDEPARDRPIDMDRTNSALSTTSTSSLPPRPLPRRRSTDASGGLDYYWSSLAGAGASSSSSSLALSLASPGGGSAMALSPPVGNASLSASPSATGLKQVRSHGNLGMHAGGGRQNSDGGYFGYGQQTHLGAPQRPYYNRADSGSSTDSQNPNPNYISSPLSISGNRPLAADHLASSPGGWSATSNYSKSATSGLSVAGLDLQQRQWSYTTDESSSSDSQYSPVSYRKKLDEPTQDSSAQDRRWQVRSSAQSGTTYVPDKEDTSDVPPPKPQPEMQDKDWEKTPREAEVEQFTTPTAAAWQERPDLRPPQFVFAAGDRAGERLSPGSNSSHTHTQGRGTPVTGTSSASRYTPTNPPSSAQPSSPYIRTPQSAGNPTGPLAHFAANRETPRSAPAWKSEFEPSGGRAEGKEKNTVKGRNRRTLPAVAPSSSTDLAGIMNGDQADQPILVFPVTSEPEPINKALPTITHTPHSPFPSPPPKDDRPPTKTNLSSSSLASSSSSLSAPPARPDRSPSRGTAPTSTFITSPSISELTEMLGGAIDEIGLIDSRDTPPPNMSAPPKNAGSVSSDSNSSASSGLEKRPQMSLDTDVSGDGKGLEPPAELVNKAEKDPITPTSLPQRGMSLSASGDAEEEGQAGMGVASTLPASPTCTSPSDYHSPLPEHHSLPGGTVNYPPLPRPWPSAMQTTQIKSLASPGARALAYARAINELSRGDTGLGWWCTNMQGEMNRPISGSRAPNMRKLKMGSVNSAGGGGGLVISEPSNFIQGTPVSPSAPPMLDLAPVIPHPRNVSTGSEFPMRADSYSAREISQRVVDPTDQPTALPANLPYPQVQQAVNNPGFNGGGGLRPSQSMQSVSSFTSGKKGFFSAIRKGGSKKESMSLGPPTSSPIATSPGGSVGRKDIRGLPISAPRAGTASPQKSGAESPGGLQAPRVQASISPMGPRGPRSAVSPKASSPSQSPSRKHHGRSSLDTGLARMMPPPVLGRGEREGRGSLDGGVVVIGKERQIPISAPSPLSAGSGAGGVSGIDDIRTMVDVLPHVEKSVLRAYLVNNGNDQMRALGAYLEDERHGTVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZJ1</accession>
    <name>A0A1E3JZJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034370.1">
        <property type="nucleotide sequence ID" value="XM_019173665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZJ1"/>
    <dbReference type="GeneID" id="30190715"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="291"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1052" mass="113615" checksum="F71DBD8979CB5392" modified="2017-01-18" version="1">MSEAAQELSTASLTSTVITQTLAPLPDLDTITTSFHLVTSGQAEDASQIKEAIGLGLEKALQVLGDVLAVAEGSAEEDVKGIVGEREAAVEAYLGLDEMRRRLDTWELLQPSPVASPIIEKSVGLDEGEKEKEGEEEIELDDPWGEDEGEERTTILDDPWAEQSPEISTKEVSGADEEEESEQSEIESLPLSLFQFLTQPLPLSALELASAVALGALQTICQRHWQELYPYRFCILEAVPGWVQPSELLEVDLLPKLGAEDVETWVTPLEADEALPPPPAIIKSLYIPLSLSATPVSLPSRPTPMSSEDLAGWYTSHTLSLDSLGLLDIQLAWVQHGASLGVPSLDSLGEDLSLLSRLVYDGNLTHEQHARWNLASWRSAQEDDIVNAYLSGSVPGSIAGDIRSLLMPYLYVLESRAERAGKPSAKLVEDYLNSAILSLPLHLALPVFEASKATIPTAERIIKNDLEVARLALACLYGSQERGSVVWGSMSSIFECLPVWELTGADAADEELTSTTIDSISAFVRPSASATEPPTKKDLLIFFRPLPFASLSRALDILDVQLESGEILARWGVEQRLGELLGVTGDKKEQTDLANKLVRQGGSSLAGAREEGWRRLWDDMQRLASGEGLLKGALGTLTLQERGRIYLGGLLSSGNFDITRKMIKRLQGDGAVDAVIIEKVVLEASREFYISAKSGNLHSGNMKLAYDCLLVAPSSKAITSEREYIEATSRLSSFSSFNITPSQIRATTEPLTLISAVLCGSSSDAYRYPDLMLDLASKLGCRSQVEKGLVWGMVGRSAVENEDWETGKGAVESMATVAQERVIKTKGKGKAAGKDLATADPEAKLIAETYTLAHLIASRPDFSDIPTKREFISIALELCPSEAIPSILETFRQVESGQAKLDQAAKRRRLEGIEAPKLPYEASALGVSEEERVLGSRTAAKAAKLALDIGGRLTNRQLPSPSLLSAATLSSPFGSNALLRSSSRDSRVESDGGSDAGYSVGTPGSTGTRELFDHLGREEAERVRKGARRALVRGVGWLLGADENEISGADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZN6</accession>
    <name>A0A1E3JZN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034434.1">
        <property type="nucleotide sequence ID" value="XM_019173729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZN6"/>
    <dbReference type="GeneID" id="30190779"/>
    <dbReference type="OrthoDB" id="2576330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18274" checksum="C1DF4F811D5C4B68" modified="2017-01-18" version="1">MDRQLESRLLIESITKPTKLSSKDTYSHLQNFLHSLPVSPQRTQLERLTDALGVEVGQIDISEGERREAEREARRLEARQERRKKREEEEEARKQAELEGAVEGLEEEEEGDMENGAVGQEGEEGMEDRGDVEYGDVPNEDGDDEPDNEDQAEQMDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K020</accession>
    <name>A0A1E3K020_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034471.1">
        <property type="nucleotide sequence ID" value="XM_019173766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K020"/>
    <dbReference type="GeneID" id="30190816"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000075">
        <property type="entry name" value="Related to IVY1-phospholipid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40616" checksum="1AAEAC9560A1B3D4" modified="2017-01-18" version="1">MWGGRPASPTFSTTTTGSKINLPENHTLITRKDLRQSTACFEELMAAAKAYRNALLAMSSATAAFATAMEACSRVKGCRSSNSALAGASGLQYLVSNHEQLLADTVYRQFEIPLLEALDEYKLVTADRLAQYEKSLHEQSQKIRKTEADNLKVGRRRKRDLQQFREALAELQRQVDDLDTIKASYHEEVLEGEDEVWETVLGRVAFVVRSQLDFYEKIAGKASDPILEPMVMSIPDPFDAYGPPKEEGQIFSVLAPLGLLDSSAPQSPKPGLPRTSSPTPASATSPGPSASPPKSPHSQLLSPTKQSSSSSSINADNVLGQFNEWLDEADGGDEIGRKSSRERRELSVIDETQDGVSVLASEGGERDDVSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2D4</accession>
    <name>A0A1E3K2D4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034815.1">
        <property type="nucleotide sequence ID" value="XM_019173089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2D4"/>
    <dbReference type="GeneID" id="30190130"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="847"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="575"/>
            <end position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1015" mass="108923" checksum="881C31F8C1AEFE37" modified="2017-01-18" version="1">MSLFRDIPAPPPSSSLFASPPKQQPEPPVKNHPSSGSISRNDLFTTSWQPDIAPPRPLQSEPIGNSAGGSSSDEDGGSRTMPTVTSPGRISGYHANTKPSPMRRREFTSLDSRGPIASSPSKASALASTSPTVDEFGVSRPSAIPPSTHSQGLAKEESPRTSSFFDVATDLPAPPPPAPRLTSSIPSSSANSHMGSPVSGLSRSASLRRAGKTLPAPLPLSRTGSNGVGPGSIAHAPLSFGGGEKQRSWDSYTSSHSSTPSASGSYVPAADDPLSPLHQSPQLPPSGVGLTDDWIPPLPPSLDDIELRLIPNKTYLLGQGRYSDVYLGAYKRVRKKKIPVRGKDLLGRPSRLSDNIISLDKKEEGSDMELEVNEDGDGLVGGSWKLCAAKRPAADRDAQTMGLREAFFLNRLRATSPAHERSTFPRSTTRTRAVSPLRDTFAGAQAQRKPVRNGSVYIAKLIAVKEDFDNPHFSSHSRSTSDAVKGDKSGSHLSVSGTLTRQRSSTMLPFQTPPNAQIQSAANKVSAGVSKPIPSTEITNLPSFPSYPSLAEAIRQEQYSNPPLPSISRLVLVLEHAPLGTLDRLLRTSPQLVGKKLFARWAREATEGLEWVHANGVVHGDIKPGNILLTADLHIRISDFGSSLLIHPAHPPTDGVGLGTLPFSSPELVDKSATFSFPVDIWALGATLYQCITGREPYRGLRIMELTHRVKSGGLWPYEESERLSRVGQGVEVDGTPFPSAWREPVCSGSSDFATNSVAGIRRAGSLRVPSTYSTLGKEPSATFSGRPRLNRMTSAESIRANEDATSSASPAAIKLWSKWVKGGAGLDPVTALLAEDSTPAEFWEEMQASGGVSRQSSLRRSTSLRRDEDSDGEIEEGTRQRQALKIVTQPVPYSSPALATPTVNTLPPSPAPTPSPCKLPQTEGFLPLQPPAPQPQTPTRRQTLTEAYSDGSPAMLYLDQSERVSEEVRDVIKGMLEVDQWERLEAREVRAKWDELGIGAGDDEIGEMEVDEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2P7</accession>
    <name>A0A1E3K2P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00884</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034782.1">
        <property type="nucleotide sequence ID" value="XM_019173056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2P7"/>
    <dbReference type="GeneID" id="30190097"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO07305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="32900" checksum="A6C63390CD8822E9" modified="2017-01-18" version="1">MSQESDLQPGQNLAHLLPPSWTADVQRWFAEDTPSFDWAGFVVGEEVQEAILWGKSGGVLAGVPFFDEVFKQVDCTVEWLLPEGSVVPEGTKTKVAIVRGQARQLLLGERVALNTLARCSGIATVSRRFRDLARAERWKGVVAGTRKTTPGFRLVEKYGMMVGGVDPHRHDLSSMVMLKDNHIWATGSITAAVQTVRRVAGFSLLVNVECQDFAEADEAIAAGANIVMLDNLVGNDLHGAARQLKEKWAGKREFLIETSGGIVEGSLTGRVGPDIDILSTSAVHQSCPHVDFSLKIQPKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Q7</accession>
    <name>A0A1E3K2Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_00878</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034776.1">
        <property type="nucleotide sequence ID" value="XM_019173050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Q7"/>
    <dbReference type="GeneID" id="30190091"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO07299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="620" mass="68958" checksum="473887FEC9F92859" modified="2017-01-18" version="1">MPTISVDKAELYRRLEKEYTTQEFDELCFEFGIELDEDTTVEVEEARKKGLPTSPPQLKIEIPANRYDLLCLEGVARALRIFLQKDTPPQYALSNPEKIQEVYVESSTSPLRPYFASAILRLARPLNQLEYESFIDLQDKLHQNLCRGRKFVAIGTHDLDTVQGPFRYICEDPKKIKFAPLNKETESTAEELMGIYEGDRHLGKYLHLIKDAPAYPVIYDSKGQVCSMPPIINSQHSKIVPGKTKNIFIDTTAVDKTKLDIVINMICAMFGEYCEVPFTVEPVRVHMPDGSSHISPPIAPRVTTASSSYINAATGLELSREQICTLLTRMSLSAKPSATDSDALDVSVPCTRPDILHECDIMEDAAIAYGFNNLPQSMPTTNTVAKAFPVNRLGDIIRKECAMAGWIEALPLILCSHDENFAWLNRPDPGNLAIQLANPKSLEYQVVRTSLLPGMLKTARENKALALPMKIFEVSDVAVQDAKAERQARNYRRLCAVYMDRKAGFEVAHGLLDRVMQILSVPFIGAKESQAEYGYYIASADDPTYLPGRAAHVFYRPKPTPAPASSNPLSNIASDLKAALPGATRDINIGSLGILHPSVLNNFELIRPCSSLEIDVEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2R5</accession>
    <name>A0A1E3K2R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair and recombination protein RAD54B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034786.1">
        <property type="nucleotide sequence ID" value="XM_019173060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2R5"/>
    <dbReference type="GeneID" id="30190101"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="335"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="666"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="870"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="977"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117091" checksum="F53289C97E1601FF" modified="2017-01-18" version="1">MASSSTKPRRSLGAIIDAIPTQRDYVPDSCSEGSGSEDEGSSRLPVQSLKPIPLTPVASNRGPRVSGGLPNSGLAMKEREVQGGAERGQAPTEEYDSAMFFSVMWRKPQYKKVETWDGDATIKILGNRIAMLDEDGNQMAVTVVGSKVIKPEAEFKIGGYEIQVDHRIQAEEFKSSTSILNRPRGVNAASYSPATFAKPFRPPTQKAAASPMQPFKPPTSVTSHTPVAGPSTTSALPTAAAAQKAVAAASFYGSTTPKPRVERIVIGEKSNKERLEWGGALYNPKTPGAIVMPRPTEKEAKLKGTSLVDVVVDPTLSNIMREHQKQGFMYECVMGMTNAEGEGCILADEMGLGKTLQTIALIYTMLKQSPFANQSGIIGKAMIVCPVSLVDNWRKEFKKWVDRRVNVLVADGAYHRISSFVNNKHQHVLIIGYERLRKEIRDLASCVPPIGLIVCDEGHRLKSKDNKTTKMFDTLKTQRRIILSGTPVQNDLGEYWAMVNFACPGVLGKYAAFSKHYEKPILKSRTLNCLEKDVATGKARAEELAKLSREFVLRRTAAVLENYLPPKYEYVVFIAPSKLQLSVLSRLLDPKIVGKFIRGHGAQSLALIDIMRKISNSPMLLRKKDEETGDNGRTDSDLSTAKSAALSAIPASTHINDVNTSGKMLVLDKLLHSIHTTTDEKIVVVSNWTSTLDLIQGSCKAKRYPFLRLDGSTPAKQRQELVDRFNKDKARKDSFVFLLSAKAGGVGLNLIGASRLVLFDSDWNPSTDLQAMARIHRDGQKRPVYIYRFLTTNAIDEKIYQRQITKTGLSEQMLDHNSSEATTTNKDSFSTEELRDIFTLNLRTNGCQTHDLLGCDCTLVAREKTLQIESKPAKVDSDDGEHDVNELLESESGEDEDEEDEDEKPKFVSANDYDPEPTPKMRRKAAKEQSNKLAALKHWTHYDANESKSFRGVQDTLLFNMLLDSWEKDDAVVRDSETEDEEDQDVDEEVDELISDEEGATKKRKSMGGNKGSRAKKAKTSDVGAAVTSRKKHNLKTMAERGTGRVTFVFEKVSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K370</accession>
    <name>A0A1E3K370_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034953.1">
        <property type="nucleotide sequence ID" value="XM_019173227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K370"/>
    <dbReference type="GeneID" id="30190268"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="433" mass="48249" checksum="E8F24D38ADD76A1D" modified="2017-01-18" version="1">MPRQFVRLADRFSISPPSTYIDKPFLSLLPESIGADSKLEYKQVNLGNVEKHAELFKLPKEWNGRELYGDEVEKGFDVVFDLTGDTSFDKPELIQISHTYQVSFSLSTSAAALSPSLKPKAYVRLTFPFYEMKNLPSSSPGHKEEADLKPDGVRGVWWHEVLRGLGRLAKKEANGELGGLKVGVVRCGAWYGRGTWDGEVVPRVVAGHVYQYLKEEMKFLYNSDLRINTVHSSDIAQALYLLALYLLQTPYATILPSSPSIPFPFAPPSSGNSIFSSNSKRSSLSETWKTVSTIVPKEESVRLPLFNVVDEADSTQGSLAKVVAETWGIKFGFLSSTVATLVQQFAKTDFSEMVEDVNEMHVQAWSDMLSKSNPPIPSCPITPYLDEHAFRKRSICLDGSLAKTTLGFKPAHPTVDVGEIKKIVKEFQDDNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3P5</accession>
    <name>A0A1E3K3P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034624.1">
        <property type="nucleotide sequence ID" value="XM_019172898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3P5"/>
    <dbReference type="GeneID" id="30189939"/>
    <dbReference type="OrthoDB" id="2572300at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="103" mass="10783" checksum="21D8C8AB77CB23B3" modified="2017-01-18" version="1">MFPSTVALRSSAVAIRRPAAQFATQRASVGSIGLGVAGKRFNTNTTASGKPKLRFRFGLRDIPVETYPVVFVVAAACVGAGIALGRQIWSGDLRLKPSGPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3S1</accession>
    <name>A0A1E3K3S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor tau subunit sfc3/Tfc3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034960.1">
        <property type="nucleotide sequence ID" value="XM_019173234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190275"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="4">
        <location>
            <begin position="1601"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="961"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2151" mass="239952" checksum="CC03B707EE4C68CE" modified="2017-01-18" version="1">MLGSAPSDLQAHLAGIINPIDDQTFQYIWQTLVIQSNIEVILTARPIAVVSEVDPKGKGKATDDTETLSFKTPIVVLDKVDGLQYNGIGNVAVSDFKALKEKWGSRLRVRCTTEEIHYQLTGKHQGTLNLSKDALSLLQLVAMARGKGIRYMSLVGLLGGGDWYSRMNMLVDNGLVAKVEFLDRNASSNMIVHFRYLHLNPQYLSFCRLNPQLQNTLPPDVAASLRQDLQREEEEEIAGGEEDEEHAEDEDVGEWDLGLAPISDMDIKSPHMVQDRIMRILDHPKLTNHLIRYRGLIYAMGWRSKTIQKQHRAIRKVITNMVDAGVVENLLVGDGKKQVLCLRLAKYGQNQEVVGREEVQEEQKSIEEIARLPLYKPMPGVMVTRTLERQLLELIANAPKGIVRGELKRKLNSVYLRIVEKILGMICGEQGNRFPDQFWALAVYGAVISTGRQSYINYLTSFHALAFFAEHDHQHKVKPEPSSSGHFLDLPPHYYRSTQQFIDYVERGSTDSDLEARMPNVPGKTKSAPKKRGRPSKRETQGGQATKSCEPENRGRPKSYVVVYNDIKGGGEHGRERRVCGDMYHHPDVPDILLFSWTTGLVYPASDSFNPRTKQPPPPYEQWQLDQGRPPAFYDQYPHAKKRSATLRKPKWLLEMEGSLVGGGGYSDYGAVGDGVRGDGIQEDGDDGLRASKRRKTTMSYVEAGEEAESGPSGTTADDQSQSPPPPPKKPGKPPKNKPATTGAKRGRGRPRKNPLPDLESAADPTVTLPDTGDMSQSAATDLQNSQTLPVAETTAGDVIPIEASGATESVKPPRRRGRPAKVTPATGASNTPDLDQPPRRSGRPSKSKGQDIGDGIPSIESSLLSEFSPHFGTDIESETFAAERISVEKNANVAEPAGFASRSIAVKELGRKRKAITPQGQDQEDDHGNSSVAVTPLQTIQPLPASPQTPVVSVVDEEVAAQSATRTKKKRKVNTGAEMTSRGTPSIGDAIRATQLYDAIRDFGGAVKKRDAPQVLHDYLAKTQGVDKAFITTPTYAQRMFNILIGDNRIRETKTKFPDHFMRHIDQTFYYVSDLPDDTLNAYIREQAAKRQAPPKPGTKEPTLINAKYSDFARPSHPTKRYDGQSVEGSAVDFTDGRQFHLRESAHVVPQLYGYKLQRYIRTAILHRVVVEIASSPDSQCMISRSPPIFETAKLIGDIRIGDWFALLRYTAYQEHVATWLEDPAHREIKVRDVPAEIDTFSKPFLNPMGSQRFTVLFEILDALNCVTPLVAAAGGAKVVSAGDADFQRSTMDLSPYYLLHSYVPVYHLAIEPDAPLLGIVQVKTAIEVERYWKYLREAALVALPIDIVQRVDPSSVQEAMPFIPVYPKVYKVTPKFPQSIKNAKKWEDKPWVSLRQETALKSAIDHHTATLREKTIKQLAWDVALPPDVAEAKLKQLMQAQVQVIAHRDEELRRIAVRATERREQARQSIQARLAEEEVATRQVWQDRVKASALGQGIDYTLELLDFLTERTKGVGKKESVPDAQVTYWVKVWEMCRGMSGEERQSLMASRKVSLKLQGKDSAPKVVRQKKGRGERTTKVDDSFASGAGPSAASGAKRIRRKWSSEDDDLIIDGEAIIRARSRTNNYRGRACMTALFPEASSQTLRNRLTHIVSEPGMATYLSRLEQAWYEIWMKHRGTEVLPDDNIHSSVAFDIKAHLEYFRKSVDKRNLKLLATSVPVRQTEYAPNLPADIASLLQQHDYSYIKTKNHTFDTLADSQMAEDLHVSHLARTSFVMPRVQEESIMDLALVENDRDTGKLTATLKSIIATPSISYDPHVGQRLLKFWQEPVYEKIIADLVDKTVIRKIGSGSVAGTGGRRYDFTHQWQQLSDGPLPGSFFTEAGQMEKKLEMAGAEGIEWPLIGKPGELGALLNDDAYEFDFKVTRVKAAPPLADIPLPRPDACKAPAKWNIVPDIDDSIVTSVMGAITSAGQEGISKPSLLALLDLVPRQLAHALARISSDPMSRIFWGGYDTARAIDCEYWSAWCIETRPYESKDRADADRSTEPRRWVDVYGKVMEKEWRRGCNAVIAHLASRPGINQRSLARRVSSIFDRLELVDILDFLLQKGALTRRWVDVHMDTALPPVEATSIEEEEFVGWWPMTSALLGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3Y3</accession>
    <name>A0A1E3K3Y3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035020.1">
        <property type="nucleotide sequence ID" value="XM_019173294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3Y3"/>
    <dbReference type="GeneID" id="30190335"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="60736" checksum="F13C93ABAAAB4362" modified="2017-01-18" version="1">MLPKRTPSPPPAHRAQLPPDHFLALAPSFNQGNYEFPSGAPSTASAASNGLAPNTASLASADFDVDVRTGFLPPSKNVARLSGYYEMWEEALDAARGSGVGDGLQVGGRREKDQLWRAGVASLPVLPTSDLCASLPHLRRAHVVLTFLAHFFAHTSPPSTAEPKEPVPIPASISVPLLEISRMLGLPPILTYADTVLWNFLPVNPAVQSSLPGNPPRDIITTFTNTRSEEQFYLISSLCEIAGAEALGLMRRSLDELFVADATAIRRLTVYLRKLAAQIDRVGDITMTLMKEVDPEDFYHLIRPWFRGGDGDGPGSAGWDYLGLASGEAESSTHEAESASTQGQRGKLFSGPSAGQSSLIHAIDVFLLVDHSPTEEERREAMEAAENRPEESGASIQMDSTPVGATEEQAPAHALNKPKSEATFLQRMLAYMPLPHRSFLIHLSTHPTPLRPLVIHCAQSHPALAEAYDGTLEALRRFRERHMRVVSKFIVQQARRQPGERVRALLGVEEPEEEKIEVDTGELRGTGGTALFKFLKRCRDNTTKAMVRPTGAGYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4U0</accession>
    <name>A0A1E3K4U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034739.1">
        <property type="nucleotide sequence ID" value="XM_019173013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4U0"/>
    <dbReference type="GeneID" id="30190054"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130750" description="J domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="396" mass="44100" checksum="9B804C2845504D40" modified="2017-01-18" version="1">MSFLISSLLASFLPSQITTILLPHLSSNLPTIFPPAPKGSPTYARNYRVAFTGVICVWQAYTLAKGGLGGEGWYGLLGVTKSADEDELKKAFRLIARQHHPDRAGPGSDDFFIAARKAYETLSDPVKRYAYDRFGPQIVDWKAASVRENIYTGLQGSLGFYIVSGIIMFALAIIGKARAGSYWVHTLFASLLAIELSLILSPALYSPSALVTFFIPRQLLAMPQYLQIALLHRLFTALSITISQLAGVWSGDSSLSRAREEQEWQLVNDMLVRMNEQAQEEFHADIIPLMSTGNPHQMSELIQDSMENVLYDRILQSHPQIRDTYREARIRAYQSLPGPARTRQPANRPSPAPAKVPPPQPIRISLEDQLKVAVDVPLPPSPPPTPKMKLRRKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K552</accession>
    <name>A0A1E3K552_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035137.1">
        <property type="nucleotide sequence ID" value="XM_019172195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K552"/>
    <dbReference type="GeneID" id="30189218"/>
    <dbReference type="OrthoDB" id="10453299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16506" checksum="22241B0B6AABB5FF" modified="2017-01-18" version="1">MASSTARLAPAGRPPSLEDFFISAVQTILSSSSTNAPYSSAPWARSTKSERSTNDKPLVVAMAEAKVCYFNTTRTFPPLHHFRQEELSQMLLELFYPIQPERYHSRRYKFVRKSKAGSTPARYVVHGKERRQYEEDKAEFDDAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5K1</accession>
    <name>A0A1E3K5K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035152.1">
        <property type="nucleotide sequence ID" value="XM_019172210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5K1"/>
    <dbReference type="GeneID" id="30189233"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000001">
        <property type="entry name" value="Putative alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="395"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="892" mass="98605" checksum="7A953F0E8CF0F2AA" modified="2017-01-18" version="1">MPPRPPPPRPRPPIQHRRTPIPLYHLTLALFFLLLALTIIYVPISGVYDHLQSLQAYISSPKRDDPFVRLVEGKGLDGRSLLERAPEGEVYGHADFQDGRRQTVRPEFLEPNSEALGWVNVNLGNGGPEPNLSGGMIPAISTPFGMTRWTPQTRANYVSMCPYNQTDTKLHGFIATHQPAIWMGESAPLEVSPSLANTPKVLFDDRALPFERSEEYASPNYYRNLLKDEGGHVEAELTASSRVGHMRFTFQKSSPSSSSSSSSSAEVVPRILIQPARSTFLVHGDKPDDRVPYHPSGFIRVDWDKGEVWGWGDERQDHILVGDDLPAKDFKGYFVAQFSHPFSRFATSKNGTITYDDEQAEGAVLAGFIEFEGGDEEDEMVVEMKVGISWVSVEQARRNIELESTPFPASPKDSSTWAEHLDRLSVSGASGSNKTVIYTSLAHTLVYPYEVSENTTFLTRANSSSPTWSGDTEKEDGESTVAYYSGYLDALAKGESYSGYSLWDTARAQHPLLILLAPSRVPGMITSMLQDWKEGGWMPMWKNVVETNIMVGTYADAVVAGAVLSGVKGFDLDEAWEAVKKNAFTPPERDTELQFGDREENTPQEARAGLTEYTKLGYVADDLHTESGSRTLDYAYLDHAAALLASHPSLSHLDLSSTASLLTTRSKNYKSLWNNGTGFMEARNSDGSWAGDENGWTEGDKWAYSLDVMHDVPGLAELMGGNASFVDFMDRHFAGGHNLHTNEPSHHIPYLYSLASAPDKSQFWLHSLASSEYNHTAAGLSGNEDCGQMSAWYIFTALGFYPVDPASATYVLGSPLFDKIRLRLPAAPWDEEGGERVLEVVADGASKGRVYVKGLTVEGESWEGVDVSHDVVTKGGKWVWEMDDRPQKWGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5X8</accession>
    <name>A0A1E3K5X8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiple drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035099.1">
        <property type="nucleotide sequence ID" value="XM_019173373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5X8"/>
    <dbReference type="GeneID" id="30190416"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="673" mass="72982" checksum="186B460552D4BA60" modified="2017-01-18" version="1">MSIDTTSTRVGQPEKSTSTLESKPLSSYTLKKRLWRPYVTPFEEIIAKKCQGQGTAEDPYIVDWLPNDKEDPQNWPSAYKWTTIFVVSWMTLAVALSSSAYSGGIADIMMDFGASRELVIAGIALFVVGFAFGPLFWAPLSEIFGRRIVYIISYAFLTLWTGAAAGAKNIGQLLVFRFLAGLFGSSPLANAGGTITDVLNANQRGLGMAFFSAAPFLGPSLGPITGGFLGLTQGWRWIEGFLCIFCGVLFIVGILFCSETYAPMLLRRRAQLLSKVTGKVYRFRGDAKKPLEIGSMFKMSLIRPWKFLFLEPIVTILSIYTALIYGILYLFFAAYPIIFQSGHGWNTGIGGLAFVGVLIGTILSVLLSIYVSNPQYVRIAKKKGGRADPEDRLPPAMWGGALIVIGLAGTAATDGPNVHWVAPIIFGVPFGCGIIVVFLSILGYLVDSYTIYAASVLAANSVLRSLFGAAFPLFTVQMFDKMGVHWGVALPGFLSLACIPATYVFYKYGAQIRAKCKYSADAEKQMAMIMAARMAQAKQEDEEARAEGKEVVYQPAQGDGVDTQPTEQEGGLGRISSRAGEYAPRASFSGTRPVSVPNPENPTSTIVGSTSATATGATGAPSTGAPLSRVATHQHHDWTTYEALAGRDENDLEDEERVRLGELHEQFDGRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Z0</accession>
    <name>A0A1E3K5Z0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adenine nucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035444.1">
        <property type="nucleotide sequence ID" value="XM_019172502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Z0"/>
    <dbReference type="GeneID" id="30189533"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="304"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="44933" checksum="2E969A2FE994974F" modified="2017-01-18" version="1">MATTSHPPLTPFGSALAGALGSVFANSLVYPLDIAKTRLQAIDDPLADLEPDAEPDPAATPFEEKTQEWGMLTMLLRIVHTEGWKGAFHGFGASMIGTFSMQFAYFFFHTFLRKTYLARLSSSTAHLSTSTELLLGALAGALAQVFTIPVAVIATRQQLWEPPSQPAISDKQAWQDDSPSLLDTAREVIQESGITGLWTGLKPSLVLTVNPAITYGVFERLKTWRLAANAKAGRGGPKLSAAESFWLGAASKTLATVVTYPYIFAKVRLQAKSVETVPLAKEIQKGVAPSYADMAKSSPSEGSTVLVEHPTSPSQVEEGENQAIKPIEAVREIEAEHPHPHPPAHHYRAAIPLLKAVYAEKGIKGLYQGLGPQIFKAVLCQGILFVSKDHFESYAWMLIVLFSQLRVKVGSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K614</accession>
    <name>A0A1E3K614_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035233.1">
        <property type="nucleotide sequence ID" value="XM_019172291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K614"/>
    <dbReference type="GeneID" id="30189316"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="808" mass="89639" checksum="D338274D6D983176" modified="2017-01-18" version="1">MDGDALGFRCDHPGCTKAFTRKDHLMRHSANHSQTSFSCSKCSREFKRFDLLQRHEKRNICGEEAASGSGRSRKKRRVSESDSEECAPSLPPPHRQPPPPPIDTMSSNAIASSTIVYPNNTVFAPDGGATIPNNQFDLNAPLPSAIGNPIAGNDFVIGEFMGDWGFSLWAPEQWEALLHESLAPTNEPMMDLPWNMPDMAHMPQQESSERGQDKMASAMVVSRLQRSYPEFDVPLSWVIEAIQTYWSRTAPTFPFIHRGTFDLATAPTELVIMMAIVGSVHMSPRRSFLSLVSKIRGMLVQGCGLDMPVTTLQTFCLCHVHDTWYGTAESQFVAQCMWPVMVAHSRKKGIGVVGKTDTEVHQEEAWAAWAKEEERRRAAYCVLLIDTQLSAFWNQHCSRQLSIFAHHLTLPSDRSQWQAPTASEWFRLRIRQPSTPPTPRRAANQQRSGYLPGLHPEFQVSTVTDGYSSAILASLALEPLAFKADLDNCLTVQMILIGLIAIAWDCRTRGGMGIRFKEGTKHWRSIVFRSVVALRAAYEQEVVRMGEAIESRDLRDSFAICIISILSDIPMLCVAAGSTSFCGSTIGPRQYADAKRRLRLWAKTDDAWTCVWQCARYLRQSLLSEWGLYTPWAVFLTTLVCWAYSETLVREEPPLAVHQPLPHLTQPVNGSAYPPSTSTQISPNTMHISRPHTLSHSPHNVTHPHPGGMNGHNGHNGHMPPPPPTPAQQNKEPIIVFLDKILCLPGRMDVLEGGEMDRLMEYVASVLEEVNGGGTPIMGGMGIGAGGGQGTGRENGALLRRLVRGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J0</accession>
    <name>A0A1E3K6J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00347</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035471.1">
        <property type="nucleotide sequence ID" value="XM_019172529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J0"/>
    <dbReference type="GeneID" id="30189561"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000001">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="13">
        <location>
            <begin position="295"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="502" mass="57561" checksum="F533132C95505FD2" modified="2017-01-18" version="1">MFRPALRQSSSSSYAAPEVKLSKRGHNTRRDSPYPYRLNLYERPPSLDITLEEFEACAIARLRVLSYIESLSHRSLQYTQFASQLDKYSKTHIPLASSTAKNENLDDQRRRDEIGHWVLRLAFCRSPDLRQRYIRAESQLFRSRFESDDKQEREAFLDSVSFGYDKVDDAEKAELATQLKAMTSSVKGEHHRNDVWYKVPWYNVPDLVGSRKVFIKGGFAYVPQSLQFSLVLQLFCDRLEKALEFTAKNLPRLDEDERLGPVIDHLVASFLSGIGDADYQPAENAGDTITADTIDEVARKHFPPCMRHLYDSLKRDNHLKHYGRLQLTLFIKGLGVPLDQAIIFWRRGYGPKMTDDDFNKNYKYNIRHSYGQEGKRANYPPKDCQTILTQNQPNGSQENHGCPFRHFSPDNLTTFLSSTYPDHFTRSSPAMKEIIDSVKGSHFHVACTRVFEVTHGVNRGEGLGNGESVSHPNKWADRSREMEKEAVAAVQAKVEESIVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6K3</accession>
    <name>A0A1E3K6K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035673.1">
        <property type="nucleotide sequence ID" value="XM_019172731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6K3"/>
    <dbReference type="GeneID" id="30189764"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="22696" checksum="759625AF82471A19" modified="2017-01-18" version="1">MVLVLVIGDLHIPNLVHDLPAKFKKLLVPGKIGQIICTGNVCDKETYDYLRGIAPEVLVVRGEFDENPHFPLSLIVQHQSIRIGVVHGQQVVPAGDPDMLAALARQMDVDVVVSGGTHRFESFEFEGRFFVNPGSATGAWSGLWNGEVTPSFALMDVQGPVIVTYIYQLVNGEVKVDKVEYRKPDPTPETASAPNLASPRPEIASRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6S4</accession>
    <name>A0A1E3K6S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035472.1">
        <property type="nucleotide sequence ID" value="XM_019172530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6S4"/>
    <dbReference type="GeneID" id="30189562"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027263" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="28"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="315"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="477" mass="52214" checksum="02418256555E356F" modified="2017-01-18" version="1">MRLTASPLPLLPLLSLAALAAAKSATGDRVLVVLESAVARDDYSHFWASLEQRGFQLTFRDTKARDAELIKYGEAQYDHLILFAPSSKSNANNLVAIAPGFAPKAALEAQLKGLNTLYLLSSDIPESQREFFREYDLEFVSPENTLIDAFAHPSDQSLSTVLLSPTETAIRNGPILSNSTLTGGPIIFPQGTVHTTGQNPYLIDVLHAPKTAYIGQVKAVTGDEAEVEKAVGGKKGKDALQTGKKATLVSALQTRDNARAGFVGSGALLSDKYWGKTVKTLDGKTVETGNAAFATDFTKWVFQETGVVKIVSSTHCREGESEPRTLYTKKDDITYSLTLAQHATLPDGTTAWSPFLADDIQMDFTMLDPFIRTAMVEDKNTTSAESTTYQARFIAPDRHGVFKFVVEYWRPGWSYIRTSTTASVVPLRHDQYPRFITGAWPYYIAAISTSVTFLAFCAIWVSLGEADRDVKGKKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6V1</accession>
    <name>A0A1E3K6V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035439.1">
        <property type="nucleotide sequence ID" value="XM_019172497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6V1"/>
    <dbReference type="GeneID" id="30189527"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30450" checksum="0F7C7C859DE36717" modified="2017-01-18" version="1">MATATDFASLSVNSTDPRDKKVVIRQLTPDIVTFSVPFTRMGVLPIGGRTTAVRLSRPAKPTVTADSIQPSPQSGDGDDVFVYASHPLTAATKEALAKMGTVKWLVTPDGEHGMYIQEYVDYYPAAQAIGVERHLKEKPAIQWAGLFGPNSDGSTKKYGFEPEISLHEVYAHVNHELTAIHHPSGTFIEGDMLFNLPPKEQYTRAGGLPKLFGLFGGGTSLSPGGIVHARMANGIAKDKELLKKELAPINAAKWDRLIPCHGDVIETGGKVAWAKVWSQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K780</accession>
    <name>A0A1E3K780_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035710.1">
        <property type="nucleotide sequence ID" value="XM_019172768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K780"/>
    <dbReference type="GeneID" id="30189802"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="542" mass="57920" checksum="2A406CB33F3DF75C" modified="2017-01-18" version="1">MSLPPDLSPVYWSAWTPVRPGASVLESVHRDQGEEWIGSWDNVGLYEGNNKVPSHQLLTLHLTNQRMITIPSYGNAASVLPPSLQTHLSHVRQTEYYAGFMRSSAKITLTLGIPAQNPATSTDENDANSWSCRVCGFANESNGIAKASKCGLCGVPYAQAIASTEPSRGGSPSSSGPLPTEPNIKEDKDTVACPACTFLNSSLLPNCEICTTPLPRALPSSTPRAKNAEKDQIIRFSFRKGGDKDAYNKLKSILGDKAWERASGAGNVGTPLGPDGERSGAGIYGILQSIDLNAKAQDSHMQHAFADLEALMLRAGEMVKLAQSLNQKLSAQRSSNGSGATEEEATMIRTTLVQLGLEAPALTKEMAKTKLDYHEGLARELGGLLTGRGESGLMVGEKGRGVIGLDEVWGLWMRARGVALLPPQTLVDVLPHLPSKTNPSITSLSLPSTLQVLHTPSFSTSSILSRTLERLNPAPEDAEGAGSEEKSFSLIEFASQESLPIGLAQEFVKLMESEGGLARDDQAGQGDGAVRWYRDIMASQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7A7</accession>
    <name>A0A1E3K7A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035740.1">
        <property type="nucleotide sequence ID" value="XM_019172798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7A7"/>
    <dbReference type="GeneID" id="30189835"/>
    <dbReference type="OrthoDB" id="2575915at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14314" checksum="202BF005A4A0890E" modified="2017-01-18" version="1">MPRLPRTVLPFAPRALPQIPALAFRAPLSLPPTSLTKSPFYTHLPSRQPLTLSLLRSPLMPLPLTTTNTSPLSGALGALRNVQMGTFYQPSQRKRKNKHGFLARLKGGKNARKMLVRRLKKGRKFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K811</accession>
    <name>A0A1E3K811_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035513.1">
        <property type="nucleotide sequence ID" value="XM_019172571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K811"/>
    <dbReference type="GeneID" id="30189603"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="32038" checksum="893E623BDEBA4E26" modified="2017-01-18" version="1">MSPTQTNLVTHYARQYSGSVPSCVATCMSSGNATGCSGVTDYTCVCASTAYITSVSECFSSSCTAAEAAVGQTYSESACAYYVRCPLTTTDNSTATAEVSSTASAVLSAPVTYSHAYINIQAIFSSICGALLLLSLASGFISCRARYKRERAFTQSRTWTGVGSTMVGGNTQATGGGKSKMFASRNADPTATFMSDNFGATSSNFGGTTVNGGGQGVSFGGAFGAGAAYSAGPSYTSGNGGFTNRLAVGEDEDSKSEEYELGDLTKKSSIRESIKEEEGLDSPTTSKGPGSEVDLDGSTVHLTRLNKDHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8Y3</accession>
    <name>A0A1E3K8Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_00435</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035557.1">
        <property type="nucleotide sequence ID" value="XM_019172615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8Y3"/>
    <dbReference type="GeneID" id="30189648"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="177"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="540"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="540"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="666"/>
            <end position="670"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="711"/>
            <end position="713"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO08702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="912" mass="98259" checksum="A75CDEA79BF453B4" modified="2017-01-18" version="1">MSSESPSPELKPQVKDLEGVPERVDDSSAPSPEPPKKPVRQKKIAVLTSGGDSAGMNAAVRAVVRQAIARGCQAFIIREGWEGLVRGNTSDPTPAPTAPQTPTLASTKRSVSFTSLPPSQQIDKLSSGLEQKAQSNGVAVTDPEDVCPLENTYLSFGYGQLLRDGAGEGDIEELAAHGAQGLAIADAEDEQGRSLKGKYIVRVGWDDVRGWQGEGGTLIGSSRCPSFRTREGRLQAAENLISFGIDCLAVCGGDGSLTGADKLRGEWPSLVEELYADGRISDDQREAYQHLNIVGLVGSIDNDMAMTDLTIGALTALHRICESIDSISSTASSHSRAFVIEVMGRHCGWLALLAGLATGADFIFIPEDPPKTDDWESEMCHVLEAHRKVGKRKSIVIVAEGALDKNLQPVKPDYVKKILVERLGLDTRVTTLGHTQRGGKPCAYDRILPTLQGVEAVQTLLDATPETPSYMIGTQENKITKIPLLEAVAQTQEVAAAIENRDFAKAMSFRDSEFQDMLKAFAISSTLDVSQAAPRDKRLRIGIIHVGAPAGGMNAATRQAVRFCHNRGHTPVAIYNGFEGLLDDNVSELSWLRVDSWTTRGGSELGTNRSLPSIDIGSVAAGFQRHQLDALLLIGGFEAFNSVVQLEQNRANYPAFQIPIIHLPATLSNNVPLTDFSLGSDTSLNALVEASDAIKQSASASRNRVFVVETQGGMSGYIAAMGALAVGAVLVYTPEDGVSLKLLQEDVEFLKKRYNLDEKGKSEGRLVIKSEKASSVYTTEVLTKIFREEGKDLFDARSAALGHTLQGGVPSPLDRTRAARLALKCMQFLEEHAVPNAQSTAHHKARSAGKPVYSKGTATMIAIRGSKVVYATMDEVLKVTDMKLRKGTDEWWAYVKQLAETMGGRTGLMARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBC5</accession>
    <name>A0A1E3HBC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027779.1">
        <property type="nucleotide sequence ID" value="XM_019180249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBC5"/>
    <dbReference type="GeneID" id="30197494"/>
    <dbReference type="OrthoDB" id="3204900at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN73633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="39687" checksum="4234A1C85EBE9544" modified="2017-01-18" version="1">MSHDLPPLHDPTSPPLSNSPRSSTSPFFPSPEPTATPTSNRLKRLSLVARPTSLDLDREPGSARSARSPAPSTPDGGVRRPRSAIIGRSNIAYSPAVSRSISRVGTSQREIGGRDSLEGRVGNGGRGSEESGHRGSEEGDTVDDPQTFMDRHADLLRQIAEKERKVNELKQDLHQQETSLHQLKSRWITLVSRAARSPSSEPTPELTSTSNSLSSSSTSSSLFPIEETALTTLTRTAEQSVGIEKALSGMINQAEEYLSPEVLEGGKKFLGNLWRTVGAAANGKTPEGEENMSLGEPTRVEGVEVEKKRKEGGWAPFGSSFDLSGLQSIITPWDGSSSRHPLSSAPRQRTSEPRTPNPAPSPSSPLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBY5</accession>
    <name>A0A1E3HBY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000063">
        <property type="protein sequence ID" value="ODN73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027786.1">
        <property type="nucleotide sequence ID" value="XM_019180237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBY5"/>
    <dbReference type="GeneID" id="30197480"/>
    <dbReference type="OrthoDB" id="2577274at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="66" mass="6764" checksum="61D7B35C9B327609" modified="2017-01-18" version="1">MSASETQSNASVRDEILNEDPNIFTQDEKDDITNAFGNGPAEGSAVSEADDGTQNGGTEASQSGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD27</accession>
    <name>A0A1E3HD27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000062">
        <property type="protein sequence ID" value="ODN74237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027793.1">
        <property type="nucleotide sequence ID" value="XM_019180226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD27"/>
    <dbReference type="GeneID" id="30197468"/>
    <dbReference type="OrthoDB" id="3257061at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="214" mass="23152" checksum="6DEE9FE39BA57FC2" modified="2017-01-18" version="1">MPCFKSVASASTEAEGAGYVPPTTAPSQSPDASQPSEDVMVDVSGCVKSNSSGHHVDLRKVSALAAIKGGAQLLAYPSGTTPMQEYSAPATFAALYPHLFPCGCGSFKDPLRPKKVSFVAHIAHCLRYKDRRFPTEVNFPFVCLNIIQGRQASFQALLQTEKATFPKLVPLLKRVDVDTLADARQAQAWFPFRSGIRPGEGRCDLASEAEHHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HEV1</accession>
    <name>A0A1E3HEV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027825.1">
        <property type="nucleotide sequence ID" value="XM_019180196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HEV1"/>
    <dbReference type="GeneID" id="30197438"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="525" mass="58845" checksum="068A868E1EF7C0B8" modified="2017-01-18" version="1">MVAPDWQNIPNASDHLKWYHNKGTIKLNFFLSVIFVGMFLNGYDGSLISGLQSSDYWNEDLNYPEGARLGLLNAIGYIAGFLVGPVITYIDEQWGRRWGIRFYGVTILVGAVIGCIAGASGASGNAGYGLFLAGRFIIGLGLTSFLMTSLAVVQEITHPRTREVIAASWNSYYILGNVVAAWVVFGCSYITSSWNWRIPYMIQVPIALYLLIAVQFVPETPRFLMDKGRVDECFDFLVEYHGNGNRQDPLVLFEFEEMKEAIALEKEAKAQKWSTIFKDRSNRHRLGLTLLMTFLTNLSGSSIIYFYYTIVFDSVGITDATTQTGINAGLAFFTWFCQLGAVWTGKYIGRRKIILWVWAFLLFSLVGLCASSGVYAKTDNGNTSAGIATVALVWIYLGFFNFACPILYSYPAEIQTYSMRSKGLLVWSTVQQFQGAYVVFVDAIALDAIGYKYYAVYMPLVIIQVALAYFYMVETRGYTLEEIATAFHSKESLTLVNVLPAAEEEGFVDEETYFKDRRSTEAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP05</accession>
    <name>A0A1E3HP05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_08008</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028042.1">
        <property type="nucleotide sequence ID" value="XM_019179981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP05"/>
    <dbReference type="GeneID" id="30197219"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="12">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="35278" checksum="78BCBA36A192CDDA" modified="2017-01-18" version="1">MAPSSYIASNRPTSLQNLLDTSTSKNGTPSLDLRWEPFQQHVENFLTAIDAYTQSARTEIVARATDHYATVRDKKAEMEETEKRIQLEREKEGDMLTTLESERHVLADLNSSLSHLQNSLTKTKEQSSSLEAELQALRKEVRSEETEKERQKNMLNDMRDRDTVELKQMEEALGWKVEGIKGTFLLMRFYLIDPDDPAKEFSFIVDVSKQDYTVVPNCDPPIPTLPQLVRQLNEDRDLFSFIKKVRKSFRALIPNPPNPSTKFDDLSGPGLGLRTPGRSQRTLSSTTPAAARDVTEGLALDHLTLGKLWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPC4</accession>
    <name>A0A1E3HPC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028061.1">
        <property type="nucleotide sequence ID" value="XM_019179939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPC4"/>
    <dbReference type="GeneID" id="30197177"/>
    <dbReference type="OrthoDB" id="2577934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="586" mass="63580" checksum="82C5CC8FD68E2856" modified="2017-01-18" version="1">MLFGTIDTLSGLAATQVPPTPDHSLSPAALGRGKDTDDTDDAASHPAGSISSAISVVDSDSLGQTRSSSFGPVPRARYDTLVNALHAPYPRGDSRVQAIAAHRQQLPSAAVVKGQGLSVAALCAVLAGSSLSAALGTAALGTTRDDVLPTRHLSGASPVTFSAATASTSALVGTCEVHSKRSREAFERDNLVDDDAARFFKRSRLVSTSPGLDDNASYPPALSFSRSPSPELEEVQTPPMEVIALPDVQLERGIKRSADDFDNDVDITMEPEPKQKVQRVRERIAVPPSRALKRTTTTLLLAAPSTFIDRPAIAASAPTLAPAPFVASCAPKACPTLSESRRLQRMTTTLGQDVLRPLPLQSIDMNRPNRPSRRALKRTTSALSLATPSKPSSQLAKAKALCKTPRQASAVPRKVSESRPLKSCLERYAPPTKPPPALHFNKPGQTWPAFTFFCPIPRSRRTLSDEEKEARKARRELKASLVCEWNPETGLKEFLPRRVAGARPGDRAEECETRPCLPKRVLESWREVEWSAGAREKVVSRRGRPVMMRSLVWCKFSFSQSQRQIKMMMGMAAWERFPLIASSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRR3</accession>
    <name>A0A1E3HRR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028091.1">
        <property type="nucleotide sequence ID" value="XM_019179915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRR3"/>
    <dbReference type="GeneID" id="30197148"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="50050" checksum="61F260A0B86D0CF7" modified="2017-01-18" version="1">MAANPRVFFDLAVHDSKLGRVVFELFADVVPKTAENFRALCTGEKGISPISSLPLHYKSSIIHRVIPSFMIQGGDFTKRTGSGGESIYGGGTFEDERLEARADNGRSLLVMANRGPDTNKSQFFITLAPSPHLTGKHVVFGRVVFGMEHIDAIGNLPTDDRDRPLSPVTIIHCGELELRRPPAAAKPRSPSPTPSRSRSPEPKRRRYSDSEDAGSDDSREYRRKRKERKREKRERREKEGKKSSRRDREETEAELDERLEREEKEMLEKQRVEKLAETKRRLEEERQRIKDDGGIVYKGESSYRPSRGAMRFRDPETIAHRAPRNFNAPTYSHLPGRPRHQPNGPGPGFGPRVDRDRPPHRDTRLSRPDMGSLDKDMDRWQHDRSQHDRTAERSKFRRGEDEREKERSVSPVKEVPRAAAVENGQHSEDDMVLDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HS11</accession>
    <name>A0A1E3HS11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07903</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028120.1">
        <property type="nucleotide sequence ID" value="XM_019179884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HS11"/>
    <dbReference type="GeneID" id="30197114"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="14">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="13">
        <location>
            <begin position="328"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="45579" checksum="95D2D39ADBB9CB98" modified="2017-01-18" version="1">MEDLGLREGDHAVTVGMSGGVDSATTLGILKDFPIHLDIIFMRNWDPLLSESSPDSDSPAPQISLSYTPPSSPSSSTPKTPNLSPCEWQRDYTDVLSVSSHLGVPEAKVRFVDLSKEYWSRVFEPAVGVWESGGTPNPDVDCNRQIKFGALLDVLPKNDRHFLATGHYGRISHFPSSPSRLLRAADTSKDQTYYLSQMTEYQLSRTILPLGGLLKKDVRRLALHWDLPNAKKAESMGVCFIGERGKFGDFISQYTSPPPPGFFTTPSGTRLSQHKGLWHYTIGQKARLGGQKEVLFVAKKGVGREGEDILVVPAGHPALLCSSVRTSSFIWIHGGEEAKTIIKERPAGVMVQVRHRMEPTPAKVAFGENLSDVKVIFDPPLVGVSPGQVVGIWHEGWCLGSGVIESTECVDESVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5I3</accession>
    <name>A0A1E3I5I3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Suppressor protein SPT23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028409.1">
        <property type="nucleotide sequence ID" value="XM_019179641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196864"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1454"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="5">
        <location>
            <begin position="829"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1361"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="954"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1495" mass="159934" checksum="51116BDD2F225A2B" modified="2017-01-18" version="1">MDSSSASSPFSTRSTLESSPEAQGANGGHGGKASGNGLVSMIMGGINGSIPQHAQQQQSPYNYQQDIKPFQQQYQNHQQHQSFPAQQDVKPFAQNPPIQGQGQIPAPMSSSRLSERINAIKSPAESTSGMSQNAPTPAGSSNHGGSRAEAPKRKHELEGTNVVAPSLDEVSQGSNGLNQILLQGDPQTADKSRVETAIRIIIDLLRFAPLHTSPPPPISLHPVLPLGPNGEPLYAFERIATFHGLRLQAGTTTKTSSKKQLQAIGHIPKEKLAYLETAVYMSGEGDGHGKRIYVCKRCRNREARRREAKDRNRKRAQPATSDSDSSPHPRLPRQSLVPPSIDFVTSENPDDYDPKRAGQVVEEPSWDPDVPDWRHDIVLFNTPSEVKMEDGSCNWLPFRVVCYGKCHGEKVGFKIKFTMRTHDGRIIASALTKPIRITDDHKTDTSKPKATKPLTNAVDGPAQAPVPRRKARPSVAGSTASVSASVARQQSPTPSESESVQSFQSLSEAGAVMQKQTPSARTKPYERPQPQVQAQGPQQAPSPVSYINNQMAGLPSANFHTTLGQLTPGNPEGIQHTHQMRSSTSPQQALPTDLDMSQFINTVSPHQLRGPQFTQQMPGNNFNVHRSSASSVASSTGASPRTNFQGLGEDMLSNNNMFNHNLFDSMRMGGNQQPNGVPGQDVNGPMLYPGHETDLANLMSSNFSHLLSSTAVDSSRNSSIAGSIDNDGASSSAASAWSGWDDRSSVFSQSGLPPGSTVVDDFEGLGDMEKYLDYPTEQQGMGQSGGLGSPARGVNFPGLPFDNLQSQYQHQPSLFPSPAVQPQAPTPPQPTITDVIPEQGPMAGGPMIAVGGTDFQPGMVVLFGQRAAVTVFQSSGFMKCKLPPSPYAEVVDVTIQGVGSGTGAQDRKTKFAYQDMEKDAMKLVLAIQSQYQGSSANTTQRLHQLPGQNNGHWSSNSGPSSSASAQGPSPGGNTMNEATNVTAAFSPDAEEEDENTDSQTSSMDSKSTDSMSSDLQSTLITFLASIDSHAPGSLRASGAINCRNEYDQTLLHIAVVLGFSRLVRRLILGGAEIDSQDDNGYTPLAFAALCGKCTCARVLIEAGACYDRATNYGEMPLDLAKVGEHGKVERLLLSAVWSTVTDPAVPTPAAAPPVMTGKKQAKQGESPKSVATSLASSIDDDNPSSGSEAEVDLAEITLSVPSTRRKSKSRKSTSDGKGIKSTKKTTAAKRGDSMSAIGTDGVEADQPPPYAPPTDHSRVQPPADDDHPSGWIKTLSNLPHLPHLPHINQIPNGVWEHLPSRPSFLGFDKTPAESSESQNGGWIVFPAPSWDTIQRMASPDEVKLFTQAMAAAALNAVVQTGVATPPSKSSRRRDVQKTLSPLGLDSDGVDGQVKRGSGNEDGEPLKSSSRGRRRRYSNGASGSGTGSGGTKIATRKSEKKENVVIQVKSDRMLYLFWLPILLFVGFWLLVSALPIATGFGLIYARKITRAIKQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA17</accession>
    <name>A0A1E3IA17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028491.1">
        <property type="nucleotide sequence ID" value="XM_019179545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA17"/>
    <dbReference type="GeneID" id="30196763"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26752" checksum="EF49483D0AFE7A3E" modified="2017-01-18" version="1">MSAFLKNLRHLLPFAKPKGLAGYDLQGNRYFELPNPMGGRLKRSVEYAINRDIAEYGRAELKPPVQWRAWLSHTRSDPPSRQELEKDLYRQNDLLPKIAAIEAREREERIRQGYLLPDGSEPEKSDVKQVTAPSEISGERRAQTQRFIDASNASRAGTKEAEAVWREKSAPASEVAPPRRTIDPTTASPEELRKLAEEDTKRRIAQTEGAPEVAKKGDVQSVRFGEGGLAPKRRGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB45</accession>
    <name>A0A1E3IB45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028564.1">
        <property type="nucleotide sequence ID" value="XM_019179423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB45"/>
    <dbReference type="GeneID" id="30196634"/>
    <dbReference type="OrthoDB" id="10298748at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="161" mass="18551" checksum="2E454321FC28581B" modified="2017-01-18" version="1">MFAQSFNPLYPQDSVSSYGDYDSTTTFKDQKRDIAELKEDVQVIKSQVTSIHASLRNHPRPSKTDHTVKIDSHFQEVVQIILGRIEVITDSHSANFARPILQALMRKNGELSKDDRLKLARVIGRFEHTCAYYEMTPDAKERYRMALIAMSIRDLRELLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBV0</accession>
    <name>A0A1E3IBV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028423.1">
        <property type="nucleotide sequence ID" value="XM_019179566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBV0"/>
    <dbReference type="GeneID" id="30196785"/>
    <dbReference type="OrthoDB" id="2586335at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="901" mass="96555" checksum="880BE3CD2AB5A7E1" modified="2017-01-18" version="1">MADPVSCPMTKSSKSSTSHSSSSFFPDNYSPTAPTSPASPSNTSSAGNPNPGQVPTALPTPMSFSGSRENAKGLELAPPLSVGAGEEGGRGDGPMISPNTEAIFTPARSPGHRTNCFPEPSPRSSTAPGAGGPASPRGSAHGAGPGLRGKASMSHMDTWMEDLSLSGNRGEKGKETEREKARKGKGYNTYESCMNGALGHDTKAATYKIGTEKAYHHLNRSNELFLLAMDFRINDKKALLGRSRILIQLASNYQPPRVATESLRDAVDMLRTLVGLAPHSLTARETLAEGCSLLSAILHETEDYIEDESRVWSGEIGELAREALAMLEDVAADRMDKMRAMSSNEAAQLSPDAAELFLKLSDAALKVSAFAMDLQGVELHIELAEQALDQASNMATVAATSRIKSSSATATLIARVQHASSKSSLERLRHTFTLGLPLDEEDFRALLADMEMLATESRARVAKARGSKAGSLATLAWETVKLVGDAEVLYANLLRGVWRNRKPRRRSGGVGKVGTPTRRTSTRDLVDAIREEDEPEEGQAKVVGPASAPAAWRIPGRRESASSNGSDGVSSRKGSAALGAAAEGAELLTFPNRGRFLSSVSVPATGRRGSWLPSPGDVALNRAQRRRSSLASPLSQSFTGLLPEPQTGHLNGLNIQRTRRASSTGGSLVLPDGQSAWSRRASVISLSSDDGSPSASISSSALARSAWQLLESAVHQYKIGLNILSSSALPNAELAKAKNETLVGIAYASLFMASLSPRLAVAAERRETFLVTAEVYTTWAAREVGWSFLIEGTKAAEMADRRTNSWRADEAGKRAVLLLVRIWWHRAVTTQAIDVETKRNAKDAVETVVKRMKEKEGTREGDVFRVRWWLSRQEGEIDTAEGLFWRSVCRILKGGPGFVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICP5</accession>
    <name>A0A1E3ICP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028547.1">
        <property type="nucleotide sequence ID" value="XM_019179509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICP5"/>
    <dbReference type="GeneID" id="30196726"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15120" checksum="A4F9F7AD2A6162D3" modified="2017-01-18" version="1">MTIHALWIISKAGGLVFSRSYSDVLPPLPVNTILTLAGILHGIHAITARLTPAPSPGQPIEGLDSFEAEGWGGKVFMTPTGTKFVVLHSIPHTGLEDLARRIYETYADTVMKNPFHTLEMPINSSLFDEKLGGLIGGVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFB0</accession>
    <name>A0A1E3IFB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028889.1">
        <property type="nucleotide sequence ID" value="XM_019179131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFB0"/>
    <dbReference type="GeneID" id="30196328"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129730" evidence="1">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="12"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="39288" checksum="C7DD84B37252E5DE" modified="2017-01-18" version="1">MLGFTASAVFGLVLAGAGVQASTPLVRSYEGDTFFDRWQYYGYYDNTTNGDAYYANKSVATGSPELTYLTDAGTAVIKVDNTSTVAYNEKRNTIRLTSEDTYSVGSVWVLDAVHLPYGCSVWPAFWSYGAGATWPEQGEIDTIEGVNMGYSNHMALHTEDGCSLEASSTQYSGTVNDTSCYYSDNDNSGCGVTDTDYNSYGSGFASNGGGAFVTEFSEDGISIWFFERSAIPDAVSNANDSIDTSSLGTPSAYWGSNTCDITEFFGDQSLVFDITLCGSWAGQSNILSTTGCSALSGSDTCYTTYVLDSTNYDTAYFEINYLKVYSNDSSSSNSSSSSSSSSSSSGVSATSALGWLLAGIMGASAFVGSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGI8</accession>
    <name>A0A1E3IGI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029046.1">
        <property type="nucleotide sequence ID" value="XM_019178952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGI8"/>
    <dbReference type="GeneID" id="30196140"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="506" mass="55640" checksum="3367A7176FE7F31A" modified="2017-01-18" version="1">MPTTLIRNAHLVGYPAGSTYSVFVKDGTVVSITETGSQEEEADEIIDVIDLDAQWISPSLIDWHTHTTLNALHSHRLDLQTAKSAQDVLDRVLDAFDDPKYSAVKGCRDFRGINMRNAGWPDPEVLTRQALDKISTKRPIYLFFNGYHSICANSVGLELGGYEPEGHSGYLFEHEAFAMARVIGKVDVDAMDEWVWDESRYAASLGVTEIVDLEWDLGIPNWQRRYAKGFRSLRVHVGMYTEHLQYSINLSLKTGDPVPNTNGLITVGPFKIVTDGSLGSQTAFCHDAYPGTPGNFGMKTYEPEELGVLVKRGADNGFRMAIHAIGDHANQLTLQTLARAEAILPGSTIEHAQLLSHSDLALFKSLGIIASIQPCHLVDDRDLCHKFWPGREGRAYAFRWMVDAGIPIKMGSDCPVAPLQPWEAMAVAITRAGAGDEENPFCKEQIIDLEVAWAASTSNGKSKLEVGDRADLLIISNDPLSCDAAGLRAMKVKGTMLGGDWTHKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGL6</accession>
    <name>A0A1E3IGL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029075.1">
        <property type="nucleotide sequence ID" value="XM_019178981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGL6"/>
    <dbReference type="GeneID" id="30196173"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129755" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="15"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="44803" checksum="EC15EC0B52B2E592" modified="2017-01-18" version="1">MLTLLSVLLVITRVPQTKATIYPLVESWHGDGFFDGFRFPAETYDNTTNGYTFWATAQNTSLLRTTSSGTTILAVDNTSSVAYDSKRYAPKLLSKSLFDVGTVWVMDAVHMPYGCSVWPAFWTQGANWPEGGEIDIMEGINNQVTNVIALHTSNTTTCTVDSSSTSSFSGTVENNDCNNSLNNGAGCTVKDENEKSYGAGFAEAGGGVYVGEYAEDWIRVWFITRADVPESLTVDASSLDTSTLGTPVAEYLASTCEIDKAFSPQTLTINIALCGDFAGIPALLEQTCPALVGDATCYTTYVINDQSTTYAQAYFEINYINVFSSNPSSVTTIGFSPSSSSSASESLAENTWTGAKTTTTSDVKIGPSDVTTTVKSGGWTTNAVGVPVPNGISSGAYARRVSWGGFVVMGVYIFLGFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHL8</accession>
    <name>A0A1E3IHL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029157.1">
        <property type="nucleotide sequence ID" value="XM_019178880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHL8"/>
    <dbReference type="GeneID" id="30196060"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="252"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="67757" checksum="B9C8F791307A8B00" modified="2017-01-18" version="1">MPFNDELDSPDFRAWLTKTIEPLCDADPAVLSDYIIALLKHDASMEEAEWKEFITKELIDFLEASSAPFVDTLFTALSTKAYNAAVPTPVPAPVATHPIPTGPAADIPQYHPQFPAAGPSSGAPAVEDVSMQDATAGVGKSGRPKCRDYHERGYCMRGANCQFEHSEDVLIPTPDMMFQGFFPPFMGMPPGFPGMPGMPPGLPQRGRGGPRGRGGHPGRGGYPPHGHGHGQRPEPDENFLGNREPPKDRNGNTLVVSDIPRQNLTVPSIKDYFSKFGEVTNVAIDAKSARALVSFTSNFEAYQAWKSDQAIFDNRHVKVLWHRPHPGQGAAGQKALEASRTLLENMKKIEAGEGGQKVPPKFSGPEQRLQAALAELEHRERQTKKEPLMAEQKILLARASKSTKEEKLTILKRLKAIAKEIEVLNNPPPKPEGMEIDETKAKLDQELAAHGMEQGSDEELVRLSSQLASLKEKANTYGISPRYSPYAPRGRGRGRGRGGRSVHTLDNRSRTIVVSGDNFADEGARKVAVDWYESTGGAVEVVEGSLRISYPQREMAEKALALGTDQIREQTGIIRTAWEAPQAPDVESYYQPVDVEMGAGASMGETGEEERRGERNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHW7</accession>
    <name>A0A1E3IHW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029196.1">
        <property type="nucleotide sequence ID" value="XM_019178919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHW7"/>
    <dbReference type="GeneID" id="30196104"/>
    <dbReference type="OrthoDB" id="683469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="15757" checksum="D8E88ED69E4A6047" modified="2017-01-18" version="1">MPRKLSVTILSERAPQPGVLAPRVGALRYQFREHQLQSSGVESETKSKTAISLVEQQTGVQMTQSSTRGKNVVTGIVNAKNLHWIPVGVFPQQKLIVTVYWAEGRFGAGSEFDEKFMNVWRERFAWERRRGLVDDAANQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II62</accession>
    <name>A0A1E3II62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028981.1">
        <property type="nucleotide sequence ID" value="XM_019179063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3II62"/>
    <dbReference type="GeneID" id="30196256"/>
    <dbReference type="OrthoDB" id="2569556at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="203" mass="22156" checksum="DFECCB583414A77C" modified="2017-01-18" version="1">MNRTTLSKALSRTPNLSRPSSSTSYAPPKKSTGRALSASTLRSLVSLHHSSAGFLHSPTELPVGFENAFRHTKPPAFETYEEFRRSVHATQALHPPGGMENLVEKGTVLDSCKAGVYTGTQKAFKRLPSAQGLVSETDGVKSSDRALSERQMRVKEAIYGTWERGGSGMNRAEPGLDGVLEYIEAKGKTVGEYAQEWEKRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJI6</accession>
    <name>A0A1E3IJI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029332.1">
        <property type="nucleotide sequence ID" value="XM_019178631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJI6"/>
    <dbReference type="GeneID" id="30195788"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="50191" checksum="A2BA3D125FCD269A" modified="2017-01-18" version="1">MSSYGPPRMIILSTAGGNDIFVRMPENYEKAMAATMERFNIPKETHYARLSVRAVDLPWMGGYAAKDRVYIADNDSYQYACTGKHFARFEVHVYAKTPMPSSSSSGSDKGDKKTEPKPAEVPLPAETSDMDVISAESELTCTTLKGRTTTAAGVVFGDVRVTRPGAYLGVLHINDNMTKQRFVGTQLRPDEVFTRCVPQDKNVCRVMFCPRSIRPGIKLLHPDEKNVEISYSIKDWSLASSYPTTTLNPDHSSKHRKRLRWYIRVHPSGMIEDLLTGTKSSNLFCELVPSSPTTAPAAPPKDLQAALVPAYPDLRPGNAWCLPLELFVPHLDRVLEDLGLEVECRTGMITSWLPGISRHGHIAYRILHRNQIDPTMKLTIIPPPSVLIRIFVLFKGISTAELPQWEKSGVAHAQSGLDWRDAVGWSRDLANETLFRVIEYGAMEVHAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJL3</accession>
    <name>A0A1E3IJL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029338.1">
        <property type="nucleotide sequence ID" value="XM_019178637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJL3"/>
    <dbReference type="GeneID" id="30195794"/>
    <dbReference type="OrthoDB" id="10340548at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="121" mass="13410" checksum="EAC0CFA6A7B59645" modified="2017-01-18" version="1">MPDSDEQTRLISEEATRVAERFMGTIDANMAASGFETPTFPESYDIVVKTVTDWVQTAIEAEVNEEHNENWKLEDSLTNVDVRARAIGLSVSGEVLVWNAKVDGDGWSLTIKTPLIELPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM79</accession>
    <name>A0A1E3IM79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin ear-binding coat-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029601.1">
        <property type="nucleotide sequence ID" value="XM_019178445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM79"/>
    <dbReference type="GeneID" id="30195594"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000403">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.125, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="8"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21525" checksum="A91ABD255545A868" modified="2017-01-18" version="1">MDTLTDEIEAVLFVAREVMVYQIPPQTTTAGHKAADWNVESFLWKGRLRVIDIGSRSELRLEDSSTGELFAQVVYVSPWNQVEPVLDSSRYFVLRVEGEGGKRAYIGMGFAERGEAFDFQVALQTVVKRTQNTTSISDDPEEPSKPAAPPKDYSLKEGQTFTINIPGRERKKPASSGGGGGGGLFALPPPPPPGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INI1</accession>
    <name>A0A1E3INI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029681.1">
        <property type="nucleotide sequence ID" value="XM_019178243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INI1"/>
    <dbReference type="GeneID" id="30195389"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="110" mass="12394" checksum="E5BFF3A0D171A2EF" modified="2017-01-18" version="1">MSSPILTPPNHSSPPYRSHAALTKSEEYLISNIPSAPSFQHIARERPGAMMLRATLPFRVQIPHPPSHLHHPVSWFREATHGKAPPRQPSSYTSRALDWDHGQGHRQDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ28</accession>
    <name>A0A1E3IQ28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029809.1">
        <property type="nucleotide sequence ID" value="XM_019178090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ28"/>
    <dbReference type="GeneID" id="30195235"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN90707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="219" mass="24302" checksum="50D47846A07C6E22" modified="2017-01-18" version="1">MYGDLALQLVTASHRTTLATTPQLPLPKYALPLILSICLETRQLGASITAIAENHGPMSLTQDRGLVCNLTVQHLAARRNKRCLLAYLMTRVGGIKERWWDAGGGLAYLLSPAASANVNPEADAPDLRSALSPQELDFMRGYNSLLLDYKSEFLDVLDLTAGIEKPPGELMVDVRVVKDAGEVFLDSGERVDFRKGQRFRLERSQVERLVIQGYLEEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQF4</accession>
    <name>A0A1E3IQF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029688.1">
        <property type="nucleotide sequence ID" value="XM_019178250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQF4"/>
    <dbReference type="GeneID" id="30195396"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="46611" checksum="03EEB3DAC211AEB5" modified="2017-01-18" version="1">MPHVREQEYKVPSEDCELQYVEVIQRHHKRTPYASNTFFKEDITWDCSNEGPYHYAKDRNGLQTAPVNWQAQTGTQNPFEYTVGPGSLNSTFRVSPLTLKCASLGNQWTGWSGKGMDFEESSKLLDAFYEAGGNFIDVANNYQDEQSEMVLGEWMEKRGIRDEIVVATKFTSYPLARKEGPFEDIAINYSGNSRKSLNLSLPSLKKLRTNYIDVFYVHYWDHTTSIPELMQSLNELVNSRKVLYLGISIPQISGWVVAHAKDYAIQHLLAQFVIYQVMWNVQIKKQANWRGGVPPTEAELKVSQELQEIAEELLGGVKLANVALAWSRHMVADVFPLIEGSSIEHPKANIEALKIKLTEAQVDKLNNAYPFDWGFPHNFLGIDPRYLPGGKPAPNAVHLINAGEIEYTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQM3</accession>
    <name>A0A1E3IQM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029827.1">
        <property type="nucleotide sequence ID" value="XM_019178108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195253"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1647"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1713"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1780"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2186"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2151"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1838"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1897"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2212" mass="238083" checksum="BAECB9C935EF58CE" modified="2017-01-18" version="1">MLHPPLSSPPQTAETTISAFTASTISSKLSFSNTALTTPDLGSPTKQKATLEPLLQVVERPEEESSRAGTPSDGGSVRSAGYDQKSQSSETRGLGISGGRKVKDVASRFEQMRSGHTPSPTPHERRPLTGPRRLPTRPASPLVTLPEPFKKKGMSSPLHSSSPVRPPIHRKNESKMSKESPYSGQRRTPLSVHTESNRMDSVSSMPVPSPLSPASTLRPPTYRTDDSGMVRENVHLGSRRMPLSIHTEPTRVLSSSSMATTRPIASTTTSRATENFPIAPSRRLPIPASFLDAPPTRNTPDHAPKETPTRLKRERGSTKKMIQKWETQTTISPTQAESLQNAQGLFTRDYLDKKPLPSPYPNSPINTPPRVPPTFTPSKSLRDPPPPLADGLSTSPSWLRTPIRSTHKHGDSLAVSPSRSQYCLSESPTGKKQKVSPLRAVSNFLGKKKGKGKERETRRDYGDIGVISEGEGRFGLVPQRDRMGSAEMRRSADFKPTIRSNPVIWLIETPYMPSSPWGDWLPSWAHLTSDSLSVTYCPVFSTPRNAHSGTASRISNNKSSTKSVPFSAITPPPLDTPADKVLHVMNCLDIKSLKKDDLKARGVPLAPDGNGGEVLEIVWENEVRSYLAVEGVDGRNAWLAAIRGIIPRTPILPPITPAETPFATISSPLRQASLPKVPSHRPSVGTLHGGETGFGSLQLVENEWVASRPLSGPLSGYGSSEHGSPRRPLPVPGPVKEDSPLRNSITRMFSERKFDTQEKEQAKLEDVFGMDETPMDIPKPFSHEKQRSSSQSSEVSQRIIDWQTPVQTERDLSVFARSRLPPIPTTEPFYPHIDEEDSGEHLDIPPSETMLSFDSDDLNPSRSASQVGRADTVIDGDGDEAEQEREKANGDVKSRAAMWESQTTEKDSSYISRVAFPKPNFDSPSSKAKVYTVGLVEHDMPTPLFFGKGGENDMAGAGASPSRTMQLALQDLPPARPISEFMTKPLNIHKEGPADSSTDTLVNTPGSPRTIVLGNLPPPADVSRVNTPSSRGSSMDSPITIVPLEKNIVHQTMNVPRRGPRPISTSTFGRRVSSGGKPSPHSADQQTTPPARVVTPAMVAQPSTSRDLAMGAVSSPSPASASDSLPSRGKSRRSLLNLPVPSLRSSSPSSLASEDSVVAPKSVRSELFGASVADLIRRGDTPSTPSPLSRPSSARPASAISRPSSTLARQGSGIKGQAGPVKVLTALFEPATSSDAPVVNSRPSSRSSGYVKKDMATTETEAPKVVPTAEDQYTARNERWEEPIGSISLPGRVPRGIHRPATTVPALLGADPGKGAFVAADLDQVPPLPTKDGSSPTSELVLAQMQVLTDRTREMSDPATAPYPTALREKLGALHQDLDLVKGLVTPAPITETTVVEAVHLQDKDVEPNASAMDLSRVYTHLENLEGRTSTLVDSETAPYPRALEARLNGLYEELAAVRRLIEEERLQQPQAVYMADVPLRSRHMPGGNLPYAGAAFSAQPQRGYDEGTATVAKHDVPVTSQLENDVPGEGEAAKFYKSLPEPPMEEHSSKAINNTPTRYSHASGAFNIPRRAVPSSAPTPKAATQAQNIPNTPAAVAPASPAASAHDATGLLPAAKVTEPAEVKNMTVSTGGDLQAEDSDAIMAGDVPAPPHRILNVTDRPRQRGPSPDSRPRPATLNMPAPLARQLTVREPSVDGQHPEPDVTARSVTTGDILTPTASHPPTIAEQNDKVNGRPGSAATIAMPVPYSPRPVAQPDMSEIHKKLDALTALYTQFVGTQKGAPVPDTAAPSDETRKVETNPVDQGVTGAIDNDRNPGLEAGDVHDKPSLPRLLTVMRRAVETPVADKPKENSSKKDKPDAKAVESETPKAEPSTKELGDAKTSGDKAAPTTTAGEANVRESEPKAVEHDEAAAAEEVAKIMGNEDGENKILKQQDVHIISTTPPAKDSAADPPTSIAPAIPEETLKQMDEAMEMLKGLNEAKDSQKIQAADMGKYLGELNAWLEKFVTGSSGHLQQMSGRLDTLFGPEPDQAGDAPTGLPALIADMHKMLVDQQGRNEAEGFMGQRLDSLVSMMGHDQKRQAVQEAATGQILHVLEKQRQDHEILLRAIATDLTEEIRGEKMKFLESMQKATTVNVMMHIEEFKRLLNVEVNKSMGELGKVREEKRALEQQIADLFALKAKHGFEPRGLPATPAAKSDKAAAKPPPPPPNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQP3</accession>
    <name>A0A1E3IQP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate dehydrogenase X component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029847.1">
        <property type="nucleotide sequence ID" value="XM_019178128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQP3"/>
    <dbReference type="GeneID" id="30195273"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="32328" checksum="044B2C77AD077042" modified="2017-01-18" version="1">MGMPAMSPTMTEGGVAEWKLKEGDSFAAGDVLLEVETDKATIDVEAQEDGILGKIIIQNGAKNVPVGQIIAILAEEGDDISNLEVPKEEASPSSSAPKEEKKEAASEQVKSEGRENPRDERKPHEHKEIKHPKPLFPSVSRLLQESSLTSEEISKLKGTGRHGMLTKGDVLVALGKIKNPYGSAEKLVTDAMGASGRRASENKLTEAKNAPGEGGEKKKEAPLDGAALRRLIVKGMSKVTQPAEPIVKHESTPLPRSDDFEFDAILAPYASLLPAPKPSVKLPSEDDLKAAAPKKDEFAGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRT7</accession>
    <name>A0A1E3IRT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029946.1">
        <property type="nucleotide sequence ID" value="XM_019177907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRT7"/>
    <dbReference type="GeneID" id="30195042"/>
    <dbReference type="OrthoDB" id="10290471at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="173" mass="19942" checksum="7F0E418655F7E353" modified="2017-01-18" version="1">MSTTRSASVKLAACSHTIITNPEEGDRYMAYKPVWKVKPVWAPGDEPNEDQMRNLASLADNISRSYWRSNWDNDWSRRDAPTNLSFCTIEAFEQQQGHLEYDTNDKLSVACDLAETDEGRRNATVIYPDFAAYSNTYPVTDYNNTLILDQAHMTADLEAMWSRHFSRYRVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS16</accession>
    <name>A0A1E3IS16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030030.1">
        <property type="nucleotide sequence ID" value="XM_019177991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS16"/>
    <dbReference type="GeneID" id="30195130"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN91404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="38856" checksum="6BF7A16E9909A454" modified="2017-01-18" version="1">MSWRVDGEGVLSRERGPGAKAQEEKEAWGAHDAPVTGWEVLVSQRLSVAGSRAIFYWLTKSPSISSTFLVLTMIVLAVLACIEKVSSIANLVSVEEDWVVVVAGDDSSTLAALNSQMRHIDLVCKLLGPLSIALLDGDSTKVAIGINLLMNITSVLVEYFAIAQVYSRDDDRLKLPKSVTSASRRPASKTKRPHPLSTKIRAVCGSSPPTPLVQDQPRPRPLPRRLVFAIYSERPFVAASGLVVRTILSHLGLRTLDSCTQIIVQELSLVLEVEPEIRGIFSSIESAWQNAFELLTYTSTIIFLRPDQFHYPVWLSVGAVATAILLFSNFVWHRRGHLLHPEKTAGICGCHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISC7</accession>
    <name>A0A1E3ISC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030098.1">
        <property type="nucleotide sequence ID" value="XM_019178059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISC7"/>
    <dbReference type="GeneID" id="30195204"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN91472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="130" mass="14112" checksum="D8D4AE651CAE2E00" modified="2017-01-18" version="1">MSKSPITCHGHGAYLLNTVLDASQGKPAAGVEVRLELVSLSGESTESSAKVLSSGATNSDGRCSDLLSSETKLQAGVYKMVFVTGPYFKATETKTFYPFVEITFNYEDPSQHYHIPLLLSPFSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISN5</accession>
    <name>A0A1E3ISN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase (Ubiquinone) Fe-S protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030091.1">
        <property type="nucleotide sequence ID" value="XM_019178052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISN5"/>
    <dbReference type="GeneID" id="30195194"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="106"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN91465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="32708" checksum="41BE9BF9AC72FE1D" modified="2017-01-18" version="1">MALVRSARPLLALRAARPAAPAPTRAFSSPAFLRQRTSPPTAHPSPSHPLAEQPSVPPYKEPVGVNPADRSSPVSTPLHEYGQYITSCLPKYIQQFSVYKDELVLYIPPSAVIPVFTFLRDHTQCQYRQISDITAVDFPTKLYRFEVVYNLLSVEHQSRIRVKTYADEVTPVPSLCGLYNGANWYEREVWDMFGVFFEGHPDLRRILTDYGFEGHPLRKDFPLTGYSEVRYDDEKKRVVYEPLQLTQAFRNFGDAASPWEQVGGGDPATQPEDYKIPPPPPPKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY25</accession>
    <name>A0A1E3IY25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030625.1">
        <property type="nucleotide sequence ID" value="XM_019177472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY25"/>
    <dbReference type="GeneID" id="30194598"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="83" mass="9650" checksum="5EEE490CE1165CE8" modified="2017-01-18" version="1">MSRARFIESSKFGFIRSRVNNCDWPDDYEMTQVPNTPNDVQALSRSEVETWFRHYGAEASDTAFQKEKLIAFMSGQDLDPRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY90</accession>
    <name>A0A1E3IY90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">L198_05445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030682.1">
        <property type="nucleotide sequence ID" value="XM_019177529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY90"/>
    <dbReference type="GeneID" id="30194658"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="490" mass="52929" checksum="62C291B367BDE266" modified="2017-01-18" version="1">MSGLPAAPGTSRQLPINLFTRSGTDAIPASTYFIPSDWRRFQLSELINNVLQNTPENGRKPVPFDFLVNGEVLRGSLESWAKKNRGGDEESSIDVEYVRSVMPPEEAGRVEVEDWVSGLSLGRNGYILLSSYLSHLQILPLANPSSTLYTLPLPTSLGATSCAWVSPSSQQRDILLAAGSVDRQTHVFSIPSLSPDETSTPREIYTLHGHTGPVSDVIASKSGSEIVSASWDGSVNLYALPNEEPTEHQLPADPTSYLPGQGTKKRRKLEKSREKDGEEKDKIEGLTDLDATGEGGWRRTPDITLRAHTGRVGALVWDKLNDAKLWSAGWDGSLREWDVQAGGVAGQVRQGPFDKSLLGVDMWAVNGVIATGSMDRTVCLWDTRQATSLISLTLPTTSPVPSVTCHPTSPFTLASATYSGLVQIWDIRSPKSPLFTVSKAANKAASGEARTVTKNGKVLGERLLSVDWDGDVLVAGGEDGEVGVWRARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J078</accession>
    <name>A0A1E3J078_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030821.1">
        <property type="nucleotide sequence ID" value="XM_019177240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J078"/>
    <dbReference type="GeneID" id="30194359"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="67420" checksum="79D77E2E779F2FCC" modified="2017-01-18" version="1">MSLYGGIKFTAPTAPQQQAEEQPSASSTPASTSATSDEPAKTTAPAQQAKTKSAAETSTALKFAPRINKKPSRPALPASAPVVIPHIGISSKPDIVRAAEPVLTRSESSGKVNNDNEDEVVLGQDGIPLAQAPSMTLDPKGRTLAGGGDRKRKNKKRKSQQQPQMPTFNPDEEYDPARPNDLGEYQDYRVRAKEERRRQFMEAKKRKADGLDSDESSCYSDSDEDYGPRRDAPKMFAPPKMYSPPSSKAPLVPPETSAPVAPPSAIPQSADEAYARRVAMSQPRVSSGGDDGYDQRPSFNQQRPTGSATSGDDAFARRVAMSQGLPQSNMPSFVSSSSSLPNNAPPSNPPNVFVPPAPAPAPPKPLDSQAVTSANDEPKDQKEFEATLAERKKAAEAIAAKFKNPKAYSWANAPPDASFSANVSLQDVEGGTFAEKMMRKMGHVEGSGLGARGEGIVHALTAEHVAPPTNINQPLSKRALAKQKAAAANTKNRKWVQSASSRGKIVNANEAKRATEERGQKGEEGRVICLRGMVGSEEEIDEDLADEIGEECSKHGIVERVLLHMVEPPPPEPEECLRVFVVFSGMAGAWKAQKELDGRFFAGRTIKATYFDEERFNRGERDGPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0L7</accession>
    <name>A0A1E3J0L7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear protein SNF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030726.1">
        <property type="nucleotide sequence ID" value="XM_019177145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0L7"/>
    <dbReference type="GeneID" id="30194259"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="412" mass="45252" checksum="1DDC4EBDE746DB6D" modified="2017-01-18" version="1">MDSALSTSQSATSSRPTRRPSTSARRPSAATHRPPPPPRPLTHDEALDSLRAFLKERSSYDVFPVSFRLIVLDTHLKVKKALDVMLLYGVVSAPLWNTAAAQFAGMFTVQDVIHLIQYYYQSSSWEGATADVEQFRLQSIRDIEKILHVPPPPLLYVHPLRPLYDACRYLIRTHARRLPLIDKDPQTGGEVVISVLTQYRVLKFIAMNCRDITQYLTASVHQLGIGTYVSPNPDPESTNKFYPLATATMKTTVFDVVHLFSEQGISAVPIVDDQGKVLNLYETVDVITLVRNGAYTSLDLTIAQALKQRAVDFPGVVTCSPNDSLSAIFSLIKIRRVHRLVVVAGQDDPKPGRLVGVISLSDIMRALIGSDVPLGSAGVGAKVVDKVLREEGEDEVFATSEGTRSGGTSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1E2</accession>
    <name>A0A1E3J1E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030966.1">
        <property type="nucleotide sequence ID" value="XM_019176934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1E2"/>
    <dbReference type="GeneID" id="30194041"/>
    <dbReference type="OrthoDB" id="10322347at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38279" checksum="329D944C6853E2E9" modified="2017-01-18" version="1">MPLPRTRAITRESNGLLAGLPSLPAELIQMIFDYVLLFSQTDKSLAFRLMCTSKYLANTISPALYRHVSLNARNASTFFYGLDGKLKRGENRRWRSGNLEGKSSAVRRAMWLSMVRRVEIQDLKGLEACVDASAIICKHDEESRRKALKSHREGFLFFGDCHPANKDEEAVLLLGSSLCEQLKSTSHFDRQAHSHLVHQHILYIDLPPKHYPGSVRHFLFPTDRYRNSFVLLNYTAYEQAWFLDWLVDTTATIAGKYFRLALHKLEQNPEGIALGVAYTLARSCTKRNFAILIENYTFKEGETSGSIEERMMTHFDEHRGWKGAARDLGITFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Q2</accession>
    <name>A0A1E3J1Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031076.1">
        <property type="nucleotide sequence ID" value="XM_019177044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Q2"/>
    <dbReference type="GeneID" id="30194155"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="50160" checksum="B97E9F74E690ECBF" modified="2017-01-18" version="1">MSNKRSAPSSSSTQKRTRFAPAPSVSGPSASASRSASGQNTPLSQTEDDDDAFLQDDIVSNARTAKSKAKSRVDQSAYASDSSGDEDEDEDGEGAGGGEKKKEGEDDDVDMFAEDVQEEKKEKKKKEFMDLNDIKGQEFERPSAPGKGKGPAEDSDSEAEEPSKTGLDGDMGVDITPFNMKNEMNEGRFTADGETYVENDDDPEAKYDVWMNDVDKEGMKKARRAHKEQERLEQERQAQESGGGEEKERRERELLRAAWELMQRGETILETLQRLGKEVEDERRKREKEAGQKKKSWAEKQKERKALMAAEEEQKDSIHTSNPFTNLSNIVSGLTTIGHLDVYSLSRESIQRMLPAAPSNDVGEQRSAPPKPKVDNRQFQYRFSLAYVRNLPEGQRPVEREAFGMFSLLQLRGWKATGFFGGPNCENVELRVVGEDGVPGPWGSWAEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1U0</accession>
    <name>A0A1E3J1U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynein intermediate chain, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031129.1">
        <property type="nucleotide sequence ID" value="XM_019177097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1U0"/>
    <dbReference type="GeneID" id="30194211"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="516"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="78415" checksum="CA8F8747BA11FB37" modified="2017-01-18" version="1">MSDRRRQEIEEKRAKLAELRRARDERKQLLANTDQASEPMATNRRDVNDLVDSLLTRPASPFTPAPSSRPSAFGTPGRPSGSTPPSSIPGTPGGRASRLSNEGSSGRATGPTAGMGMTGLPSGADRYHLSVLTGGCTDSGLRDSMMSPFSRPATDFVDHQEELFELPTKPAPVTYSKGIQTMVSSFAADVNFDDDYISDTEEERQRKRNLRDGETGRETEDEMRKRILEELEEERKALENELKEQGAELSDEQRQAVFAAPDFSSFIEQSTRITQRALSDGYDYIKDYTIGGDGAFDESEGVKVKLFCAFSDERWTNGRSVTDVDWSPKAKLSAASYNRNPSAVNDPDGIVAVWNLHLLERPEFIFHSPSDVLSVTFSPYHPTLIFGGSYSGQVLLWDTRAKHLPVLKTPLSATGHTYPIYDMKMVGTQNANNLISSSTDGLVCSWLADMLAQPQETLPLTMPSHNKTDEVSITTFDFPDNETSTFWIGTEEGSVYQANRYDRASAKAGSNTEDIYKGHAAPVTGLHFHPGTGSIDFSDLFLTSSIDWTVKLWRTKAAATAATAKGTTGSGVQGGKGEDRVVPPMHSFEEAGDYVFDVKWHPHHPAVFGSVDGTGKFDLWNINQDVEVPITSTQVSPRAINKLAWDRTPTSRKAALGSSDGKVYVYDVAEKLVLPRDGEWVEMQKTVQGMAAAREVGGAGVFGGEAGMGAGKYDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1W0</accession>
    <name>A0A1E3J1W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031097.1">
        <property type="nucleotide sequence ID" value="XM_019177065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1W0"/>
    <dbReference type="GeneID" id="30194178"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="480"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109959" checksum="B8FBC0420A3F0A42" modified="2017-01-18" version="1">MKRTWEQPPQGDAPWVHLPAHPYAQAYFTPSPLHTSTTYHPAAPQPAHNKRQKTDTKKHSPTKDPDSEGDPDDPDDDDEDDPEDDGKPDKGKGANGKGAKGADGKPKQKLTRGSRACIACRKIKMRCIPDDSSAGQGNGICKRCKAGGHECIFEESNRGKRSTRKNEALAAKVSKMEAALKNIGLVLSNVDPSTLNSFNSALRSATDDQDVISMITAHASSRAAQRMTAGQRGAFSGHDHEGGHQPPLSPRLHSLPDNVLSPLGLLAEASLQNDTSKRKLIDSTGAGRSISRPHSAEHLQPPRNGSINLNGASTFRMATSDVRGGGEGHDEDDQLGQHGLGVSSHNYFKPGTGNVSFLPNLPAENRLPELLAIATREEIGELFDIFFDNMGSHVPLVYKEFHTPDLVLQRSQFLCTVICAIAARFYHKKPELHHSLSAYAKRLAFEVPSRGYKSVEVVQAYLLLSLWTLGPEKTFEQDRTWLMLGMAIRMATDLNLHRKSIMSGLDTEEGRARDLEIINRERCWLHCFVLDRSLSAQMGKPYSLKEDYIIRSSCEATWAQQAYSLPSDAALSAYVMLQQIMSRAIDSIYSSTTTVSGLRDDCDYMMIVRSAHEELRRWLSDFSRSMDNGGGTSEWSSRANFYFAYSSLVLYSFGLENALERAKMDISFFLTNVYEAATKVCTVVKEEFMPRGWLPYLPDTNFVMCSYALLSLLKLLKPELRPYHDSEDAIFKLVSELADVLEECAVDPSHQPAIYAAFIREIVRKTKELRHGGAGTVPSSPGHHGQGHGQGQHAIAAHMTHLAASQAASMAVLNEAGSAAAAGDNAHGHQDGNVDGQHHFDPSLMGQGANWHHDVLSGQETQFTFIPQGGDMLILPSQAGPSIAPSPTSAFLANPGSSQSNANPGSAPSSGGNMPAAGQSQGGTGTTPHFGTPSANGWAEYMPTFMSSDGFDGWDGSMLLPGFGRGQITLSGGLLHSQYGSGIMTPLHQTPLQSRIGSRAGSRAQSPHHDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J265</accession>
    <name>A0A1E3J265_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translational machinery component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031034.1">
        <property type="nucleotide sequence ID" value="XM_019177002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J265"/>
    <dbReference type="GeneID" id="30194112"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30980" checksum="C5A5DBE9F0009A75" modified="2017-01-18" version="1">MASIIRSTFSAPRAPLSFARARSAVPAASFSTSRARLNTPKTTPAEEAVLEPFPSSEAESPADRSMSSHQTPSSSTPKPDVVPNHQVLPKRTPLPSATASSSTPAASAAARKPSHIPQINSAATHRPGTQKSPYAGLRWTPEPVTFSYPSFSNNAEHAVPTHTLHIRSTRNNVLMTLTDGLGPLFGTVSAGSDKTFKNAQRSTYEAAAQASIKMFDRVVEWSREASGGSRSKEPKIRLSYNGLFGSAKEAVTTTLSGPQGAELRKLLVRVEDRTKIKIGGVRARKPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4A2</accession>
    <name>A0A1E3J4A2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031070.1">
        <property type="nucleotide sequence ID" value="XM_019177038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4A2"/>
    <dbReference type="GeneID" id="30194148"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="534" mass="57067" checksum="50F4999DD35AC360" modified="2017-01-18" version="1">MLPLLRRPLPLRTLASVAFARPSSSLSPLALKAAEDVNKWKGTTANGGKTKNYIGGEFVDSKADKWIEVRDPSSQTLINTVPETTADEFKQAVDAASQAFKTWSQTSIMRRQRAMFELQHLIRQHAPEIANSIVLEQGKTYADALGDVGRGLQVVETATAITSTLLGDKLEVAKDMDTYSRRLPLGVTAAITPFNFPAMIVLWSAALATVTGNTLIVKPSERDPGATMIIAELCERAGLPPGVINVVHGSAPTVNRICDDPAIKAISFVGGDKAGEHIYNRAIPLGKRVQANLGAKNHAIIMPDANQNLALNSVAGAAFGAAGQRCMALSIAIFVGTARDMIPDLVERAKGMKVSGGFEENTDLQEHIESLISSVETEGGKILLDGRGYSVPEYPNGNFVGPTIVEAVTTMQAYKTEIFGPVLTIVAADTLDDAIAIINENKYGNGASIFTNSGATARKFEIEAQPGQIGINVAIPVPLPMFNWSGNKGSFKGDISFYGKSGLDFYTQRKTTTSLWPEADAIGNRASGNMPQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4D0</accession>
    <name>A0A1E3J4D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031369.1">
        <property type="nucleotide sequence ID" value="XM_019176441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4D0"/>
    <dbReference type="GeneID" id="30193535"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="19812" checksum="65F31FC6C851B360" modified="2017-01-18" version="1">MAVFQQALAPFSLKGFYLLTWGTALGANVYKSLAAYKTYRVLPRQTFGTLQSQLTSTYFSFSSLTTSALLFTHLYFHPSLISSPRVPPHWLTSEEGRQGLFIIAGLVPQLLNWLVVGPLASSSVFERARLERVDGKDYDAENPSDKMAANNTKFATYHTISTALDTVSLLALGALGLAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4E8</accession>
    <name>A0A1E3J4E8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031387.1">
        <property type="nucleotide sequence ID" value="XM_019176459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4E8"/>
    <dbReference type="GeneID" id="30193553"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="37658" checksum="11EC154041AD8157" modified="2017-01-18" version="1">MSDSTGFGSGGSTSVLTVGSSDESSCLPSSVNADFYFSISPDSNPSACSSMSVTWPSNTTDPTHLYGIIPHGSAWEIPIDDSGTSQDWTVNIASGTQFLLLMSDAGQYQTGGSTDLYTVQSGSTDCLGNDSPTSASGGTTSTSSASGSTASVSGVGGSSSGGSDDSSSGSSSSNHTGAIVGGTVGGVAFVVLLSLIFFFFIRRQTRRKADAEDIAAKPYSVTHEKAKRRRTVDLGSGDEQEAEERNVEGEVYQLSPFRYPSPPGNVAPGAVPETAPRPTQEGKIQPFVAPSSTRPSIESTAAASPPEQSAQGSSEVERRASTRKTAPTASANALAAASNHENRQSVVAEETERRLMQHEDAGQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J506</accession>
    <name>A0A1E3J506_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031390.1">
        <property type="nucleotide sequence ID" value="XM_019176462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J506"/>
    <dbReference type="GeneID" id="30193556"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="23028" checksum="54B44D0D4F24BBEC" modified="2017-01-18" version="1">MNRIFGSGRAKPKPSLTDAIGSTETRISSLEVKLKKLDAELGVFKGQMSKMREGPGKAAVQQRALRVLKQKKMYEGQLGQLQQQTFNMEQAAMTTENLKNTMATVDAMKVANKEMKKQYKGIDIDKIENIHYDMEDLIDQANEIQESLGRSYGVPDEVDEADLMAELDAIGLDDEPIGDNETPSYLSDAQTLPDFVDSAPLEDFVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5A5</accession>
    <name>A0A1E3J5A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mps1 binder</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031490.1">
        <property type="nucleotide sequence ID" value="XM_019176562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5A5"/>
    <dbReference type="GeneID" id="30193656"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="253" mass="28886" checksum="1F31ABDCF80E64EC" modified="2017-01-18" version="1">MSGFLNSIGRLRAPKRSPTNTPTQQGFFDPLPSPGVETTQQNSQQPPSPGPKPLYLCQPFVKAALVKGSFKTIVAPPKYVDVNEWVAINLFDFYHNLNQFYGVLTEFCTIHNCPTMSGGRTLNFLWPDQNQRLVSLPAPTYIDFVMSWLQKLLDDENVFPTKSSKPFDHSFAYTAKHIYKHLFRIFAHLYHAHFEQILHLSIEAHFNSLFAHFLAFGKEFDLLVMKDLMTTQGMGQGVAELSEKWRQMGILET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J681</accession>
    <name>A0A1E3J681_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031616.1">
        <property type="nucleotide sequence ID" value="XM_019176206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J681"/>
    <dbReference type="GeneID" id="30193297"/>
    <dbReference type="OrthoDB" id="2564094at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="40952" checksum="6701CBACFEE706B6" modified="2017-01-18" version="1">MSPIPIILHFAPSASPRAPVSFSYALPSSAPSTSDAANTAASTSSRRKATRARVLAPGAKHATFTPLHRPIINRCIAYTASLSSSSAEHGAHPSTGHPYSPSSDWGNTRSFNPSDLEVIRDEKPKKRLNKAQMREKKANEDKVKRLVRELKGETVDDEGSLPDILEQTPTPSVQGESYEEPVSVKGQNDLAPVAGEEPDEKNEEHGTALPTPIQTAPLAKRTTLKRTRSFNNLVQQGNGVHAASPLRAVIGANGYEANNDQPPAKQLRRTSISHLESPRRDERRAYTHSPSGSAPEPLPESARSPRTVPLPAGVLQPSRTRNSRATSATLASVAGESSGMRRAISNVLPASGRSASVGSDGARERSRREVTLPNRLKDYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6H0</accession>
    <name>A0A1E3J6H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031709.1">
        <property type="nucleotide sequence ID" value="XM_019176299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6H0"/>
    <dbReference type="GeneID" id="30193390"/>
    <dbReference type="OrthoDB" id="2596228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="29591" checksum="240722F307B224CA" modified="2017-01-18" version="1">MDRNFDETFDEDDSLFSVSGPSNNPRPLYSTPPAPAGHGSRYAQHLTPPGPGVFISGRYPPVLSSPIVEGDSSMAYYPNTSGLQPGIDRSWARNHGSTGQDEEDEDEEEPSTAMTGIAAAGDETFDEEEAGDDEAGSDGSSEQYDPEGDPETFAKRLDELAGVLERGEVEAGELKWGPVITRGAGKMSKTSNSDLKAVINHHLSTTAWQYSSSALTPFPDPNHFDTFDSLTAHVDFVGAHPIRVLGQNWSDRDVLFEMGLLGLDAGGGGSSAPERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6L1</accession>
    <name>A0A1E3J6L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031746.1">
        <property type="nucleotide sequence ID" value="XM_019176336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6L1"/>
    <dbReference type="GeneID" id="30193427"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="332" mass="35264" checksum="F18B065FE5B0607C" modified="2017-01-18" version="1">MPLPADLLREKIERIPNPPIGHVAANSFIPPAQPVTDGKQLPTSNPLPILPAVEAAKRLAAYAAVDRHVIGVGSGSTVPYVVDRILAQGFEVNKDRVFLPTGFQSKELIVKAGLTLGDVDQYARIDVTIDGADEVDNELNSIKGGGACQLREKVLAEAADTWVIVADYRKNSETLGTEWTKGIPIEVVPFAYAKVLTNLANMGSPHVLANGEPGLTLRMGKMKAGPVVSDNGNFIIDAPFSSEEMSEPESLLHRIKMLTGVVEVGLFCGMARAAYFGNEDGSVSVRSNDGSVTRLGSSGTSTPSAELIPIIEREARAKAEANRQSVAKANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z6</accession>
    <name>A0A1E3J8Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031945.1">
        <property type="nucleotide sequence ID" value="XM_019176032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z6"/>
    <dbReference type="GeneID" id="30193119"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9834" checksum="8A3A7681C62152D2" modified="2017-01-18" version="1">MSAPAPIPALDEASKKELETFLEQEQAKAKLQASIHELTNTCWNTCITGSISSKFSKSEAQCLENCVDRFLDSSLYIVRQIEAQKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J924</accession>
    <name>A0A1E3J924_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031677.1">
        <property type="nucleotide sequence ID" value="XM_019176267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J924"/>
    <dbReference type="GeneID" id="30193358"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="183"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN96431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="628" mass="68426" checksum="93B36537740AAB78" modified="2017-01-18" version="1">MAADMDLVVLIDDSGAKLDPGNFVESMAVLLERETNFNVKPLPRARIPILKLELAPSSALPFGIACDIGIENRLAIENTRLLLTYATIDPARVRTLVLFLKVWSKRRRINSPYRGTLSSYGFTLMVLYFLVHVKQPPVLPNLQRIMPMRPLEEDEVMLEGRNVYFFDDVETLRREWSSVNFESVGELLVDFFRYFSHDFQFNNSVLSLRAGQLTKESKGWVNDIDVGGLNEMARDRNRLCIEDPFEISYNVARTVTKDGLYTIRGEFMRATRILTQRPDRAVLALAELCREREDELQRAPRSSSPAPRALSANRGNFSNSHAQGQWRSQSQTSYDRLGAGVHESRGLRSGEDLSEYSAQDLWLHSQGTSLGGVQTLNEDVDARGSRGRDTVARGLDTAGGSHRGSPSTRRSTSAYADGGGLTTTGTVSAPLSPQRLYAQLELGKGASVNQQQMWAGYDPRLHASAGMPLGVSGPSGLRSQSQQGTSRALSGLASRPLSSFATSTGILPTPAGAKGLHATTHLPAFSPFDADPVTPAPVSIHVESLHTGPSTAPLRQPSVHLTGSDVPAEFISPSTLLSPVPRVTTLPESRNGTPEVDYLVHSMRSVSVDTSGDPGSREKSGSDCPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J977</accession>
    <name>A0A1E3J977_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032015.1">
        <property type="nucleotide sequence ID" value="XM_019176102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J977"/>
    <dbReference type="GeneID" id="30193190"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000571">
        <property type="entry name" value="Guanine nucleotide-binding protein-like NSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="88"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="679" mass="73919" checksum="BDF77568E954FD7F" modified="2017-01-18" version="1">MPKPNKGGNRKVFALPTAQKKKGLDVPKFQTKINNAKQARPTPASLAALAANQSDIDISASSFDLGNVTFHEPIDSSLTRDSSSKAFMRELRKVIERSDVIIQVLDARDPEGTRSRWVEEEVRKRDMQGKKLLAVVNKIDLVPRANLEAWLKHLRHSFATMPFKSSTQNQRQNLSQNSVLLSQPTTVPGQQAVYSELPQTSSSLGAPALLHLLKQYALSTPHSSLTVGVVGYPNVGKSSMINSLKRSRACAVAAMPGKTRVVQEVVLDKGVKILDCPGVVLEDIGIHQEGEEGRRKQAEIMLRNCVKAELVDDPIAPVEVILNKVDSAQLEKLYNIPPYENVRDFLIRIALTRGRLGKGGVPDLEASAVQVLRDWNSGRIQYHTVPPKFHPSSAPAPQTAASAAPAAGDGMQDEAMGDAVEKVGDAKILNSLSEAFTLDGLFDNLGDEAAWEGDEVVEEEPIAEDPEIVVPEPAVAPVAAPAPAQPTKPRLSSKRAFVDSSDEESDADSDDSSFRPRPRVLPTATTVEPAAAAAAVAPALRYPVQPSHAQANKLFTPEELLVLPPSLSGKKAKKDAKKAKKRKAAVERTEGELMAGFMEMDMEEQRDDDGAGLSTVSGLNQRSKKDKRREKKEAQDKQRREQKKAQEEMEVEANPEIRQEADLANFLANMGAEGSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J998</accession>
    <name>A0A1E3J998_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032036.1">
        <property type="nucleotide sequence ID" value="XM_019176123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J998"/>
    <dbReference type="GeneID" id="30193211"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="30074" checksum="E3E13BDC77CE8A8C" modified="2017-01-18" version="1">MAHSSSVCYTTCFQLLNEDLQSSVGKIGRTLDSRSSSISLGEFGVHRASPQKQTLTRHRHFGPLQKHPVQPRPATETEIAVIYQSAADVRRINYWGDRPPGVTFFGVLENQGWSGGDSIMSDSVQVFARLSPVMQNVLIGLEGVHSSNALTKKAKEDGTALRREAVNTLHPLITKHPVTGDKILFVNEVFTTSVNGMKKEESENLLKFLFNYVARAADIQARVKWEEGTVVVWDQRRAQHTALLDTPPGKRRHMIRITPLAGKPIPATKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBI7</accession>
    <name>A0A1E3JBI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box and WD-40 domain-containing protein MET30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031883.1">
        <property type="nucleotide sequence ID" value="XM_019175970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBI7"/>
    <dbReference type="GeneID" id="30193057"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000987">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF681">
        <property type="entry name" value="F-BOX PROTEIN MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="680"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="772" mass="85211" checksum="96D7DF1807143848" modified="2017-01-18" version="1">MNHASASSSLPAYAETPNSMSSLSERELDVIPSRSGRKLCVRHKQMADQNMNEKLQHSLDNLSPSERAAITQMWSTFSTAPHGKRKIILEGILTMCCLQLSHLSDSLVQIIRIDPFSLLPREISLRILGFLDAFSLGKAAQVSKLWKALADDDLLWRRMCGQHIDRKCEKCGWGLPLLERKRLRVELKDRSPAELVEHNHSHDHEDGESRLVTRDQVLSGAYDHLSPGQVGLKSCDSPAMYLPSPSGTSVPSSKRPAPDSALAVSHASSKKAKFDNTDSGSDLRGRSSNGNDAGGLTREVRLTRPWKTVYCERLMVERNWRKGRCNTKVLKGHADGVTCLQYHTALTNPSYPVLITGSYDRTARVWNLESGEEVRVLRGHTHAVRALQFDQMLLFTGAMDGTVRMWNWRAGECLRVLDGHTDGVVTLNYNGYLLASGSADTTIQVWNFRTGNKFVLRGHEEWVNSVVLWDGKTSPSDTDPAAMPSFTQAVSNRCQKSSTPGLEISQPDVPNVEPGTMLFSASDDMTIKLWDLETATCVRTFEGHKAQVQSLKILMVDMTEEEVATRDRRQRRQLTPPHTTSGFITASNASPVGVHASGEVNGTLLDAAPDGFDPVEHRGRDREQTVQPRVYVHSPEGRSKRASSRDNSRADEKKAIITSGSLDGTVKIWDVETGQEQSTLFGHIEGVWAVDIDALRLVSASHDRTIKVWDRESAQCVQTLVGHRGAVTSCQLSDDMIVSGSDDGDIMAWNFAPAANNNHSNLASSSSTPGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBM1</accession>
    <name>A0A1E3JBM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031913.1">
        <property type="nucleotide sequence ID" value="XM_019176000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBM1"/>
    <dbReference type="GeneID" id="30193087"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114904" checksum="DDB8B9A2FBB44611" modified="2017-01-18" version="1">MAHLQAPTRINPEEVIPLSPPIRPPFVQYSSSPLPPTPHTPYSPAPLQQRPTSMPLRPYLALLPRIILTFCSPCLLPMILTIAHLIQNRSSTASLASSLKSSLLSACSGLAKGAASVQAIPRYLAMQTNQEAVRATQATILAVGTMLMDAIQIIEAVVNFIVDTYRSLLLCTIELAISDSVTSTLNSVRTDIQDDISSANNIIQSAVSGINTVTNLVNVNLTVPSFTIPSLSFLANVTIPTTFEDGLLTLNSSLPTLNDLKEKMNEIIDTPFELLISEINSTRLEMAASFNSSILPVPSLSSLSASSGNDLSNELCSDLDTSLIDDTAKALHKLSSIAIGLMFLLLFLVWAALAIWEWRKWKIMKDTVETIQEEWQHDGRSDAWRMVAIVEHPVLERYSSHVLNRVSKSPRTRTNIRWFMSYLAHPTCLALLFISIIGFLSIQFQLLALNAIKSNADSNANATVTASSNALVAKLNAAALNSSQEYADSYNTAIKEFEDRINNELFGSWVNTTAVTLNTTLVQFYDDVESILNTTFGDTILYNPINTFMYCILGSKITNLEKGLTWISEHAFVDLPTLSSDVLLLSNGSMEEIATPIASAAVGSSDDDDDDGVVGTLITHFESALKVERVFYGIMLAFWLLLFLIGLIIVIWYSGGKDKYMALRGMPPTGPDGFGQSGQDIKQQPKWKGWMTNDHPIYESYAEKQFRGTSPSPGGAPNLVVPSYDLPHSNDEKSFFRHVPDSRHGDPTLGRQSSGVRNTLASLAAPGQSFLKLTGRKLTGTPTPAEDEVPFVAGQSSELYSRDHANSPFPRQNSVSSDRPNSPQPFWVDKFYGAVEGVRAFFPTRGQKHGAALRRSASQRTEKSFGASQVPTARTPRYDWANEAKKKNEPEWTMVDAELYGRDIDGEPGRYPAIHSHEESNASDGAHAVYPRPMSRAPTLGEGMSALLNTPFRDQPPLPAGEQHDSVDYLEEYNSTHSEHEHFRDVASPTSSSMSYFAAEPQLASASKVQVDLGTGSGHATTALAEIMRELQERRDREGPFSDPHGGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC41</accession>
    <name>A0A1E3JC41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032274.1">
        <property type="nucleotide sequence ID" value="XM_019175784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC41"/>
    <dbReference type="GeneID" id="30192869"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="531" mass="56305" checksum="B46D10CEF9661239" modified="2017-01-18" version="1">MGLVDKEGVLQQLAASNTFDTDWPTLRSYFESSLEDALRLFLDKGPTRPYRPPGASPPEPVSQGSVTRTETSSPASENPKPPSDTLLLSPSQSTSIIEPVYEENLQPSTPGGLVVPPFPPIDRSRRRGPSPLMVVRANGIPSQRIAGSALETLDDRSWEEETAIGGRKLVGWLDEEKGKKEVDRMRALLGEMEEPPFTIQRLAELFLHPTSQHSSLGKFIRAIEKSLLVTTPWEAPSYDYVPPTTFPEHVGGSSSLSSYSSPVSNSSSSFDADTTVPPGSTTPLFSPIPFLVRPSLDPAAASTSESGQLATTSNESAEGLMSPLLISEEKANFSARSPTPEPEESNAEAIRKSDEAADLDTEMTPLSPEPADIPRPSAPGPLNDPTSPTAPSVDPGITSYLGRVDELDTGPIPTDSLEDAGVKRRASNASSVKANLEAELDRGNMVGGQGEGGNLAPHGMSEKPVPLSSTTVVPEEGAASGGEGRAIKGLRRSESERDLRERFVSGGVQESEGGDVDGGAKEDDGETSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCF3</accession>
    <name>A0A1E3JCF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid aminotransferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032401.1">
        <property type="nucleotide sequence ID" value="XM_019175911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCF3"/>
    <dbReference type="GeneID" id="30192998"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="133"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="579" mass="65235" checksum="E288B0946881A56D" modified="2017-01-18" version="1">MDSSFAIPAQHNAHTTSRLPDAQDMTRHLNRLAKHREANALKELYKYMAVPGMITMAGGIPHPEVFPFETISATIYQYNAFPLNPPRTPEKEKKSLLSWLFPSKAESPTVSFTIPKYASGATNPLTIELSTSLQYQSATGPPALPLFLREYVSKVYKPAYADWDVLINVGATDGWGKICAMLLEVGDAILVEEWTYPGAENTFVPYEVERVPIKMDGEGLLPGHLEDVLGNWDEETRGKRRPHVLYTIPTGQNPTGATMQAERKQEIYKICQKYDVVICEDEPYYCLYTGEWTPKDTKHERSIVAQRQIEAEMKEGSEGNQAFIDALPPSFLAFDTDGRVIRMDTFSKTSAPGSRLGWITSSPLFIERLTRATEATTQAPSGFATALTASMIQQWGFEGYIRWLRGIKALYNMRKTWLCDIFQEVFHLEFNESSSLFPERSRTVTCYSKRTQNAWDEKTGKRSRALVTFIPPTGIPADTSIAGMFIFLGVHFKEHPDYHALSQQGEDATLTLTKKLWELLADNLVLFAPGWGFDAGGEHAIGGKGFGYYRLAFSVATHKEFHDGITRFSEVLHQFFRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JES2</accession>
    <name>A0A1E3JES2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032446.1">
        <property type="nucleotide sequence ID" value="XM_019175343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JES2"/>
    <dbReference type="GeneID" id="30192424"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000361">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58144" checksum="1D014E957FD5BC3F" modified="2017-01-18" version="1">MADIMEKQEAAHIEDTIRDDKTHSDAVIEKVRQEHGEIYAQALERYGEEGSIDPETDKKLRNKLDRRIIPLLGICYFFYYVDKTTLSYAAIFGIRTDLNLIGDKYSWLSSIFYFGWLGWAIPSNLIMQRSPPAYYLAINIFFWGVFLMIQAASKNYATIAALRVISGAAEAIADPGFMLITSMYYTREEQPSRISSWYAFNGLGVAGGGLIGYGIGQIKGALASWRYEFLIAGAACSSWAICIGLYLPNSPVSFKGFTHDERVLMIARMRKNQRGIEGRKIKWDQILEAVTDYKTSSLIAHKAIHSLPLFTGISNFSTLVIQGLGFDTLHTALLGIPQGVLIMIWIGSGALINDRLPKNSRTFVCAAFMIPTIAGSLGFLLAPTNAYVGRLICFYLTGSYQSSFVLSLSLITSNSGGQSKKLIVSGFIWLGACVGNIAGPFFYKSEQAPKYTLGIGSILVCNCLEFLLFFAFRYAFKWENHKKQKLREQVRDSGEVTEEDVNATAFSDLTDKQNPNFEYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF02</accession>
    <name>A0A1E3JF02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SEL1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032537.1">
        <property type="nucleotide sequence ID" value="XM_019175434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF02"/>
    <dbReference type="GeneID" id="30192517"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130309" evidence="4">
        <location>
            <begin position="19"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN99460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="874" mass="96590" checksum="CE4B5D44139D6EFC" modified="2017-01-18" version="1">MRTAHLLLALAGVSLALSEQPSLCSPLTEAERILESLQPSPDAHLHSKAAGIVPFSNEGWADGLGWRQNGPLSTAFRLLPRVVSAFSPSRLLSSTAETMARSSEKKVSRGRRERIEKITDLIDEAEKNGCSEALMLKAEMGMFPPRGLKQDLQMAYESLQKYLEQSSDPEAQFLVGVFHATGLGGVSIDQGKALLYYTFAASQGHRPAAMALGYRHWAGIGVKEDCEVALEHYSNAAEISYRRFQEGPPGGLALPLVSSRLSDRVGGIYGTYASWASTGANSQKPAIRASTASSRGETTQEILEYYQYHSDRDSHPYTVRLGRFFYHGSVHYLPNGVSVGAESIGEIPQSFTKARSYFLRVARTLWPLDFEPGTDHPAGRRKLTKEQEDKIREPAMVSAFFLGRMSLRGEGQKQDYKRAKMWYERASELGDREAMNGLGIIYRDGLGVPVDVSKAQEYFQAAASAALSEAQVNLAKLVLAHGDLKNSYPLLEAALRSGNPLEAFHLSARVHTNARSLSQPGVCGVAVAYEKIVSERGAWYEDYLQEADHAWARGETSKAMVGYYIAAEMGYEAAQNNVAFLREGGWRFEAEEEEQWSIGSSRGEDKEKDRLVWWIRSAGQDNVDAMVKIGDHYYTEGQYPRALSHYLSASETQQSPMAYWNLGWMHQAGLGVTRDWHLAKRYYDLSRDTGEEAMYAAGLSLAGLYIQSWWTHFKTRGATPGLALFDYDAVPASESLSTWARIKTLFTSPFEWADLEYAEDWEDNLEPDGIVLGEGDLQDDRGTGGDDWEAEMFADLAEDMVLVGLLAAIAGLVWVRGRWAAANQRARARALEAAVQGQGQALPVPTGGELAQAQAQPPQRLEGDEEAGDQQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFA4</accession>
    <name>A0A1E3JFA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032637.1">
        <property type="nucleotide sequence ID" value="XM_019175534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFA4"/>
    <dbReference type="GeneID" id="30192617"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="57117" checksum="30451BA664CCA101" modified="2017-01-18" version="1">MSDIEKGIESAEDGKRSRSSGSEAFEGLPAVDPGVYSGRHEVGEPTGRWAKFDRFNRSLEQKMGIESRGIERVSESDRTDKRLYGNTFIWMSANMVLPTFGIGILGPLLFDLGLGDSMLAILFFNAGTACIPSFMATFGPKLGLRQMTSARYSWGFYGAKLVAFLNCIACVGWSIINTISGAQTLVAVSEYRISDAVGTVIIAIVTLVIGLFGYKFVHTYERYSWAPTFVTFLVMVGIAAKHLVNVPMGVGQAEAAGILSFGGTIFGFTIGWSSLSSDFNVYMPSEAKSRAVFGWTYLGLIVPLLLVEWLGAAIGAAATVYTPWADAYAEHELGGLVGAVFIPPMGNGGKFFMTLLVLSVVANNTVNVYSMGLSVSVVANWLAAIPRLVWPFVITGIYIPISIVGANHFADSLEDFLNVLGYWLAIYATVVIEEHIIFRKRNYDNYHASESWNRSDKLPIGLAAIFAGCCGVAGAVLGMAQVWYIGPIGAKVGGTADPFGGDVGWILAAVFTGVVYPGARFLELKWTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFG3</accession>
    <name>A0A1E3JFG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal recognition particle receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032644.1">
        <property type="nucleotide sequence ID" value="XM_019175541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFG3"/>
    <dbReference type="GeneID" id="30192624"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="651" mass="69815" checksum="7DDBFC31CB4B9BCF" modified="2017-01-18" version="1">MLDHISISHQSGLVLWSRSFTPAFSALASSPNSPVNALVKSTFIEGKAVSNGEEEGLEKDGFSVRWTVENGLGLVFVVVFPALLPLAYIPQLLERTKALFLALFQPYIATLVESLTAGGTTISAAGSALKELKDKISEERWNDIWDRCLKSCEGATSTTSTPGTTSPETSDLDSSATPLSAEEIAKNAQAMRSKMKGGGKRRGLRDGLSPSPSPSPSRPNKSAQAKLMRKWGDSPASKAEMEALDYSSPAPEEIKVDTAALVSVDALGEKKDNGTYEVADWDFKRPALSGGDLPSEEDILARRTTKLALSDEDVQQSTWSNVFSRLTGSKTLSKDDLAPVLVEMEKHLMGKNVAKNIAENLCESVGAALVGKKLGGLSSVKSQVQAALNTSLTRVLTPKSSTDLLLDIQRKRSSHLSTLSTSDGPDPYTLTFVGVNGVGKSTNLSKVCFWLLQNDLRVLIAACDTFRSGAVEQLRVHVRNLGALGEEMGKGKGKRIELYERGYGKDAAGIAKDAIAYAKQNHFDVVLVDTAGRMQDNEPLMRALAKLVTVNNPDKIVFVGEALVGNEAVDQLSKFDRSLKDFSGAGSGSGGRKRGIDGIILTKFDTIDDKVGAALSMTYITGQPILFVGCGQTYTDLRQLKVNHIVQALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JG09</accession>
    <name>A0A1E3JG09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_03419</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032652.1">
        <property type="nucleotide sequence ID" value="XM_019175549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JG09"/>
    <dbReference type="GeneID" id="30192632"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130321" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="268"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN99575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="39944" checksum="3D69BE97360531F1" modified="2017-01-18" version="1">MLSSLALALLAAAPLVAAHGQVSWVSVGGQQYPAWTLDDYYTALYREQDPVYGQIPETKYTRKTEKLDLGWADITSNNIATGGYDVCSRFDDISPVGTINANAGDEVVVQWDQWPTTGHPGPIGEMMAKCPNDNCSKVDATTLDWFSIAQHNYNAHTKQWPTDVLGANGLQWTFKLPTNLPSGAYLLRHELIALHEEYKPQHYPIAMEIKLSSSGSNLPSLTCKFPGCFGSSDWEEQHNIWDDDLTLWQFPGIGVYSGGYTTGVVNGASASSGSSSGSNSSGSSSSAGSSSAESSQASTASASPTSTQSSGGASVGVSLGAGSTSLGAQAATSTSGKTCKKNRKRNTVAKRSAGMPKRHLHRQAAYLQAKRAQAHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JG43</accession>
    <name>A0A1E3JG43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial outer membrane 72K protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03459</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032692.1">
        <property type="nucleotide sequence ID" value="XM_019175589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JG43"/>
    <dbReference type="GeneID" id="30192672"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN99615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="622" mass="68894" checksum="FDC3B6E0A9FC66A5" modified="2017-01-18" version="1">MSPLPTPPPPSIPAPSAPLPASTLAPPPSLLSRTQKFVEENQRLILLGCAVLAATGAGYYFYSRPDAPGPSSPAGGESASKKKNKKKKKSSEKKDEKFVRNDGDKGPLLEEREPAQEPGHLSGIPSDSEIEHMSGAKRDELGATLKDRGNKLYAKKDYKKAIECYTKAIEISVKKVAVFYSNRAACYGNLTPPEYEKCVLDCTEAVKLDRTYTKALKRRATAYENLDRNEEAVQDFTAVSIIERFADEQAAASVERCLKKLATKRAAEILANRGDRLPSPTFIGAYLSAFRERARPAIPESASQGDHTLSLAFDALDAADYPHALTYVNEAIEQGISTKEVQAEAYNLRGTFKFLIGDSEGARVDLQKSLDLMPDFVQSWVKIASVHMELGDPAGAFGDFEAAIRHNPNDPDIYYHRGQVYFITQEFDKALSDYTKSVELDDTFIFSHIQSAVAQYKMGNVGASMAAFRRILKQFPDRGDPSNYYGEILLDQQKFEESLARFDKSIDLDKSKSPRNVLPFVNKALALFQWKQDAAGAEELCKKALEVDPECDVAVATLAQLSLQQGKITDAITWFEKSAQLARTEGELINTITYEHASKAQIHFLKNYPEYAERLNQIAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIC4</accession>
    <name>A0A1E3JIC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032765.1">
        <property type="nucleotide sequence ID" value="XM_019175033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIC4"/>
    <dbReference type="GeneID" id="30192105"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000050">
        <property type="entry name" value="Related to XPT1-xanthine phosphoribosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24542" checksum="FD0A57E0FC83D2F2" modified="2017-01-18" version="1">MSDIKTDVEMLRLSYNDIHTAIQKAAVQIQAEFAPNLFIAIGGGGFIPARMLRTHCKKDVDGKKRNIPIQAVGLVLYEDMGGVEEKVGTEVVRTQWLDFSTLGQNFTQGGLLGRHILIVDEVDDTRTTLMYTVKELQIDINKQLELVENVQERERLRAQTKLGIFVVHNKLKPKAGQLPEGVVYFSAVDTPDVWLAYPWECDGDIYAHDALRVHNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLZ0</accession>
    <name>A0A1E3JLZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-independent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033085.1">
        <property type="nucleotide sequence ID" value="XM_019174706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLZ0"/>
    <dbReference type="GeneID" id="30191773"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="66791" checksum="7E36721788672DB9" modified="2017-01-18" version="1">MPSPPMSSPPSPPYNLDPPFRGYIESTLDALLVFEAARRGMIPRVTRRLIERERGMVQSGAVFVFDEHESGIKRWTDGLVWSPSRIMGNFLVYRETDKRSSSKASNSPTQTSPPSNSNTLARPTSSSATPHKFEAQAVLPHINTSIAEANGEPSPLGQGALARPKSSSEGSGNMDRQKERQLVGSLTNSYKFKKGGLVKKTMSVSVNGFAQHVVSYYAIDDVINGKLRSPSSIPELASLEISAEYLQKQNFRFPPQVEVGQDGIPRYRGEPEEPTSPHTPATNYSFQAYQQQPPPAGADYYDPVNAYLHQHQQLHRMSSPRSRPVNVPMLVPLPSPAHSMQGSSYMGPSSAGSGTFYSESPVNGMGYAPPLVRQNSGSSVTSTGSAIRPGSGASRRYTPYGPGNRNSNGSSVGYQVHARRTSDGSQNSPYSPDASYDIKPTPSPYYHTPDTAPSTFSSFYPPPEGHHMEQMASPTYPGYAPWQIHPSQQGGQGQTSRLIPTRQEYAAPPPLGPPPPGHGRHLNPPSSSGSGDSGSSDAPPALPPLHHHPHHAPPHYHPHGSSGGGQELQREWSHQSQGNVPHAPGWEGMGVGAGTPSPEYGVPIHQQHEEWRQGAGTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM09</accession>
    <name>A0A1E3JM09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033150.1">
        <property type="nucleotide sequence ID" value="XM_019174771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM09"/>
    <dbReference type="GeneID" id="30191840"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO01898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58711" checksum="55E960145D9780F6" modified="2017-01-18" version="1">MASLDAEKASIEHIESGDGKDQKISHRDMKHGDKALQFLGDERVEVTEEDDKRIRKLTDKYILSVLAWVYLLQILDKTLLGYANTFGLSVDANLGGNQYSMVGSISAIMQLCWQPFSSWLLVKVPPRYLMPTMVFGWGAAQACMAAARNYSSLMACRALLGLFEAGCLPLFSLMTSQWYRRSEQPLRVAIWYSTNGIATILASILAFGLSHIDNPHIKGYEVLFLLCGLVTVLTAPVIYLLIDNDISTARFLSDEDKAKGIERLRANQTGTGSTEYKWAHVFEIFYDPKSLLFFAITFFVNTGASTVNVFGPTLISGFGFDANITSLLNMPLGALQFLTIIGGCFCASKFKLKSAVLAAFVIPVIIGLALLYVENTRKGGNGLRQGPALVGYYLLAFLFGTNPITVSWIVANTGGQTKKALLMSIYNGASCLGNVIGPLLFNAKDRPHYLPGIRANLGLFCALFGTVGLCAFYLFDLNKQRQRQRVAVGKPKYIKDTSMSSKYETYGADDATLGQNALLDLTDFKNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM24</accession>
    <name>A0A1E3JM24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033173.1">
        <property type="nucleotide sequence ID" value="XM_019174794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM24"/>
    <dbReference type="GeneID" id="30191864"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="305" mass="32818" checksum="EC6B41EE2B4E6526" modified="2017-01-18" version="1">MSVPRLLVVGGNGFLAGSAICKAAVGKGWEVSSMSSSGKPFTTPAGHTPAWVPRVTWHAADAFSPSSYSSLVSSSTAVVHTLGILLEDQGYKKAVREGDILGLAGSMVKALEGGANPLKSAEEKKRGYEGANRDSALTVLNTMISTPPHPSPANEIPSERPFVYISAADAFRPAVPKRYIETKRQAELEISRRCSETEGIKPVFIRPGLMYHPHTRPLTTLPAFLIDLSAKFHAFSRLPNLFSSGSFLHGASESLRTYPLHVDHVASAVLRGIEDEKLRGVVEVPEMRGWAGFGEGKKGEVEWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JNX1</accession>
    <name>A0A1E3JNX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033079.1">
        <property type="nucleotide sequence ID" value="XM_019174700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JNX1"/>
    <dbReference type="GeneID" id="30191767"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47219" checksum="B9486A376A957123" modified="2017-01-18" version="1">MCESFSLFHPEPASSYISTADSISALLNTLNPTLVVVDHMFDAARDAVLKGRWRSVRLSPNTVKDVAIDCQGWGIFKWPCFASGYPFPLPWYLFLPNTIGLILPIICLNFSRTFASFNIARNKAGYPGVIPLYSSGGPFPTKVLCMSTPEADLPAIIPEKIICCGPILQAVSPLPDQDPELDLWLAQRPTILISLGSHLKLSHSYATNLLRAISHLLSARSDVQVLWKLVPDGSYDYEAFSEEEGELGREKEKWGERLKVLRWLKAEPFAIMNTGRVICFVNHGGSNSYHEALATGVPQILLPAWLDCYDFASRVGYLRNGVWGNKNSAPSCSTPELIRAFDEIIGLSPPTSSSSPPLLYRQRALELQAIVTRNGTRRGRDVAAEVVWEEMEEGMMWGNKYEEDEGGMDEGGDSVMVDGEDEKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR36</accession>
    <name>A0A1E3JR36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033366.1">
        <property type="nucleotide sequence ID" value="XM_019174314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR36"/>
    <dbReference type="GeneID" id="30191373"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO03315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="491" mass="55051" checksum="0E9182532BA46361" modified="2017-01-18" version="1">MATRSIALGPQETAFVQLLDAFATAQNPPVECRIAGGWVRDKILALPSADLDIALSISSGYAFAASFVDFLHTKGVSTGSVGKVVANPEQSKHLETGCTRIMGLECDFVGLRSEKYTDSRIPQVEPGTPYEDASRRDLTINALFYNVHTRQIEDWTEKGLVDLENQIARTPLAPRQTFQDDPLRIVRCVRFASRFNLHIAEDAFECIKEDDVKLGIIDKVSKERIGIELTKMIHKNPYRALELIHQLGLHPYVFHCDVNPPRHEAFAAAQILNALSDRKQLDEMLWLATAATPFRHLDVKRKGKSVPATAIVIGEGLKLSTEIKSSVSNLFDAVKVIDPGATRRSDIGAVLQLPSVRPWRRSLIWAVVMEVLPQWRGGWDEAAEAVYQKYEDFEARIESLGLPAAIDKPLLLNGNDVQSLLSISPGPLITVIRQSLNLWQLDYPEATRDQAEEWLKSQWEGQQRVEWEKLAPPRVISKKTKKAEPGEKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR79</accession>
    <name>A0A1E3JR79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033439.1">
        <property type="nucleotide sequence ID" value="XM_019174387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR79"/>
    <dbReference type="GeneID" id="30191448"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO03388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="807" mass="86562" checksum="855CF503DC3D685B" modified="2017-01-18" version="1">MSIALGVYEIRGLADDAVSIYHPASPSLDLEGGNTLASGSLLNPHISTDQQYPYANLLASEPPNHAPSQYGSSLGGTPTYQSYHQDKDYINNSLVGASHSLASQNTAGRAQTARQHHRVHPYQTSTADVLSRHTSAKAHWDDVSSPDQDISTHFRSANSSAANTPAAGPSTTTTAVNTPNSMAKPSGRSGQKRRQKYTRTRTGCLCCRSRRIKCDETRPICKRCVIAKKECVYPEGVHGSGNISSSREDKKGKGRSSGEDSESEADMSRSRPGTRPGSPSGAFFPPQTALAYPYGGSSRAGGSNAFDGSALNVAPISGGLVGSSMGGGMGLMEMGLNMNLGMGQQSPSDGSALNVGREGFAADASKQAWGADQGGAPMLATPDFLLPWFPTAEERSLILHYCANAASLMMAIPSGLNPLLAINLPLALDSPRGMNPSADALRVALLGIGAIHQAFLLARSGVSNSQTAAMFQYASTLRETGKEMVRRAARTGATDAALGASTALATIDIFFGGANWQDNFTLAKEMVSTRGGPSQMLKDSTPTALSEGVTVSPARLMLEILAIYETFGCLTSGDEPTMIPEHGQNWWLEANRSMYEEHSVEKQFGMSRVMVLLLNRLTRLINRVAKAGTIITEQAPSTNAGSNSFVPTPSSTPDEVLIKEARQLNKDVDIWIESLQMSTLEHERVQVGNRAYAHAMKILLLRRIFKYPQEDARVQRAAQQVLQHCSWSTAALGMSIDLTWPAIIGGCCVDGSSRQWVTTLLEGFKSQCCFDIDSAARIISEVWRRVDAGERRADWKEVCDDLGLHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRD5</accession>
    <name>A0A1E3JRD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033492.1">
        <property type="nucleotide sequence ID" value="XM_019174440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRD5"/>
    <dbReference type="GeneID" id="30191501"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="46958" checksum="44FFBA7BD3BA5F77" modified="2017-01-18" version="1">MSTIPSLPVPGEQQFPRRLLHYIAAHPALRSWALSPPLLSILLLVLIVRQGGLVVDVEDDGRDKLVSIVYAMMESIFSMTVRTLSLSAVTRTDELPWSLFRNHTPRHVPSQESQLSDVRPRIGSRKSTNLEVNGHLHHNLDKDHLDLPEVLIVTGLENASGPVQMKMCDYLTKKRVEARVENEDRVWEFEPVVVWVRREGAEVPWWVTDHFMCGTTVDPFAMDKPPRGLRPGAIIPQPYLKTLSLLLPYTHIHASISMHISNLLSAITTHPSLHSAITSRAVRAFPIYVRAHRLLVGDFTLPHLFEVKLHQQDSEGVGSQNKKGLGGGTGGVDSWNIIAGEEPDVNGLRQEGNEEDFDGWHVMPANVQGVWNVLMAHRVKKRREREEVMWLVKGPAHGGRRSAPGGSIDDILNEIIRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS50</accession>
    <name>A0A1E3JS50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease regulatory subunit 10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033704.1">
        <property type="nucleotide sequence ID" value="XM_019174652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS50"/>
    <dbReference type="GeneID" id="30191717"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000168">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="402" mass="44660" checksum="CF5D77FB838A74C0" modified="2017-01-18" version="1">MSAAASSSTRPPVVRPADMPEDKYTAINAYRQKVKEHSRMSDNLKTVRMNIRTLGKDFDRTEDDIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVSYRPTLPAAKLKPTTRVALDMTTLTIMRILPREVDPMVYNMSLEDPGSATFAGIGGLGEQVRELREVIELPLMNPELFERVGINPPKGVLLYGPPGTGKTLLARAVAATLNTNFLKVVSSAIVDKYIGESARLIREMFAYAKEHEPCVIFMDEIDAIGGRRFSQGTSADREIQRTLMELLNQMDGFDSLGRTKVIMATNRPDTLDPALMRPGRLDRKIEIPLPNEQGRLEILKIHAKGVNKGGDIDYEAVVKLSDGFNGADLRNVCTEAGMFAIRDDRDAVVQEDFMKAVRKLNEAKKHETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTS8</accession>
    <name>A0A1E3JTS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_02177</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033383.1">
        <property type="nucleotide sequence ID" value="XM_019174331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTS8"/>
    <dbReference type="GeneID" id="30191390"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="211"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO03332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="412" mass="45830" checksum="FA7CD90602DA5691" modified="2017-01-18" version="1">MEGSPSANDDGFSTFFSETGSGKHVPRSLYVDLEPNVVDEVRTGAYRSLFHPETMITGKEDAANNYARGHYTVGKDLVDSVLEQVRRLADNCSGLQGFFVFHSFGGGTGSGFGALLMERLSMDYGKKSKLEFSVYPAPKMSTSVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICRRNLGITSPSFTNLNRLIAQVVSSVTASLRFDGDLNVDLNEFQTNLVPYPRIHFPLATYAPVISADKAFHESNSVYEMTTACFESNNQMVKCDPRQGKYMACCMLYRGDVVPKDVQAAVANIRTKRTIQFVDWCPTGFKIGICNEPPALVPGGDLAKVSRSLCMLSNTTSIATAWARLDNKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDSEMDNFEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU98</accession>
    <name>A0A1E3JU98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033553.1">
        <property type="nucleotide sequence ID" value="XM_019174501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU98"/>
    <dbReference type="GeneID" id="30191562"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="516"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="844" mass="94480" checksum="6DEF8088DA777822" modified="2017-01-18" version="1">MSSPVATWDTIQDVFYRKDTVYDMSWSIPDLSDYIVATAKNGGPVAMIRDERKIMLLGRHAAGKPKIYVYTSSGILLSTLTWDLTPPVLLHFTSQNLIVLSDEGLYRVYDLSNPTEYKQYTLGSEVSSVGIIEAQAWEDGLVVLTGDLQFLEVRRWGGGRAVPLCPSELKELPASWTLLSPDKSPSGHVQVLFSINDTIITLDALERIDQHVSRGPFSQIRISPNGRFLALPTVFNTLWVVSSDLSRNLSEVDVSQWGDGQPDRVEWCGDNAVVIAWGGKVAVAGPGGDCLIYDYSPSAHLVGEIDGLRVISSHVCDFIQKVPDYSLAVFKPGSTHPAAILLDALDHFERKSPKADESVRYIRAELADAVDTCIEAAGREIDSYWQKRLLRAAQFGRAFIDLYNPSDFVEMAQTLKVLNAVRYYQVGIPITYEQYTSASPTFLISHLVSRNLHLLALRISQHLHLRPDAVLKHWAIAKITHASSQSIDPSDRGIADDHTICSAIVAKFQKEGKRSVSYAEIAKKAWEAGRTRLATMLLDHEPRAAEQVPLLLEMKQDKLALGKAVDSGDTDLVYQVLLNLHSSLTPGDFFHLLDDSLSPNLSPAVNLLQVYARQADRQLLRNFYYQDDRRTENGCLDMEEAGESASVEKRKERLGEAARHFGESKERAFESKMAEDAQRLLTLQDSYQNELSTPTHQYYFASLSVNAFIHALLIGGFSKRAEKVRSDYRVPDKRFWWVKLKALAEVKDWDALEVFAKAKKSPIGYEPFVRHLLKVGEPQKAASYVARCDAKARVDLYVECGEWGRAAELAREKGDKGRLEQLKRQAPTGLAQRDVEEVMRRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUN2</accession>
    <name>A0A1E3JUN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033693.1">
        <property type="nucleotide sequence ID" value="XM_019174641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUN2"/>
    <dbReference type="GeneID" id="30191706"/>
    <dbReference type="OrthoDB" id="2589163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="516" mass="54288" checksum="2A3A79C1935EA782" modified="2017-01-18" version="1">MYHPFPTPPTPGTARDHYSFPPAHIPHLHHPVHPIHHPPPPPVRQSSSNSQSASSSRRGSHAQGQYSDSESDGEDDKVERDKLEIRREKNRVKQRNLRLRRANHIADLERDVSTLKSESSSLSNALSLAHAREASLQGWIHDLESVLFRNGLAADVEGMRRVWAERGAGSAGAVPGVGPGAGSRRGSLYPPAVGTGVNGDPLSTLARAASQQTPTYPHPHRHPHPHSHSQHSQHSHHAHHPHGGHPTMQMPDRPTLPRPGSFSKPYDNPYPTPDVVWPPSREPDMSLGAGSSLSAGSANAPAPGEGGKRKRGNDWEPYGLAGPGAMPPSASSSASAQNPNQPRSASFSHHSSQGQPGQQAMAGSGMSRRSDPSLNTLPPIHALPDANAPGGSPTSTGSAAAAAGSFFPPGASASHSTGAPSDERGTQGQGEGKVSPRLIRISDLVSPSHAGETFWGHGEIKRESIGLSPKQIPTDPLRLPPFRLQGSTSSTASTASSAPGGHGGHELPTPLSEMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW90</accession>
    <name>A0A1E3JW90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01802</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033770.1">
        <property type="nucleotide sequence ID" value="XM_019173963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW90"/>
    <dbReference type="GeneID" id="30191015"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING_fam"/>
    </dbReference>
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        <property type="entry name" value="ING_N_histone-binding"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
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        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="285"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="201"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="331"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="310"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO05115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="348" mass="38085" checksum="2C93F19320C63495" modified="2017-01-18" version="1">MALPPSLHVHPHFNAEEAAHVVTGLISSLENLPGEVNFLLEEIREKDIRITQLIQRINSRHISLTKPIKSLSSLPPSTATFPLPIPPGAPLPTSHLTQKEAQNLTKIQTEWQQISALQDEKIHLAERLERIVNRAKERAKDHWVKVGGMSVEEVEKAANGLGEMGGVEVVLPPGGLGSGSDARAVKKRKVVAAPVPVPKVQHPALAMPPPPAPRPSLSARSSHSHAPSPVGHVSHHGPMDHSHGHGHRSSRKLSIMSDEDADGEPDDADVDMNDAGDGEGETDETLYCICQQKSYGEMIGCDNDKCVYEWFHVKCVDINGPLPETWYCPDCVSRYGFSNDKNKKSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWA2</accession>
    <name>A0A1E3JWA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019173973.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="127"/>
        </location>
    </feature>
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            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
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            <end position="209"/>
        </location>
    </feature>
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        <location>
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            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
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            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="466" mass="50066" checksum="C0721A7D6820E67E" modified="2017-01-18" version="1">MAAEAASSPAPPADTTNTPQKPKKQRKRARPSTASVAPSAPGTPVAASPVVVEAPKPETPVNTPGEGERKPRKPRARKSKGGVETALKASSPVAAPDVVVPAEVEVKADEAKSEEVSKKKKKEKKDKKKQEQPAPATEVASAESSEPAESAVATKQADEEPKKEAKKSKKDKKAEKKAAAQVVTGVEEVAGKVVEEAPTVEATEASETPTTDKKDKKEKKAEKKRKREAEETPAEPTEPSTSETALPAEPKKPKRSKIKSLKAGEKSDAEKAEAAAEAEGGDGKEKNAGEKIFLDERLSDQGKKNIFYAHLFTLSQTSASSPPAETPSTQWKFSKAKQNWLIRNVFNLSEVPESYLPTVLEYLKTIQGLSRTNLIDTAQKIITPPAPTTTEGAPTADGDVEMSESTTEPIAVDGDANESKKDEEKKADEEPKVEEVDPAKAEKQKKTEEEREAKKERAEKLMSAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWC4</accession>
    <name>A0A1E3JWC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033813.1">
        <property type="nucleotide sequence ID" value="XM_019174006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWC4"/>
    <dbReference type="GeneID" id="30191059"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130587" evidence="1">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="408" mass="43457" checksum="88E11BF62E97439D" modified="2017-01-18" version="1">MRGTCSSLLLSSILLPLAVSSLPTHSFGPRANADLPGTFVEFEELAQCPVLSKRDTPTSAKDVRPDDIRVVMALGDSITAGLLARPASSLLFPTNTTFFQTVDVEEYRGISYPMGTDEGAITIPNILSHFVTDNATVQGGAKGHHAPAASALIAQDGLNAAVSGATSSLLTSQVTTYIVPKLAALGLPGDDDWVYANVAIGANDICDFCVAPNVGIAGVGTLGSPTAFANDIRTAVNLLRKHTPKLIVNIIGILPVSAIYNLTLTNPYCQPAILSDVPHLPLECACALTPGPIGDVTRQRMDSTGEAYDNAVLEIVKEWEAEEGDGFGVMWQPGSLIDLENYPIEALSPVDCFHPSEAMHRRVAAGVWNRLTLSLEEKYTKILWDDGPQVRCLEGDDRFQVNSLSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWC5</accession>
    <name>A0A1E3JWC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033809.1">
        <property type="nucleotide sequence ID" value="XM_019174002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWC5"/>
    <dbReference type="GeneID" id="30191055"/>
    <dbReference type="OrthoDB" id="10494110at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="31232" checksum="91B7BE6002109BD0" modified="2017-01-18" version="1">MEYMELHCPEDPPPLAAPVPTNAAPSGAPQFPQYHQQQVPASSKPSTRFYALPPESQPLLNKRKSDVALAFGSYSSESSKAIKANRPLTVEEYFARAFAVREGNLLGLLGLLPSLANHMVTEAHALSASAHRSSQNQLIEATHKRTARNRKTMGVPTQQMAVEISAISEPQTPSKTPEWTTIQDRSVSLSRTASSSVASQDGLGVSTTSGASGVLAPAREQSLVVQRSTRAYSPSNPVPAKHAAPPSTSSASTRTAIADKAPSMSMAARIKEINRLGDELMQQYERMMKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWP7</accession>
    <name>A0A1E3JWP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033943.1">
        <property type="nucleotide sequence ID" value="XM_019174136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWP7"/>
    <dbReference type="GeneID" id="30191193"/>
    <dbReference type="OrthoDB" id="2576148at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="806"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="836" mass="89311" checksum="799F3DBCB0B61C5A" modified="2017-01-18" version="1">MPPPLHLPIIPNTPSIADHLAALSALSLNLSHLPSSPSPAVRVPLGAKASLTGTVSDTNTVLVCLGSAGSGGRWGEGEQYWVKMTPDEAAAFVDRRRERILKEQARRIDGLGRGEEEEAVVDKGEDVVSLWHPSFYPVGAEPWTVSSGAPAGTTEQPGHLVEPPLLPQSGTSVIRDDTVSTQTVDNVPDIQPSPKPAPQQSKGSGKAPAQEPKANDLIEIMTEGAAAASKDAKEAKDDETIYNEEGLPFHEIRETMDGKTIGDLPPPSSSSTQETVLDDAPDEYWTEAAVKRREALRKKLFHEGDSSDEEEVDGAEPAPLGPENDVTPKSPSDHTPPQSILRKTSSSSSTASSRSQTPSSKPKSILKAPAQKKKSVKFDPSIPPSPSSPDPGPSSFQSQLLHGNKFSFPLPLAADGDDWGEKPVPVLNEPKPKAKATVLPIQAVGAQVVEKDDGFAGFKKGFLERPPKVQSATSPATTPSSQPKSTPVPEPLKPKKTSLFAKRLAHSEVDASAPPTSSGATPATASPRGLPNLPRESESKGTSAVKSGVVEKAPVAPAARSQGKVVERTTMPSKPLPSMPPIISLAPEQDDDHGDENDDDDDEDFSEFSSGSEDEYDLDDALLAREVALEYHKRRAYMSLNRDPRDRAMSSRPEGSEFVPEEGDIGEEEEDGRLGNLQQAGVMLGLPRIGDMKADDGKPMIINPTADDLKRFVRVGRLENGNLVLAPGQEGLSDSEGEGEDGEDGAEDEDLDEKEERRKGVKSRRDEVRRKLLGIDVEESAPADEKKPGLSERKGLPPALQTDVKEQSQPVAPVAAVEEPKKKISKFKAARMAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL9</accession>
    <name>A0A1E3JZL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034361.1">
        <property type="nucleotide sequence ID" value="XM_019173656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL9"/>
    <dbReference type="GeneID" id="30190706"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="219" mass="24854" checksum="57CE765C7BDD1353" modified="2017-01-18" version="1">MSTRDTTIRPPVTHLAYLRSYSSPSHFHSTTSYNAFARPRIKLHPRRTTQPHILARDAPPAPETHALSPVNSSTSSTSSNASSTRGLLSTERRHRRDDAEPNWQEVMEEEGEEFSGRGPWRRRAHEWNPWIAGCLQILLNVTMVALFSTPPDSRKWFLFANAVGSVVAFVFGIITLEFRRIWKTKEVRPVDFFLFFAAVCNVVAISFMFVAVFRGYVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K022</accession>
    <name>A0A1E3K022_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034506.1">
        <property type="nucleotide sequence ID" value="XM_019173801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K022"/>
    <dbReference type="GeneID" id="30190851"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="530" mass="57545" checksum="FEA9C347002F808A" modified="2017-01-18" version="1">MAPPRPQTTSDPNPYASLISQNISLVPEFTLESGATLTDIPVAYKTWGKLNERADNCLVICHALTGSADVEDWWGPLLGVDKAFDPTRFFIFCANTIGSPYGTISSVTTNPETSRPYGPEMPGSAVKDDVRLHYILLKSLGVKSVAAVVGGSMGGMTVLEWPLNSPPGFVKAIIPLATSARHSAWCISWGEAQRQSIYSDPDYKDGYYYEVEDEDKKVQVDLMKQPARGLAAARMAALLTYRSRDSFESRFGRRAGGGKSQVPRGGVRIMGGPETTDPSVPSASDLTKSPREKAWREHNDGHKGAGQRSASRRGSDLSEKGTAGNAEVVKTEEIKAEGKNVGTGEEPPKVFSAQSYLRYQGDKFTGRFDANCYIHITRKLDTHDLSAPSNDSSLNSLSSSLPAHSLSSDDENVNESELNSRLMHALSLEPPALVIGIESDGLFTTSEQRELAAGIPDAELVVIPSPDGHDGFLLEFEAINGWAGGWLRRKMPEFYGERVISLEEYGAGEAGFEVKKESVFGEAEADVTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K083</accession>
    <name>A0A1E3K083_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034610.1">
        <property type="nucleotide sequence ID" value="XM_019173905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K083"/>
    <dbReference type="GeneID" id="30190956"/>
    <dbReference type="OrthoDB" id="1681765at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF251">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="178" mass="19587" checksum="CAA01CD17AD60A82" modified="2017-01-18" version="1">MGLWTLRMGDSIRHCAEVFGQKRLDTVTGSLRTLVLALLSDDIIDEWIKIPSADEPDHPQIKDYSPHVFAGCRGALDGTHIGVKVPKRVRDVYVSGRKDEPTINVFAACNFDFDFIAIYAGVEGSVHDSRVLEMARATGNFAMPPGQYLLGDAGYGLSTDVLTPHRSVKYHTWEPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2A1</accession>
    <name>A0A1E3K2A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034747.1">
        <property type="nucleotide sequence ID" value="XM_019173021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2A1"/>
    <dbReference type="GeneID" id="30190062"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="31350" checksum="8D3F25D3DE779CBD" modified="2017-01-18" version="1">MTRTGFDFAHHARNNFLGQRLQGVPKATSTGTTIVGVIYGGGDSGDEPGVCLGADTRATGGPIVADKNCEKIHYLAPHIRCCGAGTAADTEFVTNLISSNLELHALSQGRQARIVTAMTMLKQYLFRYQGHVGAHLVLGGVDATGPQLFTVHAHGSTDKLPYVTMGSGSLAAMAVFESSFKENMTKQEAIDLVARAIESGIWNDLGSGSNVDVAVITKAGTEMLRNYQTPNERGTKSRNYIFRRGTTAWTKESIRSLIVKEEIKSTSGAGKEQPGVEVQGVATAAGAGGGDGMEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2J4</accession>
    <name>A0A1E3K2J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034542.1">
        <property type="nucleotide sequence ID" value="XM_019173837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2J4"/>
    <dbReference type="GeneID" id="30190887"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="649" mass="70638" checksum="BEB7D8966F8DDBB9" modified="2017-01-18" version="1">MSRQMGDQADFAAPVPAAPPVHTPATTLRAPALAHQTPDVSKSILRRSFSTPALKYPHLSYPPSSVLSAASYNSEMTEGITRYSPDNTPRSSASRPQGSGAAHARQHPPTFDSPTPHNVHYNSSVRMDGISGAGAIEMGELSGIQPPATFPLTEYPYGYTRQDPVPPEDGDELNNRYAYEANGSSRKKAGAPSCNPWDYLVGDHVPELLDNNLVARSGAARYGVEAKHGCKVRRRFTKRELEALEVLWSIAKSPSKYERQRLGAWLGVKTKHITVWFQNRRQEEKRYTRGDQQEHGNTSRANRGTFDPVTGKWRPVPASCISGLEPPPEDKISVVRAISVGEVTRETWLARYPSATGGGPTAAPQSSMTGSPSSASSKRGTKRPAQLLSARLSGQSLDEVLQARESGFGLGADKRYRRGSKGAAIEGEGQERNDRILSLMPSDPPSMGLTEMDPEESDGDDGGVDVEALERRKRARTLNGLGRATSFDLFASSSRAKQLAKPSKEQGHVLGQINPNLSIRPSASTAALKKPTLESIASSQAHRRPRSRGDDPHSYSRFKKEFSRAQSTSAIPQSSSRNESRRTYQPSQLKTPNLGYARSHSMSSSSSKVITPEDVREPRPVVKLEPRNEKDEEVIGAAEMLLSLFGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K364</accession>
    <name>A0A1E3K364_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034946.1">
        <property type="nucleotide sequence ID" value="XM_019173220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K364"/>
    <dbReference type="GeneID" id="30190261"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="79"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="36304" checksum="A6EC583C71FB9872" modified="2017-01-18" version="1">MLLKRLHTKLPPNLAPFIPELESAGIKTTESLIFTAPSTILALTSTITHVQLQQLVSVCIRLTSGGIMAANEMEYGDVEGPWRGFGVKGLDEMVESWDGVGVLEIAGPRRIGKSLLALHAVLRTLADIPEASCVWLDTEGTFAPERAVKILELWKVSDPHHILQRISVTPCFQLDNVHGALESLRIVVLDTIFTHFKDRLTNTSAQGHAELVSLMEDLSALSFAHNLVVLVINSTVTSFPTNPLSGFNKTNIKPALGTAFTYCTDATLLVQETGKVFGMMDEEERERVRRAPGLRALVEVVRSRVSPTGRWAVFDTVRIIYAFEVGADFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3A1</accession>
    <name>A0A1E3K3A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034900.1">
        <property type="nucleotide sequence ID" value="XM_019173174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3A1"/>
    <dbReference type="GeneID" id="30190215"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="532" mass="58707" checksum="A32E63BA8A1CB661" modified="2017-01-18" version="1">MTGGSSHVDWRSIPNAIDHTPWPKNRGLSKLFFFSSVLYMGQFLNGYDGTITGGLQALPDWNKDLGYPSAGRIGLLNAASYIVGVCMGPLNAWVVDKFGRKWPIRWYALAMIVGTVIGCVAGSQSGNTGYGLFVASRAIIGSGVPVFLMAAQIVNQEMAHPRFRPQMAAYWDCNWVLGSTVASFITFGTSYINSSWSWRIPYLIQLLPALYMLVAVQFMPETPRFLIANGKEEEAYRFFVDYHGNGDEEDELVKFEWREMKETIEMEKGEKLGWTQLLKTRANVHRLGLVALITTMPQLNGSTIISYYYSVILTQCGITGAGQITGIGAGLNMYSFILQCLGVYSLRYFGRRSMVLSTWPLLILGMAAMAATSGVYQHSGQSDKGAGIANVVMVWLYSTPWNYVSPIFYSYPAEILNYEIRGKGMAVWNTVNQGWGAYGSYVNSIALDSIGYRYYCVYIPILALQWVLTYFFMVEVKGLTLEEIATAFEGDNAAVARVDARLAEGVSGNIGEGDDDEKKLGLSGASVIAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3B2</accession>
    <name>A0A1E3K3B2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034998.1">
        <property type="nucleotide sequence ID" value="XM_019173272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3B2"/>
    <dbReference type="GeneID" id="30190313"/>
    <dbReference type="OrthoDB" id="10299849at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="334" mass="37357" checksum="EF3B643075784224" modified="2017-01-18" version="1">MSTITEVEQGLVERINPEEIPGIFQEITINADVVKTDKTQLSYHTQSFQPLLDEPETDGYDFMRGSIAGSRMFNDNRRVRLVLEDPMPPMSSVNGQFPVYEERNGTSVIDFELPTLGEDSEQDDYPYTLQSDIVLALPHEKYTIPTDVTCFYSQLTPSERAAREEAQQGSWIKAVETYYVSREKLEVLSDMPVLKPLLDDIDGLALEGLASGALVIADGHRSNDYGIEQENGRFQISDDITLTRVDEDGLRQVHTTRATYTPYQDSVTRPDASDDFHHVTCATSGPDTISRLTMLVPQRVSLDATLAEGARERRRRLEEDVAGGSCAADLRGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4T0</accession>
    <name>A0A1E3K4T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L198_00831</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034729.1">
        <property type="nucleotide sequence ID" value="XM_019173003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4T0"/>
    <dbReference type="GeneID" id="30190044"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="239"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="528"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="745"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1005"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="598"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODO07252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119331" checksum="2E39FB3364285386" modified="2017-01-18" version="1">MVREPSHAPLHQTDPRQASSDPRARNLLATIASEKRNLEGAKAVIRALEASSKNENVIRQAQNEVRSAQASIQYLEAELEKLSVSGPNTPNRGEGSRPGHLAPGGRSESHLPASPSPSAKGFGNSERPLPPPPPGAEADAARKPEQKNYTQLDLLRYDAPLSGAKITRMLNQLQFKLQVEEQYKTGIEKMAQAYKMEGDKRLKSETDAKKVESEGKIQLLRKAKKRYETLAKFGGGVEDDEDLVPDSQRKEALRKPISGNLVISLRAAQDLNHRPLPRRSSKAYTETTVVVKIEGNERAISAPSRNDKWLEEFNIPVEKANEVEITIYDSVAPGDSAPIGMLWLRVSDLVEAIRRQKVGIEGQDAGWVTAATAATMSGPRSSGTAPDSVTLHSAGTMRGKPDGKASEGISGWWSVEPAGGLQLRLDFVKDTVAGARRPYEALGRQGAVRMRKGEVHEMNGHQFVQRQFYQPIMCALCQEFLLTGEGYQCEDCRYACHKKCYPKVVTKCVSKSVADGEGDEEKINHRIPHRFTAYTNMSANWCCHCGYMLPFGRKNSVKCSECALTCHQTCSHLVPDFCGMTMEMANLLLKNLRDIKTTQTRRPHTHSPSATSVSTLPSYHSQDKVQTVQPAQPPVQQPSGYDNIRPAGPSGGRPMPQLPPVPVSDSSISMEHPSQDGYARMPPVAQQPQQQQQQAPPRPLPPTTQFLQAQPAPQQQAATRLPLQPPAQPTQPLATRKRKVGLDDFNFLAVLGKGNFGKVMLAEEKASSSLYAIKVLKKEFIIENDEVESTQSEKRVFLAAAQERHPFLLGLHSCFQTETRVYFVMEYISGGDLMLHIQKKQFTLRQAKYYACEVLLALQYFHSKGIIYRDLKLDNILLTLDGHVKVADYGLCKEEMWYGKTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGVLTYEMLLGQSPFRGEDEDEIFDAILEDEPLYPITMPRDAVSLLQRLLTRDPERRLGAGPGDAEDIKKHTFFRDVNFDDVYHKRTPPPYFPTIGNATDTSNFDSEFTREQPTLTPVHTQLSEADQKEFAGFSWVSAPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K538</accession>
    <name>A0A1E3K538_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034839.1">
        <property type="nucleotide sequence ID" value="XM_019173113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K538"/>
    <dbReference type="GeneID" id="30190154"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="11626" checksum="2703FCAC22600878" modified="2017-01-18" version="1">MSDSNQPKAPLNIPSGNSQITPEPQPLKPDERLTGDKLQDFKSAFGRIKPKNDLENLGKMPCARNSLLYGIAGGTGIGAVRFLGSRRPWSAANWAVGSFLAITLFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K565</accession>
    <name>A0A1E3K565_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035114.1">
        <property type="nucleotide sequence ID" value="XM_019173388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K565"/>
    <dbReference type="GeneID" id="30190431"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="278"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111206" checksum="50F3D99082A4A786" modified="2017-01-18" version="1">MNPGQVYTAGYPQGQPQQQQQYGDPFANPSPQRPPSAPLYNQQQPWAEPQGSHHHASYPLQPISPISPNHAPRYSVPTAQPLPYGVSPAASHAPIPAVSSPTRTRYHSNPSYLPPPQHTTPTIQHVQAPAYSYPSGIGDRLTSPPPLMPHHSSHSNVGLPADYPHNSYPPESYGNAPEDDMNDSHPLLAHAAPDPRFGIAASQSAMAMHPPPRPGTGVRYQLSDNGAGDMGVPMYATPGRAEGQAGFHAGDGLGHDNEDDYGNVHYGPIPSRIVRRNRTQKRVQLFRGHLVLDVDVPSMLLDQCPLRQGNEFTKMRYTAVTGDANEFADKYTLRQRLYDPPRQTELFIVITMYNEDDVLFCRTMRGVMQNIAHLCTRSKSKTWGENGWKKVVVCIVADGRLKINPRTRSVLAALGVYQEGVGKNMVNGKPVTAHLYEYTTQLSINSSGKIGPGGSGTVPIQMLFCMKEKNQKKINSHRWFFNAFGDCLRPNVCVLLDVGTQPGPDSIYHLWKAFDINSSVGGACGEIVALKGMFWKNLLNPLVAAQNFEYKMSNILDKPLESIFGYITVLPGAFSAYRYIALQNDEQGNGPLKQYFIGETMHGSGAGIFAANMYLAEDRILCWELVSKRECKWKLHYVKSAYAITDVPDTVPELVSQRRRWLNGSFFAAIHSIFHFGYLYRSSHTVTRKLFLHVELVYQTLSMIFAWFALGNFYIAFFVLTQSLNDLGSAWQYVNTPLHYIYVGLVLWCFLLSLGNRPAGSRIGYTLSMVGFALITVYMLFAAIYLAVRGIQSIEAEGDITASTIFGDRIFRNIVISLLATYGLYIISSLLALEPWHMLTSFLQYLLLAPSYVNVLNVYAFCNVHDVSWGTKGSDKVSDDLGAVKSSSDNKDEVDVDLPVEQKDINAVYAAELGVLSTKAPKEVTVVSEDQKQEDYYKNFRTNVLLAWTMSNGALTAGILQSSSGTSSLATTYMGVLLYTVAGLAFFRFLGSTIYLIVRLFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5L4</accession>
    <name>A0A1E3K5L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel, nucleotide-sensitive, 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034999.1">
        <property type="nucleotide sequence ID" value="XM_019173273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5L4"/>
    <dbReference type="GeneID" id="30190314"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="29819" checksum="58539057CEE6F910" modified="2017-01-18" version="1">MLTQTSTPPQSISPEQHAQLTSSTPASFTDIPPVLRWEDDAEVELSSLSGGWEAWGSQGTKAGGRLYVTEESVAFIPSASATPGFNLPYVYLTLHALTPASANGPAHLYCQVDESDAPGSDAIQVDAPVNGNGAVNGEAEDEDEDEEVEGEEEFTEMREVRIYLPDASKLESLFAALSQCSALHASLLPNGEPSNFFGFGADDSDGEGEDGQWDDADEEGQDETGRIDKRIKVATAEKVEDKKAGDEEGEVVDQMERFLNMVDWGNVEKPKGWDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Q3</accession>
    <name>A0A1E3K5Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035361.1">
        <property type="nucleotide sequence ID" value="XM_019172419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Q3"/>
    <dbReference type="GeneID" id="30189449"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="52768" checksum="7F66B83F30E3CF50" modified="2017-01-18" version="1">MAPPSPAPRNKLVIRRLPPTLPEDIFWNAVSTWITDKSCLCKSYVAGKAPNGNLDSHPVHSRAYVLMSDPEALVNFHRGFDGHVFRSKTGAEFQAVVEYAPYQKTVHKARVKPDNRQGTIDEDPDFLSFLKFLDTPAPESAQHTFVPAAPQPSTTPLLDHLRSQKSAKSKGKGKATPAPSQAPSQSATPVPTVSAPLKGKAAALASIKDASQRRHLLAQGTPSQVMVAGKGREVSIAPSTSTSPAPGSSAAGGGAKKDGKGKAKEKGDKGGEGAKETGEKGKKGRSRNRSKKDKKEKGDGAATPTDRQTPNLQPKSFPPLPQSTPKAPTPAPAPPAAAVPAAPAQTVPPSSNQRALAPRVAQPPRPPFAPQEPAFTARPPPQSPIRPPPMRGGHVRPMGQPARPHIPAMNQGMPLNHSVRPVSPRGAPPHMGLHANSPSMFNGGARPAPGPSGQGMGPSSMAPGGSGNGSRRGNRPPPKQAAQVTILARDAAAGAGSDTGASSARIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Z1</accession>
    <name>A0A1E3K5Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035292.1">
        <property type="nucleotide sequence ID" value="XM_019172350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Z1"/>
    <dbReference type="GeneID" id="30189380"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="356" mass="40158" checksum="314E2A4E3BCFAAB5" modified="2017-01-18" version="1">MSAPSASTSAAIPPAPADDERLLISDQKDASSIWAIKVPNFLLRRWEEVQEGGIELGRLLVDNSTTPPKVTLRLTHPNEHEVEGQRAKRARYDTEGIPDEFDVNIPVERSKNTYVFSETKKVYEKGSGSGAGDRGAGGEDVKPGVKAYVPRDAWGRKKRDKANPKLVARVDHEGHVQPVRNAKYLQLVKERGLDAEKSKRPIVRMEDTGLSQAEQNQLASGFKSANSKFGSNMILSNKPSGERFARLERHELTDRIFHCFRDHPYWSLTSLKQTLEQPEAWLREVLKDVSEQVKDGQYQGYWQLKAVWKEGNWNGAQGEGVKGEVKDEDGLEPFVKPEIMDEDEDEDDDDDMEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K653</accession>
    <name>A0A1E3K653_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-dependent bile acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035200.1">
        <property type="nucleotide sequence ID" value="XM_019172258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189283"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="448"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="677"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1040"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1308"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="918"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1569" mass="173889" checksum="E0333F769AF59300" modified="2017-01-18" version="1">MSLSQSETETLLPSEVFSHHLDSADQDRPVKVDDFKRNVKICKAVLGLVLPVTLALEIWNLVLSSGELAGLETRDRAIKAAIVGQVWIDGLGTAAITCLAFLYVAALFRTITIRTLSLTPEIQHASLHRALCQLGFSSTLFLIGLHAVPGIAYTIITHLSPPTLSAAHGTLLRHLRTAALVATLLAVGLMRRGPKLYFPPPRLGTGFGLSNEKEEKEDEAGEDERVVIKLTPAAEEADPLASAVTIGQQQHAIPSEPASNVFDYDNSAMLVFVVIGYMAPLAVRSAYVDSLQQSDLPMLEDRTRNSGIDDSVFSADRKDEAFIPENKIGSWQLVKLLWAGKGWTVFISFALETTRNLISFIQIAAMHEIIDSFNQPAGSDKSYAYLMCWALFFGQVINVLLSAYCCVRENYMLHVPVRMSLSSMAILRTTDAKALEAHNVDVDDKTQDNRGRSQVMNLLSIDANTVASLATRLWDFANGMTTLVIGTGMLYKLFGVSAFVGIVCVPLSTPLSWLVSKLIYKCDKEWMRARDARTGALKEFLLGIKVIKLNAWEPYFGARVAKLRAHEVKWQRWRFTLGTAFNVLADQLPVLSLLITFWFHTKVMGNSLDAATAFVALSIFGRVKDGLQAFPQVLQNILTSRVCLGRLSRFLSQPEIDADRWQNASRRISANGATITWPAADGIKVEESGRFKLRDVDLRIPEGKLSVLCGPRGAGKTLLLRAFLGEAKVENGTVFAPRSLPDATPVLSEEESTCIQWTTEMWLNDSVAYAPQQSFIRHGTIRDNILFGQPMWEERYREAMRQAALMADLDMFGDGDLTEVGENGVTLSGGQKARVNLARCLYSRASTIYLDDILSAVDAHTAQYIFAECLQGGLLENRTTILVTHHVRLVLPAAAYIISLTKDGKVDQACSTSDVKLGELELEDPPTSPSNDEDLNTRSNPQRKLSVKQSDKQAQSQDVFKIPRASRQLYREEHREVGRVSRNHYFLIFRAAGGKGYWTSLFLIFGGLRAITICRSFWLEHWSADPSPEHLNYNLAIYTIIVFFSISVGAFRWIWLYGVKNVGFYSRGSRLIHDVVMERLFSAPLQFFETTPQGRILNVFGQDIWRLDSNSADAFGRDSRKSMRPREILSLIIVCQAVALITLIFGIPLYWVSGHVNKLRSDIRRLTATASSPLYSLYNEAIDGVVMVRAFGQNKLLMATMKTLNNRERVAWVANWWVSAMVRSVTSVVITATGLLLVGQNISASQAGLILSFASLVSSGLFNLMEQYSQLEQTFVSAERVNYYINMPDHETEEGAMPPKEWPTSGKIEVQDLSVRYASDLPTVLNNVSFSIEPGHRVGLVGATGSGKSTLALALFRAVGEQEGRILIDGVDTSTVLLPELRKRLNMVAQDGILCSGSLRESLDVTGQRTDSEIYEALRKVHLISGDMTEAETQENPFTDLDTYVAIEGANFSQGQRQLLCLARALLKDSKILVMDEATSSVDFATDAKITATIKECFSGITMLVIAHRLATVMSYDRILVLDKGQIVEEGKPEDLIRDHTSRFYGLCMAQGIEEYNSLLAMVSGEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6M3</accession>
    <name>A0A1E3K6M3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035370.1">
        <property type="nucleotide sequence ID" value="XM_019172428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6M3"/>
    <dbReference type="GeneID" id="30189458"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8662" checksum="9349D0ED1E264BD8" modified="2017-01-18" version="1">MPSERIVEELMDLRQENIAFFGVAEATTFVIPDFDYKYGFRGALPVNNETSSDEDTHSNAALMRSSSTRSIINTVGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6N9</accession>
    <name>A0A1E3K6N9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035665.1">
        <property type="nucleotide sequence ID" value="XM_019172723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6N9"/>
    <dbReference type="GeneID" id="30189756"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="95"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="370"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="689" mass="75139" checksum="B67139EC0021906D" modified="2017-01-18" version="1">MAELTPDAISDTPLDLLINAIAGNHTHHENIDQYLLPASDYVSSKRSRPDDIYDPPRPLKLARTAGATASLSSFFALHHEEGHTIDSAHASHVNTVEVWHPTTGQKSYGKERRMLNPPPIVRFTGSLAHRVIAATMSAYTSPPNQPPAISGTNTLRLGDLSSPTSGLLLAQNQKHPNWRRQKLRYAALNAGFGGALTTSRSTADIKDRFLLKEGVTFPGIWIGENTGKMKEFNLELKIFLGSDDPAEDGQEHHAEERTSTMYEAPHPSNSAEALSEILEPDSGSHHPLVETIQNSESGLGHDAIHSDHPEAESSGSLQEPEPSRQHQDTGSQEGPLQPPEEQLLGTFTSPSLRIVSKPSTKTSKARSMATCFSHDSAFSLWTRLHGQTVRTRWMNLEEKFNQDGPRLTARTAKWTPFRFEILDRAPFTRLARTSRGRPVNNEYTDATKLTYGSTVLLVDLQTGVKSDPVKLVKIEQGKYVVGGDVGQPVSELQRVGLVRAVSGEEEGGSRWYLSAPGARVGGAELFKDSSLGIRARVKPGRKSKGDGKQNPGEQPLAPSFMQDEHNDVNDLGGLGGRTLEESITLSDPSSSVDQPASSSEDANADAETPQSISAKSLNARRTALAAAVLAENEEGATQKLLSWAKAERKEELVRIEEEDGEGEVREVERRVHVDSVADWMSWTIGGVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K718</accession>
    <name>A0A1E3K718_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035571.1">
        <property type="nucleotide sequence ID" value="XM_019172629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K718"/>
    <dbReference type="GeneID" id="30189662"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14527" checksum="AA6F314D02ABBABE" modified="2017-01-18" version="1">MADREGWHTVELRIPFRTPEHAVIARRALDVDKEQNAGMVHREMSVEGDILVVNYYTTTVRLLRLATNSFLSSADLVLRTMSSFAPDPSDRIPTDKELEEIRREANRSTGMGGGIELKGDGKGAGSGEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K736</accession>
    <name>A0A1E3K736_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035528.1">
        <property type="nucleotide sequence ID" value="XM_019172586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K736"/>
    <dbReference type="GeneID" id="30189618"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="46988" checksum="E0F7513B3AB867E2" modified="2017-01-18" version="1">MLEEKYIGLGLALGGTFLIGSSFIITKKGLNDAAARSDEYPHSHQRSNNSRSASDDLAYLQNPIWWAGMITMVVGEVANFAAYTFAPAILVTPLGAMSVIIGAILASFLLDEKLGRLGVCGCAACIIGSVVIVLHAPSDKEVETVDEILSYAARPIFLIYITFVGVFSLFMIYRVVPTHGTKNPMVYLSICSLVGSVSVMAIKGFGVALKLTLSGNNQLTHVSTYVFLVVVVGCIVVQMNYFNKALDTFSTNVVNPIYYVFFTTATIIASALLFSGFNTPGGVNTISLICGFLTIFMGVYLLNISREPETPHPTTSLESGLMNPRMSMSGRLSMESNGAGFGYGAVPGSSYAADGSLQSAGHGRRSNLYRAQNSTLFNAFEEEGVPLGELPEEDESSDDEGGRRGQRGQQGPGRSLLGGKKGREGDVEGGRHPAYQDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K766</accession>
    <name>A0A1E3K766_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035784.1">
        <property type="nucleotide sequence ID" value="XM_019172842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K766"/>
    <dbReference type="GeneID" id="30189881"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="533"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="782" mass="85465" checksum="4B89AC0B62D9F650" modified="2017-01-18" version="1">MSPNVAALKDPQGIKRRVKNYFGYTDTTPKTISVTSWVTQSTPNAKEGVKDYVLSLFPFIQWVPRYNFTWLYGDLVAGITVGLVLVPQSLSYAKIANLDAQYGLYSSFIGVLTYAFFATSKDVSIGPVAVMSLETGNIITAVQEKYGDLYDKPVIATALAFICGFIVLGIGLIRIGWLVEFIPQPAVSGFMTGSALNIAAGQTPAIFGLANKFNTKAATYRVIINTLKFLPEASLDTAFGISALVLLYGMKWGFTWLGNRYPRWNRLCFFAQSLRHALVIILFTIISWRINIHAPQNRISLVGSVPSGLQHVGRPYIDKDLLAAIGPHIPVATIILLLEHISIAKSFGRLNGYKINPNQELIAIGVNNTLGTLFSAYPSTGSFSRSALKSKAGVRTPAAGLATGVVVIVALYAVAPAFYWIPNAALSALIIHAVADLVASPKHSYAFWRVSPIEYIIFVGAVLWSVFYTIESGIYWSLATSIVLLLLRIARPKGHFLGRVRIKPQNDAQQTRDVYIPLCDSHNQDVPVENPPPGIIIYRFEESFLYPNASYINDRLVERAKSTTRRGGDHHAIKAGDRPWNDPGHSKKDEEAERKVESEKPLLKAVILDFAAVANLDTTGVQNLIDTRTAMEKWADGPVEFHFCGILSPWIRRALIAGGFGQGRTKEGAALEVAPAVIENLENAASPPTHEREEDGLFLVNGVGKAHQAGGSDSARTSVYDEEKSLGSSSSGASTPPRVQNIHEADQRRGSDKSLPLLDRTTPFFHFDLADALNSLHLPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7Y7</accession>
    <name>A0A1E3K7Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035199.1">
        <property type="nucleotide sequence ID" value="XM_019172257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7Y7"/>
    <dbReference type="GeneID" id="30189282"/>
    <dbReference type="OrthoDB" id="2575540at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="168" mass="17539" checksum="DC035DE7DC586E00" modified="2017-01-18" version="1">MGFLDFLPCCGPRKDKIKDSEAVDTTTLLPPTRPESIVSADSLANYGAAEQQGLTDEQMSRIAAIGRQVGNHMLPVSTSPQNRTSSPIRRLSTSSIGSSRPPSPSPERPDTNPLNGKIQSSASGETLKPEGDEVVRKNLFAGGNPGGGGGKGKKGKKNKGKGKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBD1</accession>
    <name>A0A1E3HBD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000063">
        <property type="protein sequence ID" value="ODN73642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027783.1">
        <property type="nucleotide sequence ID" value="XM_019180234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBD1"/>
    <dbReference type="GeneID" id="30197477"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN73642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="40486" checksum="443576B0CF0A9056" modified="2017-01-18" version="1">MADLETLFNSPPHSPPPPPPPRSRSTTPSTPLRPNRPEQEALFFSPSASQFGSPAASRGQRWQPAQAFSDTMPADADADVGTEVGVGGGGGMDQVRRVQGRREERAAEEGGGGGGGIVRVRHAVNVVDSVDPLPRDTFASRPAALTSGGGGGGGGGGAFAGVGVYGAITDPLAGASGAGGDGGDGGEGEGEGGEKRRRPVAKVDADRLLSETTGLPALMRSAKKFRTRGKGREKDDLRNLLHMYQMWAHGMFPKGSFAQTMERTEKVCRTRRMESAIGGLSDAFHGRRSPSPPFSPVASPTRSRSRSRSRSRSRSRSRSRSRAREASTQEPLFTEAGPSAASAGGADGWDGPDMDELMAMEAQEALEGQQGHEGAVEEDEFDGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD92</accession>
    <name>A0A1E3HD92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027826.1">
        <property type="nucleotide sequence ID" value="XM_019180197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD92"/>
    <dbReference type="GeneID" id="30197439"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN74297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="142" mass="16404" checksum="02CAC61F5E2A05D9" modified="2017-01-18" version="1">MSRKFMRHALWAFDFLVTYHGNGDRQDALVLFEYAEMKEAIRKEKEAKAERWGVILKSPANRHRLGLAMLMTFLTARTLTDIYADVWLIHHHLLLEADLVVDPTEMQTFSMRSKGLLVWNTVQQFEGAYTTFVEAVALDSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HGM5</accession>
    <name>A0A1E3HGM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000058">
        <property type="protein sequence ID" value="ODN74906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027841.1">
        <property type="nucleotide sequence ID" value="XM_019180184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HGM5"/>
    <dbReference type="GeneID" id="30197424"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="1">
        <location>
            <begin position="200"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="481" mass="53264" checksum="9E9DEF5BE5004C86" modified="2017-01-18" version="1">MDSEKLLAAWGRARLLGVLLFTLLFASAAVIFTGLVLGTDIPTEKLLSPSVAKTLWNPSGSPPDPTVVHTKHLGGTPGYQVLEHVWVGNGTIYMYAPDRSKLPSKSRAVSGETGWEVFTHPTGERIEHAKNALKLGGTTIFVNDGADTSQWHYLSSYYHLIGEIFLGSVAAIASLPSKVGIPQVDARDWGERVPATPERFIIPWKAAEGWRDEEGLGEMVLRGIFGDKFLEPHDWAALSDPDNEHNGWVYLERVVITDRWASHRHNPLSEALNKMAASVFALPHSPFFFTPSRLTLLPHLGINLSPHRLAPSKLSTGEGVPKVVYVDRQGTDRKLDDESHMGIAVVLAELDALGLARVGHKKMERLTHVEQVEAVADADIIIGVHGDMLTHQLWMTEGGVVIELFPPDSYLPENQIVADVLHHEYIPVWHDVALTRKEWEGLPRQHGHGALYDGTEVTVDKAYLRLLLEEVLQRMTDERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJD8</accession>
    <name>A0A1E3HJD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_08053</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027973.1">
        <property type="nucleotide sequence ID" value="XM_019180026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJD8"/>
    <dbReference type="GeneID" id="30197264"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="878"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="242"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="955"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130034" checksum="F69E0FEC8F4F3811" modified="2017-01-18" version="1">MSKNDAPLPFTSARPLPTRQQTTGTLKRGKTLTRPERHIAPAPLIAPPEAYATTAPASSTTLDWWRLWSYATTFWAPPVVLGWFGIKEQQSRQAWREKVTLCWIAVVMGGIVGFVTMGLQRALCPEDQQNNSSFLRLGETDLTVSISGWAFNISSSLTQDDVDFYSLSTQMPGQDVTNLFIRNLTDFPSCTSDLRYSTTPLCASSPVTGITENGTLQACPLAKLSDTVLSDLNVQNTSLQEGYSWDQVSALDDYMVLDGFVLNMSPYLEANPTAIEGDVVDAIIRQMTSNQSTSGKDTTRLFYNTPTAREAISCLQERYSAGKIDKITPGCFVASLFLYVSLGVILSVVFVRFAMACVFNWFLSARLVLPPKNLSRTAISPAVMPEGANVSVNNRSGTAPWAGGAAVPTKNKLNKLGKPSPSRGPSPSPSPTTTRQNTNNPLISLSRVGAELFAVCLITCYSEGEDSIRGTMESIAATNYSDARKLIYVVCDGMITGAGEKRSTPDICVGMLDADPRFGNPQPMGYIAVGSGAKRENRAMVYAGHYVTRNGHRTPTLIIVKCGMPSEAHEKKPGNRGKRDSQLVLMNFFSRVTYNDRMTPLDFDMFRKVQTMMGVTPDYFEVVLMVDADTRVYPDSLKHLVNCMHHDNMIMGVCGETRIANKRQSWVTAIQVFEYFISHHLVKAFESVFGGVTCLPGCFSMYRIKARREEDNDWVPILVKPEIVNEYSQCEVETLHEKNLLLLGEDRFLSTIMLRTFPRRKNMFLPQARCRTVAPDTFSVLLSQRRRWINSTVHNLMELVRVRNLCGTFCFSMQFVIFMDLVGTVVLPVAICLTIALIVSSIITPPTSFEEAIPLLLLAVVLGLPAILILITTRKVIYVAWMLVYLLALPIWNFVLPVYSFWHFDDFSWGETRKVEGETVGKGHDDSTAVFMGTTIPLRRWEDWEKSRLRKIRREEKRRRDMERQFGAGFHGGPKSPNGNAPNGGGGGGGGGGLGANLGVGGPKAWTRSEYDSDSGSVFSSEEDMWGGEVGGYNENNPSFPPPPIALPPNSPAAGPGETIGMDEMAAMLDSGFDDTAAPPPRTLRPLKNPTSPLHRHQHDFNTPPAAQMRFNLSDTQPGSYVSIDRQGEEGEGQMPVSGGSVSSSVESRPQGGGHAKKRSGGAGKGYGPLGPLDERSYPGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJF0</accession>
    <name>A0A1E3HJF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_08076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027995.1">
        <property type="nucleotide sequence ID" value="XM_019180048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJF0"/>
    <dbReference type="GeneID" id="30197287"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN76480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="552" mass="59564" checksum="E80FFC011220896C" modified="2017-01-18" version="1">MGGAVFLGCWLMGGSWLVGVLGVVSHLSHWWFLEFVESPHMQKLYGNRLRKDGGLTKTLKSNLPNSTAVRQAVSKHPRVSRVVSEVNRGIEKVEERVRGGVEDFLDHARPMLDGVVDDARGLLQQSRERMIITRVAKPKDLTSFDPSSYSLQIPTSSSSPTPYPAFHVGQPIPISWNAPSNHSSKDWIGIYRLGSCKSEIVTKISSVGKWVGVYEEEWEGNEHVTPESEGKKADAGMVVLKGKQLPWQPGQYEIRYHHDGKHNVMSRLAPIELYVDKPRASRSSRVSSPRRSSASLSSSPSKSVKTAEIKEEVGVKEVRETMMKLVCLALEGEEELVPKAAKGKAVMRLASVPTAASQVSPGKALNKPTLSYTPELDEGDEGEDGVEADAEVEDQGSLLGSGVAGGEKRAGKAGKVDKKGKGKKGGVGIEDEVTRTKDTFSPSNLASADNPHALDHLASLADRSAVPQRSILGLADNDSTRDPGIDRTVDPDSDSEPEADDFTIMTETQAKRIASLAKHAFGVELDADVVVSEANVGALARRVVGAWSLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLT7</accession>
    <name>A0A1E3HLT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_08044</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028016.1">
        <property type="nucleotide sequence ID" value="XM_019180017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLT7"/>
    <dbReference type="GeneID" id="30197255"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN77309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="41863" checksum="56D007A1B3DB87F5" modified="2017-01-18" version="1">MTIAVNSIPATKYEAHYDPKKVLTHPDFKILEEGAPELDSREENIACTYNPQHEVKMVRKGKVEPGEGEVTVHVKATGICGSDVHFWRHGAIGPTMIVSDTCGAGHESAGIITKIGPGVTQWSVGDRVAIEAGVPCGLADCGPCLTGRYNACPSVVFFSTPPYHGTLTRFHNHPAAWLHSLPDNLSYEEGSLCEPLAVALAGLERAGVRLGDPIVICGAGPIGLVTLLSAHAAGCTPILITDLLPSRLAFAQSLVPSVIPVLIDRQDTPEQVASRIKEKAGVELGLAVDCTGFESSIRAGIYSVKFGGKVFVIGVGPSEQSYPFGYCSANEIDLQFQYRYANQYPKAIRLVSSGLINLKPLVTHRFELKDACKAFGVAGDPKARAVKVQVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1S8</accession>
    <name>A0A1E3I1S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CMGC/CDK/CRK7 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028326.1">
        <property type="nucleotide sequence ID" value="XM_019179709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1S8"/>
    <dbReference type="GeneID" id="30196932"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="889"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="918"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135166" checksum="528E711E637DE37F" modified="2017-01-18" version="1">MSTPNHRPFKRESWRPHQPPQHPAQHGQSSQGPQGQGQGQGQGQGQGWGRGRAGPRDQGWNRGGAGGDGRGNDWERERERERERERPGRDDGWRAQGKRKELSPERPRANFVTQSEKERQEREARRHGGKDSERQGFNGGGGDWDRDRERDRGRERGRGREESYNRPPLPTSERPPGQSGNYTNPPVPHNRPLPPRDQQGPPTKRRRGGRESPDYGVGGGSRDAPSSQRPVSPSLSAPSRSRDRTRSPTLSHSQTHRQRSPSPADSDRLSTTSGWSRRAHGRGRDHDRDGGYDRPRENRSDRGDSSRPHSDPRQHTPHAHTQNRPPFPHSQPPPDRSDRSGDNGWSLRRRGGPLPPPAPFTPTPNRFGPGPGPGQGLNGVPTGPASGRSGRGFEDRRFDDRPPFGPNANYPPGPGPLGPSGPSGPPGPPGPPRNTGRDIPMRQWGRPPNPSGDAPWDDRPPSRPFPPTDPSPSFNREPPNSEGNGRWSRSDMMDRERDVRDGPSAGYGGRRGGEEREFGREQAEKYGYDRIKPSRALRGQPPSKRGSPAPSEPSGYTPPRPVPISSPRHALSPREPERLEPPHRSPSPEPRYQDTYPSYPSPRPQISIEAPTSFAEYIPRPEDPLVPIPEPEPQVEEHQPLQRMEPLKISFAPIVPAKAKGNGGTEGKGGWKSLSGVGGVGIASGVEKRKLSLFDDEAEDEAGDGGSQKESQAEVQAATAIEKNEQATLPHPDALIHRLALASQRYNTLLSALPTFLRAAFDAYATLLPSPSSSVNPRHPLPPMDLFLDEFLNKRATMDEITRVEEVWDARMGWEAQEEEGRMYLEQVGKGGIVQGGEERDDLDGEKMEVDAGPIVDVLAQPTPAPSDTSAQPPEPAPVPEDIAPLPVYQKITHVGEGTYGKVYKARSTITGQFVALKRIRMEGEKDGFPVTAMREIKLLQALKDGNVLKLLEMIVEQGSVYMVLEYMDHDLTGLLSHPTFRFTPANIKSLSHQMLAGLSCLHHHSILHRDLKGGNILINARGELKLADFGLARIYEKDRGRGRREDYTNRVVTLWYRSPELLLGETVYGPEVDMWSAGCIILELFTTKPIFQGNDEIHQLETIYSIMGTPKESEWPGVKALPWYELVKPKEVVGSKFRSSFAKWLSPAGLDLVEGLLFYDPLKRLSADSALKTPYFTSEDPTMEKPTQLEGIGEHHEMTAKAEKRRRRMEEGESRHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I534</accession>
    <name>A0A1E3I534_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028345.1">
        <property type="nucleotide sequence ID" value="XM_019179657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I534"/>
    <dbReference type="GeneID" id="30196880"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN83773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="406" mass="43950" checksum="F6CA3E8D9E7A51FA" modified="2017-01-18" version="1">MAILRLAVCISGVYATFLLWAIAQERLSKPFPSIHPHPDSQPNDPSEPLPGDKFPSPIFLNFAQAIASSLSALCYLVFNAWREGWNGRGMGKVLGLNDLFGGERKEENGVFEKAGTEVAPKAKPGRKSLLALLVQVSIFQTIASPIGFMALRHISYPTMVLGKSCKLIPVLLLNVLLYRRKFSSHKYVVVALVTVGISMFMLMAEAPKKKKGGADSIQGLVLLLVNLLIDGLTNSTQDQIFSSYPTFTGQQMMFTMALTTQIILLPLLLIPLPSHPIALLANLPLLLANTLPTSSLTFAPPAALESISFLLSHPAALQPLLAYALLGGLGQLFIFETIQHFGSLTLVMVTVTRKLFTMLLSVFVFEHKLTPGQWGGVGVVFAGIGVEAAQKRGSGAKKAEKTDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICJ6</accession>
    <name>A0A1E3ICJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028707.1">
        <property type="nucleotide sequence ID" value="XM_019179351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICJ6"/>
    <dbReference type="GeneID" id="30196560"/>
    <dbReference type="OrthoDB" id="10642680at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="268" mass="28899" checksum="B78422DA1E2CB6EB" modified="2017-01-18" version="1">MSSTTNNNSAASEYNMETRPAAPNPDPNANPNPHPHPESNLPVRKGSQWSFRVLAGRLLSCLPEERSGQEFRAGLVDLVLMVALVTWWFAMSGLKEWRPIGLLCLPYVVGRWRWCTAPYGTRVFDASPAEAAEAEAAADTAPAHVAPAHAAPAEAAPTHAAPTHAAPADTPADTHPAQSSQSDRIEALLVSQAHIISELRDKLQAVELKVDKLQDKLEAVESKVDKLGDKPKAPSFRSAWRPGPRFTGNREGLSTGWSLGGLRGGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDA4</accession>
    <name>A0A1E3IDA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028757.1">
        <property type="nucleotide sequence ID" value="XM_019179276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDA4"/>
    <dbReference type="GeneID" id="30196479"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="40424" checksum="2D97F84C562F3215" modified="2017-01-18" version="1">MTEEDPSSPQRLPEDVMYVLLGHVGATFIPPYLAPLLRVSRFFHKTLIPFLYRLAILSRRNVSGFFYWLSYTDKIDDDEREQWWQGDLADKKSAVARRLAMLGHVQGVYFEDYVTARMFNSGVSAFLAQGLDSPPLSWYGYTPSSRDDSSPARRLLFYGRAPTIVHLSHKFLGGLASTALKDEDRRVQTFQSMLGPFGVLSIRQPEDLRRPHLSYVRSYVGPICRRVKPLVLLINDYDNSGLAEILSSSQRGIAMRLRGSADTRSIAQTDEVVKFLSREPLFYIIYNFSMDEAIYDHSKGERVRNLILNRAFAAASQSPQERIVRLKVIMQGPQSDAATLPRMMYDIFEMMKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDU0</accession>
    <name>A0A1E3IDU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028778.1">
        <property type="nucleotide sequence ID" value="XM_019179297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDU0"/>
    <dbReference type="GeneID" id="30196501"/>
    <dbReference type="OrthoDB" id="2559962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN86595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="37103" checksum="7F8ACCBA1BD9B5C9" modified="2017-01-18" version="1">MPSPVPIIAITGINGFVATELVLLFLAREWHVRGSVRTPDKAAAVKTHPAYERFFQQGSLEVVVVEDLDESDLGPLMEGVQAVAHLAAPLPKLDDPSLTLDDFKRPIVEPVLRILQQAHKPSSTIKSIAFMSSAASSVDLGAPPGKVYTENNWTPYTDEDCKSLDPHQNPMASVIWYFTAKKQAEQAAFEFHKIHQPAFSITTFCPPMIYGPAHYLQPGTNMSTVTGSQEGFVSLFKGRDAPLPGQFFWSFVDVRDVVDAFHVALTKTVSGRFLVSGHEYTWQEFTDKLQLIRPDLSSFFPLGQPKCKSEGGGYTPAKWAFDSKKLREELGIECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IF96</accession>
    <name>A0A1E3IF96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028869.1">
        <property type="nucleotide sequence ID" value="XM_019179111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IF96"/>
    <dbReference type="GeneID" id="30196308"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30945" checksum="0828398C015ECE7A" modified="2017-01-18" version="1">MPARPLKSALKKPTKSFETPAAGPSKPSFSANKPSQGKPKAKATVSIAKKPEKLRGPDLASDSESNVSGFENESGDEGEVVDEDEEMNTDEEIEKSKEPKKGKKGQKRKRAPTTAADFGATLTSLLADPLTHPSKKAKPAKPAVDPKKKSTTNPILALSAHKPPTKASVSLEAKAKKQIRVDKEEKEDRARVKNVVEGWSGDGVVGGQEFEKNLRKTAQKGVVKLFNAILLASKNAEASDMSLADRAKVKPEAAKRKEKDNILGRGAREDVLTKESFLDMVRKGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IG73</accession>
    <name>A0A1E3IG73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028985.1">
        <property type="nucleotide sequence ID" value="XM_019179067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IG73"/>
    <dbReference type="GeneID" id="30196261"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="131"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="629" mass="71308" checksum="F0E6A736BAB80680" modified="2017-01-18" version="1">MSIIPPDSPGSNHSFPGGSSLKPEKHDIDHLEDVDVEASRDQDLRSRNRNVSAKIQNPLAGLSKGKLLDLADQFTREHDFEEKQDLFRRAALVSQNPNEFELIPELTEDDRYWLRREITNKWDQTRALYFLVIVCSIGSAIQGWDNTGANGANLSFPAEFGIVDNTWLVGMINAAPAITVGSVSAMLTDPINHYIGRRGTIFVTGLFCVFPVLGQAFAKNWWELFICRVLIGVGMGMKITTIPIMTAETAPAAIRGALVMSFQLWVAFGILAGFCSNLIFYRIGKNAWRVQLAAAFAPAVPLLFLIWFAPESPRWLMKKQRYPKAFKSFCRLRKSEIQAARDMFYAHCQLEEEREVFQGTTYFTRLADIFVKPRLRRANLASWVVMLSQQLCGINIMSFYSSTIFSEAGYNTRQCLLASFGFGLVNTIFALPAIWTIDTFGRRNLLLTTFPCMALMLFWAGSMFFLHESNSARVPVLALAIYLFTAFYSPGMGPVPFVYAAEAYPLTHRESGMSWAVQQNNMWSAVLGLTFPTMLAKFKPWGAFYFYGGTNLLAWTLVFFFTPETAQRTLEELDYVFAVPVPVFAKYQATTFLPWFIKRYVLWQKSAHLEPLYKLEGVASERTEVERFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHG6</accession>
    <name>A0A1E3IHG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028936.1">
        <property type="nucleotide sequence ID" value="XM_019179018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHG6"/>
    <dbReference type="GeneID" id="30196211"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000154">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="257" mass="29649" checksum="3AD4E6EE4309F907" modified="2017-01-18" version="1">MADYRAILDEEFEVLDSIFPDETERTSDTSLSIRIEPEEPNSAHPLTLNLVLTYPPTYPDAIPEIALESISEAEGEFTESERAKVLAELTTIAKSIGMAMSFTLASAAREALVVVIDERIKWEKEEDDRKTREYEEAEAARTRGTPLTPSAFQSWRLAFCRELADKRQKAEEARIRALPPREREDYKKRQARLSGKQLFESGNKAAVVEDDNLYEEGVEEIDLRKYTREEREEERRKEEEEEERRRRGLVEGDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHJ9</accession>
    <name>A0A1E3IHJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIOS-like alpha-solenoid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029142.1">
        <property type="nucleotide sequence ID" value="XM_019178865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHJ9"/>
    <dbReference type="GeneID" id="30196043"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="2">
        <location>
            <begin position="710"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113468" checksum="5DE9C7116C09E6DD" modified="2017-01-18" version="1">MATESRRMAISDPHGSIPPRFIVGGQLSQMVSGDIKMYEWRREEAKMGMVGLQTEVGQIKTLAWSPSPVHKHLIATGLSTGKTLLINLSPSTLSLPVQPANSPSTVASLTVKHTRPVTAISFSHIDPNYLATGLDRHRSDSSLLIWDVHDAILSSKLEPDGDTWTRPEPYLKSTTTTKPTSSEPRPIQAYCPSEAIQAVSWIPSSPYSLLASSSNKAIRLYDLRDPTPKEGASAGTAGSAAQWSSRAVHFLTPNPKYEHSFASYEAPPAGGSSTVRLWDTRRPGAEILGWEMPGNVCGMSWLDGGRLGVGSKEGGVRVWDVVRGKREEGENVKEWVTLGGMRQIVKPRQNLHSFAFTPTAQKGSPDVMYVLRDGTISIGPVGQAPLLTSSSQGDIAITSSALILINPDSPSTSPTTQSFPVAEKKDKDEKDEPIYRRNKFQLAPERITAILAERSSSRSASPSFTGKASYSQDPLSRSIVSEFERDKERDYYEADGEVINERDEIVGGYEGWRKVLSGDVSVVMRRRAGEGYGLDDLLLNAAVASRHPGKFKLAGVWEFIEHLTRTMTPSLSSSSAYNLTHQGIYPIWTSLGTQDISPTPLSPHLVNEKLSLDNRGRPEKEGKFRFLSGGDGSRSASMSRTSSHTGSGTFTPKETRERKASDRPTGTTSYLSPPSQEYLSAIASLNATRSTLHDTSLHPGIVRASVGGERTDLRKLILTLCGENGDGWDGGRRGRGKGEVERLVKQGERSKAAFRAFFKGDEEGTISILMSSEDQNDNLLGSTIAGFMAQSASARGSEYFNSHWRNLVRRVDDPHIRAILSRIGGDDWESVLEEENIPLLDRMAVAVQHLDDYEFSTFLRGRMNRFTRSASLHMLPLAGLAPPALSLLSRFLARTGDIQTTTLLSAFFPPGKMTGAEKHMRERWREAYRSMLDGWGMWGERCAFDVKWGELQRALGGEEEGENRMGACPVCNNPIPKDTESRLHRKNAVRGTPNVGIPNVSSVCYTWIPIDHLQRSTISLLISVTQSMPHMCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHK9</accession>
    <name>A0A1E3IHK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029152.1">
        <property type="nucleotide sequence ID" value="XM_019178875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHK9"/>
    <dbReference type="GeneID" id="30196054"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32185" checksum="50439789AF43DDD1" modified="2017-01-18" version="1">MTSTAFTAPSWYKSFYNLFPLVTLPQDDELEWKSHAKPLGENAAVLWIHPSSSNHPYHRSWLSSNPASVRTQLLFLLRQTAAQPRVVFREWPNESSAPKSTLPALHLPSQDRLLSTDEIRPWLEATYPLEGKNKDWQNLPSQSAYDSALALSTLITNQLLPAYLASLPSRPSNWYLYFPTPPPLWAGLTTPLPASLTGDEREVDGEEVIRKGVEVIDALEGIVGGKSGEEKWMLDAKAPGALDALIASHIYVLFALPLDSPLREALDGKKKLERYLERVLEYAERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN3</accession>
    <name>A0A1E3IHN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029178.1">
        <property type="nucleotide sequence ID" value="XM_019178901.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1E3IHN3"/>
    <dbReference type="GeneID" id="30196085"/>
    <dbReference type="OrthoDB" id="10468925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="350"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="552" mass="62204" checksum="61A3A78DD79882BC" modified="2017-01-18" version="1">MNKRDQPRSSSERGMLFGGVSEKSAEITIFIGCEQDPQLQGHVIIRNDATTEELEVAIANHIRLPLPSFFITWNSQRLSRLAPLSSQGIVSFSTVHVFPIKAMQDKHKADQEKNKKDKAARYYVGRDGSVKVRRRDRQKAMEERLRKSDGDQDEEGKKGLPGFRQFCNAMGVSDEPRPRSSDPFRPPHLSSNKKRPRPADHDDFLFMGHEPVESHVSRHTEVTSVVPPAKREADGCRGPLTLPSRHLHPETVSSFPGVSSALPVFPRVSPGYIIQPNNHLPSPPRDDSATRRQVDVFSDFDDSQCELRDYDPPSYVQREEGMVPLTRTSTPYHYSSAQVRLSRERVFHSPSLYSTPSPSDPPIHITPPSPVNPPPSPVYKPPSPVYESLSQPPISRSSSSLVPVPVRRSVFPRIDHRTSDRPSSPRVLPDRPVTFCREDRSYPPTEWSHVSSLPLRSGERPRLPHGVYPTARDGRRSNFPISPPRSSSADTVDRYRTRDERYDLLPLRSISGLFPPAEWGRFWQVCTLGSSSRSHEELEATTGWQSGKGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIP5</accession>
    <name>A0A1E3IIP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029278.1">
        <property type="nucleotide sequence ID" value="XM_019178795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIP5"/>
    <dbReference type="GeneID" id="30195953"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12741" checksum="82940F7C36FD63AF" modified="2017-01-18" version="1">MPLSEIVSKELLAYSKTDFGSCENSLYANATTNNGDYRRGIDEGDREDMEIGMREDRAEDQSREHNSGNMPAEGGLQSAGDMKRRRDLYTELLWDRFQSRPRPELYQNANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIR0</accession>
    <name>A0A1E3IIR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029298.1">
        <property type="nucleotide sequence ID" value="XM_019178815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195973"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="2060"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
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            <begin position="1826"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="541"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
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        <location>
            <begin position="831"/>
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    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1085"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1133"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1185"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1225"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1314"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1445"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1547"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1583"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1630"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1652"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2067"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2134" mass="220769" checksum="EC16EEECD73BC19D" modified="2017-01-18" version="1">MFGNNAFGALAMDSDASNAAGPSSQVIEGEELDVSWLKLVKRNGGVDVRVSEKIELEGLPNECNLMTVVNKWGLLIVGSNSDIRIHRLVDVHKAINEAPPGGKTLPEIAPAQTVSLPARPVWIRSAMNEERLVVATANGAGIYVWNLKDIIAGSTNPLHSFSINIPSRLLNVLPNPSSDSLGRLVALVANEGLVMADIEEGKLMPPVAGPFSSACWSQKGKQILVGKPSGELVQYTPDGVAKAEIPHPPNLNHRPSSIQWLENDLVLVTYVQNAQGMDSDPIEQYIVSRKNGSHSFVKFFDPLNNMGFPARSEDYRHYAGLAAWGSESKHLAFLISGAAPDIAVMNGHPPSGNVPPQWEVLFLDGSERGTMPVAKAGRDNTSPLALGFDFTSQEPVQQSTDGTLPDLAPVPRLLTFSQEGVIISFDVLNPDAGPYPGMITPQNIVSGDSAAAPSPAPAAKPASSTPKLAFGASSGSAFGQSGFGAAKPAAFGSSTFGSSPAFGQSSKPPSTAAPSAGSAFGQSAFGTAKPSGFGSSAFGQSPTPNTSGASTPSGGASAFGKAPAFGNAAQPAASGQSAFGQAATPSTFGSATPSAFGQSSTPSAFGQSAFGQSAFGQSSKPASPAPSAFGSSPSAFGQANKPASPAPSSSSQTSAFGSSATQAPAFSGFGKSGTPSTASPAFGQSAFGQKPATGAGSAFGAGGGFGQSAFGQKSAFGAGNGSAFGQSAFGKPAPSPSIEAPKSVSAFAGFGQTKTETPKAPSPAPSQNSNKDDFGLGGFASALESSKSTVSVPGLGESPPASPVGGSNKKPAGLEDDTPPNSPPVKPAAPAPSAFGAPSSSSSGFFKPATAFGNSAPSFGFNATEKKPTGPTAFGSGFAPAGSTSSTHSPGSAFGKPSAIGGGTAFGQQSAIGSGSAFGASGFGQSKPASPAPSASGSITGGFGGFAASKEAKGFGGFASKGPSLFGQKKNDEQKGDSAFSKPSSSFGTPKSTSAFGAGSPFYTGKTDSGSLFGKPTQTSAFTSQPATPVEEKKDDIKEEATLIKEKQEEKQEEKQEEKPPAEEDSKVEGEKQGEDKLEKEKERDEEVEGFDVPAPQPVEAKSPPPASAETLSTPAKETTTPPDTPAKDEEASNTSAPEPTKSTSPEIPVKDEEESTTPITLVSEPSEPESKSEADDGKDKTVDPDEVETLDPELEAASDVSAEKAALESSEGASGDAVAELLEEAQKQRTNDVIGNEHQDVFEEVGRDQKPATAVSASDGDSNEEETKEEVSEPAADEHTASSPEPSISDLSEEEQDAEVSGPEDQKDQQFVGEEEEVDEQEEEEDEEEGDEQDEDEDEEDYSEDEEEEDHEERHRRRSTSIAPDMSPIEEEQQLDEGSDAGEDEDEEDDAEKESSVKPKPSSLRSPPAWFATKSSTSAPTPPEENEPKSPSPSSGSSLFSRLGSATSTPSEEPKTSPTDAPKLPFNFTKHASRTSSPLSGPPLGSTTPESSPAKSVAAPSAFTGFGQKPTDASKPSGFGGFFKSEEVKPSLFGGFGQKSAEASKPSANTKESQTPASTAPSGFGLFGQPKIEPIKPPAPAAPAESLFGQPATAPVAAKTAAQPKSVFGNLGLGKPSGSSTPSAFSAKPLNEPQPQSSPLPSSKPASAPAAPKPEPTPHPSVPKAADFTDLSAPTRPALAERPSKVTQSGEKTMGSVAVKIVETLDEDLIKLKDVVASNAKFHQELRRRNAGTVDFDALVDVVEKQRTLPLSQLSQVQRLIDDLHPRVVKQQRIDEEAEARLAELRSKMLRVDSKVAQVERHLKAKRGQISGESLDLNPDQAAYRLKLRNAVQDTEDKLQELENSIASLRHRNEKQDEGHASLPPLERIQRSVRSVDAAIRERQQAINDLSRRIASCHIASPSGNRSLLTSRRALNFEPTKDAMAEVNAVLAGPSETKKKRLGKLKVAKLNKPVVARGEGSSGVRGASFTHESVSAGPVMIDDLPPAGHFSPPVSPNIAPAPELNDEAADLYLSTLSSSPPLAQPVPVPATSSAPTPAVSSPSAFGGIKFNLSPSFEGLSHESSLRRSGGSSSGNSLRPAAVKYVPGAASSGTPPPPAAGMFSFAPKDGEKVVTDEKKLPSGFFSLKDYMNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJN7</accession>
    <name>A0A1E3IJN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear pore complex protein Nup133</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029382.1">
        <property type="nucleotide sequence ID" value="XM_019178681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJN7"/>
    <dbReference type="GeneID" id="30195838"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="844"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="136204" checksum="E7018DBFBA598584" modified="2017-01-18" version="1">MFNSPSTRSRLNTPRYSTAPTPARSRLQTLRVQNNSPTPSVAETIRTERPQGEEKDKVYWSRDERHDIAALGKLPKEVAALVKASDLVNDPIIAHVDSKSGYAVVSTSRTCVAWNYAKRTNSTATTYSFPAPPPTTSSLAGFVPPILAALYTSTAEPGMILVSSSGEIRFWDSLSLALSNVDRYQEVFVELPEGDWVERIWKIDGSTFVLTTVTSQAYRLNITTSGGRATPVVVPLSRPSGMFGRASQVLFGTRYDREGVRSVASLGSEVYILASRSVQKWTFTSDSQKFVQEYDLYDAAGNAVSDIYISGTVALELDDIVAIGPESLAALVTYAEPHSRPTHAILTFSLQRASIPAIDRTLPLAYFPTPESRALDIPRLIVPQDSSVAFVRFGGAVVMKALDYETTYEETIHLKDPSNAFLAVDAVFAPNPTAVLLPASGGLMSLTALEPRASPEMLGQKSGATARLESKMQGAVWFGGRGDNPLDFGLVEDARGLGAGDVAEAAESVSAEVLSSSSRYAPVISELRLNLQDKLSRLKELLKFVHVNNLLSELPQTTRRKLSGDAEKVKGALELWDYQDRLLDQINSQPSKALLTSSIQTYFTTLPPAILPSSLSYSEFTSDPVRFFFRHNIPHLSTLLSVTFSQYQSAVSHLGSDDVQEKSAWLGEVNQIFIALERAAAQYREEEADLYVIDREKPAVEMWTASDELLDALEFLYASTESAIKERTRVLGSAIDEPPSSGRGGEDLRKEQILQGMLKRQMGWLAAALCTNMEDKCRVVVRRQMNDGASEEEGIAIKEKWDAMKPRVIRPLVTIDRIAEAFELAEHHRDFPTLVVLSNDPQAAQGRGEARIQIYIERFGEEFAFELYRWYIAQGQAYQLLTQDEIYGSLITRFFETHHHPELAWIHDVACKRYSHAAGALVDVLEGGQEAGETTQVGELEYRKIVGSIAKLAEMTDISMRGADEEKDHTFQQIGQHLSLIDNQASLLAYFLDLLPSHPRPPNPKHLSKHLAPILTLISTPADTARESFQALFIDLVNRLVIEGEALSLEDVVDLLVMKDNGDREEDAVDALRLVVLDQTLPKARSEVALISIWRRVYIRDDWMDISNTGGRSEQAQRSYLRQTMIYKVLKSLHSIPDFPTAAIIPPYDATIPPTSTELSARFPNFPPDVIRELEADYETEVGVLVRYVEEGGLEGRVKEVENLVKNDLEAEGREVHDVVLGGDDDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKL8</accession>
    <name>A0A1E3IKL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029432.1">
        <property type="nucleotide sequence ID" value="XM_019178525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKL8"/>
    <dbReference type="GeneID" id="30195678"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="733" mass="79815" checksum="D4051EE16E2B9716" modified="2017-01-18" version="1">MLPRLAARSLRSVAGPSRTRLFSSSIPRLADVTLTIDGKEVTVPQGTALIQACEQAGATVPRFCYHDRLAIAGNCRMCLVEVERSPKPVASCAMPVMPGSKVFTNTPLVHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGSDRSRFHEITGKRAIENKDLGPIVKTSMNRCIQCTRCVRFANDVAGVEDMGTTGRGNDLQIGMYIEKTMDSEMSGNIIDLCPVGALTSKPYAFQARPWELKKTESVDVLDAVGANIRIDSRGTQVMRVQPKVNDEINEEWISDKTRYAYDGLKYQRLTTPLVREGNRFVAAGWEQALETIRHGLVSSGAKGDEIQAVAGALADTEALVAVKDLLNKLGSENLTLDQNLGDAPTNVDIRSNYLFNTGIENVEDADAVLFIGSNPRHEAATINSRFRKSFLHRGTDFAVIGEKFDSTFEYDHLGTSGKDVASFFGGKAGNSFAKIWKDAKKPLIVVGSAVTETKDGAAILAEVSKHVLANSEKFLTSEWTGFSVLQRAASRAAAYDIGFTPSAPASQTKPKFVYLLNADDIDPASIPEDAFVVYQGHHGDHGAQFADVCLPAAAYTEKSTTWVNTEGRSQLGRTAVPPPGASREDWKIVRALSEVVGEPLPYDTAHDIRVRLYNISPSLVRYDEVERPSPEVFKLGLTTLSSSSAQSSAEPLKKPITDFYRTDPISRASVTMADCSKAFTKKEYVIGDVDSGAQASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM81</accession>
    <name>A0A1E3IM81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029618.1">
        <property type="nucleotide sequence ID" value="XM_019178462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM81"/>
    <dbReference type="GeneID" id="30195614"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="10881" checksum="C8E11EDF5BDE92DF" modified="2017-01-18" version="1">MEVEKRKKKRIEMGAGLYREGGSPAGVEHGTHLLATGRGSGGKDAKDTNDEKGKKSRQGKKIDMEKRRSLVDEPKGDVREAMVPQEMTPPTRTALQAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPW0</accession>
    <name>A0A1E3IPW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029650.1">
        <property type="nucleotide sequence ID" value="XM_019178494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPW0"/>
    <dbReference type="GeneID" id="30195647"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="70"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="441" mass="47518" checksum="F0B4538AE54EC0DB" modified="2017-01-18" version="1">MSDHESNPADSPTSPQPRRPGGLSEGPNARSKSVTVAPDGESTYGALNRHPAPRPVSIANDPSIPSESFRVGVSEDRNRRCRRTMEDAHSFVYDFAAVKGQGYFAVFDGHAGKHAAEWCGQNFHEYLLDALITEPDTPIPDIMNKTFHVVDQRLSHLAQTGRTSSGCTAVTAFLRVEEVDNTVHKGFTNPGLQARGLFEGRGEEELEALTSQQPSSRRSSMGGGTSGQAGGASSYGSGPNGMVRKMSSRKIRDFVKGLATRFGEGSAVEDDDNDDEAIITVDGTKVDAIEPQSSKGVRRVLYTANVGDARGVLSRGGKAVRLTYDHKGSDASEAKRITDAGGFVMNNRVNGVLAVTRSLGDASMKEFVVGSPYTTETTLDDTDEFLIVACDGLWDVCSDQEAVDIIQNVQDPQEASRRLLEHAMGNFSTDNLSVLVVKFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQF6</accession>
    <name>A0A1E3IQF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029942.1">
        <property type="nucleotide sequence ID" value="XM_019178223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQF6"/>
    <dbReference type="GeneID" id="30195369"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="195" mass="22255" checksum="DD3F730915BA2B19" modified="2017-01-18" version="1">MSVIRPFDPTDVLRFNNINQDPWTATYHNGYYATYALQWPDWCVSVEDAYEPSLKAYMIAKNEPPAPDPQHHGHLTALSITPSHRGLGLARVLMDILERLSAPGEMAGACDHGHGHDHGHEHAHEHHDHEGDCGHDHSHSHSHEQEEHHHEMIPINAGKDSVDAYFVDLFVRCNNKRATEMYEKMGYSVYRRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQL7</accession>
    <name>A0A1E3IQL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06145</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029930.1">
        <property type="nucleotide sequence ID" value="XM_019178211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQL7"/>
    <dbReference type="GeneID" id="30195357"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="680"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="760" mass="84037" checksum="86317752BD659291" modified="2017-01-18" version="1">MTVQEKVNLTTAVTGPCQANSGGVPRLGIPGLCFNDGPAGPRYTDYVTQWPSEFISAASFDRDLMWERAVRIGQEFRGKGVNVMLGPPLHRTKLGRRVLLLLIYLKGYLTDLAAFSPDTYLSSTLSYLTTRALQSTGLITSAKHYILYEQEPACDGPPDPNGGTTGCVDISSDIDEKTFREVYLPSFSEAVRAGTGSIMCSYNQINGTPACENDSALNRVLKEELNFEGFDFEAAHSTVESAIHGMDMELPTEHFYGKKLLKAVERGEVSSERLDDMARRILIPYLALQHNSSYPKVTYQKYNLQDQIEVDGHVFRNEHVDVKGDNHLWARKVAAESTVLLKNTGILPLPQGPKPSLKSLGIFGSDADYPSTLTGCGPDLFCTVNAKNGRRYWNGTVTIGGGSGAAYADYIVTPIEAISLRARRSHFRTDHILQDDPSHFLTVDTIAAQSDVCLVFVSVYLVEAWDRDDLRLDKGGEELIKRVEKGCKGEVVVVMHSGGQVLVEDWIDLPKIGAVLFAGYPGQETGNALVDILWGDVNPSAKLPFTMGRAASDWPPAGIIRKKAAPYPVSTFPERSAIDYKYFDTHNISPRFEFGFGLSYTSFEMAGLELRKEFREEEVGGRGKKMSEVSEGEGGLYEILYVARVNVTNTGRVPGAEVAQLASNPFQFCYHVLHAHGRQYMTFPPTEADQPPKHLRGYSKPYLLPGQTKTVEFPLKKKDLSVWDVEKHLWRMPEGNFVFRAGNSSRALPLVSLFTPNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISI4</accession>
    <name>A0A1E3ISI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05929</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030041.1">
        <property type="nucleotide sequence ID" value="XM_019178002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195141"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000028">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1981"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="2325"/>
            <end position="2357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN91415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2357" mass="267276" checksum="5A2D1F8E302406B0" modified="2017-01-18" version="1">MSTQTDVLDNIFQRLASRSEEVRSQAGDDLSEHVTAYTAEYPGHDGTKGVWTEVFHKTFEFTRSNNQLERLGAIMAIAQLLSLTKDDTPDRAQQKVLRLYEYLRPLTTCGDSTVMLPAASVVEDMVRQSPTLHTDTFLGKEIGQALVMIDDTRNEISRFSGTLLLYSFARSAPAVFYQYIPKILDKIWTPLRDYRSVVRERASMLLSISLDTVKARGDRPSTDTYRKIYEEARVGLLKASSTDVILGSLLAFNAMLQNQHISMAEYYRSICELTFKYRDSKEVAIRKAVIALIPSMATYDTEDFEAHYLSKSMNYLLGALQRQADRDIAYVALGHMTLHLGSRVKPFIEELMKTIREHLRMRGKKNAPYEAPIFQCLAMCATSVGPMLTRQMHEVLDLMLPWGLSEPLCNVLDSFASHIPPLLRTIQERLLDMLSMILTGQPYRPLGAPAPRGGRDVNLLQTSAGGQSTDTIKLALHLLGAFDFSGHTLNEFVRDAALPYLEHDSLDVRREAIQASTQLFINDPICHQTSSHSVEIVSDVLEKLLTVAITDPNSSIRRTVLDSLDEKFDRHLAQADDIRCLFIALNDEVFQNRERAIAIIGRLAHHNPAYVMPHLRKSLINIVTELEYSTNARQKEESAKLLCLLIAAAAGLVKSYAPTILSVLLRTASNPESSVTVQAECLKCIGELARVAGEELVPSVKQILVLVIDMLNDQSSSAKRDTALKTLGQIASNAGEVIRPYADYPQLMGLLFRFLRSESNLDVRQETIRTIGMLGALDPFKHKTLLGDVGDPIDEGTTSRVNDIVLLNQHNSSVNDEFFQTVVIHSLVNVLHDPAYKDHYQAVEAIMMIFRTQGLRCVNFLPQIVPAFLNVIRIAHSSRTELYLKQLAQFISIVKQHIRNYLNEIFELIHEFWNPNSTLQITIISLVEAIAKAVEGEFKAYLPKLLQQILRSFDGDLSAKHLPELRLNTLLQILKAFYVFGESIEDYLHLVLPVIVRSFENPAAPDSLRIASLRTTGQLCRKVNFSDHASQIIHPLVRTLAHSSEELRQTAMETLSVLVLQFGPDYAIFIPMVNKALVENRITHSGYDALVTKLLNRERLPPDLGPVERYLNDTSAEPVAADQVPLKVNQQALKLAWDCSHLLTTTSRTEWISWIIGLGHEMMRESPSQAIRAARSLALSSVAFTKELFNVAFYSCWQELFESYQEDLWHNLDRAIKKEDVPGDVVNMILGATQFLEHDEKEVAIESRVLGSVAANYQALAVALHYKEQEFFIDPSKEVIEDLIDVNQKLQQSDAAWGTLEWAQTHMGMTTEVEWYEKLGRWEEALQVWNQRDSDPTTTFTEWEITEGKVTCLHAIGEWEQLSDFVQARWANRTAEERKLLSPLAAAASWSLKQWDLMDDYISAMKGDGADRAFFKAILAVHRNQIPQALRQIAKARERLDPELTTLTGDSYGRAYDTVVRIQMLAELEEIIAYKDHADEPVRQEMQRQTWKKRLDGCQRDVEVWQRILQVRSLVLKPNEDMDTWIEFADLCRTSDRLNLAEKTLASLVGFSYPSMEDTRGRAPPPIIFAYLKMIWAKNLQSGSREERFETLQHLREFTDQLTDDVGIGARDVNGSLMLPDQKAYGSYTKLLAQCHVELGQWQAQVRENQGSNDPTGILQDYSLATELDPEWYQAWHTWALANFQVITQLEVSQQGLSPGHFTTYIIPAVGGFLKSISLSPGNSLQDTLRLLTLWFTYGYSSGVTAAVMQGLPTVNVDVWLEVIPQIIARIQTPRQSIQQLIIQLLKDIGKAHPQALIYPLTVASKSNVSARRTVAQNITHKMREHSQKIVDQAELVSTELIRAAILWHEMWYDGLEEASKHYFGDHDIPGMLAVLEPLHDIVEAGPQTLRETSFIQSFGHDLRNAREHLKRYRMTSDNNEIHQAWELYYQVFQRLGKQLKLLNVVELQYVSPKLMAVRDLDIAVPGTYQSGKPVIGIKSVNPTFKVIASKQKPRQISMRGMDGKEYAYCLKGHEDLRQDERVMQLFGLVNTLLNTDQECAKRHLSIQRFSVTPLSPSAGVLGWVPHSDTVHVLIKQYRDQRKILVDIEHKLMQQMSDESYDFLPLLHKVEIFQYALDNTTGQDLYRILWLKSRNSDVWLERRTTYTRSLALNSMVGYILGLGDRHPSNLLLDQVTGKVVHIDFGDCFEIAQQRDKYPERVPFRLTRMLIHAMEVCGITGNFSRSCEVSMEVLRDNRESLMAVLEAFVYDPLIAWRLTATTRPGGASEVQDLDDAAAYGKQRKNKANETEILNDAEGTEVKNDKGLQVIERVRRKLTGRDFKPDVVLDVKTQVEKLVVEATKTENLCVAFLGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU69</accession>
    <name>A0A1E3IU69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030273.1">
        <property type="nucleotide sequence ID" value="XM_019177889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU69"/>
    <dbReference type="GeneID" id="30195024"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="727" mass="81296" checksum="17EEEA28125FDD55" modified="2017-01-18" version="1">MDTEEPPKRKLGKVERGRAACNECRRHKIRCLPHPEDPDHHFPCSRCERMNLGCEFTKHNRGRKRKRPTGAGTEAASPEAPEAEPSKSRPQPRPYDYQSSERTEVFSKSFGDPRFPFISSDPADAVPSKGYSSTRYESEHRNYGARQPMSLKHMIGEDYENELSSDEDEEDSRYADEDEENREDQETRRRAKAAINGGGYSAPDPVKAGVVSEEEAKALFRLFMAHHNNSMPMLDPAVHTHDYIRNASTLLYTAILCVTSRYLPSITSNEHEISPESARSVHQQILVSARDNLTWIFAEAIIDINAVRAMIVLALHKEPDDDKAGYYINRAVLMGKELNLGRIPPKEELDRMNEDQQRCLRSRQRVWLCLFFANSIFAMQFRQTMLILQNDHLVASAHHWLKRSMPETLLRDTQLVCSVELRRKYLHYRDLLLGTGPEGTAYRSALSLSILTRSMNEDWDVISKAWIRDIIDVGGTSSHVTKPRIWSSALCLNLNLLLVNQTLRLPPDDQIDYGTPSSIPAFHHCLNAATTVLMRFEALDRQQLTFASDTFLHFALYAATLLSSLCRGQHPYKFDSPEIEHCRRLITKAANALDSASHYTRDSPQLHSFYLRRLLQYLPPPPPVPTSGSQRSSSPRFTILPGMSSLPGMGEEGSQVGAIADLAAVAGTGVGVGMDMDMFMSDFAWMGDLGGGTDGNLALGLAGSLGGSLPQMQAAGAPLYGSSFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU80</accession>
    <name>A0A1E3IU80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030283.1">
        <property type="nucleotide sequence ID" value="XM_019177899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU80"/>
    <dbReference type="GeneID" id="30195034"/>
    <dbReference type="OrthoDB" id="2561964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14005" checksum="225D44270D3F39F8" modified="2017-01-18" version="1">MLIFLISYVGYSDTYLDVWPQWVQSKFYVCGLMASLNSRYSLRRAVVGSESQRATQQPTVVHVLTETHVQKSESDPSSKEGCKPFLARLATDNKTAPRNYPQANPFTSPGDPPSSRYRFRCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVQ1</accession>
    <name>A0A1E3IVQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030320.1">
        <property type="nucleotide sequence ID" value="XM_019177569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVQ1"/>
    <dbReference type="GeneID" id="30194700"/>
    <dbReference type="OrthoDB" id="2593121at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="35838" checksum="7170121259F1273A" modified="2017-01-18" version="1">MSAPSPMLPPQQVKRPRQYNNPHSATNTPGPGVPLAGNGAAGGPLGPRTKRRKPEPIAAEVNKEKEIEGDIKTKIDFHDLPVETLYKYLELHDLLPSWDPSPWSEEPCMPPNLLYSIPPPPPSAPPTATAFLGASQSQQGLGPSPPPEETAAPIANADEDVKPPPPAADAAVPEQQPQPNGGENGVHVESQQQAEGGEKNGVQENGNGASGEEAQPDVSEPIVTDRPEEERGSRSPSPLPVEAPTTRSKTLPTRKPLTPPPPSPPQFTRGVVTLSDVLATRHELAEKANAHWARGLGGGQNKESETIVQFLYKMKVGPGRLLRVYNPTTSAQPPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVW9</accession>
    <name>A0A1E3IVW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="13" type="ORF">L198_05533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030366.1">
        <property type="nucleotide sequence ID" value="XM_019177615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVW9"/>
    <dbReference type="GeneID" id="30194746"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="118"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="359"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="519" mass="56418" checksum="D814929C6F819582" modified="2017-01-18" version="1">MAEQNTELTNLELEAGSEWRFELEGDENMAVRTLSQGSVLINSEEINPTTWYPIHRYTKAAIYAPSPARLQVANMPASQYTSSPTNQPQLINIHLALERERILAKRGQGSAPRVMVIGQANAGKTTVVKNLVNMALGSGLGWTPGVVGLDPASPPNLIPGSISLSTPSHTLPTHHIAHPLGAPSTSTAGNTLSGNVETLAWWLGTNEPTSKNLEVWKLLVRNLADAWEKRCQQDKNAAVSGLFVDTSSAFTVPSLSKKKDDHTPPYSLVTDAVQALDIDTILIIGNEKLQIGISRLPLLQARGTTVIRLPKSDGAVDLDDAYRSLAHSFIVRTYFYGEPPLPPQISSLVGKMVGLDSELTPYSFQIPWYRLSVMRVGEENTAPSSALPLGSSKVVSPTRLVKVDPSGPGHVVRLLNTVLALVQVKKEDWLNPEEMKEEKEEHDGEGAEGTEGEVKEEEQEDEDDEVPYKEEIGTREVLGFIVITAIDTVKKKYTVLSPSPGKLPSTVAIAGHIEWVDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0G3</accession>
    <name>A0A1E3J0G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030901.1">
        <property type="nucleotide sequence ID" value="XM_019177320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0G3"/>
    <dbReference type="GeneID" id="30194442"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="196" mass="21661" checksum="189799B64D89F0CB" modified="2017-01-18" version="1">MTYPLPDTQGIIDDDDWLEPPTQGGAKDPLVDKEYTRISTVYSDAGYREGITDGKLVTLQEGFDQAFAQAVPLSRGVGSLRGRAAALLAFATSLSPSAPENLVEDLRVLIRDLSSVRRDAVLPEDEERKQHEEEEHGEGQEAFELDVNDQRDMEGLEKSLEMMGGGGGVRKDEKVGEEGVERLEARLRELEGRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1E4</accession>
    <name>A0A1E3J1E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030989.1">
        <property type="nucleotide sequence ID" value="XM_019176957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1E4"/>
    <dbReference type="GeneID" id="30194064"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="515"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="638" mass="72693" checksum="59E9588BA0EB24B9" modified="2017-01-18" version="1">MSHYKVPPSRALSRNTSAQQFWQQSTTSLKASHSASADLASLRSPPTNGARKGAHPYDSEEEVKRLQKEIENIKRSHGEDLEKERETSRCLRERVGKLEGKVKRRDEEVVKYQEKLKDKERSTKAVEAEHDDERKAWARDKSDLREWLELERGRVAKLKDENELLRDENIRLKWNGATSPRALQPLQPNIPSSYNSLAPSTPRKSQSQSQPPASAPPTPLNLRKAHQHLESQHKALKAAYDEVRGKLDESTRHFRAYVKTQKEREEKRRARKEERKIRRSQGEVKPVLDRVEIPQVAEKAESHLAEEAALEPQSEAKQQISISPTLAENTEYTAKQISPTTVRLSTQERITAQPFSTHSKSTARPRTPPEEAFDSAAVSDEGRNPFFSGLNANRSIDETPSRPPKTEKPTTLHKSLVSRNLKQTPAPVTPQAAGPSSVKSEVMGSKRKLADMEGLTPAEKADVRKRLAKLPASERRDIYKDYKKGGRYLEPDQLLAQASDEYEINPSANEGAKFAFHDVKRKKEDRKHMHGGDCECCKGYYTSVGAMPKFNQGPVWQDSNEPEDGQHAMREHLNKSSRHRDTWVRAPTPPGYWDIGFPDTQRVQEHNQKADQMTREKEERIRREAMYVLNLLKGCFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1K5</accession>
    <name>A0A1E3J1K5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030987.1">
        <property type="nucleotide sequence ID" value="XM_019176955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1K5"/>
    <dbReference type="GeneID" id="30194062"/>
    <dbReference type="OrthoDB" id="2585179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11741" checksum="AA621B663E32ADC1" modified="2017-01-18" version="1">MSAPNKPLQLDPSQIYLQISHSVSQPPPNPVTKTGHQLRYVGQVGELEGEGVWQVIRPDGQAVKRGEEDWTEGEKSVVEEVKKLQGVKGVKVMPEVKQRPKRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1L7</accession>
    <name>A0A1E3J1L7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031003.1">
        <property type="nucleotide sequence ID" value="XM_019176971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1L7"/>
    <dbReference type="GeneID" id="30194080"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16730" checksum="396893A41784AD81" modified="2017-01-18" version="1">MLRCTPVLNTIPRTAPVQGYKHFLTPLRKLVVDYDAEAPSQDGVRSWITKPLIELARQNPDVEVVVRRVKRGKSAVLRGHYVNGRDKVICVNRLDVNQVNKKVDILLNSSGAKVKHLKNTTLEAAPATESARGIWSALHDQARDGKGYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Y9</accession>
    <name>A0A1E3J1Y9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Specific RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031127.1">
        <property type="nucleotide sequence ID" value="XM_019177095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Y9"/>
    <dbReference type="GeneID" id="30194209"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="818" mass="90737" checksum="C7C14CBD44663D89" modified="2017-01-18" version="1">MVMVIQASTLHLARNLHVNPPLHASDPSNIVVADMRNESDALQILALASGQAANEEERRETSMRQNGQRPSITTVPGGSSPSNGPGQPSSENVQGDTSGLKDFALVKMNIVTEQQAFALSEAYFRCHHHFFPIIPSAIIPRTYDQLSVFSKAEKYLLAAFIIIASRVDNTPEMRDIHDRSWTVMRKWISRIQSLGEPPTIGLVESLLLLAEFLPRTPRDSSPTATPESRDEDPFDSGVVEEPHGVENRQAWQIIGLAVRSAYEMGLDKLGLQLIAETERTLELERAKLAWVYCYLFDRHISIRLGKGFWTRGGSVCFQGYSSSAQTGPAAAIVNFPFLREIKSPDPAGNTPQEDLGSLVQAYLELTMMMSNAHDVLHPNAARTRSLVVYGEYFKYIDEMARSLDGFKILWRRKKWTLFPLTDTVWVMYYYIQLYICAFSFQAHVERATMRGEEEYKILEQRHKEQGHPSKLARPALSLFPRGAAQSPDARYIFQMCDAAREMLHICVDNMYPGGALPYLPSRFLLWFTYGAIVLLKAIYSGAMLMADHKRTLDLIDRLCACFAHCSTDEEYPAVRYGKQLEALRKKLAGLSSGNNTVPQSPNGSQIVQLPAQSRPNDVSGPRTSPCPPTRDQKLSSHPETAEDQDHQNRSNTQASWPQNQSQQSTASWQMPIAQQYAQPVTFPYPSAPSQYAPVPQTAPYVAPPHQQPFMEFGVAQSSDGYNLHMSGVDQVGGQIQGSVQGQGQNVNGLSNNLGFATLEDWFGFGAAETAPHPGQSQGQDGQRGAVEEGMGMAGMGLDLQDFWMNVGPGEAQGGFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2U3</accession>
    <name>A0A1E3J2U3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030812.1">
        <property type="nucleotide sequence ID" value="XM_019177231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2U3"/>
    <dbReference type="GeneID" id="30194350"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="226"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="416" mass="43919" checksum="F2D9EA2A0F436152" modified="2017-01-18" version="1">MPTALPLESHNPPNPKAFKPKDNHGFILHGALDTSFEQQPVPEIGPNDVLVEIKKTGICGSDVHFYNTGSMGACKLDGSMCLGHESSGIVVQLGANIAEQASRSSDIAASRGIAEESNKGPIAGRPLRLGDKVALEPGVTCRMCVDCKSGQYQICEHMLFAAYPPSKGGTLQRYYALPADLVYPLPESVALGYGAMMEPLSVATHAVANVGGVRSGYNVLITGAGPVGLLAMAVAKGMGANTIVAVDINEERLQFAKEYAATHTYIPVKPNAEEKPLAYSERAAAHLLKTCGIPNRGPGSIDLVVDATGAPSCVALGLQTVRPGGTYVQVGFGPPDVPVPMFRITTNEINIKGAWRYGSGDYPLAIDLVARGLVDLKPLLTHTFKFEEALEAFEITKNGKDKNGKGVIKCVIDGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J365</accession>
    <name>A0A1E3J365_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031278.1">
        <property type="nucleotide sequence ID" value="XM_019176803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J365"/>
    <dbReference type="GeneID" id="30193903"/>
    <dbReference type="OrthoDB" id="2572456at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="780" mass="84791" checksum="6934B5C69C93AED7" modified="2017-01-18" version="1">MSLFHLQLPPPAGLHAPDPSVVRPSLAGALAVSSLPGNSNGRGKRSLNARYDQLLSQVKAKGRSILSPKTRDAKPMLKKLPSRSRGGLFSHSVSALPVSAPTKQSVSRSTINQLAYHLGQRSAASTADWDREAPSFHPDPYPYQTSPRRDGYLTDAIPTDVDVYGDYPMDEDGGRYIASSIQNRSPSPLSQPNYTYHPAPPQLTPTPIHLHHPTPPQVNPQQNRQPMTLAQHRVRFRPAQENQLYSPSPATFLQWQMSTPKGADGSFASRDASMVSDLAGVGGRYAGYVLEHERWEEPSSFNWAPAPRQMDVSDVATAPPLWQQPLSPRMEAGPPPQKETHDYQLSSSPLFKHNQHSQTQNLSSDAYVLHSPTPQRILRLPTNLGPTRRPTPAPPQPSLLLSESIPPQLMQAHQSLLPAHIKSSSAKAKKARKERSYKVKGREVVRLLEEMAENESDGEENESTGADLWTTSQRDSRPPLVLPAITYEPSPSRTLVNLPISQHSSSATKVPSSGINGSSFDLSSDAARPSPTHIADPGPKAEPHLINDLLKRKEAPSPSSSPVAKAGKKMKGMSVREKIRGRAPTPGPTPLVVSQTEDEDIGLDLDLDASECGSQLSSATNIKNVRADIPFSNPPIFALSQLPVLPLPRPLPDYTPARKSLQPRRKTTGKRVQRIESESVTSEELESIRSFSEPPGGGKVMVYGSDDGRGIDGKGDQVIDSDGTAVESDVVATLQAGHGKDMTRQGSNADSEMYGKGKGWVDEGFFDANGGELGFRIWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J387</accession>
    <name>A0A1E3J387_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031294.1">
        <property type="nucleotide sequence ID" value="XM_019176819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J387"/>
    <dbReference type="GeneID" id="30193923"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="186" mass="19860" checksum="0B956648AFED31A3" modified="2017-01-18" version="1">MSAIEKGTTSAPRVIAQLVITGGKAFGKATFAAMQQAGKNFTHKPEGMADSAPRSADGKKNALTSQLQMSLDEARLILNVKKDDPLDVIQKHYDVIFKANSPPPPPTAAETKPGAKPSPPPRATGKSPKSKAPTHSFYLQSKVFRALERIKAEKEAEVTKSRPEGEATAEAGAEQPKGEQKEGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J395</accession>
    <name>A0A1E3J395_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031303.1">
        <property type="nucleotide sequence ID" value="XM_019176828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J395"/>
    <dbReference type="GeneID" id="30193932"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130105" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="743"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="826" mass="88849" checksum="6E10A7FF0D875BA4" modified="2017-01-18" version="1">MLKSPLLLLLLGTGVPAAIASPFILGARDNTTTTESSTASSTAAESTATIPSPDSSQNISSYHTSNITYISPQIPAPINATHANPSSNWTAAHEKARSYLSSWTLEEKVSLSTGVGWEQGRCVGNIGAVESQGFGGLCLQDSPLGVARTDYISAFPAGINVAATFDKDLIYARGYAMGQEFKGKGVNVALGPMTNLGRVAAAGRGWEGFGGDPYLSGWATDATIRGLQDAGVQACVKHYIGNEQDRNRTTSSSNIDDRTLREIYTHPFLRAVQADVASVMCSYNLVNGSWACENPKTLNGVLKTDFGFQGYVMSDWQAQHTGVLSAETGLDMSMPGDIGFGSLSSFWGRNLTEAVNNGTVSEARIDDMAQRIMAAYFLLGQDEDYPEVSFDSFRLTESNNSHVDVRGDHHKLIRHIGASSAILLKNENNALPLTNPRSIALIGSDLAPPTNGPNGFTFRAGIDGHTAMGWGSGSVNFPYLVDPLSAISQRAREGGAIINSYLDDWNTQNASYWASGAEVAIVGVHSDSGEAFVVDGNEGDRNNLTLWTNGDELVKAVASANNNTIVIVNTPGALIIEEWIDHPNVTAVLWAGLPGQESGNALVDVLWGDYNPSARLPYTIAKDRADYSADIVYTNSEYPVQPQIDYTEGLNIDYRHFLSEGIEPRFAFGYGLSYTSFVLSNLIVDEVEGAGDLAKRYVSDNPQVDESTEGEVVVGKFVVESLHKPRWTVSIDVANTGDVNGCEIPQLYLVYPESAGEPPKVLRDFARINLDPGATSTVSWNLSQYDVSIWDVESQEWVVPEGEFGVEVGKYVADADAQTGSFTPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3G5</accession>
    <name>A0A1E3J3G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1</fullName>
            <ecNumber evidence="5">3.1.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Metazoan SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Penta-phosphate guanosine-3'-pyrophosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ppGpp hydrolyzing enzyme involved in starvation response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>guanosine 3',5'-bis(diphosphate) + H2O = GDP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:77828"/>
            <dbReference type="EC" id="3.1.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MESH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.7.2" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031185.1">
        <property type="nucleotide sequence ID" value="XM_019176710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3G5"/>
    <dbReference type="GeneID" id="30193806"/>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000012">
        <property type="entry name" value="HD domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="12">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN95205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="294" mass="32447" checksum="CD2B31B14BCEA2E8" modified="2017-01-18" version="1">MSPIRLNTPTPTHICPNNSLQVIDISTSPAHSDIGLRTPPAHSFTPTPPLSRRSSRALLADEGGKSAMGGLLGEEGELGVLLRTVDFAARKHSCQRRKDVDQTPYINHPIAVANYLATTGITDVRVLQAAILHDTVEDTHTSIEEIAQQFGSDVARIVEECTDNIDLSGLERKAEQLRSAPGKSNEAKQVKLADKIHNLESIRRSPPVGWGVKRVQAYFIWAKKVTDICAPAHPPLAARLDRLYSTAYTRVNGVYHPCHPETCGPLTEEEKERVDRRLRDLKDGDTICPEPLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4F9</accession>
    <name>A0A1E3J4F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF866 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031397.1">
        <property type="nucleotide sequence ID" value="XM_019176469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4F9"/>
    <dbReference type="GeneID" id="30193563"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130123" description="DUF866 domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22680" checksum="713EC2CAC9E0DC17" modified="2017-01-18" version="1">MVVSTRLILCWIELTTVSFPQKLRVSISIELEGVTNVRPADDDYEYFFTVMCSSCREVHPKTVGLNRNASALSTINTTQGDEHEISGSKGSANFVWRCTNCKKEHSASFLPSAPKSKSTAPLPYSNSSQFSSFVTLDCRGLEFTEFHLRRGKWVCEGEDSGKAFEIDWDELAQEGEERWDDYDEDKGEAVGVSELKSKVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4L4</accession>
    <name>A0A1E3J4L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynactin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04401</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031448.1">
        <property type="nucleotide sequence ID" value="XM_019176520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193614"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1175"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="314"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN95783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1285" mass="141111" checksum="EEB2519A8C289B3A" modified="2017-01-18" version="1">MTTPEVPVGAKVQVSVGIGHVRWTGTNPGFAVGKWVGVELLEPAGKNDGTVKGERYFDCPPLYGVFVRPSQVKILETPKTAVSPSCPRPSSARPPATPTTSRLASGQSSRASSPQKPLTSRAPPTPGQSSRVTSGSSATGVPQSPAPAPPPARRVSSTSSRPGQGNIFKRPPSVLDRAPTPLTTAEEEEDEPVRGVISPPPQRVISPTRRVISPVPSLSHQTGTRSISATLAPPPELPSPEAHPAANPTPRSPSPDKGAIHESAMKRELEELRIRVRILETRKHEDGEKIKDLEGRVGEADSLKTARVRLQAKFQEIQSALLAAQRSAKDLQAENGVLENRAAEAVDQLEMAALDREVAEEKAEAADSEVVKLGERVEELEMEVAILKEENAEYERPVSGVEGERTSLAFVQLEKHNERLKDALIRLRDMSSEAEKDHKTKMAELERELTSQEELITNLELAEAKLSNAESQIEDLKLQLDDALGAEDMLEQLTDRNLQLSERLEEMRATIEDLEALKDLNDELEEGHVETEKQLNEDIEALEIAFREEKRRAAELEEVALDMESTIGQFRELVQSLQGDLENVRLQQMNQESDTATVTKDSQALMNLNLKLQSTAAKAQSKTIDLELKKLEATQLFEHLRIVQAYLPEAYHETEEDSASMFLFFNRVGAKVDMLVNVVSQVHGLPASLHSASSEALVGICELKGKLRYFSTLNKRFSSVMKRGSTDDWSAYGKFLTEITGVEARIDSWVAALKNDEFSECDCARDLGSLVAQFDHLAETAFHRPQLDVGEQQLGLAHVFDCDLDNFAAAVGFARHAITSLAAEEDIEIDVGESSLEESVYDPVQRILDLVRSVQVPSAKLVHQIEEIAQASSAFMPEITLILSDLTASVSNAVDLAVQLAQRIGQHTALLRSTKQPLKLSDIEGFLADVTAQSASAGVQAHPWEVIGAFVAKLGEELGAAVPKVKEAVKEGRVMVYDAPAPWIARVAAIKEAASHNAETEKQVLMLTEEVKDMLREIKIRDQTLQEAGVKVETLERRLETSRKQADDIVDLENDVAKAKKQEKVYADAVEQLQQEVNALENQNAELRKGQGGDRQVNANQGIPSFGEPIIVGSGAGLESSQLAEQVANLKSAVRFLRQENALLKSKELYKEIHSLPTLGFRSEPDVPELVSSLYKETPATPGSESESSLPSTPTHSPLRSLPPTKHALEMESRILLYQIAKFQASPKIVDISQLGGEKVGWKSRKNAPEVQVGEWKKKERRLERRLEGLVGRARSLGERSNLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5F1</accession>
    <name>A0A1E3J5F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mog1p/PsbP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031316.1">
        <property type="nucleotide sequence ID" value="XM_019176841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5F1"/>
    <dbReference type="GeneID" id="30193945"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22152" checksum="BDD2050ECAE3114E" modified="2017-01-18" version="1">MSAPLAPRPLFGGAIALALPQDSIDASDLRQIPDNQEVFLFPHSDTALVLEVLELVEEGGAKDDLWEAAKFHFGSIAHDNASLSSTILTPPPSSPIPSTPSTSTPSQIKATTLAGTQQIHKFSHDPTGAPREGHEADVPDQVWIGLALWRVWIEGAAGRKKADVVLSVNVNLSAEGGEGAKEQHLVEGWFAQAVDSFKVEDFGLFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6G6</accession>
    <name>A0A1E3J6G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031678.1">
        <property type="nucleotide sequence ID" value="XM_019176268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6G6"/>
    <dbReference type="GeneID" id="30193359"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27434" checksum="0242D338D73EE5CA" modified="2017-01-18" version="1">MQWPSSQHNIPVRKERLPDPGSYRHEQSTLDNLGAAGKPQHNIKNLNRPSSRYKKRRETKQASPIADRTLTRQLAGPLNLHPESLLSLAEVNKKAISPINDNHGVLPEQAGQQQPMIDFMAQTSTVDPQTGITLNVGIPCIVVHHGGPRIKACIQYIGNVEGLVGPRVGVISKDFIGTSVPALSTGTYLGRHYFDVPPDDGKDFASGRTCAELDLQDSPERINHKAPATARYCRAFFVRPCDILVVLGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6I5</accession>
    <name>A0A1E3J6I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome assembly protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031698.1">
        <property type="nucleotide sequence ID" value="XM_019176288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6I5"/>
    <dbReference type="GeneID" id="30193379"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="520" mass="56741" checksum="7632EF35AA9E9322" modified="2017-01-18" version="1">MATQFPPPKRQRSAYAQSKDPKIEVVQKDIPSVVVQFKSAEDGSSLGPAINLPADTARDALQMLVNKLRGEDEDPLPYAFHLVPKVPSTSTAPTSARVQINNSILADALESKGSTFSSEDIFELWCEPQAVFRVRSVGRCTATLTGHASPILCCAHSPTGRYAATGSGDATGRIWDMETETPKWTLSGHKGWVLVVEWDSREKIVATGGHDGQVRLWEAATGQAYGAPLLGHTKWITALAFEPLHLVSPKAAGPRLASASKDGTVRIWNTGTRKLEFVLTGHAASVNCVRWGGENVIYTGSSDRTVKVWSGVDGKLIRTLNEHAHWVNTMALSTDFVLRTGPFDHTSKKPQSDDEARARALERYKDVTSTHPETLITGSDDHTLYLWPDQASSSFASTATPKKPVARLTGHQKQVNHVAFSPDGRMIASAGFDNAVKLWEGRTGKFVASLRGHVAAVYRVAWSADSRMLVSASKDTTLKLWNLKTYKIRIDLPGHTDEVYCVDFVADKVVSGGRDKTVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J921</accession>
    <name>A0A1E3J921_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031832.1">
        <property type="nucleotide sequence ID" value="XM_019176422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J921"/>
    <dbReference type="GeneID" id="30193515"/>
    <dbReference type="OrthoDB" id="10480119at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN96586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="175" mass="19778" checksum="0B34B4F63B1409AC" modified="2017-01-18" version="1">MSNHRQHLIASADNGTQPVNAPIGSVIDHLPPKLEELVLDGIHVPEELTMNDIAQIQTVTLGWDGVARPNRLRVISLNDCRLYLGELLKLQYHWLLARIHALDKLSLEERRGYDMPIISVGNPSAFKKVAWWQRYYDNAKLDSASHRVLAAQAKQVMALSEVDEEGLTKEVVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J950</accession>
    <name>A0A1E3J950_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031979.1">
        <property type="nucleotide sequence ID" value="XM_019176066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J950"/>
    <dbReference type="GeneID" id="30193154"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="496" mass="53719" checksum="2BC0A6A7BDD0E1C1" modified="2017-01-18" version="1">MANLELESDSYDVVVIGTGVSHSIAAAALAKAGKNVLHLDPNDYYGGDQASLTLDELSEWIKRQPEAGQAEGVVAYSNASATALTPALEADRRRYSLSLFPALIPSRGSLIETLISSDVGKYVSFKLLDSVSIWNQEQGAPQRVPGSKEDVFKDRSVTLLDKRKLMKFLLFAAGEFEESEILRGKEDQPLLQLLQDSFGLSPQLAASITYAIAHCESPDDKSLPSLIRTRRYLRSIGRYGPSSFLVGQYGGAGEVAQSYCRGCAVFGGTYVLGSPSIPTSCVVTETSATISIPCHPRPVTANHIIASTDYLPPAALTKDETLSSHATVFAHCIAITSSLPDVLRRPRATESQEVDQDENDDTSLLVFPPEGDNPLVRCLINGEGTGSCPAGQYIIYLCASSDTSSDPSALLRPCLHRLSERPTFEAYYTCSRKSAQETASTPHAVVLRPYPGKELLTEGLDWEAQEGERAFYEVMGRDGKPFFESEEADVGDGQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBK4</accession>
    <name>A0A1E3JBK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032115.1">
        <property type="nucleotide sequence ID" value="XM_019175625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBK4"/>
    <dbReference type="GeneID" id="30192708"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="78906" checksum="1608AFA90003E8DF" modified="2017-01-18" version="1">MSPSAPTPATPSNYALSAYGNYPSTSASASAPTPSGSHSGSTTTPDDGRVGHGQGDGQDDTEPGRKRRKVTRSRLGCFTCRKRRKLCDMGKPVCQACTRLKMECVYPPDGGARPPEELRRKSDPANPTKAKGHTPYSQSANVYHPHLSPKQLYDPGRHVAESMARSTPASNTMDDFVTIFGEIGDTRGGMTMGGPTGGIGYSGQMLPPPDPGLADWFSGGSSLDEATLQLWAADCLAVPTTQTFNAFESLNNLLQPTPPSHNQQDPTATSSNNQADAAETGCGAALHSHPGSRRPSPSRSSDRDTPTTTSQTALLNYFHESLARLVSCTGDTAPSAFEAFTKLANMTAGVGPASQGLHLSILAWAARHMVNRGLVKYEAVSEKFSGQATRLVDRRMSELFDSKGVEISGGVEEEDRDREYMTLLAAAVMLMQFKICRGDVWAFNTVVKHLTRLVPYVFRTEVDIAPDSMYLQFFENVLYHDVLSSFILNQAPMVPEALIKHYHPSSLETLHTLTGASLPLFSTMHRIASLVRQRRAKRGKRAGWSDEELMDVLTPARELERVLEDEKKRLDALVLAKPHVKPHRYLHEAFRTACLLQLHYHVLNEAPASLPIRLLVRQSLSLLEAMSDQNLPGLCSAHWVIFTTALCCVPGGQEAGEMDDRERVDRIYDDILQDFGFLNVERSRKIVHEVWSRNVGGAAHFDWLDLLEEYDWEIFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCF4</accession>
    <name>A0A1E3JCF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032227.1">
        <property type="nucleotide sequence ID" value="XM_019175737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCF4"/>
    <dbReference type="GeneID" id="30192822"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124593" checksum="B92B7D475B072ECF" modified="2017-01-18" version="1">MEDPASSPSSSTFQLDSPSASTLLRTADTLEGLAKQLENLKDDSDASGGDGEVLRCCCGAAVGDEGSECRMMKDKQRTEDKLKMSGELGTALLQRYEVLEKKNRKEGERHQQLIEVKRTALAASVKRVHNLEKANTTHMQKYAEMSRKMEVVEKRYAEAMHTQTLTQQSLTHVRSELTNLRDTNARQTVALASRGGVEERLLDAEKRFEEARDLAAEETRKLRDERRKVQRAESRIAELETQLRMATKEADAVREARAHDAQDLLANAKKRLETLHAELSEVNNGESPEHLPEHQRILEELVANNTLLKHDAAELSHSLVESRDEVRTLRDEIESLRASIGSSRLASPIDQYPRLAHELSPRFSHSRTESTPIPGWNQSRLSPWEHSRKLSTGIAGLGMGPIGEAEGSVASGDVRSTPVSPVVESPQQETRPSPGGGIGYMVNGVLKHRPASARFSGDSRVMRNYASRTIGSIDETISQDEPQSPGSDYFRAADISRKRRSLRLSRQFTPSPNDISDYSPNASTMVDQSTSVDLPSPVSESAVPERKFESPKQASRRTLLLLTKSRGVQTDPIPEEKVTSERGRTQKITTASSSRDTSATGGSSAFATPNPEDGPASSLLVVVEHMSRILAKLRAADVPTLNKRLKKANLSGDVMHLSQTTLRSLQQEISEVRHHFRGIHNFGMIDPRDFNLLLRLMKDVFNDLVELQAVVNDVTITPAVAKKLQRAAYRAEEDEAAKASNVSSGLGWIAAPITKFFVTPADAEGDAANDTSPGLAAVAGLDRGKSMTMPRKAVPKQQAMASATATHVSVNFGGTGMVRKIAPAVGLSGPGGEALSSPVPPVDQRAVSGPATLGRSNGGLAPPQTIRTLRSVKSKANRNDLLGIFAGAAPRSSTPEPWTVVKPPDAGSRAARGRQYEEKTVRPFAMDRKKLSSAVDAVIDQSAIEEDDDVAIAGSYEPPLLERQLRPRGLSDSSIRSTTVSLARDFTHHIPAAAPAPNRAAAYGTTPSTSGSVFQTLSKKFYSFRAPETLSPEPEDSSQLGSTPPQPPLITKQIPSPARPIPRSPSRASSVSTTTSSTRGDRSSRQTGASPVTASSSQTRFFGYIANSLAPGSEALEQGMEGEQEFVGGNFRQGAMLGHARLDSGKQRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JE68</accession>
    <name>A0A1E3JE68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032258.1">
        <property type="nucleotide sequence ID" value="XM_019175768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JE68"/>
    <dbReference type="GeneID" id="30192853"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21643" checksum="00A8A468B4CC46B1" modified="2017-01-18" version="1">MGAFNIPIPQPSITPLATLLATLSNQTGLPVNQLKLVHKGAVLKDTSLTVSAYGITEGANLVLIGKGGDIPAPASSAPKQAAPVAKKPKQPETDSEPVLVDWIESLVSNLLDPLKPSIATFISYTSPHVTNRPAKIPAFEVLQKEHARLSELLLKALLELDGVNIQGGWDVARKERKEGVRSIQGELNRVDEAWGERKRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEE5</accession>
    <name>A0A1E3JEE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032143.1">
        <property type="nucleotide sequence ID" value="XM_019175653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEE5"/>
    <dbReference type="GeneID" id="30192737"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="294"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="647"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="74041" checksum="AB46B44CEB0B6F38" modified="2017-01-18" version="1">MSKQGQQEIQPDAPTIVSPSSPFATNPAPSPLADATAADGAPNNDAEAERSETIASDKTAKTSSEEERSQDGEEQLEEAREGSRHKQPLDTFKTPAPSRSSAATPSAPNAPAPNPALQAPPAQTPASSATPAPGGGSAAGMGVDLAEFDPYATPVPSSSESGQEKEKDASAGSKVKVEESQAMTPTSSSQGRARAGEAAAGKRPEESVSEVERGEEEEEEAEESKEPQFNFSEFLKDLKMKSADPVARYLKSFLSNFVKKPFTVNEQIKLIHDFLDFISEKMLLVEPWKSQSPAEFDNAMEAMEKLLVASQPITTDDLERDAVFQQRVRLFGWIREKHLDVPEGEAAVGFLGFAEQELLKISLIRNTYGPSSGSADAFIPILIFTLLRANPPNLISNIEYIQRFRRPSALSGEAAYYLSSLNGAVQFVETMDAGSLSGISQEEFEKKVEDAIGELPPSPSDAMGGDSLARGVRTPRRGEDDRKERERAAAGVSPFQTPAPGEEAARPLSMMTAQASLEGTKRWFTKTAGTTAGNLGNLVQEGVSRPLSAIGKILEGMSPAPGSEHRQGQRSEDGSDEESPRRGDRDVFGVRRFRERERAGTPDSPLRFLGVEDVDSRSTTPLSETLPDFSSLQLQASNAQSHSSEMTHRANVQTLGQMFPALDEDVVEAVLDGCGEDLGLAIDRLLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEM9</accession>
    <name>A0A1E3JEM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032223.1">
        <property type="nucleotide sequence ID" value="XM_019175733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEM9"/>
    <dbReference type="GeneID" id="30192818"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="390" mass="43205" checksum="A3170EE40C2DEBB5" modified="2017-01-18" version="1">MVTYIDIPSAPKRLAYILSKPGKRVATEIDPSFPTVYLCHPPWTNGYFYYPQLEDSSLNQHYNLLAVDLPGHGPSRIKEPLEGKISWKRMSLILYEAFQALDVKKAHLLGNDMAALAPMYMAIGHPEIAESLIMINPLGPPEPESDLMKLTCILSCQLQAELMESQNPDLLDILDTILVKFCTGQMSNWILRDICDGLADLARAKLLCGEYEAYHRVFMALLTSRFAAPSTEELSRMDFPTLIIENFVPGEEDDPDSGIDVWVDIVGKLNALSASRGKPSLAARHALVGESITKSNSTSRWTTMTHPGLLTPLLKDFIENTTSFSLFAQTESHLGRCQPREPEYPPDLGDILQGSSAASSSQGAIKTWADLVDEMQQGEGISEVYVEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JET8</accession>
    <name>A0A1E3JET8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032283.1">
        <property type="nucleotide sequence ID" value="XM_019175793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JET8"/>
    <dbReference type="GeneID" id="30192878"/>
    <dbReference type="OrthoDB" id="5277092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN98421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13106" checksum="EBF4C8E7C7339F6B" modified="2017-01-18" version="1">MGIFDWFSSNSSVVPVNNDIPKPRSDATVNAPPPEQYRTVAQFVSESPAGTYIFDSRKNDDKADTELCRLNPNGGRSCVKVAMHSAALFKSMQALGFYCALPAEPTRTHMECNHLPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEV2</accession>
    <name>A0A1E3JEV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032487.1">
        <property type="nucleotide sequence ID" value="XM_019175384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEV2"/>
    <dbReference type="GeneID" id="30192465"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="316"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="360" mass="36752" checksum="9EBED3D52E8EEB03" modified="2017-01-18" version="1">MVKITFKTVQNKVADLKQKIQESQTFPAENQKLIYSGKILNDSSSVESLKIKEKDFLVVMVSRPKAAPAAAAVPSTPAPAASAAPSTPAAPAPSSGPAPTAPAETPTPAASESAQPSGSAALGTSFLAGDQLQAATDGMVEMGFERDLVVRALRASFNNPDRAVEYLMSGNIPNLDPPAPAAPAAAPAAAPSAPSIPAAAAPSAPAAQPAGQPAAEAPAAGSADNLFAVMNRDRGAPAGAGAGAGGAPGGQLDAIRQMIQQNPALIQPLLQQITAENPELAQLIQQNPEALYQLLGGAGDGDDDDEMGEGPVMRVDLTQEEAAALEALGFDRQMVLQAYMLCDKNEELAANFLFDQTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEY3</accession>
    <name>A0A1E3JEY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-1,3-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032517.1">
        <property type="nucleotide sequence ID" value="XM_019175414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEY3"/>
    <dbReference type="GeneID" id="30192495"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN99440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="530" mass="60117" checksum="E28C1D655094D644" modified="2017-01-18" version="1">MKPAASLSLGRKLPSAGSLLLGILVGLLVASFLRGGETNVESWKGSKSLRTNPISASSRLQRSQITLPSNEQRLHILQLISTLSSHHTKECLRNPQPLYVEQVKERYEPLMGYKKSWSRGKGILGRLFGLGGGGKDAAQVRGGVGGKDKMKDIKRDLQTAQHQYFFAINLYNSFDVIPDIFSTLFRVAAILGYHNVFVSIYENGSNDQTKALLKIFDALAQTVGLRIIIRTSMRTRGLFNHRIEYLAEVRNAAMLPLHELRDKEGIVFDSVVFMNDILPCVDDLLELIWQSRRQNAGITCAADYMYHDDIGAPVFYDNWVARDINGTALENAPFEQIFHHTESNHRFQRHLPIQVQSCWNGIAVLDPAPFYEPPHARFRMANLAQGECSASECSLICNDYFNAGYGRIIMVPRVKLAYDQKVYDIIHPERRNLTAIRGYKRIGGLPDDPHTDPQDRSWYGPHDRLFTPEEDEELDFIPGPERVWCWGWDGAGDLDGPDVDPIWEQMQPRSYSQEAIEVKHFRNLPNYPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF06</accession>
    <name>A0A1E3JF06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SYM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032501.1">
        <property type="nucleotide sequence ID" value="XM_019175398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF06"/>
    <dbReference type="GeneID" id="30192479"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="188" mass="20936" checksum="98A677DD7911EBB3" modified="2017-01-18" version="1">MAALFGRYSAFLARRPVVGNMASSAVLFATGDVIAQQLIEKKGKDHDLTRTGRIVVWGGLCFAPVVHVWFKTLARLPIQSKVAGTAARVALDQFAFAPFALTSFFTAMTLMEGKNLEAAKLKWNESFVDTLKANWMLFIPFQAINMLIPLQYRLLAVNAVNIPWNTFLSIQNAKGKVEEEKVETLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFP7</accession>
    <name>A0A1E3JFP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032572.1">
        <property type="nucleotide sequence ID" value="XM_019175469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFP7"/>
    <dbReference type="GeneID" id="30192552"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="193"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="843"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="892"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1148" mass="122652" checksum="03BB0B7B30D709B8" modified="2017-01-18" version="1">MSDTEIKSSPVGSPVEERAAGKKRARIVDPDETDEEDYDNAPEESNGGKDQEEEEEEPSRKRSGDDDEDDEEDEDEEDEEDEGRGRPRKRPKKNSKFRFLDVEAEVDDEDEEEDEDNDFGDVAEFIDEAPDDAVARDDQQHRRLDRVFGRNEDEDVHDIVQRLKERHAGSGMARYNGDSDAVPQRLLMPGVNDPNLWKVIVKAGREHAICASIFRKVFAQQYSANPIDVISVFCRDSIPGMIFIEARQSAAVSAAVNGIVGIFMSRGVSLVPIEEMAPLLKMKKKDVNLTPGMWVRMKRGKHAGDLAQVVDVDQITSGVVGIKFIPRIDLTPKDKRKERIAAGKPGGVRPPSRLFAYDDVRKIYGRQSVRQGPQGSYQFENDEFIDGFCIKDVKIPTVATEDVNPSLEEISRFTGDDETTAKFDLSAIADANKNLSTSLLFPGDKIEVYEGEQTGLYGIVETVTPDVIAIKAEGGEVHGQIIEVPARSVRKRFDVGEHVKVLGGKHVEASGMVVEVKGDIITLMSDQGEQEIKVFSKDLRKAADTSNLTATQGLYDVHDMVMLDSTTAAVVTKVEGGLLRVIDQNGAPQSVSPEQVTLRRDNKRFAAATDSQGNEMKVGDNMKETEGELRQGEVINIFRSLFVFLYNREYTDNHGVFVARAGSLISVTPKSAVNDLGKINPALNQQLPYGGASLMPAPAVNANRNRLINTLVVVTKGTNKGLIGVIKDVQGETARVELKTSNKTLSIALVSLKRKDAKTGTTFPLESGGSFAAPGGFGAPRNNPYDVGPYGGQTAMHPSMGGATPGLMGGKTPGARFGQTPNPYAAGVGNGKTPNPYASAVSGGKTPAAAYAAGGKTPAWGANGGKTPAYGAANGGKTPAWGGAGGMGGKTPNPYAMGPGGGRTPAHSGYGASSSSRPYQPMPPPPNPYGAPTPAANGAPTPAVPSNTYTAPTPGAVSAPYTAPTPYGAPTPFAAPTPGAGLSAPTPAAGGPMHGAPTPFGAPTPYGAPAYGAGPSQPQSVMDYDWALDFRNIIVEIGQSSLRSSRNPLHYKRGAYDGRKFGYENVNGENCVCVQLDDPSVVEEIPAEYLRPSKPDGQGQVVVCIGGDFKGQQKVTQYENGGSWMMDTGGDLAPLVIDGNDLCRIWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIF7</accession>
    <name>A0A1E3JIF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032866.1">
        <property type="nucleotide sequence ID" value="XM_019175134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIF7"/>
    <dbReference type="GeneID" id="30192212"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="678" mass="74212" checksum="C705B142EF5E537B" modified="2017-01-18" version="1">MREQLHPPSPPPAKRARHDHHGIADLFPFQELFLRILSFLSPGELAAVQGVSKYWQMMSLDPQLWKRLYLARYPHPHQTHQDQDPGPSRDQGPMTPQSVRHIARLPSRAFPPPSPSRTSSATPSTNISLSGMPGPPDIKGKRKASSMEDVPEETFVRHEGMDWKMMLRLGTNWSNGNALSEATIPLPPSPSPSVTSASPLPSRLNQLSDPEPGHPRTQHLALFPSFIFTSSPESPLVHCYPASSSLSQSSVLGIIPPPPGWSNPSRPDCVTAICADQAVVLPEPTGSGEEQAFPAQLGVFYQSGGFVVLTIRLDSTPSAEKRTITWSRSVIRPAQTRPQSLRRRAQSYYPDRGDPIVYAAMHGKVLVVCTRGFSMSVYDLKEKDGDGPRCLRTMKSDVAFHPASLSLLPNSQNKSAQHDVTSKTEQWTASLTYTAPVYPSSWTATVQELHISLSSPTQSPVYPVTIDVERGCTYQVLSPSNDPDEWPRKVRPVPGVKGSATNIDSDGRWCVLSGQDNRVEVFSFAPGSRGGIEHRQTLLAHSSSVTALSLDAGRCVTGGRDGRVLVWELDDAVENAAGHGQGRLGRTVGYVEVRKGGRKSIWKGPSGPRGEEDREVLPHPQAISSAARSLFLPQPPLSRPQDNVEDRIEIKHLAFDEEKIVGVIRGAGEDAIRVWNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIV8</accession>
    <name>A0A1E3JIV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor, arginine/serine-rich 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032957.1">
        <property type="nucleotide sequence ID" value="XM_019175225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIV8"/>
    <dbReference type="GeneID" id="30192305"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="40524" checksum="5F505780562936E0" modified="2017-01-18" version="1">MGSRDRPKSRDRDSSDRHGHRTRSISPRREHGRGDKRRSGSREDEKSHRRDSHSRRDSDRRSSRRERRREATSSSEEETLDLKEMGVAEISESDDYLRYPEFKRWLRDDRGKYLDELPTESGQKYFRRFVRRWNDGALDKRYYKTSSSRYRTDGFGDHSSVHSREGTEGTAFPSVRPDHRVTSGRPERRDAVPVGPSLPSSLRPLGPSIPSAADRQFAQEASRDARTLERKAMYKDQARRADDEVPKSGGREGRIEERRAVNAENRLHREKDTTAGLEVDDKTLMGDSNSFTAALRRRDEAEARRREKKEYRDQDQRAAVSERLSERKTKEDATMEMFKQMAKQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY3</accession>
    <name>A0A1E3JIY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032975.1">
        <property type="nucleotide sequence ID" value="XM_019175243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY3"/>
    <dbReference type="GeneID" id="30192323"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="536"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="745" mass="80353" checksum="D4D721DD38FC0A6C" modified="2017-01-18" version="1">MALSNRQYTNDPEYVKEVVRNYINVKQSHGRQSWEISQKLELIERDFSQHGMSFVQARREMGLPPSRVIRVLGTNNSTSNNSLYRAQTTSGASTVSHRPSTASTSSRPAAPNHNRRTSAPVVQRPQERDAEAGEDAPPPPYASQDPDPEATRLLQVRLAAESVNNPAVTAAVATPHTPQNSTPAASSPAPSTPMSPPAQPIASTQNAESSQAQASQLPRPPSDPEMARIWEESQFEEAKRMSLQAQSEQEQLDEAMRLSVAEAESRAYNGSSEAGPSHLPVVTEYEPYQPPVQHNGGYETGLNSDLEGLNIGGSEGSYAPPAGAPAGNNRFSSIMDHDDNPSGFSQQPLTPSKTGPTMQSKNPFLAPSEQETHEAGSPQSSPYGYTQQQPEEPAGSSHTTYTPPAYAPPPGAPPPHLVILSSTPSRQVSNQNIYQSPIQNSPSSRPLPPTPDVAPPCYPSPRTAAAAPPSEHPSLTSSLYGARATDFDAAGSSLSGGVPRPGGISTGAGQTPDRRRTSYVPPRNGEDPLEMLREFDTVFLVDDSSSMAGPLWREARAAIMEVAEIASRYDEDGIDIHFLNSKRVGRELKGRDDVEELFEGLKPRGVTPTGMRLEAILRDYMTRLERASTLSPSIGSSSEEHVKPLNVVVVTDGAPTDDPESVIVAVARRLDRGEYPLSQVGIQFLQIGDDVGATMALQQLDDELSETHQIRDIVDTVPDSGQEMTAQFIIKTLLGGINRRLDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ14</accession>
    <name>A0A1E3JJ14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033037.1">
        <property type="nucleotide sequence ID" value="XM_019175304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ14"/>
    <dbReference type="GeneID" id="30192385"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="11">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="363"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="12">
        <location>
            <begin position="596"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125784" checksum="52924CC24DB1ACAE" modified="2017-01-18" version="1">MSSTHLTSIPQAVRVAASIDNSVDPDLKQQAIDYLTKVKHLSEETWQLYLQGAGAERPSSLGRDGKEKQETNMRIFCQQVVDTALTQKPNVLNAESMRAMYQAVVEFVGLEYIEGPCEGGQAFLRNKLAFTIAQLFLHAYPHIPSYLHPFYALLAPPTSSPPNFHPQLLTIRILLEVAQEIHDITLKEARVMTKERQERDGVIRDMIRSSGDDKVAVEGMLRLVDTGLERIHKGESIDKWGETVDSTLKALSAWIPWIDLGVSLNPTTLSFYHRILRQPIFSFRTSAASIYRTLVAKGIQDPQGRLQVLRVLDPVSLIDSLESETANNQDEDVIAFRASLGAVLSAYGVSLVALFDNNEYPEQLRNEAESLMGDALPLLLRFLSDRQYEIPLSVSPFVSDLLRIYKRMFRPAAPATKPGQPPSPPLPVPELSPERRQFLAAMLDILIRQLAWPEDMEWEAPGNEDDTDEEVAAFKHFRGSCRSFIESIAQIDKSLHTEVVARIVASTLDAYTTGGAGVVAWQQAELALHLVYTFGEVSKNATRAAFFDLPPEVATKAARNKFRIKADSQASGRTTPSSASDAADPSDKFEYENYPLSALGQLLTRSMGSGISSYPHPSVTLQYFEIIVRYVEFWKPKADVLPSLFEAILDARGVHNSDEGVRRRCFYLFSKLCRECRNDTIEPMVAPILDNIRDLMVITAELPPIDGPEDDPLLKATTGKTYVADQLYLFEASGNLIFATKTDPAKQMSLLQAVAGPLITGLASAVERAQAEPTDLQAVLQVHHHLVALGHFAKGFPIVPDNQVESLPYSVPFMQMAEALLQAIEKLKGRRVVRDAARFAFSQFANAIGTPVAKLVPRFVSAVVTEFEPSELVDFLLFLQLLMHRLQGSSFETMDMLLLPLLSRIFAVLGQPVTGTDEAQVHTRLKDAYLSFFTTLMNENLDGIFITDSNKPEFESVLTALYNLVQDYADGTAQRLALGFFSRSVIAWGTSAEAAAKPSVFAETAQPTQSKMVSNGTAQPSTHAISLEQRAKQCLPGYENFIYQRLLPACFEVPANSEFNIRGGQLIVHEAAVLVRNTVQARGQEAVDFILNDLLPRLQCPPEIARQLVTSLTTQQAKDFKKTFFEFIKAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKU0</accession>
    <name>A0A1E3JKU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032929.1">
        <property type="nucleotide sequence ID" value="XM_019175197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKU0"/>
    <dbReference type="GeneID" id="30192276"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="109" mass="12053" checksum="8992F597E4C1736D" modified="2017-01-18" version="1">MPPQVKTKAQKAAAAMAGSKAGKKKKWSKGKVKDKANNAVILDKPVFDRIVKEVPTYKLISQSVLIDRMKINGSLARRAIAYLEKEGLIKRVVHHNAQLIYTRATAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLI9</accession>
    <name>A0A1E3JLI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032984.1">
        <property type="nucleotide sequence ID" value="XM_019175252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLI9"/>
    <dbReference type="GeneID" id="30192332"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="35049" checksum="653BD89437A805EA" modified="2017-01-18" version="1">MQGIGDASPHTPESVASWIRSFPLDPLEYEIDTTGKSTRKSASKTYRIWGDLDEKGIRVVHDQTLNGRISASLRSQQSSLSKGVTPFMEEDLRVARRSARRTTVEAEIHLRGVMRSNFFDCSTDAINSRLPSHLHGKWKPFSGEESDRLYWVFMRNGIAIAIIEVKMCTDLTTSGEGAVSQTDDRDHPPTEKVELCSRPQGDTAERGGAQSDASHSDQSQADKKEHSDSHHVPDNENELDEEISVHRPLKLERLLMACRQDGGLKLILASGTGKDGKVRPALRIVDQDGTIVPEMTYWAKEISQVSSENYYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLZ2</accession>
    <name>A0A1E3JLZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033116.1">
        <property type="nucleotide sequence ID" value="XM_019174737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLZ2"/>
    <dbReference type="GeneID" id="30191805"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36705" checksum="E812422C779C0C59" modified="2017-01-18" version="1">MSQSTAPSRRAISHGGSSRLSLSVDKATNAVPAPVFGRHPLRQDWSLSYVHRPPNAKVDYEKEIRRVATFGSIESFLHLYSHLTPVNELPPVTDMLVFVSRIARPGIWEEMRDGGRFTIRLVHPITPVLYESLLFSLIGDQFDESDHVVGCVLSVRQAEGILSVWVEDESDAVRSGALKAKILSLLNLPLTTVCDYRANRALLENANKSHTTTSSSSTTNPSSNINSNGTLPNNPIQNGTGTTPSGMHAHAHAGEGGNVEYQPRSYGHHHHERGHRERGERGERGDRGDRGDRRERGEAGGGSGSGTWSSAFRDQRRTGGPGPGAGAGAGAGGLGLGSGAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM27</accession>
    <name>A0A1E3JM27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033167.1">
        <property type="nucleotide sequence ID" value="XM_019174788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM27"/>
    <dbReference type="GeneID" id="30191858"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000007">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.138, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="776" mass="88039" checksum="CE15C47C59D62C77" modified="2017-01-18" version="1">MSTASPSSLIAEVLRQPDDLLKLAAYRKKLLKEKAALDTKLSEGVKSQLDATRDALVKLQNSKAAVSVIREEMLAVEKLMGGGEGGENFEKIIRVSAVHRNFAQTAKMVQNLRSMSDKVDHLASLLDSDKNHPDGSAGPSYNLLPIHFQLQQLEAFRNETLHQAKKSAPQEREILIKWFEKLDRVGQDFESWMWEIGGRIVELARKGNGSTVVRLLKIIEFEGKEDEKAVAMRLVRRVATSDAASKFKSMQANGRVIKNFRHKFLDVLKASIAQSFERHYLDNQYDFLAFIEDLSWVYKDIIRIKDDIGPLFPDDYEITSFLVKNYHKSLNDTLRKVVDSAPEAQVLLELHAWIKEYRVSMKELEVPAAWLQPPLLDGKSQDLIEDYVKLIVAKLEEWTVNLMKEETGTFTWRTREPEQGDDGQFGMEGVVDFFQLVNQQCDLALDSNQGAVLARVITESAKVMRRVQDEWLKLLAEEMKGHMEKKPEEVLPGLVEYVIALANDQLKSADYVEALLTRLEPLVSEKYKAVISARLNEAIDGYLDVAKRCTTALVQFVFHDLRVATKSLITPAWYQESLMDQIIETMKDYMGDYQEHLNPSIFEILVEDFLDTFLICYLSALRRASSNSLRIPTATQKIKSDISTAFSFFGAYKPAQQELEQNFEVLDMVVSMLDASPQMVFIDYWNFAKVHGPQLAFVEALMKARDDLDRDGVKEIMETLRRKVKEEEIGDPEEPTIMVKIQATSGGLFSNLTNLAGTYTSNFSAPKFSASGLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM34</accession>
    <name>A0A1E3JM34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033183.1">
        <property type="nucleotide sequence ID" value="XM_019174804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM34"/>
    <dbReference type="GeneID" id="30191874"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="868"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="963"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="930"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="984"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO01931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1135" mass="122765" checksum="2451DF8C55AD2EE3" modified="2017-01-18" version="1">MDTAYHSAFTRRPLAHPSPATAMPSDSRAAHHPHHPHPYAHPAHPSYQSPVPSYHAHHPPARHVSNGHPSQVVVPGPPPPSSVPTNGPPPAEPPVTAVVTPSTASARVARSLPPMSAEARAARERMDSILAQLANGAVAEGMNDQDRAESAFHNALRHNPSSILGLNAVASVARSRDEFDKAIEYFQRILNANPENGEIWGSMGHCLLMKDDLPKAYTAYQQALYHLSNPKASIPSEPKLWYGIGILYDRYGSFEHAEEAFSSVLKADPRFDKANEIYFRLGIIYKHQRKFKDSLDCFRYILNNPPRPLTSWDIWFQLGHVYEQDRDFESAKDAYMRVLRHQPDHAKVLQQLGWIYHQPGASFTDQDQAVSFLTKSLETDPNDAQSWYLLGRAYMAAARYNKAYEAYQQAVYRDGRNPTYWCSIGVLYYQIQQYRDALDAYSRAIRLNAYMAEVWYNLGSLYESCNNQMNDALDAYSRAYELDPANTPVKERIRLLQNPNAGPLPPPPTPVDVHPSQYPSMGSEGPGSPNGSPPRFMHLEGMSSRDGGRDLPPPPPGAEARAHSPGPFRNGAAPPPLQHVDESRGSMAGIAPLARMEVDPRAEAREERPNGSAGGRYDPLGRQPESPISPRAASSRRDVPPPFPPARGFNYPPGYDRSREEWEQRADSRGPPGPSPRMADRAPDGRERMHQEYAGYQQGYYDARGYPQAPPSAGGRYDPRREADELQAREDELQQPPARANGRRTSIAKEDLTRGTSPVPSATGGAKGRKRGEGKKTKEKEDKPASTKGRKGKAANLKAGEEANGQSPRTTVHTSSPTISVGTTPGSNAPKAMPPVQAPPQPLLSSMARTVDEDYDEGAADALISLAGGSTTNLPFPTRHISPSPSFAARHQPFPQHPPSLSASNKRAFDSQPFSPDQSNKRAKGDKVQSHSPPASATGSIGSRSGATSVPPAKKMVIEVLNAPSVASPLPRAASAVDEKESARTAPPSRPSSGGAQQERGKEEVQGTEDKMDVDAPAPVAEVTPAPSAPQSASPPAPTSAPSAQGPSPAARASPTPPAAQPSPKPPTPAASEPEKEKSWPSTPPVPQPNGAPVEEVKEKTATPPSAAPEKGVQKEDVVMGESEAYKGGDGEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMA5</accession>
    <name>A0A1E3JMA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033242.1">
        <property type="nucleotide sequence ID" value="XM_019174863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMA5"/>
    <dbReference type="GeneID" id="30191934"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="257" mass="28118" checksum="F5F34CD0A6823E8E" modified="2017-01-18" version="1">MSTAGPSRSPHPSSRYHPYTLQPSSPQDNPRSQPQVKARRNHDPAPTNGEPPSPPRSRRDPSETPSVSLSMAFGGSAGGKWWDEELRLSSMIHTRLTILQARLSLHQAALAMNAAGAPPMPAEHYPRPPSEADLRARSPERTPSLSTSRDSASASSDRLASPTGGNEYMLPPPVRHGYEVYEKSMDKAADEARPRYWQLPAMSQAPARSSRQLSPLRDVAKERLVSPKETAGRDRSGSGIEMLLDAGMRGLESERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR51</accession>
    <name>A0A1E3JR51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033376.1">
        <property type="nucleotide sequence ID" value="XM_019174324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR51"/>
    <dbReference type="GeneID" id="30191383"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="713"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="899" mass="97877" checksum="97191740AB6529C8" modified="2017-01-18" version="1">MPPRKAAPPPSPARSARSARSNTHDRTNDDEWDRESITSGAFKVPSSRGKTSNGGGFKDTSVNIATAFHAAQTGHLPPPSKSNLSLTSNGSSSRSLQVPRAISPAESLAQSARALSPVRFFLRPTDEDGEEFSSFSSADNTSANKSINTSGEGESYDYYQEEEFVRRAQQQQKAARGKTGPADRKRRGKAAAEDMPYRPAEEDAVSLASDDSGGAGEGIVRSGALDGRAGTRGKRAERGEGYLGMGLGLQPKRRGKGRRSGGAEGETDDDGTPGPTARGWTPALELEVPRRSPTPAQLLRALSPRLDRRSPGPSMGYQPRRQPSDLRTILTNLLHGVALGLQFVVEIVSTILDRIMLRPISAVFGTSRDFTRLARDNWWKWAGLLLGLSLAIRLFDGAWRSRGIYTAPDAPPSNIDEMSNRLTSLEQATAVLSDMLRAISEGDQDLQQSAVAIKSRVTDVEDSIVAERKRIEGVKGDLKHQKTAITSEIDKLRTEIHTITTQSAKHEKLLSASDKSAKTIESLEREIAQLKTRVGTVEQSVHVALEDGRLVAAIEKVLPHWMPVWTDAKGQVQVEPAFWAEMKKVMVGKGEVETIARKLITDSIASDGGVPEMPAFDQRKVEEWMDKAFDRRSADSFMDRQTFTQMLDEKLRELARHVPASPSKQSVPSSTVTIKSSKGEDLTSLFTSLIDTALLRYSKDTLARTDYALFTAGARVIPHLTSDTLTLRTASGLGKWALGRKDVQGRPPATALHPDISVGSCWPFQGEAGSLGVMLVDRVVVGDVTIEHAPKELAIDVATAPKSVKVMGLVDTEENREKLASYWAENPTKDPTDVDYLPLGTFTYDPSAYSHIQTFPVPPDVVNLGIPVGVVIFKVESNWGGDLTCLYRVRVHAAKDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR87</accession>
    <name>A0A1E3JR87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033449.1">
        <property type="nucleotide sequence ID" value="XM_019174397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR87"/>
    <dbReference type="GeneID" id="30191458"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="540"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="725" mass="79826" checksum="EDAF59E5E3845BD5" modified="2017-01-18" version="1">MASPATSTAPLPRQPGPHAIPIMDPADAPQTSSPTKRAYQAMETPTTGPSYPPISETTSKAFSPDISKLKIEMTEDDGPSPFWGMGGASLGTLNKRQDGWAYQTPRRFSIPRSSSPSPGLTTTPYTPQTRYSARSAGIGTPVTPYTPDYPTLDYRRHSETSDAMHRATQKPFNKPVEEEYTAQTLGRYLLITNVPMNVRNDDFRDMIQNIAEFKALIVKHLQTKGCVIVAFHDPRENLKVYQRLQAGPINIGSAYPSLNLSCMPVTKDLVESVTGHGPAWEEVWKTSEAVVRIDIDGGNPVNPDAMHRVVGAIAPYQSIEPIGYDCRSYVVDFFDTRDAATCIRTLDGHVSGQAYVSADYYDPTPRYAPTRPTLGSRAFSLGSAAFIPGSLGLPKTDSYSDVFSLGHSAESTGVHTPSSATFNRLRSDDDIFTSRSASLSPTKREVSASGPAYNAASPWARRGSTPAVFSGADTPPRMLSLSRRLSEAGTVQGLVNKADITARARQRQGLGGHWDANDRKSIPEQNRVFPERIVAGLDHRTTVMIKDVPNKLSRQELVEILDEVVPSEFDFVYLRFDFKNCCNVGYAFVNFCSVSALVRFIQARVGKKWNMFSSEKVLQVSYADIQGKAALINKFKNSAVMSVVESWRPQIFYSSGSMKGQPEPFPVSDNLSLRERSGAGFAGENFKMSWPDTANKIIQARHPATFSESHERPYEYAQTCFDHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA9</accession>
    <name>A0A1E3JRA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033469.1">
        <property type="nucleotide sequence ID" value="XM_019174417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA9"/>
    <dbReference type="GeneID" id="30191478"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="38390" checksum="948EAF0483E1C695" modified="2017-01-18" version="1">MTQVDTADHIILCLPLTPALFTAPQPLVALILDILPPSASKSFTVFFSTPKGALANAQSLIPGKGSDQEQLYSLLQRSPKESFAGLQSFLGAIYTALWTAQWKCGKVLLDVEVHFEGEGGSLESKLCRGVAEAEEYHIVKIDGVRETDVVSSIDKVVPAPFTEISITSPSLASISPEQFSLPPSSGFPVVALGGTFDRLHAAHKLLLHLGVFLSTQKLIVGIMADNLLASKTHAELVQPLAERLDNANAFLARSGASDTLQLDVLRIDDALGPTRTDPDIQALVCSRETLSGGEYVNSSRKGAGLEELELFVVDVIAEREEVDLKQEVDEAKLKKMKMGSTGVRSWIAERGTGQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRY3</accession>
    <name>A0A1E3JRY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA (Uracil-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033699.1">
        <property type="nucleotide sequence ID" value="XM_019174647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRY3"/>
    <dbReference type="GeneID" id="30191712"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="615" mass="68285" checksum="1405CEEA45149426" modified="2017-01-18" version="1">MTTTLSPSRSPPPKRLKTQQTKDLLDVTEAPVNALFVPPTEIEIDAAPTPTPAKGKKPKHNRPPRPPKAQTKKERRRRPLPESFSPADVLWHDIKDFLGEDYVQEVIGRGEHEEWEAPEELGPWEIVEVRAGGWTRGGESLSLYTSPSTSKKWAIITPFAHPGDLIRVKIHKHDRLHCLADLVEILEYSSEFRGGEGDRRVNPEGGCKYFGECGGCQLQPLPYSLQLEHKLQTVSLAYTRFSTLPPHLVPTILPTIGSPKQWGYRTKITPHFDAPPRWARNRLDKAKDGGEDEFAMVEQEVAQEIECNVGFERKGKPGVLDIEECPIATPVLNAQMALSRPVIKSTITSYKKGATILLRDALAPPDPLPTAEHPWDAEKHVEAESDHVAVTDHKQQVYERVGPWLFSFTAGSFFQNNNSILIPLTTYVQEAIFPPPSSPYYSPSTPLPTHLVDTYCGSGLFGITLSPKFERVAGVEISPMSIEAAKVNADMNGLREKTKWLCGKAEDIFGGLAEQGFAGGHSCVVVDPPRKGCDAPFLQQLLTFRPLTIVYVSCNVHTQARDVGYLVHESNKLGAVKEGEEGEGWKYVLESLRGFDLFPQTAHVESVAVLRLTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUH6</accession>
    <name>A0A1E3JUH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033633.1">
        <property type="nucleotide sequence ID" value="XM_019174581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUH6"/>
    <dbReference type="GeneID" id="30191643"/>
    <dbReference type="OrthoDB" id="2574428at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="629" mass="68458" checksum="950C4F8F12981FD4" modified="2017-01-18" version="1">MSYHPALPQISSSSTTRFVPPRIPATDSRQQSWDPAESSQSWGGYDWCDPPQPHLEPQLSNLPAFNPPPPPPVSSAQTYQYPGMLQPTTTMASTAFQDTGSFYGIPYPIQDIDPHQPIPSLVDSRSSSGSSVSLPNMPRYPQVIIPHPHAPLNGTPLISPSPIPLLNLNATLPYLIHKTPPVIPSPLPPAPVLYDTVPHLQRPVPPRDGQDGYAGGMPEGTFSVGGGGEGMWRGMMPESGMGMVSPVEDRRFSAGSQAQVPTPSSDPIQHFGGIYFTDPFPPSSAPAPAPPFSSAPGPVPAPPTQIVSNPSPISPSSFLPPPPKHSYRPRDYTPPTPPPGRLSSPRPRPLPAPFRTFNSYQEMLHDRVDEYGARAMSMPLTHGLMLETQRKKRLGLVVAVGGGMREDEGARLLRTGLEKEEAWDKNEEERLLRKEGMLSPLPLAEEDEDENEEMPLLTTEAMWSPREDDDLDDGFNGRPSGGGRRAKRAKKVKKALNAAARKVKKFLCTECNEGFTRKNDVDHKSSPGLAPHVPADSDGKTKWNCISKKTQRADNARHQKKVSPVPPLSINFLLAGVCLSLSSSFSPPHVSHQSNTTSLPVSRYRAIRRRRSSANKENAVPGSSAIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF1</accession>
    <name>A0A1E3JWF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033778.1">
        <property type="nucleotide sequence ID" value="XM_019173971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF1"/>
    <dbReference type="GeneID" id="30191024"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="40249" checksum="C4C1DE512CCC96A4" modified="2017-01-18" version="1">MTSMDLRVGGKYRIGKKIGSGSFGDIYLGVNIVSGEEVAIKLESVKAKHPQLEYESKVYKTLAGGVGIPFVRWYGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTALLLADQLISRVEYIHSRNFIHRDIKPDNFLMGVGKRGNQVNVIDFGLAKKYRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQSRRDDLESLGYVLMYFLRGQLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGYPNEFAIYLNYCRSLRFDDKPDYSYLRKLFRDLFVREGFQYDYVFDWSVQPKSSGSGSGTAGDDHMGQHILSGGKRRVVPNDGGVAQAQDSQRQLRSQTRARDTGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWI0</accession>
    <name>A0A1E3JWI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033873.1">
        <property type="nucleotide sequence ID" value="XM_019174066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWI0"/>
    <dbReference type="GeneID" id="30191120"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO05218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="300" mass="32545" checksum="C879589E577CB7DC" modified="2017-01-18" version="1">MDPTQYTGDFHRASEPSTGVLLLEFNRQVAILPRPRADRTSRAPVNAFHDAQVLWQEMHRIVDDVSNDPDVRCIVLSSALENAFTAGLDVTKSELSSGKTFLDPARRATSLRAHLLKFQAAITSLSRARQPVVCALFGSSVGLAIDIASACDIRVCASNVKFGIFEVNVGLAADIGTLQRFPKIIGNDSKARELAMIGRPFGAKEAEEIGFVSEVAQGGRQEVIELALQKAKMIASRSPIAVIGTKEVMNHSRDHSVDDGLQYVATWNMAMLQSEDTPKAMGSALKRTPVTFDPIAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWR0</accession>
    <name>A0A1E3JWR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033949.1">
        <property type="nucleotide sequence ID" value="XM_019174142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWR0"/>
    <dbReference type="GeneID" id="30191199"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="74846" checksum="A26BB682431D491F" modified="2017-01-18" version="1">MDRQHSSSGPSPPLAPPAKTAPLSSPLIIPSDDVLVSPAALLTSSPPSSSNSSSSSSQNSSPPRSSILRRTVSALPASAQIGSSSSNSSASGREKKILRFTQVRVESTVVSGKGKEKETHEEDEEMFMFPGKKLEEGLYIRGKKGVPKDQRDYLKTEPGTPNFSETADQIRRTLSLASLDQLAILSASHEERTRLITEVSRAGRKLVWRDASERPLLPQDTERAALLALKRGLRSFILAFSVRSGVNVLLLFFRLLRRVHPRLTPLLLLRTIFSPDSWRFGGMLGSFTFLYTYTLHLLRLAPPWSYIKKRFRYGMWREVSFGPPEREGSEGERRWQAAVAGAVGSLALLWETKGRRTGVSQQMFVRGLQAAYNQYTPRLGIHIPHGDVLLFGACCGQIMFAFLMSPETIPKEIRSASRVPQFAITANRTQVRQGFVGEDMIQQALNSKGITPENRIRLTDYLSSIRSGHQPNAAPCAMIHPWRSDCTSTNLARFFSVFRFMLPMYSALHLIPMLVLRRHSMRRNPVGMLGKALLGISRSCSFLGVFVFIYQALFCARVQTLEHGRGPTWLRSLLQKKQVFWGMGFATCLSPFVEEKARQKRRAELTMYVLPRALESAWSGARKRAWVPIVPFGETILGAVAMGMVMDAYKHQPDAISGIVRKLLFQIIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWS2</accession>
    <name>A0A1E3JWS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033905.1">
        <property type="nucleotide sequence ID" value="XM_019174098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWS2"/>
    <dbReference type="GeneID" id="30191154"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="356"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="499"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO05250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="765" mass="82738" checksum="1A2C102E79033DCA" modified="2017-01-18" version="1">MSRPVDLSMSSVKNHSPLNPGGSGGFTPVFEASPAVSPASSRRPSISQPVARRPSESASASRRPSMNQYYSSSQQIPQQISQPQQALSRRSSMASGPRPIRRGEYSGPATPSVLSRAGSPTLPLGNEFTQAPRSYFEGAAGYTPLGGVRELRNGQFIGSLDCGTTSTRFIIFDKRAKIVAEHQTEFEQILPHAGWHEHDPEALVEAMNECIIRAVEKLEWMGWSRNSLKGIGITNQRETTVCWSRSTGKPLANAIVWDDARTVSVVKEMEKKLDEIGIRIESAEEDARTADTALTEEVVLGTGGEDAAFGDKGEVVDQAAGVTGSIGKAMEGLGIGGGKDEKEPVVKGTKFRKGKEGLVDVTGIPMSTYFSAIKLRWMIDHQKAVRTAHETDDLMFGTVDTWLVYNLTGGKQGGLHIMDVTNASRTLLISLKTLQWHHPLLEFFGLRASILPKIVSSSEHYGNIHESTNLPIPGVPIAGIIGDQQAALVGNKCLRKGEAKCTYGTGAFVLFNTGEEIVRSNYGLISTVAFQPGPDAKPVYALEGSIAVAGSAIKWLRDQMDLIEDSSEMDILAGSVHDTGGVYFVTAFSGLLAPYWDREASGTIIGITAYTTSAHIARATLESVCFQTRAVLDVIEKESESKLSTLKVDGGVTNSDLAMQLQANLGGFNVARPSMRESTALGSALLAASALGLFGWDLSKPETLSEVNTAGVHTFEPELPEKSRLKRVKGWNRAVSRASKWHEEDSDDEDEEEYEKSMGFERINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT6</accession>
    <name>A0A1E3JWT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033925.1">
        <property type="nucleotide sequence ID" value="XM_019174118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT6"/>
    <dbReference type="GeneID" id="30191175"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="134" mass="15283" checksum="945064069B9612FC" modified="2017-01-18" version="1">MRSSRTLIERFYPRLTLDFHTNKRILDEVATVPSKRLRNKIAGFTTHLMKRIQKGPVRGISFKLQEEERERKDQYVPEVSALATSDESPLEVDTETKDLLKSLGFDDLNVNVNAVSANAPRERKTRFVPGAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWX1</accession>
    <name>A0A1E3JWX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033985.1">
        <property type="nucleotide sequence ID" value="XM_019174178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWX1"/>
    <dbReference type="GeneID" id="30191236"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="355" mass="36776" checksum="D141186FC5B050B0" modified="2017-01-18" version="1">MLRRRLSTGLLRAAPAPAATPIAHHARSRSLASAVLLSSERNWKTETVVGLKAELKKRGLSQKGNKATLISRIESAETTSLLGPLPPFPSGARALSTSSPAAFPPKKKASSAPKEESHGVAPGVSTTDPALQVESQRTAAVHPDPVAPEQITVAPGLPESKNAAGSGSSDLRIPVTTNAVDSGEIEQVIPLTPDNFASNSALPSSSSPSKDPKVLTVASASTHHAGGPVHGVHDHTDAYALEASELELPSFEGFTSSIWNAPSAAWNALSFSLPKAEKKDYKYEKRALDGHERTGAWILAGVIGTGLLVGGPKKEKKSHGDVALGVEAVASQVKGDAQWEKASGAGVVGHGSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX07</accession>
    <name>A0A1E3JX07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034059.1">
        <property type="nucleotide sequence ID" value="XM_019174252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX07"/>
    <dbReference type="GeneID" id="30191310"/>
    <dbReference type="OrthoDB" id="10287644at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="295" mass="32744" checksum="1693BEA4A9F9E374" modified="2017-01-18" version="1">MSDFWTDEHYQDVLLAADSVRAGGHGSSFAFGPWERMHLAIDKGGDAPHYEYDVFNFKGVGQQSAPPATRIQEHNAIIHDVEPSAVSYTLLSRYTPNPELRTWDIAEFSQLGGPHPLSGLWSGLCDCDQPECVLQSVPTELARELVNSINTDTLHDTELCEPRPAGHHRSLFTKLPWEKADIIVTKPDGTFYTESGVIFSTVGYRDDPENAARDNAADVHDVSPDDVYATTLARYTPYPALRSWYIETFSLYERGQGAEEVARSRLCDCPNPRCTLADVPSEIAESLHTAIETGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ08</accession>
    <name>A0A1E3JZ08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tartrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034102.1">
        <property type="nucleotide sequence ID" value="XM_019174295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ08"/>
    <dbReference type="GeneID" id="30191353"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="505" mass="56349" checksum="F214A153CD92E01F" modified="2017-01-18" version="1">MSTAHQGELKPTESIISHVQKPHDVEAAREHDERRKTIEKSLVRKLDLRCSLFILLYIMNYLDRNNISAARLRGLQADLNLTDTEYSTCLSILYVGYILMQIPSNMIINKISRPSWYIGSAMLLWGMISTCSGVTKSFGSLVATRFMLGFVEAAFLPGALLILSKWYTRRELTLRNAILFGGNLISNAFASLVAAGVLSNMEGTLGHAAWRWMFFIEGAATMFFALLCPLILPDLPTNTRGFTSEELEVAQLRLLEDVGEADQDSESDGVFTGLMMAVKDAKIYIMMLTLTAYVIGLSFNAFFPTLTGTLGFGYVPTLLMSAPPWVFATLVSFAVSWHADRTQEKFWHIVIPILFGLVGFIISMATLNTAGRYVALFLQAQSYAGFIVFYSWISSSFPRPPAKRAVAIAMVNAFSQLGNIAGSYVWNLQENGYRKSYGIVVAMFGITIVGCFVFKTILVKLNKQLEAGDAAWEAREDVVDKGQKLEHFEQKDEALKMRKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZC3</accession>
    <name>A0A1E3JZC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Syntaxin 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034223.1">
        <property type="nucleotide sequence ID" value="XM_019173518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZC3"/>
    <dbReference type="GeneID" id="30190568"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000069">
        <property type="entry name" value="Related to syntaxin 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="399" mass="43995" checksum="A545B60025E0632E" modified="2017-01-18" version="1">MAPIDQTDQLRSILSTKQSALPPSARSKSPPPRGGRSASRGKGKGKQGDEDEESFLKESYQIYTHLASLRHLLTSVRKPYLSSAEPPPMSRRRPQRPTSSQAGDDGQVEEWAKWEKSKYLTDKERDEIDLRARMILRRCNERVGVLERAEKARKTKVNSSLPASSLFQLLPSLALPSSPSTSSEPIISAHHASIIWTLNDTMAKLTGTLSDMQTERVKRREERGRTLGNGASAEAERLGRARKAGEGRLIPDGVVVDVHDAALSPTMGSDPHLHSGLGIIDPSAPPIESQLSQAQMQEFESENNALLEHMSSTLSSVLSAESSLLEISQLQSELVRHLAQQTEVVEQLYEDAVGSVAEVRKANEQLVKARERGKEGRLFLLVFILGASFSLLFLDWYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZD3</accession>
    <name>A0A1E3JZD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase DBP2-A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034279.1">
        <property type="nucleotide sequence ID" value="XM_019173574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZD3"/>
    <dbReference type="GeneID" id="30190624"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="146"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="349"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="498"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO06179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="57513" checksum="F52129F04BB4D6AB" modified="2017-01-18" version="1">MSYGGYGGGGGGYGGGGGGYGGGGGGYGGGGGGYGGGGFGGGGFGGGGFGGGDRMSNLGQGLQNIDWQTTTLTKFEKNFYVQDPRVTARSDSDIDAFRASKEMKIQGKNVPRPITTFDEAGFPDYIMTEIARMGFAAPSAIQCQAWPMALSGRDVVAVAETGSGKTISFALPAMVHINAQPLLAPGDGPIVLILAPTRELAVQIQAECTKFGASSRIRNTAIYGGAPKGPQIRDLQRGVEVCVATPGRLIDMLETGKTNLKRVTYLVMDEADRMLDMGFEPQIRKIVSQIRPDRQTLLFSATWPKEVQRLAMDFQHDFIQVNIGSLDLTANHNVAQHVEVCSDFDKRQKLLAHLEKISQENAKVLIFVGTKRVADDITKFLRMDGWPALAIHGDKQQAERDWVLAEFKSGRSPIMLATDVASRGLDVRDIGYVINYDFPNNCEDYIHRIGRTGRAGKTGTSYTYFTTENSKSARELVQILRESKAVIPPELEEMALYGGRGSGGGRGRGGRGGGRGRGGFGGGRGGGGYGGGGDGYNSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZH8</accession>
    <name>A0A1E3JZH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033967.1">
        <property type="nucleotide sequence ID" value="XM_019174160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZH8"/>
    <dbReference type="GeneID" id="30191217"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="40231" checksum="9FE37DB4348B6F60" modified="2017-01-18" version="1">MPDIESLKDRSAVGSMSCERLPIIDISPYLDPTSSEASRKTTSQNLDSACRDFGFFYVTGHGLSPDYLKSLLTLGHQFFELPQEAKDSLHIFKSQDGVRGYQKLGENVTYAKRDQQEALDIYPEPENPTSDQLNGSQPWPADSDLPGFKTTLLEYTVKMSTIGHAFMRAMADALGHHPIFDELQKDNYWVLRVIGYPPLPEEFDPEKGISCGAHTDYGQTTLPVPFKVLTLLNSPKLLLTEPSVESKDGSWIPADPVPGAFVVNIGDIIDTITGHQYKSTYHRVIHKSPTYRVSMPFFFEPQRDQVIEPLEGFLPEGSKPTQAFTYFDHLKSMIYNHFVSNDKPLPEKPNANELTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K004</accession>
    <name>A0A1E3K004_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034453.1">
        <property type="nucleotide sequence ID" value="XM_019173748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K004"/>
    <dbReference type="GeneID" id="30190798"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="274"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="48007" checksum="E4E4C825AD6327D1" modified="2017-01-18" version="1">MSHGHTSARHSGGIESGDEIDTETKIAMLASLVDPSSFSTDQYLEALASSQGNVASAAEQLLMPRSITVLGKRKANPTLKGWLGQPTGATVNKGKSNEAVDSTAASKPFKTQASSPKHAKSNDTSPNAFSLPKQSSSTTSISVQPRTQPQGPIFLSSQASIDAQSLPLSVFAQPLPPSLASALYLLMMEESEKWGNNRFYIAGKAAKSPHTTSFYARREGGYGNGRYFYAGMEQGPAKNYFPVLEEAASLVEDIVNEHLQQRQRYPLEWAGRWRANVCGANRYDGAKSSVGWHADQLTYLGPYTTIASLSLGTTRSFRLRETPVSDRAFAVNDKPPRTFELTLSHNSLCLMDAGCQERFKHTVPTQKAIDMYRARFDTNQNPIAEHKQAASTSRINITFRFYREAFYERIKRPKHGHVKHQKQYESQNTTSLTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1V7</accession>
    <name>A0A1E3K1V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034625.1">
        <property type="nucleotide sequence ID" value="XM_019172899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1V7"/>
    <dbReference type="GeneID" id="30189940"/>
    <dbReference type="OrthoDB" id="10658120at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="275" mass="30106" checksum="1D1D25D7A4476D51" modified="2017-01-18" version="1">MAPGYSYLPKLDLKDISVEAAAFGQLKPASNKNSDHSVQAGQATNPSAPSSQSSDSIRSSSSSEPDTPASTTNLLANENIMPQQINSLQRALTEAQKEKNKLAERLGQERKRNKDLLLRIQGDRIDPAVITLLACRLAEHGGKETDQSNGVAEVAAALIDEVDRAEVCGGGKDGQMVVVGDDVEAARRDWNEGKEMRIWNLEGVVEVMLGRVDSLELEVSKLKRERGRETSLGMSWTEDMEWDEEQETLGLVESTASQLSRRLDKLESDVSTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K226</accession>
    <name>A0A1E3K226_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034597.1">
        <property type="nucleotide sequence ID" value="XM_019173892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K226"/>
    <dbReference type="GeneID" id="30190943"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="33156" checksum="7275EFA9FE5386AD" modified="2017-01-18" version="1">MAAIAPALVALLERAQRPDRLGSLLKEAVVLVQTVLELLGEEAVGISFNGGKDCTVLLHIYAAVLYARRTPTLPEGLLPKPSPHIRLPQPQQTLQPSISPQPSYNPSRPARTPPPVLSPLPTIASAPESPPHPHSTHHHPPSPLPYQPIRSVYITAPNPFPELDEFVLACTERYGLDLWRFGGGMKSALEEWLKCGGGKSVKGVLVGTRQGDPNGEVEVLAHTDPTWPQFLRVHPILHWTYSDVWDFLLELNVPYCVLYDEGFTSLGSTTNTSPNPLLKKEVGGWEPAYKLQDASQERAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K242</accession>
    <name>A0A1E3K242_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034715.1">
        <property type="nucleotide sequence ID" value="XM_019172989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K242"/>
    <dbReference type="GeneID" id="30190030"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="177" mass="19439" checksum="EC48E81207E95795" modified="2017-01-18" version="1">MSSTGWEVRFSNSRQLPYFYHAQQATSTWEPPADLTPEQIQQLPGASQYLNPQTKPPGGKDGQARASHILAKHSGSRRPASWRSDNITISSAEAQSIIEKHVAYLKSLPKEHLAREFAKIASTESDCSSAKKGGDLGWFGRGQMQKPFEDNTFSTPIGELSDIVKTDSGVHVILRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2I9</accession>
    <name>A0A1E3K2I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034693.1">
        <property type="nucleotide sequence ID" value="XM_019172967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2I9"/>
    <dbReference type="GeneID" id="30190008"/>
    <dbReference type="OrthoDB" id="2560253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130718" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="16966" checksum="97AC390E919B9BC1" modified="2017-01-18" version="1">MFKPIVALIGALLCLLPFTQASAAAQFNLDVNKQASLCFQTCHSAIVGSLALEETDTNAYQWIKQNCKYDKWQAAMTLCLPQYCTSAPDVAYAMEYAKGFCARAGVTVNIELPESYLSGVNGTYFTSEEYLDSASSAGSMPSGLLAGVVAMGVVAVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2J3</accession>
    <name>A0A1E3K2J3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034703.1">
        <property type="nucleotide sequence ID" value="XM_019172977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2J3"/>
    <dbReference type="GeneID" id="30190018"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="33490" checksum="6FAB1FC6CA46572B" modified="2017-01-18" version="1">MSAPKTDIKSSHDTLGRGVFGTDALDITKLFDVKGWVAIVTGGGTGLGLVTAGALAKNGATVYITGRRPEPLQEAVKTASPTEGAGKIIPVQADMSSKEGILKLKEVIEKEEKWVNVLINNHGVSLDVPKINEAEQTAQGIAKKMFEDETFESWADGHRINTASYYFTTFAFLPLLDAAQKVGKYSEPGNVLNISSVSGITKTSQRGQFSYNSNKAATISLSHQLATEFARRGLGIRVNVVCPGYFPSGMSPVDEKYLKPSEEFKQKYGTPLGRSGNAQDYAQCIFGLINNQYVTGAEVVIDGGWLLVQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3E3</accession>
    <name>A0A1E3K3E3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035028.1">
        <property type="nucleotide sequence ID" value="XM_019173302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3E3"/>
    <dbReference type="GeneID" id="30190343"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="44567" checksum="95DB299F58D30535" modified="2017-01-18" version="1">MPVALSKSAAAVTAEIGGQENVDQLNRVSRDFRSDTVTIPTDNQLLYALKATRGDDVYGEDPTTAALEKRVAELTGKEAAMFAVSGTQTNQLAIRTHMKQPPHSVITDWRAHVHKMEAGGIAMFSQATTHQIVPENGVNLSLEDVESNLQLGEDIHIAPTKLICLENTLSGMIFPQEEVVKIGELAKKHDIALHLDGARIWNVAADLTENSLTELIAPFDTASLCLSKGIGAPIGSILVGPKDFIQKARWFKKAFGGGIRQAGGITASADYAITNHFPKLAVTHQLAKRLEQGLREAGCDILAQVDTNMVFFQPNKIGLPLDTVKARLAALPNPITIGRERIVLHHQITPEAVEDFIACVAEMKQEKLESGELQTEIDAEAKRMAERYATPEGEGNTSKSELRRRAALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3H3</accession>
    <name>A0A1E3K3H3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035058.1">
        <property type="nucleotide sequence ID" value="XM_019173332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3H3"/>
    <dbReference type="GeneID" id="30190374"/>
    <dbReference type="OrthoDB" id="2574359at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="744" mass="79397" checksum="FB149F3729808C6E" modified="2017-01-18" version="1">MANTRPYTRDELKSLRRADLQTLFKVHKLKGATGTSAVLIDHLVDFFASPAYQDAYPPPTNSQASQGTVQGNAGKREIMYKALPQRTAVAKGAAGGVRRKAEGATVRAGTKGAAPTTAPVAAPKQAPRAASRMAGTVRKRGQPQKEVQEEVVQEDASAGQEEASIPANQPPVFTPRPSAIPQPISSSPPSIQEPAAPPLTLADVQTILRENDEKWKDQLQAVEARLGQEVERLRSEVQDVRRKCEELERAERARAPRPSSTTPGHPSILGGQNAPYTSHQRSASVPWSGSYSSLGKRRHPHERVESEDAEAKRVRFNANRAGEPASDATTSDAQSQPRTPSPRQAPSSFPPNFFAQPALPATTSSQASVLPRTPSPSRQGIVPDNSQTPRPPSEWRAQYEYAPETGPLRTPYNIERTPEFATTPEPPLRGDISPSFDGGVLGGRLTPGHIRQNLPSTPDQPDEEDFAPSGIALSTVTDLERIDESEELPPSRQTSPASHLRAQAKAVLGLGVGATPSSASPKPQPRSISVPNQPTTPSLLGQHSLLGPPAFIARTRAGSERPSFSARAQTHSPPPRPRSASAVHRPSGGGPGRRTPSNSRHASPALLATVIPTERDESRVRSASADYMRIAKYGFETSWDTIDDADLSPTALPIHRPTPTFSTITLPAPSSIATDTPGPGGSGSGPAGAGAAERTRWIKKDEVATPGQRTLLGTERYNDTRFGDMPVGFWAQPGVDLGTPGTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K473</accession>
    <name>A0A1E3K473_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035100.1">
        <property type="nucleotide sequence ID" value="XM_019173374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K473"/>
    <dbReference type="GeneID" id="30190417"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14310">
        <property type="entry name" value="UBA_cnDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="42385" checksum="AD24213D3B2D110B" modified="2017-01-18" version="1">MRLTIIAPETIHEHEVSPELLVEDLIALVEATAELPPSVIVLTSDSGTPLTDPSRTLDSYGLNGEHATIFLTPTEQPVASSSSSGPLAGSDADIERMRLQALGNPELMESLQERDAELYAAVRKGTQEFKTALQASQLRQRSREYEKEQQIAALNADPYDIEAQKKIEEAIKQAAIMENMEHAIEYSPESFGNVTMLYIDVEVNGFPRKAFVDSGAQSTLISPRLAEECNLMRLADTRFSGMAEGVGSAKILGRVHSAQLKVGPLHLPCSFSILEGIKVDLLFGLDMLKRHQCCIDLPKNCLRVGDVEVPFLAEHELPSEKKREEDRKVAEDMRDAAAMGKKVEATSSAAAGSSFPGAGQSLIGLGAPRDQAIQLLEASGGNVDVAASMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5R6</accession>
    <name>A0A1E3K5R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035286.1">
        <property type="nucleotide sequence ID" value="XM_019172344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5R6"/>
    <dbReference type="GeneID" id="30189374"/>
    <dbReference type="OrthoDB" id="2584808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10337" checksum="87B5925703391115" modified="2017-01-18" version="1">MSLAVENYLTLKGCLGIIEGTDVEPSRAEDKARTVRAGSVPPTEKKMDDDAKGDWEEWRKREACAQGVIKSSVDAGFLVDIRDLFSAKDMCGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5S6</accession>
    <name>A0A1E3K5S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035384.1">
        <property type="nucleotide sequence ID" value="XM_019172442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5S6"/>
    <dbReference type="GeneID" id="30189472"/>
    <dbReference type="OrthoDB" id="2596771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="878"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="962" mass="108252" checksum="C9DF101176B8B5BA" modified="2017-01-18" version="1">MSQKDIQVSQFQQGVLPSSSFEDKLDLVIPRHQKNFSTATAVSSKEKHKHENLRLTVRRPEAGLNKMTLSKIRPSGRHGDSQKEMYITSNIKITELRQWFEQEPHDYHQTDFVQHLHAEIKWEEVHIGLFPTDIRARPFSVVCDDSIKPRGKRVIEDTPVLRVVFACSGSCVCGKPSPDVKRSEVEDDIDDAEDFDDEVEEEGHVKCSVGAKIKVEMTVKQACMGECTITHMPISEHKPPPESLRYHLKGSRVLRRWLFLQAEKLGVTPSAIETVSVTISIDGTSGTYRRLLEDVSKAIFRFAKKIVETEPGHQTSFPGIDHHELLQACRMVVDQGRFKPAFMVIDGCTAESKAILEVWPDMIIRACQFHVMQALRAKVRSFVTWKKGEAKEEVVNRVLESFRLLQRCNRSSDFGPSKELFSTQLNAISGSHGGFVKKVVDYLDATWLSSRWQDFVMDWGMSDGLTRTGLLSTNNHCEGAFRTFDRVILRGTINRRNDHLLFLILFYWFPRYRNSSVSQKRLPKSDKQIYQKAYHYWESGYVQNASAMDIDNSVLKSRTLVKDFADSDEVWEILIPDQETATAGRLHNGNMTDIERKLQQMQTVVDGLQNVQDDEGAKGDDGWLEEYRVNDVFDSFDDDESDSDDLDDTHPIGCQTAPKGMTPQPTQPQTSVLESTTSGGIPPSSCLSVVEATTTTTLPKAKIPAIPPQPPALPHPSTTNKPSSAEDAAVSDSDDPVVVLTNPPPSSSFPKNGSSQACAPLSTGRPAKHQPLNPRRRAPKSASKGQHHQQGTGIVNPRVPLSLAAGDKAQASRIINKQNLHRRRVLDTLRPGAYMMCEVYDLYVKLLRERARLAGQPHWALTTLTSSFLTRDDPYSQIAECEKLGSETEKINLFNYFTVSIPIYTPHHWHAVIVNMTQRRIEYFDSFHGSTDPEYTRQKRIEYSEAVGDDVPGAVSAVVPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5W0</accession>
    <name>A0A1E3K5W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035308.1">
        <property type="nucleotide sequence ID" value="XM_019172366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5W0"/>
    <dbReference type="GeneID" id="30189396"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="311"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="961" mass="102838" checksum="6CFE4CC1060A43D2" modified="2017-01-18" version="1">MLHASNTSPSPASLFISRLHAPVTQGSESTASGPSGQAGTDRRRTPYLRGTEGEASDPVPDPSSSRGAYPNTTSYIPPAASRHPLFAHHALSPQRIAGPSGSQTVAEPPLATPAPQRQLSHVGESSTASSLSSPPSIRPSPQPSPASLFISRLHASKAAATSADEPGTPAKRTINEGGLSGGSDLRRISSLRGGASGPSFGEAASNMSSPQGPNPNTVYTPPAASRHPLFSHHANPPQRQLSYRSNGGASPSFLSDPGPSGPPSPSISDMSNLSANAFSPANHFLSYFSSSSSGGASQVAPDAEGARVLGYTLGKLVGRGGFSTVRKAILVKTGEVFACKIVKRDDLSDRSGSLEKFEEEIQTWQNLPKHPCLLPLLDMHRTPSVTFLFIPYMPGGSLLDVLQKEGGSDKTARKWFPGVVAAVSAMHDGYSGFPGGLLHGDLKLDNFLVDLSGKVMVCDFYMAQQVGIGEPRRGREMATIPPPLNGNAGGVGRHSTLPSNFQRGSSRLPSPYRHSNPHSHGPRRVSNEHHLHTPEGAAVASQPFPSASLPYAPPELLRAPPSGPSLAQDIWAVGIILHALLTGRLPFVDAFDPRLQMKILRGSWEVPQGLGKEWEECLVGCLDGDREARWTIKRIRESDAIVGWREVQSRSKSRSRSRAKGFGLGDRYLDPLGRNSSQPVPILSPNPRLRDISRSRDRSGQIEPPLSSSNYTPRDPFALLPQPNMPSVGRSRSVSASRSRSSGHRPMFALDGVELARGLESVELDRGRSARRDYDYASSSNSPYPPQRNTPSALAFARQQGTPSNQTPVPIPSSNNRSRSESANRAGHVWHPQSAPAQSGKFREAMATNFPAQGPRPVPTPQNDQRSHPNAKSRSRSRHSQTSQTSTSPSASRSLSRGGQAWTGERDGHGGVWEAAPERYAYGQELGAVHEEDRGRDRSTGLAIGQAERGVSRGRKGRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K635</accession>
    <name>A0A1E3K635_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035332.1">
        <property type="nucleotide sequence ID" value="XM_019172390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K635"/>
    <dbReference type="GeneID" id="30189420"/>
    <dbReference type="OrthoDB" id="2564497at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="49188" checksum="51FD7073D50F9CB7" modified="2017-01-18" version="1">MPNDDCPTAPAEYKIGWVNIHLPLIFDDGVKWIVRIPRRHNGDAPPNLHNLVASSEAATLRVLHQNGAKVPNAWMPVEGNPDEAANGRYFFEEFVEGVPYIDGDYMNTLHPDRDRFTASLLEFAQHYIAVADIKLEVKGIGSLYPSDNSCGYTLGPITSMGTFMRPEPPYFLGPFKTLRDRYIAHIEQVLFHIRNLSFLMIAPIRTYVWLMELQDIIKECEVLGREEDDFYIRHADDWFRQTMRDSEGHLTGCLDWEWAYTTTKSEAFSSPLHLHIAHPWTEGDNALSPDELLMIDCFIKLGRPDLGDCIRQGRLYLRLEEALRIDWELFYMNRRGNFNGVLAAFRDQGQQVPGPFESDEELKVWLESLEKKRQENGELDEVRATWRAYSAVWKEAERRDEETWEDVVAEQYKKLGLEEVDSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K660</accession>
    <name>A0A1E3K660_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035523.1">
        <property type="nucleotide sequence ID" value="XM_019172581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K660"/>
    <dbReference type="GeneID" id="30189613"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027262" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="481" mass="52363" checksum="0B411F03BE8935E3" modified="2017-01-18" version="1">MLLAALLLPLLPLAVALASPPQVFVNTAIARTLELAGATTHVTTQYNIKALVDAPGEYHLALAGDGDLIPAWWEVAIAGKAADGLAILSDRPPTVSVPLGHLKKDESITLSLAHVLDHQSRPLPAEIAQTDAQYLLFTTNSTYVDSWYPTDVERVKVRSPHVILTHGSVSDAYTRDNVITKAGTSLTLGPFHSLPATLGDAKVRQEPFTVHYENKESVIGITTLKRSAEVSHWGANLNIQDEISLANIGPKLKGHFSRLAHQMSRFHASSPAQILAELTLRTPPTAHSPYYYDTIGNVSTSHFRQGVTPAQTKLKSKGRSPRTVDGFLELKPRYPLLGGWNYSFTVGYDIPLGDVLKVDKASDKKVLAVPFLTGIKDVVVDDAEVTIVLPEGAVGIEIYTPFPADSISHSIHKTYLDTTGRPQITIKKARCTEQHAKNVYVTYHYPFSAQIQKPLAVASVVGSLFLLGIGLRRVNYSIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6B3</accession>
    <name>A0A1E3K6B3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035333.1">
        <property type="nucleotide sequence ID" value="XM_019172391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6B3"/>
    <dbReference type="GeneID" id="30189421"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="38435" checksum="CCEA858396643B29" modified="2017-01-18" version="1">MPAPSNRKGKSRATEEETVQAALPLGKQLAHTDKKVRDRAIAGLVAFVSQGSGEGEGSKYVPLEDKEMAKLWKGLFYCAPGFWMSDKPLVQQALATSLSDLLLLIAPSNPSDTFPAALAFLAGFWQAIVREWTGIDRLRMDKYYMLMRKYVNATFRLLAREQWKEEKVAAVNDVLMKKGGPVGWEDRSVPESLANHLSDIYLEELDKVLALPEVTSQPPCPVASLLTPHTILLARTPTKTVHTRLMSSLFTPILTSLSLASSTPVADSERPAKRTKKEEPMYAHIVMHSTAKEGGKERSTPEELKGSVLRGMFNAAAHGGATEPNRRKIYKVWREEGGDDDDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7L1</accession>
    <name>A0A1E3K7L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035698.1">
        <property type="nucleotide sequence ID" value="XM_019172756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7L1"/>
    <dbReference type="GeneID" id="30189789"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27867" checksum="C77FA06FBB774BF7" modified="2017-01-18" version="1">MSNIAAEIILHPKVNQTLAVLATTVGRDKVTRLLQYIARLLAWSLLHRGNVEEAARWNGLKGGLANGRKVMRLFRPAEFLQSAINLAQRPGPAQVAHIAQIGRQIGYAGFHTTDMITWLSSIRFLKYDKLKTDRIQRLMYKFWFAGVLSSLISSIASLLRLRADSRRFALSTEVAKREEKEGNLEAASKDAQRETIISQILSDSLDIWIPATGLGLANLSDGTLGLFGVVTSCMGVQAQWNKHSAAGVRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8Q6</accession>
    <name>A0A1E3K8Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035478.1">
        <property type="nucleotide sequence ID" value="XM_019172536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8Q6"/>
    <dbReference type="GeneID" id="30189568"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21297">
        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="115"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="392"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="514"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="640" mass="71009" checksum="D1C5E606A9713A94" modified="2017-01-18" version="1">MQAIKLGKKYPDLKQDEIFDLINKFKQIDVDDKGSLDKATVIASLQSSGDADYDSARETLKNVNVDSSGKVELEDWVQLHSLLKAAKTNPVLEHNKGRISVKGTAGTNAQHSMNEDERASFTDHINTSLAADRDIGHLLPIPTNTMQLFDEVRDGLILCKLINDSVPETIDERVLNKPAVKAGKARPLNAFQMTENNNIVITSAKGIGCSVVNIGPQDLIEGREHLILGLIWQVIRRGLLSKIDIKIHPELYRLLEDDETLEEFLRLPPDQILLRWFNYHLKAAGWHRRVENFSRDVSDAENYTVLLNQLKPDECSRAPLQTSDLHQRAEQVLQNADKIGCRRFLTPNSLVNGNPKLNLAFVANLFNTWPGLAPLEETEAPPPIEDFDAEGEREARVFTLWLNSLDVEPGVYNLFEDLKDGTILLQGFDKVIPGSVIWRRVSKPREGQELSRFKAVENTNYSVDLASANGMHMVGIQGSDIVDGTRTLVLGLVWQLMRLSINQTLASISKNGKGVTDQDIIKWANETVKSSGKSSAMRSFKDPSLSTAVFFLDLLNGVRPGIVDYSLVTPGTNEEEKRMNAKLAISIARKLGALIFLVPEGKSTGSSPDDTADSIVPDIVDVRPRLILTFVGALWSASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H8P9</accession>
    <name>A0A1E3H8P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000076">
        <property type="protein sequence ID" value="ODN72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027739.1">
        <property type="nucleotide sequence ID" value="XM_019180282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H8P9"/>
    <dbReference type="GeneID" id="30197527"/>
    <dbReference type="OrthoDB" id="5540949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="121"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="368" mass="42454" checksum="8B5E09754627C8F1" modified="2017-01-18" version="1">MDKNFRRNARMTKDSFIKLYHLVKDHPIFYNRSRNPQEDPAFQLYVCLVRLGRRGNGMSHGEVEEKCGVSPGTSLNYTLRTIEAINSVLSDRLSWPNTAERERLRRALGEKSLFGHCVGYVDGTLIELEYRPARTDQSTFYGRKNKYGFNVMAVCDINTRVLYLRTGFTAAVHDQRVLNSCQLVQEPLLFFSPREYIIADCGYTPSDNVIPSFKRTRGQALADNALSQMQTAFNSLVKRQRVVIEHCFGYIKVRFQSLKLLPCQLQSDDNHLNRVALWIRVCFLLHNFLLDEEGDEFWSDIDRPRFNQEAAAEAAEHVQVMAGAEARMTEGDRRGHGVRRMELVREIEELQGYGRNTIYDEGIFDDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF85</accession>
    <name>A0A1E3HF85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027870.1">
        <property type="nucleotide sequence ID" value="XM_019180144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF85"/>
    <dbReference type="GeneID" id="30197384"/>
    <dbReference type="OrthoDB" id="2564566at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="766" mass="85904" checksum="58D5915086BBD7B8" modified="2017-01-18" version="1">MPSRSRSLGAIFSEPGFAEVLEAIFHRLILRDTLALIRVNRNTRNVFKSSSHLQYTHLCRKHSSLPPSAAASRHPPSARLIKELAERERRLEEITPVGSSTYRLSSRVIAFEQGLIVAECDTKAPPLGFEDPPPEYMDPTGWEIIRVPNAELDKDSEMRGGIKRQDHWTWRTDYGGYCEAVACVEDNVAMVIKQWFHGETLSRVEFFFYQLLPPLGTPPPEDGNFDPIIHPDARIPCIQVVLPAAWPQSAELSHYKLCPEGRLAVQFEAGRDLYQKHPSGRGRNDLMNKEIFAVIWDWKAGVCLGQVPLFPDISTDFSGIYPVGPFCVTATHRKVPSLKHPELYESVVRPYTSFSTEADEDGYLTQFSLDFHTLLPLPLAFPPEHHSQDSTGTEPHTWRAGYIPYCLPLVSFDLPFEASAEFGTDVYSIWKDFYVVGARYKKELHNGDLRGLLLFTCHSVDAPTNVVDLNFVLRHLTKRLVEQAQACLSGAGLHLPLLSVFAMPTSTPDVSRLTRVEQTEWASSVLTMSTYANNLNMRGVWSPSSVIHSDMPELVPYLPEMSHIKLEDYPGTAEIRPASMEGCNPFSGEFGAREVKVIELGLEMEATGAIFVFTNYGGDAARVKPYAGPRPDDPQDPSTTLFHQSFGPKDNPNSITLNQSYDEEMETLSAEELGMVLPQGTPCLPQKSKTAMMWLEREGRWAYDPADWEHPAFVRFDGSSVIYDQTSVSVGRGRYDADRLAAFTVAYPQVLERDAPEDGDAQVRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ05</accession>
    <name>A0A1E3HJ05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_08108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027933.1">
        <property type="nucleotide sequence ID" value="XM_019180079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30197319"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="379"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142234" checksum="54FCF13A1514499B" modified="2017-01-18" version="1">MASPDFSAELEKVRRLAHSQLKHQAKPATLLQAIEHALTATLGTPQPHTPTAYFASLLQCLQKASNDEVGEDEDMAESENMGQGALIPATLYLLAIVVPETPNQVVLSSLSPVLECILPLYDGALEHPPALRSLLQITTSLILISPVQLLMSLPLLKKAWNYLLELNLDPRPKVRHQAQEGVRKVLVTPIPPRQTPGNHPYLPRAREWVMGVLEEEVKSGGGKGKKARFADAQEGDGKRGIQLVQGLRNWVAVWGEDHLSSLCAALLALPPLPHLTSQVYSLLAFLLTPPPSSSSASAPAPAPAVLSNLPTILDSLLASPPASSELPTYLSAITSALIKTSLQEPALLPTYLPKAHQLFFKDILLAPNAPPAVLAAAAASLGAEGMLRYCITDEMILATLTYMRQGSHVPGARKKSKTPFLFKFYESLVEAMNTNALRLPYFLTILTALISRLRLRVVPGSIPAIADPSGTGPAAAQELVMDLLKEVGDLRTERGFENKDKVDEVVGVAMDVIGVEAVLKVLPLNIEPDASGVPPQPGRAHLLPLIRHHTTNDSLSFFSTFFRPLSERLFNRKVAASDARREGEAKVWEVVVSQIWDCFPGFCEMPRDMGEGLDTQFLGLVTGLLYTQPTLLPALLKGLTNLVTSTERLIGSTTAPEELRKEFGLDQTIAQSNLTLLKSLAKDMISVLLNVFSKMPRESRGQVGDVISTWVGIMTPEDVVETYQTVTTHLSNNLDDSSVPAEGASPVAHTMLDLLIIFTPILPLAQSLALFTAVSQPTMLQHRDATVQKKSYRLLKRLLEGGKLSLSLTREKLEAFVGKLGESGSSVGPGAQRDRLQLLSALVTALPKDALHIIPEILSEAVLGTKEVNEKARDAGFELLVLMGHKMAEGGVLERGQQQVGDDEDMGVAGTVDANAEEYLTMVAAGLTGTTPHTISASINALSRLLFEFRSSISAETTSELLSTLCVFLASKNREIVKSALGFAKVSIVSLPVDALRPHLGQMVPALLGWVHDHKNHFKSKTIHIFERLLRRFGFDEVYAAAGATRVEEKKVLMGIKKRKDRAKRKRAGKDEGEEEEGEKPKATSGNAFDDILYNSDSDIDSEDDEEKDAGRPQKGKKGKKADGDLYIRNDEDEPMDLLSRSIAGASNPAKESRRRKPGEDASKFQTDKSGKLIIPADGPDDDERPSASASASADATAYLPNNTADGTHRDTRGNLKFNRNTKRAREEEKQMFEVFDEEDRIKAKVKERKKMRKTLGDEFKAKRAGGDIKRNDGPDPYSYVSLGQASGKKGGKASVNLTNKKKGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJC8</accession>
    <name>A0A1E3HJC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027975.1">
        <property type="nucleotide sequence ID" value="XM_019180028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJC8"/>
    <dbReference type="GeneID" id="30197266"/>
    <dbReference type="OrthoDB" id="2576456at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="770" mass="78944" checksum="F05F6A33F8BEFB8F" modified="2017-01-18" version="1">MLRGLPISKLIISLVVLGLARACWYYVYLESPYDYYYRYCNTGCAGLDQSEDDFKSCCMPFTSGQATPAVCTSLSSSCAAAGTTCSWGSVPTTDAPDTSTQVTDSAYTPPPYTPSTTAAASATSSCASSSDASSCAATSAQPGVVTETSWITSTTTTPCASSTSDAATPTTSEEACDCGDDSGETSDAGAATSSNWEGNTPPADFSADWRRRRGIMRRGACDCASSTFAAPSTTSAPPTTTTSAPATTSEEACDCGETGETSEAGAETSSNWEGNTAPAGFSADSRKRKRGVMRRGACDCPTSTSEAVPSTTEAPTTTDTPTTSEAAMPTTSETACDCGGETSDAGAATSSNWEGNTAPAGFSADSRRRRGIMRRGDCDCSSATDTPTTSEAPTTSDTPTTSEAAAPTTSDTACDCGGETSDAGAPTSSNWEGNTAPAGFSADGRRRRGIMRRDGCDCGSASETPTTSDTPTTSDASTPTSSDTSCDCGGENGDAGAETSSVWEGNTAPAGFSADSRRRRSKMGVMRRGDCDCSGQTSDAATSTDGGVASSSYAWEGNTAPAGFSGDNRKRFEPRNTAPAGFESDNRKRQYEGIVRGANVGGSENNKRNFNMVQGADTTTKDKRNVNMVQGDRSSAGGKRNFNMVHDKASSSNDEKRNFNMVAGGTRTVAERDLPTGFSRYYKRETATTTTMTSTTWITADGCGSATDSSASATDSASTSEATSDVAAGSTSSEMDSSSLPAETSATSSDDSAASPTTSEAASSSVWEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HKZ9</accession>
    <name>A0A1E3HKZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_08080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027953.1">
        <property type="nucleotide sequence ID" value="XM_019180052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HKZ9"/>
    <dbReference type="GeneID" id="30197291"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="186"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="510" mass="57009" checksum="34B234B6A4355199" modified="2017-01-18" version="1">MTLLSLFTTSHRSPGSPDQSLAPPFVRPPVAPSPHREFSPPSSNRHRTISHSEGDAENGGIHEDDVPLRYLRNSNRTSKRSEKDRPSPLLLRSGVGYPPDAPKRFPSPTDLSENTASTERSDFSPFPLSANPLLPHSAEETGEDDSQERIIHATDEALGDTEENTSLLPKENGDVGMSLMAKGSNGGARWCKKCDGWKPDRCHHCRQCDRCVLKMDHHCPWVGSCVGYHNYKSFLLFITYGTLLSIYSVFKTSYETYRFFSDPDAAVSHRRPSSSNSTSQEYSLIKALQNDIGLSPAVFMMLTILGVFIGLSVGALACFHWWLAAHNQTTLENITHSYPSALLDLPPPHSPSSPSPSSPQPRDRNTSSSRQPYQEPRLWKPDHMLTRRERERLRHDAKEINVYDLGWRKNLRRVFFGEGEVGAWGILAALWPRAGRSRDARAGHYFEFDAKAFEKLKGVTMELRYGVVKDELEDSDTEESEGEDEDGWEGGGDGVVASEDRDGGDRVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLT6</accession>
    <name>A0A1E3HLT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028007.1">
        <property type="nucleotide sequence ID" value="XM_019180008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLT6"/>
    <dbReference type="GeneID" id="30197246"/>
    <dbReference type="OrthoDB" id="10359550at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="60248" checksum="1C446BE9AB774E22" modified="2017-01-18" version="1">MLTTRLLKIAIPKAESSKQAQQRVAHMARCISSIKGKERETCRMSTFYCGDIPDEDIAPPSSFPPIISRLLSARLYRLATFHVVQTPSLAKDLALLESLSTHLEYNGAWRLAEGLRGISWKGGKARLGVTRRKGEEVGRIVERANQLGENRHQPPSSFWLGLENEAGLDDAASSGEQHALSRRISKRRSIPLSLASLPSEISKYLPPSFLYSSSCANEPEDHLLRLSHTLLAIISHQADFPSQGLDQRTKEVVVGLWIAYARGYLRGRRRNGEYTSEIEDGKEPGEGASGGVWGEKKGEGWDGREGSRAEGWDLPPTAETVMLLFRHISLLLAPPTIPSSHSSSSNLLPSLPITQSTQSTSPNIPSLPASTLLEPGQGTEKKKLLEEEGLEVDEEERRQQKEYEWDHLCRPLCRYTLRLLRLARSYHSRYPPVYQSPSEVGSMLAKPASSSASPSLLSAVSPPPPFSETALPLSAQHSPPPPPPSPFPSSPFSSSSPPTAPCLPQEIYLRRKAAWERQLAHQVGEYGKEVRGWMGARKGVLLGGSFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HTP5</accession>
    <name>A0A1E3HTP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028089.1">
        <property type="nucleotide sequence ID" value="XM_019179913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HTP5"/>
    <dbReference type="GeneID" id="30197146"/>
    <dbReference type="OrthoDB" id="2578052at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="460" mass="52693" checksum="686E9FD215B99F71" modified="2017-01-18" version="1">MPSSTTAAAQAKSVPKLNVVIRWIADPQQICRLLSIIKSNPLWRQACFPQGITTVPKLYKIYIDIFLVFCNNDPAIKAAEREGLVQRVKGSGGKKKWEATERFSSRVGNPVRRKIDSLKSALKSGTYTSTHNFRPSWKRWDDVPNGIRATLQAEHPYYFQLLELAQSSFQFVLPPRSANGEACQSGRKRELQPSLDVEDDRGPRVGNHKRPRIASPSLSYQAESVVEVDESGNDDTELPATRSSPPPSSAPLLSPRWNTDPQEICRLLSVIRSNYLWHQACFPQRGASASDNYKVYIEIFLRACRDDPVMEVAAREGLVKWLGGQSRWIATRKFDSRVENPVRTKTSSLMNDFVTGIYESDHGFHPSWKKWKDVCSTIRDDLQALCPYYFQLRSLVKPPLKVIRKCAPLPEEQQYQNRIDQKKEKKKKKKKKPVDINKAKDSKKKQREYSRRGRRNYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HTX2</accession>
    <name>A0A1E3HTX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028113.1">
        <property type="nucleotide sequence ID" value="XM_019179877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HTX2"/>
    <dbReference type="GeneID" id="30197107"/>
    <dbReference type="OrthoDB" id="10353469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21691" checksum="E4A90236B58BD127" modified="2017-01-18" version="1">MADTMEIDSLTFDRSMNLNNQEEDKENQRRYGGDSSDQEMSSDDSMGEDDMSHGGRQRGGRSTAPSPTNELPQPSFNNSQFTYTQGPSVTLLFSSNETGCTSRHDEQVIQSLTLFQSTPSEPAEEEETSVMDRYYSFNDYDVGHTISVHDAIGSQLEPATEKKASDLAKMVESALISLGGQSLVDDVTLDMRSGYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5N4</accession>
    <name>A0A1E3I5N4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028374.1">
        <property type="nucleotide sequence ID" value="XM_019179606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5N4"/>
    <dbReference type="GeneID" id="30196827"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="309" mass="35104" checksum="D40AE3A6967E071E" modified="2017-01-18" version="1">MTPQLKPESPPVGAVETGGDRELEERKHEFAYEVVQGLFIQNGPKPKHVKFEEQLKKSFGLIDESPERWQNLKSSVKDLQDAAPEGVSYKVFFLGRHGQGWHNLASDNFSKKEWEARIARTYPTADDLPWGPDPYLTPLGISQAQAINACWTAQAPLGAPVKQGEMVWYCSPFTRTGQTLMESWKGLVGDGSGVEVREDWRECYGLFVCDQRSTKSVIQERFPTFKIEPGFSEQDDLWKAEDRETEEHMQLRARRDLDRIFGAEGPEETYISITGHTAIFRNFLAVVGHQPYRLETGEMIPVVVKATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9L7</accession>
    <name>A0A1E3I9L7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028439.1">
        <property type="nucleotide sequence ID" value="XM_019179582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9L7"/>
    <dbReference type="GeneID" id="30196802"/>
    <dbReference type="OrthoDB" id="10289867at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="192" mass="20991" checksum="80102971086CE81B" modified="2017-01-18" version="1">MDSSSSLQKVHPLGVFPEQVTTRETTLIILGSLGWNCANFTVQDEQGREVMKGHPGGIKSSMTGEDGKVVYEIHRRLGFSKKICTVSSAGREIMEVVQKNMSFKTRMTATFTDAIAGDSRTLSLLGDWKAKNFGVKTEDGDEVACVKRSYRKHWGYHYALTVAEGVDLVLISALAVSLVVSSMEDEQAVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBB1</accession>
    <name>A0A1E3IBB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028572.1">
        <property type="nucleotide sequence ID" value="XM_019179431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBB1"/>
    <dbReference type="GeneID" id="30196642"/>
    <dbReference type="OrthoDB" id="2564557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="307" mass="34312" checksum="044DB4E1E7C7E3FC" modified="2017-01-18" version="1">MLLRRLYSACPHRHTLRHPPAPLPQTRGRTKPRLALPKPRSRHTTTLSKPLPAITAGRGRKPRLSFSSHSETSYPTVPEPVQAHIPRTPRLSYTHASPALNHTNEFTPIFLYPEQFKLHTAFTHPSHPLPLFNGTRGYTQSSPEEGENGGDIFMKPVAKAPKMGGGAMADHLNVVNSLPMASGQSEHGEVFGTPEMDGASITAFLENRAKDLARVNDSEWNKVMAMMDGKLLSVQAEKQEKKMELEKGISLDDVVGDLEGMLAKMQVSQGDEVHMDSVKRKRRKKISKHKHKKRRKATRALRKRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICJ7</accession>
    <name>A0A1E3ICJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028686.1">
        <property type="nucleotide sequence ID" value="XM_019179330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICJ7"/>
    <dbReference type="GeneID" id="30196538"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="566" mass="57643" checksum="8451928B906184D1" modified="2017-01-18" version="1">MAPSTKRPAPAPTPEHPPKHPRRDSDGRDERDDSPPLSFIAHSHQSIDGSAYGDPGAGVGVGVGGDDDARAKAARKEARTMRNRESAQRSRNQRKQHLVWLEKRVVELENENKALRASSPASPAPPAGAQSSSLSPSPSSSSGPRGQGGQAVKREASPAQSVISLATDLGLPTELVSGGSGVNLSSVAPPPKDLDLDLTPSAHALPCGVPTSPPPSRAEGEGEAEGEGSDDINVLLSQNRDLRERVGLLEGLVKQVVSLSSFSSFSSFSGVSGLAPLSQPDVPFPFPFPVSASGSGNDWPTLLPLPNMSTSGLQGIDYTSGAEGMGGMGVSPPLYTSVLPGTVLTPTSPSFPGLALTPSHPASTSPSPSPSSTSPSSSSSSSHLQPNPLPSSSSSQPQPKPLPPKKQDSDSDSSTKTKTKTKNTKNKSCSQPSPGACHSAVVWKHAFGSDESADLSVSSSTGSTATGSTGSTGSTGSTHDPASRFDFDVEADMALGGLDMGMGMDMEGGLDMEEGVKQWDLEMEMLLQDLEGRDTGLGLGLGLGLGGGLDGSVGVGAGLGTGGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IER6</accession>
    <name>A0A1E3IER6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028861.1">
        <property type="nucleotide sequence ID" value="XM_019179103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IER6"/>
    <dbReference type="GeneID" id="30196300"/>
    <dbReference type="OrthoDB" id="10303412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="74" mass="7752" checksum="3A3F14F8184C5522" modified="2017-01-18" version="1">MWGGYWAPFQSRYGGYGGYGSMMSPYFAGGLGTPFGMNALGYGMGAAINPAVYGISSMGIGNPYAYTGMYGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEW5</accession>
    <name>A0A1E3IEW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smooth muscle cell associated protein-1 isoform 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028907.1">
        <property type="nucleotide sequence ID" value="XM_019179149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEW5"/>
    <dbReference type="GeneID" id="30196346"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="786" mass="84219" checksum="4C5C533AF6E011C1" modified="2017-01-18" version="1">MAPHVDEGALQALLKSLSSAPATALAGPQVALIANALLPSSPRSARAIAYLCLSKLTTDLEDKGDSAAISKVFQPYVESIFRGPQPQIQEIDDESEAAEAGGEFDPEACVPATYLFLALYPLSPPTSTTLLTTKLEDNNDPLAVLLELAELPSPLQSALAQLFVAAADSKIGRDLTLSRGIEWLKGGLRYTEGSSEVGALCAAALSKLLGRDAEEKIPVGGEQEEERVTAEKGDQEQLARRMMSHVESGNSSTTAIQSTIEGLAVLSLQPRIRAVLASSQKFLKALVALSPVVNRKGGSLPVTPRGSMDADNFSKIFEAVETSFCYGLASILVNLTSRKPILSEQDAQIAKLRKMAVSADKRKLNEDDDDDDEGFETDGEVDKRVAAVLAAGVAPALSGLVRAESKLVKEQLGRLCRNLLDRGGSTEKNTEMIRARLAFVKGGGFKVLSIVVRDLLELATTVPKPPPSSAPTPAPPAIEIDILPACQAMAKLIITTNPVILFPAPMQTTSLNALTPLYHLLIHPDSLLIQRFEALMALTNIASIDPSIAAKLVKAEVKPLKVEAFLRSQPAGPVRVMVKIEEMMLDENVLARRAAVQLLCNIASCQSGFSYLSGEDSSSSPTRARSLLNILLVMACIDDIPTRSAAGGALAVLTESETACKYILMGDLKDEDGDSTPARSPWSRAVSLLEPPSDETYDDDGEPIPVISSSPPAPNPELVHRGVIILYNLLEYALTLGDEERTKEGVRVKEERVEEKLFGALGVVKKMGEEVVQPTVQCLRMIREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IF48</accession>
    <name>A0A1E3IF48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028729.1">
        <property type="nucleotide sequence ID" value="XM_019179248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IF48"/>
    <dbReference type="GeneID" id="30196451"/>
    <dbReference type="OrthoDB" id="2563978at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="823"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="979" mass="102983" checksum="24831FBF0C74C347" modified="2017-01-18" version="1">MGDADLDDSQLLGPRERLAENIRVLRGRLEERATGPGGQVLPEWITYVPYETTIDGVPITTGSLVELPLTYYGPSIPLAQGWTYGGSTSPASTASSASATSGQESLGSSSSSATTSSRSSARPSRSSDRSRSRSNTRTSTASEATTSVTSATDSASTSLARSSSGSVVSSSSSSPSSSSATLSSSLSSLTTQSSVNSTFPTATSTSTLGAAPTSSHRHLLAPLLATLIPFGLALLALLILLYLWRRKRPNKDVGFFPWLFTPKEWAAVPVVTSDKPSEKRKEGPPAAVPAGLRSPDEKSALLPDFIAQHPRNSSSISTIAPLPLPRPSTSAGEHDPEMKDLVQQNQSLLHRLTLGLGWAPTPSQRHSGSFEGVRRTSGNTAERGENPSSGVGMGGRMVSGAMAGALAAAGVFGVRKERSAAGLTTSSSGNETSGTGQKYERVLDEDQLFYRVPPQTSSSKGSNNDSSSRSRPSTGGGRWNRQQPALPEGSSSGHETRPSMTFSVSVPETPGSRHLSERDMDVAEFGRNIPIPQISPSKVRPVSGEREHMRFPIPPGLAFALKKQPRSKSSFADVGKDKDKDSRTSTETFYSALTGREPPAYSPESPPRPQGSPIHRDNEDYRHASVSVFGSVPATPVPAEWEGTGSSQSHTGQSDSQTGPLSRETSPHKSLYAPSPVSPALISTARRSQVTPVGDDAIRPMRRLFGLSPTPRSSTDSREPVSARGAEEGEGDDSWKGEPLIDERDLSTSGDGAGARGRERERGRRRMVGEFGQGLKSVPLAGASRTQQAPLPHSHQGSIHSSNLSSNPTSLSPAYPTTSSYQPSPLSPLAPKSPHSMKSHSSLAHSLSITSTSASVSASGSSSGHSVTHSTQGQGVRGKRSAALLVPAGAVAVIAGGGGVPPVPPVPAPAPVPMVVPAQEYNEKEKEKPIEEVEEKQELLEKTPKKEKEAKTKRWSPPKPVGPRPASGEKATIWGGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL5</accession>
    <name>A0A1E3IFL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028947.1">
        <property type="nucleotide sequence ID" value="XM_019179029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL5"/>
    <dbReference type="GeneID" id="30196222"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10813" checksum="ADE1666FC2BE62C1" modified="2017-01-18" version="1">MDESTANLDHDTDLAIQNVLRTALEDVQMLVIAHRLMTVCGLDKILVLDHGKVMQYGTPWELSQKQGGFFRDLCKQSGEEAQLREMAKSVHDKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGF8</accession>
    <name>A0A1E3IGF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029023.1">
        <property type="nucleotide sequence ID" value="XM_019178929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGF8"/>
    <dbReference type="GeneID" id="30196115"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="223" mass="25048" checksum="34F953C480BABD17" modified="2017-01-18" version="1">MSTGNTGTDITIDEVDYIDGQGTCFRIVGESTEVDEHGHPVAQYERIPLPDLMWWEGGGRGKSRRRITLSERSELDQWRVRAINSHRQATFRVRRKTRQQETDAERVESHIQAFGVAGAYEPSAASGEPSSSQQAGMTNEQMMQFYNSMTPEQLQYYGGYDTQYGGNSSMTLPSQQEMEIMGQVYGETMGNQPSSMASYNPELDDESALAQRFRELYGGRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHK2</accession>
    <name>A0A1E3IHK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029141.1">
        <property type="nucleotide sequence ID" value="XM_019178864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHK2"/>
    <dbReference type="GeneID" id="30196041"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="352" mass="37862" checksum="30ED5ACF82E26091" modified="2017-01-18" version="1">MAPVPKSGELSHKKASAGGSGKKKRSSGSAGGGSPTKKRKPPRRTRETLGCGPCRVSKRKCAGGSLFEVDCEECRSKGKPCVWGPPPDGWQPSIRMKLEAMVKEGRVSKDVLDMKGENQIAAEEAETKAAEGREDGEENVEDDGQGDGQGDGQGDNQDGGQDEKDAGEDQEDKDYGQEGGSEDGEGEEYFEEEDEGHEIGETHLQPASDDIDVRLPPLGHDSAPQRPPPYAFGYQPQTLLPALPTPPAPNLSLLSESPSPLAGLLYNHQGLHLPVIRDFYPIPYGHALGHQPPRMMPTQQPSISYQHAHRELFSRRNSGNILLSTPEYHFDGALSQFGGLSHMTSSSASMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3III9</accession>
    <name>A0A1E3III9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029213.1">
        <property type="nucleotide sequence ID" value="XM_019178730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3III9"/>
    <dbReference type="GeneID" id="30195887"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="51"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="293" mass="31400" checksum="F2DC294D1C8452AB" modified="2017-01-18" version="1">MSTAANPPTETSGAVNGNATDVFKRLHPAQYLSRFLASGYRPDGRSVSAWRDVSINVGSISTAHGSALVRIGDTTMVCGIKGEISEPLTNAPNDGFVVPNIDLPALSSPHFKPGPPGDEAQTFSNWLNDLLVSSKTIPQNKLLISPGKAAWVLYIDVVCINYDGNAFDAAVLAVMAALRNTRLPQARYDDDSGRTICSREETFPLTLGRIPLSASFGIFQSKYILPDPTSFETPLLPTSITIALDEGSQACLVRQEGLGGVEGKGGEGVLNEVWEVAEGRVRELRRILEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJQ3</accession>
    <name>A0A1E3IJQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MIPC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029378.1">
        <property type="nucleotide sequence ID" value="XM_019178677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJQ3"/>
    <dbReference type="GeneID" id="30195834"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="756" mass="84909" checksum="01DD43235B9D8AD4" modified="2017-01-18" version="1">MTFPSASSSRHPYQPYPSYSPGPRRRTSLSISLATTRPYNPYNAPTRRRARTMPQYARSRDHSHPISSKPSTRTKKVVISLLILLFLFLIGTVVVLSTVSYYLAIPTWAYLTESEVAWRPQDAIRPLRDVPKSSRRHKRAEWTEVGVGSEGSSASADAWTASAVGDVAFTLSAAPSSSAAASWDELEEEMEALDASEEDSVAEAETDASDALAVSVETTPSPTSSTPWGIDGAGSGGYWMEKDWDGYVRDTDSWERLYNVSNRAGERIPRLIHQTWKDDQLPEKWRKAWKECREGMPDYEYMLWTDDTSREFIATHYPAHLHMYDSYQYPIQRADSIRYFILHHFGGVYMDLDIGCRRRLDPLLQGDWDVILPLTKPVGISNDLIFSAKGSAFMDDTVHGLSAFNHRYLSNYPTVMFSTGPMFLSAQYAIFSSSHPLTTQHPRAEVRVLPKSLYGKNAPISDVPHSFFSHFYGSSWHADDAGFITFLGVWGKGLMWVGGAVILFGCARLVWLKRVAAKGQQYQLLSILPTTRSNSPTGYDTPTSTSSAPLSPTSLDRSLHQALPAEIASYFKRAGNLILAAPAMLQGDRPHARAHAHERDANRRGRRRQGLLYFVPALFQPVPARRSRTASEASQLPMRRTRRERERERERDLQRARESTHKSDGLAPPPYETLHEDPTFSDSRAGPSRPSASTSRFAQAGVPEGERYESFEKEVNMDEVDAFLNEADNEGSMSGSGSGSGGEEEWRDRARERRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKN6</accession>
    <name>A0A1E3IKN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029445.1">
        <property type="nucleotide sequence ID" value="XM_019178538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKN6"/>
    <dbReference type="GeneID" id="30195693"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="163" mass="17450" checksum="7C8049640CC3C582" modified="2017-01-18" version="1">MPSQVYFDIAINNAPAGRITFKLFDDVVPKTAENFRQLCTGAKGFGYAGSGFHRVIPQFMLQGGDFTNHNGTGGKSIYGARFADENFKLRHDRPFLLSMANAGPGTNGSQFFITTVVTSWLDGKHVVFGEVAQGQDLVKQIEGLGSDSGNPKAKVTISASGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILK2</accession>
    <name>A0A1E3ILK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029384.1">
        <property type="nucleotide sequence ID" value="XM_019178683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILK2"/>
    <dbReference type="GeneID" id="30195840"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000156">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="485"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN88826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="818" mass="91231" checksum="E6A28B2A1D7DC12F" modified="2017-01-18" version="1">MHHLYFASTSPHILLPTLRDILRLPDPFAIVSVDSEQIHTTSVIKRTLNPYWNENFDIEVKDSSIVAVQIFDQRKFKRKANQGFLGVINIKVSDVIDLELGGQEMLTKELKKGSDGQAVQGKLIVYLSTQTSGPAQSAAPGAAAGSNIATPSATANASSLNVSSAAAGISRPTSTVPAAAPASPAREAEVAAAVPPPAASPGSAPLVAPTTTAASTGQTGTNTTAGHEFDSHSDQYGPLPGGWERRIDHLGRQYYVDHNTRTTTWNRPSNDSVSNTATQATTTGEARARHNQRTLPDEMLDVQQSGGNTGTATPSHPPPGAEAPNNTSNATTAGQGPLPSGWEQRFTPEGRPYFVDHNTRTTTWVDPRRQQLLRFIAPGQQGNNLSAQPQTVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRNNTGQCHMKVSRENIFEGSYTEIMRQTPSDLKKRLMIKFEGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSGVNPEHLNYFKFIGRVVGLAIFHRRFLDAYFIVSFYKMILGKKIALPDLESVDAGLFRGLTWMLENDITGVIEDTFSITEEHFGEVVTVDLKEGGRDVEVTQDNKKDYVDLVTEYRISRRVSEQFQAFMSGFNELIPQELINVFDERELELLIGGMSEIDVDDWQKHTDYRGYNPSDEVVEWFWKCVRSWPPERKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVTQLPKSHTCFNRIDLPAYKSYDALEQKLTIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM57</accession>
    <name>A0A1E3IM57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029349.1">
        <property type="nucleotide sequence ID" value="XM_019178648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM57"/>
    <dbReference type="GeneID" id="30195805"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="243"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="628" mass="67614" checksum="3C320AAAF94A7467" modified="2017-01-18" version="1">MTDTQYTFRAQKTAGIVDAPAWDVSTRIPAETVGSKCYAYSPNGEWLAYASTNSVELIAPSSSSSTATTIEQPNVVAIKFSPQSTWIFTFERPVKTESGEMYKNGKAWDVKTGELAGSWYHKTLDDWEPIITADETYLFRPGPSDLAIFTPPFAARPATRLKLDGIRGVFISNPSALPEGSTNAKPIAAHTEPGVAIWVGEKKGAPASVGLWTLSALVGKGAANGDGEIKTETRDMPTTQARKAFYKADKLTVKWNNAGTMALFLAQSDVDATGKSYYGETNLYLVGLDGAFDGLVELDKEGPIYDFAWSPLSREFSVVYGYMPAKTQMFDLKARPVYSFGENPRNFVAYQPQGKLLLSAGFGNLAGGVDIWDVSTRRKVSEFKASNASHCEWSPDGRYILTATLSPRLRVDNGVKVWWCGGQLLHIQLTDELYQASFSPRLLKDLGPFPAVIPAAPEANPSVALLRPKGEVDGAAAKPAGAYRPPGARNRPEGAPASASASSATPMFRGGKPAGRYVPGTGPPGSAPKQVSGQNGNAKNDDKKRQRKRGGKEKEDEAPAPAAKEEVKEEAGEDATAKKVRNLIKKLKAIEELKTKLAGGEVLEKTQLKKIESEAQVKSEIKALGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMB6</accession>
    <name>A0A1E3IMB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029653.1">
        <property type="nucleotide sequence ID" value="XM_019178497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMB6"/>
    <dbReference type="GeneID" id="30195650"/>
    <dbReference type="OrthoDB" id="10310750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="41335" checksum="F652C842DB78E9A6" modified="2017-01-18" version="1">MSLITLDRLPSEVRSLIFECLQKTTHKPTLSSLMRVSRAMYAKSMPRLYERVRLNASNAEAYFGRLTADGLDAIDEEIALHKPHLIDYIWQLERENFELPPWASQFIPPPIARKICQIWSTQHLFLEDAPAAIFLQQAATSLEYLYGQLYDNTDGLVDDRDECMEWISASVLSDDASVALGEPLAKSLILYPKVWEGVAKMLKGNYFMDSLDSICLRIPANCSGTAVAQYCKDMSSRYIGTFCVHNVNPLEHMSLEVLHENLHIFLRPEGSPGMLSHEASIGAFMSNLLNIGKKSRSLVPNIHFYNSQYTDVDRVSHQSRGFWNELEEASNVPPDVSGFKFYWPVTLKLYGPEEEVACPNCLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMC8</accession>
    <name>A0A1E3IMC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029587.1">
        <property type="nucleotide sequence ID" value="XM_019178431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMC8"/>
    <dbReference type="GeneID" id="30195580"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="111"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="39452" checksum="75CEC03CE10F7DF1" modified="2017-01-18" version="1">MSNLIATKRVDLLAPYLALDQGDRIQAEYIWIDGDGGLRCKTTTVDKPPASVQDLKEWNFDGSSTNQAPGEASDVFLRPVAMFKDPFRGGKNILVLCECYDHDGSPNKSNYRAHCKKVMDAAKSTEPWFGLEQEYTLFDADGQIFGWPKNGFPGPQGPYYCGVGAGKVFARDFIEAHYRACLYAGVNISGINAEVMPSQWEFQIGPCEGIEMGDHLWMARFLLLRIGEEWGITPSLHPKPIKGDWNGAGCHSNFSTVAMRTPGKGMAAIEDAIKKLEKKHLEHIAVYGEDNDQRLTGKHETASMTSFSAGVANRGASIRIPRHVGVQGYGYLEDRRPASNIDPYRVTSIIVETTVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INJ9</accession>
    <name>A0A1E3INJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029684.1">
        <property type="nucleotide sequence ID" value="XM_019178246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INJ9"/>
    <dbReference type="GeneID" id="30195392"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="808"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="901" mass="98892" checksum="FB8037A3A91E066C" modified="2017-01-18" version="1">MPGSGSDSDPSQPPRKTLHRAQGQLKRNAACQECRRRRVKCDAARPTCQSCIRSYHFLSRTYPDAERDAKGVQCHYGDEDYNTDRPQEPIIPPRPPKRKAGTAKGEAEQKIKLLEDKVVQLQKALEQSSPSKSPSVALENTSPGQPQTAAKESALPTNRPTPLWSEAQGTTPFPASANSTWSLNTAPANPYDLSQSFPDPQHFSVLKPADGRGSVKHRLDHFEQSLDPPAADAEAGRLGPAVLDMLWPGWPPTLPTPSMVDHLAEVFFKFVPSISRVINRQSFFARLSLPPTHSEFPQRALIHAICAVAARYTAAVSVRSVADSMKIVTEEAKRANGRGAETDLSMETCFAERNAGYAMEFMKYNHMNARGIFDILQAMIVMGHWGQAHSRWMEGWVLMGGATRLVIALGLLEHTPLSQHLSPPVSRSILGPPKTDAEREERRAAAYYVMIYDTTQSASSGWAGTLPTAEMSARMPASKADFERGGAIPENFQSFHSRDLFYNHPIVDSFVLLVKGHVLLHRTCQFIRRCRAMDPDERELLRDGPEFRQLDRDIAMLSMSFPQALKEPVQYMTGYAKGVDADLISAHLIPRMAAMYLHEPFAHLDDPNSVSATRVLTEARACLDIVYLVISSNADISFTVTPITSLYLFTASRALLLFYQRALDTGDSAEATTIHGEISVFKMAFTSLSSRFAMGVRHLILLEKMMEHIEEDVLGQVVTSPDFSALFCRPSRAFPNGITNVDSATGQIPGIRGQDEIPGFASLGGEAVFPETHPDGMIAIELDRSAAQGRSKAGRKVLQAILDHKRNYVGHSSRSNSGSGSQPGSGGPSPNDAFEWLDKQQGMGQVPMQGQGQGMGAGYHPGPSHVQQPHMNTASSTGSDMMYVQSQSSMQGQGRFTMFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INK8</accession>
    <name>A0A1E3INK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029712.1">
        <property type="nucleotide sequence ID" value="XM_019178274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INK8"/>
    <dbReference type="GeneID" id="30195420"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="502" mass="54271" checksum="FD55A773CA37FEF7" modified="2017-01-18" version="1">MVHTQNTPVATSSTPLLAPAEYSSSNPAPIPWRLLVPILLIRIVDSISYILVFPFITEFITSLHAPPDKVGLYAGLAEGCLMAVEAFCATRWARAADRWGRKRCLVWGVLVTGTGCALVGFGQSVGWIIFWRAFYGLTPAGVLTRTVVAEISHSSNRSRIFAIYSPMLSLGVIIGNLIGGELAKPYGKLPWWMGGSMKIWQHFPYALPCVVCSILSLSVVVLCWYTLEETKKSPEKDQDENAQGEARETNTFKAVLQVPHFMLVMGILCTSFAFEGLFTVFLWTPIKRGGLGLPVHFIGLTNSLSSAIYILVSPVLAPLIEDKFGLKGGLALTSGAMPLEALVIPLAQFAATKGLAWTGVMLGVQCLLKNFHCMGWSQGDNIIFAVVGAYPELTASASAIQCIAGAIGRASGPVISGWVFSFSTAFPAVSLGRQLSWIVLFLICLPPLLLVTVIPRLTEDGKDDESQVEVVKENKVEYEVVGAYTVAEGYYGATGVELVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ96</accession>
    <name>A0A1E3IQ96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029879.1">
        <property type="nucleotide sequence ID" value="XM_019178160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ96"/>
    <dbReference type="GeneID" id="30195306"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000133">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="295"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="567"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="793" mass="85917" checksum="CCCEBBF00041905A" modified="2017-01-18" version="1">MTPLASLKAIPAQDTVPGVITREARRAYLAPVFLKSQKIVAGDWLLFKSDNGSTVAQAWPKPGISEDSVGFCPVQMDNLAGPKVEAYRFKAGQSQGRIVSVTVKEIPIVDAPSSSKGKTTPVDLNSPREQVWCKAAVKEALTSIYYVRSGYSVIVGDAEKVPRKFQITSVEISAKDIEKRKAASLEDALLDLKIGGEEVQVCEMHWKTAIILDGEEKAGQGVVKGEKDGKITTKGSSKQFSDSVPSYINLFTPSQSPDSAYTFLGGLQSQIDQIKTLLDLPMLHPELYIKFGLNPPRGILLHGPPGTGKTALARAVASSAGCSCIVVNGPELTSAYHGETEERLRGVFTEARKRSPCIVVLDEVDALCPRRDGGDGGEVERRVVATLLTLMDGMSHESLAGERVFVVAATNRPNSIDPALRRPGRFDREIEIGVPDANGRREILNIMLSKIPHSLTEPELASLASRTHGYVGADLFSLVRESASSAIARYSSTPLPSRSADPLLTNTDILTTLPSIRPSAMREVFIETPSVKWDDIGGQGEVKQKLKECIEWPLTHRETFMRLGVEAPRGVLLYGPPGCSKTMTAKALATESGINFIAVKGPELLNKYVGESERAVREIFRKARAAAPSIDEIDALGSARGEDTNHSGVLTSLLNEMDGVEELSGVTVVAATNRPDVLDSALMRPGRLDRILYVGAPDRETREDIFRIRLSKMAVEPGVDVGNLAMLTEGCSGAEVVSICQDAALSAMNEDLNAPFVKGIHLTQSAMTVRRRITPDMMRFFEEWRDQSGVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ97</accession>
    <name>A0A1E3IQ97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029876.1">
        <property type="nucleotide sequence ID" value="XM_019178157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ97"/>
    <dbReference type="GeneID" id="30195303"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="26498" checksum="26583CEAAC4F69C8" modified="2017-01-18" version="1">MTTPTPVWKPDASYERRDMPPTDGGEPSSGPTAGQVDAYLAPKLLHPSYGADPALPAIQSRALEAGIPAISVSPLQGQFLSILALSIGAERILEVGTLAGYSTAFLSLALPGHGQIDTLELDPHHAAVAQENFLNADLFPFPKIHVGPALETLKRLKKPAEGAYDLVFIDADKEGTLGYVKEGLRLLRKGGVVVVDNAVRSGKIALSREEEPSPNVDGMRRLFDWIEEDGGRTVLANVTQTVGAKSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS98</accession>
    <name>A0A1E3IS98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030034.1">
        <property type="nucleotide sequence ID" value="XM_019177995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS98"/>
    <dbReference type="GeneID" id="30195134"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN91408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="46289" checksum="0D54BC2C71DE430E" modified="2017-01-18" version="1">MPIPTPQQPLRIAISGGGPAGLAAAIALRELPGVEVTIYEQATVLREIGGGIRIGYNSWKVLELLGVADKVTGHIKVDHRHMNGVTGEMVYKYPPHDGEFKYHDIRARRTVLQAALRSKVPDEVIKLQKKVQKVEQLPTGGVKLTFKDGTEAAADLVIGADGLRSAVRTQTWGQHKTFWNGTTIFRCLIPLPFVDHLSISKYTAFHHGPARMFKVSVVSTKEEIEAGKGQWELTLRVFEDPKEVTAPKFSWGIPCTNERVAGYFTKFTPEIREAIDLVPEGSWKEFSAFSGPRLEHVVANGNTLLIGDASHPLLGAFGSGAGFAMEDGYLIAQILHHYLPSPSSSSSSTEERTQALSKSLALFDKIRSPYYAKMYQVLDQPKNIENGKDFGSFSPTPGNPLGWIYGHDIGREWEEIKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU97</accession>
    <name>A0A1E3IU97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030262.1">
        <property type="nucleotide sequence ID" value="XM_019177878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU97"/>
    <dbReference type="GeneID" id="30195012"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="617" mass="69020" checksum="34E7130C4E6434FD" modified="2017-01-18" version="1">MSATESQPRTSTLVIGGGPAGLVGLKYAVQYGTAWAQGERPYLVEMEPEIGGTFRWRGYENAELVSSKQLTCFSDFRYPLEAPDHPSLPNFVQYLNDYVKHFDIEQYIHTSIKLISLEHTDDDIYKHRAVLQPLTQDKLPKGEPFTILAERVIITTGLHVIPNIPAIPGLNAVPCTPEPPKWIHSSDYKSRSQLKGKKVLVLGCGETGMDVGYEAIMGGAEKVWLSVRSGMLSFPKVLNNFRLFGTTFDGNLPIDGLITNLFETAYVHPWVSASHVRWFISDLVIKRVLWFLTGTQAGCNQWAGELPPERQGRAYVFLNKSAKAMQFINQPFYKLSPLHQYFAHYIDPPSPPGNPKIDIVTFPKAFDDEGQAIFPPPPPHRSKETAWREECKPDLVVLCTGYTQDWSWLGEGYPKGPDECEIRGVTSGKDLSVAFIGFVRPGVAGAIPPIAEMQAQLFTSLNQGRIPIPMSPENYHLLHAPISRIQYGVDHSTYMSTLAADLGSQPGLFTLWWEYGWFVVFVYCFGAAFSTFYRLEGPYKTESAKGIVETELWETIRRRGLVGNIFMGVIPMLFYALLNGLAFVLGLVWDLAAPVFGLPPAPMDLFPQKEVMKAKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUB4</accession>
    <name>A0A1E3IUB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spermine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030169.1">
        <property type="nucleotide sequence ID" value="XM_019177785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUB4"/>
    <dbReference type="GeneID" id="30194919"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="558" mass="61575" checksum="332EC1C11D3E55FF" modified="2017-01-18" version="1">MLEPVEAEFAKPPIYNDAQEEVFQSEETEEPNAITHAANNLTRVETREGRQASPTHSQSSTLQNNRVAAKLDDPEKGGYQKTADGKILVTFDVGEDPKEWTKFHKLATITASTLCLTVALGSAMPTGDLPGAAEGLHVSDEVIYLTITLFVAGFGIGPLFFAPLSELYGRQPVYMVSIIFYFFFTLPSCLAKNVATTLAGRMIAGIASSAPFTNVGGTIADVWAVQDRGIPMAIYSSTLFMGPCLGPLFGGWISLKTGTWRWIYWVLFITIGASCILCLFNPETLAPVLLRKKAKKLNKQHNTDAYTTEADLHRPSFRTAITTALIRPFVMMVEPIIILFTFYLSFVYALLYATFFAFPIAFEEIRGWNMGMTGVSFVSIIASFFILLRTEADSLPQIGIFLANVLIMPLQERLYRKYTAKHGSSPEGRLYTMMIGAIVLPPALFILAFTSYPGVSWVGPCICGIMFGFAMVSIYISGNSYIVDSYSNVAASAISSKNMIRSFVGASVPLWITQLFHNLGFQYAGLFLALVSVILMPIPFFFFWKGAWVRSKSDKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVZ1</accession>
    <name>A0A1E3IVZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030210.1">
        <property type="nucleotide sequence ID" value="XM_019177826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVZ1"/>
    <dbReference type="GeneID" id="30194960"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129968" evidence="6">
        <location>
            <begin position="22"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="877" mass="92611" checksum="4D13FB56B73C66EF" modified="2017-01-18" version="1">MFAIPLLSLLPLLLIPLSATANPRPLNHPHNIDHPHRRALKRSITSDASSVNGESFDFVIAGGGVAGLTLAARLSEWSNVTVLCIEAGGDGTDVEDKIDIPGYSYLNSLTGSAYDWSYNTVAQTDNNDRIMYWPRGKGLGGSGAINGMFWGKAAMEEYDAWATLNPSGNETWNWEEMDKYMKKSENYTAPSSDVKSKFGLVVNASAHGDSGPIQAGYTEYIFDEVAKWIPAWETLGLSALDLAGGSTHGAQLSTSTINTSNQTRSDAKAGYIDPLPPRDNLVILTKQQVTSVVFNGSTDASGNIIASGVTFQSAKGETSYSVQANKEVLVAGGTVGSPQILQLSGVGPKTLLSNLDIDVNLDLPVGYNLQDHISYSMYWSTPQGTLTWNNLSTSDTLQASELAEYKSSQTGMWTYVNEAVGYPSMADIMDSDSAASTYADDVSDKISDTVSDVTSWLDLPDNVATGLTAQYKIQQEWLTGDIGQLEIILTMLGNGGNEMGIQVALQHPFSRGTILINSTDPFTQPHINPDYFGVGFDIDIIGYGSEFARRLAAASPLSDVMIKETAPGSTVTGDTLANYTKNNAGTEYHPVGTCSMLPKDSGGVVDTTLTVYGSANLRVIDTSIVPLELSTHTMATTYGIAEKAADIIKKKHWVVTAADETTSAAAVASTATAGKATDTAVTGSTNQDSADSSSSTLSTGAKIGIGIGAGVGAAAVLAGLLVFCLAKKRKNKKVDEKGWYGDRAGGWNEQGGAETPYKAAGPAYPMAAFNSHDPYDSPTPGFVGHSRNDSFNTIATADLASRTPMRNSSSFSYGGAGLGPDNGAGPYRDHDVMSDDGGHGHQGQGHVYQPPGAGGHTAVAPGQQQWGSQVYHPVNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY72</accession>
    <name>A0A1E3IY72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030603.1">
        <property type="nucleotide sequence ID" value="XM_019177450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY72"/>
    <dbReference type="GeneID" id="30194576"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="11916" checksum="8087E3A4EF3E4660" modified="2017-01-18" version="1">MTLGQSDSEAAKQHIKPDIFNVTGNTHGHGHDAFRQDTSGVTNALKPSGKQSLGDQAEQLVDRAQAGAQPNDTKSVTQQTRDYVTPGNDSAGAGGILNQIKNKITGNEHKGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYF0</accession>
    <name>A0A1E3IYF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030673.1">
        <property type="nucleotide sequence ID" value="XM_019177520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYF0"/>
    <dbReference type="GeneID" id="30194648"/>
    <dbReference type="OrthoDB" id="10281052at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="409" mass="46933" checksum="BE42293E478A99E1" modified="2017-01-18" version="1">MLLRNRQYTANPPNKISKKRSTATHPQEEDVPTSPLPSFFTRLPPEIGAIIYDHIKLSASKSDIINLCCTSETTYLTFVSVLYESVRLSDRNVRAFFGDLCNDRPVSILCPRPGMDADVLQRCLPLISSRLLRKFITFNPYIQLVTLGFESPSPELLQSTSCLFKKILLCRFIKTIIIEDLAACHFFRHFSDLVYKRFRRFPFYEPEESVYPAIEFGFEHVEWLVFSKSFTEDVEKQWNDGGAAMRTERWYWAEVTVRHVAPRRVCAWAFTDDRAHMVSELGVGWTSNRPQLKQFVLHNAHFCTELFPLPAEHIEYYLQPEKAGCSHVQSISNGLPYMFSVPGTDRHHDIHGIRRLEIHNASITQQQVVDILARSHDSASKDWSQWKGTLVVDGKGLPAKSCDGCELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYG1</accession>
    <name>A0A1E3IYG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030570.1">
        <property type="nucleotide sequence ID" value="XM_019177417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYG1"/>
    <dbReference type="GeneID" id="30194543"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="659"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="734" mass="82098" checksum="D9AC979AAFC705CC" modified="2017-01-18" version="1">MGRKKSGKSSLSASKPTAAPGARINRMEIYEDTLEPGSVDDFMFKRDQISFNPQDESEDEDINEDEGEEVLSLEGARRRAREEQEEEYDEDEEEQPAPVKKGRKEKVKVDASTQGRYGKPIVSSDEEEEESSGSSDSEDENWGRQYYSKPSNRREKEKEGEFGDEKREEERDMEEREVKRLQKKQREVLGGDDFGMEDLEEQPLVSEVSQDVLDSLSVAAPAAPKTADGPALLRHLQAHEPLKLALTRDFPLVVQKLEKTARGIKKMEETPEHEAELHKGLGWLHYQTLLTYATTLAFYIHLESLPASDRPDIPIIPRLFQLKQGVTMLEDLDFDAASSSGESLVLFDRFGDLDNWLESGDDELKEGKLELIKRMQAVNGDGELVGLEDDEEAEDDLWQNEGLDEDELAELLQDAGEDAEDIKALAAKDIKALAAKSSKKKKEKKSKKSKKSAEEVDFAALLEEGEKPKKSKKTKDSEVSSSTPAFAPLAEPDFFPSKKSKSKSNSDNSDVLGDPTALTDADYTDKQSRKRSLAFHTSKINSTLARRAEGRAKRMGGDDDLPYRDKRKARDAALRKNGPSAEGEDLEDISAGAEKTKKRARDEDAGDGEGDGEANEADGYYELVKRRRREEKDAKQAEHDAAEAELLAERAAYDDESADGPRTITRAIEKNRGLTPRRTKTGRNPRVKKRQAYDKAQKKVASQRSVYKGGQSAYGGEYKGEKTGITQVVKSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J062</accession>
    <name>A0A1E3J062_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030733.1">
        <property type="nucleotide sequence ID" value="XM_019177152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J062"/>
    <dbReference type="GeneID" id="30194266"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="78317" checksum="F680AD439EBF3C0A" modified="2017-01-18" version="1">MSLDPSQANHSRPVAPRHRKRLSSSISPRTFPTTAREARETTPSPMFGDATGSLAPNGDGGNALVLSELRQRSESVLNRAGREDVEWALREEWETREKLEKRLGSLEGEMGALEATNAELERALAVVQARTDEAFNEQARMEADLEERDRLLDRLRKRVSDTERQLKDSQGRNADQEKAFETERHALQAQEEHLQKRLNTALSAARKTRPPSPTPAHSDTAFSTSNLKEELATLRLSKSTLEAKFSTVLREVSELREENRELKEENEGWEFMVRQKTLNGHIMNDGGFLGMDADGADAGRAQDDDALVRDTLDPHSPIKSRKSVREASTGQAGGGSHLAAEIGRAQETRELGVVEEGDEDEALRNEVKHLREAHKALSLYCSKIIDRIIAQEGFEQILSVDYKTRRVGSRNVSASQTPLKEIAISLADSSVNTNLPPSVPLSEERVREAAERKTRPMSMFRAFSSSTDRIVEEPKPLPPPVEVPVPAPEAKAEKRARRGFSLDFRSLGFGGAATPDPPKPALRPLTLSSRATSATPPSEKDKGKKDTMLPPPLSATARKLEPQEEDEDDKRERHRMEASLKLMGIQPGNVEATSPGPMTAVERRSPWSRLYSVIGTPDPEPLSHRPGADAKDAEVALKEFHQLEAERIRALQQGKAEPRYTTPPKVGLHRRQSSSEAGARDRAMSGGSMRTLWSLGSSRPASQEIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0A9</accession>
    <name>A0A1E3J0A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030841.1">
        <property type="nucleotide sequence ID" value="XM_019177260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0A9"/>
    <dbReference type="GeneID" id="30194379"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="287" mass="32378" checksum="B5A30676AA6AF7EE" modified="2017-01-18" version="1">MSRPEEISPPELFYGDTEAAKYTANTRIKNVQSQMTDRALQLLALPEGESSYVLDIGCGSGLSGELLDEDGHVWVGVDIAPSMLEVALEREVEGDLFLHDIGQGFGFRPGTFDGAISISVIQWLLNADSSSHSPPQRLNRFFTTLHACLRNPSRAVFQFYPNSDDQVTMITTAAQRAGFGGGLVVDYPNSRKVRKMYLCLMVGQQEIPKALDGDDMNVDEETMEQRRAQVKNQAKRRRESRRKSKKGKKDLKAKEWVMKKKDLYRTRGKEGVPTDSKYTARKRKTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0E1</accession>
    <name>A0A1E3J0E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030878.1">
        <property type="nucleotide sequence ID" value="XM_019177297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0E1"/>
    <dbReference type="GeneID" id="30194417"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000007">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000275">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="598"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="796" mass="86887" checksum="9D593E3B07A03867" modified="2017-01-18" version="1">MGHSSSQLPHTRNKTSSRSPVKSVSASGFTVKPEDWKRSPSSRIQYPHPPQTGGVTETIFGIEVNDPWRALEDLESDETKAFVKAQNKLSIPRLSEHPLRKPLEEAVAACYNHEQMSNPELQGDGYYYWKFNPGTAPRDVIVRSRDVSEHFGKAPGSEGPDLFYDLNKEEKVSLYADSFSPSGRLWCAVLQYSGSDWQRLRIIDTRTKEVLERDLGGSKFTFGVTWVGEKGFIYKRSVIYDPSNDSYDGIDGAFGMFYHAVGQPQSTDVLIWGPPDGVFQYIGKTKVISVNEQEGSGERAWLALDVYRNTSPETELLVIELPGGTANPVGSTIAELVVKEGKWLSRGFTGETHYIGSLSSGRHLFTSFTDGHSTGRIIAFDSAEWETTPIGSNVPLHEIIPDDPSGYQLGSAHVIGDQVIALIYLKHACASVVFVDARTGKLLGAADAEGTHGEVVAAPDTHIPVPEEEISRASEGTVVIPEHGAITSVSAGPYASDFYFTVDTWVAPSYVLKGAIIKNKAGSLEVDISNVRPVDDPAPHETLISSQIFYDSHDGTRIPMFICHPQDLDLSKPHPLLLHAYGGFCVPVLSHYDPMFATFMRNMRGIVAIAGIRGGGEYGTAWHQAAIGVKRSVSWDDFASAAIHLQSIGLTTPSLTAIYGSSNGGLLMSASTIRHPELSEVVFVDVALTDLVRYHKFGLGRMWMDEYGSPDDSNDFSILLATSPLHNVNPDPSVKYPAMLITTGDHDNRVMPGHSLKFIAELQVGTKSTAKKVEEAVDRLVFALDNLRSGDISGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0V0</accession>
    <name>A0A1E3J0V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_05141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030816.1">
        <property type="nucleotide sequence ID" value="XM_019177235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0V0"/>
    <dbReference type="GeneID" id="30194354"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="66"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="263" mass="29841" checksum="93CC1173B0F374A7" modified="2017-01-18" version="1">MSTAVQTETATVPASLQLADVSLDTYDEEQVRLMEERCILVTPDDVVYGDSSKKVCHLMTNINKGLLHRAFSVFLFRPSDGRLLLQKRADEKITFPSMWTNTCCSHPLSIKSELIEEDQAGAKNAAIRKLPQELGIPESQLKYEDFVFLTRIHYLAPSDGIWGEHEIDYILFSTINVDHEANPNEVSDARYVSKSELEDMFADPSNSFTPWFRLIARDLLFPWWDEMFAKSKAAGWDAEKGVGEVRADHLANGPQVNELIRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J102</accession>
    <name>A0A1E3J102_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030866.1">
        <property type="nucleotide sequence ID" value="XM_019177285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J102"/>
    <dbReference type="GeneID" id="30194405"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="70444" checksum="4465795C166FA0DE" modified="2017-01-18" version="1">MITPTPAHGSNSYRLVRGTKLADIPPQPPLPPVPPLSDLDGPFQLAEYLSLKVRHDPHDVKGLVEVPGGDESVGGKGPDRNVWIYEHLRRIPIDLTPLITALLPVCNRDTCGPEMRGQDFTYFCVAHGNGTRECSSLDYILHTLDWTVALLNNPTHFPSRMQIPSASLSHFPSMFRRLSRIFSHAYFYHREAFELAESENSLYARFAGLCEAYELVGKDLLQIPNPNEHIGKPSTDQEKEEEKEKDLRGDGKKERKLFDFGSEPEKEKDEEIEESEDFRHPSPFTPSTSPLPKKKLTTRGTLSRGKAPRTSMLWAHDAPEAEASSTSIPDTPIPESKDGQEASRKRSDSLGSTTSVVTAVHDTESEHPSEEIVEAAETPADTIIETPAAAVDPSGPSEPVSLPDPADLNINETTPPALTEQEDPIDEEARKDEIDLLEETGELPRAESSVAPLPPPTKSEEEEQAPTPVKQGHIEASDESGQLVDEESGEKVEDDEGMEDVVLDDEKKGMEDDVKAEVEDEEKSEEAEGEKVEPATVTPRPEPVGDLITGEVGPDDVPEPAPGSKNDSTEPEPTASPALGSSEELSPPLTPNSEGSEGSDRQDATSSGSGSGAEGDKKGSVSKKTKKKAAQKARQKKRAAEAAADGAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1G5</accession>
    <name>A0A1E3J1G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_04855</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030992.1">
        <property type="nucleotide sequence ID" value="XM_019176960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1G5"/>
    <dbReference type="GeneID" id="30194068"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14 19 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="769"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="535"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODN94713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="943" mass="105470" checksum="5DA2D09CE8CFCF6D" modified="2017-01-18" version="1">MNADLKRVRENTLDDSPAPSAKRRLNSHAPSPVPTSASDDDGMADWMKIVEIKRKEAIYRQMLEYRRSSEREAQRANDLEAQRRVLEASFQAVEVCWTQIVTAVRDLAGAQEVELQEEQVLEPLLDPSLPQPELEKALQSRLPTTRQLIARFIDLIARNATRPASEADLQARCLKLEAEASTLRGNFTLLHSQISDLTESRDGVQKDLARTRKALDRERMEHEKAHEEWKEERSQVGRSTPGLRTNGSGHATPNGHVDMDEKVLNGAGPSASGALQDTSELEHLADSRLKQLDQLRAEQTVLQQEVDRLKILATHPSESAVRESPFFQVYLNQLSTQLSRANALQERFSATEAKLDQLRDANGDFREAVLAEARAETEALRSQMAKKDADLARLRGQRDEMNAEIMERRAKEAEKCRFTEQMEGLASTREERIGFLTSEVRRLKGKLAAEHGSEGYLSFLRDSGVDGDYIQDLESKVSTSQDQVNALTSQLERVSSDHAAAISEVQVRAELEGARRALARYERILGPNVDAVDDVQYLATELEKKEKERAGLEMKLAEAEAATNALYEEVEGLSKLWESLDQTVKSKVLELRDGEQKITRLATEKAKADNKYFAAMRAKEAVDVEAKTAQRSVEKQLRLLERAQEVETSLRLQISINEKGMTSLKNSALDLQTQLATAVAERTQLELRLQQSQSAYTEAQQIMQARVQEAVQEKEAKARLQDEVDGQGRQIKKLKERQESVATAAQTGMSNNEWAITQERDKLLKLLKCSCCEQNFKQQVIVKCMHTFCKQCLESRIASRQRKCPACGLAFAKEDIQTLYWQIGGFAACFVGGLAVSLLGAILLFLGATGAFAVLFALGGVISLVGTGFLVGFKTQLEKMFKPVRVVATVLLFAAIIMTFVSAFVLPTVLCIIFVIVQYLAYLWYTLSYIPYARTAVKSAIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1M2</accession>
    <name>A0A1E3J1M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031059.1">
        <property type="nucleotide sequence ID" value="XM_019177027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1M2"/>
    <dbReference type="GeneID" id="30194137"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="211" mass="24031" checksum="4BBE83CB48AC598B" modified="2017-01-18" version="1">MTHSACSLKWPASSSTSYKNHETDLSPRIILGLWHPLFIRPAVKDLPACRRFYIGFSIQIANKQHFWDTCEGFSISFPFLMGQEEQAFVKECREKGKEVTAWTVNDESEMKAALSMGLKVVLTDKVGVFANLKHEIAKNPESLQLQGLERWTFPWSNWKYYSAGQRWILRTRVQQLQNLCYQPGPLTLPDLSDLDTDTGEDRSSQKGGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1R2</accession>
    <name>A0A1E3J1R2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031086.1">
        <property type="nucleotide sequence ID" value="XM_019177054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1R2"/>
    <dbReference type="GeneID" id="30194167"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="999" mass="108101" checksum="47CEC8409CE94560" modified="2017-01-18" version="1">MDVLRPGHAHRSSSDRLLNNYLQKSLSTSLLTLLSHSHSSTSSLLAYVTSSPGVIPTIRRSVRHAAFEGPLSSGMTEGSQLGSEGEGGWAAYISSLDQFRKDLKQIHLLEEEISRVKRDREILVGRLIKATKGRPTKSDLSALATTYNAQFDDPRSSRASVMSDSSSNTKAGKREGKLADAQAELLGCEEHLRGLEVRIEAERNKVMARGLEQRFRAMEVVGRMWVQQAKRGLSDLDRMQDLPPDAFELDSNGSLAPSQSASQVAYDDVPRPHPLGGAPYPRHLQPEFAGSIDGSIAEENEDSSDEDMDGLQVHENHPGQQLSPRVPPKGREQSHPSGVPSIIDYSPKLGNRRAASDIGTGAYRPTPPRQSLLRTVSHDRGTSRQSRRAGSDTSSIREHKPKKKGFFTSIRTWFKGGKHHGERSSSPPYGSGGSKAGWQTRTDGNIKRGSTLRGSRPDESSSDESEGGNFVSVSNNQNSTWAVDHNRGAGSKVSRTTSMPLATGLIPSKPAKPTRSASQSTITAKPRPKSSLSRSGTVKSAMSDATVKSSGGTKRKTRPNGSIARSTVSSNGHHSQGAGTAGRNIMSLVDSSGPVMPEVPKAPRSGSNPNMHLPSAPGTSIVTADARVPTPKKATPSAATSAGPPTLGRSVSQKSTASKKKKVEREGESEKDDKTWRPTTPLPPSRLLSPPLKSALRPTSPSPSPLPLALQEPVKPMYSISAPAPIPYEEVKQEQEREQLEIEEKEREKRAQLLKRNSYVSVQSDGASVYESAYEDEDQGTRGYGPEDTDSSDDEDGDYQVFKNEKHIRRGEMASGDPDYGKQYDDVGSDLTVGARSEHTTVAPTAPSLAPALEPPTDTPRRRKSVRMAVPDSPVTDIIPSISPPPTAPGPVFGSPSPNSNQNPHPLSLSESQPAQAPRSRTPSPEPERLEQQWSTRIGRMREDTSDEEDDVPDYVKARKKLQRNSGKWEVDGKEEKKGKGLKKKGSVKSKGIKKLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1S0</accession>
    <name>A0A1E3J1S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031078.1">
        <property type="nucleotide sequence ID" value="XM_019177046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1S0"/>
    <dbReference type="GeneID" id="30194157"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="896" mass="100120" checksum="A4792F0494571FAF" modified="2017-01-18" version="1">MASSDIEWALLRGGSIPVDTVASTLKTKELATSLAEADFKSILLSPEARAVFASTPDLFEGLPFSPASADSSAETSSAIRLIVAIALIHSFVQVNWTGPELSFNTLEVLDTTSSSEEDLNNAALPFLTLQGEPAYHLSQQPALFLLGRRLLLSLESDAQISSVPAWTLRLHLIHLALLDEPVPPPTSVLDSIKALLEDPAVKADQDLTAQIHLEQGLLHFRLGTDKHANQEFLSAAKSSGLEFELTGALGKKTKYQVAAHSQLVLLAESRARDGEGKERISADSEEGGEKLPEALLLNDDTLLEETEFTKVTRDDKSTSRLAHLDPSDQPPLHPLDQALLISFCLSQSNDSPSLGLTSQQMMPFLSRVISHPRNWSVHTTALLLRSRLEAGRSRTVERSCLQLQALIEQMPTSDSEPKERLRYFHQLPLPSKWEMESELAKRFMTVGVIRSALEIFTRLEMWEDAIGCLQKMEREEEAEGIVRDLLAGKKVESELVPTLGRATVSEMRKQKLTAAREGKLWCLLGDLALNVHGAAHDPAAARATSIEHYNKAWEVSEHTSSRSQRSLGSLYMGTQEFEKAISCFQASLNINPLYSRAWFTVGVAYVRMEKWHDARDAFRKQVGVDEDDAEGWNNLAAVYLRLEEEGVAENEAPPVSYENKMLAFRALRQGLRFAYTNWRMWQNYMIVAVDVGELSEAARAMTRVVETLANSNPEQAIDADVLDKLVDSVTRDDFSLSKDEATKVVPKTSNEGFGLLPIVERLFDVVIFPRVSDNPRVWRTHARLLRWKEDWEGAMEDTLRAWRCGPVADEGVERDLAKWQEAVTELEDLVAVLSVLGPKAKAVQESSEGEKKRKSDWKFQARGLVRTFMGRTKDSFEGEKDWERLQELLDELKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J356</accession>
    <name>A0A1E3J356_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031268.1">
        <property type="nucleotide sequence ID" value="XM_019176793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J356"/>
    <dbReference type="GeneID" id="30193892"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13385" checksum="C8A00CAE3DAD1C47" modified="2017-01-18" version="1">MSEALERRRQKQVAEDNQDEGIVASFNDEDLPPLAPSTNPLFPNAVVKKATAAHPKAGTSSGKKESGDGPQGTRKSARRSTLGQADESFDLNEFRESQDNEQRERGHSVAVTSEGGDEKMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3J5</accession>
    <name>A0A1E3J3J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031215.1">
        <property type="nucleotide sequence ID" value="XM_019176740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3J5"/>
    <dbReference type="GeneID" id="30193836"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="846" mass="95357" checksum="062701ECDC8E30BA" modified="2017-01-18" version="1">MSTPYPSLFRSEEMSLVQLYIPSEVSHDTISELAEMGNFQFKDLNPTLTSFQRPFNTRIRRLNESSRRLRLFRSQITALSPPLGIPPLNAVPPFTTVGPRAQNAYDELEEKLKEHEKRLAEMNKSYEELGKRKNELEEKRCVLRETAGFFDEAGHRHTEIRTSIDENDGTAPLLEHAAEYGSLPGDSSLTGFDLEFVSGTVERSRMPMFERILWRVLRGNLYMNYSEIEEPFVDAVTGQETHKDVFIIFAHGAELLNKIRTVAESMKSNLFQIDSAQDKRADALREVSARLEDVDNVLYNMGQTRRVELGKIAEALEAWTDAVRREEEIYKTLNLLSYDQGRKTLVAEGWCPTRDITNIQLGLRRAMDTAGTSVPAILSELRTHQTPPTFHRTNKFTEGFQTLIDSYGIATYQEVNPGLYAVVTFPFLFAVMFGDIGHGTLMALTAAAMIFWERQIAKNGVNENLETFFFGRYLIILMGIFSIFTGFMYNDIFSKTLHIWQAGWEWPSNSTGLVEAVSTGTVYPFGMDPTWHGADNALIFNNSYKMKMSIILGVIHMTFAICLQVPNHLHFKKYLNIYAEFIPQMLFFHSIFGYLVVCIIYKWSVDWSQSSVGPPGLLNMLIYMFLSPGAIDPAVQLYAGQGFIQTVLLLTALVCVPWMLALKPYMLWKDNQRIAAQGYQGLQENGNGDGRPSISTEADEEEEVGMAVAESSDDEHGEFDMGDIVVHQVIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWSMTLDLAFESTGGAIWRGTFLFIMFATWFGGTVGILCVMEGLSAFLHALRLHWVEANGKHYMAGGYPFTPLSFSALGAEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3U8</accession>
    <name>A0A1E3J3U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031315.1">
        <property type="nucleotide sequence ID" value="XM_019176840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3U8"/>
    <dbReference type="GeneID" id="30193944"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24266" checksum="A4E24DD1DE3E40B8" modified="2017-01-18" version="1">MATQLALDLRLCTLEAQLFGTPPSSLAPPDRAPQDGAATRRVREIHERLQRLGESSEGVKRLLDGYEQYLPLLTIPHPSTPTMTDQASDESQPIQESDLLPDSVKLTMVLAAAEDIVGAERDLRELEVLKGKGAEGSGQLEDLIPQRPDLIRAMQESEKEGEALAQARSQVGGLLVRYTDFTSTVSELFIDLHHKMENLEEGVARVERKRRKELAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q0</accession>
    <name>A0A1E3J4Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031525.1">
        <property type="nucleotide sequence ID" value="XM_019176597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q0"/>
    <dbReference type="GeneID" id="30193692"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18746" checksum="17FDE96933C1DE8D" modified="2017-01-18" version="1">MPSESLIRWSHRGLFALIAIASLISLVISAVLVGYYNKHGYPSHHTHAYRDRIRILLVASVWTMAWALILIIGFAAMGTSAVFGLITHLVPIAISFLLFLIGVSALTGLTDKISCSKSSETFSRCKYVKGLVVISWIDTIFIFAALIFLITLAVIARGRYGARRSTLYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6G9</accession>
    <name>A0A1E3J6G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031706.1">
        <property type="nucleotide sequence ID" value="XM_019176296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6G9"/>
    <dbReference type="GeneID" id="30193387"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130156" description="Bromodomain associated domain-containing protein" evidence="6">
        <location>
            <begin position="29"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Bromodomain associated" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="520" mass="55372" checksum="20B0D1B1CE683FBC" modified="2017-01-18" version="1">MHPAPDAVLHLAALHALAAAGFASTSRAASTTLSALMARYLRTVAAACVERANLAGRGKASALDVAEALEDLGIHVGELSEWAQGQRQVVLESDGLSGLEDHLRDGLLIDEGMGEMRLVAAEEMPDESDQDEAMESDDGVKSEPGERELFLRSRSPDLSWLPPLPDGDAPVPSTQDITAPPPPVQLESAPKSIADRYRRPIPYASSQLSQAYPFVPPPPPADPPTLPQPTTSLPSLVTTYGAIAADPSISLRQNDLRRQAAEILRRSIAPVDEFTPKDTLSTHLAPIRASPIVPSHSDLLPPKLIPVNPSSDGLLSSLVQNMSSPYLPPALRDRLTSLRPPVAQMRNDEAVLYGSAVRGPDDMVLAKTLGKQEQHPEAYLRRTWNPGPRGADKFGRRALPMGKKVVWGQEGESVPRRQATGMEEERKRDQNGVAAPAPEAGPSDTAEEDGVVSQNAAGPGPLKIKIDSSPVATSPVAMSGIDNGDQSFQAHDVARLDGDMTNGSGPHLDTTGQGQDVEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6K7</accession>
    <name>A0A1E3J6K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Eclair-PA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031749.1">
        <property type="nucleotide sequence ID" value="XM_019176339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6K7"/>
    <dbReference type="GeneID" id="30193430"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130161" evidence="9">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="24508" checksum="91B7CA0721EA047C" modified="2017-01-18" version="1">MKLAQVFLALPLLSAVNALHFYFESDEKRCFLEELPSETIVEGHYKAFLWDEQQNQWKPEEAMGIHVTVDELSSGHNVVNTRGPPDGRFTFTSHEPGDHNICLHSNITGGWLSNQHIKMYLDLNVGSAKIDQSDDKSHVTTLSSKIRELNVKVADIQREQRYLREVEADFRDASESTNTRAVWWSLLQIVVLIAAAGWQMRHLKVYFEDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6U5</accession>
    <name>A0A1E3J6U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031820.1">
        <property type="nucleotide sequence ID" value="XM_019176410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6U5"/>
    <dbReference type="GeneID" id="30193503"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN96574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="300" mass="32740" checksum="FBE07C6FFC76ED7C" modified="2017-01-18" version="1">MVAAKKVPLKAIKTLTFYADRYTLGRRTDPIPQLTCNGPGCRVYQPDVVQCTNMGDDGLGGVQWKCDTDIPSYLRLGKVDVSCEGWSRAGDSNVLQGSCGLTYDLFKVNKGLEYGDDPYDHMPSKFDRHISSLFNIAFYLIAFVILYSIARSLIAKYFPRHTPPPLSRYNPWGGGGGGGGGGGGGGPGFNSGQPPPPYVKQEYTEDSTQVPRATTWTPGFWTGIATGGLGAYMANRNQDTWGRYNRGFGDGRGPVENTRTRRFWDDDYDWDRGVGPSRRAGGTPPGEMRRATGFGGSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7D9</accession>
    <name>A0A1E3J7D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031831.1">
        <property type="nucleotide sequence ID" value="XM_019176421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7D9"/>
    <dbReference type="GeneID" id="30193514"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1161" mass="125553" checksum="03F01A14224D377C" modified="2017-01-18" version="1">MKRIFKKAPLVDPLPPPSSQPPSNPPSGRSTPGHQGGRSIAAFFGGGAARESSDYDSAQQHPSPQQQLQHTPHHDHNKWGFGMHHQTEVTPFPSDARAEQTPPPIGQKGKEGSSGAPSMLEIKQMQERRDQERSQTEDPASRDSRRRGQPQQPPPIHPGQRTSRGYQSSPSPDGWTNVPTASGAAGGAPGAAYEGTYPQHALPIPNASFSHQSQAQSYAHSHSSVNSSPSSQSTHTPMFLPPGARPPTPPTSRPPYPIHMRYSQSSLKQSTTPNAMCGECNEGKSGRERGYSSPVMTTRVDGHQNESVATQHAMPRDGSAAKLQKQQPANSRSPLAHTYSTLSSTDNPPTFPSPRPYTPASGAATPTPQTQPNHISREQPQRATPIDLPNPHIPVDDQMHGDKDLPLPPREEQQPPDHEKAKEGKKKFWGITVKSSDKKNKKAQAESHASGHGLMQSVSLQPNAVGDWRQSVDEARRSSDGRGLDMIDSLSTSTHGQNVSQNEEEPKGRLLGLDFSRRDNAAAAQVNDVASAIQILCTSPDPSPPAIYEVCDRINHSGQGESIAKEAARALRKELKYGDEMQRRSAGKVWFVLMRNITVKGFKSDPAHATNKKFVQALEPILTTPVAKATVSLSTKKLLTDILADLTYAYGMDKECGGLIDLWKKVKLPQEPDFGRPMPQDHPIYSHNPDQPPTSQMANLQVHPAPASHSSHNSHISQSTSLPPPPRPPRNYAGPGFAAGPGYKDLPSHSEDIRRLEEECTAAQESAKLLGEALLYTRPEELEYKPVIREFYPKVFHAHTSLTNQMDWAQAEASQSRERLSKSGALVIHDGPPADTQGPESTLEERALATLFETHAMLAEVIKQHDDLERMAVDEKELREVRERSKKETRMDRGQQMQMLSVGPTSGAASSSRSPSPTPAPLLPSVQPAPQGGNLKSNNPFRSAAPAGSRSPSPDRHHLPYAPRDTNSPSTGRTVSPLGGAKLRMGPRPLPNPSKPSSAVPTPSQTPAPGATASSYGGSQSAPSRSGTGDSNGKSSVGKDGEEIDGDDLPKIPLKPSRKALGKRRAVVDEDNNFDPNDMFNPTSTDPRSTVPSSNNGLPDGEGSDESLLLGDDFTKVKPIVYAYDAYEERQKELKRLKELEERARASSGFSGGSGGSRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8R0</accession>
    <name>A0A1E3J8R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase 1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031862.1">
        <property type="nucleotide sequence ID" value="XM_019175949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8R0"/>
    <dbReference type="GeneID" id="30193036"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000030">
        <property type="entry name" value="Histone deacetylase 3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="484" mass="53796" checksum="C0EEB7023065B17D" modified="2017-01-18" version="1">MSGSSSSSERPATAPRRVSYIWSAELESVSNNLPSNVGRSSMVHDLIRSLGLLDSKLGYEMEENHGGESREREDIDNSGRIRPMARITPPDPSLGTKACLLRYHDRGYIDRLYQPENDSNEPPEDPTHLPSSPRSSSSESSPRPRKILRADPYNLSHDNPIFDTLPLYASLVSAATSTACRLLAQDKADWAVCWDGGRHHAKRKEAGGFCYVNDLVLGGLLLSREGRVTVYPQQVGKDQTPKVKTRPPRILYLDMDLHYGDGVSAAFHSPKAYPYPLKPNQPIPKPPNVLTLSIHHSSPVFYPPPTPLSLLPSPDTTSPFSLSVPLAAYPSRETYAKVWTMCIEPIQEAWNPDYVILQMGTDGLPGDRVGQYGNWAVEGEGGIKWVVEQAKKWDAKVCVTGGGGYRHENAARAWAEVMGVLLDRDFEHDMAIPHHNHFEQYAPSFTMQVPESHVRDENTEEELSKAGTVFKVLADRINFIVKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8S8</accession>
    <name>A0A1E3J8S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031732.1">
        <property type="nucleotide sequence ID" value="XM_019176322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8S8"/>
    <dbReference type="GeneID" id="30193413"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="152"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN96486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="457" mass="51647" checksum="D1795714AA2D6E17" modified="2017-01-18" version="1">MIDLIHFQTDKGGNPDVVRESQKKRGAPVEIVDEVIALFAEHKAAQFSLEGVKRDLNVLQKEIGQIKKNKGDASAQLAKKAEIDKEILDITARVQDLIKQRDQKAGQIGNIVDPQNHVSMTEDDNPVLKLWHPEPNHKGNSEMLTEADKSTDILSHHEVLARLEAYDTDRGVKVNGHRGFFLTNDGVDLNQALINYGLDFLRKKQYKKVQPPFMIKKEIMGATAQLEDFDEALYKVQGGDKDMYLIATSEQPISAMHMDENLDPKNLPFRYAGYSTCFRKEAGSHGKDTWGIFRVHQFEKVEQFIVCVPEESPAHLDNMVANSRDFYESLGIPYRVVNIVSGGLNNAAAIKYDLEAWFPYQGEYKELVSCSNCTDYQSRSLNVRLGFKEKDKKTGFVHMLNGTLCATERALCCLVENYQTPDGLRIPKVLQPYMQGRDFIPYTAELPKTSTSNKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J900</accession>
    <name>A0A1E3J900_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translocation protein SEC72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031647.1">
        <property type="nucleotide sequence ID" value="XM_019176237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J900"/>
    <dbReference type="GeneID" id="30193328"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="256" mass="28338" checksum="424DBAC4FB94E244" modified="2017-01-18" version="1">MAQQQPRPGPPPGMQPQQQQQSPLSPAHLEVLDSIPHTDVPHTLKMNAIPPNGPPDLAGKTFPVMLCKVHDHMKCDSCGVDFTGVNFIHQFLRFAPVEAIPPPPNVKPQPQRAQMVMALKDQGNAAFKVKKYDVAAQFYSKATDSALSRPPWEPAALGREEAIIMLGNRSASHAYMGNWPAALADAETCIALKRSWMKGHVRKARALMGMERYEEAKQAVVDGLQYEPREEDLNTFMKEIEEKIGETNASLSHTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J927</accession>
    <name>A0A1E3J927_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031982.1">
        <property type="nucleotide sequence ID" value="XM_019176069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J927"/>
    <dbReference type="GeneID" id="30193157"/>
    <dbReference type="OrthoDB" id="2592707at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="527" mass="59116" checksum="A27B148752940AEE" modified="2017-01-18" version="1">MSRFARTPPKLANEYLKEESAVTPGPSRVRINQLHGQVSELVRKNQTLDASLSYLKRSTTANIYFQRKLISEATHYKLAIQTKDDEIKAIKDASRIVRKELEWFKKELEHCVSEGSSMRDQIQLHSGIQQQKALIALAQEQMRVVEIENQLLESDRARVLRDHKISLFQAREEELLADLEERDAKIDDLESDLAMMSSSLEAERNTAQSATSARPSSKELRQAQTEVLSARAEIASLQTKVESLESKTRALKSSEKEAKSELENWLREEGSVSSKQKEKTELRTQMRGLEFELGKRLEQVEELKEDLKKAKKDGKERERLPKDKLKDAQEKAERLQEEQEESRASAHKSGTGKRDKARKASPEDTESEDESPKKKAKKAVSVSKAPFPNAKPQSKAKRAAESSLASDSEADRPATKKVKALSKTQATPLEESDTDNKIKSSKVKVAGKNEGLEEDGTDISKDGDEKKKKKKRTLGIQPKPSFSWDHIMDSGDGVIPSYLSPAKGGGKPTGTIPRMGLSIPNRMKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J997</accession>
    <name>A0A1E3J997_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032050.1">
        <property type="nucleotide sequence ID" value="XM_019176137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J997"/>
    <dbReference type="GeneID" id="30193225"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="444"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="773" mass="84135" checksum="D69F904E16FB22F9" modified="2017-01-18" version="1">MPGPAPSAHQVLVYSGPGVSPLSLSHTLLTLRLILLPHYTVQPVTPEILYSQPWEPSCALLVIPGGRDLPFVEALTERRAVTEKIREYVQEGGRYLGLCAGAYFACEQVKFDVGGGLEVCGKRDLGFFPGPCVGPVFEGFEYASEAGSRALTLNLETGSREVHHIYYNGGGHFALPSPAPANVEVLARFNYPASSPASEQRIAVVLTKNGKGRTLLASVHPEYPLSDPPASNAIEKLDVHLTKEELEVSDKARVAWVAELLVSLGLKPPAHESISGAQTDIEEDPALLFHPTHPSPIFLLSHPSLPQLPSTAVNKTELKSKMVQVDGWSFLRDANDEVRFGEVEATCEDAEASEESVAKWLGTARRTKPVFEPALDKLSLDEESDVFRPPPPPDLHSLLKTILLASPSIPYSPRWTPLFNLSTYWNELDQARKRLGRRSGIMRPGRDGLDERCSLGDCVLYGETVTSTQTMLDANPLLLSNLPAPLAFLASFQLSGRGRGGNMWLSPPGCLQFSILLDLPQELSSKMVFIQYMMALAVAEAVDEDGRLGVRIKWPNDIYAEVEGVGGSEVGSGKKGKAKLGGILVNTSYVGGRWRVAVGCGINVLNALPTTSLSQLHSLQAAKLSSSNKPLPPAPTMEGTFARIMSFFDAKWEQFIEEKGFKGFMDEYHGRWLHAGQEVTLTTTEPHTRVRILQITPDHGLLRCIPLSNPRPQASHGLTPLYDRNVDEGENDRGGWSSKQSSGAGSNGSSPYVDLQPDGNSFDLMSGLIRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBV0</accession>
    <name>A0A1E3JBV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032222.1">
        <property type="nucleotide sequence ID" value="XM_019175732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBV0"/>
    <dbReference type="GeneID" id="30192817"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="23549" checksum="91F0E77BD85DDDFF" modified="2017-01-18" version="1">MVTYIDIPSAPKRLAYILSTPGKRVATEIDPAYPTVLLCHPPTACGYYYYYGQLEDPSLNEHYNLLTIDIPGHGASRMKEPLEGEITWGRIGMLFHEALQAFGVKKVHLVGSDMGGQAALSMAIAHPEMVASLIMLRPNGRPEPEIVAMGFVEWFALQAELIESRDLDLIDILVSILLEFVTGQMTNWILRDICEGLGDLCKAKFMRGEVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC86</accession>
    <name>A0A1E3JC86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032331.1">
        <property type="nucleotide sequence ID" value="XM_019175841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC86"/>
    <dbReference type="GeneID" id="30192927"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19206" checksum="ECB7250B1DF52C3C" modified="2017-01-18" version="1">MSAQPEKVNVLMVCLGRSPMAEAVLKHQITARPDSFKARFDVRVDSAGTGAYHEGDSADSRQKLIGSQHNVPINCIARAVERQDFQKFDYILAMDQNNLETLLHRKPAGSKAQVSMFGSFDPSVPKANHGSHKTRAKEIDDPYYGGRDGFDKSFERCTKFGYGFLDYLETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCH3</accession>
    <name>A0A1E3JCH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032247.1">
        <property type="nucleotide sequence ID" value="XM_019175757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCH3"/>
    <dbReference type="GeneID" id="30192842"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="349"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="738" mass="79587" checksum="8BCBF5B4F44CE0CE" modified="2017-01-18" version="1">MSYSTTSRDSNKPTRLYQPSEPEAGTSRAAHPYYVPRSQAPINPSTIPPSPSFSLSPEMSSTAAHSSYSSSFYSSRQSFAESSQPQYGFSSSAILPPDLARVAPPPSTLVSKGSYVTIHRWGPSRGTPGSFVSVTCDVDVQNPPLNAGHPATPPPSAGGRGTRTLRLLFGNHPVQTSAQVMQPEGYRASCMLEATVPSLAAMGRSPEGTGAQAVPVTIQVLSDDAQVLETVPLGQFTYASDSNLARKRSGEPLESTRRSPTESPFQRRPSGYISSPEMKQYDPLTSWSGASKSHNRRTSTSTMGSSSHSNRPSSSSSSMSQPSFMRATQVIGGAPLNAANTPYVSTGQKAILNLTGDLTGVAKGWNSEEWSARRRLVQFWRRQEGTTIHAQFQVVAQAEWASIQSSIVVSCMFWEEKNACFISSVDIIYLLEALVGTHFTVEEKNRIRRNLEGFKPITVDKSKPDTAKFFKQIMNLPNPRPRNIEKNVKVYAWDCLEVALQKIISKYSASFPANQVEGMTSSGAPYRVPQPSDPASPLMKVYDPLSTSSQYSVPPSSHPGAESLYSGQASYSQLPSSRPQSSSSSTTQLLSNGDLSRPSTAGDPMGAPGQSPGPSSSRPGNSGVGLYFDMPQGYSQKQNGQYHMGSLSGNMDVPPSTPMSSAQMGGMYAMPPPHSQPPYTAAPQHQYPAPTLSQTQHMEGYPRQGDMGMFYPSFGSDGQEIPPPSSYGYLNRDGRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JET1</accession>
    <name>A0A1E3JET1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032456.1">
        <property type="nucleotide sequence ID" value="XM_019175353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JET1"/>
    <dbReference type="GeneID" id="30192434"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="84"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="758"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="916" mass="98572" checksum="0ECCB100735A1ABD" modified="2017-01-18" version="1">MVVLTTRNRKRAWFLLTATVSIHIILLTATRRLSDRRFPKGGGLIKRFIDDHDASGPLDFPYIEWYNALPPAWRPFFIILLLCILTFLFSFIGISASDFFCPNLATAAAYLGLNESTAGVTFLAFGNGSPDVFSTFSAMSNGTVGLAVGELIGAASFIVSIVVGSIAFIGPFKVPRHAFRRDVAFFTIAVLVLIITLHDGQLTLFESGGMVGLYLLYVAVVVSENWWKKRKRRWIFLGKRRVTQSRESSGDTAKILASLSPHPEPERPAPVPITDHDSTSLSPAVSSRRRSHSSSHLLTARHLDPLDTPTPRANMSLLGAIEFRDVVNSLRKEGGSIYSGRSSRSASPTGTVTPRMTGRERGDYFGNLGHRRSSSHTFGRGGPGTPGGSSKRIQSNSVRRGSSQMTDQSPERDRRMTLPTRHSHQGGSPAPVGLGISNAPESNPWHDQPGNPPTPSPQLQLPPTSPAKPSLTKLVIPGDNIAAREVPSISVLDPSGQTASPIPASPPLTSKRKRASKHVRAALKILFPSMQSFRHKSILGMVLAIITALQILALTLTLPVVDDGHEMEEGEIQLGEGEGLPLHDSSGSDGEGEGESDGEEGGDEDDEADRLLNPHVGEELHHLVDHGFSPLHSPLGRIHHSAMRKMGYHPESGGLSPVRSEEYAEGEGEEHLDETYDDVEGSDGRREECEGALEFKKYLTAVQCVLGPLFCCFITFNGLSSFKWIALGTTLAGLIASVPVIRYASDGTAQPWRLVRCFCGFTCSMVWIAAIADMVVDVLDTVGEILGLSDAIIGLTIFAVGNSLADLVANVTVAQFAPTMAYGACFGGPMLNLLLGIGGSGSYHIITSTSHKPVSVDFSPTLWVSATGLVVILLATAVWVPVNGYVVDKRWAGCLIVAYVVLMSVNVGVELKTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFE4</accession>
    <name>A0A1E3JFE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032631.1">
        <property type="nucleotide sequence ID" value="XM_019175528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFE4"/>
    <dbReference type="GeneID" id="30192611"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39547" checksum="7B61B33ECA3A1887" modified="2017-01-18" version="1">MSQPPYGMSSRSPPPLQHPKPTHIAYPPPEPPRTPAQSTDSSPYSHPQRISQDGYVRYSSPAVADPMEGSTSGFNAYAPPSHGKQPQMQARQAYAPEGQGGYGAPNYGQWPGMNDATTQMGVQFGKSAVAAGQEYMEKNFTRFLPLQLIKVSFSVTNLYVLNKLRLVLFPWRHKPWSRQTRRTVDGAVEGWAAPRDDINAPDLYIPTMALVTYTLLAALASGLQSRFHPEVLGVSFSKALAVVITEFCAIKLGCYLLDVRNSGASGVELIGYGGYKFVGIIITVLSSLLGMGRMVTIGVFVYVFGANAFFLLRSLKYVLLPDASVSSSVATLSHAQRSRRIQFLFFVAVAQVLWMGWLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFE6</accession>
    <name>A0A1E3JFE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U4/U6 small nuclear ribonucleoprotein PRP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032646.1">
        <property type="nucleotide sequence ID" value="XM_019175543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFE6"/>
    <dbReference type="GeneID" id="30192626"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="192"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="436"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="64220" checksum="0EC6345A418C05C1" modified="2017-01-18" version="1">MSARRPADNSAPGQPGPKRPKTNAPIDIAAVRAQLAARKAALEQQKLGGASPAPASGSASPAPPTPGPAVLPKAPAIDGGIQAKLAAARARLEALNPAPAPKPNNPYLSGSGNVPKTDSPQPAVSSVALHPLLMGDNNPQQAEKEKNEKKAMRDRYKPMAPKFSSVRANASAAQAPSRASPAAPPSAATSFNPYASNSASASPAPDEGRGATRKSRKLQFSRQGKYVEQGDQLRNEQKMEALRLRIAEASRKAGLDSEFDTLERSFKRQPPPAIEWWDEAILPKGTSYEDDLEPAFADMVTNTASLITHLVLLPIPIPAPQDRKQAERVLMLTKKEQKKMRRQRRQAELEDKRDRQKMGLLPPDPPKVRLANLMKVLTSDAVQDPTKVEAKVRKEVAMRAYKHEKDNNDRKLTVDERKEKEYNQMLAKERNGIRGAVFKIKYLTNGRHKFKVRETAKSDLLSGICIFHPKFALVFVEGVDKSVKHYKRLLLNRIDWTEQARPMDGSDGSDGEGGKGGADGDQDLADNKCELIWEGELTERTFKMFRARHVETDGKAKEWLTPRFEGMWDLAKRWKWEGEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFF0</accession>
    <name>A0A1E3JFF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_03247</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032482.1">
        <property type="nucleotide sequence ID" value="XM_019175379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFF0"/>
    <dbReference type="GeneID" id="30192460"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="99"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="280"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN99405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="441" mass="49794" checksum="0DED7CB93ADBB5A1" modified="2017-01-18" version="1">MRWKQVATIGAGKISRGTRKEQERKDGHDLMVANVLWHASRRVNKGAADQGLQMDGDLIQSNWDQVVDHFDNMELKPELLRGIYAYGFERPSAIQQRAIMPIITGRDCIAQAQSGTGKTATFSVSILQRINTDVKKTQALVLAPTRELAQQIQKVVIALGDYLNVDCHACVGGTAVREDMAKLNEGPHVVVGTPGRVFDMINRGALKTDSVMMFCLDEADEMLSTGFKDSIYEIFQLLPAETQVVLLSATMAPDVLEVTKKFMRDPIRILVKKDELTLEGIRQFYINVEKEDWKLETLCDLYETVTITQAVIFCSTRRKVDWLTAQLHERQFTVSAMHGDMKQEEREVIMKEFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSSKENYIHRIGRGGRFGRKGVAINFVTNEDKQMLTEIESYYNTQVEEMPLNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFU8</accession>
    <name>A0A1E3JFU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032612.1">
        <property type="nucleotide sequence ID" value="XM_019175509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFU8"/>
    <dbReference type="GeneID" id="30192592"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="5">
        <location>
            <begin position="151"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="36106" checksum="D60CC9D07015B72D" modified="2017-01-18" version="1">MATNEQGVVSTTASADLHTHFHAQKQDILQACETPGASLSHIARLIQDLRKLVDSYGEGLPKYDRGRYTEELNGLDTKLSTLRTKDKPKSRFAFAKSKRPLPAKATPQSPTVVAGPSTDREETSPNVERSPINTHTIEGRSSALVRPELAPGTGTYTLSLSSVSHCLIDLRPCKSPSSTDPSQSALPVLTTLHAKKLTRCVLLAPVLPGSAMLSDLDNCLVVVGAQQFRMHSSTKTKVLLNVASLPVIEHSQNLTFGPYPDLLLPQTPDYVSKHTEVQDFDWVRGGQSPNWSLLAKDDVPEDLLVQLSEQLDGGMDDRPSVDIWIDCLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JGX4</accession>
    <name>A0A1E3JGX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dityrosine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032443.1">
        <property type="nucleotide sequence ID" value="XM_019175340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JGX4"/>
    <dbReference type="GeneID" id="30192421"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="121"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="664" mass="70779" checksum="A65EA28C76B0EF48" modified="2017-01-18" version="1">MPTESHHHSDADIVVSTTASSSTTLISHASPTPETGEEHKLKSSNSSLQSNLGGPSRRVSQGDVQDASLDDGILDAPPDRSSRCSKSGEGEGSGNATEVEMIDGRPKDVYDRFTKRQKYMIVAIISYSAFIGPMTSSIFLPSIPVMSTDLHSSTEVINYTVAIFLVSIGVAPIFWSPFAGFYGRKPVYLASMPIMVVASVGVANSKNIGALIGTRILQGIGSSSVLSVGAGTIGDIFRPTERSSGMAMFYMGVLIGPTLSPIIGGLFTEYTAITWRAAQYFLVGCSALSVALTLFFLPETAHPPTMHEKLKKETGKKFVPYFVNPVGSLLLLRWPNVAMACVISSCILLDTYCVIVPLSAVFKERYHINNSAIAGCLYLANGVGNMISSKLAGPFADGIVKKYIAKRGYRRPEDRLRASFWGLALGMPVSILVYGWVLNSGKGGMAPPLIMVFLNGLSLMLAVTPINTYLVDAMQSRSAEVVAVNNCIRYIFSAAASAFVIPLANAIGWGWTMTICSFVGWGATVALFFLIRYGEGWREAANIRYGVTQREADEEKADDGRDEEAAVRGRDESTVERVDEKDKRSSSVEGDGEHGEHPVDLERTFTRPAGGARGGKGSGSGYGSGAEGAGLQRQGSRKVGEAPGMGDVLKRQVSLAGGSIHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI53</accession>
    <name>A0A1E3JI53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032720.1">
        <property type="nucleotide sequence ID" value="XM_019174988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI53"/>
    <dbReference type="GeneID" id="30192060"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="279" mass="30720" checksum="4272C313C68AA5D2" modified="2017-01-18" version="1">MSPWNAPRAKLRCVPQVQLKLSIQRLRTLQQKKHALAKASRRSIADLLAQGRVETCRLRVEGLIQDDIGVEVLEVLELYCEKLQARFNMLDASTQYSGTEPDASISDAVCAIVYAAPRTELKELQVLRDILMHKFGRPFALSLLPTEPPPDTVPARLTSKLALYQPTPELVDLYLWEIAKGYKVEWVPESVASETAAAAAGEEDEDEDEGGEEDEDEDEGGEAEGEDGEDGDKGEGKEGGKEGGEQKESTKGKEAEGVKEKKLSPEEELAARFAQLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY0</accession>
    <name>A0A1E3JIY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032977.1">
        <property type="nucleotide sequence ID" value="XM_019175245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY0"/>
    <dbReference type="GeneID" id="30192325"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="165"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="37348" checksum="F783CB741A61CD09" modified="2017-01-18" version="1">MGPTTDDSQDVPDPESPAFQAFLDDHFALGGKLTESMAQWNKHSLKHNSTVQVLNLPSSSSHNEIRQELGVKDYWCGRESLHTAESLRRSSHQQPHSSTAPKKRDSGTFSPGGMVRSLSGKLTRQHKDLPSGKASVSNGSAVEDGELLEEVRAAKVMNTSPEGLYERFRRGLLEYHSENEREYIESCRETECLHVYKKHVAEVWRLTYKTPPPTNPRTFVVLLLSRELVTSPKGERTFMNISIPFVHPDCPEKKGGEKGRVRGKYVSVERVRETDGGRTVEWRMATSSDAGGNIPRFVTNGSLPNSISEDVPSFLSWMVERFPEGGEVASQPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ28</accession>
    <name>A0A1E3JJ28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032828.1">
        <property type="nucleotide sequence ID" value="XM_019175096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ28"/>
    <dbReference type="GeneID" id="30192170"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="913"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO00636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="948" mass="103400" checksum="82490F828A265643" modified="2017-01-18" version="1">MFERTLQDLIRGLRAHKSAPKAQEDAFITEAMAEIRDELKGKDMALKAEGVIKMCYLLMLYPIPPPAGFAFHVVEVMSSPRYHLKQIGYLAAPMVFSGDTEEVVLTVNGIKKDLLSPHASLPPLPLTALPHLLSLSPSLSTSLNPDLLHLLTHSSPRIRKRAVLCLLPCWEAYPEGLREGFPRLREKLQDSDQGVVGATVGVVMELARRQGGKNYLPLAPELFGILTGSSNNWMLIKVVKLFAILTPLEPRLVRKLLPPITSLISNTSAISLLYECVRTCIVGGMLDPDRAEADALARVCVEKLGGYLRDEGGDQNRKYIALLAMVKIIPTHPQMVAEYQEEILQSLDDPDVSIRMRALELVTNMVDSDNLQTVADALLSHLAPQAPALPSAAASLAAIASSSAPTPTPTPSLSPAYRLLLTTRLLHILSYDTYAYVTDFEWVISVLIDVSYVSRVDVGSEVKKLILDIVGRVKSARGYAVSVLEKVLADDEFRERIGDDGESAAGLVDAAIFVCGEYPDALVSPLSTISNLLSPFSSPELTAPAIQSVAKIFGFYCMSSASAWSQDKFEETKALVGSIEKGLQEVVAQGKGDMEVLERAGEAKGLLGFVRADLKHHVPPKETVRRDMDIPEIEGGFETEGKAEKEANEPVYPKSLYIFPPLSTAYPLNAVASHAQESISVPEGLYLDVDIVPGGGWPDDLQDGEESDEEREREKQVGALDLGEGGGEGMEELRRVLREGKKKKKGKKGEGEEDKAEKERRKAARRAKHKDDPYYLYDKEDAEVDNIPIVKLDDPELPAEPSHFTSKGKAKTKLKKKVAPEIDRTGELPEGSALTPPTRPSASTSRANSSSGLAAVDLSASSSNNPLSRGSSGFEEYRLDEEEEEKERTRSLVNGNGMGHDVIEEKVVEPAISTPAVQVVKVKRKKKDKGEKKKSSKEKVGKSGDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKB9</accession>
    <name>A0A1E3JKB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein Swi5/Sae3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032759.1">
        <property type="nucleotide sequence ID" value="XM_019175027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKB9"/>
    <dbReference type="GeneID" id="30192099"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="132" mass="14517" checksum="0437931F84BF05EF" modified="2017-01-18" version="1">MPLPLSSPSPAFNPNPHPKPLKSSPFKTPSSTRAGGISSAGGNKAGVTPKSMRGNSIFVEEKVGELRKEVEELRKVLGDKDPNKILQQHIHLLHTYNEIKDGAQSLIGRYALMTNRTIRDVHEELDLPLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL09</accession>
    <name>A0A1E3JL09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_03134</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032999.1">
        <property type="nucleotide sequence ID" value="XM_019175267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL09"/>
    <dbReference type="GeneID" id="30192347"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130424" description="Inactive metallocarboxypeptidase ECM14" evidence="19">
        <location>
            <begin position="25"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="20">
        <location>
            <begin position="194"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODO00807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="57427" checksum="578FD76DE704ACDD" modified="2017-01-18" version="1">MPKPRPYSISLLLALLPLLALAAAHEPLTPLPPTDGQRPLSVPPLPAQSSSGSGKWRLSERYDGEQVWRIRLGGGDLTRMRDILESVDDFDLDIWGTTATTIDVRLTDRQKDMLESALKLASESALESFIPDLQALIEATAPTHHDISDSGIQDPLHQDLEESSGGPEISKKKSKPPKPDPFNLTTLLTPFHDSYHSLADIAKFGDCLVETFNGEQGLEVWDFTVGTSWEGREIKGWSAKFGNELENGEDGDEEPRREIVIMSGQHGREWVGPSSALYFLHSTILSALYPSINPDPSLLLRHFTVTIIPLINPDGFEYSQHHRMWRKNRQEVGHKSCLGIDLNSNWGFKWKGQKKVRPCTEGFPGREAFEAEETKAVADWLESKKAEGVTIKSFVDLHSYGQLFMFPYAHSCDDFPVDAEMLMEAGMGVAKAIRTTHGQAYETGQACDLTYRQPGDSVDYSYGVADIRWSYSAELRDTGTYGFMLPKDLIRPTAEEISAGILHLAKFIYLMEVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM06</accession>
    <name>A0A1E3JM06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033105.1">
        <property type="nucleotide sequence ID" value="XM_019174726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM06"/>
    <dbReference type="GeneID" id="30191793"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000063">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="178"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="601"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="867" mass="96087" checksum="DD3A1A9DE0473A7B" modified="2017-01-18" version="1">MTVSSYTPIDPTAPDDQQASARASRLSFLLDKSTIYAKIIGDRMARQQIEKRKAEQRAEVRKANKEKKAEVEEPVAKGRAKGTRASAREKKVEPVEAEVEEVKGKRKRQSVGGRGEKKAKVEEEADEAEPLESPTKPTGDADNEAEAEENIQYSFKQPELVTGAKLRDYQLAGVQWMISLYENGLNGILADEMGLGKTLQTISFLAHLRAKGTWGPFLIVCPLSVLNNWIMEFEKFTPDIPVIMYHGAPDYRAELRATRLQPPTATPMGSTSAKTKGRKNTKTGGNTTASFPIVVTTYDICMKDKQFLSGIMWKFIVVDEGHRLKNLDCKLIRELKSYTSANRMILTGTPLHNNLAELWSLLNFILPDIFDDLDSFQQWFNFDEMNNNTTTDSLLDKTNVVSSLHAILKPFLLRRLKVDVEKDLPPKKEYLLYAPLTQMQKDVYQAIATGKIREYLIDKVTNGDSGANTPVEEPEPEVARGKGQRKKNKVNYEIEENDNKYIDDLESGKTRSTGITFTEKSATDVGKEWALKQASTSSQSFHGMADGGVAKRVNNMHLQNIVMQLRKISSHPYLFEWPSDPTTGQLVVDDNLVNASGKMLLLNRLLDSLFERGHRVLLFSQFTTMLDVIEDWATSYKGWEVCRIDGSTSQESRREQMDSYNAGRDDPDACKLFLLSTRAGGLGINLVSADTVIFFDQDWNPQMDLQAQDRAHRIGQTKPVLIFRLVSAHTIESKILQRAGNKRKLEELVISQGKFGAGAGGAGGGGGGKETVAEMAKALLALEGEEINVASKDDQIISDADLDILLDRSSAAFAREKGWSAGLGKTGADGGAEQLKKGEKTLFEVFESAKEGEGGLSGMFGGTEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMK0</accession>
    <name>A0A1E3JMK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033295.1">
        <property type="nucleotide sequence ID" value="XM_019174916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMK0"/>
    <dbReference type="GeneID" id="30191987"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="624" mass="69553" checksum="0F9878E48C61D89D" modified="2017-01-18" version="1">MSLPSPPAPNQADLEKAQPFQCAVCQRRFTRMENLKRHAKLHDKTTERPVFPCSECKSTFSRADLRRRHVTSKHGDESSRGKSTSPKDSSYKAVSIIPEQLPDALATALYQQERSIIDRFPFADLGGPASVQYQDTNPAPIDFRRQSLPSTSSSTTSLLQRLRLSQPPSSAIPISVEDDTLHPMSIGPAVQSFFAYAPHMFPFLHQPTFVSESCNPSLLFAIMCLGLHTAADSLTDHEKAMSCYRAGLSGLDGTLEKAGNLKPSEVLPIIQAHILLEIYAILALCGEHTSRGLNLHHQAIQIARKAGLMEPYPTQPSSTQDLDMLWRQFIKGESHKRTLYALYINDSTWYHFLSRPRSLSHLEIKHELPCRSSLWDAVSATDWAHRSLVASTDTACPRFLDTIRRAFSSNLDASLQVDSYGASLMTHFVLSSVREMTGWSTMTGRSCFERFESLHTSMVKLEPLVSVPNHAQKSPTTAAAEATWRMSMIELLLWSQSHTGGLVEDSIDGAMAAIAMLGSNPMLDINPEIIQSVEHHVNWFLLYLHRTGPDTRYETPFLSFYLFKAAVIAWQIVRSGGSGPLETVGVSDIDSLLGWIRAMFERRVRWGIGKIVSKTLAELQSQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPH3</accession>
    <name>A0A1E3JPH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033289.1">
        <property type="nucleotide sequence ID" value="XM_019174910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPH3"/>
    <dbReference type="GeneID" id="30191981"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="773"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="842" mass="93190" checksum="892A9A8C35C0ED43" modified="2017-01-18" version="1">MVSTASGVRVIVKGGVWRNTEDEILKAAISKYGKNQWARISSLLVRKTPKQCKARWYEWLDPSIKKVEWSKTEDEKLLHLAKLMPTQWRTIAPIVGRTATQCLERYQKLLDDAEAKDSEEFGMGAGEDEASKPAADARGLKAGEIDTDPETRPARPDPIDMDDDEKEMLSEARARLANTQGKKAKRKARERQLEEARRLAFLQKKRELKAAGINLRAKPKKKGMDYNADIPFEKQPAPGFYDVTEENAKVYSAPVGSSLRALEGKRKQELDEIDERKKKQKKDDGKGNQTQQFVAAREAQIKKLKEQEQVIRRRKLNLPVPQVGERELEDIVKIGQVGEMTRELVGDGNAATEGLLGEYEALGAAKTARTPRTAPQRDNIMDEARHLRQLTSAQTPLLGEDSTPFQGGRAGTGFDGATPRHSAEATPNPLVTPAHGNVLGPSRTVTGSTPMRTPRDNLSINEDASMYGETPISEKQRLAASRRALKAGFASLPKPENNFELAEDEEEEEGEEEVELLTEEDAAERDAKMRAAREEEERRELERRSSVVKLGLPRPININLQNVLRELNSVEEAIDAELTDAFQLVNLEVALLMQHDSIAHPLPGTSIPGGTPSDYDMPEDEFVAEAKKAVHAELAGTMGLPGASEEQLRLAIGSSAEEDDAAFADAWAKQREELIYSPSTRKWVEKASLSPEQLSAAYTHAISASRDRVIAEATKAAKAEKKLGKQLGGYQAINGKAKRGISDVLEEIQQTKRELETFLMLKGIEESAAPARLEKAREEVGVMERRERDLQARYAELNDRRRAALASIEQLEEDKIVLAAQAELEAQGGEVEGDVAMDGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR24</accession>
    <name>A0A1E3JR24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033380.1">
        <property type="nucleotide sequence ID" value="XM_019174328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR24"/>
    <dbReference type="GeneID" id="30191387"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="871" mass="98758" checksum="D594185C6F57B743" modified="2017-01-18" version="1">MSFKQIGKAKLTTPNNVLFIDNEVPPSNAASAVTTPTEQQADPFTSTADRADYLTKALEKSQAPGQEAGLPPNGVSRVGKMGREERKLPDINAEPSEYYGGAQVWSRARTFSNAGGAGDYKRRPLQMGGEKIGRNRRLSHDEVTPSAPRRYLIDVEETMRLVLEQEDTDNNFQISVYDSGPKLLSLGTASSNAHKTFDIRGTYMLSNLLQELALAKDFGRKRIVLDEARLAENPVDRLSRMIKNSFWNALTRRIDAQGLEIACADPKNKDQSAGARIYIPHGEDEMAEHYRQIGRDNPNLKLEVNILPVHCDDPAYVKTLNDKPGILALAMDRKVDADGKVTLDAFPFVVPGARFNEKYGWDSYFMALGLLVDGRLDLAKGIVEHCIFEIKYYNKVLNGNRTYYLCRSQPPFLTDYALQIYNQLDRSKPEENKAWLKRTIQAAIKEYHRYWMQEPSLDIVSGLSRYRPSGLGIPPETESTHFTHIVQPYAQKLGISVLEYLDGYDDGTILEPELDDYFMHDRGVRESGHDTSYRLDKKCADLGTVDLNSLLYKYEFDIASAIQVIFDDHLEMNEEFELSPWPITPEAFEEGAPRELSTNVVQTSKHWFERAAKRKETMDKLCWNDRLGMYFDYDTKARKQTRYESVTTLWPMWAGMASEEQASMLVHNALPKFEVAGGLVSGTEESRGIISLDRPNRQWDYPYGWPPHQIMAWVGLERYGYIDDASRLAYRWIYMMTLSFMDYNGIVPEKFDVVELSHLVDAEYGNQGTDFHFVPREGFGWMNAAYQVGLQCLSTGMRRAIANVVPTWEFFNLPAPDFDLAAKRRNERDIHDKAAAASGHGGQPKNDTHNQPPSLEQAIAELKLEFSGPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRF4</accession>
    <name>A0A1E3JRF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033495.1">
        <property type="nucleotide sequence ID" value="XM_019174443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRF4"/>
    <dbReference type="GeneID" id="30191504"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="30945" checksum="31176B563E205430" modified="2017-01-18" version="1">MAATTAPQFKILNKIDTIPVVHDSVTYAHGLINSHPLGASLYQTAVGVASKGYDAATPVLSRTKPLLESVDGLAVATFDRAASTFPYPFTTPTSDLPGVQKLTDLFKKTAEVNSALGARVHGTVAGSQDLAQGLFEQLRGLAESGAALPHALSERAVKVSGEVRDIIFAKEGTVQDKGQKFTAYAIDQAKPLIDEIYTLLHAAKVKAGEEGDHLAAEAQSVAEDVNTKVDGAKEDASKKADETTKKAEVAKEDASKKANGAAKEASSKTNDKVQSGAQKTAEKADKASGTVQNKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRI7</accession>
    <name>A0A1E3JRI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033494.1">
        <property type="nucleotide sequence ID" value="XM_019174442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRI7"/>
    <dbReference type="GeneID" id="30191503"/>
    <dbReference type="OrthoDB" id="2584073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="59"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="457" mass="50148" checksum="01D4E68C7A3C8C53" modified="2017-01-18" version="1">MRILAPSRRRLPRHILPASCALSYTPAARTQATTDRNEWLDFLKTETPHTPESSGKALLFAGLGSYPHTPHAPTPSSLHLWEEASEALLSPDATIGYQPIRSADQVKGGLRSWVEGRSLDDLMKRPDITTSFILASSLAILKSEQERNGYDTLLPPEITHLAGHGFIGMLTALVAAGKLDLATGVRLARIYATLPPSPPGRNRPHLTTVLSARHFHSLSSPSFSVPPPTHYATSDDDPLPPLAAKDPASGEVEVGERQGRRRAMQLILDEIHGLEPQWAEHSQEGHEEWAEAGIINSSKVVVVSGTHDAVLQVIERLQQLNLANPVMDIHMPCPYHTKLMSHAVPNFRDVLDRCYFTKKPDGPVILDTVTTKPIGNSASALLPHLTDQLRWHKTLVRLYSTPTPEVGTFYTVGRGAKGLGIMLRGELKRRLNGSAPIHIEEMGVGPRDERLVRALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRN7</accession>
    <name>A0A1E3JRN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033387.1">
        <property type="nucleotide sequence ID" value="XM_019174335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRN7"/>
    <dbReference type="GeneID" id="30191394"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73129" checksum="F651C0165E660812" modified="2017-01-18" version="1">MDSVAYGLLTRPVLKAVFPSENPISSHTPASPVSTGATSPSYTHSPTAAGPPVLHPAIEPPRAREQAPLDFPEPTLRQDIEPLAPAPEQPSPIQAPVSKDEPVESPAIEQPTEQATHTNMAVVAPQPQLDHDSALANQASGLDLNDRPVSRATQRTAPKTYHGGPGYGPWSAQSEQEPLQAQRTGPQFAGSQYGERELQNGYGGDNQVALGSALAADPSEFREEGYEEEKQQRPAFNQTPSRSYVNAVPIVTNYEPQLPAALAGNRRSVAGSTKAPSVKRASSRAGSIDGTSPVKSQSKRASRAGSVRSSKGGFNNNGVNNFAAVDHHSNGGGYEEPHAAQNISRPLSRAASTRSNRRNNFGPEAGAAGVGATAGGLYVGEYVSQEKQQQLQGANGGPRQYQDGGHQNRTTFQEPQQQYYQQQPLPGRALSPTPRPHSAYGNRGLGAINEGQNDGYANGRESRAEGHLGRSGTVLSRAGTLEERNGTLTRSGTVGSRRGAFGKGTGTSIGTQPEEVLARDDIHTRAELSERVLDEATLRRLSTMEKKDAKRLAKVIKKEAKEEAKSVQASIKELERMVKLQKEAASAERKSQLSLSKWTAREHKARLRFLKEKERYEKLEGELRNAENDYEERRDHAAGLTAQVAEKTSDLDLLRGQKAADDREREVKLLALKNPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS66</accession>
    <name>A0A1E3JS66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033567.1">
        <property type="nucleotide sequence ID" value="XM_019174515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS66"/>
    <dbReference type="GeneID" id="30191576"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="290"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="667" mass="72968" checksum="3A8B996197557632" modified="2017-01-18" version="1">MDEEADLALLDQHLLKTNQLGQRMTSILGQLDNRLYRLDKAIVPLDIESLLNYLEGKALAPSAPASAPPRPPTSRQASASSAKGYSLEPPTVKLTAPPLSPIASAAPSRSATPADDSALLMRGPDIMALGEYFTALNGVVEDLERMWKGLTEGRGGAREAGVKDLSQLVEVGFEGAVQLFLRLSKEGSGRALDVESLLNNGPPTPPNYFPPLNTVLPLTTRITSLLYPAAETPKTATVLNPSYEDAISKLAGIRGEWICRSMSSLVSKVEEADEGGIWEGHGGREKVESILRLWEVIIHVAEAETMLITTLFPNHPPPTLLAQTLARPIALAEQTLAPTLAMLKRSLAQHTFTALDLYASLLRLQPQWDHTMTQCLSRLGTPSSPATKDLISTLHQPISTLRSLSLRSFPEALVDIRSARADGPSTSAIIDISYSTITYLENLIRYEDVVEGLLGKSISERSWLMGLKDAPSNVRSADEEGGIVKFFVADVLGTLLGHLEAKSRGMRHPVGQAFLLNNSSHIRNMLIIQSNSDITGPGAEAMLNKAVRDARGQFIAEFQSLTALLTNPPHDKNQRFGVPKVPTSERHVLKEAAMAFFDRFQELESILMQDPLNRQDPEMRDSVAREAEAVVRRGYEAFVGRCQSKSAEKYLRGTPDEIERRVQAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWC8</accession>
    <name>A0A1E3JWC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033755.1">
        <property type="nucleotide sequence ID" value="XM_019173948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWC8"/>
    <dbReference type="GeneID" id="30191000"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="612" mass="67233" checksum="C862001C99F0FB74" modified="2017-01-18" version="1">MSRTGVKVNTYGKKTKTQIISIHSDHDQQSSPAVRPLAARPVLQSKLSQDNYNVYSATPLAVRTLKGEVSAKDHGTPTKLNQHLGKRDENTPIKVRVAGKANSSIFGQRKVPRKGLKPGILITPPFPSRVVKTIPSLEPPASPTVDRPVESVLTPKPATTALRAKPIVRRRLVFDGVAIPVAPGHRLANMDRLSAQMAEITITEDPSPRQEKSKGKAKATTDPVQKLVEGCIIKAVHDFTTLLRNFPLLSSSAKAAVTKVGEASYSEVFGFSSPVDTESDPLVIKIIPLLSEPGDVEGDTPMPDCSDAEDVLREIEVTKHMSNVPGGGYVQFKGAYVVEGEYPRQLLKQWDTYKSTEGSASVRPSAFPSSQKYALIALSHSGQDLEAFRFDASRGWVQAAGIFWQTAKALAEAEQWADFEHRDLHEGQILISIDPSLQPTEALNYLSPTYTSLTTTIIDFGLSRLALSPHKTPTWSSLPEELYEGKGKQWDVYRSMKDRIDGDWEGFHAITNVLWLQYILQYILTSKSLRKPRVAPAASTKARRPRAPTPEKAANEQAYEMLQQVSKVLAWSLEGAKRQGRRGAGETEEYGVDKMGDAAGIVAWGEKKGWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWN3</accession>
    <name>A0A1E3JWN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033919.1">
        <property type="nucleotide sequence ID" value="XM_019174112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWN3"/>
    <dbReference type="GeneID" id="30191169"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40486" checksum="6D4F618B165BB7EB" modified="2017-01-18" version="1">MAALEQAALDGSLFRPDHRTLSDRGDSNSDQSLSENENEDAAGDDYIDSEDDFDNTVGGRHNLKPAPPSSDPTRGQIEHNGHQTGVKGVQDEHKATQAYAREQARAGTALLQAENGLRGMQALTVHEESALVAQEAEEDEELREIRRRRREQRRRETQEDAARWERERVTDFGFGKSFEDGVKNGALREIGSMDFVDAVERDGWALVFIYEPNLPRCDDISSSLLHLKLNLPYNTTTSIYRARATFLGFSLLPPIITPESPEDIAIVSEDLDVLRREIQDISARHKKSHKNNHDSETAIIADLVEYVRTREEKKAPFMGKPDLDVLPTLLAYKDGELEKTWIRVDWEVGQDGVVGLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYA8</accession>
    <name>A0A1E3JYA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033842.1">
        <property type="nucleotide sequence ID" value="XM_019174035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYA8"/>
    <dbReference type="GeneID" id="30191089"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="261" mass="29528" checksum="DFEC711894F1AA38" modified="2017-01-18" version="1">MPAFTNSYAPPAPPDIPSDIHLHTRPDEYDFNYVFEVKQLRSDRVELRPMVPSLHAKLYFEGVTKYPEVLKWMGISPPQTLEETLVLIEKIWRTPTDSLPYAIFTEPPGSTTKVEPEDYVYAGSIAIINSSSPQMIAEPGYVTILPPFHRTHVQTHATGLLLHRILDHPDQGGLGLRRCQWLTTTLNTASQAASKRLGFHFEGELRCQKVLPAGKVGVRDGRPGVRLSECPVRHDWYSSLTWYEWEGEGRTHIDALMARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL2</accession>
    <name>A0A1E3JZL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034359.1">
        <property type="nucleotide sequence ID" value="XM_019173654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL2"/>
    <dbReference type="GeneID" id="30190704"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="338"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="641" mass="71805" checksum="698FCF5624C26B15" modified="2017-01-18" version="1">MADPTAFYEPEEDELLSQLAVPVQQYQPIGSETDEYRRLQELEQAAYAQQTMLAQAQEQEMDQMAALELVPEDVKRFLVLFHKAILDNDLPTITTMYESGWNKLTQAHYSNNEWPEAELIAPLVQNDQVFLTLYRELYFRHVYAKLQPTIDDRFQSYENICELFNYLLNSEGPVPLDLPIQWLWDMLDEFVYQFTNFSHWRSSPKAKNEEELELLAESPHIWSSYSVLNVLYSLVQKSQINEQLKAEKEGKSAEEVSEIAGEYGSKPLYRNLGYFSLICLLHVHVLLGDPTLALQTMEHVDLGGAAFLTRITACHVTTYYNVGCAYMALGRWPDAIKTFVSVLIFFIRMKQYHTRSYQYGSIAKTCERMYALLAICTTLSPGPSDENIMSIVKEHYGDQLSILQRGGAEALETFKDLYLQACPKYLNVNSPPYEDPTALAAWAENPPADATQRQLDLFVRDVKSVAGVNGMRNLLKLYTSIDAAKLAAFSETKEGQEPDGEEEVLQQLMVLKNASSTYARGSGEGSLLDGERIVTNNLDFTIDQTMVHVEETTSHRRYAGFFIRNAEHAQRALTAIKSAPLPVRKSTSNASAPSSNPAGGASTIATKPDAPALAPAATPAASVEKKPGAWVPKSKQARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZX3</accession>
    <name>A0A1E3JZX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">L198_02145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034107.1">
        <property type="nucleotide sequence ID" value="XM_019174300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZX3"/>
    <dbReference type="GeneID" id="30191358"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="564" mass="60727" checksum="1CF0C3D78E34492F" modified="2017-01-18" version="1">MASSSQSPFDDLRISLDPTTIDLALGQKRVKAIDHDGAIIYEDDESLEADLTSQLERIWNEYPGGLLDLSESKLESLPPDAIAFQPKPKPEEGQGGEGEKKRDVFKMMDWDEMERLRSEMFMQLNDARNELWFALELAKTLSVSSAHPSHPPPPPPTTLPQHQKKQPKPKATPALAAAAPPTIPGDPPILPPGTFTTTPSSLPSVPLHDTVNDLIQLVRARDDAVEECLGLVDGAVEELALMGRAGDRFWRDVRGLREGQGGRGRWAVVPKPDFARTGTMKDGEKAKDVIVPYAIDEASPATRARCIAGFDLDPTLPTSLSFPARGYRRVRVLLRDPAGTVMSSGVEAEEKAGDVREEMERAQMEAFDQDLFTQIRIEASTLDKSIIEPFQVQIQIPTSSHTLIFQLYSPPSAPSPSPSPSPSSLHSNLASTSPLCKLLLASARINLLSALRVQKQNLVAASSSSSSSSSLQQGVVGSLLEGLAFKALWEGVQNTVRSLAKALKGAGLQAEVGRDVSVSVGAGGKGEGKDTGDRGIMSVLGQVLQGNKVGEGFEVVWSLSLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZZ9</accession>
    <name>A0A1E3JZZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034544.1">
        <property type="nucleotide sequence ID" value="XM_019173839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZZ9"/>
    <dbReference type="GeneID" id="30190889"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF18">
        <property type="entry name" value="PEPTIDASE M48 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="9">
        <location>
            <begin position="396"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="639" mass="71074" checksum="6E925A3ECBC8948F" modified="2017-01-18" version="1">MLRPLSTRPLVPLSSRRPGMHPGVTRRPLPPPSRLRAFHATARREVIPLIPVAGLAMFKGASLLTVATVFSRILISFFPVGTLAAFKMIRADKWMDSEIVRPSVGPPAEDFYRMWCEGEQAVRVPMEETDRLIDVEPGHLGGLTLADGRVAYPVPMPPRSRHTGFKSRTGPHYTPQALMEHSNGNRKHVAWWIRRGYFIIPPLPPSAEPYYKSLPQKDREEVDSLRRYWIGLKFFKDCFVAGRILLALVFGLPFLLICTAYIAGLERVPLTGRWRLILLTPEEEDAISTSLGGGNWYRSVVNLLTTAEHPAPPIVPTNDWRWAWVQGILTRLEEAALSECRYTPNTSLAPSDPDSLPIPPPTYHPFTPRPRASSLLHSVLPGGDPSTGREHLEIGPPYNIMLMQKDEENAFSYGFGGKRAGGIVVYTGLLDHILVSHDPSPVSAQPSQTGLLRGLFGSRSPPPTKPTPEQDLHLACVLAHEMGHLLLSHHLETLSQQQVLWPSVLGLSMDLIRAFIWPFTFFLGPTVNDALANVGRTGTEELSQKYGEIGFQWKHEYEADLAGLRLLARAGFNPHSALSHFSSSVASLQEIQPIDKADDGLTGAVFKLWSRATHPSAGDRSEAIRKEIERWEQERMGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K054</accession>
    <name>A0A1E3K054_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034503.1">
        <property type="nucleotide sequence ID" value="XM_019173798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K054"/>
    <dbReference type="GeneID" id="30190848"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="110" mass="11641" checksum="276FB2946D33A282" modified="2017-01-18" version="1">MARPDPYYNIPVSGCASSAELAAQFETKRSLAGSHLQRTEMVVDPGAVGRGIEVATGYPRPLPSNSCGALSSPRHSATPHSPAPLRCELSVALETVLHRARGFKVDDRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0A8</accession>
    <name>A0A1E3K0A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034553.1">
        <property type="nucleotide sequence ID" value="XM_019173848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0A8"/>
    <dbReference type="GeneID" id="30190898"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="227" mass="26296" checksum="A2827738B5D9C651" modified="2017-01-18" version="1">MAQVVTNLDQPSTYRDNRSEIDRETERRLLAQSTTLYVGNLSFYTTEAQMYQLFATCSLPELGGGIKRIIMGLDRNTKTPCGFAFVEYFLHEEAVNCLRYISGTKLDERVVRCDLDPGYKEGRQFGRGRSGGQVRDEFRQEYDSGRGGWGHQRLEEERRRQEQDQLRSQMQFDTYAAVGGLGMAGADVPRGEEFFADRTKRDRSEEEDEDLERREDEKRLRGENDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1P1</accession>
    <name>A0A1E3K1P1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034457.1">
        <property type="nucleotide sequence ID" value="XM_019173752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190802"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="571"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1327" mass="144297" checksum="0AA55C3087B9DBB1" modified="2017-01-18" version="1">MFGNSIASSSTPSKPTSPSTALPARPPPRSSRRQMPSSAAMFVFAMVVPMVAANPIPIDSQTRPRLRISPSSIAALLPPNLPSPPSMSSFPLVHLFSATGESLARRTNVTGPILDVALYDPSSQAYRLPDNYIKLNQHLTPGYIVLSYAIAFVGSLCTLELLIRRTTNSGWRNQVLLTAAGICFGAVSTFAMHFIFNNALVLKHPIHSEYPDIYLAYNAGFTVLSLVVSCLAMTFAFYVMGTKFSDWSFKKSAKKSSRGRIKRGSDNRASIDADEYREWKSTHRKVLRRGTIGPGIPPRGGSQSNWSALEPESYSQRPSIKDRMIFGSRMRSGWKDDLGNMYGERDKDLRELEFRLGKVAVERELAKRANGDREDTHDDCHPPSRRPSLILAHDFAGQRPSSRRGSTIFTPGFNFPSSTFTQTHHEDPGPLRPASPDTPFPSSARLEWRRSSLPTDMLSSQRIERPFPGHTDLARILSLPEGDVDPNLSTSPDRSHASQGSQSEDEGKGSLEDDVTELNHEKSNYDGYIKKKKANMVDKNGVWGKLGVILGFDVVTLGEVVKIFVTGAVAGFGVVGMHYIGQASIIGIPYVAYRPGYVVGSVVIACGAVIIALYIMFIMLRPKLKHTWWSKILVALILTVAVCAMHFCGMMGTIYAWPRDKGTSKHSQLTGTNAAITGVVAALAFTACIACAVFFVLHSLHQRREQARRRRVVVASVMFDDRDRILVSSTDGMLPMCDIANLTGGVHSSSGKASFIQSMTSDSTVLGLDLSTGHEAFVSALKLSWLWKSPAGSHMSASGSIDGKSQTQSENNFAATLADIRRGSMGTSNITTTATGSRAVPISITKFLEKFSISAGQLALRLTGQMNGITRLGVLYDQILTTGWVKLENSTDTVSKGQLIFLVRRVTSAAERFDLQSRHFMFAEPAAVASALHRTLSVPYDHIMPLLSDIRTFCDSTVHCTIQPGKLYAGVAVVQATPFDGLRILLEKDNRSQLPMREICTLGAPPSEEEGLSGTAEEMGEALSLLQGLTMLSVITRHVELDIDATDQALSQRVNALLAALERAIVPMLDDILTGEDMIHILPRLSLHPILIPLTPGGRQLATLPGKRSAYTPPYTIVFYANYDAAVNTFTDQWLPFGLFRAQSSCVTAQKVQVGQRMEKIWAETDEESGHAPGRRPSKVQFDFPSHSGGQSSSTAASSSGPAFDNNLFNGFSFTPKTEDGVDGGNPDTVQRRSSLKQSTFVPTQVRKNSSVPSRVNSVASSSDGPSGGSTTGTLGLGIRDVNMGLGTAEGPSMAKEIVMRQVLPGVGLWDQDWLLNLLRSKLRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1P2</accession>
    <name>A0A1E3K1P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034212.1">
        <property type="nucleotide sequence ID" value="XM_019173507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1P2"/>
    <dbReference type="GeneID" id="30190557"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="345" mass="36596" checksum="E2C6EE2576703E87" modified="2017-01-18" version="1">MATPLPSLSPAESSYIAASLAHPAEPTRNDGRALFASRPIQVSYNVFPHANGSARITLGGTEVVAGVRLEVVDATGEQIKGQEVWKTKVTVDITPQAFPNTSSSIINNLSTHFQALLTSHFAPSLPALPILPNKKYFQPHLHLTLLSSAGNVPTALSIAARAAFSGLRVPKTKVISWVGEPGEEEGAEVAKGDMSGIKAAIAGSKTKGKGKLVVKGNEDWDLDMEDGDGVAYLEGREQLPVLVALNIASLSYLFFSHLADTLQVPNSANIFLDATAQEEAACPTRILLFFKPTSPDSSSAPNLCGMRLEGPHGLDQSRVRGLLEQGASVAEELVKELNRSIPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2B3</accession>
    <name>A0A1E3K2B3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034452.1">
        <property type="nucleotide sequence ID" value="XM_019173747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190797"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="377"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1652"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1729" mass="192648" checksum="F0D92BA4140548DD" modified="2017-01-18" version="1">MTTNSPDLSASAPSKEDQYRQLRRPPSQSRLSSLMVPGRSRSGSTASQNSVNVEDGGATGRITPEGRRRAGKAATTSLLANDAKYKKFRYQVDKSLQSFESINEWADFISFLSRLLKTLQSQSPPYNEIPRKLIVGKRLAQCLNPALPSGVHQRALDVYAYIFSIIGVDGLERDLTIWSSGLFPFFQYAATSVRPLLINIYETYYLPLQVQLRPATKAFILALLPGIEEESGDFFDKILFLLDRLSGAVTPTFFLQNTFLILITSSTSRLSALNYLSRRMLKPPDHPEATVETGLLIRGFAAVLGDDNMLVRRSGLELLLRVLKLDSGVYKSATDKDKELLMRAVTDVVLQKELSLSRRVYTWLLGPGDTPTDQLRFFKSHGLDLLASTVLTDMLELETQKDRSDNENGPDLQRPFKVFLSLLDKWEVGVALSRKVTINALRIVRRAQLEGTPGASDTASALYDAVEPTVIWKDLSTAVIDEVSGGEAHDLELILWLLRNVPQTDEEVTNIHVPSLLQCLLAEDRKNAALSLAVHLIETVPTTILTRSSTTIDWASDSPPVSQVLYSEDRLPETIESRIQAETLPSIIDDAFAINMSTIDATDTTFLLNSIRLVSALIESETPSLALVDGSSWLSAVVRGLNKVSTFVVVESLVCVALKASRCAFIQPPLDLTSETNMFAFLDSLFRYLRPSASLYHSRAVELLWDFNQLAEIHTLENVIARRMAQRPFNSSAFEAFGVFWRLTDDSMLPGEIFNVPICAVLDSLNSSDPNIQRHAETWLRLNLRSYLRVVDPIMSRLIDPVIKYNSSKGVYDGPVDLGRITYYIEAIATLFQFGGQGLSKTFAAQEFGSSLHSTFVHRAEGQFPEIKTYLELLVMILIRFLETEEDSRRGNTQPLVVRLQGAALSLLQTVVSRGDVPYPLLNDLKAKLVENLISAVQKGHLTLQSKMLHLLHSAIHASAPRRDHPSRVASHTHRRAASSIFEKPPPLEISPSEFEYQLVVMIMRGVVTPSNIPVLQHWVDFVLMTVPTLASRPALLHTLVECFSQETRELVQRMRDAHEKASGHRDEVIHDETLSVTDAEVVMTLNALERVLTLLGNQALGRADETPNPQTESGSRILGLVSNVFTVEAPSIDPKAESPRYLDDAIHALLVTWSATLPPQTSDALNYAPYEVIHSRAKRVLEKAFTAQPLAVMSSCVHVWSLCSEQVSDTAIFDCIDALTPSAQKVLELTCELASGKTGRMIPDYRVDPSYLAFLEAYVSRLEAPIAVQIWSTLFSFARDVAGGVTSSSSRAQLYPTLQCLTNVCLTISKTTALEDRRLRRDVQDIYVKLLDLVVSNVSKIAEGGIWDRTTMAKEDSEEDTNVEKGLEQIFDYLSSTIIPNLRALLVEADRVNSACSGIAVSIIAPAFRQQKVDVPILRLVLQLSHIPSATKTWRSYISDSFGDSRLFKTKPPIEVAYWKALVLALFDADKERFPDLLSRITSASSANINIFTNREQEMLVKCGNLRRLSLLLLSAERNHYLGQLPGIQERLVEMLRSSSLSARVHSDVYLCLRILMCRISPQHLANFWPVILAELLRIFEQTLDEPPENNSEDLQLVLAACKFLDLLLVIHHQWMFVTDTTDAAYPPEEFVPESIMDRLADVLSELDNKPSPNLSQEELVPLASPTTQGPAPLRRPRLSGVKTMTSLHQLQPFLARASMDTFESVYGDYGVDWDGIEESLTGEIFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2H7</accession>
    <name>A0A1E3K2H7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STE/STE7/MEK1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034673.1">
        <property type="nucleotide sequence ID" value="XM_019172947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2H7"/>
    <dbReference type="GeneID" id="30189988"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="154"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="469" mass="51630" checksum="6C788485B73D5A1C" modified="2017-01-18" version="1">MVTLDPPSSSTASVAITSPNSTPTPTQQSTFSLPKSTISRKKPPGLDISKSILRPTRSAPGLPPNGDSPVGNFVSEADKLRDDIAQLQLSSRSTGSHRSDDEAEAAGLQSDDSAASGAHKKEKKDSKSGKDGKEKKRRRHKDKNGEDLVKEEDLDNIEDLGAGNGGTVAKVWNKKRKCIMAKKLVMVDAKPSIRKQILRELQIMNDCDSPYIVGYYGCFPVDVHVGIVMEFMDAGSLDHIYRKNGPIDIGIVGKCAEAVVRGLMYLYDEHRIIHRDIKPSNILVNTKGEVKICDFGVSGELINSIANTFVGTSTYMSPERIQGTNYTIKSDIWSLAISIIELATGRFPFSDNPDADDLSPTASDFDPDPTLPRSAQRPQVDKKERVSVAPAYNMSILDLLQYIVNEPAPKLASRRFKFPEEAVEWVDDCLIKDPDFRPGPKELLAMDWVANSKVTQDDLRSWAQSLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2M9</accession>
    <name>A0A1E3K2M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microsomal epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034867.1">
        <property type="nucleotide sequence ID" value="XM_019173141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2M9"/>
    <dbReference type="GeneID" id="30190182"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="407" mass="46067" checksum="F7091CB3A68878BF" modified="2017-01-18" version="1">MSYATLPHQPTIPICPFSVSIPDSDIQDLHSLLKSTRIAKQSYENADSAAKENNFGLSREWLVNMRDEWLNYDWRKEEARINSFPAYIATLKNKDGLDYDIHFTGLFSQKKDAVPIILSHGWPGTFLEFLPILERVREQYTPEALPYHLVVTSLPGWIFSSPPTQDREFGVKDVGYLWNELMVGLGFGDGYMSQGGDIGSYVTMELGSTYDQCKAIHLNYRHVLHSVPPDAPPSDISLPPPPSTERLFELFQNFGYFFQHATRPSTIGLVAGSNPLSLLAWIGEKYVSWTDETPGVDTILAFASLYWFTDCISTSLYTYRYGAGIKRKESRAEQKYQSCPTGFSFFPKEFIPVTFDVVKASNNLVWYKQHDAGGHFAALEKPDVLWADIEDFVGTQWEGCSKKTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N2</accession>
    <name>A0A1E3K2N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="2">EF-Ts</shortName>
            <shortName evidence="2">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TSF1</name>
        <name evidence="3" type="ORF">L198_00822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034720.1">
        <property type="nucleotide sequence ID" value="XM_019172994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2N2"/>
    <dbReference type="GeneID" id="30190035"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="360" mass="38121" checksum="16492753211A3DAC" modified="2017-01-18" version="1">MLGLLPKSSLRTAISRSLHTTPARLAEGKTKVPVSLIAALRKSHPVPLAAAREALERSNLDLEAALDYLRTTTSASAEKKAAKVSGRDTNEGVITISLLGGKRVGMVHLGCETDFVARNDVFLKTARGVAETTAFLDVPGEHEKPKLLSNSASIPDPILEFPTESLLSAPVISLPSDTSSDNIAPIPTSEPTTIKQSLLSSLSQTGENLRLLRAVSFAAPFPSTPTVRFVPGGYAHGGSSDKEGKVGGVVVLAVTGAEADKPIASIIHGPGGDALEKSLESLARTVARQVVGFPTKAIERGDRAVEDEEVLMEQAFMMFQGDSRSVKEVLAEWGKEKGVVVKVVGMRRWSVGDELETIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K548</accession>
    <name>A0A1E3K548_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase pc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034849.1">
        <property type="nucleotide sequence ID" value="XM_019173123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K548"/>
    <dbReference type="GeneID" id="30190164"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="567" mass="63985" checksum="7B16F31B0CC725B5" modified="2017-01-18" version="1">MKGARFLLPALAKTLFLPPLIVFLLFRALPFVPLALEVVAYISSFPVLFILRSQLSAELSARSARQLKAVDIPRVQGRWPLNLDVLWDWAKSGSEEEVGRMMVLMERRYGGTYNTRVLGEDQIMTTDPRVFRHVLIGDFDNFVKGQKFKDRAQEFLGDGIFNSDGQMWRHHRSLLRPFFHPTSIRPSRFSGIIDDYISSIQPGKPFDMQAELGQLSLRMSIMWLCGTDLTPELGEDHIAEWKDAQTNIGQAMSDAQRVVGKRVKIGTLWPLFELAGDPLKKPLKIIRTFFGPIISQALERKEKLSNAKDDSSYLLIDRLVHAIDNRKDIEDQLINILLASRDTLASLLTFCVYALAIHPEIALKVRDEVVSVCGLQGEITKDQTREMRYNRAFINEALRLFPPVPLNIRRTLRPSILPTPIPSYMPANTSIILATILMQRDPKVWGEDAQVFEPDRWINGSELQREGFTSWNIGPRMCLGQPFALTAAHSFIAHFSRHLSTANATLRLSPEAQPPGSTIPDSWKSEDGGDGRLRGGRDKVWIVADVVLAVKGGLWVVAEPDEKARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K611</accession>
    <name>A0A1E3K611_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035160.1">
        <property type="nucleotide sequence ID" value="XM_019172218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K611"/>
    <dbReference type="GeneID" id="30189241"/>
    <dbReference type="OrthoDB" id="2596802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="88263" checksum="7F5A39CD47F2A4B5" modified="2017-01-18" version="1">MLARNALANAQSAYPRCVPLTRALTTTPLLRRVDKTNTPWDASSSQRKGPNSFRNDARPGDRRPPFVPFRQPGKPIRMPAKHFNMPGIGDASPLTPESIASWIRSFPLDRLEYDREKLNMNTRMATPSTYVLWDTIPGKGIRVVYDQTLNERLYASLKSKLESLEGNVVTPDMEEDLRVGRRDARSTTVRSEHDLCDVMLTNFFKRCTDAINAGLPGHLHGEWQRCSDDKSGSSAWEFRRDDKTIAIVEIKLRTVLTTAGEGAVSQTGMELRERPQGDTAGRGGTQSGVSHSDQSQADKNVPDDEQKPDDLPPKLEQLLMACRQEGGLKLILADRKSEDGRVRPALRIVDQEGKIVKKMTHWADGLSQVWKDLDHYELDLVTLSSYEVWIPFERDPVIKNLLRVGDPIHRKEPGTAPEPGKMSPMELVVASVIEREPAPPFDYTFSPLPVWSSSEASGNDSTQNDQNESGVGASELRGTKSGYDNVGATGGAGSDDAIDRDANIPTDQLAPVTLQVSVPNHRSRDALHYFKQRNLDNGYMAGRLSPCVIASSADDDNIHSGLPTSELKAHLALGSYISSGRLWDVYHSVLTVEGRVSKKLIAKVMCPDTYDEEYGGHKEFFEGPEEAVAAYRLEAALYSGPLKSLQGGAVPAKYGSFSGVMRIGRIPFPLHIELMEDVGGSVAGEDELEYLPLQDRQAIRDLYHQIHAVRVLHCDVEARHILRRADGRFALIDFDASFLVGDGVKGDRELALEGREVAVMLGLSDLVARKAESRAGRRHLQREEVVVDPGAVGRGMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6H9</accession>
    <name>A0A1E3K6H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial dicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035526.1">
        <property type="nucleotide sequence ID" value="XM_019172584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6H9"/>
    <dbReference type="GeneID" id="30189616"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="98"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="31962" checksum="D4F3CEB0798BA53E" modified="2017-01-18" version="1">MAAPQQKYPFCGCLLYASSRCDESVGLHHSNTVRGSERIIAYMAVKGVVKHDGVRGLYTGLTASIFRQMTYSVTRLGVYDLMKNQMSNNGQKKLTTGDMVICASTAGALGGVAGNPADIILVRMVADPTKPLEHQLHYRNAIHGLYKMVANEGPASLARGLAPNTIRATLMNASQLVSYDFFKDHILAAGIMENGMPLHFVSSALSGTVATTICAPADVVKSRIMNMKPGAGQGPITLLTESLKLEGPRFLFKGWLPAWIRLTPNTICMFVFLEQIRGAIDLFRNKSSGVVDSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T8</accession>
    <name>A0A1E3K6T8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035654.1">
        <property type="nucleotide sequence ID" value="XM_019172712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T8"/>
    <dbReference type="GeneID" id="30189745"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="542" mass="57851" checksum="3E57B8B9482FD66E" modified="2017-01-18" version="1">MPGDLSFLDQLEDWLEAQIPNNIHHLPHKMYDTVEKMTGELLDSLNIHGPPSISIPFPPFGGKDAPPPPPPPSSAVSCAHSVADRSGRVLKNHPYAVGAALSVGLGLTGLMVYKGVGVFGNDWRIKRRFGVRGAVEDGMLKEAIVILAPSPLPPLLVPLAASLLRSGYIVLVAVTNNRDAQSLERRLSSLEERAALRVLIYDPDDSTTFPPFHRSLLATLTLRFPVTGKYAAGDPYNPQPTQLAHIHAFLSLYPLHPDPPSQPGALPAMPTLVAPNANGSLPLLVNFYPSGSVPTTPNTFASQVLTSNHLLLGKNLAASSPGARVVSVYVGDIDLPTLPAILSHGKTLTRRQLAKERLAQDSTPKQKVSVIGDYLFGTLRAVFGTIIGTVGLGSTVREYATFEKSILRIIKSSYGHDHFVGQRSMFPLLLSQLPIPGYLLPSLLTYLPSLPSPTGPPLPDHPKATRSKHAARPASRDADSERESEKTSAEEGSEHESTGEDLVSSIHTGTSLGSERGMDSESSEGAGSSGLEGSWVGLDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6U3</accession>
    <name>A0A1E3K6U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035570.1">
        <property type="nucleotide sequence ID" value="XM_019172628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6U3"/>
    <dbReference type="GeneID" id="30189661"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO08715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16736" checksum="BFD96AE0CA3BBEA2" modified="2017-01-18" version="1">MDDASDLWSVKKNEEAAAKKRPKVTAAQLRVQKDLTELDLPSTMKTVFPDPTDVLNFTLTITPDEGIYKGGVFNFSFAIKPEYPHEPPKVRCKEKIYHPNLDLEGNVCLNILREDWKPVLTLSSVMIGIQYLFLEPQVSFTDATDHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9A8</accession>
    <name>A0A1E3K9A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035687.1">
        <property type="nucleotide sequence ID" value="XM_019172745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9A8"/>
    <dbReference type="GeneID" id="30189778"/>
    <dbReference type="OrthoDB" id="3267861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="583" mass="65557" checksum="F3E54D35C7E3F322" modified="2017-01-18" version="1">MSSSMFGSVGSHRNRRKELRALLRHSGMPSLFVTLNPADSKNFVVSVMAGRDVDLDERLGLSDELKEEVSQRFSAASADHGACAEGFHFMVEKFINVFLPYGSPEALHIHMLIWLEHAPSPLELRKHEKENPEWAAEVCRWLDTVMSGSLPEGAVPSGRYPPCDDDALAFRQRGDHRSLPLLQPPPHLPPHMSEEDWQRVRQDVMEVLECGQLHDHSFTCFKHLPKLRRAQKLGDADCRFKFPKEEVLHTHFNDDGTIDVQRTHPKLNMYNLIMVGAFRCNMDIKFVGSGMMAMAAVYYISNYISKVALDTPTMFAAIEARFRRGNGRLLGQEAERVGETGAEARQRQMKSLLVRSCNTLTGKQELSSEQVMHHLLGYPHRYTNARFQNVKWWDIARHLGLSNSKLAPATRGSQGSEDVPVEADRLEESLDLDEMPRPTGGDVEQTVTLLRMGNPDDELRHSGGSYAVDDYIRRPNSLSSVCYWDFVARYQKLTAKSARKKGPQKAAPEFLPSHPQFSAHRIQTRRTPVVPILSGPTIPRDSAASAEEHARTMLALFKPWRSPADLVPADGSTSKELSSCVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9U1</accession>
    <name>A0A1E3H9U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000068">
        <property type="protein sequence ID" value="ODN73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027758.1">
        <property type="nucleotide sequence ID" value="XM_019180264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9U1"/>
    <dbReference type="GeneID" id="30197509"/>
    <dbReference type="OrthoDB" id="2577060at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="475" mass="51651" checksum="E550510416F9E0AA" modified="2017-01-18" version="1">MADPGPSTNTGEPTPAPQPVQQTPASINALSEIFGFINHPDAAATAARAGSTQRKGTKASARLKGKAPAVPPPSKSSVPNAYPAGLGHSANQGLGGPLALVPFDLTIHHRYPNGLTIKPYKDVDQDWMGSVWTSCYHKIPGEPGFQADHVVLYLREFCFPPKTVYKTSWRTDVDFSQDSFYLEKEYTDLEIVQSVRDHDTEVKGSKLSSLGTSKAASVLSMKLGATKPDVCLTGYHNGNLAEETCRKEPAGGGNLEDTDRPLEALYAIIELKWVPWPGESRLNLRNLDLHLNDLDYANMEAITQTIFYSLLGYDVSKCRSAMALVNGDYTRIMNLSDLVPEGEEAVLGGMTLGGGGGRRILVEADPDVVNKLRYHKVPCLSPEQFGELAAGVSSLGIQWKAPNSLIANYENWALDVEAKERLDATVYLNLALATHHPEAVQDSRISNHPLTNVIGANTSKKEAYQWLDVGVKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF37</accession>
    <name>A0A1E3HF37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Minor histocompatibility antigen H13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08188</name>
        <name evidence="11" type="ORF">L198_08203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000057">
        <property type="protein sequence ID" value="ODN74937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000057">
        <property type="protein sequence ID" value="ODN74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027846.1">
        <property type="nucleotide sequence ID" value="XM_019180159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027861.1">
        <property type="nucleotide sequence ID" value="XM_019180174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF37"/>
    <dbReference type="GeneID" id="30197399"/>
    <dbReference type="GeneID" id="30197414"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN74937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="46574" checksum="53C295F466B8C481" modified="2017-01-18" version="1">MAQDPSLWVTGTSLGLQALVPIVIGSYKSLKTPEDTKRRLRNAQKGKIPLESDEDEDDGLEEPLTWWDSLLFPVIGSVVLLGFYGIVKYYGTEWLNRFMNAYFSIAGVFAIQSTFSTILSFLLSALGVTSTIYHVRVSSGFRQIFHLPVTLSSLFLIPVAISIPAAYIYFGKPYILSNILALSLSTETLGLLKLDSFATGFMLLGALLVYDVFWVFATPVMVTVAKTIDAPIKILSPKTSPFASPTKFSMLGLGDIVVPGLIIALCLRYDLYRYAQAHKGQNVTPKSKFGRGYFNVAVLSYVLGLGVTMAAMGWSGRAQPALLYLSPACTLGPLLYAAVRGELSQLWAYSESSKTPEDQKLLDSTIEAASEAAIKARAEAKAAEAEATVAANGLDEKAEQKAEDDSWMNDGAGVGTSEAKPKKKKGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HL78</accession>
    <name>A0A1E3HL78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027981.1">
        <property type="nucleotide sequence ID" value="XM_019180034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HL78"/>
    <dbReference type="GeneID" id="30197272"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="92"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN76466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="68343" checksum="64FE468D4306539C" modified="2017-01-18" version="1">MAGFRDLKNARQSRHKTSYGISSSTPKAPISPPSQQSEETTQDPIDASTLTPSRLKPTSESTSASTKTEIPKMAEGKKSEISSLYADELKNASLEVWDIPGRGRGLVAGKKFKPGSRILKTPTATSVLSTPHLTTTCHGCFLTPSEKKIILASSGKGIDSAGANVKLNRCSGCKTLHYCSRECQLTDWPSHKSECKALSRLRTMYHLTYPSRQSDASDVRWAGADAIRALGRICWTRRSKLVERDGGDWWTRLEGMESHVKQMQPEEAMKLGNQTQHLAHYLSASDPLQPDSDPSLLEPADMQTYGFNSVAEVIHLCSAMKVNAFTLTSPSLTPIGISISPLLALANHSCAPNAVAVFPRGGGEIDLVAISDIAPGSETSQRRTTSANPNCSTATVSPVTVLYASSPNAGKEEEEGMKNGWTLGGVSGTLGAGRKVLGGYLVAITSTGKVGTKCNSCGDKFDVDNDALKALIQQGYELLEKEENGTLDPSPALQTLSTLLPQLLSLSPPSSHPLLALLHLSALLLSPPKSPSSLSLATQHLALASSASFLSLPPNHPSTAVTLAKWGKLLSLDQVRLPSEGPEGAEMLVKRLEMATVVLRKALTAAELGFGAEGGVVGLEMDGLVKGCEGELGVYRAKKRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRW6</accession>
    <name>A0A1E3HRW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028075.1">
        <property type="nucleotide sequence ID" value="XM_019179953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRW6"/>
    <dbReference type="GeneID" id="30197191"/>
    <dbReference type="OrthoDB" id="10351347at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN78191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="425" mass="46886" checksum="16F5862F6154FC9C" modified="2017-01-18" version="1">MVGTNSKQNTGEEEGLLSGDWTEGYRNPNVIITDGQRGNKRERGEVGRGLRSQVADSQDDDRKAYTPVQVDPPSLTPGAPSGSAYPPPATTEQMISQWVDAQVTYSEIWPSRQRVIYAVLSLYCIIAEIASAVTLGEWGWGVFLLWIATSLLFLWRHRGVMKGRAAALESVNLVAERMRSLMYTAEESRDIQILEFLEIKSFLSKLIPHKTDLSSDKYISPPPFSPIPPSIFLFANNHKCQSDAAVGLGISILPFFAVFTFQLGLILGNLHGEDGIGVAIIIGFISELILIFSLLQYVYHDPHGHLCGGLDKDGAKLQWAWHKKHFQWWGTKAVKDVLQPDAISSLKKATAPHNESNPSSSTTTAPAGYVSSLSIDVLLQELQKRMEDGNVVAELQRRMNEGDVARRAYMALSGTNSNQSPPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5J5</accession>
    <name>A0A1E3I5J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028359.1">
        <property type="nucleotide sequence ID" value="XM_019179671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5J5"/>
    <dbReference type="GeneID" id="30196894"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="464" mass="51988" checksum="13411667CB0A5B54" modified="2017-01-18" version="1">MADEESRILQRFKDKEAASIKSTKFPKHFSEKVDLRKVNIAVLRPWIAEKVTELIKIEDDIVVEYAFGMLEDRENPTPDPKKMQVSLIGFMDKFGAAAFMDQLWKLLLSAQKTVGGVPAEFIEAKKAELQKRQQEESSRGPPARPQAADYFDGPPASGGGGDRRYPDRRDVPPPRYRDEYPRDGGGGGYRGDRGDGGWGSGRGGGCGRGGYGGRGGRDDGYGRRGGGGREFENRPRDNGYGNRGAPGPGPRDRSRSPARNTGYDKPPPRDFDRRPPPHRRSPSPHRRRRPTPPSRPSPPRRGRDSATPPLRGGAERGRSRSITPLSKGRSPSPPPRRRRSLSASRSRSRSPPRRRRPSYTPSPSRSRSPPRRRAPPPKRRSPSVSRSRSGSRTRSHSPPPKRRRDYTPTPSRSPSPRPRRRSPSPRRPRDRSLSRSRTRSRSRSRTPERRGSKGMSIKGKGRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICZ4</accession>
    <name>A0A1E3ICZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028692.1">
        <property type="nucleotide sequence ID" value="XM_019179336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICZ4"/>
    <dbReference type="GeneID" id="30196544"/>
    <dbReference type="OrthoDB" id="10309602at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="71" mass="8234" checksum="6894236748A5C72F" modified="2017-01-18" version="1">MWAASIPVIFVVRYLDRRQKRIDQKSTITDEPRNDGVSDIESQYASDEDLPKREVVAVPVSQAMWEQLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDZ9</accession>
    <name>A0A1E3IDZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028836.1">
        <property type="nucleotide sequence ID" value="XM_019179219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDZ9"/>
    <dbReference type="GeneID" id="30196419"/>
    <dbReference type="OrthoDB" id="10424559at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25768" checksum="47E90A8CBF82D8C6" modified="2017-01-18" version="1">MPSLGTTLPSPIPGAPALPPADAPASTYPPTGPAVERRRSSSIKHPHPHAHPHPVVGHAAGSYPPPPRKPLTPTGYVPAFESDDEMFKERYIALQLLINELEDENNLIAYRIAKEESRMRQLGLPLPNYAFSGPPNPAPVPEVGAQGALPAGDVPRGREGELSARGTASNGVSEREREEPRGVLPESGRVVSEKEFVEGSVPRHEQPFDQPNGTKRRRESGDIDSFPEKINIVANFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGN8</accession>
    <name>A0A1E3IGN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029096.1">
        <property type="nucleotide sequence ID" value="XM_019179002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGN8"/>
    <dbReference type="GeneID" id="30196195"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN87753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="42127" checksum="E185C84575AAB74E" modified="2017-01-18" version="1">MAPLLTEEESAIDPYAILGLDVDATAKDVQKAYRKKSLLYHPDKNPAPEAIATFRQVSLAVGILKDQNKKSYLDTRLEDDRKKKARYAEMDKKRKKMVDDLVEREEQAKKARVEQQHRRRQEAEEESIKDAGKRMLEEAQKKAMAAAAATVAPSPAPTPSTEKAASNGESGPDITPECLTLIFILPSTSTVSQPQLLKSLTTSYGAVNHLILPDPLPSTPAILVEGTKKKKTKSRKAVVEFAKGNWGGCYSCCRDVEDGKVGKLGVEGVKVKWAVGEAPSWVAWAETQLPSRRKPSDATAASFSFPLPSPSSAATPPSFTSAPVFSPSTSMADLLASHAKERSSKDDVRRRREEAESMTLSRMRMMEREKLEAEIKRQEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGX9</accession>
    <name>A0A1E3IGX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029018.1">
        <property type="nucleotide sequence ID" value="XM_019178924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGX9"/>
    <dbReference type="GeneID" id="30196109"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine</name>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038896-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="379" mass="40548" checksum="38A9F029FD160996" modified="2017-01-18" version="1">MMTVKDPTRAQAKTLIPHIPNPDFGKSLNENGKAGELKATWLGHASVLVEFPTAPTFPGPTGGLTSTAGAQSVQGGVGTAGLGEGGKRGVRVLFDPVLGEGMAFWGLGPKRESSNPFKIASLPQIDIIAVSHNHYDHLDLPTLSSVFKSQKEKYGSEPVLFLPLNNRHVVADLDIGGKGGKGGKEGERGRVIELDWWEGGRVVVDGVGEVEMTCTPCQHTSARYLWDRDNSLWSSWVAKDVRPGVTNPTSVFFGGDTGYCALHSHPNPFHLPPPPSLPYCPAFKSIGDKLGPFTLGLIPIGAYFPTESMSGMHASPGDSVRIFQDTKCKQALGIHWGTFRMTPERFTEPPEMLAAAVREAGLDDGVFGVCAIGETKGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHI4</accession>
    <name>A0A1E3IHI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029128.1">
        <property type="nucleotide sequence ID" value="XM_019178851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHI4"/>
    <dbReference type="GeneID" id="30196020"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18150" checksum="7E25F4B67A78788D" modified="2017-01-18" version="1">MSKTVLITGANRGVGRALTKFYLEKAWRVVAAARNPTKVSQEDKVVIVKIDSSSPTDAQEAVEELKSKPGITHLDLVIANAASSQNSAPLVSSSVSTDLITNVSGPIALYQATRSLLTDEDAFVAITSTAGSVTGDWGPSLGAYGATKIALNFIIRGIHIEEPKLKAFAINPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHK8</accession>
    <name>A0A1E3IHK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029147.1">
        <property type="nucleotide sequence ID" value="XM_019178870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHK8"/>
    <dbReference type="GeneID" id="30196048"/>
    <dbReference type="OrthoDB" id="10452253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="644" mass="69057" checksum="5DA7FE0261D54F58" modified="2017-01-18" version="1">MEVLHMSFHMDEVGKKRVYDHPATYEEMRVPGGPELESFPEFISGTAAKKVKSTPQAGSSAMGALESLGDQQYHAGPSSLGAYYPPNPVHPYNQPGQPQQPLAGPNSHHWTSLLYPSTSVHPHTVPAMPAQSPVFGYHRPVPTQARQQLPPSMTGGHTLQRAQSHGQLDANLPPVVSAAAAQHQMMVPSDFEEGFGGPRTRRLSRQEARDKDRRFSEKYQQMSQLQQLYPDFTPGQPSYSGLPNHIQPGFGSRLVVHQDLYGAVQAGNIHGPSNANQRIYGGRSAQVGSNDAVHLSQEGSAQAGSSINTAYDLETLYDGSFVHAGGSNTTDDAGQDQYLGSSYPQVNPFANQNLHRGSSSSQIGINNNVPFESQSLYGGSATHTGNDNTASYTLHALPGPSSGMCQPAPGAEYQDISPITNFTSNVDSIPSPPPLTPSSSSSGANIPQQHRNLTPEEMSNLLRCIDMSPSATAEEMFQTIDSPEVCMNPRAVQHSYPYGVARPSVNFGIQHPPGLLSVAPAGHDIVQQRNVLEGHIDPRLVQQTCDIIAQGISNFGSHQPNLPDATAGQHLPQQQPMANPEGCMDPRDMHLSYSDGVHGAPEFGPPPFDLESLVVPHDDGCLKGDDEGSCSVAADPDAGLPLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II51</accession>
    <name>A0A1E3II51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBA/TS-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029173.1">
        <property type="nucleotide sequence ID" value="XM_019178896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196080"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1467" mass="152042" checksum="24975E28DE39272F" modified="2017-01-18" version="1">MATYAPHERAYYDALFAFLDKEGTSVLPGQDVYPFLTSSALPTNTLGEIWALSDPDNNGFLTKDGWYRAARLIGWLQNGAAKSVDEDLLSKAGPLPTFPTGPKPSAQPPLQGQTTGQPLSANVTGGGFPPISPADRAKFTRLFAGAGPANGLLSGDKARDMFVKSGLSYEKLGKIWQVFAILNNRGSLDLTDWIIGMHLIQSAMVNPSLDLPLTLPPGAYEAASGGRSAPPVAPVSPLRGNTASPVRPQYTGGIAPLQQQGIAPLQQQGTGGSARAPQRQMTGSTFSPARQASGASQPWDVTPQAKATSDQFFSQLDTQNKGVIEGDVAVPFMIQSQLDEGTLASIWDLADIRKEGKLTRDEFAVAMHLINAKLAGQEVPATLPLSLIPPSLRENFGPGKQEVLAQPSSATKDLFDLFADDPPPPTTAAPAAAPAAPAAKSLSPAPTGQSKPPALPARTPSQSSAQPFSTSFLGQPPAPPARRQTSQSSTKALSPAATGQSSTPAPSSFATTFASSPPKRGGDLMGDEGGDTSSTPVPDHSAEYGNKQNQLQQTTRGLTDLSNQRAELEGHDQSSKSQLQELEQKLAGAREKHQQELRAVADLRIRVGEQQAKVKQLNTDLITFSSDVSALQSEKTELEQALLHDKEEVRGLQRQMKEVEEEKAGLGMVLERLRKEARQQKGMVTIAKKQLQTAEEKKDGVQKEIRGVEDEIENDKAVIEQHNVSQTTARSAPEGAFSPDRLATASAVPVPGTPQALSPTATGRSNNPFDRFIQSPASASPSADEQGLGNAALFGVGAAATAAAGVVAAGVGGAYETARSALTDEPEQTSQTGTSSVPTPAPEASNEPAPQARDAEDAADKAKANEEAEQDPFGVPTSGPVTAIPAHEDVDPFGAPATPSQGQGGFGTDPFGAPTVTGADAPNGFGADDGFGDSFGAAPAQEARAAATEQSKAPADFDSAFADFDSPAEATEEQATLKEEPFSPPQGGIPAGLPKSHIPQLDDRPEPERSLSTQAVASDSEPSTPYTPGSSVPGAYHAGSQDSFNNSEASTPGLAGVGTAAGVAGLGAAGVGSALTREVQPEEPDTPRAEVSEHYVDAREAADSSDEEEEPEDIEGPKREYGKAKEEAFASEEPGAAQPEVTSVEPVSEPRSGAALAPALAPSLDPFGASASEEQEQKIRRSAPPPPTKAVSPAPVVASAGGPDVGEQFDPFGAPTAVSSSAAFGNVATAQAPRPEQKQPQTASFDEDEFDFSDLPPAQVDQTSSTAGFAPSSAAGQAQTTTQGGGFDDEFASFDEEFNDESGAGGNGNASDLSSGNKSYEMVSPNQPSAAFAGQSQPSAAQQAPAAGGSSGLYDEWGFGSKKGPATESPVAATQGSSQFDDAFGGDFEPAQSTQQYAPPAGPPPPQKDEPALRPPAMPERRPSGAQADDIEDVKKLCAMGFSRDLVIAGLEANGFDFQKTLNVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIG4</accession>
    <name>A0A1E3IIG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029206.1">
        <property type="nucleotide sequence ID" value="XM_019178723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIG4"/>
    <dbReference type="GeneID" id="30195880"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="175" mass="19238" checksum="19B8A128BA9BFA70" modified="2017-01-18" version="1">MTSKFKHPYQEHEIVEALKVVIKQYLVRYDRMVSLQIQVFAGSGAKKGPRSQTRQSSARDDNNWSSRSYSTLSISDRNGKFGLLFDRDIVVQPFKTPSAVLAAAAGELTPRTEMKEGMEITNHARLAVNYFSHLVKDGEAMIENGQKSMKGEKASQPKGTDLPGASAGSTSTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ19</accession>
    <name>A0A1E3IJ19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029254.1">
        <property type="nucleotide sequence ID" value="XM_019178771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ19"/>
    <dbReference type="GeneID" id="30195929"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="19677" checksum="D7DCBDEA29F9895B" modified="2017-01-18" version="1">MKLWRQSNVEWLSAAGVPVHYVKAGGSRHRKERSHIGNVSGEDQNGTTAKDGKDEGDAAGSSVLAITVEDCNKEIKVLQTVLEATEDWIETIEGAAAVCMKGKSLSSSLSFRDIFTTTQEGEFIPPPPPAIRGHRAHQAVLASAYGRFLQIIEEDKDEDGYDAGHLQQPGDSCGYEGKHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJT3</accession>
    <name>A0A1E3IJT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxiredoxin 5, atypical 2-Cys peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029408.1">
        <property type="nucleotide sequence ID" value="XM_019178707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJT3"/>
    <dbReference type="GeneID" id="30195864"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="180" mass="18613" checksum="C0FC9FD0C81C512F" modified="2017-01-18" version="1">MTSVLSSAANTAHSAFASLSSVAQTKAGDTVPNVEIKIDSPDGKLDLSELTGKNVVVTVPGAFSGVCSNQIPSYIAQYDAFKAKGVKDIYVVAVNDIFVVNAWKDKLEEGKASGIKYAADDSAKLAASLGLVLDAAPIFGGPRLKRGALIIEDGKVQHVAVEDSPGDITVSHADSVLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL05</accession>
    <name>A0A1E3IL05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029483.1">
        <property type="nucleotide sequence ID" value="XM_019178576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL05"/>
    <dbReference type="GeneID" id="30195733"/>
    <dbReference type="OrthoDB" id="2575452at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="289" mass="32269" checksum="3DB5EA54B3A34B10" modified="2017-01-18" version="1">MSGNPSPHHAQPYNPQPSPSRPLSFYPGPHSSPCDFPTSTDTTHSGAQSLGMVDTFLGQNSSPTRQSGQGERAEEYIQLGGPEQTREEYYGDGSGQWPEGYRQTYPSSMQYTEDGVQIHSQAQAQLPPPGQGHYNDSDSDPSNPMPAPGQPEQEPEEEFDPMAPVERFDAKGELESKWNALQDEMVPFLQNFTNEALSNTYSSLPAMQTHREADVTLSFDLILQAHYMYHQLNTRMQRELVEGVKAIDEEEMKQEAARKVITDFSNEMKRAAEVLKMFGGSEAFRNATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM13</accession>
    <name>A0A1E3IM13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029552.1">
        <property type="nucleotide sequence ID" value="XM_019178396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM13"/>
    <dbReference type="GeneID" id="30195542"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118493" checksum="DAA8270BA197486C" modified="2017-01-18" version="1">MWLLTVVGKVRGQNNFTFALQQDKTYSIGNSDTCDINVNDKYIRAEEGAISVGPWDVANRHETPSLRWKPKESTKGVQKDKYLLLPSGAGPHDVSTELKKYDRAHETAGQSVDLNASGVVGIYLTDNAWFFVEWKDLTIFYSNQRHPSSECIEIFKQYCIFMTTQMLWDDLPTYLVTDTIRGNHECRLAICGGVHLILPGFFDYVRGRLESNWSPTVDSYCSMDVPIPGDNREDFRPAPAGNVPFPAGIWLPGKDRRKYFRKWNVLFLKESAASKEVNFFKVMGATVREMDVEEKPLQSRATLEKAVIEWLGIVEDTGHKSKALVIYSNKAKPFFDMKDLEGVCAAVGIQKGTAAVATSVATSGGAMEYFHKRESKASAPSNAKTTNNADSGENSARAPAIHVRPSSPDAPTNDKADDEPRDVVPSTFPNDPISSVVNSNIPQRKVYRRGRNATSPNPPSELPVTAGSSEVGKSTAVSAANLTPNARSSRGPSPQPSFVPDSAPLQSEPPQARTSGPALTAAMSSTQLNSVPSLTGIPTRTVTRRRVATGSSGDSAAPAALAARSRPHARSDPAASVASAKRTRHDVEESSEDESDKYVQALYEKKGNSFGATKKARTETEPDVEMAESTEQSTRASRRMTDKERFKAPSELMQVDTATQEESEEEEPDLFKQTLMRTKRQAAGKKVGGNSLGRTESQNLMPPPTQTQARGSRSASPQPPTRSQPGSSQAQDLSSQTQRRQGPMITTQKRAPNTEPPTRDEAFQAALAKNRKEKEKIDQLDRGLSQMTFSQRETGKEVDKPAYEVSDDFENEETTGNFVEIVRVAGLFRKDLGQKKQAVRGDDGKPNFKKFHKKDAPRRIALKMVLNASIIKEPAMSMQSYWPQEEQKKKPTSQNAFDDDDDDDDRPILPQSTGARRLLRETGFGEDDDEDDDMIPSTSRTGTSTQRSRVPDSQPALTAGRASGREKRAASVVSNASEAPAASSRPRGKGATKTAAAGKKKRSILEDSDEDDDEIVWGTSETFGRSAKNKKASIAGSGTATLDDPPPTATAGRRGTQRKRLVVDDDDDEDGFANFKRQKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM25</accession>
    <name>A0A1E3IM25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029319.1">
        <property type="nucleotide sequence ID" value="XM_019178618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM25"/>
    <dbReference type="GeneID" id="30195775"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="50"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="40562" checksum="BF205CA60DDA7823" modified="2017-01-18" version="1">MATFASRPAAPAQDPKLQPWVEKYRPKTIDDVSSQDHTVAVLRKALASTNLPHMLFYGPPGTGKTSTILALARQLFGQVSLAAILPDLFKARVLELNASDERGISVVREKIKTFARETPRHAPGVSSDGKSYPCPPFKLIILDEADSMTQDAQSALRRIMESYSKITRFCLVCNYVTRIIEPLASRCSKFRFKPLEQGSTQARMDMIAKTEGVDTEEGVLELILELAGGDLRKAITYLQTGQRLHAASNPPTPISALSIHEISGVVPTSLIESILQSIGIDPSTGIDPSLLSSSSFTSVRTAVLQITREGWSAYQVLSQLHDALIPLPAIGAVEKSLAGLVMAECDKALCEGGDEELAMMDCLLRVKEIMGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM86</accession>
    <name>A0A1E3IM86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029623.1">
        <property type="nucleotide sequence ID" value="XM_019178467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM86"/>
    <dbReference type="GeneID" id="30195619"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="79" mass="8855" checksum="758A7D13CC3BE1ED" modified="2017-01-18" version="1">MPPTDLPPYDLATHSSSSNDRRTRNSERTSRACTTASNLCCRSRKTKCTGELPMCQTCLFYGQNCEYPAVDKRTTDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA8</accession>
    <name>A0A1E3IMA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029399.1">
        <property type="nucleotide sequence ID" value="XM_019178698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA8"/>
    <dbReference type="GeneID" id="30195855"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="63550" checksum="1B98E0FA2C16F247" modified="2017-01-18" version="1">MPLTTAAPNPGANFIGESLGDSKIHEGNGYRLTEDDYQTARDVAPSRIKGNWLTWMVTFVAGTGFTLFGYDQGVMSGLLTLDSFEQQFPETAGGFEGSTTATLQSLLVAIYEIGCMAGALSNIWVGDRLGRRHTIALGGFIMLIGSILQTAAIDYAMMLVARVITGIGNGLLTSTVPAYQSECSKAYRRGQLVLAEGSLITFGVMVSYWVDLGFFYTTGSISWRFPIAFQLVFIIIMIVCLYAFRLPESPRWLAAKGKFPQALAVLAALDNTSVTDPAVVTVFHGITDAIAAEHVGEFSFKEIFKGGKTQNFRRTMLGVVAQCYQQICGINLITYYLTSVLSGLGLSDEMSRVISGVNGTCYFLTSLIAIAIIERAGRRSLMLWMALAQCATMAVLAGLYNKAQDQNKAAQVVSVLMLFLFNTWFSIGFLGITWLYPAEVTPLRIRAPANALSTASNWIFNFMVVMATGPMFANIGWGTYAFFAAMNGIIMFPGLYFFFPETKRYSLEDLDIIFAKAYVEGLDPVKVSLHPESVPKAGSREAEEILGRNVDSQKDGGNGARQRFDGKEKGEKGRIEHHEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ86</accession>
    <name>A0A1E3IQ86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029869.1">
        <property type="nucleotide sequence ID" value="XM_019178150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ86"/>
    <dbReference type="GeneID" id="30195295"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122065" checksum="46CDD81BC2CB8C9A" modified="2017-01-18" version="1">MEAILDFNQDLDVGLIDQVVTAFYTSTGETQQTAQRVLTQFQENPDSWQRVPAILESSASINTKYIALQILEKLVQVRWKTLPSDQQTGIRNFIVGATVEIASDESRMRREKGYLNKLNLVLVQILKQAWPKDWPQFIPEICQSSQSNLSLCENNMIILRLLSEEVFDFSAEQMTQAKTKALKQTMCAEFGEVFQLCNEVLDKANKPSLVEATLETLLRFLNWIPLGYIFETSIIDILVGRFLEVPDFRNVTLKCLSEIGALNVGPEYNSKFVALFQVVMTSINRMVPPSTDMAGAYASSDDEDQQLIKNLAIFLSNFLHTHLRLIETPENTELLINAHLYLVKISTVDDREVFKICLEYWAKLVTELYEEIQSLPLNDINPLMNLNLGGLGGGLNGAQGMGLNGMPLRKNIYSDILSNLRLVMIEKMVKPEEVLIVENEEGEIVREFMKESDTIVLYKSMREVLVYLTHLDVVDTETIMTDKLSKQIDGSEWSWNNLNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVCASDIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIAQKCRRHFVMQQAGEQEPFIDEILRTLHRITVDLSPLQVHTFYEAVGYMIASQPNKPTQERLIEKLMELPNNAWDNLMQQAASNVDILGNPENVKIMSNILKTNVSACSSIGSFFLPQLGRIWLDMLGLYRTVSGIISDDVANQGEVATKTPKVRALRTIKKEILKLVETYVKKAEDTQGVYDNLIPGLFDAVLGDYNRNVPAARDAEVLNVTATIVSKLGPILSPQIAPILDAIFEPTLTMINQDFAEYPEHRVGFFKLLRAINLTCFQALLEIPPAQFKLIIDSIVWAFKHTMRDIADTGLNIAYEIVNNFAASSPDISNQFYQQYLLSLLGDVFFVLTDADHKSGLKMQGMLLAQLIALVETGQVQAPLFDPAQVNDAGMTNALFLKGYISDLLTNAFPNVQPSSLATFVNLMFENASDHNKFKLTIRDFLISLKEFSGEDSGELYLDEREAEAEKREKEQREAASRIPGMLKPAQIDDDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQK4</accession>
    <name>A0A1E3IQK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029738.1">
        <property type="nucleotide sequence ID" value="XM_019178300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQK4"/>
    <dbReference type="GeneID" id="30195446"/>
    <dbReference type="OrthoDB" id="10420277at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="38000" checksum="A6A2E8300F8D0A41" modified="2017-01-18" version="1">MITALAPLRMMMREVEEVEMDMGMIRKKKKKKKEEKKKKKEGEEAECMRRGLMLNQKNKKKPSKPPRTAQSPALNLTQEEQAHLHKKIKEQAQTITRQRLSTLPPLPNGQPLNPQTRAQLKAPLFHTILKVLEKQQDKGSRAKGIQSIVPTLLIPMPGREGREGKSVVVEYVGREGVWREVKGGKRPDFERYEDMVDGCPLDHIKQGSLVEEKTELSDEARTEKDPSPLVRHKDGISSLSQKAADISHRFLSSLLLSHPQGQLIHLKTRDDVEKAIYKAAKVVLKLYKDKDVGQLNLIPVLVLPMGNGMDIQGKWVSSLGEWEDKPGDVVVSVRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRX6</accession>
    <name>A0A1E3IRX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029990.1">
        <property type="nucleotide sequence ID" value="XM_019177951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRX6"/>
    <dbReference type="GeneID" id="30195087"/>
    <dbReference type="OrthoDB" id="10377554at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="293" mass="31964" checksum="126BF2BA946DB6C3" modified="2017-01-18" version="1">MPDNNQQASENVSSDGQPGSSATTADRASAPRSSAASQQAVITTPSGARVASTASFRVLNDQQLQRAIEADTKRRIAMGLLTTAASSSRPGGYRDESTLYMGHASQGGSMMPPPPPRYQGQSGSQTFGEQDFYSNLLFNDDIGPEDEAYMNLYRARGSDPSDKGKRPALEAPPLAQHPPKQRRITETGTAEDEGESDEVQEIDPATGQPVSEGPKSTRPAFRNLTFSVTVEADWGTSLGPQSEDRTTYRYDISSESRSREMLQDVLRNLSNIKLQDQDALAQELREMESRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRX9</accession>
    <name>A0A1E3IRX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029958.1">
        <property type="nucleotide sequence ID" value="XM_019177919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRX9"/>
    <dbReference type="GeneID" id="30195055"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15037" checksum="90A0E6AA0FEA08FD" modified="2017-01-18" version="1">MPSPPAPQQAPLPQRLAPALEPPIAHPPRRLAPAQLVGSTHQPVDTPPQPVAYPHQPVAYPPAPPRASSTKDRTMYGSPTNIGSEYRKVALHHLSPDLHTEAKNKVSNRADDHRAFSVWPMVLFPLFGLSLGIAVCFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS64</accession>
    <name>A0A1E3IS64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030045.1">
        <property type="nucleotide sequence ID" value="XM_019178006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS64"/>
    <dbReference type="GeneID" id="30195145"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN91419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="33053" checksum="1F937127814A47E2" modified="2017-01-18" version="1">MAPKRHIPTAPEIPDELPDSLPIPPLPEIHDVFLRRQVFTHTSYIAARKKGEDFAKEEFQQDNEKLEFVGDSLLGIIVVCLLQDLYPNLNPGNSTLLKSILVSNQTLAQISRRYGMQDLLITDVSASETLKSGMKTVANIFEAYIAGMFYSYLQHGDVTTDDTRGPKTRGEGITYLEAWLRPLFTPIAEWAVGYITLERKRLKTELAAVDGIMDDQFDDVAVKICASARLNEFFTVKGKGIPEYVYEEAAEKGLWSCTVKARDREGDLHVGQATRGAKKKASQVAAYKILRDIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITX4</accession>
    <name>A0A1E3ITX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030122.1">
        <property type="nucleotide sequence ID" value="XM_019177738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITX4"/>
    <dbReference type="GeneID" id="30194872"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN91988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="172" mass="19113" checksum="51364603613EBD5B" modified="2017-01-18" version="1">MLIYTDVLTGDEMVSDAFPVKEIGLVAYEVDCANIIVKEGDVDIGGNPSAEEVAEALEEGASQVNNVVHSFRLQSTQFDKKSYLTYLKGYMKAVKAHLQTANPERVAAFEKDAQELAKKIVGSFKDYEFYVGESMNPDGMVALLNYREDGVTPYFTFWRDGLKQVSTGRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVM1</accession>
    <name>A0A1E3IVM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030290.1">
        <property type="nucleotide sequence ID" value="XM_019177539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVM1"/>
    <dbReference type="GeneID" id="30194669"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="12">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="812" mass="91103" checksum="8CDEAE43EC5C3014" modified="2017-01-18" version="1" fragment="single">MIWVFKRDGRKEPVAFDKVTARINKLSYGLDPNFVEPAEITQKVVQGIHAGITTVELDNLAAETAAYLTTKHPDYAILAARIAISNLHKETKKVFSAVVHDLYSWVNPKTGKHAPMIAEDVYQTVMDNKEALDSAIIFDRDFAYNYFGFKTLERSYLLRINGKIVERPQHMIMRVAVGIHGANIEKVIETYNLMSERYFTHASPTLFNSGTPHAQMSSCFLVAMRDDSIEGIYDTLKTCAQISKTAGGIGLHIHNIRAKGSYIAGTNGYSNGIVPMLRAYDATARYVDQGGNKRPGAFAIYLEPWHADVFDFLDLRKNHGKEEVRARDLFYALWIPDLFMKRVESDGDWTLMCPAECPGLADVYGDEFEALYTSYEKAGKGKKTIKAQKLWFSIMEAQTETGNPYMCYKDAANSKSNQKHLGVIKSSNLCTEIMEYSAPDEVAVCNLASLALPAFVDLEHRVYDFKKLHEITKVVTKNLDQVITRNYYPVPEARNSNMRHRPVGLGVQGLADAFMALRLPFDSPEARLLNIQIFETIYHAALEASCEMARDQGRYESYEGSPISQGILQYDMWGKEPTELWNWVELKAKIAEHGVRNSLLVAPMPTASTSQILGWNECFEPYTSMLYARRVLSGDFQVVCPWLLRDLINLGLWDENMKQNIIAAGGSIQNIPTIPDDLKRIYRTVWEISQKSVIDLAADRGAFIDQSQSLNIHLSNPSFPQLTSMHFYGWKRGLKTGSYYLRTQPSAQAIQFTVDASTLKAAKEQKNKPTIAASPAPSSAADAIVAPMRQVSIATTASRLPTPAPEEQSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW21</accession>
    <name>A0A1E3IW21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030240.1">
        <property type="nucleotide sequence ID" value="XM_019177856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW21"/>
    <dbReference type="GeneID" id="30194990"/>
    <dbReference type="OrthoDB" id="3153298at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="58961" checksum="002B9E8B3D9E20BD" modified="2017-01-18" version="1">MPAYVPPHLRKKPTPTTPSSQGTSSTSSFSQDNRSPQSQGRSYNQWSQSGSDSSHPGRSHFASSYYTPRGGRSNGNSWNDSPSRPRNPKLYTQNSPAQLHVFGDSFVGPMKLVNADYVQIKTFKGASAKGLNNPKSIKQVSTELLPILNSLLVPPPYAYQSNRGRSAMLVFGNVDLQINYVWQLANKPIETLSSTYSALSGVKDERPSEPRRTSSSDILASATETSSAGPALGPEDFVRAVAGAYTSWLEREIVNSAIGERLVSLSKRREADPAAATGAGSKILIASALPPLIEDHMLPRIPEKYVERLEEDLGKQHRAVESLNAAGRNTWRGGKGDEWIDGMSSLKVSDDPVTRPEVSPGGSEISTVDSPLPTTASAVSTAPTEPSLYAPSPTSPTKTPITSLLEHDPPLCTLPVRVKMTNHYNSVLSAFCAKYPEIFTFIDITPAMKAGSEAPSVHGEVDRVVWACPVDPTNVHPLWEPTLPLWLAELKKLGIDTDSWEMSEDAEETFKAYEIDKRRRTEKDKNKYSESVAPIKLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW23</accession>
    <name>A0A1E3IW23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030447.1">
        <property type="nucleotide sequence ID" value="XM_019177696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW23"/>
    <dbReference type="GeneID" id="30194829"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="304" mass="33147" checksum="31E4E4914BFB9E4A" modified="2017-01-18" version="1">MPTINDLYTADLEDTIRALLKKTGIPGCAITIVKAKEDGGWDEGVWTLGEAKKGVPVTPDTRFPLFSMVKLITVLAVHQVLSKTSYTFGTPLKTIIPEFKSPDKALEEGVTVADMCAHVSGLPAYFDVFQIGTSLEDILESVSKLHPTAPLRTTFQYGNLMYSLLGLIIERISGLSYPDYVKEHFLKPFDLDSAGFENDESTAEGHWIDASGGGKMRGIDNGVVRSPATWPAGGLIMSIKDYAKYLKQLPSHPGYQFASTPNSSHPAFADIFHFPYSSTTPTYGGGLYQMTFRGMIALGRVHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXU5</accession>
    <name>A0A1E3IXU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030497.1">
        <property type="nucleotide sequence ID" value="XM_019177344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXU5"/>
    <dbReference type="GeneID" id="30194467"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31866" checksum="4878BDDC9076FDB2" modified="2017-01-18" version="1">MPPSTSPDHAALLHALTNTTLHALTKRADSVPNTFQTNTIIGACVMFLAILIAWNIPILRDVIAGLKLFTVGLHELFHLSAGLLCGGQVVSICIDPNDGGATHVMGLMRTTPRIPRDPYAMPTYPQMFWSPSALITLSSGYIGSSIIGFLFVFCGFDIVASKACALVIHFGLLVPIMRADHWIAFASIIVCEAVLVGLWFGDHGNALRFYVIFVGMMNLFYVVWDYIDEKLFDKRNTSDCAQFSELLGWPTSSWAILWFIYDVLVFTSAIFAGIIVFRRTNDQMYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J014</accession>
    <name>A0A1E3J014_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase (Ubiquinone) 1 beta subcomplex 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030754.1">
        <property type="nucleotide sequence ID" value="XM_019177173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J014"/>
    <dbReference type="GeneID" id="30194290"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="163" mass="17902" checksum="CBA78A189B727C29" modified="2017-01-18" version="1">MIAPTALRAARTAAPSISTALPAASRFASASSKLSIANETYPLPPGQEVDPQLNGYPQLPNETLQKRQPFGWWDVQERKNFGEVVHESEDVIGMWGPDVHKTSWQSALLQLSGAFGLVGIAAFFLIQTRPERPAVAREYPYNGLEQELGGINVARKEQVDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B6</accession>
    <name>A0A1E3J0B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030858.1">
        <property type="nucleotide sequence ID" value="XM_019177277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B6"/>
    <dbReference type="GeneID" id="30194397"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="152"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="612" mass="69713" checksum="523749407DE06E48" modified="2017-01-18" version="1">MVSPHAKEETPIASRDNSIESLSALPSDEDYDVERKHTDQYPVNTLTSHQPAPDAKDHLPNSGSDPEKPQQRPEAAMGDAILRFLGVRKRLLEDHPDAIATQYSELWDSDKVEEYKKIYIRDDWENIEAFDPSFRWTIKEEKQTRRAVDWKIMLWVCVMFSALNIDRGNLSNATSDNILDDLNISTDDYNLGVTISKVGFLIAELPSQLISKRLGPDVWIPIQIIIFSILSGAQFWLNGRASFLALRFLIAVFQGGFIPDTILYLSYFYPSRRLPIRLAFYWMSSSFVDIFVGFCAVGLLKMRGVLGYAGWRWLFLIEGIFTLLIGIASFFLMPTAPAKTKSWHHPKGYFTDKQVKIIVNSVIRDDPGKASMHNRQPLSIKSIWRCCLDYDLYPLYALGLMFGIPKYPVAQYLSLSLRQLGFNVIETNLLTIPSTVCGLLTQLGITVLSELVNNRSFVASAEDLWLLPCFIALVTLAEPVKPWSYFAVATVLLSYPYTHAIQVAWCSRNSGSVEMRTVSASLYNMFVQVSAMIGANVYQAKDKPRYYKANKVLIGIIVFNCVVLYPGTYFYYKWRNGQKAKVWDTMSEESRKEYLATTEDKGNKRLDFRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1P3</accession>
    <name>A0A1E3J1P3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031027.1">
        <property type="nucleotide sequence ID" value="XM_019176995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1P3"/>
    <dbReference type="GeneID" id="30194105"/>
    <dbReference type="OrthoDB" id="2587819at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="185" mass="20800" checksum="D8080663D87BB55D" modified="2017-01-18" version="1">MLNPKTFNVDVNGVYASLQGLAFPLSLAARAIESETLPSHTDLTADQISQLKVTKWSPEDISEAIQRQSKFVGNMHRIGWLDPGRWLDHGTMELSLGIVLYHAWLDLAHSTSLKYFLVPRLDIDLAWHSHQLHGTGYKTDTERLLGQFLNHDDAAAEDTLGNGLKKTGELWKERFGYDYQPPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J210</accession>
    <name>A0A1E3J210_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031141.1">
        <property type="nucleotide sequence ID" value="XM_019177109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J210"/>
    <dbReference type="GeneID" id="30194223"/>
    <dbReference type="OrthoDB" id="3364141at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="397" mass="44151" checksum="BA5DA9C4FFED0D14" modified="2017-01-18" version="1">MPPLSTPQAAHPASRKRRASSPHAADKRRRPNLANGFSSLSLHTAAQSTPPPIDDTDDDGLGPSNYPRSNDLKVEVLPESSATQETYAPTPHHRHARPHHWSHSSYGRPPPSSSSNSPPSSSDETYDSEATTTRFSRPRRYAGAAQQADEIVQPDANDPVAGYELGIEDVTGVPPPLRGRRPREDDSAEGPIEKRRRRDDMDIDMDAEPEPHLGEPNSIKDRMRKRKTVWHEPEKDRIVITSLSDSDSRSSRSPSPEVELAQGHLSQPGEHGFTLSPSLLTHLMRARRDYDFQVPLSELLRNNERGLTVYRPLGISPGKWKDDIVKTWEEAQADADAGRFEEIDEDEGRSFTQFSNLSEGMDVEPEVAQPWANPWIGQGEATSVDSVDQDMAMDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2C0</accession>
    <name>A0A1E3J2C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031094.1">
        <property type="nucleotide sequence ID" value="XM_019177062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2C0"/>
    <dbReference type="GeneID" id="30194175"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="143" mass="16082" checksum="2AF5385A173FAC2B" modified="2017-01-18" version="1">MSDDGQMEFEGGDYQEYDPDTMIHEDHAEGEEEEANGDADENMIVESGVPEGDRPRTGKAAKANEVRVTTPYMTKYERARVLGTRALQISMNAPVLVPVEGETDPLEIALKELAAKKIPLVIRRYLPDNSFEDWKVEELIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2X4</accession>
    <name>A0A1E3J2X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031179.1">
        <property type="nucleotide sequence ID" value="XM_019176704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193800"/>
    <dbReference type="OrthoDB" id="2569225at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1370"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1634" mass="178149" checksum="E89BC140AAF4DBA6" modified="2017-01-18" version="1">MLFYRQVMMPHSRQSLDVTPSTPSGSKCLPSSALVCTLLPVSSTNTRHQKRPRLPASTHPRYIIDRSRYGITIGPTSPEFLGGGDDLDDIEEAEGLVWDLALAPESDQDEEGRGEGDNREAREPTRIGLSHQKTGETRRNSEARSSTGRTKSALEAPQRLPLSVRTSTNALPPKPKHMLAARKTILPQKTPLTRPLRSARKVAVATDLFDGDETDHAEDSDPDDLRLSPPRPQSPIAKQRPLSSPESAGPSKVPRTYTVDFEHRKRMADTALGPRTTKRQRRSDGQYRRSPQAPTTLVSSGDTTATRQKKRKAARKQVAAITVIDLTWDTDSDEEEGHEMGSSPEMSDGEEETSFPRQRSKTSREREDAILSQTNHRPLETIRAIPARMIAQNIDASESGSPMNLTDDTRDGSDAEVPVGDDNVNEKVQEDPLHDMIAPELFISEAPQPASPTPALRPPLLDVPSWELPTIEGVAQDLSSSQFHLRRFSSIFSRRIARRSPSSTSEYLPSYNCRPFLRKNMRIRLQGTSAFLDPDDAESIEYIARLNQYRKLEGTRRKEDNALGIDMKERFRVVDEDLVARGADFNLLKQGVVLNMTFEGVFPVGRAPSKCPYQAQIIVRLEETVLHAVTVPIVQYKIHPQTTLSIPLSETFIKNRQPDYRTSMKLQILLFSIGRVQELYTSSDIDIVASDGHLAQFGPSINLRPTSLGDQAPPILLCLKTDYNFLPSPRFYPVSVSLSKSSKDVEVTYIVKKSNAGQSSVVVVSGFTCPLCSDLDGAGHTGSRQALFLHLSGHRKEAKLDEKRSTEKITRSGRLLKLTVFLKSRAKTSLVFANKYIKFHHLLPTLAGFSHPSVTSSPTEADGPMLSSPRQHLTLTKISSATHPPPDKLLEKPSLTSEGGTVEGALLAPAPDDDGRSSAVNEMSGGVEGNDVEDTPQKPAPHAEGGSPAVDELSQTEAMDVEESAPVAQATSSKSGEMEGNDVEDIPQEPAPHADGASGELSRMEAMDVEESVPVVQAMGAKTGEIKRNNDEDPSQGPASHADGGPSVVGELPRVEVMGVEDITPVAQATRPKDLAENMPIVPTGVYADIKEITVSASSPPRIQPEISAVVGSSDLEADKDQNLVDSGVSNIQSSPPIQAKDDKPAAPVAPSCSSVAGKEPDTQVSRGSTTTPTSLSHHPQRLSQGVRSPSLEHPIPVLQSNADISAGASNVEEGSEGIVPEGHSSVLAKASEPFQRAEVVPDLSEPEQENDETEGSSTKVVEAVSQEQTSITSPLARTEPQHTAIVSNSADTDTEDAPVFVPVIKAPRKTQLPSREIESVKRPMVRLTLPAQKSNLSELMPEQSSASDSRSSSIVAIEQEDIAMDTEVDTAASDTVDDAATPVPETPTTHPAQPKLRGMSRTPQASTSLSQSSTPPAEDVSKVAAIMQGSVLGENEKSNDPNTTPVEAVSPSRVPDNGMQQEAKSDSDPQNQLRPGLRDLAVLRYTPRFTESGFAGPYMGQRVNEWTEWSHAVVPGTLFDFMHELDKLWDCGGIRHVVKHQEASIWTRNHLSEKRRFLACCWNRWTYEKGPIPGINKAGHLKLFLDKYGTIMTRAGIDFELKDYLHIHFQMKHISLADYVGACQYYKGIRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3B6</accession>
    <name>A0A1E3J3B6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031324.1">
        <property type="nucleotide sequence ID" value="XM_019176849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3B6"/>
    <dbReference type="GeneID" id="30193953"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="68"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="491" mass="52948" checksum="0E8D039AB7F225D6" modified="2017-01-18" version="1">MFSSRDTKADDEKHNNLGVNDQKDVERQQDDITRVVSASSQINTIDGETVVDGVWGTLEEDAPNYRGLGWIRASVLLVKVQIGLGVLSIPAALDALGLVPAILIILAVCLVITWADYIVGVFKLHHPEVYTLADVGQIMFGPIGREIFGAFYWIQLVAVAGAGLLACSVAFNAMSEHGTCTIVFVVVAAVINILISSIQTLDRISWIGWIGVGGIISSIVTLTVAVAVQDRPSAAPQTGPWDKEVMIFNNPGFILGISTLSNIIFSFAGTPNFFNVIAEMKNPRDYNKAMGVCQTFVLSCYLILGCTIYHFCGEYIASPALGSAGPLMKKVCYGLALPGLIVSCVLNTHLPAKYVFVRVMRNSRHLSANTITHRVVWVSCVIGSCAISFVIAEGIPVFSDLISLIGALIATPNSIIFEGMMFIYDLHTNPDKYPNRNKWWHKGLEVMNWVVMIGFGLFATVAGTYAAAVTIRADVSAGSTTQPFSCADNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4D1</accession>
    <name>A0A1E3J4D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031395.1">
        <property type="nucleotide sequence ID" value="XM_019176467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4D1"/>
    <dbReference type="GeneID" id="30193561"/>
    <dbReference type="OrthoDB" id="2572490at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="59234" checksum="07F80D8DBD34E842" modified="2017-01-18" version="1">MDVSIESPSTNAPGSVDGFDEDNQEDYLDVDIPELNFPPFPKLPSALTVVSFDQFEHKGVWTKAGLVNSEAGPSQPHDALGVPLVAMERPYTGINHTFEEREAHKKEKRKAATERKRDFPITLPNGPKTKSQSPRLDPEDCWKIGDPNSDWVEPSVTSTVKIDVSIPPFTRLINATREFILSRDAVIQSRKNRHLFGILRDQLRIRSLFLGRHWPGSGPNAALYPLRKRRYVDDNAPTLLPTPKGVRVDEACVLLRDPERSVRRLLTLARMKLDSPWNEEPVLDFLEIAAAYFSYIAHYNVFPEANLHNSFKKVASIARSASKKWKEATQLEGIVTKQDGWNRACWAVWGGEFSGPEEMGPEKPAEVEGQVAQEEPQEEDDEDAVTWTVEPIVDKRPSAPTLNEVLPIVKDLLSPRSHSNIRLLRSIPYASRIIVAVLPPLPAGSDAPRFSTQLHRLVTIKSPAASNQEEDKEPDEIVVWVEGDGLMVNGGNQLVGMVLQGRWGLLGEEEDQEGSWWAFKARHCVLPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4H3</accession>
    <name>A0A1E3J4H3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031445.1">
        <property type="nucleotide sequence ID" value="XM_019176517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4H3"/>
    <dbReference type="GeneID" id="30193611"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="144"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39337" checksum="51347DE1157413A0" modified="2017-01-18" version="1">MSSFILACTVFLEPPVVERLHKAFAKVHYHPDGVLPKEALQEADILFTEMVGVPAQITDLKAEIPNLKLIQLVCAGSEKALACPAVKNYVAQSDRSITLANASGIHVLSIPNYVVASILGAYHQLSRQIIFGAVNKRWATRAEIEITDKPYYARSPRGRTVGMLGYGALGRESARLLSCLGMEIIAANTSGSATQQTGYIIDGTGDADGSIPETYYSTKDRTSFEAFLKRCDVLVSSLPNTSATQYIIGPKELGKPPSKERFACQHWSGQPRQVWSSEDLLAELNKPEGEGLFAAHVDVTDPEPLPEGHPLWSHRKATITPHLTGDTEGEYDIAVDILIANVKNLAVGERLYNAVDFVKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4L5</accession>
    <name>A0A1E3J4L5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031473.1">
        <property type="nucleotide sequence ID" value="XM_019176545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4L5"/>
    <dbReference type="GeneID" id="30193639"/>
    <dbReference type="OrthoDB" id="2576031at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="409" mass="43167" checksum="DD4AF205D91C819D" modified="2017-01-18" version="1">MDDDFEDLLRDETYEEQVDQSVLKRDTPKPSAVTQAAPSSNEIRLGRRVLELEKERDSLATELQALKSRLPTHANPTVPIQHPSASSAPETDQPVDIPPPLLPLMNTLRTHIAELTRDNQALRQTFLGQAIPRRGPISQVATPITAQTATLPNALAPPVAAGILQEDEEMDALPEAGTSENLSPHSALAPSRESAAGLDLERVLETVKTLVQENEELGEMVLEAGRGSGSDWQTSLEESKAVIESLDSDLSHHLSVVQATRAELETYQNHFGPLPFNIAPNATAHPNAIAPSGTPTASRGLPSFVGRPTPTGPSAAQQGRGPRPFVPKQPGQGQGQGIGRGGKPGFQPAAGVRRPFSNGPGNGSGFSPGNAPASGQAGGDGPTTGHVRGGSAGQGQSLRQDERGFKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4T4</accession>
    <name>A0A1E3J4T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031534.1">
        <property type="nucleotide sequence ID" value="XM_019176606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4T4"/>
    <dbReference type="GeneID" id="30193701"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="22530" checksum="A5B058A585A3EEDB" modified="2017-01-18" version="1">MSKNAQYVYVWAVYDRQARKQPGEGNGFDERYPEIVQVLRLSHVCRQMRPLNKTQFKKHSPNVEHRSQKHVGIEIQWSTIWRNVLRTFEEYVAPEEQEDFSFDDPVHRLRIIGEEESQMFGDLCVETRDEASLTWWDDDQEKILEAAHAPVFAKLGMCPLSEEIGVARVWTLFWPMLELVQAPLEAYFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5E9</accession>
    <name>A0A1E3J5E9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031151.1">
        <property type="nucleotide sequence ID" value="XM_019176676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193771"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1705"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="739"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1728"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1738" mass="191601" checksum="3FFC7B150DF97869" modified="2017-01-18" version="1">MAFIGSGEFEDKITHLQKQLSLKDHELNSIKNEQLKRQEELAEAKKAMETAESQLHEEADRALKAKNQLVCNEMEISQLKLNLSNLETSLGTTSEKLKEEKEKDRVQDALDDALSRGLDRAADQISSQQLLIKQLEDNVRNSEQEAERLRAQGSSGGSNGSDEPLNYRERIRLMSLQNENAELKTQLENMSSAIPSTSQSSIPSSPVKKKSRRSLSLPVSDIRALEGQVGSLKTQLANTKRGYDQAVNEKLALEHATKKNVARLKEDLEEARREVAYYRASNGGVDVKQVEELKTAAQRVREEKEDLARKLSEKEGEVKRQLGETARPEGEAHLLESLRAELDDERQARQKLEAANADQPASETNSSLEKVSALEAELAKVKAATNTTSRSGDPELRQVRRDLQKALRDRDYLDSLVKENDELLAEKDEEISRMRAAIPIPGSPVLGAQGDSSRVAELEEEKAGLLIDLEKQVEYHAQEIAAIETKLSVTMSELDHVKAAETEARQKFEEGQTKITELQDGRQEVSIALEQARAHLASRETVAKQLTQQLTETHSALGEKQAALASAEQEAQDILDRLSKARTALAEKQNDFDQAQRQRDDLQTVLDSRSYDDAEYEALRVSFQQAQDALEEVTHGLEKAESENRELNDRVAESQDEIASIQNQLQETVAHLESSKADSHQTVSELEQASRKNHELEIRIWELDAKLRETSQAATLSTAKVDESNIRHEASPAAAEAGATELNQRVKELQSSLQSASKTSPQNSVNLADTKEIVEKLGRLRAERDDLRHNLSFVQNECHFAVRAANSERDEVVKEVQRHKENLRKSKATCKKLEEEIGRLRIAEQDKQTELDGASSTFANDKKQLDEHIVNLENSLAAAQADAAALNSRVAELKSNLQTREDVLKLTEAKAESLQTELTNVLHHVAQSRKLSDRPESRASSTVASEDGDLPDDLASAVPAESRRLSHQRSRSGVLPNVLMERTLQDKIERRDVRITVLTNDLKKAKSNLALLESAQEETIAENAELEEECGTLQKQLDTEAQSSAEDARGLVLALATYRQQLHGAELRWSVAQDVLAKAQEAAQVLRSTAAADRKASFEQEARITALEATHAITSTALATARSEHESARAELESFREANEHLQTRIAESEQAGVVATDSADRLAILGSRLSEKEERLRDLSTRNDGLTAKLELMLKTEKEAVSQVAEKEEEISALTGRIEELSLGVADAQSAAASIGSEKDRLLEELAEAEMASSESLANIETQKSIAQDRASKAEEELAKVNQQLDQRNKELALAIATSETLSAELQAEKSRSAENTVNIDQQQSTVDQLRAEISSALEASKTVEAERDALRTQMCELQAQVSEDEGTAQAAARAEERLAVETESARRNIKELTELLEKAVAEKEELSQQSKSVDQIREAAQKELAESRSEITRLSAERQVSEDKLSNVRIRSDEALQRAEALEASLASLKDENEKLKGDLAQAMTVSSTPVVDEQLVIDLRERVDDLEVALTQKNKEVDEADDQTREAFKAKAKLERKIGKLTRQLEQAQTDVNTAMNKLLSSRPIAPSPAKRASAPVPVPSRTSMPPAPTTAQAAPAPVSRTPRAILPNIFSPPAAPGSGHKRSRENDDAEAIRPVEAIMLPASSNIISPRKALGSKSSFTPQRGGAFAPLSARLGVNGNVTAEKPVIGEMKKSVDMGRNIFAKPSPVTTEPAKRSAFPLPPSRTPFNTTRRNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6F6</accession>
    <name>A0A1E3J6F6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031668.1">
        <property type="nucleotide sequence ID" value="XM_019176258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6F6"/>
    <dbReference type="GeneID" id="30193349"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="724" mass="78958" checksum="1EFCBADD720BC5BB" modified="2017-01-18" version="1">MASSTSLLSTSPSSSDEPQFIGRSSSSSKATAAPRPIPHQTCCPTQVVQEAHNGVIQPSRISSMKSLAHKYNFNDSGPSSGTVNGRSQVRHTTPGSESEDPPLRARTHPRQKKASQAIARTRPATQNTTLLLPGLLPDLISSPAPVPDWLGRTAVLLKLKDCPVCRTRWKGKESGMFRWRHISTCRPPLYRSPNAPPNLQQMIHDALSVRSAPNTLLELHAGSIAQAEGALAAQGSSNGLASVTSVKRSDLRGEAWDDEVIDRIRGWIGHSSPPPLFNQATSAYNIDPPPPSNSHRRTSQNDADRVPYLATQPMGRSDLAQDYLKQEPSPPVIGSTSSEEGDSVPLSDDSEILVPASDSDSDEELPLEVKKPFQEAAFAGLGKDVEHDVQEPPDVAIVDVERKIKRTLDSPIGGLHAKLSRLSITPEAHLWTQHEVSPSSTLKCAPVSPVLERSTTPTAPYTRSFVDVDGWGAFAFENDDPVAILSWEPKASEPDSASDLDILGYQAENSGTQSHRASGVMITDSDGHLPVGDGGEDAELLANNNEAMSLISIDDHMPAYELWDVKDLQARYGYRPVKNHTVLVRLAIECWKALAADPESPSSPPGPLLDSATWSVAVQSLPGGQMGDIAETEDPQATEMSCQKVKKPEVEEDLDQVFYGVIKEDFDLYLRVLRYEPLSLDELISKSLRAGITKKGWKAHLKRYLDLQSITYFTEDPTKQRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J955</accession>
    <name>A0A1E3J955_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase phi subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031974.1">
        <property type="nucleotide sequence ID" value="XM_019176061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J955"/>
    <dbReference type="GeneID" id="30193148"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="760"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135912" checksum="665B718D6CABA9ED" modified="2017-01-18" version="1">MASNVLPLFWPLANSAKETRLDASASLVNSLQSFQQSYAGPSKAANEEAQDDEEQEDQDSQSDDGDESGMEVDASDDEGEDGGMNVQAVKLDRQMSRNNAEDVVYSVKRLVRGLGSSRESSRLGFAVALTELMSRIPTITAPQVFSLVIRNSQYSKNMKGSDERDMMFARLFGMTAIVQSGALFTAGAKAEDFEGVVQQLVALGNAKAWMRESSWWTVVQMTQALAGSQVAWKEDALKSVLASAFEEKGWTQEKVALVLILEQCDLDIEWKQHLAPTFKYTPLLDSHNLVTLGRVLKETTGDEEDGVSASTTGSWKPQLHFVWNIILERYFPNSEPSTSEIDAPFQDFFRVVVDESLFSNTASPQRRFWGFQVFERAFPILPESQMPLIFTPNFMRCWVNNLSSPDRYLHKAAQQIAKRVQEVIKGNPKVGFTLLSQLVGKHGRTDFDKVTKTKTVESIMGNLNEEGARDFVDYLKDIITGTSQDNLDAARLDERRLWALEQIQALCRNGNVPKKDAWIAPLLDFMVVHGFFIIRNVNKKSSISAVHTVPRPPLSEVTAAACRAKFFACIVELTIAAVPRRSSEDTTVPRQQGCDASGKLWIRRVVDTIAVLEKDKKHVEVLTDADDEIREIRKEAFKNLALLANATKDQQEVAKAFEILISFFILQTYDEVSDSIENIEEINTAVQTYLGKSHEEVAAVDILLDVLVGLLDKGSSDLRNLANLVFGMVSSELTKSSLEHLAAQLEQSAAEAAADGHSDEEAEDDEGSSDEAEDNESESDEDDAQVDDEEMGDVDPEFRKRVAEALQVSGMGGDGEEDGKSEADSEDDEVWDDEQMMKVDEQLAKVFKERATASSKNDKKQNLTESIHFKNRVLDFYDTYAKRQSTNPLILQVVLTLLKLVREGGVSEAEVANKAAGILRGKFNKPKDIPSTADISTATTILNDIHAMAQKAHSAEFSNLCSLASLFVARVVDASTSGSKSSPVVDAYRSTLKDFVTRKASLVHPPFILDFIKRFPFQGFALSPDLISFVAPGVAVNSFRQVQVYSALQTLAQHLPVISKTVPASDVATFVNDASTRVFTTLEAASTADSDSKESLNAQRLKEVVKFALQLARNSKIVGVQWDVKRVEAVGSQLKSGDRTKEMKGVHNMWGQLEGILGNKKAEKSKSKLEHSEGEEMDVDSERKVAETSNGKAKKAKRSSDAAAEDDKPKKRKAEEGAEKKKKSKSKASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC05</accession>
    <name>A0A1E3JC05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032251.1">
        <property type="nucleotide sequence ID" value="XM_019175761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC05"/>
    <dbReference type="GeneID" id="30192846"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19823" checksum="747AAE398AA27283" modified="2017-01-18" version="1">MSQARHFFKTKAARDAVRLLAWVPVGVFFTRHVYSLATVSGGSMQPTFNPELSSKPLDKDVVLLERWSVAMHRYQRGDVVTLWSPQNPELLTTKRIVAPLPPLPPTPVRIPPGHCWVEGDSKYQTRDSNTYGPIPLGLVTARVSHILWPWIRAGDVLSSKGKSEGRVKRLGEEYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC45</accession>
    <name>A0A1E3JC45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032305.1">
        <property type="nucleotide sequence ID" value="XM_019175815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC45"/>
    <dbReference type="GeneID" id="30192901"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN98443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="424" mass="45953" checksum="795C102111CD5272" modified="2017-01-18" version="1">MVRESLAGPSFVFHHMLTAPVYSKYYDLLGVSPEAGEADIKKAYRKNALKHHPDKGGDPEHFKELTHAYEVLSDSQQRSIYDQLGEAGLKEGGGMGGGVDPQDLFSQLFGGGGGFFGGGGGGRERGPRRGRDLVHRITVSLEDLYKGKVQKLALSKSVICKGCDGRGGKAGAVQTCTGCQGRGVKVMLRQLGPMMQQIQQPCGECEGTGEMMNPKDKCKTCNGKKTNQERKVLEVNIDKGMKGGQQIKFAGESDQQPGQVAGDVIIVIEEKPHPRFERKGDDLFYNANIDLLTALAGGDFAIEHLDDRALHVTIVPGEVIKPDALKIISGQGMPSYRHHDLGDLYVRLTVDFPTTIPTDVMPLLEKALPPRKALPKFGKKVHVDEVVFSEPNEKHARTAAAHDGDEEMEDDEEGGGPGVQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCG5</accession>
    <name>A0A1E3JCG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03793</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032409.1">
        <property type="nucleotide sequence ID" value="XM_019175919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCG5"/>
    <dbReference type="GeneID" id="30193006"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130243" description="Tafazzin family protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN98547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="283" mass="31651" checksum="085577E5C17B1CE7" modified="2017-01-18" version="1">MALRNLASAVTLSTLAFASKTFLRLTTKEYKMWSLLPLNTYFPFTTPSRTCRNNRWTLGASDIMFTKPTHAKFFNLGQVIETHRGGGIFQEAVDRAVQLLQDGSWIHIFPEGKVNQQLTNPAGGLLRFKWGIGRIIMDSQVMPEIIPIWISGFDQIMNETRGSPRIIPRPGAKISITVGQSLTAEIQPLVDQWRQMAHQEAGTLGIGGQWSQDADHTGPAGDQQREIRGKGDLIDGKEEEVRIKIVEALQEGLRKLGQEVESAEGRFKHGLWSQSTAQTSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEH9</accession>
    <name>A0A1E3JEH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032368.1">
        <property type="nucleotide sequence ID" value="XM_019175878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEH9"/>
    <dbReference type="GeneID" id="30192965"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="327" mass="37358" checksum="E991BE119DFFF030" modified="2017-01-18" version="1">MSDLKAYLAANYMSGPKADAILARSSEPNLKKKKKKKPKNEDYIGGSGTKGEEPSAGGILLKDEDESWIGQNEEDEDVDGPMVGKELATFKKSKNSWATVADKSALPLPEAGPSHSAEDEQVQEEPEAPPVQMTKRRGGLRTYAQLKEDTEREKAAQRSASPVGDDDRPDPTATVYRDASGRVIDMQQLKEEEKRAEEEERRKEAEKKEWTKGLQQRREREERARLEREMADADVGRTKDDVRMNNDMKDEERWNDPAAAFLTKRKKKGPRRPKYQGPWTPNRFGIPPGFRWDGVDRSNGFEKKFFQAQNTRARNEYEHNQWSVEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF16</accession>
    <name>A0A1E3JF16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032511.1">
        <property type="nucleotide sequence ID" value="XM_019175408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF16"/>
    <dbReference type="GeneID" id="30192489"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="617" mass="68262" checksum="CD43BE93674469FC" modified="2017-01-18" version="1">MAIRKETGIWSYFITVLQVIKQSGSTAIHPGINRISLKLQRRTSSGAPSPLAAVPQPIGDSPTVVSPLAPPTDLFDSTGMPHEHVWRPYFALYFKYMSQHFPNCSYQRMIERFETGTMSQFLACCICSLAARFDPSAQDPTSAAAPFIAKAQELVTPLLHLPTHDVFTGLLYLAWSNYGQNSESGLWQYSGMAMRMAIDLGAHEVSELYESVAHRARIKLLFWSTFVTDRVVAFATGRPATIPEDIIEIPLPVDEDFFPDPSRNFPDSAHEPVEPVPYVQLIQLMVIVGRISNVLNGRRGRALTLVSSAEPLPELVQDLQVRLITFYSNLPTSLKWSADNFKHQHARGHSGTFLALHLWANAVLALIYHPELLKSPSGVETPLNKSLSRNAQLSLASSRQIVECMVFADLVVSASYISSPYLTQPLFVAGMAFIHEMRALNATAEPGKPVDPSRDGSLHPDSAAAPNPTDILMLSRAKQNFSTILHAVYRLEEYWAGAHYVATLLEKRSGFPRPSSKMARRTFISLPDKGLLKRFTTDPQHPQSVGPPTETSLRDSIARTKRSASANSFGLTPLWLSDFMSGYTVENMSSTPADNVDLERLLGKDEMGQLGQKDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFD5</accession>
    <name>A0A1E3JFD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032621.1">
        <property type="nucleotide sequence ID" value="XM_019175518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFD5"/>
    <dbReference type="GeneID" id="30192601"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="718"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="598"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="754" mass="85146" checksum="879CBAB8D3165B6E" modified="2017-01-18" version="1">MSAAGKEDAPRVPHAPSLHQTRLSAPSIAIDGRNFVDAHGRVLHLRGANVSGSAKVPIAPAPKIHDHAQASYVGRPFPLEDADEHWQRLKSWGLTFVRITVTWDAIEHKGRGIYDEEYLAYLRALLKSMEPYGLIAYIAIHQDVWSRYSGGSGAPGWTLESAGFDLFNDGEALALSGAAFIDGIRGGRLSGERGLWPTGYQKLACATMNTLFWGGETFTPSFKVPTQIDGKWVSRNIQAHLQDAFLDATARLVSAVGDLDSVMGFELLNEPHPGFIGLSTIHEWDYNTDLHLGQFPSPLQSFSMGAGHPTPKVPIYVRTFPFPTKISKYITANPEGASAWSKKECVWEKEGVWRWSEVKKEATPLQEDYFSKDRAGKKIDFYQDFYFPFIHRWEAVVSKNTQRTRGLKARMVEPLPNEFCPEWAEESRPQSMVYAPHWYDLNMLFKKQAGFMSVNVQGLARGMFLPRALYFGLAAIKDNYALQIKGIVLAARLKLGPVPIIFGECGVPMDLNEEEAFRTGDWKWQERSMDALISALEGALLGFNLWTYNPSNRDDIGDDWNAENFSWFSQDNRSKLLKKDEDVTDVDAGARLLNVIVRPYPIATAGSPTSLSYDPFHKAFFYRWRSPIRTSSSAPDLSEYTELFLPRRVFTQSNLKWAVTAGGKVVFDWENERAYVWFEDSAEVAFNAKEQMKTRRIDIWVPEAAMKDVGEVYTTKKFAILVIILAFGALMAYIAQQHEWRKDDVIFGRVQEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFG6</accession>
    <name>A0A1E3JFG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome production factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032707.1">
        <property type="nucleotide sequence ID" value="XM_019175604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFG6"/>
    <dbReference type="GeneID" id="30192687"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="164"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="48685" checksum="B1EC5FDB21FD59B7" modified="2017-01-18" version="1">MPKENKIKNAFKRADVHKKAKREKEQSKLQRRLEIKKAEKDKVNGAALKAERLAKNIPITLDNTRVFDSSSYLTANPATLRELERKAEEASRIANGQGSTGDQDNDSDSGNESMPEAGPSRHRHPEQDQAEGEQGGQHDGDDDADTKSADATNTNDPSAPLPPPRILITTSSSPCKYTYQFCDDLKNVFPGGEFFKRPKGRGYEIGRVARWAGKRGYGALIVVNEDHKSPNAITLINLPAGPTAYFKLTSVIPTANLIGHARPTPHSPELILNNFTTLLGNSVGRVFGSLFPPQPQFRGRQVVTLHNQRDFLFFRRHRYMFSSATSAKLQEIGPRFTLKLRWLRNGLPAVTAPDGRAPTGGDHEADLDSDSDGEDIDQATINKKEQDDEDEAMKEIGQPSAKASQQKGIKVPALDEEQEYEWKWKPKMEVSRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFK7</accession>
    <name>A0A1E3JFK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent zinc metalloprotease FtsH 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032684.1">
        <property type="nucleotide sequence ID" value="XM_019175581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFK7"/>
    <dbReference type="GeneID" id="30192664"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="37953" checksum="C62072A3A42AD0C8" modified="2017-01-18" version="1">MALRPLQARVLFSQGLLVPRCIPHPPPSALKLPSRSLHFSPTPFAIFGSKKSNEPSSVSPEVIANETDHPISAFQSQIAELEIAAQSNKENADAQLALVRALLEGGEYVGLASYYDAVALAEDGSASHALLRSEEAWGIYMEALARSSRMAEVVSKVRRRDRLLATIGAKSAPTSKFSPSPVSPLSSSTSPATASPPSTSQPSPSSVQSTASSLTSSLLGHSPSTSNTSSPSSSGTGTPLNPIYVQMAPPTPQMNAWRALRWVGGFLLWGFIILTVMSMVMENTGLLKAGPGPVEFEPEEGKIVKFSDVHGVEEAKIELSEIVDFLRDPERYDKLGGRLSKGVLLTGPPGTGKSLAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIH2</accession>
    <name>A0A1E3JIH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032873.1">
        <property type="nucleotide sequence ID" value="XM_019175141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIH2"/>
    <dbReference type="GeneID" id="30192219"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="455" mass="49014" checksum="1FD05F06363FBDD4" modified="2017-01-18" version="1">MVLDKGLLTALAQANAGEWIMVLSLVFGGCCSNVWALEGVLRDHPNSGTFLTFAQFTFVAIQNFSSQLRIVRTRSGWRIPQLKNRKVPLKRWSVQVVLFFLVSLMNNYAFGLKIPVTVHIIFRSGGLCVSMMTGYLVGKRRYSAGQVFAGILITAGIILATLSKPKPPPIMRIQDDGFSTSSSAPIPKVDDTTGRSWISPDHEYFLGIAILAGALVLSALLGLYQEQTYKVYGRQWKEALFYGHFLSIPLFSPFYSELVSTYRNYASSAPMTLISLPLPSQSHFTSLTSSPAPPTSSPTLNKLISWQDLLIPSALFALALNLFTQGLCVRGVNRLTTQVNAVTVNLILTVRKAVSLGISVWYYGSGATSGLIIGGGMVLLGTILYSVAPSPKGLPSVSVQDKAKSSSQPTPIELEPEAVELDDLGPAASTGTDVGADPLASAGMRHRPGPLEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIU6</accession>
    <name>A0A1E3JIU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03105</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032970.1">
        <property type="nucleotide sequence ID" value="XM_019175238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIU6"/>
    <dbReference type="GeneID" id="30192318"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="376"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="514"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="590" mass="65365" checksum="1B0A5C5706FB90B8" modified="2017-01-18" version="1">MSYKVSANAPLSISSSSSVSDDDDDRVSDWASSFGEAQQTKSLFDDSLLPNPPLALWHDLEKHGFDLKDAVEKLNLDMFGRIRLINLIRNAGLSKEQIYALKSDDTVFQDDNLLIPVIPDDPYLQYDFDDSWSDDEDESSAAPAPTTGPSSSATDNKGPEDDRSTALEKELEKARRDLAAMQLLVTKTLGAEDDDEKTELKDEKADGKGKGKAAVRDDDSHYFQSYEENGESFSYRISIHEIMLKDTVRTVSYARFLLSNPQIFKGATVMDVGCGTGILSMLAARGGAKHVYAIEASNLAVKARENIKKNGFADVITVIQGKVEDIQLPVKEVDVIVSEWMGYMLLYESMLDSVLVARDRFLSPTGLMAPSQTRLAISAITGERVFRERVHFWSSVYGFDLTTMGGISFDEGLIEVVDAEEIVTTESIVRDINSHDATIKSLDFHSPFTLKATSDKTETVRAFLTHFDTFFSPRSGADSHYPTSHPVSIGQFGDDEYLKPVEPVVPSSAEAGVTVSFTTGPRGKYTHWKQVAFLLRDPIQLAQGEEITGQFRCKKSSTNSRELDVEIYWKKGVEGQTGDGEYTCQAFKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY5</accession>
    <name>A0A1E3JIY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033036.1">
        <property type="nucleotide sequence ID" value="XM_019175303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY5"/>
    <dbReference type="GeneID" id="30192384"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="654" mass="74132" checksum="83B4E2E53F50E039" modified="2017-01-18" version="1">MLKVTSPTRYTLPRPLRLSPVPRCARRFTSDAPSPHSSKDLLDLYRQLVADGRLKWDDEQVRCIMKLRHLLKTLGSYSPPLELLAKLSPVAPFIAQQQKPRPFWWNLRDKSPSGLGIDTNSEDEKGLVRVLSGEEELANLTTPRGFCLVGPPGTGKSLLLSLFYDLLPISKCRVHYHAFTLELYKQVFEEISRNRSFEEEEYEKVMKNKEMAGRKGWKSVFAGGRWDEQGGERVMWTKEEGMTFNSDFDEFQLIDATAAALIRDVLSWYWRLGGVILTCSNRVPEDLYHHGVQRERLSGFLDALKARCEVVQVDGGRDWRLNDVKGDRTRWYKNADAGFEGAWKEATSGCKVESRTITVYGRPLKVAKASDSACRFTFAELCEEALGPADYLALVSTFGTFFIDDVPTLYLRHKNEARRFINLIDALYESRCQLHLRTPASPFDLFFPDALALSSEEQEALTNERMMSAEALSATLQVPYRPNVSYYNNLTSSQQNRENTEAKKKGSSFSVLGIWTGEDEKFAYKRAVSRLIEMTTSSAAYASEAWRPLSGTLWQGDVDRSGPQQRPLFADTQKRHEASVSKQDERPSSDPLLFKIRIKKQADALPPVIKEQHVWGVADEWGKGAGRWGQGVKAYEQVDTIAEHRRRVMPGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKT4</accession>
    <name>A0A1E3JKT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032919.1">
        <property type="nucleotide sequence ID" value="XM_019175187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKT4"/>
    <dbReference type="GeneID" id="30192266"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="179"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="293" mass="32072" checksum="376EF2B92B989C1E" modified="2017-01-18" version="1">MSYIVSVPAGRCHRRDENSKWVDPQAEKGAIQLRLEDDLLRFAWRSRENHQIDEELIIFPGEATFEKVTQDPTGRTHILKFSSSNQKYFFWFQRKNKDGDFRAQVDINNLLQDPSYQPGSAALPPQQEQDWPPTPGAPRLSNPEPAPSTSAEASSSTAPEATQENMARLLAEWARGGALGQAEDPARLTDVLSSSNIATLITSNPSLIPTITPLFPPGLSLPENPKAEDIIPVLSAPQFTDAIASLDNALRSGGLPGGMMRELGLPESAGQSVKGFLDGLLGLKKEDDRMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLW9</accession>
    <name>A0A1E3JLW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-c2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033123.1">
        <property type="nucleotide sequence ID" value="XM_019174744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLW9"/>
    <dbReference type="GeneID" id="30191812"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="202" mass="22511" checksum="C62D72E034CD5D51" modified="2017-01-18" version="1">MSEPQFFETITKSFTDVTITEAGVNTAEFLEAAEGLVKIFNLFGNPAFTVVQNDLTGNIAKIRAYLAQNPTSASTLESLIATEKANVPKPKDRVATDALMWLLRGLKFTSLGLKINLENKDEELSASFTKAYEQSLKKYHGMMVRPVFYLAMKACPYRATFYPKLGEPQAEVTVKLEAWLKALYDIVEKETTVFKAGSYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLY8</accession>
    <name>A0A1E3JLY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033122.1">
        <property type="nucleotide sequence ID" value="XM_019174743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191811"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="79"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="865"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1368"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1402" mass="157683" checksum="A4094C73D0D7EB9E" modified="2017-01-18" version="1">MSEFALQENLLALSDPSLYQIQSELDVPSLSANSIDSSLSTAIEIIAGDPDALYHSSPQTFNIFLSILKYADQPQINATVLTKLLDVIVSGLTHHSNAVMTIVNSQSFGSEADMDAPMIHKQPLEMWAFLLQWLVNAAERGAGRTNDEPRATTGRGKKKTKNAPPSTSFQFGDHLPLVLGAMHKTLRIPSSRLWRTSSEREAFISCFVKPAYQLAETEAYLKVQEIRLGIFKTICLAVKFHQHAFGAQTSIMQNLTYFEHLSEPMAELLAILEKEFDFSQLGEEVLRDVAGKSFAHNDAKGPRSFSKFLVRLAELSPRMVQKQMPLLLAHLDSDAHPMRMAIVEIIGILIRDISSSDEGDEEQKTKQVNKFFELLMERYLDLNSWVRCKVLTTLIKLCDLPAKFPKQRRQITELTIRTLEDKTSSARRYAIQLLCKLLETHPFGALHGGTLNIDEWQERYTKINEELKKVDAVELEKAKREVGVPDEHEEDEEDEGEKTEVDEYEESQESTVKTEEAGEAGEDGEAAPAKEKKKPRQSHLDLSGIQSEQTQLDPRLVNKLRLTKKYYADALRFVTQLENAIPTLCQLLVSTTKTEVLEAMRFFRVAYEYDLAGAENGIKTMLHLIWTKDNNATAGEENEGKGVRGSVIECYRSLYFDVVPDLSPKQQVNRIAKNMIERTYNATLAELTSLEELMRTMMNEGGVHSDVINKLWQVYSTDQEIPKPQRQGAIIILGMLALAKREVVTERVESLLKIGLGSLGMHDLVLARYSCIALQRLGGSVKKVKGSLTDKTMRLPMDNPIFIKLRDIIEYSPKSQSPHWFAMAEQAINTIYLLGEQPDGLCGQIVKNLTKRVYEGQKKEAAVAAEKEAEPVAEEQGQGQEEGVEGEEAAPDGEAAVEASEAPEAPETPTTPVVDAQEDKPGTTSSFRLAQLVFSVGHVAIKHIVYLELVEREFKRRKDEKAKEKAAGKAGEKDQNDLDAVAGNAEDDIGDLISGVREKELLYGEQSLLAVYGPMIAHICASPKRYRNPTLRQAATLAMTKLMCVSAEFCEAHLLLVFRILETSKDPVVRSNIVIALGDIAVCFGNLIDDNSERLYQGLADSDLVVKKNTLMVLTHLILNGMIKVKGQLGEMAKCLEDPDQRISDLAKLFFTELSTKDNALYNNLQDVISHLSIGAHAVDEETFERTMRFIFTFIEKDKQAEAIVEKLCQRFRLATEERQWRDISYCLSLLPFKSERSLKRLIEGLPFYQDKLHEETVFKRFVEILAKARANKAANKPETEMQEFERILNEHQAKGLEDQALEADVLRKTKAAKRRAAKRPAQTNTRTSRRKAATREEDEEEEDAGLEEEAVEAEEQEEVEEEEVRPKRGKKAPAAKKAPARRGRKKVVESEDEEEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMB2</accession>
    <name>A0A1E3JMB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033048.1">
        <property type="nucleotide sequence ID" value="XM_019174669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMB2"/>
    <dbReference type="GeneID" id="30191734"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="167" mass="16844" checksum="51FF42EDF2F1EC8F" modified="2017-01-18" version="1">MSTVAELCPVYAPFFGAMGCTSAIVFTCIGAAYGTAKSGVGISAMAVLRPDLMMKCAIPVVMAGIIGIYGLVVSVLISGNLTSPMPLYTGFIQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILNTNSTVDYTCSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMC0</accession>
    <name>A0A1E3JMC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033260.1">
        <property type="nucleotide sequence ID" value="XM_019174881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMC0"/>
    <dbReference type="GeneID" id="30191952"/>
    <dbReference type="OrthoDB" id="2563763at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="242" mass="27504" checksum="808AF8C0FEC71C06" modified="2017-01-18" version="1">MSNTFHSIRFALKATTISSLLILGHVLLTTAALAPYGHHHHEHHGHHDRHSHDHIHLHHAHHSSRETHSTQLAYHRALCILSALIFLTLLWFTFALLEGCDLNTTRSPPPPLLPQAIKAREDETPMVFMLTAVEVICGAVTGGAWLGNVHDRSGHSHFLPHFSLFQGSLQVAITLREIRPDDEILDIIPITYNIAFNAILLLNFHTFWSICAHARNVGVREVCRRSFWLGRIGWWEERVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMF3</accession>
    <name>A0A1E3JMF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02724</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033245.1">
        <property type="nucleotide sequence ID" value="XM_019174866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMF3"/>
    <dbReference type="GeneID" id="30191937"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="86"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="587" mass="64090" checksum="3793D188B46A35D1" modified="2017-01-18" version="1">MSIPIKSARSPSVSHLSKSPTTLNEYTSTAPQPTLPTQHKDEGVPSHLYEGLPDHFMTENAHGERIPDYLRMILMSKVYASPLNLKETPLTLAVNLSARLGNEIWLKREDLQPVFSFKIRGAYNMMASLPEAEKKKGVVTCSAGNHAQGVALSGHALNIPAIVVMPVSTPSIKWRNVQRLGATVVLHGKDFDEAKAECLRLEKEKGLTFVPPYDNPYVVAGQGTVAMEICRQVKDADEIDGIFSAIGGGGLSAGIAAYMKRVAKPTVGIYGVETVDGDAMDRSLKAGKRVTLDEVGPFADGTAVRLVGEEPFRVCKEFLDDIVLVNNDEICAAIKDVFEETRSIPEPSGALSLAGLKAHIIRNNLLNAGKRFVAVVSGGNMNFGRLRFVAERADVGERREVLISVKCPEKPGAFLKFHSLLGGRAVTEFSYRYSNAHKGHIICSFLLSASSSSPSSAGPTPQARDEEIQEVTKVLREAGMEVLDLSDNEFAKSHVRHLVGGQSEVENERVFRFGKPGALGNFLKGLKVDWNISMFHYRNHGADVGKVLVGLQVPEADYQALDDFLQDLGYPFVEETQNPAFKMFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMH7</accession>
    <name>A0A1E3JMH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033306.1">
        <property type="nucleotide sequence ID" value="XM_019174927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMH7"/>
    <dbReference type="GeneID" id="30191998"/>
    <dbReference type="OrthoDB" id="2576404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="434"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="58207" checksum="331E74FF0D7A930C" modified="2017-01-18" version="1">MPFYTTFEPSFDYAFPAQPRYTYSPFYAEPTHHYPFHTRTPTPTRQPVYESDSGLDDEEQAVLAQLAAIRQKREQLKATQAREAAGAAKAKAQREAMIKAELAQALVREQEKKRKQEEERKREEERERRAVFARAMEQANVQREKKRLAQTDAHNRQDHRAIKPVSPSHTDLNNILSALFGINLAPSDEEEEEESEHEEAEVSVPIFSPQCTSAACCQSDKPTPTDNEALVMSQLAQAIARRQAIEQEEENRRNQEEQERKQQKLEKRRAFVQAMAEKNQQREKQRLAQAQAKNRQPKPISHDNQDLQNLLNAFFGVHPPTSEDSEQSDVESEASEDPRPQRRAAPVKSEVKATAPATANAPVAPQPETTSEAAETLSPAFTILHNMDTQLAQLKSSFTFPSHLSFAHSTPNGQTPPLLFNRTNAPYHAQTNALLQLLLQADTVISEGQPEVREARKEMVKKVEAEIRSMEEKRDEVWEEVRKRRESGEEKEPDEEEERSWSDCSSVAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JN57</accession>
    <name>A0A1E3JN57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033338.1">
        <property type="nucleotide sequence ID" value="XM_019174959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JN57"/>
    <dbReference type="GeneID" id="30192030"/>
    <dbReference type="OrthoDB" id="2596969at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="38280" checksum="5DCD1296A7678927" modified="2017-01-18" version="1">MPSKDVSSAESTPPRRASTIAFEESCVLIDAYPLSMTDLEDGVKQRMSVAGASEKTWPKKSPSPRLSLTIPPALRKALPSLKLRVLPYRWSSSTPPYSTLMPTRSTHALPQPAQLSSPSAENPIPIRARSQPTSPATGNPPVRSRNPSVAEGLHMLSEREENTGHVSPNPLSGETLSPVSPTMPCAQSVWLCSPPRRHPTPPSSAPPSSFVAPSKPPTTASTRKNRPIVVRAMSTGRLAREFDQDGRVVCMSNHSNRVLQNTAVVITEGQENQHAQTTPKLRRAQTEKPAARKNLPVPLLSASTDRLPRRSSTAGFDLAALQKEAGNLARPNVLAKRVSSGFRRMSSSPQRIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU04</accession>
    <name>A0A1E3JU04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein EncT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033463.1">
        <property type="nucleotide sequence ID" value="XM_019174411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU04"/>
    <dbReference type="GeneID" id="30191472"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO03412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="535" mass="57967" checksum="2B7E201716D41AD4" modified="2017-01-18" version="1">MSTHTLRDSPSSGNSNLPKDTASDHEKAVVPADIPATTTDYHRSPLADLSQVRKNFLLLIFSVSTFIDVCNVSGAGVAVVQIANDIKLDTSQIVWIITSYSLCFAAVLLLAGRLSYLWPAQIIFEGGFLTLGVLSLVTSFVTSNKYGFLILRGLGGIAGAMTIPSSYHLTVHMFPDPAEQQAKLALLGMSGAVGNVLGLVLAGVCMLASYKWFFRVIAILCIVFTIACVTLLPITKSSYVPDPKYPRWQRLDIVGVGLLMGSLICFILALTQGPIDGWGAASFIVPFILSFPLAIGFFVWEAKIPPQSAVLPSPIWKITNIVISSLAICIPFPFWATSQLLYATYFQQVFGWKPIHVAAAILPQGIASIMAGAASQFFPQMITKARIFMPLGAALIIIAEILFIFSDGGHGMDYWRYLFPAFVLGSVGAVMSFFASAINLIQYCPPEYSGVAGGWTQVMSQVAGAITLAVQASFEGDGLMDWNKAARRSFYFQIAWTAALALQFVIFYKTPGTTEEEHEATRKRIEASGKDKGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG2</accession>
    <name>A0A1E3JWG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033854.1">
        <property type="nucleotide sequence ID" value="XM_019174047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWG2"/>
    <dbReference type="GeneID" id="30191101"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="39"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="28693" checksum="FB8BE2A01B93DF25" modified="2017-01-18" version="1">MPNDYSGLRWSVATASLSMNPIHDIYTKFDALQKAGFTYTEAERWLVLCSKLGVEQIQVGSNDYAEANAPDEKTADDLRWLAEYASKLSPPVKIAYESWCFSERVNTFEHTWKIVQIADHPNLGLCLDTAHPPLAPEYGWNPTTGEGWTAAISADSIGRVKAVPKGKDLSQTTTLSGLPLDDLYLLSEKNAGESAKDGNDMGHANALQTFKAVLDQGWSGIVMFEFFEVLRMSPADPNIPYKYANGAALSEKRLLEALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG6</accession>
    <name>A0A1E3JWG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033863.1">
        <property type="nucleotide sequence ID" value="XM_019174056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191110"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1425" mass="154497" checksum="B3F6AD4981D336F4" modified="2017-01-18" version="1">MPALPTPLPPTPTPSIHSPTMQSSAELNTSRSTIMSEQDQPIAGPSKSWQQTSYFPQPYLPPTPPVQDGEQPGSVASINFVEPVMPRRRNPSTRRPLSAYPQDDEDPIHPPSRKYTDPTPVSHLPSSDDEESGDSHQLDVDLDAYSNTGFETEEEPLEDREPTLSFVTASTHDSTAGTPPMSMAYSFPGQVEEGRDEVEPKIRLRSTAGRGANTYSSAESSIGSGPYSYHAYGDQIYQQNPPPLPQMPSGHNSSMGLGISTEYSWPANLASSQTSRPPVLSPSNTFPHRPWKRDVVTRLRSGSASSAFTVASTATDASDGSSSRANMQDGAFHYDYDGLLPYEREQAEPEALAMIKEGREKILDVEKIEALGGVEAIDQHMVHSLAGITHLLLPSCGPQILGFLSPLLSVLAPSLVVLDLSNNNLSAIPDTLQHCTSLEELNLSDNPLWNIPGWVGALVGLRVLVMDGCGISSLPEEICHLHALHSICVRRNKLVALPTWLCLLAQLDTLKVDNNPFTPEWLHIIPPILEPPPRILPAAGKRNSHHHRHLSINNGLRTPVSATPITSPTSSAGHTEQGMASGPSSSAQSSFHPAGLGPIAEDNHPHSAPIRADGEDLPFPGMMPEAQASRGLRKMRSAGALLIKMNQSVGSQSPNVRPRDLSPPTTDRFASLGGSDGRRAASAMSNYTEDSSEPTGSRLGKGSVQKPGKLGGFLRKMSMNRLRPEKDKTAAVASSASSNLKTMPALPPMRHQHSDPIKPVAIRPGMLGAMSSATLPTRKITDLHISDFGPVSHVPTGPSTMPLAGLPFPSQMGTSMSGMGTSNNSTSLHGKRRSFLPLDGPPSINVQIPTSEFPDPHAAETSVPTLTMEAPTPLATAPPSIMSQALVESPVAENDYDAKYDQGLDTIKLILRDLHDLSRKSVPHDTFAAMGGVGSADSSYTTSSVLSEHPGSPKSVGRDSFVDVHRARRPTLERDSRELSNGGGGYVDLGEKEPSLSGKKFKNDKSKRAKIIHEIWETERTYVRNLGELVTIYVKPSAKVINPNKSAFETVVPSSERKIVFGGIESILAIHRDNFLPALEKVVKTLIESEGKADDGEMSIETAYRVGEVFRTYIAYMKQYSTYITNFDNALARMKTWSGTPSGTSTPTFPGKAGSNMSSTAINAGMSAISLPAAAPTASGPQMSSSQKKRVKAFLQKGKDHPMHSQISLESYLLLPIQRIPRYKLLLTELAMCTPARADGFRDTLDDALIEISSLASLMNEEKRDADSRLRLINWQKRFTNSGRSPLVQPHRRLMFEGPLTLSRIVKKASNFAEREIMLETDGDKTITSSKTVVPVDHVVPESVEREVMLILCSDMMVLATQRGDGWEGPVNVFNVLRMGTLQEPASVTSGSTLRVVDNNSIYYFTGNTRDIIIQWCRAINTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWK0</accession>
    <name>A0A1E3JWK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033893.1">
        <property type="nucleotide sequence ID" value="XM_019174086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWK0"/>
    <dbReference type="GeneID" id="30191141"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="239" mass="25538" checksum="989EBB554CC8EAE4" modified="2017-01-18" version="1">MAATLVLPGDQIPIPSTSRNIIIGPGIAAADNASPSSAPALVATRLGMLHTGKGKEKSQKVWIEGNSKRYIPAQKDMVLGVIIARHSEGYRVDLGSAQMAQLDALSFEGATKRSKPNLKVGTLVFARVISASRDMEPELECFDANTGKSDGFGELKGGVMINCTLQLCRQLLNRNYPLLPAIASAFPFEISIGLNGRVWLKAETVSETLAMKRVIEGVNDGVLGVEEAAVKAKIQEYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWR9</accession>
    <name>A0A1E3JWR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033964.1">
        <property type="nucleotide sequence ID" value="XM_019174157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWR9"/>
    <dbReference type="GeneID" id="30191214"/>
    <dbReference type="OrthoDB" id="2596611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="178" mass="19413" checksum="78E10CF3035FA96A" modified="2017-01-18" version="1">MTQQQHQGLFASQPQAQGQFPHLARPLFASTNSTPSPSAFSKPLQTHQHQAYTAPSSPAFAPRPQPQPQSASSSRLRPKALKKSSSSTGKHRNVQTSLEVKVEKAKGFQAFFVPLCKGGVPPAPPCSPVLGHRETQRGVSEETESAGSPDYFGAWTRDGGKEREEWVEDVEGMDVDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWV0</accession>
    <name>A0A1E3JWV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retinoic acid induced 16-like protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033871.1">
        <property type="nucleotide sequence ID" value="XM_019174064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWV0"/>
    <dbReference type="GeneID" id="30191118"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121005" checksum="91A021C63085F2E0" modified="2017-01-18" version="1">MEVSSFFTRLLQTPKQQQPTAAPDSLQVFDRAWLDIKETLERPDERQLVRGITSTQVPNHLRHIVDALVYESNRTDEEQVRTGVSLADTTGACLEYFLKNDILANLERLCERDRPHGIKAEVLKAINNLVVLLSERFLIHNAVHRPLRRLLRSCIGDEPEEKVDGGARVVGAAGMSDMAERRAGNEDIEGDLVDLMCVLCSKMRAYPPLLLIFFHDKGWLQPGRSTDPAHKRVMSPTPSTMSNPSTKASTKAQHSFEFLLFSYLLRFVHREGRLGDFARAGLIFLFDIAFLTANEEGGENLSMGGKDGVDPLQDARDVLGEFILDGDFADVMAAALGAVYSMLPTKLRVPSLASRQMSDEDDKGTTAGGMFLGSSLTVDEDEFDMPSFTDEHVQFQLDLLLKLFGFLQDIIHRCNSPLLHADPASSEVSSTLVLGGAIVESTLDAIQSSFLDNVFYPAVLECSSLDGSSVAILTYLDAIFSNVDDGPVLDRIVSFLMDTNATGPSVAVPAAAPMSKKEKRKTGAMGFMGQLTTTTDYFAAEGRFTLKDLILDNLRADDWAATSAALRLLHTLFSEHSIQSTKGLLSFVRDSAATALARKSIPSELNLLPPGESLLPQSVNFVDIQLQETGLYGSLLSHIDPSQGSIELSPGFAGYLTDMQSALEANPSYRLSQYRKALPFIPESEKARVSRHIIDADPIQHRLSPSDPLLRTILHEFERFLEKIPDENVAMTGVLTSLALCPERSLAGWMLYDKSERGEVDPWAKVDREAGSESLLSDADSDSDDSMSDEASSAPNARASLSLPALYQVLRSLTKQLSYIRSDILEDPDLFDRLLAERRQGLLFKDHLDEAMNVMLDVDTFSPSTLFGSPAPGTPNTPNTPHNLFQNKLKPRTSGLASSIKSFLTPKKKTPGNTPSGTPGFLSPTGRTPSLASGLGLGMALGDDDRAPETPPKDPSTIPSPFSRPAFTSAEPPGQSAAPFKSHYDQTLQTLSLSDASSGEVIVQGPWAAPAPSYNVRHRRNRSVKDISMAGDDAFTQTTGDRDEIDELGELSMIAGEEDVGEEQKERKQVSLSMVLDNCVILEEFLKEAVAVVVARRSMGVDQVGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWV3</accession>
    <name>A0A1E3JWV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033999.1">
        <property type="nucleotide sequence ID" value="XM_019174192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWV3"/>
    <dbReference type="GeneID" id="30191250"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="39033" checksum="DE86A4E15293D867" modified="2017-01-18" version="1">MSDNRQESEQDLQDSLGSALETSFSIPPPPPKPAAPAASEVKEEPAAAAPSEPIPGMAEWPETYQGYLDEWHAESAIARAKAQETHDRIEAERLAEQKAEEDKKKAAKKAAQDEEKKKKDAEKLKAELEEEEKKETEKDVRGHGKVKEAWELVGKKDDGRDYGPFAEPLDRQDALAAQAISEAQERHEIKPAAYDPTTSTDPIPPAMQDPKPVTPAPVPTESATLSRHSATSQAWEEVSRQSDSGSGEQVSAPQSSGSDDIIQIPSPEKAAEAGVPLPPTQPPSLTLSVFTNSASLSVSKIFAVIGINLVLPFINGVMLGFGEIFAREVLKVGKEVWRGERGIFGGRRGTGGRGTSGVGLSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWZ3</accession>
    <name>A0A1E3JWZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034039.1">
        <property type="nucleotide sequence ID" value="XM_019174232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWZ3"/>
    <dbReference type="GeneID" id="30191290"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21566" checksum="9FA6E9AF7720122D" modified="2017-01-18" version="1">MVCVFTFNEEVQEEELMDGCTSSLARVDKAGYAGPLGTIKGAGWVTEMIARLNNTYPTQIASINSTLSSSPSTFPLESPIYLGFGHDTTLESIITAMGLLRPEEAYSGNMTLEKIDEGRKWKSSVMAPMGARLVLERMSCSGSSAGGTYVKMILNDATLPLKDLDACATSWGAVQGLCSLEAFNEGQAYALAGAGFSNCSNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX53</accession>
    <name>A0A1E3JX53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034099.1">
        <property type="nucleotide sequence ID" value="XM_019174292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX53"/>
    <dbReference type="GeneID" id="30191350"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="60186" checksum="2B0173A87DE0520C" modified="2017-01-18" version="1">MNEDQQADNDALASAVAAAEAAEAHQLSLEHPHHFHHTLQQPDFGQHKDGDEHELGVHGLSIPTVDDHHQHHLDQHGELDLQNLGGMGTPGDMGGLDMGDMEQQHEVYSSGRPPSIRKACDLCHAAKQKCSGDRPSCTRCSAGGWPCNYAPRQRRRTVPKDQKHHHHHQHTHHAAAHIHHAMDMQQHQPMPQSKKRKLTRDAIPSFGGDGMDMKMAMGIAMDMGMGVEEENEELQTMTDEQMLESIAIDGYLSDLPLGSFVHNLPYSTSPDHVFPDDFPSASSDPFPTADMDQHTTSALRDAIFSLNESSAAGTGQEGEGNGEHGESGETGEGEQLDPHLALLDLSNMNGENEAAEGHDPTSGLNLGDFSPQGCNHRQLVPHILSLLTQHTLDPKQGSNTPLTLAVFAPLARSLRLFNSLSICPTCLSSPRETLPQLSLLSRTTTLLTFPHPPIPSSSLGSSAQITIHGARISGTGLSEAIEQHIVGVVWDSWRASVREVFHALDKKAQEVITASAHAAMHPGEGQAVGSLEKQRAGLIFQAVSRLVTAMDEVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX91</accession>
    <name>A0A1E3JX91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034031.1">
        <property type="nucleotide sequence ID" value="XM_019174224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX91"/>
    <dbReference type="GeneID" id="30191282"/>
    <dbReference type="OrthoDB" id="2538110at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="194" mass="22070" checksum="C4790159CF73933B" modified="2017-01-18" version="1">MSNPYEPIPSRSSESSSGSSTSSNANTHAFPPRARQPVRPQTEQERERLAHFEARFERPPVAWWKRALLIVGLIAMMWASIWLGRRGRNKKPEIIYASRYSDEFKYRPAASPVITEHLKDGRIRLRGASIGGVGVKENDIPLTPAQKEKKDKERREEAKNAARAKMGLKPKQKKKEPNIYDVHKARAEEAGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXB4</accession>
    <name>A0A1E3JXB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034051.1">
        <property type="nucleotide sequence ID" value="XM_019174244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXB4"/>
    <dbReference type="GeneID" id="30191302"/>
    <dbReference type="OrthoDB" id="2575809at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="39277" checksum="3FFE5E7F296978EE" modified="2017-01-18" version="1">MSHRSQLSSLEAQLSTATHELELATFLNKGILQTNTEYKLRIGELESENAILRTAEGKLGDMEDFLEEREKEMEDLRAEVERGEEQRERMEADVGQAIERRETAEKERDEAVRELDGERRGREYWERRYAELAVLTDQYCTQIRKARGEYAELDVFGSRGALPSVPSSLPKERGKKHIPAANGAISSSSKKPRQPNTTSSSASRPSGSKSTHPPVASSESPQYHSLQNTSSPPKRPVREAVKKRRRIAESDDEYEEEQAEEYIPSLPRGVKQEPVDQQTPSRQVQPPAQRVPFSSKSTKSRNNPTYSDPRKRTAEEILGPAAKIKVKKEPVSQRYESTEEDTDDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYF3</accession>
    <name>A0A1E3JYF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_01927</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033892.1">
        <property type="nucleotide sequence ID" value="XM_019174085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYF3"/>
    <dbReference type="GeneID" id="30191140"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="211"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="400"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="53"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="678"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO05237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="761" mass="84174" checksum="6BC896ABF8B61F74" modified="2017-01-18" version="1">MPADFITTIDSDDEVSNYGGEASNAKKDDDINPDFEFDFGGGRSEGLDLWGGDEIQGVKKGNEPINVDDIIERRLGKPIKAYKDKKRRRQDSDDESDDESEQDDSEESEEEGDDEAELEGEFEGFGSENDEMEEEDSDEEEEEEGDSSEEEEEETAAEKARKEAFFSSEPKNEEDPTLPSTFAAMNLSRPLLRALTSLQLNTPTPIQSRAIPLALLGRDILGSAVTGSGKTAAFMVPILERLCYRDRGKGGAACRVLVLCPTRELAVQCEAVGRALAEKGGLDVRFALLVGGLSLNAQAHTLRTLPDILIATPGRLIDHLTNTPSFTLSALDVLVIDEADRMLEAGFTDELEEIIRACPRSRQTMLFSATMTDSVDELVKLSLDKPIRVFVDPKRNTAKGLTQEFVRIRSDDTRSPSLLALCKRTIREKCIIFFRSKALAHQMRILFGLYGLKAAELHGNLTQEQRLQSLNDFKAGSVDYLLATDLASRGLDIKGVETVINYDMPGQLAQYTHRVGRTARAGRKGRSITLVGEADRKMLKAAIKQSDADEIRHRIIPSEAVQAVAEKLETLKEDIQDIMKEEKEEKLMRQADMELKKGQNMVEHEAEIFSRPARTWFQTEKEKQNAKTASKDAYVGTFPKAKGGEKDSKDAKEKLKRGKYDGLSRRLKRRKMAIEEDAADAAASRAQDIAIRSAKKNAQPKKIGEAQPKKVDKKGKKGKVGGGKKSAFDDGKKSHEGMRAKPTKVNLEKGGKKGGKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZA4</accession>
    <name>A0A1E3JZA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034203.1">
        <property type="nucleotide sequence ID" value="XM_019173498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZA4"/>
    <dbReference type="GeneID" id="30190548"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="151" mass="16758" checksum="597BBCE76BB45D08" modified="2017-01-18" version="1">MAKVPRSFRLLSELEHGEKGIGDGSCSYGLKDGDDIAMYEWNGTIIGPPHSAYENRIFSLSIICGDNYPDVPPLVKFESKINLPCVNAQGLVDFARIATIARWNRNFTLETVLVELRREMASPANRKTSQPPEGVEFPPVDLIALARQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZD7</accession>
    <name>A0A1E3JZD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034235.1">
        <property type="nucleotide sequence ID" value="XM_019173530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZD7"/>
    <dbReference type="GeneID" id="30190580"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="60107" checksum="D22249CACA173252" modified="2017-01-18" version="1">MSTTTFNIPKPYQEPACHYELGTPERALLQEALQEILDHGPYEVPCVVDGVEVKTGNIAQQVLPSDHKHVLSNYHQADAALVEKAIAGALKAKREWEDVPFVQKTSIWLKLATLVSGPWRYKLMAATMLGQGKNAWQAEIDVRQELADFFRFGPDIVKTQYESQPAINDRGHWNRIEWRALEGFVGAVSPFNFTALAGNLVGTPLLVGNVVIWKPSDYSMLASYMVHQLLLEAGVPPSAVQFVPGPPELVVSTMINNKNFAGLHFTGSSDIFKKLNQDVAANLFKYRGFPRIVGETGGKNYIILHKTADIKTTVPQVIRAAFEYAGQKCSALSRLYVSKSLWQAGFKEHLVSEVSKIKVGPETEWENFVNALIHKGSYEKVSGYVKKAKDAGGEVLVGGTGDDSKGYFYQPTVIETKDPKSVTMVEEIFGPVVTVYVYDDEKFEETLTLVDDTSDYGLTGAIFADDRKALVLAEERLRYSAGNFYLNDKCTAAGVGSQPFGGARNSGTNDKVASPVCFSRFMSPRVVKENFVKSSEWSYPSNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZR1</accession>
    <name>A0A1E3JZR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01562</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034430.1">
        <property type="nucleotide sequence ID" value="XM_019173725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZR1"/>
    <dbReference type="GeneID" id="30190775"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO06330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108790" checksum="72151DA3B712A33D" modified="2017-01-18" version="1">MLANAWTFTPEDALAHYGTNPETGLTEEQVKRNREAYGENVLPESAPTSLFKLILAQFQDQLVLILLGSAVVSFILALFEDAVEPGGSWLTAFVEPAVILLILIANATVGVVQETNAEKAIDALKEYSPDEALVLRDGRPARVSASQLVPGDIVSVHVGDRIPADCRILSFSSSSFRVDQAMLTGESMSVGKIDGTIKDAAAVKQDMLNILFSGTTVVNGAAKAIVVLTGSETAIGAIHSSISKDDEEEEKTPLKRKLDDFGDQLAKVISVICILVWLVNIRHFNDPSHHGWLKGAIYYLKIAVALAVAAIPEGLAAVITACLALGTKKMAKRGAIVRNLPSVETLGCTNVICSDKTGTLTTNQMSVSRFVVSGEAGLNEYVVDGTTFAPHGVVTGANGSTISKDVLISANVRKLAEVCAICNDAKVTYHHESQSYSNVGEPTEAALKVLVEKLGSDNDAFNLSLATLDPLSRASAVNDYYESSLKRLLTFEFTRDRKSMSVLASSPAGTSLLVKGAPESVIERCSKILLPTGVQTLTPELKQELAQKQLDYGYKGLRTLALAYVEESDNDVSHYKSNSADDYIKFEQDMTFVGLVGMLDPPRPEVRGAIAKCKTAGIRTIVITGDNKNTAETICREIGVFGNDEDLTGKSYTGRELDALSHEEKVAAVQRASLFSRTEPSHKSQLVDLLQGLGLVVAMTGDGVNDAPALKKADIGIAMGTGTDVAKLAADMVLANDNFATIEKAVEEGRAIYNNTKQFIRYLISSNIGEVVSIFLTVLLGMPEALIPVQLLWVNLITDGLPATALGFNPPDHQIMKTAPRSGREPLVGGWLFFRYMIIGIYVGCATVFGYAWWFMFYTGGPQISFHELTHFHQCSSIFSHLDCSMFNGLPAQRATTVSLSILVVIEMFNACNSLSENESLFVLPIWANPYLVGSIVLSMALHFMILYVPFFRDMFKITALNREEWIAVVVISFPVIVIDEVLKFISMRLAKSEQRALKEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZS1</accession>
    <name>A0A1E3JZS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034440.1">
        <property type="nucleotide sequence ID" value="XM_019173735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZS1"/>
    <dbReference type="GeneID" id="30190785"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13384" checksum="5BCD0C026BC272C2" modified="2017-01-18" version="1">MSPTATPVKDNNAPSPTITPLHDPSHQAKVIPQTKPLGASNPNIVPGMATDGAAPGLGHKALLSRKFAKANKATISPTDQIQSPCTAKLTSAKQRHFTKGKPASLAQSFVAIRESSSASSPAPAGRKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZW2</accession>
    <name>A0A1E3JZW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034504.1">
        <property type="nucleotide sequence ID" value="XM_019173799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZW2"/>
    <dbReference type="GeneID" id="30190849"/>
    <dbReference type="OrthoDB" id="10331569at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10899" checksum="FD46D65835D38A6D" modified="2017-01-18" version="1">MGSRQDVTGQITLESSLLSERIVFCSLLVLTLFLLLVGFITVTVIWYRRESARKRETRHKPEARWGPWSEEEKRFVKRSRSSSLIFEKDHASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Q1</accession>
    <name>A0A1E3K1Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034467.1">
        <property type="nucleotide sequence ID" value="XM_019173762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Q1"/>
    <dbReference type="GeneID" id="30190812"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="49" mass="5508" checksum="24DEFDDAFEAB4BA0" modified="2017-01-18" version="1">MTIDLRPDLVVEIPIPSVCKLMKNMKNIKNMKTGGRELLEPHMMGAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Y5</accession>
    <name>A0A1E3K1Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034651.1">
        <property type="nucleotide sequence ID" value="XM_019172925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Y5"/>
    <dbReference type="GeneID" id="30189966"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="422"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="611"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120367" checksum="987B681D99AE7866" modified="2017-01-18" version="1">MDLTNFISDNVVRILGSSDSATVDFVQSLAVSSKTPGDLYNSLLSTGMESNPETQAFAAQVHSLVPRKTKAKAPKADKASASNHKYSFLTDDQAGSSSKKEKKKKKKEKDGGETVGVTKAKHVRKRETEGAWDSDEEEQEPKRARTRSPSRSPSRAPEETEEERLEREREEDLRERDAFAQRMKDKDQDRTKSLVTDRTSKSVGGIEAARRRDIMDDPEQRNAAIADLRNRSRQEYLSKRELQQLDLLKLELEDEKILFRGQKMSRKEEAELERKKELIRLMEERKKIDDGTDGYMLPDDYITEQGRIDQKKKKNALYKRYDEGKLVEGQFVTDVDQWEASQQDRTNLITGALDKEVLVENYDYVFDEAQKIKFLEEDKLDGTLTKEAQALLDQVDQLQNQAKSMQETRDSLPIFEFRDDLLEAIAEHQVLIVVAETGSGKTTQLPQYLYEAGYCKNGMKVGCTQPRRVAAMSVAARVAEEMGVRLGQEVGYSIRFEDMTSDKTALKYMTDGMLLREFLTDPELSGYSALVIDEAHERTLSTDILFGLVKDIARFRPDLRLLISSATLNAQKFADFFDQAPIFDVPGRRFPVDMFYTQQPEANYMHAAVTTILQIHTTQPKGDILLFLTGQDEIEAAEESLKETMYALGDKVPELIVAPIYANLPSEMQSKIFEPTPEGARKVVLATNIAETSITIDGVVYVIDPGFVKQNNYNPKTGMSSLVVEPISRASAQQRAGRAGRVGPGKAFRLYTKWAFKNELLEDTIPEIQRTNLSMVVLMLKSLGINDVLNFDFLDKPPAETIIRSFELLYALGALNHKGELTRLGRRMAEFPVDPMLSKAIINSETFHCTQEVLTIISMLQESASLLFRPKDKRVHADKAHKNFIKPGGDHFTLLNIFEQWAESNYSQQWCYENFIQFKSLSRVRDIRDQLAQLCDRVEVVIESTPNDVVPVQKAITAGYFYNTARIDRGGGYRTTKNNHSVYVHPSSCLVGMQPPPRFILYYELVLTSKEYMRQCMPIEGSWLSELAPHYFSKGEIDQLLGSASKVKMPKRVEQPKVGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K227</accession>
    <name>A0A1E3K227_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase 1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034701.1">
        <property type="nucleotide sequence ID" value="XM_019172975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K227"/>
    <dbReference type="GeneID" id="30190016"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="636" mass="70175" checksum="6CB9B28F394544BF" modified="2017-01-18" version="1">MSSKKQTSFEPLDPTPLRPDGRRVAYFYDHDVGNYHFTLGHPMKPHRIRMAHNLVVNYGLADSDDEMEGLEEEGSRQLNGELGMVGEEGKWNTAGLRGARGRGVQILRPQRATKMDMTKFHTDEYIQLLKDVMPENADALTGNGTRCLVGSDCPAVEGIFEFASISAGGSIAAAERLNSGAADIAINWPGGLHHAKKSEASGFCFVNDIVLGILELLRFNSRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHLYGNFFPGTGQVKDVGLNKGKNYAVNVPLREGITDEGFQSIFKPVIGRIMEHYRPGAVVLQGGADSLSGDKLGKLNLTLAGHSECARFLKTFGVPLMMLGGGGYTTKNVARAWAKETAVALGKELAEDLPNNQYMEYYGPRYKMEVLASNADNYNTPEYLDEIKQQIFQHLKDLPFAPSAQMKCTPSIPVARAIGLRKEWDVEEPEDQLDQRLKKLLAQRNLDGLYSRDSGDESDDLIPRTSRSKRQGVSRPSRSSTTVNGRRKRYYEDAAFEDVTEDPCGVSSRKANGSQDRRALAGRDVEWPTPPGTASNSRDGRKGNLAGTRLASQRPTPESDDENDNEDHERGTPPKKERVGKRSFFAAARFGAGASTRPSVSSVVSEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K279</accession>
    <name>A0A1E3K279_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034755.1">
        <property type="nucleotide sequence ID" value="XM_019173029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K279"/>
    <dbReference type="GeneID" id="30190070"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="319" mass="34713" checksum="0AE19E91D7FCF249" modified="2017-01-18" version="1">MGREIFDITLGQLDNTSTVHASYEEADAGEEEGRVESFPSRRGPDVFSSSFYALQLIDLALFTSRKEQLAAPESPNFAVLYAVNVPVTQLGSSPSKKRGGGGIKRTLGSVSMIALFHTSRSCSAAAAAACSLLVIFICTALPVPPQLPIMSFPFHPEAFALLIATLAEDPPAFRSLKDFAACHRFPPLPALNTSTYAGVRGARAFQHLAAGHRYTPECHVDGRQFRAANLDSTRWFPPPMKPVCPAAPGHNSKYFEPSCHPELSSTQSWYPEPSCHPKLSSTQSWYPEPSCHPKLSTQSWYPEPSCHPEPSCHPTVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2D7</accession>
    <name>A0A1E3K2D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034648.1">
        <property type="nucleotide sequence ID" value="XM_019172922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2D7"/>
    <dbReference type="GeneID" id="30189963"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="757" mass="83844" checksum="4FB907BEF4919448" modified="2017-01-18" version="1">MPKEQVRKRGKRKTKAQEEEAPAPVVAPTTHVADPEPSTSTGLHPARAAMLAGRPMPRQAPAPEAPRQEGEEGAEGAELAEGDGIDGQADWTRGPRTESEFPFGILDPDVKAYFRSIEDQIKDWEGVSSAGEEREADRQIFLSSVLSELRGHELSASTDPETSIILERLLPSLNDWGRRVIGDSFGDKWDVLLRHRFSSHVVQTWITLAADTLDREARDVWPPQQASQDISSGQLPTMSDLITSIVSLLLPSIPQLVSSPYASPPIRLLMLVLTPKRALPALGEGQGDESGIIRSKRSGKWRKGQDVKGKSILGEDVPKDKSKRKLPKELKSTRKEIRVALMENLEAAEWKAMAANAVGCPTVQLVLEFEVDDKEVEKEGSLFDTLTEGLVSQLASGKTEFEAQPFLLSLLASQTGTRPFESLLQLSPAPVFGALWKTYFEGKLGKLAGHPYANFVVAKGVSRLGKDQVEELIKEVKGNSGGRGLIKAARTSVIQALVDRSLTIPEIQKPVLQLIFSCLELPATSQNTLVPCLMTLKTFPMYQALITGEPLPLSAWQNRRTARPKDDLAPNIQGCLILQAMVGMGQANASVLDSLTSLPVDALITYAKSPIASRLLDKVFIDPAAPIKYRKKLMMVFMDHYKQLVEDKLGSRVVDTIWDRADGFMKEKIARSLIPHLTSLGGSQYGKYFVRRADIVLLNRRPEEWREKILALKHHFAHQKEPAEEVKSEVKEKKRKEQRDDIDDLFDAAENKKRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2X8</accession>
    <name>A0A1E3K2X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034967.1">
        <property type="nucleotide sequence ID" value="XM_019173241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2X8"/>
    <dbReference type="GeneID" id="30190282"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="262"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="844"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121322" checksum="E7A878EBC724DAD1" modified="2017-01-18" version="1">MAAVSLTPPSPTGPSNAALRSRLASPTISRNPSSSSVSSTSSIQAAPMRPPPPETRTAATDKSQMGSRNASDAEDDAHYDGPRTGPAGGRGGGWTRNGPRTVTSAANLSQSPQPRYPIPPSIITSSASPSPILTNRSRPRHEGAGGSPTTPRGASFAAAPDATLDGSAPLRVTISIDPEDPHNHTRHPGSGAASPLDTRGRLTAPSSPVNSNRPLDGKPRTLSVDAGTSRSHGNRSRSQGRDRRQSHSSNGSGSHKPGPEDWIKEEEIGSGAFSTVYRVAPAHEATFPTSPRPPKKYAMKVIDQSFLVKHKKVKYAMVERDAMIRISEPIPMRGHRRGISSSSSAGNSSSTTVKPRKSSVNIIAPPSPNLSGHTLTGTTPTSGGKSHSRDRLSIATTSSAGSSPVLAASTGTNAQPSPGSGKALAGRRPSRSADPPEMVPEVNEVLLPTPIISEMEGRSMPPSPVREESAEGHESLHDSPQALQNPVVELGPALPSLPPSAMDSRSSSLATSDAPPLTPGARPPRTPKKRRQSLATSEKSAKSTQTVVPSGRARQHPGFIKLHSTFNDRVALYFVMSLAAQGDMYGLIRKWGSFDINTARYYAAQMVDSCEFMHQVGVIHRDLKPENILIDDDLRTKISDFGSAKIFIDPPQASKDIDKEEQGSKRSFVGSADYVSPEVLRDDPADTAADIWAIGVILYQMIAGKTPFRGATDYLTFQRVLRKEMEWPEGFDEDAKDMIDSIFNISPANRPTATALKSHPFFKTIDWSTIWTCPVPDIQTGMRAPTATLANVDMNDIFGGVFDDDGDGFEYEYDDVEPGIDHHTGLRHSPFYDAESAARAVDSFDNPDHRNVYTPTNSNQLDPPRPTYAYNTSKPLHSRDSSEASKKGNGRKLGKGRGLSHGSESSGMTRNTLAAWLDSLRFEKKAGLHGMRRTSTSGFPEHLHGQKPDQGVGRGLWGVEPLSDEEINKWAPYLHPNENILCTNRLDTRAVNSRLPAFTGSWKPRQVLLTDFPRLVFIKADEDPAEEGELLTKGKSKEKKERREREREEMKLSRGEAVFGDKGSLATKVSSVVSKNTRTLVVYTAAVDFWVHLEDAEQRDQWANVLRRLDEYMPLRFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Z5</accession>
    <name>A0A1E3K2Z5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034876.1">
        <property type="nucleotide sequence ID" value="XM_019173150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Z5"/>
    <dbReference type="GeneID" id="30190191"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="298"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="455" mass="48528" checksum="BE6ED69903C8663A" modified="2017-01-18" version="1">MAPKRSAPTSKASAAPKKAKSAASKPASKTKAPKGAIDTVKDTAASLIDTVSSAVDVAGDIVLDDGAPAPMEEAVKETVDVPALKKKGKEVKGKAGKKAVEAVEAAKPVKGKTTKAAKEAATTVDKAAKDPKNRKRAEDFMDAAGSAAKNVAGKVGEALGETLQQFGEASGMTEATEGTAKKGKKQAGNKAVEVKEAGKRKAKEALAGAEPVAKKTRSKTAAPAPAAEDDDDDVSMHGFSSSDGEADSSDDESDAEELAVAEAGRAVDMTNLPMVARDDKSVQARLKQAAKKKDTQKGTLYVGRIPHGFYEEQMKEYFSQFGDVTRLRLARNKKTGASKHYAYIEMSSQSVAQIVAETMNNYLLMGHLLKCHVIAADKVHPQLWVGANKKFRKVPRARVEKMRHEKERTEEEQAKANKKLLKKQNQRKSKLQKAGIDYEFEGHVSLRCCAPVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K307</accession>
    <name>A0A1E3K307_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034902.1">
        <property type="nucleotide sequence ID" value="XM_019173176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K307"/>
    <dbReference type="GeneID" id="30190217"/>
    <dbReference type="OrthoDB" id="2596802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="68803" checksum="7D5DEB75D10D8C29" modified="2017-01-18" version="1">MPQTLPPLSPLQPLGDMPRVPVRQIMAEFVPDAIDFGSLDEEVSRDSTVSSVDVLAETEGNGVRIIKDPHMNFLAALDNHLPAHILASQQLTTAIFWKQALDEFYDEGKNTKPIEPIFIERDPSDTMEKTFWRYVNLVLKSKGLDKNLRGEWRSCESKNGGARSWICVRKEKYRLFDTANIMLLSSSEIFLPLERDRSAPNILRVGLPIVRDAGMTGAGDGALTCFELAIASTLSLPTPSHVPPFLPLPKLKIETASSEGEGGTLVGVFTSMCRWAGIRGSKEADNQRKAKRRRVSKQGQDLSEDRFESGRRSSGSAHPSVWARLHFHGCSLSDSGRSLAHHFFGPVGLSDSSIYGWIDKDLAHPHFEDCTSISSSPPLLPLADPPLTPRATPRKEAPITTAITLSSSPTFSVSQPIDASSAVDLEFSIGSMIDRGRLSDVYSLTSKVPANHPHDLPPLVVKIMRPSTFDDAKGWAGYETGAEAVNAWEAEVELYGGALSGLQGHIVPRCFGAPRGLMYVSREWESREINFMILERVGSAVCAKDKDLPLLPLQTKLAICSLYEALHSVRIIHGDIKRRHIRRRADGSLCIIDFEGARRASNGAWGDEMLADEMEEVKAMLGFGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K371</accession>
    <name>A0A1E3K371_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-type H+-transporting ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034956.1">
        <property type="nucleotide sequence ID" value="XM_019173230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K371"/>
    <dbReference type="GeneID" id="30190271"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="10453" checksum="C5B896920FF0781F" modified="2017-01-18" version="1">MLPSAARRSLAGLIPPKIATPGASSGTTSARTAQVIDFYSKLPKGAKPAAERAGGIRGRYFEGKNASGKPLVAAIGTLFLLGYTIDYNMHLKHHKNGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3H0</accession>
    <name>A0A1E3K3H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035127.1">
        <property type="nucleotide sequence ID" value="XM_019173401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3H0"/>
    <dbReference type="GeneID" id="30190444"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22497" checksum="5D33FCF159AFC97A" modified="2017-01-18" version="1">MGLFFANDAVDLQPVSPPLGVHLNHTAQKPTTLVLKESVFSWTGDNFSVKDTEGHTVVKCSGKAVSFRDRKEISDAHGNFMFAIRNKLIAIHKTFVGEDKEGNDLFKISKKWGVGSHMVATFKNASNGQDTTLVLRGDFWGGSADIKVDNGPVVAQITRKVFNAREYFGDKQTYMVNVAPGVDLALIAAVCICFDEAKNENEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K483</accession>
    <name>A0A1E3K483_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035110.1">
        <property type="nucleotide sequence ID" value="XM_019173384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K483"/>
    <dbReference type="GeneID" id="30190427"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="32125" checksum="23718E3B7A4C8ED3" modified="2017-01-18" version="1">MPHDDPSKSRRKSKKSKGKDRAHSHHDQPAFPTTRRDSVSSSTIYGGQTGGVLYDDEQASMGTYTQATTSAPFPNPLNKTHNFGIQATPGPAQYAQGVHSFWDATVPGSATGENMATAFGSWLDGRAADARATLTREDDYTNHMRDVDVPTQSAVTNQVFSQATEFLPLLRTAVDQSGDPEAVTRFICFAETLRTLSDELRYERFLRDEMTNAQGRATDAAWKGWKMTRRGASLADGHASLDDARALWRSHEDDKATNSQDLLTDEEGEWDSMMRAIGDTPTEDILLSFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5S2</accession>
    <name>A0A1E3K5S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035381.1">
        <property type="nucleotide sequence ID" value="XM_019172439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5S2"/>
    <dbReference type="GeneID" id="30189469"/>
    <dbReference type="OrthoDB" id="2368680at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="30184" checksum="82B167CDA40858FF" modified="2017-01-18" version="1">MQQGCGEAWSGMGGGLGLLGPDLSTWPAVVGCRMVSKDVWVVDTECSRTDEESVNGEVAIHKERFLILEATGEVIASASSARPVQQHESDNVIEGCRVRPDWFARIQQGDASHPLLQMIKTKEEDAYPAGISKSWQSRVGNDQELLKTAERAVLASCALNSTSGCKMTAVEMDAESIGKSTVVPRSKAGERVALYLPESLQVLSVHIPLEPFHPALAQVHRQTGHSQYVLRDTGQIVGNEDGVAPLWQGLLGCDYAGQRDDKLAESFWQGWEERLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6P1</accession>
    <name>A0A1E3K6P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035713.1">
        <property type="nucleotide sequence ID" value="XM_019172771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6P1"/>
    <dbReference type="GeneID" id="30189805"/>
    <dbReference type="OrthoDB" id="2563623at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130844" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="167" mass="18327" checksum="8C7968D9579D9F5C" modified="2017-01-18" version="1">MFSTSITLYALLSTALLPYVAASPAPDMIFTLKESFFTPLGCSTTFRPTSILHQVPSPQACFSRCSSSQLAAYTSPSSSSMSQSVLCACGSEVMMEGIGRMDRCKGNSWYLYSNEEVDELVIVEDDERMDKLSVFSRKGEKSSSKGPMPLAILKKLTAASKNRIFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T7</accession>
    <name>A0A1E3K6T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription elongation regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035636.1">
        <property type="nucleotide sequence ID" value="XM_019172694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T7"/>
    <dbReference type="GeneID" id="30189727"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000044">
        <property type="entry name" value="Transcription elongation regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000049">
        <property type="entry name" value="TransCription Elongation Regulator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="4">
        <location>
            <begin position="423"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="778" mass="89105" checksum="A4285A64A3D077C5" modified="2017-01-18" version="1">MSGLPPPPPPGVPSSKAGFRGSSNFPAFSGPPPGMPPPVNYPPPLLPGWTEHRAPDGVTAYYYNSQTRESTYVRPAVPSYPPPGPPPTSAQALPTEKKKAKKEKAKEKLPIPGTTWVRVITNEGNVFYFEKEAKRSEWTVPEEIKDAVAELHLQEKERREEAKRQEGQKLEQERIEKLKELERMRSDLEDEKRRNREQLEGERKRKVEEGGDDAGRGKKTKVEEDDEHAAGPEDEEDEEAWMKAVAEEFAEKDAADKKNQDEEEERAKNAEAEAAKKVFAVPEKVNVSIEEGRALFKALLIEKDISPFAPWDQSLPLFINDPRYVLLASMKDRREVYEEYCREAGRAKRLNKTTTGTSEKKSSDPERDYKELLEREVTSTRARWDDFRKNWKKERKFYAFGRDDHQREKVFKQWLRDLGEKKRLAAQRAEEEFTTLLKESKGITISSSWSSVKRSLSSDPRYDAVGSSSLREELFNNYIKALSSDSAAAEPQRAGNQSAPAETKEEVAARKTAERKAKAEASLRDREAKVREDRLRMEKEMNKSKVGAGREEAERLFGSLLVDTIRDHEVSWQDASSALSSDPRFDHPALTLGNKQRLFHEHIARVASKRSGALHQLFETHTPGLDTPYEDVYSRIVDDPIVKRLGLQGGTLEDRWKAWLRTRETQARREFAEMLGENSFVEFWGKMRKKTLDEKALEVQEQDEWDEGEGMGEGGAADLTKLARQIDLGEIKSVLRRDKRYRLFDHVPEEREKWLRDYLENVEAASGSQTIHNIRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Y6</accession>
    <name>A0A1E3K6Y6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00564</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035686.1">
        <property type="nucleotide sequence ID" value="XM_019172744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Y6"/>
    <dbReference type="GeneID" id="30189777"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130848" evidence="13">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="32916" checksum="8DB55F19773DA85E" modified="2017-01-18" version="1">MFSSAKLSLALLSVAASASAHIALWHNASYGYDDSQPNQSDLVQPLQNLTFDEWWFHGKIDSPPADGAVMNLPSGGTFHGEVACNKALTTWGGAPSRQTEYACDAVGVLHTTDEFGEEPQDVKGCGIGIAYKSDVEDITPEDFTIISVNHTCPWKRNVDFQIPSDLPPCPTGGCHCMWGWIHASDAGTEQNYFVGYRCDVVGATGSIPLPQAKVANKCPTDTSNCTVGAKQPHYWLQAEKNNNFQDNFDPPFYNGDYGFSDGAQTDLFEGHSSKRSDVESQKLRDDTRRSRVLRRSVGGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Z2</accession>
    <name>A0A1E3K6Z2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035809.1">
        <property type="nucleotide sequence ID" value="XM_019172867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Z2"/>
    <dbReference type="GeneID" id="30189906"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="22654" checksum="2DA2E37371789DE6" modified="2017-01-18" version="1">MLKEEQEKRARAAASAAKKAAKASASGSSHRPSSSNPTKRTAEVSSAAGSSKKARVNSNPPKGLKKGVKSRDIPVANRLVSASATGNGEHPVDSSSHGPSSSTNAVLTCPCSDASRTSQARASAATINLVQLEQAFEIYQSKLSKLCKEQRQAGTLTEADENQKFNCVNELIALNDLRDAEDPTILYQKWQDHPEDFWVTSRGGSVWGCRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7D6</accession>
    <name>A0A1E3K7D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035770.1">
        <property type="nucleotide sequence ID" value="XM_019172828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7D6"/>
    <dbReference type="GeneID" id="30189867"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000192">
        <property type="entry name" value="Vacuolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="758"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="829"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1169" mass="126839" checksum="93F399F5F53203AD" modified="2017-01-18" version="1">MPARDPNASPLAPSTLPNHPASPTSSHYSSILSPPGTSGFSTRTHQSFSGGLSSPPTPEQQQQQNNGYFAQALRRVSGGAASGALPKMDAGSLSGQEIAAAGSSGWEDHSFHTHVGSTTSQAIRDSTARLASMSYSSRPRAYSSTSGGGDSSFPLHPSQSTPHSRHGSVNPSSFREHRPVHPSHLNPAAQKGGPTPVPEVDEVADFSPPKTAQGVPASPYGNAQSGLSMMLKRDNEDRRVKGLGESVSPENRGYGATATSNEEDLSGERTPMPRKTPLAELPPPIDTPDTEIPHAASESSLRRYLEAGQGELGQSHDESSPLLGGERKPRSWGGEVLANIGQLKSQAGKLTAKDVVQGAVIEPIKTLPSVILGLLLNVLDGVSYGMILFPATPVFADYGSLGVSMFFMSCVVSQLVFSLGGSIFPGGNGSMMIEAVPFFHILVTTFEQVIGDDDKAIVATTMAAFAFSSILTGLVFFALGAFKLGGLIGYFPRHILVGCIGGVGVFLIETGLQVSRGLKEEGFEYNLATLKLFFQSGHAIAIWTIPLFLAILLRIITHFFHHQLIFPAYFFIIPIIFYIVVAIGGWEIQHLRQTGWVFDVGSNTQAWWKFYTLFDLRKTHWEAFWAAMPTQLALVFFGILHVPLNVPALGVSLGEDNVKLDRELVAHGASNVIAGLTGTVPNYLTYVNTVLFYRVGGGSRLSGLMLAAATTAVMMIGPAVIATLPVMVVGALIFVLGIDLVIEAVWDTRHRVNKMEYVTIWAITIGMTIFDFVIGLLFGIILACIFFVVQSSRRRAIRAVFNGSTARSTVRRPKWQRSFIQQVGSQTYVMKLQGFLFFGTITTVEDEIRKLLDLAKWQHNPIRFLIIDFTLVHGLDFSSAEAFVRVQRLLAVKDVLMIMCGAKPDGLVGTALRGVDLWADREGTRVEVFDALNDALEWTENAYLTAYFENQRLIECEASTRVIDFPTVAKPPFSLAESFQNSPRRSHLVKAGGDVLPQSNYPKQTQETSSPESEDPLAQPVPCLLQTFGDYSSSSITPSFCSSIAPYFVRSCILSGDTLWSQGEPADGLYVIETGCLRATYEYHQTTNLIQETMVAGSIAGDLSTLSETTRNATVVAERDSVLWKLERKALERLAKDEPEVARAFIRIVLKGVAEEQDVLSSHLIAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7Q1</accession>
    <name>A0A1E3K7Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor 3A subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035738.1">
        <property type="nucleotide sequence ID" value="XM_019172796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7Q1"/>
    <dbReference type="GeneID" id="30189833"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="697"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="747" mass="83431" checksum="35963319A82E7D81" modified="2017-01-18" version="1">MSALNLPKPVNSYAGQDELRNVAPANGNGTPNGDDAQEDEGEYRPPRPSDQLKIGIIYPPKEIRTIVDKTATHISKSPTPLLLEEKIRDFQKHDPKFAFLNDADPFHQYYRYMVQKAKEDVEDAVQGIVKPQEEKKEVKVEESKAKEPKAWEFKVDMPGVTAQDLDILRLTALFHARRGRSFLSSLSVKEGRNYQFDFLRPTHSLYGYYNRMVESYSKVINPPPGLIDGLVKEAKDEGSKWKTLEEARNRAEWERGRRKRENDRAKEEEEDAKAMAAIDWQDFVTVETIEFTQADEALELPPPTSIQKLKSMSLAEKRMAAMVMEETGAGPTQANGQQDEMEIEEDEEDEDAKTQRIKAEQEQARAREVQRAAMEQRGMKIKKDYVPKGLQRTTSVSTATCPNCGQLIPEDQLSEHMRIELLDPKWKEQKKQQDLRRAQHQQLAQGADIAASLKNLASARTDIFGDDVDEATRRAREEEEKQKRREREKIVWDGHTASAAQTTETFQSQFSLEDQIKKMHSRMGLDNVPANSPGPQIGPGMSQHVPTPMAAGLPTPGGGTAYAGATISAAPTGPSTREYISTPYDPAAFGGQSPGVPPSIHPSRLAAMGPGSGTPPVAGQVHPRDDDGASAPAFKRPKIQKLPYGQLYSETDWANYHPDPIKLSVQLPVMPEKPEWKLDGSIIEVPDLPVGTLFSTVRERIKRVMDADLPISRMRLDWGGKPMSNGSTLASVNLDDEDTIVLVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7R4</accession>
    <name>A0A1E3K7R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin rerated protein, other eukaryote</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035748.1">
        <property type="nucleotide sequence ID" value="XM_019172806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7R4"/>
    <dbReference type="GeneID" id="30189845"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36065" checksum="AFF7AE3A7626198A" modified="2017-01-18" version="1">MPTFLPSNKHDLHHLRAPIPKNASPRVLAAKNHVVAMMGEFVGTTLFILFCLGGTHVAQLPALSITSSSEGAINTSSLFYISLSFGLSLAVNVWIFFRVSGGLFNPAVSLGMVLGGALPPLRGLLLTVSQVLGGLAGSAIADALVPGKLNAGCALGGGTSIVQGLFIEVFMTALLMLTIFFLAAEKNKATPMAPLGIGMALFIAEIFSVYYTGGALNPARAFGPAVVTHTFPGYHWIYWVGPGLGALMATGFYKLLKWLEYETVLQADDGQSYEDGEGPGPEARDEEAARVESTDKPRAQQPSEAVYDLQSAARINSRLARIEVLLSQVLEAQAAQAARAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K999</accession>
    <name>A0A1E3K999_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035677.1">
        <property type="nucleotide sequence ID" value="XM_019172735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K999"/>
    <dbReference type="GeneID" id="30189768"/>
    <dbReference type="OrthoDB" id="2577721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="82" mass="9290" checksum="9FE556A0A4451A30" modified="2017-01-18" version="1">MFAAIRKAADLHLGDKVGQILLSQVETDDLALIKHAMRAKFPILFADGSRFVREWPIESLLKQRLDNSKKEARRKAQETTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF15</accession>
    <name>A0A1E3HF15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000058">
        <property type="protein sequence ID" value="ODN74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027839.1">
        <property type="nucleotide sequence ID" value="XM_019180182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF15"/>
    <dbReference type="GeneID" id="30197422"/>
    <dbReference type="OrthoDB" id="10297795at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40950" checksum="EDC3DCFC7113647F" modified="2017-01-18" version="1">MTEADPSSPQRLPEDVMYVLLGHVGATASPPALATFLRVSRYFHKRLIPFLYISPTLTQANVSGFFDPLFDTDTIDDDEREHWWQGDPVDKKSAVARRLAMLGHVQCVIFEDYATEIMCNSAVSGFLAQGLDSPPMSWYGYTSSSRDDSSPARRLLFYGRAPTLVHLSHKYLGNLAFEALDDEDRRVQTFQSMLGPFGVLSIQQPADLRGLHRFYVPNYLAPICRRVEPFVLVINDYDNTVLSEILSPSQRGIAMRLRGSMDSRSIAQTDEVVEFLSEHMKLTREPLFYIIYNFSMDEAIYDHCNGKRVRNLILKRAFAAASQSPQKRIVRLEVIMQGPQSNAATVERMRYDIFELMKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HSE0</accession>
    <name>A0A1E3HSE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028098.1">
        <property type="nucleotide sequence ID" value="XM_019179922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HSE0"/>
    <dbReference type="GeneID" id="30197157"/>
    <dbReference type="OrthoDB" id="10353138at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="34649" checksum="58F681470F436221" modified="2017-01-18" version="1">MPSLLAIPGSPLFSSVTHLSFGETVSLEACHLSDERFAVKYKSFGPALKHVCLSFNDIFHDLEAEYEEAARFGDLDEFEEREPRERITKLLHKRLSFTLRSDVDEKTSLTLHNAWPDDIEPGLADTMIYELPRSTDNGEEDWERQLAMTTWEMTSYMSELQERMQDDRLGANVWRPTIKPWKIRFTNMAPIPPNTDIISAVLDDCLLVRDQHFEGLFKKWWEEVVSFEGPVKCDCCEIFKKGHPKINAYKYSYNTRRENFEIIREEAGEIREEYELFKEAEADFYDNLFALSECSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVX0</accession>
    <name>A0A1E3HVX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028209.1">
        <property type="nucleotide sequence ID" value="XM_019179787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVX0"/>
    <dbReference type="GeneID" id="30197014"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="731" mass="82157" checksum="757A3400FE99C962" modified="2017-01-18" version="1">MPSVVLPLVQTPPFSIIALAYLQGIPVSWDTTSGETGQASYGEVKGAEAVRAELEKGVDGKEIPLPPLPTLLSSTSTFQDVTAVLDALDDYLAYRTYFAGPKFGFGDATIWGTIRGNNSAIGSIKKPGRPHLQRWFTHVETLDVPQQSLKTFSQAKSEQEKGKKTKRLESVDVVLPNAVKGKVVVRFAPEPSGYLHIGHLKAAILNRYLADQYQGKFILRFDDTNPLKEEGEFEEAIQEDLKMIEISFDKIVHTSDHFDKIREYTIQLIKQGDAFMDDTDGETVKEQRRAEIPSKNRDLSIEENLKRFADMCEGTEEGKRWSLRAKIDYQHKNGTLRDPVIYRYVDADHHVVGKKYKAYPMYDLACPVIDHLDGVTHALRANEYWARHEQYQWFLKALKFPNIEIFDFSRVDFVNTVLSKRKLKYLVDKGVVNGWDDPRFPTVRGIRSRGMSVQGLKNYILSQGASQQAVQLEWDGIWTTNKKVIDPIAPRYWAIAEDKIVPATIKGRESEAVEVVKKPLHKKNPEVGEKEMVFSSEVLLEQEDAKTFGDNEEITAMDWGNAFVSKKNLASSGDVASLELNLHLAGDFKKTSKKVTWLAAPTAEKPLIPVVLIDYDYLITKKKLEEDDDLNEIINPKTEYRTRALASREVEGLKKWDIIQFERKGFYICQGTKDAEGRMEFGFIPDGRAATVALKATPAVEKPKVAGAAKGSWGKPGIKAKAEEAVAAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1W1</accession>
    <name>A0A1E3I1W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028325.1">
        <property type="nucleotide sequence ID" value="XM_019179708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196931"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="772"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1156"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1496"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1514"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN82498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1590" mass="174820" checksum="305109454B5C8B87" modified="2017-01-18" version="1">MAPFGPRQRHDPAPRQPPQQQPQNPNVRNEVFENIFGRPAVGHHQSHGPPPGQHAPPQPPPGGTYGYKPYPQQQQPSSYLLPAQPSYPPSFPAQGPPRQQPSPFAYRPQPTPAPQPLPPAEDPYDSVYGGVEGGYGNRSVSAGHPQALMPAGRRASLAPSTYSGTSSASAYSPNPNDIASPHQPTARLPSATFPTPKPRLPSGPNLQYPAGAMTPAQAYQTNVSSGYGAAQVQVPAPHGMSSGAPVAFPRRPSQPHYGSEASSSNASFASSSNPAALGRMPTSNSITSFHKPTTQSPPPPPNVERSTTPDYIGQMGHLSFENSPVKGGFQDDVANAGGREDERRDRHGSASGMARASMHRRMASDSSLSSSGHTTKPSRPVIAPLSTIDATRDEAIISTPTTPTGSVSDMYTMALLNSSRQSMESTLSLPLPTSDHPLPPGAAPGFEVRSTSFSGSTRSGEHTLKGRGSGFLHRHSHDHSNSFSISRHTSVPPATRQALSALPPIYPALLSAVAGAFKQIITLGDLVKDGITYKDSFEGRLAVAVIAEIIKTPDRNLALLLGRALDAQKFFHDVTYDHRLRDNPHELYQFKERLATPWLEGQENGGTESPKSEPGGLGRNGSGKSLNMGMGMGLGSGLRALRQARPNSDTLSMQTSGSATSLTSTPATSLAPSRSGTLGVDLNPEEDEDLPVGVFTLLTDCYSPTCSRDSLCYSINCPRRLEQMKRLNMKPEPGLTRKLSRESLHEVKETGTLWIHSVSQDILDSVDDREKKRQEAINEVIYTERDFVRDLEYLRDLWVKPLRTQEIVDLDRRDDFVRQVFWNVHDVLAVNQPLAERLTKRQQKEPVVSGVGDLFLERVPLFEPFVTYGAHQLFGKYEFEKEKGSNPDFQKFVDETERKPESRKLELNGYLTKPTTRLGRYPLLLEAVLKYTPDDHQDKKDLPEVIKMIKGFLGKVNVESGKSENIFELAQIEQKLVFRPNENIDLRLRDKNREIVHKGPLKRRGGSREEIADLTGFLFDHAFLLVKPKWVNKSEQYKVYRRPIPLELLVLVTPDESYNSSKLSHGRTRLITRHTTSSNNQAANSVAAPPRPESKHGFSLTIIHLGKKGYSMQLWVDTYIGRKKWLESIDKQQTSLREKSCVFVSESVADGSPSGLRKVNCASPYDQGNRMIFGTDDGVYFANLRDDKLKDPVKVISLIDVTQVDVIEEFQLLIVLHERCVTTFPLDSLDPSDPAAALKRGKRISSHTSFIKSGVCLGKTLVAIVKSSTLSSTIKVMEPVDVGQNKKKAQAGFMKRLNGREDALKLFKEFYIPTESSSVHFLKTKLCVGCTKGFEIVDLETLDMQGLLDPSDGSLDFVLKRDNVRPIAIYRIEEDFLLCYDEFAFYVNKNGWRARPKWAIVWEGVPTAFALHYPYVVAFEPTFIEVHHVETGHLVQIIPGNNIRCLFADTPPSRVNAPPPPNRMMYPGQAGGVYGRPPPHPGYPYPPNTAAYPHAPPAGRGYYPNPPLTSGARPRPPPQMGGYPVPHPHQQAPPGPPVNRFARSQVVFVSDESHVQFLKFPPPPTPGPQGQRGSLGAQSTTSLAGPRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I3Q3</accession>
    <name>A0A1E3I3Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028323.1">
        <property type="nucleotide sequence ID" value="XM_019179706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I3Q3"/>
    <dbReference type="GeneID" id="30196929"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="341" mass="36633" checksum="D3635CF3C9E7C293" modified="2017-01-18" version="1">MGEHESDDETDTSVSELSAYVSAESSPMGSILFGCATSFEGAGGCKEEEKYKRAEELREAMTSALLCCRLSNASLHSLPQETEPLSTHSPPLPQREARQPTRVRTQSCGAKRPMVGQGQQREEEKWRKVEGDEKDVKMVVEEAVDNGVLLSPSESAKASVSTAQGGRMSASVPALSQADAHARNPTPAAVFGMVVKTNMVGQVEEGKRMMLGSRIDVPSLLFGFAPPSASAPNPSPLQSSFRDLHLYHPSPSPSVCSTPTQTKTLGKLLLSSCLGKLFRMDAPSKGRGPVCRGLATDLRRIKGEGVRALVCCLDVEELAFLEVPWETYRDVAVGAGLDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBB0</accession>
    <name>A0A1E3IBB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028589.1">
        <property type="nucleotide sequence ID" value="XM_019179448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBB0"/>
    <dbReference type="GeneID" id="30196660"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="69" mass="7566" checksum="FAEDD688FA441A9D" modified="2017-01-18" version="1">MSTLGSTTLLVPVEVQRAIISDVLIEPSGHKPTLASVARTSQDHLDLIRPQLHESLKVLRPPAMLMISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICK5</accession>
    <name>A0A1E3ICK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028714.1">
        <property type="nucleotide sequence ID" value="XM_019179358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICK5"/>
    <dbReference type="GeneID" id="30196567"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase SUV3 DEXQ-box helicase" evidence="3">
        <location>
            <begin position="660"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="779"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="966" mass="104360" checksum="386703D52A01D74E" modified="2017-01-18" version="1">MPAEYDSYRQIWGPMVTEQLGNSTAHRLSVPTSRAYPPILSTSASPTGASTTPSLPASFGVTTTPAQQKILLLVTSVNSFTQRVLFYLTHERPLLQSAKRRPDWEKHTAEDVLRILNASDSQPGAMLHPLTSDAKASLFAYGAHLHKSAVTLPPPLFTAFGFTSFKQVPAGTPIATRLGAVLFKTAQTPTSSAAICITHGRVPRGKDKLIDPKIPMANTIKLAGHGEILDNVQGWTQETNGACTTQNCRTLLSALQWAADPSCGDVKVLAFITGDGYVSNGIAFNPIEYASSPGQETWDNICAIDDRLVAQELKTKCEVALGRVFAEVAGVEDQEGGGGYGWKGVGEEGRGKSARGDKGYDIAMEHSRLKSAAPSSQPSNGPPTPPAGMSRYSPSWAAATFPPLSPSTPSDSLPPRPRDLAQYLPHRRYRLFPLLRRFRRAAAFMQGQGKALSERGIVTVACVRWNTAAGGVALATACDVVLAGRGVGLNPSSRGMGLHGSELHSFSYLHRCGPVHAAEILREMKPLTHRSLSPMAPLSSPPWPRPESAPLPPLPPSPPLHHLRKEELSQMLLDSFYPIRSERYHICRYKFVRKSEAGSTPARYAVHEEERRQDEGDKAEFDDAPGWVRGEDPQDPAAPFLSDLCAREEDVLGSVGGLDGKERNCNIITGEEWRIVDPDSGLLSCTVEILPLGGLDGEPFNVVVIDEMQMLGDENRGGSWAKAILGTAAKDIHLYGDETTVELLRGMITSLGDTLAIHEYNHLTPLLVGDASIENEYSKIEDGDCVVTFSRSCIFNLERVIESQGKKCAVVYGALSPETRAEQAKGFTDENGLCKVLVDSDAVGKGLNFAGRAGRFKTGADKNIATLDEAPFSSGYATTFKPADLPVLRKMLDWKLPPIARAKMDIPTISLIELAALLTSSLTYGDLVKHCSTLAKLPPSIAVTDPFNKLAIADVIKTYRLSLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID66</accession>
    <name>A0A1E3ID66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_07247</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028736.1">
        <property type="nucleotide sequence ID" value="XM_019179255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID66"/>
    <dbReference type="GeneID" id="30196458"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="154"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="352"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN86553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="471" mass="52985" checksum="D34101C3FD1AB350" modified="2017-01-18" version="1">MASRLAPLIPKRALCPSILRCRASPLLTRSQSTSTPRPPYLINDRLYPTDAWSNCPPTILSKTGRNLHLLPAHPIAIIRQIIEDHFSAYTALIPETPAVSVHQNFDELGFPPDHPGRSMTDSYYLNKEHMLRTHTSAHEVESYRKGLDQWLLSADVYRRDEIDSSHYPVFHQMEGTHVWSEDELRTLPELNAKLAASLASCPILIEDTTSISSSNPYQPHHDPAHAAQIVQHLKHSLNSLIFRLFGHVVTKTGEPLRVRWIEAYFPFTTPSYEVEVWWDGKWLEILGCGVVMQKTLDQAGVSNKAGWAFGLGLERLSMVLFSIPDIRLFWSFDQRFHSQFSAGQITTFRPYSKYPACYHDMSFWLPVGAVGAVADKGAGGGEGGVGAGAAGGKGRVFHENDYFEIVREITGDLVENVALIDEFTHPKTGRQSRCYRLNYRSMDRSLSNDEVGALQKQVQERVVGEMGIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFP7</accession>
    <name>A0A1E3IFP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028983.1">
        <property type="nucleotide sequence ID" value="XM_019179065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFP7"/>
    <dbReference type="GeneID" id="30196259"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35627" checksum="2175BE7526F59A23" modified="2017-01-18" version="1">MAFPFCHLRGLARCAGESSRHPLGRRSSHVTFGSRYLTTRSDPPPPSQKPPAIHMNRSMKKPSSNVLRPPRVPTFDYKLNPQGSTHTKPKLVCTSDSIEIDDLLRTFGGNVLAVDIKYPSELVKERERGAVQGPNQGWYKQGRTTMVAIGGKNLILLVPIGPNDDIPDGIVRLLTTPSIFKVGGNILKTCMKIHRDFPHRFTPTSRPQKLLDLAGMAQDIHPHNKTWLEGIRMTVSAMCQVYIGKALTKDPSTRMEDFWGGPVTEEKIDYAANHVHATYIIFRKIQEMAFQRGLVLDPNRYLKAVELRFKRHRDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGN1</accession>
    <name>A0A1E3IGN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029031.1">
        <property type="nucleotide sequence ID" value="XM_019178937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGN1"/>
    <dbReference type="GeneID" id="30196123"/>
    <dbReference type="OrthoDB" id="10599804at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="178" mass="20103" checksum="69614FD657EB9618" modified="2017-01-18" version="1">MAPEHGAATHQQLLPDNDKRTSWVTQPTATTCSLPTPSQKRMAEMEETLGMNWVIFHQLYRQNTLLHLIHVGVILSLMRDSMKVGNLSAPVTISQYEGLLIRNWREITRGYMTFEGEAGTGSASFMLTMTVLVGPICILLGNTVYTVYCWVRSLAYWWDNRKAATTNRRVTGDQSKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IH02</accession>
    <name>A0A1E3IH02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029038.1">
        <property type="nucleotide sequence ID" value="XM_019178944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IH02"/>
    <dbReference type="GeneID" id="30196131"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="115" mass="13041" checksum="322E7974079646F8" modified="2017-01-18" version="1">MLFQDHTLLLDVASGAIQDRTPGGSYDRVLYLIIAIKALQVCLGPLYFYLDRIWLGGSLRLSEKKRLEKLVEKKEYNLDHEGWRISKLTTRVVGGELVGLVITAWVVYIVYSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHF7</accession>
    <name>A0A1E3IHF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029102.1">
        <property type="nucleotide sequence ID" value="XM_019178825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHF7"/>
    <dbReference type="GeneID" id="30195983"/>
    <dbReference type="OrthoDB" id="10602154at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="20514" checksum="CCA55CD364E8396E" modified="2017-01-18" version="1">MAFLDDLPGPLAFPLVRSPSSVQLFPSPPSPAVRVEESAPRAHSPLYLRSLRAFPLPTRIARPRLGGIDLSATLHTHSDTGTSHEGEEPSPVTASLKRALSLLAADATSLNVRRTIEDTVAVYRQYVIAQEKPSKRLSYTQPKWEKGWRGILQQGTGGVSKTLLDQHEDLLREMLIEAGTTEEKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIJ5</accession>
    <name>A0A1E3IIJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029229.1">
        <property type="nucleotide sequence ID" value="XM_019178746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIJ5"/>
    <dbReference type="GeneID" id="30195903"/>
    <dbReference type="OrthoDB" id="2576998at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Post-SET" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44094" checksum="A0A5B12A9C6C0FF9" modified="2017-01-18" version="1">MSPPIPAEIAKDRDCQMSSLEADPKYDLALPPELISLIFTFYASSTIPGSKAFTDLLCLSRAIHDENINRAYDRITLTEDNVLAFFRPWIAWAAKVKKSASSNGRSIMSQMRLDNTIIYPRAWMGYAENFDRKRSITFADTRALLETCQFKNENGSGPFGVFSYPSEEEFRKSPFYLLNNLHHVAFPSSLFISTSTSQLYQIAWEKYRRWKMYETSYVRAQHVCIELPLGPLPQVAFDGLNDMLKNTMANLKKLTVHNCSVTSDLPLLAIDPKVIFEIFMKSPRDTGMDEAHVEAIEIAQQDGLVDRIVDIFSYNENLSSCIVHHLEPHGRDSVSNIIQGLEGEGLDDDIPGLVRDEKLLIFTNEDCVAHEELECMCGLKVCRSEVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIQ1</accession>
    <name>A0A1E3IIQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029217.1">
        <property type="nucleotide sequence ID" value="XM_019178734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIQ1"/>
    <dbReference type="GeneID" id="30195891"/>
    <dbReference type="OrthoDB" id="2577488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="287" mass="32974" checksum="DB96A75A10BA4E2A" modified="2017-01-18" version="1">MKRPDAPLHRLPLPPELALEIFDTYTAMTLPGTPEFLTLLTLSRYHYALNIRRLYRDLKLKESMADRFADMWRGWIFQAMQLVAEAAERSMEHVVDEDEIVASLLCPIKFTSAGFNINTLTFQNAICFDKISELVNIPESCRWYMWEHHPSLAPNPIRLLYDAKTVVFEEQTLGGGEVKMGGDAMYARSDGNTHYGAERLVIVMPSRPFHCISPLALNWLAGLGKRLLPHVKHVTLEYRTAVVGEGATLFKKRQHRMEQIDQVESKIKRCVLNERVKKKDGRLTRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJR6</accession>
    <name>A0A1E3IJR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029405.1">
        <property type="nucleotide sequence ID" value="XM_019178704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJR6"/>
    <dbReference type="GeneID" id="30195861"/>
    <dbReference type="OrthoDB" id="10313664at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="363" mass="40100" checksum="D07B192E4A10FAE7" modified="2017-01-18" version="1">MSSLAIPHRLKTFFSGSSLETSPPESKDWNVLQVYGWDRVDSTARFDAFDPASRLGSRKATLVKNDEWRILLEDATGNAGATTAPNSASIDEFNETKQHVLSDPTFASRVTDLRNVIDVLSQGDNPSAKNGFTYWDGEYRVDGLRSGFQDGQQQGDRTQWTIRAKRNTRGAIFFNGPTLITERLEKIRKKGVLVNGNTEPIEGVDIRDYGVDNSTRSFVESATTNLDIRSFFDQQDSGRVVEGQSNSGATGWHIQKGFDHSYLGFEGEHAFALRKPEKATKGKALSRRMLGRHPEDGNVEALTGAAQLLDAAPDSAKGDCSFSYHTPSGYQATIGRRQRFMSGVEWLVSLGKVEEDSQDSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKN2</accession>
    <name>A0A1E3IKN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malonic semialdehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029449.1">
        <property type="nucleotide sequence ID" value="XM_019178542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKN2"/>
    <dbReference type="GeneID" id="30195698"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="265" mass="28174" checksum="1E641ACFC3037D48" modified="2017-01-18" version="1">MSVFNTSRLAGKTVLITGASAGIGAATAELFAKTGANLVLLARRADNLKAVKAKIEAAHKESGLKEGGRVVLIEADIQKKEDVDAVPSKLEGLEVDILVNNAGMVRGKDQVGAEDDINVMFSTNVIGLVNLTQIFVREFKARNRGHIINLGSVAGREPYAGGAIYCATKHALAAISGSLLRELVNTPIRVSEVQPGMVETEFSLVRFRGDQGAADKVYEGLVPLSGQDIAEEIVWVASRPEHVNIAQLFVLPVNQASPTLAHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM31</accession>
    <name>A0A1E3IM31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029572.1">
        <property type="nucleotide sequence ID" value="XM_019178416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM31"/>
    <dbReference type="GeneID" id="30195563"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN89663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116553" checksum="ACB6753DAD9FD8CA" modified="2017-01-18" version="1">MDIGITLDEEVAGPSSLSLPVIPQSDLEQVAQTILQLYDPATSSNPQLVKEIETGLQDLQHRPEAWGLLNGLAGHPEASVRFFAVNTTQHKIASDWNSLPDELRPVLLNLLLQTLHNSVDPSTSHYYESANALVTRKLFVAVRTRTTCLTVLIQIIYQIASILLRIELAQFQHPIKTVLELLQGSLHASRASIPPQNLPEIELKTRLLELEWCGIFIEEMGRAGLTEQRRTAIRNHIELDRGIVLNTIIRSMSIDGSASPEKQSQEATAACRCAESWIGWGLEADNLHTLVPNLYTLLPLPQASSTIVEVLSESIWKYGKGTKMLTEPLIEWTIGAPGQALVRGEPTDELIAFSKLIAALIEHSSDWFLAHIYEDQVQAFLGVVLRITGWQGTGGVEEEVSQLTLPVYSLLQESLMDSDLFQAPHETDPSWQIAKQFFSELVSVTRRKVRWPGNGEVPTGEELGDMDNDDREAFDAWRRDAGEVIVSGYYVLREEMMRNLTQIAAQQVQSGASWQDIEATIHCIRYSSEAVPLGEGENLPVLFGDQVLGLLALRQGNGPGENRLRLTVVCLIQSYEEWFKYHPSHLPLVLSYLVPSLTSQNLDISRSAASAFKAICDMCRKNLVEHIGAFADLHGKIGGMKDEEQVMVIQGITSVIQALQAADAIGPVEGILMPIIERISVATSASQSNPIEAQPVLVQALNSLTSAFKGLSPSDDDMFDTSDDPAVKEEEVAVSREDPRIVALRERIYLSVEGAVGVWNGDVEVADALSSLLKNVSQKPPTLISLPPLPLLNLVTLVGWRAPSALWFSIASTLILSISAPPSFFSKKKKDMSTEEEDVRKTVEEEEKWQTVGNAGGRLVEAAQMAFQGEGMKEHPDIVEGWFKFCHSLAERFPGVLLRLQPQQIEAYIQLGLAGLALQERFSLKSASDFFVALLSKTRNPSPLENIMEPLLDAFGPALLRALILSAGSEGPRSVIPNLAELLANLVTRVSAQNLAPWLDGILGVDGFPDVRATPESKKKLKDAVLRSRTTRRMREALHEFALVARGLEGTTYGNATAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM80</accession>
    <name>A0A1E3IM80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029616.1">
        <property type="nucleotide sequence ID" value="XM_019178460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM80"/>
    <dbReference type="GeneID" id="30195612"/>
    <dbReference type="OrthoDB" id="2588950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="396" mass="43973" checksum="01529EFEE31BD9D2" modified="2017-01-18" version="1">MDKSEVSKIGPDVATKFISLDRTTFDSAINQYFDDNCTQSSRLLTLRGVSRIKKLAQLEAFPPTASYLIEEPHYDVDDETISFAYERIYIPAVPSFLPFSAFLNGYLSNIKFISIWDSRLHLNAAENDDGETKLYVTKVGPTERRGTYWFENILPFFIISPLLSVFLSLAFDITSILSRHPIAEEGPFGAAYSTIAEFIGQEGSVDTEIGYKNHVIWPFRAIGVIIRLIGNSIASSLSFIHSTLHLDNTNPIIQLVSSILGYSLAFLSVLYSNARHFWYTLFGVAEGEAEKWGMAAGEYKALGERYVGQTYGVIDEGLSNAKKVVRKHAQEPSRNLPAAKSPFKDRSWPPQHSSQERGAPSYVTVAKEGIDISPSPQHGHNSREPGAPSYAAATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INU8</accession>
    <name>A0A1E3INU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029784.1">
        <property type="nucleotide sequence ID" value="XM_019178346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INU8"/>
    <dbReference type="GeneID" id="30195492"/>
    <dbReference type="OrthoDB" id="10329243at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="672" mass="73836" checksum="948081209DF0F625" modified="2017-01-18" version="1">MLPLKHTAAARRVFSRALLSKLSSLQLQPRPTARTHLTFTHPSALAFSSSSQAASGHLSQLAKKDDTVLTRLRAGEGQLVDEGYYDPDDKFNGPPVSYDPFRYPAQLQPHLPLAKLRAPSGRPYTPSTTANILCRNHSTTRQLCHETRHGEIFSMETFVIVYESANESDLQSLENGQTFRGRVVFADNRITHLAFDGHLFSVSHDPNGVHGTASLKQVVAVLAETEREMLGIDPKTAADILALHVDERRNGTTHDSSPTPTPSPASSIPSSSDPSSSNDPDELALQHHLESLSNSRKQALAESRSVLDRVRASLDHLVVDYDPEGNKQIFGSDDFKYPAQHHSLPLHTIDPPSSYPYTPNTSARILSPDDTESHEIRNLSKDGKVVTYDGIVRIFEREDDGDFVTQMNNGKTLRARLIFADGRITHLATDGHVFSLSDQGEGLDETVRLERVVGLLGKVEREMLKIEPTLFESIYTQHIAEYTERHSKAKAQAQRRLTADDPPSPSPAPEEALENTHPSSVPTIAEWNLNPHTLINNLPIWAACALQNHPAVFSSPSPAAIGTDEIVERIEKGEGEGLEFFVERAVKEDGLPTRLDPDGKGRWCEWIVRVRSQSEAAQHPEIRAFIATIHDDGLCAKTISIGGTFVNLELLDGGGYVVGEEEEVGVGDLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INY5</accession>
    <name>A0A1E3INY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029545.1">
        <property type="nucleotide sequence ID" value="XM_019178389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INY5"/>
    <dbReference type="GeneID" id="30195535"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.20:FF:000003">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="53"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN89636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="675" mass="73574" checksum="8AD062B8806316F7" modified="2017-01-18" version="1">MPAAVRERSPSGAASGAAKKARSHADQGAQAAINHPSAENVAAYREDYVNAAPFRHAVIGGLLSDDLLEGVVEESKKFGVRGEEGSLPGWGWEHKETDIYRIQQTPDLSSLSPEHLPDETLDALPLLTRLKNALYSQEFRNLVRQVTGCGPLSGIKTDLSCALYTKGSHLLLHDDSISTRLISYILYLPWSPKDASETTDVDLELSKNGKFLKGWSPSWGGGLELFPVEGDEEVGPPSVKRLAKVSATWGQIVFFEVQPGRSYHAVEEVVIDEGRQRFSVSGWFHRPVESEEGFQVFDKEKAQKELSSLAQITSAPSLPFVCYPTPPPVGLKPSDLAFLSNYLSASYLTAPTLERLSGQFVEASEIVLHNFLQPELAAKLKAETEGVDKRDYSPLETLLTPQETGEGDGWVIQGPSSKHRYVALTDSSTSTPIFQSIHNVLFPSDAFRAWLSVVSSLAPTGHRNEARRFRKGLDYTLANGEGREGDARLDVSLGATWWADVPAGSDEEDTLIEHGGWEAYLAAPDDDEDPAVYQSTMAKKPKHEHQQEENKAEGKKTDSASEKQAAPQTNGNGASKADGGPSISIGGQELEFDPNQFSPSDFDSDSEHGEEDDGPLLTQPVAFNKLLLVLRDPGVMKFVKYLGANAPGSRWDVQGEYEVGVLEEEVVGEEKASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQC2</accession>
    <name>A0A1E3IQC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029905.1">
        <property type="nucleotide sequence ID" value="XM_019178186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQC2"/>
    <dbReference type="GeneID" id="30195332"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="301" mass="32127" checksum="4B93C619834CEFAF" modified="2017-01-18" version="1">MVNVFLTGASGFVGSHLTPVLLAAGHNLTALARSDASAYQGITVVRGTLEDTDILEKAAAASDGVIHLGFIHDFTNMPHAIKVELAALEAFGKGLKGTNKPLIMTSGVLLTSSPTPNERTPASTTGRGQAEHLAMSLASSGVRTHIMRLPPTTHGDGDQAFLTFYIQQSKKAGFAGYLGEGENHWPAVHVKDAAELNKLALENPKKSLKGGEILHPTQDAGVPFKDVAAAVSKRLGIPTKSITPEEAGATYSWLGHFISLDFLADSALTREWTGWEPKERALVEEIEKTEWYFAEGTAAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQE8</accession>
    <name>A0A1E3IQE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G1/s-specific cyclin pcl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029921.1">
        <property type="nucleotide sequence ID" value="XM_019178202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQE8"/>
    <dbReference type="GeneID" id="30195348"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="41981" checksum="3EA41AC22EBD383C" modified="2017-01-18" version="1">MFSTSTTAPTTPDFVPQSPCFEDRTHPASMAPCGYHNPALLEFIRTDVSRELVYYLADRTTSVIGQATKDAAPLSPPTTPTKEDSDAAAGLPSLETFVAVVCEQSNVQVSTLLATLVYLERLRHRLPKVNKIGMPCTRHRVFLATLIVSAKYLNDSSPKNKHWCKYAQMFPVSEINLMEKQLLFLLGYDLSVGEQEILDNFEPFLSRYSFFSSPSVASSPELPPTPVTPAHPPRRHSKRHQRTTSLGSRTFVAPPLDRSGSSSSLESDDGPVTPRESPSPVVAHAQRGYACKSQAQAKAQGQRPTAIYEVPLNSSTYLPKSMSIESIRSISQTKVALAVVPSGKENFLQRLLRSDKRRKAPLEEIENQNQSISSLSSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS99</accession>
    <name>A0A1E3IS99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030110.1">
        <property type="nucleotide sequence ID" value="XM_019178071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS99"/>
    <dbReference type="GeneID" id="30195216"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000023">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="315" mass="33896" checksum="651F9011B390005C" modified="2017-01-18" version="1">MSTATATNPDYQTKVFTADGILFDMDGTLTDSIAAVEAAWTAKAEELGLEPEDVIKATHGRRASDNLQDLVPGLRQEHIDREVEKFERSILEFADTPPRRRSSSSSSRSSHSRSMSNSISLSPLTPMTNGTPANGRAAPNTVQPLNLSDLEPKAGASQLEEDVFEDELDEAVDMSVRILPGVSELIKSLPGDKYAVATSGAKTYCHGCLERTGITIPKVCVTADDPRLLRGKPFPDPFLLAASDLGIDPTRAVIFEDSPSGILAAIRAGSTVIAVCTSHKREQISHLGAHFVVDTMDQVGVKVLEDGQLEFTVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU14</accession>
    <name>A0A1E3IU14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030213.1">
        <property type="nucleotide sequence ID" value="XM_019177829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU14"/>
    <dbReference type="GeneID" id="30194963"/>
    <dbReference type="OrthoDB" id="2429551at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="170" mass="18453" checksum="CC6D8D166DAB7CE6" modified="2017-01-18" version="1">MQSIIDTARNAASAVTSSVAPAHHHSEEDHAKSLPADATAGPIKSIDEEGLLVFEDDAVRHGVLVKIRKLALEDERHGLGEVAALNLTDAEGEIKKGIDYYHPKRYFTVTRATGTDYIGEVEIEQGKSIHIRAHKAGAAHTPTFHSIDTRPSDEGGAVFKTGEALVWFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU18</accession>
    <name>A0A1E3IU18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030223.1">
        <property type="nucleotide sequence ID" value="XM_019177839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU18"/>
    <dbReference type="GeneID" id="30194973"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="332" mass="36198" checksum="25F9ECA69E4B62B2" modified="2017-01-18" version="1">MTSFAKASFDVATYLHCRPSYPQRVYSLILAYHSAIRSSPQWGTLLDLGCGPGFVASELAPRFDQTIALDPSATMVSIGLQPVGNDKDGSKPIQYKVGKGENLEAAGIQENSVDLVVAGQAAHWFDHTRVWPQLTRTVRPGGSVVYLGYAEMQFPGHPNVTSIFSNFSSSVIGKYWSQPGRSIVENLLDDVPWPTTPTPVSANIQQTIAKDGLAASQADHGGWDISTAIRIRHSPESPFLMEQSWSLAQLEGYLRTFSAVHEYFAANPEDKAKRIGKGQEDGKGSPSGDVVERVVWELGQELEKAGVLKNGKGKIEVVWPLVLMMIKKESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVV6</accession>
    <name>A0A1E3IVV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030381.1">
        <property type="nucleotide sequence ID" value="XM_019177630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVV6"/>
    <dbReference type="GeneID" id="30194761"/>
    <dbReference type="OrthoDB" id="2592082at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024532">
        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="94423" checksum="51EAB380BAE9FF0E" modified="2017-01-18" version="1">MSSASSTSPIILVTAGGFRFLAVLQTALAPKTTSLFLDLLPYTASLIHVRWSGEGVWIPLGYTSMDISKLPNENHTSHPAPGEFILYPGGISEGEFLLAYGGVTFASKMGQLTGNQFLTIVRGNENLRALGEKTLWDGKQEVRFEIADESTVAAGSNVASLKQTKRRLLASDAASLALHMAEIVVDLQKRLLVVEERVRSLQTGGAPTNDGIGLVANVRVSQEPHLEPDRMVVQHASTSGPSISPAQPSTLHSHNSHAISPSYSSHHRDTDPISSPHHDGQPAVSMSTIQLGAPIATLRSLGALPANGSESMLDPIAQSVLSVLDAQRAIKIFFDHCHSFGPVLDKVSVNDGMRLQHQNPPLFLTICTIGARYWDSGISKAQGPLRERGLHPSFLELTTLLDITISQLILRPTPSDVTLDSIRALLLYAQWMPPSREHLFRATKRSSEGTENQRAPRSRYNDISAWAVLGLAQRYALFLGLDRLSVLPFQDPHTESITPTDMARLRIWHNLITCDCNLMLTSGLPASLDPSSAVRVGRTFSEQQLAQLPEDKRVTALVELVGITHRAMMGREWDLSGRPLDLVSLKKINVEFDDWHNIWVHRLKDTPHQHNALPFTSVRWYRLSLNSASLGPLLSPSPPPSPDPSAHSPFLQPLEISLTAASQILLALSHITPAYIWSLASQDVNTFPVGPFEMNVEAVERLSYAVDYTWISLAFSVVFLVLCRVRGVINDDLSITLAESPIDKLAYPIVHPSSILYRLVYLAHQIFLGLCQTSPIHPAHDYEPIVSNAAALVIPPLDPQQGAMGAGTLAGMEDGQGGDQGNLQGLFDLLSSSGMDWPGYLFGGDGGEQGWSGEVDGVNNEGGNGVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVW8</accession>
    <name>A0A1E3IVW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030329.1">
        <property type="nucleotide sequence ID" value="XM_019177578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVW8"/>
    <dbReference type="GeneID" id="30194709"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13369" checksum="C6DD33F2EA0B793D" modified="2017-01-18" version="1">MFSRLFSTARALPRTTPRARTLYSSSSSLAPRSFTRPGPPPLPAADQAEFEALLKANQTVGTIPKVNQVDAEEELHKDVRKGPKPEFEGEVNPRTGERGGPKQDPFVAGDSDWQFGGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVY1</accession>
    <name>A0A1E3IVY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030200.1">
        <property type="nucleotide sequence ID" value="XM_019177816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVY1"/>
    <dbReference type="GeneID" id="30194950"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30537" checksum="C84E03C97BED52B3" modified="2017-01-18" version="1">MSSHVARKPVRLVLFDVFDTLCTPRLPVHEQYYDEGIKGGISPAHISPLRVRSAFKPAFKKVDASWPLYGKYTTPLLTPEEWWGKIIYETYLEAGAPPAELEKKMDGILPNLLARFESDVGYKLFPETIESLQALKAMGVKTGIVSNADPRIRNICTALTNLSVKTLRSFDILSHITNTPTLSWDVDASKPSLEIYQSACRMAGEELGEGVIMVGDELKADYQGSINAGLEGRLIRRPGEWSDGAQRQAVEDLESVNVITSLTDLVKEVKERNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVY2</accession>
    <name>A0A1E3IVY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">L198_05551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030384.1">
        <property type="nucleotide sequence ID" value="XM_019177633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVY2"/>
    <dbReference type="GeneID" id="30194764"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN92757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="368" mass="40807" checksum="3E0FD5809F306F5E" modified="2017-01-18" version="1">MPPTPCSLCFTARALVKRPKTGQQVCKDCFFEVFETEVHNTIVQEGDGIFQRGERVAIGASGGKDSTVLAHVLSVLNKRYDYGLDLFLLSIDEGITGYRDDSLETVKQNQKEYGLPLKILSYSELYGWTMDRIVDQVGKKNNCTFCGVFRRQALDRGAAQLGVDHIVTGHNADDIAETVLMNIMRGDIARLARCTAVTTQSEDTIKRSKPFKYAYEKEIVMYAYFKKLTYFSTECIYSPDAYRGHARVFLKDLEAVRPSAIVDIIHSGESFMLEQSVQKGMKAMQTCLRCGYISSNDLCKACALLEGLESGLSRSALRQTQDSTSAAPSGHRTIPKYERYSSQHPTGAPVAVGAVEGIEKPLKAIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW5</accession>
    <name>A0A1E3IXW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030517.1">
        <property type="nucleotide sequence ID" value="XM_019177364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW5"/>
    <dbReference type="GeneID" id="30194489"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="38297" checksum="62973AFBF87D70C9" modified="2017-01-18" version="1">MSARALANNARVLARTASNRLYATKASVPPKSIDDSTGALDYKLHRHGKRLPHLVTQHPRYPSAEEAVTNILYNTPPPSAEPFKRHRLNCLVQNEPGVLSRVSGILAGRGFNIDSLVVCQTEIRDLSRMCIVLKGQDGVIEQARRQLEDLVPVWAVLDYTKTSCVERELLLAKVSILGPEFAEAQLLGPLPDASFEHAVENQSHDHPPSFVTAQGEQTDGKYQREEALARSFESGGAPSSGPLYPTRSGQGQDMSASEALIAKNLHLTAIKTLADQFGGRVVDVAENSCIVELTAKSSRVDSFLSLMRPFGVLEAARSGVMVLPRTPVPRYNEEDDIAEKEEIDVSMLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY39</accession>
    <name>A0A1E3IY39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030443.1">
        <property type="nucleotide sequence ID" value="XM_019177692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY39"/>
    <dbReference type="GeneID" id="30194825"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="135" mass="13353" checksum="C6FB3A873F413D97" modified="2017-01-18" version="1">MSFRALQNWRSLIRTDGNSFTLGATVVALNEELTSAHLRRRLSPQSQAGVSWSHRDLSVAPGPSPSPSSAGAPAGGSVGYGGGLSVGLSYMVGHGTGPAVGHGGGLSPASGSSINFGDAPSSPLGDHGVGTGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZV7</accession>
    <name>A0A1E3IZV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05014</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030694.1">
        <property type="nucleotide sequence ID" value="XM_019177113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZV7"/>
    <dbReference type="GeneID" id="30194227"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="206"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN94163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="682" mass="77944" checksum="BBA75D102C73884E" modified="2017-01-18" version="1">MSQPLPADGTGVVTLDPWLEPFSSSLKERYSAYQKQRSVIDKHEGGLAKFSEGYKTMGFQVDAEGGVRYREWAPNALEARLIGDFNQWSHTANPMTKDTFGVFECYVPPISPRVCAIPHDSMVKISMTVPGGTSIDRIPTWLTRVTQDLNISPIYDGRFWNPPQNETYQFKYGHSQQSVDGLKIYEAHVGISSPNMRVTTYKEFETDVLPRIKELGYNCIQMMAIMEHAYYASFGYQVSNFFAASSRYGTPEELKSLIDKAHELGFTVLLDVVHSHACKNILDGINIFDGSDHLYFHEGAKGRHELWDSRLFNYGSHEVLRFLLSNLRFWMDTFMFDGFRFDGVTSMMYKHHGIGTGFSGGYHEYFGEGVDTEAMVYLMLANAMLHEVYPHVITIAEDVSGMPTLCRPVAEGGVGFDYRLSMAIPDMWIKLLKEKSDDEWDIGNICHTLTNRRHQEKSVAYAESHDQALVGDKTLAFWLMDKEMYENMSDFSPLTPVVDRGLALHKMIRFLVHTLGGEAYLNFEGNEFGHPEWMDFPREGNNNSFSHARRQFNLVDDKNLRYKYLYDFDSVMNNLESHFKWLSAPQAYVSLKHEGDKVIVFERAGLLFIFNFHPTQSFVDYRVGVEASGEYKVVLTSDDTRFGGHARVDVNSKYHTTASEWNGRKNWLQVYAPSRTVLVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0A3</accession>
    <name>A0A1E3J0A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05163</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030838.1">
        <property type="nucleotide sequence ID" value="XM_019177257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0A3"/>
    <dbReference type="GeneID" id="30194376"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN94307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="39182" checksum="AA829D4D5F9962D5" modified="2017-01-18" version="1">MPAHPQRSINVAILGATGTVGQRFIELLATHPYFKIHALGASARSAGQPYAKVTKWKLASPIPEAVKNMTVEECKPDAPGFAECGAVFSGLDQDVAGDIEQAFRAAELAVYSNAKNYRRDPLCPLVVPLVNPSHFDIIPHQRASLGLQKGYIITNANCSTTGLVVPLAALEQAFGPLETVLVTTLQAISGSGYPGVSSMDILDNVVPHIGGEEEKIEWETNKILGGLSDDKTSFDLHAPKQINVSAHCTRVPVIDGHTACVSVKFAKSPAPSVAEIEAAFRDFRCEAQELGAPSAPAQAIVLHDAPDRPQPRLDKNLHNGACVSVGRVRECNVFDVKFVCLIDNVRLGAATSSVINAEIAVEKGWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0E8</accession>
    <name>A0A1E3J0E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030888.1">
        <property type="nucleotide sequence ID" value="XM_019177307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0E8"/>
    <dbReference type="GeneID" id="30194429"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="6">
        <location>
            <begin position="138"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="5">
        <location>
            <begin position="483"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="753"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123218" checksum="963F28E4A75BC178" modified="2017-01-18" version="1">MPLLKRKPVYLPPLPSLSAVLQPIPNPAYPVPDPLALPDPTHPPPPPMPNLTQDLLQAYIPGDASEEREQLEKLTGVFRGEFTGGTINIGNKAKKGKAAAEKAQAVYAGMPGVPRQDVNGQVPEQDRMSFVAWKIHDRDTFYIEETGEIFTDYESYAARRAFYDQTIFVDEVTGKSSMGYLDALRSEQKEIRQLHSRFPKQLKRAILQAVQFRVEGKLEVLADKIFERFQNRFFLNERLFVDLENEKYLARIIQVHPPPTDPESESTDPHAQATNLSTEQDELIQQDDPARYLYTVKLVGMDEFEGRPGTAEEIVLRVGADRISRDRVNYSRAILKRFIRDCVERDPAVYSPWTLKPTMAQRYAISTEMPESTRLAIQAYREQQMGKRKREREERLGLSNGEGILMDGEEEDERPKTKKEKKEEEKKMKDDKKKDDDKKSREEEEERKKKKNFKFPNEDYLVDLWEEKEPRLRPVPNKDLPFADQFETFLTSWSFLNVMGTPLNLSPFTIDEFENALNQTDGPTPTLLAEIHACLLNLLVKDRLAGNFTKPLSATGRVMEDDRDYWEGFKGATTELLAPVCKDFVDQWRLSEIPLTKEGRKGWETALVGALWERASLERLPHFLDDILQLTFEPKPAPTRPTWSTAPSSSTGPSSSAALIAIPIPKLTAPSTSRYPSLDPRHKLNIIHFFIELAGQTDRVRSFMEDSIAELTEVRKEQVDVKREWKGVRAEKDGLEPKGEAGAEVGTEVKAEGGEAMEVDEKPNGTNGHLPSVNGEEDRDELEDDVSPDADVDPSRSSSVSPSDPGHHATTSSRRLAMAAAKQSRDVEEAAKKEKVKKEKEEIRLSKEKAIEKKRLETEEEDLALKLKKLDYEFRRHIWSLRAKPLGMDRFGNRVWWLDAQGSAPMLGPDDKVQYGTGRLYLQGVEEVDEEYFLRNANAVLETAGLGTKEGVTKVAVERRRKDEEGEGRLNKGEWGCFDTVEQLKELMGWLNPKGTREKDLLKALTFWRPELEAGITKRRVVLGLEAPAQEEDSTPSEEITVASATARHKRSTRRTAGSVVGDEDGSVEGQGHGKDAYLGWKNRRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0Y1</accession>
    <name>A0A1E3J0Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030846.1">
        <property type="nucleotide sequence ID" value="XM_019177265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0Y1"/>
    <dbReference type="GeneID" id="30194384"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="54"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="209" mass="22570" checksum="2DCF8DE065E5CB18" modified="2017-01-18" version="1">MPPAKGNDTAPPPHWPSDVIYLTKPRLSPRFPPALLPLLAPSSSFAPRPAKHPASVQIKVIMQTGHPANGQFGLFAKQKFKENELVLPYLGVIHVTYTPEDGSESLVTDDHSDSDYDLSLLRISSSDPRNPFPGQHISIGVDAAHAGNGGRFVNDFRGVKPSGPNAEFRVGKGEAGELRMEIWSLKGGIGKGEELLVSYGKGWWGARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D1</accession>
    <name>A0A1E3J1D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prp8 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030913.1">
        <property type="nucleotide sequence ID" value="XM_019176881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D1"/>
    <dbReference type="GeneID" id="30193985"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="40038" checksum="0E634C67819D5165" modified="2017-01-18" version="1">MSVRKEPPSGPGMALSKRARVEDEADEGSMVMTVASSGEGQRKNALIRSVKRTSGLEAPIVSLSGAHGGELTACVFDPSGETLAACSVDRSISLWKTYPPHTNYGILPNVHKTPILDIAYSLDSETLYSGAADGILIWTDLRTGERLSRLSAHYGPLNSLSVTISGGRELVLSGGDDGIARVWDFSLDVKDPVAEFDDGRDCPVTAVAWSSDGNQAFVGGVDNEIKVWDLRTCTILYTLRGHTDTIASLSLSPNGHYLASYSLDSVLIIYDVRPFCQDPTRVYRTLSGAPAGFEQALIRVAWTRHDGGQKIAVGGGDRTVTVWEVETGKIVYKLPGHKGTVTGVAFHPKEPIILTGSKDTNMLLGELDAQDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D5</accession>
    <name>A0A1E3J1D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04841</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030979.1">
        <property type="nucleotide sequence ID" value="XM_019176947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D5"/>
    <dbReference type="GeneID" id="30194054"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="222"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN94700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="328" mass="34984" checksum="1FA5D96EDC1650D1" modified="2017-01-18" version="1">MSARPAAAAAAAAATRLSTLTRHLSTSAPVHREIQKLTVFGAGLMGAGIAQVGAQSGMKVILADVTQKALDNGLTIISKSLSRVAKKKSPDDIEGFTSEILKNISTTTDAAEAVEDADLVVEAIIESIKVKRDLFGFLDGKAKAECIFATNTSSLSVTEIAEACSPERQANFAGLHFFNPVPAMKLVEIIKTSSTSPVTFDALREATIRMGKSPVTCTDTPGFIVNRLLVPYLLEAARMVERGDATAEDIDTAMTLGAGYPMGPFKLLDFVGLDTTSYIAEGWREKAKEADIPEGLVAPIPVIEKLVKEGKLGRKSGEGFYKYDQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1E1</accession>
    <name>A0A1E3J1E1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030962.1">
        <property type="nucleotide sequence ID" value="XM_019176930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1E1"/>
    <dbReference type="GeneID" id="30194037"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="36912" checksum="373C10E5223D9218" modified="2017-01-18" version="1">MSQPFASPLSTLDPLPPEIIQVIFGHLIILSQGSKALASRLSRTSKHFLSLISPQLYRRLSLCASNAAQFFYGLEGLESGELRHFDGSFGRDGSGLEGKSLAERRLIWIGLVREVAIEDAEALKACYKAVKAIVGPKPRRFHGRTLFFWGRAKGEEATLTLSSHLCETFGSANPNNAPYVFPILYALAQSCSLVIDLPHELERMLESSIPAFHAICRGLSPCVKSVTINNYRATPFETKTIYASGFFSFFDSSLSGGRLSTVRLALAPGIEQLQEMLHIARLAANAALPEVTIAFDNYHLQPGETKVQIQQAVEEAHERAEEESCIVSLGVAFRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1L3</accession>
    <name>A0A1E3J1L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031036.1">
        <property type="nucleotide sequence ID" value="XM_019177004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1L3"/>
    <dbReference type="GeneID" id="30194114"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="18142" checksum="0A2127A51267EC74" modified="2017-01-18" version="1">MSNLAQARLHEERKQWRKDHPFGFYAKPLKNADGTLNIMSWEVGIPGRAGTDWEGGVYVVKMVFPDDFPTKPPKCKFDPPLYHPNVYPSGTICLSILDEEKSWKPSITIKQIVLGVQDLLNNANVNDPAQVEAYQMFKNDRPTYDKRIRAQAIERRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Q1</accession>
    <name>A0A1E3J1Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031089.1">
        <property type="nucleotide sequence ID" value="XM_019177057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Q1"/>
    <dbReference type="GeneID" id="30194170"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="316"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="491" mass="53838" checksum="CE590A079C4B6AE4" modified="2017-01-18" version="1">MRWPRQYKTLPLVAAFALLLLSVLGYLTQSMRLCLPFSLSKLSTTAHNNLSCQAIKPFANMSDTRIQTEDVQEGRLAGFLISQRDLFLQDLREGKGKGWTVVMGNEAGDLDSLASSIAFSQLSSTLLASRVIPLILTPPKFMPLRPENLLALRNASLPLYSLLHTNQLPIATSELAGQGVKFALVDHNRLLPQFGDGQVESVIDHHEDEGVHTDASIREITFPTGSCTSLVTKHFREQWEASLSRGSPIPSELATLLLSGILIDTGGLKPGRKATPIDYEAAAFLYPISTLPQIGSNFSVSAVSAEAVPAPLSGLAETLSETKNDVSTLSTYELLMRDYKEYTWPTQAAAYPSLKVGLSTVPLGLKPWIAKAPEGWESLMEGVRVWMQERTLDLEGILTTYSSEKKGKHKRQLALIARAGGGFHTNEHAEQVFASLVKGLEASEELVLQEWNQEKAVKREVVGGEEVWVKVWVQGNAKATRKQVAPLLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1T7</accession>
    <name>A0A1E3J1T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031071.1">
        <property type="nucleotide sequence ID" value="XM_019177039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1T7"/>
    <dbReference type="GeneID" id="30194149"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="47460" checksum="48D1927A3086E96E" modified="2017-01-18" version="1">MSPSPSPAPPAALHPHLRDHLTESHTSSPAPSGDVDEDVRMEGEDDELEAEDKAAEELPPKAEPVAEVKAEDEKKEEKEKCLWGDCEDEFADKQVFYGHVKDHINASKEFACEWRTCARVGQKQGRSLLLTHIRGHTGEKPYTCNIADCAKSFARTDALNKHKRTVHADLLNPNGAPPKPAKEPKEPKEPKAKGPGRGKGRKSLAAAGSASSSNALPDATSANYRARTPPTLIPTQSIPPGFAAPDSDLCYDSELYDVIPRLRARRRFLPESEEELYALMVAEKKFPKHRMFPDYSPEGDGGRDRGEGSGQEVIGKRRKTVLDDLVPNPLDEPVIPPRPDANPHASAELDDIFPLTSTLVQQIDDAEDPESGPIQVLSRCRWQARYVLAKARLMLLDEENGMRQGYLRDIMEIQMRAGVAGQIIEEKPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2W8</accession>
    <name>A0A1E3J2W8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031172.1">
        <property type="nucleotide sequence ID" value="XM_019176697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2W8"/>
    <dbReference type="GeneID" id="30193792"/>
    <dbReference type="OrthoDB" id="2571494at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="196" mass="21081" checksum="413DE80DA8B457F6" modified="2017-01-18" version="1">MPFTPRLQRDRSHSHSSSLSISRSPNVLSAANFGGPPVSPHELDGPSFFEHRHAPRGSALGRTVSASGGDRLSAIQSVEDLTSAKPSTAEALIDPGAKTPSRLEAYTPDTYDTYEERLSAPLLKPQVHFDAPVSEAGEDETMDLDGVERLDGPAFEYTGPFQPPDSRELTLYMLSFGGVVILAVAAGLTTIFDWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3D6</accession>
    <name>A0A1E3J3D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Periodic tryptophan protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031337.1">
        <property type="nucleotide sequence ID" value="XM_019176862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3D6"/>
    <dbReference type="GeneID" id="30193966"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="9">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="754"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="884" mass="97497" checksum="6F96172F6FC3C90D" modified="2017-01-18" version="1">MKSNFQFQNLCGTVYRQGNVAFTPDGNSVLSPVGNRVSVFDLVNNKSRTLGFENRKNIATIALSPDGNVLISVDEDGRALFINFRKGTVLHHINFKRHVNHVSFSPDGKYIAITHGHKVQIWNTPSHLVREFAPFTLHREYTGHHDDVVSVCWSKTSRYFVSTSRDMTARLYTINPLEGFTPKQFAGHRDMVIGAYFSLDEKTIYTISRDGAVFVWKAKKGVSDEDSDVELDILDAPTTSTSAANLALEHTVAYSRWGVHSRHFFNQPGTKTVCATFHPKTSLLIVGFSSGVFGLWEMPDFSPVHTLSISNEKISSVAVSPSGEWLAFGASKLGQLLVWEWQSESYVLKQQGHYYDMNTLAFSPDAQNIATGGEDGKVKLWNATSGYCFVTFPEHTAAVSTVEFSKQGQVLFSASLDGTVRAYDLVRYRNFRTFTSPSPVQFSALAVDPSGDVVCAGSQDSFEIYMWSVQTGKLLDILTGHTAPISNLAFSPSGNQLASSSWDRSVRLWSVFGRSRATEPIELSGEATALAFRPDGKEICVATLNGELSFIDIEEGEIKSVIEGRRDISGGRKIDDRLTAGNNAASKYFNSVTYTADGACVLAGGSSKYVVIYDRAEGVMIKKFQISENLSLDGTQEMLDSRKMTEAGAMDTFDRQGEEEDLEDRLDSTLPGASKGDLSKRRYRRDARTNCVRFSATGRSWAAASTEGLLIYSLDESTTFDPFDLSLDLTPESTLQTAAQGDYLIALIMALRLNEKPLIQRVYEAVPPSSIRLLARQLPEVYVAQFVKFVSDHIEATPHVEFDLMWTAAMLTSHGRYLRERKGEMAATLRGLVKGLNGLEASVAKISDDNTFSLDYILSQVGKSEQANGFEGEGSAFILDVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3E7</accession>
    <name>A0A1E3J3E7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04769</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031353.1">
        <property type="nucleotide sequence ID" value="XM_019176878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3E7"/>
    <dbReference type="GeneID" id="30193982"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="552" mass="59488" checksum="CC8ED69F1172F9C1" modified="2017-01-18" version="1">MGGAVFLGCWLMGGSWLVGVLGVVSHLSHWWFLEFVEGPHMQKLYGNRLRKDGGLTKTLKSNLPNSTAVRQAVSKHPRVSRVVSEVNRGIEKVEERVRGGVEDFLDHARPMLDGVVDDARGLLQQSRERMIITRVAKPKDLTSFDPSSYSLQIPTSSSSPTPYPAFHVGQPIPISWNAPSNHSSKDWIGIYRLGSCKSEIVTKISSVGKWVGVYEEEWEGNEHVTPESEGKKADAGMVVLKGKQLPWQPGQYEIRYHHDGKHNVMSRLAPIELYVDKPRASRSSRLSSPRRSSASLSSSPSKSVKTAEIKEEVGVKEVRETMMKLVCLALEGEEELVPKAAKGKAVMRLASVPTAASQVSPGKALNKPTLSYTPELDEGDEGEDGVEADAEVEDQGSLLGSGVSGGEKRAGKAGKADKKGKGKKGGVGIEDEVTPTKDTFSPSNLASADNPHALDHLASLADRSAVPQRSILGLADDDSTRDPGIDRSVDSDSDPEPEGDDFTIMTETQAKRIATLAKYAFGVELDADVVVAEANVGALARRVVGAWSLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3Z4</accession>
    <name>A0A1E3J3Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031115.1">
        <property type="nucleotide sequence ID" value="XM_019177083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3Z4"/>
    <dbReference type="GeneID" id="30194197"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN94836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="227" mass="24645" checksum="7ACD389C05C76E88" modified="2017-01-18" version="1">MLATVSSLTCTAPRATPALRSAAMASLRTKHTLPDLPYAYDALEPSVSAEIMNLHHTKHHQTYVNGLNAAEESLSKLTSEGDVKGAIALQPALKFNGGGHINHSLFWKNLAPHGSAEAKFPSSGALYDQVQADFGSFDNLKKELSTKSAGVQGSGWGWLGFNKGTKKLEVVTTANQDPLLTHVPIIGIDVWEHAFYLQYKNVKADYLSAIWDVINYKEAEARLKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4A3</accession>
    <name>A0A1E3J4A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD finger-like domain-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031365.1">
        <property type="nucleotide sequence ID" value="XM_019176437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4A3"/>
    <dbReference type="GeneID" id="30193531"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="67" mass="7306" checksum="69282FCF8944131B" modified="2017-01-18" version="1">MSKHHPDLLMCRRQPGIAIGRMCEKCDGKCPICDSYVRPMTLVRICDECSFGTTAGKCIVCSSPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4B9</accession>
    <name>A0A1E3J4B9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031357.1">
        <property type="nucleotide sequence ID" value="XM_019176429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4B9"/>
    <dbReference type="GeneID" id="30193523"/>
    <dbReference type="OrthoDB" id="2369050at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20358" checksum="A200F0FEC66ABB65" modified="2017-01-18" version="1">MDVYVGNTIYRDSPFVVMPLGPANRMILGLPFHLQHRLLAGASGLEALLEEGRATRRREQDGEVVVGSGLARISEVSLELASELVTRRKELTAQLLTDFADILPPQLTDVASYPKPAPSVSQVRHHINVLPNTKPVARPYYRLPLVFGSAFKAEIDKHVDAGRLRTSSSPWAAPAFLIQKENGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Y3</accession>
    <name>A0A1E3J4Y3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031584.1">
        <property type="nucleotide sequence ID" value="XM_019176656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Y3"/>
    <dbReference type="GeneID" id="30193751"/>
    <dbReference type="OrthoDB" id="5364416at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="179" mass="20391" checksum="2CCC9405409591D7" modified="2017-01-18" version="1">MPGPIHPQSPLILTLTLDKASHKFLTDLRSKYFPSSRNFLTAHVTLFHAIPAHRFGELEERLDRICAEQQGWDVFIGEPVKMGNRGVMVNLRERPSNTTPRIHQQLLGFLKEGVNNEQDRLTNQDLQPMKRPHVTVLNKASDEEQVDTCLSEVTKLFEDMKQEGQATGQYKGRAVGFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6P2</accession>
    <name>A0A1E3J6P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04384</name>
        <name evidence="2" type="ORF">L198_06570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029326.1">
        <property type="nucleotide sequence ID" value="XM_019178625.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031431.1">
        <property type="nucleotide sequence ID" value="XM_019176503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6P2"/>
    <dbReference type="GeneID" id="30193597"/>
    <dbReference type="GeneID" id="30195782"/>
    <dbReference type="OrthoDB" id="2578283at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25631" checksum="A1A43363586D621B" modified="2017-01-18" version="1">MTPTTSPKSPGSPPHEQTSYGVKRKFDDEEEDSPPPTPRPDKRARESPNAQLPTPPNSSPSRPLAPEPDKPLPSLPTEIVNYIIGLADSGTLRTIAGVSKTFRSESRRARKRQLSASRGFGADEHIEFRVYDAECPISANPSEVVTTGRSQFGVMSSVVLGEGRSKAPFKVEGQLGTYKLSWNGKSYWATRALNQEEDDAFGSQLLQLGFLGRLGALFKLFREEVKSEIAALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7E8</accession>
    <name>A0A1E3J7E8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031526.1">
        <property type="nucleotide sequence ID" value="XM_019176598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7E8"/>
    <dbReference type="GeneID" id="30193693"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130172" evidence="2">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="447"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="67697" checksum="0E20D2BEB482986A" modified="2017-01-18" version="1">MLLNSLTLAGLVVLALPARAADRANTFQYVGLSGVSAQQLFLGTLNKVYIVDKTENNNATVNSHPAWATEYDLTTNDFRTMDVLSNSFCAGGSQLGNGTWLNVGGNQAVTYNGNSQSPYKDWDGGKAVRLLDACDDESCDWIDDPGLYMTSRRWYPTLETLEDGTIIIMGGCEWGGYVNYADNQNNPTVEYFPKKGTPFTLNFLLNTMPVNLFPLVWLLPSGNLFVQAEYQAEIFDYKNNIEYPISNIPDCVRVYPASAGTAVFPMTPENNWTSTIIFCGGTYLESDQWTTDWNIAEYANNKSCVHISPDVDLTWYQNDPLDTGRSMGNFINLPDGRLFYVNGAETGTAGYGTQDWCVGESYADNPLYQSWYFDPKQPSGSRWSKAGVSSIPRMYHSTASLLPDGTVIISGGNPNADCNAEYNTSYTYFTQYQVEIFYPDYADRNKPDPSGMPSQLTYGGDYFNVTLSATDLFNNPININNTRAVVMRTGFSTHTMNMGMRHVELETSFTSTDDGGGILHVAQMPPNPAILAPGNALFFIVVDGVPSNASWVMVGDGIVGDPTVKDRSVLPRSQISAQIMAQYGYGNSYAKASTSGGLARLGEGMGVLGAALLACMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7H7</accession>
    <name>A0A1E3J7H7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031556.1">
        <property type="nucleotide sequence ID" value="XM_019176628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7H7"/>
    <dbReference type="GeneID" id="30193723"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000066">
        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130173" description="CMP/dCMP-type deaminase domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="262" mass="28502" checksum="0142D11B90136AE6" modified="2017-01-18" version="1">MLLPSLLPLFALLPSFTPTPTLVGAYDTAIHPEFQQGLAINDVPSHRRLHWMRVANEAVYADGHPCPQAPFGSAVVNTTGDELVCVISNRVGVTGNPAMHGEISAITHCTDVLTKKGWTPQEILGAWKEFSLYTNGEPCPMCASAIRWAGFKEVIYGSSIRTIAEHGRNQIYIPSSEVWEKSYSLGHATLMLGNVLTNETDVFFAHQFNESAPCPVGCERQPVPGKRVQACTPVNNWEEVIAKAGVGLALGQSKVQGRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J985</accession>
    <name>A0A1E3J985_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031837.1">
        <property type="nucleotide sequence ID" value="XM_019175924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J985"/>
    <dbReference type="GeneID" id="30193011"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN97235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="135" mass="15592" checksum="9055DF88A98CA38C" modified="2017-01-18" version="1">MTSELSHLGQFDYDIRIYSLTQTSANTSIPRSTTPDTPHLPFVLQQCLRSLNKKGEQTTNEALVIARVKFKPLVFSSGGMTSKGTVEELRQWGRRLERRMLRLKERIGLELLRCYGYVMPMHNNTKHQKGYIDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J991</accession>
    <name>A0A1E3J991_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032014.1">
        <property type="nucleotide sequence ID" value="XM_019176101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J991"/>
    <dbReference type="GeneID" id="30193189"/>
    <dbReference type="OrthoDB" id="2563601at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130267" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="21548" checksum="7AE20A2AC20B9D88" modified="2017-01-18" version="1">MVQTRLWQLTLIFILYTGALVLAAPTLKKPLPKRDFIDSPKNPIVVTPFQPRHHRFKRPTHAYPLAHSPTTSSFPPSPIEPDLTAASPHVKAEGWLVQILRIFSAWHPFPENQIAEGSSHKRIRRWRLVGSKRPMRDLVLVNDVDGSGRRLVDRGGDLIIQEPQLKGFQWRGAEELDDETDEPYYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9G8</accession>
    <name>A0A1E3J9G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031917.1">
        <property type="nucleotide sequence ID" value="XM_019176004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9G8"/>
    <dbReference type="GeneID" id="30193091"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19413" checksum="6ED339EF2D3C4835" modified="2017-01-18" version="1">MFSGCHAGGLHLRGFLGVAYLRWMDPSFALFIKGIGLVIFSTLRATIPGKGGIACLFMIYTSSSRKVCYPVIFSSLWGCPVVPSIQGAVSDAISTWRSFIIPLTGFVPLLCYGGVMWVINSKKYHGRLTIWTSQTNVNVEESTGQYTPEVGARDDIEKSAFLEHNEKPVVESRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBQ0</accession>
    <name>A0A1E3JBQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032141.1">
        <property type="nucleotide sequence ID" value="XM_019175651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBQ0"/>
    <dbReference type="GeneID" id="30192735"/>
    <dbReference type="OrthoDB" id="10456957at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17871" checksum="2CAB02CE3653F577" modified="2017-01-18" version="1">MSTEEVKTAAAPAAAPTAAPDAAAPAAAPAAEKIELAAPIETAKEPETGDKRKAEEPVVSEAEEKKTKVDDVKGKGKSTDKPPVETTAPVDEEEEDLDTLIQPGRRNRKPVNYADPEAWKKAELDPNAPEDDDDKEDAVPEESGDEDEDDDAPEAPATAEVDDEDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBX6</accession>
    <name>A0A1E3JBX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032245.1">
        <property type="nucleotide sequence ID" value="XM_019175755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBX6"/>
    <dbReference type="GeneID" id="30192840"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="800" mass="86347" checksum="5177EE12DB3E1FB5" modified="2017-01-18" version="1">MPVVPQYISVGSNRSSSCSACTSDGLLFFGAGKLIALWDSTSPRGVHVTLPGHKGQVTTVKLLPDGRLVSGDSIGDVRIWAESQGQWKSVMSWQAHRGASVSAIGAMSAKGHLDGVLVTGGSDGLVRIWRVGGSKPEEVQKIDLKGRLALDLDLAYLPGTQAPILAIGCTDRRIQIWTYASNIFTRSLSLEGHEDWVRCLQFTPYPSSSSTNDLLLASGSQDNFIRLWRVSPIAPQEAAAPDMDEGLEMLDEFEKRLAGEGGGNTQISTKAHILGVQDGDDAIKFNITLEALLVGHESGLTNVHWSTAPTTLSTTPLLLSTAADNSLIVWQPSSASISTDGIWVPTNRFGAIGGRGLAFYGAIWGQDGKSVLAGGWNGGWEKWVLGEDGSSWEVKRGLTGHHGDVQSIAWDPRGEYLLSVSSDQSSRIHAQCDLPSFPQPVWAEIARPQIHGYDMTDATFISPFRFASTADEKVTRVFDAPEGFVESLRTLGVSKRKRDEELRPKGATVPPLGLSNRALQKAPVDGDKVEKQGQNEAIVSISHTLTTLPTEEELATSTLWPEVEKVYGHGYELVAVASSHSGRFIATACKATNEEHAVIRVVSTSKWESVGHALQGHSLTITRLGFSGDDERILSCSRDRGWRVWQRRSANEEDGYALLAGEEKAHARMVLDCCWAGERSDMFATASRDKTVKIWIPSSPDSSQWVSSASVKLTEATTAVAVVAKPSSDGYLMAIGTESGSISVHSVNAEGSEVAHLETLDHRDTHVSTVNRLAWRDIDGALSLASCSDDRSVRVFSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC39</accession>
    <name>A0A1E3JC39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032281.1">
        <property type="nucleotide sequence ID" value="XM_019175791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC39"/>
    <dbReference type="GeneID" id="30192876"/>
    <dbReference type="OrthoDB" id="2563954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="568" mass="60716" checksum="C789B88830952F43" modified="2017-01-18" version="1">MPSDDTMGGLDALVAAASSVREGKRGKAAGNAKDAPAANIAMDMIDPSLHNENGDKLNPSALKSLLNAPHIRSYLAEYHANNPSSLSAQLFAGGAPTAQPAPGPPTPAQVTRYGRISRPSGLPPTPGRSSETGGNDTQLQLIKDALENVQGAGSEGQASDTQYEGLANLASSQAEGRFWKTGENSAAGAAWDGAETLQAALKDSDGQNKRPRVRLEPSEDKEEGNEPELPQWPLPPTGKGGRKAMPRDELLARRRARNKVAAQESRKRKKMHYGTLEEQLQEKDNVYAELQTHCRNLERELELTKRVLTNSGIPHPHFVPEVHAPLPPRSRTSTEEPDAARPRSGRSAGSSAPTPGVHAEDYSSLASLSMVQSAPTPAPNPVSAPPAAPAELAFSDLFNIDEDENDADFVPASSPGARESDSEDSEEEEVEESRPRKKARGAANSSSAKGKGKAKAKQSQAVNEEEIDELATPPPETPASGDEDDDEEENLFLPIEDVPIPPRDHATEEQTRVMEQAMKELGVETPEELMETVRKLVETTDHGGVTPAQVGTLTRLLALGQAQGLNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC40</accession>
    <name>A0A1E3JC40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032312.1">
        <property type="nucleotide sequence ID" value="XM_019175822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC40"/>
    <dbReference type="GeneID" id="30192908"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN98450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="32314" checksum="1F7E79E35DB77A8A" modified="2017-01-18" version="1">MAEDQTFDSLLDLLRRLPPTKVEDNVNVLCDLAPEYADDLLGNVDQPLKVLSDDGEGREFLGCDYNRDGDSFRSPWSNKYLPVDTQGPVPSPRLRQLEVALNSAFDTYREMYFEGGVSSVYLWDLDDEPQGKEMAFAGVVLVKKTLSPQANVPTAPSGSWDSLHVFECQERGRSAKYKLTSTVMLLMDTKTLAKAEEKGLENAEGKGNVALSGSMTRQAEIDYPLPTPQSHVANVGRMVEDMELKMRNLLSAVYFGKTKDVVNELRSQAGLDAKSKEDLLRAELAGKLGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCE7</accession>
    <name>A0A1E3JCE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osomolarity two-component system, response regulator SSK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032405.1">
        <property type="nucleotide sequence ID" value="XM_019175915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193002"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="949"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1314" mass="141391" checksum="2B4BD588B9E24A22" modified="2017-01-18" version="1">MSAPPSPRELPSPPPISAASSSTSSQPIFDWPPANADHVAPPDPFDTFDPPSSSSEDGFMSAANPAQSHHRPATEPSEHDERPLHSDSTAGPSLSAPTFSNPPPYSRTISSPLPSRIELLRHPHSGTPDLRHTQAQPRPSPVHSISEELADTLQSTIQTLLHLLPPHMLDNAKEQYSGCAVQIPATSLSALLTSMKGLNFLSAQAETLFNPSAIEEHQTLQKQDFDVGELLQSVADMLSGDACKKKIDFVLFHGDVGLKHVSVNGDSGGLAYALGHIIRQLLAVASVNDTIELGLQIIPQSSSLPTSVNLSLSSSDVDWGGRRNSSVSDPATVVSEVDDQADGPLLCIFEIVHNIHQPAPGSASATPKAELNPFTRLAEDSAAAKPNLDTIFCQRLLQRQNALLRSDVQPSSPLGSGMPRRAYELSVLLPRGKPIIEPPPLSAEEQAVRQPFSSLELAREPTLLELQEFTESLRGRRVAVHANLSSVFARHLTSYLAAWGMDISHMSIGDGDEGGDREKWFAATRSDSGYGGSVGTTPTGEPYHTTPNAAGQRAHFVIIDDDVVVLKKELSRLCSDLARPANKSRFPERPTMVSRTKSTPSIRHLGQHPVTKQARVVLIHFTSLTNYNQVRDAIASLVGSPVTTISGVCLQPEVMVIPKPVGPRRFLTALRTAVVQPTVDPFFSPIATSPRSPGGEYFGGHIPIPKERQTGFFDSVAEELNEEPSKENLSSQKARSPLGEVPPSAAQLVQTDHGLHLSLPTPGEIVATPAQEYFSKTPARNTAASGVVIQSPDGRPYGMFFEPPNKSERRGSTHRVPSETQRRISANRRASTGDELSVAPNSAPPIPQRSSTISTAATEERRNSIGSGNASDRPTHSRKNSRRTNNLPATQQPVVAVGRANSRGRVDTVTNPAVSSKPGTPPIDSPIVHSPFEVSKESILPKLDQEKVVPEKTEQAERPEKVDKPKRALSAKAELQASIATSTTAIKASAKADVIVPPINVLIVEDNPINQNILSKFLRKKKINNQSAKDGAEAVEKWRTGGFHLILMDIQLPVMDGIAATKEIRRLERHNNIGVFPSTPAGEHSRGPSVGSAYSPSPATPFRSSVIIVALTASSLQSDRVAALAAGCNDFLTKPVSLKWLDKKIVEWGCMQALIDFDGWRRWKSSDASETRQGFSVGPQQAAKSLASRLRIERKNSRPLIPSAPKVSVQVPTPSPALTPSLSTTTSHTPKPRLPPLATADPAPFPSPKELGQSLDQVFEQADQRLEKAREETGIKGSGERDQEASASEESTLIVRGVPKAAAEKPLPPLPNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF62</accession>
    <name>A0A1E3JF62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032403.1">
        <property type="nucleotide sequence ID" value="XM_019175913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF62"/>
    <dbReference type="GeneID" id="30193000"/>
    <dbReference type="OrthoDB" id="2597002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="44410" checksum="8A2741A3DDAAAEE8" modified="2017-01-18" version="1">MASPVKEPGRSLLTSLRPPAALPAPATAPDAAHHLHPHDAVHPQPSGSILRRESSSFPSDHGTDGSLDGVSEGHPHSHDLNIPSPSGQPRHSALRFQVAQAQSPRSSSSYTRPSPRELLDNDRVIKSDSESGDGYIEDEDSSSSRSGDSDPVSRSVFGRLAQIQRRHSVSEREEGKSDSSLDSASWSPLKQTRLPGESQPGKPGNTSTRSPDPDPDSEKSRSSSRQRPRGRLSDAGPRGGRAGSPMPEPQSAESDDGGLDELASRNPPTLSGAGWRSDDPALYEPRKRADKLQSGRLYNRRFSFGLARPFLHGSEQVPTTEDLFEGRSDGFTSFFRRASEHIPGLSPRPASDHDPLSPSGTNHSSPVPPILDDTPALARGIQANEYSDTRGGLAHRLEEALSSPSHSDSPHRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFI5</accession>
    <name>A0A1E3JFI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="10" type="ORF">L198_03463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032696.1">
        <property type="nucleotide sequence ID" value="XM_019175593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFI5"/>
    <dbReference type="GeneID" id="30192676"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130314" description="Eukaryotic translation initiation factor 3 subunit I" evidence="9">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="41130" checksum="968D1E1F08088624" modified="2017-01-18" version="1">MPLVALVVAILTILTQLALFYKLGCQKTTKMKPIILQGHERSLNQIAFNAEGDILFSASKDNVVNAWYTSNGERLGTYGGIKGGVGHNGAVWTVAVDSQTKFLLTGGADNVMKLWEVETGECLFTWEFLTAVKRVAWSEDDSQFLSVTEERSRQPSVIRIFKFNRDQPTSQPTEPTCEMRLTGSRATVAVWAPLSDHIVTGHESGKIAKYDVKTGEEVQAVETEHSGLITDIQLSPDGTYFISSSKDKTARLWDLKTLEVMKVFPTETPVNSAVITPGRPYIILGGGQDAMNVTTTSQRAGKFESRFFHKLFEEEVGRVKGHFGPINTLAVHPEGRAYASGSEDGFVRVHWFDDSYFRSRPFGDLEPEVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIC3</accession>
    <name>A0A1E3JIC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032777.1">
        <property type="nucleotide sequence ID" value="XM_019175045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIC3"/>
    <dbReference type="GeneID" id="30192118"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="591"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="779" mass="85572" checksum="C92B64F5BCB3D4A3" modified="2017-01-18" version="1">MEDTTSPRAKHRAEHLARDAAAASHASYYAHPALHLHTYLGGDKQPAVVDREGQLVGALNDPAQPIAQGPEGSAPPTGAPTKPGAGVHNIPGVNANTEADRKTGIEGTKEEEGGKQDAGAPSGVDKGALEIGGEAGGTKTSPGPTAEQVQQHRAQVQQQNGNHLDVPNGRPGLERHRSVQGRMNPHLQMMCGPLISYYTVKDNIWQGAAMVVIRNEGSVLNPPPALSLAFHPYTPPSDGQPTLHEPEVQLLPPATIPSQNIFTYNSSEGAMSFHRFIIEVPLQRIQTTVRYSLNGGAAMDFVVPALGQNLRWAAHSCNVGFSSGVNPDDFKGSYPSGYDPVWEDMLLKHQEKAFHCMVGGGDQIYCDAITREPELQSWINAPDRKSKLASPLTDEIRLAVDRFYFNHYCKIFRSNAFGRANSTIPMVNMLDDHDLIDGFGTYDDETQASSLMSHVGSRGYFWFLLFQLFVHDGFDGVDHTPGTHIVKSLVLGDKNGPWIPHPTHSLLVYLGPKVGMLALDCRAERKLSEIVRPETYAKNFAEARKRFVGIEQLVLLLGVPIAYPRMSFLEHFLELKWNPVNILARHNAMGLGGMVNKFNQASELLDDLNDHWCANTHKKERNWLVLECQKIAQETHARVTFLSGDVHLAAVGCLYTKGSKKGQGLMEPEKDWRYMLNVVTSAIVNTPPPGGAAKMVAMLGGHTHRTLHKHDTDEHMFPLFKTDTDGSALSKQFTLARRNYTIVEYQQGDGSLSFDIRVEKSQGAGETVGYEVKAPAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIE0</accession>
    <name>A0A1E3JIE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032846.1">
        <property type="nucleotide sequence ID" value="XM_019175114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIE0"/>
    <dbReference type="GeneID" id="30192189"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000012">
        <property type="entry name" value="Cation-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="770" mass="87066" checksum="E4C14727CB5A07AD" modified="2017-01-18" version="1">MSAVLGREEEAKTFKYESDITRLRSLVIHSLYSHKDVFLRELISNANDALEKLRLTALTDRSVMSSGEANITIEVVLDEDGQGKTGQIIIRDTGIGMTDEEMSRNLGTIARSGTNEFLKKADEGKVDSNLIGQFGESSCLGFYSCFLVSPTVRVSSLPPPTKENPRPTQYTFVSEASGDSFQIFTDPRGNTLGRGTEIILTIGEDEKEWLSVAKLKGLIEKHSSFSTTFPIYVKERKVSQVPIESDDDFEDEDDEAKQEKFENVVEENWVHVNDRPPIWMREPKEVDDEEYKAFYKAVSKDPFAETLGWSHFKADTGDGVSFRSIMYIPSSLPKDFWQKITSGIDNVRLMVKRVFITDNLGEEFMPRWLSFLKVTVDADDLPLNVSRETLQHTRFLSQLQRILIRKAIDLFTKLANDQPKAFEEVSKLYGNALRLGVMESKKDHVKLAKLLRFESTRSNYTSLEEYVENRKEGQTQIYYMAGVGERAEDLRRSPFVEKLIARGYEVLLLNLPSDEPMMGALNNFMGMKTQDVSKKGLKYGDEDEDEAEKKELEAQKITFGVLISWLKKELKGQVNDVVLTNRLVTSPCTIVVDHMGWSANMQRIMAAQADAQEDPMYQAMKNLPKVLEINPKSPLVEGLLDRVLELTGSGEDDEEGTLKESEEEEELREVVRVLLDTTLVRSGFSVADPTSYFDRVESLLRRSLNIDLNAETPANVRPAPPTAMGPLDEEGVPHEDSFENLFPGQNVMEGSEWLDWADMKKQADGGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY1</accession>
    <name>A0A1E3JIY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033033.1">
        <property type="nucleotide sequence ID" value="XM_019175300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192381"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03369">
        <property type="entry name" value="ABCC_NFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1293"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="354"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="722"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1381"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO00841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1656" mass="182224" checksum="5AACD9FD0B22F840" modified="2017-01-18" version="1">MYHALLTLAATAAIPLTTLASLTIYLATNPASPITTLFAPQPIALPVHNGEALDGLLDQKDPFDIHNPTVCEDGTPVEPERFWAAMWRRKLAVLVLYLLPLACNICLLAFSIVSDAHDDESRQRSIALSVLLLASQVITLLLSYWHLAQRDVASHWATTIHLAVDISTQFLVLAFLSLLPSSPLPSDPVVPTAFNALAFSITESPVGLLKTLLPILYLPSLVAILSVRRGPPLYLPLDAIYPSKIIASVPEDASALDPTQANVSPEVQANVPEWLLFGYATGVIRKGYVAESMDVWDLPILPATLRKSIPCALVQFQRMKKAYGHRKERLGRMEGFNLLLVLAKVNIGLLVAQTVLATATAFGYYLPHYLLKLFINFLENDPTRSEPAWGWLLCFGLFTSNALIFIASGVTWSICTTYLQGKIRLQLNTMLFKKTLLKKDIAGKGSNKDQVGGVADEAAKDKQRSAQGEKEDGDEDEEGVSSKTQIMSLFTIDVDRVTEFVFHLFAVIDAPLEIVVASIFVFKLLGISAMYGLLTAVLSLPLNHFASKIVVRAQENLMKNRDQRTALMNEILQGIRMLKFMAWERSFETRVQSIRTNELSWQARNYQIEVAFNCIWALTPVMVTVVSFLHYTLVRGQTLTPSVAFTSVAVFAELRYALNAIPETFIQALQGFVSCRRIEKYLSLAEVPTPQDNDGQGDIILSSATFTWPQDDFAASAEPDTPPPHSAALTPKDAFTLADLNLQFPNGKLTLICGRLGSGKTLLLSGLLGEADLVTGNMVCPRSSPDAMQDAAGWTGTDNWIVPNLVGYVPQQAWLQNQSIKENIIFSSPWDAERYQQVLEACSLTMDLEILEDGDETEIGEKGLNLSGGQKARVSLARAIYSRAGVLLLDDVLSAVDAHTAHAIMHNCLKGPIVEGRTIVVVSHHVALVSPGAAYIVALENGDVKFSGSRDEFVATGLLEELEDEDSQAKFTEAEQQERSAVEEAALKPAHKSVVSLSGTGNPSEPTSETSSLAPEDEVTLVGSAQETKSKPPRKLIEDEKRARGRIAADVWKTYFKALGGPWWWAFFLLSLAMAMVVPVCEKGWLEYWTGSDPSNGGHTSRYYVMGYSIITIVGVFAANIQYAIIYYGSLQASRKLHNSMLESVLFSTLRFHDTTSRGRLLNRFGKDIEGLDSSTADNFVRSVAYGLNVVITFISITWVGGMPFVLAGCVVLIVYYQAGSIYGQTSRDMRRLDSVTRSPLYSLFGETVSGVAVLRAFGGSTLALHNMMKLADTNLLAFAWSWTVNRWLSARFNLLSAVMVGLTAVAILIAPSVNAAMAGFALSFAGTICHDLLFVVRRFVQLEQSMVAIERLKEFTELKREAAEYVEPRPAASWPENGAIQVEDLVIRYAPDLPSVLHRISFEIAPREKVGIVGPTGCGKSTLALSFFRFVEASEGRIVIDQVDISKIGLTDLRSRLTIIPQDPTILSGTLRSTLDVFEEYDDVEIYSALRRVHLIKEEDTTGEAEVGDVDEVRNKNVFRDLNNPVSEGGDNFSSGEKQLICMARAILKRNKVILMDEATASIDYETDALISKTIREEFSDSTILTIAHRIHTIIDFDKVIVMDRGNIAEFASPAELLRDHKSKFYALCRATGRTEFKNLKALAADAERKRKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJD2</accession>
    <name>A0A1E3JJD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032938.1">
        <property type="nucleotide sequence ID" value="XM_019175206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJD2"/>
    <dbReference type="GeneID" id="30192286"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="10568" checksum="0FC247763505BAA8" modified="2017-01-18" version="1">MAAPGTIITSIPGSTPSGPAYQYNVKMTCTGCSGAVNRVLAKNITAPNAYHISLPKQLVLVWGPSLPPFETVTEKIAKTGKVINEKAVVDDASTLPALEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM57</accession>
    <name>A0A1E3JM57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033186.1">
        <property type="nucleotide sequence ID" value="XM_019174807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM57"/>
    <dbReference type="GeneID" id="30191877"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001669">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000009">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="587"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="693"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO01934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="826" mass="92714" checksum="1017962D92DB6D82" modified="2017-01-18" version="1">MADHLPPAPAAAPVKKEKIVPPSPPLKIRDRDRGCEYLRVGFLGEGGFARVYEVQDHRGSRRAVKVVSKASIKTKKNKTKLWAEIKLHQMLAHPNVVRFDDCFEDEENVYMVLELCHYGSLMDLLRRRKRYSEPEARYYLVQLIAACQYMHQMNVIHRDLKLGNLFLDENMDIKVGDFGLAALIEKPGDRKKTICGTPNYIAPEVLFDTANGHSFEVDVWSVGVILYTLLIGKPPFQTKDVKAIYKRIRENRYEFPTDREISSSAQDLIMSILNTNPDKRPTLDAILSHRWFLDGAFPAYIPTSANDFAPDFRHVSSSQSRRNFAALCHKSKIGIAQSINVEPPRPRTALGPSIMQQERDFKNAVQPDSPISALLNSARQPLVQAPAGIKEPSLLRKLSAASAASTLSPARRGTAGKENHDLGRRPAAMERLGEESEEERAEEEQKPRPGRENELAAQKARIVSQMAAERQQYVEALEKASEGGAAQRQMYEGAKARVAAAPRAAVPLSATLAQPTAASSRPEGSTKPSYGQSTVAESSKPEKSRDYKTTLFETFGQNLTAGLTMSQTDEGFQTPQIESKPEAPSVFVVSWLDYCTKYGMGFAMTDGTVSVHFNDSTSLVLAPGKKHFDDIRPTGSDDLSQNIRRNHLIERYPSDLKNKVYLLKHFENYMLDKLFGDQPYTFEDKELSTGMVFVVKYLRMKHVILFRLSNDVLQFNFYDHTKLILSRDGLVVTVIDRHSVIRTWSLEELLRPVDERLSPKDKKRIEGVVHKVQYARDVLAKIKSHVSTSTKTASVQPAPAKSTAAHDQRAYTARPVGEREIGKPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMW6</accession>
    <name>A0A1E3JMW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L198_02727</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033248.1">
        <property type="nucleotide sequence ID" value="XM_019174869.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191940"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1515"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1224"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1280"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1247"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODO01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2258" mass="256849" checksum="9B5CE873B822BE03" modified="2017-01-18" version="1">MSRGSFRGRGSGSNTRFTGKRRGGGRGGRGGGVAYGIDRPAAQLTREDGTAAAERFEEVKAYDEIDEKLGFWRFESVRSEGEEKVGWLVNMHMTLMQSDVSPNGLAAVDYYFIQDDGGSFKVTIPFEPYFYVTCRGGTETLVEEWLLKQYEGTIVRIEREKKWDLDLPNHLLSAPPVFLKLFFHNTADLYTVRRDLNPLAKSNSEKFTAVDAYADVVSAEAAANGHDDEEKAWGAEDDSRKRKDKEPSECIIDVREHDIAFHLRVAIDLDIRVGLWYSVVSKTGITTLLRIPERVKRADPVIMAYDIETSKQPLKFPDQQTDQIMMISYMIDGMGYLITNREIVAEDIDDFEYTPKDEYPGEFTVFNEPDEAAVIRRWFEHIRDSKPNVIATYNGDSFDFPFVDARAKIHGISMYEEIGFKPDNEEEYKCRATMHMDCFRWVKRDSYLPQGSQGLKAVTTAKLGYNPIELDPELMTPYAIEQPQILAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLNPDEVLRKGTGTLCETLLMVEAFDAHIIMPNRHEDPHGVTYEGHLLASETYVGGHVEALEAGVFRSDIPTHFKVVPGAIQGLIDDLDAALQFSIVEEGNHRLEDVENYDEVKGQIQQALELMRDDPSRFDKPLIYHLDVAAMYPNIMLSNRLQPDSVKKESDCAVCDYNRPDKQCDRRLEWAWRGEYFPAKRDEVNMVRYALEQEMFPGKRSFDPKRRFVDLSPAEQSALLHKRLGDYSRKVYKKTHETKIVTQTAIICQRENSFYIDTVRAFRDRRYEYKGLHKTWKKNLDKAISEGGAVAEVDEAKQMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGATIIQMARQLVEQIGRPLELDTDGIWCMLPGVFPEDFNFKIKGGKKFGVSYPCTMLNHLVHAQFTNDQYHELVDKESGQYMVKKENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNPDGSLAELKGFEVKRRGELQMIKIFQSQIFDKFLLGTTTEECYAQVATVADQWLDILQSKASSLHDDELVDLIAENRSMSKTLAEYAGQKSTSISTAKRLAEFLGEQMVKDKGLACRFIISAKPQGAPVTERAVPVAIFTAEESVKRHYLRKWLKDNSLTDFDLRTILDWEYYTERLGSVIQKLITIPAALQKVQNPVPRIRHPDWLYKRIAMKEDKFQQHKLTDMFAKMKSKDMEDFGEGGKQSGRKLAVVKRRKQREQEKSPEIEELPPKPEDDYSGYIRVMKKKWRQQRQERARARKSGPRQDGTVSSMLRAQTTSLSSKQWDVVQIAVTNRPGEFKLWLSIDGTFQSVKLRVPREFYLNFKETPQQDVLFADRYEVSEVVRTLPRGQATRHLFKLLVDEILFMEGESHFSSLINSPKVEGAFELQVPLVVRALLSFGTSCTLRSGITGGLNRGLDKGFELSDLERPMMTSRHKYLNEGREIQYHFLFHANVDTRHVIGLFSPGAAPRVYVVDRSRTRQNIPSMASFYAERLERLGRTEKGVFPYPEEIEIETTQHTTETSAFKALAKDLGALKRGLNVVALYSPFSHDYYQAKSSVFSDFPFITYRLGKDEEPGIMWQLNTVKRMVGLYLRLSGWLKEQIEIAAHFDVPIGNLAADTAVFLADIEFARRLKQQDMLIWWSSNSRPDLGGNEEDANMSEDLVSPHISNRGCYSSTVLELDITELAINAVLQSALVNEMEGSGTGSMAFDTASHNLDEYAKGAVNSSVMLGDAVLSTQTFGVLKSMLRAWFVDKARATVKGDHSSPAELVVDQFWRWVSSSTSNMFEPALHRFLHGLMRKTFLQLLAEFKRLGTQVVHADFNRIFLLTSKPDAGSAYAFSKYLVAAANSQELFRHLGIEVTQFWNYLAWMDVANYGGVKVSVEAAASRDLPSYKFEMSMDWNIQSFLPSALQPLFERHVAKFIYELYTAKRKAHDSREPLRVIHSLNIDAPGEIASTVNPAKDKERASGAKAISQTLTRNLLTDIAGAKRRQAALHLDPDLDDNLDFPQLPGARTDRTNPTLELIKAITEVFSLASEHSIEVQVLKRNLLDLVGVKEFSGDAAWKAPCESIEVPMVICKRCNAIRDVDLCRDPDRLPVVDSATGEVREPPRKSWTCHKCDSDYDRFQIEQPLIETINKMATAYQTQDVACVKCSQMRSDNLAATCRCGGSFKPTVNKAEARNKLKMIKSGEHNSIGEVHKKMTSMTVCDYHKLPLAGSFVEETLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP76</accession>
    <name>A0A1E3JP76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033189.1">
        <property type="nucleotide sequence ID" value="XM_019174810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP76"/>
    <dbReference type="GeneID" id="30191880"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1232" mass="133096" checksum="15B62297B54346DD" modified="2017-01-18" version="1">MPLGPQLPILGTLSLLARNTGDVLQTFPIDVERITIGRDADCDLRLYYQDVSKIHAELVFDLTTGQASIHAKGGNGFKFHPHNGDTSTYKPPSVVQLNDNDTIILRNKRFLFSYGNAFAQEEVPMSPAVRAATPARPGTPASPAKITSITFSPARKRSSYRMSLVPAGTNFVPFALSPAKNRRHSTLGLGGLGEGAGGSKSKLAQEMHAEAEEETEDALLAVTEGDGGDKIYIEAAEDEEDKEEIVFSAIQTNPFMTPQPKGKAPMRNTSAVPRTRTFTDQAAGNKPLDISTPPPSSPHKSPRKLPVTPVPVPAHVALSTPKGPATLRKALLLRSARKVWHETHATGIDGAMQDGHIEIRRKSTSPRDGSRRKSSSPQDAPPPPDSSSDEDLDMAESEEAAEDFEPEGDGQLRIVFEDGQADISFDSDSSGLESADISLDIPGQGVIRLDDLENELEEEFINESDTDAEESVAQTEGDELHGQESFGEYDGPIRKEMEAAEDQDDEHNELPEEDFDEEDDLATSLPGTPQARSIATNKFFTPQIKHSSGFSQMRRSLGPPMRVPVTPDSHRPFNGGRTPGSLGKPSRRLDLGVPKQEVEEVEQEQEVKPQPAITPVKSTPRKSAAAIVEAKRLHEALATPRTLPAMPASGFKNPVREIKLTHLTPSHPALSHHTPEPESDLEEEQEAPVHSQPQQKRDVPGTPLIDIKKRLDSMRRQSVQRSGAKPANRRATVGFALPSTPSQKASGSGQLGYLSVARNRTMDQAPRTPIFPLLKRELVVEQVTSPDDMQVDEKDESPTPATQSQIVTSPTPNQSVSQQAGPSTPSFAGLRQMMKTPQAAKTPHLSGIRHLYPPLPQRTASPSLTGVKSLLAEPKEVQTPDFTGVKVMLGESKLPQTPSLVGVKRMFGEMKVSETPNMEGLNEMYEEEVEEALGEANSSMEETGIDVEMADKVKQEENGVKVAGKAATKLPRLADSTSARTRHAALAVEESSSRPSRATTRKATTSTAAPQPKFKPSRATRKADPEAAAVTETEPEPTSRSTRSRRGASHKPTESGMSRATRAQSTAEPEDHPVAEDMPPVPALPAAKGRSVSARSTRKASAEVEEIIEEKPSKATPAKMVLSQIEEQPVVEERKSAPTRAKRAAVTAPSATTTGRRTVSAPTRSKASDSAEAPAEKLSAPVRRTKAKITEKENDETLAEEKDEKPVVKRRAATAGASGLPVPSGRVTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPJ8</accession>
    <name>A0A1E3JPJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033319.1">
        <property type="nucleotide sequence ID" value="XM_019174940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPJ8"/>
    <dbReference type="GeneID" id="30192011"/>
    <dbReference type="OrthoDB" id="10334716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="37002" checksum="02EBC2395E81B137" modified="2017-01-18" version="1">MASPLSRALISPVKQDKKARITSLSLSPRKSIKSLFSLSRSSSSPRPSPRSQETSSDHTVITTSAPNEDRAEPTIKLVLKQTPSPVKRKLVVVNRTPPGARSSPKNLDRPHTPASPTPQKARHPAAHLHMSAAPVANIARPSVGRRVTSHTPSQTIKDRPKDRSIRPKSKASKSDRVIPTRQRLLHAIPSRAAEVDVFKFQEEVGEDEEVMDMVMDALEKIQEQGNANCEGMIAQEIERIDTTTLSALLDPSDATTYLQLCMDMALEKLEDLDEELSGYRVRLMSVEEDKSVIISDTRTLFKKRSMQRKLAKESRRMHEKTEARHLSMTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRT3</accession>
    <name>A0A1E3JRT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033606.1">
        <property type="nucleotide sequence ID" value="XM_019174554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRT3"/>
    <dbReference type="GeneID" id="30191616"/>
    <dbReference type="OrthoDB" id="2565097at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="589" mass="63519" checksum="ACC3E2AF9F68A884" modified="2017-01-18" version="1">MSISLIITHPASASISSLPKPISPSPLPTQTPLPIPSRFPPSSRPHLTPSPSGRLFLHSQESHFIWEYDHKGRRVGEMVFGKQDRVNQVVCGDAFVGVLLDGREGVEVMEKESERLGKWKKMKSVEGPGGVVTALASDGKHLLAIGTDEGGLVVCNVQDGTRTDVSLEGHSGASHTVCSRVKLTSGKSISPLLSFAPSLPNTLILPSQTSPTLLRIALTPQTITSLSPFPSPAYEPISSISFSPVTESPDGTRKGGLCALAAGGQVVLVGLDRAVEGSLGKRVGFGQEVGDVVFLDGATLGGKVKGGKGLLVKDLRALDKSPLEFAFGEEVVKAQAKSSQSSKPTTRRVSNTSTTSALGEINTNLPPTSRPATHAPGNKTKAPAPSRPSSSSLASTKPRASSTIVPSQTDRVGREKEERRSTSGPVVRDRARKPLGMSTRTIEVIEEEEAEQESPGPSRITCLVDGALTRQVPEPVEEEEDEEEEEEWQEPGVDLTWALHPPRPSSRTQSQTGATHTRAVVEEGGMSEKEQIAHLRREMAFMHMDMLRMGRDLRNEMKAAVDPLKEEIQTSRVVIEKQRREIERLRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRU3</accession>
    <name>A0A1E3JRU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033650.1">
        <property type="nucleotide sequence ID" value="XM_019174598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRU3"/>
    <dbReference type="GeneID" id="30191662"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000133">
        <property type="entry name" value="Probable tubulin--tyrosine ligase C12B10.04"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="506" mass="56064" checksum="6FDE67ED47ACE133" modified="2017-01-18" version="1">MSSPESEPLSAFVSFPSPYTQSLLVQALVSTLPSLTLSLVQPPEDQPPALQWADYDLMSFDIPHKNPSKYLISSYIYRKALIRKHQLHNTITAYLAKCSHRQIPSILSPLPETYEGETPLGGGAPKGWIVDIQFADELDELLMDDLYELDEGMRANEEKAEGEKRWWILKPGFADRAQGIRMFSSEEELRFIFAEFEPPSSDEEDDEDEDGDDESEDGEEEDGDGDEGTGVMTSQLRHFVIQEYLPRPLLFDIAQIPGEPPAPLEGNKFHLRAYVLVTGAYKVYLANTMLALFSGEPYGPPKTTEDGGLDLRPHLTNTCLQTDAYGAPAPPADLVKLFWELEGLTALSSSTSPSPSGSYAYDSHGSVTKEWLKSTFAKVGEVVSETVKAGAECGSFGLQFMPNAFEIFGVDLILSFPPVSPANALPIPVVTLLEFNASPDFHQSGDRLRPQLLDMFKGVIKHSIVPFFGVETTDEEEVSKENPMKVGEEKWGWRLVGEGEVRGSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRZ2</accession>
    <name>A0A1E3JRZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033700.1">
        <property type="nucleotide sequence ID" value="XM_019174648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRZ2"/>
    <dbReference type="GeneID" id="30191713"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="36160" checksum="6BDD3A284E8DE1EF" modified="2017-01-18" version="1">MTELKPFPASSSTSYHPAPPPPYTDLPNPSLTPHREPSHLALVARTRPRHRMGKSYQNEPKDVLFDGYSDDPKDALMDFEPVLAHPLSAPIDIQAYCTLVYRCIHFKSRGPYSDFYSSPRSESEIREGARAVLWEKKMDRGFFLDEFPCPPGKPSTTTLWTWSEPRKSFMPRFAKSPSDLLEGVPKQFGSYHSILKTNIRAFYPPFLLPMSFADLLKVTEGLYESWTSVIISAKRPQPWRDATIHRQHYWQFKDLGVVDLEAVPRSAMDEDDDDSASDLSDDDPAWDTWDDYKSKASRGTGTGTGMGRWKDWFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JSD4</accession>
    <name>A0A1E3JSD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033627.1">
        <property type="nucleotide sequence ID" value="XM_019174575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JSD4"/>
    <dbReference type="GeneID" id="30191637"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="177" mass="19454" checksum="515B69428C6B08D8" modified="2017-01-18" version="1">MGALIWHVWGRLLGLTAGVYIVWASFWAFLFRKFFWDMMYVPLRTYHGLSRKVPNADGRSGRSGGTLGHAGIIPGKNTEPLVNLVVNIPLLQSFSLVLGIFALVLEYPLPLIEGTAIHRSFILRAVLYFLTGFVGIMVYQCVDPAVYFVIVSGVYVMAMSKGEQIGSGPGGDDRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTG3</accession>
    <name>A0A1E3JTG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory subunit N12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033458.1">
        <property type="nucleotide sequence ID" value="XM_019174406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTG3"/>
    <dbReference type="GeneID" id="30191467"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="3">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="284" mass="31284" checksum="22D35D2954ED7C39" modified="2017-01-18" version="1">MSLQQSLADLHAAYTSAAPDVPQRLADLKLELAQSGLYFAPPTANTQDLVAARSILEIGAFQSLRGGDLKSYARYNFALQPFYDNLRQVIPESPNRPVTLGLHLLGLLSENLLTEFHTVLETLQPEQLNDSFVRLPVDLERWLMEGAYNKVYRAKDRVPRPEFEFLLERLMGTVRGQIASTIESSYPSLPLQHAATLLFYKPTETSSLTDFASNRGWSLSPETQTFTFPRSTKPDIALVAAESSSGVSSSTIDKLKGSGVVRGVPMETMVGPALKLAQQLEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTK8</accession>
    <name>A0A1E3JTK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033508.1">
        <property type="nucleotide sequence ID" value="XM_019174456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTK8"/>
    <dbReference type="GeneID" id="30191517"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="99"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="41464" checksum="5566274D28A4D153" modified="2017-01-18" version="1">MSAPLLPSYMPQSPGNPRVGSPSSPSRSSPSPRSPARPKGGRARSSSPSRSGSYPQRPGWREAGDEERQFLANASKNVEISANVPENKKAGITSNPVVIIPIWIALSSTVILYNKYLYSNLHYPYPVFITSYHLGCAAIGTRILKATTHLLDGLDNIEMTRDLYLKSILPIGVLFSGSLILSNTAYLSLSVSFIQMLKAFTPVAILLISAVFRLQTLNSRLVGIVFLISVGCALAAYGELHFEMFGFLCQASAVAFESSRLVMIQILLQGLKMDPLCSLYYYAPVCATINALFLPFTEGLAPLQEFWRVGSLIMLSNAGVAFGLNVAAVFLIGAAGGLVLTLAGVFKDILLISSSVIFFGSTITPVQVFGYVLALAGLMAYKSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUH0</accession>
    <name>A0A1E3JUH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033623.1">
        <property type="nucleotide sequence ID" value="XM_019174571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUH0"/>
    <dbReference type="GeneID" id="30191633"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000019">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="484"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="776" mass="84910" checksum="8AFD99854B196C0A" modified="2017-01-18" version="1">MSPATPQETFEDLSLESPPVSPTPPPDDARDIGAELPVSPTKIPISSSNSDLSFTLSPPPTEKPDALSLAKDASSTSLEHPHPAQYRPELADEDGDIGGGLPSVPPETPPKPKGPHPLSPLSLSSTHHNSDPRLSRVLTRSPSPSYRSFNLSNGHGGEDSREDLELPASPTRVPLPGSTSSLSLALSPPRSAPSHTLAFREYSSSASLEDQTPFQSHPDQLEEGDGDLSAPFESIPLSTTPPAPTAPAAPLPSSPRDKLSPQNTPDKRRSWGGFGISNGERVAHGQLPEHPPLPPPPLEVQRAKSAGDVPQEDGDEPPDSAKTSASTPTPAPRRAAPPPHPFPWPIPTSPPPPNPKRLSAMSTASNATHVSQASTSTSQPQAMPALGVKGSSTFEKVISHTRPAWLPPKDKTEDVGHLHQWEDMMKHAREHEKIVAKQHEKQKLEKEKRLAAEAPKWEKLLDEKDFSAQRVRNDPEMRRLWFEGIPSHLRGRAWSLAVGNPLALSKDVYKPYVSRARKGLANARFPADLLETIERDLDNTLVTLNVFYRGSPLRDDLKELVCAWLVYRSDEGLGYAPYITLIAGILLLVSPPATAFHTLLNILAGPVLRAFFTPLPSEIAAYYRVLENLQADRYPKIYANCKSLGVGVPQSWFQSLLVEQLGFEASCRVWDQVFLDGEGYVFRAALAIFGFLEPRLYYPDKGEVLSVLEGHNPASLAIMRREKERARLRGEVWSEGVDGTLTSFGLNEGQLFAALEEDGWREKDFERLVLREMPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW73</accession>
    <name>A0A1E3JW73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S small subunit ribosomal protein S24e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033759.1">
        <property type="nucleotide sequence ID" value="XM_019173952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW73"/>
    <dbReference type="GeneID" id="30191004"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="135" mass="15187" checksum="5313DF3C37B82B4E" modified="2017-01-18" version="1">MDPEGPVTLRTSKFITNRLLNRRQFVLTVLHPTRPNVSRSDLSAKLAALYKTEKDQVVVFGLKTKFGGGSSTGFGLIYDDEESQKKFEPKHRLVRAGLADKVVKPSRKLRKERKNRAKKLRGKAKGKAAEPAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG3</accession>
    <name>A0A1E3JWG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033731.1">
        <property type="nucleotide sequence ID" value="XM_019173924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWG3"/>
    <dbReference type="GeneID" id="30190976"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48597" checksum="4B60004BF2198398" modified="2017-01-18" version="1">MVLKMGVSTLVAGMFLTGCANSLLSKYQDMECVEQCDTSTPIAFEQPVWQTLNMFIGEFGCCLPLLWSYYHGREKKTSSGPQASVFSRIVARLPLGSGPTTQPEGYSRVDVHLEEDSEAEDEDAGHFLQGWRMCWMWFPAFFDICGTTLMNVGLILTPVSIFQMSRGALVLWVGVMSVIFLRRHLYLYQWSALIIVTLGVCLVGLSGSLVKGAVSDPVDFVHTLSTAPANDPARVAVGVMLILFAQIFTACQYVVEEKIMSRYRVDPMKAVTLEGFFGLTTTLLAMPFLHLFFHDKSPYFDIPRGWQQIISTPTVLYSCFAIMLSIGSFNFFGLSVTSSVSATTRSTVDTCRTLGIWVVSLALGWEALVWPFSLLQVTGFAMLVYGTFVFNGLLKPIIFPPPPSIHLPHEPELEETGEVPAAGAQGRAGYDVVPENEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWW6</accession>
    <name>A0A1E3JWW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034013.1">
        <property type="nucleotide sequence ID" value="XM_019174206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWW6"/>
    <dbReference type="GeneID" id="30191264"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="599" mass="65068" checksum="BBA0D0E0D479E991" modified="2017-01-18" version="1">MADYKAAKEAFVSDNLGASVSSINAVSLPALATYAIWITLSPHPTRSGFASNYLLNALPILLGVTVFATSPIIYTCALILLALLFHTKSQSSLKQSTKQLKSKGQWLDESDSDEEAAEPASASGSTTVSPVRLPSQVAFSSGVLLSPESAPPISPGFPAGSAQEDPLGIMGVNRRRSLQPGGEGYAFDPLLKGRISPVPLRLGKPRKRKVEEKEETGAKTRLPFLTVYRAHMMLMTVICILAVDFEVFPRWQGKCEQFGTSLMDVGVGSFVFSLGLISTKTLSPPPPAPLPTSPAMNSFALNTTPSSMTSIITSLRKSAPILVLGFLRLIMVKGSDYPEHVTEYGVHWNFFFTLALVPVLAVGVRPLTRWLKWSWIGVIVSLSHQAVLHHYVQDFVLSPVRSNLLLANKEGLASLPGYLAIFLLGLATGDHVLRLSLPPRGRTVSENEEEHEQSHMERKTLDLIMELVGYSVGWWSLLVLWLFAGGEVSRQMANTPYVLWVAAYNTSFLLGYLLLSHFLPTQPTSSSSSSPSSVPPLLEAMNKNSLVIFLVANLLTGLVNVTMETMYVGKWVAMGVLGVYTAGVAWVGWALKGKRVQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ23</accession>
    <name>A0A1E3JZ23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034136.1">
        <property type="nucleotide sequence ID" value="XM_019173431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ23"/>
    <dbReference type="GeneID" id="30190478"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="UAS" evidence="4">
        <location>
            <begin position="174"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="539" mass="60231" checksum="94FF2D9275480BCB" modified="2017-01-18" version="1">MALTQQQQDALDQVLAVTASATDGSRQRDEQLLRENGWNVQATIEQIFNLTDQPDSAPSSAGPSRPTNRSTSAASDQPHAPQSSRRLSGTPTRPRAPGTSGVGLGIWDKVFLPFTFLFSLFTGAWYFMIRTFLPLSFLPHLPYFLRPPSPTQRIPRPAQDPTATSLAFVRDLETLTSASTSLGTLPELYIGPYREFLTHVRKEAVVGMVVLVSSEHEDDEEFKRGTLADRDVVKVLRDENVAVWAADISSREGFQVSQTLLTTSYPSIIFLSLNPSPSSPKLQILSTVAGPPSSTTSPTSILHTLTTSILPRSKPFLNRLKAEKFSLAEARHLRAAQDKALREAEGRDRERMRVEKQKAEAERLRAEREEREKAEKAEFVLGRQVWRRYARKHLLEPSSGPIRVALRTPFTSERHIRQFTPSPSTLPLFTFASTLLIPASQSTPDDPDSFPSSPASIDPTFEGHEKGEEGEEGDWEFNLITSYPRHVIKPVRAGGEEVWELIKKSGGVLFLEKKDGREWNVEKMGDEEEEDEEIVSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZC6</accession>
    <name>A0A1E3JZC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034261.1">
        <property type="nucleotide sequence ID" value="XM_019173556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZC6"/>
    <dbReference type="GeneID" id="30190606"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1120" mass="119946" checksum="FBBE71F675060FC1" modified="2017-01-18" version="1">MPPPDLPPKGAPDAPAQATVQESQPPIAVPTSPPLPALPRPAFVGPTFAVANTPPPVLAPLPPPPQIASTSQPPAPIDIVEEEDELHGDESLNGSAPPPAPAFHQGSSPNKSSSSKSSPTKSLYIHTKDALLHSGVNGLSGLRSHNVHNGWAGSGLPQWPSATGPEGGGGGAVGPGASASPTNGEGPGRANRSVGYGTGPGKSRKSSCANCHHRKIKCDQQRPACSSCVRKGHNCKYLEEDESYRNHQPPRPAKPLSVATVNPLDPSKYPKHLPPQESNNSSSALLPALPMNTHVELGLPITSRPGSTTDRSTPEKPERKKKKDDIREKILNGYDTDSEEETPKEEDKKQDVDVELAALVENEIDELADDGAQDQRSQKRSVSVDDDINGELLELASGPPKKKKKKKPSMQPPLPQVPPSNSMQFIPQLPPNAPLHHRSIRAAPPPLTNSRQLSVSAQSFPPTPGTSNPIGSHLSQRSISNHVSPGDDPYSFPLQNLALSLPTPEAQGILLRGFWSDPILTEGIALLQSQFREDYARMMKRLPARTALGDATTLALLYLILACALRIMPEDTSRLLLAAHNNTPVPRSLSRIISGQPPSAIDPSPLDHRYLDHAEACMTFAKQWDTSTVMTVMYKLVLWRYHNLWDRDSRQVSQAAADLASGIKSAQGQGLGKEWHGLQQADRELRRRIVWALYSADRHESHVPYTIVDVHLGINYPTALTDAELFAAPSTLLALPTSTDGAPTENTAFLLQVQLVRRLTSILDAFATIGPPHVEHERILSYDATLDGYQESLPPAFRVFPVTDTRWDAGMPFLPVQRVRLHAMLFGFRTGVHRTHLGRYLQPQAPIGVRQVISSICLSSLRVQRSAKMLDPIVGLRLFSPQTVFENSAVLCLILYVDKMLMADVALASGGGTGPRTVDFMSMRSGVADALELLDMTVSGPSGSVSIAKKGAQVIRAMINVIDAPLDLTIAQVQMNGAANDNSPVVPDNNGTPNNFAHEAPPSPIFNQIQPIDESAGQAGNGILTRPSSPAAIYSNSTAFRPTRVTPPGATSTPSAPGGTGTPIQAGTSGLAQGQLGPHAQKVISWITAIQGPEGNGMVMDGLLKEPNWVGAWDRVVGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZM5</accession>
    <name>A0A1E3JZM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034369.1">
        <property type="nucleotide sequence ID" value="XM_019173664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZM5"/>
    <dbReference type="GeneID" id="30190714"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="88"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="42204" checksum="3463A28BA0FD8205" modified="2017-01-18" version="1">MSDHMLLDTVDLDLVVKVLSKTIFSPMFVVFLPLTLLSQVGSSHPAFLATCVWTAIICFFALWQHVDRIYSNQATWLLAPPKLKWEDQVVLITGGGSGIGALLAETLAMRNVSVVVLTKYPPQYETINENIHTYICDVSDFKTVQTVAERVRGEVGDPTVIVNNAGIVTGKLLLDLTEEDVQSTFGCNTLANFWVLKAFLPAMLRKGQGHIFTISSLLGLLGAAQMSDYCASKAALISLHQTLRFELDNRYKTPAIRTTLVLPAYILTSLFERIRFPPGRLFDFFCPPVPPHAIVKQIISALDENESRVIRLPFYTNLARFSGEGVGLVPAWMRDLMQWLLGADHVMKGYGPSPDAGERLEVERSQQQEGHGVDIVNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZR4</accession>
    <name>A0A1E3JZR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DEAD box family helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034411.1">
        <property type="nucleotide sequence ID" value="XM_019173706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZR4"/>
    <dbReference type="GeneID" id="30190756"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="329"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="79937" checksum="17F14DACD3677FEA" modified="2017-01-18" version="1">MASLRPVGRVLLRRLLVHQFRPPIHPLPLRRANSTSSASPKIGVKLYPEPPSAEEEQPLPDGADSSSSSLVLRPYQEHAISSCLSALEKGLRRIGVSSPTGSGKTTMFMSLIPQVPFYRSKGKGKARVEDGEEKRKQTLIVVSSVELAQQAEAAAKRLLGPGWTVEVEQARRSATGLADVTVATYQTLNKTERLSKFNPANFKLVIVDEAHHAAAHSYLKLLHYFNQDVTLPSTVEPHTSLTHGNKTPIIGFSATFSRNDQMALSAVFEEIVFHREISAMLKDGWLAPAKMTTVMANLQLEDVELNQQGDFKSSSLATKVDTPEVNDLLLATYLTRARERRSTLIFCVDLTHVSNLTQRFRDAGIDARSVSSNSRADIRKATVAGFGAGEFPVLVNCEVLTEGTDIPEIDCIILARPTKSKNLLVQMVGRGLRLSPETGKSNCYIVDVVDGVSRTNGLVVTPTLLGLSPEDVDVEDKREKRHTKTEDDPLDGLKVERPQERSNPGVKNFKISYVDINDPFKLGFDTREVLQKVTQNAWVACGKNKYVLELLGASTLLAVTPDPDERFPFCITYRQPMPVELIEPGKKNSPWLPPRKIGFGIDLEQAFQVGDKYAEKIMGRERSLGLSRYAAWRQRPVSAKALKMFLSLSKQDESSSAGIVEINGTEVIASSLSAGQVSSWLCAAKNGAKSARGAIDKAEDKKKTKASAKAEKERLHRERNLALPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZY6</accession>
    <name>A0A1E3JZY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034465.1">
        <property type="nucleotide sequence ID" value="XM_019173760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZY6"/>
    <dbReference type="GeneID" id="30190810"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="81"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="501" mass="55832" checksum="DD81AE7DD3B56789" modified="2017-01-18" version="1">MGILNKFKDQFSSSNPEYDFPAPAAPLPLGPDAIYRYRKQRGVNLGSWFSLEQWICPHVFRGAAGPGQSDFDVASGKDAKRNLEEHWDTWITEDDFKWIASKGFNSVRLPVGYYHLCGALPEVLKNTDFEPFHHIYEGAWGRIERAVQTAGNYGLGVLIDLHGAAGAQNHDAHAGLSKGKIGFWDSKSNQASTSLALRFLASKFAPMPHVVGLELLNEPQNHPKLQPWYEKAINYVRTVAPADFPLYCSDAWDTDHFARFVGGRSDFVVLDHHMYRCFTDEDKRMSGYDHANELKGNYRGRFAGQCEAAKGALVVGEWSASLDNGSFGHGMPDGEKDAQRRAFVAAQLELFESHSAGYWYWTFKKGEGWDAGWSAQNGSQAEILPGWVGSKQFKGMPPDHIKQQELSNNHGKCSHTNYWANNGGSPDPTVYAPGFSQGWDDALMFLSAQGTPSELGFIHQWAQRRKPEYEASAGKKLGKAEWEWEHGFKQGVEAAARCCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K071</accession>
    <name>A0A1E3K071_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034521.1">
        <property type="nucleotide sequence ID" value="XM_019173816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K071"/>
    <dbReference type="GeneID" id="30190866"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="72" mass="8159" checksum="60E69D034EEF2680" modified="2017-01-18" version="1">MASFFHIVFVGAVLAAIGAASWFLFPKGQNQTLLRTSTLLTLTACYLMWAITYLAQLHPLINPRRSDLRQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0N8</accession>
    <name>A0A1E3K0N8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034157.1">
        <property type="nucleotide sequence ID" value="XM_019173452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0N8"/>
    <dbReference type="GeneID" id="30190499"/>
    <dbReference type="OrthoDB" id="10404839at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="671" mass="71457" checksum="3C6DC646E4C8C7F5" modified="2017-01-18" version="1">MPSQPDAIYDVSDRFEEDFESIAISRRAASGSAIGEMGQHGCLDPAHQPFGQQLVSPSRFSYEQPPYPSASPAFRAPPYPHLPPDPAPNTYLDNSLRTSGSSSSIGFKALNQPSRHYNSSMDHPIVNAGIPGANHLPGREAAGVGSSFLVKRGRESETMTAYNSKKKSATFDQCRGEWGGGQTGATMGSAAGSTVAHQYQSNPPSTSTPFSSSIDSSAVPHPIETSDAFPFGPLQSGSGINTTPSELPSFGSSASFDTFTSAGIDLMYNNQQQWASPPGFLQPQQTSGLDMMGMGGDFDVAGRDMGTQRQQGSGHGREMWMGGVGRPEGGAYEQVQHQERPASVSAPMAPNQNQQSDSGISPSYVPPSYVFGLPDPGQPLAPPAHNSNAITAPHFDQTFLEDTASSQAASHASALPVTLPPNSSQYAYGMNVPPAGSAPDAASRSADAQFMQPPPPVTQGSSQEQAVAPLQPRNAPHPAPTHFSPSKSKAASDKEELGYEIIGIGKTFPPKFVHTPALVEAFNTVFSTVYSDIYAQKERQTPRPGGVTVMESQALANARSRQDIMKKAAEMHYTKTAKHLRMEGKNQEWSIHEAMRQTEIKAQDEAREIQESVLAQQQMRENAQHAGQVNPPAPPAPFASSSQSSVGITQGTLSGDHGSAEQYQPQRHEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1J2</accession>
    <name>A0A1E3K1J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034162.1">
        <property type="nucleotide sequence ID" value="XM_019173457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1J2"/>
    <dbReference type="GeneID" id="30190504"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="16766" checksum="DB42145DD524F4E5" modified="2017-01-18" version="1">MPVDLGQSSSTASLSLPLTLEPLNRCNNPLPPPANNPSSSSSLDQQESAPAFATDTRSPGAVPHGTPTLEQPGSINPNQVPWGGDQRYKYLLGGAAHEGVLGADKSGDENGENGEEVQSRQKAQRQQRQSTSEPSSVSTPSSNATDAAYEQNKLMPRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2L4</accession>
    <name>A0A1E3K2L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Metal resistance protein ycf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00993</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034891.1">
        <property type="nucleotide sequence ID" value="XM_019173165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190206"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000078">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1271"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="346"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="676"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1011"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1337"/>
            <end position="1573"/>
        </location>
    </feature>
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        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO07414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1581" mass="174156" checksum="93257BBD4E1F5913" modified="2017-01-18" version="1">MEQVPFQALRGHTHGHGCSWPPKIVSTNRDLDLTLCFEHAILLPAPLVITILLGLAQVIRISRKLKRSEAEGGLTWIKRSKLGERICVTKLHFLGAAALFSVVSFALSLKDVATTPLTSVHYLLLSLTWFTLIHLTNFNHHTSRTSSTIALLFYPLYVAVFLVRLRTIIITGQLSSGLTQSTSGRFILARESFWFISIFVGLGSFLLELHSPEKKWQKWRAPWSKEGKIALLDEDEDEEADIVNDLQGGGAVYGKNVYGDVESPISTANIFEILTFSWLTPLLSLGTKKFLGEEDMWALPHEDSAESLSNLVASSWQKEIDSVKAGKKEKPSLKRALFSAYGLPYAIAGLLKAIYDILNFLQPQLLRLLLAFVSSYTTKHPMPPVAGYAISILMFAISNLATGVLHQYFQRCFTTTMRIRGGLVTMIYRKSLVLSNGEKAGRTTGDIVNLQSVDAVRIADVTQYGHIAWSGPFQILIAFVSLYQLVGWQAFMGVAVMVVSLPLNTWASRFNKRFQRQLMKIKDTRTRTLNEILNNIKSIKLYGWEQAFSTRIFEIRNAQELKMLRKIGLAMAGTNFIWQSTPFLVAFVTFATFSLTSDKPLTSEIIFPAISLFQLLSFPMAMFANIINSIIEATVSCNRLESFLAAEELDPNARTLIRPSEDPQGEPKKGDTVINIKKGDFRWLEDSTEPILQDIDLDVKKGELLALVGRVGDGKSSLLGAILGEMTRSDGSVTVRGEIAYFSQNSWILSATVKDNIVFGHRFDKGFYEQVLDACALRQDLAVLSEGDQTEVGEKGVSLSGGQKARICLARAVYARADIYLLDDPLAAVDSHVGRHIFDKVIGPNGLLAGKARILCTNAVTFLPQADSLIMLRKGIVLERGTYADAMNNSASELYKLITGLGKQSAKEEGSGASTPTVVEEAVIEEPEGVEDSEEAEIVTGGESPKQRKAFRQLSHSIMRRSSVVSLRTSKRDALRDLRESAKPKEHSEKGNVKREVYKQYINATSKIGLVAFLLFMALGQGLGVMGNFVLRDWAGSNTPKSEAEDDGTHHISKYLILYGLVGFSGAIFNVLSFATLKLVCALRASKTLHDRSFSALMRSPLSFFELTPTGRILNLFSRDIFVIDEVLIMALGGFFRTGVSVLSVVVVIAFGAPVVLLVFVPLAIIYRMIMKYYLATSRELKRLDAVSRSPIFSFFGETLTGLAVIRGYGQKERFIANNEARVDRNQACYMPAMTINRWLAVRLEALGSCLMFSTALVSVAALVNSSGVDAGLVGLMMSYTISVTGSLNWLVRSASEVEQNIVSVERVLGYSQLPSEAPDFIEDTKPAQGWPQQGSIEFDHFSMKYRPELDFCLRDVSLKFNGGERIGVCGRTGAGKSSLTLALFRILEAAEGRVLIDGVDIANIGLHDLRSIVSIIPQDPQLFEGTLRNNIDPTSASSDAEIWHALEQAHLKDHVSKSMGGTLDAEISEGGSNLSAGQRQLVCFARALLRKTKILVLDEATSSIDLETDEAVQQILRGPDFKGVTTITIAHRINTIMDSDKVLVMSQGRVGEYDTPKALMQKPESLFCSLVTEAGLAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2R8</accession>
    <name>A0A1E3K2R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034783.1">
        <property type="nucleotide sequence ID" value="XM_019173057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2R8"/>
    <dbReference type="GeneID" id="30190098"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="117" mass="12581" checksum="C9B071F62A17F600" modified="2017-01-18" version="1">MVSPGWPCGRRSGRRARDETCSRGKSLLDGLAGVTPSTSNRPPPPRPAVDPPTAPFQSSSKAIKMKSEVDELVGSFGVAMGLRSEKSVGGECQRQPEHRVYSVNAWVKKIRSSVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K304</accession>
    <name>A0A1E3K304_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034886.1">
        <property type="nucleotide sequence ID" value="XM_019173160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K304"/>
    <dbReference type="GeneID" id="30190201"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000002">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="439" mass="48792" checksum="60D02F4E1E0C5EC7" modified="2017-01-18" version="1">MSSDEAHDQAIQIWRYRKLLTMLANSRGAGTSCITLILPPRSQISQAASMLTTEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNRVPTNGLCVFVGTVLNDEGKEKKISFALEPFKPINTSLYMCDSRFHVEALEELLENDSKWGFIIIDGNGSLFGTLAGNTRDIVHKFTVDLPKKHGRGGQSALRFSRLREEARRNYVRKVAELAVQHFITNDKVNVAGLVLAGSAELKTDLSGSDLFDPRLLAKVVKVVDVSYGGENGFNQAIELAADSLANVKFVQEKKLVQKYFDEIALDTGKYCFGIVDTLKGLDMGAVETLIVWENLDTIRNTLRNAAGEEIIVFSNPGDKDRERFMDKATGLEMEQTAEPQPLLEWFAEKYREFGAQLEFITNRSQEGSQFVKGFGGIGGILRYKVAFEDLGDNEDDEDEFYDSDSDSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3G9</accession>
    <name>A0A1E3K3G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035056.1">
        <property type="nucleotide sequence ID" value="XM_019173330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3G9"/>
    <dbReference type="GeneID" id="30190372"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="982" mass="107788" checksum="923A91DFC7147879" modified="2017-01-18" version="1">MESYSQDYSKYRSYDHLTPLGQRQNSYKTSGGSASFEPPGSVSLGSIELPFAASTSRRAENMYGRGEAYGWSLGEKGVPSKSDRPWERDSPRNGKDESEPAEEDDSDHETKPEVVLPSSGPTAKRGSKACVACRKGKNRCEWDPSAKKTTCRRCMLNGTKCVFEKASEKSRGKSATVVELQGEADDRVRSLENAVQALTDSHNQMQTALHHVFKLIPQLSSNGPSPGMAPSTIFTSPISPPQIWPPAGPRLVSNERNNVPGRPKSPQNIASGRKGSVSVKKDKEDFPPLPGYAAPSSHRFGTYGIIPIPSAAPSAHHSPSSSRSSSSSRSPKEYPSALPHESLTAPIQALEALANAADQAATLEGGKEKRGEGSSDEDHTLRAKGKGNLRDEVGEERGRSKKRKRVAIDVTEKNVHSRLMKKTRPDPTPRNPFPDVITKGLVSETEARELWDVFFSGCHYFLPIFDKSYDTFETFVDRTPFSTNGLFAVAAKIRAGNGPPGQTFESCLAEGQGIARSTLFGPVVRKEAVLALVILSVWSQNGWLPCGHALRAGLDMNLHRALDRLAIKDEERSEFEERDLVVSARIWLNCYMHDHLVSLGNGKPLMLRDDSSVQRARELISHPMASETDMKLVASVELVNLRIKILEHLTPLHGKVDTSTITFVKSSFTSLRSWYDEWYNFHKQRGYDDECVLIKLMETERVYAEMWTVCVALRGCAWDKLSKEQQDLAFYARDSAWRCLEIFLRVDNFRKHLKYATHEHLVSVAFAAVFLLKVAILYPTSLSRPLLISQVTELAHLLSNECYAERYALTLRLMLANFRRSTGALSTVPGSPRLAGSASAAHVQGFGGLAMSTLSELDGGLNSFLELPAGTMGQNGNGLDGVSGMGQDVNGAAVGMGMEGDAGIWNMNSLDGFDWSIELSPSFIPVWLQDGNTTDLGLPADGSDSLFLPPELANMFLPANNQQNHMYQFSMPDSGNVGAEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3W1</accession>
    <name>A0A1E3K3W1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035043.1">
        <property type="nucleotide sequence ID" value="XM_019173317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3W1"/>
    <dbReference type="GeneID" id="30190358"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="35"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="41149" checksum="28C3DECE2FCBF1AF" modified="2017-01-18" version="1">MVKVLAILYSGGQSAKEEPRLLGTIENQLGIANWLKEQGHELVVTDDKEGNSSEFQKHLPDTEILITTPFHPGYLTADLIEKAPKLKLCVTAGVGSDHIDLNAANKHKITVAEVSGSNVVSVAEHVLMTILNLVRNFVPAHEQIVNDDWNVAAVARNAFDLEGKVVGTVGAGRIGYRVLQRLQPFDCKELLWFDYTDLPPDAAKAIKARRVEKLEDFVAQCDVITINCPLHEQTRGLFNKELISKMKPGSWLINTARGAIADRTAVKEALASGHLRGYGGDVWDVQPAPQDHPWRHSFNPLDGGNAMVPHYSGTTLDAQKRYAEGTKEIIRRYFQGEEQDPVNLIVVDGEYASKAYGQRAANKKEVSQEKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4M8</accession>
    <name>A0A1E3K4M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034944.1">
        <property type="nucleotide sequence ID" value="XM_019173218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4M8"/>
    <dbReference type="GeneID" id="30190259"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="418"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="550" mass="59415" checksum="065C1721AD43F3B8" modified="2017-01-18" version="1">MPSGAVVSEHSHASAIGTRILAAGGSAVDALIATTIAVNTLNPYHSDLGGGGFAVLKEASPEGAVKCLDFRQCAPAAVTAKLFKKLPAQATAVGGLAVAVPGQMRGFAELHELYGALPWKRLFQESIDLAENGFAFGGDLYEVSNPPNSTNLRDTWLDKDPSYASLIQPDGHIIPQRSIWKRPELAKALRKIAEEGAEAFYKGEIAEALVKAVRDRDGLMTVDDLENYKPIWREALSTKYKDFTLYAPPAPASGAIWLSAMSMLSRFEPEGYGTVTDLHRLTEALRLAYGQRTALGDPAFVDDAEEKQKEWLTKEYIERRKGMIDDKETKDPDYYKPAKVEIVTDAGTSNITTTDSSGLTISVTTTVGLNYGSHIMVPGWGFVLNDSMDDFSVEGRPNQFGYEPQVTNYVAGGKRPLSSSCPYIITHPSGRVYASGGAAGGSTIISSNTQIALSLLAYNHSAAQALSNPRLHNQILPNVSTVERGSNVRGVEVKGFTEEQVEGLRKKGHKVQWVEKAFSTPCAILWTGDGWEAEGDPRKHDSGGSVYIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4S0</accession>
    <name>A0A1E3K4S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetracycline efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034719.1">
        <property type="nucleotide sequence ID" value="XM_019172993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4S0"/>
    <dbReference type="GeneID" id="30190034"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="128"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="668" mass="72508" checksum="84498960348DAE47" modified="2017-01-18" version="1">MTATSPLSPPTTLGVRPTDDAPTPGYESQAPLGRTLTSGSAHAQSALRRMATHETGDYAEGEDRRPEGLDTHDEDQEDNPRDVGRNSENPEGSDEEKNIEGKHSRGKKKEAELQDQTNLLPTKQVILVFCGLTCALFCSLLDQTIVTTALPTLGQVFNRADIAPWVGTAYLLTSTTAQPIYGRISDIFGRKFTLLACLFIFLMGSLACSLAQTMIQLIVFRAIQGLGGGGILTLSMIIISDVVSLKERGKYQGINGVVIALSNSLGPILGGVFTEKVTWRWCFYINLPITSLSIIIIIFLLPLRRVRGSMWGKIKKLDFWGSLLTLAWAVPFLIALSWAGARYSWDSAPVLAPLLIGLALLGVFIFVEAKLISLPLVPMHIFNNRSTAANYFTTFMNGLSFYATLYYLPQYFQVVRGDSAIRSGVLTLPLMLVQTVSSFASGILVSKTGDYWWNLVTGFSIWTVGLGLLSSIGTDTSIAKLCGYQVIVGFGAGQTFQTSLVAIQASVERKDMATATGLRNFLRMLGGTIALAACTSIVNNSVKKNLQGVLGDAQYQIILNDPTQAQSLGLSASQFAAVTAAYAQGIREVFWFCTPCIGICVPVTAFLVKKISLKREDDAVKKAESKAWVESKKAKKKARSNRLGSEDTAVASERETQNKKSSEESHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5M7</accession>
    <name>A0A1E3K5M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035009.1">
        <property type="nucleotide sequence ID" value="XM_019173283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5M7"/>
    <dbReference type="GeneID" id="30190324"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="815"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="435"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="845" mass="89301" checksum="B5FC63F1471DB4E1" modified="2017-01-18" version="1">MDPPEQPPPAQQPPEQHPEADPPQSFFTMTIAVPGLPPPSPGPGQEGDEPAGGEHNGPGARAMIYTFQIGAGPPPGEGEHGNANHPPLPPDFFSQFAQPPGAPAPGGNAPEGADGAAPPPAGGPPAWLFAPFLEFLLPRRDPQPNPEKAAELLRSLPTVGKRLLKRVDNVVAAQDVDSYEDEEERGWKCGICLEGMSARQEEEVKDDKKVDETIKRGEEKGEEKGEDTTDKKEKTEDKKDSQEEPKKTTGVKALPCNHLFHGDCLEPWFATHHTCPTCRLDLDPLYTLNSPPRASRTARTESIRPARTGAGSTRASANAHPYARGDRSEGSERPQPPSRQASSSSIPPAGPSTTTPGAAAGDGSEQAPTEQRQEDGQPQRPVPRRSQTSHHFFIFSNSPFPPTPRGEQPPAPATGAPAQHSASGSVPPPQTANTESTSSADAPDASSPAAASTSAPSQPEAASLERSSAPEPSSRPGSPHREGHEDNNGHNAAHDLLRQLDIPSLLDGLFGIERPPAPPSTDGAPEEGGQEIRASSAEASAQPARSASAPVEGSGPAPEGNTGALPADANPAAPNGAPEPDAQHRAHMQMIQSTMDLISRMARAGGDRPPPLPTGQQGGPGLPAGRPDGLPAGLPAGLPSFLFSGPPMPRAEGEGTPGGSRSGTPGGEFPSMPQQPEEPSKPPFVPQSLESWTEEKEKVLGWRCEAPECMYGPTIGEEDEDSEMPAVEGEDKQDKEMINIFSPLQPSISLEAAKQAHVDDHQFTILACSHRWHRGCLEGAARSAEREIRDDGEGKGWVRCERCRNDGWVVPRELEGKGKGREVPIKASATTSVVGKKRNREDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6C4</accession>
    <name>A0A1E3K6C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035467.1">
        <property type="nucleotide sequence ID" value="XM_019172525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6C4"/>
    <dbReference type="GeneID" id="30189556"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="32"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="53017" checksum="EDE5A4A16BB18C57" modified="2017-01-18" version="1">MVNVNYTTTSSDLVWTDDDGTEYIYNLGDIGFVIACMALVWLMVPGVGFFYSGLLRRKNALSMIFLSVVGVAVGSFQWFFWGYSLAFSDTGSSFIGDLRYFCLKGVLAQPSAGSDRVPALVFAIYQCMFCLITGVLAIGGFAERSRIGPVMVFLFCWLTIVYCPIANWTWNSNGWSFVMGGLDFAGGTPVHISSGTASLAIALYLGKRRGYGTERLAYKPHNTAFVVLGTVFLWFGWFGFNGGSALSANLRAVQACIVTNLAASCGGLTWMMLDYRLERKWSAVGFCSGAISGLVGITPAAGFVGAPAAVAIGFVTAVACNFATKLKFLIHVDETLDVFASHGIGGMVGNIMTALFAQASVAGFDGITEIDGGWFDHNYVQLGYQIADLTAGFAYSFVMTTIICWILHFIPGLRLRASEDAEIVGIDDAYLGEFAYDYVGTDPELRLHRVDSRPHLTSGDVIADNGSNGHESSSEKVEPHTAGNAAVGGGRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6E0</accession>
    <name>A0A1E3K6E0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035505.1">
        <property type="nucleotide sequence ID" value="XM_019172563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6E0"/>
    <dbReference type="GeneID" id="30189595"/>
    <dbReference type="OrthoDB" id="2565259at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="355" mass="39462" checksum="C95E4B4DD11CD5FB" modified="2017-01-18" version="1">MRKHAFTVYGGFESDQPRGLEEPVQGACTSKPLPRLPTAPLDTQLVFSQNPHSRSPSCPSHPFALSNSSRTSLMISPMSSWHFGVPDTPEECSDLLGDWFEREEKKVFLQQRPLRELPIEDDSSNSRLTTPPKPIHLPPTPPSAKKAKRRSPTESRSSLSSSIGSIIASTRDRPPTLMNPLAIGGWGREWERGFNHRKFRESAGSVTEEDDSEATTSSESSAASPAPSSLLERRMSESLSLASLGFSPVPLPHPFSQRRTRPRRPPTPYEREKEPGKRLDESWLDFSEDGEDARVWEDDEATVKAGSSRWSAILSETDQISTPSETDSRPTEASQIRDAYLASTFCRIVVELMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6F8</accession>
    <name>A0A1E3K6F8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035585.1">
        <property type="nucleotide sequence ID" value="XM_019172643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6F8"/>
    <dbReference type="GeneID" id="30189676"/>
    <dbReference type="OrthoDB" id="2563021at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012430066" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="69689" checksum="897B3BEFC7493239" modified="2017-01-18" version="1">MALLALLLPPTRACAASDQIQAFQFALSTALPVLPVAYTCPSPLQVSRTSYSNAKTDDPKPPYSMVALVHEQLYDAAGMQYERVYSVTVGLGQLDKVTEVAHPWGNGTQFIACMWSANAVSGGCQDLFTVVPSADLTAAAYQSTSSTCRTPNVLESWVTPANETLDVSVTGVSGDLAINAWPPACATGSDIQFTPKNGTAPYTLLIAPAAHPPLNITSSDAAPMNYTVRLTHGQAFMAALYDSAGNSWAYGPLHAGYSDDVKCLGVATGEEVDDPAAGYGLGALVGGVAGAFVVGALGAGLLFFFLFRRPSRPKRSESTEDLYANPRPYRTSSHHTTHSNTASLYTKSLLPNDTPEFDTPATLYDPHMAGPGGYPQGHVKRGSAGTVGTQGRESISSLRPFPRPPLHQRSSSGEYVNPYTPSPPQGGNYRDNIILADFGAGQRRGSGSPRSMVRPVEGDNGHSQETSYSSRRSAPVPGISPRLPASPGPSSHGRFPSAPAPSSPIPRFDPFNPPTQPLPPTPFLQHQNRSGSFHSLPGVGESPPASPGRMRNVYVVHADGGAGADVTIQLPGPNPHTHIIELPPNYRRTPSPPRSSPSLTPLMPGGDDFSPPPLRGGGELHLVRSRASALSGLSVQTGTGDMGADELRARAEAAIAEKDRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7G1</accession>
    <name>A0A1E3K7G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035648.1">
        <property type="nucleotide sequence ID" value="XM_019172706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7G1"/>
    <dbReference type="GeneID" id="30189739"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="81"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="53285" checksum="BEFEEFF57018B735" modified="2017-01-18" version="1">MPPPASRAAITRLLALTANQGCRGCGRSHSHSIAAPTDLPPGNADYAFEMAASTLRFGAHATREVGMDFANLIREMPSVDRSRAKIGVFTDPNVAKLQVMEVVEESLLREGLDFVVFDKVSVEPTDKSWGSAVDFARSSHLTHFLAVGGGSSMDTAKAANLLANHPESDMFDFINAPIGKGLPITKKLSPLIAIPTTAGTGSETTGTAILDIPSLRFKTGIASRALKPTLGIVDLHNTATCPKEVSIAAGLDVLFHSLESWTAVPYHERTPRPTNPILRPAYQGSNPISDIFSRWALETTIKYLPRIARDPFGDVEARSQMLLAASTAGIGFGNAGVHMCHAFSYPISSLNKGRPKETQYHHPSYNPEIPLIPHGVAVSLTAPAVFNFTAPSSPERHREALRVFLGKDRVHEADATKDSDLGAKLGEEIQKFLDLVEVPRGLSKVGYSSGDIASLVEGCLPQRRVLDLAPVLAKDDKAEEREQLAHIVEKSLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9E6</accession>
    <name>A0A1E3K9E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035727.1">
        <property type="nucleotide sequence ID" value="XM_019172785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9E6"/>
    <dbReference type="GeneID" id="30189821"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF1">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="586" mass="63123" checksum="72EE938E8E356969" modified="2017-01-18" version="1">MVNLTYGALLTSSDGAVSFEPLGTDIISTLAGEQTAYDPGDIAWVLTSAALIVFMLPGLGYLYSGLSRRRNALSMLFLSMVSLGVISFQWFFIGYSLVFSESGGSFWGDGRNVGFRNVLERPIPETNGKLPEIVFATYQMMFAALVPAVLLGAAAERSRMLPAMIFMFCWTTLVYDPLAHWVWSVNGWANKWGILETPANDTFITDAGGVPVEIASGTGGLAYSYFIGKRRGYGTERVLFKPSNVGNVVLGTVFLWVGWLGFNGGSCFGASLKAALAVFNTNLAGSVGGVVWLIMDFRLERKWSVVGYCTGAIAGLVAVTPAAGYVGAPAAALIGLVSAAVSNLATRVKVSMRVDDPMDIFAVHALAGVVGVVMTGLFTQASVAANDGFSEIDGGWLDHHYVQLGKQLVWVVVGMGWTFVVTYAIMFVINLIPGCHFRATEEAEIVGMDEVELGEYVADYAFHQRDLEGEYEAHTLSRAPSATKLHLRGVQKDGESSHSSQHRQDLPPTMPRGGAAVAHVNDSDGETMVYSEASRSQSRGRSRPPRAHMGTLAEGEDMEMREVNGGARHHHQQPPNGEAFDISQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H8K6</accession>
    <name>A0A1E3H8K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_08319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000079">
        <property type="protein sequence ID" value="ODN72660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027736.1">
        <property type="nucleotide sequence ID" value="XM_019180284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H8K6"/>
    <dbReference type="GeneID" id="30197529"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN72660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25504" checksum="ED397D8D20CCAD1C" modified="2017-01-18" version="1">MEGTTPQHFDAFASSIRDYQHLLSSSSDPLSELDVKRFLKEGLSSHMLVLDVENALEQKVLTLYTISVADLIALMSKRVTVCAAQLAAFQSHQAASRPFPRPAPAQASRPNQARPAQTPIKAISAAPAPVAPAVPPTAAEAQAWLDNTLRLPPGLEGARAREYLRQRGLCFRCRQQGHISLGCPTFQAPVASLASMPPQTPAQPSPLAPPGPTQESVPLLYVQARLSADGPSYQTLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD87</accession>
    <name>A0A1E3HD87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027823.1">
        <property type="nucleotide sequence ID" value="XM_019180194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD87"/>
    <dbReference type="GeneID" id="30197436"/>
    <dbReference type="OrthoDB" id="10316016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17410" checksum="07ABAD88A258D81B" modified="2017-01-18" version="1">MSSLTKIEQQEAVSEEKEEERQHEVNCRTRRTLLLEYRASLKERALMYGVRSTSYRQLVGNYPIVPSPLRQSFIPEESPIVDDEPESDGEEVAVVQKAEATLANTGFKFEDGPGELPFLRSEEDDFPTSWADDEVEDTCFLPSFLTRTTCSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HHP7</accession>
    <name>A0A1E3HHP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027905.1">
        <property type="nucleotide sequence ID" value="XM_019180136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HHP7"/>
    <dbReference type="GeneID" id="30197376"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="857" mass="97985" checksum="5C44A063D8D594D8" modified="2017-01-18" version="1" fragment="single">KEVLEHILGIAEHVKLREQSVRAGVVRDKVKEKLEGHESGRQPLRDLQETWDNAVHKANGKVKVMQDRQKHTFANLRETKQALDQLGTRREDIADQINKLKKKIERERLEKETCKTNIGKCEAILAEPREDHEVELRKAKEERRYREKERDEQELGRQYERESHELKDIDQAINRLHHEKSTFESVERRKEDSARQASPSISFLLDYLKDNPDSFEGKVHKPLMISVNVPNRQYAWQVEACTNWPQRQTFICEKKADYDHLIALNGRPLPQKYIKNTGRWNPHRNSGPPKVQLYLALQEVTTDTVNPSRPCTVERLNEFGFDGFAIDFVDADPGVIAYLQSVCKMHITAVTQKPSERVRTDELPSLGFKQWGTAKDWTRSNQSTYGRKAYSQIITAKTESRSFNIVIDTEAVAKKVDEIAKLRRKKEEAEQPHGALRDKISVVIGQKKEIHAEGHAIEEKIKALMYSSKRYTKAAHDIQLFKEKLVRLEGLPSYEAERTKLNDMRIKNARDRLRPLAASTNYCDTVMDNCADLIAATFRQVQATTNKKMIDDKVKSGSARGMVLRDRYETASKAFNRAKALTNNKWNEIKARLKPTDRTVREEVTKRAKDPTTLPSVDQVLNDLNTVKNQLEMSVNIPTAVIKQWERRTKELEAAQKIVDEEEEELAELKEDITDTLAKFNPALNTLVTAVSNKFSEAFERVKCRGEVGVDRSAGSDYGKWGIKIMVAYRDSDDLAVLSGSHQSGGERSLATVTYLMSLSEMSRTPFSLVDEINQGMDQRAERAVHNQLVDVTCGSESGQYFLITPKLLNGLEYHPKMKVLIINNGIHLPDPYDLTQRYGALKASLNKYRSTHGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV38</accession>
    <name>A0A1E3HV38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028203.1">
        <property type="nucleotide sequence ID" value="XM_019179836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV38"/>
    <dbReference type="GeneID" id="30197066"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129385" description="RING-type domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33916" checksum="2BAA117AEA792526" modified="2017-01-18" version="1">MLSAFPPPSKILLYGLLLASLALRCAAYIPAVAINDTDGLNLTDSSSIDIAWTDPSGVSFQLQADVLTGGTTSGALVHFAESTMGSNVSTTTPWIAFISCDRNESVASDEWDVFTLARDRGAVSAFHRGGGAGDRGGEGEREREERAGEGEGEGRKKVDDEESVAMRQLDRDDSKVGFVAEQYNPAESKIEHDNPFHPIITDDNSISLSTLPIAASSSTTGFQTPPHDTSTSILDSAAAAAAVGGEGGEGKGEKEEEQHCPICLVEFEDGDDLRAVASISELSAMSKRFQQPLITLRYTNTYHTFFPHLQPHPLPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1I9</accession>
    <name>A0A1E3I1I9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028311.1">
        <property type="nucleotide sequence ID" value="XM_019179694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1I9"/>
    <dbReference type="GeneID" id="30196917"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="877" mass="99919" checksum="A8B2E6C1C316349A" modified="2017-01-18" version="1">MTYLSSALAGPGPSSWLYRLSLRAPPSSSRAFNSSSKLFAASQRPRKPPPTPPKRRKAVPLQSPKPHKPAKATHSSDPPRPVSKYPKKLDLPIANVIFLPPPPDYDISPVLQQLLDALDGGKIDIILPVWSHLVDLDAVSRLKDAHFRQIAQTISKVLTRRTAPDLGRMAIKQPLEYGLFLNMAIEAAVRHHIGGLTMFMFRAMERGRPGDVARAYDQTKAKMRLLQGKDEKDLVSWDRQKRLAARLEGPGLRTLTLANVAALTLLDQCDKEALYSMLDADINLRPQSVYNFGPIYRMFRRISKGDKLYDKFRVNLDNLLLAVQCYHPPVFVKRIDAYSHAKSYSGLYSLYDKVLESTEGKGAFIMTRDLDDFASHMRLARDISLPPVVWLAFMRAFEWHSQPDRIAEMVDTIFPARQLRINSFFLAQAMVHMSVISSRRGLSRSIQAKARAWVDEYWRRLTSNGWHMEDQVFSRRVKSLAVLIKKERRLEGEVDNLYEAAKAGHLGKIGPKTRAAFVESFMAGRNLARALEVFSAFPHNPSSFRPNEWSKNVAEHDFTEATGQFIRFLAMWKWDDKVPMTYCRYILAIIAENKVPIEPRTLGPLLSIQISSGLPIIPTVDAILSVLPTRDMPTNAMVRWTEVLAGMLTKWTHVSTPNARELEAGLYILQRASTEELYGRKRIREYDMWTRYLRPAAKTDQVDNTTRSAFIDAAMDCFPGGYSAMSTFLHFEIIHTLLMRPDRLGFGEGWKRWNSLLADRQVEPEWYDRMLRLLLLTDRTFAPLIVKSAFAASAVPADQAFWLRAEDAGLIRELGLGEELEIRRQEMAGWEKGWVDTLVRYGREDGDVVLPEESRKLQEKEEVGEEAEPDYEVEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I3Q9</accession>
    <name>A0A1E3I3Q9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028318.1">
        <property type="nucleotide sequence ID" value="XM_019179701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I3Q9"/>
    <dbReference type="GeneID" id="30196924"/>
    <dbReference type="OrthoDB" id="2575734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16291" checksum="73928B34317B9A22" modified="2017-01-18" version="1">MFSLRTLPHPCTLRIIHLLPPFFALLTAFFLVLSGVTGTRVGFYFLRVQYWGETEAGGEQGGGEVWEVGGLGSCEVGQECTGETTSPAHWGSIHSLLIFHLASIPISSPPFTTRELRLHRGSTMCPSCKTKEEARVAAEQEAEQAAANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5L8</accession>
    <name>A0A1E3I5L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cleavage and polyadenylation specificity factor subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028375.1">
        <property type="nucleotide sequence ID" value="XM_019179607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5L8"/>
    <dbReference type="GeneID" id="30196828"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="682" mass="70501" checksum="322732481E258C53" modified="2017-01-18" version="1">MSVPLPSDPPPISDAVPPKSDHPASAKPIPRSRPTPIALSSSPSKEKDTASGAGPGGGGGGGLGATPGSYRYRAGAATSVGKSFQDDNWRDRSPAPPGTLGSVSGSGAKSAGLQGSQTGTKVPEKTIGFEKRDLGSLKSSPGVGVDSGLSREREKKKVVEEKDEDGKTTLSHVPCRFFKAGACTAGESCPFSHAAPDSAKREVCQWFLKGNCKFAHKCALAHVRPGEPMSMDRKNKKAAQLEARERDGKPLNGESNGRRDDSVASPVPIRSALSSSIQSPPARQIGSSPMREPFGPPSGALPNSPPAAGFAHSLTRAHPAFASSPNRPSPLSASFGAVGSGLAAGSVPGPLSLKQGNPLSTLRPPVTTAPFSSSFSHSSLAIERPSNTVAAPLSASFAGDAPSLHRSIWSRSDQPPQPLSPRKPIPRPIKRDTVFEDEDDHGEEFLPSSLSDLLTPQERARRMSRRDSDGEAYSPSYAQRPVWTGERLAQSAGATMGQKGFLQGLWSANGEDARKHRNSSSNAQDLTFGPTTAQPSGHRTSLLTQQRSPGSASPTSPGMSTSAFGAPALNGIGSNDPYLIRLDPSSPSQRALLDHAPGQSLPGGLASALSRLHMHGPRSPANLAVGSPPAAGGLGLGGRGGLGDGWRVDEHEGEGEDGVGTPLGGAGVKREEHDEGLFAMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBX4</accession>
    <name>A0A1E3IBX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial protein with role in iron accumulation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028645.1">
        <property type="nucleotide sequence ID" value="XM_019179397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBX4"/>
    <dbReference type="GeneID" id="30196606"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="313"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN86102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="526" mass="56371" checksum="1F7CE8A46A4A051E" modified="2017-01-18" version="1">MSITLRLSSRHHPRLSSSAPALIPIPRLAAKRYSRLCALSVDTPEQAGVGCRARREWANGQLGLGGVPRVARRSGGVLGIRSHSTKPTSTTKDKPQHAHTHKHEDGEECDHGHDHSHSGIFHTHAHDHSEGAEQLMEALSKGQMDRGTRITLLGLGSNVALTISKGLAGLWMNSASLLAEAGHSLSDLLGDFVTLATWRISRKPATDAFPWGYSKFETFGTLTVSVILVGGAVGIGLHSYHLLLQTLLPYLETFPPGTLLRSLAPHLPPSIPSPLLELFHSHGPSALPHDHAGEHVHSHGVEAATSGAILNPHAAWFALASVVVKEWLYRLTSKVANEEHSPVLKANALHHRADALTSLVALSSILGSSFGGYTFLDPLGGICVSFFILHQGLSLSKVAFLELLDAGVDKSTKASIERIVGGLVDGKDLLGVRNVRGVKSGGQTYLDLTVVVPPHMTVVDSHNVEQRVREVVMRKRKEVREVKIHVHGDDPNELLVVQDGDGGKVAKKGNGKVVVGVTSDFGREGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICF2</accession>
    <name>A0A1E3ICF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028669.1">
        <property type="nucleotide sequence ID" value="XM_019179313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICF2"/>
    <dbReference type="GeneID" id="30196519"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="396" mass="42726" checksum="B8BF6D4E441D42BC" modified="2017-01-18" version="1">MTLLRPRTAPRSLALTRTYRPISRFNHSSASTSATSQVASAVSDTVASLRDTFRQATEFLHSPLYDGVEEKGLRMLVFGKPGSGKGTLSSRLIEHYDIAFVSTGDVLRKEIADKSEVGKKAESIVASGGLVSDELMLEIVKAELDRLKGKSFILDGFPRTLHQGQLLDNVLNQENRPLNMVVHLNVPDSVIMARIAARWVHLPSGRVYNTTYSAPKVPGKDDVTGESLTKRPDDTPETFSKRLRAYYESTAPLLEYFEENYPESLHSISGSSSDEVLSAPATSAFTKQASRSDAASSASAFSSPTTIISASSSSPSSPSSSSSSSDAGDECPIETSKQNAALDKLWPQLVDLIEPFKLERKTAAAVPGAEGLEKVRSAADDLRDGREEGVGRAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE12</accession>
    <name>A0A1E3IE12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028819.1">
        <property type="nucleotide sequence ID" value="XM_019179202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE12"/>
    <dbReference type="GeneID" id="30196401"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129698" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="177" mass="18819" checksum="48FE93F52E5F5226" modified="2017-01-18" version="1">MLFSTFFTVPLLALSFLTPASASPLAKRYTGVKIQSYKDGKCLSPNSDTNANGVWVVSVPCDNAKTWDINPGSGSVKLSGTNFVLDAGTGKDNNEGVKIWQSYPGVFQQTWFLTDDKRIAITGGNQCLDQGDNGPQTYACTPYNTNQVWNIIEGGGGTPSSSSSSATPSRTCVAWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEB3</accession>
    <name>A0A1E3IEB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028634.1">
        <property type="nucleotide sequence ID" value="XM_019179386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEB3"/>
    <dbReference type="GeneID" id="30196595"/>
    <dbReference type="OrthoDB" id="2575858at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="372" mass="40972" checksum="BD9F1ABF2B14DE7B" modified="2017-01-18" version="1">MEEQSSPSEDGSSSSPGLDAGASSSDAPPSTRQDSFNTFMKSIQTQFTKLKSSKSAGSSSAEPEVMELVPEEEREPVSLYSERALEEAIDDVTREIQENLAYQRLGQACLVDPATRNALPSIEHVYTAYRDIMDNATLHDTIHSFVSEKMELERNLALEAVNQGEIGDLGFAYCFHPDVDTTPGSWGLNMSISPGWGGNNLVHIAPVEGIKFGNEEVRSWFAEGEKSVMAETGKRLATEGTELVSNMKRYPDPRVSPMFEWDTMDERIEQYDWHGIGKSIKETLAGTIDETIAANGEQRREGGFSGQGEQRNIWLQPITALTEDGLSASLRWSSKDGFFDGTGKPDEIDIGSLVEGGLEAWRDIKGKKMVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEE1</accession>
    <name>A0A1E3IEE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028673.1">
        <property type="nucleotide sequence ID" value="XM_019179317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEE1"/>
    <dbReference type="GeneID" id="30196524"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="19725" checksum="D5F001ECAA1DE476" modified="2017-01-18" version="1">MPRNRQTSTQNSAASSSRRPQISAPILQSENSFSSRFGPLASVRDTGSSASTSAPTAEEQSSPSQEASTRSAPARRDNRRHGMQLPSSASASASRNQQPFRGNAEDSDQSTEFEEDFSSSCDSCSEDDDDARRRESGSIVIGVETSMSRLGIRGNSGSQNGDDSGSECAGSCSSSGEECSESDSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFC1</accession>
    <name>A0A1E3IFC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAMK/CAMK1/CAMK1-CMK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028899.1">
        <property type="nucleotide sequence ID" value="XM_019179141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFC1"/>
    <dbReference type="GeneID" id="30196338"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="495" mass="54347" checksum="75D7C61BD4EC9739" modified="2017-01-18" version="1">MPVDMTPRHKMGISDFRDAILSQPPSFKKKKEYKIEELLGRGAFGKVVRATWTPPGGEKKEVALKIINKKLVKGNEQAVMDEISVLKGLDHPHIVHVWDNFESRDKYYLAFELAVGGELFDRISERGKFTEKDAVDCIRQVLQATAYLHSHNIAHRDLKPENILYKTRDVNSPLVIADFGIARHLETEDEEVEEAAGSFGYAAPEVLMAKPHGLRVDCWSIGVIAYTLLSGYPPFRSDDRMGLLVEMTRAKIMFHDRYWSKVSGPAKEFVKAMLEVDPKKRPTAAQALHHEATTENDLSDAIRANFDAKRKWRSALRMIQASNRIRSSASSRSNTLSPDSSTPASPGTPAREAAQAILTPLSMSDEDPMSDYLSADDSSRRVSLMSNEGELGQGQASGQDSNGALKGKPAVARPGQHRQSTLKAGHARSGSLPFALPEAPEPKVVKAEADEAARPDIKVNGERQTETGLQTPPPTAAGSGKMMGSIKGMMKGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFK5</accession>
    <name>A0A1E3IFK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028940.1">
        <property type="nucleotide sequence ID" value="XM_019179022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFK5"/>
    <dbReference type="GeneID" id="30196215"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16637" checksum="7DD14038532FBDD5" modified="2017-01-18" version="1">MPTTSNADGDTANETVDTKTKKEYKIHPFYRSGNVHFITTDDVIFSCDIDRLASVFVDDKVLGKKVLEFITNDSFFAEGFHGWINRLSGSWGLAVYQAVFKKEPDIECSTRCNCGRLPPYMKPRCYINYDGWKRDLSVSLFGDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFK8</accession>
    <name>A0A1E3IFK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_07007</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028943.1">
        <property type="nucleotide sequence ID" value="XM_019179025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFK8"/>
    <dbReference type="GeneID" id="30196218"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="162"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="957" mass="101694" checksum="20D329079A0F0A7C" modified="2017-01-18" version="1">MSDVEMASASAKIIDGTAIAKNIRTSISKSIAELQATNPTFHQPHLVIFQLGSNPASATYIRMKLKAAEESGMTVEHIKIPSDAESGALKGSGVRAVLEAVKKANQDEKVSGILVQLPLEGAGKQEEKSVVDAVDVSKDVDGFHPENIGLLSSRISEPYFTPCTPAGAIKLIESTGFKLAGSNVVVLGRSDIVGTPVCALLRKKDATVTQCHSRTQDIESIVKRADVVVAAIGQAEFVKGEWLKEGAIVIDVGTNYIPDASKKSGQRLVGDVHFESASKVASFITPVPGGVGPMTVAELMNNTFQAAKRAYTSRRAKQLTPLALELKENVPSDIEIAVAQTPKPVADIADEIGVHPDEVESYGRYKAKIELSVLDRLKDRLDGKYIVVAGITPTPLGEGKSTTTIGLAQALGAHLQKNAIACVRQPSQGPTFGIKGGAAGGGYSQVIPMTEFNLHLTGDIHAITAANNLLAAAIDARMFHESTQTDKGLFTRLCPAKKGVRTFSKPMLARLHKLGIDKTNPNDLTEAEAAKFARLDIDPSTLTWNRVLDTNDRYLRKITVGQAPTEKGLTRETAFDIAVASECMAVLALSKDLADMRQRLGRMVVASSKAGDPVTAEDIGCAGAMAVLMKDAIKPTIMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLAGVEKGDEEGRSGYVITEAGFGADIGMEKFCNIKTRVSGLKPNAVVLVATIRALKMHGGGPAVTPGKPLDAVYVEENLELLEKGCANLGKHIENAKKFGLKVVVAINKFSNDTDAEMALVQKYALNVGADYAVPADHWARGGLGAIDLANAVIDACASPSTFDFLYDLNQPLVKKMEIIAKEMYGADGIKLSEEAEKEVERYEAQGYGGLPICMAKTALSLSDDPSKKGVPTGFTLPIRNVRLSAGASFVYPLVGDMSTMPGLTTRPGFYDIDLNPETGDIEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFY9</accession>
    <name>A0A1E3IFY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028828.1">
        <property type="nucleotide sequence ID" value="XM_019179211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFY9"/>
    <dbReference type="GeneID" id="30196410"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="546" mass="61093" checksum="6AD4013692CD5D73" modified="2017-01-18" version="1">MSNPVPFVEEPVRKVRVDVESILAVEEPPKSTWKGKIWDTFDRPPLERKLLFKVDAIILTFASIGYFLKNLDQTNVSNAFLTGMKEDLGMYGNQLVTSTSIWTVGYVIGQLPSNLLLTRVEPRWVLPALELGWGIATLGSYAVKSYKSLYALRFLVGVFESGFYPGMHYLLGSWYTPAEIGKRAMIFWLAGSLGQMFSGLLQAAASRNLDGVHGIEGWRWLFIIDAIITLPLAIAGFIFFPPQPLQGKKTWWLSDEEFALAQRRLTKIGRAGKSPWSLEKVKRLLLSWHTYFLPVLYIIWNNQWPQAPVGYYLKSFNSAPYPGGDKRYSTSDINQLPLPQTAIFVVVAASWAWVSDGFLRGNRWIFVYIGAIISIIIGVIGIKIDLYANVTGTLFFYWFSNIGQGAGPLILTFINEICSDDTEKRALLVGAANDFAYVVQAIVPNFVWKTVDFPQARKGWTYSVSLNVALIFWITAILVLLRRDRRRAESAENPPALEGKDHLEGFGALSESGSSDRDGVPRLNGKEEEEGATTPGSLTGSLDQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFZ9</accession>
    <name>A0A1E3IFZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium/sodium efflux P-type ATPase, fungal-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028838.1">
        <property type="nucleotide sequence ID" value="XM_019179221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFZ9"/>
    <dbReference type="GeneID" id="30196422"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN86846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117588" checksum="4CDB9142A57FEFCC" modified="2017-01-18" version="1">MSSDKVTTNQNEKQLDRADTGKTAVTESLPFKAHTALSEKVLEALGSNPTTGLKESEVPPKLDQYGLNRLKPPKKPSVFKIILRQIGNAMTLILIAAMATSFGTTDWISGGVIAALVLLNVSVGAYTEWQAEKTVASLESVGAPQATVVRTREGSGEGDTKTIPVEEVVPGDIVLLKNGDIVPADGRILDGHISNLECDEAFLTGESLPVAKQSEPIDEEDCPVGDRLCMVFSGSQVTKGRARVIITHTGMGTEIGKIAQALEGKAKNNRKGFGAFWWKTKVLLGVEETTPLQIKLNKLAYFLLAWAIIIAIIVVASTGFQNIPLSMATYAVAAAVSILPASLIAVVSLTLARASTDLASRNALVRRMDAIEALAGVENVCSDKTGTLTVGRMVVRKFWVPTIDHRPSHPSPLDTKGGQAYSFETGSDPFYPRGVVRADQSTDSSSSSEDPDDREVENQEQVVHVEELEDGLRKLALCASLCNVATLSRPVDEDSQWEANGDPTEVALQVAAHKLGHGKPFLTHHGKHASAGGKVGKADSVRSGHSARPLVFGVNGHFEQLVEHPFDSTVKRMSIAYTFHPADSSSHAQPQDGYVACFLKGAVERVFERCTKVGDKGDELTEDKKDDVLRKVDALAAQGLRVLALCGKTYPGKMADEIKHMPRDGFEQDFTFLGLAGIYDPPRKESPGAVADCYRAGITPRMLTGDHPATATAIALSIGILEKSYGKESVMTGQQFDALSDEEVDALPELPLVVARCAPETKVRMVDAIHRRGQKTVMTGDGVNDSPALKRADVGVGMGTGSDVAKQSSRIVLSDDNFSTIIRAIRKGRSVFKNLAKFLLYLLSGNLAEIIVLMIGLAFKDQNGQSVFPLSPVAALWINTLAAGPPALALGLEPTAVDAMEQPPSSFHQIFTLEFYIDLIFYGFLIGSLSLVNFVIVLWGYFSGNLGMECNEGDSDICSSVFQARATCFATLVIILMIHALECKHFYKGLWQINLRDNRILLWCVVVLVLTTFPVVYIPRINDDVFLIGGLKWEWGIVFGMIFVYLLAAEGYKYVKRVWKRRHDPVQAGKGGDKTLKMESTIAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGF5</accession>
    <name>A0A1E3IGF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028813.1">
        <property type="nucleotide sequence ID" value="XM_019179196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGF5"/>
    <dbReference type="GeneID" id="30196395"/>
    <dbReference type="OrthoDB" id="2568950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129804" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11136" checksum="AC87F4A3C29C06F4" modified="2017-01-18" version="1">MFKPITLFTTLALIGTAVSAADWRLLANKPSGQSIAAFQADFETTCPIFDTSNPDGARATFFRAGDFQGKNTDTQALVFCTYNAADGSVYAVTRELVESLGGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM2</accession>
    <name>A0A1E3IGM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029092.1">
        <property type="nucleotide sequence ID" value="XM_019178998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM2"/>
    <dbReference type="GeneID" id="30196190"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="155" mass="16812" checksum="D9FC1A7898846561" modified="2017-01-18" version="1">MSTQQPLQSASSTSLAKVPPVDDSPQPDKVHLKVLVISGQNHVYSFEPDCTVGRVKELVWSSWPKEWTDPAQPPFPSYLRILHSGKILQDDTSLSSNKLPAGPSSSPPTVVHISVRSFSIKGDDDPKKPSAHRGLSRQSVRAADDEVGGCKCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN8</accession>
    <name>A0A1E3IHN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029171.1">
        <property type="nucleotide sequence ID" value="XM_019178894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHN8"/>
    <dbReference type="GeneID" id="30196078"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="37928" checksum="F9AA96E9877BA547" modified="2017-01-18" version="1">MSDAAKFSFGKFDYICEHAALVICPMLGDEQGIAPTCYARNVQLGKQIIFQPATCIVHIAALIMTGIMLYHVRSKYTAVGRKEIVLFFYMYMFVELFAIFLDSGIIPTANKVYPWFAAIYAGCVAALHWCLILNGFFLRISSLVVGGVCFGIAIATFKGTSSSFSPTNAVGLFITYLVFPLICILVYFVSQMLLVVRTLDDRWVIGDLLFMAGFYVAGILVLIAFSVTICDAISHYIDGVFFFTLAMLFTVMMVYKYWDSITKEDLEFSVGSKQAVWEVKDPLLAPSAEYYEDDAQSAFRGGGGSLVGGYNGNQYYGNAPYANGQAQQGQYAQQQYGYGQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJJ0</accession>
    <name>A0A1E3IJJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029325.1">
        <property type="nucleotide sequence ID" value="XM_019178624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJJ0"/>
    <dbReference type="GeneID" id="30195781"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="665"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="822" mass="89446" checksum="51BFB9811C2BC465" modified="2017-01-18" version="1">MTYPTLPRSESASSADPEPRTPELTSHAPPPAAGGNDTKDPELRCKWADCSHEAESPDLLYDHLCNQHVGRKSTNNLCLTCGWAGCGVKCVKRDHITSHLRVHTPLKPHPCAVCGKTFKRPQDLKKHERIHTTEHHQLHKLSKAPTTTDPAFNSRLSLSSTTRPDRPRSPLSHSLSPKSSSSSHSMHSSSPFEHLLAPQFPHDKSVSPTPSALALLHKKQHEELAAYQQKEMLVLQQLAFNQRQSQTYAAQLAAEQFGGTKGVKRGQEDGLEGLLADMKKRKVEPVYNQDMIQRLNALVPPSMPSNFPAMPNMGYNQFNNNSFNQFGSYPSLPALNNNMYSNMTPQPTYNLPPFPVPQIKTEADLAMFNEFMISLGRDTSTSNNAQTQPMAPSGSGSGTSSGSDSRTPGFAGSSSGSPLSDQGGVEDLFNPEELASLGLAGMPGIPMGSSHNSPTDVHGLSQSPSDRESPANVSFGGLYPSLDTVRGRTHSAPDVSIDHTRRPIANLPRNSVAGTGQGTGQQQKPYMSNIYNAYSQNQEYINFNDMSLPHPQSHGNQPAGHDYASFDSLARSKNAFPTATLAPKDFYKKTYMHVEPLGTAVSHRARESAERTDMGDEDEDEGDDAVYPDIDEEGSDTPKIPVRAFIIPSSTSPTISEADLKLPAISPSHVEPGQDLPPLESISHYRQHGSVSSASSGTASELGTPRGQSPRKEVPTKRHTEDEIVRGVKRLELGPDAPAESSSSESTPAPVSSRSTVSPPPAGLTVSDQQELRRKHADLIKSWLVAVNMEWRRKQMEAEFEERRSTILGSVEENAREEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK77</accession>
    <name>A0A1E3IK77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029179.1">
        <property type="nucleotide sequence ID" value="XM_019178902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK77"/>
    <dbReference type="GeneID" id="30196086"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="151"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="394" mass="42337" checksum="E2485D824CA0C114" modified="2017-01-18" version="1">MVIQAAYRRALNAPRPAFLTRAYASATSGPVSFALNDEQRGIQELATQFTKDVIVPQAAEYDRSMAYPWPIIKEAHSLGLLNTHIPEAYGGPELGLMECAIISESLAYGCSGMQTAIEANGLAEAPLIVAASHEQKLKYLGRMAEEPLVAAYGVTEPGAGSDVAGIKTKAEKKGDKWILNGSKMWCFVLAITDPTVAPTKGMTGFIVDGDSVGIELGKKEINMGQRCSDTRMVTFQDVEVPEENVLGKPGEGFKVAMKAFDITRPLVSAAAVGLAQRALEEATKYAQERKTMGQAIINHQGVAFMLADMSIGVEAARALVWKAAWAKDAGQRNTFYASMAKAFAGQTAVQNANLGVQVFGGAGFNTEMPMEKLYRDAKIYELYEGTNACTEQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL67</accession>
    <name>A0A1E3IL67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell cycle checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029260.1">
        <property type="nucleotide sequence ID" value="XM_019178777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL67"/>
    <dbReference type="GeneID" id="30195935"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39687" checksum="774611607C2625D5" modified="2017-01-18" version="1">MSAPRDDRNDGRPVFVAETEDVREFARLLRGVGLKHNAIMEVQESMMIVTVEDSRTLCALSYIPTSIFSTWTFHQPTDDPPMFEFSLDSMLQCLNIFGNAGSSGKDFNIKAKKRWAGEGDGLNLGGEEREDDRRFTRDKRGMTGMRMEWMGPGYELTLLLQDEHKGPTTTCSLRTLEPEEILNPPFHLEDLNLNMIMQSDSFRNALLDLPPSSNRITITAKPPYNGEDSEDDRAADADESDANVRRRRKVRQEQGQFIIKAEGDLGTVELEHPNDRDIMQSFACVEGGMTFSYHSVHFAHLAKALQGSIKICLQIDDEGVLNAQIMVAEGDDIGGHRGLLEYKLQALEDEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMR9</accession>
    <name>A0A1E3IMR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029624.1">
        <property type="nucleotide sequence ID" value="XM_019178468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMR9"/>
    <dbReference type="GeneID" id="30195620"/>
    <dbReference type="OrthoDB" id="2570040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="269" mass="30558" checksum="5D702282A7125EFD" modified="2017-01-18" version="1">MSDEEQTLLPEPASPCANFNVSTVSIRVHKQCDGQLSELHLEPECELDNARRDIWHFCLNFSAWWATFYAQPVLLMINWGVDQRPPYVHSNHPDTNVRALSLMAAQHSQLSYYGFESLSINHLLKMPNGMRVKRVRELVMYLKRCRTSPLTSPGQSPPGAPVMHPGHIVTQGMYWTYIILLYRPYLIEMGGGPNLIPEALQRCLECTQDIVDMAHYMVDRHGVVKAPLSWQHILYVGSTILIFKLPASPTSQKDNVYGHSTPFASSNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRA1</accession>
    <name>A0A1E3IRA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029763.1">
        <property type="nucleotide sequence ID" value="XM_019178325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRA1"/>
    <dbReference type="GeneID" id="30195471"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="226" mass="24148" checksum="6DD83A0747E97852" modified="2017-01-18" version="1">MATEIPTPRYDFYQTPSELILAIYLKGYDKVKDDVKVDFETTSIKITLPPLPSGPSPETQSLTLSPLASVLAPGSSFRVLGTKLELKLQKGEAVSWPTLLADPTKPPVAQQAGPSSSSAAGASAVSGGASKSKSEGVAQKKKEKTNWDKFDVEEEENDASDPNAGGDAALQKFFSQLYGDADDDTRRAMIKSFTESGGTTLSTDWSNIGKETTPIRPPEGVEAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS55</accession>
    <name>A0A1E3IS55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030066.1">
        <property type="nucleotide sequence ID" value="XM_019178027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS55"/>
    <dbReference type="GeneID" id="30195168"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15484" checksum="0AA0E0F9596B084D" modified="2017-01-18" version="1">MGQQRQKSNIEAYLETKRKLLPARPTPHDALARSTEQGVYLIDIRPTRNRKEEGLIPGAIVIDRNVLEWRLDHTSPWSILEAREPSFTPILFCNEGYASSLAAQTLVEIGVERATDVDGGFRKWKDDGLPVLKEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS59</accession>
    <name>A0A1E3IS59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029848.1">
        <property type="nucleotide sequence ID" value="XM_019178129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS59"/>
    <dbReference type="GeneID" id="30195274"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="246" mass="26300" checksum="32A109B0580CF16B" modified="2017-01-18" version="1">MAHFNQPYQQYPHAAQPSNLQFYNAAPYDARPEGSMASAYGGNMGSMGSMNLGGSSIDNGRWWEAFGTGGFDGEPSLMEELGINPSHILQKSLTVLNPLSKVSGNIMDDADLAGPFVFCFAFAFFLLLSGKPQFSYIYGVGLLGTTAIYLLLNLMSETGIDAYRTASVLGYCLLPMVGLGGLGMGVGIDSAVGYVLSVVSIAWCTHSASAIFVAVLRMDHQRLLVAYPIGLLYGCFALLSIFNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISS9</accession>
    <name>A0A1E3ISS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029863.1">
        <property type="nucleotide sequence ID" value="XM_019178144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISS9"/>
    <dbReference type="GeneID" id="30195289"/>
    <dbReference type="OrthoDB" id="2570580at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="49298" checksum="F6FD0D79D1C0ECE9" modified="2017-01-18" version="1">MSHYHIFLPPPPACVPPLDSFHNTPRVAPPPLEFHTLSAPPRHDESFQNLSCIEEEATQDSAQESLSASARLEPPSAGLRRSRSPTPQPAFGSGVLGSRGFKDKLADRKNTQSKEEEIVQMPPPSLPLPWMAQKKTSQGEKRPAEVSEGSDRPGKKVLLQPRPPRASTLLPVLPSIISQQSQANPSPHDSEDSRSDHSLGSSFNTTATSTSQAPLPPTAVDGNTSIANFPAWSVPIAKLSSLQEVLRARPEPAIRGLPDAGFNQKRYTLIVCIVSVDSAVERQRKANQGPRSRGIGTEGGTFWVGKWSITSPPVGADPEMSCDVKLWDQCARQWGDEKLKRGDVVLLENVELKPASAREPPHLNITPSTNPKITILFRTIPSFTTASRSDYIYRRPNTILPDYGEKKEVVKGDRQLRPDLRLGKSDVGIRKVGDVVAWFEEWLGVGNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITT8</accession>
    <name>A0A1E3ITT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030164.1">
        <property type="nucleotide sequence ID" value="XM_019177780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITT8"/>
    <dbReference type="GeneID" id="30194914"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11575" checksum="A299ADDF6E8316E5" modified="2017-01-18" version="1">MVWGYFGSLLYIGLLFTNAIAILNEERFLARIGWSTRSHAAANQGFGHSPTPHLYDAPGSATSFGGGGSGEGPGVKAKLVNLISATRTLMRIPLIVMNVVVIVYEVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT1</accession>
    <name>A0A1E3IVT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030150.1">
        <property type="nucleotide sequence ID" value="XM_019177766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT1"/>
    <dbReference type="GeneID" id="30194900"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF38">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="40848" checksum="F4125CA9EA2A8BDC" modified="2017-01-18" version="1">MSAALLATPSPSIKRPSPATSSQTLKRPRHASVSPTDMGDDSGTSDNEGGDDERAKIARKEARVIRNRQSAQRSRNARKLHLQHLEKRVIELEAENQALKSNPNTSTTPLVSHSTLPSASPATSSDLDVFSFAHDLGLPSQLVGGGVNLTSVAPPPADVKDSFEPSPLSHSPTMASTTGQVDSLQAENAALKQRVTLLENLVKQVVAVANLSGQSQPPANLSSHAPIDWLSVFTSPSAATTSGLSSTLSPGLPPTVPSFPTSHTNLASGDLISRSLTREARCGPAAGEGGYFNAFFGGGVGEGREAIEAGGEGDCGAGKAAGLDITVPTFEYGSEQLEGFSGGEGAWAHWDEAMRVLVDGIEGGQEVKEEIWNGNLRGDLGLDLFGLESGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW53</accession>
    <name>A0A1E3IW53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030419.1">
        <property type="nucleotide sequence ID" value="XM_019177668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194800"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2219"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2512" mass="274133" checksum="3CCE7EF2BF318DBC" modified="2017-01-18" version="1">MASLFSSQSPSRPLVLNSPAARVSVPVPASPLAAWVTSQVLAQDFQDAIANDDEPVPEVEDDEDEPKAPSQEPQIKLLAKFLNFVADRVAQDASEELAQVLFAAYSRFNELFLASINVHSLVQSFDPETRAEVLKAYFKAFAAAREQLGDKVQIAHPSSLLEAAKAGKTELYALFGGQGVNEHYFSELALLYDTYTPFVAPVISEVTDLLISLSHKAGQDGYTYYSSGLDVLSWLDGSATRPSVEYLGSIPLSMPLIGVTQLAQYVVSCRVADLSPADMREIFKGATGHSQGVVSAVAVASSNSWSSLYENILKAVKQLFYIGLRGQEGFPLLSLDPKIVSDSVENNEGVPSPMLSVNGLGVKALDGHIKKVNSHLPHNSQIGISLHNGPTNFVATGPAKALYGLATALRKVMAPSGLDQSKVPFSKRKAVFTMRFLPVNVPYHSHYLEGATQKVEKDLGEELWSTSALGMPIYHTEDGSDLRSAASLTFSLCDQIFTKPIHWVKACNFPPTATHAIDFGPGGNSGIGPLTSRVLEGRGVRVVVVGEKGKAAAEFYDASNIKREPVWASEWSPKLVKTLDGKVHIDTPFSRLLGKPPIMVAGMTPSTVGANLVAATLDAGYHIELAGGGHYNAKALRSKVAEIQRRVKPGVGITLNALYINQRQFSFQFPLWQEMRKEGLPIEGFCVAAGIPSSEKATEIITALKDAGIKHISFKPGSVEGLRQVVNIAAANPDYPIILQWTGGRAGGHHSCEDFHQPIIATYPSIRQNPNISLIAGSGFGGADDVWPYISGEWSVKMFGLQPMPFDGVLYASRVMVAKEADTSASVKQLIVDCPGVDDAAWEGTYDKPTGGILTVRSELGEPIHKVATRGVKLWREFDDTVFAQPREKRAAWLENKRDYVIDRLNKDFNKPWFGEKADGTVTADIGKMTYEEITRRMVRLMYVGKQERWIDVSLRNLVGDWLRRVEERFAGVDGIRTKESLLQSFSSLDKPLPTIDSFFKSYPRAQSQLVAAEDKAFFLAICQRPGQKPVPFIPILDSSFEVWFKKDSLWAAEDIDAVFDQDPQRVCILQGPMAVKQSNVVDEPIKDLLGNIEDLLAKKILNEYYSGDESKIPAIDYIGAKPGNPKTGLFAETVSGDVRTFKIGKAVPSVDDFLEVIAGPNVSWLRAALTSVNVVHGTGYISNPFRRIFTPRTGQTVEIKSVAGQATSVTVYGAARSFGPHPADFKAVELTFDPKTNAIDLVLNEERRGSAVPLKFNFAYHPEQGYAPIHEVVNGRTKAIKDFYWRLWFGDNEQLPALKLDTTFTCPEVAVDATEVQKFCDVVGNQGEAFTVARNEKIQAPMDFAIVMGWQSVMKAIFPDDIDGDLLKLVHLSNGFRVMEGVAPLRAGDVCSAEARVVSVINSDSGKTVKVKGYVLRAGEPVIEISSSFLYRGKFVDYENTFETADESDYVVELTKANSVGILQAKPWFEWDDDSVPLDVGTTLTFKTKSELRYRDKATFSAVKVTGAAFIRDSTKALIQVATIDYEAHNLHGNPVLEYLKRHGQAIGNPVALETGYSLIQDPTTAVFTTPATNEPYSKISGDFNPIHVNPYFANLASLPGTITHGMWSSAATRKYIESVVANNHPERVISYDVNFVGMVLPGDDIQVKLTHTAMRDGKQVIKVESFNQRGEKVIDGTSEVLQPPTTYVFTGQGSQEVGMGMELYASSEVARAVWDAADAHLTSTYGFSIVDIVKNNPKELTIHFGGIKGQAIRQRYMDLTYDTIDESGAVKTLPLFGDIDLYTTSYTFSHPQGLLFATQYTQIALVVTEKAAFDDMKAKGLIDQNASFAGHSLGEYSALAAIADVLPISSLADVVFFRGITMQRAVKRDAEGKSQYAMMAANPSRVGKSFNEMALREIVDTISKQKSTLLQIVNLNVANQQYVCAGELRALAALTNVLNMLKVQKLDLEKLSTMMSVEELKEKLAEIIDGCWELMEEKEKKDGSVILDRGFATIPLPGIDVPFHSRYLWPGVLSFRNYLVKKIDPSQLNPDKLINKYIPNLIAEPFEVTKAYVQKIFDETASPRMSSVIENWEKDAWGSAAQRQKLAYNILTECLAYQFASPVRWIETQDVLFTHAKFERLIEVGPSPVLSGMATRTLKAKYEAQDGATSLDRAILCHAKNYKEVYYAFEDEAEEAPAPAAGSSAPAPAVAAAPVAAAPAPVAASAGPAAAVEDVPPKAVDTVRVIVAQKLKKQASEIPLSKSLKELSGGKSTLQNEILGDLQVEFASAPEKGEDLPLDELGAALGVGYSALGKHSMSLTNRMIASKFPGGFNITAARGHLNKQWGLGPLRTDAALFFGIVSEPPKRLGSEAEAKAFLDALAQSYASYSGITLSSGAAAGGAGGAAGGGAVMNSEEFDKFVLKQEEQAQREIELLSRYLGKDVRSGEKKADLEKASVEELQAKIDAIKLEHGDAYLDGISPVFSALKARTFDSSWNWVRQSSIQLFYDIIHGELDPSTVFNDPPRYRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW78</accession>
    <name>A0A1E3IW78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030476.1">
        <property type="nucleotide sequence ID" value="XM_019177725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW78"/>
    <dbReference type="GeneID" id="30194859"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="85380" checksum="5590CED3AA7B16A0" modified="2017-01-18" version="1">MARRGWTIAAFAAGFIIAVGMLGFKVWSPPDLDISSAAQKRNDILPEIPALVLPSTVLPAKYKHDIAAHLPYPFITGRHINTTVHPIPTLLALNHTSSSDTPEYSSTDDNFWGKQVAYTAPSYEKAAVIGFDWASVTRMDMSVKHERFDRMLWNNGKPQTTYWDTTRWGLGRGIREPYNDWNKVTGRMSLTSSRTDLFTKLYRVHYSLVGVQDRRRGIYHIYGFPQGSPPSLGNATEMLSKALGEEGLERKVSSNLANVRDDDLPTTWLMRKLQAPTPYCPLLIQLTLPPLVNLSNTPTTDPEWTNVEYYNAPPGLAGVAVADGCGWTLGFSGGVDAEGIAHSDMWFWSWRSFRKPSLISTSDEMLTAIPDVLLSSGQGLTSFALRLYITFGQDKSISKHLSRGTRYLLTLADCYMFVIMLARGFFDGDGVMIGVLMPFFLTAVANLIICFVAVYYIDEKWRKEDIVRPNASPIPPASFIPLTRPHNILEASISKLATNFTLSDLTINFHAITASPTEVGSYPQWPLVIVAWQLVQVGVLCAQDNYGPRSRYEGTAPCRICSGSVQFPITPLDHPFYTSHDTYVKEEGKRLKEHSEKLEEKAERLREKAKSLEEKGLQAEKRNEVLEELDGVGGGGVKEKGDDIEVPLVDNGGNVAKVNAVEASLKTEPPYPSDVEPPLVPPIHAAREDSNLLSPSELADLIREVEWGLKRTRNLLATDYAMGPCGHLYHLSCLRVYLLENGTCTVCARRLPELDDWNVLKKGEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWF0</accession>
    <name>A0A1E3IWF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030382.1">
        <property type="nucleotide sequence ID" value="XM_019177631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWF0"/>
    <dbReference type="GeneID" id="30194762"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="200"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="34496" checksum="5F520EF95DC203CC" modified="2017-01-18" version="1">MLTTQTRTYPTVSSGILRLKSDPSHVVGQLLVTPILTHADSFFGAEVSGVDWSQTIPESLVKELVALQDKYGVLVFRKTGMDNTRHIAFSHQLGSKLEVNPFYYGKENDRVREDYLWDVGNMELDGSPVRPESRRWHHSLGNCLWHTAKRSKYSLLLSHGNPVQGGSWTHFADTRQAYADLPEEKKAMLEDLIIEHEQTGPDGRKVLYLAAHAKQVVGWDLEKSQKLIWELIDWCTQPKYVFSMEWHDGGDMVWWDNRQSMHRANPYTANMTARDVRRATVIDDGPLAFGVTAEEVKDAESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXM1</accession>
    <name>A0A1E3IXM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030488.1">
        <property type="nucleotide sequence ID" value="XM_019177335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXM1"/>
    <dbReference type="GeneID" id="30194458"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130017" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="59"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="562" mass="60678" checksum="B1E9F4B6E501941A" modified="2017-01-18" version="1">MRIHTLFTLLSTVLTAALTAASPLTILKERADDPVATLTGAGPDGGDVEITGVNHPTFQQDYWGGIPYAKPPTGDLRFSPPQTYAYESTIFTAQISSPACMQDSDLTMSEDCLYLNVYTPSGSSGSDASLPVMVWVFGGGFQTGDAGWFNASRNLQYGVDSGKPFVFVALQYRLGAFGWGPNQATNVGLKDIKQGLSWVQSNIAAFGGDPSKVSIGNHKLFAYTHGQEQVTLFGESAGAMAIMESGAPSGTPLGPAGSTWEDAYQFFLDHVGCKSPSDGSTEWACLKALSADQLLDGQKATKSQTQWVDSRLYGPSIDGDVIPYSPHTLISNGKVANIPFIQGNNKDEGTSFAPTTLEGPESGRNLIRLIEPVPPSNATLDSLLDLYPADPTVGSPYDTGNDTFGLQPAYKRFASIIGDLKFQAPRRHFLREANKHGNTATWTYQFEQSTPGSAAQRGVWHASEIPYVYGLARPGTGQSAEYTDVDGALSDAMMEYWINFAHYSDPNGPSGATPNFTSWPAHDIFANTNILRLKGDDIEVFKDDFREEGMQFMQDNSGEFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXN3</accession>
    <name>A0A1E3IXN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030293.1">
        <property type="nucleotide sequence ID" value="XM_019177542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXN3"/>
    <dbReference type="GeneID" id="30194672"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="20403" checksum="35D041B38772BF79" modified="2017-01-18" version="1">MADSTPLPKIPIIAPVGTNHDEAATSGAGPPKPFTEAQVEEFREQDRWLPIANVARIMKSSLPSSAKVSKEAKECVQECVSEFISFITSEAAEKCLNEKRKTLNGEDILTSMRALGFDNYEGVLRVYLAKYRDSHHSIPKRHQHHDDDGDDHDHAGPKKRGRGRASGAAGGTNGEGKGKRRNGDDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXU7</accession>
    <name>A0A1E3IXU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030568.1">
        <property type="nucleotide sequence ID" value="XM_019177415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXU7"/>
    <dbReference type="GeneID" id="30194541"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="98"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="190" mass="20629" checksum="2E9DE9E78940AA8E" modified="2017-01-18" version="1">MPHADSSYVPDDIKTKTEFYDHVVAHLEALLEGERYWVTNLAQASAILYHSFLASPLYGGDAFTPVVNWTGFYLHPPSYPNISADSPLLLGPYHGRPACLSITPTPGKGVCADAFLTQKTLIVPDVEAYPGHIACDGDTKSEVVVPLRNGGGKVIGVLDLDSTKLDTFGEEDRLGLERVADALARNCDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY28</accession>
    <name>A0A1E3IY28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030609.1">
        <property type="nucleotide sequence ID" value="XM_019177456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY28"/>
    <dbReference type="GeneID" id="30194582"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1029" mass="111204" checksum="BC26A003F93610CF" modified="2017-01-18" version="1">MSTPGRPSSGIPTPASRRPRSSLGPGHPRPDDDDAMDRALQDVLRTRPPSSLRNHDDAPFESSSHLSASYGLPAPRTPGVSRQRTPSALGGAPVTPSAASRSVSRAGLGLRSSLANSTTAPFTPRRTSMASSTTSTTPFARRPESRASERDPGTSKWVPVVGERVRISSMGYEGTLRFYGATEFKEGVWAGVELEGGFKGKGKNDGNVGGVQYFSCPPNCGIFVTAVKLSQPTTGASRPSSVASSHRSQASYTLSGRATPSMSGRATPSRPPSVTPGRVPRTVSSAARSRPSISGHLDDDLPSRTALGNSTSANTLDSRFTVGSRASKYAGMTAKQLDTARAGSASKLGQSTSTVTGTTPKVSRISMGLGTPARGPRQSVSNLVTPRARAPRSSGLHDMPPPPSPGNINRVLTARQVEALEEEIRELKRRNGELEEDLKQAPELKEEREDDGEEVEELRGEAEKAKADVAFLRSQLETAETNANDAVRILEELQGEHTAQQEDIDQKAKELQDLRKELKLAAERAEEELSAGMEAKKEQVREMLERAESAELELSEMKALVDELTNAGQQMISLNETKQYELEERLRELEDKNRSLDEKLQKAREEQEKSLLPPSPSTRQREAATAAEIDNETLNAQVKHLQSKLNHLEEEVDEARAQAETDAEAWKNKINRVKESEKAVREEGGVLRTEIKELKEQANGARGKIGELEGALKENQVALEGARAEIESLRVEASEAAGMRAALQSASANEKALTAAQAEVAELKKTLQAAIESSSKAAADAEGQVGDLEAKIASLEAEIETLKKTAESNISNNLPTPPTKLSSSSSSSEDTEKKIRGFQHIIQDLSAENADLKEQCESLREEVALMKEEVKLLEETAGDLPSGGAGNQKELLEAKTTIKELNREVAELETLIETKIYREDELETRVSSLEREVDRHRKSSASSDRPPHSATSTHFSHGSDNSHSSSTATGGSNREVERCELCEGPHDLDACPVFAGNVTGEEKKGGKWCEDCESSEHDTVECPMAEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B9</accession>
    <name>A0A1E3J0B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030691.1">
        <property type="nucleotide sequence ID" value="XM_019177538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B9"/>
    <dbReference type="GeneID" id="30194668"/>
    <dbReference type="OrthoDB" id="10630868at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="173" mass="18690" checksum="B82DF3225BB0A994" modified="2017-01-18" version="1">MDQQQQSRRYLRSQGDAPPNAVNNVDPDHVATSQSPLTPPPSEPPVPLSPVIDGLAPRSLQSEVGNGTSNSNPPPSIHDTPSSAINTAPQALVQGAHPPVPTVEFLMQQNQFLLSSLANMRDELRSFRQSQSREPTPAHPPSHRPHAPKLKRFVVLETSEEGRETGGARARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0J1</accession>
    <name>A0A1E3J0J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030696.1">
        <property type="nucleotide sequence ID" value="XM_019177115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0J1"/>
    <dbReference type="GeneID" id="30194229"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="439" mass="49814" checksum="9A5CD83B68184BB5" modified="2017-01-18" version="1">MSTDEETPPSSSLAKKTTSTLLDGNHTFPALYVCYLLRSKASPQSNRTYVGSTPDPPRRIRQHNGELKQGAWATSKFRPWEMQMIVYGQFEWAWQKPELSRHLRLQSAESRKETVPIFSKDTKRNWVERKICVAYALLALPPFSRLPLHIRFFVTEAKDMYESIHHTVLAHEPLPKTRKKPVNPLHLIPQAVNPSVTTMLDLGGVSGATGKRRESTRGVQSRDGPIDVKDTEFRQGRRVWGKWEEVRERIALDEDVARCCRCEKMVDCHDQLSFALCPSDRLEPCLCITHLQCLAEHLLQDSPSRSSLLPHRGSCPCCLEEIEWGEVIRACYGRRDGIEREMQKQKPKAHNERNNKPKADSESETDTTNSLGTGSGLDSTPSLNRRQGQRVQRKKVVRKAPPPRGKSAKSAISQVTCSSEESSGEAEWEGFEREMMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0N4</accession>
    <name>A0A1E3J0N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05386</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030626.1">
        <property type="nucleotide sequence ID" value="XM_019177473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0N4"/>
    <dbReference type="GeneID" id="30194599"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="295"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN93521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="555" mass="60246" checksum="C11041680413511F" modified="2017-01-18" version="1">MARLTPPGQKPGTSGLRKKVKIFQQEHYTENFIQATFTAMPGGSQDKTIVVGGDGRYFSPEASQIILRLAAGNGIKHVIIGKDAILSTPAVSALIRSLKTDGGILLTASHNPGGPENDFGIKFNTANGGPAPEEVTNAIHKVADSITEYKQVDLPEFDLSKIGEFTHGPLKVTVVDPVENYIKLLKEIFDFDLIKNWLHTTSPKPTVLFDALNGVTGPYGRAIFVNELGLDENSIQNCVPLPDFGGSHPDPNLTYAHELVERVERENIEFGAASDGDGDRNMIYGKGAFVTPSDSVAIIADWAEKAIPYFKDGVKGLARSMPTSGAIDIVAKSKGLEVFEVPTGWKFFGNLMDAGRLSICGEESFGTGSDHIREKDGVWAVVAWLSILATANKETPGVGIKEVQLQFWKKYGRSFFSRYDYEECESEGAEKLVSHIRDTFAAPGFVGSSLKATSSDASFKVAEADDFSYTDPIDGSVSKNQGLYIKFADGSRVIFRLSGTGSSGATIRLYVEKYSQDESEYENDAQVGLKPLIEVALELSKLKEFTGREKPSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J357</accession>
    <name>A0A1E3J357_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031263.1">
        <property type="nucleotide sequence ID" value="XM_019176788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J357"/>
    <dbReference type="GeneID" id="30193887"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="468" mass="53318" checksum="C7955EC3B61C60F5" modified="2017-01-18" version="1">MIRNTLKGSHRQATPPLPSHSHSHLHRPQSNRPIILLALVLSALFGLSLLSHPDPSAGRKLQFPGLLPTKPPHPAHLKDQVLERAINQTYEAFKEACPGSSGIGVHLNPDLTASQKKRYEGLKGYGKGRYMLVTNTRQIEAHLPDLLNTLLVLLHYLSPEHIAVSILEGPSSDCTQKVIEDVLQPMLAEQGLGRSWMRIETGEHKIDWSQYNRIEKIAELRNRALEPLWEGVGDEEWSKEVEAVVFFNDVYLHAADVLEVLYQHQRNGAGITTALDWWKKRPEYYYDIWVGRTIDKGDLFYPIDWPWWSPSSDLFSSPTASTSKNAYTHLQPFQVFSSWNALAVLDRRPFLEHGVRFRRGDLEKGECAASECTLVASDFWKEGFGKIAVVPSVQLAYERDVAQDVLEDLNKQKAQIGWVDGVPPDHLDEKLEWRNHPPEKVRCHPWPETNGLSANVWENTEWVKPWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4E2</accession>
    <name>A0A1E3J4E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031110.1">
        <property type="nucleotide sequence ID" value="XM_019177078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4E2"/>
    <dbReference type="GeneID" id="30194192"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25195" checksum="A5F46DC3DDCC6BD8" modified="2017-01-18" version="1">MATFTTTGTVSSPLDLSKVQGEHANVSLSSNKKNVQPAVKVTLTSLTPHNSGTLRKINSVVIPIVYSDSFYKDMLDPNLDDANKLIYYADIPVGAICSKFDNLKKGSKEPPTLVILTLAILAPYRSLSLGTSLLRHALHAALHPPEPSAPAPSDKKTNTRAQLAKPETRPPVNRALVHVQVGNEGAKKFYERLGFKETGIEDNYYSKMEPRGAILMVCEDIAAAIGDASNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4H6</accession>
    <name>A0A1E3J4H6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD-repeat protein mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031433.1">
        <property type="nucleotide sequence ID" value="XM_019176505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193599"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002145">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="91"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1511" mass="167999" checksum="4D4F2F0A382A7DCA" modified="2017-01-18" version="1">MAYYGQHQGLQYARDEGSTSQLQSSYPAFPAEAYEHDEAFLDEHDEFPGEVDVGAALQYWTALRHMSPKGKQREETDEDKASKSPWRLRSKLKTVTAGLFICLNLGVDPPDVVKTNPCAKTECWIDPTQLPANKAIDAIGRNLHQQFETLNPKVKYKAFLDPSVEDTKKHCIGMRKTTKDERVVFYYNGHGVPRPTPSGEIWVFNKNYTQYIPVSLYDLQEWLGSPCIYIWECSAAGNILNNFMKSAERRDAEARHAASQAGHEELPRTSYTEALHLAACKVNQILPMSPDLPADLFTCCLTSPIETALRHFVLQDPLRRNTGLSADDPRSRITVDLAMRIPGDLKDRRTPLGELSWIFTAVTDTIAWLSFPREMFNKLFRQDLLVAALFRNFLLAQRIMQAYHCTPTSIPEIPDTHNHPLWESWDLAVDSCLAQLPGIFDQVGEPEPGKPYNIPAGMYKPSTFFAQHLQAFEVWLQHGATLNSKRAARGANGLVPRSPPEQLPIVLQVLLSQSHRLRALILISRFVDLGPWAVHLSLSIGIFPYVQKLLASPAIELKPVLIYIWARILAIDRSCQADLLRDSGFTYFTQILSAFPQQGSLVIPNANEHRAMSAFILSVLCRDFRQGQTACLNTHVLDACVQRLHEDDWLLKTWSLLCIGQLWAGFDEAKSVFWRMDRQQILIDSLRSTSVEVRAAALYAFGTLLGASALPPDSAGIGGGGTGSQIGLSDVQQLELEAGVAFACMMSVKEDASPLVRKELVVVISCVVREWRGWLVAAAWVYFEQEAALAAAESDQPLPRDVVSETLDQWTSDEDRHPAEHQHNLTLLSSFKVLFETLLDLSVDPHTGVALSASTVVDYIIALLVDSAFVRVEGSALRALIRKHSLPKPKPRVQSEKLSHLNGVPPPLNRQKSDTETDKSTGNIASLKRSSSVAHALRSLASITGLKTPDAPPEQEQLAQPHSEMPTVADLTASCYISPYPGATHQRIQPDKDSRASTPSRPAHQGNHLNSHMNTRSSLGILPSRLDQNPVKAYQVLEALTAEDMERLRMRRLKGREAGEDSDGRYGNNGLSLSTDLGLGMVAKEVKDDVLPLKSGYYDWAMDYFRTPQMKAPDADEPGSETYNEQAWKHQRNEMMVEKSRAGEEYAATHSWATEAGTLHNEAWPLQLAFHSYDPILAVTDDTDQVCIWDWQHGVKLNKFSNQNISGSSISSIHFVNEMASSLMLTASTEGSIRVFRDYDIPGQTALASTFRAVSDVYPVGHSSGVLTAWEQQKGHLLVGGDMKVVRLWDATVERHLRDISTQAGSNLTAISSDEPNGNVFVAGFGDGVVRLFDKRADKADEVVLRTWRQHKIWIQSVHLQKGSMRELVSGSMDGEVRVWDVRKPDEPLYTLPKRNSGLMGLAVHTGAPVLARTTAITPYSTKQELEITGFSNPVEPKRLARIAIPVPPAYNTRRHRPVDFLPSASSLVFHPVEMMVAAGGFDTSGTVKLYKCPTPDFPQGTQWEQANGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J5</accession>
    <name>A0A1E3J4J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031428.1">
        <property type="nucleotide sequence ID" value="XM_019176500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J5"/>
    <dbReference type="GeneID" id="30193594"/>
    <dbReference type="OrthoDB" id="2576255at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130127" description="DUF6987 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="221" mass="22624" checksum="C2E5DCDCC1AC2178" modified="2017-01-18" version="1">MRFSTLFAAAIPLLGSALAAPINAVGADALYLKRDIDVGADVAGALSLKRDLLDIDADAKAALNVRDVDYVSVLQNLESTVGSITTLAANATEDEVTEVLTTVNDALTTALSDLGLSSSSKRSERLVARDLTDDVSELLATVIQDVDTIVAPLEDTLSSIPAVKALLDEVNTALSSIVTGLDEILGGVLTLVSNILSGLGIDLTPLLSGVLGLLTGVLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4L9</accession>
    <name>A0A1E3J4L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031495.1">
        <property type="nucleotide sequence ID" value="XM_019176567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4L9"/>
    <dbReference type="GeneID" id="30193661"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11613" checksum="9E2137CB66745D44" modified="2017-01-18" version="1">MTTTTTFSSWNEVKANEGSNMDLRRVLPLLSFFTTSEIEEQLSSNTFLPLYLNDNCELPPIKFKITGGNVSVCDDDDAGDEESTNAKRNTYLQWRSRCLEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4M8</accession>
    <name>A0A1E3J4M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031474.1">
        <property type="nucleotide sequence ID" value="XM_019176546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4M8"/>
    <dbReference type="GeneID" id="30193640"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29201" checksum="2D36F354132B1C31" modified="2017-01-18" version="1">MRLFAIRIPDTPLDAAAFDKLATLVEPPARERIKRFRLPEDALRSLVARLTVTWYLHTQGLLAPRQLPVFGRKGKGKPTLSVPALQPRLEFNNTHEGSYILFATLVSSSPLACVGIDIMLHPEDPFPTQEGISEQLTLLERQSLAIPLTPRERSQRLTKLWSVKESYTKAIGEGITFGLERIEVELEGPGEGKVKTVRVDGKGVGERGWEWRQNDLGEDYGYAVWWRGDDAEDTGEPQMEHVSWEEFSGPLSDLADKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4T6</accession>
    <name>A0A1E3J4T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031543.1">
        <property type="nucleotide sequence ID" value="XM_019176615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4T6"/>
    <dbReference type="GeneID" id="30193710"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027240" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="543" mass="61405" checksum="51BB6A93D72F6D16" modified="2017-01-18" version="1">MWSKLVTTALLTLSLVDTLADARDPQGLRGRKPAALQAKKEAKREYMEREALKLEESRAYLEERDSDKRYYNNKTSEFFVDSLPDVPFDLGELYSGLIPINYSDTSRELFFVFQPKLGEASEDLTIWFNGGPGCSSLESFLQETGLWIWQPGTYEPVLNPYAWVNLTNMLWVEQPVGTGFSTGTPTATTQEETAQDFVKWFKNFEDTFGIKNYRIFVTGESYAGRYVPYVSAAMVDEQDKSYYNLSGALVYDPCIGEFDYVQEEIPTYPFVEANNNLFNFNASVMAELKGLHESCGYRQYIDDYLVFPPKGQQPHLFFNYSDPANATCGLFDIVNELALQINPCFDIYEINLMCPITWDVLGFPTELTYAPGGVYFNRSDVKAAIHAPDYVDWASCAAEPVFVGGDEGPQAEGDLSLDPIQYVLPKVIEATNRVLVSNGDYDMIIITNGTLLAIQNMTWNGELGFQSAPEEEIYIAIEDTQWSTVFAENGLSGPGEQGTMGVQHYERGLMWAQTFQSGHMQPQYQPRVAYRHLEWLLGFTEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J576</accession>
    <name>A0A1E3J576_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031460.1">
        <property type="nucleotide sequence ID" value="XM_019176532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J576"/>
    <dbReference type="GeneID" id="30193626"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="528" mass="58101" checksum="C7EB3CE7B7DE7E1A" modified="2017-01-18" version="1">MLQIMSKPSYVPRSRPASSSPAVPQTRSPAYVPRSASSSRAESAVTPKLPSQPLERKSSRLRYEMRPVRLSEEAQESAKSILKLLSSLPAPLPEELPPTFLPSPSASPVSSAGSPPRTFSEYVRAKRKRALESSDSEPELAGQVARSGAGVGLGLSVSPGQAKMRKTEDEGRNVTPLGSPSLLFAKKERVKSGLRNEVDVHEKRGGGEDARRDLWKREKWIEMSAWYRDRALLLKRHGDAYFRSPTAHKEYTSTLPADHLKGLLCLTDSALLYNYSHFCEEKAKGRPSPNTYDSSAGLRKFVCSKWEAEMRKEYKGEEGVHEKERAKAMAGLMYLLEAVIQYQTGRDALAMLQHRGKELQTTSTSPRDKTSPSASNTTASPNPPPPQPASVQGPSPASSHSPAHSPSSSTSSLPPDLLPLIFSSFRQNAESSQSLHLSRHHLTLRILRSSFPTTYQNAINSELADHALPAPGDALGSARYVDVDETDRFCWPIEIGMVSPVAHVVAFGRRMVQEMAEREGRDWSILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5R6</accession>
    <name>A0A1E3J5R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031271.1">
        <property type="nucleotide sequence ID" value="XM_019176796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5R6"/>
    <dbReference type="GeneID" id="30193895"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="498" mass="54734" checksum="631272B7BFEE6591" modified="2017-01-18" version="1">MSSTPPSSPWGPAVLPPTWTLSEWQQTTRSDPLVNWGRDDPIPEKVDIVVVGSGLAGAKTAHSLLTSYPAEARPSLITFEARETCSGASGRNAGHCRPDAFRGFTAFATMHGEKNAAGVLASEAITLDKVKAFVKEHSVECEFTERMTLDVVLSEEFKTYCSQAMQRAKDYGVDVSHIKYYEGEEAQKITRSPRALAAYEWPAASVNPAQLCYAIHRLNIALGAKLFSWTPVTSCISSSPTTLDKGEESEDGYRWKIMTPRGEVLTKKVVWATNGYTNLVLPEMDGLITAHKAIKLTLPPAGMAKFPRIEHTMSLRYVERFYSVMQRPDNSIILASPRKWPGQSPKTFQHLFGTYDDTQPLSERTTNTFFEVCDTLPGGGYTVVKDGGAEGYAKEGEGGLDYAWSGILGVTPDHVPFVGSVPDREGQYIIAGFNGHGMARIFHVAPCLARLIKGEKWDASVPECFEITEERLRRLREGLVEKAGAMGELTEKTGEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6A9</accession>
    <name>A0A1E3J6A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04108</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031640.1">
        <property type="nucleotide sequence ID" value="XM_019176230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6A9"/>
    <dbReference type="GeneID" id="30193321"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN96394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="479" mass="52109" checksum="99C4B5628D83B028" modified="2017-01-18" version="1">MCPPADAPIENADQEMVAIDTTTPHISDTSASNVNSTNGTAAAQPPPVKAHKGVYGRASDFLSNTSNWKIIESTLREGEQFANAFFSLETKIKIAKMLDEFGVEYIELTSPAASPESRAHCEAICNLGLKRTKILTHIRCHMDDARLAVETGVDGVDVVIGTSSFLREHSHGKDMTWITKKAIEVIEFVKSKGIEIRFSSEDSFRSELVDLLSIYRTVDKIGVNRVGVADTVGCADARQVYDLVRTLRGVVSCDIETHFHNDTGCAIANAYAALEAGATHVDTSILGIGERNGITPLGGLIARMMVADPDYVKSKYNLSMLRELENTVAEAVEIQVPFNNYITGFCAFTHKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVKDATAKIKELADVRTQSMEDVDMILRIYHTGIQNGDLKVGQSAVLDRLLEKHMPTTRDNSPSGKSVDTAGNPAKRARVGEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6B8</accession>
    <name>A0A1E3J6B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031650.1">
        <property type="nucleotide sequence ID" value="XM_019176240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6B8"/>
    <dbReference type="GeneID" id="30193331"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="40"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN96404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="477" mass="50746" checksum="04821191BAB39493" modified="2017-01-18" version="1">MSAINDPAAAAASGPSEPVQEVQVDVTKLTALSPEVISKQATINIGTIGHVAHGKSSTVRAISGVQTVRFKNELERNITIKLGYANAKAGLSIYRCQNPQCPPPSCFRSYPSSKEAHPKCERAGCEGRMELQRHVSFVDCPGHDILMATMLTGAAVMNGALLLIAGNESCPQPQTGEHLAALEIIGVDPKNIVILQNKMDLVRESEAMEHCESIKKFVEGTTARLAPIIPVSAQLKFNIDAVVAAICNIAPPNYDFSADPRMVVIRSFDVNKPGAGVDELKGGVAGGSILQGVFKVGQEVEIRPGLITRDANGVCTCRPLRSRVVSLHAEQNHLQFAVPGGLIGVGTLVDPALCRADRLLGMVMSSVGKGPSIYVEIRAEVFLLRRLLGVKTDDSKKAKVGKLIVGETLFVNIGASQTGGRITAVKGGDVSIALTTPACCEKGEKIALSRRIDKHWRLIGWGKVRSGGTLCEVVDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6E4</accession>
    <name>A0A1E3J6E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031658.1">
        <property type="nucleotide sequence ID" value="XM_019176248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6E4"/>
    <dbReference type="GeneID" id="30193339"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN96412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="45552" checksum="CE37A57BEC6040F8" modified="2017-01-18" version="1">MSLQQHLLDHSVHGPSFPSPPPSDRSTPELDPFTHSAALDPVDSPITDLVSPTSSVPDISHTHTHPATDDDDTAQALSNHHLQRYLHYKALAARAEADPALAACQHSDSAPTDDRIEDLLSSYMPDSAHSSLFSKDSIVSGNNMLACQQQRQQQQMPQSAYYQVGQSINTWQHPNTVFRFEPQPSQAVMHNAQAQAHLQAAEAARFQADEQRRVNMSTYYMAPQPAARFEQSSQGAMFPQQGITTGASASYANTPSYPGGANILMHKTPSMSGFTVASSSEEGEDELLYSSGAEDPKPMVPTIPVANAHGGGRGYVPGQTPDDPKKKHKCQICGRGFARAFNLKSHIQTHNPLRPKPYACPHNTCKRGFSRLHDLERHRQGIHSDGPLVEAKRHNVSPAIARAQTRMQERADSGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6H6</accession>
    <name>A0A1E3J6H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2A phosphatase-associated protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031704.1">
        <property type="nucleotide sequence ID" value="XM_019176294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6H6"/>
    <dbReference type="GeneID" id="30193385"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42875" checksum="2D78D5196BE6AEC6" modified="2017-01-18" version="1">MSDLPLPQLYAQTLTTLDPIFSDAVSLSAASTQSTLADALEKLHIIQRSLNLLGVYSDNEGWEELSEGALVFMTIGWVVGGCEEKRTGERKERVESLKRSEDACQQFVEVLTSYGIITPEEKAGFNLDGRTPSDPASRRDAKIQQYRKEKDMKERISAKVKRSGGSSHISFILALLPAPPRQSSGTSAFSLPDQGPEHEQDRHLILDVLRLLSVATYSALSSIKMELDILSSAHLEEIPSEPPRDPRQSGRGEEDTTWRLDALPGQNDPANLIAPGGKVLKPFTILPSASRETDRQKLKGEVFRQGWRLPTMTIDQYLQIEQERGGIISGGGQASYDAPTESETLELEAEMDGTVYAAEQAEKKRLKDENWAAYTDENQKGAGNTTNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7D0</accession>
    <name>A0A1E3J7D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031821.1">
        <property type="nucleotide sequence ID" value="XM_019176411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7D0"/>
    <dbReference type="GeneID" id="30193504"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN96575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="355" mass="37047" checksum="40C99DCD5CB4061B" modified="2017-01-18" version="1">MSSPIVVAIGNPLLDIQVNPDEGPAYLKKYDLKANDAILAEEKHMGIYDDIVANAKVTYVAGGAAQNAARAASYVLPPKSVAYIGSVGDDDLKQTLEKVNEAEGVQSAYQVQPTSKTGACAVILSGHDRSLCTTLRAAEEFTPSHLSTPEVAKLIDGAKYFYIGGFFLTHGVESALEIAKTAASKGKIVVLNLSAPFIPQFFKVQLEALLPHVDVLIGNESEAASYATATGMSDAPVKEIAAALAALPKTNSSRPRVVVITQGADSTLVASSSPSGSAGNLSLSDENPKTYPVSKLSDDQIVDTNGAGDMFAGGFLGALAQGKTLDESIEIGHKLGQMCVGQIGPKLVYPRVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8P8</accession>
    <name>A0A1E3J8P8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031702.1">
        <property type="nucleotide sequence ID" value="XM_019176292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8P8"/>
    <dbReference type="GeneID" id="30193383"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="170" mass="18562" checksum="F5067B605934AAA3" modified="2017-01-18" version="1">MPEATSSIPATSRRQQVPEEDATKLQFGEFADGEALTLTEVATLLVYARSVAGVPPVPDNKVYQSTSEYVNEFSSTSMEVSDAMRKYVRPPNSSIGICADVNLCSALTANIGFLNKFEIAQIMSLRPEKVEVAVALIPSLERYAQGDESEDQLQSLLDEVRGIVRYGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8T5</accession>
    <name>A0A1E3J8T5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031885.1">
        <property type="nucleotide sequence ID" value="XM_019175972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8T5"/>
    <dbReference type="GeneID" id="30193059"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN97283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="307" mass="33596" checksum="6FAB87958F157479" modified="2017-01-18" version="1">MNAVRQQIQQPSSLNSLAAAEDEFAHTDPAAWGSMAGFGNLSRTGGIESMSIPRVLDPTAFLDMHTDSMSANPEAKIKIAHGTTTLAFRFQGGIIVSVDSRATAGSYVASGTVKKVIEINKFLLGTMAGGAADCQYWETYLGMQCRLYELRNKERISVAAASKILSNIVYQYKGMGLSMGTMVCGWDKTGPRIFYVDDDGQRLTSDIFSVGSGSTFAYGVLDQASQAYGYRWDLTDEEAQELGRRSIVAAGHRDAFSGNTNNLYHVRENGWEFIGNYDINELWYEYEGKKKAAREAATEASPMVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J946</accession>
    <name>A0A1E3J946_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031707.1">
        <property type="nucleotide sequence ID" value="XM_019176297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J946"/>
    <dbReference type="GeneID" id="30193388"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="16419" checksum="9700BAB419B4768B" modified="2017-01-18" version="1">MSDWIPSSDPEFSMQCSALRKNGHVVIKGRPCKIIDMSTSKTGKHGHAKVHLVATDIFTGKKLEDISPSTHNMDVPNVTRREYQLLDIQDEFLNLMDADGNSKDDVKVPDTEIGQQIAADFEAGKDLMVTIIAAMDEELAISYKEAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9C8</accession>
    <name>A0A1E3J9C8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chlorophyll synthesis pathway protein BchC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032061.1">
        <property type="nucleotide sequence ID" value="XM_019176148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9C8"/>
    <dbReference type="GeneID" id="30193236"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="174"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="345" mass="37516" checksum="B13B887493D117D6" modified="2017-01-18" version="1">MVAQEMNALLYSEARKFSVTKVPVPEIGDNEVLLKVDICGVCGTDQHIHEGEFIAKFPLIPGHEAVGKVVSMGKNVTGFEIGDRVAADVGETCSHCHYCRKGTELFCENFSPAGVARDGGFADYIKYNFAKCYKIKNLSDEEATLLEPASCAIHGMDKLQMPFGAKVLLIGAGPTGLILAQLMRLGGASHVTIAANKGLKMDLARKVDAADSYIDLDRNDAANQWAQIKKDNPYGFDVVAECTGVESIVNDAINYVTRGGTLLVYGVYADKARVPDWSPTDIFVNEKRIIGSFSQTYCFPRAIDLLDSGKIRTTGMVTDVFKLADYQAALDKMASRQALKIAIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JB46</accession>
    <name>A0A1E3JB46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031938.1">
        <property type="nucleotide sequence ID" value="XM_019176025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JB46"/>
    <dbReference type="GeneID" id="30193112"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000077">
        <property type="entry name" value="GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="568"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="769" mass="84405" checksum="B220632F4E871059" modified="2017-01-18" version="1">MEYQEDYVDVKRPRDGDDLYHPKQYSSDQAQSSNYQQISPDTTSSVLSTAPLSQIKSSTSADRRMSVGMGQPGGYTGMAQVAQSQGPRGDEAVPVGFDEAVLRGLCDMDCSLSLLADRIKQGIVSCKQVATFFRSRADVEEKYSRSLTELYRSTGDLYARGDCKAGTFVQAYNSGLRLQDQLAQNRLRFAQRLNEMAEELFSLAREGEKTRKIHKETGSRYQLIIQDAEIAVEKAKTRLDGIVEELDRVLAAKEGETYKDTRGGYNTVGGPAYGNNGSAPSASAPSGHGKSKLGKAMKTGGLLFKGKGSGSLQKQEDDSRAKMDHANETFTKAVAESKQLRKEYFSFQLPKILRLLKECADEIDLGTQYHLTRFAFLYETMTVGDGAVLNPLGNPEEGPGLKAIFESIDNRTDFKSYMQNYAVVRGTPRGPRREGPYDDGFQMPLPPHVQRSQDSTFSASQSSAHTSPQPQALPSPHSQASGYGYQTSPQPPSASQMQSSAPPPHPSGPSHNYNPSIGSTITTQTNNTLPTNSSTTQNQGGETTSLASYQQDYMAPGIPASTGHTFGVDLGEQLARDGTAVPRIVEKCAVAIEMYGLESTGVYRLSGTSSRVQALKAALDNDVNAVDVESDEWSADINVVCGALKLWFRELPEPLLTHGLYHSFIEAARYENDRLRHIRLHEQVNELPDPNYATLKFFMAHLDKIRRHESVNQMSVSNLSIVFGPTLLGAPPEEGGLNLEHMSFQCKAIETILNKYQEIFVEEDDDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBZ2</accession>
    <name>A0A1E3JBZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032262.1">
        <property type="nucleotide sequence ID" value="XM_019175772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBZ2"/>
    <dbReference type="GeneID" id="30192857"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33304" checksum="A6AC71100281AD3B" modified="2017-01-18" version="1">MFKKRSRPASVRDKPRTEDVEEGQASGSATPAGEDEDNGHTVEELILLRKLKKSQTHQGIDLEKLNRGADPADRAKAARSKTEQDIKGADAYGIQKGGLSGGGGGDKDDDLADETEKVKRLVRANNFTGQTNALDVDKHMTAFIENELAKRRGQAAATTSENPEPYDPQAELYKIAEKYQQLETSKKKKVDDDEGNVTNSLGMLTSIPEVDLGMDNRLRNIEETEKAKRAMMELRKQEAAAAAAAAREAEDPGYAAARFYRPNQRVASDLYTSSSFDNKPHVSNRPETATDEQVYERFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCS3</accession>
    <name>A0A1E3JCS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032347.1">
        <property type="nucleotide sequence ID" value="XM_019175857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCS3"/>
    <dbReference type="GeneID" id="30192943"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="102101" checksum="91F2474C911D9CB6" modified="2017-01-18" version="1">MASYFPSFTAPSPMALAAASTNLDDPHLEVTVTPSASAFYAGETFSATITIRNTRTPSHDAKVPETPLTVPPTAEVSTATSQTRPLPPVDARHPSDAPQLPRRLKQIGAGLSDIPLNGKKFAENAEAGPSGARTPMRIQATPRSPDLDSGYPYSPGANTTFRAPGPSSPQREGLMNFRSPEGWGGKENTMSKELGHQRRARSLALGKGAMSPQELVWALGGQKTAPPPLPSRRSRDTQIPAHHPHSRKISIANPITAETSGQSEDNTPPPLESIIEGQASPSGRPRSSTRPSASRSNSQNDLKQGDRSVSQVSPNRLRRPSHNRTPSYQNAYGASFMGIHIDTLPPPPSHPFIREREPRGTTTVLWAYTRLVGHFHPSNTYIPPDPLLPLRAILLHQPVGSGSLLTPGGSSVSNPAGKSSSSSRWQLSFGTGAIGNATQPSLTGSLFGLAKELITGGGGGSLEEERRRVWNMKDLPVLESTRSLMGVDIRLKEGESRDFVYTMPLPTVLPPAHRGKAFRFSYDLVISLSASLPGGGHRQKSKDIVVPIRIWANVSVGHPYRTYDVLHPVIQTKEEGNVQNLEQPDMPSLPASSTPQSQEMRRQSSASDRHRIKNGDTRDSLQAYASHLVDTLKPNGESLQPMSPSKRDARSRAASPSSPVFRIPATDQIEENTDLFVEGDEELLDEVGHEGGCGEAVEILSRHSPKASYDINKDGHPVSVMTLAKTTYRLGESVLGIVTFNHPTSIFRVLKFSAYLTSHELIPEPLLPPPVHAGGPEQPNLQTVHAEYHTAYALSAERLAFLLDIPSDATPAFSLAAGEGDKGGLEWRIKLKFTVGVPAHGVPKSHRRSVDHSRKSVDGHAPVSEAVNLIPTKRHRSGDEADNAFYSALQSLNPVIPVSQAYRDAVGPDGGAEWSEMRTEMVECEVPVKVLAGNTAFLVRPAVFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JDT5</accession>
    <name>A0A1E3JDT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032128.1">
        <property type="nucleotide sequence ID" value="XM_019175638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JDT5"/>
    <dbReference type="GeneID" id="30192722"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130280" evidence="2">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="14409" checksum="7D54A923FF5852E4" modified="2017-01-18" version="1">MRFATAFAVLAAVAASNCRRCPHRPAASLSVSGPPPSGTGAPPPPPSGAPQQRRANNAAPAGQESASLSFSGPPPSGSAPAGPPPSGAPQQKRQDAPSGSSPAGPPPSGAPQQKRQDAPSGSAPAGLPPSGSAPAGPPPSGAAQSGGPISQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEW5</accession>
    <name>A0A1E3JEW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032461.1">
        <property type="nucleotide sequence ID" value="XM_019175358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEW5"/>
    <dbReference type="GeneID" id="30192439"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="86" mass="9286" checksum="D437BC831C6E8BC2" modified="2017-01-18" version="1">MTPALRQHYIDTATRGSSSSTQQISDIQSQASQVDSRQTQQAAQSKSARKRKSRSSADATAGRAARTEDAQGKTVPMADCDEEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF78</accession>
    <name>A0A1E3JF78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Condensin complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032610.1">
        <property type="nucleotide sequence ID" value="XM_019175507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF78"/>
    <dbReference type="GeneID" id="30192590"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="562"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="923"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="933"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117452" checksum="5898F245DE1357F6" modified="2017-01-18" version="1">MVNAKPKKSKPSVGPEYLTDTLPSLLPPIFEQVQQTTANHRKNIVHLHKIQEQCAIFTEETAKGIKLVGEKAFNTAFMDMVSRVLPVKKGVAVADRVIKFVASYVIYSTETGYFVDAENKPEDEDDDEDTDTTASRFVGKLLRHLLSGMEAKDKNVRFRVTLLTVSMISGLGEMDDDLYVLLRKSLLDRAKDKEAAVRVQATLGLSKLQSGEDEDDLEEGQEPLANVLLDILRYDPAAEVRRAALYNFPQTPATLPHILARTRDVDPILRRTVFAGVLGADGLPDPRVLSIAQRESVVRNGLGDREGSVRKAAAGMLAGWLDTVEGDIIEFLNRFDVVSSQVAEDALVSVFVTRPEVFQAVDFGDDFWTSLSPEKAFLARVFVDRCITTKDNIRLEDALPVVTALAFQIQDEYNKLVSSTNDDSEESDTGDRTFVVGELLKLAVNLDYADEIGRRKMFQLAREMISQSNLPESLIPLCLDVLSKIANGERDLIRVVVDVVTELREGEGDEEDGPSFGQGSAGDNSISVRRLSVGSGRSRSVAPRFNMDDPEDRMRAALVDLRCLLICISLLERVNSTLQDNSVFHGLLPDLIIPAVRNKEEPALRDQGLICLGLCCMIDAKMAANSFGLFIQQLQTADDELKVKVCQVIFDLLMVHDIDALISKTMVQRDNVVELVRHTLSLDIPEVQAVACEGVAKLMLAGMISDVVVLQSLVLLYFSPETAENQPLRQCLTYFLPVYCYTAAENQRRMLDIFYHTFGMLSRLWEEAEDEEMPPLSQIGLMMVDWLDPYKAVEKDGSSVDTAIHLELAAEILKCLLTETLPESRKALASFLSKLSLPEEASETWRLKSLLALITAIRDKRPLSDAPSRNAVNKFEIGLLKKWSDVLGDFDGDTFRSEAERNGEIGDLYGFIDEVDEIDVAQNEAGTRKGKRGASTSRRSRSVSTATRDETSEEGDDQSTVTGGSDDDDDATPRATPQTKGKGKSSKASASKVKAKEPPKPRSSRAKKASAASVKKGKGRMAPVEEENEEQEDEEDDDDEDEDEDEDSEVESILDEDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFG4</accession>
    <name>A0A1E3JFG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032649.1">
        <property type="nucleotide sequence ID" value="XM_019175546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFG4"/>
    <dbReference type="GeneID" id="30192629"/>
    <dbReference type="OrthoDB" id="2591172at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="710" mass="77222" checksum="ECA2DB2274BB84DE" modified="2017-01-18" version="1">MSSLVQSQSFDGDRGQAQQNLYSSPAGSPRVSRPPSQASIHVPQQPSYSPHLPAESPMPVSAYPTYRPFADGLTLPPIPMNGTGIYPNSAPMTYFPAIYDGRSSQPMIRTISHAHPMNSATEQTESSRYSSSPHSANGQLVDAPPTAGAPSGPWGQPSFSLPDDARLNSMFASNGYSMSRSTSGTSEGPETRLLTPHMDYRTSPAEADMRQVNDSLAGKKYYPQLASFTPRFDLQNHALGLGPHPQPDAFFGNKSYGAGSGAAFSLSEKRGGESEPVGETEYERDRREQIMSNKKLLDDVGLGSSLSFGSKHVSGGSSGTSTPKRKASTPVKKRLHLEGPGEYQMRASPRIRSMNRSISYANLDGGSGSDDNYGSSDPEQEQDDEEEEFRPTKRSRGGNGYRQKSASYSSNTSSKAAKPQLSLWGLLQVYSSIPHNFPLFYYTLNNDLTINSDSVPLIGSIPSNCSPVAKAETLAAFFHRGRRVLAQLDAFTTRCDRKYEGPENKWPELDYHTRIAVRDVRRKIVERCENYKYTRRDILDKHLGRGKWQPIEDGMIEWRVGMTVNDPANDLANVTLTLPTPPPDAYAQSMRQTAPPPIYTDRAIKPYPHGRRIASAAPRNVSVVMGEPDEHAYPSAAGSSAMYGYAAPPANMYGEDQVPLSVQMPGSASSAAARAASMEETANAAGWNRGAKRGRSSSEESDACSAESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFR0</accession>
    <name>A0A1E3JFR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032582.1">
        <property type="nucleotide sequence ID" value="XM_019175479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFR0"/>
    <dbReference type="GeneID" id="30192562"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="358"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN99505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="709" mass="76424" checksum="82B7A59989CAAD8A" modified="2017-01-18" version="1">MSEQIKRVFADKKEQDQAAFVTFLTAGFPQRDSTVPLMLALEAGGADIIELGMPFSDPVADGPVIQKANTVAINNHVSYADCLEYVRQARDQGLKAPVLLMGYYNPLIAYGEEKAVQDALSAGANGYIIVDLPPEEAIKFRNICTSSGVSYIPLIAPSTSIDRVKFLTSIADSFIYVVSKMGVTGSSSGEAISASLPELVKRIQTFTPIPLAVGFGVDNRTHFDFVTSAGADAVVVGSKIIKLVFDHATDGQAAKEVEAFCREITLKDQNPPALNRKSALSSAPAPPLPIPSSTPLAEAETRVTAPGKLPSRFGLFGGAYVAESLVDCLAELEDAYVKAKDDPEFWKEFESMYGYMNRPSELYLAERLTEEMGGAKIWLKREDLNHTGSHKINNAVGQILLAKRLGKKRIIAETGAGQHGVATATVCAKFGMQCDIYMGAEDVRRQELNVFRIKMLGGNVIPVTSGTQTLKDAVNEAMRDWVTRLDSTHYLIGSAIGPHPFPTIVRDFQRVIGREIKSQLYEKTGKLPDAVVACVGGGSNAIGTFFDFIEDESVRLVGVEAGGEGIDTERHSATLTKGVMGVVHGAASYIIQSADGQLVPTHSISAGLDYNSVGPEHSHLKHIGRAEYVVADDIQCLTAFKMCTQLEGIIPALESSHGLWGGFQLAKSLPKDQDVVICLSGNGAKDVAEVLLTLKKKEYADKLDWHVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHN8</accession>
    <name>A0A1E3JHN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03450</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032683.1">
        <property type="nucleotide sequence ID" value="XM_019175580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHN8"/>
    <dbReference type="GeneID" id="30192663"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001094">
        <property type="entry name" value="RIO kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="353"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN99606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="528" mass="59926" checksum="1A8F57DF1E51585A" modified="2017-01-18" version="1">MRLDATDLRYISADEFRVLTAVEMGSKNHEVVPSKLVAELSQIRGGNVKKSLGELAKRNLVARVQNVHYDGYRLTYGGLDYLSLRTFSRRKLPSVHSVGSKIGVGKESDIYVVASEEGEKRVLKLHRLGRISFRAIKSKRDYLGKRKSASWMYMSRLSAQKEFAFMKALYDHGFPVPTPIDQARHCVVMSLIDGYPLRSIEQVDDPAELFSKLMELIMRLAQAGLIHGDFNEFNIMLLRKTGEPIVIDFPQMVSTRHENAEYFFQRDVNCVRRFFKRRFRYEALSWPTWKDVLETEEEIEQPQPAAGEVEGDAESQAVESQPKRVRIDLEVEASGFGRAMQRELEDYMIEVQDIPLSDEEDEDDDSEDEDEDEGEDEDEEGEKAVDEGMKDEEPLDEAAMAARLEALRLHRALGNDSSGEEATDSDHSLTDPSSESDSEDSDDSVGPARTDYTSYTPSARNTRRHHERISASKLGDRQAGKDAVAQQVERERKLVERRSQKSGAKVGNMKGHKWKSNAKYLVGKDSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIA0</accession>
    <name>A0A1E3JIA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032803.1">
        <property type="nucleotide sequence ID" value="XM_019175071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192144"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="746"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1295" mass="141686" checksum="E14873E2D7C2912B" modified="2017-01-18" version="1">MFKQKAPSLPQETDFTRNLRETSFYRYGHLRSLGLTGEVTALAIDPVLSLFAIGTSTGFVHCYGSAPFQFTLPVSTASSSSPAKPIRFLYFHPGHHRLIAIDDGNTISTYSLQHMTDSPNPLTHPTLPLKETSYTLWGTVTSVDQPLPSHTHLFLTVKDGTTLTWDLSRRGLGNWKIGNCWQDYEERMIRSGIPGRNKTLGGPMATCIAMSPRDLNIILIGYEGGVVAWDMQQHAVANTFEMILPPGSPGGGSYQDADGSLWTERTPSVTCITWRPDGLVFAVGHSDGCIALWAYSESDKPLMVRTITHEDVNVTDAESLLDAGALPNQIRQNVERDQHGNRVVPAISANRRVVPAISANREPIFKMTWAGFPDQPSLKALIAAQGTPQAGEPLTNATVEYAERGETLLMVLGGQSPGEKPGINILQFPAYKPPIVNPKNPHAESMPVQERYAFRDSLSPSGSSVWLTSTPPEDFVLLPRSSPYFNLSHDPISIIISLTPDPSVPELKAPHAARTIEAWTFPPPRSNVVPPPLGRRTYVQPGEGERAVAMTPAPVLSPTPGTPTGSGWKLPWYKRASSSSTSIPAVSTPDSTLSGSIARASLNRRQQALPSSVWSGTLSVLGTELCSLSTPAFKRLISWTIEHSGEEIAPRLPIHGGMAVPDLQSHGAPEVMVAKMESYRIMMTWHADCTVRFWDVSPHILILPTPLRFEYPNPLPHLTINIGDWLKHPDVAHLPLAQLWCNDRSKVQIKSVNLAREALECVITFTTGELLVTKFQKASLPLNPSDDGYEPDFEYRRSYEGGEGYNEEEREYFPPQSKQGDSGWVEEVLEIGQLSKGKVDGFNPLAIFTMKQGDPVSVALSDIGFIAVAFSSKSLAIIDMRGPDVILREGFDEEGTVMKKKKKKGNTQNVLPESSVVGSMKWVVSMMGTDTVNRPRLIVSYAKGLNKIYALINVLGEWLVEPKPPTFTNDSLAHPLASFVLDPLTGAELVTSAEALQVAMRDSENQQHIAQSKGKEAVVHCIWVAASRKSIRCALNYNGERISKVEMTDAEELSDVFYITRHGNKIIAGVTTTGMAHFYSVPNLQPITSMPLYYGTSPRSTGRLSIDDRSGDFIEYSGPLDINLRTFFQFRKPFPPRLDPCAHKKAIPPQPLPVTTGLIGWLWGAALTGPQLDALIGGPARPPPPREPPAPTKPLISWGKPPTEEAPRTPTSATSVPTRKSVAKTKGPARDVREREDVYSEMRNAAYMRDGMLDTLGDSLQSVSGAAGQYLSQAKNSALKEGAKMTAKGMFGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJK1</accession>
    <name>A0A1E3JJK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoplast regeneration and killer toxin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033008.1">
        <property type="nucleotide sequence ID" value="XM_019175276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJK1"/>
    <dbReference type="GeneID" id="30192356"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="499" mass="54691" checksum="B63F4DE72B9DA64C" modified="2017-01-18" version="1">MAATATNAQLYQQSHMDQQIQMPVPNLNHSLPPVPPQQQQSPVQQTHYQQPPQPASLYEEGVSSDLADDRQSRYASQPAPLLDQSHLRPGNQANLLSHDRTLELYRSNAKKTNDPELIFEFAVFMIDAAKGMVSPAQEADPAPSPQVTKQLEKREEILKEATQLLKKLADRGFSDAQYFLADCFANGVGTVRGRQDFDRAFPLFILAAKHGHPDACYRAGTCCEHGWGCRRESAKAVTFYKRVYVSPAVGLHPGAMYRLGTAELNGSLGLARRPKEGVKWLKRSAEHANEEFPHALHELALLHERGIENVVFVDNDYAAELLSKAAELGYAPSAFKLGECYEYGKMGCPTDPALSIHYYNIAAQQDHKDACFALTSWYLMGSPGVLPQSDTEAYLWAKKAAELGLAKAQYAFGYFTETGLGTDANPAAAQTWYKQAAEGGDKRAAKRLAAGGGSRSAALDRRLEMEALKEERSLLSHSANSGSKSGGGKDKDKDGCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKP5</accession>
    <name>A0A1E3JKP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032879.1">
        <property type="nucleotide sequence ID" value="XM_019175147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKP5"/>
    <dbReference type="GeneID" id="30192226"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="150"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="825" mass="93636" checksum="309CA7E7C0708825" modified="2017-01-18" version="1">MSADAEEPKHAVPIEDPNALNSLSKFTLFRTKTRLYITASTGDIHRVLKIDRTDPTLLNVVEDTTVYDSNELQTLLRMVKDGNKSQGGMDLVMDFHGLVGFVKFTAGWYLILMTERSEVGLLGGHYIYHCDETMLWPVGPRIEKRLISTFNMVDLSKNFYFSYSYDLTNTLQTNLTVAAANRRWNTRFMWNHHLLSPAFDLEEPRGKSRWIIPLIHGFVDQAKINVFSRTLYLTLIARRSRHYAGARFLTRGANEEGHVANEVETEQIVSEPLSTAFGQTDPESPTVPVSEFSSGYGGYTSFVQYRGSIPVMWHQESNQMTPRPPIEITVKDPFYTPAAKHFDDLLGRYGAPIYILNLIKARESVPRESKLLKEYGECIRYLNQFLPEGKKMEYIAWDMSQAAKSGQQDVIGVLEDICEESLQATKFFHGGPARNAAGAAAHRTRPLLQHGILRVNCVDCLDRTNAAQFAIAKRAFGQQLYALGFLSTPYLEFSCDAVDVLTEMYHDHGDTLAWQYTGSALVNRVDTYRRIKATQWSSHSRDLLENIRRFYNNSMLDGDKQAAINLFLGVHPSVPKYNPTRPNYQKWFNPNSLEEPKADKLAPINQVYTEYYKTNKLSDFNDMYAFNMNSTMRFHAKPRHEQFASPFEPREHAAHHNVPPPRRTARRWATPAETPGSPHDDLSPRLPKPTTAKIVSDEPPSALALFIQALYDPPDMDVRVANYDFYAHYAESEGLDMIVEDQDMTLYRSMAKVGEGGDVDKLLGGMAGSLKQRMSEPPKESADMAMDNEQRIWRDNGATKDAQALERFTGLVSVPFQGGEYVFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLW6</accession>
    <name>A0A1E3JLW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033055.1">
        <property type="nucleotide sequence ID" value="XM_019174676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLW6"/>
    <dbReference type="GeneID" id="30191741"/>
    <dbReference type="OrthoDB" id="10289856at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40635" checksum="6DABA7C1378C8CC0" modified="2017-01-18" version="1">MARITRPLISLSPLDPDIRLFLFETYVDSLSVPSSAFCDVLLLSRDIHDKYLPRLYSSIFLGAERSQKFCIASATALKKPFVLYNEIYPSPSHYGDQRVLYPFDPRPTRRKPFTLVRKLIIEDTVGLEKLEYLQCIVKDHVMANKKLPMLGASIRLFPGLRWLVFPQGASDIPPGRPGDLRKLLQYELFSSSLAPSHICLTTPNADESDWIISALRVYMRQSSHVYNTLCLHGYRGYRMMTMGVNRMENLRIWMDEPWDESDRRRMAEEHAEEIWWLVACMAESEQRSDWVLPLPLKTIEIYGSFASQSTVEDRIRASFSPEPAWLGGLEVHGYGEVDAVCEGCGMGARSRWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMR6</accession>
    <name>A0A1E3JMR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033355.1">
        <property type="nucleotide sequence ID" value="XM_019174976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMR6"/>
    <dbReference type="GeneID" id="30192047"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130459" description="Synaptobrevin homolog YKT6" evidence="11">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO02103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25034" checksum="9D9C6EF0FF447377" modified="2017-01-18" version="1">MKVFAISLLSVTPTAPAQATLLGTANDLSSFSFYQRSSVGEFMSFFTKTVAERTPPNQPSSVEENNYKAHVFVTTGRTPGSPGLAAVMITDLEYPLRPAFSLLTKILDEHTPLLAHVPNASAAPSFGSASANAFGGNPSTAAAGGLPPAQKGKLEGTLAMYLTKYQDPKQADTIMKVQKELDETKIVLHKTIESVLERGEKLDNLVERSNALSAQSKMFYKTAKKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF5</accession>
    <name>A0A1E3JWF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033721.1">
        <property type="nucleotide sequence ID" value="XM_019173914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF5"/>
    <dbReference type="GeneID" id="30190966"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="30083" checksum="88CBDF1D208550E1" modified="2017-01-18" version="1">MPAAATLTIPQTPSRSRSASQPNVASIPEDAALDTTPRRLAARSATVRSHSSNNVRAPNPFQPSPNADSPSLRASKGRARSSSLVTVTEVGGDDPDNVVDRLGAGNNENAAWVNAPGAWLIHPVLICCGKLLIDAIPGMTHDVSWTIVNLSYITFSFIMFHHVTGLPFESTMSTSGAYDDLTLWEQIDSGAQYTPAKKWLTSVPILLFLISTHYTRYDYVLFALNFAALIFVLFPKLPILHRLRFHFTVNNATDIPSTPNPSRPPSPSIHRSITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWS7</accession>
    <name>A0A1E3JWS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033976.1">
        <property type="nucleotide sequence ID" value="XM_019174169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWS7"/>
    <dbReference type="GeneID" id="30191226"/>
    <dbReference type="OrthoDB" id="10279040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="15589" checksum="F3B491F8A68E934E" modified="2017-01-18" version="1">MNAEEAELLKQEELVQLILQDWRMWWDADERLNYGEVAIRLLFWWDKPDSLGNRYYWQSTRYVFDHETRFRDILEEFIGEYMSHVQGDPRPEEFDLDWSGYESFLSLHLSPSHYIHMVPFATIVIDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWY4</accession>
    <name>A0A1E3JWY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCY1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034029.1">
        <property type="nucleotide sequence ID" value="XM_019174222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWY4"/>
    <dbReference type="GeneID" id="30191280"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="935" mass="99406" checksum="5E310869222A401D" modified="2017-01-18" version="1">MNYLKSITSSVLQSTGVTFPFSIGERIAGVDSYSSIWDVREGVKRDDGTPLTLFVFDSTLPPLNGKDRKTLFHLAKNALKKLRTIRHPDIIKYIDSIETETHVYIATERVRPLAAVLRDWDTGGALATGSGASRAKGKEEWIGWGVKSISTAVAFLNTAPLSLHHSYILPSSIFVTPALEWRLSGFELLTNKDDGNGVLWSYGGFAPGDLGERAPPEVKKGGWGALRDTDPAQHDIYYLATLLFSLYNPNSPLPPLSSQPTPTSSGNIPRSLFPLWKRMLNPNARTRLSTAGFVEELEGAGFLESNSLVSVMKGLDNFELLSESEKLSLLRVIKDSSSSLPIPFQTYRVLPSLLHSLSLPSAPSSAMLPLVLSLGKGVPGQEYGKMVLEPVVRLYQSPDRGTRMALLEGLDKYIEKLDKPTVTEKIWPHLITGFADTVPVLREATVKAIYPLSSKLSDRVLNNDLLRLLAKTQADPEPSIRTNTCILLGRLAPSLGYNTKKKVLVPAFSRSLRDTFVHARVAGLMAFMASVDIWEKEDLAGRVLPGVCFCLVDKEKLVRDQAFKAVDMFMAKITSIAESMPKSSNPDGHAAYPPVTSLSSNSTLPTSSANTVSTASSAAGALAGWALTGLSKGLSKGEEHAEIQSGGGGGMPGGFGLGAPQGSGSGGFGSTGTSQAPSAVASQTASPRGSDEIFRPPQSTISIGGMKMKPKAKPTKPSASSSKPGLKLGGVTKKPQAKQKSLADQLAEEYEDDDDDGMNAWGNDDLMDVNADQDDWSAFESAPVPEVVVPPPQDYYVKPTPKAKPAPKSTPAPAAKPEPIPVPSPVPPPAPLLAPAVSASPTPPSPPTTLAPKPIKPTPSPIAAQTPILTSSPALSQVSAMAKSPAPSFSSELSAGTATGGGGLAGMSKEEKEKEMARRREERKAKIAAMKKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX09</accession>
    <name>A0A1E3JX09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034044.1">
        <property type="nucleotide sequence ID" value="XM_019174237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX09"/>
    <dbReference type="GeneID" id="30191295"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="64133" checksum="EB022C1C8CE940E1" modified="2017-01-18" version="1">MNITLDDTSPQFRYFSSGNTWIANHTTDPSTDLYFKKTFMGTHTEADYVSLTFNGTAITIYGAKRPNHGVYSTQLDGGSESFQSGYSSTSQFQVPIFQAMSLSEDLEHTILLKNLPSQTTVSGTNNTEWWMDVDYAVITTSATGKVWTTTYDDQSPALNYIGSGWDPYAAPLQPADYFNRTAHVTQTVGDSVSLSFNGSSVQVFGGLYFDHGNFSVSLDGGKTSNYNGTFFELQPGTTLYQATGLEEGVHNIQITNLGQGRKGKFLDIDYFVVNSTVDHSSSDNSTDGNSTSTSTAVPLSGKSSSNAGAIAGGVVGGILGLALVVVLAWFLFRRNRTKLGGEESPYLKPGKLDFPMDLNGTEVKPYISNQQEHHILPIGALPVHNDPPTSSYNGHVRELSSNTTTGHSVHQLSPTGRDTNARGSFLNVVPGPPPSNATSYARSINPPSSIGSPPPIPEGYTNPFNTPREQGMARSEGAQTFGVGGGTSDDGHSRGSGKSAGVPLPYTARLPSSRSPTSVNTATASIPPVPASHQASSPGADISNPHGEGDGLRSQGSIGRMYVPGRAQDVGPFGAGAEVEPEVAAVLPPDYNQATEPLPGQRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX64</accession>
    <name>A0A1E3JX64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin. Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine. Plays an important role in virulence. Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034104.1">
        <property type="nucleotide sequence ID" value="XM_019174297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX64"/>
    <dbReference type="GeneID" id="30191355"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13904">
        <property type="entry name" value="CuRO_3_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130604" description="Laccase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="206"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="452"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="64824" checksum="742E8478F14E57A7" modified="2017-01-18" version="1">MRPHFLSLLTLLGGVSSAYATICLTRLLVKRLTTPLRSPKAENLTRRATTTTTNTTSYVLSNDFDITATPTTREFTWEVATATASPDGFEREVYTINGQFPGPLIEANTGDTIRVTVTNSMDKGQTIHWHGMFQASTPFMDGVPGISQCPIPAGSSFTYEFVVNDQWGTYWYHSHYSVTMADGITGPIVIHSPDEALVRGTDYDEDRVVFVTDWMHDESQTIVDALLSADGYKGSFNPPQGDSTLINGIGNFSLSDTIPSPAEIQVPVDSTVRLRFINIASCTMIRMSIDNHDLEVIEADGTDIYGPTLHEVAIAPAERYSVLINTTQGAEGDAFWIRATSAVFCGLTNDQVGKAILRYTDSSGNLTTSEPTSSAWSDLATSTDECTPLDVAYTLTPRQAQTAASTALSTQVLSSQVGAFVDVNNVSFAGFAFNNTMYQNQIYNPLLSVVHNGDTINSSLIPSITFKDNGAANIILNNLDTVIDHPYHLHGNAFQILARGSGTMSADGVDALTLSLDNPLRKDIVWIERSSWALIRITSDNPGVWPLHCHIDWHLAVGKMAAVVVQPDAIRAMDLPSSWSDVSDILRKLTIHKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG1</accession>
    <name>A0A1E3JZG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033947.1">
        <property type="nucleotide sequence ID" value="XM_019174140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG1"/>
    <dbReference type="GeneID" id="30191197"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="13499" checksum="22E12490326B72B3" modified="2017-01-18" version="1">MLNDPARGLSPQLTTNALDAIHHTLNAISAPAAPEPARRHAHEHEYIAPAPRPDNEHPQPPRYVAFRPLHPPASQKGILQASLARPVPLCIPFTTIRIPVILVITGPDSSFHPSGPALYPNSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZH9</accession>
    <name>A0A1E3JZH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha 1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034285.1">
        <property type="nucleotide sequence ID" value="XM_019173580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZH9"/>
    <dbReference type="GeneID" id="30190630"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="481" mass="54666" checksum="D80DD3BD095FD833" modified="2017-01-18" version="1">MPPVASWFDYFQSGKYNLLPTNASPLTTSLSPEMTTRAYLGKRRRLFQLCAMAVIGMLVLGGIMRHTGLPSPADRASSSLDEGAQDDREREMWGKTEQMGWQSPESEGLVDLGEVAEGRFRLNIKPEESSVAEYYRRLYDFAVSLPMGLHSPFLSSLYAHLPPSHPDLVPDYPNAQSYLPSMISYKSIHMTDKTFNPSNELIQTWQRVNERDGWKLNFLDDSAAAQWVAKVFKRSDVEWAWNFMHRGVLKADFLRYLLPLVEGGVYSDVDTRPIRPVEQWGTTNPEILDLSESDGPNWRSQLSTHPSVIVAIDVDVHAFVNWQNSWPRPLGICQWTLSSAPNHPIFLDAVRRVVNASHVVEDWEKWREGEIERLELEKADGWEKAVEDLKKQMRDHAMNVMEWTGPGLFTDSVLAFLLARYNVTWHRLRGLHHPLRIGDVLILPITGFSPGGQKDFRAEGPDSPQANVLHNFRGSWKGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZY4</accession>
    <name>A0A1E3JZY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium activated cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034466.1">
        <property type="nucleotide sequence ID" value="XM_019173761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZY4"/>
    <dbReference type="GeneID" id="30190811"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="296"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="70841" checksum="E5D7B631EE8C6760" modified="2017-01-18" version="1">MGDALAVEEQRSLMSARSLTPEPVLLTQSRSELVKRCRAMIIKLLPVEVEPSQITDATSSIITPEVIAAFAKCGGDFGETIPFALLRAQTNFISEAYKNPADYDENTCRGLAAEVLARRIVHNLPTDRLESVMSTRYRYRESDGDVSAPTSALETAIDQHCTDFLSSSEAQHVVNSLWRGDWVQRNNDDMDIDYVPYEPVETDSFWRHLNPDRMAVPRYQAVFKILVWFVFLFVYSQTVQGPLEHFDADRKWDFYEVLLYFLSGSFLIEGKSFLPGGRKFADGKIVRVAPRPMAAVGFWTVVNIIIDVLLVTAFGLRVAGLSVDPSDTDTSQHLHFRSFQVLSCVAPFIWMKLLTVFDGFQTVGTLQVVVSRMLRESTIFFILLTIMGVGFVQSLYALDAADGESGGKAIVINNLIQALLGSPDFESPSERFGYPFGLIVFYGWNFVATIILVNVLIALFGSAYSDVTDNETDEYLVFFAHKTIDLIRAPDSYVYPAPFNLIEAFFIAPLEFVLSNEKYIALNRVVMTAIFVVPLTVIALFESQIAHSKSRRLRQYFQGPPPDEDDDPKIEDPSCDEDEGGEISTVKFEELISVFPNTAVTESSVIHREIRSVKEQLERLEKLLEAKGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K057</accession>
    <name>A0A1E3K057_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_01667</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034535.1">
        <property type="nucleotide sequence ID" value="XM_019173830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K057"/>
    <dbReference type="GeneID" id="30190880"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO06435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="294" mass="33454" checksum="C1FD2E95FCCBF23B" modified="2017-01-18" version="1">MPSSQVLPQQPEIRDSKDYGIKDVWADNLETEFAALRQAVERYPYISMDTEFPGIVARPIGNFKTGSDYHFQTMRCNVDMLKIIQLGITLCDENGDSPEVSTYQFNFAFSLSEDMFAPDSIDLLKTSGIDFKRNEEEGIDIEYFGELLITSGLVLFENIKWVSFHSGYDFGYLLKVLTCEPLPADETDFFRLLFIWFPCIYDIKHIVRSIKTLRGGLQEIAESLGVKRIGPQHQAGSDSLLTAAVFFRIQTIYFDGHLSDDYYKNYLYGFSSGRLGKNSPATHGDNLVLVDKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K229</accession>
    <name>A0A1E3K229_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034667.1">
        <property type="nucleotide sequence ID" value="XM_019172941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K229"/>
    <dbReference type="GeneID" id="30189982"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="681" mass="75678" checksum="A1BFA98493DC1C1E" modified="2017-01-18" version="1">MKNQQLVKQHYDLGHKYMSKGDYEEAWKNFDKAINFGGKSLVILDCKAAAMSKLPEWRQNALQVTKEMISKWPKDFKGYYRQASVLHTMKAYDPALVAVKKAVELGPTQTQNDRQFRAVQELRASITIEKSEHDRSRAANDKAEAAKQAAERRATRKARINYTHLLSRDIVLTIAESGMVENPNFILRMAGVCRQWRDILVGQQGLWGTLVLGKKRMDKKTEVYIERSGGRIREIRISAILDSQLAGKISGLLRPHLSHLHRLIIISTGHTIAHLNHRWTGCMENLQHLQLENTDGIGHEESIVHGLVPPRATSLTRIEITGYRYASAICPGYHFESLQTGLLKPSGKQNVLTNVKILILRDCAFNSAGSGGVMHLEMLLGHFPKVETVELSGLQDLAMPAPDWEPYTPELPFLRSYTINNTSANIWANISTPALRDLSLPSHRLPPLLRFLQTPGLASALSSIRALDISESPATNQDLLKALACLPALEFLNVTGCPLSNTFIEGLVRKTGDKEKETVLPKLTALSIARNDQITGGPVLRLVRSRYPGEDTGKDGGSQQAKSMGSAFKPAKSVFGRPTTRAPASTPTPSAPPKMAQVPKDLPRITWLNIDHCNLIEPSVISHLRERVRFVSNAFGQQINQDRIKGKGKWRWDMSGEMGACKSEKEPCGVRKVPGMCARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2J7</accession>
    <name>A0A1E3K2J7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034708.1">
        <property type="nucleotide sequence ID" value="XM_019172982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2J7"/>
    <dbReference type="GeneID" id="30190023"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="248"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1116" mass="120110" checksum="9B25547265476ADD" modified="2017-01-18" version="1">MTPPSTSRLPQSSSASSPRHASRHGRSKSGTTPNKPKLLPFPDLPELRSSRDSSRATSPLPTPSREITFDQMIMARGGSSDGGQGRQRSSGSGGRNTPTATTATSPSVSSPLAAASLSRARALTAPTSANGSPDARSAPSPRRMSDFQTDAGPSRPSTSAPSAPSVAIAPPIAPPILLAPSSSVPAPATQPRTPVKFSHTDERAHHVHTQSAPPAATSFNPTTAVIPTPSLQPISEHLYNAFLSGMCADVRLIVRKWGVAYDVHKMIMSQSSFFTSLFLGGFSEATVTPKPAFKGKGKARIDVPADNWLGESVELQFDDPNITRAAFEICLARLYCPYPTLNFPTSILPTSTHPLTPSFPSSHEPAYASLNSSQPQNTHLATPRLLLSLLATTVYLGHGALLREVLCMILRTVSPVTVGLYLAFATGDGIGEEEWEGQSEEGAKGFEKVAKPLFAPQRAHPSGMSPTVEEDPMETPSKSTSRPRLSSDSDTKVGHTDPSIYLNGTSDYSSSFQGDETLHSHDQASFASTDVHALPQYYGVVGDKIGEACNVWLARWGADTLHAEMQTPNAAYRIWGHGGLLARFVRALLSSDFFFVKDEMERYQMTRNVLDLRRKGWEEVMEGVGDVSFSGTDVEHEWDEWEDEEREIQRVFAEGIRYCHMTFEDLSTIASDLDPHTSLPYAPLAVLQAAHWAAADLRARVTAHERIEEGQEAEEKDELGLTHTTSEIVDTLRNRRRRPTPRSRVPSAATTTWGASSSTASAFVAPPSSVSSTTDMNHSNHLAQSVWYPVPSDETHRIGASGLLSSGINGVSGVPDFGPDLADVLFQTSPVKSKPAPHGEKSSFGLVGGKATASEIEDKWVDEGGGFALLNLGLGKEKQDQWTKTEPFRFSVEFWDVDKLGEKERYYSATHFYAGSLFNWQMIKRKEKGVQLGIYLHRQSPNEPFPAPSAPHPADGLSLTRTTTTLSTTGGPMTPAAPQALLMPSPVIPGSPPATNNLLSLRMGQQGKGSGMASNVPYHDTRKTTKAYFSISCASALGTALIRFTSGPDSFAHSQSWGWKSSALKSEEYLSVPPVVDGKDDLGEGVLGWTGEVDTSGIESGRGRCTLRATVVVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2M6</accession>
    <name>A0A1E3K2M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034746.1">
        <property type="nucleotide sequence ID" value="XM_019173020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2M6"/>
    <dbReference type="GeneID" id="30190061"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="33138" checksum="BAE3AB895D4585E3" modified="2017-01-18" version="1">MQAFRNFQAQIPALPAVDVTAVSKSFRHTLQSTRERIGHVGPDGITELPAEYKQLEARVDALKEVHQKLLKITKVHERESYDYPADVTEGLSEVGQQAASAWSTFANKNLKGTNLPIPIPNPTAPPPHQPKTLPHALSRAAKSGATELGDDRLGVNLGIYGAAMEKVGDARLAQDQLISERFVTPWQATLSTSISLALKARANVKESRLELDSARAALKGAAPAKQEQARLHVEEAEDRLVQNTETAIGLMKAVLENPEPLQNISNLVKAQLIYYSTAAETLSGIQGQIEEAATAAEGDYRQSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N4</accession>
    <name>A0A1E3K2N4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-type H+-transporting ATPase subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034911.1">
        <property type="nucleotide sequence ID" value="XM_019173185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2N4"/>
    <dbReference type="GeneID" id="30190226"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="42" mass="4277" checksum="041CA42EAC8BA412" modified="2017-01-18" version="1">MASGVLTIAGVWALQDIAVSSPDALKDPKNPFAASKAKQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Q2</accession>
    <name>A0A1E3K2Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034740.1">
        <property type="nucleotide sequence ID" value="XM_019173014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Q2"/>
    <dbReference type="GeneID" id="30190055"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="497" mass="54076" checksum="2DE973DB4427899E" modified="2017-01-18" version="1">MTAAPSYTLDGSLGDTAVRVATLPDPQEDRANNDAFNIDQYRQQVPKWKRIRDHSLTQMLMMSALAFCGPAMGDAIGGLGGGGLATPTTSNIATAISYSMLASVCFFGGPIVNTLGTKWALVIGAATFPIHGSAYYCNSKFGNQWYLILSAFIGEAGTIMSIAPGASRGKYLALWIVARNLGQLIGGAINLSKNHASDKSGGVSPSTYLVFVAIESLALPFALLISPLERVVRSDGTRIRIEEKKPAKEELFTIKRTIFSKLILLSAPWAFWSFFYRQVYGSWSTYLSLYFSVRARALSSLISPFFCIVGCFGLGYVLDLKNYSQRRRAQFGLALVVLTNAGVYIWSIIEQVEFIRDDPGAIDWSDKQYASAFLPYFFVQTTGPLSQSYMYWVLSSFADNAQANVRNGAAFRCMEAIGQAVAYGMNTKTGSNPLVGFCVTAGLMIAALPTFLVLANSTPDRIPADILLEEETRNVKNEDDGTEEKKDPALATIVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K354</accession>
    <name>A0A1E3K354_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034936.1">
        <property type="nucleotide sequence ID" value="XM_019173210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K354"/>
    <dbReference type="GeneID" id="30190251"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="21883" checksum="F516E6A9289A576B" modified="2017-01-18" version="1">MAATRNIKCVVVGDGAVGKTCLLISYTTNAFPGEYVPTVFDNYSSQVMVDGLTVSLGLWDTAGQEDYDRLRPLSYPQTDVFLLCFSVVSPASFENVRTKWYPEIRHHSPGTPIILVGTKLDLRDDPMQVDKLRERKQSPITFSQGSAMANDIKAAKYLECSALTQKNLKSVFDEAIRTVLNPNRRAGKAKKGNGCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K398</accession>
    <name>A0A1E3K398_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034988.1">
        <property type="nucleotide sequence ID" value="XM_019173262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K398"/>
    <dbReference type="GeneID" id="30190303"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="479"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="608" mass="65825" checksum="1CC98183AF8FE00A" modified="2017-01-18" version="1">MTSLPAPSPSRNPFAKPALATEGASFAKSAILPTSTKKATLVPGDCQTPIEKRVPNDFGSAQGTRTSWRLLWRGGLEIGKEGWRLDGITFFAQLSFPQPTPSKNPFAFPTPPPSFSPAPSSPFHSLPGGTTDLCLSLESMRGRKYLQVRDVVDLPDGEVLEEDEDVAGSGVQVSISEQAPLLAGYVIGLLGRDGSLSANGRTKKAIVIGLGDEEVENTLKSTILVYGQLQSSLSKESSESTLRLFVGRRKPPPPPPSEKKIRPGEPLPRAPLFIPADPKKPFRPFARSFSRTSSTSQTQPSIYAPPPSASVPSIGMGVGVGKGKSGQIAPVSGRTPGRRGEKRARLGEAGREEDRKRRAGKIVSQPRLDDRVERRDREGSVRVKEERGSSLAPSEHSFRAPSLSRQSVPPVSAFEQGPGDEEGDEDDIFGKRASSMAPSMSRVSSAGGRSEVGPSVHEVGTAEASGRKRVRVPQQVLDNKASIRKQTLLLLELRGIPRTHDLFKDIFGVTTKGVYFVFRDQLQEYPVSKTDIQRIIHGHLDMYLQSSLPSIPPLPQGEGQEEALKSILEVKQEELSKSGSGVTLHLHEHGDGRVKLEAVVEEEEIEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3A9</accession>
    <name>A0A1E3K3A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035081.1">
        <property type="nucleotide sequence ID" value="XM_019173355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3A9"/>
    <dbReference type="GeneID" id="30190398"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000942">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="198"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="508"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="612"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="742" mass="81359" checksum="7F93EC7EE0F1512E" modified="2017-01-18" version="1">MSRLIILNLPNSASPASLRQVLAAPASLSGCTITDLKFVPKRHFAFVGYSSDDDARKVKEWFDGTYAFGGGGKVKVDFVKDENLVIGEKKDRQDRKGKDNKEVKQPEQAEEEAAPRENKRLAEFMNVMKGVDPTINPEASSSKPEKKEKSKKGKEKSEEPEEPEADDDAEWLRRRQNAALETAAPQLSADEQLILSTGRLFIRNLAFIATSSSLSSHFAAFGKIDECHLPVSTTTGEPLGTAFIQFHSPEEALEAYKKLDKTTFQGRLLHVLPGRARYGQEQGASAVEGKVLGKKDEARGEVKQKVDARRKEEGSRGVNWASLYMNSDAVAASVADRMGISKSELLNGDSGNAAVKLALAETSVIEETKSYFENAGIVLEALQPRVPRSQTTILVKNIPYGTTAQSLTDLFAPHGVLKRVLLPPSGTLGVVEFENHMDAGRAFKALAYRRLGNAVLYLEKGPVGMFKDSASTTTPMSTQQRIESEGKMLAEKVTALREVPDPSDEAGSTLFLKNLNFSTTTPHLQAVLSSLPGFSHARVQTKPDPKRPGERLSMGYGFVGFKTRDEANKAMSGLEGFEIDGKLLEVKFAQRGVEEEKEKGKGGEMEGKTKSTKLLVKNLPFEATKKDLRELFSAYGALKSLRLPRKAIPTSTGSQSTRGFAFLEFTTHTEAARAMEALKHTHLLGRHLVLEWAKEGDEVDVRGLREKVKGEVRGMEDGGREGKRRKLDFSGKGAEENDGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3K1</accession>
    <name>A0A1E3K3K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035096.1">
        <property type="nucleotide sequence ID" value="XM_019173370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3K1"/>
    <dbReference type="GeneID" id="30190413"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24622" checksum="C1065B63931A5E23" modified="2017-01-18" version="1">MANPRQRNKAKSSRSHKPSLAAKRRMHQKLRKAPPLKGPEVLQDKWDKKKTVFQNYAALGLLPSIPIPQQASSRSHRVQLPEVPESAQDEEEAGPVKVGFGKIIRDEEGNVIDIIIEGEEEEEAQKKAEEEMEVDEKSKKVEAKTEVVRQLELLAATSAPVVRHTSTSERTWLQQLVDKYGDDTARMTRDKKLNVWQKTEGEIKRMIKKAGGVGKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K448</accession>
    <name>A0A1E3K448_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034794.1">
        <property type="nucleotide sequence ID" value="XM_019173068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K448"/>
    <dbReference type="GeneID" id="30190109"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="23907" checksum="67A46FE53E8BD169" modified="2017-01-18" version="1">MSQETPSWAKEVPFLYGESREGWTTKWRQSCFCKKTAFVYDRDPLQVKVCHCTGCQKLHGAPFQQAAIFPKDAVRLDTSPDHVRFLSASADFHALSSSPTPIPRKISCGSCGTPFMDEGRNMVLAFPPTFEFARGKGEKGVPEVFRPGCHIFYGQRVMDCPDGLDKWRAHKNESEKMGDTQGEEEDPKEEEVGAQGKEEQTEDREAKRPRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4E1</accession>
    <name>A0A1E3K4E1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034854.1">
        <property type="nucleotide sequence ID" value="XM_019173128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4E1"/>
    <dbReference type="GeneID" id="30190169"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130752" evidence="1">
        <location>
            <begin position="26"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="404" mass="45294" checksum="4D8560A206B8D6BC" modified="2017-01-18" version="1">MSFTTYVAALLVLVAPAAFAAPAAAAEPTLEGQNFGAPGGAGSETALIGDTTEDHEREFIERVFPDEELIVKRDGSIVREPQTVLDDDLKPDASFTPDDWYLFQFIKDHNPSHVRHSPGHLRTRFGLSLYFNWNVMTHLSRWIAAKEHWVSDVGSSHWSLGPDETLGSADWLCKRAFGVLRGECEVKQGVMWKRLSRHSFLKTKMSWSSPSGAGNGETHPALPCIPPSNHSFANPFGTLSHLAFEHLQVGTIVKELEMDTTLCQVLTPSGYAPVTLGLWRGFWVNPEDVSYDKNGKARGWLMYVSIQEDMRRGGEWKAVGCWSDVASETREGVVEWLKTVHEMGYTNGDFEPRHLYVAKGGSGWKIIDWGKGRDRSVDEDSLWKEQMGDETYDLRHISYATFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4L4</accession>
    <name>A0A1E3K4L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein BMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034659.1">
        <property type="nucleotide sequence ID" value="XM_019172933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4L4"/>
    <dbReference type="GeneID" id="30189974"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="94"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129842" checksum="0472CD07FD141452" modified="2017-01-18" version="1">MEAPHKAHHASSSGTKHAKKDAAKGIDRSGGNSYNPKESAAFTNSSFRAAEKSARRTAEKDQRRLHVPLVNRNPDERKVTNEKGKGMDEGSLPPPPIVVGIVGPPGVGKTTLMRSLVRRFTKHNLSQPQGPVTVVSGKTRRITFVECGNDLNSMIDLGKVVDLVLLMIDGSFGFEMETFEFLNILQSHGFPKVLGVLTHVDLIKKASTLKDTKKRLKHRFWTEIYQGAKLFSLSGVLNGRYPDAEINLLSRFISVMKFRPLVFRNQHPYLLADRIQDLTPREAVRENPKMDRNITLYGYVRGPNLPPRNAKIHIPGAGDLEIKEVERLADPCPLPTLESERRRKMGEKAKLIHAPMSDVGGVMYDKDAVYINVPGNFTKGGETLQGEGEKMVMEMQDAQNTFADNIQNSEIRLFGHSSAPLQAPVQRVRRRAEPRAGGPMLGKADDDEFDDDSDEDDFDGEGEPRFGDDESEGDERDVAYADSDSDHDDLAFATGFQQDGKRINFEDDAFPSDEEDDEEGDEDEDVPGWKKNLSGRAADALASRLGRRRNLMSLIYDSPLSPEEISAGKTKASSADAGSSHTGDAYTDQGFYKVSREENKGDEGDQVKQELDRDQLRQKWEGDEMLDSLKELFISGPVGNGGEVDENGEAYEDEAGDFEDLGEEEVGDDGVPYVGVKPNQPSYEDQRAAAAAKKKEALRNKFDEQYDDSDDEGDKMDYYDQQKAEMARQRQLNQDEFEGLDLNARAQIEGYRSGSYVRLEINDVPCELVENFDPRFPIIVGGLLAAEERFGFITVRIKRHRWFTKTLKANDPLVFSLGWRRFQAMPLYHLDDHSIRNRYLKYTPEHMHCAATFYGPVSAPNTGFCAFNSLQGDAPGFRVSATGVVLDVDRSTRIVKKLKLTGTPYKIFKNTAFIKDMFNSGLEVAKFEGANIKTVSGIRGQVKKALNKPEGAYRATFEDKILMKDIVFLRAWYSIEPKKLYNPVCSLLLADKDSWQGMRLTGQIRREEGMKTPLDPNSAYRTIERTTRRFNPLKVPRKLAASLPYASKTPQLSKQSKPTYMQSRAVVLSDDEKKAVTMLQQIQTLKKDKAARRKEKQDERKGEYRKKVGEKDEKRESRIKEERRERFRQEGLKRKRDEMSEGKGRGGKKTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5I0</accession>
    <name>A0A1E3K5I0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035285.1">
        <property type="nucleotide sequence ID" value="XM_019172343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5I0"/>
    <dbReference type="GeneID" id="30189373"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="651" mass="71157" checksum="DA1D04ECDF327D5E" modified="2017-01-18" version="1">MPPPGPSPGSTTPASLSHFAIFNPYLKPSEIHKNPNEEERDRDDEDDQREAAQILFYTAREGGGVSRNTMLRQVGLAKGLMAFGDMVAKEDAKFWSIRSHKQRLIIYTPEPDFYIYICILLANVGENNDPAPAAQGLSDQLLVSGLTRGYEDFRLLHGTLSSQTPLTPSTSSTVDRFFTRFAFEYEASHVSESPSMRKWLGGFPLVHVSLDETVNTFMKEWGEEYPMMIIGKDGPLHTSSEITDLPLLRHLTHLVQLSLPPPPPLPVSSKASKAEQTSSLGFGLLSLGAGKKKAPNDLEKGRKASWPTLGWVPDLRRVSSPSLPSFQALYNTSLPQPPAVLPPVSEAGKGADVGQDKKNWDFGLGAIGDAVGNVRNVFGLPALPGKGTKPASGTKSEATQEISEAASEGTESDVSATIVPSLPSETSETPEPAPEVPDTIVPQVVKELDEAEREEDPQGQVEAGDVSLPELAEAVQADEEMEWDDRSVWITEAGGGLEERRLYWIIRDTILIAIILPTKLEKPYPLPPSVLTLKLVASISSLMWPPPEKGIKSEKGKEKEGAWVYQRGDQMQEEGEIPKDLEKTFVNFRGAFARSPVINEFMGKTASSRFVVAKRNQESEMYLACAPADGSLTDAEQSLRAIVRAHPEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5S1</accession>
    <name>A0A1E3K5S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035268.1">
        <property type="nucleotide sequence ID" value="XM_019172326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5S1"/>
    <dbReference type="GeneID" id="30189356"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40738" checksum="D1AB5322966B37F6" modified="2017-01-18" version="1">MFVSRSAIAGPSRIPIQATQTVCRRAATRRYASEAQEESAEPADELSQMKLDPSPQLPAGLQKREGRIFYQDWMRVEGGQFRVPQKGQKAKWLGGHVPYTSNPSFRPPPPLSNYTQDAIYADLVRGADVAEVSTKFNVSKSRVDAVRKLKEIEIEFQRRSLPLQRAFLEGMEPLLGVRTPINPRTKKYDVAIARDIDMAYESHPSVSAERLEEQRFESGVGQEGAFGDRSRESAQPGIERTAWEWRDEEKALEDRRLLAAKEAEVKQQPGHEGIVHEVLQKEVQSSSMFPTPAVEESIKRKEREELKAAKAKKDHVDVEGVTVGDIHFVDTSFTKAFVSENKGQKAREKRERRKNRAAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K675</accession>
    <name>A0A1E3K675_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035539.1">
        <property type="nucleotide sequence ID" value="XM_019172597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K675"/>
    <dbReference type="GeneID" id="30189630"/>
    <dbReference type="OrthoDB" id="696816at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="366" mass="39334" checksum="9062C5199FA8F712" modified="2017-01-18" version="1">MSAVQIPPGSSQLALNELGYPIFPPRQNYSHVEALLERAKMVDCGITADYYYLSEDEDDTMSDDGLPAASPVVNGDPAPTYGPEEVLHQAYLASRSTYSMIESPRVHPEEMVLPSWSPPSPVYCPASPVYCPASPVYCPASPIYCPASPIYSPASPTFSGFSPVYSPASPVYSPASPVYAPTSPVYNTTSTKIVDETLPASFPLSPLATISPTDALWSSVLPQWLPGSLFTESPDSICEVLCVGEDWDVEELVLPPAVCEGIDPLRAPCLIDRESFEHGVNSWVCPGSPIPASNITDYNTEGRERGASLEAEETWAASLTVYNASPESSPCPLLGKRKVEEILEEAAAEGLELPSRKKVALLRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T2</accession>
    <name>A0A1E3K6T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035560.1">
        <property type="nucleotide sequence ID" value="XM_019172618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T2"/>
    <dbReference type="GeneID" id="30189651"/>
    <dbReference type="OrthoDB" id="10321930at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44007" checksum="F90A3116A36673BA" modified="2017-01-18" version="1">MPLQYKQPAISYQPRRPRALSSASDISVPSSLSAPDAATVHPDWHDTALDTLLVASDGVFFYVSRTLLHGSSEVLRDIFDSIPTPSPESPYRPLSKVKTKPKPPPQQRIDLTDPYESSVPLAFFLAILTGTSLSKIRRKFPRKQVQTFHLALTLVDKWKSPLVKGVMQGWLCELAMGGYDDEQFRPYEVFVLAAKAGMPTPARMVLEELSESPPHTLPTPFKPITDQYWHYTFTPENTWDYNQWSRGVWEEIGVKYLFAMKEALKCEGRKKRGEVFMKALEDDFYDPMAPETPKATPLRLRFTPSTVTTPVRVAPVSSSIKSPKSSKRKEADKYIMEFIEQSSSVASVPSSVASSVTSSEIAEKSHSSRSEKSVASSSDSSKVQLRGTLVIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K781</accession>
    <name>A0A1E3K781_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450, family 51 (Sterol 14-demethylase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035794.1">
        <property type="nucleotide sequence ID" value="XM_019172852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K781"/>
    <dbReference type="GeneID" id="30189891"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="61732" checksum="D453EFCD42B98BB7" modified="2017-01-18" version="1">MSAIVPQLQRIAHEAGAYVPGWYTALPLALRVLVTVVGSIATIIGLNVLRQLVIPTRKDLPPVVFHYIPWFGSAAYYGEDPYKFMFECRDKYGDVFTFILMGRRITVALGPKGNNLSLGGKISQVSAEDAYTHLTTPVFGKGVVYDCPNEMLMQQKKFIKSGLTTESLQSYPPMITAECEEFFTKEAKITPSSPSATMDLLKAMSELIILTASRTLQGKEVRESLNGHFAKYYEDLDGGFTPLNFLFPNLPLPSYKRRDDAQKAMSNFYIKIMEDRRKGESDHDQDMIANLQNCKYRNGVALTDRDISHIMIALLMAGQHTSSATSTWTLLHLADRPDIVEGLYKEQKEKLTNPDGSFKEYRYEDLKELPLMDAIIRETLRLHAPIHSIYRKVMSDIPVPASLSAPSENSTYVIPKGHYILAAPGVSQMDPRIWADSTTWNPARWLETDGVAATAADEYTKGDQVDYGFGAVSKGTESPYQPFGAGRHRCVGEQFAYTQLSTIFTYVIRNFELKLAVPEFPKTNYRTMIVQPHNPLVTFTLRQPEKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7F5</accession>
    <name>A0A1E3K7F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035324.1">
        <property type="nucleotide sequence ID" value="XM_019172382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7F5"/>
    <dbReference type="GeneID" id="30189412"/>
    <dbReference type="OrthoDB" id="2576500at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="453" mass="50763" checksum="EC51B656CD311988" modified="2017-01-18" version="1">MSKKHLRNDRVNDDQDRRSPSVRSLESEEGMSRVSREPEIVMLSPSPGPKTIAEPAVGPRGSSSTKNREAASRSPKSPHHLPLLFRSSSLALRPLVTDTIVPQHHRRKSSSSHVQVRGGSGSPRYSSSPRSPRAPGHPTRPSYHHPAPYYSSPHAREYDHRPPLYPHPPHHAPHAYDPYSPAPPVYPHRHHSSLPPIHTQQAEYYPTPISTDRLYPPGPPPGHPHPRAYPHAYEAYNLLYPPPSYVYPPRREPGYRAPWSAQRSRLHGHPYAPPPGRGYPEDGMRYHSAGPVPSEGHRNLAAGPSAGVRERRSPASAIVPRGAGGANFKSPRKRADDMQLSILSDVFQRTAYPTTEERDELARQLGMTSRSVQIWFQNRRRAVKVDQQSAAERAEAEYRELAVDPRTHDMLPGAMYDERRPMSVELRIAHDAVEDREGVVREGAGVKRERVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8V3</accession>
    <name>A0A1E3K8V3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035527.1">
        <property type="nucleotide sequence ID" value="XM_019172585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8V3"/>
    <dbReference type="GeneID" id="30189617"/>
    <dbReference type="OrthoDB" id="10355737at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="587" mass="65597" checksum="571A600FDEF26775" modified="2017-01-18" version="1">MSDINWNPQKPPLRRMGKWFYNASSASGQDPTLSATDSAYYSDARSFRSSRYGSKADLAESGSPRHDKEGWYNKTKKRMGSILPFASKRDHSFISEDDLQDGYDSRSDGYRSDSSYSPYSSAPGEEIAMNLEENDGSLPPSPIVPHIPHELHNIAEDADGEQREESSFHSSTRTMDLSLHHPTPIRPQIFPDHVEDAWDEKHAEYGHIDNSQSQAGGHVSSSRPDHDGEVHQDVEREVTREGSVDCRSIPHSSRRSLGTTSATSSRQKIRYLFTNPASTVRSLVATAKGKLFRARANKSPYLMRKQGTRDLSDIYIRSSTGLATDMDEAPEVHPLRSCPIQEERRGLDVMSHWESVGADLDYQAVVRSEGGLHDRAANHHGSQSQALSDLEIGVARSVGRRLDEDSVTDSNAAPLDVFSSDGTPASSDTSLQDSRDDLSISSNHGDLRERRRDGVVFLDRSTMPSTLNDVLSGYPWSTSFSYSTDHSPISLHKISQKDKRLSSVSHISKMRDNTPRLEVDYGPSWLMPDDSGRTVHEVLLEEQAKRDARLEDVREKFEEQSKYLRDLMSDEGQIDVGDASYLSQHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBA9</accession>
    <name>A0A1E3HBA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027775.1">
        <property type="nucleotide sequence ID" value="XM_019180245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBA9"/>
    <dbReference type="GeneID" id="30197490"/>
    <dbReference type="OrthoDB" id="10337280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="120" mass="12266" checksum="67AF7AABA6CC4AE2" modified="2017-01-18" version="1">MPASKFSKQAGSIDASNQPPTSPGSPSPSGKWNQGGLSGSHSAWESQDAKQQERKAQNQARISPSGSAVDRRSNTPLSVILADNTEGPFQVVSGNDGDRTAGDSASSAPPFSTNSRAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH17</accession>
    <name>A0A1E3HH17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation machinery-associated protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027894.1">
        <property type="nucleotide sequence ID" value="XM_019180125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH17"/>
    <dbReference type="GeneID" id="30197365"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="211" mass="24021" checksum="7D7D507E3E1D4FB1" modified="2017-01-18" version="1">MGNRRLTKKAIKGKEGLHPGSRKAHQLTRVNLRLDKLQSQGKIRKDLNTSKMTRPLFFLHSLSSPNPLTLESFRALVSEVYLKRNDPRIDELLAERRAGRPKQKELLELEEFRRRERAEYDSGMELPDMTHGPTTHLMHQWIMADASINSSHLDLMRHVRLSPKGEPVMTKKGSTEEMGLDKLEGEVGAGDDWTTLADGEKGEGEAMEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ20</accession>
    <name>A0A1E3HJ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027934.1">
        <property type="nucleotide sequence ID" value="XM_019180080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ20"/>
    <dbReference type="GeneID" id="30197320"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="582" mass="60877" checksum="5C6C04241979D6A6" modified="2017-01-18" version="1">MNTHSPYSPQPSSISQLSHLNPHAHPHSHAHSHSPRTVSITMEDYLTDDGGEEHQLNMDMVHDFGGEGMGVDMREFTRHDDLDETISHHELTGSTPHPPASATSASANDGSNYGHTQTQARATPRTGREERSASGRVGGEGRPGSGSGSGASQGSAGLDSMFQTETGLDEDDDDDEDSSSTKRRKGDKGSAFETEKDTQRRKIKIEYISDKSRRHITFSKRKAGIMKKAYELSILTGTQVLLLVACLNAPEGFGPDGEPADAGPVPATKAKNGGLAIRPHKLTPQATAAMAASAHAASGIPNDMPSSSHSHPHLPTQNQGQSQAQAQAHAQAHAHAQQQLDAVSALGVGQGSPSSRPKKRMPSNRRTASSVGGGGESKPELSLPLPSEMPPVPPIPDIHRAPPPSASQQSTPQPRMIPNPSAVSAVQHQQSPLTTSQFHLPVEYHHPHPGQPTGGAGAGHYYQPAPEGTYYYASSPAAAPTPSSASVSVSVSVSGQGQGQGQGDGAGQDGGPGGGGGGGQGGQGGGGGGGGQGPPGYLLQQHAHMFHNPSPQQHQHQQQHQQQQQHQQQQQRERERLMGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ82</accession>
    <name>A0A1E3HJ82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027969.1">
        <property type="nucleotide sequence ID" value="XM_019180068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ82"/>
    <dbReference type="GeneID" id="30197307"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="132" mass="14953" checksum="C7AF20E634C7793C" modified="2017-01-18" version="1">MSVHDENSSVVEEEVEEEVVEDAKDGDNSSTVDEEDVDDAEDSEEYIDGESSDYLYSDSYLFIPAEEQGSTMGRQTVARHKTVSRIDRWLANVTQASHDTLPAHPDPGIEGQLSYLRMRPSRLRQWRSDMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJM4</accession>
    <name>A0A1E3HJM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027891.1">
        <property type="nucleotide sequence ID" value="XM_019180122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJM4"/>
    <dbReference type="GeneID" id="30197362"/>
    <dbReference type="OrthoDB" id="10392124at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="85" mass="9423" checksum="FDD2E74E7968CA2C" modified="2017-01-18" version="1">MSSLDSTTSSCPSDVKLELSSCDRYLEDIIAGIPESERCSCGKKYKKEAILSDHDRRLSERSAASASTSEEQEVEGEVMIHKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP22</accession>
    <name>A0A1E3HP22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028053.1">
        <property type="nucleotide sequence ID" value="XM_019179992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP22"/>
    <dbReference type="GeneID" id="30197230"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="349" mass="37944" checksum="AEAFE6DD479E32AC" modified="2017-01-18" version="1">MSSAHTITKGDLVLVTGPSGFIASHAAKEFLQEGFRVRGTVRSEEKGQYLTKLFEGMGEFTYMIVKDVNQDGAFDEAVKGVDAVAHLASPFYVSDVKDPQELIGPAVKGTTGVLESIQKYNPDVKRVVITSSVASIMCTDSVKSPYIYTEKDWNVDSAAHVEKNGLQSAGFHSYLASKTLAEQALWKFIEEKKPSWDAVAINPPYVLGEIIHQCDKPESLNTSVAAFYEWASGKKTEDDLPAPLGNWVDVKDVALAHVRALTVPEAGGSRFIVGAGALAGQDFVDGIHKNFPAVKNVPVGTPGKHDEICKDLDIFDGSKAEKVLGIKYTTLNDSIIQMFESLRKRFGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVG4</accession>
    <name>A0A1E3HVG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028224.1">
        <property type="nucleotide sequence ID" value="XM_019179802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVG4"/>
    <dbReference type="GeneID" id="30197031"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="766"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1050"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1151" mass="124797" checksum="2D997CABC64982EF" modified="2017-01-18" version="1">MQRTETYSPNWFVRAVTVPGPDTDLCLHVSFDNAKFIFGAGEGTQRAYAQKKIGFSRLAGVFVNSGESKGRGGLPGIIMSVADAGIKTINVVGPPDLTQYIGTLRDSLTLNASPYPRDAQPGTPVNLFTSPNMTVRSIALFPPTPPHQRSPPTYDPYTPLGPVFRPSRLSPVDLQKWCHQVVSDMFQNNTTARLSQRAPSPPFSPGAKTRSEWASANVLLSPDGTINAARPDTRAPLPTPSETDVNTQMVYILETPDVRGKFDNKKAVELGVPNGPLRGKLTRGEVIEFPDPEMEGVLKTVRPEECLMGGGPGAVMIMVSCTLKTLPDLLRNKTFTEYQPLRETPGESARKVHLMVHRIPREVLADEGYKEWMRAFGPETQHLIADTTPTTSQTVFNSAAWATLSLSHLDSSIFHPPLLHPTPTPSSSLSLSPSLAGFLDLPPKTKILEPNHLCRMHPLSDMTEFRWHEKDVPFTIGPEEVQEKARERVEAEYPEYAEACRKAQDAVRADPRSNEVQGGEPGDDLVITTLGTGSAIPSKYRNVSSTLLTIPPPPTAPDSPAQSILLDAGEGTLGQLRRRFGKEGELEGVLRELKAVFVSHMHADHHLGVNAILEERFRMGITTPLYVIAPQLIALNLRETATWQSAASDEGLRNVKFISIERLGERVALGDELEYVGRPTSFAVEPSPSSHSLAGATSPSVSPTRLARRDKERSASLERKPKEYGNKITWPFESIFGHSAALATTQHANIQSFLSSLSLTSLHAPRVWHRGRAFGLVLQHSSGWKLVYSGDTKPCAPLVEAGKGATILIHEATLEDDKPEVAAVKGHSTFGQAVDVGKQMGAKYILLNHFSQRYPKLPKMPGVVPLAVAEEASESARLKREESVPEGILKEASIEEDVPENSSTETLAPLPENVGLEASSEASDPPVLPSVTPTAPTTDDTSSHLPPPSTAPPHVSISFDFMSLRLADMWKMPYYMDALSILFAEPEEAEVEDGAGSVVEGKANGAGTGEQGGATGTGKGKKAEKREKKQAQKAAEGEAKIQGPGQGQRGEVKSKRALKKELANAQKEKQARKSGEGRREKGTLTESELAVESLVVEDVVVEEAVVNEVDAKAMGAMEIEEKEAVEAVGEKRAGSPSIEEPEAKRRSVDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5L5</accession>
    <name>A0A1E3I5L5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation protein SPT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028370.1">
        <property type="nucleotide sequence ID" value="XM_019179682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5L5"/>
    <dbReference type="GeneID" id="30196905"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="433" mass="48473" checksum="69DC28C0E886479D" modified="2017-01-18" version="1">MSSLALPAMHHTAHTPSPHPPPPPAFPNSSRVRKRSTPPLEEDSDDEDEDDKRRGPGPNKKKASGAGAWGWDDMGDYKYMVEIRQMMFVFGEVQTPLSETVKLVEDIVRSQIIEIVTRARLLTHLRSSRFLSPEDLIFLIRDDRAKVNRLRTYLSWKDVRKRAKEEAERAGQGEDVDLEEGGGGEDDKGLKGRRQMVKLPWELLTPFTAFLRSIPGKEEDEEEDDDELQAYEDSMQRLKEADEITKKMTKGEYAQYSECRQASFTYRRARRFREFINFGAYLDVRPNDDIVDILGFLAFEMVRSLCVTALDLRERLEKTKVTGAAGAGGVAMEKKTSSNGGDPQSSPTKPPAPLSSPIKEPSDLPASDEPPKPAHPPNPPSLFAPPPSARQPLQPCHILEAFGQIQRAQALKRVGGMGKFRGGVVGRRRMALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICK4</accession>
    <name>A0A1E3ICK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028696.1">
        <property type="nucleotide sequence ID" value="XM_019179340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICK4"/>
    <dbReference type="GeneID" id="30196549"/>
    <dbReference type="OrthoDB" id="10277443at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38325" checksum="3326C3F7BCA51AAD" modified="2017-01-18" version="1">MASASTSRPISRPSPTILYHPFQLLQPIYHTLIDYLFLISPLSCLRLSRYHYNLYIPLLYDRVVITKAKVDIWTTALKRAKPRDLVDVAVVMRQCTKVLTLPDWEGLHGMVYMSDDRVAFPGVTSVLVPPRLFAACPEGRRAGVMEDLEILLSERCGSVRNLVVQLGAVDVRTALPQLHSPAKLNFPHHCHLNAETLTVCVPVIPVGASDPFVWQDYINNVADIAISWAVKGKIRYLFKMDDKTYKSLEYRRTFCIALIGIISQLGSFFTRAPSCPIQIQLLLCHPLAESTIDFVRKNTVQVLAPSLGENKARLMSFLDDMLEIKKVSAEEAMWAVEGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICL9</accession>
    <name>A0A1E3ICL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028701.1">
        <property type="nucleotide sequence ID" value="XM_019179345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICL9"/>
    <dbReference type="GeneID" id="30196554"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153:SF38">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23153">
        <property type="entry name" value="UBX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="304" mass="33127" checksum="FFE20A605B7D7BA8" modified="2017-01-18" version="1">MSTPKTPREAALAAAEARLNPPPQTSDAAAQAAPASASASPSGTRPLFAPAPRHTEKEERDLTIKFNRLLDRGIIRDNSYQDAAEAVETLIKISTNILNSDDPKFRQIKASNGMLQKKVLAVKGGHDYLIALGFRTQTADFTKTYMFQKSLRSVHELEIGTRILQDHLSTLQSRVSASAQSRLSHAQAEAARRAAALAEIEADRDSVRLRALREKVGREAREREAREKEEALKDAEGAGMGMGEGEGEGEVDAQGTARREGVVSIEQDEDEDEDEDSEEEDHVGYAAASGVNESYWGDGRRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEZ5</accession>
    <name>A0A1E3IEZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028913.1">
        <property type="nucleotide sequence ID" value="XM_019179155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEZ5"/>
    <dbReference type="GeneID" id="30196352"/>
    <dbReference type="OrthoDB" id="10283873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59938" checksum="04CA8EE7A35343E9" modified="2017-01-18" version="1">MTLPTTPTSSDPILAFDTHVTVGILHALPLSDLLSACLINKSWNALIKANSESIYRSLAHNIGIDARDVDILEGYHQYASSHKEGDEEGAWNREVFDVCGIKPPSEDARKEISWERACQTYLRRKRNWVSGRGTVGYIGVPDNDVASVAVDEAQQVLYVGTWNDTVLGVDPAKPNELFSEMEFDDNGAVQELFWQNDHLIISGSEAVHTWVPDSNSRGFLVPSETIEYKNGDGKRTHVGERNGKPVVVTVKEPHILLVQDVVGGKERKLLLNNLPAKKLTWPKSKVIVKDDYIFLISGGLHIYPVSSPATLLASLPKIDMLPFPNAVVPKHVYSLGMNHEGVKPPVAEDGEALVHKLEMVVEKSEDVGMDAMFNFVSDVHVTATDLFVVGTTGTVYVLRSYKDVLSIADPKKRKAALNEQVIALKFKGGLNSIAVHGENVAIFCVAGIYLLHTSSLPSSSNTQTTIPLHLLLDAPSALLPQLEESIYLVLTRSRLYVVWSASIEFDEGEIVDGKGVGRCVDEELCEGDGYCLKVWDFEGEDDGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFJ9</accession>
    <name>A0A1E3IFJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028954.1">
        <property type="nucleotide sequence ID" value="XM_019179036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFJ9"/>
    <dbReference type="GeneID" id="30196229"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="504"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="623" mass="69985" checksum="01042A425A807315" modified="2017-01-18" version="1">MASLQGADVPEHFALPALPEIKGVDPTRSVVEAFRIAAAKVVADAWEEDIEKIFPAVELGKKGADLSVAVVRFKRGKPADILPWVNKITESFQPSVFFSKVSSPDGKFLWFTFNRDAFGYHILRQINLTSAAALAKPEEPTLAYGTTTEGAGKHLVVDFSSPNIAKPFHAGHLRSTIIGTVISNLYEANGWKVTRLNYLGDWGTQYGLLSIGFDKYGNEEELQKDAIKHLFEVYVKINNAKAEQKEKIDAGETIPDEENIHLLSKKVFKDMEDGEPKAIAQWARFRDLSIEKLKGTYEKLNVKFDVYWGESQVSNESMERAVKIVQDKGLTCEDRGALLVDLVKFKMDKAIVRKGADGTSIYLTRDLGGAYDKYQKYAFDKHIYVVQAAQTLHFNQLFKTLELMGEPYADKLEHVTFGLVKGMSTRKGTVVFLEDIIQEATTTMHDQMKSNEAKYAQVENPEETSAIIGTSAVKIQDMAGRRINDYDFNMSRCTSFEGDFGPFIQYSHVRLCSVQRKNPNVPLPTSINDINVSLLNDPKILDILMQLALYPTALRNAYVQSEPSQLVTWCFRLSHLVGAAWETVRVTGEEEEVAKARLFFYITTREVLASAMRLLSLTPIERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFT1</accession>
    <name>A0A1E3IFT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028948.1">
        <property type="nucleotide sequence ID" value="XM_019179030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFT1"/>
    <dbReference type="GeneID" id="30196223"/>
    <dbReference type="OrthoDB" id="2576405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="517" mass="57576" checksum="3AE9C7C19463120A" modified="2017-01-18" version="1">MHTPTSDPPGVSLAPDTADSGAEAFHMPPASELGHPANRDKPYPLTLVPFDIANPPQHEEFLMIRPYDDIVSRYKLRDYWVEVYEAGRIGEGVEYEDTFVLPYLRSFYQELEALKFLKARRGKLLQIFPTTFTTSFRLDLDIYIRPGDMVKDTLDGNDVEAKEARKRKGKEEQSVSIVTSTTAKSRMPDVGLVGQSSGAKISTGRSEREFILYSINHIKWSPMVQNVSDQAEKRHLDDINLRCALLDALFQTLYHLHNAYRVAGCRLAIAWANEFFTRMVNVTGKCGPQRILVEASPKSMAMSSKRLPNCAADGLNLDDLITLVHDDDWEAPNSLIRDHDDWHYDEEAKYRLDATILMTLATTTHATTLGDVAVSGGSKRGREVDHDEYQESSLPSKRSRYARQGVDDDSFVGPVDDSAYLPTQSQSENILRPPSRPASSPAVASSALSPNRTVATNSVIDEASLELEFPSEDWTHGDYAGALEKTGTKVLLVGPQEMDVLLARAARQGWAEALKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGF2</accession>
    <name>A0A1E3IGF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029022.1">
        <property type="nucleotide sequence ID" value="XM_019178928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGF2"/>
    <dbReference type="GeneID" id="30196114"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="319" mass="33868" checksum="3FBFE9EA12328536" modified="2017-01-18" version="1">MSNDWWSTPSRTAPTPNLTRSQSLRQSRYAPTAGDELDPEDAKAADAIKFLPSFASSQAGKMTLGTSPTGGMSTYGGYVGSPQGERRSPQGRLSGSVHEANSPRHTTRARTLAHQSGVLGSSYNPNAMDEDMPPTASLRDSVTDTRSAPVLATNELPTPPSLIPTRTTTSLYIFGPPSAILSTLEPYLAQFGTVQSYHPGPEGSNWYIVEFATPLAASYALRRHGDIVQGKWMIGFKVGNGGSMEGFNAGAVAEGGEAVVVPPPAAGTPIRVQNASILRPKPVPQAVVKAAKSGNEYAWDEPEGQPGWTGWVTERLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGK1</accession>
    <name>A0A1E3IGK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029070.1">
        <property type="nucleotide sequence ID" value="XM_019178976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGK1"/>
    <dbReference type="GeneID" id="30196168"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74387" checksum="8CA741BFA091C240" modified="2017-01-18" version="1">MDEYASFPSAPISSQPNTPGWYTPSANVPGRGGYHANPSEPPDYFPQFQPNPPQVSINDKVKVPPPILLRYAGTNTLSNKGCLKIHVPGWATTLIQPPQIFATGERLAPQDDTVLTGSLEVIMKERRKVQAISVGVQSVCRLFMGDTRGWEEDGVFERGVEVLGGNEEGIWLEQGSQSFSFNILLPATLATTNWHKFGRLSYIITARVQGVSPAPYSNFPSLFKANTSLHLDPEIRFVHDFEKVIARSAQVLEEERRGRAREVGLSPVREKGRSTSKGGVVGHMRDLSLGSGDKDDRITHGRTPSPSMGGHYTRRQNAENPQTTPPAESDLSKHLQLRSEKTGWMKGDLVQSRELWIQAISPVTGDVVPLDMRRESFMEGLGPWKFRASADVFAIAAVILIDFRLPSPKPTTSIFLLRLTLSQRYTLTSPRTPDLPPYEPQPAQDFVIYQVGKPGWQGERFPGLDVGALWRGTEVEGKIAESEEGKKGVSSKGQSQEGWKIKAVARLPTHDKIRPSTNEGTITPIRVSHELIIQVYYSCYGEKLNGEKVNGPGELRRMTSRSPINVPSCHCIDEALHLPPYDSLSPTSSSSGIDSVISSPPDKKKWCMCGPSFEELGKAAMEKDRIREALEENMEEEEGGGAGGSRDAERVGRLRVRAEANARNKATSGGSGGSGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGT1</accession>
    <name>A0A1E3IGT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029081.1">
        <property type="nucleotide sequence ID" value="XM_019178987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGT1"/>
    <dbReference type="GeneID" id="30196179"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129751" description="Carboxylesterase type B domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="62"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="804" mass="86059" checksum="47E59802A3A58237" modified="2017-01-18" version="1">MRWSLSLASLALLSLTTAAPLQCRHKSDPDSPHDYVAAAPTATIYPDTAGGQPVNIVGFADDRFGADVYLGVPYAQPPVNKLRFAAPQSYVYNTESYTAQTQPPMCLQNPQESEIIYGTENSEDCLFLNIFAPAGLNLAEEKVPVMVWVYGGSFTSGSVYPYNGSALIQHSTETGKPVIHVALNYRLGALGWGVGSGFAENNATNLGLRDIKKALGWVQENIWAFGGDRDQVTVFGESAGAISISLLYLDPGTTLFSKAIMESGAPSSIPLGPQESTWEDAYEALLKAANCVDFNCLRDLSGEAILAAQMNVKNQTAFKAGFIYSPTIDGDLIPDSPHQLVLDGKVANKPFITGNTKDEGTRFAPTSINSSPYGLLVLNLFEPDDPHLMTTRKLLRLYPNDGRAGSPFDTGSQTFGLTAAYKRFAAIFGDLFFQSQRRYFLRQANAHGNTQTWTFQFEQPTPGKPEYLGIYHSTEIPYVYGAARPDIGQQGFSYTYTEADHRLSHVIMDYWINFANYGSPNGPNDTASSSSNAVYWPIHDSDNKQILRLKADNISVFRDDYREAGTDFITSRPKAFSLRRSLDIGVGAGVGVGIDGELGEGLDASVNVGVDGYVGAERKRASLTAALDEMPVVDLDFTTFESKRDLNLGVGVGVDGELGLALKRDLDIGVGVGVGAVVDLQLKRGIDISADVAALGQVDLGLALKREFDLEAGVGVGAGINLNLKRDFDLEAGVDVGAGLNLALERESDLEAGVGVGAGLKRDLKLKVDVVAAGKGILDAEIKKRDDLNIGVGVGVGVGVGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGV1</accession>
    <name>A0A1E3IGV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029101.1">
        <property type="nucleotide sequence ID" value="XM_019179007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGV1"/>
    <dbReference type="GeneID" id="30196200"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16035" checksum="7B37655E7C61673B" modified="2017-01-18" version="1">MAQQRKTVGNSSQAACKQYAAQMKKDVLGADEEQKAMRKKEGVMSIQALPAAVVHRSSKSTAKAFQAKLWELPDKMTLYPSDQNLEQVLDEALSQVKSSWSALDGALLMKKTGSRPDLQNTNSTGPNKCTENWQLFFCQVQLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN0</accession>
    <name>A0A1E3IHN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029170.1">
        <property type="nucleotide sequence ID" value="XM_019178893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHN0"/>
    <dbReference type="GeneID" id="30196077"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="738" mass="80316" checksum="99D3B57FF0956D17" modified="2017-01-18" version="1">MYASNFLANKLGDRGHGVQGSQIFRPQTPPSPTHDPFIPSPSISSSNPHLAGSRSPSQSGMRTPPFPGPGIEGIPDMDNAMGSSSVGVGVLFAGPDDDHPQPQESLSRSANDGKGRSRIPNPYESSSEDSDDDRDEAEMDLDQVETVRRSLLRPHPEQQQRQPLSERAKKGWLAHQSVFPPSSSSSDDESDKETESESDFEGSTILGSGRKGRRQSEIDSNMYDTGTMPAAYNVHTNMEEPLLGAEDGDRLDRVPVRLQVYHGRFGHWDREGLRKYKDSGFLAFWLSSLLGILIGLLFVWGSTDPPPDAPSSAPSIIPLLPLLLMLLIPPLVLPPAFLFLLQKTVRPVLIATAGAIPFSLFICGWWAIGASFETQGLDGKEKSEQWWGTTALRIGAVLLWALAAWFGRLMWLRRRRLDRTASVVELSTKLLLNHPPLLILTPLLLGVFAIASIPFLTLLIRLGMIGYWRHPRENTWVFHIRPYAGWLIFLVTLIWVWTWGVIRGVGRVAVAGVIGEWYFHREDHRRQDIIQVTTAAVHRATGTSLGSICLGAGIIAVVRTVGSAAASLKQFTSPRNPKLPSFLTFLHHLSPVLTVIAGVLDQLNGYALVYVGITGDAFWPSARRSVSLAGRRKAGHLLDYTLIKLLLTLSSTAMGLMTATAGYLYMTHTLGNPGYAPVAGLVCGGVPFLAVRAGAGVLTDAADALFVCYQIDRELGGQHSEEAKGAFVGETPSGANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIJ4</accession>
    <name>A0A1E3IIJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029236.1">
        <property type="nucleotide sequence ID" value="XM_019178753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIJ4"/>
    <dbReference type="GeneID" id="30195910"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="134088" checksum="5D33800B80F7412A" modified="2017-01-18" version="1">MQKDRIRLYSTSAAQTVDNLSPYQSEDLDQQGEEPELERFIASASEVQDNSLPPPLHAALASGSLTSASEFVRLFEQYDAGDSPAGEVKKGKGKGVSSTSDMGGVKQLGLIFDLFRKTAEDTQWAWLERKMRKVLDSKYTPSQGIATAIKGYALFELGTPGPQVIDVLQGVLPSNNSLPHAIAGLLYAQLDEWDLAREEMSRNLKIVFALIMGEDMQVEPYPAIDRRLLYLYESVVLKAGRNHDLVDIILHSASPRMRYHLLGQARFDNRISALQVVDIFGRAVSRITNPAQWWIDEYITTPTKDMVWMGSFIVSALSQDKTRLGEALALHDEIISRQIHITPSISFFICQQMAIYRIPSARATFHRMLELHPNPPRTSLRRIMHFAARVGWEEEEANAWDLLSEKGVPTIWEKTILASVYAFQGRVELVKKVLGERFPGWRDNAEGLQVLFTAYINNNEAALAEETLFQIDTLSPRLYVYNTLLQLYADQANLIPALELFDRLLEHPTLRPTKHSYTALITLFANRRDPTNAHNVFESMADAGIQPDALAYAAVINAEVEAGDWSEAARSWTEAPVKVREHRTVLSAVLKALVWLPAPTEHVVGIFRRIRNPSKHAWALVIQSACDSGNMDFARELYNEMDVASRRGTSPSPDVYTFSILLHGYMRGDDSASARAVYDEMTERGILPSSVTYGIVIQSFADTRGARALEQAHDFATSVYREVQKGKIADVRSDKFNTRRNIFTPLAIAHGKLQNWERAQSYFDLIDPTEESLEPETDNFLAASPQQKIITWSQLMDVHRRAGDVEQVVKIWGDLFRFAIDAIPLVARNESEEADMNRAFAGSNINVPGGGKNSRKRIPESILCIPLSIALDSVSSVGDGKAVRKLWSSVSHYHFGFDAANYNHYAIALARTGDVEGAFRITERVLMRRFARIKFRGDAALREKKKDLRRHSRGQFIRPAVSSMDGWDHDVEEIPEEEEEDYEFEEGENEDLRSDPEEMSAVLDLKVDPVLGPPNRRHQYHSSSSPFRPPHLPSSSVHDAKESVLGMVDKMGGEDPVPKTVALLHRWRPRDTLWRPSILLMNVLDSVFGQVEDYGASRGWVSLQEKAPTTPQLEDPEQSQSPSQFRKKNGFQGTVLPLYGNTPIKDYQTGKPLPISPRAFRVRLEDRYAKAVELVRYFRRRKEERRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ20</accession>
    <name>A0A1E3IJ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029044.1">
        <property type="nucleotide sequence ID" value="XM_019178950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ20"/>
    <dbReference type="GeneID" id="30196138"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="271"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="470" mass="51420" checksum="F9D552A611354669" modified="2017-01-18" version="1">MAPITVKKICCIDAFLADLLSLSGGPTCAVIPNIIVTIVDLNQQRIDAWNSDQLPIYEPGLDEVVKAARGKNLFFSTDVDKAIEEADLIFVSVNTPTKKSGVGAGYAADLKFLQLATRRIAEVANSSKIVVEKSTVPCRTAESMRTILEANSKPGCHFDILSNPEFLAEGTAIADLFAPDRVLIGSLQTEQGLDACQALANVYANWVPREQILTVGLWSSELSKLAANAMLAQRISSVNALSAICEATGANIDEVAFAVGKDSRMGAKFLKASVGFGGSCFQKDILNLVYLSESLHLPEVAKYWRAVVEMNEYQKDRFSKKVVETLFNTITGKKIALLGWAFKKDTGDTRESPSISIANHFLSEKARVSIYDPQVTESQIWLDLTEYGDIPAEPIKPHVNIVKSVEEACAGAEAIVICTEWDEFKTLDWKKIYANCPRPAFVFDGRLILNRKELTDIGFKVVTIGTGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJN3</accession>
    <name>A0A1E3IJN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029358.1">
        <property type="nucleotide sequence ID" value="XM_019178657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJN3"/>
    <dbReference type="GeneID" id="30195814"/>
    <dbReference type="OrthoDB" id="2573334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="723" mass="80259" checksum="4B6B654278E73046" modified="2017-01-18" version="1">MPSAAWKSSFRSPSPDTDSEDCLPSQFAASTHADLAYDLDLSLRQDHAELKSTPFTIAKQKSARKGGRKISNLVTAEDRRNGVTSSPSKSSTTKSSNSRPVLNNQTLPFQPQPRKPGPKPAKKDFVQQPLHDTPPKPKNRKKPGPSAAWVDKDGNALPEDPPARLSILEVLEEKEKEEEKKVKKREAAREKRKRTVEAKKREKEGNDKIQFHMLPKGAATNESFPIVRALQKQQSLPSRTRPLAATSIRLNEGEVTRSPEPENLVDATEIDDLVYGPKGARGGTTVEDAIEIASTPTLNRKAEWSESIRTTPTLVGSDSRSAQRHHDLPFAKTTHRVTPSSRSTFKPPFKKPFVDHVSPQNGHIDPHSSSEPHLSTINQVPSSLSRGGETMTSGVSKLAYSSPLTGRGRAGDSVAHVRAMARASDTKGRKVFEEDDVYVKEEEDEYRSADVLRLERAAEDFHIPPAYQSALPPNIARPVARRFQPPIPVVSKSTLNQDRNSPPPIRSSTPEWSTLPAKRRRDSSFNSPNKNARQPVVAGRFRMPASLFPTPKRTAPSSPSPEPAINSPPRKYSKLTLFTPSSKEDDALRPERPAYTVRTIRGSKFASSAERNDSYPGAGVKGRLTLPPRKTGSSTTLGRREPERDYSPADQRAGQSRYDPFQSQYRRYDTTGEEEGDEDDWTSAWRGKESANVGAMGGRDWVDEDELEAAEKYVFQRRNGYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMK3</accession>
    <name>A0A1E3IMK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029554.1">
        <property type="nucleotide sequence ID" value="XM_019178398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMK3"/>
    <dbReference type="GeneID" id="30195544"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10391" checksum="E494365509E38B53" modified="2017-01-18" version="1">MTKGTRFLTLAIPVLFIYILALYQIIPVPLLSSQSAEAVLPVLPWWLLVSFGSYSLSSLGLGLVRFHDTPEAYESLLGEISQAKNELRNAGVAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMS6</accession>
    <name>A0A1E3IMS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029634.1">
        <property type="nucleotide sequence ID" value="XM_019178478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMS6"/>
    <dbReference type="GeneID" id="30195631"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="397" mass="44265" checksum="5832D691692AC1E4" modified="2017-01-18" version="1">MPAVPLDRKAMPDKLTAPPLAKREEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKQNREKMTQIMFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFSIPHSILRIDLAGRDLTDYLVKILMERGYFFTTSAEREIVRDIKEKLCYVALDFEQELQTAAQSSQLEKSYELPDGQVITIGNERFRCPEALFQPSFLGLEAAGIHETTYNSILKCDLDIRKDLYGNIVMSGGTTMYNGIADRMQKEITALAPSSMKIKIVSPPERKYSVWIGGSILASLSTFQQMWIAKSEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPN3</accession>
    <name>A0A1E3IPN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atypical/ABC1/ABC1-C protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029560.1">
        <property type="nucleotide sequence ID" value="XM_019178404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPN3"/>
    <dbReference type="GeneID" id="30195551"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="5">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="698"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="770"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130229" checksum="247AD57932CD2515" modified="2017-01-18" version="1">MLLRQPGVARRLCPRTLKPPCATRSASSSAPPPPAGEHLTGSAKLFAEADSEESLGTTDRDSLRHTQGPVWTGDESTSDAVLRMLVDANKPLRNPGGIKHNAADDKIKGWMKGLKLDARLGPGVELPLKSSHEEGEENPHRTRLPPHLHRPWHSTYTGEKAAAEEPNIKYGAFIKSKRDGDSLTNLLELQLPPGADGKTRARVKESRRTGKVIGRLDNAREGALDYKLGLSGKGPLLVDLGEAEDWDEGEGEGQAFNGNRQIKGASVLGAGRGGASGLRAWQGLVEDRIQRAKGKSKSPSARDPADRSADAGFFNTTTGKGKPIALDPEASNPYIERGELFMNRIVKRQGALPPWIELLNHLDSSLNAFRSTLLTTYKTHIVRQVISSTSLHPLPPLHTIPERDGTWEQRELKFHQENVKQINDLTRRMNAQAPAPARRNLITLENELDKIRGEVIKTAVWEDIKKRAEESVDQSFSKQKTGFTPFFEGEGWKAFKNVTRPFGTLASSGMPAASNSNAGGVSGSSREYVGDHGEPSGHGGARDPKPMRLAVMAGVGIGLIIYLRQRTVKADDLSSAPQPEKDTIVASSPAEPPLTVTYIVQEYIIEPIATLFRFFQLAALFLPVVILSPMLLLGETRKRRQLGRAIGEDEANWGAIWWYELLVKQMERAGPSFIKLGQWAASRADLFPAELCEKMGKLHSNGKPHTFDYTKNMLEKAFGKGFKDIFEEFDENPIGCGAIAQVYKAKLQPELFANARGGGGDSSEPLTTPSVAIKVIHPRARNTIRRDITIMSLFARFINSFPGMQWFSLPEEVTVFGDMMQSQLDLRVEANNLDTFRKNFKRRGRRVTFPTPIKLGQGGGEDRAGMRDVLVEEFEDALPLKYFLRNGGGPYDHKIANIGLDAFLEMLLLDNFTHGDLHPGNIMVRFYKPTTTDYLAPLLSHFGKGETAAPSQETVSSGEDIVHNFAAISRDPETWVSRLEDLHDQGYEPQLIFIDAGLVTTLDNTNRRNFLDLFQAVAGFDGYKVGKLMIERCRTPEFAVDEETFALKMQHIVLNVKSKTFSLAKIKISDILTDVLKAVRTHHVKMEGDFVNTVISILLLEGIGRQLDPEMDLFKSALPILRQLGKQMGTREAISATPTGNILAMIKLWVWVEARQVAGEVSTLDQWIKYDRLTPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ32</accession>
    <name>A0A1E3IQ32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAT family amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029815.1">
        <property type="nucleotide sequence ID" value="XM_019178096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ32"/>
    <dbReference type="GeneID" id="30195241"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="63"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="571" mass="62482" checksum="0BD51DB21DD97975" modified="2017-01-18" version="1">MSEFKEYGYGYSNDNKKAEDYTTTEVLAADDIDVESPGIDDVPHDDDGLEDKYKLKRGLKSRHMQLIGIGSAIGTGLFLGTAPALADGGPLGLLLGYALMGAVCVCLMVSVGEMIAFYPVPGGHIRLAERFVDPALAFTMGYNMVVSSFVSLPSELSAGAVLINMWNTDISNGVWITCGLLLVIALNLFGPGVYGEAEFWFCSIKVLCVLGLMLLGIILTAGGGPNGEVIGFKYWKDPGAFVQYEGISGSLGAFLGWWAVLLRAGYAYLGTEGVALAAGEARNPRRTVPRAIKTVYVRIIFFYIVTVFLIGMVIPSNDSNLSLSSGNALSAPFVIAIRRAGIPALPSIVNACLLTSAWSAGSAGVYTSSRSMYGLAKLGIAPKIWMRTNRYGTPWVGVLTVGLFGGLSYMTLDGTASEVFNYFTNLTSACGLLTWWGMSFTYIRFNSGLRAQGISRSSLPYAPIINYRALAAWFSLFWCSLILFFSGWSNFLKIDGESNWSTSGFITNYMPVWLYPMWWIGYKLVKKSKFVRSNEMDFVTGIAEFDVQDYKNEAEMAEKKPWYKRVFNVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRB2</accession>
    <name>A0A1E3IRB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029773.1">
        <property type="nucleotide sequence ID" value="XM_019178335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRB2"/>
    <dbReference type="GeneID" id="30195481"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129906" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="477"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="662" mass="69614" checksum="C44B4F6FF4B8A088" modified="2017-01-18" version="1">MFPSLALLPLLGFLALPLARADASVTLYTGASATATATSLAAGETYTGLAAYDPARLTAPTPPSPAVTSITMSIPSNGDGVVAENLALSIPQKGNFLGFSIELSVAPSIMGARSGTLKVPFLNFMANIQNRAGVGAIVRVGGNSQEGSTIFVDGLDEGAAMEKIKVSSGATDTPIINYSPELFYIMSNITSLVGVEWYFGLAFNETDVDLQIDNIPLAATWAQEILGDSLLGLSVGNEPDLYVDHNHREAGYNVADYISEYDATLASIIANGSLLDPSIFLGPSLCCEVAGFEFSDLLSAGWLDDNVDRLSAVTVQHYPTNNCQVNGNVIDAQDIFADFLNHTSAQALVGAYLGDSATVQDRGKEYVMLEMNTASCGGFPGLSDSFGAAMWMTDYALQMAYGNFSAALMHVGGQNVYYNPFTPPPSSLSSTRQWTPGSVYYPTLVVAEAFGKSNNSRVVDLTPLAEVDANYIYHPVYGIYEDDVLARMVLFNFIDDATGGSDLDIVINVQNQGSPSEVYVRYLQADTVSEQYDIYWANQTLGSSFAADGRLSGDQTTYQIACDQTANTCTIPVFAPSIALVFFSNDFLEESSVAEDATSTYGTSVVGSGDATVDVGSLETSNGGTGNQGGGTSKGNQTSGAGRVAVGAGWAVACLGVVSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS60</accession>
    <name>A0A1E3IS60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030070.1">
        <property type="nucleotide sequence ID" value="XM_019178031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS60"/>
    <dbReference type="GeneID" id="30195172"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="237" mass="25933" checksum="7B932EA2CD7C5C97" modified="2017-01-18" version="1">MTDHTPRERFEAASPWLASAPAAAGLPNETKLELYGLFKFITTNEGPSSSRPSIFYPTNRAKFDAWASTFKQYTSLNIEPADAQARAQGRYVDIAKQVGWDGVIREEDDIDLENLSDSDDEGDESGKGGSGKDGWRSVSVMEGAGKKSAEDPIHDAVSTNDSVEVRRLLQNDKGLVNAVDEFGYTPLHLAADRGYPDMTRLLLEHGADRSVKDQDEQTPLVLAEISSRDDIIAILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITV1</accession>
    <name>A0A1E3ITV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030126.1">
        <property type="nucleotide sequence ID" value="XM_019177742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITV1"/>
    <dbReference type="GeneID" id="30194876"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="416" mass="45882" checksum="8F7E7DEBE4ACF98F" modified="2017-01-18" version="1">MSLRDSSCYTLTICPHSADPAVVELVESFGPTKGGEEPRYARVKEAQAGEGYSAALYDIVTGARLASAGYVVEKAKSRRLQLHGPDETIPFHFIGKINFEWTFVFQGNKYSWRRELYGKDYICTLNRKPDPSVEICLAREAYKRNPARLQILHYNIDRFTSDIKDVRGLETLLVTSLLCLLDAWEDRGSLTNAKSGPSPPIKESTPVDPALAKENPNEILVGTHTNMDDHVARAVNLLEDPNILFIIIRTKSSDAHQRALQVSLGVKRFRHRENMSDLHQYIIEEEDTAQPVSSSKGPKVIDLNDPKPVPRPTSSKVWTPPTRMAIYLSTIVLPDLNPSRMASTSKESAGNSRIQSNKMGEHAGRAPTKPPKPGHTLPGSTLKTPTPPPLTEADSGGSGSGSKSSLRNSTFGKLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU48</accession>
    <name>A0A1E3IU48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030226.1">
        <property type="nucleotide sequence ID" value="XM_019177842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU48"/>
    <dbReference type="GeneID" id="30194976"/>
    <dbReference type="OrthoDB" id="2576311at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129955" evidence="3">
        <location>
            <begin position="37"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="62714" checksum="A39CDEE7D7D9303F" modified="2017-01-18" version="1">MRAWSGDTSPSARFKPDSQLLLSLLLILPCLCGVAAQTSNATCEQTDENEWMFNSDGESPCLVWSKIQSLCVSSESFINVPPLLDPSWSYNAPSEASSECYCNSVSYGLMAACTYCQWSNSSIPSEESWASGCQSYNSDGLGFAENVEDIPPFAYQTWSGAAWAAATVSSVTTGPSSTPSYSTTLSRSFPTSNNPFSSSSASTGDSLTTKTASSTSSASSSTATSSDSSSDDSEGKSSTPWGAIIGGVGGGVFGLILLFLFWRWYKNRNRISNPRSPFSSPHDGTAQKRTKKARVKYPLPPQSFRDSLAAGKNFLDMLVGGGSGIEEKGKRDTEMMNDPEAFSAPRKAPPAPRSQAGSGLAWKTRSKSLRDEDWSQSDQEYDENADRRGTKRITWVEAFLPSARAEKREREKEDMRYTTTSQRLARNTLTPSEMMEEESEAGMESARGDSPTLPVRARYPLPPAPPPPAHIPPPAPDQLPLDFSQAPSRHPSLRPVSGNTLPSLYEPPTGARTYRGSTMYSPASRYPGNAETMFEVHDRGRERPMSESTIGAALNSASVHGGGGWGRDSAPPLPTPHGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU60</accession>
    <name>A0A1E3IU60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030288.1">
        <property type="nucleotide sequence ID" value="XM_019177904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU60"/>
    <dbReference type="GeneID" id="30195039"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10587" checksum="3DCB29C28722BB69" modified="2017-01-18" version="1">MVHTIIAHFHARPESAQEIKDILKEGAALYVKDKGTINWYVMHDHEDSTKFYAVERYESRAAVDVHINNPHFCDFVGPRLVTPMTITQTEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUH0</accession>
    <name>A0A1E3IUH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029987.1">
        <property type="nucleotide sequence ID" value="XM_019177948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUH0"/>
    <dbReference type="GeneID" id="30195084"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="89"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN91361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="413" mass="45732" checksum="BB5540F112674106" modified="2017-01-18" version="1">MSFALRARGLRAATRSAALKPLRATLPHVRYVQMDADKSSPLVSELPASGSEQFKVQLHSETFHSYRCDAPAPETTVTKDELVHMYHTAVQMRRMEQAADALYKAKLIRGFCHLAIGQEAVSVGMELGMTREDKVITSYRCHTQAVLRGGTIKGVIAELMGRKDGMSYGKGGSMHIFTPCFYGGNGIVGAQVPVGAGIALAQKYLKKPTATFAMYGDGASNQGQVFEAYNMAKLWNLPCVFVCENNKYGMGTSAERSSQNTAFFTRGDQIPGLQVNGMDILAVREATRWAKDWVVSGKGPLVVEFVTYRYGGHSMSDPGTTYRTREEVQAMRSSQDPIAGLKKYILDWGVTDEASLKAIDKSAKEEVEQAVKEAKESAFPDLVEFWQDVYYKGTEPGFMRGREKEEVHYYNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVU4</accession>
    <name>A0A1E3IVU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030344.1">
        <property type="nucleotide sequence ID" value="XM_019177593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVU4"/>
    <dbReference type="GeneID" id="30194724"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN92717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="37156" checksum="D47C0C48D48C3320" modified="2017-01-18" version="1">MSASVRTVKDGDYDALREEIGKIMKQPGYDDGSAGPVLVRLAWHASGNFSLVEHNGGSNGAGMRFPPESVDPANAGLHHAISFLLPIQAANPWISHADLWTLAGVTAIEHMRGPRVPWTPGRSDYASEQEASSHRGNVGDRLPDGALGAQHVRDVFGRMGFTDQEIVALSGAHALGRCHKDRSGFDGPWVVNPIRFSNQYFKLLLRPIWKPREWDGPFQYEATVAGTKLMMLPTDMALVEDSALKEWVEKYATDQDLFFKDFANAFAKLIELGVDRDDTGLASLAKKAAEEGKPLDKTTPPAGSSAGNRTAKLGSGGCPFSGANGGVRMAGGGCPFLAGQRKSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW07</accession>
    <name>A0A1E3IW07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030431.1">
        <property type="nucleotide sequence ID" value="XM_019177680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW07"/>
    <dbReference type="GeneID" id="30194812"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="265"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="359"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="363"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="480" mass="54277" checksum="B4CCE31000C9B954" modified="2017-01-18" version="1">MTMFADILFQNPATRRPATRSRNDENAAPQPSIRNKPSLSHLGPAQKTAVSGASAAAAGKKPVAAKVGAKRTALGGVAVNAKEDGVEGKKPLKATAGKTVAEVRQPLASRNNDAQSARPIAAIPSRSKTSAPIYSSLDSKLSLEDDFQMEGDFRRQQTLSVPQGIDTVEEEYLDEDSEEDDMEEEDEEDWLRMPEEDAIRAQEQLDVIQATFKDEVDLFDTTMVAEYADEIFGHMEMLEESVMPNPRYMDFQTEIEWTMRTTLIDWLLQVHLRYHMLPETLWIAVNIVDRFLSVRVVSLVKLQLVGVTAMFIAAKYEEILAPSVDEFVYMTENGYTKDEILKGERIILQTLDFTVSSYCSPYSWVRRISKADDYDVQTRTLSKFLMEVTLLDHRFLRCKPSMIAAIGMYLARKMLGGDWNDAFVFYSNFTESQLITGASLLCERLVEPDFESVYVYKKYANKKFLRASTFARDWALNNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW45</accession>
    <name>A0A1E3IW45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acyl-CoA-dependent ceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030409.1">
        <property type="nucleotide sequence ID" value="XM_019177658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW45"/>
    <dbReference type="GeneID" id="30194790"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="174"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="48130" checksum="48769A35C517B59F" modified="2017-01-18" version="1">MPTSSKQDTHRRRSSSVTAALNQIPLNQQGDGILPLRVKSRPSFHPVLGTPSKVKARPLSRRYVSDGLWNDVKTGKWLLIPSSSLKLSLIAPILCLLHVGLAYVGVEAFQPGGQIPNIGAKCMLPSNEQDGGYAKTWWDVALLVHYIVFWTFVRQFMTLKVLAPLAFKLGVRGGKITRFTEQGYAVFYYGIYVTYGLYVMRSLPTWYYKTEYFFIDYPHKIMSFRLKFYYLTQWAFWAQQTIILAAKVEKPRKDYKELVLHHIVTIWLIFWSYMAHFTYFGVAIFFTMDTSDLFFSLAKCVNYVSDFWSIPFLVWFTIAWTYLRHYLNLLILYNLPTQYDLIPVAARSKIDFFNDSYLDSYGFMKWQIFIPIALLQALNLFWYFLILRILVRAVWNWGEDVKDDRSEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXV6</accession>
    <name>A0A1E3IXV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030555.1">
        <property type="nucleotide sequence ID" value="XM_019177402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXV6"/>
    <dbReference type="GeneID" id="30194528"/>
    <dbReference type="OrthoDB" id="2568499at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21469" checksum="1945A78E0BFCD3DB" modified="2017-01-18" version="1">MSSTTTFNSVVHMFGYPSSLTAFTSHWLPPLTTTTCFNIATAAMVLSAITLREMYSEANSLFWVSTLAEADVAFVRTEIFRNLYILSSVIITTLDISHTFTQNLPYSASCGVIIRLAIVCACYSRIALSTKYRNQFPQGPERQTVPRRDDKISMDRVQRERKSGMKEPVGFWADVYGLVASWGAWKKRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXX3</accession>
    <name>A0A1E3IXX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030572.1">
        <property type="nucleotide sequence ID" value="XM_019177419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194545"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="581"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="685"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN93467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2294" mass="250857" checksum="208E6F7547CC152E" modified="2017-01-18" version="1">MLGVSSTATDNDGRRALGIRPGGHPLPRLQIDPNPFVDNPPSPTLDYPPSPLSTSSSRHSSSPQALRSPSSPDISKLSSRRATLGRRPTISARKAQQISNYRGLYETQKLLSHLLDKLEQREPAPDILARAVIAARQASGLPKGKGKGKVLKMGQALAAAATHSGSAAHKRHVSVPVGGIGSEDFQEQIVLDEGDWDTEATFNLVQQTRDLFVLAERQDLDLFAENGEADRPILDATPVKNKKGRAGRFSSVAPSASKGSNAMSYEADTSMASTSVPRASTSTIPSMSGSYLLERALSALHSLISIDCLHRTHLFHPLCPPNALQAACLNIASYLYMKCDVETKVKVVGMVVDGLYGMGEGMGEKVYEWLEGRMENLLRILAKERGEVSDKKEANVDWIDPFSKPPSTTTDNHLPTFAISTESPDMENTNSTGPGWKQFSPTSPQFSFFPDQLPGLLSIQAMRDASPTAVQIAALVPRILMAISSTIDLAGSKLTMIHRVHRLLTIILSAKPDSPLDLLSIIAYAPPAPRRTATELLATFYPNVMGHNTIARRLASTTYASQRTKWETGQFSALGEDDTEGHHFVPWRISSKEHSSLEAIRCLVCEGEIHGFGIRCTMCREHRHLRCYTTARSSRGPGGFTYDVMIITPTSSSSHLVHVKFGYSAPTLEEELLPPRFTAVRKAGQHTLRLVNLFTLSLCGECRLPLWGTSRQAYACESGCQRLYHAECLGHMDNSQCRHGKEVVVDEISGESNNPFTITPESLDQDFSKHCQGLRLSQSEMESVSFDEVAVLFGALWLQYQLVKNGLSTGSLRIAGEASSSDGKTKTTDPLNLRPVLKMYEDYLQVQEEEVSGAMCDFKHVAGLEKPLGTGYLFSEKFLAYCTALIRAPSSELPHSHGNPGEGLLTPQGLPAPNNDVFEEEAGNCYERLPLSFIYETLKSDLFLTSPYSLAAFVNQLIMTGLISLPPHSPLRHDNLSQSQQNQASFSLPLLMDSAPTTELLVLAIESLLDDLDLTMNEQGLRLMVDRAWPSLLCAPYALERLGKAAVGWIMAEEDCLRELITSYASKHRRIPGVRPSPGSLKGSIDAYKNDRQQIRSTYVRDWCKDLHDQDPGMYAHIVYEQCKLAAGNAAAEDSGGANQQQMASKIAGIAANKMAVMAEAGVLFSTVMELLTAWLEDLGPLADHDVAYRSLPRLLSHQPSDSPDIFALSASTTMSNPSDFARVCRWMRVLSFSGAEIPWELLQVLIDQQVEFGVDVPPEASLDLVIAVSANGAPLEPKMFAGLCSIMATTVFDNIDPGPGDLSRLEFELIKRTMMLILKAYGVISEDVSDTVLGGIGQQMKQSMSMGKRRGTMFSFVRFPLDARMTLAAADLLKRTTCPCEIVLDFIWLLSTKAINVDDPVGFLHHTCERLYVIFWPLIARPVSRRSRARVLLRLLSVNATPLVKLIHAQLDTSREERTIVRERLLTLILELADSSINHDLVNWRSSAVALILVFFDVLLDNREVIPDNLVVHKSLLPTHLKAISLCFEEYLVKNSDENRLVLLTRLSRLRLALPQWAVISWESIEEILAEEVTSMSQFQPARKSSADTGLTDSEDVTYALAALGLEMLASGVVVSWVTAQRFQQRVVALASASSASPSAFTSTMLPALRAVLDSPAKILITGHTFETKTRNTASVGSLFVPVAIDLVDDLNAYDHPTQRLLLDVLMVVFFKQNVNRVELAALTCVQQVADFVSLNDCSENRLLGIQILQTAVEKVDRDKIIRAVPPIFNTLALVIANEINAEYGDSAVTDQTSDDPGYTYNCSGQNESERQSLSPKPATESNLCKALQILDAAEQAEGLAQVGIFDNLFHDLLDLTRRPRDQIIQILESFARLVAELCIDLTVEAANEWGYDYDPNPMLQSCAKVMDLSPSSTLVPLLSQIATILNQCLCHFGVTRQTTLKLLGAGQRAGARAGVENQIKSVLLNVASTAVDGLAVPPVSLHALLKLLNTDLFPQLSPTSKAGPEHHRVLAESGSGCGNILFRGHQTMTSALLTAELLLDILVEAGTLLCQGEIIIPGTIGRNLTQLTMNAASIQLRSLLFLLLASTNVSMGTSRSRLFALYPLLARATSLSLRASADYMSIQDVEGTGASILSLVFMTLRVAFLAVTDKAAMDAGGIFESQKDDVLDEFWARVWPDWNRLFALSFDPKCINGALRSVTHSVFLDLLVFLGAVQSPILIRHGEALTVTLAMLAKYQDSQGTTTTAKMQKAGLVVEKAGILGLGSNVMVNTAAVLKQLKEDLLATERIQVLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY50</accession>
    <name>A0A1E3IY50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stromal membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030453.1">
        <property type="nucleotide sequence ID" value="XM_019177702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY50"/>
    <dbReference type="GeneID" id="30194835"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="44958" checksum="3ABEB505B7581EA0" modified="2017-01-18" version="1">MSRQDKATTERNARILRDLVKQPENKSCADCKRNDTRWASWNLGLYLCIRCSGIHRSMGTHISKVKSIDLDIWTPEQMENIQRWGNTRANRYWERHLKAGHVPPDHKIESFIRSKYESRRWAMDGPPPAPETLDSDTSSASAPPPAPASRPTSSAPTPTTTAAPPVPAHLPKTHPLLSRSVAANKASPSKPTPAAKAPIIDLIGDDEAPAATTAAAPAPTQAPAPTSPAPAAASTGSSIFDLDFRAPSATPSSTTSPISSAPAPRSAKADIMSLFSTPSPSASASASAGPNVAGGFFAPPGGVQGQSQYANWGGGVTSSAPPVQQNPTQAPVPTQSNLWGGFNDQAAWGAPQSAAPQQQQVQVQPPLYAQPQQAQQNVSANPWTQAGGASDPWASNSSGGGAGFFGAGSGAAQAQPLAKKDDRDPFANIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY82</accession>
    <name>A0A1E3IY82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein CWC15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030637.1">
        <property type="nucleotide sequence ID" value="XM_019177484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY82"/>
    <dbReference type="GeneID" id="30194610"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29196" checksum="FB7243D244B04812" modified="2017-01-18" version="1">MSQAHRPTWNPTQGRETKSGSQQISKLSLAAHTKLKFRQPGQTNQGDVVRRDLKAELAEAERKAADKKRKAQGLPALAPGPEGQLRIEGNGEEDEAAVKRRKVLEQAAELDKDDESGSEDEEEAPKDKGKDKAVDNEDEDSDDSDDDSDDEDDTAALMAELAKIKQERAEEKARLDEEAAAKNAVSREAEIATGNPLMNLQAALGTAPDTPGSTTASSVSGGFAVKKRWDDDVIFKNQAVGIDDKPKKGEFVNDLLRSEFHKKFMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J015</accession>
    <name>A0A1E3J015_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030748.1">
        <property type="nucleotide sequence ID" value="XM_019177167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J015"/>
    <dbReference type="GeneID" id="30194284"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="614" mass="67091" checksum="6EAA99806A5E6DBB" modified="2017-01-18" version="1">MSAEDVYEGAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTEGERLIGDAAKNQSAMNPRNTVFDAKRLIGRRFDDADVKKDMKHWPFAVVDKDGSPYVEVDYLGERKTFSPQEVSAMVLTKMKEIAEAKLGKEVKKAVVTVPAYFNDSQRLATKDAGAIAGLEVLRIINEPTAAAIAYGLDEKTKEERNVLIFDLGGGTFDVSLLTIQGKVFSVKATAGDTHLGGEDFDNNLLEHFKAEFKRKSKHDISEDPRAMRRLRSACERAKRTLSSVTQTTVEVDSLYSGVDFNSSITRARFEEINAVAFKSTVDPVEKVLKDSKIPAAKVDDIVLVGGSTRIPKIQSLVSEYFGGRQLNKSINPDEAVAYGAAVQAAVLTGQTSDKTADLLLLDVAPLSLGVAMQGDIFGVVLPRNTPIPANKSRVFTTVEDNQTTVMFPVYEGERTQCKDNRLLGEFELSGIPPMPRGQAELQCTFEVDANGLLKVSAQDRASGRKAQITIQNSVGRLSSEEIQAMIKDAEQFKNADKDFSAKHEAKSDLEAYLHTCEQSISAPELSMKIKRGARAAVESEIAKALEVLEQEDATADQLKKAQLGVKRAMQKAMASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J058</accession>
    <name>A0A1E3J058_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030641.1">
        <property type="nucleotide sequence ID" value="XM_019177488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J058"/>
    <dbReference type="GeneID" id="30194614"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="31090" checksum="6E6A4C3E061622D5" modified="2017-01-18" version="1">MLELAGYDLPTFFPHVGPLPAYGPFWNLDVGRATKGHDLSECVKQYTAAVAQSVQTVVELYRSEIKLLRDQYQQEAGVKLSEQDALSAWWIYLIKKVGVDDVNTVIYICNYRSFSPEHPSFPPNLSTLASNGAQMRHIPIPPTSSPSASPALVAKAIREGVVKLRYSSDETLRWIATVAYELRKAAIEEKGQIVLPRPGEVSVNSNMRMDWNVSYGFPTHQVAFHTVFSVPRFLRVFRANPREGEEKGKRLELIFNVADEGVKRKVQEAVDEERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B8</accession>
    <name>A0A1E3J0B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030815.1">
        <property type="nucleotide sequence ID" value="XM_019177234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B8"/>
    <dbReference type="GeneID" id="30194353"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="266" mass="29621" checksum="C66BA8A3BD0B504D" modified="2017-01-18" version="1">MEVTPQVLVRHIVDQYKELPENKRLLIAVAGPPGSGKSTLAYPLTDALNALILHHPPPNPSHLEEPASNLLAESSDQHGQGDEVAIAVGLDGWHHTRAELDAFPDPVEAHWRRGAAFTFNRPSYQAFLSQLRVPLTPEPPAAIPFPTFDHALKDPAISPQPILPRHRIIVIEGLYTMLDEPGWSETAEMMDVRIWVDVDEEVARKRLVDRNLAAGIVDTREKCEARVDASDMKNGEHVRSRLVQPSYTFTSIEGQPFTSETFRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0D2</accession>
    <name>A0A1E3J0D2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030864.1">
        <property type="nucleotide sequence ID" value="XM_019177283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0D2"/>
    <dbReference type="GeneID" id="30194403"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="239" mass="26152" checksum="C0C67797588D747E" modified="2017-01-18" version="1">MSQITVQAWETNRADSAIPQSTNDDITQTVNGIVEYDLPKAETRHPSSTLPGQRYGSFTIWSHSRHDLEKSRILRGSFVSGNALPGAASSASKVDVDNVSVANELLSKITATLHEDGGWLDDCCTQQSARPLKEKEESVYHDLVNEDPERYRNIGLRRTDRDTAQDVLICQYMSTKATHHLSQGGVDQRVVWLSPDDETKTYVYLPGSMVVPAGTTGHDGRGSGSVIFRETSTTAGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1F4</accession>
    <name>A0A1E3J1F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030999.1">
        <property type="nucleotide sequence ID" value="XM_019176967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1F4"/>
    <dbReference type="GeneID" id="30194076"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="90939" checksum="BA4969FFD9A38124" modified="2017-01-18" version="1">MSATPPGNIKLPSRPTPNDILGGSALAVETPSPAHVHGSNLDTASPNDAGFSRGTVPRPKGHSRASRPSFGSYGRGHRLASSRGTPGGIVDELLDEVEAAPKLPSLVPGIRPAYSTPLPVLPIAVLCIAMSSEMLAANLCTPFILKQVEGFFYSAGHEKSSDTEAAVGLWTGNLVSVFFITQFLTSLLWSSIADRHGRRAVLVASLLGSCIALVVFGTSESLPEAICVRLVQGIFGGAVGVFRGSIRDLTDETNASRAYAMLGFAWSLGGVLGPLFGGVLESPEYNYPGTFLARVVLFQEFPYLLPTLVGATILFTGAVLSCFLSWDGGVRGGRRIELQVEKDEPLVAPSSPDVVQHSSPAPSSRTAVRIPSTNFRRGVTSPGEEEMAVSHGGGYPELGKSAGTRRDSRASVGTAYGYGGIRSKRPTLAARAALEAARRVSTAVHRDDSDDEEDVKGNKALRVAQKLLLANEENTFNINDLWVSAAVAQDTAVFDDEEEETEEEHEEDDELLNDTSAAASPSVGGASPSVSEDHRGSLGFGLTHRTGRVTSMGNMSLHRNLPGHRLSMSGRRFSTTSGHMPAIFSNTGVRTPPAVTAAYNAESPRTEVDPFFQGSPAPEHRAQGGLAAIAEAGSNAVDTAVTQVSEKMPSSFALLPVQMIVQYGLLALHNTIHDQVFLSFLVTPYKSGGLGLNPAHFSLIISLMCLCQLVYQFYLYPRLGPPLGRFTHLQMFRIGCALYVPSYLLLPLLHKVASAESEGGFLLMVGLVMVTALRYCAGTFAYTSVMVLINAMSPPQVVGLSNGLAQSTVSFSRFFGPVIGGAVWSASINGNPNGYAFGFYFVTIGCAIQCALSLLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1I1</accession>
    <name>A0A1E3J1I1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="14" type="ORF">L198_04825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030963.1">
        <property type="nucleotide sequence ID" value="XM_019176931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1I1"/>
    <dbReference type="GeneID" id="30194038"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000363">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="74"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="395"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="596" mass="64162" checksum="3F43B6BC1AD86B19" modified="2017-01-18" version="1">MRPPATACLKNLRTPVVGRSALPAASRHLHLVRPPRLTSRAVAQPAFRVERRSHGHKAQEVQGPIPEISKEDTYDIVIIGGANAGLALACALLSHPTLSTTTRVLLLEGASLDKTRTWPQSEEWENRVSSLTHESVEWLESIGVWKHIVENRSRPVYEIVIWSNPSADSNPTIHFPLIGRPLARMTENLNLQQALLKRINEIGEGIVDIRENSRVGEMRLGEGGRWVGLRIGDEWIKGSLVVGADGPNSPVRHFSGIDSYGHAYNTHAVVATMHHTASPFYPNNTGFQRFLPTGPIAFLPLSETTSTLVWSTRPENAAALKKLSPESLTAMINAAYALPEETLGLLVEEVLAANEVGIPLTTERISTLIATLPTPPLSADQPLLPPTITHLHAPSIASFPLRLSHATSYLGARTALVGDAAHTIHPLAGQGLNMGLADVRSLAETLEASKKVGGDVGSLEGMKGYPKERYPLNHLMLSTTDKLHYIFRARNPLINWARSTGLDVINEIGPLKRLLMGGAGSGVGPFSTGGRSEKEREFGRSEAGESMKSAGGWQHGLASAVEGAFVLKSVAGMVGGVVGELARNGLRKAADAVQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1S3</accession>
    <name>A0A1E3J1S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031057.1">
        <property type="nucleotide sequence ID" value="XM_019177025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1S3"/>
    <dbReference type="GeneID" id="30194135"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="253" mass="27214" checksum="E661E33C87C74684" modified="2017-01-18" version="1">MQSQPAASSSSSTVPSHADRLYVGNLAPTVDEYTLIQVFSKYGKITKMDFMFHKTGPLKGKPRGFAFIQFSDKGDALKAMVKLHDRLLRGRKLVVTFASSAPPDNTMLQTKGRRAEPPKTTTLSLLKSRRKPQSAEAQIAAMEAKLATMAQQRPAGDWTPGSDLNSPALGSSASGSPAPLDVPMGEEEGKRAALELEREIQGELGQRKESVNGAEGDSGSSTSNHSVEHAEAKKDTKDPFRRGLASLPKKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1T0</accession>
    <name>A0A1E3J1T0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04956</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031088.1">
        <property type="nucleotide sequence ID" value="XM_019177056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1T0"/>
    <dbReference type="GeneID" id="30194169"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="143"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="56085" checksum="AB0AD5836EC25E22" modified="2017-01-18" version="1">MSQPPPSSWADDYEDPKPPPVQMSTQNDGWGEADATSASPTDPAPAPEAPQDAWFDASVPQSAAPPQADHDPREIQLKDDTQNLITNDFQVEVKLADLQGDPNSPLYSVQSFKQLNLHDDLMKGIIAADFQKPSKIQEKALPLLLSNPARNLIGQSQSGTGKTAAFTLNMLSRVDPTIPTPQAICIVPSRELARQTQEVVDKMGQFTQIGTFLAVPGSWSRNQRIDKQILIGTPGTLVDMLMRGNRILDPSMVRVLVLDEADELIAQQGLGEQTFRIKQLLPPTIQNVLFSATFNDDVTEFAQRFAPEANQIFLRKEEITVEAIRQLYLECDSEEQKYEALSALYDCLVIGQSIVFCKRKVTADLIANRLIAEGHAVASLHGDKMVQERDAILDGFRNGQTKVLITTNVIARGIDIPQVNMVVNYDVPDLGPGGSGPDIETYIHRIGRTGRFGRKGCSVIFTHDYRSKSDVEQIMNILGKPMKRIDARSTTDIEQLEKALKMAMKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1U3</accession>
    <name>A0A1E3J1U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031077.1">
        <property type="nucleotide sequence ID" value="XM_019177045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1U3"/>
    <dbReference type="GeneID" id="30194156"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="721" mass="76124" checksum="D97263198FD4A012" modified="2017-01-18" version="1">MVSTRSPPPSSPRSPKSSKSPFPKPADSFAPLTSVLADKAQPDAAHPIEPKAFLLQRVLSGGSTATTATSESGTASPAMKSVPLSPSSPGTRTPRAGQQQLAGDMDGLNVRSPISNNGQLPGEGILGMMNAVSETPEEMAVEPPSQEPNGNDGSNGKEIGVGRNGHGVSRSYSSSTESSSSQHPVPPSYLGSSYGPEGFPISQSPMDSPMAYPSYLASGLGYFGNGNDPDVAAKQAAALARADEAVRQLNNTSTVIQGPTPGLPYPTDNFAIPRNYTNFVTPQQAGPPVTRQSSTSSSTDAASTSSEESDWCIPSIEWVPAHQWQQSNYLNSPGSQFARDKERTASFSCMPPPSSTKPSSPRRPSADRSIQHRNSIPVGASAGTPPPGMASRPSWSASTAASSEPPEDDDDAATVGHAARERSHSTSSQSAQSGLDLLWRAAHGLPHASHVGTPYDPAFEHKGKRKAGAEAVDKWRASGIPTGVPPGGDAEVEGSTPPVPGPPRKRRRSEMELEPMDEDLEEVDEDEPIKEELSDYHSPSTSEPVPSDHDSDYGGSSSAPKRGKVTGRGRGRPKGSTAAAGGPRGRTLASKVDLATAPGGVTKQGNIKKVRKVGDMPNGLAKGPSKEAVHVPPGGVQCDYINPLPPYNRCTDVFTRKYDLPRHMARHARREGELVVEGALDNEKAVLWRKFKDKPKVQCGTCGESFTRMDALKRHQAKQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1X8</accession>
    <name>A0A1E3J1X8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030944.1">
        <property type="nucleotide sequence ID" value="XM_019176912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1X8"/>
    <dbReference type="GeneID" id="30194019"/>
    <dbReference type="OrthoDB" id="10300964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="682" mass="76827" checksum="0EA700D5DF2B5129" modified="2017-01-18" version="1">MPEGFQLDLDQGDGIPRTVNWTKENYPAFALPEIEAHYLQLANLDHLKKELEHTVATLDRLSRKGLLDPTRDYRTLTNLAAKSLTNAAGSLISKDPDAVLHNGHREWNAADASRWANHVHLEADDLETRGHIYYGNKTQNDTEEDANEEVMAHLNRMTQTLKDRPTPPGTDELREFSQVRYLSDALRSQIISEQALPVLVSRINDDLTVAHPPRVSAAPSTRKNKNTIKWDRSFSDIEGARARLSASKRWPGDVKSFHRLEASVDELHTILSEEHEKVIQRQQYQHIFNHPDGVDLGIYDASRIGDLGELLTNRIKHLHESLNGLKDALTHVTGHPGDFSALALGDPHDTMEDSDIANFGIPGDLILQYNGFDRLSKKLDTLVQGFKYEPETTVFRPSIAQSYLRSLVGLRDQAHARYDDFLRDHSCGGDALEEGAERTKLLDNFNRATRQLMASDRDAARSLVIENDQASRIETKYDEKIESLVRSLHNKVKEGRDEYDRIHDEEGTSQSRVDSYRARADFCAAEGFLKEHYPTGNDSSNAKSQKQQRQLDVIAAKQFLDMAWEASRNTEEKPVEELLDEMSLAPPEQDRPTAQLSLETGQTATSGPWKSAFNWAEDEDDEEWWKEEMSKLSKVKTGQSNEDGTLGSPSTSGERSNVSAPATERANAWFGSVPASRRLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V5</accession>
    <name>A0A1E3J2V5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter, SP family, general alpha glucoside:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031170.1">
        <property type="nucleotide sequence ID" value="XM_019176695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V5"/>
    <dbReference type="GeneID" id="30193790"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="566" mass="62891" checksum="1E4D8D12BF15A8CE" modified="2017-01-18" version="1">MSDNQATASSSQFAADPIHTVRKVSEEQSFSKDQTMASMFNNAQAATAKEKSMSLREGIRLYPKAIAWSILISSCCAMEGYDISLLGNFYAFEPFNRKFGVELADGTFQVPARWQTGLSNGAQCGQVIGLLVNGLFTERYGYRKVLMCSLVWLAAVITMFFCAPNIQVLLGAEILAGIPWGVFQSIAISYASDVCPVALRGYLTCYANFCWGWGQLIGIGVIRAMFKRDDQWAYRIPYAVQWIWPPLILIGVIFAPESPWWLIRHGRIEEAKKSLLRLASPKKDPSFDVNEQADLIRHTTELEKDITSGASYLDCFKGVDLRRTEIVCAIWAMQNLAGNSFSNYSTYFFEQAGLTGTIPYDFAMGQYAINMVGVFGAWGLMALGIRRRSLILYGLAGLVVTLFVMGFLGLVPEAQKSQAAMATGSLMLVWAVFYQCTVGTVVYSLVGEISSRRLSIKTVALGRAAYNVVAIICNVLSPYMINPTAWNWGNYAGFFWGATCLLCFVYAYFRVPEPSGRTYAELDILFERKISARKFASTPVNAFEITLHHSISAKELSDHLEDKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3C0</accession>
    <name>A0A1E3J3C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyaluronan-mediated motility receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031338.1">
        <property type="nucleotide sequence ID" value="XM_019176863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3C0"/>
    <dbReference type="GeneID" id="30193967"/>
    <dbReference type="OrthoDB" id="419631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75133" checksum="527B9A7A8A86642D" modified="2017-01-18" version="1">MSANPPSRPVLVAKPIDNVNPDHNDPSQTVKYRHRLPEQKSQDLAKAKSKIERRDATIKQLQSQIQALPNPSIIDNLQKQLDDLEARHQASKGHEAKRHEWEQYAKKVKQERNSLRIQLEEKDKKMEEDARATSIANAEVQSLKDENESLKSQLSQIRSSQPAQSITSDFLNDYPAQLSSAKAELLKTSAKLSAKRQTVFERDAELRKLRIKMDGQMKSLEIDLQMVRRERDWRDKEVERLGEDKKRVEAQLAEEEGRCEQLEDLLDASARAYALHHMATVPKTSFDTLQYEHLRAKHEAADWRLKAETRGVELRMKKEEIKELEQRLEVGEEEKNVLGEAFDTMREDAAVLREEIDRLIGASISEQRSDFSIPTLDPLPSASPAIQLALSHSDLITSHFLPQITSLTSDISSLQSKLSTTTSNLTSSQSSLADLKREHASLHAAHASLERAHEPCAGIKLELEKSELECALNTKSIEGLREEVAMLKMKAKEDSEGMKRANDCVMRAKVAEQSLVEEIDYLREVYLEASKYESLYTALQEEHEILIAREQAAVQEAEDITRQNAELAGHTNEVQKISYVEGLRREMVEVKQELAGTRQMLNISYDKINALEAEIGAYKSLDSGVQGLNLGASGRMKVQRRQPEGGRLTVSRLSKSVAGSRSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4F0</accession>
    <name>A0A1E3J4F0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucosamine-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphoglucosamine acetylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucosamine transacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031389.1">
        <property type="nucleotide sequence ID" value="XM_019176461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4F0"/>
    <dbReference type="GeneID" id="30193555"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="449"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="766"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="949"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1127" mass="122305" checksum="A7CD63A3ABED7726" modified="2017-01-18" version="1">MAYAYPAHHPIAGASSTSLDIGRHSREPSRNNWGVITEFSHKVAEDDIYIRFLEERVRVEREYIDGLRKLYDRTRSIDSLHDDAPPPQKWEKPTSRIAWAEVRDYTLREIESRDAMRNALEEHVVKELVRLKDQQSKIKNSLKENIKLAESAYEEHAKHHLPKVKKSYVQKCQILEDHRRQENAIAMQARLLSTPSPTSPTTANLQEHPYAAPAGPSYTTPPSATPPLPPVSNPALISVNEIDKERVGNRLRAGSGSGLENKSRDVFNDIAASGKKGFSAFIQRLGGDKERGDDVSLAGGLEGEGLQRRGTTGSSNSKAQMAMRGAKVKRDADEADKAYRTAIFHLESLRLRREKMRISAVTHLEEFNDELSKTLKTALQLYMDIMHSTAVTNAQATEVAQRAVNVIDADHDMRIFRTKLHASMQDMSRAPVPYENFYVGPCRSLIFGVSLSDYDFARADGNDHGSPPTIVEKCLAAIDARGQDLEGIYRVNGRHAAVQKMIQGIEKDEALFEFDEKDDVFSIASILKQYLRELPEPVFNLPHAERVRYSKSRESHISSSFNALRGRLRRLPPIHQTTFQAIIEHLGRINANSATNKMGAKNLAVVFNSVIFGQDLVPTDGNVLAMHHEQDTVLEDLITYSELLFGADSPLQAPRVLPPDSGLSHSGVLTQDVGIDGPRPGTSRTKIRIAPDDGIPPEVSTRPAAERLNSGGHSSVTVTGQPDITPVAEFGPGAARGVFTRDEDLTLQFDASLIPASMKEGLPENIHVRPLASTDLLRHHFQLLNDLRPSPALAPSVYNAIFTHFHTAPGTYYVVVMVDKTTDELVASGTLIVERKHINGGGASGHLEDIVISGKMQGRKLGVRLVVGLRELAVLLGCYKVILDCQDAKIPFYEKCGFYRRSAGMAYYVSSGDVSHQGSPGALDVPAASAKRGSGDTLAPPLVSTGAITPLSDLTDTDATPRLDQYSHSNDAILGEPASRDRAASDASSEGGVLLTVPPEVAASDGSTPGTPRTFTSASSGTGTGVTYSFPTSDSSALPAWAAEGLGSKALRRTSATSSLTGSPESLGQRGGSSGGRKRMGSGLSGQGKGESEEGEELDYAARREAAGTPLPPGAAPPNLETEPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4K8</accession>
    <name>A0A1E3J4K8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031463.1">
        <property type="nucleotide sequence ID" value="XM_019176535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4K8"/>
    <dbReference type="GeneID" id="30193629"/>
    <dbReference type="OrthoDB" id="2524788at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="168" mass="17008" checksum="6A1B4F8E8A00FEAF" modified="2017-01-18" version="1">MSAQPSASAPLFFSYSPRTQLILHSSLTSAQLFAFLAPPAFLVSSLALKRTSFSIRGLMRYSASGAALGAVAGAGVGGARAGSASDLEVNAKLGQMASFGKSSLDETLVRRNDYATIGAALSALLTPAIFLKRAPLPALVLGGASVGLGLGAAGYYIEEATKGEPKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4U6</accession>
    <name>A0A1E3J4U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031537.1">
        <property type="nucleotide sequence ID" value="XM_019176609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4U6"/>
    <dbReference type="GeneID" id="30193704"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="263"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="53724" checksum="1E9D419754068F70" modified="2017-01-18" version="1">MSDDEFMMDDIADDEEYDFDYDDDDDDADDGDAGGDVENQYYKAKALKDDDSAGALKAFRTIAEDQPEKGEWGFKALKQMTKLNYLQLHQPDPALETYKELLGYTKNNVTRNYADKSINNILDYVGGEGKVRSVPIDTLEKFYDVTRVACDEAKNERLSTKCNLKLAKLWLDRKEYTRLTPILNSLKATCTPSDVSSSDDQSKGSLLLEIYAIEIQMYSDLKENKKLKAIYHAASQVKNAIPHPRILGVIKECGGKMWMNEREFGRASEDLFESFKQYDESGSAQRIQVLKYLVLNTMLNASDINPFDSQEIKPYRNDPQIMALTNLVDAFNKRDVLAAEKILKTNAATITSDPFIASFIADLLSTLRTVYIIDISKPYTRLELDYLAEQLQISRGEVENLVMGAILDGKIKGKIDQVQGVLVLDKFGAAQRARYLAVRETAVKVRQLAGKVEIDKLGPKDGGARQWTGQMAPGIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6U0</accession>
    <name>A0A1E3J6U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">L198_04109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031641.1">
        <property type="nucleotide sequence ID" value="XM_019176231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6U0"/>
    <dbReference type="GeneID" id="30193322"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="247" mass="26986" checksum="629E24C74DAC704D" modified="2017-01-18" version="1">MSIVRPLCVPKILKPRASPYRTLSSDAYSPPPRAPPSTSTSNNQSQYPPEATTTTPLLTPEQDDLLKSILRVDHAGELGANWIYRGQKWAMDVKGDTETSRQVEGMWDNERHHLKTLSLLVAQHRARPTLLYPIWQTMAFALGAGTGLMSKEAAMACTEAVETVIGEHYDDQLRELAPLLEKATATGEAPHPSIPLMTSILREFRDDELEHLDTAVEEGAQKAPGHSLLSAIIGVGCKAAINVCGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8V1</accession>
    <name>A0A1E3J8V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031900.1">
        <property type="nucleotide sequence ID" value="XM_019175987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8V1"/>
    <dbReference type="GeneID" id="30193074"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30387" checksum="30C2D8626E57607A" modified="2017-01-18" version="1">MKWNIGPPAPVPVDHPAPASSSNIPASCPMHQSTPPPPPDAPAPAACPIKHDALDPNTHMPANLSLSRQPNQQLDLPVERTASTIPRPASGSPGGEAYGTGNTWDYPSPQQFYNALVRKGWETPEDSVEVMVAIHNFLNERAWDEVMKWEKRLPGGENTQLVKFQGRPGELSPKARFHLWAGQLFPSKFNSEPPFDRHDWVVKRTVQSASNSNPSVPPETYDARYVIDYYSAPPDEDGNPVFSLDVRPALDSFEAVKQRVVVGVEEWWRGQEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J948</accession>
    <name>A0A1E3J948_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031992.1">
        <property type="nucleotide sequence ID" value="XM_019176079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J948"/>
    <dbReference type="GeneID" id="30193167"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="696" mass="74189" checksum="ABD556F13576A868" modified="2017-01-18" version="1">MTAAPPTVPSDHNGNPLPRAHAGPSRQPQREDSWAPTRYLEPPHPDNEEVLEQAAYQAAVTRAPGDDRKRKIKPRRTVDYQGGVQKWRMLNKLKGIHEFRPSIHPNASDIVNLLPPMALRSNPSTSVCDYWVHTSINKERSPTRVVQWTPDARRLLTGNDKGQFTLWNGASFNYESITQVHDDSIRSFTYSHNGQALVSADKGGTIKYFTPHLTNIHGFQGHREACHDVSWSPNDERFVSCGDDGLVKIWSYREAKEEKTLSGHGWDVRCVDWHPTKGLIASGSKDMLVKFWDPRTGKDLSTLHSAKSTINACRWSPDGHLVATGGQDNVIRLFDIRTFRELEVLKGHQKEVNTIEFHPIHHSLIVSGDAAGAINYYSLDSPTPSEPITSLSSAHEDAVFSLSWHPLGHILCSGSRDFTARFWCRARPSGGQEDDKWHLGEDGAAQRELEKVHKRAWGVPARSEKKEEASLPGLSNLMAAVGNNNSHSSSLPGLSAPPGLPGLGGLGASNGGPSRTSTPGNMSDAGFRRGALPSQGDMLKQNNVPGGRFGERGAGAPTRSVSENRDRPPFRGAPGNAPPASASGGYPSAGQGGGGYGGYPPPGAPQGGFSNHPPPSGGSGYGGPPQQGQAGYPPYGRDGRDGRDGRDRQGYGGGGAGQYGSSGGGYGGGGGRGGYSGGGGKGGYNGGGSGGYGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9H0</accession>
    <name>A0A1E3J9H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032094.1">
        <property type="nucleotide sequence ID" value="XM_019176181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9H0"/>
    <dbReference type="GeneID" id="30193272"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="480"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="987" mass="104361" checksum="33B8E23BD4298CCE" modified="2017-01-18" version="1">MSTSDLPSPPASATSPGPPPQLPVRPPLSRPLSEISVNEPRWRTSNRSSVHSSKTTIVASHKGGSRPASQVRDKEDIENEQGAIAAPKRVSSAMGLPQTITVNLADYAKTAQHAPPSPLAESSTAASHGSAIGPNAGASASASKPELPRRPQSGSSRRDSRAKAPEADGEQQAGEADDKHQSAILVAQRTSLRPTTSRPASYAEAAKSPATATPSSTLPLAHPEPRTSSLAPPTTKSKPSWLKRGGKSKSPVSNENSPGPSSKPHPPVLPPRKNKANVPDSASLADIQSVSSSDSMGAPDISDKTSYASIASGPPPLPPRNNGAGVRGRIAAWTQAAAQSGGMTRSDSTQSLAPPRLAPQPTGTSQYRMPSSASRVFGHAGSAVSKGWAGLRSKGMNSSMSIGNLSTIAQNGPSQKSSRTSPLGGGKRDRLPSDNQEISGPIFDQEIVKRPPEGNEGKVFGREIVDAGREWGVVDAGFEVDGQSEWESRRRKCLPAVVVRCVDYLEIWGPKEEGIFRISGRSSHVATLKRNFDSGADIDLADCHPGDLDPHAVAGVFKSYLRELPAPLLTKEHGPKFEELVAKKNEKVRKEESTELEDEEFADLLAQLPQSHWFLLSELVKLLDLIPKHNEVNRMTLNALMLSLGPSLNIPGAVVTELMERRDVLFAQPPPPSVLEDAADLIDFGDVDIPLSAVPQSTTSSSFSLSSLPPSPIADDVATMSGSVKRKPPRLPTRPSITKLFSGSQVNLQKQKSQETLASITDVEPPRVDVTVSPTSPLPAFDKNGEEVTPHKRDTIRAQTAPAEIPIPAIASSMTIAEMDPTEEIHYAPGTVEERSKLFSAPATPTSAASTSTPIADRYTAGHSFFPFLRAPKEQGSVRSARSSSSVGAFGEERPGSAAGSIGSGGSGPNPVSVIRRGPPVFFQSSNVESRHVRSMSSVPSGDTGRSKSPSSSRRKRKEEMAGEEDQEKRNSKRLSAGPGVLDGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBE7</accession>
    <name>A0A1E3JBE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septum-promoting GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031843.1">
        <property type="nucleotide sequence ID" value="XM_019175930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBE7"/>
    <dbReference type="GeneID" id="30193017"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="216" mass="24057" checksum="C1CB4EF3D7ED4C51" modified="2017-01-18" version="1">MADQGYMSSGSGSGRVSGGEGGDRNSVVLKVGMVGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVSMLPLVSNDAVAILFMFDLTRKATLNSVKEWYRQARGFNKTAIPVLIGTKYDQFAGFPREEQEEITKQARRFSKAMHAPLIFCSTSHSINVQKIFKIVLAKAFDLKCVIPEIDEVGEPIIIYQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC42</accession>
    <name>A0A1E3JC42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032310.1">
        <property type="nucleotide sequence ID" value="XM_019175820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC42"/>
    <dbReference type="GeneID" id="30192906"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="9">
        <location>
            <begin position="41"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30494" checksum="A1F109C670270F43" modified="2017-01-18" version="1">MSDIITPQYSPEEIERFNAELDGKTPQEILTWAIDHLDGLYQTTAFGLTGTAAVDMVSKISLSREETHLVPLIFLDTLHHFPETLELAQTMADTYLAPLHIYKPPGVSTAEEFAAKYGDKLWESDEGAYDYLVKVEPAARAYKELGVKAVITGRRRSQGADRADLKVLEVDERGLTKVNPLITWAFKQVKEYIDKEQVPYNPLLDKGYRSIGDVHSTAAPDPNAASDASERSGRWQGKAKTECGLHTNYFEMKKKFEAKAAAESATAAVELKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC54</accession>
    <name>A0A1E3JC54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032117.1">
        <property type="nucleotide sequence ID" value="XM_019175627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC54"/>
    <dbReference type="GeneID" id="30192711"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="60272" checksum="3B61537A35137053" modified="2017-01-18" version="1">MPPRPSPPSLRGTMSTLAPSAFPPSTTKPSGYFHFPGLSSESTKVAREVLEENNRDYDIYESRRFAHNHFPHSLLTRYALGAPPHLLRKTWEHDKSHLVSLDPRAPDRKDVNADKLPDKIDRGNWGAFLGNKGHYSLYLPFFHSEIARLGSQGALIEYIFSPQANWEPFTPFPYSSTGQQSKPKTPNMLNRLMAGALHPMIHVGFGLEFADPIVLAEGLAEAAIHPDSLITPFISPSLTQSWLTSPVPSPSPSSPAPSLAELYTALVNDPTLKPVPYNPESMINDQLLSAVSEGRGEALVGLVEGWEVSLKEDYEGEGGKFGWEGLMRDMGVFTTLLACGTGRKGYEPRVDFFLMHALTSSIFIPAYLPLLSPPQIRAFLKTYLLVLFQIAISRGRPPLNPNLIMSYDLYPSSDSDVGSKQDEGKEGKTIESLLDPSPPVGKGKGKNVWLDIIDRSLSYPDSHIVKSIRSLVFYSQLFGSLPAGSFSPPPSSKNGTELQGLEKVDGTLFQRAAGVIMRTIPEGEEEAGWDRSQLGYDGAWTQGPGQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEF7</accession>
    <name>A0A1E3JEF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032153.1">
        <property type="nucleotide sequence ID" value="XM_019175663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEF7"/>
    <dbReference type="GeneID" id="30192747"/>
    <dbReference type="OrthoDB" id="2572939at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="11152" checksum="55B526810DB0646E" modified="2017-01-18" version="1">MALPALDDSPTLPHPGLPCGLEHPPHLAFLPALAYPTKLAQSLEDSPSRSASPLSAEYLLSTMAVKDAFPSLVLEAIDGGSVDAGTRARAARKGKLPESTLHTRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF36</accession>
    <name>A0A1E3JF36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032570.1">
        <property type="nucleotide sequence ID" value="XM_019175467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF36"/>
    <dbReference type="GeneID" id="30192550"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="14603" checksum="5C05D088E1F06AF0" modified="2017-01-18" version="1">MSSTYNNRPLYTARPPPGLRRKLWDWSTRFEVTFALSMMHPWEKAVIWTTLALITLLFWFSLYSYLPAHVTYLQRRYAYYVYGDENVELDWFIGRVKDLVGTQMLRGAGEVQKGMGMAGGHSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF44</accession>
    <name>A0A1E3JF44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032529.1">
        <property type="nucleotide sequence ID" value="XM_019175426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF44"/>
    <dbReference type="GeneID" id="30192509"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16083" checksum="E9D82F1E4C7CDBA7" modified="2017-01-18" version="1">MVNYANITSAPGRLAYRLSTPRNRVATGIDPAFSSVLFCHPPWLDHYFFCPQLDDPIFYNEYNLVAIDMPGHGMSLLKELAGLYYEVLQALKIEKIHLVGGDMGSLAHMRLALAHPEIVESLTMVGPPTPVETDLVMMGFTDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF64</accession>
    <name>A0A1E3JF64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032597.1">
        <property type="nucleotide sequence ID" value="XM_019175494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF64"/>
    <dbReference type="GeneID" id="30192577"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="184" mass="19691" checksum="F71297BB0B0EC749" modified="2017-01-18" version="1">MSAPRPTQKNNRRKRRRRQASVSDSSSDDSSSSEDAPPIKAAKAAPIKVDGESSSSEESSSSSSSSSSSSSSDSESDSDSDSAPTSKPSAASSQLPPAKQRTRHPTNSPSPPPATGLPTFMQYSRRGKGAVNPEEEERREKFKTVYMNKLVEGFGGELEKMRESDPTLGPKRLQLLIDSLASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFC3</accession>
    <name>A0A1E3JFC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03412</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032645.1">
        <property type="nucleotide sequence ID" value="XM_019175542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFC3"/>
    <dbReference type="GeneID" id="30192625"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130313" description="DNA-directed RNA polymerase subunit" evidence="12">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="133" mass="14259" checksum="68225D6236D66388" modified="2017-01-18" version="1">MAPATVSAHRIGSLLFCPACGALLDLPQDDQTEIACSQCGRREPASSYENLPTKTYSSPNAFPSVLKSKRALVQNKLDAGEAAKGRDPVAQEKCQKCGHIGLSYKEMQLRSADEGSTIFYKCLGCGDQTSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JH17</accession>
    <name>A0A1E3JH17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032483.1">
        <property type="nucleotide sequence ID" value="XM_019175380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JH17"/>
    <dbReference type="GeneID" id="30192461"/>
    <dbReference type="OrthoDB" id="2565126at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="756" mass="79428" checksum="BFDC51CA65BB3E56" modified="2017-01-18" version="1">MHVLTGHNRRREAANLARALELSTQQAKVFANTSPHFFSSSDHATEDSREMELRPVEHAAIQSSPRASLSGRQPAESAEQKMGPPSVVANTAESLDEDISSFGVKPTSPSDIQSVTPIVNPKTSILVPESVSNNTSGSSSHKSYPPSSFPAHLLNPSPNPVNSSSFQPKADIVCDSLGLSSNGTSHTSSIRGAESSSNQPSGVSPTLLSSAAPDSSIPPPAKKIKQYGKAAKLTPSSPLKRAVGPTVPGSSLSGRKEKRRINFSSDGEDDTTADNGGKSAASVAVGPSPPKSPRKGDVPISPDPLDSIRKGKATGTPAGPVFVIEIPLSARRLNANETGEKEKGENERSEKDKVLKVPRRNLEQENLEGAEVSEEPALVLAPTGPQNKKSDTPIIVEASTSTTSLPISLSNSLSSITDSEPPTKPKPRKRKYDPLDIPDVDDGEDEDFQPGKKAKPKVKAKPKAKAAPKEKKEKKPPTGKKGKQLLGAALIVDDEGDGRVVPQPPAEEVLAPTIAAPDAPGTEGRASLRESEQPPEPPAAPPSPIRGSAAETELGRPPVPSRPSPSLGAKESLPAKQSETVKQSKTAKASTKKKGKAPAAPLPSPPPEVQPDKENTPSPAKSKSPTPPTIAKPPTGRALQKTPSNTNMRVSTPMSGASRSSSVGQESTPGPGGMKWKTSRNDLSSVLAKFGGHRRTGMSNKLNIVPLHAKIGTPAKALPPVPKKPHKKVESDEDDDDDDGEKKVKPGSKEWLMMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI76</accession>
    <name>A0A1E3JI76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032725.1">
        <property type="nucleotide sequence ID" value="XM_019174993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI76"/>
    <dbReference type="GeneID" id="30192065"/>
    <dbReference type="OrthoDB" id="10378116at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="196" mass="21893" checksum="D118BE0B69124EB2" modified="2017-01-18" version="1">MSQYTKQTWSRNDDSSFSAHPTVQKSIYLYDPIVLSEAHLEAIGATPIEDGTFTFLLSHLKYDPESRTISREVLTASKEDWEMTIDDHVKSLEATANLGDDLSLGLKPGDSESWLQLAFENGDTEALMIKEDEEFANLKLGVDVDVVEGIQLVHPSNASRMEELLAWALDLEESQGSRPEHTSQVGRPKMLKNTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIB9</accession>
    <name>A0A1E3JIB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032826.1">
        <property type="nucleotide sequence ID" value="XM_019175094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIB9"/>
    <dbReference type="GeneID" id="30192168"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="48"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="68084" checksum="C446DB9E4653E7B3" modified="2017-01-18" version="1">MSQKQLSIEECDRILTQPGSPMETEAKVIFGRRIKVWKNQPPHFRAYILYNYGRFKDRTFISAPLPRREPFPPLASDDETGVKAREYLTYGETLDRAAKLAAWMRNRGIKLGDKVVVGGKNCSGWIVSFTAIHLIGAVPVCLNAWLPREQLVYLIKLVDSKLLLLDEDRAELLSPYAHIRETGLPPMYCWSESGHLPSIVEIYNAPNSRGVREVMDGVGLEELGPESDGMIFFSSGTSGAPKAVLSTQRAALSSSLSGSMATARNFLRQGKRPPTPAEIAAMPPRVTLLSVPLFHVTGCLSWLLRAISNGSKIVTCNKWDLKEAVQLIKSEGVNTVGGVPAIASQIIQSKELPQDNTLDSVFYGGAPCPKGMAEEVNKRFPTATIIQGYGLTETNAVAVAVAGQDYFDRPESTGLPLPTTELRIADPETLEELPVGQVGVILLKGVNVMKCYYNNEQATREAIDDEGWFNSGDVGCVDEEGFLYIKDRIKDLIIRGGENIASQDVENALTSHPHVGEVAAVPLPHPILGEIVGAALTLRATASETGKDGKVKVTEEDIIKHVQGKLPRHAVPVMIMIWKEDDLPRNINGKIIKREIKEIARVEWEKRQGVQRPEVRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIS1</accession>
    <name>A0A1E3JIS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032940.1">
        <property type="nucleotide sequence ID" value="XM_019175208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIS1"/>
    <dbReference type="GeneID" id="30192288"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000308">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="63151" checksum="C6BB26A317D8E167" modified="2017-01-18" version="1">MAFTTPTKTPTKRPAFAAEAGVGKPRPTGASPAYSSRRHSLYGIEDRVVLDLGSRTWKVGFSGEPDPRAVFFARGSSIRDQSSEAWDLDLDSVNAIRGSRSEGDRLIGIRIVERLREIFAKHLLADSKQRKVIVAENTFLPTYLKEHIARTLFDNLRVPSVAFTPSSLLALGSCGRITGLVVDVGWLETSITSVYNSRPLFSLSRSTPLAGRKLHTRVRSLLHIYGSYIAPPKSLGDLSRDRSEGVPLVLLDDAFVEKVVTEGLFVGGVFVEPEDNDDAEMKDPGDIDEAKSENLEDLHLVRSLKGRYQPSSSAKDMTFSVRPPTGVTTMGYGTIMVPGWVRERAAEVLFEDDESDEAEALPHAILSSILKLPVDLRPELISTILLVGGTSSLPNFIPRLRISLLQNLLPAPSLSSDEPPPPPSPIGTLARKLEDAKLWRHRKSQPYQEIYGLFDKVAILNDPAPVDGAGNGKGGRAPRWVPSLMTWVGGSLAGSLRTGGPEMTRETYDTLLSTSLARGEVYREELEEAYASVAASVGASVEDLRVGEAVKDARGLGRRRGWRYGKGVIEDWSQTVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW7</accession>
    <name>A0A1E3JIW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033012.1">
        <property type="nucleotide sequence ID" value="XM_019175280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW7"/>
    <dbReference type="GeneID" id="30192360"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="88454" checksum="7800F21E67923083" modified="2017-01-18" version="1">MVAKNRNTATVAAASAAMISLPRAVGASPAARWGHQAVYVKSQKAMYILGGEVSASGSQITNEVLILPLNSTSPSFTTGSSEGLPPHAFAAAALSSDESSLVLVGGMTSDCSSDGLAHTLDLSGDDGWTSTTPSKLSRRRGAQSAWVDNTSVNGEIMVVGGIADSYSCANSTSVYTASDILSLPLSTSALVSSRSLPSSLTGSTLAVSDFGLASDSSGKIYLAGGQSSSGDLVSLDTIGVWDSTNGWQSQSTTGDVPDGRLGASLVAHPSLDVLVLHGGLVANTTSGSYTSSHLLALLNTTSFEWSTPSDLQPDSSSAASYHSAVMTDEGVMISAFGLSATNTPRSDVTYLDLRDTSQGAWTWESSWNSNMLNAYSTDTSTSANGATAASSTGGVTAADAKTSSGTSSKKLASIIVPVLVVALLILPIIVYLVRRRMRVMKKRRMARHFSFSSQEESGAFTSPFDQYLAKRRSQAQWPFGGQDANEQGGGIVGGVTGSLGRMVSRISNRSSEDEHNNMEEGERQMAQVGQRVRVNADGQQPMNWEEIDFGLGKLDESKNHDSSHIASSGAPVRDDRDLTVRTTTAGGYSDDVLYAAAEAKTPNSHVFGDEHAVSQPANTLSSAYPAIEPTPACTAVASDGDWNQLEQSLSSKPAFRSISPTAQLRSHAHLGSPSTPSSPTPPTTAAVQRTASLTRTVSQASTVPSIPPFEFERTESPGGTITLINPKDNSEAKEPETLPFSNKPKRLSGTPHRSVSQPISRQLAGGLSRRGSAPSSSGSEDGQSPKLSGVSGGQTAPQKMRAVSASHAAPSRKASLSSNGSVKYPSASKRRTQLRVVNMAEADEEDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ44</accession>
    <name>A0A1E3JJ44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032848.1">
        <property type="nucleotide sequence ID" value="XM_019175116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ44"/>
    <dbReference type="GeneID" id="30192192"/>
    <dbReference type="OrthoDB" id="2577415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="67774" checksum="F2CD7367635A9525" modified="2017-01-18" version="1">MWDDLGTNGMDNSFEFFEFFSAPSGDADLSAADNSETLGFVGESALYAADHSSVLGNGLGHGTFPAALDTQLPREMMMQVAEEPAQYRLPQVYTQVPIAFPQQQLYSAAPVAPANGSVATGSSFAPAVPGIQGDHQNHQDPPTNGLHVVPIGVCEDPFADITLETINAFNGPFNPIFNTHRLLTTPMAPFGVPQASILMPTESTQQAAAPMMDWTNYSYEPTADHMMAPAAIPVDPMAYISPFHVPPAAAVTLRLENSSNVSACLGDPAYQSMVPRQMPVTNHIYQTPTGAQALNPDIAQQTNHHISAAPQPAPSFVPSPHALGNYDSSLTLNSSATHPAAKNSASKRKRQSVDEGDKGSSLQVTDEDGDTTACIIKNGKKIKVQLEDGEVVQEVQRVWTGCNECRRTKRKCNRLHVDKKEPCDRCIERGIPCVYSDKERVHASKGKKKSPEEAAAFRAKKEAQKIEDARLLAEGKSPRRKTKKNVQARMVIRSSPIKFKRASKKGKEREIEADTTSASYSDFSSPPASSFDEGSHFLSGDYSSSPNSLLDLPDMPPLTEEEQEANMDDMMAAALRDSRRERERYEGEGVASSSTETPPSSDGDVFAHGSSEGYQDGEELSDYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKY0</accession>
    <name>A0A1E3JKY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">L198_03104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032969.1">
        <property type="nucleotide sequence ID" value="XM_019175237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKY0"/>
    <dbReference type="GeneID" id="30192317"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="534"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="745" mass="79347" checksum="7CEC14CBFBC95507" modified="2017-01-18" version="1">MSFVFPSWATAFSPAFHQDAKAMLEGALNKGNKPPVIQGRIEVVELHMGEQPPTLTLLEIGDLSLDRFRGILRLGYQGDAWLEVRCRVQANPLSHNPHLTSSTLPLSTPLIASQPLLVPMTLRLSKLNLRAILILVVSASKGITLVFKNDPLQNVEVSSTFDSVEVIRGYLQQEIEGQLREMFREDLPGIIHRLSQKWFSGGGVGGRVEMPYRDAPPPAYGPSDEPEDAEASEEQDIFPPPVNFGSPEKTVDSTPRRASLARAQSRRSNATTVSESPTSFTSFPDIEDYDPTYGLRPEGLPTHSGYEAFGRLWEKARQGQGRGLGSLIGMGEEDLEEGPEQDFGDPGDVSDGDWDQDDGRKSLDMVEMDHALRAIPTPSRNRSPVKARRRRQSVMSGNFSSATTENGRDGEEVEWETFPAVGGGVVSRPRVFHVQSQIRAPSEAGGAMPSPSATGTGGSVTARASSVGAASSTIGSLRMRPLNSISPGIASPGVFTPGSSNLRRMVTSRSDVFLASPTYGKSQLPRAESFAALPPSSYKATPSRPLSYGAPSHHRPRHSVATGSSSAARTSGSSWGETDGPSRSATLSTMASSQRPPSKQSASSKARPMSVPLPVPGSRLKHERVPSVSVTGTSPGNAHNGSFPPRHTGPNGITLPLNNSVSQLATLSHSAHTLSPYARGHEHIAVRSFPYHLARTRSGSGSGAWNGAGASGSGSAAGSAVGMGGLGELDVKAKRKRIFKIGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG7</accession>
    <name>A0A1E3JMG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033296.1">
        <property type="nucleotide sequence ID" value="XM_019174917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG7"/>
    <dbReference type="GeneID" id="30191988"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="8">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO02044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30637" checksum="244932501F983318" modified="2017-01-18" version="1">MPPKKEAKEKQVKGDEAEEMVLNYMRDINRPFASADVVANLKNRVPKTLAVKILATLAEKGQLTVKTYGKQLLYLYNQSLLSVLDKSELTSLDENIKAVQKDLEEVRKILKQQQSELSTKASLPKTSELGKDIERVQSEVQSANQALEPFLNTSGGKPAITPMSAEEIKKIDQDFAKWRKEWVDRRKVYKNFLDFLAENGQVSNVPVFEEELGIVDDDETAKKLEQSEMCRPAVVSKSLPRKSGPSKGKTELKRSGSDMPAGEGKKKIRKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRB7</accession>
    <name>A0A1E3JRB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033472.1">
        <property type="nucleotide sequence ID" value="XM_019174420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRB7"/>
    <dbReference type="GeneID" id="30191481"/>
    <dbReference type="OrthoDB" id="2563793at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="987" mass="108539" checksum="9A9134220AEC120E" modified="2017-01-18" version="1">MTADYHRMDRLQNAFTNLRTRTYSSADTLPQPSADEWYIPYTGNPTLPQQDPQRPQKKATHHRKTSSLGGNLRSAMCGAEMEDDGHDRRDVRYNPAAASAQRFLSRSHKGSSPSFSFPSSQESLNHNPAPVTRFPSYTSVPTGLEEPNILFSPLNRELRAKAESSGESVPLRDQPTLEESSADIRRRTVSLPNRSHHNLDTYQQKDEPRQWLVPSARELFLFPRPHLYPRPSQRAQTRVRRNSIESFSTTSSDNGARVLEKTQARAKERNDWATLVQRRGRSLSLGGRAEPPPDAPIVGNAKARERERSRSRSRERGRNGSMLNISLGGVQGRKRSASLGSRWGRHSKNSSVSDKGERGDNVNNFGKEDGSPAIPKSFDFTRSNNTFRRGGMPPRRLGVSDPNLIGSYQRNNPTPSLAHSRGYTQSHPDLYNTLHSYHEPRNPAASVPIGRTLHFKQPSVADRGGVVVISRNASSRWASSRANRSVPFLETEKPLPSLPTEQRLSSAPSDMPVSPTVDSLMFGMSPAFRGSGEFEAAQDEWQRGQQEIGVAVSPGLCHDPEAEVERSQRPEDLRFSDGSSKARDFLAKQQKLARMRKAFKAPVQSPAGYRRPGPISPHVLSPLYASTTSNGDSSRAANDSSGLLPSAPSPASSAKIQIRQPTIEERGHSRSTSVGVIEGQGKDPQALTAERPWSGSDLELKSKHGSRPSTAEHRTRSSGISTVQDEEDFHGLFFRTPHDAQSTPSLPSGNLFPPLPPLPPMSSRGSRLSFGVDTISRGNGQGLAHSTSDSQLRRTSAGSDGTMLEINTPDTMLEEILTQGLDVGPRPVTPPRRKLLAPIAIERPIGVTVRQDDSFERLPHQSQDYQSPSRPESGTMPPQNPTVLPSPVTFSLAPKQPIVSHSHHPFAHPHNFPSTQSLHTPLQSGRSRSRGDGLAVSPAMSWYRDSAAVSFVDDFPSPPGRYDVGEEEGEEMIYSPAKKRTDLSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRN3</accession>
    <name>A0A1E3JRN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_02389</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033592.1">
        <property type="nucleotide sequence ID" value="XM_019174540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191602"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="631"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO03541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1377" mass="149605" checksum="F96BDC936474C4F9" modified="2017-01-18" version="1">MSVLAALSSIPSTSYSHPIEAPPANAQKLNPYLPLPPSTSPTVLFTNATFLHSIPTSSLNRTVVHVFDAEEIVSPKGANAVSLISRSAQGAYDHALLALRLAQDEDAVVYHFIPSGLEGEIQEAEDVSAWLAGSLGTPRIAQGEEAEVSSEVRLATAFDAISLSLLKFTRRPQRPFIHNKAESSRLVVNFLPSAVEAENVVEVVLAIPAPKEKLISSLAGVKEVVVVEAGSGKYGPAWASVVDAFEESDVSIRSVLVGASASSSEITSAISGEAPITRVGKPLSYSIPSKSVAIPSPEATYTELLAASPSPLEILNDPRHLATNESTSPLYAFGKAVAIRRDRARLVQLAKKVLKGANTKPAVHEALSAWLLVRDEKKGAAEAGQKVEAAIGSAEGEEKEIVELGKKGLWEKRALWIVISNSWAADLASSGLHHALASGLDINLLVYETAASPFSPNAPAQPPKERKKDLALYALNMGDVYVASVAVYADYAGVLNAMREAETYSGPGLVLAYLPWGEKEDGQAVSATEKAGALERLRETKRAVSGGWWPMFRWNPSAADDKRFSLDSSYVKAALSEFLDRQSHLSQLTLATPAIDSSVTASAGTDLVAARKEKARKAYDALLNSLDGPGLLVLVASDGGNAEKLAKRLVGRAKMRGVGASLRVLDEVAENVVETLSQEANVLFITSTAGQGESPLNGREFTKALGKISSSEELKETKVAVFGMGDSHYWPRPEDAGYYNKPARDLFPKLMSVGCQELLPLGLGDDSDPDGVQTAYKPFEAALWRALGVDSVEVVEEKEEVVANEHIKIASDYLRGTILEGLEDKSTGAISASDAQLTKFHGTYMQDDRDIRESLKAQGLEPAYSFMIRVRMPAGVCNAQQWLDMDAIADEHGNSTFKLTTRQTFQFHGIIKSHLKKAMQAINKSLLDTIAACGDVNRNIQCTVNPALSKTHETVYNFAKDVSEHLLPSTNAYHEIWLDKKKVSGDAVQHLSADHEPLYGPYYLPRKFKIAVAVPPDNAVDVFTNDVGFIAIVENGEVVGYNVSAGGGMGVTHGNKKTYPRLGTVLGFITPEEGKKVSESIMLVQRDNGNRQDRKNARLKYTVDRLGFPKFKSLVEERWGQKFAPARDYHFDSNLDHYGWQQGHDGKWHFTMFIENGRVEDNAKHQFKSGLKDIAKVHKGTFRLTANQHLILSDIAPEDLDEMKRLLNKWGLDHIDHSGVRLSSSACVAFPTCGLAMAESERYLPVLIDKVEKICEEAGIRNDALVMRMTGCPNGCARPWAAEIAFVGKAPGAYMVMLGGSHLGTRLNKPFLESATEPEILAVLKPMIKRWALERHEGERFGDWTIRAGYIKPTTEGMNFWDDSFPSQQVQAPAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTU0</accession>
    <name>A0A1E3JTU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquinol-cytochrome c reductase subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033588.1">
        <property type="nucleotide sequence ID" value="XM_019174536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTU0"/>
    <dbReference type="GeneID" id="30191598"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="74" mass="8168" checksum="23CD963748197F5A" modified="2017-01-18" version="1">MPAFARRSQIAFAGLSAERLSKWGPSLVFWGVGAGSFVSLLLSEVPLFQKDILRKVPVVGQYWVDTVPDSDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW77</accession>
    <name>A0A1E3JW77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01798</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033766.1">
        <property type="nucleotide sequence ID" value="XM_019173959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW77"/>
    <dbReference type="GeneID" id="30191011"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000040">
        <property type="entry name" value="Methionyl-tRNA synthetase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="466"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="605"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="721" mass="80692" checksum="FCB406D2A04182D5" modified="2017-01-18" version="1">MSTDHIRKADGLFMEVRDPKDGPVLPKDGQRNVLITSALPYVNNVPHLGNIIGSTLSADVFARYNRTLNVPTLYICGTDEYGTATETKALEEGVTPYELCTKFHKLHTEIYDWFQLSFDKWGRTSTPEHTDITQGIYKRLHEKDLFRLETADQTYCEDDKLFLADRFVEGICPACEYDDARGDQCDKCGITFSSPTQLLSPRCKRNKNHKLSVRPSTHACIRLDLIQPKLVEWMQQARVKGRWGTNAVITDKGEIVEPRMLGEGLRPSAVTRDLKWGVEVPKIGNKEEDEALEGKVIYVWFDAPVGYPSITATLTDQWEKWWKNPDNVELYQFMGKDNVYFHTVLFPSMLLGTEEPWTMLHNISSTQYLNYEDTKFSKSRNVGVFGNNARETGQPPEVWRYYLISQRPENSDSAFLWSKFITANNNELLANLGNFVNRVIKFVNAKYDSKVPGPADLAGGVPTPTTQIDKDFVADINARLTKYRQLMDDTKLRDGLSQAMSISARGNQYLQENSLDNSLLANQPERCAEVLLNAVNLIYILSAVFHPFMPNTCDGILRQVNAPARSLASEFSVDILPGHVLGKAEYLFKKIENVDGAQEKKWQRQFGGDAVAAAETTPSGPGGHPEGGKVPAANDASSKKAAHEARKAQIAADKKAAQAAADAKKTPEERELEKKVEVQGQVVASIKKGLAQGDEEEEVKKAKALKAELAELKKKLKEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW82</accession>
    <name>A0A1E3JW82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033760.1">
        <property type="nucleotide sequence ID" value="XM_019173953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW82"/>
    <dbReference type="GeneID" id="30191005"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="17483" checksum="B41011EA93F6B03C" modified="2017-01-18" version="1">MPSVVKMVLGNGPLGPSFAPWIRQHSGIQKYWSRWSNLYKQAAGYRQKGYLLDDLVPEETALMQKAISRLPEKAGFDRVFRQRQGLIQSALHKELPKEKWTTAQQDERYLTPYIEQVLAEDAERAEWDHHVVEKIQKRRASKKSPFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ97</accession>
    <name>A0A1E3JZ97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034308.1">
        <property type="nucleotide sequence ID" value="XM_019173603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ97"/>
    <dbReference type="GeneID" id="30190653"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12286" checksum="D74405AF747AB461" modified="2017-01-18" version="1">MFGIRAYQDSAIWKKPNWEPLYFALGFTCLFFLIRSVFRTVELSDGYIGYLATHEGYLFGLDTLPLLLGVAICTVGSGQGGISRLTETLSSAGTLVLKGQQMRRGLRMSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZA2</accession>
    <name>A0A1E3JZA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033887.1">
        <property type="nucleotide sequence ID" value="XM_019174080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZA2"/>
    <dbReference type="GeneID" id="30191135"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="731" mass="75891" checksum="A4C78C0955509DEE" modified="2017-01-18" version="1">MAVESVAVHSDATGTPQSQAPIKNNASADVDTLQGQVNEMSLGNTEFDLHAACAEGNLDQVKATLSKGTDKLETLDVNTGCTPIVLAIRGNQYDVVRELLAAGAIVPPPGLTTDSTMLSILYPQPVYNMPPQFMTIPPQEYYPQPNYFPQQNGGENQQQFGSPRKESVSAPNGSNSNLPPADVSKSIPCRNFPNCKYGDACVFLHPRAAGFYPPGPGPQSGYPAPQNYEGFPPYPPAPAPYFMPHGGNGFQSFQEQQVAGQVEGGAAPGPTGPHVPSAVAPVFVPGFQPGDMMASPPPSHFGLSPMSPSMLGTSLPSIPPAEVFFAASPPNNGGFLPPPPMANGAPRRQSVGQQFGAPNGKPFGHGKKPSFSGGKPWAGGRPANATSKFGTWKDGVPPPCAFFNQGNCRNGELCKFPHLDAEGHDCRHPDVVRGVLPPLPPLGNGKRNMRSTGPNGGFAPFDPSFRQQQQYQQQMQFLQHQRMAAAQAQQGQAAATSAEGKADEAVAEEGNTVEGAEKQAVAPAATPAENTLPSKPLAAPMPTIIRSASQPGVQRVHANGLSSRSHSPAPSNVSFHGNGHPRRAGPVPNANGVASGRSASSGPEKKVSQRIPGADEFPVLGTPTSEKKEPVWGVAGKTAAQVLQAPAPVKPVTAKSEEDNQPGQSVTMESEDDSDAVLVSRKPSSATTPASSTSPGPPVLETASKKAAPISFASVASSAAPAETAAVTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZQ1</accession>
    <name>A0A1E3JZQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034365.1">
        <property type="nucleotide sequence ID" value="XM_019173660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZQ1"/>
    <dbReference type="GeneID" id="30190710"/>
    <dbReference type="OrthoDB" id="2536714at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="713" mass="77199" checksum="0A400CB4B4D70B0F" modified="2017-01-18" version="1">MAPTPQTPTAIHTYPASLSKASHGPSRPPRTYPTPSIDSDIASPPDALAPLHEYSSLQELLQKAGYKDTRVYTPEAEKIRRNIKKTLDENEEEVDALYGTYGFDRGVQHAHQNVTEPMMPMKRSTSILRSLAVQAAARSAASVGSNGPDQSWWAAWGKNPRMSPPEPSTEVGLSLARNGDGVRKIKSTWELESGRTRRAETDSPLQEERPPLPNCRQVSSPQEMTSAIGYTPTKFTTNPLDKSIFSSPPPPPALPDDAFGYCPLPDDYEAQCAEDEALYAMGANDYDAYSLGSGSATPSIRSSFSGHSRTPSDDRAEREIRQFQDEMDGELNEVNDVGQRLLAGAVEYDGESEDEEEQEPIRTWSLPKVMVETPSSGEAPTIPMPSPPKPVEAPRETPVEEVKKPLKYGDRAAKIRLAHSTPNLKKAETAPPALPSGWLGSIRSALLGPTPSTSSQIKARPPPSLRVSTAAPAQPRLVTASPVLCDSVSTDAEDLPPVPSPTEGSSLLRYRPSLAKLRQTFLGNASAVDGDALVLSPRLDWKQQGEEFAGWSPMRKTGKAEAEVAESTEDGEIDWSKSFFYKPSTPPKARAGEPETPKAKQSSSVSTGTVRGPRKQRSIKSLQAALLLPVAPTPAPPVPAIPSHLLSTPRRIPQLAIQSPQATSPRELVLDGDEFYPQSLPDSSKRGRGSSKRGNGVRRRKSKKKSGLREGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZV1</accession>
    <name>A0A1E3JZV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034426.1">
        <property type="nucleotide sequence ID" value="XM_019173721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZV1"/>
    <dbReference type="GeneID" id="30190771"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21880" checksum="CDF57334A50AFFB4" modified="2017-01-18" version="1">MTTHHPRTLPVILITGTPGTGKTLHSQLVVNELTEDGTPMKHLNIGDIVKEHGFHEGWDEEWNCWVVDEERLLDWMEEVVNPRDGPAQTGFVIDHHDPSLFPERWVDLAVVLTCDNSILHDRLTSRNYPEKKITENVTAEIMMTCINETRESYAEEIVVELKSEGQSDGEVDENVGRIAQWAVNWKKDQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZW3</accession>
    <name>A0A1E3JZW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034480.1">
        <property type="nucleotide sequence ID" value="XM_019173775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZW3"/>
    <dbReference type="GeneID" id="30190825"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15566" checksum="13CF473DDFEE1186" modified="2017-01-18" version="1">MCSALSPRCTNINKKHKKRVRKIRLPEIISLSPAQSSCIPLNNLWAADNIAGHYKRAVSCGTIQLTGNISGAIIGFIFTSQSAPRYRKGIYFDIAATVMSMCCTIVLLLGTRAKISKKAKQVAAGAPDDNSLGDENPHYKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0B8</accession>
    <name>A0A1E3K0B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034563.1">
        <property type="nucleotide sequence ID" value="XM_019173858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0B8"/>
    <dbReference type="GeneID" id="30190908"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="879" mass="93926" checksum="62F1DD647ED63702" modified="2017-01-18" version="1">MALPPTSHENTPNAWFLQLRSTNANTTTPREFSIAKLACTDTKDIPTKDGKPTKPAGLVHGGVILGRKSSQTKEHGESGVFISPILSRAHAQLTVSTNGHVYITDLSSLHGTSILSAGSSELVSLDPYSPVQLCQNDTIVLGKDVYADGKEFTPFKLQVVFAQPVFGKGSDKGTRKSIGKLTPEDCTGKFLALSQIPLFEKNVSKIDDAPVVIDSDDEDDIEMLEGDKSSKYGIPAWMRYASEAPISQARYENAANLSDEDGDDIVAIPNKEDIGLQRVAKSQSILYSDDEGDDDDYPRGTAHVSLEGDVVASEDEDDNEQDSPEVQGVREVIRSFTCRQSSPEYSPSIVPAAGPEKNLNAQSLSLSKESPLSLSSILNQAEGRGKRDGSLQGKSLFDDYQSSPAPFANCHALEGIDSGDVFDYEFQATAQRAAVEQDKYAEDTEVNQSAKVSASDLAAFLASEILPAKSVPAFSVEDSESESGDVVEPAQAPVAPQHEPKGQNAFDDAMSAGWPSEQDQAPVQSNADFAATGGDEVLSEGEEESGVTTGDEEQPLSAVLDDQDEGLVSDAPSDTSYESEDSAVDDKESSASESEGESESGSESESEGESEIDASKHEAVKKQRDLLRAITGKDIKKLNSKQSKLQWFGTSLPDIYRGPEECLDDQQLAEYMRGAAERGADAGSDPEVASQAESEDEDEDEGEGEGEDESVQQESEFEARNDDKDVQSETEEESDDEDAPCPTQYVEAIDVDAPDTLQPAADLAAISDPIATPSTSSPASDRILTPIIGQKRSLPQDDEEDEDLVPVLQLKRLASVQVPTETPGESSVIEVNTAIAQDNKVVQPPAKRRNVAQAMGLVVLGAALGSIGTIAGLMQLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0D1</accession>
    <name>A0A1E3K0D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stomatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034581.1">
        <property type="nucleotide sequence ID" value="XM_019173876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0D1"/>
    <dbReference type="GeneID" id="30190926"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="118"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="40342" checksum="3409A4465522F923" modified="2017-01-18" version="1">MSHDNKVSMDATTIDFNNSTGAKTQLSSAGHSVPGSEELDRYVTDDVPRQQKMSVRPQTAPEGGLIAVQPLQKNEMQPSYAQDLGAGSIDHGCYGSFMNGLGACIGALGVVPCCPCPNPFHNISQGSVGLVSRFGKFYKAVDPGLVKINVCTEGVQVVDVKIQLTGVPRQTVQTKDNVSVDVDSVICWHVISPYRAAYGISDVRSALVERAQTTLRQVVGGRVLQSVISDREGLAHEVAEIIEATAEKWGVAIESILLKDINFSIELQQSLSSAATQKRVGESKVIAARAEVDAAKLMRQAADILASPAAMQIRQLEALQNMARNSGSKVIFVPMNLGGMGAAGLNNDVADQIRASGHEGENAEAGPSSASNAGLITSMANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0F2</accession>
    <name>A0A1E3K0F2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TKL/LISK/LISK-DD1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034593.1">
        <property type="nucleotide sequence ID" value="XM_019173888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0F2"/>
    <dbReference type="GeneID" id="30190938"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="601" mass="66021" checksum="009A6BC56AEAC162" modified="2017-01-18" version="1">MDFDIVPYEDIVWGRKLGSGSFGSVYQGSYLGIDIAVKEILPSNEYDVHKYFEREWRIMRECRHPNIVLFLGLCQAPEHNGRVFIVSEFVPCGNLRQYILSSNPFPWRLRLSFATDVARAIAYLHARQCIHRDLKGENLLITSNQRIKVTDFGFARIASRNEEELKRMTYCGTDGYMSPEIINGGDLNLPTDVFSLGIIFIEIMSRHVVDSKHFTRQAPSFVPDPTEVTARASPGCPRAFIDLALACTAEDPADRPKMTEVLSRLRSIELQVLQWMDEPGEHVGSIKLHRREGKRAMPVFDAPQAPETVADPEEDEEKRAEEEALKRLAEMRVDVESGQAAVGERDTAGDVEERWRTARWKEPRSFATYVTAASAFTGHQPLIESTPSSINPFINPSIQNSHSSFNSDAARSPTQTASVLQPATPFAEETVSTMTIKNGGTAAATVTPTSPTSPGAPVGATQDHPYSTLVTHCGGSDPDEEAQEMHSPPIAIPTPQSPRSPSRTRKIVNNNAATHRFTLVDRDPISLVGRKPLASTLTSTFTALLPRKPPSSPGGKAAPASSKKPTQGFGGISSSKCAVCSKRIGQRPAMQCDDCHGKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1K5</accession>
    <name>A0A1E3K1K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034427.1">
        <property type="nucleotide sequence ID" value="XM_019173722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1K5"/>
    <dbReference type="GeneID" id="30190772"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="121" mass="13499" checksum="4099ADD8167781A5" modified="2017-01-18" version="1">MSDPTSIAQQFTQFYYQQFDSDRNGLASLYRDNSMMTWESTQIQGSAAIVEKLVGLPFAKVQHKVVTIDAQPSSLSVASLIVLVTGQLLVDDGQNALQFTQVFHLQPEGGSYYVFNDVFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1U3</accession>
    <name>A0A1E3K1U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01639</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034507.1">
        <property type="nucleotide sequence ID" value="XM_019173802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1U3"/>
    <dbReference type="GeneID" id="30190852"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="195"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO06407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="395" mass="42559" checksum="3008527341A886DA" modified="2017-01-18" version="1">MVYEATSSAPVNIACIKYWGKRDTKLILPTNSSLSITLDQDHLRSTTTSRCDSSFEAGDRLWLNGKEEEIKEGGRLSVCIRELRAWRQEVEDKDANLPKLSSFPLRIASYNNFPTAAGLASSASGLAALVASLASLYSLPQSPSQLSIVARQGSGSACRSLFGGFVAWREGTDPAGSDSLAEEVAPREHWPDVHALICVVSDAKKGTSSTSGMQKTVETSTLLQERLKIVPGRMDAISKAIKDKDFESFAKITMADSNSFHAVCLDTAPPIFYLNDVSRAIIAVVEELNRAAGRILAAYTFDAGPNAVIYTLEKDMPVVLGAINKFFPTAEEFEDPFKTGVKALPEGYNAGVVREGGWEKGAVKGLIHTRIGDGPRKLSAEESLLNEAGVPKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C0</accession>
    <name>A0A1E3K2C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Solute carrier family 25 (Mitochondrial aspartate/glutamate transporter), member 12/13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034623.1">
        <property type="nucleotide sequence ID" value="XM_019172897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2C0"/>
    <dbReference type="GeneID" id="30189938"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000147">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial aspartate/glutamate transporter), member 12/13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="336"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="436"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="536"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO07146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="686" mass="75066" checksum="B82C4ED2F3365FD1" modified="2017-01-18" version="1">MADNEPLPARLTSSIRHTVQPPENELARWRRTFDRFAAAQAEGKKYLNPVQFVDAIAPTDEGFSKIKKEQYANLFRVADSSRRGLVSFEDFVVFETLLKRPDADYQLAFQVFDVDASGSIDFDEFKAVLSANTAASGIPFDYDCSWMKLYVGTRGDRHVLGYHEFTQLIKGYQGERLRQAFHFFDKDGDGYISPEEFQGIIVEIAGHKLSDSVLARLPTLCTMNPGKKISYSEVIAFHNEMDTVELIIEHAVQKSKDGRIDVSDFLNEAAGRMRYGMFTPMEANIIWHFASRGSVGSGQRLTLADFQALLDAKWQPPEATASETALKSNGFLGEAAQSIYNFVQGGIAGGLGAYAVYPIDLVKTRLQNQRSTVVGEVLYRNAFDCVKKVYANEGGVRAFYRGVLPQLVGVAPEKAIKLTVNELVRKKATDPETGRIPLIMEIVAGGTAGGCQVVCAFPVVVPILSCPQAGEITRAEGGGAVPRGAFHIIKQLGLIGLYKGATACLARDIPFSMIYFTSYAHLKKDVFGEGRHGKVLSFGELLAAAGIAGMPAAYMTTPADVVKTRLQSQSRAGQTVYKGIADGLVKIFQEEGLRALFKGGLARVIRSSPQFAVTLACYELLHKHFPYPYAPAPAIARPSRSAQQDISRIRARNALRILLDCSSQFGMVDANTAAKGVSILPKSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2G0</accession>
    <name>A0A1E3K2G0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034712.1">
        <property type="nucleotide sequence ID" value="XM_019172986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2G0"/>
    <dbReference type="GeneID" id="30190027"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="57972" checksum="A1C986F1D2503A6A" modified="2017-01-18" version="1">MPPRIPTRAFTALPISQPVASSSAIPPQPRCTSPRSSPSHHFSTLHAAARPLSGNATEKRRSFHSTAVHSASAKDPYDVLGVKKESSSSDIKKAYYSLAKKWHPDSSKEPNAKDRFHEIQSAYDVLSDDKKRKAYDTYGSASQQEGFDPNFPGGAGGFGGFQGFGGGFGGGGNASDLFESLFGGQFGGGRGGFGGGARQRPVRGDDLEAGVNLEFLEACKGTTRKVTITPVVDCKPCTGSGLKPGEKKTQCSTCRGTGQQTFQVQGMIMASTCQACGGAGSSIPPSAKCGGCEGVGKVKDRKVVDVEIPAGVEDGMMIRIPGAGDMPLAASGPPGDLLVRVLVRPSTKFRRQGTNVHHDAKVPLHTALLGGVIRIPTLEGEVDVKVKGGTQNGEEAVLKGRGVQSVYSRGKSERGDLIVQWKIQIPRTLTPFQRKILQAYADDLEGRTPQIHFGPSPSESASTPNGETSSRNTSRPRPSWSTHPDAPRRTVYEKPHFPSHPSSPSSSSQQESSRPYEPVDSDDSGLAGKVASAVGGVIGWVERLLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2W9</accession>
    <name>A0A1E3K2W9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_00945</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034843.1">
        <property type="nucleotide sequence ID" value="XM_019173117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2W9"/>
    <dbReference type="GeneID" id="30190158"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="16">
        <location>
            <begin position="450"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="730" mass="78417" checksum="493C4FE28B488222" modified="2017-01-18" version="1">MPADTINIASLAVHLPNGLGPSAFHLTPPPPCPVSISLTIHLFPGSVKATSEGDDMTGLGVNYSAVSKAVYALAGGQEKVWGDAWELMRAVSEIPLDLPDVQSVDVRIGLPKALLHAMEAVYTAMYTKTGGLVEESRSSEIRDLKVVCIVGLHPHERKEKQRLEVDVRAYDCDWNAWGHKGFADQVYEFVSNSEYGTIESLDHELGHSLLSSKYLGSGNTPRLQITIRKPSAIPFATPGITIHRTHSDYSPTPSTSQECTGSERVFIAVGGNIGDTVSNIKTAVGLLQSGGCNLIATSRLYESEPMYVEDQDRFVNGVIEVTTSLEPLDLLRLLKRTERATGRTKTFTNGPRVVDLDLVFYGQRVLKIGSETDAEDADGVRWLECPHARLGEREFVLRPLADIDASFTHPAVGKSISQLLDSLPDPSSLGPMIPLRTHSRSLRLSSPATPRIMAIFNATPDSFSDGDPSRTSTKHALEECLKLIEQGGADILDIGGMSTRPGSEPCTETEEVERVVPLIAAIRQHSNTKLARIPISVDTYRASVAEQAVAAGASIINDVRGGREPGMLAVMSAADVPVVLMHSRGDSKTMTSAESQDYTALGGVVEGVKKEMAETVELALKAGVKRWNIIVDPGLGFAKSGSQSLTLLRRLLELVSSSSPLHNYPLLVGASRKGFVGQVTGRTVAKERSYGDAGVSAWCVGSGGVDILRVHASGEMGDVVKMVQAIRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K374</accession>
    <name>A0A1E3K374_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034958.1">
        <property type="nucleotide sequence ID" value="XM_019173232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K374"/>
    <dbReference type="GeneID" id="30190273"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="35938" checksum="E311CE6AC26D3B83" modified="2017-01-18" version="1">MVKTVPFQDIQVPVPGFGAMGLSMAYGPADDTESHKTLQKAIDLGCTFWDSAVLYGAGHNESLIGDFFKKTGTRDKVFIASKCGYDDPMTTICNVTNKPEHIRAYIEGTKDRLGSYPDLYYLHRIDPNTPIEESVTTLDELRKAGKTKYIGLSECGVETLRKACSVAKIDALQIEYSPWETTYEENGLIAAAKELGVAVVAYSPLGRGILSGSQSLDDLDETDFRRMLPRWSPENFPNNIRIVDEFRALAEKKGTTPSQLALAWLIAQGAIPIPGTKIRTRLEENFKGGDVDLSEEELKELRALIEKAKPVGERYMDGALQQLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K487</accession>
    <name>A0A1E3K487_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034834.1">
        <property type="nucleotide sequence ID" value="XM_019173108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K487"/>
    <dbReference type="GeneID" id="30190149"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="17874" checksum="D6D85E84B7ECE045" modified="2017-01-18" version="1">MNALSKSKGKPHELHPKYTPSISFQSVPAESATLQQAQQAGEGFKSKLFGSFPRGEVTVRKNDSILLDILGKLGLNPNVLFSPADWASFQYYDTKFCGPKLTLSDHANPIALHTHLGLMRYFDNTMLHPLNMSIGDKEALWSSAMKSCHGLLGRSRGEDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K547</accession>
    <name>A0A1E3K547_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035181.1">
        <property type="nucleotide sequence ID" value="XM_019172239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K547"/>
    <dbReference type="GeneID" id="30189263"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="12871" checksum="FC96BE398966265B" modified="2017-01-18" version="1">MPSMVTAAFALLSVIACVTLEGYGYWWMLSIPSAIGCIPMMIFWVYKTVKPVNDYFHTLNDALGTLYKGMSVQYATDVGRVGMAFSGVCTGVCVSVVIVVSWIQMKERSSRDCFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T3</accession>
    <name>A0A1E3K5T3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035153.1">
        <property type="nucleotide sequence ID" value="XM_019172211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T3"/>
    <dbReference type="GeneID" id="30189234"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="415" mass="47184" checksum="060A491A1E306633" modified="2017-01-18" version="1">MSSSAEVAHTVDILLVIFSYLTPRKHLVPLLRTSPLFFRLVAPKLYNPLPISNACNPLAGVSLSGEDQGPYSKARLLNSAPAVVVERAKGPNGRSVWTNFDRHPSLPSVEIVIMQSLLWEEQTSGIDKAEPTRLSNSIIEHLCSAATRLELLTPAYTLVGASVSRERMPSLPNVETLVVKGTAAKLQGMVHVVGDYGDHDKLPCPNIKTVHLFLWGDVMQYPLRDQSRTSFWDMDKGKITLQIREMEHRLYKRSYLLGHLPDMLKALGSRVSSVDGLDFWLYNVDPIFQRSGYLKGTRLVNRFKYMLERDFEWKMLSSTYPDPPDEDRKIRVFFRTGVDFYKYKAFNSIPISAEEEWYYSAVLDPSARLVSLRASLEAETGLHGRAFMGLGEHEAEWLLRAYTRPTFAELYLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K604</accession>
    <name>A0A1E3K604_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035223.1">
        <property type="nucleotide sequence ID" value="XM_019172281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K604"/>
    <dbReference type="GeneID" id="30189306"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="706" mass="77804" checksum="9BC5A9FB498B4443" modified="2017-01-18" version="1">MPVPIDSLPLPTTILPLQHALPRLPLPKTPSAQRRSTIFKSSTDGIWAPVTPLWAPWPIRLSPEEAIAMGYDPANPEGLGVDEILGRWDPVDSSPVESKANGLIMKSSRRRLEMEPIILAVSPRALQEVLPALDPGDILSITRSGTFPDSPNAARDSFIDILSTRKVLSSDTYGPWSTRYAGHQFGAWAGQLGDGRAVSVLETESEQGGRQEIQLKGAGRTPFSRTDDGLAALKGGLKEFLGSEATAALGIPTTRALALHTHPLSTLPVFRSSSLSPASILARVSPSFIRIGHFEALSPPEGGRGGRQVFLGLGTGSGGGREEWVDNQAEKEDEAEEGDPKERVIGNLEGLRDLALYMKALMGSSDSGLESWKGWIFKIIELNAKMVAKWQVYGYMNGVINTDNVTLLGLTIDYGPFAYMEVFDEGHICNEDDTSGLYAYRHQPSRILFALQKFATSIAPLVGYLHLNHGALPQGYTKGSSKEDVKEWATKGEEVMKGWNWEEEYWSVQKGQELDGWRARLGLKTVQESDQKSIRSLLSLLHDHRLDFHSSFRALAYFDPIKASSDSEEGDYLPKFARRLVQEAGRGKGSHEDKTEELEKWLAEYVTRAGTAEERAAWSSSSSDFLPTRLASLLSLNPSFVLRPSILSSLGEKVEVLLTAPYKDATSKDDLDNEKVERGIVEARREIWNVLERAFDPFKDCNDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J5</accession>
    <name>A0A1E3K6J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035412.1">
        <property type="nucleotide sequence ID" value="XM_019172470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J5"/>
    <dbReference type="GeneID" id="30189500"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="206" mass="22877" checksum="E5F24D7795F8C863" modified="2017-01-18" version="1">MGAKPISRKLVVLGDGACGKTSLLTVFTKGYFPTTYEPTVFENYVEMMEVDDQVVELSLWDTAGQEEFDRLRSLSYADTHCVMLCFSVDSPVSLENTESKWIHEINEFCPGVKIILIALKCDLRDDQGVRDKLARRNLHTVTYDEGLATARTIRASRYLECSAKHNRGVREAVYEAGRVAVGSRAKGGGSGGRLKGEGWKDKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6L9</accession>
    <name>A0A1E3K6L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonuclease P protein subunit POP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035689.1">
        <property type="nucleotide sequence ID" value="XM_019172747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6L9"/>
    <dbReference type="GeneID" id="30189780"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="39389" checksum="9CCE5FD56C75DE12" modified="2017-01-18" version="1">MSSKHASGSATPSRDQSPAAPAPGGQQIDPYRVLSTHVKKPLAPLLPGSEPLLPTLLSLDSTAYSSRLSGKTLQTTPDQPSTVSSPLVTGRKRNRGNALEKSKARAECQATRKKRETLGHEGLRKVKRRLGSVIGKGQCISYTALVPLYHLHTTYICQLLALPTLPALIPPFLPPSNPEPLQTKISKADFTGIFLSVIAARCESLIGIKGIVIEETAEMFKIVVEDDKVRVVPKQGSLFRLSFPAFSPPPQKPLAAGIVPSPYPQDLTHHLATCPRIEMDLLGSAFAYRSIDRAGRKFRPAQGGGGGSGWADGWVAKAGEMGQMLNGVDGCERLNKTEKSEAKQGPSKRKRNKSRRKDLPAWGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Q0</accession>
    <name>A0A1E3K6Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035399.1">
        <property type="nucleotide sequence ID" value="XM_019172457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Q0"/>
    <dbReference type="GeneID" id="30189487"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="56" mass="6288" checksum="6B4B8C607381A966" modified="2017-01-18" version="1">MAPKAKARRILVKLVSTALTGSFYTTSRVRVGDKLAKIKYDPIVKKHVLFTEAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8H9</accession>
    <name>A0A1E3K8H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035682.1">
        <property type="nucleotide sequence ID" value="XM_019172740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8H9"/>
    <dbReference type="GeneID" id="30189773"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="542" mass="58996" checksum="2C144CC7DB6BDEBD" modified="2017-01-18" version="1">MEASMAPSARMVTPPYHHSIVSTAPTNLLYRGAIPALRNLHFIATLQLKTFVVLSKKSLEDDHPLLRWAKQTGVTIYWEAAEQMSEEKLGMGRPQVDQWILDTTTYPLYIADVDGKSHTTLVVACLRKLQGWHQDTILDEICRYQEDQEDLPLLPFVTAYLAPTSQETLTLPPPPYPSWIWPSASSEVDFKPSVSRPSQAFPSPNPPYPQPQTKDRPSSSLSAASSTSSNILPFPHPLQARKHPTMRLTFPTPPASSSNPTPNQSAAGQKDMQVASPVAVIGDGLARIPSRRERERDKERVTKGGERVLSPHPPGKDQTAPVLHVPTPTRSTTNSPSRRSHHHHHHHHHHHDVGQVQTAARSRPDSAPGNESRLRQGIGSPDEGVLGAAAHLMTAGLSGIAHALGATPPHAEDDQDGQNGKTVEEGGGYDDEAEEGDLTVRQSPIEALKAVSPSLSTTRDSEDLRSVSSATGTSTEFGMDTGASTAGTETGLETDEEEQVSEEEDEDGEDEDDEDEEDEEDEDEDDNQATSQFISALDLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HB93</accession>
    <name>A0A1E3HB93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000066">
        <property type="protein sequence ID" value="ODN73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027766.1">
        <property type="nucleotide sequence ID" value="XM_019180252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HB93"/>
    <dbReference type="GeneID" id="30197497"/>
    <dbReference type="OrthoDB" id="10302134at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="41132" checksum="EFA2B01157153E79" modified="2017-01-18" version="1">MAPRKPQPPALPAFSITTLAPLAPVHYDIIDHLLHLAPTTYMRLSKAHHHHALKIFSQPVLIDHSFEDRFYKTTTADQAQSLAFLLPAFYAEAVRVDDVRIWAGLAVDFGRVYSQRKRRKAGSGFACEYHPDRLFRHVRQIGVSLSPFATIPSLTEKAAREKNYQLKNLFDQSVDHEIGKHFEELAIFVDKPFRGDTDSKQYAFDHFLPTGHWARQKMTVIYIPFFAKGGPTIDDLRVLLPIVLAQNLEYHSSKIIIYPSSSSSSSGASQSCIPSDVATIIARYLAGRARLRAARHNAGNRTVFDIKYAEFHVPDAESVRGLVMPLLSDEVRGRFGSYRAEMERDMRIVELDPALVVTSGYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH00</accession>
    <name>A0A1E3HH00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_08147</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027887.1">
        <property type="nucleotide sequence ID" value="XM_019180118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH00"/>
    <dbReference type="GeneID" id="30197358"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000595">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="18">
        <location>
            <begin position="370"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="593" mass="64863" checksum="BDC5C812E15F2F01" modified="2017-01-18" version="1">MSVSDSDSSHEALRSELSSIITGVESPVASPSTTPTTAPEDDYTPFPSPVLSATRLAGLSLGEDGELEDEVDADKVITEEDKTKALELKAQANKAFAAKEFNKSIDLYSRAIALNPKDSTFWNNRAMSKAKMEEHGAAISDATKAVSINPSYAKAYYRRGLSYLAILRPTDSVPDLKKALSIEPNNRVIREQLNTVVKLIRRIEFEKAISVGDTETASQRCLALIESGACTLDPASAASDMPLPTIPSDPLARYTPTKEFVEGMIASFKKGGKIPKRVAWEIILGCKEQVEKEKSLVEIDIPEGVTCDIIGDTHGQFFDVCNLLSMTSPPSENHYLVFNGDLVDRGSWSVEVALTAFAYKWLYPNYVFINRGNHETNDMNKVYGFEGECKAKLGEMTFKLFADVFTMLPLAVLLSASLPPTSPKSEGSGPKPAILNQGKRRFFICHGGPPVSKDGVTLEEVSKLERFGRQPGQEGVICEMLWTDPQEPIGRGPSKRGVGLGFGPDVTRRWCELNNVTAVIRSHEVRADGYAIEHDGLCITVFSCPNYCDSTGNKAAYIRMQANGALSYHQFDAVPHPDVKPMAYSSGFNQMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HIZ9</accession>
    <name>A0A1E3HIZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027938.1">
        <property type="nucleotide sequence ID" value="XM_019180084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HIZ9"/>
    <dbReference type="GeneID" id="30197324"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="90" mass="10087" checksum="76642690749112A1" modified="2017-01-18" version="1">MVLKSFRLTSTTTRASLEVMDPCDSEPRPDILFCASMWTPEEQTEIQRIAKNTIPCIKTYAIPTGMHVKAGPEGIIKYLTERIDSIVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP94</accession>
    <name>A0A1E3HP94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028064.1">
        <property type="nucleotide sequence ID" value="XM_019179942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP94"/>
    <dbReference type="GeneID" id="30197180"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="424"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN78180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="60004" checksum="B3DD108162160CCA" modified="2017-01-18" version="1">MASEQAVFDAEVREVEQFQKQPRFNNKLRSYSAADVVSKRGTLKLLYPSDVQAQKLHKILESKARGEGGGCTATYGALDPVQITQMAKYLETVYVSGWQSSSTASSSLEPGPDLADYPSNTVPNKVAQLFTAQLFHDRKQRFYRSQARAAGESLEPPVDYLRPIVADADTGHGGLTAVMKLTKMMVESGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLLAMRLQCDIMGTTNLLVCRTDSEAATLITTNIDPRDHAFILGSTNPDAGELNELMLKAESEGKSGATLQAIEDEWVSKAGLKLYPEVLAEALEKQGVDKSKIAEFVSKVSGTAHASHSATTSLAKSYGLTSLPFWSWDTPRSREGYYRYQGGTQCAINRAIAFAPYADLLWMETKSPIYSQAKEFADGVHKVHPGQWLAYNLSPSFNWEKAGLGKKEMKEYVWELGKLGFVFQFITLAGLHSNAYINDLFAKSFATEGMKAYVELIQGREREIGCDVLTHQKWSGADYADAMMMTVTGGVSSTAAMGKGVTESQFGGDDKKSSHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRS5</accession>
    <name>A0A1E3HRS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028101.1">
        <property type="nucleotide sequence ID" value="XM_019179925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRS5"/>
    <dbReference type="GeneID" id="30197161"/>
    <dbReference type="OrthoDB" id="2577521at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="58038" checksum="418AA4012F287407" modified="2017-01-18" version="1">MSTSPSKTPPLHCDLATLSPLPSEVISLIYAYYLAQNPLESRSQFLNLITLSKEVYSENAWKLYEAVELNDQNYQAFFDGLWSRGEIHVCQNSCPPYLRCEASAKALAREIEGYSHPKRRLKRPSHIPSKISYQKYEYESYIPFHLHPAIRKLLLIRQCRRIYIDSWCAFIELEKGNGSVRDAVNAWPLAHDIRHAESSRYTWISDPLFSSVTHLSFGETVSLEACHFSDERFAVKYKSFGPALKHVCLSFNDRFYDWETEYEEAARFGNLDECEERQSRKNITKLLRERLSFALRSELDEKTSLTLHNAWPDDIEPGLADTMIYELPRSTENGEDDWERQLAMTTWEMEDYMSELEKRMRDGSRGGDAWQPTIKPWKVRFTNVAPIPPDTDLISAVLDDYYPIGQDENFYGLFEKWWDEVVSFEGPVKCDCCEIFEKRHPKINAYKYSYNTRRENFESIRERADEVREHYEILQDAEAAFYESQYDSDEYFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVH6</accession>
    <name>A0A1E3HVH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028232.1">
        <property type="nucleotide sequence ID" value="XM_019179810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVH6"/>
    <dbReference type="GeneID" id="30197039"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="293"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="572" mass="62144" checksum="8E090950CFB4A51B" modified="2017-01-18" version="1">MLVLTETSVGFVVFKLSSDAKIDNKDLWKEFETPEGANKALKVQAIQRFTSTASAVEDLAAVQEGRLTDLLSKFIQEAVAGGEDGEKKKKKKKVEEMLVVSEAKLAGTINKTLSIPVLSDSSTQDLYRGIRQQLASLLGGVDQKDLNTMSLGLGHSLSRFKLKFSTDKVDTMVIQAIALLDDLDKEINIYAMRVKEWYGWHFPEMAKIIVDNIAYARVIKAMGFRTNAVHTDFSTLLPEELEATLKQAAELSMGTEIADSDLAHINQLSDQVISISEYRTQLSEYLRNRMQAIAPNLTALVGELVGARLISHAGSLMNLAKHPASTVQILGAEKALFRALKTKHDTPKYGLIYHASLIGQAPQKLKGKMARMVATKAALSIRVDALSDSDSRSEAAAAEVGIANRVKLESRLRALEHQAGIVSTRRVTAGSARQQPRFELNGAAGGSYNAASDNPTNPADLLPTQPSPAPAAAAASPEKKEKKEKKDKKRKSLAAEEVGDVTMDGDEVAGETKEERRARKEAKKAAKAAKKEGKEDGEGEKKSKKRRASEAAPAEGGDADGEKKKKKKKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7H1</accession>
    <name>A0A1E3I7H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028358.1">
        <property type="nucleotide sequence ID" value="XM_019179670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7H1"/>
    <dbReference type="GeneID" id="30196893"/>
    <dbReference type="OrthoDB" id="10337799at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="348" mass="39026" checksum="FAE5D308A650FF8D" modified="2017-01-18" version="1">MSGYFRSRLAPSLLQDSYRPFARGHSIATGYGTRLGGYAPSYLNSGSYLGRGAAVIDGAYSRYGTGYGSYGGYGYGGLDGFVGRELIAPTEVINTTVRAIAAPTIVERTREIPVPVIERHIENVHHHHHHDRVVERIVREPVHVPITERVSESHSHVNHHHGSTYPGVHTFPGHSHVHGHVHGFQGGLNATSWAGWSDRFRSLGSDFALPHLDRFPELFHTSHFRDTLLEYNNRYNLLPPSSIDRVLSLSPASLGEYIVSHGHEFGSFTDGGELILRGHPERPEYTLALLAYYGASRRLGQLSFPVRFAYGDSHVWSKLPTKFQSWLPTQLRPYPQPQYAYPVYDNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7I7</accession>
    <name>A0A1E3I7I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028343.1">
        <property type="nucleotide sequence ID" value="XM_019179655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7I7"/>
    <dbReference type="GeneID" id="30196878"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129598" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="78"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="37533" checksum="2428B9B71BD911F6" modified="2017-01-18" version="1">MRLRTHYLWGATLVARFGGHVLAQEAPSGDLPATSSVVSSLHAVQPAPPATGEPDGPKRVMYSQKELLSWTRHERRALEWEVQIAYEGQTFFDGWNWFTEDDPSNGLVNYVGRSKAFSDGLAFWTKDGIPGIQAEHWATTDVGAHRNSVRITTKSLFEGGLFIIDMALMPWGCGVWPAFWTLGADGAWPETGEIDIIEGVQANTNNHSMPGCAINSSTEDLYSGYMGNQDCDSSNVGGSGCSIISNSDSSFGMPFNEAGGGVFAMLWDNDGIRMWNWNRAQIPSDISDSTPSPSTWGLPVGTWDASICDLSSFFKAQILTLNVNICGDWIYNTWDREPLSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9M9</accession>
    <name>A0A1E3I9M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028454.1">
        <property type="nucleotide sequence ID" value="XM_019179597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9M9"/>
    <dbReference type="GeneID" id="30196818"/>
    <dbReference type="OrthoDB" id="2576552at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="142" mass="15346" checksum="1C1E746F269C4B05" modified="2017-01-18" version="1">MSTFKFLGIATVKALDTLPLSLLVVIFLACLALLQWPFPPSPSLLPTHTPPTYSEKLAGSHTFPSNPFPAASSQKALGHGHPQTQLYTVAVTTVNGQQQVVQVLQPSGKGRNVRRGSKQLREYRSGLGVLEEVDGEEAREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA67</accession>
    <name>A0A1E3IA67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028498.1">
        <property type="nucleotide sequence ID" value="XM_019179552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA67"/>
    <dbReference type="GeneID" id="30196770"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114133" checksum="2243B07DBAA75EEF" modified="2017-01-18" version="1">MPPDNRPASGSAPGASRKRSTAPKRNAIACLRCKERKARCVPAPPGSSPVPTCTNCLGARKECIYLDRTPNEIFLLEYVSQLESRCAALEMELRKHNPKSQFASDHTPAPVEAREAAVDKLNTVYPSGPPRPASDNAEAGPSTAPRNSAQAATIPLARFDDDPGKKGESGQSDEGDADEGDEADFALGIGMLSLGGGEEPVYVGPSSGVNWARVCASALKRPQGRSQPSHLSRFNYLAPPELASFKSALEYTLHHPTPPLPPPTLAAHYLNLVYDHVQARYGCFDWQTVRFWHENREAICQGRPLWGVGTGQDERRSLGAFFLWLCYGYGARLSEGENLPGTVNHEVYYNAAVACLSTLTSHHSLATVQALVLLTIYGFRHPTAEVSVWQVGGLSMRTAVEIGLHRRTRSKAEREKDPRRYEMKKRVFWAVYSLDRMMSAQLGRPSGIQDRDIDVELPLNVDVDFNQPKALAAMQSKQSELMGSKRPGDEYANGYGPVTSMTSAIHNIRLNQLKQMVTDAIYRLDKPLRPTNDVYSPERQSINEVDILLERLDQWRACHPDPPPDSQVPMLPKEHWELEYHNCVQMLLRPIIASRKAGKQYVGLCLESAVALCETQWQYLQPPVHHSKLSTWRFYRIFLAGMTLLHILTTFPTDMTEVELRRAEGGIRKCEAALGIWGERFRGAKRHEKLFKELVDAWETRVKEKTSGGDLQTSAFATFSTPSVHNRGRPKPLQPPSSSGQQQSAQATAPEPPVDIMSQFIHLVNNSHSAPQPTQLNGKELPTQMQALFGADVACSGGAGVRQSEALAQEQKARELLDAAGFDMRRLGMYSGMAPMANSGARQTSPDKWARTGADGNGAEWASDVTMDSAGPTFGNDGGLGIKEDFFSLISSFGIDTDTQTPLLPMDGSDPTFDFSAAHLGMSNVNYNYDPSPNAYDPMSHNSQTNSASAPPWAQSLAPINTGFNGFGGYNTLGQGMNLGTAGGSLQPGGGMGTGIASDPNMGMSDWALFGSIGNNSHQKGEASRSGNTNDSSEETVPQWGMSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAI7</accession>
    <name>A0A1E3IAI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028499.1">
        <property type="nucleotide sequence ID" value="XM_019179553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAI7"/>
    <dbReference type="GeneID" id="30196772"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="194" mass="22156" checksum="9CEFD9CC1F82CEA9" modified="2017-01-18" version="1">MTRTSRFRKLLQETRPVAPTLVGSPRRRWAERKEVARKRTSWLNLARTAYRLSNSSGGVCGHIKDLSTKGNIAPFFFLANSDERAQPQTTDRQGIPKETILIANDYERYLFERMTELEPKIPDGTFEDDRARPKVDGDVQKRARALLAAMHEDILRYISGGVNIRKRLDFDVMSVTRKSPRTTSDVLGGFECLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBF4</accession>
    <name>A0A1E3IBF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028418.1">
        <property type="nucleotide sequence ID" value="XM_019179561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBF4"/>
    <dbReference type="GeneID" id="30196780"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57351" checksum="B81794F8DE3939CF" modified="2017-01-18" version="1">MSRPHSPKPAPTETTSLLPPSPDADSRRKPWFPPVPRVLFTSFLLAMTFAVTQTSLIYAFRVMTCDEYYKTHEWDGREGDRCSVPKIEADSASQIALMSVITTSCTIGNLFFTSWFMKRYGCKAAMFQQTFWAALRNLTQIYALSIGGGTGMKIIQTTQLFNIIGSAGGYQIASNMFIATLVSVEERTAMFGVLSGIIFMGSSMGYSVGGLLFNWFGLLSPFQAAFGLLCFSTIFGSLFLPYIPPEDSAHSAAPEKKSKSFLSPLKIFIPAEKEIAGKSKRDYNLLLLGCGAFFSVLATGYVHMALQLVGTDVFGFQPGESGVMLSLNLMVKAFFLSICFPRIITQGRRWLSHRPSLPPSPQAYDHPESASQAEEPDSTGFPQQDPAPAPTDHKHGSLFDLHFLRWSIFVDGVLTSATTLSTKGWHLYVAAGVLPFASGTGSACKGVTLDFVEPELRADALSAIALVEKLAQVSTISIFGSVFALLSERGNPTLVFLLNGCTAIIAFMFLLFVRMPRPGEPRLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICG3</accession>
    <name>A0A1E3ICG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028679.1">
        <property type="nucleotide sequence ID" value="XM_019179323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICG3"/>
    <dbReference type="GeneID" id="30196531"/>
    <dbReference type="OrthoDB" id="10335869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="702" mass="76681" checksum="05E715356E365946" modified="2017-01-18" version="1">MTHEHQNVSLSSSSSPRFPREPTATTIPVINATTTPRSAAFTPAYDLSGATSVSTLSSKKTDAGKSTRGMGSARGGDTAGSAVVDGAAPRRSFTQPRVLTPSTAAGDISASPHSRERRYASLPPTFGPSHHSPFSPSHPSLPLGARAGTSHVERNCRVNVREEDGSRGEPRGDTLSLPPDASTLGDRRLLSIASIINPPSASRTFADLEPVHYLILKELFLLQPVKVICLSPYLYQIFIPLLYHTASLTYSLFSGLTGFSSKIPVFHALSFLEVLHIKDLNGLMIFCTYTLPAQHPWGHPLFPKLRRIIVHWDVIRSQAATTHALPQLHRSNQSPDRLSFHAPHPLPELVLHVELSNSCLWDTPAPYREIKALAYIFTPSSLILLLSHSGLAAPTTLNHPTSSYPSFSDVRYDWPRIIPSLPLHWPSAHTLKIIVEPDLIPPSWPDVKAVARREMAVRQDVGKSVWALVRDLEGQVRAMAQESLYVDTRAMGGAVFSGHAPAMFSSTSGGTSAPVAETGFTAASNATHHTPPSPPHPHTYTTTFFTQPTIVQPPRLPQLVAQVILHIPRAKSFEDASRSLIGESPWGMVARSESNQSEDEEKQGSTRDGGQDDEDLADEASLPRPLHPALVNYPCVLIHTDTASFFDGHALFEEFDEQDWGARSSWRKARVEGKEGGDCAWRVVFGPNECTPFILYPPRPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDC2</accession>
    <name>A0A1E3IDC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028742.1">
        <property type="nucleotide sequence ID" value="XM_019179261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDC2"/>
    <dbReference type="GeneID" id="30196464"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN86559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21191" checksum="7E8433B7D9C89321" modified="2017-01-18" version="1">MASVKIFSLAVKTLAKPIANTIKAQATQHETFRTICMGLAQRMHRTEARMRMGLLNAEAGNVKPLNDTRAIQNGATTLAETFLFLVGAGLIVGESIRSSKKESKRRDKVSDRLDGLEEEVKRLNGLLDEEREKGKGSVEEIRDRSDGMERVVTTIVQNGLKAGWLSLGHKDGEEGEIMKLLEANKTRSQVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE73</accession>
    <name>A0A1E3IE73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028800.1">
        <property type="nucleotide sequence ID" value="XM_019179183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE73"/>
    <dbReference type="GeneID" id="30196381"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129715" description="Pali-domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24497" checksum="0B971B6B275FA3D5" modified="2017-01-18" version="1">MALGPIHCGSFLLLAATVLLLVSSISAPVIHNISFLNINQGSSSEATFGVFGYCSNIIGSDSCSDRTLGYDIADVTGTLTNFSYVNDHLESLTKALILHPIATGIAFLSFLIALASDHIGFLFAAFVAFVAFVVSLAAMIIDFVMFGVVRHQVNDNTDASASFGTAIWLTLAATIVLFFSSFIVCFSCCTNRTRSRRDTEYAQPPMAQNGFERRRWWNRGQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEU6</accession>
    <name>A0A1E3IEU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028887.1">
        <property type="nucleotide sequence ID" value="XM_019179129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEU6"/>
    <dbReference type="GeneID" id="30196326"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="318" mass="33280" checksum="C8193B4BFB28A71E" modified="2017-01-18" version="1">MSSKPNVLLFGLGGIGGIYASILQLSQRCNVHVVARSSYQEVKENGFAIVSPKFGDHTGMKFAGVWKSTDEAAASGAEFSYILCASKALLDASPSLSDHLRPILNPSTSVVLLQNGVGAEAPLHKSFPDNTIISAVVWTGGKTLSDNSGVEQFNREGLTIGVDYRKGGDKTEEDAKLKTLVDWLAAGKGDCTLSGTAAAPAATLLKTGPFFASSDLALPLCYSIMNEVAAVAKAKGLTVPEGKVEELIKTCTDVEYPGLPSSMMADVKAGRPSEVGVILGVPVREGIRLGVSVPTITTLYTLIKAIDYRNQDSDAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGD7</accession>
    <name>A0A1E3IGD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029017.1">
        <property type="nucleotide sequence ID" value="XM_019178923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGD7"/>
    <dbReference type="GeneID" id="30196108"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21193" checksum="A5E80C59D97FE8B9" modified="2017-01-18" version="1">MPSPAFPGLFFAFCAMVLLIFVSVSPPAWERIHFLQASAGGQTTVFGVLGECLSGGGQCTDRNVGYDLQVWGADNLNINTTNFHRLTRALILHPIAGFFALLSLIFGALATACASRFLTIMMALSALFGLLITIAAFVLDMVFWSLVKNKINDAGYSASYGNANWLTAGALGAFALSFCTSLCGAFGRFASGRFAGEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGL9</accession>
    <name>A0A1E3IGL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029076.1">
        <property type="nucleotide sequence ID" value="XM_019178982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGL9"/>
    <dbReference type="GeneID" id="30196174"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN87733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="500" mass="53883" checksum="34E65FE9482134BA" modified="2017-01-18" version="1">MSDTQSPPRPGGGRPDSTLGDQFESRFAPQWHVGFGSSNERGGADEETVDTSPATTRRPSPLPEATSAPAAHEKEVEREASTMEELDELDEDSPAPVHDRHEEERKARQLMEEDAHLAKRRKQHPHGSSLPSPPPTTVPASAHHLTAGSCPGDGRCNGAGGKAGCEGCPTYNNSIASGLVSDRAPPTHGHPHSAPLSEGIDRPRYHETEGRPYGLDRFMEGVNNNLGRPTSLPSPSPDHVVQRQHESPVTTQPLQHPGSDKGTPSRFSPDSDDAPAGTTNGSGLAATPVGMSCRNCGTSTTPLWRRDEEGRPQCNACGLYHKLHGVPRPVAMKKTVIKRRKRVPAVSSGATATPSSSTTRAITAAPDQPSPVPTTAQMPSVTAPPAHVPPPIEDKMRVGSPPYAHRAPPSQHHTDHRGHHPHAQEFIQGRYAKPSSNSGNPGQGKKWWNDGRDREKEEKDREAREREGGFFLPFLGLGMCPFFSALEMVGWTEDDSESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHP9</accession>
    <name>A0A1E3IHP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029188.1">
        <property type="nucleotide sequence ID" value="XM_019178911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHP9"/>
    <dbReference type="GeneID" id="30196095"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="14930" checksum="4AB0217EC3DA417A" modified="2017-01-18" version="1">MSSPAIAARIAHVRLLVRAFPSTPLSGPAQLSNALDSILNRALAATKASSSSPQSGAAAGASAVEVIRAKAQEQKIAQTGAAVQRLKAGNAMRQYPLSKHIVTPVNDPLFYTRTRNAIHNAEKGIKRTWWKVFFNVKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHR7</accession>
    <name>A0A1E3IHR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029146.1">
        <property type="nucleotide sequence ID" value="XM_019178869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHR7"/>
    <dbReference type="GeneID" id="30196047"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="441" mass="48350" checksum="E6D756FCC0451B97" modified="2017-01-18" version="1">MSIGHPEWQAQIRQRLVDNQAHAEGYREIIQQYGKLAKSARDLKTRNKTLMKTGGGGGGEADGSNPLLKYLDQELTSLRSEISELYRSQAATQNKQLASAELLRERDEEVMNLRDEMRNLRDARDRLERKDQEWEQRWKAREVDMVTLSDEVMSLNLEISGISKREKALMADNANLLQRWIDKMNSQADMMNEDFEREKGGLAFAELKGDGEEGDAFEFVSAAGSETGDDETTPRKEKPKPRTSRPTSATSTTSSRAPPPNAKVPAAPAAKPTTTRTSLAPTAPRTAPRTSSTSKPPLPPVPAEKQSIKRSLTPRSSRPSLAPSPTPSTASTATTATQRTVRKPSGVSEVQKKEVTPKSTPDKDSPRARVTSQTSQVARRSPSSHSLGGKSVRDKIKAMEGSGTLKQPLPSPPKTGSTSPSKGKERQEVLRDSPKKGEGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3III7</accession>
    <name>A0A1E3III7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029089.1">
        <property type="nucleotide sequence ID" value="XM_019178995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3III7"/>
    <dbReference type="GeneID" id="30196187"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30781" checksum="DF6B6C307A9CAE7D" modified="2017-01-18" version="1">MGASVSQYADRWLPAPLNASPTAPPPQTLPASSPLSQPKGFMSYFIPSSEPTHKHRHPTVHDTQLIYAYIASRLPGELVGRVMDEAEIWPVCWRAQRAKMVCPSRVKGGINMLDGGLWETGQEAEVGEAAVERGLRCRNGEAWYLVSSPIGCFGEQEEEQEAGTEEHERRRKAWVKKVVIETSSRDQGWSDHRQHYGTYEGSHSWFEISLLRNDQEVPGSRAEIQFNVHAGQFFKEHTNVLLRDHPTLRLAKDGDRVVLWAKALYPGWVNAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIN7</accession>
    <name>A0A1E3IIN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029271.1">
        <property type="nucleotide sequence ID" value="XM_019178788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIN7"/>
    <dbReference type="GeneID" id="30195946"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="107"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="302"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="789" mass="88993" checksum="3AE8E373BCF2AB30" modified="2017-01-18" version="1">MSEPPAKRSKMESNTAPETNPYLAHRQEYQNGNGLSNGASGVTGSVDRKEHPLNGMVPRKVTVDQAKKIMDGEVNPFKNLSAWSSNYKKILEQRKGLPVYQKMQEFLSVFNENQIVVMEGQTGSGKTTQIPQFVCYSDLPMLRGKMVACTQPRRVAAMSVAKRVADEMDAVQLGKQVGYSIRFEDMTEQGTTFLKYMTDGMLLREAMNDPLLERYSTVILDEAHERTLATDILMGLLKDIAKRRPDLKIIVMSATLDVAKFQKYFGDTNPTGLAPVVKVSGRTFPVETFFTQEPENDYVEAAIRTVLFIHQAEDEGDVLLFLTGEEEIEDACRKIRAEGEELANKGMAGPILAVPLYSSLPPHQQQRIFDNAPPAGKDGLPGRKVVISTNIAETSLTIDGIVYVVDPGFCKQKVYNPRVRLESLLVTPISKASAMQRAGRAGRTRPGKCFRLYTERDFVKELEEQTHPEILRSNLSNTVLELIKLGIKDLVHFDYMDAPAPETIMRALELLHYLAALDDEGNLTPLGAIMAEFPLDPQLAKMLIVSPEFGCSNEVLSLTAMLSVPNVFMRPASQRKEADLAKAQFSHPDGDHLTLLNVYHAYKSNEDDAKNWCWQNYLNQRSLAQADNVRTQLKRAMEKFDLELCSTAWEDRNYWNNIRQALTCGFFMQVAHKEGEKGSYMTVKDNQVVRLHLSCGMDTTPEWVLYNEFVLTTANFIRTVTEVRPEWLLEYAAEYFDPESFPANSETRRALQRVLDRKLGKVSSSGHGKDRKEKKDRDGKDKKKKRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIZ3</accession>
    <name>A0A1E3IIZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029224.1">
        <property type="nucleotide sequence ID" value="XM_019178741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIZ3"/>
    <dbReference type="GeneID" id="30195898"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114572" checksum="42232D4911E45F97" modified="2017-01-18" version="1">MTLHPARSHHTHRNTRHRSVSRSSSSPSPPPPSSLSVHGHPPRTSTPLHNSREKRKSFNSPRSSATGSVGHNHGHSHNSHRTRAPSRSPLPPSYNPPSDLPSSPLASHPTLEDQQDHETTDVGFSTQYGASASSVAGAGSGSEREYLRGDETEVERASRVVWKKQIEEPVDRTPTPLGSARTSNSARRQNSAPPSPSPYTLLPFMIGLNHVIAFNLGGKTRRIGLSISMTRRKCENLLVLSAVCWGIWVLGYRWGEQAIAGEIGLLVGLTILYSALRFRPTPARVLSTYLPPTRPLSPSPLPPSTWGSTYPARERSARSSVGHTSLFLAGGHAGYAGYSGAGGGGQTSPALPKDDPRARMLLPDEDGYIGIGHKGSIWGTEEREYRDCLDDGIYYALLLGPLVASALLHASLSQLFSYPSSPLPYGNWKIENPLVLPTTPLRRDVDPTRGPIETIRALSALATSRRNLVQLFTLCSFVLLVHLARSLHLEIKQMRLLCPPPNDPSVSELGEPPGIPSGHGGGGGGSGSIGGRFSAQQAGFGTFWLRKGEWRRTGSVVGFSGLVSAGCLGVKAVTAYVGRGVWSDMSPSDIVIATLFYQFSIYVCVRLARKGLTLGELASVCSAATAMFMEVVNLTRMKIAIFRTPYIKTYRLPTPLLTFQLALIPGSLLAGFLLSPLLYLSRNLAQKPAHRLRLPHEKPIHRRLLALGFYGGSAVVCGGLVGGWTWWCLGGRNPYSWVFWFVFGGRHMWTRLGLVGYWVGLAVVSVAGWERQLNRARRHRRYTVPGTAAGRGDTLSSSNSNSNSNHTHPSVSTSTSTSTLPNVPSAPGHPGQTAGQVEGRGQAGFSGAATQMMDAADQRMPTLSVNARRKSFHALAVIMFIPGIAVDPAFTHLSFSVAFAAFNFAEYIRYFALWPFGVKVHLFLNEFLDAKDSGTAILSHFYLLAGCASPLWFEGPSELLSYFGVLSLGIGDALASIVGRRIGRLRWCPAFGKTVEGSLAFFLSVLVSSVVMWAVGAVDSFNLVPYTITVAFVTLLEAFSAQNDNLILPMIGWAVGTLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJR3</accession>
    <name>A0A1E3IJR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029388.1">
        <property type="nucleotide sequence ID" value="XM_019178687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJR3"/>
    <dbReference type="GeneID" id="30195844"/>
    <dbReference type="OrthoDB" id="10369625at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="237" mass="26087" checksum="3AF49338C5230096" modified="2017-01-18" version="1">MGRKKRDYKGIKNSARKGANKGGDKGASKPKFLYGFDRYAFDDPETAPLRKNVQGKLMASKLVKPTYTKMEKHLAIFCGRLTKAESVGTGYTELDRCALFIDSLPLEVPEFSAAYAAFRESDAPTWNECLGIYKSLLALRTPPNPPKKLVTGGKERKGKKNKGAPGLCPRCKTNWHQGSGCPDSKRSTSPETENESVMDGENKDEREDAGVHVTGVEDFGSGAESEDFVENSVENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKS6</accession>
    <name>A0A1E3IKS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029488.1">
        <property type="nucleotide sequence ID" value="XM_019178581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKS6"/>
    <dbReference type="GeneID" id="30195738"/>
    <dbReference type="OrthoDB" id="2564969at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="278" mass="30421" checksum="3AAE5BD1A3DA948C" modified="2017-01-18" version="1">MADSKDETKEAKAKAEAKAKAKAKAKAEQAKRDKDAKTSSKPRSSAEIRNEELIVLIISTLTTHAPLLLGPTSSLALLLHISLKHGLVLILSVFFLLHLYLPLFALPHFSAVLTLVCPLIATINILLHELGRPGSFSKAKTKRADGAQFLGYWLVYIVLGWMRGWVGIYRPGWKGVFEVGRSGILVAAGGGWFSRSALKSEKSKELLEAEKRETEEEQKAAAKKAKEEKAQKEKEAKAKEKARKAAEDKAKKEKEAKAKKAAEAKAKAEADKKKNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKV3</accession>
    <name>A0A1E3IKV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide riboside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029507.1">
        <property type="nucleotide sequence ID" value="XM_019178600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKV3"/>
    <dbReference type="GeneID" id="30195757"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002582">
        <property type="entry name" value="Nicotinamide riboside kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="262" mass="29152" checksum="0CB54D7ED9F8CB16" modified="2017-01-18" version="1">MVTHKVVLIGIGGASCSGKTLLAKHISQALPQNAIIIHQDDFCPPAEQVPYSKEYPDLQDWDDPSSCILWQKLQGFLAKVRQTGRVESHSSHDHLNKQNKIPIDQVVFERWAEAFRSLDAEQRQKGVELIWVIVDGFVLYWDKLVTDMLDIRIFLQVPPILRHDDRHRLNLATDPDDAAEGGVWTDPPDYFDKIVWPGYLKAHSHVLDGPGLTQLKPEWGPKGLDLHVICPGEGADGLSEAFGKSCQAVLKGVESGKGSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL49</accession>
    <name>A0A1E3IL49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029450.1">
        <property type="nucleotide sequence ID" value="XM_019178543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL49"/>
    <dbReference type="GeneID" id="30195699"/>
    <dbReference type="OrthoDB" id="10415028at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="848" mass="92296" checksum="5CBCE7ABBB437A67" modified="2017-01-18" version="1">MIPFIVHGIVTVWTAIAVYQMDIIHQNHFAIMADAFFHPALPIIPLLIVYSISAPSVYKVPELPSASFTSASSVSLGWPAFPTPDGGALQPFLTYTEDGELLNTVASGPGAAKIMAEQLIHLTGAVVVSFLALLGGMKRVLNEHIGQAINELKASFAEGCRRYKVALEFYETLKGELVRTMSFRYLRFFKDLQPPAPPTPEFGVHVPRHAPIRRALLCHPPGHVSLESAVVVKISWPQNFLGRWSLQTSLGAPVSPPRLILGPSLPSAPAAQSTEKDRSITKDSTSSSSVLEANRESSSPVNDLLELSCQADDPSNPSRSPGDTELIHEAKVNLECRMERQASVGREVKERAHSTIDNTDTRQKTYTGPPADSSPSSDTSTSTTIDSNIGNTELPSTGNPPPRPIGEGTPEEADSSTGPQPSHPIGDDSTSSQASSDAVSTKIDTRAHTAGTGDVAENTGDERATSGPDPRHPIEVAPPFASAPSSSSSSISSPSPDDEPTRPGSNSDSDDGDDGDATEESSGPQATDTARAAESSRAPPVLVAPISYPENSGVQRMPGYWPIRHNTTRFSDSLPRRIRSSYQRHSHPRSIHDTYRAAARRPSSRRFTTPRNINSSSGDVRSSLLDRYTSIPRILRHEHRRVSRLGPHDMEEVQPAPVEEAIDEMGERLPQQIHPPSYERFDSNPAPPYFGYSEGHLDPDPPPLYHHHVPRNDMLAQHGREDPLDRAGLGEIEHHASAMALDNRVLGWLQQQNIQRATGRMDNDVAGWPAHNPYDHLPAPFFQGEPVALPSQLQDPAVTVYQNMNAGHVVPESYARQIVREEIPPQDAVPPLQDVLNQEKQGHIDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM02</accession>
    <name>A0A1E3IM02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">STE/STE20/YSK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029536.1">
        <property type="nucleotide sequence ID" value="XM_019178380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM02"/>
    <dbReference type="GeneID" id="30195526"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="874" mass="93361" checksum="CF19300068F8ECD1" modified="2017-01-18" version="1">MPPPNPHSREQAYLTALQSQLKDVNPDTIYEKLEIAGKGAYGAVYKGRHVASGHVVALKIINLDTEDDEVDDIQKEISLLQQLMLGSASAGGAPQNVTKYYGSMMEGPRVWIVMEYAEGGSIRTLSRAQPLKELHICLIIREVLIALAFLHKNGVIHRDIKAANILLTTQPLRILLCDFGVAALLQSNTSKRSTFVGTPYWMAPEVVTEGKMYDSKADIWSLGITLLEMAYGEPPMSGQPAARAVMLLGDKRMRAPRLEGDHWSKEMRDFVVGCLNEDAADRLSAEELSKSRWIKQQVKTPLTQLNDLIARFQAWKDSGGQRMSLAAGVGASIDDDEYDEMPNGDWAFDTVRSRASMMLLDQKAQAGEVDKSLLPPTARPAPHSLRRLFHDETSSDPDPFQSFAHQQPPTPQSSEDNGTVKQTGRFASPEADDPSSREGSPPKNEFDGQTIRQARLGRDGRSPTPLMIKTDQVPSINLPLPSADSNATSATYHPDELEPTPIASRGDGPVPSPRPIRNKMSLDNLPSAASFNSQPPTSKSSMQLGLEDRSKSSLGMSRPGGGEPRDGLRGFQFPLMGQSGPPPAGVSKLQPPHLGRNHSAAPAFPSALHGDTSQSTLPSASPTAPSFPGLSPRPPMMRQASVAVMENRSAAQSHAQAAQAQALALAHGHEGGAGPHKGLAVPGGMAGIGLGRPGQQGTSQGMARTRSGSRADDGPNVGLRDLLKLTPAAPGMQDLLPPSPSVSTTPHKLSPRPQQTHNQPGSIPAYPAFPGAVSSASLPMSKTPSLASLASTVPASAPAPKLGPVSTSTGLQNDWGPIPDVRLGPPIRPLDLGHLDSQDVFTELESLVDDMQSWLGCVENGLEDLLRLPESTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM71</accession>
    <name>A0A1E3IM71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029612.1">
        <property type="nucleotide sequence ID" value="XM_019178456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM71"/>
    <dbReference type="GeneID" id="30195606"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="124" mass="13542" checksum="17CDBB4C583DD737" modified="2017-01-18" version="1">MAPKTVQPAAVTSKNIQTSLDILIDNYTSTTPARVKLIDAFLFFIMVSGILQFAYRLLITVYPFHAFAGGFGSTIGQFVLLAGLRAQITPGRDGEFKEVSQERAFADFCAASVVLHLFAFNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM99</accession>
    <name>A0A1E3IM99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029389.1">
        <property type="nucleotide sequence ID" value="XM_019178688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM99"/>
    <dbReference type="GeneID" id="30195845"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14436" checksum="E6108FE626BBFA45" modified="2017-01-18" version="1">MLIERSKTPMFIVSFLSELETLTPAGTYGLYLGFSTVFFIFIIFFYPETKQLSIDETSMLFEDDWGVARSRRMRRERDETRRRFADAEMAEVAEATLEARQDKHRGISASELKDFMSGLKNGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMP2</accession>
    <name>A0A1E3IMP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029594.1">
        <property type="nucleotide sequence ID" value="XM_019178438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMP2"/>
    <dbReference type="GeneID" id="30195587"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="532" mass="58110" checksum="D5C1457E6ED36DF1" modified="2017-01-18" version="1">MTYNLDPLPETATHKDYTRIHFDTANVPAKRIVGLLACQRDPLLHKMRTKVYAAREASVTAPPPPKGKAKQKKGAAPVNGDARPEEKGKLWEVELLDTVIFPEVGGGQPSDTGVIRLLNPNGGVTQEFPVEMCLRKKLDSVHLVRIPLGVEVEGGWEGREVEVETDWDRRFDQMSIHTSQHLISALANTHYGLSTLSWSMQPYPSLDPPYIELARALTVEEALHLEQLCGEAIKQAKKIWVDFSIQGQEAGGELQGEGAVATREFRELPKDYSGGVIRHINIQDTDRNACCGTQSPNLALLSLFHVIPPTPSTSKKDTPTKLLFLSGPRAITALQESSRILSAAARTVGASRADVVQRLERSELARKETSDSLKGVRGELAKLVAEQAIRQGKESQAIAVVSREEKGTHDFEWLGLVGSTYLEAFKNASLEDASSPKPLIVLVSALNPAVSSSVPSQSFLIVQSLDDALAKAVNEKIKTALEGRVKGGGARGKYMSKVDGKWGKAENQMVEEIADEFKKEASWQSMPDGHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INH4</accession>
    <name>A0A1E3INH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol polyphosphate-5-phosphatase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029679.1">
        <property type="nucleotide sequence ID" value="XM_019178241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INH4"/>
    <dbReference type="GeneID" id="30195387"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="679"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="904" mass="100423" checksum="5A8CB737ABC45E01" modified="2017-01-18" version="1">MPPSPYLPPRFTVPPLPPTLHRRMNLLPHDAGIILAPPGGAPGVLIGWGVRGKIEPLDGAEEGELVLGGVLGIARLWDAAYLFVFLPRTGTPLFPPHDDDEPSHEVYTLGDIHAIPLTRDGSAVSIKRLIALQESRKPKPKATSRWSLAIPISGAGALPQERDHLAASSDEDDDDDEPLTPEADESPIPTKARQWTKFIPKFRKRSESSAEPPKRQELEEKIVRQIKREFENGFFFSYDFDITHSLQAKRHTVSQRAASGAALADLIPKENSLFPPSVASTLRSSNDTPTGHSTGEDFVEPDIYVPLWRRADKRFFWNEYLMKDFIDLGLHSYVVPVMQGWVQSSTFTIPIPPSPLDPTAQTSGVPVDIAVISRRSKDRAGLRYQRRGIDDNGHVANMVETEMTVRAKVEGKMSLFSFTQVRGSIPLRWSQSPYSMKPPPVLNEPVDKTYAVANLHFNDLVSRYGHITIINLSEQHGKEAPITNGYKQLTTELERDDVTYTEFDFHAKCSGMKWENIVELVDSLDFETMGYLWTLQGEALREQQGAFRTNCIDCLDRTNVVQSAIARRVLVHMLIQLGLQAEGPVVENVFNDIWANNGDMISLCYAHTSALKGDFVRTGKRDFSGMLHDGVSSLSRMFYGAISDFFAQAVISFLLGHRNLAVFSEFLETLTSEDAASVIKLDRLRNVAIETCSARVLSEGEDKIGGWILLSPEAKSTKISSATEEKILILTQKAIYVASFNYSLEKVTEFTRIPLASITQIQRGAYILSTLQEASRDPKENAGLIIQFSPADESTRYSTYSLRNKAPPPSATSSEHPLHTPLPSVEHASIDPLAKEFFAFKALPGQSGDATCMETVKDIVSQLEKACKRDGLVVEKDIVSLTEAESSTTLLAKMDYAFKRALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INX1</accession>
    <name>A0A1E3INX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029760.1">
        <property type="nucleotide sequence ID" value="XM_019178322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INX1"/>
    <dbReference type="GeneID" id="30195468"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14583" checksum="0B675821A74E18EC" modified="2017-01-18" version="1">MPAHIPIVKKRTKHFKRHQSDRYHGVKESWRKPKGIDNRVRRRFSGQIPMPKIGYGSNAKTRHLLPSGHKELLVHNLSELELLLMHSGKYAASIAHGVSSKKRVEIIARAKVLGVKVTNAAAKLRTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ29</accession>
    <name>A0A1E3IQ29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029812.1">
        <property type="nucleotide sequence ID" value="XM_019178093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ29"/>
    <dbReference type="GeneID" id="30195238"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000159">
        <property type="entry name" value="Related to DnaJ protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="37139" checksum="455706310071D5F5" modified="2017-01-18" version="1">MDDADPISNFFPEATASDQSSILYAALSLTSTATPEEIRKSYRRLALQFHPDKHSSKSDSEKEEKAKQFQRIGFAYAVLSDEGRKKRYDKTGRTDDKFAGAEEMGWDAYFESLYKRVDRKVLDDDKLKYQGSDEEKDDIISAFNHTSGSLPDILSYVPHSTHQDEERFVTLINELIDEGELDSTPKWKKTSTDEKARAKRAKAGEKAAKEAEKAAKELGVWDEFYGTGAKGKRQGDKEKKEEGGGDGSLQALILKRQRDREGALDAMEEKYRKLDEEARATKKAKKGKGKKEDAGEPPELSEADFEALQAKMTGKKDSESKPKKKSGKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRX0</accession>
    <name>A0A1E3IRX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029983.1">
        <property type="nucleotide sequence ID" value="XM_019177944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRX0"/>
    <dbReference type="GeneID" id="30195080"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="31838" checksum="9EC2735A0207E969" modified="2017-01-18" version="1">MSNVTQGVKEFFSGSTKPETTEVCTESAPEVVQEHVRPQEHVKTADAIDRERHVHHHQHRVQPVADSQTLPEKHIHSTAPIVHTEHTEDMLPEHQQTLQQQRGLHQSQKTEGGVERSGEHVGVAVNEHAHHHIHETIQPVIQRETVAPTVVHKTNAVHETVKEAPIVHEVTTLPTVSAAEYAQTREEPGQGVCRTYEGGPAVAGSGAGAAGAGTHGLGKTGTGIGHSSQSGTTGTTGTGIGHSSHSGTTGTGIGHSSHSPHSSSTTPGLNTTSGTTGTTGTGTGKSHSKTEAAAAGVAAHEAKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRZ0</accession>
    <name>A0A1E3IRZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monocarboxylic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029996.1">
        <property type="nucleotide sequence ID" value="XM_019177957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRZ0"/>
    <dbReference type="GeneID" id="30195094"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="53951" checksum="8445F87ECF09CBEA" modified="2017-01-18" version="1">MTPVSNLAELSYNQSHPEPAHSIIMTPMSEYSEYDFSESVPATPVAWTPATEYSEHDLFATAQSRNSRHAAIVNRIDERGPEDAEPSYALPPVDEGWRAWLFLFAATVIVLLVWGLPFSVGILALYWNDTLFKNQGGLATLTLASTLQTGLLYICTAAAGFLMPALPRWRRELQFFGLLFAVLSMIASAFATKPVHILLCFGCVYPFSGITYMPCITLVFEWFHTRRGLATGILYAGTGLGGIIMPFLVSFLLDKVGYKATMIGFGLGYALVGSAAILAIRPRIPIVPNSHGQRERRGGNINWASLKSRGFIVGTTMVFLMSLGNFIPSLWLPSYANALNLTNPNGTIILVILNASSIPGNALMGYLSDRIPLKLVMLFNLSMAALSCAILWGFGTNGGMLVGFSIIFGALGLSFATLWTGMISVIAKDDPVAPPLVLAIFTLVRGIGSLVCGPISQSLLKLTALNGKASGAYGLHNYGILIIYATVTILASGATGLMWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS83</accession>
    <name>A0A1E3IS83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029878.1">
        <property type="nucleotide sequence ID" value="XM_019178159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS83"/>
    <dbReference type="GeneID" id="30195305"/>
    <dbReference type="OrthoDB" id="2578184at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="40862" checksum="CC0F44A9EFFB4A1B" modified="2017-01-18" version="1">MTSPQPTEKSASPAPPSQKQGTITSLTPSDVEANRWMDERKLKKQKPLTEFAIKELVWMEIFRRAKQDSRLSGVNVKIETPGYWKNRWYHLARDWYQPIVDARRKYGHDFYDGMLQLTEKEWEERIKANSAYKKLRETPFHHFDAMHYILDGQSASGVNAGPTFPRSSGETPSGPLSLQRSRSLSLSPSSEPSGRRAAQDYGAEIVLERKRKATEQKDDSEDDDDGSEEDEHEESQVNKKEKRARRGWPRRDIEKKEEEEELAVDAMARAVLGMQSSIDKYLSEQRQVANPRSSRLSTIASWLEKREDFDDPTKRRILDKCLNDEGCAEKVMLLASGCEVKLLEERILEQIRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISB8</accession>
    <name>A0A1E3ISB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030054.1">
        <property type="nucleotide sequence ID" value="XM_019178015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195154"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="129"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1322" mass="145775" checksum="65D9127AA5D1468A" modified="2017-01-18" version="1">MAPFPSPAKPRPISRHRSAEPLPPPLPPKAIDLNSSTRSADQETSSKVTRRAFLCDVVVEKQGEETANLLAHLGEPLQPLSTLPAPDTSSKSSPTTPSRLSRPSDADDEEREDAVPAWTAAKRHEMEKRLENLIDELVRTEKSYYSRIHALKTAYADRLRLYSKDPNQALIPPYEAKAMFANIEAIVPACHSFYTDLCEMLAAGRAEDTVGDVCLKHFKTLRTFDPYRTYLSKQDESQKLFQESLKKFSGFASFIESTKYQTTGIGNIGLRELLMEPVQRVPRYTLLWQTMIKCMSPLSTQRAKLLEAIAIASRIARCEPDPQTVRATVMYNLERNIDDFPAKLFSNNRDYIDAIDVEDNPAEYPTMQSPNGRPLNSATPPLHCTLFLFDDKLMIVKRQSASISGRKVTGTDDVQRLVKSGGGIAVKEKNNGKRDKLSFKGEVDVLDVMASDVGNGEFHLFFKNPPVDQSGRWSGRAFRSYSTVHPPYSVSLDPIATKRDKMRFIHNLWAAQALARAKILPSTENRAVPKVLQSEQEVDFEGAQLERARCFWDVWDRSTWGGQRLARVVVHVDEDGEAPELLLDPRRQELSVYLQPMAGGLCRYAHSVPGEEEGERAVIEMSEVRAKIASTIHEHGIFKFRTGTTSCPTTPSTGTHRYRPSMLNLDTISRNLFGASSVSGRSGTSSDMFSTSSSKRNSRPAMSRSSTLETSLCSMEGPEEKEKEKEPSKKRFSKMPASPESAGLIAGAPYPSGTEKIGQSEKDLNSRLDVARQNSHSASLSPRPSSTSVKTAKLGSKSVAELRRSHEELAEKTVARVNTSRTPSPLPHLSPTPATGRTPSPRRPLSSETDATPQARSLPTPKPSLAVNTAPLVIRKTPSRTQTLRSEGSIASPHRVPSPAPNGATLSSQPSLSRPSGPRGPAPRSPQPHPPPLATASSASSSVSTGSTPSAIGSGHTRLRIVSGNGRRISLNRETIPLKGDEENTSPATNTPTSHNLPLSIKRQHSADCLSPRKRSPSLNKSPLLETPLQPLVIRRTSAQMSGASTPRRTSGLANSRTVSASQHSITSVASADTVNTVATTSAEDVEMKEHADVVSAVDATLKKIHDARGSTKRLKSEMSSLRKQMVKDTVKSKESLSVKMDRQGSLPRSPHKRNMSRIADHDINDPSLHRQPSQSKKEIDTIVMDECARGIVQIVQRVDGHLKQAETDAGQAAQLARKVMGENDEKMQEMVSMRNQLHRSREHNELLQRQLGDSQIELDVVYEAFNTELDGMFNDAQLPETEAFQALRNDLQVTKANRNVLQLENQKLKRELEEANLKREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITV8</accession>
    <name>A0A1E3ITV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030153.1">
        <property type="nucleotide sequence ID" value="XM_019177769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194903"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1420" mass="159694" checksum="8F955D8E3E60529D" modified="2017-01-18" version="1">MASPPSFSSFPDFPAASGKARQDPQAEHVPTFSSFPDLPGPSLSSRDDGHRQKRDNEREDLDKRDRRKRKDREDGREERVDRRRRNRHGERERERSRSRERRRGDRHRHEKDSHRDQSPEGRKKEERRRREREEAQALVRGDVKRPEERTSKRKEREKSEERWVKDDDDGTPWYETLGGGKKVGSSDKSYDPSKALFLDTAGDRDIVRYGATTSHSTPRYYRDGNNRVMGWNEGIRVVYSRDRTQKGIELAPKGRPYVPRYNKHIRSATSHIYRILLPPSSDRQLDYDTSFVAFDSRPKRLEEPDLPSYRSITHQDLPDEGKGGEYELVEDAIGSFATAEQEVRKKTVDMERRLKEQPGDEDAWIEYSTLHLQLSPEAERVPGIDPTRLATTKAQAEVTLSILSRALNATPENGYSISLHLAYIRSAEKIWPGRKVTERWKNVLRELGQASDRRPGLEEGMMKLWLGYIEWREGQGFGKGDGEESGGGVDEVTDVYVECIERLKNGMGEDALAREENLVYLFLRACLFMKQAGYQERALAAFQALMEITFFKPDHLRHQPHPSQREEWFTSVTSTFEEFWDSEAPRIGEPGSMGWHNTPANTPPPPSVLRDPLVYKSEDPYKRWLETELRAETLFARPGRATDLDDELEDDPFHIVVFSDLSPFLFPIFSPEARLQLIYAFLTFLGLPFTPPGVPSASPANADPHLQWLLAANQSARMTFWPPKPSVKRIHWQTVAGEPMDPERPLSISSPFSCPVKNWAQTRSTLFAKSTGSGAWFRDLERIDLEGVDVEVVREVFRIMGPLVPDPGFTLAGFAVEAALSPKNAIKAAKSILSQDRTNLVLWDGYARLERQRGNASTARTVYITALQAAKQEREEREKTEDEMDLWAGWAEMEFEEGDKKRCLDVVVMAAGIGEDRISKCIHSHYEASTPSPLSLLKTRQYYHRLAPTGSALLLSSLLTYLVDGIDTTCDALLDISSAHPTSSSECEEALQLLSQIMFRHATFTPSMPAYLSRQVLERALGAFSNNTALLSLYMYGELHNRVYGRVQRLIGEMTAESSANAEGKGVVGYLWAVWAEAVAAHRTFWDAGGGGAERVRMALDKGVNSSRGRYCAALWTLYIEFEVHMGRAASAKQLCYRAVASLGACKRLYLLPFSRALRPHFSGVELAGWSELAIERGLRVRDASGLWDTEMAPDPPSCSSIMSTIRASGILFDLDGTLISSTPVCEAVWHQWAKQYPVNLEEVFKTSHGIRTRDLLRYWLKITDPIALEAATEKFESDVLLESQRLAREGQGGITLLPGVEKMLLSLSSPADDNARWAIVTSATNAYATNAINTLDLPKTSHLITADEVTRGKPHPEPYIMGAAALGLHPTECVVFEDAPTGIKAGVSSGAKVIAVCTSHPRTALEGLGAHMIVDDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT3</accession>
    <name>A0A1E3IVT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonhistone protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030357.1">
        <property type="nucleotide sequence ID" value="XM_019177606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT3"/>
    <dbReference type="GeneID" id="30194737"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25757" checksum="622770DFE037BEA8" modified="2017-01-18" version="1">MSAPSWEEMEGKRLEMINSFREVAAAMTNCVKVIDEYTSLSPVHLSKPDLLQPLTAGGPLAQALASGLGDPSYGGGINPATGKKERKKKEKKIKDPNAPKRPPSAYILFQNDVRDEIRRSNPNIAYKEILHIISAKWKDLADDQKKVYEDAYQNAHSTFRAEEEAYTSKKDFPVPPPVAAEEDFSSDSDSDSSSEESVVPAPTTLASATATDKKEKKRKNKEEEASKKKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVZ9</accession>
    <name>A0A1E3IVZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030355.1">
        <property type="nucleotide sequence ID" value="XM_019177604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVZ9"/>
    <dbReference type="GeneID" id="30194735"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="171"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="952" mass="104576" checksum="9856C5A891C3D302" modified="2017-01-18" version="1">MGIQARNTAARMPSNADLEKAPFIEHDEDDVKPRRRSHVHTLPMMLALFGVLYLLKTHYDTSFPFPSKPAPLPDFIRDGIEQCEIISRPPPHHKPFTASREKNERFVEGTKSVLLKNGTVWTGEDDGQEILHGADVFLENGVVRKIGSGLDLAEHLKDKNYDQVELDGAWVTPGIVDTHSHMGLDSAPGLRGSDDTNSRRGNTQPWLRSFDGFNTHDLAFNLSISGGITTMLVLPGSAGSIGGQAAVFKPRWTNENTPQSMQLEPPFVIDTAGNGTLKRTKAWRHIKHACGENPARVYGANRMDAAYDFRKAYAEGKKIKDEQDRWCADPKSQKEPYPTSLEWEALADVIRGNVKVNIHCYETTDLNSLVRISNEYQFPIAAFHHAHEVYLVTDLLKQAWGPVPPAVAIFSTNGRYKRESYRGTEFAPKIIADNGLDVIFKSDHPVLDSRYLVYEASQGHHYGLNFSHALGAVTTHPAKAMGLDHRIGHVREGYDADIVVWDSFPLSLGATPKQTYIDGIPQIIKPHVVDKPAEAQQVFPEGKWDEEIAEVLQTRGDPDLRPKKSADNVFFQDVSGFYLKSKHDLSAFENGGKGDVVVKNGEITCVGKCVAEEGLEFEIIDLKGGSIAPGLISVGSYLGLMEIRGEKSTWDGVAYDSLKDAGELTDGLLVHAVDGAKFGGKDELTAYRSGITTAVAPPISNSLVAGLSFSFSPSAPHPLARDAIQNPAAALHISLDGGSGSTSTKIAILRRLLLGQVHEDTEVVKAFKKVARGELRLVVEVRQADVMSALVRLKKEVGGEGKWTFLGGHETWLIAEELADANIGVIVAPARSYPEEWSERRIIPGPPLSNHTLPSYLASHGVTVGLGIVEEWQARNTRYDAAWVYANSPDIFSKSSALALVSDNLEELLGLNDAYKAREEEKAWVAYEGDMFGFEGRVKGVRGFGKEEIDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW80</accession>
    <name>A0A1E3IW80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_05478</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030312.1">
        <property type="nucleotide sequence ID" value="XM_019177561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194691"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="244"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1590"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1590"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1635"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1695"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1763"/>
            <end position="1777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN92685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1784" mass="196369" checksum="210E63078CDE1AD1" modified="2017-01-18" version="1">MTVTFPYSSAPTKQVKEIQFGIMSPEEIKAFSVAKIEYTEVMDENGKQKVGGLMDPKMGTIDRNFKCQTCLEGMAECPGHFGHIELARPVFHQGYIVKVKKILECVCFSCGKLKVDTRDPMVANAVRRIKAQHRLKAIWALAKDKKICEPDELDEKNGDSTFEDEHLQEQQVKGHGGCGHEQPLWRKKGLKLNGVWKPTDKGDEEAAEPEERNISPGEVYNILKKITPEDLHIMGLNAEYARPDWMILTVMPVPPAAVRPSIAVDGGAMRSEDDLTYKLSQIIKFNGVVRRMEAEGVPPSVVNEQFDLLQYHVCTYMDNDIAGLPRDQQKGGRAIKAIRARLKGKEGRMRGNLMGKRVDFSARTVITGDPNLQLDQVGVPKSIAMTLTYPERVTPYNIVYLQMLVNNGPATYPGARYYVKDTGERVDLKYRKGGEPISLQFGWIVERHLKDGDFVLFNRQPSLHKMSMMSHRVKLMNYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQIAWVPRQIVSPQANKPVMGIVQDTLCGIRKFTLRDNFLDWLQVQHILLWLPEWDGTIPPPAIFKPKPLWTGKQLISMTIPKGINITYKNNEKPSPIDVTDENVLIEDGELVHGTIVKNMAGSANNGLVHVIFRELGHIAARDFFSAVQRVVNYWLLHFGFSVGIGDTIVDKATMAGITNRMVEAKEAVQKLVSEAEANRMKPKPGMTIRETLEASIANELNKARDWTGKTTQDNLKDDNNVKQMVVSGAKGSFINISQMSGVVGQQFVEGKRISFGFRHRSLPHFSRDDYGPESRGFVENSYLRGLTPQEFWFHAMGGREGLIDTAVKTAETGYIQRRLVKAMEDLKVAYDGTVRNSVGEVVQFLYGEDGMDGAAMEKQSLDIIRLSDRAFERRYKIDVLGNSGFSRGTLQAGIDQSSVSLQKLLDEEFEQLTDNRRVLREEIYEDGTPGHPLPVNIQRVIQNSQQIFHIDPRVPSDLDPVYLLQERNALASRLMVVRGDDKLSKAAQRNATLVFNMLLRSHLAVRRVLEEYHLNTEAFDWVIGEVEQIFNKAVVNAAEMVGTLAAQSIGEPATQMTLNTFHYAGVASKSVTGGVPRLKEIINVAVNIRTPALNVYLDPEYSRTEHDAHQIMRKLTYTRLRDITATVEIFYDPKLDSTDIEEDKDFVDAFFAIPDEDIRLELHSPWLLRLELDRGKVLEGGYEMSQIVDAIAETVGKDVFVIHSEDNADKLVIRIRVVAEKEDEELLGDEDMFLKRIEGTLLDQVELGGITGIIRVFISEGKKVVVSQNGEYDQEREWFLETDGINLKAVMAIDGVDAFRTYSNNCYEVYETLGIEAARNALYKELNGVIEMGGSYVNYRHLALLCDLMCSKGSLMSITRHGINRTDAGALSRAAFEETVEILLEAAAVGDIDDCRGVAENVLLGQMAPMGTGAFDVSLDMNMLKDVIVDHRLPVQNMMVTGIAGGMTPGGAMTPYDNLSPTWGDKGILGGAAFSPIQSSTNDEAGNFAYMGYGQSPMHGGMSPAGYSPSSPAGYSPTSPFAVTSPGYSPTSPFAGAGGASPWVGRGGYGATSPAYSPTSPQYSPTSPQFSPTSPSFSPTSPTYSPASPAYGGAGGNKASPYSPTSPAYSPTSPMGGITSPQYSPTSPRYSPTSPAFSPTSPSYSPTSPAAFQATSPRYSPTSPQFSPTSPSYSPASPAYSPTSPQYSPTSPAYSPTSPQYSPTSPAYGGAAPPQQNGQAQQPARPGWGGQGAGAGRGGYGTSPSWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYJ9</accession>
    <name>A0A1E3IYJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05576</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030408.1">
        <property type="nucleotide sequence ID" value="XM_019177657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYJ9"/>
    <dbReference type="GeneID" id="30194789"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN92781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="40937" checksum="F06446CC0F6169CA" modified="2017-01-18" version="1">MGGCMSSPSTDDPAADARSREIDKALREDEKRLAREVKLLLLGAGASGKSTILKQMRLIHDRSFETDEIEDYRKLTFSNIVGGMRAIIDVMDELNLAVQPSNRKYISLVDAEPPINTNEPFPSRYLPALQSLWQDPGVQACYSRGNEFALAENMPYFYQNLGRLFEPGYKPSNDDILRVRSKTTGITETRFPIHDVVFRLFDVGGQRSERRKWASCFENVTAILFLVALSDYNSCLIEDRESNGMQEALMLFDSICNSQWFIKSSIILFLNKSDLLAHRIQDPNQQLHEYFPKFEGKPYSFQDAVDFFKMMFRGLNRMASKEIYCHVTTAVDRQNVKVVMTACQDTILKNTLRDMAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZX4</accession>
    <name>A0A1E3IZX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030714.1">
        <property type="nucleotide sequence ID" value="XM_019177133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZX4"/>
    <dbReference type="GeneID" id="30194247"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10405" checksum="65018162AF48AB70" modified="2017-01-18" version="1">MLPPGNFFPTLIVFHLFALHMPITLSGLIDAPFGKFASHGSRLNINGNLGWAAMEIVSPVTFMVALYTHDHPPLNLSARLLQVSTPFRKREGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZY6</accession>
    <name>A0A1E3IZY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030718.1">
        <property type="nucleotide sequence ID" value="XM_019177137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZY6"/>
    <dbReference type="GeneID" id="30194251"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN94187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="175" mass="19337" checksum="04C6FAA8B8CFB829" modified="2017-01-18" version="1">MSLLRQSIARVALKPSILRSTPGLMLAQRRFASTEPMSASENIALLNSQRQYRPTSPHLDIYQPQLTWILSSLHRITGVAFSGALYLSAIAYLFNPMFPVIDSAHIVDLVHTFPGWVKGGLKFAVSLPFTFHCFNGLRHLNWDIGKGLTVKGVYQTGYAVLGATLASSLYLAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J070</accession>
    <name>A0A1E3J070_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030765.1">
        <property type="nucleotide sequence ID" value="XM_019177184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J070"/>
    <dbReference type="GeneID" id="30194301"/>
    <dbReference type="OrthoDB" id="2576580at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130056" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="185" mass="18785" checksum="EF611DD0417EDDC7" modified="2017-01-18" version="1">MRYAFLLLSSLASCALATLSITEPSAAHWWVGNSANTLAWDGKDPAEFSVFLANPDVNILTSMLALASIVPTYQTSLTMNPGDATPATGYTILVTNPLNSSDVYATSETFEIKKEGSSYPPQGVAVNASATAEGTGMQSGSGLASIASATSSSSSSSSQVGKGVVSYGALGLVAVSGLIAFTQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0C3</accession>
    <name>A0A1E3J0C3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030793.1">
        <property type="nucleotide sequence ID" value="XM_019177212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0C3"/>
    <dbReference type="GeneID" id="30194331"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="87"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="35323" checksum="3DE303C32A6A99FC" modified="2017-01-18" version="1">MRPSLIARQWAYHAGPSRFGKYPILLASSAMTSYPDPLPVPAHIPRPDYVPANFFTAPWGEHDMPDLDQDQAANGEKIEFGSEGEQAVRKVCKDAASILKKVSKIVKPGVTTSQLDEAIHKMIIERGAYPAPLGYSFFPRSCTTSVNNVIVHGIPDDRPLHPQDIINLDLTLFKDGYYGDTSATFVLPDTDKPGRDLVSATEEALDIGIRLCKPGVRYNEIGKAIEDFASRHGFSVNTQVSGHGIGKRFHQPPWIFHGRNTEPGKMETGDCFTIEPCLVQGSDSKGDMWDDGWTLASNTGARTAQFEHQVLVTPDGFEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0W0</accession>
    <name>A0A1E3J0W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030686.1">
        <property type="nucleotide sequence ID" value="XM_019177533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0W0"/>
    <dbReference type="GeneID" id="30194663"/>
    <dbReference type="OrthoDB" id="10435312at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22498" checksum="4926D9B8D17D686A" modified="2017-01-18" version="1">MPSQQPEDLEGASHQEEAYTHDYPLSEDTTFDYDSQEHWGTLGSLAEQGFYDFDAPMDVYFEVIQQASNQLHIFHGRPFSEAETAMHSIIQTVMESFLRRQREADRTEERQAGAEQQEEVTRQFGSMLEDPEQWWPEGHGAEETLQQLRESISDINLPDVAEETVISQALSYGQANDSGLNGLKMVVRSIANGTLGSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Y2</accession>
    <name>A0A1E3J1Y2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031138.1">
        <property type="nucleotide sequence ID" value="XM_019177106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Y2"/>
    <dbReference type="GeneID" id="30194220"/>
    <dbReference type="OrthoDB" id="2571862at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="242" mass="26613" checksum="D89CB083BC935ACE" modified="2017-01-18" version="1">MSHRNDVGCLGQDSAPHTPLPYDLSSYFAPRIEGTLQSAVSEGESDKSSPNHSKRPRDGDESDQEWTAHELGLVENMLLQPSSQFAPGSLPPSTVLDDFTTRLLHSQTTGSEKSRSPGEDSITTIWLHSWDSTRQKMNEIALENSRFGIEAERRKLPREERSERPGLRRMDSMDFLDEGTVADRSTSAVGRALRFANAFYQISPICGPETPFAPTAKGVGPSAVSRGSATIKSSPKGTQFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J277</accession>
    <name>A0A1E3J277_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030757.1">
        <property type="nucleotide sequence ID" value="XM_019177176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J277"/>
    <dbReference type="GeneID" id="30194293"/>
    <dbReference type="OrthoDB" id="2571685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130080" evidence="3">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="17251" checksum="CB4516F84AA45BC3" modified="2017-01-18" version="1">MPTSLLPTSTLGSILLSLFVQCPGAASAQPIGNNHGSHPQSKSRLYERDDDDGYTEQAQNWCNDNPSECKAVVSTLSMAGLFLILFLAFKWYRRRRSRQSKAKEALAESQAKEQKDQFEKQVEQKFFHRQREIKLRHEMEMLGLSEGTGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V3</accession>
    <name>A0A1E3J2V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030822.1">
        <property type="nucleotide sequence ID" value="XM_019177241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V3"/>
    <dbReference type="GeneID" id="30194360"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN94291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="216" mass="24039" checksum="1E7079F2A9852E47" modified="2017-01-18" version="1">MSKAQFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCIIDEEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRSSFEEVSTFHQQILRVKDKDYFPVVVVANKCDLEYERQVQPHEGRDLAKRFNAQCIETSAKQRVNVDEAFIAVVRAIRRYQKESGPPQASGAPSKAQSGGVGGRANEKDDHVDKGCCGGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J336</accession>
    <name>A0A1E3J336_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031248.1">
        <property type="nucleotide sequence ID" value="XM_019176773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J336"/>
    <dbReference type="GeneID" id="30193871"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000439">
        <property type="entry name" value="Short chain dehydrogenase/reductase (AFU_orthologue AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="35998" checksum="ED86A795A3A5F4FB" modified="2017-01-18" version="1">MANFDILHAKAVAVITGAASGIGLASALYYARKGLSIVLADYDQATLDQALEKVKGTEGVGTVLGFKVDVTSIKDIISLRDSVLDEFGEVHILMANAGTSAPTPAFSLHTPLEELQQDWDKVLSTNFRGVLNTCQAFAPFMAKAENASVILVTGSKQGITAPPGRAGYNVSKAAVKTYTEQLAHELRAEDSPCSAHLFIPGWTFTPLAGASPNATKPPGAWTAEQTVDYMVEKVFEKGDFYVVCPDNETSTSLDKARMQWSMEDVLLNRPALSRWHPSYKARFEDFIQQKQGLNASRSRSRGRRPELRDLSQAPSVSSIPSEADLLAFRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3B3</accession>
    <name>A0A1E3J3B3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031330.1">
        <property type="nucleotide sequence ID" value="XM_019176855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3B3"/>
    <dbReference type="GeneID" id="30193959"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="29009" checksum="87EAE9DE96F168F3" modified="2017-01-18" version="1">MDTEPEASAEPAPEGMEGEEGGDDERGFPTSTPPPPGAFVIPVQNPPSPSPPTPPLPDPDPYFNRDQCVPILPPRIPHLPPSHLATLKPKQMQASDFVDSGATARALAQLIPQALADTDTLGERASWNGGAARALVDIIARGVGQGLSGVGEAEGVHRTQHPASGPQPLLLPGAVACVLEDHMVAPIREPYRHASFFSPDRDTGRQVGKAERSGTGEKFDLQCQYQSPWNAFCVRGRRWIGYEGVEGIDLGSGYRKSLNSTIAAMGAISSALTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4D2</accession>
    <name>A0A1E3J4D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031384.1">
        <property type="nucleotide sequence ID" value="XM_019176456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4D2"/>
    <dbReference type="GeneID" id="30193550"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="356" mass="39668" checksum="FD757409089D92A2" modified="2017-01-18" version="1">MATNTLFAQQTGEIGGYNETMAAAAFESQALFLLKCQYASLVIETFLAGVLVMQLFTYFQYQKTDKLWTKAVVVWSAVWTMVITVYYWVYLSYLFVDNFGLWLPWLEVRWLAKMPLFDVLAVIPVQGFFAYRAYLLMNRNKILLGVLETLFGATASGPTLISKCLPVSPQLLLMISAWTAVTTGADVIIAGCILAGLLRSKTGWAHTDKLVSKLVRMTFEAQLPPTFLALAYCIEWSQTPSSLLGAVFQALQSPCYMIGLLFTLNSRIAFTTVDNDNRSQQTPQVFGMSNINNTRRPTDGIQVEVQTYVHDDQPYEYNHDKKGQSKADSLSDGDTERGVVFENGSRAHLTAGSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4L1</accession>
    <name>A0A1E3J4L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031449.1">
        <property type="nucleotide sequence ID" value="XM_019176521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4L1"/>
    <dbReference type="GeneID" id="30193615"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66921" checksum="FFFBF547289C72A3" modified="2017-01-18" version="1">MSALQPRPLAARAAAAPAPITTKIASTKFLAKRYMSAYLGRVALWTVLVLAGASVCVTGSASSGLYALIYAIPTFISLAVILKLRKSFITEPYRPAPRTSLVRLFLSCFWNPRAITLLAAYYVFGLTVSNAWLSLLGRNNWGFFTPTIRHPWQLNEHRVILVFSNACLLTTIAARDILGDKLKPTWPTERKPLGKAVQAALLSEVWTSTRIGFTFSWSVIAPFAYCWLGIRTFVWQWANWRILASTVRPFVGNFARQTSKTPSPWSLLGPMLVLNFVALVILQFPVKALMAYTTQSPLSQDQYLITALKSKDKYYLQFTLMELLRVAHIPASRKALFDNISRSPIPVLALWQDLLLHFGTVHHTLITRGSISRPLTPAQPSTPSSAHAIPIKQGDIFRPQPKAKSSSFNLKAAFDGPIRPSAPPPAVAENISKVGDLAKKRIGEAQGMALGRIEATGVGASFVGEARVARRDVHEWAGREWARRSVRVVLGDAVIVQRVIDIMVLLAGASIQEDTYGNVQQVLPSTLEAIVRFRDAVKLFELELVGKARVLGPAQESGLGEIKESLGEIVTYCEDSVRKVAADFGQSLGAFRFPPVIAHSLGEICKPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q9</accession>
    <name>A0A1E3J4Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein VTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031504.1">
        <property type="nucleotide sequence ID" value="XM_019176576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q9"/>
    <dbReference type="GeneID" id="30193670"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="62611" checksum="0DD81983B0A19149" modified="2017-01-18" version="1">MLHPAPPRRSLSARFASTKAVPAAPSRQGTNYKNRFSLTTTEQQKANMQTVNIPSDSVPENLKPIEQIVKRAKELKLAEPVISYWCCFSAAQKALKMANRSKEDTIFLMALIEALETMKVALATNEAITSEAAGAAYVENFALKVFMPTIRKFVVAGQFIEVLRCFEHGMTEEMEQKLLYARWKAADGAKALREGRVPTAGPPFPEQDHVSSPAAAAVTSPSHSSQLLQSPPQHTPGGGSRQNSFSNNARPPAPSPPTHTQIISPRPSPALKARNNPPPIDTDPRTPRSTTSTTGSGAWSTIATPGLPDDDESQLHFDLNRPDAMLPPLAHSYSGQGGKRSPLRTPIDEKKNVRFLGPDGAPLSPASTHLSVSSYTAPPAPPPTDIPSPEPQPKTLPVVGPPPSGRPRGDSSSSRNGVPHVHSSPNNDAQQAPSGGNGATSGSRQRTAQVPIPGSGSGSGSGQGSTRLPSSGNVPPPPPPSLIGGGAAPRPMVQPQSQGGGLGLSSPPPMQGSVTVPAISRGRSNSHSHAQPQSQPHTSSSSSQTFAPTPKTMSRKDIEYTQKHAKFAISAMEFDDFETARAELRKAINMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5F5</accession>
    <name>A0A1E3J5F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CND01770-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031540.1">
        <property type="nucleotide sequence ID" value="XM_019176612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5F5"/>
    <dbReference type="GeneID" id="30193707"/>
    <dbReference type="OrthoDB" id="2566743at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13777" checksum="BDF48014071CB65D" modified="2017-01-18" version="1">MYIPNFQGALAAGLALSGGFSGKVSSGKVLDYAVEKCIDADGNQRCSKPFPVTKSTCYEIKWTTDGKISHTTAEVRDAGSDEIIFYRDTDGEWTSEKNELVYLDFKPKVWGQGNSTVEYEVSQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6E5</accession>
    <name>A0A1E3J6E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031673.1">
        <property type="nucleotide sequence ID" value="XM_019176263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6E5"/>
    <dbReference type="GeneID" id="30193354"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="99"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="899" mass="99402" checksum="C07FA1A16563C9CA" modified="2017-01-18" version="1">MYNVNHSSYDSQHHPTDVPGTHLPKPLSSYYPPRSRSITPSYSPSPDGEQWPMPYVNSGSDAQLADLRYSVPMPEPRFSHTSNSGSSNAESTSNDYDSHARNPLVDLMESEKVYVDRLGLTIRRAAGAWSKKNFPPPKLDAMFRCIEACYRANKGFGQKLKDIGHNPSNPKALGDVLMRWIDDLEPAYLMYTSNFLTGFDTYPPVSANAALPGILEEMSASSKPVPPLDRWTLDALFVLPYTRLRYYRKLYTRLLRSTKEGRKDHGLLMAANDRLDKLAETVELRLEMDVSDKDGDAMSPQDQQQRELGSVISSARNDVFDALSLNEEMKDDQVRKSDEQVAVQSLHRPAAVRTTSVEYTAEMLATALSDLELRIDTERTIDLFSMQIKRCRLQMQPPTLPFERSLRSSHDVSIHFTPTATGRQIEHKRAHIFILSDLLLVAEWMDATVKAAKMQQIAKEQPERVGKGGPMPEMWLNYPPLAGKHLMVAEGNQANVLTVMVMRKETFVIHTESEIAKDRIMKDLIDCTDYALIHSTPGISRERAMASAALTSIPNAVGHTSFPSPFQSVASSSTSPCPDRVPLDVSIFANQLPSVSLRSEKEVEWPREHLYHPHSHSTGQGLTTMVALPPRGTSLPVPDQGLPEPLRQNYDQVRRPLVPSRPHIQTTASPQQPGPIPLSGNRDSVRSPSSRAATPQLSDQRAPASHSVISGLVATGAHLDQSNALLPQQHAVRHPSGPKRLVEPPSAVFQNNFPGRDSSTWVESSADDDTPPPSPEEEEPSTLAGPATVSAQMKCKVFIKQSHQQWKSLGPGKLRLYSQAKGNVKQLVVESDSASKQMLVSTIVLTDGVERVAKTGVAVEISNRGKRTGVVYMIQLRNEASAVGLFESLLVGSDRAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6G7</accession>
    <name>A0A1E3J6G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031705.1">
        <property type="nucleotide sequence ID" value="XM_019176295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6G7"/>
    <dbReference type="GeneID" id="30193386"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="60707" checksum="33124FAE21606EF0" modified="2017-01-18" version="1">MSAEKEADSSSSAPSTIDDHRQRLQDEIAAMTEEEYLAADKKLVAKCDRTLVPFMWYVAICYIPHVVLDEGLPAAYSQRDLLFTMSFLDRINIGTARLAGLNTDLGLTSLQYNTASMIFFVSYVAFEVPSNLVLKRFRPSRWIPLIMIVWSFFQIFMGFVTNYHQLLAMRFCLGVAESGLFPGISFFLAGWYKRREIAKRISLFFAGAVLAGAFGGIFGYALSRMDGIGGKAGWSWIFIIEGLMSFVVGIAAIFMVHDWPDRARFLTPLEREMVFLRLKDDVGIMQEGQFSWKVIRRAITDWKTICFMFMYIGCAEPIYSQSLFSPTIISSLGTYTTPQSLLLSTPPYVLTFITTMVTAYFSDRTGLRGFFLMFWSGIAAIGYLLFLTIPHTHPGALYFAVFLSTCAIGPCIAGVISWSAGTFGNHYKRATSMGFIFSLGNSGGIISSQVYRSQDTPRYLVGHGVTFGFTVICFISSVIMYFGLRRENRRREKLYGPPPAPGNHHEWDSEEGKTKWGLEGLSREEVVDLGDDHPAHRFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6I3</accession>
    <name>A0A1E3J6I3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031371.1">
        <property type="nucleotide sequence ID" value="XM_019176443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6I3"/>
    <dbReference type="GeneID" id="30193537"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="42618" checksum="8FE3B37AA1FE6D86" modified="2017-01-18" version="1">MPSPAGPPRRTSSPLSSPSSAGAPHPQQGSPATSSTLPLTDDESELTEEEGDPTEGEREQEERADEGDDAEEEQGGIRPSRAASQISSASLTPPPSDVPHKSPSPQPNGNGHPINGAIENDTSERLLDEGEEEDGDVTMRAAEDTVDEQEDASKANGHVEQVEVSDAAMDGQGADEPELNGYAEEDANMAGEGEEDPASGDHLESVPIPIVGYSKHLPHGPAPPAAAMKELLMLEVKFAELRNCLYLEQMEEAAAEEDMILNENYPALGYLYKTLEERRERLHEGASKRYEAQVAEYRRMKDAEKHLVWSSWTDERERIHWEEFQATWSKRRKLAREKGLVETHRPTKPIPPHSNNIRNFDWAQDAVPSPLPRDAAYQDVLAMVRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N9</accession>
    <name>A0A1E3J6N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031776.1">
        <property type="nucleotide sequence ID" value="XM_019176366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N9"/>
    <dbReference type="GeneID" id="30193458"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="47754" checksum="C4393D27D2249957" modified="2017-01-18" version="1">MRASLRSLALGPYASRTPHPAPAPPGLLAGKHIAIKENISYSQAPTSCSSQLLQGYIPPYNAACVDHLINAGAHIVGTTKMDEFGMGQVLTNYKHTTIVLTTGGSSGGSAAAVAEGSCWAALGTDTGGSVRLPASYCGVVGLKPSYGLVSRRGVVAYGDSLDCVGVLAKDIDIVEKVFNIISHPDDRDMTCAPSSVRSTSLPLDLSSTSLKNLRIGIPAQTLLPHPYTSIPPSLLTHLQSLGASLRPVSLPSVRKALPAYYVLASAEASSNLGRYGGGWYGSEAEKEAGRIEGESGQERRVRVRSDGFGKEVKKRILAGTHALSADEFNNTYLKALYLRRLLRQEYQRTFRIAHPLAAPYTPNSDGVDLILHPTAIRTAPLLNQDAKTGESVYLQDLITVPPSLAGLPAMSVPAGKAEDGWPVGMSVTGQWGMEGLVFGLGRAIEGWARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6R9</accession>
    <name>A0A1E3J6R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031806.1">
        <property type="nucleotide sequence ID" value="XM_019176396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6R9"/>
    <dbReference type="GeneID" id="30193488"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8610" checksum="CDB5BC329D349B4E" modified="2017-01-18" version="1">MSQPQSRYTQQNPNPLVDRSVKVPEVIQYICGDCGAQTAMQPSEFIRCKECGHRVMYKPRTTRSPIRGSLVIGPGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J718</accession>
    <name>A0A1E3J718_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031721.1">
        <property type="nucleotide sequence ID" value="XM_019176311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J718"/>
    <dbReference type="GeneID" id="30193402"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="268"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="636" mass="72028" checksum="6752D0481A2C13B2" modified="2017-01-18" version="1">MLHQEQPHRQRSRERHRHHHHHHRPRRSAELPVQSSRVEPALGHNASVTDEGLQAEGSMNVHVRVHDREAFWHEIDQIVTIPDSPSLEQLDNTLRMFINFCAAYHDKYLPGVVEIHHALAILLESELFVYYTERMVGIMMSDAQENTNPHDLYILYYLILFYGQRHPSLFRSHRRWKKLLPTLGEVVGLDIDEVSGTPSTVHRTDRPGLQSFILGLPPIEIRLRLPATYLMYEVARVQKLTPLELSTCDDQFIDHLFDLVETTRDQQDEHLNYAVIRLIVALNEQFMVASLPSNHGSEDAKKNNRVLVVLMRRLGSSKTFGENMIFMLNRAENTPDDLCMQLLILKMIYLLFTTPGTREYFFTNDLRVLLDVFIRELVDLPEECEALRHTYLRVLYPLLNHTQLRSDLYKRPQIKLVLKSLIANAHLKEIDPTTRRLVERCLEEPRKLERSYSAENVRTATRQDSAASIISLHAISTALPDGRSSTRAATQSSYPPLSVHPTKPTASTSIYTSRDPIRQSSLNDVSSSLSVSGRERPSSAASGYSSADPGATPPRRRRAPAPPAKKPERHDSSTSWTSFESDETGGMSDGSGMVMSPISAGEGDLVTEGRKGVPPPIIEVHPAPSQPPTGWITFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Y8</accession>
    <name>A0A1E3J8Y8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031919.1">
        <property type="nucleotide sequence ID" value="XM_019176006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Y8"/>
    <dbReference type="GeneID" id="30193093"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="12">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN97317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="43785" checksum="57D737FA40BD9102" modified="2017-01-18" version="1">MSAPEVFQLSLGPLTGVAFSPDRTQVAVSPNSNEVHIYEKKGSEWELKDVLAEHDKLITAISWAPNSNRIVTCSQDRNAYVWTPTAIGWKPALVLLRISRAATCVKWSPKEDKFAVGSGARTIAVCYFDQEDNWWVSKHVKKPLRSTVLSLDWHPNNVLLAAGTAESKAYVFSAYIKGLDAKPQPTVWGERLPFGTICGEFKSSDGGWVHNVAFSPSGDTLAFVAHDASISVVYPSSPGSPPSAHVVLRLPSLPFTVLTFTSESTLIAAGHDCQPMVFTGSPEGWAFSHSLDDPSSGGSRPLTPSGTGSRSGGVGRLGNNEAFNLFKAADSKGQRGPASPGAPTSAGLTLVGSDGLLTTVHQNTITWLDAYEWAANGDVAKVSTAGKDGRLVVWPVTAKGGAGGLAGRMGGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z2</accession>
    <name>A0A1E3J8Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031940.1">
        <property type="nucleotide sequence ID" value="XM_019176027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z2"/>
    <dbReference type="GeneID" id="30193114"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000014">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="195" mass="21643" checksum="7FF1C3E11CE0171A" modified="2017-01-18" version="1">MSRQLDNLNPTIFAPTTASTSSRRPPKTGKTNLWAPEAVIEDTLTEDWLGGEDRDIGSSGTESEGDEREEIDAEEVYDLLRSITDPEHPVSLEQLRVVNQEDIQVAGNRVLVFLTPTIPHCSMSTLIGLSLRVRLLRALPPRYRVDIRIKSGTHQSEHAVNKQLNDKERVQAALENKHLLSVVEGCLATAGKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9D7</accession>
    <name>A0A1E3J9D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_03848</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031887.1">
        <property type="nucleotide sequence ID" value="XM_019175974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193061"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000109">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="2139"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2850"/>
            <end position="3167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1143"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1060"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN97285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="3203" mass="357483" checksum="45ADBA6B9604B479" modified="2017-01-18" version="1">MATKVAQKRLQKEYLAMQKSPPPFVWASPEEKNILDWHFIIRGPPDTPYEGGEFHGLIWFPSDYPFKPPDVKFFTPSGRFEIGHKICMSMTSYHPSTWNAAWSVATILTGLLSFMLSNEITAGGVKTTDEEKRILARQSHAYNLKSKKFRYATPEMTDLPDMGVPPASCPTNTTISSTRTIMGILKRLEEALELYRSDKLKERSQGHDQLRDLLHNRDTILRFADAAQESSARPWISLFSCVMNAVHSEKVLMSKKDTAAQKQRLSNAISIVRLVAEQSVHHIGRLSLLALIGTMRQQLLWSRKIYEPALIDYSKAIVTLLSHPPHLEVLDRASWLSLMSISFAVILGDEVKCESDDDPDTLGVTLELKIVEEEERSGKRPSLLTKQIPVSNNNESFVKLVPILLSSGTAPIIPPSLNQGDILSANQRVGLGLLLKLRRFFVAQPHVTVYHPHLLRALNILLTELELNHRETFTKASIKILPQLVTLWSNSVRSQDRSVVDQVVIAIRTILPHMTHPAMEVKYVAEIRSSLEILWEVLPREAGSKRLEYLDMGCLRLKSRIQGRTNLVPFESVSFSAGYHFSVSQTFSWAALELYSDCCTYLYLTRSSDVEIGRNGSTPKRRKVEHTLSSLLSAVNLGKFESRLLALQTLIFLIGRQWSSLEMETQQAVFQCLHALLNDENEVLQSWAFLGLATAAVISTAGFDFHTDKTSDPTLNTHTSLRGNRKAPPSNDEIWNKVWSHAVRKCYVPATSRAASHLTVILIQLNLLDHNTIVGGIRSLLQSVEIEGPPASLDSVCVLHTIALEMAQSDIQLYSLGLEEKVLAWLEKIWAGDKAVRSEGSDGRLEQRTPSDLLGLLSAISGVQPYSLVEPTVDEFVPESAVSKHLFEEATTQSIRDFVLYQKFPQPPSTVTHMRAVTIGASESENSSPLECRCLRLSLLMSSMMRNDLVQEQGKSFIIHNHLAERTRRSIDLVVLVYAYQASLCLNGYTAHTASLQAATRLLGSLLPTMASHDLPLPDLDLIWRGLRCLVADTGKDYDVDRWPILVMPGTPSGIRTDLLPQQQGPPASRDSGGSPTATSTQYHSTFPSNFPSTYMTQEGSYPVLPQDSTGDALVHAIWRLPTVTTTLKGLFEPCLQIARRSRSSDPVNSQLRAAGGHDSDDDDDFSGMSVEDAAVLPSKETPEKRASASILHSVVCFRLKGGKLAQNASRAYKDPSLINCFLQSDAPHSFAVGLALCEAIHKGWLRINLEAVQLVVDELNGLIGSYSYRYDEGAWSFAFAFLRCSASAWLLKADTKLFEACMKLIHFVAARVLHGTPISWRLKYDLLQFLEDFTSYEKATQLWAIYPTEDTRNEEIAEKNPKINELWVLAARALRDDDIRIRVRASTMAGNAFYRPILGLSQHPEFYQSCSRQSQDEARIDHFVTDILWNVNCCVASAAVRQTAVLMLCNLAIDTSVGLPYIQAGLSAAAGRLGLSSASTLCLPYCAGALVAQAYTNTANSLSHILGFSDRNALHVACLKACGPYLLYQEQFNFYSRACESIHLPTEEVIRQNFPEIASVIMTLSWSVNQRDKNIKSGLVRLAALPGIDTVETAKELLEDHVDAVRAHVWELIDLNTTPEHIISLLKREKIESATFREIQPPDMESSPGSLASTALQPSASVDVVYDVSSSLATRHGTSSSINEMVFAAVLRLTFLINEAFLVSEQDRHLRALFCLIAVNAKAFRQKMILGTFLHEVLALLNQPNLSHTVFPMVKWGFTRLTTLAGTGPTNTTNLFLQLGRVWSVSHRAASVPRQQYLAHLLENWITSVLPGWETSTVKDSFLQAAALWPDDVRSRLDTPLKSPTLWELRDLSEANIVGTGSELCKQFKKLAEDDYTGKVAPAFMASAFWTIKSDMGREWDPEDISAFQELLYMAGGEIHSAPPIGASPRQSTANGAHDVFLGISDFTVRLLDDHHHGVRAAAYRTLQGMKPHVSAAGIKTRLSPVEHNLYEILKPLVLAQSQKEYRLSDILDKSSWDSLLWNTEEWALDLARLLCNVASRQDPFYLSINPLLSSQVPLRHLLPYLVHAVLICDMSNKASPKNSQILARYFEQVVQSSQASTETIQAVIDISLYLRQYQAPHASGKEDNEWLGIDLVTLSQAAIRCDSYVTALLFLELARDQRVPPDLTRSNIQRIMYDVYSNVDEPDGFYGIQNNDARDALSRRLKHEGSSWAALAWDGAIFNAASDGPSNILPVVRNLHDIGFSRLASSVVSQAEHATGAATEDPFFAELGWRTGNWTLPLSTEAKATPSGLLYEALSAVHKSRDLDTARVAINEAVQISIEELSKASREKMSSIESITTNLLCLRELQEWNRQQSEDSPNSTVYRAGENFEDSGTRFEFSIAEKIIAVRMSLIHSTKHRESQYLIGDMESPGLKATVEAEKACHLQLCKLALKDGRMQTAINSITAAQRLEDTSRGSEETQDLFCEVLWKQGEHGLAIQLVETRIKEEKGSSRDLNGVVSLRDKLALWTSSARLRSAEEIKSTFEDAVSRVKKFQLRKSEHARLYYHFACFSHQQHISLANTSEFKRLEEREKRRQAGAIASQALGKGGRRQSKLQKGEIHLAKFAEFKEAQADSTAFEDLKQRSAAYLRSAQTNYIKALCYSNEFDDTIMSLVTLWFENDQDQEANQALGQQISTVPSYKFIFLAPQITARLNQNDDKEEFAKSLHHVVLRVCHDHPYHILYQVITLAHAPSVNKADHGDPGSDEAAAGRAAAASNILEKLSSLDGKSLSSAAAKSMQQFVDIAVDWTLEPIIHDEDAEGVKKRSGSLEEDSILNKTPQNIPIATKPPPIDCTCKYDNIALFSRYQNTFTIAGGISTPKVMTCYDNKGHKHTQLFKRDDGFRQDTVMEQVFERVNHLLQERTQSKRRHLRFRTYTVVAFPLNTGVIDFVPNTMPIGDWLRRAHTKYRPHDITASNFSKRLAEPRSPKQPKLDKSVLTTKLVEIFKTCKKSFRPVMRHFFTEKHRDPVAWLSMRTSYGRSVAVTSMTGWVLGIGDRHCSNILIDNITGELVHIDFGVAFEAGTLLPIAEHVPFRLTDDLVDALGITGVEGVMRRCSQLALQVLIDSSDVILTILEVFKHDPLHSWSSAEKQVRAQGGGHDVLLAHEKSDRVLGKVREKLSKELSVEYRVNQLIQEARDVNNLATIYTGKSEVLSCVLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBL0</accession>
    <name>A0A1E3JBL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032099.1">
        <property type="nucleotide sequence ID" value="XM_019175609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBL0"/>
    <dbReference type="GeneID" id="30192692"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="595" mass="62930" checksum="125B4DB03D2769CA" modified="2017-01-18" version="1">MSVARIPPPPSFSLYHLASSASPPSPLPPLTPPAPDIPISSHYSLMSGQDIATNGLGERNAGYTYRQTPSLSSERSTVSPSQIASQGQQQFWKTQLTKQYSPTLPQIQSPAGAPPIHSPTHHPHAMMLPPLRLTTQDPRPDPRLDHRLDPRLSATAPLEPGTPRPHASPISQGPGMGYYPYPMSYPPHRYYPPHQVHGHPGMPPNSASSAGTPEIFTPVSGHSDYSFYPPPQQQQMQATIQPSVFSPWQAQQQHAQSGGQDRRGPPGTLSFNISSSSEDRVRESPGSSANGTGGGGDGRWENKSPMRENGRGSPASSEDEVPRQITYTTDAEIKQCATIKRECFNCTSRNPPSWRKSLCNKCGIFERTHHRPRPPQNDDQKLRKASEIPNPLFGGANAGGYGGGRNGRAAPPPALQTMSMSSGSGSPRSPFSGTQSTPMSASFTYPPMYTPAPQSSSSEYPPSSSYLRRPASTQPQLPNLSIPSPPFASPIISNDTTSAGGGGGESGANRYYGHTHSASSPYAHAYASRRGYAPPSRGSISSTSISGGGAGSVLGSPIGSYASPISGPGQVQGQGGDGWHSRRLSGGGTEGGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIC5</accession>
    <name>A0A1E3JIC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MEMO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032841.1">
        <property type="nucleotide sequence ID" value="XM_019175109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIC5"/>
    <dbReference type="GeneID" id="30192184"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37640" checksum="A2754D1C25763F7B" modified="2017-01-18" version="1">MSGIREATHAGSWYTASSTGLSQQLNQSLSAVHPLPELAYDPPVQDAKAIIAPHAGFSYSGPAAAWAYKSIPVDKITRVILLGPSHHAYLPGVALSKFEAYETPLGDIPLDLKAIHDLRKTGIFSDMKSSVDEDEHSLEMHLPYIRLIFQDRDISLVPILVGHPSASTSSNLSAALEPYWSDPSTFFVISSDFCHWGSRFSCTPYYPDPPAIADPVPPTSASDRPLAQSRKVDLVKKFSSATANPDVPIWRSIEYMDHEGMAILRNPAKQGAVDEWHDYLERTKNTICGRSPITVLLNLVQHVYADRAGKPEFTFVRYEQSSRCVTGKDSSVSYVSGILRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JID2</accession>
    <name>A0A1E3JID2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="1">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032790.1">
        <property type="nucleotide sequence ID" value="XM_019175058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JID2"/>
    <dbReference type="GeneID" id="30192131"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF3h C-terminal" evidence="3">
        <location>
            <begin position="190"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="40278" checksum="37404739A7F415A7" modified="2017-01-18" version="1">MAAALAASLPSAVSRQSTPLPQKEAASKVPLKLEGAVDAEALREVESVQLNSLVFLKIMKHSTDILPAPPASVLQQDRNPPPSTELSSHVDALGVLTGLDLDGVMEVEDSFALPGGETSLGPNSYSSKLLSRLSTVSTPDSPIGIYLSTHNGGFATRVSIDLLSAVEKSAGRGKAILLIHDASRSNGNDLSLKAYTLSEGAREAAKKGKWDGQTLQEYGITSATLLVPLPVKVASSALLDAFISTLSTPAPSASAPSLSSPSTPLPPSFSPLLNPLSTSLTSYLQNTLDALTLHSHETNNIAFLSRQIAREKSKHEQVVKDREEENARRRKAGLSEFPEIGEEVRGGTKEPSRLEMVCLGGTVEGVAKGMAAEAGKGLVRAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKV4</accession>
    <name>A0A1E3JKV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03074</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032939.1">
        <property type="nucleotide sequence ID" value="XM_019175207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192287"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05696">
        <property type="entry name" value="S1_Rrp5_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000727">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000289">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000340">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.162, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="238"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="330"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="425"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="516"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="605"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="691"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="797"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="891"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1060"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1472" mass="161303" checksum="6D8876488A11A8DC" modified="2017-01-18" version="1">MAPTKGDHQEPAAARPAPAFTSSLQAEEADFPRGGGSSLTAFEFKQVREEGRKEAEEEAKAQASKGEKRKRQVSERQTKRLKKNEDAKKREERDKEGIRVELLNYKRLATGTRVLARVHTILPLHLILSLPNNLLAHVPITEVSNTLTQLLRAEEDAAMEDEEEDESDDESSAPDLAQLFVPGQYVPAKVLTLYPTASQSFVSQYPVTETTRLAARVELTLIPEKVNSEVAKKDLEKGYLLTGEVKSEEDKGWTVAIGLDTEDGGSSVEGFVSKDDAKKSNKTLIPGQLVPSTISSIAAGGRLVQLTLNPTELVRSQVSEVSTVGSLVPGHLVTALITAVVPSGLNVKVAGFFDGTLDFAHLPLGEDDVEEKYKIGKKIRARIIYDNLSADPRSFSLSALPHVVDLTSPTQEGDSTPLELAIPIGKIYQSTKVTRVLNDWGVMVRTQDGLEGFVHISHLADERIPVLSKAVPQFKPGTLHRARVIGHSPLDGVLLLSFEQSVLSQTFMQVTELKIGQQLKGVIRKLTDTMLFVNIHGNVDGIVQPNHYADIKLKHPAKRFRPDASVKARVWSVDPIRNRVVLTLKKTFIESDATIPQSFEDFKVGLVTLGSVLKIVDKGIVVELFGGLKAFMPHSECSQTFVKNLNEAFHVGKPLSIRVIEADPETARLVVSAKQASASAPATAAEKLEVGEAVTGVVSQVHAEQVVVKLDGSGLTALLSLSNLSNQKRMGIEELRESLKAGDKIEDLVIVSKNPVSGLIIVNIKKTPSAKKTKTKEEKAASGISANVKAIDSIELGQILEGTVSDHTPNGWMVKISHSIRGRVHPCDAADDLSLVTAQKPLSVGKHVKCYVLKVDASKRAIDLSTRPSRVEGKEDVVDKEISTVGDLKEGSTVRGLVKNIAGSGVFVSLGRNVTARIMIKELFDEYVKDWQSRFEVGQLVSGKIVSINSNTNSIELSLRKSPTRAAKKTALLSLSDFTEGQKVVASVKKVEAYGMFLKIDGSNVSGLCHKSEITDNKKADVAQALKGFREGDQVKAKITSIDIEKNKISFGIKASYFGEDFEGGEDDEEEEEADNDVEMESGDELQLDQDESEAGEDDEDEEEDSEAEAQDDAEDDDDEEEDDDDEELQPEASTSAPKTALNVASFDWTGDAPEAGPSDSESDSDDETSAPTKGKGKNVDLTATAPSDRPSSTAEYERALLASPNSSFLWIQYMSFYLQLHEIEKARKIGRQALEKISYREEEEKLNVWMALINLEIGFGTMSSAEKLFEEASQYNDKRTVFMRYADALQAAGKEDAVEEVFKKIVKKFSAYPESWTRFAEFYLLKGDADGARALLPRSLKSLDKSKHVETIEKMALLEFKHGDAERAKTLFEGLVDRLPKRLDLWGVYIDQLGKGGDIQGVRGLFDRALNQKLTSKKAKFLFKKWLSLESRIGDAPGQEKAKLRAKEWVEANSKPVTGGDEESGSDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMK7</accession>
    <name>A0A1E3JMK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02826</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033347.1">
        <property type="nucleotide sequence ID" value="XM_019174968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMK7"/>
    <dbReference type="GeneID" id="30192039"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="256"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="148"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO02095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="577" mass="61983" checksum="1DB6127E350348FF" modified="2017-01-18" version="1">MPSSVVVISDDESDEEVSVVAVRPSRSTSSSSFPSVQQTASSATIGRKDTITILSDSEDGIETDNDDAEQDVFKLIADVAKLSPVKSRANILSSRASNGVERTSSASILDTVSGNGIGVSGRAKGKGRALEGTRSMIEGMSTIDRLDSMEDPYLSSPVAPRVATKRPPAADTAGAKKKTRPSGQNSEGLSKEQLAAIKASAREAKAAQDAKNKEAKQLAKDTAKASQAEKSLGKKMKDANKLRVSKNDTVREVALYLSADMAKPSSPIAGALPEITTKLKDNQSDLRFMSDSDSPIPGAIRFKRHLKSRWDVAVKRFIPLDQPRWVWEKTVLILITAEELVDKIADGDDALVQWASDVRLLMSLSQQNQVIIMIKGIEKYYSKSKSMANKDYMSAARAGLEGGAVGGAMTAGRRAVRPTRDIIEEEMVKLQVAEGCFLVHVEKTEDMEDWVFNIAADVAIRPYKLISKSHLAFSPQDGQKKALESTAVLELMLQEVQGVTTSAAAGIAAEYPTFRDLMEAFEEAEEGPRGKSGAEAMLANCKVATLVSGKASNKTVNKTVSKRVQNVLRSTNGSGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JML5</accession>
    <name>A0A1E3JML5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033148.1">
        <property type="nucleotide sequence ID" value="XM_019174769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JML5"/>
    <dbReference type="GeneID" id="30191838"/>
    <dbReference type="OrthoDB" id="10531085at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="26285" checksum="01F4DA3779346F65" modified="2017-01-18" version="1">MLESLSSRLSSKLGKSSKHIPTYRHISATTDDITLEFPAEIEYRVDTLPTGTLLPKPTSRTANLPQTAMSKQKSGWMAESGQNWYLGNFSVRAGSIGACGTVSALGTQSELANYPIPSGDLREGHFSGPFTTKQAFGGQVTTKASDPNSFHRTERDFFKHLEEESGNVYRLVNVEMGDYCEDIDPGDQGTLVNTRDVSEIGDRKTATVTKRYSKARWNFRAQLRVPTEGNLPDKKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR68</accession>
    <name>A0A1E3JR68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033396.1">
        <property type="nucleotide sequence ID" value="XM_019174344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR68"/>
    <dbReference type="GeneID" id="30191403"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000039">
        <property type="entry name" value="Integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000029">
        <property type="entry name" value="Integral to membrane protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30389" checksum="8F98C1E0B29A8E7A" modified="2017-01-18" version="1">MKENKAAENALGTIGAVFWMVQIAPQIVKSHREKTTKGLSASLMFIWGLASLFLGSYNVVQELSIPLQVQPQAFGVLAAISWCQCLHYERGYSKKSVWAIFIVFCCIFAGFEAGSVFALRAGLRNGTEWPITMYGYITAVLLAVALLPQYWEIYRFREVIGISLMFMAVDILGGIFSFASLFFRTDLDVAAFVSYVLVVILDGIVVLLYFILNPIARRRRRAEGTEGERVGDPEAGWGSTSANSTEPTLVGHGMVVDTDVEKEQEGQPREPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRJ1</accession>
    <name>A0A1E3JRJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Septation protein imp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033550.1">
        <property type="nucleotide sequence ID" value="XM_019174498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRJ1"/>
    <dbReference type="GeneID" id="30191559"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="42"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO03499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1092" mass="117925" checksum="AC09DF9FE9077C1A" modified="2017-01-18" version="1">MAQPPEPRRSQSSTSLYKMYHGPNGGMNGQQVGEEELQNPRLFFCNSFWGPGERGYDVIMARLRGAGRTVEELRAFWKERSAIEEDYAKRLNKLSRTSLGRDEVGDLADSLKHLLAETAQQASYHSSLGNEIKQTVEHPTSELSVRMNNLKKGLQAAIEKSYRSKGLQEGHVQKARERYEQDCLKINSYTAQSSLTQGKELDKLLYKLERVKGTIGANEHDFLQFVKVLEGTSSKWEQEWKNFCDHVQDIEEDRLSVSKDLMWVYANAVSQVCVEDDSSCERIREKLEQFEPANDIINFVKGWGTGDLIPDTPRFINYSAGESYPIQPAYHVANFMRISAKPPMTLTPGEEIQEPAAEPEPEPEAIPEPEAEPETAFNANGLSDGMKRTTLRDEPVKTPVAEPGKPATKPPFGGVALPGMSSATSPAQEKGPSYGSMPPPPVPSTLSMPEPRVPSRQSQGPPSPRRDINDEQDPMAKALAELRRDPPPPSSVRRAPSHKRADSVVSAAGSARGSAYGGGIKSPASPGPGRHSYHQGSVPAQSRSPPIDSSLSPPPGGHTAAALARSMDEFKHHSAQSNRNSVNYSNFADDIVGSHPTSRPTTPVMSPITGRGPSPAMMQAPKQPATHIADEVLSQYHQAFPGEREQSRSRAGSVMSNRSRSSFIEPPQQAPPSPSAQPRQGFVGIGAGGAARSPSPQPSSFRSPSPSPAISPGALGPQNLGISLNAKGGVAQDTMAEQYRRQYQQQQQQQNQPPPSAPGPQMGSYLGQGSSQYGASAGRGPSPAPSSQPGYGQRGSVYSAPKSPVAASPIVGPPAVSNRPISNYGQSQQQQYDQNAVPSPHSPYAPASQPAYGQYASSTQAPYTQQAPAPEPNYSQRPNSGYNQGAAYGRGPSPQPQQQPMYAQNQGYQGQQYARGVSPAPGAQSQQYQRGVSPAPGAQAQQYQRGVSPAPAQAQQYARGVSPAPGAQQYGRGVSPVPGVQSYGYDQHQQGYGQPRRSPSPVPNQPPANATPTGQWSTTGLPVLFYVKALYTYEAKSSAEFDFQEGDIIAVTSTPEDGWWSGELLDEARRIAGRTDFPSNLYVFFNPFCTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRQ2</accession>
    <name>A0A1E3JRQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033595.1">
        <property type="nucleotide sequence ID" value="XM_019174543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRQ2"/>
    <dbReference type="GeneID" id="30191605"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="12">
        <location>
            <begin position="403"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO03544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="716" mass="80958" checksum="469DA68A3D8C63BF" modified="2017-01-18" version="1">MAELAPPEPEPRLSTSSTSSAHSLDLPSLQPLSHTHPLLSAPDFDPDAFLLSRIHIPLEELRGELREYLGQLREELVQLINEDYEEFLSLGTGLRGEEERLRMLSGPLLSVRSEVESVRDVLAEHQQKVQSKLDERASLRSEKALLDLLQRLFDTLSRAEALLDQPHHDEEGKGKLVGRVASEYTQVVYLLNKAKAEGCAIVDVVQERISKIKKRISDDLSTVLVTELQNQDKAGLKHCLRIYELIEGWEEAEEVIRKDFQVYCRDAISTQALNPPTTPTVPLTPHPLQNSLTSLRLPPKFSSPLALLYNQLLTRVAIYQPLMDVGEEVSSKFDFFARVIWPEIGERIMEKLGGVIFAAGRPDELHRHLTTTYKFLELLESIAPSLRSVKTMRQSQTYLTFERRWQLPVYFQLRWKEIVSGVEQALTGQPSYTSKEKESEWALGQSEKVWKGVESCWREDIYVAELAPRFWRLTLQIVSRYGTYLKSTLDSYVITEENTSQEDTALRFAAAAIIDLEQIGARVRELQVVKELDLADHLKPSTSLYISKIESILIRRCLDPLKLIRSIASQFRASTPNPTAPSQASYYVPSVMKPLRAVYGQRPELKERHSEELGGRVVDEVLKNFASTLASVKKTEDLLRKHRKSKKTTGFSSFFGGGAAAEEGKGEEGEKEEERFAAQMKVDIKALREDAESLGVEVEGMESWKELVGVCEGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRY7</accession>
    <name>A0A1E3JRY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033487.1">
        <property type="nucleotide sequence ID" value="XM_019174435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRY7"/>
    <dbReference type="GeneID" id="30191496"/>
    <dbReference type="OrthoDB" id="2571241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="261" mass="28101" checksum="3FC9BD482621097C" modified="2017-01-18" version="1">MSYVPQDLDLSESRYTPVDLSLPQPSLSPPPAAPSTSFTTNPQTHTDAKPGRRRVSPFSPWYTSSEGSCEPPSEHLSHCTGAKPVFNWQGGKLVALPLSPSPPPPSLSGFGSLAPKSRGEYQDTFASNSRFTRSQVNKKRSSAHIGKTTSSPTKPKSKPKSNPKLRPKASGGGWRNVGMACDKCKSRKSRCLGGKPVCERCQKSGLVCEWTVNPRSRNSRSALNSQAEAAAAAHTSQQESTGVGYKSDKSEMEVDDDDMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG8</accession>
    <name>A0A1E3JWG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033741.1">
        <property type="nucleotide sequence ID" value="XM_019173934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWG8"/>
    <dbReference type="GeneID" id="30190986"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54422" checksum="3E88262E5A11C492" modified="2017-01-18" version="1">MASAEEKKTQKKKEEEEMKAKRKEYMSKADPSTVEKMLGGGDLGKDYFKEGEWKPSWTYLEFDGDACLADVLGKPQEGFYAPAGTMLPLGAQLPEMTVLKYGGYIPEGTSFPGGVMVPMHARMVNVTASEGNHQAISKVSIRVALLIALRERLRLARTNAGYSASTTMAAVYPSSASAPSDVFLARRIAEIQTHFPQLYAQVAAAHTTEPVQILRDRPWKNSEVIRKGVYLPQQTKDKEFAAVLHLDGQKMMQEDFDNAPLWQITVYASTSQCRVYVALSVEHVMIDGRAMANLFQALLAENISDLPQDTLEATPRAEDTINMRPFLQTYFAPAKSWPAEQIDVSPLASPSALPLFSLSSGDVSQPKALARLHKVPALNAALLAMYGLAVWSKYRYTLRPFRLVAISARSERDAPLCHAYALSNYVSSHQIDVYIQSGDDFWTIARKVSYDTSNPRAISLARMRMGMIAQIPDGIYISTFADRHFLKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWJ6</accession>
    <name>A0A1E3JWJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033825.1">
        <property type="nucleotide sequence ID" value="XM_019174018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWJ6"/>
    <dbReference type="GeneID" id="30191071"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130621" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="154"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="23606" checksum="B085F04D89F350B4" modified="2017-01-18" version="1">MSAFTLFIAALPLLATLGRATPLPAWEGCLSIDNAPSDATPIPAISAVNCATQCWNHIDNAHYAYWDWSAEAQCLCSASGPNMNNFEMINADQAFGTCAEGIAVYARPAATFKVQNEKKREDKMDRLRKARATVESLCPEPLLACAVAGDSSSYECVDPNFDLYSCGGCINGAFSSSKLSSSSALDCSTLTGVTSNACVWGQCKAFRCESGYTLKSGSCVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWS0</accession>
    <name>A0A1E3JWS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01996</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033959.1">
        <property type="nucleotide sequence ID" value="XM_019174152.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191209"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12303">
        <property type="entry name" value="RRM_spSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="1445"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="15">
        <location>
            <begin position="1571"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="806"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="889"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1246"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="148"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1144"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1272"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO05304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1587" mass="173770" checksum="C20BEF1E80606645" modified="2017-01-18" version="1">MAHRNHHHSSSSSANPDKYTTLDSQSRSRRDSLPQSSSSSQNGMLGRTESEKISIAFPSSSREKRSDHNARKSKAGDPESLASRLGALPSSSRNGRSPSRDSQRRFEERGTRDTEHGGSRRSASFKDSRSDGRRGSVNSTYGYSESGASRDYRENRDRDRRHESSSYREDDRMRDRRYSRESDRDRGQRVEFGDRGQYRSSDRHGERHRYGERGWGKDNRREKEDERRPRERDARERDSERGDESRGSGRERSRRDSVHKERAHERGDGPPQGDRGRSEEQGRGGDEEKPRDQQRDQSKDRRDSRGWGQSSRHGESDREASPSKERRASQSHKPPSPPSNRWVARQKAEDPSTDKIKATGLLANEESRPKIHIPLTGNASSQPIKIIRPPPFHIEAKLSLPRPPSPGQRPPTPPRPPSSPPATPKPSIPLAGAPPTHPKTLVRPVRPIPSGPATFSGLPNHWRTTSLSSSTQSRPVTPPLPLVPSVAAPLPPPPAGFVPPPAAPVAAASVAPSLTGQEGAPPPPSEAAPPVPEKSPSPPPPPIKIPFQSSTLSGLTSLSRANNPEKKANGGSEMPPSFHFRPLPEPAFPKETSSEASSPAPEVPAPRPAALAERAPEAPWVCPPYVAPACVKHRPGKGNFLVFKGADGKEQKRLDGMIDGKVVEVVDPRKDLSKEQLARGRGSAKQRDEFHEWDSNSTGPAPPPPPAAVLITGLNPLTTVDQITKYLRPHGRIKELDSKVNPKTGMQLGMCWVKFDSPPSGKPGTANDVANSVVKMCDGKRISNNGNEKIKVVLDGRGLRTAKAVKEEMERLYPPKKAVDKPLEEKKPTPTPATAPASTPTPSSQVASTPARLTSANGVGTVGNHTPVACPGPTTALNGKTIYTKPLGQGFQGGFQAQRFGPNAPSNNRFSNNQSQNRPFGHANLRHLGPYAPGGAKNPLPRPLQQPVQHLESSFTSAPFEKHGASADRGRALNGRSSRNRSLSLTSSESDSDDDRRPGRRGLSPYGQRRVSKSGPSPEDEERLAKIREQIKENGKPYIFVNSQGLPTTASYEGFLGDHFKLFKPAKILRAHLGWYILFPKDNAAAQAKRVLDGTLVQGRSINLAVQTSGPRVTQPLTAPADAPDRMSALASAPTGDPTWKKMTIAKKNRPAVRKVEKERLKPVKKLRPVDSSSSEDEEAPTSVAALKSKVKRDVNYSSDSSTSEDDTPKTRGKLSTKSVVKVKKESEPIVEDIPIGDVTSADAIKHSAKSQKLRIDSEDEDDTPLSTKVASNKKRPAPAKGKKANKKARIEPDGAESMDVDMPPPPPKKKKPTKTEVDKFISSGALEDEEDAYWLGQVLAAQEEGLEPVFSDDEEIGVEEDHPLYHRSGSWRAEGWKKIPQVQKSRYLPQRNRAAVASEDNSVTTGRTARLAGRDQHRQTAAVAANQTVESDLFAFNQLRIRKKQLRFARSAIEGYGLYAMETIHVGEMVCEYVGDLVRATVADVREQVYLKQGIGSSYLFRIDNDIVCDATFKGSVSRLINHSCDPSANAKIIKVNGQSKIVIYAERTLYPGEEILYDYKFPLEDDPALRVPCLCGAATCRGWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWV1</accession>
    <name>A0A1E3JWV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033928.1">
        <property type="nucleotide sequence ID" value="XM_019174121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWV1"/>
    <dbReference type="GeneID" id="30191178"/>
    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="605"/>
        </location>
    </feature>
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            <end position="740"/>
        </location>
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        <location>
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            <end position="764"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122038" checksum="3CFB24A43151CB73" modified="2017-01-18" version="1">MVDNPQVTPPEIRQSIYRKAVVELHNKIGVDYVDWMEDTAASVFETFTEIDTTTYPETFGPRDEDPLVHFNEWLANLPRPAYDPYSHYESRAEEEGANGRMKDPFINAVMKRHKEAKSSSPAQVSFKPIGEYLCTVLTLSVTTSDDPWPEYLHPREVLMTAKMMEETLTIGNGDDGLPENYEVLGDKGFHILGILRNPQIKPRQANAEEVLNLRPDWSDEELHIASEKVKDVNTKIKAYNKTISGAVSGNPIWGKWEEESELLLNSVPLPLSPPLFPLKEAVADLPQLPETFKDLEGTVGEASHSRLRLSGSRAMTGRGLGPRWATDNDSQEFLEQVMSSNNLDKFDGVPFAPLTPKSVDKHSRLQPIQSQATFLPPSPPPTHSRNKRMPWEENPRIEPPLMPARFDLPSSNSHHIDQLFTPVRNSSPPLPPVTVEGRTDIATPSLSGVAEQMEDSCVQPINKVLRDILSTTQLDTHKEREGYGTAEETAFAHATSEELDTTKTNHIGIPNITEEAYSDPRNNLPMSYSGLADSLAGGVETDRMLFVKYPGVSTALASELDWDPYRSHHHSPVRHDHAANVSALPDPPASQLRHSSGHLPGPVHHPADAAIRSLVERPMKKMTPVKPRWMTIQDAEREEALKSSNKKSLTSSALSETTTLPATYTPSPAAKGKTNKRKKGQVIPGDVGDMPEDDGLVDAEIVTITPTPKSTKEAVGDSRKKRKAAESLKAPSNPTLDDILMSIVPPPQTQESNRERTGHSKELSTVTLTRPTNADPSTLSGFLHLQNLGHLAGQDAEVACKQAVGQDLSAIFEEDEEGEPVNWRADPAIQNPSWYDRASQGNVQPYANPMPVIAKVDLFKNRPLIKALESQNFYLFDNRDLQGADLVISPVTAVIFRSLQTLPDVHVQLLEQLKEAASFYHHVILVFETISFVIADKHEDAGKCANPLGVEIIHALGSLKRGQKAAWQGDADIIGKVEFVFACEGANEVVRGVMGALESDEAMLKDRMGEEEYQRYGGRRWMQSEPVPDHEATLIDTFGVNTFNARFATVRHGGAERLAYDMSAEERLLLLGPVWGEDVVIRFNDVLKSTRSDEGGEMAGQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWZ1</accession>
    <name>A0A1E3JWZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034033.1">
        <property type="nucleotide sequence ID" value="XM_019174226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWZ1"/>
    <dbReference type="GeneID" id="30191284"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="31991" checksum="76AAE32457CB5752" modified="2017-01-18" version="1">MSDPAAALEPFLILVRSTKGAAAAKIILDATAAPGVYVFGELLDAPNVQHVSGTPSYKGHIELLRLFAYGTLSDYEKNKSSFPELKEAHIHKLKQLTLVSLALHHRSLSYDHISSALQLESIRQVEDTVIDTIYAGLLTGKLHHDQKVLHIDSVSGRDVRPEDLEQLQQGLANWCQTAQTLLSALDNQINTLRTASSDEASHNFAYKIHRNEAYRNVQAELAHEKASGGFAGAASREKILGGFGSGRGGEHGWEGLGGGERLGGMQDGGVSGFLSNLQNVGNLGGAFTSGRKWVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYZ8</accession>
    <name>A0A1E3JYZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase SKI2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034092.1">
        <property type="nucleotide sequence ID" value="XM_019174285.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191343"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="312"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="606"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1288" mass="142721" checksum="04B3A0AD7B5751E3" modified="2017-01-18" version="1">MALQDGAADEHALFLELLKTAANPSAPDAIPTDDLAASLGIDGPLSKQQALEILEKEVLAPVKGIEGSDLGRWQVQPPIDLPLPPLTLSPLYQTHSVAPSFRGIDGEFTNWREALMPKPPAHPSLSSSTTRAPGSLQNFVRGKGSYAPFLPGGLETAARVEEEEEESEEEEDGVFKSRAPGLKRGVKLDGAEEFLIEMLGQQQITAKAKRRRRDGEFEPQLAVSRLGDKDRDIDGIESSAQVKASDKNIDDLLPLGRLPAPPPAKKAFKTAAKKEWAHVIDVNEKLLNFNELVPEMAREYPFELDNFQKEAVYRLEMGDSVFVAAHTSAGKTVVAEYAIALAAKHMTKAIYTSPIKALSNQKFRDFKTTFDPATVGILTGDVQINAEGSCLIMTTEILRSMLYKGADLIRDVEFVIFDEVHYVNDAERGVVWEEVIIMLPDHVNIILLSATVPNTKEFADWVGRTKKKNIYVISTPYRPVPLEHYLWAGRDTHKIVDSKSKFQMAGYESAGQALRRKQDKEREAAGLPPVSRTGGRGGARGSARDLPTGRGAPFTNIGAGRNHSNRGGGNGAPAPAVPPRGGGRGGGRGGRGGFGGRPSHVLDQNVWTQLIGHLQKENLLPVVNFVFSKKRCQEYAESLSKDLTTAKERSEIHITWEKALTRLKGDDRELPQIKTMRTLLSRGVGVHHGGLLPLVKEVVEILFARGLVKVLFATETFAMGVNMPAKCVVFSGMRKHDGTSFRNLLPGEYTQMAGRAGRRGLDTTGTVIILSGDELPPVAELQEMMLGVPGRLSSQFRLTYNMILNLLRVEALKVEEMIKRSFSENAAQKMAPEQQQQIAQMEKALARLPSVDCQVCSPDISPYYDISSEASRVNGFLIHKASWLPNSGKLFVPGRVVVLRNQHFPGNLAVILGNAPSYVGADGVKSNAKAFRMLVLVTPGQKSEEEADIEAKEVVPRWPPILPKGKFPSPDFELTITDTNTITFVVNNILKLPFYQIINKQSLKDIQGATGKLVDLHEELSELPALPEVDWTRTRDVDVQEQLRKRDVFSERLSKFGCRLCEDFHDHYDVLHKRKLVEIDVQKLKVKLSDQNLELLPDYNSRIQVLKSLSFIDDSDTVLLKGRVACEINSAPELILTELILENILADYTPQEVVALLSIFVFVEKTESQPIIPTKLQDGLDVIFRIADEVERVQDECQVQHDEFATKYKPGLVEVVYEWARGMPFNQITNLTDVPEGTIVRVITRLDETCREVRDAARVIGDADLFQKMEEAQNLIRRDIVFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ18</accession>
    <name>A0A1E3JZ18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034112.1">
        <property type="nucleotide sequence ID" value="XM_019174305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ18"/>
    <dbReference type="GeneID" id="30191363"/>
    <dbReference type="OrthoDB" id="10414345at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="39563" checksum="DC49A47CCA46AE12" modified="2017-01-18" version="1">MPPSTANNPSQSGSFQTIVYVGLKKYYDFILFWTSIVAYTLTIVVLATLDSSTCPVPRLQMSADGARLGVNFIVYCFFMPSPPGRSSQQGGQQPLVLGMTRLQQIKIASAVIFTVFGFAALMLQIAHTASVERHEACLSAILCPDSFDKPPCTGVQGQFCRNPSVNPAQALIKDNIRAETIDGGYRFDFDADTLSRTARATSSLLAVATGPTSRSLMCKLFLLSVWSPQQANHFSPFPQSSFNIIVSPVLLLPHLLAPAIHYVVSSPCTSSHQQTQTIPDSTVTPPAYSSTIILPKSSLPAANKTRFQVPVEAAFNCSSSEKLSLGVVVRIAETEKAKELERGDRVRLEEKKGLTRIAGEGKGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ43</accession>
    <name>A0A1E3JZ43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034220.1">
        <property type="nucleotide sequence ID" value="XM_019173515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ43"/>
    <dbReference type="GeneID" id="30190565"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="41961" checksum="43F691C74FD64B9A" modified="2017-01-18" version="1">MSKPFVPTPAISRPGTPNSSGYKQDDTLLRDLGERGERDRLEREDKEKKDARQEQVLPILAYCAASIMMTVVNKYVVSGANFTMTFLLLAIQSSVCVLAVSTVKRLGIITYRDFDMKDAKAWWPISTLLVAVIYTGSKALQFLSIPVYTIFKNLTIILIAYGEVFLFAGNVTGLTLCSFALMVGSSIIAAWSDISSAFSKAPELDPIAGIDIAAGPVSTIGGLNAGYVWMALNCFVSAAYVLFMRKRIKVTGFKDWDSMYYNNLLSIPILVVFSLVIEDWGSESLALNFPASNRVVLLSAMAFSGAAAVFISYSTAWCVRVTGSTTYSMVGALNKLPVAASGILFFGDPASFGNVSAIGVGGVAGIVYAVAKTNQAKVEKAKQARASGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZD6</accession>
    <name>A0A1E3JZD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034271.1">
        <property type="nucleotide sequence ID" value="XM_019173566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZD6"/>
    <dbReference type="GeneID" id="30190616"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="342"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="579" mass="64334" checksum="F49721CC51888662" modified="2017-01-18" version="1">MSILYSCTHLDPPSQPLPPSYPSSHPSFSPLEKLYFCEECDAIRCDLCVGVEVASFFCPNCLFDVPGANVRGDKNRQVCARSCFSCPQCTSSLAIQASDLAPGQEVAEGANAAAGAPYLLVCPGCKWSSKEVGWEFEKPTGIALQLQKIHTQTEKVQSEFDSIKDHLESYITTSNPPTPQRTRVPSRHISHLTQMAAKALHRPVPGMAGKKRAGPGLGGEEKGKEKVGWDELGEYKAKGSWRDLGLEKGLEAGEFMAGLEHGGWEGVAELEKRWDKSWESDRMAKATLPQRIPLKTKLTKRCPDPNCRHLLIQPDTKGIRMKIKMVAANYLPVIEIGRRRRRVQSGDLEEPSGSTLSASGEDAERRRKERRRRTILPNGMKEEEEPLSSPLRPSQTYTFQLALTNPLYDPIQIRLTQPAFPRHAPTPNHQMSVLTPHFTINALKDAWAYDEDEVDEEADGSEDAMSFTTGTGTGTGTGTHSTLGKKRMSVLGASMRDKRHNKELGVEKKGNISKVTVEVETLAEADGPVEFDLEVRYTYRAEGEGTPIENEGGRREERIKEEYKTFTFWVRVHVGDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZS8</accession>
    <name>A0A1E3JZS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034057.1">
        <property type="nucleotide sequence ID" value="XM_019174250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZS8"/>
    <dbReference type="GeneID" id="30191308"/>
    <dbReference type="OrthoDB" id="10312608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="205" mass="22806" checksum="5DB92C57976C3B4F" modified="2017-01-18" version="1">MSDTSSSVQSEGAAHFWRRYELSVENVGPGVDFTSDASTAPEEYHKEVAERLEIAASDVKAQLMIEYEANSKEGRWDENVINSQMCPSGKRVNLCSYLTGLLDNERSPPPGDSLCSYHNHYEFMDEKCPNSSVPSELAPVIVGDLLKENTADIITDVEETFQKESFGWSHTDVSRTSEEDKPSNGTAVFPTVPVRHEEEVPTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZX6</accession>
    <name>A0A1E3JZX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Indigoidine synthase A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034423.1">
        <property type="nucleotide sequence ID" value="XM_019173718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZX6"/>
    <dbReference type="GeneID" id="30190768"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="390"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="703"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="766" mass="80664" checksum="D8214C24FD063EEF" modified="2017-01-18" version="1">MLLSPLRRHVLRTVPRLWPQQRSIVGLSAAKQLWGNRLVISEEVESALHSLDPVIALESTIITHGMPPPVNLSTAQSLESIIRSHSAVPATVAIIDGVIHVGLTAKQLEQIADIESEKGKGAVKVSRRDLAPALALKKTGGTTVAGTMYIASSLGIKVFVTGGIGGAHRGSENSMDISADLLELGRTPMAVVCAGAKSILDIPRTLEVLETQGVCVATFGGKEFPAFYHPSSGCQSPWSVPDVSSAADLIHNSLTLPTPLSTLLAVPIPDEHAEAGSAVQTAVEQAVRGSIEQGIDKRGKEVTPWLLKRVGELTQGTALGLNVKLIENNARIGSQVAVKVAELAKSQVDASSALYVPFSLSSTPSSPSKPPKTVLPTPAPPASLPRPTTLVFGSAAIDLTSTSPHALAPGTTTPGTVFLSPGGVGRNIAEAAQNLSPSHSVQLVSAFGSLPSSAEAVEPDPFGKVLMLELASSGMRADGLVGREGKSTAVCSLTLEKAGDLVAGVADMGIVESLTEDVVEKKIQEEKPKMVVFDLNPLEGSIKSILKTSKSLNIPTFCDPTSTPKLPRLIPALLSLLPSSPASPRPLTHLSPNVLELDLLHSLLAETASEDTSAVSWEYINSLNLDATWRSKAETFTNKKGREWIRQEGMVQKMVACLPYVQSFWVKAGHRGLLHLRLTSTPPSSSADSIVHKLGQQHEGSYLALTVYSPPTIKPEEIVSTTGAGDTLVGGLVAGLVGQNGEAEEVWVERALDRVGRSLRSRRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K203</accession>
    <name>A0A1E3K203_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034332.1">
        <property type="nucleotide sequence ID" value="XM_019173627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K203"/>
    <dbReference type="GeneID" id="30190677"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="193" mass="21349" checksum="5A9C2F8AA6C1ED39" modified="2017-01-18" version="1">MHLLGHNLPDHKPLKIALLTFYGISHKLSARLLPRLGIHSEALVNQLTEPQLTSLSAYLSSPSTTARPSDQTLELAPPGGLALKPVGHPGIFGGLDKGKGRQEDPLNELKIETEKRRAMQADIAHLRMVGTYRGRRHAAGYPVHGQRTQTNAKTAKKHNRVERRNMGTFAFERFTPEDLPTPPTILSLLGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2K5</accession>
    <name>A0A1E3K2K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034716.1">
        <property type="nucleotide sequence ID" value="XM_019172990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2K5"/>
    <dbReference type="GeneID" id="30190031"/>
    <dbReference type="OrthoDB" id="2572925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="355" mass="39780" checksum="B7719E02640E9196" modified="2017-01-18" version="1">MSPEPRSSSNTSMSASPERKAPVILVFPSSEPASPPLRAVTPQNSKDSIAKSSPLPSEPTRTNPPSTRKRSSNINQGSRFPPRTPTNDRQCTNCGERDTPQWRGTLCNACALWKRSRGTDRPLPLLFPLRRSPTPPEDTRMNRQGMENNARYGVMPPNWWAEERKMLPPSDCLEYSLFPRQTMQHTPHHLQSGEYTSPISPKSHGSDTGTHGIISRRMAAIMAQAHAQTRPDYHANFYGTREGTGQEEYAPARHPEAQKPTHGSSPYKQRSQRPSPTFHPYATSSQRQSHAFCPRRIGQPPMSPSSPPTLVSSKEDFMRGAEWLYDMITRAAGMLVRAEDEYLREDNLGLNRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N0</accession>
    <name>A0A1E3K2N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial intermediate peptidase 1</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_00845</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034743.1">
        <property type="nucleotide sequence ID" value="XM_019173017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2N0"/>
    <dbReference type="GeneID" id="30190058"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="356"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="858" mass="94008" checksum="6D91341CB0550BDF" modified="2017-01-18" version="1">MTRYSSATVNELRASSWSRTRVALSRPSRPFLASSYSITAAQRPSALQHFPATKRSPLSLTQTGRLASRGILNAAKDGAVRSLSTSRSLRDVQANLLNGKTVYAPTTTSSSPESIALKAHFDTPTPISLSKDTSTSTLFNLPPLSSPRSLRPLTERTMIHSAALVDRICSAPNDPSGRELRLVVKNLDRLSDVLCGVIDMCELVRNVHPDEQWVQETEKTYEVLCSFMNELNTNVDLYKTLFQTVSHPFPNDPLTPAELKVAHTFLFDFERSGIQLPPDVRARFVHHSDNILSLGRSFLTSASSGPSPEPLIEIPEPERLLQGLPDRFTSSLPRKKRGGPVLLEPGSWEAQMVSRYADNEEARRLAYIGSMRAEPDRVQVLETMLCERAELAHLLGKESWGDVTLTDKMAKTPQNVLGFLTSLAVHHKPSAAMDVAALQRLKAMETADGPIVTLPPLYAWDRDHFGEKYTASLMPDSGLPPITPYFSTGTAMSGLSQILSKLYGITFKPVPVAHGEVWHPSVRRLDVVDEGGRTVGVIYCDLFSRPGKPSSGAAHYTVRCSRRVDDDDYTGDGLAPGWDASLGKGMEVNGDKLEGREGRYQLPIVALVADLGQVAEGNPALLGWTDLETLFHEMGHAIHSMLGQTEFHNVSGTRCATDFVELPSILMEHFVSSPAVLSTFATHHITSEPLPIPLIQAHLQLSQSLKALETHSQILMALLDQKYHSVQYGQGVNSTKIWEGLQTDVGVLPPVTGTAWQTQFGHLYGYGATYYSYLFDRAIASKVWTTLFDRPGRSGSAEDAGGILCREGGDAFKDKVLRWGGGKDPWEMVGDVIGGKEGETIARGDEKAMDLVGSWVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N3</accession>
    <name>A0A1E3K2N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034748.1">
        <property type="nucleotide sequence ID" value="XM_019173022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2N3"/>
    <dbReference type="GeneID" id="30190063"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="644"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="338"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="654"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="765" mass="83679" checksum="D550A50550E9C323" modified="2017-01-18" version="1">MDPIPPSFYDLERRRLENTIDLDLASLSLSSLHSTTSSSSQPYYQTAPQEYQDHTFLSSSSSDLSLEYPRAESIRPSAHHVSGVGYGYGQGPSGTPRAPQSMTSRMSSMSAQSVFAGSSPVSTAGHHASAMTLGAGVFGGHAGRHGKENEPEGQYDSERSTGKLVGELGRVMGAKNMPSRPDSPFSPRSPSPLPSATSQPLNLSYTLSRNDQLLSPPSSREKTMDSRPAEQTPAPKSKTKRQPLGASNVHNVSRTPGPRKTTGKEKPDRVRALQTEGRRSASAPEMRKEVSADITGLSGLLATPAAGHKYGGISRDGDVGGEPAVNIPHTLATLHARLRALDTENSVSRRRVKELEEELEAAKKAVDAAKRSGDKNVKEAVYEKSALEELIRSLRDNLARLTVEVEHNKALVADLRQTASNNGPGPSSQSSSVQSELAALRKEIERLTREVERLGGIVTSGLETQKRARGERTVRMEEAEMEKLVRQVVEAEHEGIRRAQADVERRQAELVAQQKAKPPRPSTAYTFQQPRDISQISQNPTPPPSDDDYDSPTASRPGSRQTLVAPTPEHRPQERKSKSKRNKSKLAYEDRSGGPGSPFPSINDEELEKEFFSPSSKPTKSRTKAYDVSGLGEVLLNGGHDDELPPPTVLARVIAELEDDFKHYKSIYSELADQYKVLDPASVSAKRHVLADHLREVIDTLEQKADQISELYSLLVFSDKTLSAGERRERNKQGVKSVGDVLRMVKGSLGEEVWARLQRDLKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2U8</accession>
    <name>A0A1E3K2U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein ypt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034818.1">
        <property type="nucleotide sequence ID" value="XM_019173092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2U8"/>
    <dbReference type="GeneID" id="30190133"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="211" mass="23361" checksum="E27D93BA8630A6DA" modified="2017-01-18" version="1">MSGPAGQHYDFLIKLLLIGDSGVGKSCLLLRFCEDSWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLIYDVTDEKSFSNIRTWLANIEQHASPGANKILIGNKCDWEEKRAVTLEQGRALADEFGLRFLETSAKANEGVEEAFFTLARDIKTRLIDSQPQEATPVSLGAERGKVDVNKTGDSSSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3X9</accession>
    <name>A0A1E3K3X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynactin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035053.1">
        <property type="nucleotide sequence ID" value="XM_019173327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3X9"/>
    <dbReference type="GeneID" id="30190369"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="422" mass="45996" checksum="A79C2E37294E78CC" modified="2017-01-18" version="1">MSSKYSGLPDIASDTAADIFETVDEPDTLLKPSENNTGDADAPVKPQSEAINAKGLPSRRQAERVFARGARRPENATVSFRPRLPPLSRYGSSSSSDSDEPSPLPRETPAARLRRLKAELAEVEAQLGSSSQTQSHPVPQPQAEGKRKSVLPHRQPVDVVSELANVRERLETMEMRDLPAGEVESRGGEWSERLSKLTAAEKRKEVSVGQSTAGEKDVKLSDVDKRLAALEQAVGPIGDGIDQTNTPLLPSINKHDHLLTLLTQPRHLDAISRRVKLLLVDLDRAATASRRGPGGSAITQPGGGEKATGTDLALTQAEYNQLQSLFGVLPRLDPLLPILTPLLARLRSLSALHSEASDIASALKKLQTRDRKSVEEVKELEVVVESVQKGLGEAVEGIRRNWEGLEGRMKSLEERLQRVERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5J5</accession>
    <name>A0A1E3K5J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035188.1">
        <property type="nucleotide sequence ID" value="XM_019172246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5J5"/>
    <dbReference type="GeneID" id="30189270"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="256" mass="29274" checksum="B279B5D4AF4FA61D" modified="2017-01-18" version="1">MASSIDPELELFGLVTKSQDPSPNFSPFVWITKVDLAILGVSYKTNNKSFYEIRNDLAELVGDPEVSVPTLKVGDTYLQDSFNIALWLDEKYGKNNTLFGPSQNTKAHTKFLEQWVLWTLAVPIQALNRSMMYFRLDPDSAAYYLRSRYNNDIPTLERRVKEVSEPSYIASQWALLRSHLKPLNILLGEHEAKGKRLFFDGEGPTHADAAVFGWYAFTRENEGWREGWESEEIGYVKKWLGNMIELVGGEKELPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5P3</accession>
    <name>A0A1E3K5P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035238.1">
        <property type="nucleotide sequence ID" value="XM_019172296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5P3"/>
    <dbReference type="GeneID" id="30189321"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="310" mass="33803" checksum="07110732AB540860" modified="2017-01-18" version="1">MASASGYNHHRFARAVLKKSRKWEPSLTPMNFQYEGPMKPFLLAVRSQVIPASLIPFLYDIQPPISFVDGCLVVELQDFRRTPESRSRVVMRPAAETLPQTIDVMLERKGQAWDDQLALELESRIIAATSPPLYLGTSIMATRNASLALSITSPAHPNLSSEGSLRQPLSAESDQASSLDRMRKLVLAGSSQGSGAAPFQPDWLVLRSREQFEAMKMARDRGFAPPGSQGPGSIGPRSSVGPGMGLDGKDDGGKRKGKKRPGEEDEAEVAKPKSKKKKKNPQAAVEVEDKKRPSTKKGGDKKKASKKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5P8</accession>
    <name>A0A1E3K5P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035266.1">
        <property type="nucleotide sequence ID" value="XM_019172324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5P8"/>
    <dbReference type="GeneID" id="30189354"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="43377" checksum="F04EABDA9D65B371" modified="2017-01-18" version="1">MSNHASLPSHEYQVPVKRILSKAHLAAFQRSQAHKDILSFIEDLNTSVVGKKLSEAGEGSERTKPVLAVLDQVLELAHATPPVDNKLSRFGNPAFKTFYDKISSSILSLHEVIPELPKEAIKEVEVYFQESWGNKERVDYGSGMELNFLCWLLCLTKLGVFTKDDYSFLVLGVFWRYINVMRYLQSTYWLEPAGSHGVWGLDDYHFLPFLWGAAQLKDHKYLRPKAIHDPEILAEFSKDYIYLSCIQFINSIKTASLRWHSPMLDDISAVKAWAKVNEGMVKMFVAEVLGKLPVMQHALFGSLLRFPSVEEDEQLRKDLEAEGWVDGESGKEDEHGHVHDAGEKGWTMDCCGIPVPSAFAAAQDAKDKGLPALTNRPGIKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5X9</accession>
    <name>A0A1E3K5X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035430.1">
        <property type="nucleotide sequence ID" value="XM_019172488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5X9"/>
    <dbReference type="GeneID" id="30189518"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130783" evidence="2">
        <location>
            <begin position="33"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="58133" checksum="65451C52BFF8A270" modified="2017-01-18" version="1">MAISSRHIIRSALISSPLLFLLVFFLVKPSTPSTSEFPHTPGEPRTFDFESTEAKGWREGLRGGVSDWRDKWPSLGWGSGRETVEQMEVEQVEEDGWVDFDEGLHWTKYEGGVPGYQVFTNLYLSGASLTAITPSQAPSPLASDDAEETDRVQESPFPETKSIISSSKRGVTAGPDRWRIEGPEVGRMEFGKTGYRLGGLTFIFNDGPGPGIYLNTSNSRFRHFVAEAFLGAVRSLASTLPASASIPVPKRIWFPRCGATPSWRDDRGENVWFLSHAVPSASIEDSTGFADRNLAGVTMQLEKVVIIDRWAAHSITGDIAKWGKMNVLVPTVAAPGDIFQQYRDNAIQSFGVSKSKIGSRGLPVVVYLSHQKEPPRLRSEDHAGMITALKSLTSIAEVHIVKVGGMPKIRQVELLSRALVVIGSHSDDLVHVIWMPPSKGSTIIELFETGGFQRDFELMASSLNHNYVAVAGDRVVPEEEWKIAGPSNGERPKGEITINPEVVVRIVEDIVAASDETLVQLGRSRRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K687</accession>
    <name>A0A1E3K687_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035549.1">
        <property type="nucleotide sequence ID" value="XM_019172607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K687"/>
    <dbReference type="GeneID" id="30189640"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="174" mass="19433" checksum="41E614F53383DE30" modified="2017-01-18" version="1">MRPTSLLQGASRLPLTGKRGNKDFYKGTGQARVPGGGHRTGPPGKHVVRGTAKYRLVDEKVRVFVAPTQEALGNTELKPYVATQDLDNHKTFFNPFSHAYGERPRLPSFSPNATPMIAGTSLSRRDYTDFSKRWANLSHDERQFVVMQQRRQWWEGMSKLYGSDVAAPGAQGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6X0</accession>
    <name>A0A1E3K6X0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP citrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Citrate cleavage enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">L198_00478</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035600.1">
        <property type="nucleotide sequence ID" value="XM_019172658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6X0"/>
    <dbReference type="GeneID" id="30189691"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="304"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="553"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="718"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ODO08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126496" checksum="546086228D8EA20A" modified="2017-01-18" version="1">MSLSDFFLARSVVESKADAFSVAIREYDAKQLVSYWLNRSPTPIPTKTESLLAPVQVAQVQWDPATKQLSPPIQPGQGLPEWVFSSKLVGKPDQLIKRRGKAGLLCLNKEWQETGAWIEERAGKPVTVEKTTGTLSSFIIEPFTPHPADTEYYVCINSAREGDWILFTHEGGVDVGDVDAKALKLLIPVGQQFPTRETVISSLLAHVAPAKQDVLCDFLIRLYGVYVDLHFAYLEINPLVVLDAAPGKPAEIHYLDMAAKLDQTADFLCGPKWAIARDISAGQPSAGIKADRGPPMVWPAPFGRDLTKEEAYIQKLDASTGASLKLTVLNPQGRVWTMVAGGGASVVYSDAIAAAGYAHELANYGEYSGAPTEGQTYEYAKTIIDLITRGTPHPEGKVLIIGGGAANFSDVAATFKGIIRALKEYKDGLVRHNVKIWVRRAGPNYQEGLKAMRLCGESLGVFMKVYGPESPITAIVPMALGIGRPVSALTRDVTPLPSAPGTPPNGIAEPVQKSSNVGVVNSDGSREQPNDNIVRFETEPLAGSRPWFRPFDDNTRSFVFGLQPRAIQGMLDFDFSCGRKTPSVAAMIYPFGGHHIQKFYWGTKETLLPVYTSVGEATKKHPDVDVVVNFASSRSVYASTLEILSYPQIKAIGIIAEGVPERHARELLQLAVEKKVIIIGPATVGGIKPGCFRIGNTGGMMDNLIACKLYRPGSVGYVSKSGGMSNELNNILSYTTNGVYEGVAIGGDRYPGTSFIDHLLRYEADPECKMLLLLGEVGGNEEYRVIEAVKQGIIKKPIVAWAIGTCAKMFTSEVQFGHAGSMANSDMETADAKNRAMRAAGFIVPDTFEDLPETLKDVYSQLVSKGVIVPKTEIEPPQIPMDYNWASKLGLIRKPAAFISTISDERGQELMYAGMRISDVFKDEIGIGGVISLLWFKRRLPAYAGKFIEMVLQLTADHGPAVSGAMNTIITARAGKDLISSLVAGLLTIGDRFGGALDGAAAEFSKGLNSGLTPREFVDSMRKANKLIPGIGHKIKSKTNPDLRVVLVVDFVKKHFPNHKTLDFALAVEEVTTQKSGSLILNVDGAIAASFCDLVSGCGAFTEEEAAEYLKNGSLNGLFVLGRSIGFIGHYLDQKLLKQPLYRHPHDDIFYPSNERVVVQPTTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K725</accession>
    <name>A0A1E3K725_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035795.1">
        <property type="nucleotide sequence ID" value="XM_019172853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K725"/>
    <dbReference type="GeneID" id="30189892"/>
    <dbReference type="OrthoDB" id="2575827at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="803" mass="85725" checksum="35970F6016C00C0E" modified="2017-01-18" version="1">METATFATHHVYFDAPPLSPSNISPTSRPGASLFTTTFKHPTAPSPKGNMARRSSRADPMIRTDDEAYEEDEGYGELGQRHPLRRVKEDSKEEEQARQVSGGDAISLPGIKSLLSGAGDPPPVLNSALFQSPSLPSLVPNSPTSPSTAASGRTSRFSSLTSSAAVETSAPGWWHPDFNGNPFSAHQSYRSNTLPHTQTHLFDEHDQKRRRSDGPPPAADNEELARLKWQAQSRNASFPSASPSGSSGPTTPTNWPGRASLHPPSAPSAGVSAAMSRGSLSGMSGSEGDAPVSRRASPRSRNGSLVSGQLAKHFADLSADSPRGSLSAPSAPERRLSVHPPAFHGTERRASSLLRPISTPGSEKPLPSSSLAIPAISRPSSAASDRLRRHSNTQPSTPDGEVRRSSLSDMIKAQSGDDVAMKEGKYLAEKSPLSEPILAAPSPLRASPQSVFLPVPSGRRESTESISSFTAHLAISQDEDRTLSGRGKKRSVEEREDVMSVGESSGSGSGDPGMRGMEVLAEEALRAAQEEEGKRSGEEEDEMDEERDSPGKGPGSGVAGPKYTCSYCAKSFSRPSSLKIHTHSHTGERPYVCHEPGCGRRFSVQSNLKRHAKVHQVGSNGVSKETPVTTTAPAPNPGPKAIVAQHPPHHAPFQPQGQTHMVPHPHPHHPGAHPYAHGQHPMHAMPHMPPGYYFAPGYAPMPMGMAQPRPHPHQQGMVPQGYYPDPRYGMMHSPSVGMGPEGFGQPVGMPQPPQYGHYAEQPPSQAQAPPQEVKGRGRKGSLVKGGKERRSRGTDGGIKEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HFP2</accession>
    <name>A0A1E3HFP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000062">
        <property type="protein sequence ID" value="ODN74241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027797.1">
        <property type="nucleotide sequence ID" value="XM_019180230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HFP2"/>
    <dbReference type="GeneID" id="30197472"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="93680" checksum="9AF97FD46096E708" modified="2017-01-18" version="1">MASSFAQMSSEKLAQLQTQLPDILTDAEKLLPEEKRNEVIRDKMLARIMAQGQHKMQQQGAGMGMQSPMMGMQQGMQNGKIPVNQSQLQQQQQQHLAMQSRLQQQSAAAQQSRTGTPRPTQPMTPMPQGPINTASPQSHGGIVSPQVIRQSPSTAPGRPVGLPMQGIKTLIDNFPKLMELKRQGKLKPEQERLFDQFMSSPDGQNHLREFRAHQARLLVERGLTNPVAHPAGLQPQQTPAMNNMQLPLAAQQQLAALQQQQQQQQQNQQPFPLNPQTQSQSLQNQLAPQFAQNLAGAGLHHNQNQLTPQQMQALQLQRLAAAQMQAAQNGGRAGMGGQGLVPNQAMINQAALARAAQQAQAQQPQNGMMGMSPHIAAQAQAQGQGQGQSPGGFGSPRPGARPPMSLQQMLINIQPSMSRVAPDKVESVKAMLMRLANMSDEERDGAFKASPQWIPLWNRATGGGNQNQLAQQAAQQAQVQAAQQAHAAAQAQAAAQAAAAAQAQMTGSPHVGLQNGTPIMRPGSAPAVAGFNAINNVSNLHIPAGKARGLQGQGVAAGSPNMRLLQPAGDGQQQLPPGLQADPSIVQRLLEQGIPVQQAAQVFARHQQQLAAAAAAGGNPAYPGLAAQHPSGGTPQPQRNITPAMLLAQYSHDMPSRPPPSRPEQIVPDAPAPTDQSLSILSRASWVPNYTDDVRVESMFKPQTVAETGSRTVGRGTLGWRRVDREGVDDWPEGLREAVDEEAEDEEGEEGEGKGRASGMPGQKRRKVQEVAEEVDKALKIPKDSETLLLELFDEHSDVISEASCFSSDSIRQDQTKSAARHRQPNPAYTAKLKAINEGKAAWRRERKRAKVEAAALTVGVGVGARVVEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLT1</accession>
    <name>A0A1E3HLT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028009.1">
        <property type="nucleotide sequence ID" value="XM_019180010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLT1"/>
    <dbReference type="GeneID" id="30197248"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN77302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="46795" checksum="933388B3592C2DCF" modified="2017-01-18" version="1">MSSPQSNNTRSTIFATTILLDGCLPTLGFSRGKVEKEVEPPRMEVRRSSLLSFRDDGDGGEEVQVPPPVEVAEAAQEYMSTVSLTLEQEQDALSRLTLPQWGDATTKYRRYTSEALTARQNQLSAIMSDVYSSRDAWPFNYTLHPKLEEFLHDGGQLVGPDDIAMDHKEYLKRSQRAVKSARGFDELCEASPDTVKIAFTTELNRPLQLVRAPSLLSPDGESGGRSLIGWSLSHPEVSIGCRVTDDSPQWVMRNEGAQKAYGDSVKADIEASEHDIKSLTLSPETTADDFAEYTQRYENSVFVKAAYLTAKRLTYVDDGECTDEGMLREQMETDGEDTADVRLVDGHLVKAAWLNPCMYAVVTGQLPRERGFYTSRHEEYKNSIKEGLAVMQSELDQQERRAETADVGSSAATTWGTWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP08</accession>
    <name>A0A1E3HP08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_08012</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028046.1">
        <property type="nucleotide sequence ID" value="XM_019179985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP08"/>
    <dbReference type="GeneID" id="30197223"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129272" description="alpha-amylase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="32"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="48"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN78093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="56575" checksum="ACDFFAD5AB4F8180" modified="2017-01-18" version="1">MLAQAALALLPLLSLPALAIDADAMRSRSVYQVITDRFARATGSTGACVEADRSYCGGTWSAITDHLDYIQGMGFDTVWISPVVDNIGDETGEGEAYHGYWTLNPNSLNSNFGTADDLRALSTALHDRGMYLQVDLVVNHVAATSSSTFSPSDSYGPFSTNSTIHPFCWIEDYNNQTNVEQCWLGDDSVALVDLNTEDESVTSYWNTWVRDLVSNYTIDAIRIDTVKHIRVDFWPDFVNAAGVFNQGEVLLGDADYVANYQNNGNVNPFNYPVYYPLISAFNGTNQDFTSLVDMVATVKSNFSDPTLLGSFLDNHDNPRFGSYQSDTSLIKNAHAYPLVTDGIPYVYYGSEAGFDGGADPLNREPLWTSNYDTTTSMYGFFTALNGARTAAANASSSFYTDQMTVSRLSDTSILIAKQPLISVLSNSGASASNATVTVDTSASGWAASTSIVDTITCEAFTTDASGNLDVVIYRGLPRVMIESSSKGALCGSNSVDSSSSSDSAAGLTAAVGGWAVAAGVAVAGLQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV53</accession>
    <name>A0A1E3HV53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028204.1">
        <property type="nucleotide sequence ID" value="XM_019179837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV53"/>
    <dbReference type="GeneID" id="30197067"/>
    <dbReference type="OrthoDB" id="10582096at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="202" mass="22015" checksum="CB6EE42C8C5C28C4" modified="2017-01-18" version="1">MSDTFNPTDYATYPGSQVPNVTGNWEADYLMFQATESQAAGEGGSTAVSSAADDGDEFETYEDFVEDATTASSSKAKKARRLEQLGKKKTEDLRSKHRRASSKATLEKKTLLGEINRRTGGSIKLNQVTSVKALRDQLAWLDNAETELAARVGGLSVGDSNATFSHPPGSSWVAEWSSYPPQWFDNNSNQESADPPPEDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVF2</accession>
    <name>A0A1E3HVF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028211.1">
        <property type="nucleotide sequence ID" value="XM_019179789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVF2"/>
    <dbReference type="GeneID" id="30197017"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="46698" checksum="CB747F86507B0F41" modified="2017-01-18" version="1">MRIPRPRPSLALAIESSADDSSAALVDTARRILSLHTISQHAQNAQHGGIHPLKAQALHARNVPLAVERVLRDARQQGITWRDVDIVGYTRGPGMRGCLHVGEMVAKGLAAGWGKPLVGVHHMQAHALTPLLTEHTPPEFPFLVLLLSGGHTQLVLAESVFKFKILMDTLDSKIGDVFEKSARLLNLPPSPSLSPGATLEHYASLPPLPPFASSSSSSPPLLKPLPIPLTQGSAKHVVGWSFAGLLAALSRRVEEHNSTSNSNPQGESGGWGEPHQRAYSNLLQHATTLHLTTKLSQTLSSLPPLLKEKLSGMAVSGGVASNKYLRAKLEACLRESLGEGKGVWYPPVSLCTDNAAMIAWTALLRYDARLTSSSSSSPPLSPSSSPFIQPSSSPPPPTPHIREPDPDRWAGDGYALDLRPKWSLEDLYDDVPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I165</accession>
    <name>A0A1E3I165_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter particle component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028294.1">
        <property type="nucleotide sequence ID" value="XM_019179747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I165"/>
    <dbReference type="GeneID" id="30196970"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="28633" checksum="71CD3D18D16DBAFB" modified="2017-01-18" version="1">MSRPSSVSTTHLPIAPTIPPALHQLANPAPALIDAQLPGYLLPPVLHLLRQSSTHVVRKRRAQEEELRSEGLLPPRTQIEDEETVIEEELAKRIERIGLMAGGLIAEKLTLARPPLASHLDIIKFVCKELFLYVYSKQIDNLRTNHRGVYVLQSHSFPPLAGLSSYRGAAADMETAKTHLLFPQALLQGALTRLGMHSVVTAESSGLPQCTFQIRTTKATATTPSVAGTPNPSAGLTARGHPGAVSTDGPASVAMSTGGSASTGLGIGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I2C6</accession>
    <name>A0A1E3I2C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HIR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein hir1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_07727</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028332.1">
        <property type="nucleotide sequence ID" value="XM_019179715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I2C6"/>
    <dbReference type="GeneID" id="30196938"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000701">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000921">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="390"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="589" mass="63477" checksum="8EF17E639B724B8A" modified="2017-01-18" version="1">MRVTKPNWVQHTVGEKKAKCPIYSISVHPDGTRLATGGLDHKVKIWSTLPILDQEAENEEQNPKLLCTMAAHTGSVLSVRWAHHGRFLATGSDDQVIMIWGIDPDGGGRLWGSDEVNVENWKALTRLVGHVADVVDLAWSRDDSMLASVGLDSTVWLWDGSTFERLRKLDLHQGFVKGVCWDPVGAYLATQSDDKTVKIWNTEDWSLVESVSEPFKTSPQSTFFRRLSWSPDGAFIAASNAKNGPVFVGAVIDRDGWGSEISFVGHENTIQVAAFNPRLFFPQGEPKGRATASTVLALGANDFSISIWRNTLHKPLVVLKDIFGADLMDLCWSNDGHHLYGSAVDGSICAISFEKDEFLDLAEEGDTDIVLGEYGYEGRMGKRGKAAAAGAGALGPTSSAPSVSTSFGPTTTTSTHVNVLQPKKGKAKRRASFLPPAPGGGGTNGFHPPSHTHTQGRDPFSGPIQGSSSQVGLEGQRMLQNANAYPTSPRTGDKRKAPSPSSPKHSSSLFRPAPSTSSSQALTQTLGTGADGGGAVRAAFQRGYEQGRAEAMEEAEVEVRGMVERERKGIEEAAFRRAVEMVRKEGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I550</accession>
    <name>A0A1E3I550_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028352.1">
        <property type="nucleotide sequence ID" value="XM_019179664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I550"/>
    <dbReference type="GeneID" id="30196887"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="541" mass="58036" checksum="582E548ACD5E2E82" modified="2017-01-18" version="1">MSSTLAPEVLSPDNPITDQTIADLYARLPPAIAPLPLWPPQGKDLEDYTSILQGMWEIWKDVEYMDDYAPNVDEERFPRKDVRWVERGESGNESGAWAWQCDVRDQTLKTSSGLLEGKTVCLKDNMTLKGVPCLIGTSVIQDWTPSTDATVATRFLEAGGIIKGKAVCENLSLWGASCSAATGPIPNPHAAEYSVTGSSSGTSFLVATSAVDFGLGGCQGGSVRMPASAAGIVGLKPTHGLVPYTGVVSIEATLDHVGPMTRNVLGNATLLQAIAGADGIDDRSTAGCPFPSQVPAYPELLKQGVSGLRIGIIEESLDMPLHDERVSELVVKAAEALRAQGATVEKVNVPFHVEAPKLWAASRFSASRTMLGQATGRRGLALNEYTEKLLPLTQKKVDSMHCGGYNGIMNGLWGWENKSPAIVGKATNLIRKLKDDYLAALSKYDVLITPTLPMLPRKLPAKDAGVKELMQNAAGLTGNTCPFNLTGQPALSFPVGILPTQEVDGAKLPVGMQLVGKMYDEATIYRVAYAWETAYDWKTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5G6</accession>
    <name>A0A1E3I5G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028378.1">
        <property type="nucleotide sequence ID" value="XM_019179610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5G6"/>
    <dbReference type="GeneID" id="30196831"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35413" checksum="790CD85806D4177B" modified="2017-01-18" version="1">MTQVQTNGHLATNGVHDTNGVKPEPSLEERTPEFGFEVVQGFFVQNGPKPKHVAFEEILQKSFGLVDQSPDRWTNLKSSLKKLQDEATEGVQYKVLFLGRHGQGWHNFGNAKYGDDWDHKWALLTGDDEITWGPDPPLTPLGIQQAQSIYAAWSREVKQGAPVGAGQMKWLVSPLVRTNQTLEASWGELVEGKPEAWEDLREIYGYHTNDLRYTKTDLQKRFPNVDFSSITEDDDLWTPEPRETYEHAGLRGQRAMDRLFSEGGPSETFISVTAHAAFYRSLLKVLNHQEYELETGEMIPVVVKATKLSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I6B9</accession>
    <name>A0A1E3I6B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028380.1">
        <property type="nucleotide sequence ID" value="XM_019179612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I6B9"/>
    <dbReference type="GeneID" id="30196833"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="267" mass="30202" checksum="36A0A23FA3C6EC8F" modified="2017-01-18" version="1">MPYWESAGNVSVWGASVVLKGSVFVVRRNATLSTMACPSTMTLRKLELLAVKRTMQSRGHNKLSPRSSVKRKASPINLAALKKRLFKSPEPPELPAPKRSRLDKEPSAPASSAGVKLWRPPGQEKTASPDPPTVSDDYSSLLSSVEEMAECSLAADRLTFEMEIIPSRLRHSIPTSLGRDKVSAEVANLVARLERSNDGELKREKEQQQELLRGFRKKKRAWERLEILKKEDWEQTSAEALRANKTLNQLKFHKRRRGLIARQWRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA55</accession>
    <name>A0A1E3IA55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028488.1">
        <property type="nucleotide sequence ID" value="XM_019179542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA55"/>
    <dbReference type="GeneID" id="30196759"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="497" mass="56418" checksum="7D0825ABA29CDB8D" modified="2017-01-18" version="1">MVMDQYERLSDVLKLSAHVTRVLGQNPGQMTLQGTNSFLLQPPSNPHAPLILVDTSSPHTAQQYVDLLFLHLHHLGLESGIRETHFESAAAQMTLRNFKEENRENVQKIVKEQRDFDPWRDHTGLVEYGPGSSWVKDFDGKSHERKLPVVEHIVLTHRHLDHVGALPLLLKTLKEHGCPPPKLWKFPSPDEAELNASDRDRPSSDSSIWQSLPPGTYTPLSPFQPFHPILPGLMISIIDPRYRSLLKYDKDGRAKWNEVPEIARVSVRCLRTPGHTADSVSLVLMEGEKGVFTGDTVLGHGTTQFNDLSSYMTSLRTLLALKPKVLYPAHGNHLIGPKKCLEHIQTYIAHRQTREDEIATLLQRFSKGKEESLAEALLEMKKQLHEKKEADNKEKGPLMLDRKKAVPLPSFDEERRRLESLARLDGVLPMSIITRLLYKSENERLLFAASKNVNAHLEKLIKEEKVKKGQVTVVRLVEGNVEEEKEDTDGWEWVGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAG4</accession>
    <name>A0A1E3IAG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028479.1">
        <property type="nucleotide sequence ID" value="XM_019179533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAG4"/>
    <dbReference type="GeneID" id="30196750"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33795" checksum="72BE10C1BBB7A388" modified="2017-01-18" version="1">MPPKISDVEARVLEALRAANRQEKPNLAELSRQYNVPVKRLRNRHKGEDTAGMDSSPGWLGDASDKALVEDSANQIIARAWEGDAEDAPTVGSKWVDRFHQRTESLHRVKQKSVELARVAALEPKAIAKYFREFMEVRDKYGIQLGMMARKTLDEKTAAAEVREKRKANKRSLVSSVLESGNCRSQDWAKKQEFEAKQRKGEHLSNKREVYLRKEDGGWRQVLQGIKDIGRWGENAWAKRMGPYSRNEGWRVGDKVGFMYMEETVGYGKNVRATEREDVLYSDDMEGSVEENDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBB7</accession>
    <name>A0A1E3IBB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028597.1">
        <property type="nucleotide sequence ID" value="XM_019179456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBB7"/>
    <dbReference type="GeneID" id="30196671"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="20343" checksum="E65212123D2731B1" modified="2017-01-18" version="1">MSLPHSAYDPRRVFRFNLPTFEIGPRTRSIGTYVSGGVFALAYFLLFDAATLSSHAKPPPDAPYDVVPVHMAFVDWIPAIISTFGFIITSILDKSHLTSAFSSDPWASEGSAAWRARVVLFIGVAMMAGGLAGSLCVLILKYIIPDFSGYLWYGGANVACNTGIMISAMILWIAQSGSDEYEYQLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBY2</accession>
    <name>A0A1E3IBY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028650.1">
        <property type="nucleotide sequence ID" value="XM_019179402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBY2"/>
    <dbReference type="GeneID" id="30196611"/>
    <dbReference type="OrthoDB" id="10412685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="35464" checksum="B16E4CFCB4710418" modified="2017-01-18" version="1">MSWSYILNHLSCINTSPINTSVKTARRLLTPADYLPYLVFPTQGSGPLIVIVVIAAEFSHRFEPDAINTELTDKGQALPNHSSAVTFPASGSVATSHSTSAGKSIFLNTISTAAFSGLHPSLLDPSSSTPPAVPDTPSIKKRKRDPDDDGEQLRSLLERSAATPEAHFLLGTLFSFAGWHDDVPGECEEYELPLIPLRGPSNKWLYQEYSIFEHQPEGIPEKVDRKGKGKAKEAGPPSPALAASASPIQTINSLETDADYLTSNSNKMGLEGQCSDELVRYEGEGEANSSKVTLEVLDERDRLSSEGYVKEREDWINGFIGRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICC7</accession>
    <name>A0A1E3ICC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028638.1">
        <property type="nucleotide sequence ID" value="XM_019179390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICC7"/>
    <dbReference type="GeneID" id="30196599"/>
    <dbReference type="OrthoDB" id="10515297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19731" checksum="706F19115E0EB7AD" modified="2017-01-18" version="1">MMVHVPEADVLKSAPRHQLSARYPSPGGDSSGEPEKGAKNPEAWAGLQQQQHAQQQALQPPQPQPLAHDRWQRSDLRLQYAVFVAFAVSAIRLGAGLVLTWKGRTAPGHVLYDYAGPGFWLSGAFVWYPSVIAVWRRVPGAQLRARRWNEITMAAVLVLIVYTVGNFVLYYRYTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDY7</accession>
    <name>A0A1E3IDY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028802.1">
        <property type="nucleotide sequence ID" value="XM_019179185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDY7"/>
    <dbReference type="GeneID" id="30196383"/>
    <dbReference type="OrthoDB" id="10358058at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129732" evidence="2">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12793" checksum="99AAF7BD21838515" modified="2017-01-18" version="1">MLFTTYVFLSPIGLTSTLASPGPLAARQDDDPASHPPSAQVIKPEDKDMEWFKAAYPHSLSHSKLSFEDLCPPRFNKDSEETDKPIWVRTAFFADSVPSEKKRYDPEGMSFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE39</accession>
    <name>A0A1E3IE39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028821.1">
        <property type="nucleotide sequence ID" value="XM_019179204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE39"/>
    <dbReference type="GeneID" id="30196403"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129739" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="178" mass="19151" checksum="CF34AD9ABB79F3E1" modified="2017-01-18" version="1">MLAIFALLPLLALASASPIQKRYTGVKIKSGLGDHCLTPLFTQFQEGTPITTASCADAKTWDINPGSGSVLLHGTEFAMDAGTGTDNHEIVKLWTSYPGLFQQTWFYTDDNRIAITGGNQCLDETNAGPQTYECTPWNDNQVWHIVESDTPTSFVTSSITPLPTGSASVSDNGTVTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM6</accession>
    <name>A0A1E3IGM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">L198_06985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029097.1">
        <property type="nucleotide sequence ID" value="XM_019179003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM6"/>
    <dbReference type="GeneID" id="30196196"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="288"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="572"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="427"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="672" mass="73445" checksum="BDEB891ACDF15979" modified="2017-01-18" version="1">MSLPPARSAAVQIVRPPSPSSEKAKDRDKKPSPEKRDAPQRICRNVMIYGHCKYQDSGCIYYHPPPGVDPTASQNGSPVAKNASPSPAAPKLLSKDKASGISAEHLAAPVFVPKFESSSPRLGTPVSAAAATSTPPAWPPLPSQGGLSGLPTFQPDSAPFTPQASLPVTQAPSSAGVTPNAMTYDESLSIIDPNAGLDQSGLYLHPRQPLDQHLFASTMPSLSSNPLHPAHPHAFFVDDEIRRTLQTRQEAVYVGANGGSAPGLPQELGVYHSLVPLPLTSKNPVSSGQNPTSKVYGLSAPVYRATSEVDGSTYCLRRLEGYKLVSEMAFGAIDTWRRMRHPNIVGLREAFTTKGFGDNSLVVVYDYHPSATSLHDEYIATGMSSQDPTKRRGPIPERILWSYITQIANALKAIHSSGLAVRHLDASKVLLTGKNRVRLNGCGLWDVLAFDQQTPISVFQQEDLMQFGKLIVSLASDLFQPSMPQQSLPAAVDHISRQYSPDMRDLVLWLITKPPGSGSTGKTIDEVIKMMGPRILNELDAMQSYTDTLENELGSELSNGRIARLLTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSIGVDGKPILDLSHVLVCLNKLDAGLDERIMLVSRDDQSCLVVSYREIKHCIEAAFNELRSSNDPHRVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHJ3</accession>
    <name>A0A1E3IHJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029138.1">
        <property type="nucleotide sequence ID" value="XM_019178861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHJ3"/>
    <dbReference type="GeneID" id="30196037"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="33558" checksum="2D675F2916AA3AA1" modified="2017-01-18" version="1">MAFGDRGGRGGGGRGGGRGGFGGDRGGRGGGRGGGRGGSFGGDRGGRGGARGGAGGRGRGAPRGRGGPGGGRGGKPGMGRAGPGAVTLEPHKHEGVYIAKGKEHLLVTRNMTPGESVYGEKRVSIATTNAEGEEEKIEYRVWNPFRSKLAAGILGGLDNIHIKPGAKVLYLGAASGSSVSHVSDIVGPEGVVYAVEFSHRPGRELIGMAKKRTNVVPIVDDARHPQKYRMLVQMVDVIFADVAQPDQARIIALNAHHFLRNGGAIVISIKANCIDSTAPAAQVFASEVNLMRKEGIKPKEQLTLEPYERDHAIVVGIYNRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ56</accession>
    <name>A0A1E3IJ56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029084.1">
        <property type="nucleotide sequence ID" value="XM_019178990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ56"/>
    <dbReference type="GeneID" id="30196182"/>
    <dbReference type="OrthoDB" id="2573465at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="712" mass="79700" checksum="68F95FA7103279F2" modified="2017-01-18" version="1">MSANPPILAVPHQKSSPETHIKRYLSSLEPYVNEHARAGVSTFEKALRGEPPPESEGAPTIEGKLNMFGEEGEELVTRAELLAKLSGSGVKPAQPVRRQPLKDVQTASFKLPLDSLVHKLDKGKTNGVEKKKAKGTKSKEDVFEESETESAQRRLQRKTRRREKAAITKPKPPTPPPAKKKRKSKPPSVDGSLEGSEESEEVDDRRKGRRRQAIPAFVKNYQAKNVQEAAKPVKKKQGFLNQGKASMPICLPSEKPRLATAQPFSEDAFLGSQGALRRSHDEDDTFGWKLPHKRPLSSLPSVDVDDAPARQTSRPRSTRSPVRAPSHTSLPSSSAQQHAPSAHNSYSRMPPPGVANSPSWHTEITEEQASFVRKESGRQAATPGPAQNVALSLDPVSPPHIPRVLTPPRPQPEEPSPGTLREVFGGKSFVWPKNRGMDMSFGQTAHDETPARYHQPSPAFPPHHVSTDPAPDVYRPHNTLPQSTTIPVFVHAPPFRSEDDMEYQPVWMHEESRDDIKIPRSGYEEYGEDEEYQQDRHYEHEFPTHRFTSTPMYDRQLSFAPYSSQNAPDQLAYPHHHHRMSYDHRDLPQPPIFHAPSAVRREPPQPAPPTVNNTLDRSFISTDSPLPKMYELPSPQPYCYPAVAARGYAMSRNLDEGRYVRSWSAGGRRDIEVVDERYQDARGGFDREDDDGHLEVTEGQWKSLWSGGAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK67</accession>
    <name>A0A1E3IK67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029383.1">
        <property type="nucleotide sequence ID" value="XM_019178682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK67"/>
    <dbReference type="GeneID" id="30195839"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="64015" checksum="BFC028F9F0B3FE44" modified="2017-01-18" version="1">MLHREAPKARSKNLEDIAQLEEQGLLRKVEDSEDSGSPPRSSSVGSTARRRRGKDEDGVRLEKIEIDEQVHSTGLTSRRDKEAFALLVLLCELQGIPLGLTFGTLPFLLKSHLSYSQLALFALSTWPYSLKLLWSPIVDAWFVKRWGRRKSWIVPVQGVVGVGMWIIGGRIGEWMEAETVDVKLLTTVFGSLIFAAATQDIAVDGWALTLLSQPNLSYASTAQTIGIGIGNALSFTVFLAFNSADFANKYFRGGNKLDYGLISLGGYLRFWAVVFIVVTIGLAVFKTEDPVSDDDPDMDVKKVYKVMWSIVQLKNIQSFLFVHLICKIGFQVNDSVTSLKLLEKGLSKEDLAVATLLDFPAQMAVGWLAAKWSRPPPASPVANEGRKSAGADAHVLKPWLYAFWARLAMATIATLVVAGFPSSGVGSGYFSLIIATMLFSSLTSTVQFVGICAFHTQIADPLIGGTYMTLLNTVSNLGGTWPKPLILHSIDVLTVASCSIPTLHAYSPGASAASPLSKVGLEATYGECVSEAGKHACADVGGECVVARDGYYLMSAVCVTLGAGLLIVFILPMVRRLASLPMSAWRVKIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKE8</accession>
    <name>A0A1E3IKE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">20S proteasome subunit alpha 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029235.1">
        <property type="nucleotide sequence ID" value="XM_019178752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKE8"/>
    <dbReference type="GeneID" id="30195909"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="35563" checksum="BA83DD9B7B8BC61C" modified="2017-01-18" version="1">MERSPSTRTPRIEPSPLSFQDLYSAAMFRNSYDSDNTTFSPQGKLFQVEYALEAVKQGSAAIGLRSKTHAVLLTLKRSTGELATYQKKLIRIDDHVGVAIAGLTSDARVLSNFLRQKAMQSRMTYGRATPVARLVQSIADRAQTNTQEYGRRPYGVGFLVIGTDETGPHLFEFSPSGTAFEYYAHSIGARSQSAKTYLEKNFDKFEDASLPELINHGLSALHDTLQQDKHLSVLNTSIAIIGPASDESANLEDVRASTAAQKGNFRVWENEGVDGFLRAWRRSRGEPEDGPSEEPEEAAAGEGAEGAAPAAGEGEGQQGEDVQMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL27</accession>
    <name>A0A1E3IL27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029220.1">
        <property type="nucleotide sequence ID" value="XM_019178737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL27"/>
    <dbReference type="GeneID" id="30195894"/>
    <dbReference type="OrthoDB" id="2568716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN88411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="38025" checksum="F0923EE04717BA35" modified="2017-01-18" version="1">MAPITKGDLILVTGASGYISSHTAKEFLKQGYKVRGTVRSQEKGEYLRNLFEGLGQFEYAVVEDIAKDGVFDEAVKSVDAVAHLASPFYTANVKDPQELIGPAVKGTTGILKSIQKNNPGIKRVVITSSVASVMSVRSRKTPVIYTEEDWNVDSIKHVEENGVNSDGGESYRASKTLAEKALWKFIEDEKPTWDAAAINPPLVIGEVIHQCDDPEKLNTSVHYFWEWLTGKKSESDLPAPGANWVDVKDVALAHVRALTVSEAGGNRFIVGAGPFAGQDYVDVLHKRFPDLPNIPVGKPGTHDEIVKDSNVFNGAKATKVLGVEYNTFEDTVVEMTESLQKRFADKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM05</accession>
    <name>A0A1E3IM05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin p58/p45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029542.1">
        <property type="nucleotide sequence ID" value="XM_019178386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM05"/>
    <dbReference type="GeneID" id="30195532"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="488" mass="50446" checksum="EEFDD313777E5798" modified="2017-01-18" version="1">MSFGNFSFGNKPAAAPAPAPAATSPFSFGNTSTQPAAPSSSSGGGLFGNTSQSQQPPQQQPAAGGSSLFGSFGAKPAAPAAGAPTAGGLFGSLGAGQQQQQQQQQPATGGGLFGSTTQPQQQQQSGGLFGSTANQQPQQQAGGGLFGSTGGQQAGQQAGSGLFGSTAQKPTGGSFGPTTQPAQQPTGSGLFGSTSQPAQQITGGGLFGSTTQPQQNGGTGLFGSSSQPPKPAGGLFGNQPGGTSLFGQTTQPAQNQQQLQTSTNGASGSGGIEKTAKFSDLPEAAQKYIEQLDASIKNQKSVATLLNTEPLGLAIWQTGLDVKTATEDYGSISHTLKSLKNSISQLHEKMIDQSRDVERLKEIWDIYSSGDARMAQVKLAAYKEFPQEFFSRVADQMEEKAARYKKTIAQLNRAIVSLSSESHAPSPQAIAQTINNHQQAILALAGQLDQMQVRMNGLKQNFAAEWRDKTGSVRDPFEMAREERGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS3</accession>
    <name>A0A1E3INS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029771.1">
        <property type="nucleotide sequence ID" value="XM_019178333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS3"/>
    <dbReference type="GeneID" id="30195479"/>
    <dbReference type="OrthoDB" id="2574480at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="729" mass="77023" checksum="843049CE565D683F" modified="2017-01-18" version="1">MADHPPDYAPTLPQILVVPLPDAASFFCGPSVQGEVFVKGLGAGEEHGVQALRAKLQLQSVLPEAPPIDLYPFPEQTLYPAPPSLDEESTSTARFPACHQFVIPLPATIPPPDWVDSSTADPDGEILPGTLNLSALSKGEVRYTLSVILSLSTGQQVEATIPVEGTPQTLFATYPLSKKEVEHVQTKKGITTRLLLSSDTPHLGDLVHLGVEIKPSTLSTSEQAGYQKGSTSAEQEAKGILRRMRRIRVEFYRLVTIHSSQSSSSTPPAPEQHYTLLHSSGKSLRYPGPPPLPAPRLLFTIPTAQTGHLAERTWGEINQRAGWHEVQFGVRVRVGLGDGGSAGPSGPASSESEDDGWTIEHPIVILPKIYRPPSASSSTFPDTISEPPSPILDPEVEQQRAREAYRLKGRDIVGAQGTTRAEDVPGDDLPPPFEPGRRPSQAGPSASYPPPPVEQEPEAAGSGPSGLPTFLESQAQEERRRGSVSVVLPHRDTGKERESNDVTPAAVEPVREELRVGRDGLSGELATWVEYDGYETFSQPPPSLAASLHARGSMDPPQPGELVQVVNGVVEDVVARLGLDGAGQAGGAVELMEHLGLGDGTRVVDLQDDLPPGIDEPSLPALPSFNSPHSQPPPRTFQQFSTQTLPTNAHPLHSPPLPATPPPPHESQHAPPSFDASQAANAVGGVAASGPVAGAEEGGDVVSAPGAGPEGQGAPPGYDRGGLPPYSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP00</accession>
    <name>A0A1E3IP00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c oxidase assembly protein subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029677.1">
        <property type="nucleotide sequence ID" value="XM_019178239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP00"/>
    <dbReference type="GeneID" id="30195385"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="50859" checksum="BD8A747D0050D559" modified="2017-01-18" version="1">MLVPALNRAVCRSLRADAQATRFPHRAFSSAPSKHSFARQTPRPINLPFFTPSSRTSFFFPSHTYKFPRSLSTAAPKAKADPVYDDIPRSLPYWLYGCSAVVFGIVVIGGLTRLTESGLSIVEWNPITGILPPITKADWDLEWEKYKVSPEGIMMNANINIDEFKKIFYMEWGHRIAGRALGMGFVLPTLYYLARYKLPRPLPMKLLLIGLGIGFQGVLGWWMVKSGLDEQIIKDNTVPRVSQYRLAAHYTAAVALYVGMLSTAIGIHRDMKLAKNPAIIQALNNPAVKKFRGLVHLSGMMVFLTAVTGAFVAGLDAGLIYNEFPYMGEGFVPPTEDLYDQRYAKSGSDKIWRNMLENPVTAQFDHRVLATTTFTILCTLPFAARRLPFKSSRRLAGLATAAAVTQVSLGISTLLYLVPIPLASMHQAGSVLLLTAILALGGSLRKPSKMMKMMRVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ57</accession>
    <name>A0A1E3IQ57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029836.1">
        <property type="nucleotide sequence ID" value="XM_019178117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ57"/>
    <dbReference type="GeneID" id="30195262"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="475" mass="51839" checksum="30AAE4396433D8BF" modified="2017-01-18" version="1">MIPPILSFFASLPSPPGPHPVGYAHITCPPIAPFAHPFPLLKSTSKPAFSLSHVGYAVFYPCNTDYEDAKGKHQERKKGFGWVPEPMSEIIKGYGKFAGGKGAVSWFVRPLGYFASRLLMPVYPLAPISPAQRPSAGYPLIIFSHGLAGTRHTYSQYCAALASEGYAVLAVEHRDGSGPAVMLPPDKEGGEPKVLYYTGVDDIQWEEGEEQPVNHARTLQLEMRSREVYEVYNSFINLTSATPNPELEKTVVIEKLEGNDKQEERQAWINGLKGQVDGDDLRLIGHSFGGGTMLHLLQTSVPHPYTPLPTTQALVLDPWLDPLPLPSDILSAPPFPSAEHKTLPPLFVVNSPGFTEWGEHFSRLVGIAKGWKNGEKNRAGLVTLLGIGHQTFSDFPLLSPTPAHARSMLLSIHTLSAAFLSSPSTLASLPEIQGQKPDGGQYEHEEKVNGEGERLMKGKKGRDGQVVVHLLADDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS03</accession>
    <name>A0A1E3IS03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030029.1">
        <property type="nucleotide sequence ID" value="XM_019177990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS03"/>
    <dbReference type="GeneID" id="30195129"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="526" mass="59432" checksum="7769817C52D5CB27" modified="2017-01-18" version="1">MAQDRKGPLGPPPALEDDFDLPPSYDSSLATAAAPGASSSTAPSGDGHRAVPDHIRFFFTPPVNSEPVSSDERRDATARQRFANVQMVKKGNRIETWDPILSNPNTLYDFIRYMASVPPKVNVRCRGWHMETCERETIIDGRTVRRGEQTSVIDFDFTIDLTDIIDHSENSAQVHLSTALPWQPAHRGTNSQTYSAAFHPPSRHNHHGRSREDEQYISLAENEDANTTLPGRSLGHREEKQDVEWQTWRTGKGLPVWVDRRDVPEYEEYLKNKGKGKGRGSGSVRLENDSEQPLLDEELSIEGTSISPTQGQGQGHARANLKEWCKAYCADRGVLNEFSLQKDLCGWDLDGVQSAINGAIRSTGYSHPNLEVTLDVDDRVVIVHPNNFLSRILGNSFVYFLSWLFMIYPLIWFWKRWSSRGGAPWDVTVATYALKFYPPLPHTFPSEPLPDAQSRLPSLYKLNPQLPKEPQLVQGPKGVHYLVGRKEGGWFREWEERIRMGVRTRFRGELVGGTVGEDQRVELDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU36</accession>
    <name>A0A1E3IU36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030241.1">
        <property type="nucleotide sequence ID" value="XM_019177857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU36"/>
    <dbReference type="GeneID" id="30194991"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26283" checksum="276AC32CBF6EF882" modified="2017-01-18" version="1">MASISPVRVAGTVAALAATGFLGYAVYFDYQRRNSATFRKSLKKQEKKLAAVAEADAKQQKEKDNLALREGFLRTQLEPVPSSPDQQEAYFAEQANSGELAIAKGPEHYVEAALHFFKALRVYHSPGELLAVYQRVCPPEVLEMVVRLIGLSQGVASSLETPEREPASVNDIDDTPSASAQAKAVEEAKAAATAAVAEAVAESEKEKEEEKKEEEEVSSPKTASQGSGAEWENVNEKPEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUR1</accession>
    <name>A0A1E3IUR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030077.1">
        <property type="nucleotide sequence ID" value="XM_019178038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUR1"/>
    <dbReference type="GeneID" id="30195179"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="287"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN91451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="684" mass="73642" checksum="F320496AD07B1C54" modified="2017-01-18" version="1">MFNNPRPLSPSSPSHTYDPLSFTGFSNGLPAGSIASGSVTGAASGGGDELDPWSSAPSPSGGSRPASTLNPSPTRFGSGSEALQNLIVDPPAQYLAILDQLPPGTTVTSLSKYLSDTLPAPIIAKIVTLTNDQPSSPRSSLVCALALFALAQASHISDPLDLSIEILSSALSQGDLPPPKVSHPGSFSPAKPNSHHSSLGPDPYPTWDTPSQDRTGYTPPSSLFRHPPVMASDSSIHIDDPYAPDPLAALESQHGGGENPGQGSGGLSLIQVEDLEPEDMARPRGWWKDLERVTVDLIPEKEGWFLQKYRLSFTKRGDQAVTRRFSDFLWLVDILGKRYPYRLLPPIPPKRLNPDAAFLEARRLSLQRLLSSLTSHSVLSQDPCLTTFLTLPSPGFEGWRKRTSVALEEEGPSSPSLALRVPRDLEPKLLALRSNLPQLLSNLHKLITLYERALTRAQAEKGDSERLAGVLEGLGEGLKECCFWNSPGESGDAPKYANTGDVCEMCGSLGTGVGDVAKGYDKVVGVQQKRIENLQKHLESLRSQRDLHLALHALFSRWAKTQAANPTSSLLTKISSLNTKSSSLLSSPPLPSAPPAKRSTWESQLSKLRDDISLARAEVEVWRGKEVWMKALVWEEVAKVWHGRQGVEGGVGWRALGAGERGVGEGMEGVWEGVVGALEGVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT0</accession>
    <name>A0A1E3IVT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030326.1">
        <property type="nucleotide sequence ID" value="XM_019177575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT0"/>
    <dbReference type="GeneID" id="30194706"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="201" mass="22202" checksum="2A25352A4863DA63" modified="2017-01-18" version="1">MSAPQSQVAQTKVENDQSLVVFSHLSTRHTTSPPSPDDKAPSPPLASAYDIPPSALEEGGGLVNSDGRVWYMLSAPLERDASAVKEIVVDTESKDQGWSSFPENHGTYDVTSSWFDLTLLRDGKEVPNTRLDVQHNVHAGKEFKSHTNTIPSTHPFVKEMQKGDCITLWARALYPGWENHVQRASIAISYDVLAEDSKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVX6</accession>
    <name>A0A1E3IVX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I inositol-1,4,5-trisphosphate 5-phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030376.1">
        <property type="nucleotide sequence ID" value="XM_019177625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVX6"/>
    <dbReference type="GeneID" id="30194756"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="905"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138684" checksum="4D10479F3B0AD468" modified="2017-01-18" version="1">MSGGSTPPSESVEEAPRSIASLRSRFENLAAGNDATVPSHNKAASVSSIRNGHLSAGNEVPARPKPVPPPKPVSRPITPAPTSPLPTEDVQPQLLPRPPAVTPGRPTTPKPAFSNHQSTPSVSALAESHLRAESPIPPRSSSPTPSLGARRAAPAIPSKPASAASSAVPSNAPLVNITLGGSENGEEEEPAISVKALRERFSGQGQAAAERPPIDVPKAVTVPVVPRAVPAPIIQRTSEDGETTSPVALSPSPEEIDSHILAQVTSRQPELNSSPSSIGHSSLPSISRAASPAPGPPPINRAHKPPPRPTSTAPGSTESSPPPIPPNRPALPARSPTISSEAPLPLPPRRPTVSSADSLEPATTYTAPPPVLASSPPVHVAPGGPPPLPDRARASTATRTEPEARAAPGPPPPRLPARNNTISVHINVAPSSPVGPPSHPSSPSRKRTGSGTLPPPPLRSAVLNSTVSNTASPPRRASTISHRVPQPQPATIPQSHSTDNLNDDRQLVEADSEDEDAEPPEDAAILGLSAQARRLLEDHPDTTQANRKLPAFVPDVRIKDCHHVSAFAVYGRYICTGAHHVRIYDTMLSDHAIQVIDLKEHVDGPGGGGKIKETKVTAMGFRPGCSEAEEGRWLWCGTKDGHLWEVDITTGEASAFKAYAHTSAVSHIWRHRQSVLTLDDSGKLLVFEVVQEADSKPILTRTLRIGEKFTFAKMLCGKLWTSSGPAARSVTSASSRGPTIRIYDPCCPGNMPPPKSLFTTEWTGAVTSATYMPLDRDNIFMGHEGGYVSRWDGRELVCVGVMKVSNTDVLALEGVGEYLWAGNRKGQVFVYDIQERPWVATNIWTAHPDNPIQSLVMDPYSIEQAGRYTCWSFARDSLRAWDGLLSVDWIDKQLRIRQPEFCTFRQANILICTWNIDSCRPADLANGPEPNQRWLDECLKSVDSPDIIVFGFQEVIPLTDKKITAKTLLFGSKKDTGATADRVSHAYRQWLEKLTSAVLQAMPAGTPYVKIHSESLVGLFTCIFVKSKEKQMLRDLDITTVKRGMGGIYGNKGAIVSRLVMDDTSICFINVHLAAGQSQKASRNADLAGILEDKAIFPPTEELPFIHGGSGTGILDHEMVFLNGDLNYRIDQRRENVISSVHSNELAYLLEHDQLRKEMRTNHAFRLRSFEEPPINFKPTYKYNPGTHDYDTSEKRRIPAWCDRILHNKSPRITPINYQRYEPVVSDHRPVSAGFAIQLKMVDQLRMLEVRRDVTAEWGEREKEILQQIRDIFEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWL3</accession>
    <name>A0A1E3IWL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030225.1">
        <property type="nucleotide sequence ID" value="XM_019177841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWL3"/>
    <dbReference type="GeneID" id="30194975"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="520" mass="55841" checksum="42144212E61E68E3" modified="2017-01-18" version="1">MPEDQEGNSGGDRGEYHTTPPDLSYTDTPGQERIQERRPVPHSSDEDEASLDQPQNTPHPVSDYMSDFNRQLGQGRTTGSNRRGEWPTPIDPFAGIDSYIAASVDSQGLTATAGGPSAHDLPPLLSPTLPQTVEDLLEEARTLGEDANRSSAAAIAPSERLSVSRTAHRRAGSDIRWRPSQPIPIRLKSKPKMEQSSDRQELLQNAVLFLNDPKVQSSSLISRIQFLESKGLTEPEIQQALNQAAGEPSIQAAGLGIGSGSGNAPPERPRDPAPRYGYQQAYAVAPEPPGRDWRDLFIMAMVTGGVVYGITALARKYLVPHLRPPSTTAFQETSTSLTSQYDEATRLLGELQSETTKLQTNIEADRERVDTVVGDVEDALQSLRDGEERWRGEMRDIRGEVESVRELMIEKHAQSQSTALADLQSEIRSLKTLLASRQAAISSPSGSNGNLPSHSGAGRNVSTPTTHAANALLGPRAGRASIPAWQMAPTSSASAGGASSPGGRASPAKEETDKEAVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXT6</accession>
    <name>A0A1E3IXT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030514.1">
        <property type="nucleotide sequence ID" value="XM_019177361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXT6"/>
    <dbReference type="GeneID" id="30194486"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="953" mass="102744" checksum="DEE4FFBB50DC4D97" modified="2017-01-18" version="1">MKAPTQKNNKRASYSPYPPADDKPIKPPPLPRTQSVASSSRASQPPTPSAASDAQSYKVARAISSCTRCRTRKQKCDGKLPACTSCDRAGVECIGFDAISKTNISRNYLHQLEEEVAVLRAQISALSSVDPIGERKRNIAANSSHAVSNYFPEFPGENGPSRDGRSPRSPFASPVLPSNNGHQQRRYSDFPYPSTPISADPPRSPFTSSRPHPTGQPASLHATSLTRMVHDAALRTGHAANSGITSGSNASGSDRGSTHGGTIDSPMSAELYDHHISLETLPTPTSAIPRLPPSASGPVTLSVSSGGKPRRKVTIPPLPPQGAVEKLVAAYVDFVGVTGPIIHIPTLGRQLSNIRGGLDVEESDIFVVMMVLALSTMASSRFVDPPDDLRACSEAFHAEAIKHLDAVFEGQSYVGLQAILLLVWYSLLNPDKGSIWFLIGLATRTCVDMGYHNEHNIPVDQLDALELDMRRRLFWCTYKMDRLLSQSLGRPPSIPDGFINVPLPSDLHDIDIHSGHYGPMTGEPCSYKAVFIHTTKLRQLQSEVLFNTYGVHSSTGRLPSQEWVDDCYERLQDWLKNAPEPRGAVSTEGYALSYHNSCLLLFRPSPGCPRPGRKALSIVLSSSGYNIRIYRRMQLNNRISWLWMTSHFSFMAGLSFLYAFSNLYSLGGGEDVPTIEDAMMTIESCLGVLEFLAPRVPSASACHDTMRTLSQAIFKQLGEFNPPPVSNTSGSPAQRTNFRSVPISSSREDPLPNEVFPAPLPPVTMPYEMSLLDNLFRNPMASHNKASDYTSNKQCGKRAHVGVDGYSHAPGGMPPRAFHSAENGHHAPYTPTSTNGVSSSIGDPNTLMGTFGMAAHINMSPVATSPVFPASDGPSLNTLANTAAAAAASAGSQSTDERISAIIHGRPNNGTGNGTAFGENDGAFDVFSFLMDEEGGLGSNGYSEVPADFSLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW2</accession>
    <name>A0A1E3IXW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030483.1">
        <property type="nucleotide sequence ID" value="XM_019177330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW2"/>
    <dbReference type="GeneID" id="30194452"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="63" mass="7605" checksum="35DB50E7B68F45C8" modified="2017-01-18" version="1" fragment="single">GMAADDEMERLQKNAEEHIQHRHDEMMLVEKEKMKAEKERMKAEKERVEIEKKKAEQQCRPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW6</accession>
    <name>A0A1E3IXW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030544.1">
        <property type="nucleotide sequence ID" value="XM_019177391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW6"/>
    <dbReference type="GeneID" id="30194517"/>
    <dbReference type="OrthoDB" id="4510058at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130085" evidence="2">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="28449" checksum="FA5FEEBAAE6AD3C5" modified="2017-01-18" version="1">MPSSTLCLAVLAILSSASALNTFRAPADIVVVVRQDDDVAHGDSFDGDAWKAESGLLGPQEIDRRFDFGGFASSVKDQATSFATGVKSQATDAASSFKSAGTSVASDVKSDATSAASDFQSAGTDIASSVKSAATSGASYVQSAATSGASDIQSAATSGASDVKSDATSAASDFQSAGTAIASSFQSAGTAFASSVVSGVNAVRGDSSSVTSSAESIGSEIQSLATSAASQAVSVATSAASSAQLGAQSLASSVSSGSGFASPSSAASISRGVQAGTMGLVMSVGAAVVGAGYVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW9</accession>
    <name>A0A1E3IXW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030549.1">
        <property type="nucleotide sequence ID" value="XM_019177396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW9"/>
    <dbReference type="GeneID" id="30194522"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130019" description="Carboxylesterase type B domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="71"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN93444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="620" mass="65346" checksum="98976B1154DE1D4D" modified="2017-01-18" version="1">MLLLTALLLFSNLLAAHPFPVNRPTSSGCTYTAYGHTATGYETSDGACRYTIKYGIAERWAESVAPHQNYASEPPSCPQNSGTYTVGSSQSEDCLYATVYVPKSTAPSAGWPVFVWIHGGSFVQGSTSAPGLDGSLLAKNGNMIVIMLQYRLGVFGLLPPTLASTSSDPSLGLKDVILGLKGVNQYIDYVGGNRGQITVGGQSSGASMIRALWGAPAASGLFRAAILQSDPMSFGFASSDITTQIQSTFYAMSPMSSCTTLDCLKNISASALVTAQDTLISTVPYTITGVPFSEPLRPTYNTTALPSDPSSTLTNSPSSLTFTPASLPILLTTVKNEGGTAISSIFSTHVPLSNDTYYSTASALIGTSRATSLVSSEYYSLPAINSTSSTAPYGPSGDTFRETFERAVTDGIWKCANVDVANKWASAGGKVWVGEWREGVTYPDNESGYCTGDGIVCHEDDIYPTFGTASDPSSNTSTLESTIFSHWVAFITTLNPNPSSAAKKRSFSFTWSSWWDWSWNGQKAGGSSDFALSPGSSSSHSSSSRSSLHSSSSHAYSSSSSPSPTSTSPSSSATSTATSKWSQYTSESDVFALGGDEQLSGACPAGFWGDSVPFDWQLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY16</accession>
    <name>A0A1E3IY16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030423.1">
        <property type="nucleotide sequence ID" value="XM_019177672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY16"/>
    <dbReference type="GeneID" id="30194804"/>
    <dbReference type="OrthoDB" id="2568121at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="118" mass="12993" checksum="467F56B7A43AD58B" modified="2017-01-18" version="1">MPSRTLVPRITPLMRHTVTHPPVIIHTTGAAAAAAPHYEHSFENDTEFSPWWFANSAPVPSVHPNQTTTAVSHGPPSPTPILTPSAPNQQPTLNQDPAKKSHYTPPPYTWVDYRLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYB3</accession>
    <name>A0A1E3IYB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030689.1">
        <property type="nucleotide sequence ID" value="XM_019177536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYB3"/>
    <dbReference type="GeneID" id="30194666"/>
    <dbReference type="OrthoDB" id="10542670at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="23417" checksum="B32DC128731957B9" modified="2017-01-18" version="1">MNSSWPSTAPKSSSCVSLSFLPAVPHLIPPPANTPSSPGLATIFGLFLLAAILFAIYASRRAHNETREAGVAVLGRWKENRGMEVPPVPKVPGRAKGSGSGSDRASDAEKGQAGGVKDEKAQMSVGRRLSGLAGIGARGLGVGRGSYEPVPPPPAAGRDTGYSKSAQGPKPPSKDRVPAASKTRTPRSPARSAERIDSRESGKGFWREGEGQKVKVEKRAAGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J065</accession>
    <name>A0A1E3J065_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030798.1">
        <property type="nucleotide sequence ID" value="XM_019177217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J065"/>
    <dbReference type="GeneID" id="30194336"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="23608" checksum="1B1EFDFCC878E25F" modified="2017-01-18" version="1">MSTTDALTYDDGPLVDCEMTGLDFLNDKIIEIAVIITDGRLKPVDEGVSYIINTSKEVLDGMGEWCTEQHGKTGLTRACLDSPHSYEDVVQKVLAYIQKWIPEKGAGLLAGSSVHADMRFMLIGMPEIMQHLSYRILDVSTVKEVCRRWYPTVRAKEQKGRAGEIAHRALDDIQASIKELEYYREHIFIPVESPVDAPKDEPVEVRKTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0J4</accession>
    <name>A0A1E3J0J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030869.1">
        <property type="nucleotide sequence ID" value="XM_019177288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0J4"/>
    <dbReference type="GeneID" id="30194408"/>
    <dbReference type="OrthoDB" id="10418985at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1089" mass="117509" checksum="302E30DE536F98FA" modified="2017-01-18" version="1">MPSSNLEDIQASSDKIKSQLAKDRTLPGQKRLLKWTKGRKLVDESLQAGDLLPSEKTLELAEWIEDDLSSTTAAVSASLKLLWSHSIMGQVLSATDTVDCSKTKPQACLLVAEDARGPLGLLKRTERLLTGLTSFILTEDLLDARGQPAELANVTQLLCSVLELVAEGRFAGPLLHLYIGELLLQLSDNDECRQLLTDQKTLGFTKLGQLLFTSQSSTLSSSLLRLIHRLLPEHIKGSGKASARTKCCKDVIVKQGWSIEVAKEGLVAIGRMEKDLVPRHLAKLINIFSKESSLVRPVAFTLTSMSIDGDDQAAEDDASQAFDKGNMLLYIDSWGWRFELGGKLGSDVCSSHSHQDVRSVNISTNDKGSATHELIATSLLGDTTTIKFTSPSAALNPHLDLGAPRRISTPDPAETPSAAVEDLVKPYPKSEKIIAPAKKVEEMKRKQRFSSMGGARGGTTITSDAEDVFSSVEDDPKPKRNSVTPAACFSGGEKDAHDVRVKVEEQVEPKKEKVPVPFKSEEQEDSESEDELFVNRRFISSTPKNAIAKTYGSKPSSRRPMLVKSPILDDPSPKSFAITATPHKRAPKATKSTKKSSTLPTLTPGGKKESQQTKRLKTKSSTLAGEIKIGREATPGSLRDESVESHTDKPVGRTQKKSKAKSTVVSEKSKKAASSSVDTEHDDGDSSSEDEKSPSIPTARPETLQSAGTDEVSPSAVKAGMVKGKNAKTKVAAPEESESEAEAPLAKTRRSKSSVKLQTADPPASESEAAAPSVSPNPRRSRKRIPKDYPRADPDEGSSSDIGDVLPPTKRRIESSDEEAEAPPRKGKKVREEVVYDPTMEEGNKSVEDESSTLEPKTKQRAKITLDKKPRPRASTTSKADATVPSVAEKTRRSSRRKTKPMAALQSGIPKNHTDNSFEDLDAEEENHPATTIKASASDAETARAVAPRESIKSSAVTKRSSKSSPKRKRIPSSSPESSDSVPDSGFELDPIESSATSSDDGSEEPLPKVAKVKTGSVKKGIVKNGGTKEVEKKNGAKENLDKDRSATVNTTGKKKKGGEKQEFSGSKMAKEFSAALKKNAGNTRARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0M7</accession>
    <name>A0A1E3J0M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030736.1">
        <property type="nucleotide sequence ID" value="XM_019177155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0M7"/>
    <dbReference type="GeneID" id="30194270"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="237"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="569" mass="60951" checksum="3AE6B128FEF6152A" modified="2017-01-18" version="1">MASLKDTHPENVEAHDLLSIDHAVCFDNEEGTLAKGQFRLQCVSLPIPKEIGRQTANPFAPSPSDPPIPTHDYWLIIQVGASFELLATPGQLFTPQVTKDSITYTITSRDIPGASIAFILPYPQTNAQLEDLESLELLLHHYKSMGAEATALAGIEPQNLTGSALAPEELRGKLVLVNNDNGEVLGEMDENLDIEVDKRIAKENENLPVVLDFEQVMEGHQALRVKVKTVPEGDMDDWLLRGANSISRGILTFGAWSSRQMMSGADQFVKGSTPREKPVVFSPQTKEGFMKVHKASVTTATVTKSTLNKIHGAIQTVAGKTYTHGVQPVMSTYQENYRELAGPPLPPRKQPQQVAASSASQKGAPSIPDKPLELGGAQVPYAARQSPSPTKGNQLAYPASTQAATGQLEKPPNYSVDPSASRLPSDVVPDQPKKKRGLLSRVVLAGEVVFTSLEATAHDIINNGTIAASTAAGHKYGRDAGEATALVGGSIKNVAVVYVDIAGVGRRALLKSTAKGVIKTRTNDGEIVELRAEGNGNQIRAGEAERVDEGEIVVGMTEVKEISPIVQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4D8</accession>
    <name>A0A1E3J4D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031377.1">
        <property type="nucleotide sequence ID" value="XM_019176449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4D8"/>
    <dbReference type="GeneID" id="30193543"/>
    <dbReference type="OrthoDB" id="2574942at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="10446" checksum="E64C028CE5E2E967" modified="2017-01-18" version="1">MSAPTSSSSNTVQPSISSPGETPPPSIVAAGTFVPAAPVEPAEPQQEQTPATGPGSGGVVPDQAHKLPFKEQVNGYAKKFAGATFGNEQEKEWGEKKLAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4G6</accession>
    <name>A0A1E3J4G6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031130.1">
        <property type="nucleotide sequence ID" value="XM_019177098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4G6"/>
    <dbReference type="GeneID" id="30194212"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130192" evidence="8">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="29559" checksum="3733D0AE72134C11" modified="2017-01-18" version="1">MRPLLPLLASLSLAAAFDCALSPGSIPFDLHPLAGIRTASKQSDTPPTTSEAKVSLDLCNPEGLQREEGLSDEDQCPPKTKVCVKLLNHKPSSSDPDRVTAVIPFWSEDMPAEDVTTTPLGRRGDQGLKIDVNGPEYAGVRQYLNLTLICDTSSSDPNPTLISYTSGNLNLEWATPDACPKTADSPSASEPGEGGGGFLSFLATLFWLVLLGLVLYFAIGIFYNHQQYSARGWDLVPHRDFWRDVPTLFSDLFSHVASGLRGSSSGGGRGGYSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J541</accession>
    <name>A0A1E3J541_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031216.1">
        <property type="nucleotide sequence ID" value="XM_019176741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J541"/>
    <dbReference type="GeneID" id="30193837"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="756" mass="82757" checksum="50C0584735CD0E7D" modified="2017-01-18" version="1">MALLYSLRMALYSLLLLTTSFIAVLIGVLCTLTRQRLNTNYYVARTFWHIAGPIIGWKFDVEGEDYLWSLSESEGGGKAGKEGRSMVMVGNHQSMVDILYLGRIFPKHAAIMAKESIKWIPGLGWFMLMSGTVFINRKNNKSAASIWIFPEGTRHNVPDPDLLNFKKGAFYLAVEAKVPIVPVVCENYNRLMDGETRFKRGTLRIKVLPPIPTTGLTSADVPALMTRTRELMLQTLKEISIPAPPSSSTGSSAASPTPLLGRPEQDREGHYGTGSPADPVGGEEDGEDAEDAVEDAVGEEEASKGERVVPLEDQKPNGGVAKRSKGGKKLAIAMVSDFFLPVVGGVETHIYMLSAELIKRGHKVIVITHSHPNRIGIHLLPPALKVFHTPIPPVTASQATQPNYLHLLPFFRSICISEGIDLVHGHGAMSSLGIEAILHAPLMGLKTCYTDHSLFGFQDWPGIVSNQLLVGGLRNVDQVICVSNTGRENMVLRAQLDPALISVVPNAIVPEQFKPDPSKADPDRITIVTIARLVHRKGIDLLISSCPSICALFPKAHFLIGGDGPKMVELLQMVEKHQLQSRVTLLGRVLPGEVEGVLRRGQIFLGTSLTEAFGISLIEAASCGLFVVGTKVGGVPEVLPNDMIEFCRADEDDVIRALTHAIKIISSPNRPDPFESHRRLAQMYSWSDVALRTEQVYYRAMARPERDVGERLARFLTVGPVYGPVMCCIAAVSAAWFSILAFWNPKARLERKTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J698</accession>
    <name>A0A1E3J698_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031636.1">
        <property type="nucleotide sequence ID" value="XM_019176226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J698"/>
    <dbReference type="GeneID" id="30193317"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN96390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="864" mass="93499" checksum="E1C0106EF93A5145" modified="2017-01-18" version="1">MNAAQLLQDSLSANQSARESATQQLEAAARDNFLGYLHTLATELANESQSIDVRYAAGLAFKNGIAARDIVNQAALTERWLSLPDSATEPLKHLTLSTLGSPQQRAGAVAAQCVSAMAAIELEVGKWTDLIPQLLEFVQNQENTGLRVSTLQAVGYICEVIQPQILAARSNEILTAVVQGARKEEPSADVQHAAIQALYNSLEFIRDNFEREGERNYIMQVVCEATQSPSVSVQVGAFECLVQIMHLYYEKMDFYMERALFGLTIMGMKHSEERVALQAIEFWSTVCEEEIDLTAAAQEAIQYGDRPEVESKGFAKAALNDILPVLLGLLSEQDEDDDEDDWTKAMAAAACLQLLAQNIGDDIVGPVVPFVEAGITQPEWQRREAAVMAFGSILDGPDPTTLGPLVTQALGALIGMMQSDPSLPVRDTVAWTLSKVTETMLEIIDPSMHLRDLITALVMGLTASPRTCNSCCAALNNLILQISSLPELPEDSPTNLMSEYYSGILKELMPIAERPHNQSNSRSAAVQTISTFLSSSANDTLPVVQEVAVAFIARQEALQGVHNQLVGMDDRNNWNDMQINNCVVLSSFIRRSPAAAAPFADRIMTNLISLISTSGKQSGVLEEAFATIGALAGALEAGFNKYMDAFGPYVITALNSYEDHSVAQAGVFVTSDIARAVNEALQPYAENIMGALIELLRSPVVARHVKPFAISAIGDVAIAIGTEFKPYLEATMTILGQAGSTTAPAGDEGMIDFVQNMRESIVDAFIGIMNGFRDTEANVILPYVGGILGFLQTCWADEDRSEGFCTSSLGLIGDFASVFKTQVSDDITKVWVQEAISAGRNRSASKQSKTNAAYAQHALKELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6K5</accession>
    <name>A0A1E3J6K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031391.1">
        <property type="nucleotide sequence ID" value="XM_019176463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6K5"/>
    <dbReference type="GeneID" id="30193557"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="21739" checksum="0157970CEC96B07A" modified="2017-01-18" version="1">MMERPPQEFLYLAATLLDALPASEPISDALLLQLHMLFGPMLMSALQLVDRREVVRVEYPSSRHVYQVASSTGKSYTLYMDPPSATVPCTRESSLELAVPKDDPPVHSSMPEESREEPPLAPNDRLTSAASVEDTLKEEAEAGRRDRIRQLAVDLEGYYCPCAGYGHNTLGSGRTVVCKHLLAVLIGSKTGRVVASAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N0</accession>
    <name>A0A1E3J6N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031754.1">
        <property type="nucleotide sequence ID" value="XM_019176344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N0"/>
    <dbReference type="GeneID" id="30193435"/>
    <dbReference type="OrthoDB" id="2577920at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="234" mass="25939" checksum="632AF5E36DA72B7C" modified="2017-01-18" version="1">MVAAVPNTWSQGQGTAFIRNIDDSDRPGVKLFHSIVDTIEGENPLTIISWVAPDSNHELEDLFYFSGDVAHDGNAASTLFVHSASEAHINTLPPTDPMYETLLPPIVWYIQCLGIVGNADESSRSFEVTGTTYMGKKGDWAAFVWRVEVPDTARWPYWPYKDGQHVFVSGPLEKRVDGVYCINLQSMHSVGNFSSSAPSSSPQRPTVVHRRPNIAFSHEHPVKSSSVPTKKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6V5</accession>
    <name>A0A1E3J6V5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04303</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031833.1">
        <property type="nucleotide sequence ID" value="XM_019176423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6V5"/>
    <dbReference type="GeneID" id="30193516"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130160" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="30"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="817"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN96587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110754" checksum="1A61CB1939CCE104" modified="2017-01-18" version="1">MLIKAKGSPLISSLLTAFLFVAALPAALALQDNLAGIVDWHKPYIGQPLLTPTPPLYIERTNFSGGRVALITKNNVLAAINAENGDIAWRQKLEDNDPVVSFHVQDDTILLLSGPSASSARLFSLSTGHLLWHYPLLPPATSQLSTPVHLGTDAAFVPQQEDGAPATWVILSDGRRVTRLRHDNGQIFWSMDSPSAGSNMVFKQIRPSGNSIHILALHYSFAVQSLLTSTIALDSPIPRGDFGQVPSIVQIPEQAMIASSAEPGGAQVVWFEHGRIRSLLVHEDGSLGQIKDLLPGNGRHYASIIDVGLREQGIVLGKREDGGVEVLDVKEGKKIEEFELSADAAERSESVYSGTVTENGVIVNRVYWSFSMSIAVAQTIDIPYLTSTDVITSGFTFPYDDLSHGVLLHAAVSPSLDAKHLPSLVLTTSASAILRSQFDSLPLWVREEALADVVAAKFVDLGEPEVEEVREILGEESFVGRSVRHLEALKDLPGYLINFAKRLTGASYSSALHLTPLNKNRLHRDQFGLQKLLVVGTANGKLVALDSSNGQSVWSVNVGLITKEGSEIQVETVDLVKEGETDSPILGVVATQFTKTRSFTVAFHVEAYTGKVLGDVHPTTGLPKGTYLFEGVVKEVFATIYKNCGSGIRVLGLVNEKDEVSIWPGCKTVVGQIAEGGKPFYTTISTNLDGAVLKGYVLAGPKAPESTSAFTSTLLWSRPFTEHERIIDSKPLQPSAIASFGRVLGDKSTLYKYLNPHLLVVSTFTPSSPKALNPLQAGEPVGQGKVYVVDSVSGEVVYETAIEGVKERGGVKVAMVENWLVYSWLSEGGWRIASVEIYEDADKGVTSPALSTFEAHKIQVFAQTFIIPTAIKTLGFTTSKAGITPKELIIINDRNQITSVARRLLDPRRPVGKPSSRDKEEFLISYDPLIPIDTRKVISHVYPLQGITNILSSPALVESTGLVFGWGQDLFLTRGLTPAGTFDILSDSFNKAQLLLTLGALSAGIMVARPAVMRKMLRMRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Z7</accession>
    <name>A0A1E3J6Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_04169</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031701.1">
        <property type="nucleotide sequence ID" value="XM_019176291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Z7"/>
    <dbReference type="GeneID" id="30193382"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN96455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="984" mass="110271" checksum="E26044714B032777" modified="2017-01-18" version="1">MLLRELQGDPPHATSDLEDAQESQSRPSSHILELEGQGSGSTTRGSLSRRSPTHILDDGSDDDDGGNPPQSLIFGDQGVQRARDHRDLSRATEVTDTRKGGPMPLSEAYSDSRDHPLPSSSSKQHLARPRSTGPFVEASGSSRSTSIGEGAEPLSICASGSDVKASSMGVPHIGLPASGRETQRPLFREVTLPQPSSPQRPSWPGSPSQRVNGYLDPNIPPPLTSKSKGKGKERVRNKGGRRYHSVGTEDLEDGNRRKTPKSGLDEYEKALWKWVNVDDLDGFLQEVYEYYKGKGIYCIALSRVLNLLTTFFVIAFSTFLISCIDYSKLASGDDTVNRLDDVLVGQCLRRGSFTHMLFIVILSAFFIFQAVSFALSLPRLLEMYRFYTHLLRIPDADIQTLPWPEIVRLVGEIRKHNPITSISNGQASALADMIGDNTTGAVKKLDAHDVANRILRQENYLIALFNKDLLDLKVRIPYLSFGANHLTKALEWNLRFCLLGYLFDWRGQVRKDFVREKRRQDLVQGLRRRLVFMGILNGLFAPFIIVYLLMYSFFRYFEEYHKNPSSIGSRQYTPYAQWKFREFNELPHLFERRLDRSYVTAKEYVDQFPKEKTALVMRFVAFVAGSFAAVLLAATLLNPDLFLHFEITPRRTVLFFLGVFGSVLAVARSMVPEENMVFDPEASLKEVVKWTHYLPEEWRGRLHSEKAKFGKLFALKITIFFDELLSVILTPFILFFSLPPCASEIIDFFREFTVHVDGVGYVCSFAVFDFSRQGNVDLEAEDLHRPERGADRMGHQAQNTIPSAPLSPRLSNRGLGNRTRDRSSNEIKMEKSFLHFRATHPDWQPSDPNSSVFLDKLAHIRNRHLSPGAVAPMGAGPGGSFYAGGRGLGIDGSVMGDMNEAQLRAKSQAYERAWTRSSNLHQQTVLSPSNVRGRAIEEGDEGGDSIEGWTQGHQALNGSVEAEEGASPWRDEGVVGMLQQVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8S5</accession>
    <name>A0A1E3J8S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031875.1">
        <property type="nucleotide sequence ID" value="XM_019175962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8S5"/>
    <dbReference type="GeneID" id="30193049"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15116" checksum="2E89E996E6253DBF" modified="2017-01-18" version="1">MVGADMEARGTARADCLQAANSQGIQTLLEAEKEASKVVQKARQYRVQKLKDARSEAAKEIEAYKAKKEEEFNKFESDHTSQTTSSQTNIDSTTKTQLTNLDSSVEKNKGEVIKKIVGRVLQSDPHLHPNLKKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8U7</accession>
    <name>A0A1E3J8U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial import inner membrane translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031752.1">
        <property type="nucleotide sequence ID" value="XM_019176342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8U7"/>
    <dbReference type="GeneID" id="30193433"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="244" mass="25330" checksum="06A5F73F9392D068" modified="2017-01-18" version="1">MAIFGLFGSSTPEQQEPSASADLFSSTNFRSNVIPSEQPQQSSSFLPDPPSQPNATPPPPASQQHAPTALEALGSAFDPARLHPLAGISENLDFLQLDEEKLNELEGSASVLPSRGWTDDLCVGTGTTYVSGLAAGGLWGFKDGLSRPLGNNPSFKLRLNSILNGCTRRGSFMGNSLGVLAIFYNLTNSSLDAVRGKHDVFNAVAAASVSGAIFKSTAGLRPAMVGAGIGGIAASAWSGFKSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8W3</accession>
    <name>A0A1E3J8W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031607.1">
        <property type="nucleotide sequence ID" value="XM_019176197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8W3"/>
    <dbReference type="GeneID" id="30193288"/>
    <dbReference type="OrthoDB" id="2570167at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="35245" checksum="1051267FD1C87A92" modified="2017-01-18" version="1">MTWWKKFVVARGDNTQEKRRWMRMENQETSAVDQNDPPQSPSPRIKPESTSDPESQSFLPGPQIARKMLVAWRIGIMVPFLVAGCLLYLLTCSAPSWRADWSVVRLDLAQTDFDVLYDIAETVTGRKSDSAQSKRLLPKSSFVAARSAVVARDDEANEDLGVLSINMWGWCLKPESDTDGTTICSSESMWFNMDDLLGAATTTQAGLYTHTFSAILIHALIVHGLAMLAAMTAIIPIGLTTWRVFRSKNPTLQGGWFEHVSILFASLLCLVAWIIDRCLQANVSSKLSDTDVKAGYVSRLVVLFEMTNLLRAGWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B6</accession>
    <name>A0A1E3J9B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_03828</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031867.1">
        <property type="nucleotide sequence ID" value="XM_019175954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9B6"/>
    <dbReference type="GeneID" id="30193041"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000104">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN97265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="317" mass="36134" checksum="B83AA14700E47CA7" modified="2017-01-18" version="1">MAGAVPQFMVDEYVLAYHGPLLYEARVLLAESWDESNTLSGQVGPHYFIHYKGWKQTWDEWVPESRLLKLNEAGFAKRRALLEAQAKKGRSSISSAAGTAGGGGSGTASPGIGAAGRKPLKDFKKDGKKRGRDALDSETDFMKRPEVKIVIPDILKLVLVDDWENVTKNNQLVALPRKPNVRELLEEYRQYASASKKQERSARATALLSEIISGITLYFDKALGNNLLYRFERAQYVEQKRQNPEKPMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILRDYINDIMDWMIKDQKRLFMKEYEETTTHYQNLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9D1</accession>
    <name>A0A1E3J9D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032059.1">
        <property type="nucleotide sequence ID" value="XM_019176146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9D1"/>
    <dbReference type="GeneID" id="30193234"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1230" mass="136707" checksum="4017B5D1233806FB" modified="2017-01-18" version="1">MSWRSPKRLPFLAPIDTRDGIPLQHRGHQRVPSRASAEYDYDAEAQNSQRSIPKGAPGLARKKTLVKPEREVVDPNHRLRHYREHAVEDHMDIQASATGNRPAPVTFSNSLQRGKSLLIRELAENHNADYIPKEGKDHPPLCCLGDIAPGPKDCWMIYCYIITLWIPVFVIRKVFKRVDAEGIRAFREKMGIVAILSSLMAIVGFVTFGFTQTVCGDNALRISGGQANLGSLVINGYDYDFSTWRHPEAGSLFNGSTSPLWMDQYNAGGMDASFLFQKVNQHCLGIITPAEGTRITTNGDNMGWYFACNLHDQNDTSVANTTNYGSDYNCHPSQKARDAFDAVVPTAKIFYTWDRVADTEVNLAAYKSSILDFNLLRGLDSSQVKYPTLFDTLKNRNASWAGKDISALVERANATEYADCLADIIQVGYVDSMTIGCFISNMVLYVSLIFILGAVLIKFFMAVTFGWFLSWRLGNLYGIKYQDRIQRAKEIESWTEDMPTHAPEHLMPDAPVEGKQPQKKVEKRRLLALPTKSRFSQYSMPRGNLPSRPSTMMSQRQSFYSAASRPVTASDLAGVVVGGSHKVSGSQPSSPIVASSTPSAAGFGNDPNDSSLKVPSGATLRESTSFASLMSNPDARLPLSPHVIAQPEADDEPYGYPLIHSICLVTAYSESIDGLRQTLDSLATTDYPNSHKVILVIADGMVRGSKSDKEKAADEAAGIPEQEVDYTPNLVLSMMKDLVQPADEVVAQSCVAIADGQKQHNLCKVFSGFYDYGADSQVEDTKQQRVPMVLVVKVGNPSEAGTSKAGNRGKRDSQVLLMKFLQRVMFHERMTAFEYEFFNSLWRVTGVTPDMYETALCVDADTVVFPDSLQRMNACMVNDLNIMGLCGETKIANKAETWVTMIQVFEYYISHHLTKAFESVFGGVTCLPGCFSMYRIKTPKGDEGYWVPVLANPDICEHYSENVVNTLHKKNLLLLGEDRYLSTLMLKTFPKRKMIFCPQAVCKTQVPAEFGVLLSQRRRWINSTVHNLFELAQVRDLCGTFCFSMQFVVFMDLVGTLVLPAAISFTMYIIIVSIIPQDKTGIPRPIISLVLLAFILGLPGLLIVITSRKVAYVGWMLLYLLSLPIWNLVLPAYAYWHMDDFSWGATRVVAGEGKGDDKHGEKEGEFDASVIVMKKWEEFEADRRWAVLEEAKLASLSLPVSPVGSSRSGHQPFDPSRDLLNIGRLGEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBL9</accession>
    <name>A0A1E3JBL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032109.1">
        <property type="nucleotide sequence ID" value="XM_019175619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBL9"/>
    <dbReference type="GeneID" id="30192702"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39752" checksum="76377FC6672DBBDD" modified="2017-01-18" version="1">MSPSSPLIAITGINGFIATEVVLLFLSHGWHVRGSVRTTAQADKLKIHPAYEKHFASGKLEVVVVEDLAKADFSELLEGADAVASVAAPLPKMDNPSLTWDKDFKGPTIDPVLRILEYAKKSTTIKSVALMSSSGSCFDLTPPPGKVYTEADWTPYTEELCQSITPATNPAASIIWYFTAKKLAEQAALKFQETEKPVFSIATFAPAMVYGPPQFIPSIDALKGVQGTSDEFLGLFFGKDQPLPPQFARAYADVRDIADAFYAAITKTVSGKFLLAGHEYKWQALADKLRELRPDLDAYFPLGTPGQYIPDEYFADSSKSQRELGIQYRTTEETLKDTIDFYENLGLFKEAPLGPRKKAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBR0</accession>
    <name>A0A1E3JBR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YTH domain family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032151.1">
        <property type="nucleotide sequence ID" value="XM_019175661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBR0"/>
    <dbReference type="GeneID" id="30192745"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="637"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="849" mass="90122" checksum="32B9FD479E6E6EF8" modified="2017-01-18" version="1">MSSAPVAPIRQPRGPSHHSFSSTSPPAPPTGNSPTPPGGNTASGPPAADQDSLKRANTVSNPRHHQASASISANPAASSAFHGPAVSTNSVSSGNTTGSGGRSRVNRFRSGSLSAALPDPGLVRRGSGREVRKEVVLESQVEGENHEMGGQQWNKGLSRQSSLPSRRGLNPVQQPDQPLPSRPSRRLAVNTAGQITGPTPPQSAHGASHSLSSLSMLSQPQYNNQGLDEPINAGVGGNGGGAGVSRTQSLRAQAKHISSGNLGRSTSLKAVGEHTYRPSMSNINPDSQPTPPNVLSPQNAFSPPTPPPLSSTAALPPFGLPGYDSAIATGPADVKRHQSLNQGYGSHSRVRDRLEKSPAVVSLEGRGNEVRQRLDSGRLDEDEPPTSPVGPSVWSNNPRLGDGWASAPGQANSTKNASQQLQDAFEAMNLGRKMMAPENGFAQGPLINGGYGLNRERLNLETNIMRHSHAGSPASGQLQRKGSGADGEPSWVNKLVGGDNTPMLGHNMPRSASTHSWGGERDRNDQGYSGYPGNYMNFNNNGYMPMPQNHQGRMMPPMPMPGMNYMGMPGYAQGFSGYIPNGQQLGGPGNGHGGQGQHAYPSPPASAGMGAQDKDVIELARKKGLNPATFECRPQGARFFVIKSYTEEDVQKSLKHEIWSSTVLGNKRLDAAYRENAGKGPIYLAFSVNGSRHFCGVAEMTTPVDETKTSKVWAQDKWKGIFEVKWIFVRDVPSAALRHIRLTNTPECKPITNSRDTQELPYEAGSEVLQIFLDHQTKSKTSLLQDFAYYEQLSANRQGPSPNGNAAQLNQIQTPVSAGGHQPPQLAPAMGISNGASVPPVPTIPDRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEL0</accession>
    <name>A0A1E3JEL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032203.1">
        <property type="nucleotide sequence ID" value="XM_019175713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEL0"/>
    <dbReference type="GeneID" id="30192798"/>
    <dbReference type="OrthoDB" id="2586076at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="763" mass="82944" checksum="448574A73F5FA037" modified="2017-01-18" version="1">MASLLPSFRNSSASNTSPRSPSPPSSSHELSPELRTSADAPRLSPFASPAGLLIPWISESPTYSSPQPRSARSRSRSRGAILGSITMAGATGFIDESHPHLVGRSQEGPAEPMDIPASRVNEPSVGPSRSIPGCSSRVANVPEQSPIPTYETALSQSLTSPVHDVVSQPVSQSWTEDLNWARDYSVSANGGRQRQDIDDYFGLAPDEGEEEEESPVRGRSGYRNPHGDSAEATGRAPMPPAYSPEVGRDELQIVSSAHLSPDHPASGFFDAIATSPDGADPPPAVSPNDPGLTVGNKKLSVRIEEGSARRWNQNSTGPIYIKAGRKGKVKGTVYVGPVDHAHKLEVSILGFAKTSFYVRGQFSMIDTLPLVRSSLILFPPARDSQDDSLKRAKDGTLLMEGNSVFPFEVEMPSAYWKDQTSELPPTCNIQQSGLQASVEYVIRIKLARKGQLRTNEEIGIPVIYEPRSYIPPRRLRLLAIADDRHNPGWRTIDLKGGNPVCPESLSAPISATLTLPSPFILFITPNQKLPTIPFHIHFHHPSGGLPLKVFSDPRESDWVIRLQRRVDVKVGGEKEVRYTELTCKVEVWEEGGEVIDLNALRKKKATEGSKPRRPSEDAESSANAQSKTESPRKKSLSLTDRLRRMSSTPAVATLSNSPTGISSIEEHPPVPSAPSSSNHEAVLGDGVQAHLATDITVHGRLDVQLPTTIATSDSMRKMVQSFNTPDFTVLYMMTVGIQPKKGAVKENFGFMYGRAMVEVVWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF22</accession>
    <name>A0A1E3JF22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032557.1">
        <property type="nucleotide sequence ID" value="XM_019175454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF22"/>
    <dbReference type="GeneID" id="30192537"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="24852" checksum="6C55368072FBDF3E" modified="2017-01-18" version="1">MLSRSALRLSARLASRRAAVAPQFVARRAASTSAGGHKASSDLPWIAGSLVGFGGLTAFILVPSKQTVHHAVTPHDDEKAETNESAPKASTGDDPVESPNTTERAVASEDPKDTHPNAEHSAEDMTTKKEGKGEKPSEETKPSAKDGGANANETAQVQKAAEDEEKKDEPKEEKKEAESVEQATKSDAPAEAKEAEEKDDSLAEKKSVEQATKSDAPAEAKEAEEKGDSPAEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF46</accession>
    <name>A0A1E3JF46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032541.1">
        <property type="nucleotide sequence ID" value="XM_019175438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF46"/>
    <dbReference type="GeneID" id="30192521"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN99464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="24265" checksum="B90F927CA82FFF54" modified="2017-01-18" version="1">MSQAIISPSVLASDLSNLTNECRRMMSNGCDWLHMDVMDGHFVPNITMGAPILEHVYKNVPDIFMDCHMMVSNPAQWVPEIAKAGGKLYTFHYEAEPTETEKVIDLIHEHKMLAGLAISPHTPSSAITDSLGSKADLLLVMTVRPGQGGQKFMPECLEKVTELRARFPGKNIQVDGGVGSGNACQCAKAGSNVLVAGTAVFGSKDPKQTISELRAAVDTAIAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF68</accession>
    <name>A0A1E3JF68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032600.1">
        <property type="nucleotide sequence ID" value="XM_019175497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF68"/>
    <dbReference type="GeneID" id="30192580"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="17507" checksum="2BFD711AE2852545" modified="2017-01-18" version="1">MAEQTEKAFQKQQLFQNAKSKGGKKIATKTKRWYKDVGLGFKTPSEAINGTYIDKKCPFTGEVSIRGRILNGIVHSTKMTNTIIIRREYLHFIPKYRRYEKRHKNLAAHCSPAFRVEVGDQVTVGQCRPLSKTVRFNVLRVSKNKAAKGFAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFA5</accession>
    <name>A0A1E3JFA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carnitine/acyl carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032604.1">
        <property type="nucleotide sequence ID" value="XM_019175501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFA5"/>
    <dbReference type="GeneID" id="30192584"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN99527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="333" mass="36008" checksum="4345A53A2C181840" modified="2017-01-18" version="1">MVNDQINNGNNNGKGKGSGETSPAVDFGAGVVAGVAGLVVGQPFDLVKSRFQSPSFSGQYTSTFGALSAILKEEKFRGLFKGVMSPMTDIFQINGVVFTSYSFFMKLQLPPGSQQDPSLGQIYLAGTGSGVVASLLTCPTELIKIRQQSAPPSLKLTTIGVLKSIVRQDGIRGIFRGLSATALRDTAYGPYFFTYEATLRLFRWMKRPPLPPAHHGPTHEGYTLIDEAEMELKSGLGWPELMAAGGVAGVLAWLVTFPVDVFKTRMQGFTWPNVLDPSQPRPSPPSFRHVARDALRKEGWRVMFAGLGPTLIRAVPTNMVIFLTFEGCVSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFB6</accession>
    <name>A0A1E3JFB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032601.1">
        <property type="nucleotide sequence ID" value="XM_019175498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFB6"/>
    <dbReference type="GeneID" id="30192581"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="36718" checksum="C21C3210AFE3C195" modified="2017-01-18" version="1">MPPRRPQTIETLLPPILDLLPDTYSAHQKALTTSARILHANPPQHAVAVEIFFAVGKELLKLGEGGSGTELGVKMVDTMSAAGVDVPDKTRANVTQLLALTPTTGPWRKKLVDAAIRWTQSTGECPTGDPNLHQYVGELYYREKQFVPAEQYLLASGKRDAAVTLANMMYEWCQKGALDPGPYALRGVLPPLLHSPPSILPAITFITTFLSLLSSPSSPFHPHIHPAIPSQTDASLPEIVVTASPSLTFAQLVVVTVQHAPKKGTSAIEARGTDGGVAREWRNLCMRYSKVSSVVAQREVQEALSQIAVEVFLVQPPRQAGNADLLQNLMGSLFGGGGGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIA1</accession>
    <name>A0A1E3JIA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032806.1">
        <property type="nucleotide sequence ID" value="XM_019175074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIA1"/>
    <dbReference type="GeneID" id="30192147"/>
    <dbReference type="OrthoDB" id="10403039at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130382" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44678" checksum="49C15228AE6043D2" modified="2017-01-18" version="1">MRFHLVLLASLSLSTSIIALAVNNAAPKDHLAARTALPKMNIATPAQYADNSTGTDGDGDGDDGTDTNLTPDDSMPEQEDDSDELEKRLWPSNPWWDWWKPNPTSSPTIPKPLTPQPEPTEDCEDTDGTDGGYDWVWLNERGEEVSRLFGSEREARWFDEQLERHLLADGAFENAHLIPRADELPAPTAHPSSQTSALFAHSSSPSSAPAPDHPTSSPASSPAPAPTHSSGITSYTHGSAPIQTNLPDAGNNKSSNPINIAVLVASILLIVFGTGLIGCILWALWKAHKRRQLFGSSSSSGGGGAGGGGLMRGGDEERVYQSGTPINKSRGDWEKGKFAGDESVDYSYAVNDLSYGGYGQLAVDSPTPVTGGKRGYDIQEAFERKRKSDELRYVLFLSLRLSLSWRREEADGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIS9</accession>
    <name>A0A1E3JIS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032950.1">
        <property type="nucleotide sequence ID" value="XM_019175218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIS9"/>
    <dbReference type="GeneID" id="30192298"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="521" mass="58363" checksum="D95E5C15C2F6083E" modified="2017-01-18" version="1">MLDLNRLVKDRRTAKITDKAIQECDLDWELPARPTHDNKKRGKQVGAEQKELRIASQTWARQEPAPREPITRLVWPKDADLNDERHPFQTGGPFPEDDAGEYYLDGEMRRNVLGGESASQRSTWTLGSIIGKHSNVDNILVFAEDKEDLDWAFEAGIMPPPHEVLTVICQPSFLDTTIIANGVESVTGSRKRNKKAVGGSMNMAFMWLTFVQDFLPNIPGAEGSSAFGKDLVTQFNMVFETTSFYKTINKTPLSEYLEDWDDFNYASESSFKATMKLYDLSRVKFKVIVSIPGVHHGASSERVGSGRLQRVLEEEGWMPREESRMTMAYKSSTLGKYRLAWLKNFYGKCAGLSKDDVPPDFHLRILYPTVKSIPDGHTNAELCCMCSCFGFNHVTRPLFRDVKPKRPNLINAKTISAVFEDITPVDVLPSGSSAPTRPPGSASGWMYVGTHSLYASAWGIYWQKAMGGGIKETRAKIFNFDMGIVFPLSSNPKVAAYQAQNVVPFQLPGGEYGEDDIPFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ62</accession>
    <name>A0A1E3JJ62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033035.1">
        <property type="nucleotide sequence ID" value="XM_019175302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ62"/>
    <dbReference type="GeneID" id="30192383"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="36748" checksum="4E19C0D1F6BA2D9F" modified="2017-01-18" version="1">MSLPKAILYSWPSSVWSTVPRLCLIEKGYAEDEYVVKYVNICTIPTLVVPTLETTGDDVDTRYRSLRDTVSICDFLDQARGANTSQTSSERPAPALAPATIEGTLHRDPQKSLSDLYLAKTLSDQVIELIHLPAVDPNFIAISAVNEAELKEKASDGPGKALSARKDALTKYLAEARQVVAGSTVAPKEGSTTFDQRIVQFLEEKLRTNEEVWKIYHGESASETLDLFYEVSQKAWKERLPEAFSQLENLIKGPYVLGDHLSLADLHAVSWMTRIVSIAGGLPDANGLDSIERKTGANLGEKTKKFWELWIERESFKQVLVPASSAFQEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJN1</accession>
    <name>A0A1E3JJN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit B 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033038.1">
        <property type="nucleotide sequence ID" value="XM_019175305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJN1"/>
    <dbReference type="GeneID" id="30192386"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="25354" checksum="BB9911F22DC5AA63" modified="2017-01-18" version="1">MLPAFRATALRTPAAFRPALAITRPLSNTAIALRPSTPTSSINTYSHAPSTTLPETTIAQQGSNQLSLETPRNGAEYVLSTLDKVVNWGRQGSMWPMTFGLACCAVEMMHMAAARYDQDRLGVVFRASPRQSDIMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPTAEALLYGMLQLMRKMRRNRQSVRWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKT3</accession>
    <name>A0A1E3JKT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032744.1">
        <property type="nucleotide sequence ID" value="XM_019175012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKT3"/>
    <dbReference type="GeneID" id="30192084"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="379"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="656" mass="72089" checksum="975266C7EB8E353B" modified="2017-01-18" version="1">MSRARLLRQLAPLAQHARVTIRPCSALPSRALTVPLSLGRFTKPYSTSPAQPTVEQQLQRLVSLLKEVSAVNSKAEKQRIISQYPDLREVLELIYEPNLRTHITSTQFHKLLSTPEPTPSPPPLDNLPSDIPTLFHLLSSRAVTGTAAKTLILSFLEAQGVRGKEELEDMFGRLLGRNLTGGFGARTLKEVQWPGEEGKKAEGGVKEEGGVKRKQGRPRKSPPPEPLVSEANSTTPKAKPSPKSSPATSYATPVLPNFGPLEKFEVALGKSIDPPFDALFSGRTGGGVWYASRKLDGVRVLTFLDFLVPPSADGEEGGGKPELIGTHFVSRSGRAFKSLSKLAGQLSTLAEYPKLGEILSYDTETIPLSPDSSSGTGIVKRLVLDGEVCVMRPKTPSELKISEAKDDGSPASGIWQANDPYVEDFPSTVSQVRKAATIQHLSYFLFDLLSWGEVHAKGALPGYGLSQTFSQRAQALQELTSWFDKELEGQGVGKEGRMVKELRQCKVEGLGDVEGMVERAAEEGWEGLILRKDALYKGKRSPDVRKFKKWQDAEYPVLSLTTSTMRLSINGTFAERQAMANVWIEHKGTKVAVGSGWTAEERVRYAERPEEIVGKEITVEFFEESERMGADGQKEGGKSLRFPRVKKVWEEGKRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL20</accession>
    <name>A0A1E3JL20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032814.1">
        <property type="nucleotide sequence ID" value="XM_019175082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL20"/>
    <dbReference type="GeneID" id="30192155"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027249" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="22"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="70337" checksum="4AEFE8B3228009D6" modified="2017-01-18" version="1">MLFRPAAALLAALPFLASTAAFYLPGTAPRDYQYGDNIDVFVNALTPMLNSKLRSLISHDYYDDRFHFCQPEGGPQKQPESLGSILFGDRILTSPYQINMLENSTCQKLCQSSVPKDDAKFINDRIKEDYGLNFLIDGLPSSEMKRDSKTGEIFLDAQGFNLGDDETDPTHPALNNHYDIYIQYHARDEHHFRVVGVLVYPRSVNSLVAGSSQPDCFNSAQYHLNEETGNEFFYTYSVSFLESDIPWGLRWDAYLHVFDPKIHWFSLVNSLIIAGFLVFMVGMILLRSISRDISRYNAVDLADDVQEDYGWKLVHGEVFRLPQRPMLLSVMVGNGSHLVMISIVTLVFALFGFLSPSNRGSLATVLLICWTFFGCVSGYTSARVFATIGGDEWKSNLALTTVLFPTVVFSLIGLFNLFLIFSGASGAVPFGTILAVLFLWFIISAPLTVAGYFLGMKHGAFTNPVRVASIPRQIPPKPWYLSTWPATILGGILPFGAAFVELYFVLSSLFGNRAYYAFGFLFLTFIVVALTTATVTVLFVYFLLCAEEYRWHWRSFMIGGGSAFWLFAYGVWYWASRLSLDSFTSVVLYFGYLFLFSLLDFLVGGAIGYVATYFALRRLYASIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM60</accession>
    <name>A0A1E3JM60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033192.1">
        <property type="nucleotide sequence ID" value="XM_019174813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM60"/>
    <dbReference type="GeneID" id="30191883"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="177"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="400" mass="45032" checksum="FBEAD78DD9354006" modified="2017-01-18" version="1">MVHSSPPFRAEHLGSLLRPATLLEARANQEAGKITAAELSQVEDEAVKATVDMQKELGFSPVTDGEYRRGVFWGSFFQELEGMTEVQNPPLDIFRTYVPDIAGFLEKGDRPGQSCLCTGKIKHTGKSTLIDEFSFTKSQVPAERAGDVKLTMISPVWYHLRYREGKAYPADVYANDEEYFADIAKAYRAELDILYEAGVRNVQIDDPNFAYFCSEKMIEGWNADKTNKRTLDELLDVYIKCYNDAIGQHKDKIHFGLHICRGNFRGSRHFSEGGYDLIATKLFKELDVSTYYLEYDTPRAGSFAPLAHLPADKNVILGVITSKFPELEDKEEMKNRVFEAADVMAKGVGQTREQALERVGVSPQCGFASHEEGNAIKWQDMKNKLQLVREVADSIWPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA8</accession>
    <name>A0A1E3JRA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-folding cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033451.1">
        <property type="nucleotide sequence ID" value="XM_019174399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA8"/>
    <dbReference type="GeneID" id="30191460"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="26495" checksum="D1087EF4311B8D8E" modified="2017-01-18" version="1">MTFISVFVTSPDTHSERKLDSDLTIQQLKDKLTPITGISPHYQILKIYRSAEQTSGAPLAVLDNDNRTLASYGLQEWNCIKANNTDPTYLPGEFTDDSNLDRFELTPEEYAARPDTVLAHIKANKLGRFADVPHNLTCPPPPPFSADQSIVPGARCEVSHGEDGLGKRGTVKFVGETEFGKGGVWVGVQLDEPFGKGDGEVEGKRYFTCPPKYALFVRPAKVTVGDFPEEDLFTDDDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRB4</accession>
    <name>A0A1E3JRB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033455.1">
        <property type="nucleotide sequence ID" value="XM_019174403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRB4"/>
    <dbReference type="GeneID" id="30191464"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="200" mass="22078" checksum="33F7497FAFC241B8" modified="2017-01-18" version="1">MTSQLSEAQALQKEIRGMELELARIKATYPPENRMTISRATDTLDAQTVELGQLMDDKEAVQVEADRTRGEVARIAKDVQRLGRDREREEAKAKEVREGREAGDTKVDDICRWLSSSMSFYRSLLGIRSVQAATDNELHLVYDVPNGPVTLALAFDPLIKRLSDATLIGSDLDVAEAVSVAIGNNDVPGLIADVLVRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRK6</accession>
    <name>A0A1E3JRK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033562.1">
        <property type="nucleotide sequence ID" value="XM_019174510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRK6"/>
    <dbReference type="GeneID" id="30191571"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15613" checksum="FE7142E85BE1808B" modified="2017-01-18" version="1">MARTKQTARKSTGGKAPRKQLATKAARKQTTAAAAGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSNAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRM0</accession>
    <name>A0A1E3JRM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033561.1">
        <property type="nucleotide sequence ID" value="XM_019174509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRM0"/>
    <dbReference type="GeneID" id="30191570"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO03510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="139" mass="14780" checksum="B0A61C6FF887EC73" modified="2017-01-18" version="1">MAPKSVASKAPASQASKAPAAASKAPAKAAKTSAAPKDGAKKRSKKRVESYASYIYKVLKQVHPDTGISNKAMNILNSFVSDIFERIATEASKLASYNHRSTISSREIQTSVRLILPGELSKHAISEGTKAVTKYSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRR6</accession>
    <name>A0A1E3JRR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033417.1">
        <property type="nucleotide sequence ID" value="XM_019174365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRR6"/>
    <dbReference type="GeneID" id="30191425"/>
    <dbReference type="OrthoDB" id="10285417at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38478" checksum="3309DEE2F9927487" modified="2017-01-18" version="1">MYIPKHIRMKKALKSTWPDYAVTGRKPELPLPAFPITSLLALKPVHTTILDALLFLSPRTYMLLSKEHYARTIPLSWRHVVLNMELIDAFAREESRERDNLQYTVSIRIAKVSQIAALESIPSHSSKRRIFERVRQVELTTTAFKALWDRGEQNQLDLGSIEECLGNDLEELLLWINRVPKKTFALPQKAFDQLLGTVPTVVTFVLAIPNSHAPSWPDMLERFPALLRHWYPSQRLRIVFKIPSQMVSLVRDELENAIITHIAFRARDKAEWSAGVSGCRVEYQLDGVDRLRAKMRAVFGMSDSASTGMIEDFVGEQCELVELAPHAFPFRRSGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRX0</accession>
    <name>A0A1E3JRX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033624.1">
        <property type="nucleotide sequence ID" value="XM_019174572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRX0"/>
    <dbReference type="GeneID" id="30191634"/>
    <dbReference type="OrthoDB" id="10314397at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="187" mass="20451" checksum="F6DE199DC4BB95EC" modified="2017-01-18" version="1">MTASVRSWATVSSSDDSSSDEDEQPPAFISVPNPTLDGSCFEPPPSNKPYKAHLAGGEDGWQNIATAADGLTSRYRCDDDATWNIEIPTEAGDKQQTLDLMVGRGHDGVTEAQWLELARSSVMKNETEKYPDLGDAVESAFPNAAEALRDEVVNKVTKELQTFRNLALAPHYDYFVDSTDSESSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD1</accession>
    <name>A0A1E3JWD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033823.1">
        <property type="nucleotide sequence ID" value="XM_019174016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD1"/>
    <dbReference type="GeneID" id="30191069"/>
    <dbReference type="OrthoDB" id="2570597at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="18165" checksum="DCFE91700EA3F427" modified="2017-01-18" version="1">MPPAITSSPIYNIQAINTLLASPVPQPVTSRIQLLSAKIHLLTNDPPSDPLSVLRTRRELGELYLKEKHDLKAAEIELSMVQRECKDIVKRIARERRLAQEGKTAIKSQDEVMRDEEMESSAVNLRVESMRLLVQVEEELGREGRAETWRKLIQDAGKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD2</accession>
    <name>A0A1E3JWD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033826.1">
        <property type="nucleotide sequence ID" value="XM_019174019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD2"/>
    <dbReference type="GeneID" id="30191072"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF265">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61965" checksum="6803F7F1CA2D0129" modified="2017-01-18" version="1">MPAKRPASSLSGPNKRPKPTTKRKQRTDKSVWNSKDDWDTLVAESSLSTSSVSLRKPRFRSFPSLTNISVDVIVRSFKAFYGDGQAGQDEAVADEWRKWWRTEWAEIPGHLKEMVRDGIYKRWGAILSLQLLRELFSIPPTLYLPGDLLPAIAQASRLKPLIPPTISSNLFMSLILINSLTSTDVGLAGLIHHLPSIEIVNLKGCALAGEKTVKTIVSRCPGVKRLNLKGTKVSEKDVAQLLATFGQQLEGFKVDNVIFNDIDHTFASQPYPSMTHLCLPGNMLNRPLSSARSNATRFTGMGYPNPRPTPQTTTISWPTLDTSFPSLTHLCLPGLLVPNGTEIGTAGLSLIKLALGPRGPPVPITSIEPIIKRHHNTLRSVHLGNVYPRGTKPGPDFDELAETIQSCDGLDTLRWQTDVHGTNDSLCDTSMSNYGHKLYWNLFETPLTVAQRVTLELPGQYKFPSAWSSGSTSQTFPSLLESLEIPSATLQDHESLAKLLCCYPKLRELDLSGTTIDDDDMKLILRHCPLISRIDLTSCRGVNVRHRRNIFKAFDEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWI1</accession>
    <name>A0A1E3JWI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033874.1">
        <property type="nucleotide sequence ID" value="XM_019174067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWI1"/>
    <dbReference type="GeneID" id="30191121"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="323" mass="36510" checksum="DCA2C91E7C361027" modified="2017-01-18" version="1">MRRIPSQIPSAVSRLLQGHVLQTPPTWYTPALSHPPPQLPPYQVKQRARPPLPSSSSHSTGQFYDTAPVPSGELERRDKLRGYKQRKSKPAKVFYEEDNVRRQFFKDFPYEALRPVSLVEGQEIDMREKINGLEWERLEQRGEYPSVEDCVEFVVNLKNTQGLPITEAYEQATEEFVQLRARHQLATVGAELEARHYGAQFKRDAFERHFDLEEKALDSLAPKSRSPATASLSARVKHRAQPRYQWTNSLSQEALPQDTFTGGEAYMARWRIPAPVQVEGVKKEGDLVSLLGGAGSEAKEGEQQAVQSDELDFLKAALNSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX47</accession>
    <name>A0A1E3JX47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034070.1">
        <property type="nucleotide sequence ID" value="XM_019174263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX47"/>
    <dbReference type="GeneID" id="30191321"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="53595" checksum="6A08C22DE0451BB8" modified="2017-01-18" version="1">MISRVPIRAVKYARPLSRRSPICLRFASSQNGSPSSKITTAPFRLSPGEALEKMHINALLASGKLASIPNIVYAFFLRFFGPSVTPIAREFGFGEKLELKDMKAALYPVWRVDGVAEGKVDIVHGEGQNQLKSPSPTLSMSVTEGYVPGNPFAPLSYLSFAVPPLYSDLPEYDPSKDHDQLKDYGLDIVPIPFTVSPLGLVNHIRRLIDKRTWDHWKIDEKKIEEKMLACYPIMFPIYIAEFEYDQGEDGKRRFNVFMDAHDESVKTCRVSWPPPPHLIEEGRFDRNYFVNPAPFMPVSTIGLYPLPPTPRSALIAAQRTRLPELYGNFMSPPPDLDDPSQIPPSPMYAAQQAASEGEGIDWEDERIMSWSGVGREENGDWIELYEKTQKGIETLETMRSFSSNNPHPEDLKGLVITSPLERRAGHSMIERKSLKDMEDQLERDVKRMKRELEESKPAWLRAWMQKQKGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX84</accession>
    <name>A0A1E3JX84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">L198_02124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034086.1">
        <property type="nucleotide sequence ID" value="XM_019174279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX84"/>
    <dbReference type="GeneID" id="30191337"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000013">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="42221" checksum="FAA7ADE4C86350E4" modified="2017-01-18" version="1">MTSTSAPSKKSLPDMMTSLKIVQSGQVEIVDQLLLPHSVEWLPVSTPEEAFDAIKTMRIRGAPAIASLAALTLRSYIASSSSPVSSSSSSSDTIAWVNKTIDYLQSSRPTAVNLGEAMDRIRAVLKDAEAKKLSAGEIVEQVKKVCGDVHDEDLERNMEMGRLGAEWLWKKRGAGKKGLKVITVCNTGSLATSGYGTAIGVITSLFQTDQLDTAYYAQTTPYHQGSRLTSLELTTLQIPACMVCDTMLGSLMQHEDIDGVIVGADRVVKNGDTANKIGTYQAAVLAQRHNVPFIVAAPVTTIDLSLQTGAEIHIEHRPAVEATQVRGLNTETGKLSVVRITPPGVGEGDKPWQRVYNPSFDVTPAELISAVVTEKGVAERKEGEKSIDVQSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JY20</accession>
    <name>A0A1E3JY20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033752.1">
        <property type="nucleotide sequence ID" value="XM_019173945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JY20"/>
    <dbReference type="GeneID" id="30190997"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="59999" checksum="18BCE39071D59DAC" modified="2017-01-18" version="1">MLDISITALEDPVAIVHIPIALTLADAYTSKIYWTLDAAERLSPEFFNITSNRIEASGSLLMAQEWAATADSEVLISPDWRVFEISSGDEDDVGNYDSPHLRHVSAPLARAGISILYQSSYFTDFLLVKESDFEKAAGIFSQEGWHVSPTAPSPRRPLPLPTPASSSFSSFSTSSSPSPTPSPQPEITVLPHPLACVGLSKTAEVRFAERLRKFLVWPERAVAVHSPVRDVSDDEDESEGEADELEDERRRLAPSRSARDLSPSQTHKRPFISYTRNEDGASLLTEIRILRAMFPAGEAGEEDHVQSGGELAWIDRDLGLDEAAADSGEEDDDWVEWEIQTPVDMQGAEVKELDGGVVEAFEKGHRKVLSLPCTPYEPLHVFHTHTHTQIDHKTQFIQTTQSIHSIDLASYSPGSISSNITATAIEPEVRVSFPTPSLLHAVELPIRWSGRKVKNEGKGKKRCLQMDLRSLSDAGHGDGEGIYHLDKSGLVTRFSSLLAGSSVKRPIRMLYSSTFHTANILVESRDVKRAKGLLERTRGSAEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYQ0</accession>
    <name>A0A1E3JYQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034124.1">
        <property type="nucleotide sequence ID" value="XM_019173419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYQ0"/>
    <dbReference type="GeneID" id="30190465"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="255" mass="28041" checksum="370D312EDB66DBF4" modified="2017-01-18" version="1">MTMKMYFHGTLGTDMLWFASWMPSSAGATVGVCIALFMLAIFERYLMAFRRACDVAWRKGQIGYARPTASGPLPTSTTATTTSTLSPSSLSQRHRSNPSIQKTTYNAVSAQDYPVNQDHQDPDADAEPVTPYTAGTQPSSGSSAPSYSLAQMQGTGRKAEKETVEKKEKREEGYAHLPKAVRRGLDPGREDRWSRPFRWGVDLPRGLLQALQTTIHYLLMLVVMTFNIWWCVAVIAGSGVGEMLFGRMGASHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ10</accession>
    <name>A0A1E3JZ10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034149.1">
        <property type="nucleotide sequence ID" value="XM_019173444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ10"/>
    <dbReference type="GeneID" id="30190491"/>
    <dbReference type="OrthoDB" id="2563869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="229" mass="25488" checksum="B1D8A29DE8B87387" modified="2017-01-18" version="1">MLLESLSTYPSLTPDTLHSFSPYPLSSREHLHKSLLHPSSASSSQAGPSTYRSSGISGIQLLPTNADPDEQAQDARQSAGMMRRRAEERVLMGRTPAGVMLGREDDEVTLEEEMMDQGQHDVTMFGHRFLLPYGRRQTQMEIDSAPSPSPSEADHERRQEDPSGILHHHHHPPDDDTENEDDEDVADLDGSVEDMDASQFDDEEDDDEGLEAEEAGVDLDDGMEDMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ25</accession>
    <name>A0A1E3JZ25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034228.1">
        <property type="nucleotide sequence ID" value="XM_019173523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ25"/>
    <dbReference type="GeneID" id="30190573"/>
    <dbReference type="OrthoDB" id="10603127at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="154" mass="14863" checksum="7DA66407C12C9719" modified="2017-01-18" version="1">MGILGGDDDETSSAAGASTGLTAASSSAADTKPASSSAAKEEESTTAKEATTTAAKAADAESSSSASPTTVANSGATSTGGVSDTVKSCLNQGLDSADCKSGTSANEGAIIGGAIGGALVIALIIYWLMKRKKKEGVKKGFWQGKAGMGGAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ41</accession>
    <name>A0A1E3JZ41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034125.1">
        <property type="nucleotide sequence ID" value="XM_019173420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ41"/>
    <dbReference type="GeneID" id="30190466"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="239" mass="25475" checksum="F27901DBB1B7B878" modified="2017-01-18" version="1">MSCCSDLPPVQAEYTPKGTYTTFSGLKTYVVGPGDAKAAVLYTYDIFGFSPQILQGADLIASQGYRVVMPDFLVGKYATPELFAPGAEAKKQEYISQFPAAIPTQSKPLADSIAALKAAGHSRVAILGACWGYKAAVMTEGLAGVDVFLAVHPTFPAPEDAEKINVPTLILSTSGEDKSVIDAIEKGVEAKNPGKNFFKRYADQQHGFAAARADLSGGDTLAAYVEAYQLIVKFLKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZK0</accession>
    <name>A0A1E3JZK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034380.1">
        <property type="nucleotide sequence ID" value="XM_019173675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZK0"/>
    <dbReference type="GeneID" id="30190725"/>
    <dbReference type="OrthoDB" id="10400835at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="407" mass="44881" checksum="F227B1898030E8BE" modified="2017-01-18" version="1">MYPNPERTHHLSSPFTPTPLTLPPNTPGYPFSSPGLLIWDLQEIAANNCAEAIKQFNNTHYKALLFGSGGRGWGKVGAGGGAGKTKEGSQEELLLLLSKHVNALGHSAARNGVGMSCVCWITELYAYIAEILCGSVNLYLAPGSPLPQFILVRLAELVHEGEAILNGLEEINFAALKPRGLNEDWKAVDLERKLVYLIRKLGSLAHHWGSAFEQSSQPPKEDDVLYAWEVEITGRWDSETDYAHTQQKDLIVQEEAEKKEREAKEAEEKREREAKEAENKREQEAKEAQDNKEREAQKAEKKKETEAAEAEERERAEEHEVVDAEEAERRRQASLKTQVRDEPVVAEGSGPGPAAPAQVTKPHVIAKPHDLPSSAAAGVRKQKSDASSQRKKSSKAKKDVGSACCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0Z3</accession>
    <name>A0A1E3K0Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034257.1">
        <property type="nucleotide sequence ID" value="XM_019173552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0Z3"/>
    <dbReference type="GeneID" id="30190602"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130691" evidence="3">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="38034" checksum="EE1D527DD655C37F" modified="2017-01-18" version="1">MKVLDILYSISLLSALSTLSFAAPLPESPTLADSTSISHLASNASPRALPDGVELVSLATLQTMERRMVFTGHAAGDGNGHVKREFHPVGRPDAADHVSSEGQIQHLAKRKKKTKTNFKTTTTIAAAAATEAASQGLKLAMVYESITSQKTSVGTITEKCLTPLNDPSQQFCQTLLDGQSLGGGDAGLTGSTGSSNSSSSSAVSSRSSSSVASSSSSAVASSSSSTTASVASSSAAVSSSSAVASADIASSTKAAAASISSSSSADTATASISSDSASVTESSTSSVDVTAASDGVSTSSVSSAALAAASGADQVTAIGAVSTTDVPGQNLQVLPIGLGIFGGLAAITLIVVGYVTWQRRRFKQQFRSRKLAEKAAPPGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1R8</accession>
    <name>A0A1E3K1R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034242.1">
        <property type="nucleotide sequence ID" value="XM_019173537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1R8"/>
    <dbReference type="GeneID" id="30190587"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="38002" checksum="0F9F0761760E07B2" modified="2017-01-18" version="1">MYYDLFSPFPIPAAQADQSATKKSKKAKGKAPAPTPSASPAPIKENLDCWEGLERQERDDVARRMAMIGHLGYSVTALTISIGEATNHVHPSPFQNKRPFPDLDPQSSNFSAPGSSNPGRTPLVQVARYHVRLDDGKAHCFTAANTQALRAYDILSVAPTTEKSFQLACTDLSNPGPNQISIITLPLHERPFTFRFNHKQMRQASRNGAVFELLYSAALFPPPSTPPDIARRYRQNFLSNAREVVRITGGKGIIFSSGPSSGNEASLRGCLDVVNLGTMIGMPANLAKEAVEKTPKMVLLRAQSRKTFKAIMTIPKYVPAPVEDTETESGKRPADVEGAGGESKKAKVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K270</accession>
    <name>A0A1E3K270_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034402.1">
        <property type="nucleotide sequence ID" value="XM_019173697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K270"/>
    <dbReference type="GeneID" id="30190747"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="743"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="941" mass="105310" checksum="D32356B51EE4F518" modified="2017-01-18" version="1">MEGAEVNHGNIFNIRSSPDGNRDREEYARQQRARIDQRHAATALNGKSSAKAVPTPSIFIPKKKPNALSSGSQGSSQGTSAAIAAKRRLDRDAVQDDSPRASSSALQTKSRTRAPPKDFAIELSDDSSPLNKPFATSASQRSKTTSSGLGNSEMQRRDREIERAEERKRRNAEIEREEKRTKDKMGEKEKNAPSNKKSAADDIYASIFATRDKLHAIEAGQPSLSSSNPTERQKAKSRTSPVAIPDKPKSKGKGKGREEYDCIDLISPAKTRHAKRPTAKQASSSEYDTVNEDDDNSDDELALGNTPPSHKHDIYRSSRAPPSSLPRPSSQRSHASTHSEQVLIPDSDEESSPGQSSGASRVRKRGSPERVAAPGYGDDDDDYYRDNSKKKKKKRMMDNGTGKLARQGVREEREKSLESVPSEPLSRATSKNPFAATSRTKSTALPPDKNAPKPKPKLKPPPPRQRQMFNQKTTGGKITIVSDDDASSEEELDEASKELLRKQMQIKAQQRANDRQLRAHDGAKKEEARKKEQQQKKAAGKAKKVVDENDKGHSFFKMLENMDVHDDLEEFDDDFLDGPSFNLDTTMEEDDDDDDWLVGNYTDAQRKWILRHVNTRNLCPYCDEPLPLNPTEHIENLKARLEKLSKPAPTTRNPNARDLHWQQAIEFCTLHRAEATIIPLGIQAGYPETIDFKNLDSRLEEGWVWAEIEKIVKDPSRSEMFLQVKREIESVGKMRWGGIMHQSRAERLLAVKPGYYGELGRVIMTDHFQKLQQWNYLSPCVPPARPGSDVTDDLILPISPLSAADFIANVLVPEASIFLIMDDNQCRSFDRDAYDDAARTREESAQYGNTKFREGDRQAKKLLEELRKGAPKKRERVKRLLGKKKVKPTNKEGDENKENRRPASSGAPAETGESSTKKASQQSSDMWEGEIDDATLLGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C3</accession>
    <name>A0A1E3K2C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034462.1">
        <property type="nucleotide sequence ID" value="XM_019173757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2C3"/>
    <dbReference type="GeneID" id="30190807"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="167" mass="19390" checksum="C42D00FF648D3AAE" modified="2017-01-18" version="1">MPHLASLPRHIQSRIAYHTVLDAPNAHPAALLPLLLACRTLNHNLTFAHNPQLYHELYLATFDSTAVTRRYQWMLTHIFTRGVKGYNLFSDPRPWAIDYRTRWELCGRWREVAKLGTIDIPGLCDYARFAEDLWDVFFLLSENGKLKPHSEQSLAADPSKTKRTWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3G1</accession>
    <name>A0A1E3K3G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035046.1">
        <property type="nucleotide sequence ID" value="XM_019173320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3G1"/>
    <dbReference type="GeneID" id="30190362"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000081">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="50889" checksum="3E1428184DC13E14" modified="2017-01-18" version="1">MLGAGLHGLKRALVIFPFAYTGIWLGYYAYTDTLRRHHIRDRNAKLAKTLSILPSSSTDKQLPGPDYTQPATEVEKEALKERYGSLKFAGRYWNPYVEWREQGAWEWAVWKGFISIVTLKLFYDGQVFLMIPGSMSDSSIEVYRPTDLYPIFLSSRQPPTSREPGSGGSDVAITDKFTSTWLGQSTTYVTMDNLAILTDPALQHRTIPSKFAPERLRPPPCSLDELKRVDLVLVSHNHYDHLDPLAIKELGDSCEWIVPIGVGPFLREHGATRVTELDWWQETQHTLSRPGQEPKSFTITAIPNMHWSARSPLDTNATLWSAFHVKSNTPSPETKPKSFIHLGDTGYSPTLYHAVGRVLGPIDHAAIPIGSYEPRWHMHLQHTDPEGAVRMALQMHVKKSVGVHWGTWLMSDEAYNKPPLDLEIARKKLNVEEEQFCVLPVGKTIVLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5G1</accession>
    <name>A0A1E3K5G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034959.1">
        <property type="nucleotide sequence ID" value="XM_019173233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5G1"/>
    <dbReference type="GeneID" id="30190274"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25233" checksum="0ADC49EC9F432328" modified="2017-01-18" version="1">MTSNNQDKVILITGTSQGIGEGIAKHYLKQGWTVIGVNRNPEKTPKLGGNIITVKADQSSLTDFHDVVKELRTKHNITQIDIVIANSGTGGPGALLKNASSTDLDYVYQVNTRGPLVLYQATRPLLKDNGTFVVISSLAGSLQRTFAWELIGFYGASKAAVNYLTRTIHYEEPALKAFTIDPGSVDTKSAREAWDAFGKPPVEASAVDDVIPGIVKVINDSTKEDTSGWMWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5W9</accession>
    <name>A0A1E3K5W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_00191</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035318.1">
        <property type="nucleotide sequence ID" value="XM_019172376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5W9"/>
    <dbReference type="GeneID" id="30189406"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="21" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODO08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="287" mass="32506" checksum="45413E795861CAF1" modified="2017-01-18" version="1">MFRPNSLLRATQGIPASSSATATAFRPLFAATRSFHATSSAQLATPVEAKPSKIKEFKIYRWNPDVPNEKPKLQSYKVDLSQCGPMMLDALIKIKNELDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPKDTKTESKIYPLPHMYVVKDLVPDLTHFYKQYKSIEPYLKNDNPPAQGEFLQTQEDRKKLDGMYECILCACCSTSCPSYWWNQDQYLGPAVLMQAYRWMADSRDAYGAERKEKMQNTMSLYRCHTIFNCSRTCPKGLNPAAAIAKMKLEMATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K634</accession>
    <name>A0A1E3K634_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035253.1">
        <property type="nucleotide sequence ID" value="XM_019172311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K634"/>
    <dbReference type="GeneID" id="30189339"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="985" mass="109785" checksum="DC93A61C4561D12C" modified="2017-01-18" version="1">MSASESNIPMREVSTATPPVTVPPASATEAVPISPQAPSAYPQPNFQSDSQPSSAPTAHPLLHEPSPGQPPKHNLHPPKLISTHLLAHPDHSASKAIRKVFPQPNPLMRLLRRFKVKHSVIDGLTEKEESRWEAQGHELRQRAGWKLEGEEGDGAVVSELFWKMYLSLLPTLERDPLSGLVPPDLLGSTTTMPLSIISLIPDIMQHYRDVIVRAEKEVFLATNYWQPSNSVNTITQALLDLSATIIKEKKPIITVKVMYDRGSWEQLWNAHAFVPPSGWTPLDLPAKDAIPGLNMEVINFHKVLLGTFHAKFLIVDRKVALINSNNIQDRPNLELMSHFEGPIVDAFYEIALHSWYNKLTPPLPCMGTPYAPPRDAEGNIQYLFQDHNPYFDDIEILKAARAARLLLRRQTKDNEDSRFAHHDTAGERLFAAVQKVVDQQRQRAAEWKPAEELEARAQTAMKELREFKDRWGLGMQGRMGSSSRVGSRGPSRRPSRERHRDEEKHRTLLAPSEGTSSPTITVELPPKSKTYPQPGDTLADDAWASRMIADGPQRRDTFDSEGISRHSLEHEHGEGRAKHHVAFAHEDGPMYGVRGLTESPNASTLNITEENAPGKAVANESGTIPGEDVTLQGRGRGRTLERTADQPTDAEILAAVSAGHGLKPAPTNSREETLPLSAQMPDEMAAGYETAKKSVALDIPEGKKSSTDETQPEGTGSKRMFQLSQRFNAGALSEAWATVEDSDDLDNYRPHVVHAPHEPFPIAMCCRKPHGFPGHHDIRNPQNAAWLAGFRYAKKKVFIQTPTLNARPIVRAVKQACRRGVDVYLLVDLGFNDKGESIPFQGGTNEEVVDRLFKKLKAEKKEQYLKVYWYTGKDQVRPLNAVVKQRNCHIKFAAFDDEVLIIGNGNQDSQSWFHSQEVNVMLDSRQIVAEMMDTLVSNQNTMKYGAVESDGVWRDEEGHTLEHYGATAKGQFRGLSGFIAFAKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K679</accession>
    <name>A0A1E3K679_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periodic tryptophan protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035543.1">
        <property type="nucleotide sequence ID" value="XM_019172601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K679"/>
    <dbReference type="GeneID" id="30189634"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001189">
        <property type="entry name" value="Periodic tryptophan protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="577" mass="62821" checksum="ECE5357C42A2A575" modified="2017-01-18" version="1">MSGTLISALTWVPRGRAAVKPKKYQLDDDEIERVGKLGGPGVLEKLKEEMAALEKAGAEGGDEEGDWEDEDAEEDDEDEKDSEEEEDEDEKMDEDGKPFDPSDMSAFKMDQYDEEVSGGVAMGAFANVKGLAYYQNNEEDPYITLKEDDDAIEEEELTVDPTDSMIITSRTTSDLSSLDFHVYSDAEENLYAHHDLMLPAFPLSVEWLDFAPGPQASEGAKPGNYVAVSSFDPSIEIWDADLVDGLYPSAILGPSPSLEKPEAKPAGTGKKKKKQMVQPTANDEHHVQPVLSLSWTPNHRNLLLSGSADGTVKLWDLTRESPMPAMRSWDKVHGGEKVQAVEWNRSTESGLDKVCLSAGYDRTVKVWDIRSVDEAIGVQVGSDVECIRWDPWEPFSFFVSLENGLVLCYDSRTLSSAKSSPLTTSSPKSSGFLTTAQPKYTLSAHDGPASALDVNPHIRGCILTGGMDKTVKIWNIQDAETEGIAGKKREISLATSRDLGLGKIFTAKWSPDAETPLALAAAGSKAQLQVWDAASNAGARKAFGDRLRRHGRELGEIKKGGGVVVVDGGEEDSDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T5</accession>
    <name>A0A1E3K6T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035763.1">
        <property type="nucleotide sequence ID" value="XM_019172821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T5"/>
    <dbReference type="GeneID" id="30189860"/>
    <dbReference type="OrthoDB" id="10306777at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="234" mass="26041" checksum="946221BE9B1E69DE" modified="2017-01-18" version="1">MQHTNPYNSHILPTFHTAKPDPTSPTSPNFPQYSPFAAPPEDAPPSFPSSTDNDQHPLRHRTLPGHQRHLSIEPVRKEEPGHSVYDQKEDIEDVVERVKAMDVGVCMAAVAMDAVAVVGFVLVWILVSQGKSSRTTRLCIALPYSLLSTCYILSRRKHNANDLSDLSRVMWHYGEDAVKGNAMKEGLGMLSWIILSGFWALWFAVGMGLVGWCWYGVDIYGDFLGAVCSKLPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7A5</accession>
    <name>A0A1E3K7A5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">L198_00147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035274.1">
        <property type="nucleotide sequence ID" value="XM_019172332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7A5"/>
    <dbReference type="GeneID" id="30189362"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="22531" checksum="93183AED8ABFE1C7" modified="2017-01-18" version="1">MSLDPNHLPSPAPTPSEALLLPGAPTPAPSAPPAAPDQEAIRTAVENQLLQLAQDLYEMEISAGYVRENREDAVPGYLENINKAFVNLSQLSSQMTDSVPHQIVEHVDRHKNPHTYTKQAITRATGENQYALGRVLGLESFRRQLHEAVSENFPEVPLPERRHQPIKPPQETNGGGEEGSESAQNVPNGGGAGETGAPDGPAAVNGQHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7T8</accession>
    <name>A0A1E3K7T8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035778.1">
        <property type="nucleotide sequence ID" value="XM_019172836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7T8"/>
    <dbReference type="GeneID" id="30189875"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="26073" checksum="B10842B607C101BD" modified="2017-01-18" version="1">MADTTEQVNPVEEHDPQFEPVVRLTEQVEAKTHEEDEESTFKMRAKLFRFHKDTTEWKERGTGDVRLLKHKTTNKVRLVMRRDKTLKVCANHIIGPEMKLSPNVGSDRSWVYNVAADYTEGEASAETLAIRFGNSENANLFKDAFEKAQTHNAEVSGTREDDDEEDDEEQAETKEETAETAAPSEPAAAEETKPAEEAAAPVATETKEAEAPAAEAKEEVAPAAEAAVAEEKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7W9</accession>
    <name>A0A1E3K7W9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035808.1">
        <property type="nucleotide sequence ID" value="XM_019172866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7W9"/>
    <dbReference type="GeneID" id="30189905"/>
    <dbReference type="OrthoDB" id="2573689at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="34781" checksum="BFC19E99B49DA5F3" modified="2017-01-18" version="1">MAQGIPQTSPSNIQKETPKQDQQTPVNNPKSTRTSPLGAVQLSTEDSGHGFPVHKIRVTSAGKGGNYAQFGLQWLLDVPDVPIVYHTLPPPPSASSSSKGPGSSSSKPTPKANNGLLPVTTTIPKLVTVVERVKREYIESILSGRGKKVDKKGKGKGKGKGGEEGEEKEKEVTGRGLWQYTETGNWTPEPVAGEGEDSDAALRRVLGGASRPKMKHHPYMSITLSTKPLPELEKIVPAQVVYAKSKKVRGKKKSKAKKQADEEMNVDETEEARVKKELGDGDDTEVDEPASQSQSTSKSKGREMKKRKSESEHGASKKKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9S2</accession>
    <name>A0A1E3H9S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08308</name>
        <name evidence="1" type="ORF">L198_08311</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000073">
        <property type="protein sequence ID" value="ODN73088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000072">
        <property type="protein sequence ID" value="ODN73093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027744.1">
        <property type="nucleotide sequence ID" value="XM_019180276.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027747.1">
        <property type="nucleotide sequence ID" value="XM_019180273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9S2"/>
    <dbReference type="GeneID" id="30197518"/>
    <dbReference type="GeneID" id="30197521"/>
    <dbReference type="OrthoDB" id="2577488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN73088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="283" mass="32453" checksum="E9CF92B873EA2C95" modified="2017-01-18" version="1">MSMQRPDAPLHRLPLPTELALKIFDIYTAITRPGTPEFLTLLTLSRYHYALNIRRLYRDAKVKEGMADTFLDMWMRWAFHAIQLLAAKRSMEHVVDEDEIVRNLLCPIKCTLTGFNINTLIFQNAICFAKISELLSIPGSSGWYLWELHPSLPHPVRLLHGAKTVVFEEQTLGGGEMRMVSYVLDGPRNGYTHYGAERLMFVMPSRPFHRISPLALNWLGVLGRRLPHVKHVTLEYRTAVVGERATLFKKRKHRLEQIDQVESKIKSWGKSSLQVTVVEPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBB8</accession>
    <name>A0A1E3HBB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_08281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027776.1">
        <property type="nucleotide sequence ID" value="XM_019180246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBB8"/>
    <dbReference type="GeneID" id="30197491"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN73630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="60376" checksum="B9E36A167F29C3F9" modified="2017-01-18" version="1">MQGNPPALHQWHLNGPGQTHNFRGPPLGIIQQRGTVSMPSSPLLGRYQASTDMGGIGWRAPQTAIQNEFSLPASASDTQSPHPLTNRNFPFQTQTPSAPAYEQQYMALNRSSPNHLASLQPSQTHPSLILGSDNGNSTYQPGSAFSMPSSNLSGIFPSNEQMENEGVDESGETGKKKRAQVRVACTHCQKACKKCSNTRPCERCVKYGLNDCVDSARKPRKTGIKRGPYKRRASKFVTNNQQTSNSYVPQHSYPPAHRHNQGDASATINGLANVTSPPWVLPQQQSIPAYPPGPRPTSFALTDALSAAITGPRWVNGQRVSPFGQQIPPMQVSADTEGRLPLAPGIANDPFSRAVSPIAPFSPSKLTRQRTADQIGRAEADRPDVSPVKSPSSSRVTSTRPSLSVVTSAHSRPPSAHSSHSPDPPETSSPYYVPAKIRKPSLWTLMSASSIPGSPVLVNPDTAHHPIVDHVPRTNIDKEVDSPTLFNQPMGMENLDLGSRGLDFETWIGLGSELKDGREMGDRGEAIPRRQSGQVTDGGDSARVMEGMGMAGFESLMGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD56</accession>
    <name>A0A1E3HD56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027807.1">
        <property type="nucleotide sequence ID" value="XM_019180206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD56"/>
    <dbReference type="GeneID" id="30197448"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="503" mass="56019" checksum="9217791677740950" modified="2017-01-18" version="1">MVVYLDDGDGVHSIRVLVRHPRIPATTPTFHQIASELGISPVHLSLRQRDKVDEVLARRVKMAKEMKEWKRADVMVGDTVRVVGALEEMRWKDGTVRQVLVSDNGGSIQVVPPEEQLHHAELVEQLHRELYNRPFAIPQITSARPIARGKIARSKTSLPSKRPNEEDEEGQHPASDITICTLSGSPTKSISQNLTPPRPRLRHPSKLPPSALTRPTFRRYLIHHLSSSIEDALSTIIREGGVERCRNALGRYFPAYLKYVKRRDGPGGGGGGSRAPLTAKQAIGPLTPLFEQDILSIPILHILARRIILQEALDAERERKGRIKSGLEKKDDRAIYEARRKLRKANEKVIARAKAGNPVEGEEQVQNATWLSEPQITTATTSLLTYTLRTAASSGELIPTRLSSLLTTSDSPYGYLSLPPQLLLPLLVPLIEKHSGWGLWGSRVGGGVTVQQLVRELQGWEEDGRWEKVSEGVVEGALEWGEEEEFVERQGGGWVLAQGYNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD68</accession>
    <name>A0A1E3HD68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_08239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027809.1">
        <property type="nucleotide sequence ID" value="XM_019180208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD68"/>
    <dbReference type="GeneID" id="30197450"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="38774" checksum="54CE88BE2CE8D5D1" modified="2017-01-18" version="1">MSFQGDVDVPDYANLRQHVHNPGWSDAQERIILEPYTYISTNPGKEIRSKLIAAFNLWLDVEPGDLEVITKVVRMLHNASLLMDDVEDSSELRRGLPVAHTIYGIPQTINTANYVYFQAFQHLLELGKDRLVGRGESGSGGRGRGGEKDLVEVVNEELLQLHRGQGMDLFWRDSLTCPTEKEYVDMVLGKAGGLLRLAVKLMMAKSDSKANYVPLVNLISIWFQIRDDYMNLSSTEYESNKGYCEDLTEGKFSFPIVHGIRADPSNRQILNVLQKKTTLPSLKHHVVTYLQHTTHSFTYTRSVLKSLEGQILEEIRELGGNGMLEGVVAALSLGEEVEEGGVEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH03</accession>
    <name>A0A1E3HH03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027889.1">
        <property type="nucleotide sequence ID" value="XM_019180120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH03"/>
    <dbReference type="GeneID" id="30197360"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="350"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125601" checksum="63745DA3349202ED" modified="2017-01-18" version="1">MSTHPNSNIKLFDDLDLSDLLNRVTLVGFDNTPKPPSDVDRFRFAPDAIAMGSLQGRLFTQVFGGGCAKGSDGRRNTSFIAFDFRREQLVFKVTTMLDSRSVPRVLHPIDAELSFNDIAQRGIHITKRAHPSAMGNPNLLEVTVTVGCRRPPRFCVPLDQSRRRATVMDFMISGAHEREAGSISTIPEGHCAYPTFCDTYRWIFRMDRQQYAKITACVQKIRALALDDPEMDLMSPSGENARWSVRILGDYEFQELYTPPDLSRLPFSTRTLLEGLIGYGVLRPVDTPNMIETLRKASPATPFQNRILEALFSQDRIRDVKALIPKLAAFLRRRPPSNQTHLVLIRTVLVTPMRVLVGPPQYESSNSVTRKYSDKLDGIIRVQFSDEDDRLYVYGSLKNADNENPAVGLMARVRRALQHGLNVGGETFYPVASSSSQQRDHSMWFINTRMIDGLSLRNWMGTVHETVVAKHAARMGLPFSTSRIVNMKINVGGQLADVKRNGRIFTDGVGLAGRNVLHESALALGEKKGIDSYPSVIQFRLGGAKGVLADWPKLVSKDDILLRPSNIKFTSDLADLNVIRVAKYQVAFLNRQFINIMCANGVPQELIISIFKDAVADINGFRDRVRDGKMTKADENLGRMCDNFPFMRLVRSGFNTNPLILDIAAILECKALQDLKWRARVKLPGGVFLIGIADETGTLREGEVFCQYQENDGTPPKIVTDEVLICRAPALHPGDVRRVSAVDAPELRHLKNVIVFSIQGERDLPEFLSAPSIDRLLIMFCRLGGGDLDGDDYTLIWDQRFVRSLSMYAPMEYEAPDPIREREVTQRHLNENFVQYILNDVLGQVDNCHLALSDRYTPFDGRCLELSEIHSLIFCSVDFAKTGQAATLHLHLRPDEWPDFMDKGGSVVSYTSHNILGKIFRLVQADPHFRPSDLERMSYPSDPRITRYPLNDGLLERLKVLKACYERDVQYDMRRYRVFEPEIPAGIAIRNKKRRRVRDENVNEPLREAFSFGVENVRDAAANILRDFTFEKTTLTPMQTIARHCYALTFEERFVRQWEQQHRQGHWGVEVLDDDDEEMLRPKPLMSFAFCFCQELIQIVSESDSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH73</accession>
    <name>A0A1E3HH73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadmium ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_08141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027922.1">
        <property type="nucleotide sequence ID" value="XM_019180112.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30197352"/>
    <dbReference type="OrthoDB" id="2563870at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001172">
        <property type="entry name" value="Cystic fibrosis transmembrane conductance regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="844"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="215"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="554"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="847"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1162"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN75684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1455" mass="161235" checksum="C8268C00CE3CA0CF" modified="2017-01-18" version="1">MIPFYKPVPAAPGVFQGQPLPEAKANIVSRILYHWATPVMRAGYSRPLEPDDLWSLTGDLECKNIADQLRANLLKRTPPSKRVSPSHPSPSSASYPRPRHQRTTSRNSHGRYSTSSSRAYFKQARESMFTIDGAEGYAVSHDSAHLLTMVDESEEDTRLLSKDKEESEGDIVKRYGKKKAKRIEDGELAVEDGKEYDMSLIKAMYATVWWAWWKAIIMKGCAAALQVTSPLLTKILIEQLTTAHQYYTGQSSDQPKSIGYGIGLSFALFAMVQAASLFSYQALQRGSVIGFMMRAALIDLISRKSMKLSSSAKVEMTSGKLTTMVSADASFLDFSAPMTLDLVVQPVQILVGLGLLIWTLGYSALVGLAVLALAGPLQAFMFTLMVRTRITQLTHVDARVRLLSETITSIRAVKLFAYVAYFSNKVTELRKKELIYLRKNGFNRASMNATMAVIPTLAAVLTFVTYGLTGHALTPSIIFSGLQYFNVLKTPIAFLPMCFTAVSDALVGIGRIGKLLRSEELPEGVNVRAESKWAVDVRGDYQFEKLLVEKKEEAGSQDEKKEEETPFMLKGVDMRIPRGALVCVVGRVGSGKSALLAGLINEMKQVQGHTIFGGSVSYVPQHPWIHSGTVRDNITFSSRPEEIDWARYNEVVDACALRSDIHAMANGDLTNVGEKGLLLSGGQRQRISLARAAYHPSSIILLDDPLSAVDAHVAHQILSDCIFSGPLAKRTRIMVTHQLDLLPKSDWIVVMENNGHGVGRVGQMGSWEGLKGRGMLGEMTKEMQAKREDFRTPTPSPSAARHPISPVKPSTNEKTDDTMEEDRQTGTIPWSVYTIYLRAMGTPLWGIVFGLFLILTQVASVGNSLLLGFWSSNSWGLSQGEYMAIYGALGIAIGLFTFGASYTMFLAGLRSSYTLFAKAWKHVMRAPMRWHDQTPSGRIINRLSKDIEMLDDRMAFAWETLLVNGLAAVGTFALILYVYPWLGLAFIPLIVFYYIAGGYYRQTSREVKRIDSNTRSHIYSSFGEQLEGSSVIRAFGKQNIFEKRMQSAINVQGAFPQFAYKSLLTTCRWLGVRLDFSSNLLILLIAIVGTVLRDTVDPSSFGVVFSYALAAAAMFSNLVSLYAQVELEMNNAERIIHYTSLPTEPLAISPLDSRDWPSRGAVDFHNLSLRYSPIGPWILKQLSFSVRAGEKVGVIGRTGAGKSSLVGALMRVVGKEGTEGKVKVDGLDIDDVGLDTLRNGVGLIPQEAFLFEGTVRENLDPLDQHNDSYLNSLLHLIHTDPIMPSTQSMKEKFRLDASVADGGSNFSGGEKQLLALIRALARGTKILLLDEATSSVDGETDALIQRIIQNHLKGVTLISIAHRLHTLAYYDRIMVLDQGRLVEYDSPLVLFDIRDSIFRQLCDRVNIRRQDLLRLRHDAVYAAQAARDHQSLYNDWTLAELWAQSGGFRMSQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJE4</accession>
    <name>A0A1E3HJE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027992.1">
        <property type="nucleotide sequence ID" value="XM_019180045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJE4"/>
    <dbReference type="GeneID" id="30197284"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101324" checksum="AB4BE33DEFCEDA46" modified="2017-01-18" version="1">MSFLRSVSLARKNQDSEASPIPQRAPSISGDSSPRAHNSSEASSIADDSSITPSKNNHGSKRKSMFGGKGRRRLSSLFSSSSTLSSYANDREGTSSPQPEPGPSNSITSSSLTFVRSNVTGSARSATAGAPAEGGIEFSQRGLSNLRIGTVTGEVTESPEASPTVELGSAIGARDAATKRTRRDSMWSQWELEGLGEDDSSSDEDDGFLTPSEGLSEVEEEDEDEVEPNALIQSAHLAAIAAATTIVLTASPSDFKVEPINVEKGALVTDTKNISGTGASTIHRSLPTMTETRVRRHVSHRPDAATVDQSAVLAKDIETCRGAIKLLLTSRMNEAEDFCQEKAGEGHHLYLQSTMGIIEALKGMMTFDSVNLHNSLDICKSTSITASTLRRANNNVMHRLGSLVTSGGGLARIKAMTPLERHAELVYAEQSLLKAMLAIVAGGDWIGLRREAMNVHAAHGIYRSLQQYLEDAEKHGYDDDIDMDFRSGVLLGTGTSSLMLSLLPGKVLKIAEVFGYAGDRTVALNTLMAVGGWTSGVAEPSLDETNEGLRRPICDMILLAYHLVILVLIPISGIDVPLARNVLAYNMKRYPDSVFFLYFQARLHTTQCQPAEANQSLQKALDLQLEYVQLQHMCLWDYACNHMMMGNFKGALDCFSILKDESNWSRAVYTYAAAACIVEMVEDGHKGASLEEADKLMRQISKLTKKIAGKSLRIEKFSSRKARKFESQGGRLFLPALELTYVFRSLCNTPRRSHLDVHIPRLNAMLGKLEVGEYEYGSKNGKEYWDDYVLGHFLRGMCHFIARWQPKDAIIPEKNVSPEDPSDEELDQAAEKDFKAVISHGPDVQLDHWVLFHCHYELGRLYAQRGNDELAKHQFEIVMSGKLPDHNPYMAKAAGKYSFEGALLLKTHAALSAVKEREKERSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJE7</accession>
    <name>A0A1E3HJE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027987.1">
        <property type="nucleotide sequence ID" value="XM_019180040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJE7"/>
    <dbReference type="GeneID" id="30197278"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="540"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="540"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="785" mass="85963" checksum="6ADEE04925CF9840" modified="2017-01-18" version="1">MPGVNQISTPSTLHSPTRSPRKSSHSRYYPTPLSMSPNANHNSLHYPPSFDPHHTSSRYPSNQGHAHSHSRSYSHSSSHSHRTAAPQGTYSVYSPYRPGEYGRSERGVMMGDRTGTGTGVERKLFVEGDEVQEEEGGWRGHRASSPLAPAFEPKMVLRNGASIDLISWLRTNFIHSAPPHNAITPPMPLNGIRHLLLERFPRAPEVSEIHKAVLAAFPHSQWDYAENNSEPPSMRGLKWAGRDVEEDYELEEGYEARYREGANGAVNGAARQSQPRGRISNGNGTKQSRSPTQSTLVSPISSSKRPLPDTPARSVLEEFAEIATLTGKTPGSRTKSLPGETLAASPDSADLAVEDGLLLKGKKRVATDSPERSGGHQRRASSSDKLHGLLAAAEAVEGSPLTTILPPNATASANAHKRRRTIGGSPPAREMMAFPRRALSARGTMSPPPVNGMGHGQRGSGSGNGLGQVEENVDYVVPLNDTAFAAPASASSSSSALPGPLTATANGKPTSSSAAATPSRTSRKLNELPTDGDRPGFDCKPPYPYHEMIRHAIEQAPDRRLQLNQIYASIAERFPFFKTLDEKKTAGWQNSIRHNLSLKKMFVRVNKIDGIPDDTAGKGGWWTVIPGVPDEGRPGRKAKARKAKELAARQLLIDQQAAEEAKGLDEARARDRGGEHDGPEPSPAELARMDRERMMDMERQREREREHELRQREKREREAREAMAWVEQQDRAEMAERERRRKEGKENEPLLAGAGGRVLMGEAPREYVAGDKRPEGWMGGMNGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HKU1</accession>
    <name>A0A1E3HKU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027947.1">
        <property type="nucleotide sequence ID" value="XM_019180093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HKU1"/>
    <dbReference type="GeneID" id="30197333"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000033">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="638" mass="70807" checksum="A3EC1BACCFAAB4C4" modified="2017-01-18" version="1">MPKLPPSSGGTLPTDDYELQPASNVDDPLLPSYERRTFPSPHQQLQLQKQSLRARSVFRCLCISLAILLPSLAFVTCYFGQTTLDRVRTWESLPKEVQEWLDGVAPLKSVADHSNFPTKAALIATAPVFPTHTDVHPLLRPTENVSKGFSVIQHWGNLSPYYSVDSHGLPDSNSLIPETCELKSLHWLQRHGARYPTSNPYGPAALASRLKTATDWTAKGDLAFLNNWSYKLGAEILTPFGRSQLFNLGVAARVKYGFLLDKFNGRLPVFRTESQDRMLRSAQNFATGFFGYPSEEQYNLEVTIESPGFNNTLAPYSTCRPNYDFVKKLAEWDAVSLPETRDRLQENMEGLALTLTDVNEMMEMCAYETVALGQSAFCNLFTQQEWKNFQYRNDLFWWYGSSFGYKPARAMAVGWVQELVSRLTKSELTEFNSTTNSSLHDDVHFPLDDPLFVDFTHDTQFALLLPMMNLTTFAESGNLPTDRIPKHRSFVSSKIMPFATNLQIQVLSCSSSSSSSSSSSSSSSTSSSSSSKNIRIILNDAPVPLTGVSGCPQDDDGLCPLDTFVAAMKTLIGEVDFATDCAYKGGSKEELEKEFREGELVVEEGEKTKGGKSGDGKKVEDGEEDGDDSDSDSDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRS4</accession>
    <name>A0A1E3HRS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028106.1">
        <property type="nucleotide sequence ID" value="XM_019179930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRS4"/>
    <dbReference type="GeneID" id="30197168"/>
    <dbReference type="OrthoDB" id="10369775at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="30014" checksum="B160D5387830977B" modified="2017-01-18" version="1">MKIDDKDHKNNDEEGGDTYSDDYEDFYSSSAQLLVETLNQEIRSLPAYTETNSAASQAQAPSSLTFLRVKVVGKWSTSTGADGRRPGTLHPAHRHTVAEALSEMTEDINSAIASQFPKSTPEQTAILAQRTLSRMVEMIGFDGDVHVTATPGGTQENSRLTTMERDDVARLAGQRTLGVSKRMDSKSYNSPSSSSILSLTNKNQNQPTMSSNARDQESTYSQMPTNASIRQEIIDEDPSLYTAEEADAVRSAFGGNGSEEQVATQSDEAEASSDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV77</accession>
    <name>A0A1E3HV77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028170.1">
        <property type="nucleotide sequence ID" value="XM_019179866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV77"/>
    <dbReference type="GeneID" id="30197096"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="73" mass="7567" checksum="D6BAAF0E72D02CBC" modified="2017-01-18" version="1">MTGLGFGRGYAAQGGDIGSFVTNALGVYHEECKLIHLNFRLLLGKPTGSTPSPSSTQQSQPPDPLLPHNAGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVJ6</accession>
    <name>A0A1E3HVJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028180.1">
        <property type="nucleotide sequence ID" value="XM_019179813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVJ6"/>
    <dbReference type="GeneID" id="30197042"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="819"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1277" mass="135319" checksum="6369663B15BA0FB5" modified="2017-01-18" version="1">MSHPPSRNSSVPRLRAPSTLRSPPSPRYSTAPSISLVFAHGSSDTPRPAPSNNPARSGSASEEALSRQLDGASGGRHMGLRSRRSSTATTATTATMGGTNGGERQESGSVLSEEPEDIGDTVSSPLAGPSSLPMGSEGSKRQADGEAGSEMAGGGRESIKRKLNGKASSAWLKWSSATSKLPPNVLPGGSAKGKERAVDEEDKGNPDQIASESPPIDAPVTSDTESPMHTLPPTDPPPKTEPLAVPKPADLKRTPSTRSSSPLKDATQEQRDEIMRTRKPSGMGKGDRGGWWRSLSRGTKGLGVEKEKDGKAGSGPGEESGKVVKPEEAQQSSPKTNVPAPPTEDDPTPIPTSEPSSLPPSKSEPEPAPKPPAPEPAAPEPLPSASPSTTQTSPPPTLEPEFKPTNNAPSLSSARGWKDYLSWSKANSPGGSVSESGEGSAPSDGVGLEPPSDERPSDPDSTPKAAQPPSTWSSYFYALVAEQKAKASAPEAARPVEPTAVDEEQMPIPALPTDVRKPPPAPEPFATPFATPSSHTEPASPSSSPLRPPNPANGNVSSSRRSSAAGWLNYLAFRASQKKVDAGAGSGSVDTGTEESSVMDFSNDPHFPADPPVSGINPNQLAPPSGKETSRGREGGRERERERGGGAVSVTPKASQNLEVARKRLSSASSVSNGTTGSVSTSPNPKSSQASPNKMTKNGSALPHPLPPSVQPNLVIPTFATTFDRPPRSFLPLPPTSPPSSPTAKQEQRGLAATTTGYAWKALGAVGSYMYGEAPPKTTSESLKEDEGETRGRGEGRKVGGDLPRRVGLGVGGPDDGWKNVRRVVVIGVHGWFPAKMLNSVIGEPTGTSVKFANMMGQAVKQFFDEKGVDDLRLTLMPLEGEGTIDSRVDKLYKAYLSNPAWINDLRRADAIFFAAHSQGCIVTTHLISRMIAQGHIRTSHNAEAVSRCEWAFGPIGVVPPSSPHRRHSSEQHSSSIPGAEGGKQKVAMLSMCGVHLGPLYSISTSSVIQPYLQWFENAAARELFEFQDTTSPVSLAYQRALAMVLENEVRVVLLASLNDQVVPIYGASFSCATHPLLLRALYVDGASYTQSDFMTNLLCFAFMLRNAGIDDERLVEHLSEATAGGLTGLGHSTPYEELSSFSLAVNYLFYATPARKPLPPLQIEPFNARDARNDFELPWIMRALVDAPEVKDLFPGELKDLKEGIVHWKPVTRTLKDIKRRLEPMAGRQSRLRPLPNSPSSASLVSQGAADHHTGTSPVNSKNLTAGKKTHQRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HWV2</accession>
    <name>A0A1E3HWV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028146.1">
        <property type="nucleotide sequence ID" value="XM_019179842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HWV2"/>
    <dbReference type="GeneID" id="30197072"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="469" mass="53111" checksum="729AD73ED88AD75F" modified="2017-01-18" version="1">MRVTLPNPLGEPVTLDSDRIPRPAAILPTAVTRLARRSQLKLLLLLFGFAVLITWHPSPPFPPSYDDEWNWEKRVAKEQGQPARMIQFDIPKGTGTLVILIRFRLQHHLAVLGNRSLSYEPYVEDTTILPFNPTNWPWRSAKIPLSAFISTVVSGFETLYDSPRAVPSWYYRAHCPSHKQVVYTIQSPSNPDGKIDLESNGQDRIHQLQVLLGGSDDPCIRIQGEPFDNNFFNSHAPLDLYESFIKSPAMEHFSFSPRVLSILNDRLQILSPTTPLYDLEAAAEGKGKSAISTPIWKHVLAMHIRRGEDWERVCEEKGETSANMVSFNKLPLLPGNENVPPSTDMVEATRMGLYRAKCLPETLDIIGRARRMRKNHPLLKSVYILTDTDDAAWVGEMKKWLESEGWDHVWIGKDDVWGGWEEKEVGVAVDMEIARRAGVFVGNGFSMTSSNIVLLRARDGLHPDLTQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I146</accession>
    <name>A0A1E3I146_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028274.1">
        <property type="nucleotide sequence ID" value="XM_019179727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I146"/>
    <dbReference type="GeneID" id="30196950"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN82319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="438" mass="48274" checksum="9E70F35D461C3F04" modified="2017-01-18" version="1">MGQSPSSGAGGNKKPGPNDKKDKPKWEPPVPTRIGKKKKRGPDASSRLPAVYPTTRCRLKLLKMERIQDYLLMEEEFVSNQAAQSGEDKTAADRTRVDELRGSPMGVGTLEEIIDDDHAIVSSGGGSEYYVNIMSFVDKDLLEPGCSVLLHHKNHAVVGVLADDTDPMVSVMKLDKAPTESYADIGGLESQIQEIKESVELPLTHPELYEEMGIRPPKGVILYGVPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAVGTKRYDSTSSGEREIQRTMLELLNQLDGFDTRGDVKVIMATNKIESLDPALIRPGRIDRKIEFPLPDTKTKRHIFKLHTSRMSLAEDVDIEELVMTKDELSGADIKAVCTEAGLLALRERRMRVTKADFTAAKEKVLYGKDENTPAGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5Y6</accession>
    <name>A0A1E3I5Y6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028357.1">
        <property type="nucleotide sequence ID" value="XM_019179669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5Y6"/>
    <dbReference type="GeneID" id="30196892"/>
    <dbReference type="OrthoDB" id="10323955at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="43292" checksum="2A9DBF442B8A0505" modified="2017-01-18" version="1">MPLQNSPIPLRPNQRIHTTAPTLRRGKTLSDKLIEARDDNTLSHEREMRKKKSFGREVGIGVAFFHEDTVESIERFITPFKPKDDDEDDIADAATNEKNARNGANSKITPPAPEPTVTDDVPAPAASDQHAPTPFPTIPSLILPPKPSRTLPAGEERAKIGHRKKLSREIEEAREEDRLREEELFKEKMEALTTVDHDSVKSSDEVNDPFSTTASRGSVTPSSALSEAATIHIDNENSESVYTPPESAFKDRDETMAQMRKEMAAIREAKKLKLQGFPLDDDISFTPKQTVEARIMHDTNHAPGRNIFDPTNPIPPKPLPIDTPIEANDPAFTGQSTDKWSYLPDTAKVLASKILGVSGLGSFWGEKMVEDGGAIVVDERDGKPPADKTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAL4</accession>
    <name>A0A1E3IAL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028544.1">
        <property type="nucleotide sequence ID" value="XM_019179506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAL4"/>
    <dbReference type="GeneID" id="30196723"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="55"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN85683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="449" mass="48265" checksum="E09E6E875D60D4F0" modified="2017-01-18" version="1">MPTTIVAPLAILPGSHAPQPATIVYDNGVITSIRPGLLAKDAVEGDLIEVAEGKVLLPGLLDAHVHLNQPGRTAWEGFQTGTLAALAGGVTTLIDMPLNSIPPTCTVEGLYAKRAEAKRVGIKTDVGFWGGIIPGNAGELKPLLKEGVKGFKCFLIESGVDEFPCVDEQDLIKACDALEGTNALVMFHAEMDSHPHSSSPPDPTHYSTFLASRPPTWEIDALSLILRLAKKYSGLRFHIVHLSAAGAVPLIKKARKEGLSNLTVETCFHYICLSGEDIPDNATQYKCCPPIRDEANRKLIVEALLDGTITYLVSDHSPCVPELKKGDFMSAWGGVSGLGFGLSLTWTLLGGKGGRVELGQIVEWMGSTQALQVMLKGKKGELMVGADADFVVFDPDAEWEVTLDTLRFKNKVSPYLGKTLKGLVEKTYLGGKLAWDRGKEVNDVVGKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAM3</accession>
    <name>A0A1E3IAM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028515.1">
        <property type="nucleotide sequence ID" value="XM_019179477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAM3"/>
    <dbReference type="GeneID" id="30196694"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN85654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="80474" checksum="380B908934B6F932" modified="2017-01-18" version="1">MVYTTACESCRKVRMKCIRPSRGMDQSETCERCEQNHAECITIKRRVGRQPGVKNRKRKGEVLSEHHQSKYQIVHQEHTIPRDVIDHLPNPLHVLASEAVRRQSSPETSDDQISHASTSTRTSKTIVDQYSEWADKLHPNAGAGREAIMIHLDKLLSMGPRPHAVDAEEPSVFVGRTDMARPDASPENDVISLRIISLADAQHLFDKFMTLIINGSKYFDPRIHTLSYVRSRSSFLLAVILAIASTYKPLCPSSILHSHLMSHALKLETTVRNNHLKSIEIIQALLLLASWTEVPCTLSRDKTWMFVSHAIALAVELRLDSPLPHCVQTDPMFDKNNQDLLVRNAHRVCLLMFIHDRNMAMVAGRHPIIRDTSLVSTESLSKWGKHALAHKFDAPICASVSLRKLVTVAHVKLTTHNFADFAAGKEFIDRGMADWRKRWAVESTSTHEYDIIARFSAFVLALALVKKRQATGHIESEARKVCEALAFDVCCGAINHYKTWQGLPNSATFDTSMVAFCAIYTLQSIHLTASPFLSDWSLLRLATLQELLSCLETQADERHGVDTEGSLSVVEQVARGIRNLLGKKQIWRGGSRGSFRESEDGEYYGLSQAHNLQPDPYATSNNHTHNQSTNAPSWPTNSTMDDLTHFLYAATDGSLPFMADWDFEGLLPSYGSNTANASHSGGAGRDMSTFGVETSFTGSDPGSVAEMSQGVNMQNMFNMGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB64</accession>
    <name>A0A1E3IB64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028574.1">
        <property type="nucleotide sequence ID" value="XM_019179433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB64"/>
    <dbReference type="GeneID" id="30196644"/>
    <dbReference type="OrthoDB" id="2577619at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="192" mass="21499" checksum="ABCD9BA9BF35CFB2" modified="2017-01-18" version="1">MTKATDNTESTVSKDSQSTVFPPDSRISGVSSNGAKHMCYCAMHLQPGESDQPSWTGGKPMINNKRHSGRIHFSDRESTIFEFPCLSTAIILSFRDDDPAEDEMLVGNVTKSKLDEMGLWPTYRDGFKTVTGVECGLLIHGEFENMFEGDPIMEIDHSVLTDRPTFDDAYDDFFSSNTVKTELRDEYMSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICG4</accession>
    <name>A0A1E3ICG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028462.1">
        <property type="nucleotide sequence ID" value="XM_019179516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICG4"/>
    <dbReference type="GeneID" id="30196733"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="323" mass="35474" checksum="CBCD75473DAF92EE" modified="2017-01-18" version="1">MPPRRTRKAAAAEAAPKSPSPEPEAVEEPPAKRAKKMTTVTVAEEAGEEAHVETEGVQDNSPDTMPVEDEAKDTPKAGDEEETEEWDPSEERLPGETGKKGKGEEKAQDEPSAGEDQAEGGDTKGWQAVWAPEQNAYYFWNSNSGEVTWTNPLAPPPLPQDASQPPLPNEPPPLPAGPAPTESAPVSAAPDVDPHNQFGQLPEIDPALALLLPPSQRGNSGAPGGADAHLVQQATFNARTGRFTPLDYQYTVGHLDEYNRAKRMNSHYFDVEAWERQKAEESERKAREEANGGRKTTTTRKDMDRYRKKAAEKKQRNQAWLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID44</accession>
    <name>A0A1E3ID44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028522.1">
        <property type="nucleotide sequence ID" value="XM_019179484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID44"/>
    <dbReference type="GeneID" id="30196701"/>
    <dbReference type="OrthoDB" id="2138242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="539" mass="58544" checksum="C9E56BE6D5168559" modified="2017-01-18" version="1">MQISPILAPTSLHANYITPPPTVPSSRRVSFGASRPTIINDTTPRSRRRTSSPDRNAEEEDGQGGKRRKLTRPKPSPLRVQPPDSHSPSKDSGPSTGGSSVSVGRRVASGGLQQQQQGLPKPIGFAAAREARREEGYDVYGMVPSPVVMGFDFKLVEGEQLKTVRESLSIKEQQQALIAARRREAEAAANSNPSTPRDPSMVPAQPQKTGPDPAMTLAVPTSGSVGKRREKVKDKVDKMTIMTGIAGKDAVPGSRSAPLNQNLAIQQSVPRDIPSGSQTALPPNSLPPNSLPPNSLPPNSLPSFSSSFQHFSTDPRTAPISHARGNGMQDRGEGAEFARQQGYYWRLDGGRGPGHANGANGLGSRPPVMPDEGRRNFTVPSIALPRLEGHMSPVKSRNTSGAPHSVSISRNHSHQSISHSQSTSPRSQPPPPAAPIPSREAFLNPFATLYDSLSQTTHLQSTLTALLHSSENLTAQQARQMEEFKSTMSMAKGLLGSLQSSADSLREMVRYEVERRGREDRREMEEMKERLRRLEEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFD2</accession>
    <name>A0A1E3IFD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongin-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028909.1">
        <property type="nucleotide sequence ID" value="XM_019179151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFD2"/>
    <dbReference type="GeneID" id="30196348"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="471" mass="51794" checksum="DFEA572016CC93CE" modified="2017-01-18" version="1">MAANHLEYEEGDEDLFGDTDLLGFSSVNPSAPINLAPPAVAGPSSNPLSPNRPVRQQEKPREHLYPHIVSGARSTRTNEDERLAELRDRKRAGREQAPRKGVKSLRLISMNVIQQNSSGIWDIGDMEYSVLRPFLDEVGAEQLAEIERNSPHIKKDTDWLWEVLLLQDYRLFHERCRINREGEVRTSGWRKMYKRAKEDALERQSQAADRVAARYKQLEQEKKSKSIVVLDKVMPGKKPTRSRGRGGSSVGSTSSRPSAAATSIAKARAEAQRARIALTHASGRYVPPTQTLTQAQRVSQSQLFKNPYMSGRPTPSGSERQAQPATVRIPAPRRVAKSAAVASRPRDVIASPPSSPIPGSFPSSQYPQVRASLPSHLSSQPSPASPQSSERFRIDSKTLGTKKTFKEIKKPEVRSFEPPVLEKEKPKQKTDFFGGAASSADGGGIFRVKKRKPGVVGGASGPPAKRPAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL6</accession>
    <name>A0A1E3IFL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028724.1">
        <property type="nucleotide sequence ID" value="XM_019179243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL6"/>
    <dbReference type="GeneID" id="30196446"/>
    <dbReference type="OrthoDB" id="10525646at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="226" mass="24279" checksum="50F0039113BC64AE" modified="2017-01-18" version="1">MGPFEAPRRSSNLPDIIPSRYSATPQTPHLIPQMSCRTYSSLTLCIAHILSSNQLEKCPTQVKIFTLTGAGGHVVLLPAIHIHSPKLEVVQGAEVEGEDEVAAEEAPGVGIWNPRVRVAKAVGPETRKLVRIVSDDMSEPLTTSVPLNNSERPASAPVPSGSNATLRATLTDLVIGFLPLHRLFAVDKPPPRSPLPYIIPDTMAGYGVAVKAVYEDIVCQRTATHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJV4</accession>
    <name>A0A1E3IJV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029356.1">
        <property type="nucleotide sequence ID" value="XM_019178655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJV4"/>
    <dbReference type="GeneID" id="30195812"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="334" mass="37207" checksum="91817A68F419F6A3" modified="2017-01-18" version="1">MPPRKSKARDVKSTAPSPSLSVAATATRGSSRSSKSKSSDVGQSTDVETVTEQEQEESVEVEASTDAGVEESVEGEESAAPEDEGEAEKTGKVSMAERMAKMKELRMKMSQTSQENRRDLVADHQKNKTTAKDLARLEKQRKLAQTLRLKADAEEAGEDVERKKNWEYSIEDDERWAKKEAEKEAKQDQHFHNAEDDAWKRYERNIRGTKADLMAYERQKEAALGLAPGTLVPVAGGSSSAAGSSSALTKSEDLYRGADTLAYGDNKPSEEAVDRVMAKINKDVGKKKRGKKDEEDSEVDYINDRNRVFNKKISRYFDKYTKDIRANLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM58</accession>
    <name>A0A1E3IM58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06374</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029593.1">
        <property type="nucleotide sequence ID" value="XM_019178437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM58"/>
    <dbReference type="GeneID" id="30195586"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="39652" checksum="4BB6FB207784BA48" modified="2017-01-18" version="1">MADKTFKIAVLPGDGIGPEVVAEAVRVLETITANSDLKIELKNYDFGGAGIDAQGVPLPDDTLAACKEADAVLMGSVGGPKWGVGPVRPEQGILKLRKELGLYANIRPANFASENLLKRSPLKEETAKGTDIIVIRELIGGIYFGERQETNKEGVAWDQCIYSKSEIERITRVAAQVALAAEPPLPITSVDKANVLATSRLWRKTVTELMAKEYPQLKLEHQLVDSAAMIMIANPRKLNGVLLTENMFGDILSDESSVIPGSLGLLPSASLASAPDPKSTTMGLYEPIHGSAPDIAGQGIANPIGTILSAAMLLRYSLGRGKEAALIEQAVQKVLDSRESGGFDIQTKDLGGETKTSEVGDKVVEVLKGLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA1</accession>
    <name>A0A1E3IMA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029642.1">
        <property type="nucleotide sequence ID" value="XM_019178486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA1"/>
    <dbReference type="GeneID" id="30195639"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="168" mass="18733" checksum="F434652303C66A66" modified="2017-01-18" version="1">MPATNGLGTVRSLKFPPACRYAADTLDFAAPSLTPDEYETVKQHGDWTGFMQSHELKPWDHDDIDEAHEIVKDDDDQDPVYEVRYDDGEEAEVGTFGQDYAEGDGGDDGYVPGDSGDFVDGEDHDDYHDGGVVDDYPEDYDQGYDYGDDDGGDSFDQDYDEDYDSGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INF1</accession>
    <name>A0A1E3INF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029506.1">
        <property type="nucleotide sequence ID" value="XM_019178599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INF1"/>
    <dbReference type="GeneID" id="30195756"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53517" checksum="01F623014F1CF6B7" modified="2017-01-18" version="1">MTAVDDILLTALKEHEHRESDAHITIQEHIHRIKTQLGDASAISPYSKSSAPLSVVSFKCLLQDTGYPMEVYLPGDMEMSSDVDWSKLKERWVGWGVEVPGEQQWTKPQADITAGLQGISIGSQDLPASVHAKTPLPQQQGGSYLGALLKVYDDIAYKPASVHEFIGLLSTSPIPSNEPEDADIVPTIHVLSKRDLAPETTDVDPSDDQVREELVDYLSTAFNPPDRVAAEFLLLLLISSPTARPMSLPVLGTLAVNFRHSGESFTSAFNSVVSSVVPHYVPLPLTLSLLHSHPFQPAMTDANGLNAGLLQLADGTVLAVEEDAMGNGGQLNEKALKNLKALVDCVEEQKVNYEYPYMDGLKMDCSVKVAVLSQGKSLIPVDVDIPICADGSPSTRPPSLDAFRSYLARYSSPAHSARLVIPDESSTIIQDHFVQERKVNRKEAEEVLKRRMKIARIVALSYPKAALDGQVWDKTVKLDEQVAKRHTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP20</accession>
    <name>A0A1E3IP20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029585.1">
        <property type="nucleotide sequence ID" value="XM_019178429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP20"/>
    <dbReference type="GeneID" id="30195578"/>
    <dbReference type="OrthoDB" id="3353673at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46474" checksum="2A289AEC83623FF3" modified="2017-01-18" version="1">MPPQPAHHGGSKYGASMGHPGGPRGGKQPTKLEIDSLPSMDKPSYYDPPSSPDASSSRSASPPPPDISTNSGNKLVSGAQFARRGKMYAWGPSFEATKTDQHARKRLKLCLEQFMPGAAAECNAEVPANIVSAEEGRGHRKRKRNEEREFVLPHLRSPSPPISTARLTSLLALPQNYTDVLLNPAMRHSLGEDGMEQGLQRTAGELLEGEKPLLQALGRLRDVIRVLNRDVPEAAPSTQNGVTEEVNGHDTLSQSYPHHIPPLPNISETDNLWRVTQELLSQSGSAQTLPPPTLAYTSTQPGAAAPTPNPTSEPEPEVTPLQRLFTCPTGITLHAVPSPGHPGYNYPQGHTLHPQTIKYNIDMRNQCRAVDDAWERISELLADCNEYRERLEEARDRVADVARVKKKVWRTVKERAAAEMENGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IR91</accession>
    <name>A0A1E3IR91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029753.1">
        <property type="nucleotide sequence ID" value="XM_019178315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IR91"/>
    <dbReference type="GeneID" id="30195461"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="183" mass="19989" checksum="0AC7A8EAC0A40997" modified="2017-01-18" version="1">MQTHGTNPNDQAPSHLSRIQAALVDCQLWVVDFEGEIGCVGIVAPPGKGLWESAEQKKLRDNAMSTVSPAAKRWLETELDPHRQSKSHLPGGATASYYLNALGTHPSFQNKGLARALLGKLEELARRDKTRVALVAHSDRAAKIYQNNGLRIIYHAVLRFGGDLGEGPYYLMVNDCGLSTEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRZ7</accession>
    <name>A0A1E3IRZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030010.1">
        <property type="nucleotide sequence ID" value="XM_019177971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRZ7"/>
    <dbReference type="GeneID" id="30195110"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN91384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="49329" checksum="C5887390EC67F1CB" modified="2017-01-18" version="1">MSASSSSSHVAGGSPRFIDNNHLELVAVIGTGAYGVVYLAIDSRYGQPVYRAVKCMRRHGLDERQRHFQRREIGLHRLASKHPSIISMDRIFEEGEYAYVVMEYGEEGDLFSMITDKHRYLGDNELIRSIFLQLLDGVAWMHSLGISHRDIKPENIVCSQNGTRVRICDFGLATSEEYSSEFGCGSTFYIAPECLGDWFPDRKTYPTRSGDIWSLGVILVNLVAGRNPWRIASPADESFNSYLSDPNFLRRILPVSRDCLYILNQIFAINPEERISLAELRKLVVEIKTFTMDQEEVIEAHVAARQKQEYATAEPRTLLSVVEDEHAWLEEENIEGHFAYDDEMETPSLQSDTGSPLYPETVSPCQSYIGDFMPPTPEFASEDYLIPSQVTPSWDDCLSSDDVFIHSKDGSCPTSKVSIQHTAFVDYSFPPVSAFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS12</accession>
    <name>A0A1E3IS12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029995.1">
        <property type="nucleotide sequence ID" value="XM_019177956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS12"/>
    <dbReference type="GeneID" id="30195093"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="247" mass="26923" checksum="8EF7431597596EF4" modified="2017-01-18" version="1">MATPQHQPHVSEEAIELSDLRKSSSAIPLVPIVSYHCTNDHKDIEPIAQYVLPPVDGGKKESIFLVAATMIAVLVWGILFAVGVLLAFWTSTLFPNQSSSTLTLVAKLQTGLLYMNSAVIGPFLTAVPRWQRTFQVMGILAASVALMASAFSSKPWHILVTIGLLYPLAVRLSHASNLSEEQRKALESVPSRSRGSASTPSRSAQSQSNQSMFQPSFSNQQSEADTMFSSFSRMDSGDLEERAPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU20</accession>
    <name>A0A1E3IU20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030221.1">
        <property type="nucleotide sequence ID" value="XM_019177837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194971"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="814"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1777" mass="190846" checksum="DBD2D4649382946B" modified="2017-01-18" version="1">MSSPAHSPPSAIPRAVSVSDTVRRFEARSGSSIPTRIVSSPASTSATLPARTPPHSPRKNPLRNSPSSNRGSPSYRPPSEAAQPVASTSTATSPPKPRELRLGNPRDERRASETAGIRQRGQGVPSASRLPHSVSLPRDANLIQPEPDDFSPRSETSSQSGFGYSPSRTRLRPSISISGVTPERCMPPLRRRAEKSEGMIRTGSADRILRVKSPPSSTSRQSSFTQAPSSAPSSQYFTPSPTTNPLTSPMSGSYDEEERTDLIVDGYFSLGDARNTVYLDSPAISSPPSATDPYQEREDVEPAVNSDGVPTLGNVVLPSDLSRQLSSRPVLHSRSSSASSLSVNGTSGHAGLRRGSSGIASPSLSRSGSHSRSNPPLSHNIPTTVIQEPSPRKSPRNSPQLRINPPALPSSAKLFNAISSLPTPPVPTKSPLRNFSGRSSVVSSSSRRSGGEGEERSEASTPHKTPQRDGNHAQERVKKVGSMESVMAVAGTPLSAATRMERMADVTTVESPVKSPLTYSSPPAMTESDRSSSLAEVESPVGYESAAPPRSSQDDRRGSSQSQNEIRFTMLTAPSIYSQSSASGSNYDSGPGSAKSWGTEGTTTPRSAESRFFTASTSSNPQPSPSGKLGTERPNGHELQKRRPLSGVMDHIHVGGWGKKKEEKEKGKESEKQRRFSNGSEKGHRRSSSLPRPSFSMSSDNDSPYANRPSFETRPSFESRPSFETRSSFEKRASFGTPNNSSRHLPPTTSTPLASIPQERSPAKSPSLPILRDPSFPTIATPTGAATGIGKKRAETSKESLSSLLSGTQTAKSKRSHVLKEIAESERAYAKDLALVRDAFMMPLNLQIGDARPDSMVSFSSSTSSGGGLTPGTPSTTARPGHSKRSSIYTYQTAETSRSSTASAGGPPSATSIPKSPSEGFNMGYFSNKAKSRESLVSFNTPNQAIRTSGIMAPPVGKPLSPADIKAVFLNLDHLAAVADELATRFEEALGREEDEEEGAGKREGEKGDDRLGQVFVAMVPKLRPLYNYYCSRQPSASRHLQTLLSSPLYALHLKAQWAVISPHTHAWNLDSMLIKPVQRLTKYPLLFEDLGKVTTPVHGDYFGIREAGIESRKLAAEVDEGRRRKEVVEMALSNGPAVKKPVGTDKKEAKPQGSKLLGLKRFKKSSVTTSASSTTLASASTGPTAPSLLSDSSLHTLKTHQARLQIFNTSLKTLGQDILLWTASAKEVLRAEDAVLRAWDHVGRLEEGDRADHRVLEMRNVVDGLVDGAWSELSVEIKTQILPILSTLLKSMTNPSKVLTKRSSLHADYTKYHSHSSAPLTKKLVALEPNVVKNAQEFVALHEQLLEELPDFLEGCMRILDIAVVGFANAQARYFSNIRVRVREFCLVWVKSPIGVGIYEGADGTRSSDEQMTGDDLEKAWYECWKGCAAALDKFQCTQSCNRTTSLTNSTDLPSPTLRHSASTNNALSSPTSLFFGSARGDRLSGAASSSGSAGASFIVTSPGGKEDKREGGGSRFNLLRRSNSKSAVPQLTTPSKPTHTRQGSGLRPSSATSESSRRSWGLPQIPNTTSEGFKGLGLSPTNSLTVPSLTNGSLVSPNPSFGFGSSGRTPEFGKTPEMGTPRSGISGYFTSRTPDLNMLSGDRHPYSRGDVPMPMRSPGRRGSGHPFASPTLPPGAAEPGDVSDGWREEPMLYQCACVADFDPMELGNRRYRGLKFLRMLPGDLIDILHEVGRIEDLPLFPYPGVGVENDGVLVGKGEDGEIGLVICSFLEPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVM4</accession>
    <name>A0A1E3IVM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">L198_05463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030297.1">
        <property type="nucleotide sequence ID" value="XM_019177546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVM4"/>
    <dbReference type="GeneID" id="30194676"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="315"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="740"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="563"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="846"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="968" mass="107327" checksum="314FE6CB4EE63EC2" modified="2017-01-18" version="1">MPPIYVKPENALKRSEELLALGTPQSQQQAFENLIEVFQSKRFKQTPINVLEPIVTKFIDLCVLLNRKAHAKSGLLVFKSAAQTTNIAAIERVLNHFIAQAETRLADAVEQAKKEVAALPDVPVVDDDLPLQPASLMLDTFVDSAGDRERIERRLIAPAQKYCWDAYDICLDIAKSNDRLEIIYQSIAHRAFKFCKVHERKTDFRRLCEQRLRKDLANAAKYSHQPHAINLSDPETLNRFLETRFLQLQTAVELELWQEAFRSVEDIHGLIAGRKGTKASMMANYYEKLTQIFKAEGGKQTAVFHAAAWARYFQQAERAGIVSDKASGCVLLSALAVPLGEVEVKQRLVALLNLPKMPTRETLVQDAAGKHLKRVPVDIRQIYNILEADFEPTTAAKVLAPLITSLAPAYQPYLPALRDVVLSRLLQALAQVYDAVTLSHILDLVKPLDNTPWATDMPSLEKFLVSACRRGDIRASVDHVSKTITFASAPADPTHLQSLAVCLYNTVNYLNPVPTTSRSDAFAAAIASAEEERKLASHKRQIVIRRRELLEEARLRRETAESTALAERLKAKAEDDARRIKEEAKQAEIDRVRKQINQTKEAEAKQLAASLAAQGALKVDISSIENLDSSKLVAMQVEQLAKEKKGFTERLRIVGKRVDHLERAMRKEEIPLLTDDYERQKAEDRAVHEQANKLLREQAIEQQKAAKELKQRLGRMLDDYNQLKAVVESQMEDELRVAKEEAKKKVEADKARVREQIIQRKREEKARREQEAREEEEREQAEQAAAAQRAEEEARKAAERENAAAEAAVAAEKRKAEREEQRQKDEEIRRKQLEREEESFRRRQEAAAAPPARASYRPPGAGASPSASPAPAAGGGSWLERRKAMAAAGGGSAPSPPPAAVPAAPAPSSSPAPAPASGGSWLERRKAQAAAAAASGGASPSAPTPAPAPAANGADDAKPGVWRRRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWH3</accession>
    <name>A0A1E3IWH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05723</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030185.1">
        <property type="nucleotide sequence ID" value="XM_019177801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194935"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="307"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="658"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="916"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1455"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1392"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1503" mass="164740" checksum="F4A85F4D5E38959E" modified="2017-01-18" version="1">MSDDDYFGDDDLFLDDSFLRQVDTIAAKSIQAPHPPTPMPVPRPGSSRQSNGIARAASLNEATASGKGTNANGVQRTYSAPGLKTGPASKAAVGGQSRLQTTRAADDPSSDDYGAWAIPEDALAAVVDEASSNLTNAGLSYVSANSANSASKRNTSGASRPSTSNNRTTSGPSQANRQDGMFQTHLNWRPSPKYTEGKRWDRTAFAKTGRRLIALPGGNDMRKKAKGKGKAKARDSENVMGWDEDEEDAYANEEDEEDMGGMLAPPPKSNFDLTKPYGPQKHLPNSLSIKEYIYPTNRSKRDYQFEIIRNCFMDNTLVALPTGLGKTFVAGVVMLNYYRWFPTGKILFLAPTKPLVAQQIEACQMSCGIPSKDAAVMTGQSGTKKLREHLWEQRRVFYCTPQTVENDLKNGIVDPKDIVLTAVDEAHKATGNFAYTTILSLITAHHPYFRVLALTATPGADVEKVQNVVDALHISRIEIREAEAPEIRKYMNTKHIERHIISMTDTIVDFRDRLGELMVPIVKKLVDKEVLTANALDVKRLRPFAITAKRAEFAKRRQQGMQWVYGPLGQVEKMARAMQYLLEFSLGMFATNLGEILTGKSSTGKKANTNGGANSLANNFAAQRLQRDVDEELNSIKIGRNGKSATDRHPKMAKTLELLMAHFAQAEEEETTLGQKNDTRAMVFCSFRPCVLEIVDMLNENAPLLKATKFVGQSDRDGDKGFNQKEQKKAISDFKEGKFNVLVATAIGEEGLDIGEVDFVVLYDMPRTSIKLLQRIGRTGRKRDGHVHVLMSENREDCNWDTAQQTHRDIQEEILHSRNLELFEDVEPLLPDRQLPGCKEQEMAIDEWNPDDQVFKKTMMDAEKEAKKASAKGTKGKRQNLMKDEVPDGATGFKSVKDLLKGKSLLQAVNAIAMRPESDDENEGPVLKKSKAKNPVKPRKVARAPSPIRSASEDDIDDQTLEALFAESRYSEKGKEPTGLKRKAAPVKRADSRHAKKGRTSDSDLSLPRPADLPEPQNKEDEADTARARRQQVIRAALAGRTPQATVPDIGSDSDIEALSPPPKAPFKRSCNSSESFPSIKVPPTSTKVEDLDFFHPAGPRRRDPSSPAKSLSPSPKKRTKYGDDDQVMVPSSSPASASRTLGTNRNKLSPGTAAAAGFSQIDPIDLSWDLDDDSESAPLPMRPVVPPAPRDSANDSFLPEVLSDWQPSSPPRVHRTPAGKVEMPPPPVPSTTKPTDGLSSPFGDPSGTSTPLGMMATQFPVRRLGVGLSRKRLVLPSSDDASSPVSAPRPGTLASVAGPSRTIVEDPDSSPMVNVGGRRGAGRLKRRVYVDEPESSPPAAEASSRQNPNRRRTDHNARGKRVKKKNKGPRGAFIENEVELSGSDSGDTSEHSTSSVASSSDLRFANDFAPTQAQKGYNQQAMYRAGLGTQARGHGLAFRRDFAQDKQHFMSKAKKPVYITDDEDAGQGRSSENEYEFGSFVVDDDEDVDYACRLPLIVIFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWI0</accession>
    <name>A0A1E3IWI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030412.1">
        <property type="nucleotide sequence ID" value="XM_019177661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWI0"/>
    <dbReference type="GeneID" id="30194793"/>
    <dbReference type="OrthoDB" id="10278266at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12377" checksum="9B46E7ED6E3496DA" modified="2017-01-18" version="1">MVAFGCVPLPRAPNPVVTTDEGEPLILPPLKFDGQKAAADRHSSQIFMADGDMVLARRLYHSSYQVFHLEASQGTLDTLRAGTLLIKFASLVGYRLEACSLVSYIVRKAQIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY54</accession>
    <name>A0A1E3IY54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic spindle assembly checkpoint protein MAD2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030583.1">
        <property type="nucleotide sequence ID" value="XM_019177430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY54"/>
    <dbReference type="GeneID" id="30194556"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="25117" checksum="E389401C5B00D943" modified="2017-01-18" version="1">MVQPGMSYKEIGDALTSFLEIALHTVLCIRQIYPPTTFTRRRAHGVPVYQSRHPTVRSYIAQVIASVGKEIQEGRLRRMTVVIKSVRTGLPMERLIFDIGYIMGLEGRKDIGLTGAPNADELGLMLRGFLVKLVALDGQLRENKDECTFAIVVETNDDLEPSGNSTADVGPWVPALASDVLQHAEGSDKSLEKHEPLLSIKAVETGVIDIRLMVQECVAKTGVEDLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYE1</accession>
    <name>A0A1E3IYE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin POM152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030550.1">
        <property type="nucleotide sequence ID" value="XM_019177397.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194523"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="38"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="182"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="494"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="593"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="804"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="914"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="139895" checksum="C6AB335144530D2D" modified="2017-01-18" version="1">MPPRIGTPIRRTQPPPPPPIPAALPPPPLIPTALLAPNEQRLFLVALVGLVEITKLWDTFLPLFVTDPDPTWTTSLRISGPVTVLAWTGFEVLALYFISLLRIPLLSPSFKQTTLLGAICLAINGLCWLIVEPSTTLGYVNVVGTAALGGEWYWNWFYASRKWSEPKHIQGVHKIRLLPYSTATLNPLLLTYCIPPDSHQPLHVPIVFNNSIPELLDIVVHPLSGGAPQTKTIYGSSLTRSPARAVKLRITDGTGDDDDEAEELEPEIDPLSALVLQSGKKIVGHPRDIDPASVPSVKPADSLALIPRNLAPTENVLFLKVDQPSVITLRNVVDKRGDRFHLTPRREAVIVSCPSGGKFVEQAKGGKLVLKNDKDQAPELRCVGDEDVVTFEATGVSPLEVKWEKKRTNANGNTAVEKTGTVEGIEDTLFSDSADPTTRTRVSKSHHVPLRVSHDTPGQSTVQLLSVKDALHNTYTPSGYSAQKAWKVETKKSVKFNCQAPYQLLQNQSVSIPIEILAPDLNHPSQRLERPLKLTYTFTPTSGGEAQERVMEVKSKKEELVVTEAGSYALAAIEGDCVGSVMEPSRCEVQVVPLPTLDMSVTTLHECAMDVGSTAHLDFTGAPPFKLEYIEQRKGGRPRTISQQFSGHHGSIVLRPEQEGAYTYTFTALSDRRYRNIQVTQPPIKQTVHPLANAELTGKLIKPTLYSCSGDVVGVDVEARGIPPLQLTYLTSHGTHSSNTTISLSLGRTNLQIPVPEALSSSNPSASGKLHINLLSIEDGNGCVRKLESAKSVEVNVKREKPSARLASGGSKQVREGEIVKVPLRLTGERPWNVVYEVDGKQQKVTLNDPNAAIQLKSEGVHKLVKVNDATCPGEILDPSSTFTISYLPRPSLAILPSSALVLAKKSWNHQGLCAGQEDQVGLTFGGQAPFELTYRLGKDGKDLGIRYLKSAQDAGVLHLETDPGTYTYQFITLSDGNYPSNGLDQKISHQVFARPGGGWIKGGSSGPLCLDGKLESGAVLGLRGKGPWQVTLGVRKPASAKVDLYTINTAKPEWSLSLPDVLLNDIGRYEITLHDIVDSSSCPMELLDGGEDGTGFRDETRISVEVVESARIVEVDARKQVCVGDHLEFLLQGKAPWTIEYAWLGKEHRVTSGGSRFSRFAEKAGKFEVKSVALRGDQCKRQVEGMVRTVHPLPSARIKSGEDDLREGDEPAVFRVYFTGTAPFSFTYTRSEQSGSKWKVVETQTVTDIMEDSYAISSSLPGDYEVTSISDKYCRYPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYQ1</accession>
    <name>A0A1E3IYQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030458.1">
        <property type="nucleotide sequence ID" value="XM_019177707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYQ1"/>
    <dbReference type="GeneID" id="30194840"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN92831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="37649" checksum="82D86F697C29C4B7" modified="2017-01-18" version="1">MPPAKPDSSILNPILDNTQVPHQALLVVRDPVSFSGRPVFREIIRRALARGETITVIGILNPPEDYLPLHAPGVNKLDLTGSVPGYSSTNTASDIKKQILSTYQSGQIFIDALDVLAEDYSAASVVSLLRSLLGTIKSLKAPSRLVLLLPSSSVLSHITPPTFHPTLTLLTPHPPPLLTYLSKLYLSPISSSPSANFWMILENATKRQTGKELALRGEEGLEVSTGSSWGDGSGCVQVLVRKATGGMKGISRSLEALSPTSSQFLSTVPLSSLVPLNPLRHSSTGPPPTANTPSTSTAQTHAELDLPFNLSLTDSQRRQRDSVPIPYAHEGEGASGDLVWEDEEETDDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZZ7</accession>
    <name>A0A1E3IZZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transformer-2-beta isoform 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030700.1">
        <property type="nucleotide sequence ID" value="XM_019177119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZZ7"/>
    <dbReference type="GeneID" id="30194233"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="219" mass="24123" checksum="1919E25F750598BA" modified="2017-01-18" version="1">MVRLSSLPRPAHIPSQAFSAAYVPSSPGPWENRLPYPGYIAYPSSAPSRSSPGSYDNERDELQAEIDRLMAYTANVRSPSPSDSLVEDDTYTPPKPSNAPDANPTNILGVFGLSVRTTEKDLREEFSLYGQVEKVVIVYDQRTGRSRGFGFITMRSVDDASICITKLNGNNIHGRHIRVDFSATRKPHDPTPGQYLGLQRAIRKSNPSFQVANPALLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J025</accession>
    <name>A0A1E3J025_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">L198_05050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030730.1">
        <property type="nucleotide sequence ID" value="XM_019177149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J025"/>
    <dbReference type="GeneID" id="30194263"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="366" mass="39266" checksum="C16E66D1D8276620" modified="2017-01-18" version="1">MSVAEVEQDLSHIHWSWPEAVAANPARSLATADLAMDYFAYSPFWDSRSNNNVLRTQRRIDNPTYGHAEEKIELNAFMSGFEYIVAHSQPPNMFVIHRRDVESSGKRDHVTGAWFILQEKIYQCPSLYDVMSARLKNATSLISKTMRTLSDNRPPANPRTTTLWRSLPPSTSKLGPSSNQSPVVENDHAEAPADSPRELDLGEKPAGKTKEQVQEPDWHLFYALQSTRASLASLTAMSRAPGKKPDPKEELKSIEAAITQQLGGGGGQESVTGRSVVPRIAGASGAGSVKGLGVPKAGSHLGAPAPQGGWLGATPGQGTGSPATLPHGVTPDMTGSPARFLNEKLVNQHGVNGQPPHAGASYIGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J056</accession>
    <name>A0A1E3J056_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030760.1">
        <property type="nucleotide sequence ID" value="XM_019177179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J056"/>
    <dbReference type="GeneID" id="30194296"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="17009" checksum="5F5695E5DD5EA5D8" modified="2017-01-18" version="1">MSEYAFRKINIDALEEDVLLPSDLYDPDPRGPDGVLADAQSRSGEVRSLVSRGDIAGALGTILTDPPYGEGVDEAKALTTNSLLLIFNSTRSTDIPALVKGLDHVQQDRLMAYLYKGMAALGQGSGDTSGSVLLTWHEKLTEAAGVGCIVRVMTDRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J083</accession>
    <name>A0A1E3J083_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_05149</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030824.1">
        <property type="nucleotide sequence ID" value="XM_019177243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J083"/>
    <dbReference type="GeneID" id="30194362"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="477"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="885"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="985"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN94293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1165" mass="130043" checksum="6DE6BA907D1DBAA8" modified="2017-01-18" version="1">MREEPSPEAPPKTSSPGLFFPPSDSEGEDSSYTPGRATVAPKAARSSKKSTNTRPKPIKRGSSSQNQSDVVEISDDDDDIAIVKAPSSSSGAASRKRSRRGSQSRDQNHMPTAVIPSGFKSGFLGEFVCEGWSLSKGRGYCSSGTKIIIERNKPKDSNAAESSKKPKGGETDTGRVRLVGGKVVGGKAKPKQTTLASTMNKKAGLPIRAKAATDQIIRFRNERGFEVGRLSVTEANFLTHLLDTGIINLGGHVIDCPEVLTTGCTILLDIKVHLTRKAFQNSNRYERTEQGTFWKDRQETVVEEAMRFRKDSLAKLFERIGVKPIQTNALSRVPQINSGGVSDEPKAKKVKAISDAKDSGKGRERDTGEDSGDEAEVLDDKQLNEIDNIYRKAQQGDTRLDEMDPPETFLYTLRPYQKQALTWMNARERGDQSVREESLHPLWEELPIEISDDEDGPDPSRKFYWNPYSGELALQFPTSKNLSRGGILADAMGMGKTCMMASLLHTNRETEDLAKEQGAEKQEEEEVEPASKRTKFKQVTLSNQWRAIPSVPKPSPRARATLVVCPVSLAAQWHEELGKMSKEGSINSFMWYGNDRTDIETLLSGEGKDQVDVIVTSYGTVSSEYQRWVKMKERTNYEGGSLYDHEFLRIVLDEAHNIKNRTAMVSRACYELQGQRRWALTGTPIVNRLEDLYSLLHFLRITPWGEYSFFRSFVTVPFLNQDPKALNVVQYILETCLLRREKTMRDKDGRLIVDLPPKHVAVKVLEFSRPERQIYKFLEERAKKKIIELDADGRALANYTSILAMLMKLRQCVDHPLLVLGKSGEDSELAEQILDSSSADLTDSLRNMIAAYAGGARAETPEDVDQAYAAQVLKELGEQEETPICELCSNEMFDEVLLPCYHRSCQDCIVEWIGTCEDQDKPANCPTCDKGPIKLADLRSVQRRHKRVNPITGAHPDEDEKASTSGATAISLGKVDLVASTKLKALARRLAEVRQEDPTYKALVFSQFTSFLDLIETTLTKQGVKWLRFDGSMSQAQRAGTVMEFGNKSAEPVVMLISLKAGGVGLNLTMANHVFMMDTWWNEATEQQAVDRCHRLGQTKPVYVTRYIIKGTVEKRIMKIQRSKTALVNASLRGDAAKSKETSLADIKKIFGLLDAEEDSEEEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0D7</accession>
    <name>A0A1E3J0D7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Auxin-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030850.1">
        <property type="nucleotide sequence ID" value="XM_019177269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0D7"/>
    <dbReference type="GeneID" id="30194388"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19093">
        <property type="entry name" value="AKR_AtPLR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="309" mass="33942" checksum="42B1A9170818BF57" modified="2017-01-18" version="1">MSLVKTVTLAGTWAWGDSTWQYTPKDLENIKDAWRACLKAGLVFFDTAEIYGAGESERIIGRLIKEETSEEDKSKIFIATKFLPVPHPKTGLFFFSPPIVERLKSSLQRLGLDSVPLYQLHSSISLHSHETLAAGLAACVKLGLAKAVGVSNFSKDELIKMDELLKKHGVTLASNQIEFNLLRQLPDQNGLLEEMKKRDIACLAYSPLAMGRLTGKYNASNPVPSGRRFSAQHSWEQLEPLITELGRIADKYGVKHSAVALNWVMSKGAIPLGGARNGSQAEQNAQATTFELTPEEVDSLSKLGFSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0P7</accession>
    <name>A0A1E3J0P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_05079</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030756.1">
        <property type="nucleotide sequence ID" value="XM_019177175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0P7"/>
    <dbReference type="GeneID" id="30194292"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN94225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="124" mass="13544" checksum="5E439697AF7E811A" modified="2017-01-18" version="1">MSNRSSELNLPPSLQNLYQKQQEYAGLQALREASGDLVTRAEKLSEMSNIMADGGEAIGGVLRNWPHVFSILNLFATQMDQKPDSSRTEEDEQDPIPCLVRLPYGGETTSAGATSSEGEDKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1S5</accession>
    <name>A0A1E3J1S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031102.1">
        <property type="nucleotide sequence ID" value="XM_019177070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1S5"/>
    <dbReference type="GeneID" id="30194183"/>
    <dbReference type="OrthoDB" id="2930561at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="60695" checksum="7644FB7E38932B4B" modified="2017-01-18" version="1">MTSTHSSPLMKERKRSAHWSGQDTQILINVLLREKDTRTADNGFPPEVWQEVSGLLMGSNPNLAQDGSELLLGGAKTPEACKSRWQRLQRDYKAAKELAQLPDITWNNATHRLEATEHAWQNAAKVLTTSRHRKIHLPWWDSLVILCSKEATRSRGRRRRKKSIEADQEEYQAELLAESSRHAAQVHAQMTNGHGHHGYDPMSNGHHPHHHHPQEHHQQHLDGMHDPNQGGSGLVDLSNGALQAVEHGAFSWEAGSSGDGDFDQSFLPNQAFISQKRNPMFDPSLLTPETSSATTVSAPLTLQDTPNKRQRTSSRTSQTHVLPHQHLGNMPGANYSYAPMASGNQTATGPGAQSPEYGSGEGLLDPVLLQATASPGITLKTYTPPEKGGPATTMQGSLGNPQVGRRAPSQSQPQPRHPLTSHSSSDSSSTHNNLQIQAQAHNHPQSRPHSQAQSQPQSVHQPHLTQIQPPFQVSPSDPMFLSSLTESQRRTEALLQLQTIDADMRDEDMVEVMEEFEMNVAAADTYLAIKKEALRKMWLANLLKRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3A6</accession>
    <name>A0A1E3J3A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031314.1">
        <property type="nucleotide sequence ID" value="XM_019176839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3A6"/>
    <dbReference type="GeneID" id="30193943"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="90"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="46884" checksum="75188A012B30829E" modified="2017-01-18" version="1">MSDSEEDFMSDKFLLNLPPPPSSSSTSNTYTARREKAALTGNRSGLAKNQLKARDLEEVRRREGMGRSLFEREDEDEAEGGESESQGGKKGNKAMEMMMKMGWKVGEGLGKKRSPSPTPPSHASSARAGLGAKRFKPGDELEDTPPPKLQPITEPIRVSLWARRKGLSAREPSPPPLPLNPSGRNPDALGKEQMERLAKEADGFRARQGHEWGERDKERKGRKCRDLLVGYDKEKGFHALHVLPFDPLGTMPRPILKLIYPAALSPSPSPSASRSGSPLPNRVAHGKEENKSQAERLRKQMRRDMLSDIDGAEVGDDEEKDVRFGVGPDTAPKREQVEDEEKKKGEQVEEKEDYEGVDWEEHVAGTKRVLSMEPGEYLTFIVNQLRHEHLFCFWCAYKYSSWDELEGPGGCPGEEEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4G5</accession>
    <name>A0A1E3J4G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031398.1">
        <property type="nucleotide sequence ID" value="XM_019176470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4G5"/>
    <dbReference type="GeneID" id="30193564"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="105"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN95733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="227" mass="26633" checksum="516BD515C3C1EB98" modified="2017-01-18" version="1">MEHSQDDAYYQQQQQPYQGYQHQPAQQPHQFIDYQQQQQPQQPQGYVDPYGYHQGIAVPPQSPPVQVTHSPFVRTDSSQNVSFSEMARMAGRPQTFDEMYSVPESFLEIEIRNAMTHGMGRKMYTDYEIVCMTNIPAFKLRHSVVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFSDEVIEQRREGLQRFLEIVSGHPLLQTGSKVLCAFLQDPNWEKSQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4K6</accession>
    <name>A0A1E3J4K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031447.1">
        <property type="nucleotide sequence ID" value="XM_019176519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4K6"/>
    <dbReference type="GeneID" id="30193613"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="17699" checksum="AF5AB94575379CAC" modified="2017-01-18" version="1">MVFRHVWGWMSSPRKPNLNLTPTSTNSSTSSQQSSRSGRLDEQAATTAAYIVCPRPLPSRAFSDEADTECPICLDEMELVIFAPQPSELRGKIRSLRKKQTYQQAVETPVDPALHTSKGHVVAPCGHVYHYRCLKGWLEIKPLCPLCQDKLPTLSLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6C6</accession>
    <name>A0A1E3J6C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031654.1">
        <property type="nucleotide sequence ID" value="XM_019176244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6C6"/>
    <dbReference type="GeneID" id="30193335"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130154" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="109" mass="11865" checksum="C417C50089CDDC2C" modified="2017-01-18" version="1">MPLGRSLALLAALATQAQAYDDLLFTEDFFPLINARLDPIIFPGQVSAHVHHVIGSSAFIASEFFEDSQTANCTTANLIDDLSNYWSPMLYYKWKNGSYSAITGDGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N1</accession>
    <name>A0A1E3J6N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp71-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031748.1">
        <property type="nucleotide sequence ID" value="XM_019176338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N1"/>
    <dbReference type="GeneID" id="30193429"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="587" mass="62289" checksum="0E1E394B7075AB82" modified="2017-01-18" version="1">MTISSYTWSCLHKKSILGINFGQSYASIAVIDKEGHPTCIANEEGERQIACAISYAGEQVYIGNGAKPHLVKNGKNTIMGFRNLLGHSYDEVDHTAILTAPLISTSTTPAYTVDVLIPPPAKGNKSGATSGAATPAAEPVASQKTLSVPEVTTLFLSTLFTSATDFLGTKPTAAVISAPSWFTAEQKDALRKAAKAAGINVLQVLDEAAAVLVGYRTGLSEERKERGLLVVVLDMGETSLNVTVAQVSEGEYTVLAKGQDDKVGGREFDNLLLKHFAKEFTKKTKIALDLPCGESAPDADKRAEAKLRLAVEHTKRSLSASSGAATCAVESLKDGYDISSSINRLRFDGLAAPVYRKISAVVSNIVKEADLDLAQIDEVLLAGASTLFPGLQSNLSYSFPATTPVTATIDPAEVIAVGCALEALHLSTLSDGLKIEDVLATAAEGKVDTTSAPIGIVLPGQEANTLAAVVVESGAPLPVRRRVAIPAPAGKVALELWEGKHEVNVDLIQPPPREKDEDDEDDEDDEEDEPEEVKTAITVKTKALGAVEVELKKENNLVLEVIVQRGGGLEVRAWEEGREEEADKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6P8</accession>
    <name>A0A1E3J6P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Man1/Src1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031783.1">
        <property type="nucleotide sequence ID" value="XM_019176373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6P8"/>
    <dbReference type="GeneID" id="30193465"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="399"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="781" mass="85893" checksum="F7AC94D1FEA92C7B" modified="2017-01-18" version="1">MSAPPPETYLAPGFNPAKLTVPQLRQVRSVLLAHGHGYSARIKKDELVREFETHIASQASALRRQAAAVVPSDAGIVSVSDAGEETPAVPTKRPRRSSRRSTAEPESTDVELPDQTEVTPEPPAKRSRSKAKSVPVVEIEATPRRGGKKNGQPVIQVEDVDEGVDGKIEDELPKVAPTPSRRTTRGRSSMTPVTPATEPPTSARTPKVPRSARKSEPAIKVMENLHEESERDDTPKKKTARTPRRSAGDEPAFSDFNPFQSGSEAAAEKARRRRKSSIGFATSTRKPDQPRYSEPGSDAVTPPGILRRMGPSRENLRTPPSEVKRRLAEGDLDDAVAYNHEVQNKLNQISRNAQEDAQVVVHTSTDAATDTEKSLATRVNDQITHNVPAPRATLPLSVLFLLLLTFITNFKSQSSSIGFCDTAYSSNEIALSRLSSRTAAEKCLEERARLDATDRDQAKHIQCDTSNLPLVPFLPVPFACTPCPAHAQCSNGEIVACEPEYLLSPSYIAFLSPLVDGLPTVGPRAFPPVCKPDTRLKRLIGSMAKELESSLAQHRGDVICEGTGGGSDGERFGEEEEALREKYAGMRRQGVSREEFDQIFEAAIKDLVEHEDLIVSIDVENNVTRYAAARTDLTLVCRGKLEAADLLDRWKSQLGSTAAVLTLIAYIRSEVSRRKEDKYRAASLASVALRRIQDQEQLHYTDPASTPNPFIPRDQLRDLVMPHKGATLGGSKARMWEKVVELVEGNANVTVREQEVKGEIWKTWEWSGVGERPIAHVTWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6U1</accession>
    <name>A0A1E3J6U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Di-and tripeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031814.1">
        <property type="nucleotide sequence ID" value="XM_019176404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6U1"/>
    <dbReference type="GeneID" id="30193497"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="748"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109292" checksum="9C8043D1DCC0E30C" modified="2017-01-18" version="1">MSLSDTRILPNLYDALASPPLSPQPAKSRTRVSPVTTHGYNTPLTSISPRPGATFKTAITVDDTHTPISRPALNGAVTDLAATTITPTPGTLSIKSSIPRSFQPTQQPLALLSDPANHTSLGEPPRLILHNEADSLTRERKGKMPVLSHLLSVGDGRVLCLAADENYVYAGCQSSDNEITVFSRSSLQPKYRLLGHQGSVLALLIIPEKDWLVSSSSAGDVRIWSTESLDLIYIIHPCDDTSGDIYSLAWDEREGGTLYYGSQSNSIEWVNFSGAGSSRHRTISASAASSIQVVSNGDASPRSAPSQRSGRYKPHKFFDNPPDGACSGVFTPASISVSGCNTGRTSVSPKVDLDRVDDGLLRQTQAATEIETAAESRLAFAHYGYIYALHIVSRPNGRTWLVSGSGDSDIKIWECEAGGGISLVRQFDSLSGGVLSFAYRDDLLYAGLQAGEIGVWDLETGARIRTIEAHEDDVLTMCALGGDVYTAAADGRILRVNEEFDCTAAFRVHGGPVFDCVVIPTQKEDGWQLVTSGCDSYVKIWQIEAPNVGLNHEEVDMGNEGDVMLYALSKLVAVPTVSDDAHRESCRQGAHLLKKILSQLGATSEVLSGEQGRNPLVLATFTGRDTGKPRKRLLFYGHYDVQPAVEERWETNPWELSGRNGYLYGRGVTDNKGPIMAVACAAASLRQRRELDVDLVMIVEGEEEAGSRGFAPTVRAHKADIGHIDAVLLSNSTWIDEEDPCVVFGMRGVVYANLSVESKEENLHNGVDGGATVEPMFDLVRVLGGLSDAKGVKVPGFYDSVRPETPEEMSLLRDVSAACGRPLEELIRVWRQPSFSIASINSSGSGNKTVIPRKVTADISMRIVPDQSLESIVQGLKEHCEKTFKSLGSTNNFNASHFCLVLESLLTTLQVQVTHTASWWLASLESPYFKALESSIQDVWGVKPLKIREGGTVPTVFWLEKEFGAPCVHLPLGQSSDAGHLANERMRLLNLRNGKKVVEAYLTRLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9W9</accession>
    <name>A0A1E3J9W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032067.1">
        <property type="nucleotide sequence ID" value="XM_019176154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9W9"/>
    <dbReference type="GeneID" id="30193243"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="35360" checksum="E4B373C4F53302CC" modified="2017-01-18" version="1">MAFSYYSRPRPQHGPPPPPRAQQQPQGYLYPDPSPHAALATSSPRFQPYARPAPKSHSPSSTYLGSPHTGYLPQQPSPHPSSAHPSPSYMQSTSAPSAFDPPSMPEPMPFSSAGYGVGDGLYDGTSSFPGYVDPNGPAAAAASESRSWENSTRDVAPDDYAQALALYTHICNSLPYYVPTSQPAPNSSSSTPPTTFDSIIGLASEGHSILSGQAPPSTSAIDIGSFGPSSGFTSGVESPEGRIGGGIASGSAAASTSAVATPVTAPASISSAGRKRRNSGRKEPAGPPPTCLGCGATETPEWRRGPMGPRTLCNACGLVHMKLQRKKRKAEEKERAAAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBF8</accession>
    <name>A0A1E3JBF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031853.1">
        <property type="nucleotide sequence ID" value="XM_019175940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBF8"/>
    <dbReference type="GeneID" id="30193027"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130227" description="Dipeptidyl-peptidase V" evidence="6">
        <location>
            <begin position="20"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="501"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="731" mass="81190" checksum="14879A1B05C5D4CF" modified="2017-01-18" version="1">MKRLLALAAASSALASVFAPEHLLAAPRPAPAIASPDARHALAVVDQWHPATDHISRAVYLLPLNATVATPPLSLFNTTPPAATDFLWLSPTTLAYLNDTTLYAYSIDLETRESGAGHNQKHPQQPTKLLTFPAGVNPTSLQYEPNTNTLAFTGQVWADGSFTHTAFHDQTYQGRRDSAQVYDELFVRHWDTWRVPGKVWTLGTVSLKGLVGKKGVKSENEFVNVLNGTGLFSQTDPIDASSYALSSKQIALALKPPYLSPATHTRQDIYLSSLTSSRPRNITPHVHGAISSLAFSPDQSKLAWLEMNKDGYESDRRVVVVYTLKSGKTERWTEAWDRSPSAISWSTDSDSLYLLSEHHGRTLPYHISHPNHLPTPLLFNGSTTSLTPLSESTLLLARQSLVSPSDDFLFTLPTDAPSEGDGDKIPPPSDPLRRLTSWSAAHLAGRLDNYTGEEFWFTGAEGKDVMGWAIKPHGWKPDQNASYPLAFLIHGGPQGAWEDSWSTRWNPAIYAAQGYFVVTINPTGSTGYGQEFTDAIQGDWGGKPFKDLLAGYQHALSRYPEIDPERTTALGASYGGYMINWINGHNDHFGFKALVCHDGVFDTVTTYFSTEELYFPTRDFAGTPLNNKAGYEKWSPVNHVIEWTTPELVIQGGKDYRLENSQGLGAFTALQVQGVPSRFVYFPDENHWVLKPHNSIKWHYEVLRWLHEWVGQANDQEEIERAQEATFAIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC03</accession>
    <name>A0A1E3JC03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032043.1">
        <property type="nucleotide sequence ID" value="XM_019176130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC03"/>
    <dbReference type="GeneID" id="30193218"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="492"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="863" mass="95837" checksum="88E7A79E6DAEC02B" modified="2017-01-18" version="1">MTARSPEPMANNTTVQNTCPNGGAAKRKVDDVFSSNGKGEEKENERAEKRQAVQAPCSSLVEIKNKKIVFKQAPHNRVLPRRKLINLETYLLDQVEEQKQVTEIPEEHWSIIAMAGHELTGATEGIFLKQLKTALNIPTDQDLLPNSVLTPLIRRLFALHQYGFLPSDFPPPPPRLPAHLQVRCWQVVDLPKYFPSEQLELLQARQEEREKAREECIGIMTSLDDVEKHELLGKKDDKDKETPAKVAAVPKEKPTSAIFSRASEGPEEAGSSIRGSSPVKMESASSPIKPGKTPEEVRPRSSCDGNGVDAEVKIEAAKAKKQEREEKKAVLAEKKAAKDKEAKKKEEATAKQAKKMSMFFKTKTTSAPKASPASSSSPQKKGEEESDYKRVFRPLPTKKHIQVAKENRWVEQKRSREDKAEEVEGWSSRDFINDHLKTHNHQSRIPRRIFPSGIKSAPINGSIADVWATLQEAEEPRDVFEQLKDRRRFPWKTLAFDHQPRPPYSGTFTKKSLLVGPRTPFAQDPVFDYSIDSGDEWEEDEGGEDVDDFGGGGEKAEEEDDDEDEEEGEFDDWLDDSEQVESGPPPPEVIDVDDPMGSVSKLPAPAKVAKKKEPVKRIVKLVPTWKGPLWETKIGEKGTEGLESYRIQLLNDTPAQIDPFTYISPDPAQEYKADYGIAVIGPNSNIKCLLSAELIPQKPPPSALPKDAPQKPRGVAKSSFPTELLADLYKMVEGDTRTAKDLVPALREQFGKAATKVAIEAELKESAMKEKRGKDDKKGKEKCWRVYREAWVAAGLTPPENAPSKPAPQPATVKRTSPSAPVAQLTAPTQPQSPMAPPPLPPSEVLNEPPTATESHEPIVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC95</accession>
    <name>A0A1E3JC95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-xylose-proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032326.1">
        <property type="nucleotide sequence ID" value="XM_019175836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC95"/>
    <dbReference type="GeneID" id="30192922"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="150"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="660" mass="74003" checksum="E0711AE3AC0B4EBC" modified="2017-01-18" version="1">MSEEDVTHTARGHGYKQRSQYPLTAAMVDGKPVTQHVEGGSEKPALASDNSDDHHPLARKKSHKVDLISNTNAKLANPLGDLTDEEVMENAAAFAAANNLPVEAFRKGGVLAKRPHAFEKLAILDEEDKARLRFEVEHPYRSQTWQLYNMVIACSVAAAVQGMDESVISGAQLFFPSQFGIGEPNINPQYANNHEWIMGITNGAPYLACAVVGCWLTDPLNHYLGRRGAIAVTAFISFVTCIWAACTNTWWHLFIARFFLGIGIGPKSATVPIFAAECVPARIRGSLVMQWQLLGYAADLMFYHVSDKPHITGLNWRLMIASAGIPALVVMAQLPFLPESPRWLMKKGRYEKAFRAMMRLRGNEVMAARDLYYIFVLLEEEAAIVRGRNRFLEIFTIGRNRRAMIGSTIVMFGQQFCGVNAIVYYTATIFSSAGFSEIDALLASWGFGMLNAIFAIPGMLTIDRFGRRALLLFTFPIMALLLLFTGFCFWIPEGPARIGLITLGIYLYCIAYSPGEGPVPFTYSAEVYPLYIRELGMSLATATLWLFNFIVSFTFPRLLTAFKPQGAFAWYAGWCVVLSILILFFLPESKGYTLEELDQVFSVPTGVHAKYQLYNLKWHFKHYILRSKEPHEALYKFDDDLVDDKEFFEPSKDGQVQHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF32</accession>
    <name>A0A1E3JF32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032565.1">
        <property type="nucleotide sequence ID" value="XM_019175462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF32"/>
    <dbReference type="GeneID" id="30192545"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="270"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="791" mass="88289" checksum="872D06C9E33EB703" modified="2017-01-18" version="1">MVADDPPTPRVTRATAKRTVQSPTPRSPRRSREATPVAGLDDPTLLNAEDSGQTELPTSQTEAKAGPSTRQVDAEATTSEAESVLFSEKTTVMPNDGIVVVDATARETHEGMDEYFMLEDNATTRNSAATTQGDQEFVPETTSSMAPLAVDDRMAMPPPSHTRPRRSTSINDPFTASTSDSGRPDRMTMVLEKQKKRSFAEIDLDESSPVAEDDEIMSDTSYHSGDSADFEMEHRPVLQRTAIKRDIKNFTASLELLTRGSTEAGMDIPYKVVDRLGEGTFSSVYLAHDCLHRVFDNEYWLGLPNLRTEAHNQRQIRVALKKILVTSSAIRIENELAILENLRGCRNVSQLITAFREEDQVIIVLPYHQSDDFRHFFKHMDPTHIRSYMRDLLRSLKDIHKRGIIHRDVKPANFLFDYEHEHGVLVDFGLAERYVPPAEPTCQHAPATLTCLHGSKIKTAETPAVEQALYDARKRSRLGEGRVGFPQEDKRPTIRTNRAGTRGFRAPEVLLKCPDQTVALDLWSAGVILFSILTQKFPAFNSSDDIEALMEIAAIFGKTALERCALLHNRTIISNVPSLDHPPASITELILKLNPHLYTPHSPNPTSAEAREHIEAIDDALDLVTKLLRLDATKRLTAAQALNHAFIAGAMGEYGIEEEDEVLHPSEGKCGELHISEEGGRHQAYFHPVFQDLQFGQGVPPSRDSLCPEHEHYQDRWSFNPLVARGDMQKSLEGDGEGAYSSDEDFIVERPSLPRSASKREGDRTLKERDVNSQQGRSVRGKGIGEEWVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF57</accession>
    <name>A0A1E3JF57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032590.1">
        <property type="nucleotide sequence ID" value="XM_019175487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF57"/>
    <dbReference type="GeneID" id="30192570"/>
    <dbReference type="OrthoDB" id="2585427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="58593" checksum="69A711FB164D8DDB" modified="2017-01-18" version="1">MGFFSLRKRSDPSTIPTPGSALSLYDHSSRSAFPLPSALEIITLRVAVDPAPTNQGAKSIFYVTVGLEESVAALRREIARSVGHSSMSLFKVAIPTQAHRQAQAYTAEYGKAVDLLANFPAFNLDDPQQLELSLPPQHRGLTPTFAGSPRDLKIRHWFPNHIAGDVVNVVARPLRGVPVNMKPLTLRVFLASPPSKCRPATMPETRQPPLVVDVDPYITVNELKMELLTASGNDSQLWKNVTLWQIAMTESEMTVIDELGRLMNGKMPWPYPPGALEPIALSDNSLPISLFFPKSAPNGDMLNLSMWFSGPISTPSLGAIPPFRYPVPLSLPGTPSRSISPGGYHSPHRSGLSPLPVQMDRAQSASPTLGTPVAELFSIPPKSKNQTATRGSRRPSTAPTVLASDFGASFSKDSVLHSGGVSELCPPSLSTSPSLSPRSIPSGIKTSLKLSAKGARKGLGIVIPSAYPLSKQLSGSDRDSFSSSEDETGITSLPSLNFSQHSLETPREFAVKTPVEIFSMKMGMVDVLPGLASPQGKQGPVSSAGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI84</accession>
    <name>A0A1E3JI84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032750.1">
        <property type="nucleotide sequence ID" value="XM_019175018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI84"/>
    <dbReference type="GeneID" id="30192090"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="14216" checksum="34029F5F44785C51" modified="2017-01-18" version="1">MLDKCDYLDDLIHKTCQHFPSMTASETEVRNALNQVDSLLKENPCPYFGHGVEKRTMPTIVVKDHLPAFTLALAVYFRLARSLRLVMAPISIRLEDGRSFGIAYSGNPIDLVEEEFQWCTNVIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLU5</accession>
    <name>A0A1E3JLU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033086.1">
        <property type="nucleotide sequence ID" value="XM_019174707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLU5"/>
    <dbReference type="GeneID" id="30191774"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="343"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="739" mass="79341" checksum="5E91D6F343F1ED96" modified="2017-01-18" version="1">MEPHISSPATDNLRPTLHKLAHSYTAPALPPDGPLQDNRIMSLVARGGKEAWRRSIGSFWPPSPTTNTASPPKKLRTQPLDTSNILYPTLTTHPEPAPYNILVVSLAHIASAPPSLSNDELFQVILRRLEPWVGEEGEGGYVLVIMSAEGAAATASASSASASAAAEPSHAGDESRKLPGVAWWVWKWKRIPRKYRKNLKRFYIVHPSLFTRSLLPFILPLLSPKSYSKLHPLPSLLALYYTHDVPLTGIDLSLAVLESEGRALRDHPELLECGPELADVQRVSSHDSSKSKYPKEGSDSYFSSISSTFSSAASYIGLSRLPSPKHSAGSRVGEAVVDGYWKRDLRGLVDECGGKVPPMVVRVSRAILEECTATEGIFRRSSNSSYMAPLQSLLALPLEAQPNLPWSALAQKDKLLLPKVLCKFLGELAGPVIGWEVYGDVRRVALPSDIPPFLNKLPPSHTLLLTAVVSLLHALAKHEPTTKMSALNLAIVLAPTLIGGPDKMVDMGMCLERGKKLPLGMRDCVEGRGRKGEGDGEGREGGGGEEGEEGDGTVVGLLEIWITNYPSISGGTPIEKMGCGVSSDFVPPPTSARASQAAASSSSPFPTSSLTFTSSSSPPSSSTEPASSSSSSSQTKSQRRASLSPSPPKSSPPRASSLARSASASIRRASLSLGRRGGDKVRDKDRVDLEKEKEKEKEKEKEKEKGGREGKEGRGKRRRSGVRHSLLTSGIVEVPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM52</accession>
    <name>A0A1E3JM52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033203.1">
        <property type="nucleotide sequence ID" value="XM_019174824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM52"/>
    <dbReference type="GeneID" id="30191895"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="35552" checksum="AA6FF386EEF296A6" modified="2017-01-18" version="1">MTIQTSKLFEPITLQRTGVPSELSIKYYKQRSSDGGLLISEAVDVAKEAGCYPSVPGIYSPEQVEVWKKITAAVHDIGGKIVCQLFASGRATMPGVTPVDYAPSDLPLQGDHPDLVVTTEEDIERFLKHYEQAARNAMGAGFDGEEIHRANGYLIDQFTQPISNKRTDAYATSTFLFPLRFTQVIVDAIGADKVGYRISPFSRFQEVREADPLGTFIPLVEKLLEAHPDLAFIHAVEPRTEGAGSVELAKATDSLDPIRDIVKQKGKGTNFIVAGGIEHGWPLTPYERDTFYTQGPVGYSDYPYYSLLHQEESYTFGVPQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMU2</accession>
    <name>A0A1E3JMU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033228.1">
        <property type="nucleotide sequence ID" value="XM_019174849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMU2"/>
    <dbReference type="GeneID" id="30191920"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39063" checksum="4E58F7DD95FF045D" modified="2017-01-18" version="1">MSDAKQDLVDASLLSSSHLTPIDHKSHPLSSWPSIKPNPIGRLSLLNPSITVAAARECIQVGKSFPIDWPVYQSGTCLFERPCGQHEIKRRGYGDDEKQQTDENGTPWVVCYDEILTINTQASSQWDYFLHFSYPGSGVFYGGIKDQDILNRKTGDFCVAALAKAGGIQTRGILIDIPLYLEQNNLPSNPPLLNPASNPVDLPLLLRAVEHFHLQPRPGDVLLVRTGFEDVYREDSEKAQVDRHRESAIQGRWYGVEGKEEVVKWIWETGFVAVGSDNPTFESWPVWENAVWMHPTLLSGMGIPIGEILRLNEVASECHRQNRWSFYFSSVPLQIENGIASPPNAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JNX9</accession>
    <name>A0A1E3JNX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033089.1">
        <property type="nucleotide sequence ID" value="XM_019174710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JNX9"/>
    <dbReference type="GeneID" id="30191777"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31318" checksum="6B2276B139237523" modified="2017-01-18" version="1">MLLYLVRHGQTALNQTNTIQGQSLDPHLSSKGLAQAHTLASHLTLVPFTSAYTSPLHRALETAEVILDAQGKGRDDKRIKVKIDDRLITRGMGIAEGREWEEVEHELGSGEFGVEGDEAVRRRLSGWLGSLLKLHTPVASSAATPAGARTPGTPSFGFTRAKNGEAVNPFELMKALPRPGVSRTPTTAAGGGLGSGVVLCVTHQECLTALITLLMPSSSPPASPHSSTGKVNIKRPLIDVQIPESVKLRENVGNTGVAILRVWWEEGEDAELQPRGRLEAWGMDEHLEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR19</accession>
    <name>A0A1E3JR19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033372.1">
        <property type="nucleotide sequence ID" value="XM_019174320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR19"/>
    <dbReference type="GeneID" id="30191379"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27454" checksum="70ADE3F6B3CC7AA0" modified="2017-01-18" version="1">MSQRMFMIERIAYQPEPHRADQFKVLGSTGNVYTVTIGSTPDCDCPDCEKGNSPCKHIIFVFLKVLKVSIGSPIWYQKGITPAELNSVYAGAPAEPSASVSVNSRVRDTYFKATGKEPPAEPAQGGSGGKRIAAIGEDCPVCYDEMTQKDEDMKKLVYDESLGGCGRPLHDQCFRMWAATAKKQHKDVTCVWCRSPWAGSAGASQGKGKGASKTGVSYSSMGYMNMAHAAGISPRRDTSTYYHGRGHRYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRR9</accession>
    <name>A0A1E3JRR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033620.1">
        <property type="nucleotide sequence ID" value="XM_019174568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRR9"/>
    <dbReference type="GeneID" id="30191630"/>
    <dbReference type="OrthoDB" id="2560010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130521" evidence="1">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="16646" checksum="07DC98552146F5F2" modified="2017-01-18" version="1">MLVNILTLLSLLGAAAALPTSVGTRQDATDLPPTAKVIKPANSTMEQFKAEYAPSSIHPRARLLTKKHSFEDFCPRYYAPHDHGQTDQPIFISQSFEADSLSDDAAEKKRDIDPDDIATVSCIYLYYSTTPYQNIGVDVAIALGGDGLVTIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRY8</accession>
    <name>A0A1E3JRY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033646.1">
        <property type="nucleotide sequence ID" value="XM_019174594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRY8"/>
    <dbReference type="GeneID" id="30191657"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="59519" checksum="75BA1A3E19868596" modified="2017-01-18" version="1">MLRSAIPSSARALARSRAPRAAANVARPTAASFARHLNTKPVSSPAASSLTDKNHSGTHSSSRITPSNKSKVWSDAKSAIVDIKNGDTVLSAGFGLCGTAETIIKAIRESDLQDLTVVSNNAGNAGTFGLSPLITSKQIKKMILSYLGTNKGLQAAYLAGEIEVELCPQGTIAERLRAAGAGMPGFYTRTGTGTFVETGGIPQKFSPDGKEVVIPGVKKETREFDGKKFLFEPAIHGDAAIFRAWKVDKAGNCVFRYTTRTFGPLVARAAKLSIVEAENIVEIGELDPMEIDLPGIYVDRIVPATENKEIEIVTTREDSDNVSPSSGEEVEKKEKPKSQLQREKIAQRASKELFDGAYVNLGVGIPVLAANYCPDGMKVWVQSENGILGMGPYPAKNEVDADIINAGKETVTLVDGASVFDSSESFGMIRGGHVDVSILGAMEVSANGDLANYMIPGSLVKGMGGAMDLVSNPDETKIVVVTVHTDKHGRPKIVQDCKLPLTGAGVVGRIITDLAVFDVDRTGEHGGGLELIEIAEGHTLEEIKEKTGATFRVKEPLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS32</accession>
    <name>A0A1E3JS32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033684.1">
        <property type="nucleotide sequence ID" value="XM_019174632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS32"/>
    <dbReference type="GeneID" id="30191697"/>
    <dbReference type="OrthoDB" id="2571718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="40459" checksum="4B01A26E5BE90C45" modified="2017-01-18" version="1">MPTITPSQFASLHPVHHLILDQLIASAPHSALRLCSSVHKRALPIIYADIYSSPAVFKGLQSNEGYERTVEALKSTKTIRVRDFTSIDTLYSLSGPEREQPPAPSPSSPGNNTHPYPRRYVNLFPSLERLELGFPALQTTYHEYLEVLESSNPAAEEDETRPLNFLARRLSKQLPNGVKEIAFHLDNDRVDYWYEIDQHLLFQRPREAVILLKGTVKTADEVAQSNATFGRLGEELPTEWPNAERLTVFVDTDEPLDRSDSEQVQCYVVPMSKALAKYAQGIAWRINLGQEKRMLGDEDDVEMRLVDHVQIYMPLVGRVLEQMTEDGRNQVDGLVRDGRLVVGEYEESMVDGLDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW53</accession>
    <name>A0A1E3JW53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033730.1">
        <property type="nucleotide sequence ID" value="XM_019173923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW53"/>
    <dbReference type="GeneID" id="30190975"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="103" mass="11283" checksum="6746AD3FB221CD1E" modified="2017-01-18" version="1">MSSSGPPADAKKAQQAALQDIEAARFKKRTIDSNLAKENLYLFEGSYLDESAASGGNIIKGFDNYLKPNTAHTHKKKLEVTEADRLFSNSSATFQQVTSIRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW86</accession>
    <name>A0A1E3JW86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033769.1">
        <property type="nucleotide sequence ID" value="XM_019173962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW86"/>
    <dbReference type="GeneID" id="30191014"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="148"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="266" mass="29782" checksum="89743E38A3F449FF" modified="2017-01-18" version="1">MSQIQEEQRGGGPPLTSTTHLNPPQASTAQGDAQLQAEHQRHHPLRHHHSILSETEEELTEEELIEYEKGVLTWEKAKNWRFWLRKEWAWYYVAFVLIVAVVALMAFFHHSIINWLSPFVKRLRELKGGFAIPAAILFVLSFPPLFGNEIVIVLVGLVWGLGKGFAIVVVGLGLGELCVFLMFKHWCHTRAERMTRKSLNYACLAQAIQDGGLLMAWIVRLSVIPTQAVFAVCGLPTWAFILALIGALPKQLISVYVGGMSPPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWB1</accession>
    <name>A0A1E3JWB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033738.1">
        <property type="nucleotide sequence ID" value="XM_019173931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWB1"/>
    <dbReference type="GeneID" id="30190983"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="175"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="545" mass="58455" checksum="37DA3272E1C5ECAC" modified="2017-01-18" version="1">MSDSAPPPPKRKNYTSWTYTTTTPDPSQQTWKEKIKSKSSVWGKSALDKGVAISDNLGGKVNNFAEQRLGTEAFWPVTGDFIKEMDKCARILRAFTVDGLVTESKEEEDESGRKKKKKVIRKIPPAVIAKAKGLAIFTSMRSGIAPFGGAGGAGLVVAKLPDGSWSPPASITPNNLSTGFLIGVDVYDCVLVINTAKALQSFRTHKATIGAELAVAAGPYGAGAAVEAGLEKAPLFSYVRSRGMYAGVELVAQVFVERFEENEAMYHWPGVKAGDILSGKVKMPIEASGLMKALADSESGRAQKEKGDALDIIIPEGAFQLELNDGEVLKLPPTPDQTDGHEYESDPETEKIRRASRPGSHNPSMSDLGNIHAPVPTRPPPLPSRHPNRPSLTHQPSSTSHYSASPPPSAPPLPPRSNVNSAQPSRATSPHIPAAASPAPEDLPTYAEVEVTPEGGVNAKPYPKDEMDAQKLGLAEDAVGEGGEPMSPAEQKEWEQFMAEHEENQRATEVEKAASVTGVAKEADVLARRLDVQHLDKENESESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWH0</accession>
    <name>A0A1E3JWH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033864.1">
        <property type="nucleotide sequence ID" value="XM_019174057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWH0"/>
    <dbReference type="GeneID" id="30191111"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="61218" checksum="1C1652E9A999B8BC" modified="2017-01-18" version="1">MSPTAISDNFQQVDFQDLKSKVVEGHVELEETPKPSVADDFMYDFKYNHSLPTTDALGVSIPEDADPQAAAEELLAKLSQALGKGDAQAFTGSFLDYGVWRDKLAFSWDYRTFNWAENISQAAADLLPTNRCGKFEILKPALQKPYPDLGFLQFILAFDTPLTRASGLLIAEGWKIWTLHTVAASLLQFPEVDPSDGHMTGSVSWENQRAADDDQIKPDVLVAGGGQNGLAIAARLKALGVSNLIIERNAEIGEIWRKRYEYLADHLPYFPFPKQWPTYTSAQKLGIFMQWYASALELPVWTKSTITKAEQDVDGKWTVEINKDGETRVLHPKHVVSNGLYCSLNSSYMSSGHGYFTVRCSNDARRSWYGQVEGNVRHSTANDSSRDWVGKKVLVVGTSSSGFHTAYDCAGVDIVVTILQRSPTYVMSLTHSVPRGIGNYEPKKGLPLPDFEEQDRLFHSTPLGPGEPLARRNCATLEKLDKELLDGLHAKGLKTYAGQRGTGQVTLGSTRNGGFYFEAGACEQIIKGKIKVEQGFVESFTGACDCFWRCGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWL4</accession>
    <name>A0A1E3JWL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033845.1">
        <property type="nucleotide sequence ID" value="XM_019174038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWL4"/>
    <dbReference type="GeneID" id="30191092"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="258" mass="27531" checksum="DB5918C7FAFCEED5" modified="2017-01-18" version="1">MDHSSSPLNLSSLNINDVNEGAGQEVVLPRPASAHSSKSEDWDPGECMLPSNSAHTAYGPPLHLQHDKTGKTSSLEGLLSEDRTVMGSWGLLGPACFPGKVSTRPMRSRRPGGPTIQQKVFRSAWDTTPINGKMLDDDAKVVGDHVTEQARVTVRMNGLSPMVPDGRAYITTLGLDSHLASLPVSDSSALTNMLSRPSIYESYDPLLWRCPETEHKLWLNKSGGESGASCISLGSAGASAVSGVRAVRGVAEEVEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWZ5</accession>
    <name>A0A1E3JWZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034024.1">
        <property type="nucleotide sequence ID" value="XM_019174217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWZ5"/>
    <dbReference type="GeneID" id="30191275"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="204" mass="21924" checksum="3408F405F2F7F358" modified="2017-01-18" version="1">MPPSQSTPLLRQPSYTPSNPAPLPWPLLLPILLLRMADAATYMLIFPFITSYIISLNPPPTLIGFYAGLAEGCLMGVEAVCAVGWGWAGDRWGRKKCLVWGVAVTGTFGAVAGFGKSIGWVIFWRAMYGFTPTGVLTKTVVAEIAHPTNRARIFAIYSPAFSVGIIIGSLLGGELAGPARRVGQDWAWLQEYPYALPGVVNGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX12</accession>
    <name>A0A1E3JX12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034025.1">
        <property type="nucleotide sequence ID" value="XM_019174218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX12"/>
    <dbReference type="GeneID" id="30191276"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="25111" checksum="FAEA947131383B4B" modified="2017-01-18" version="1">MLLTTGTMPLEALIIPIAQYAATLSGRGGWGRAPTWVMLVIQVGMKNFHCMAWPQNDHLIYSVLDGYPRLVGSASAVVLIAGATGRAVGPVISGYVNCHKLSQDSTVLTLNNPLLPPVPTHPSLGALKLPSFRSLHRHHALNYTFPRISPRNIIGINPYRHRLPPSANMDQPPLMTGFIPEGLHKVDDKEETLGEFVGGRAEEGPEGEEDGRAELGQGKDVGYGATEIREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX14</accession>
    <name>A0A1E3JX14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034016.1">
        <property type="nucleotide sequence ID" value="XM_019174209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX14"/>
    <dbReference type="GeneID" id="30191267"/>
    <dbReference type="OrthoDB" id="10284093at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="416" mass="47446" checksum="A5CEA3488C89A686" modified="2017-01-18" version="1">MPCACIDQRLSHTPLNHGGVLPLPLEIREIILSHVLAHLCPAHLFSHSLISREIYSANMPLAYEKYPVVLTDKNYRQFFYGLLRPTALTDLEVGPPSFILSDASASLCFTSPDIPHKTKLLARVKSLRIESPQAFYHVTLMVREWPLIRAWLYGEGFKFDVDWRQVMFASLCVFDISYQVVAAVSASKGWMESLRAQKFGRWSKTETGEAHVVCLDIPKGFQSGSEIHKSDMSWVISFAYSLMDTLDYLELRNVDMSKWRWSESAFRGELPLEIKVIMAPECYLKEARPVNPVFPAQQICSIWEGCRAFYKAHEAVSRMYEEGALDTEPRFRTKFVFQNFGAATPNHPTLVSLKESLSIALTGLQREIGRWSLFEPLISIQAPVSRYTEEGAKIWSMEIPGYHGRREGGEDDLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX19</accession>
    <name>A0A1E3JX19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034054.1">
        <property type="nucleotide sequence ID" value="XM_019174247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX19"/>
    <dbReference type="GeneID" id="30191305"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="22883" checksum="B1F19895C8221690" modified="2017-01-18" version="1">MSVTASSLHSLTNDPSTLTLSPGVQPTDLQRQHIAVVLDLFQAKGTKAKLDDNFTKNAVYEDLFASCKTREEVGGQLLHLPTVLSSATTQSYTVSQITPNTSTTDGTGRTLSTDLISIPIKHTFEFKVPLLPSKLKSITMDSKLEIYSSKDEEGGKIVRLQDRPKENIPDFALLNWMRKFNAETVPKVVPLPKNDKEDAEKALKQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX88</accession>
    <name>A0A1E3JX88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034110.1">
        <property type="nucleotide sequence ID" value="XM_019174303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX88"/>
    <dbReference type="GeneID" id="30191361"/>
    <dbReference type="OrthoDB" id="2593594at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="867"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="958" mass="94362" checksum="5A2E8C62334AE994" modified="2017-01-18" version="1">MSAPLAHAFADLAAPTAPTASTSGFANADPPPPGGLASSPHVPKPGTSIDPATGKPHTAGLTRTELDAKKAAAIQAAAPSAPAEPPVSNSDGLTTSAGLGGEWGPGLASAPGVPKPGKSINPETGKPHTAGITRAELEARKAAKAAELSPSEADHIKSKGADLLDPAPQTEQIRRGSLTAPTTERRPSDVSGREQAARQLLAAQINEAETASPGTSTPGQEMPGAWGDNKPIPLPGTSANAPTTLYEDVAEGLGKVGQAAFAVIPSPIKEAFHQEAMGAPRRVRASATSIIDQARVQATKLSGNLQGTLESTQRRASANFGPDGTIRKQVLNFVDEAFQSTKELSNAEFGFVASGPGGPGGRITSPSRPTSEYLGSVPGEKSDGTGALPGSITETGVAILPEEKNLKNERSTNQNVRPGEASPGNSFYAPVVASSPAGPSDTSTSGPSTSSTLGPKPSGSHTVVNAPTASTSRDAPSIPTSFASNPTDPASHAVPAPTEGAATASKKGETVAPATSASEPSGAGSLGSSEPLESSRAVGHSGLAPALAPALPATILGAGAAHGATALPSSSSEPQHEHTAVSSPALTAPGSSSTLSEDASPISTTTSSIPAGVPQTLHGNDRTTSTSSVTAIAHGREGLPFERSAKAGGIAESPLREGVVAGEEPFSSAGVSNAKSLTPGKEEHGVGHPSSHGIAGAQRDVGKYPAAEHGEAASSSGAAGKSSGTGEKAALGAGAGALTGAAVGAGSGRGEGAGLARSEKEQLGDRARADVPGESNLAGASTSQTTPSSSSAAAAAPTSQSNSHTTGHTTDQVVGIAPGQTRVRTEEEKLADRGKADVPGFTEEEEKANIPGNGRDVLGSKHLSEKPAAAGAVGAGSAVSPASPSTKTAPTTATTSQTTPVKSPTSATTPSSATPTSSSHTRTDSAGSGSGAVSASGTPSKKEKGGLLKKIKSGLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYD5</accession>
    <name>A0A1E3JYD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">L198_01906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033872.1">
        <property type="nucleotide sequence ID" value="XM_019174065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYD5"/>
    <dbReference type="GeneID" id="30191119"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="434" mass="47852" checksum="35A58FC8DD9A684F" modified="2017-01-18" version="1">MLSYLHATGMQDSFEALKRETENDDFVMDDPKARWVGLLEKKWTSVIRLQKKIMDLESRNAALLAELASPTRASAASSSSSQPFIPRAPARQTLTSHRAPITRVAFHPKWTVLASASEDASVKMWDWEGGEMERTVKGHTKAVMDVDFEPKGNLMVTCSSDLTIKLWDTSNEYTNVKTLHGHDHSVSSVRFMPDGEKLISASRDKTIRVWEVASGYCTKTFSGHAEWVREVVASEDGLWLVSASNDQTSRIWDFSTGETKMELRGHEHVVECAVFAPVNSYPAIRELAGLKANTRAKAPGAFVATGSRDKTIKLWDALSGQLLRTFVGHDNWIRALVFHPTGKYLLSASDDKTIKVWDIATGRCAKTIDAHGHFVTCMTWGRATVGGSASGEGEGEKKEAVNGVEGKKEEPRRINVLATGSVDQTVKVSTWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ01</accession>
    <name>A0A1E3JZ01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034121.1">
        <property type="nucleotide sequence ID" value="XM_019173416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ01"/>
    <dbReference type="GeneID" id="30190462"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="166" mass="19168" checksum="3EFDE61745068F74" modified="2017-01-18" version="1">MADRNRWQAAAPPPHPDLLAFVQNLYDQGMANWRAVNTRLEQDGSPWRFRSEYTFRRWCDEHGADRAAARRFGQRNIPQRPIGLFNGSNERWSGDGYDKLSDWGFCFYGWQDVFSGQIISMCLLPSNVHPQNTHWVFLQAVLTASLARSRLIPAPKPISYRGRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZB1</accession>
    <name>A0A1E3JZB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034259.1">
        <property type="nucleotide sequence ID" value="XM_019173554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZB1"/>
    <dbReference type="GeneID" id="30190604"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="265"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO06159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="809" mass="87842" checksum="EC7708E80D20FC44" modified="2017-01-18" version="1">MSNGGNRNRDNQNNQNKRDSFGQGLSKWGIGQDTKSGGGFGAGSRRDDKPPRREGGGKSQADVFGAPLQSRGRDARKVSEEQPQSGGQDEGSSYGGGAMEEDDNDRPRARKNHGRERKGRGESHSLLDRLRSDGEDASLPTTKHHRRNRQPEQPQPEQPRKPKAPKPKVVPVRQEKEVYIPRTVSTANLAKIFGVKLFPLQAKMLQLEMTEDERRPDYLLSAEQACNIAIDYGYNPIVDDEASFDIYPEQVDLPTDPVDGPLQPLRPPVVTIMGHVDHGKTTLLDSLRHTSVAASEAGGITQHIGAFSVPLSSLLPSADPNASAATITFLDTPGHAAFTAMRARGASVTDLVVLVVAADDGVMPQTREVLDLAKNAGDTLGLVVAINKCDKPGVDFNKIKSALGAEGIFLEEDGGDVPSVKVSGLKKTGLDDLVETLSTLAEIRDMRARRDGKAEGYVLESRVDKGRGNVATVLVTKGTLRTGSSIVAGTTWCRVRQMQDDKGKPIREAPPGTPVSVTGWKELPSAGDELLEAVKGEDEAKKAVGNRKRDIERKKLMKDAEQINAKRREERLRVEAETAAAEAAENGEVVETVREVKDDFKTLRLIIKADVSGTVEAVVGSLEHIGNKEAGVRIIQTGVGEVNENDIALAETSDAMIIGFNVSAPRAIQTLAKNTNVPLQLESVIYRLIEKVRHDVAALLPPTIEYSVKGEASVLQLFQINVKRKEFMTIAGCRVNNGVLDKSQGVRVLRGPDRKVVFEGSMGTLKHLKKDVQDVRKGMECGIALEGFTDIKEGDEIVTFVKVEVLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG7</accession>
    <name>A0A1E3JZG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034388.1">
        <property type="nucleotide sequence ID" value="XM_019173683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG7"/>
    <dbReference type="GeneID" id="30190733"/>
    <dbReference type="OrthoDB" id="2576434at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116306" checksum="E0E7029280B4EC7E" modified="2017-01-18" version="1">MQQPPFLWGAPPPIMNYPLFMPQQQQYPPARYNQPQSPSSDPQVSDSPQRIQIPTNEAKVALSLQGILKSFLDDTWHPDPMAIGIILLALNLIKGLVPDGMMKRLKTSWDLFWPPWQDRSAARGEPAKGKSIPASAEDERKRPSSSDRDTRPPAAPDKAKDAKTTSQSAEPAKETSPLASTEKVAPADTRKESPSEKPKEKSRERPEGSNKEEVKKERSEGSTRERSKERPEGSTEERPEVSTKERPEGSTKERPEQESKEKSKAPSGSTDPTASNKSGDKPKNEVKKASAEPAKKPEDGSIAKQIKDKERETSKDDKEMSQEKPKDKSRSSPESRTPDKKGSESESEKAQKLKEDKALDPVKEVDKGKTRMEGERPHDKTPSKADKPPSDDTPQSPSSSASDTNDALMSGDYRPLKSALKKSKKKPKQTNNIHHNFFMTMRGFRPALIPFPHGFHPKPHYPRNTLWWNNVPKNADHIMAAPKVAKEPDKGDTDDGKEEASKGTPKEPQKEKKDEKKDEKPKPASSKPSSDAKDDGKSKEKELARAKAEAEAKAKAKKEAELKAAKSGSSSSSSAAVSKPSASASAAATAKPKSIPLNPELEKATYITQGLLCVLLYYLHQQLAFLLVAFFAWQYIDKQYTSLRPTEPPKTAVTSSSSSKPPPNSSTKPFSASSTDIDPAMKAKLDEARKSREAKERPVPKEDPASSSKRSDSSKAQEDLEKLEILIKKLKSRDDATDDTKERIKSAIMQRDALVARIQKENERPRGDAEKETKARPEEPSGHSTKGEESAETQLLEKLKAAEMYAKKYQAVESPTDEHRERLRKAEELRKELKAKLAELRKSGASGKTVRAQEAKAGADSSYTDASKGKNKVGSEEEGRDSKGKIKIQDPASSSPDKKDLETSLKEMDLYVRKYRAIDNPDADQKDNLTRAEAKRNSIRKQLLRVFERSTKDPSSVRAVSGDTGKGDTAHHDGPGKKLRQMRDEIKQIEAYIIKHRKLDNLTEEQKTKVASAEKKRKAMKAEASLLEKQLVNIGSSGLTADEKAVIPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZK9</accession>
    <name>A0A1E3JZK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine-threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034351.1">
        <property type="nucleotide sequence ID" value="XM_019173646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZK9"/>
    <dbReference type="GeneID" id="30190696"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130692" evidence="1">
        <location>
            <begin position="27"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="39997" checksum="162DA3F84E89334C" modified="2017-01-18" version="1">MPSRQVLILAVITPILLYLLLHRSSPQELPARAAFRQRLVAVGDLHGDIDNAKKVLRMAKVIDESSNWAAGTDILVQTGDIVDRGAHADQIYRLMQSLRGQAEGSGGRVVSILGNHEVMNAIGDWRYVTRDDIKNFGGSPARQQALSNEGWLGQEWLANYSVTALVPLSPHPSSPSLSFTHGSLRPSFPHLQPYPSAINALGHSLLSRALTPPLAPPYPPNPYSGLPKGHSQAEAELYAEGGPLWWRGLADREEAQVCEWAKELKEKTGVKRFIGGHTPNFEKIVARCDAGVIIIDTGISSAYGGVLSALEVVYTLTPIDEHSQDPLLLSTAVLKGRFLEKEEIHAVYQHGKKRLVVEEREVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K030</accession>
    <name>A0A1E3K030_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034481.1">
        <property type="nucleotide sequence ID" value="XM_019173776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K030"/>
    <dbReference type="GeneID" id="30190826"/>
    <dbReference type="OrthoDB" id="10008801at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="13799" checksum="A6E1C9E3E4544046" modified="2017-01-18" version="1">MCTAFLRTLPRTIPRAARNIHSTPRLLASEIPTSPFEDPIFKAFADRVKQHQGAVDAMKSVMNVMQAKGFDKNKKPTIMQMMQMASDTELKAAASTLMTELQKAGVGMDEAREIFSRAQAGTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0G0</accession>
    <name>A0A1E3K0G0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034611.1">
        <property type="nucleotide sequence ID" value="XM_019173906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0G0"/>
    <dbReference type="GeneID" id="30190957"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="88" mass="10456" checksum="4357C9FE6360BEE8" modified="2017-01-18" version="1">MLNSYHRGIDEGDREDMEIGMREDRAEDQLREHNSDNVRAEGGLQSAGDMKRRRDLYTELLWDRFQSRPRRGRPRGSRGVQEGRRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K206</accession>
    <name>A0A1E3K206_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase kappa</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_01709</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034577.1">
        <property type="nucleotide sequence ID" value="XM_019173872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K206"/>
    <dbReference type="GeneID" id="30190922"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000014">
        <property type="entry name" value="Related to DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="17">
        <location>
            <begin position="130"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="18">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="477"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO06477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="638" mass="71995" checksum="B9B81B45DF45093F" modified="2017-01-18" version="1">MSRPHSLNKGKGKDKEEDEKRKWEEMTVEERAEAEAKQRSFERSLAGPSVGKAGLMRDQTEINRIIAEASKGSKYYKNQVRKDEELNEKITWYRAKRDELMSMAKEEQIEAEADRILMDVEALRDLSQTIIHVDMDAFYASVEVQRDPTLKGKPFGVGRGVLTTASYEARKFGCRSGMAGFIAKKLCPQIILTEMHFDLYIAASKSVREVLVQYDENLMMASLDEGYLNITPYMSTHSMTAAEVVTQLRAQVEEKTNLTISAGIAPNKMLAKICSDKNKPNGQFELSFERAEIVKFMRDLPVRKIPGFGRVTERCLEGLGVETCGQIYEKRVELLLLDHWFGFHGLCKAYLGISDNTVAPGKREERKSVGVERTFRDKTNDDDILACLADIADELEKDLERLQYAGKTVTVKFKLHTYENKTRAKSVTRFLTTAEEILPIAQELLKRELPLRIRLLGIRLSTLKDLTVEEKGIKGFFKPPAENTAEESSKRRGRMSEMAKMDEDDGEIYNESDDDDDPIFVESHPSSHILLGKRKSPTPSTDVPSPSPGPACPICGQHLPGGTSNQELNDHVDWCLNKDAIREASRVSPAVTKRLKADQKRPVVIRGESSSPVKPKEQMKEERVAERGTISAWLKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K248</accession>
    <name>A0A1E3K248_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034687.1">
        <property type="nucleotide sequence ID" value="XM_019172961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K248"/>
    <dbReference type="GeneID" id="30190002"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20127" checksum="94E447DC07E1A342" modified="2017-01-18" version="1">MLFTNKSSDKPKPSRCAPDRDSTSTLESLRVELHTDTAKYVEDSEALANAIALNDVFANPLVVAAAFSACMGGLLFGFDQGILSIVLTMPQFLSQFPDVDKDASFSAAFNKGIMTALLELGALIGAFQAGFFIIGSIIQTTSFSFAQLVVGRFIGGLGVGLLSAVAPVYISEGESLTQLISRAVGRHVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2G4</accession>
    <name>A0A1E3K2G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034502.1">
        <property type="nucleotide sequence ID" value="XM_019173797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2G4"/>
    <dbReference type="GeneID" id="30190847"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="50515" checksum="2B2F1C72AE5369BF" modified="2017-01-18" version="1">MPPATDKTKQAKRPIKSLLDFGLQFFFDRKYFWHFTSLLFLGEILLGLLVIWKIPYTKIDWPAYMQQVGMFLDGEQDYSRIEGETGPLVYPALHLYIYTAFSKIMPSIDDVRPAQYIFLGIYLLTFLSVANIYYLAGRPSANGKHYVQALLVPLTLSKRAHSIFMLRLFNDPIAMLILYWSIIAFQIGGKKGWRVGCAVSDLCCSLALGVKMNILLFVPGLLVLLFQYRGIYGLVEGVSIIALVQVALPAPFFLSSTNHALSYLSSAFDFSRQFLYEWTVNWRFINEELFLSRERAVLLLFGQVIVLLTFAAFKWSPIPGGAIRVVNNGLLLPSQPAGEPSLLPAYHIPLVLFTSNLIGMIFARSLHYQFYSWYFHQLPFLLFSGGAWNSAAIGSIIWALIQWPWEVTPATAFTSLQLLGSHLVLLSGIFFCNPISKEVVPSNIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3C0</accession>
    <name>A0A1E3K3C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035003.1">
        <property type="nucleotide sequence ID" value="XM_019173277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3C0"/>
    <dbReference type="GeneID" id="30190318"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29385" checksum="9FD45D972185D50B" modified="2017-01-18" version="1">MSPAANIKPFLPSSRPSGPVFIALNVLRALSMIALILVFASNTATMVSDIKAIKNPATDDDDCDYIEYSSVPDQIGGAFWSILNRIFILFECILLVMSEIGWPRRLFEYYIPSLGPAYGLGCLGVFQALIGAQVLSHYCDLFPQVSSWILFIVGCLNILAGIFLREKAKEKRLIFSWENVSSLTPQTRMAATAWDMVSEKRKPSAKDPETNLSRHNTTASDTPLVPDRTTPGAKFGGFGFGKQGEKAAAERGWKISRPTDALPRYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3D1</accession>
    <name>A0A1E3K3D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">IKS protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035077.1">
        <property type="nucleotide sequence ID" value="XM_019173351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3D1"/>
    <dbReference type="GeneID" id="30190394"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="146"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="638" mass="71700" checksum="E00A930A2F043288" modified="2017-01-18" version="1">MSLIPEHAWEAIGHTEYQLILYHPASHALQVRNQPHHDHFLSDNITGSTISAGENLEAEDEQVTPILLCPSCARPLPTGAGNVPEGLAGGSRHPAPTNYFRVLEQVHGSTGAFADETTPPPFQNAYDDDPDTSQDLPSRGYYARFFHEEKRLGMGAAGSVFLATHHIDGDVLGQYAVKKIAIGRSKSYLHKMLREVRLLGALRHPNIIAYHHAWIDTTRFSKQAASPYHVYGPDVPALYVLMMYASAGNLDSYLSTRSYSHLPTNHSEGVADNESFDNLPKEERIKEFKRRRQSLRRPSEGGQASGNWSRRRENRAIMLLGWEEILHLFSDIMDGLSFLHSQCILHLDLKCSNVLLHWEEGQLVPRALLSDFGTSEEMLKGNRERSGHTGTMEYMAPETLVHDAVGHYRPSDSYADIWSCGMIFHKLLFLRLPYGDTEDYDALREEILAYPGFIPSEDVLWSLERRHMPPGVVDLLYRLLSLTPEKRPMAYRVKRLLSDIQEYTSQMGLQDVDSALKSETGMGEVALRRSIVDIPSDVNVQPFIPPRTILTRIKSRVSRSLRVATRRGYLRPHQPILPLALFSLKMISIQPAIFGANVPAWAAILLLVLALGDLVGEGKYWSWLLVGVHAGVLYALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3G4</accession>
    <name>A0A1E3K3G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035117.1">
        <property type="nucleotide sequence ID" value="XM_019173391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3G4"/>
    <dbReference type="GeneID" id="30190434"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="132"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="432" mass="46141" checksum="7808A361BB005021" modified="2017-01-18" version="1">MSVVTKVHARQVDITTAKGLFRAEVPSGASTGAHEAHELRDGGKDYVGKGVTKAVKNVNEIIAPALIESKLPVTSQKEIDDLLIKLDGTPNKAKLGANAILGVSMAVSEAGAADKAVPLYEYLAELAGVKPPYVLPVPAFNVINGGSHAGNALAFQEFMLLPTGASSFSEALKMGSETYHTLKKVITKKYGIDAANVGDEGGFAPNVSGAEESLDLLTEAIKQAGYTGKVQIGLDVASSEFFKDGKYDLDFKNPNSDASKYLTGEELANLYHSYVEKYDICSIEDPFHEDDFDAWAAYNKTATIQIVGDDLLVTNPQRIKTAIEKKACNALLLKINQIGTISESIQAVQLSQSNGWGVMTSHRSGETESTYIADLAVALRTGEIKTGAPCRSERVAKYNQLLRIEERLEGNSIFAGAKGLSRGTTAPELHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3K7</accession>
    <name>A0A1E3K3K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035132.1">
        <property type="nucleotide sequence ID" value="XM_019173406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190449"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="695"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="896"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1295" mass="141381" checksum="E03764EE965E7C35" modified="2017-01-18" version="1">MQAHRQQHATPPPLPRLNTRSYSSSTASTTHSALLPPPSPLGAPASIGMGQRSVSNASSASGFGLTDEIDRLSYLYSLRTAVLHHHLLSPNPGTPKPSSIRSNSSSRDPPLPSPPLTGTSPNGSRFTSFSFHSAPSYNTAPKLPDTPTTPTTPPPNLRRKSSAWTLGKGHKPEGEGSKLPKEFLLEFWGILGGEEGDQGWKTAVGAFLGMIKKGTKTPSGLNLREIPTILEAFTSNIPPPSPTCAPQHTHQSHLLQLLYNTLPRSSHFSPMSRAQTDKDRELLSRLRSEVQSYMLAPSPNPAGDGASSNLTTPVATTPKKSPVGLGRPSAQSVDAVRRKPSPIWDGDVNEMINTVGQVWGVRRDVMDRDILDIKSHGKSVELLYMNDLKRALTAISSQPPPLTSSQKSRQAYLSQAFTNIYNDFPSLNAPSDPSEYASPARDVPGGGAGFFFIPSRTVEVFGRLASRCAEAGHSARTRDLLERCREVWGISSRREKEKELEGLVGRWGDSIGTSDEIPLSRTIADGLKLISSDLKAGDPLPSVMIQYLHILLSLTTSNLLTIFPSSRPPPPPPPSLLILFNAAPRLFASQEDSRKTLSDAQDELVGAAIGEYIGAVEEYMGGVGGGENKGLVEGLEKVAKWMEKEVRGVKKAWGRGLESALNPAAIILSRQLPLFLAELQALSHPSPSGQASDIFPLYETTGKLLELWEDLVRDKEHDFELDVFFEPFVRGWLKETEGSEVEGWVARSVGMDSWVPEGENKHSQSVIDLFDFIRGSASIILHDLPLSEYKRAIYLIDYSKTVSFAVNQYASTVLALFVHDINPERSLSPSAEPAYQGMLSGKASSWLAKGQQAVKSLEKKKVDGFVVPPAACVKLTDMGAAKTCLEDLTFALEAAHTARIVKSHHLDTPHTERNVNHVFTVTVVRGQGLLGRGLKGGADAFVVVLDKGTGERRIKTKTILGAEDPKWEQAFEITVGAIKFLELQVFDRQLVGKHEPLGTASFKLDPRSFTSTPTRDIVLPLSPRGTIHIRISMEGGEKNDVQYHLDVAGRALDRAEGDMRRGIVEKMGEFIKAQLSVGTIQALMRPLKDKKRGKVPLSDDEIETSLLPLYDYLNDTFSIFSVTLTFDSRIRLMLYIWHRIIETLISLLVPPLSEKPSHAQPLTSPEVDIVFKWLQIIKAFFNASENGVEHGVPLSQLQAGPYRDIVMLGQYLDLPTPSLKERCSAAVRAAGKTGGSAGRIEDGMRGMALDEGQEGERMAEVLLRIARTRPDTGDFLAHEIGLLTKARVEKQAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K452</accession>
    <name>A0A1E3K452_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035133.1">
        <property type="nucleotide sequence ID" value="XM_019173407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K452"/>
    <dbReference type="GeneID" id="30190450"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25919" checksum="4A8D1B2CFA56EF85" modified="2017-01-18" version="1">MPRESEANLPPTNEGYGTQEYWEKRYAAEDDGRTFDWFLSPTYLIPFFTQLTSNIPSAGKDGKDARILMLGCGNSALGEVLYDHGWKNVVNIDYSKTVIDQMRERHSEARPEMTWLEMDILNLQFADDEFDLVVDKGTMDAMLTTKGDPWNPSEKDVKTCTQEVTEAIRVLRKREGSKFAYFTFGQPHFRKRYMQDRPGFTLTYREIGPPEGFAYFFYTLAYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K525</accession>
    <name>A0A1E3K525_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035074.1">
        <property type="nucleotide sequence ID" value="XM_019173348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K525"/>
    <dbReference type="GeneID" id="30190391"/>
    <dbReference type="OrthoDB" id="2596855at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39636" checksum="B2D9A16E9DFBD6C6" modified="2017-01-18" version="1">MPSITQGSNPSRQSSSSSSPSHDSHDSEQTLYDPRTLAHLPTQSQGPPTSEQGSRAILEYPAPAHSPSRLAHSTSRTTTHLPSPTSPQPSQRGPPPALEEREAWSKPPVMPTLRAHARLCAVLLALFIALSGLIAGWTVFMIHQLKTGSSSDSQGSDDDSASNGQQEGNDDDDEGKWSGGVSPVTMVIDGIFIIAIVLFLALLIRQTSLVSSLFRPPPPPHGPNPLSNPSAHSFLPPWLLPRLPSYVETIGGRGAGTGDVEDRYIVGESLPVYGHNRGSKLLLRSESRGGALRQGENTYSPTDSVGSNHSRGEPLSYDVSEAMTPRPGMMGLSDQQRLELARDQERMVEEERRAGVRDIVEKSHYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5G2</accession>
    <name>A0A1E3K5G2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035158.1">
        <property type="nucleotide sequence ID" value="XM_019172216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5G2"/>
    <dbReference type="GeneID" id="30189239"/>
    <dbReference type="OrthoDB" id="2577201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46019" checksum="33A48E24C0193098" modified="2017-01-18" version="1">MSSPSQVAHTTDILHIIFSHIPDNKDLTSLLRTSPLFFGLIAQKLYRSLPISNVLNPFSGVDAGGRGGPYGKTKLLELVLQTVVVERAPLPIDHPVWANWYKLPPLPAVETVIIHPADRNARQEGDQDTTLPNNALIERLCPTATRLHLSTPCFTAGARGVQSMPSLPCVETLVVKANAGEIMKLKYVVGKLNHGLWNHGQKERPPCLNIKAVHILLWGELVYPDAKLQSSDWDKDRVDKLAIMGLSLSTKVKLRDKIFHNLCEIAERLGTRFSIDELWLYNADTVLERLSKWSTSRKVDDMKAEVERAFEGEMKTSAEYLGMPEEAAEAQVFWRTGLEFYEAFGDVSARDETEECQKAMVEREIGEEMKTLAEDLGMPDEAAEAQVFWRTGQEFYEVLGDVSTRDETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5N2</accession>
    <name>A0A1E3K5N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035341.1">
        <property type="nucleotide sequence ID" value="XM_019172399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5N2"/>
    <dbReference type="GeneID" id="30189429"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="416"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="924" mass="99606" checksum="833BB7C98B60D7C2" modified="2017-01-18" version="1">MAVENLPPRDTLPPTRRTSRLRLRESHSLLASLCRSRVLETDTPSPLMDAFQFFARPSMTNDGQDVGEMRLHGLRLNVGDHKSDDAGSIFVSPPTPDRVESPSDEVTLTPPPSNHPVVRSSTPLSMASSIPAFVARSSPLHSPLSSAPSSPGSVSIPLHVFPEVRSPPKKTLAMAADSLTIAAKRGRRSKLFGFTEIPGSNFSSATSSAASSPDNTPLVKPRAVHRATASVPTISTPLPPPATSASAATSPQMVPRRHPSTVAHTPPIHLPPRRRPENGLKLNLDAIPPISDTPAIHTAIPSTRFGSALIRKKSGQVLKSALKQHGGSSGAATPMDEGRAMYESKSCPSTPSALKFVHFDSHLERIKLFVHDQKPLVVSRDGSPLMEDEGDDYPFGDMEEERKVLQISLPNFPTYHDPQSDLYLESIFLNDDRQSLRGVIICKNLSFQKWVAVRFTFDWWQTTSEVTGVFKESVKGGQYDRFTFTIKLGDLIPKIEQKTLFIAARYNVNGREIWDSNGGQNYQVLFTKNRPARQPTKGARDAAPVQPGMGKAVGGKSSQWSVAGGDDRMADLRAKLDRLKDDDDRPPLSPNSSRNFSFNNKKASPRASLAPLEVKAADSNGRGGSLAARYDFGASLNLARRNSNSPLRSPVPLPEMKTGLLSFDAPKRPSSPAATTFYSPKFDQDKLVGDSNVFTSPRSNAKAVPVPGLKVEGPSPEGPSPEPIAPSLTPKTRTPPSVRAAKVVSTQPPLVRTISAPPKFTIGEPEHIEDNSMGSPPSLDSSSTATATPPESPRSPYDNGGSWSPRTSEASESSTSLNSMSSMASYSSLIEHFCWAGDPSLDVTRRNHSTSELDDYFGHPSSGFSTPRAGTPAGGASAATTPSSTSTYYTSYASNTPTREDLDAVENSLEEGFGRRVGQRPMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5S4</accession>
    <name>A0A1E3K5S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035143.1">
        <property type="nucleotide sequence ID" value="XM_019172201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5S4"/>
    <dbReference type="GeneID" id="30189224"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35461" checksum="85DACD5EB4A8559D" modified="2017-01-18" version="1">MAIFSSLAYNWQHFANHVGIPLFFWRRPTWSVRQMSEQSGKVVLITGGNAGTGYATALALYNAGANVTIAYRSLDHAREAVEGIKKNAESKVGTVDVLELLDLADLGSVQRAAEEYKTQPCQTAGLALLERWHHGHGNGPSKATLSNLKLWSSPTIASPPILCLSSCPPAPSRPESTSLASLAHNLAPPGGIDYLSLIRHPDDVPDPDGSPKRGKNEQERWAEYGQSKWGVYRFGEVSCGLAEKYDPKELIAVAVHPGSLSTNLFQPSRSGPVPIPFPEALARNGRYVTPFNHALEPRGDLVGEEGKKKAVELWEWCDEQGKKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K652</accession>
    <name>A0A1E3K652_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035273.1">
        <property type="nucleotide sequence ID" value="XM_019172331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K652"/>
    <dbReference type="GeneID" id="30189361"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="551" mass="61930" checksum="28456328DD87A806" modified="2017-01-18" version="1">MSSQPSRPDTPSTSSTPDITDDFSRLDLHTLREQSSSSASSAIAAGKDKVDEDEELERFRAQWRQELLAKKSEGGVGGETGKSLPKKENREVEDVEVDGKGKGKQVSPKATKAPQLPTFQDEYDEAPTMGPLAHTVAPTINRTHAPKKTLTHRERAIQTYAKAVESEQSGQLNEALIHYRRAFKMDDEVDKLYTKSMAKASADQIAEKAAISEDLMSEIPNSSDIISPSAPAEEPYSFQRHIQLDADYDKSSALPSIATSTAHKSPLSTILGSLPINPWEFAFLPENDKLPIPIANLPAELIDPILAHLDVIWIERFASTCWRARYLTSASMAWRRVCERIYRPPAMVPPGGAVKTQDLVKKHGGEWRTTLIEEERVRMDGCYIAVCHYIRPGAGEEWVTITHLITYHRYLRFYPDGSVISYLTTDHPSDVVPVLKPSLRGKGLHFGRWRLLRSDAPLDPENDPIWVPSEPHEKKPARIFVSGLLEPGIKEAKYEFEMELALRETSRGRWNKLDLLEYRSVNLGTDETLGLGLRNQKPFYFSKVRSYNPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6W1</accession>
    <name>A0A1E3K6W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035512.1">
        <property type="nucleotide sequence ID" value="XM_019172570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6W1"/>
    <dbReference type="GeneID" id="30189602"/>
    <dbReference type="OrthoDB" id="10462137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="619" mass="69796" checksum="387FB154424E6BCD" modified="2017-01-18" version="1">MSNESIDPIDPVRTKRILPPPRYYSQDSSLNDPEYTERSRSRSRSPSPVRASRSGTPDTNESDVESIHRDLSSFNPRLEVEYGGDFTSAISRLKQWLHQKASAQRQRSTAETPPTNPSGPSYTQRGPQSYQSYAEDVPEETDRTFHDDTDSLFDIGGDDEPSAEARGERVGAGGKGSEGYEASRGRGLDESSASTPRSLTFDDFLPKSAFGNHPPPPDPSRSHSSPKPDPYLMSGALPDVRRNRYEDVDDDPLVKIWRRTKPKEDSDHEYRGRSRSRFTDERSKVAEEEPRSRRRSWSRGRSRSRSRSSLGDTTDGTESRQSPPPLTEASRRDRLRDMLGLPRLDIQPPPPPVETPQWDPPAPSTLWERFTETGVETNLYARGEAVARRMIMESQMSQMSQMNDTYPSSMPSSRFGPPSQFGYGMDDYNSWQPQSRPSFVQPPLPTFPQSWKPSGPIFSQFGQPSRPSFSQFGGQPQSRPNVSRYSRPPFRQSFPTPQQQRFSDTWEDDASDTAAETEEDYYDPHMPPQRRPVRFGGTPSQSFGTPTPRPSFGLQSYNRSTGLRSDQEPPFMRQPPPPGTSIPGYGVYTEDNRFIPSAMSGQSQRPMPFGGGSRDFSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Z5</accession>
    <name>A0A1E3K6Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035765.1">
        <property type="nucleotide sequence ID" value="XM_019172823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Z5"/>
    <dbReference type="GeneID" id="30189862"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30272" checksum="150A5B4F7342CF5F" modified="2017-01-18" version="1">MAFAQNLSRLIVPIAIGATVVQSSIYDVPGGYRAVLFDRFSGVKGQATGEGTHFLIPWLQRAILYDVRIKPRNISTTTGSKDMQMVSLTLRVMSRPDLNELPKIYQSLGLDYDERVLPSIGNEVLKATVAQFDASELITNREIVSARIRDDLLNRAKEFNIQLEDVSITHMTFGKEFTSAVEQKQIAQQDAERAKFVVEKAEQERQAAVIRAEGEAEAANTISKALNKAGDAFVQFKKIETSREIANTLSQNKNVSYVPAANGNMLLQVPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K700</accession>
    <name>A0A1E3K700_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035819.1">
        <property type="nucleotide sequence ID" value="XM_019172877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K700"/>
    <dbReference type="GeneID" id="30189916"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="2"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="125"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1232" mass="131999" checksum="84949B4309ACCFC2" modified="2017-01-18" version="1">MPPPKLLIANRGEIALRIIRSAIALSIPTIAIFTQADAASPHVLAADEAYPVGGENGDGSDPKGYLDIGAIVGLVKKSGATMVAPGYGFLSENAAFAEAIEAIGVTFLGPTPYQMTSMGLKHEARAVAKKAGVPIVPGSEGAVASLEDAVQVAGGIGYPVLVKASGGGGGMGMQVCRSEQELVANFESTRAKGAALFKEPTVFLEKFITRARHVEVQIFGNGQGHVVHMGERECSVQRRHQKVIEEAPCVLFSSEMGKGVRKRMCEAAVKLGELMKYRSAGTVEFVLDVDSPTYEFYFLELNARIQVEHAITEVTHPGLDLVALMIRQGLSPSKSLPPSDLVQEDYLPFDGHAIEVRVYCENPKAGFKPCPGQLHEVLWGSVGKRGRIDTWVKTGTTVTPHYDPMIAKVVVHGETRDEAIANMLTALDDSRIIGPTTNLDYCKIIMSTPEFEAGEIHTTFLDSFVYAPPAIEVLSAGLSTTVQDLPGRFVGKGIPRGGAADGLALSVANLLVGNGTGVEGLEMTMMGAKLLFHVDSVVAVTGCQMPLAIDGQKAEMWSSLPIRAGQTLRIGSASSKGLRSYLAVRGGLLNVSTFEGSKSTFTGAALGGYQGRALIPGDLLTITPSSLSSFTPSSWPSVPAYGNTWQIDVCPGPQWDEEYLSEEGMKTLLEGKAGGGGWKVSPASNRSGLRLEGPRVKWARTDGGEGGSHPSNVVDQGYPFAALNMNGDTPVLFGVDAPDMGGFSCVLTVATHDLWKLGQIRPGDSISFNLIPTSFVPKLLTTLESWLSSPSSPSPSASSSTKSSELLKTNVLHRSQKQGKMDTIFRSSGDRFITYEIGPMALDLPNRVLIELWERSIRSLSLPGIISFSTCIRSCIVHFDPTQISQEALLKVMVEEDGKLGGAEGEEIETRVWKFPAVVDDKWCKEAVEYYMKTARKEAVYLPSNADYLAKNNGLGQDAVYDMITKTPWLVLAQGFFVMLPFMIPLDPRLRLVGQKYNPSRTKTPEGAIGLAGVIGAIYPIASAGGYQLLGRTLTPWNAWAKEDEGESKTLLSNFDQIEFYPVKEAEFIKIEQAYKAGSFKPTSSQKVFKVAEYLAFVASHAKEVEEFKKGQKEASEALGKQEEEMFSAFQADSEKTSASATSTSTSSTSDTGAPGGGGLPIVSPLAATVWKILLNPGDVIEDEEQNVVELEAMKTSVFVPAGEEVVGRKVKSVVVKEGEGVNPGDVLVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7B5</accession>
    <name>A0A1E3K7B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035284.1">
        <property type="nucleotide sequence ID" value="XM_019172342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7B5"/>
    <dbReference type="GeneID" id="30189372"/>
    <dbReference type="OrthoDB" id="10294864at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="30187" checksum="239998E1F7BC0D81" modified="2017-01-18" version="1">MVFNSILHKDSSSESKYSLFGKSRSTSCCPTFPPPCPKRLNASVNLALQCCPSPLDIKGIVLGRVFFDLTSRFDCGLSIQVGCGLVESNFTAAKGGPGEVRVCDVVHYRITQRVLASTMLALLGRLPRPRSEREAEDLLCQVRGLMKGVWADIDQAFNNPSSMRAFETIFLPFHDDRAGFQLALNSLRQDILPDEWEPVLRMGAGMLKVQMIVHSCNGERRKTYQRMAGKMICGHLTDKRSPLSEIERGRVEEQLRVNIDCTPSLESPCYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9U3</accession>
    <name>A0A1E3H9U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000075">
        <property type="protein sequence ID" value="ODN73083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027740.1">
        <property type="nucleotide sequence ID" value="XM_019180278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9U3"/>
    <dbReference type="GeneID" id="30197523"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46741" checksum="1031FB640D431E9D" modified="2017-01-18" version="1">MSDSFQNNNFHNSMMPFAHSDFTQHQSPASPGTLSYGQLFEFNPRSPTPAASPYGQPFTLSSGTSNCASSSNPLKRQISSASLEPSTPVATGSRKKAKAGPVKEKPVGKKPKIKASAELDVDAIGSSRSNKRWSNEELQVLLEFLRDKKKESTSEGAFKSEVMTKATREVNDWRKTKDLDPRLKRAISETYSKLCTDFRLLVQLREGKGSSGWGWDHDKNIFDIAPPVKEEYLKSHPKHARPSAVEESTQENLSDIGSEQDEDAEGEEVERSSVLAPDSDDEGEQDSDDGEVIEVVPPAKQKRHSAVATPRKEAPSRASKLSGPEAMQQHGQNLQFGLDRLATSLMNDVDRASRNELSSLLEDVNSSQLFSPDSEDDIYEMLCSQPRVCDFVMALKPKDRRMRFLQNHLNKQRGGLSQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD54</accession>
    <name>A0A1E3HD54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027814.1">
        <property type="nucleotide sequence ID" value="XM_019180213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD54"/>
    <dbReference type="GeneID" id="30197455"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="65" mass="6874" checksum="CEF40C2C459AF81C" modified="2017-01-18" version="1">MSLTPWFSCGLWPFATMGWPNKTAAPTPSSRPVGTFFPSGSPEATKPIFEANSDAAAKLSAQNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJR3</accession>
    <name>A0A1E3HJR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027909.1">
        <property type="nucleotide sequence ID" value="XM_019180099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJR3"/>
    <dbReference type="GeneID" id="30197339"/>
    <dbReference type="OrthoDB" id="10489986at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="214"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="41220" checksum="EF4C6865C46F8856" modified="2017-01-18" version="1">MNTIESLYGDVLGTVEKDLTQAMSFAAAHIAAEDDDEVPAYTENDVKQITAKLARTHVISILKSQLVRDNWIKAFTPPELGISPDQDADIANEATHVYLKRMSDLSRIHMDRTILGSKATVVWDDYGARMIVLTGGLWQPNRSRHDQDHIDHDVADAPPELVLEDTARQSWAAMNNHGTVVLEDANGALFNFDFDWRHDIFLLSFPSESLPSSSSGPKSQYKRIANPSQVLAHLQNQKKAKLAALPEDKRKEAEERKRWAKSEERASGGKDADREKALKNAVKRKEKGKAKSGKEWSERKRELQKSSEIAIKKRNDNLSKRLEDKRNKRADGSADKKKGGSGGKKGGSGGGKGGEWWWRREGEGGETWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP17</accession>
    <name>A0A1E3HP17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028043.1">
        <property type="nucleotide sequence ID" value="XM_019179982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP17"/>
    <dbReference type="GeneID" id="30197220"/>
    <dbReference type="OrthoDB" id="2574883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31854" checksum="47293F4AD0BDA30D" modified="2017-01-18" version="1">MYDMAYEEELRQQTIMAEVLPDAEMWSKWEKTEAPLRQGRGWYPRLDRHFLELLVISEIHALSHPLNSSSSPPGYAERVHRHVSRVRRVACERIGGERLGAYCERVKEAFEAYMMGGWARAQAQAQAQAQQMQMREDEMEDEHYEEAPGEEDDEHRGRKLERVGSVNREPSPTERPPAYQYHTLDSAMIDDEEDQSHLLEIDFKDVQLDEVSEAGSDDDGSSIRATVGTSGSWSKSSQMDVDNASSYTRLPRPDHAQVHAAIPERAQAAVETNVRLAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRT7</accession>
    <name>A0A1E3HRT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028103.1">
        <property type="nucleotide sequence ID" value="XM_019179927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRT7"/>
    <dbReference type="GeneID" id="30197164"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="6567" checksum="4BDE0D321E3B9FB8" modified="2017-01-18" version="1">MGGRQGGKAKPLKAPKKSTKDLDEDDLAFQEKQKREAAELKALAAKAGGKGPMSGGGIKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HTY1</accession>
    <name>A0A1E3HTY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028123.1">
        <property type="nucleotide sequence ID" value="XM_019179887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HTY1"/>
    <dbReference type="GeneID" id="30197117"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129410" evidence="2">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="41940" checksum="35E43B82FFA2F7C5" modified="2017-01-18" version="1">MTLLTLLPLLLALPSTLPSTLAQVTASYPNGPTNPDAPEFYPLGSYVNQTSESRLISLNSVDDFCLWGPPEKGTGVDTEIGTVEPIVVAYCTKPRNGARLIPDGAITGAHFIKTDTYVQVWGFWDGTQVNINQGDEGGELDPHGAENLGNPIGGNATSNVEGRDVFYEEWMSFISYDQFCLRVCTAETNNVTAALQCEHELDVMGCRFVMAIEDFYATNNSFSSCEGEPAAPPGLYPLSNGSTSTFRQRYTGTWSNAEETGMFTVGQTVTPSSVAFYPATSNCVTYPTISNGIDTANYAVTATPSLLVSGSTVAPSSIGTTSQEAPSGISTSSPTTTAAGSGSSAASGAEASDSGSNGSGGGDSGAAASASGSGSSSSASAAGRGRRVEGVVLAGVVGLVGAVIGAATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVG5</accession>
    <name>A0A1E3HVG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028222.1">
        <property type="nucleotide sequence ID" value="XM_019179800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVG5"/>
    <dbReference type="GeneID" id="30197029"/>
    <dbReference type="OrthoDB" id="2597010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="606"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="821" mass="91678" checksum="D5D0B3FC6E252B5E" modified="2017-01-18" version="1">MNQQTPLSLVVNSSDPPLYRFSTIPPACIPTSIDNALERHLRQVDRHVSLDLGGPADQTTDDQEVTSDPSTTPKPSKPSVEAGSSASGTPPSKRPRLQTPSPEENRHASAEQINSSGQRKPGSRHARRFWQILNPDHVFTFRYDQEVVPRLVRGLRTVVDGLTPSSLDESLALHQLVQFLFLLENRHSDFLPEALARFEEGDPSFGFATYEQRDKKGGSDLVRLVGYGGREEESTALAFSGECQAANIYARHLFPLAADHLSTASQQESRHYQYAPPVVSSVLDLAARPDPDADAEGDKIQVTTSTKLGIQRKFRITLRDLFVLFYVLLHSQIKVKVNPLDGKPSVEVSEEQQELLSDALIAILAQLAQEFHMNRCEYINLGVHDFSVTFQLRDRNTAHVSRIVFRDPATAERDILSKDELTNILTGIQDEMKRNAAVRTLLESKPWETVAQHSLFAVLVAGLLLPVGEGTTSMWMDMENEFVSQVQETSATGLTSDTSQPGFTATGGTSAFKMIPYSAVAAKLQSYQSVDTTHHLLMKRLSCFRWEEDPTFRVQVSPPLTTDESVVSTTGDEKSIRQEPEDLNELLRKPDHQTVLSLLSCPDLSVELLQHLGSGRLWDAYYVKLSSGSTPSQIVVAKICNLYTFTLGDAYEYETPSAAAEAITTELDALNALQAVQGEIIPRLYGRWTGWCQLPNGGKARLECVMLEDCGTSFDQSDELEYHLWYDEEVERSLIERLPAGLSSNVQQQIIESYERLHKQGILHVDVNAQHILFHPVDNKPRIIDFDSAISISEAQATNQDYDAEAEMERIRWMVHADEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HXA9</accession>
    <name>A0A1E3HXA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028206.1">
        <property type="nucleotide sequence ID" value="XM_019179839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HXA9"/>
    <dbReference type="GeneID" id="30197069"/>
    <dbReference type="OrthoDB" id="2576551at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="723" mass="75772" checksum="D012D8EFD06CC637" modified="2017-01-18" version="1">MGQANGRMTDSEASLQASSVTSLPPTPMPEHPEFHHAPHSAPILSTNAFSNMPKALHRSLSKSRRVTPPKSKGHDQASPPVPSVPAIGSSGKSLKMLGRLGVDEELKAFEALVLQAEARAGIAQPQARSMKRHSKCTTVPSVFSHHTPAASLSTTALKLTPPHLRPALYRRNSTSSSIHSSSRGSFKSARRAEREWRAKVAAISSGFGPGNSPSKERAKSSPLARGGPVPPRRTNTPGKMAVPRPFGTRSDSSPPPTAATLLTPLSSSIPSPSPNDSLTPFPSAIHDRSVAKSIQGRKSFETLGHYLHVPEGRDRQASVPNSVSVKENDEHAEEEDGEGERERQLSVAASTLLALEGAGRRIAEAREGDVKELYVFQLEKPKSEVEEKDVEEKDVEGSVTQHEPLKRAISPTSSIPSLPTSFSASPSASAATSPNPTISPLPSLSLPAETDSHTAMIDEPQTPLTSTGLSPASPSSPPTPYSPATAYILSAPMESLGWNEAMLSAPVASALASSAPVGKTSFSELGDIRECEELPVTPATAGHPYTFGKQDSPLAPTPPRKDTIPRLWESGTPTQRTFPSRSVPAPTSLGASGAFSESEKGSTAVVYPRKKPAASTSAAPASRALQPRFAQATVPSSTPSSSRPAPSSSSSCRTGLTPAQKVKMEAMGSRHAPPPGGKGMKRVVGGIDLTPGMGVDGKRPGKSGLPRSDLERWLQGTAGACSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9K8</accession>
    <name>A0A1E3I9K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028434.1">
        <property type="nucleotide sequence ID" value="XM_019179577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9K8"/>
    <dbReference type="GeneID" id="30196797"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN85262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="193" mass="22327" checksum="9F530D768E07C514" modified="2017-01-18" version="1">MRQLKHHEKKLLKKVDFLNWKQDASQREIKVMRKYHIQDREDYHKYNKLCGSLRSLIHKLSLLPAQDPFRQQRETEMLNKLYDMGILDVGVKPSEIETKVTVSSIARRRLAVIVARLKMAQTVSDAVKTIEQGHIRVGPAPVTDPAMLVTRGQEDFVTWVDTSARKRTVMKYNDEVSSFLNVGLWLWVGLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IC62</accession>
    <name>A0A1E3IC62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028621.1">
        <property type="nucleotide sequence ID" value="XM_019179373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IC62"/>
    <dbReference type="GeneID" id="30196582"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="263" mass="28812" checksum="7AFB97EEAD64F262" modified="2017-01-18" version="1">MSHSVFLGASTGIGYYALLQYLTDSPTTTATVLLRKPDPFKADPSLKEFLDAGRVQIVKGDATNEDDVKKLFVQDAAYVISTIGGKPHMTLHGAVNDQPTLCTDAALVLLHVLASLHAQGRKLPRVVTVSTMGLGENHKVMPLALRILYAWLLHSPHQDKLGLELLLQRASSVLPTPPQSTFATLPFLSSSSVSSVKENFLPEVIIIRPALFAGEEPAKGREVTKVGEQVTTYTIRRREVSRVIVEDFLGESEWVNRLPMIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICH6</accession>
    <name>A0A1E3ICH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028661.1">
        <property type="nucleotide sequence ID" value="XM_019179305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICH6"/>
    <dbReference type="GeneID" id="30196509"/>
    <dbReference type="OrthoDB" id="2574455at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="680" mass="72975" checksum="B0D1CB6246F52561" modified="2017-01-18" version="1">MPSSFASLFCRNKASHVDPLPAGYSSRNGALGPTFVPLQPPPDVGLDPDTFREISEAKQKIDLALSHMRLVMSGQGRGRSGGNSDELNLVYNCIRDYSEETLNRWLNTYNDYTAALRQLGQAGKYVEHQQRSASGAWPTPARGLNDSTSRRRAMPLVRQETFATLPDVSQPSEVAQTFGQGYDNPQILPPDHPFFQSPSAAAHASDAPPPVPEKPRAARPVSFQPPPVSKPSTSEIPTRPRPSSWQVAQETSGAFLKAVERLSASESLIPQEYAHLLQRATQQEQPDTSQPISPTTTQVASADSSLNANGMSATASRGKRTIPRVRPPSRDAPMGEKSSAFQQITKMISNPDPSAPSTAPASSASSYRDASGSKASDSPSRDTIELAAAPHVNETPSSVKTLKATRAPPTPPSNSTFGQVTPTRTPPKECPAAHPVQHPPPLSPSATANLLTSSASSSFTDGNSDIRPTSLETTFEESLDPLSRPSKSPARFESRPRAKTLDSPAPQINVNVPSPGLTMRPSEAHEPHPTPMQDKAPQYSRPTRLSDAGSAISPHLSATSLKPDSSIHTPLSETEPISPRKHHSDPTESSQRNLQDVLTPPSKSFSTYSTPRAGYTTPDGSPVKKSNASMFPRRAELGERQPLEERRANTEPQESVEVMSGNPQSVEVVDGNDAVGNSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDQ7</accession>
    <name>A0A1E3IDQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028619.1">
        <property type="nucleotide sequence ID" value="XM_019179371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196580"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1401"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1442"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1580" mass="170395" checksum="288B44A9F47DEBD1" modified="2017-01-18" version="1">MNYPHSMDPNNIQGDPGPSSMAQQAQAQYRPSFPQPPPGAAGLGQGQMNMAMLQQMAQAQGVDPQTLLLAMRQHQQQQQQLHQQQQQQQQQQQQQAQGGPPGQYQPGQPHSNPAQLAFQQQQIARILQLQGRSGPGIPGQGGAAGGPNSPVRPAQPPAHQHQHQPPRSMPPPPIPGTPQHHPSFPPPAAEHGSSPSPMTMGGLTAQQQQQFLAQRAAFMNSPQFGAMQPQQQGMLLQQQQAHFMRGVMMQNAQTVQHASAQAQAQAQAQGQSPSQPPGGNGIINMSPGIHRQPTPSQHPTLSSLPQHMAPPRPGSSASTRPASSSSSPHQGSPGMMHTPPPPPPPPGMYHHQHPHHHTPQPVPVQAPSPTHSVHSHHTPQMGASPMMNSGVPFPQPPPPPPAAASSSSSTLLSSQPQQQQGYSNPSFPIPSQSPSGPEQGVSAQGVQPGVGQGGQGQGQGQGGGQGGGGLPPPPQGLSGVGLQYTTQQQQQMASALGFMSKAVQAQQQAPGPEGARPGSSSQTSQPPLSHPHPQPQPHPHPPTLPNLTNLTPPNHPDFPFDARLLAYLPHATNPSWKAQMQQQNPQLAAAVQSAWAVVQRGGLSREMGGRMQAAMGALKVAMMGMQGGQGGQGQGQGVQASPNVLQGQGQGQLKESPNAATQPTVALPSPALKKARLSGVSDKASGARDRDRDRDRTPSMSGSGRGSVPPAGESPAGGPQGGMPPPSFIPSHSGKEKDKEKETTPGEDAPAAPAPAPAAAPAAARKQSGTGIPKEWESHIPRDVPITRIIPIPIPPSAPHFQTALPPLSPEQIDHVRDWIDRDVAYIEGEKKRHPKTLAKMKRWAEENDKATEWWMLRKGEARVMPQNRLRILWPADKDRLRSQKSHRGRKQVKFSQADFKKMAEVEDHLVPVRLDLEEGHHKLKDTFMWNCADTVVTPELFAQSLCDDFGVPHHLFAQRIITAINERVHEYKDQVLPLIQRHTKEDCRGKLDPEGDAESKALIEVFRRARNWEEEEEEIKTDPDDEDIKLIPHDPNDPEALDDYRPWTVEEAMSLIPEDAPEELRILIKLDILIGAQSLTDSFEWDLGSTVTPEEFAGMYVTELGLCLEFATAIAHDVREQIIVHQRSLFIVGHLSNQGVVLDDEIRAAFLPPITNTLRREDVAMASYTPIFNELENAQLANLEALREKEAKRKKRHGRARRGVVMPDREPIKTHRTLLNNIGPNGVALLANVESAPRETATLSRRRGAALAAEANINLLAQDLPIPAPPSPAPPPPVSRGKRHGRVQKVGREESVNGDTPVSAHLQLPVARGGESMDMVNGAVASPAGRRRANHSRIPDSPSEPPTPLSAKPESAPLPPAYGSAPPSSKKRKILVEPLKAVKAEVESAVPSPTLSSRPSSRKRQAKSKSASRNRKRRMAVIDEPSSGPEPSASDSDDSASDSASDSDSSSSTRPRKQKKKAVVAVAENEPTPAPRSSAVPPSVPVRSSPVVSLESDLPDWANKALADTRGRYQKDDFVVIKKPRQDPSLPIEWRVKCNDCPGKIYTLGPGETLNNFEVHLKNKAHMNNRTAREEKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDY5</accession>
    <name>A0A1E3IDY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028834.1">
        <property type="nucleotide sequence ID" value="XM_019179217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDY5"/>
    <dbReference type="GeneID" id="30196416"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="169"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN86842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="606" mass="65912" checksum="CB728F1E2D4475D0" modified="2017-01-18" version="1">MSSSADTTSTIVPPSPTSPTASRKGRRISIQEEDRPANEKFSNIHRSPTQHSGNTPIYHGTNDVGIHRTTTSGSRRGPPDLAFPYLTTNISRGGITEEYRVETREGYIPMDDPERGLQPVRSRASTLHGDQFVLHDKEKGGMGDKKLVTWLENDPENPRNWSNLYRWTITGIVSCAVIQVAMSSAIVTGDFKDQEEYFGVSSEVIALTVSLTVCGFGTGPLLWSPLSELLGRRLLWLCPFLVYIIFNIPCALAPNIGCLLASRFLCGFFGSAPLTLAGGAIADIWGPEERGFAIAIFAAAPYTGPVIGPLIGGFIGKYANWRWIYWVNMIAAGVVWAATLTIPETFAPAILKRRAQKMRQDTQDPSFVTEQELFRKPLNEIVIETLIRPFEMLATEPILLCMSLYISLVYGLLYAFFFAFPVVFGEDYGWDDAKVGLTFIPVFIGVGLALCVTPWLEKKYTAKGDQAEPEDRLPGMLIGGPFVPISLFIFGWTAPPYVAAAGGSWVGPCSAGIPFGFGMVLVYFSANAYLIEAFPDYVASALAAKTVVRSAAGAAMPLFITQMFHGLGNGGAASLLAGVAIIMALIPFGFAKWGKQIRAKSKRAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IER1</accession>
    <name>A0A1E3IER1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028854.1">
        <property type="nucleotide sequence ID" value="XM_019179096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IER1"/>
    <dbReference type="GeneID" id="30196293"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="16310" checksum="1C2A36C6ABF8C939" modified="2017-01-18" version="1">MSVGEYQGSREDGVGLLVYLSVSLLGELVSVYDCDFPIITTDQLPLPATTPNSMRFPLLKAGWGRPQSLHGQAGQHPSANSQSRLAAEEGEDLAGGEEDEGCPLTARKRGRPKTSTANAWKRAAAALQERGDNIQAGGKRRYVCKALQQARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL2</accession>
    <name>A0A1E3IFL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028964.1">
        <property type="nucleotide sequence ID" value="XM_019179046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL2"/>
    <dbReference type="GeneID" id="30196239"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="17890" checksum="5838CD57F14D050E" modified="2017-01-18" version="1">MQGKLKPGVRFVPESEQERAAVTLLRKLNIMSTNIFGSAGSHKDMREELRALLRHSGMPSLFVTLNPADAMNPIVGVFSGRDINLDERLGTGEGVSAEAQARSRAAALDPGACAEGFHFMVEKFVDIFLAYDDPHRGIFGKCLHHYGVVEAQGRGALHMLICIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFP3</accession>
    <name>A0A1E3IFP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028994.1">
        <property type="nucleotide sequence ID" value="XM_019179076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFP3"/>
    <dbReference type="GeneID" id="30196272"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="83" mass="9276" checksum="29CDAC00921E6F46" modified="2017-01-18" version="1">MANLGVPVKLLHESLGHIITVELKTGEMYRGKLMEAEDTLNIALREITVTARDGRVSQLEQVYIRGSMIRFIIVPDLLAQAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFQ9</accession>
    <name>A0A1E3IFQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029000.1">
        <property type="nucleotide sequence ID" value="XM_019179082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFQ9"/>
    <dbReference type="GeneID" id="30196278"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="329" mass="35395" checksum="D3FCD94C7970305A" modified="2017-01-18" version="1">MPLTTELTRLLHIKYPIVQGGMQWVGTPPMAAAVARAGGLGMLTALTQPSPDALRDAIKETRRLIGGEKSGRFGVNITLLPSINPPDYAGYARAAMEEGIDIFETAGNNRQWSSSVPKRFVIHKCVTVKHALSGQKMGVDMLSIDGFECAGHPGEEDIGGVVLLARAAKELSIPYVASGGFADGRGLAAALALGASGINMGTRFMCTAESPIHQNIKEKIVASTERDTIHIFRRNTARVFKNAVSTEVVRLERRPEGAKFEDLRELVAGARGKQVYETGDHDAGIWSAGIAVGLIDDIPTCSDLVKRIDREATEVIQRLHGMTEARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHM4</accession>
    <name>A0A1E3IHM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029168.1">
        <property type="nucleotide sequence ID" value="XM_019178891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHM4"/>
    <dbReference type="GeneID" id="30196074"/>
    <dbReference type="OrthoDB" id="2577521at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="52207" checksum="E85D9A2E076E8DA5" modified="2017-01-18" version="1">MSTSPPKTPPLHSELTTLSPLPTDVISLIYACYLAQDPLASRSQFLNLIVLSKEIYSENAWRLYEAVELNAQNHKAFFDGLWNAGDVHVCQSQSPCPPNLRCEASAKALAREMEVYSHPKRELERPSHIPSDSDIPYPKYEYESYIPFHLHPAIRKVLLIRQCRRLYIDTWGAFAGLRKNNHSVRDVVTAWPRGHVVRNDEAFDYTWISDPLFFSVTHLSFGEKANWSCPSMQYKCFGPALKHLCLSFTDAFYDLDREYEEAAESGNLDEFEEREPRAYITTLLRERLFFALNSEVDEKTSLTLHNAWPDDIEPGLADTMIYELPRSTENGDGDWKRQLAMTTWEMEDYMFELEKRIRDGRWGADVWRPTMKPWNVRFTNMAPIPANTDIISAVLDDYPFGQDEHFDGLFKKWWEEVVSFEGSMKCDCCEIFKKGHPKVGMLVPHKGRHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHM9</accession>
    <name>A0A1E3IHM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029106.1">
        <property type="nucleotide sequence ID" value="XM_019178829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHM9"/>
    <dbReference type="GeneID" id="30195989"/>
    <dbReference type="OrthoDB" id="10545167at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="22095" checksum="A71A384665029ADF" modified="2017-01-18" version="1">MSVLYSTALESFLSSTQTLSSTSPESIPDLATGSTYKSEIEEAKEKIDGIVNGLEEWLKMEDASAKVTAESEQEKTEPASEDASPSDDPPPSEPPPPSEEAPEKEGSDDPPPSGTERAPEATPEPESTPPTTQNPTEVSEVPATGDDSQSETSSISTDDTDPGASTDNTASSSTEATVSDTPAGNDSHPEDSSTADASAAVENSTKEEGKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKT9</accession>
    <name>A0A1E3IKT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029499.1">
        <property type="nucleotide sequence ID" value="XM_019178592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKT9"/>
    <dbReference type="GeneID" id="30195749"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22416" checksum="1024BBB738211A80" modified="2017-01-18" version="1">MASINSKILRSANAPQTAPSEIEQQIAQALIDLEANVPELKTELRQLAFSSAKEVDVKGGKKAVVVFVPVPMVKAFHKVQQRLTRELEKKLSDKYIVFLSQRRVLPKPSRASASAQKQKRPRSRTLTAVHEKILEEIVFPSEIVGKRTRVAQDGSKLIRVYLDSKDQNNLEYKLDTFSSVYRNLAGKDVVFEFPVVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL97</accession>
    <name>A0A1E3IL97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_06753</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029290.1">
        <property type="nucleotide sequence ID" value="XM_019178807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195965"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="509"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="819"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1301"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1495" mass="167833" checksum="017FCA194E52B4C5" modified="2017-01-18" version="1">MSTALERLKEARKKGGSLSQWKPTEETDIFDHVTEDQYKAIVGDRLDQDDFIEDDGTGDYVDDGREDWDGAESQEESEDEDAFDGEDEEYRKARKLKKAKAKAKAAANPDKATKAKPKAKASYSDYARPSNKSSTSYRAAAPSALAEDDFMASLLSGIDAPSTTRKRKSSPEIPSSDGFPEPSSDSSFFSSSRKRYGAESDDETMWDAKRGIMGKKPRVSDVTVTGRRDSHMDVDQENDIQWDDDSMDIHEVKAERADSDDDDIRVKSKPLTTSKVNGVTTKRKVVNASSVKHVLKREPSPVASPAAVKAEKAEVEMEVEPKVIKPRLAAKPKGKSKHWSAIQADLAAKAAEADVDDLEAAKAPVNSTIHSDDVLETDGSLKFFWLDHYEEAGHIHLIGKVLDQKSGKYVSCCVSVLEMERCLYVKPRAKKFADGHQTDLDVSQDDVLDEFDSFRRKSNISETRVRWVRRQYAFEDQTVEREESDWLEVRYPFHQPEIPAGSSGSTFSHIFGTNTTPFELFAVQQKIMGPSWLEIKDLSLAANAATWCKIEFCVESPSTINPFPETDNAAPKDTPPLTAMSISIRTIVNLRENKTEVLAISLRAWDDYNIEDPTPPDQLRSQITTVIRPIEKFPAGFEAFAKNPKEGNSFHTVKNERSLLNLVLTHIQRHDPDVLVGHNFLGTNFETMLYRFRELSVDKWSRIGRFRRGKGIKISKMGSNVRLLSGRLVADLSSDAAKGMISSTTWSLTEMCLTHLKIQREDIDPEDTATYFDHSAVSPDKLITFTRLCEVDAFFQMAIAARVQILPLTKQLTNLAGNSWNLTLNGGRAVRNEFILLHEFNRLGYVCPDKAPFKAKTKASADGDEGNEDLGVMKAGKGKAKYSGGLVFEPKRGLWDKYILVMDFNSLYPSIIQEFNIDFTTVVRGQDGDDEDKIPEVPRSGEAKGVLPKIISTLVNRRKQVKGLMKNKSATPAQILQWDIKQLALKLTANSMYGCLGFVGSRFSSRPLAALTTFKGREILGQTRQTAENDLGLDVVYGDTDSVFVNSNVTTYPEAFKIANDFKKAINDKYRLLEIDLDAVFERILLLNKKKYAAVKIDESGERITEVKGLDMKRREYSQLSKDCSTAVLKEILSGESTEVVVQNVHDYLIQVGEAVRNNEVPLEDFIIFKRLGKNPEEYPEKNALPHVQVALRMKAKGTSAKAHDVIPYIMCLDEDGKSGKTQSGDRAFHPDDLRRQGSELRIDYEYYLDNQILVPVNRLCETIEGTERARMAECLGLDPRRYANTASAEAQEQEFATFDSQMSDEDRYRDVDPLKLTCPGCMEELAFVGLPGKEEAESQIRANGICCDKCNTPIHSASLGLQLENQIRAHIAQYYLGWMVCDGEGCGSRTRTMGVYGKRCLGFAREDCRGTMRLEYTDMKLYHQLLYYRSLFDVDKILAPLQGSKRLEEVRPVTLANKKLLSDLVNVTDKYLSKNGRRYVDLGGLFKFMEKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILZ2</accession>
    <name>A0A1E3ILZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029526.1">
        <property type="nucleotide sequence ID" value="XM_019178370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILZ2"/>
    <dbReference type="GeneID" id="30195516"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="376" mass="40993" checksum="A73270250E30640E" modified="2017-01-18" version="1">MARLAHLPHKHVLELAGPDAHKFLKGLTSKDVEYLAGGYSGFLNASGRVLHPVFIFPRSPNSYLIAHESPPHHPAPLPALLPPFKLRSKVRIKDVSEQWDAWSAWQDTVPEGPSPLRTWKMGSGGAAESRWDWQDGIRTVGLSEQEVGCWDLRAGWNSMGRQILVPKGQSPSLSSSHDIASLDDYKLHRMLLGVPEGQDEIIPGSALPLESSMDIHGGVDFRKGCYLGQELTVRTYHTGATRKRILPVRLFPMDHSGSILDLISSPSPASSLEATFPLDITFHPPTSSASKKPRSAGKILSLHNTVGLALVRLEMAERTWWSSDNLATSASQWAQGETGRLTTQINGKEYGLYVGQGEAYASALANTPSSGLETSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMB7</accession>
    <name>A0A1E3IMB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029659.1">
        <property type="nucleotide sequence ID" value="XM_019178503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMB7"/>
    <dbReference type="GeneID" id="30195656"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129837" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="61"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="39799" checksum="707BC96FE8115B53" modified="2017-01-18" version="1">MLSLPLFALASALITLVPQVAAQTCNATSLCSESAPCCSEYGFCGSDSFCLGGCEPLYSYQTTSCRPDPICVSLETDFTDLSRVNQNASDYTGKATAWDWVINSGTILSTDDGARLILTQDNGGTKISSTRYMIYGTVDFVLETSKWAGVVTAAITMSDVKDEIDWEWPGATTDQVQTNYWYLGVANYSATEGASSSVSSDTASNFHTYSFEWTEDYINWNIDGSTVRTVQKTDTLSSDGSQYKFPSTPSRIQISIWPAGTSDNAQGTIDWAGGMINWDDSDYVSNGYFWNTVKSVRMTCGQDEMSVGTNGTTGWVYGGNGMDGVPTVTFTNETTLLTSSATQSSPIGLKKAGMLSIVVGAMVVLGGANVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INN8</accession>
    <name>A0A1E3INN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029736.1">
        <property type="nucleotide sequence ID" value="XM_019178298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INN8"/>
    <dbReference type="GeneID" id="30195444"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="40285" checksum="CFEA3F292A7CE118" modified="2017-01-18" version="1">MSLPYDATPPPQSPPPAPQDDPMDGPAGLDQALDDYAPPVPSHVQDLMARMSRNKVYLVEESPAILHVDAMKERVRRDPKVKGLMQLLEEQDPSVWLGIEWLNDTSLHVLFETSAEALLALSLLSKTGFDPVEGDDPLMERSAHSFPIHLLPQAPQKPIEERTIPAESSSEDAAVNRRGRGMFAGDGERAIASEISYELAPGVNPLARIAIRIAFQQDADLKGRRDTSKWYATYGRDAGKESLAQPRRVGKGRSETRWESAPDAYESGGHELLQRVGRERKPYDRPEPRGDGRGRGRPTQDDLDRQLDNLRSGGGGSMDVDGGGASAYGQEDEGIVRKGRGFRSGGGGGRGGGRRERPKPGKEDLDKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INU1</accession>
    <name>A0A1E3INU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029730.1">
        <property type="nucleotide sequence ID" value="XM_019178292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INU1"/>
    <dbReference type="GeneID" id="30195438"/>
    <dbReference type="OrthoDB" id="10551975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129921" description="Btz domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49657" checksum="7375B9E609132529" modified="2017-01-18" version="1">MVHPDLFTLVVCLKTMSLLGVWMGRDERGGFVTSKLQGKGIAPQDLGLPSKSSSSSSPSTSSSAPSSRHRRHRDTAEPESSQLSSSRSGKPPSRKPKSSDGGNEASQVGRRGGDEGRSADGSGRSRRGDEGREEPRRRERSSKRGPPAGDDASGDKTFSTERSNISEPDTSSDEGSDAAPAGGYRGETEGKNKDDEAKKKEGERKKKKDQRKKRSDGDSNTRSTSSTTPSTPTSSALSLSGDSEPRSEATTPTSASSSSSSSDSNSDSTPNSPATSTPDTPSSISSNSTDSQPPTPEPTPSPTSSRTDKKNGNRDGAPTGDEEERGYFPNRNADSRGFKGNLLPIRKKPPEPREGARRHWGGDGRERGGGGARGGEGGEGGEYQPNQNADSRGFKGNLTPIRKRPPEPREGARRGQREGGGARGEGAREEYIPPANADSRGFKGNLPPIRKRPPEPRGGGRQPRPGGGTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS11</accession>
    <name>A0A1E3IS11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Microtubule Associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029798.1">
        <property type="nucleotide sequence ID" value="XM_019178079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195224"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000068">
        <property type="entry name" value="cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="282"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="668"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="931"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1587"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1989"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2096"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2164"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1203"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1230"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1596"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1635"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1992"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2108"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2164"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2192"/>
            <end position="2202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN90696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2213" mass="235357" checksum="FEC9B4C3425093D2" modified="2017-01-18" version="1">MDGAPPPEEDFSQIPLPERSQHKNWKARVSAYTDVISGSAKTASDTDPFFQPFIHDPGLLKKWCLDSNAVAQEKGIDAVLALVQYSGETSARLRPELIPSIVEKALGAARAGTKKKGMELCAMFVEVENNGEGVVNDVLGGLSAKLPKAVAGSITCLKEIVEAFGVPTLGNIKPLLKSLNKIFGHSDKNVRAEGTSLTLVLYTYLGPALLPALADLKPVQMAELQKAFDSMGAESKGAGSGKPTRFTRKAQRDREAAEAAGGEDQGGDEGAEAEEEVFDPTSLLDPVDALALFPSNLEAQLGSTKWKERLEVLEECNKVLSDPKNAKLVDSNVDSYGPLAQTLGTKCKSDANVNVVMEACKVIEGLAKGLGKPFGKHRAALLPGMMERLKERKATVVDALGKALDAVFSTTTLQDIVDDVLTSLKSKNPQVKEGTLKFLQRSLQTTLDAPTKDQVKPMAVALVALLGDSAEPVRSTSAECLGVLMKILGERAFNPFIEGVQELQMAKVKDAFGRAEIKYKVGGPKKPAPAAKPAPVAKKPALKAAPPTSPLIKASGKFGGDDVDLNMEFAPPKRGPPARFARPGAAKAPASPASKPAATLEEDAGGLSEMAPPKRGPPARFAKPAAAQPAPAAKAPPAAAPPPKAAPSGKPGAAKTLASSPTEPVKFKYTPEDAAAQAAEVIPADFRTKFADSAWKIRLEAGEEMVKWAEEEGAEQVDAEIVMRFLGKTPGWGEKNFQVSAKVFLVILTFAQKSAAFGKPAAALAIGPLTEKLGDMKLKKPAGDALAAFAEKISLAFVLAQAYEPLSKQKAPKAQADALLWIKQQLIDFGIAGIPLKDLISFVKTALGSPNAQVRQSATQVLVTIKVAVGADISGFLEDLNPSLLSTINSEFDKASSQTAPEPIKGQADLKEVAAGPGKGGKAGGGDPLDDLIPRVDLDKLVASTSVIAGSKSDAWKVRKEGFEALSNVLEVKSNSRLKPNMGEIGGVLKKAMGDTNLAVKMLALGIISKIAIGMGPPFEKYFKLLTPAVASVCADQKVTTRTAAVNTLTVMSEAVGSLDGMYGGLGAALETANPALRSSVLAWLSERLQSEPPSSSSDLAPLAVPIIHCLEDRNGEVRKGATAVLPFVVASAGYDFVMDKTSSLKPASKATIVPLISNARGSAPAPSKPSAPAAAPAPAPAKAAPAPPGSVARVRAGVSGRASPSSPAPAAHSSLPKPSGLTRPLAMKALSSAPSSRPGSSLHHGEDRPSALPKSRMAVPRPMSASSHAPSSAVSSSPSASTKVVPFSTYATEARAARLKKDSMRWVLDPSPKASADLWEYLQHQIEPHAAPELFALLFSKDHRAEEDFMSGLSMIRELYDVQTSGSMGLSDEEVTSLQLANVDLALKYSALKLLGNNTQLSNRCLEVVKEVVDTMTRMNERFSDAEAKLFVPALVFKLGDTKFSARLAPIFESLDKVIAASQVVALLVQFGLEEKSSGKSCKNESLALIEKTYKRRGSILRTRDDRGFYEVLAKCISDSGTRNAALNVMALLQLQGESKSLSAVVQAMPSSSKDMLANRKATMAASKATGTLAAKVSLDSLAPAETASPRLRRPGGLPQPRVNAIASGSSGEGSPRPQGSPRPQGSPSRAIASPTSNLPRTTDSPSQGRSLQAPSALHRPAAQPSQSKLQRPGDVFGSSAAPTAPAPSRPTALQPISRPAASKPRNGHSGPSVLEAINEIRHDDLDKCVDALKNIQSALNQNPNMFVDNIETLADTLMDEMEFAFTPPENLRDPRYFRVVKHLIQSFSGLSSNQDLMRRMNYEQLYAVLNCLSLRLVQADRMGGQIQELSRFINLVLVQCLSTPDRLLVFQVMFRLLLDLTHTFSSTQPDPESELAAHADLVIKCLWKRCKILEDDFKSGRLRPGPILAVLEEFMQGVGPKEYRKRAQQGVTLGDMPLRTVKTIIQRLLVYTRDAGLEIYDILVEQFGDDAASTVVYTYVFRLAGHEPSRPASSRSRSPLLPSHTGSERPDSSASHQTASGVEPPAPAPEAKEDTEIEKMIKDLRSGNQTQRLDALYAFTKANPDKEGEINAALAAHMTPTFQTYVRRMLELRKNNENPSPIREGSSSPRSPARPESMPASLKPLPTMSRKSVGPRPSSLALNVDRSAPLDAQLAQYKNLFRNQALNNSTRSGSGSPGKEGEQSESIGHPSEEIENDSRSARGTPRNSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS39</accession>
    <name>A0A1E3IS39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030008.1">
        <property type="nucleotide sequence ID" value="XM_019177969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS39"/>
    <dbReference type="GeneID" id="30195108"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000529">
        <property type="entry name" value="Membrane transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="623" mass="67477" checksum="DC7FBDF1856EBC2D" modified="2017-01-18" version="1">MRSVAETALGLKHERRDSNVDEDAEDEQLRMEMAMDHEGAEEQGGRGLEETLERVGFGAYHWRLLALCGFGWMSDNSALQCIAVILPRVQIHFNLSSQVVGLLSACTMAGMMIGAVSWGVISDILGRSMPFNSTLFLTGFFGVCASFSPNFTILCIWMFWLGSAVGGSMPTDGTLFLENLPHSKQYLLTLLSVFFSLGAVLSSVISWYFLPGLSCKEFEGCDFSNHANDGWRKVLFSLGIFNLICALARWFLFKLQESPRYLVSTGRSQEAILALQTIADFNDHSISIQHADVQSNEPSAADPSTRRPSFMGLGGEGGGAGEGGSPGAEQDYGGVGMGPERKGIPLQTTTSFYKTPGTVDIEESQNLFDQSFHESISEENRALLNEDSEEPEMKRESASGGGGWAEKPRDWWMSWVGQMQKLFVPQWRKTVILMWIIWGSMSFAYTMFNVWLPAVLESRASGDGDDAITEALGDFVLYSVAGCPGSICGAWMIQTRLGRRKSLAICTLATGLSTFAFINVEQKWAVVVSSMVISAAATAMYAVLYGMTPETFGTNIRGTACGTSSALSRFTGVLAPVSAGFLITVSPSLPVFTSAAIFCMTAACSLALPFERVGGPSTGGFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS89</accession>
    <name>A0A1E3IS89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030024.1">
        <property type="nucleotide sequence ID" value="XM_019177985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS89"/>
    <dbReference type="GeneID" id="30195124"/>
    <dbReference type="OrthoDB" id="10338843at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38473" checksum="0078D289F298BB65" modified="2017-01-18" version="1">MSYRITDYGGQPPQTGSSPLNTPSTTLPAPPNVPGAALPPPVEQQLVTTFRDDPESWIKALDMFRSLQTSFAAVSLQFLRSAFLDIHLQGYVNFKSWSDKLKDLCVRHKVYDVLSGEDIDPQWPRDSDEHDELVYAIILNSLDPYFRRRLPPHFQAYDKMRVDRSQIYPYSKILYTHLEAECRSPMSFADQNRTMDAIFSTKLADQGDAVQHIIRLMDKNQSLEGSGLPIPQNVLCHAIINSLPPAYDGVLRHLESEHRRDTSTITLSYVIGEVEEHYYRLQTVATPPTAVAPSTAKAHTASRKPKVFCKYHRFNLSHTTKDCKKLNAQESLDAPGVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISA8</accession>
    <name>A0A1E3ISA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030044.1">
        <property type="nucleotide sequence ID" value="XM_019178005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISA8"/>
    <dbReference type="GeneID" id="30195144"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="50951" checksum="DB95F12001D03BD4" modified="2017-01-18" version="1">MDFSSMSGKSSMRRKQSNSLLQAFGKPRQSITPSSIPSPTSFTSPPTASSSTLPIDDFYNPSFDNDTTSLTSRSTNYPPGSFVPPGGSRSASGGSFMGGGKDKGKDPEGKSGAVLRRPEDVYRVVKERILSWSYMMEWYTGDSHWLNTVRIPRPVVESILGYKHLENRARNLYSLGISLSALFDIPAASDFLKALLKLLDEWESWSEGSGGKGVKNLFGVRGQRTARKVTGSSMMMSDYAPPDGAESYLLNVNLPFTPDYFQVHASTCSIVRDLYRKLLNMFLPTSPAFPHSSPTLNLPSSHVSLIHHSTIVQTAPREPFINPKSPGASSIATATFSSQQGHGIMSPTAIMSDQQGGGGDALLAFIAGDVPPDRALVGDGQKLTPQIADLFQKVDSKLKKHFSILTREADSLAKRVVDDQLDTLLRSLSPGGKAMRFDVTPGSSSGGSGYTTATIGRSGIMESDRERDFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISC1</accession>
    <name>A0A1E3ISC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029918.1">
        <property type="nucleotide sequence ID" value="XM_019178199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISC1"/>
    <dbReference type="GeneID" id="30195345"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000007">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="130"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="48485" checksum="776B1723C3C27D12" modified="2017-01-18" version="1">MSSTATLVNDDRDYSSAIANLKIRDIPNIPDISKVTQVELGSSPDSDEDDAGVNPFQYVGEVLGAGPGPNYPYQDLLPSNPTRTKSDPPLELQEFSDRGLKADPNAARLRAFVQARGGKVKDQLIAIGTVIEGDIKLEELGEAERDDLALLVAQRGVVFFRNQHTMTIDQQRELGAHWGPLHKHATYAVPRRGDLDDVVVVYADHDSRPDLYAFSRAELFHSDVTYELQPPGTTILRLLTTPEVGNDTLWSSGYAVYSSLSKPFQKYLESLSAIHSGFDQASSRTGITKIPRREPIETVHPVVRVHPATGQKSVFVNPGFVTRLVGVPKAESDTILAFLKDSFAQQTDATVRWSWQAGDVAIWDNRIVNHSATFDAYPSLRHGTRVTPIGEKPMGVEEYEERTGEKAKDWLEERFRKLGIRGPAKDDGRTKQRAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU40</accession>
    <name>A0A1E3IU40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030254.1">
        <property type="nucleotide sequence ID" value="XM_019177870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU40"/>
    <dbReference type="GeneID" id="30195004"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="64138" checksum="07AC66A994FA5D4E" modified="2017-01-18" version="1">MSAHYALRQPHIKTPGSNSNFFNTNFKASAGHRQMSTPAARLNLSRPVTRALLVGVFLLGLILLTRSTGESQEGAWDTSTIHELRAGGASVAGRSSWWNSKPKLVTDVRVPRPIRTRQNTTLPRPTHPGKSRRVKAGSDPDDPQYIIRPLPTLDEAWAFLHPLLREAKEMTPEVPREHELTEPIFPPFLTADMEERFRHLRDVYDLSTGQWVRGPERRWFMVTVCRQVAGMLADWFAAWTILADFLGPESLAFSLIEGDSQDGSGEILAHAMRAHLLNIGVPPANIHIQTGMPAVDWDASHRIELLASMRNAGMQPFYDTMPEGLAPDGHPWTAVIFFNDVYISATHFLELMHQHFKQDADMTCGWDHAGKWFYDGWVGRDMSGDLYTPFPVKEEDKDLPQKLFPSSPETLRRYNRMLPFQVFAAWNGVAVMSAEPFLPPYNVRFRRAAARTDDFWECQASESSFISWDFWKYGFGRIAVVPGVHATYGKEDAMMRGWVDFPDEGDGQVAEIRWNDYPPKRVRCHDWPDKPGKGYWAWDTVRWVEPPPLETPLREDEYPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY37</accession>
    <name>A0A1E3IY37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030563.1">
        <property type="nucleotide sequence ID" value="XM_019177410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY37"/>
    <dbReference type="GeneID" id="30194536"/>
    <dbReference type="OrthoDB" id="10338405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="38052" checksum="40826D7D9D75BE09" modified="2017-01-18" version="1">MSPHIPRADDAHTSDGGSDPNASFMEKYSPWSYVILGGVCAAVLLFCLYALWRGPQRAFLPLDALSCRRKKNKKALTASPEREQGVGQSAGQKKVYLTDVRRAAHTLHKKPPPGILNDWKNQQTPNPMSTERQKGEIGRRAGGNASWAGTISSFGHPASMMDTGTRPPLQRQVNGTQTSILSGSDRLEMFHTPQSRMDGQSWALSGPHDSVSSTSSLPSSRSVFRQQTYTPPINNKPTIGRSHHSYSGSTPNLTTASPNTSQDIYAPSPVHVRSRSTGTSPMVPSPLGTPPLPTARHSMAAIPSPRLGPRVQFSSLLLPKRDVPTGSPLATTPPTLPSAHSPSHDRGQELGVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J071</accession>
    <name>A0A1E3J071_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030743.1">
        <property type="nucleotide sequence ID" value="XM_019177162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J071"/>
    <dbReference type="GeneID" id="30194279"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="246" mass="26325" checksum="9B11F4EBAB50C82D" modified="2017-01-18" version="1">MDLVFPPPEEPSILALPLPHPEAYEGEPREYALALMQRRDAIQKEIDVLTGVLTSHGTTQSTSLVDNEGYPRGDIDIYAIRHARSSLVRLQTDRQTVNELLGNALNEAFASGSSDSTQPNGNTLAINGHPPQPRAQSAEAWPEKAVVKVNSVAEGSPAAEAGLKAQDLVYSFAGITHASDAALQAIAAVVSRSENAGLNPVCDRADLFQTALPLLILREQEQIRISITPRNGWGGRGSLGCHILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D7</accession>
    <name>A0A1E3J1D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030938.1">
        <property type="nucleotide sequence ID" value="XM_019176906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D7"/>
    <dbReference type="GeneID" id="30194013"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="74"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="577"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="760"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="724"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="809" mass="90364" checksum="449ED44EFF04CE50" modified="2017-01-18" version="1">MPKSRASRGILLTSNLPQLQNLIKRDPEGYREEFLTQHNHYLSLLRLHTLSSNTPSSSTNNDKSNDLFADLITFCCQVSQCYPEDTKDLPAQLRGLLLGGESGSAAVGGDLRRTAVKNLVMMRNKEIIDSIQLLQTLLPLLPTVPSNLRGMIRHTILTDIKTSNLKTKNHRLNRVVQSLLFGMIESGMGAEVVGDKGRNKGKAGREKGGEAMWAVMMVKELWRKGIWKDAKTVSIVALATFHPNTKVQSAAMHFFLGSENEDEDDSDDEPDVADARRDVRKMEHRAQVGHKNRKKVTQLEGLKKEENRIRKKKVDMAGVTPNFPALELLHDPQTFGEKLYDNLHKHDKIYSLDHKILIMQLLSRVMGSHKLCILGFYSYIIKYLTYHQLQVTLILVSLAQSVHDLTPPDVLTPAIKKIAGEFVHPGVGAEVIAAGLNAIREVCRRQPWGMEEDLLGDLIEYRKSKDKGVVTASRGLLQLFREVNPGMLKRRERGKAAAMGLIGNQVLAYGHTAETPSGIEGIELLEAHLRQQRKAAGDEDSLAGSDVDMQDVVDEADEAGWDKWDAESDDDSDSSGWQSVSSGDEDLDISDSEDETDRKRDKREKREKKRLQRKGLKKKEGEEESEDEGEGEDEEMDDGASVAPTEVSQATKKLSLLAQQKILTPADFALLNELRLKAAKDLAASGGGSAAKRKLAALEASKRHVDTDESDRFLTDADILGPRKKAKATWEERMESIQKGREGREKYGSMKGKKKKDAPSSSTNKEKAKNKPLMMAVHSDKVMQKKKASLRDKQIRLRAAIDKRKKQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2I2</accession>
    <name>A0A1E3J2I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030692.1">
        <property type="nucleotide sequence ID" value="XM_019177111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2I2"/>
    <dbReference type="GeneID" id="30194225"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16770" checksum="313B9775B27AC75F" modified="2017-01-18" version="1">MAQQRKTVGNSSRVACKQYAAQMKKDVLGADEEQKAMRKKEGVMRIQALPTAVVHGSSKSTAKAFQEKLWELPDNMTVYPSDQNLEQVLDEVLSQLKSSWTALDEENGQQAGFAKHKFDWPKEMKTGDSSSVKFSSLPTKDLGQRHQHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J329</accession>
    <name>A0A1E3J329_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031234.1">
        <property type="nucleotide sequence ID" value="XM_019176759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J329"/>
    <dbReference type="GeneID" id="30193856"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130175" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="183"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="52857" checksum="FD830706BB819DBA" modified="2017-01-18" version="1">MRFNTALLWATTALHLSALEAGATITGQKWCNKYLCVTGQHDSSQKIDQYTLEPPEGDTIPLSSFGWMAIGFGSTMADTPMVIGWPNSDGSITLSQRESTSHSMPTVVSSPSREATLLSSASFSNSSTTSISFTLPSNSTVSNGTSIIFAVGSTNPGDSAEDATLKQHSVSGNTKIYLLTPWSANSTGSSNTNSSNGSGDDDTSSADSASSKRHKMLIAHVVCGAVATMALFPIGIITPRIARGLTTSRWWFPVHGAVNGMLGFGLVVAAFGIARGNFDGKFETSHRKLGLALFILCIFQTFLGIYTHSYRPTPNQKRFTTSSGRGPSNFIHMALGLVVVAIGFATVWEGLDEEWEIWSGTGKPATGWKVGWGLVVGITTLVYLAGLYLIPRQLHNERQRRNLSSTINHPNPSANYGAPPPGNHASSVRGDFPLMQKDSNSSTESGEQYGMGYVPRQGHERLPPPPVTVQPQQQRRLPPKWVPDSGRGRSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J353</accession>
    <name>A0A1E3J353_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031270.1">
        <property type="nucleotide sequence ID" value="XM_019176795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J353"/>
    <dbReference type="GeneID" id="30193894"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8851" checksum="9C639106AD29E597" modified="2017-01-18" version="1">MYNIVDVPAGVFPTGLKVDSEVDDLKDDGREYLSEMDEMVATAYDTKIMAGAPLGLQVAGGRWEDEKVMKALGMISEVVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J375</accession>
    <name>A0A1E3J375_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031290.1">
        <property type="nucleotide sequence ID" value="XM_019176815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J375"/>
    <dbReference type="GeneID" id="30193919"/>
    <dbReference type="OrthoDB" id="2572645at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="317" mass="33957" checksum="0D8C6C4F17C3A639" modified="2017-01-18" version="1">MPPIAIRFLVPPPARDGRSAHRPHPYIVLDKTSPSSPSLPTPPASEGDASSRRSSSTTILNANAPITPASLSAPKPSSASPMSSQSRKRKASFVLPSPTDQAGGEGKKAKMMVVRMKPDFGTILARCAAYDPTDDGHTVKPTHSSATKTYLHPYSPASDWGNFRSNKLSREEEVREERMMKAKKMGKEEKKTKMEGAMRVKELVKEMKVTLGGGVYVPPTVEEVVVDTPEGTPRPTTAKPGRGKKSLSPASISTRAKSHSPLATETPLVADALANPPKTVPLAAGKVKPGRPKKVTVVEAKERPSRSSGRTKETEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3D1</accession>
    <name>A0A1E3J3D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031155.1">
        <property type="nucleotide sequence ID" value="XM_019176680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3D1"/>
    <dbReference type="GeneID" id="30193775"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="221"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="622" mass="66836" checksum="1366DD3EDE9C709D" modified="2017-01-18" version="1">MKPPSTPPTHSSPPSYSPPLVYPQPTKQPSKGSAAVTGTALDAGGSRGGSVLGDVSGSATPTHPGSHVVYMEDTESASEDDTEPVHPAHAIPFHMRSTSVPLSRTSSNASSLAEEGEATPLLLSQDEDGGYKGKWYQGPLFVAAVKLGILFAVFTLVVVGTFYFGMPKMDPEDKGAVKLPRSFADIQALNALFQKYKHKYPVQILACGVVSYLFVQTFSLPGSMYISILFGAAYGIMYGLLLSCICESIGSLFCYSLSAILAPPLLTLPFYRARVETWRTKIMGDPKSGKKVTWDSIFAILLVLRIAPFPPHWVANFVAPHLGIGMFLFWSSCFIGIAPVSVIHVTIGSSLDDMTSAADFHILSLRNILGLSAVIVAVLIPVGLKRIFKKDLGDLGEAEEALAANSNNDREITVPHIGLGSTSPNRGGGYMYHAIDSGVVLAVPSRGDGVDMRRKIVRRGKGRALEIIPDDESEGSGEGEGETLEMAASPLALSDALADAQQDPTLYEADEDDDLYGPSPVAGPSSHPSNAPTPSPFAASEYQYRVYDPSNRIESVHYKPRPLSRNSSSYRSSRRAGAVKPHRPNTLQGYGSVEAPRVPMEIREEDRATRAGWWPWARTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3X6</accession>
    <name>A0A1E3J3X6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031345.1">
        <property type="nucleotide sequence ID" value="XM_019176870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3X6"/>
    <dbReference type="GeneID" id="30193974"/>
    <dbReference type="OrthoDB" id="10413493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="40593" checksum="D5B226893C791A46" modified="2017-01-18" version="1">MAPPRPSKPTRRARRSRHPRDPSSRIELTTLEPLHPVYYIILDHLLHMAPATYIRLSKGLRDYGTARLSAPFDFDDQLVSRFHESVKKQQDVRWLFPITQSRTIRFPSYRLFATMVCLLSQVERQKRRTRKAGASYPCQYHPTPLFARATSMEIRLDEAVPLRSLFQQINAQLQLTNAAYAYGDMTSHVGPRFRNLVLHHISDSALSTLIRDCATNYRNRHICEISTCLCLYTTSPVLTTTVKLSISDSRFPEPSALSASLTSLLRSLTSKKPSKIIIDISGPTHSSLRQAVVDAIAKHISMMADSGYLSQAKMMRFEMTGRYELYARVWKKVRERRYGKDLMRVLRSIYKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4C2</accession>
    <name>A0A1E3J4C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031090.1">
        <property type="nucleotide sequence ID" value="XM_019177058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4C2"/>
    <dbReference type="GeneID" id="30194171"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="117" mass="12931" checksum="7A2D5191E2D62B73" modified="2017-01-18" version="1">MSQPIELEAPIQPKEGEPGFVGLLVKSVFEPGANAAVVLAMNVCFFFLILTLFGLAVLTQWNKHVLLLLGVTTLLWAAMAWFVLELTRVQNHPSNMPLSVEIPEDEASLSDELKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4W0</accession>
    <name>A0A1E3J4W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Superkiller protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031542.1">
        <property type="nucleotide sequence ID" value="XM_019176614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193709"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1525"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1527"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1552" mass="171376" checksum="10AA35655E2A6818" modified="2017-01-18" version="1">MSNKKALKSIQGHLKEKNAESALYEATELLKSIDHEDTDAAQCLVFRGLALTQLEKLDESEKSYLQAYKLQPNNPLAAKGLTMLYEKTQDWDKYGLFLENQTQGMYDSGDAEKLAAALERLISIRQEHGSEEKLYKTLELLLPSSPLVPLLQSVEASKDSYVPIAIPEYPTPANKLPVLPPLPHPSLIAGSLAIALNVLIRFETALSAKIAARVANDRKRINAGSEAEVRKNVDREILATEGLKLAELWKEVGGHPAVEDDIRRQVEIKELNFWRRLVACLDAKPKTAARPAAKPSVPSAPKLKLAVSGLSEPALFQEKKNLVAPTKQEALDHADGLANGFVLLGVNSAGSEEGWSWALEGKDEESIYYDIDLLHKYACAFPFSPLADFIDIYCRWFKRPSPEYEQEKDNASLQERTQFKKHKGGKASRARRQVRREEEGQDEGKVVVAEDVEQEEKEEMISLLTKLIVKLPKSLFAYRAMARVSLQDEDLPNAISFAEKARKLVKEIESQRGIALPNAQADLDTVLGVALVPYFPPKHHKRATRILETVLTAKPENIEARFSRAQVFQYAGDWTSAREHFQQVLDSSQDEKAIITAKEEVGWCLVNEGKLEAGRDVLEEVVGIRDGKSEREKEGEAKERGRAWYRLGQTEWRIGDDEAKANAEEWFMASIRANPSHAASYTALGTCYSSANPPDHERALKCYQRAFDLDATEAYAAHRLAIGYANEDEWAQVRLIAVRVMEGEGGLEGVAGGEALGTKARFAPQNGWAWKALGATEMHYKKYDKAAEAYQIALRADPEDVSTWVTLGEAYVKCGRHTAGLKTFSHALTIDPANWRALFNIGQTQSQLGAFDKAIEAYGQVMDITGGEEVGIVAALAEANLASGRQTAAGGFRVRSRGAFHRAIELAVKVLKTGRTHRAWAWKLIGDATFELSWQESSIEEAQASFEYVQPVLQFLVEDDADQRSNAPGVGHAANLLQEAVSLSTTLKTAIFAFAYRAHLLKNEPRVVDPALYDYASALHTLAGRLDDGEERKQCLRTAISAIRTALDRDAGDERLWNALGVICSTAGPQLAQHALVVSLELYTKDPVVWVNLGYLYLRLDDRELAGRCFLKAQVLDPDYARAWYGQGLLADRNGEKEQAKALFSHSVTLSAQALLEADLALAAATFARFLSPTSAIDAGILHQPAFALKHYCHQRPQDYTAAHLYALICERLGLVEEAVSSLERTAIALEEEFERAESAEIEHFYAVALCNLGRVRLSTGQYEEALEALDNCWELVAGSSEAASATLKPQCKLLQGLAHYWLGQTDESLESFQAALDEATANQDMEVKEEVAVLLSRTLWGLGGKDAREIAKSNLLECLSRENPSLRVISTLAAIAVVSADSDLIEASMSELLSRPISERVQDSSDQGDLVLYLHNLAEGQEEEAYEVLQDAARAAPGSQRIINRLAEALIKASKAGDALKILEVPGGKNGTVESKAEEDRLRGLAELLEGEGKGLKKLKRSVMLAPWEEENWHALAWGKKVADEAGLEEEEQQQQEEVEQEEVQSSVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6P1</accession>
    <name>A0A1E3J6P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031758.1">
        <property type="nucleotide sequence ID" value="XM_019176348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6P1"/>
    <dbReference type="GeneID" id="30193439"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="33305" checksum="2D6B6A612EF7DD5E" modified="2017-01-18" version="1">MAEPQQSDAAKKAAARRAKILARVKPASQPSPPQAEPVQPSWAPPPAEPKAPRPTASASPQPQMSSEQEAMARQMEAMMSMFGAPGNGAAGGEMPDMSKLLSQMMGDPSLAGGPAGQNLLGDMDDPAGLGAFGGAGGVPPNIFGGADGSSPFPFPGMQQQSQGKSKVARYFPLVHLVATLFLALFAVLWWEPALRSASAYQEEATTWSERWSGFSGRRVKGLGEVEVLPLFLAFVTVELILQSSRLMIFRSPPAPHALLQNFLPVLPQGIARPLLTGSRYLNLLNQTYKDGCLLVFAVGMTIVGAEWLRGSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6P6</accession>
    <name>A0A1E3J6P6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031789.1">
        <property type="nucleotide sequence ID" value="XM_019176379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6P6"/>
    <dbReference type="GeneID" id="30193471"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="617"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="809"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN96543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140627" checksum="2F3D0257D0463477" modified="2017-01-18" version="1">MSREWALRVALLHDTLLQSAQEKAAAAAKSHARAQSNASLSNISSPQSSSQPSASALGIDFGALLKRDAKSPRYPERMIKGLDGLLQRVAMGKETKYSDARFRRTIALFWSSNWPEKSFQRQLKEDRRVEDLILSFTSVSAKSLKKEEGLGDSGWKEELNVQVSLFIDMIKDALSAISISWSSSEPLRQRLEQYQTSLRSAPKDNGDLSRSKSNKSVANSIGDRSSVAAVPETPKYTQGELTKVVEVLYNWPKDELDQKSDELRQTCTPQAAVNDFKTILKLLNTEKSYPYSASDFLTQAKWQTWRGQEVSTLSQVMLLMMQADSSSPDQSSTSSITSQFENLNLDTFTPSFTFIPPNARETYQQILENCLNADLDALEVRPDDEEVPLTILSENHTLLLKECAERWRLTPEFCSWAFMDAMIGLYEAGDVPVDCVLEATSMINKMQVDKPSSEWAAPELEGLSKAINRRDGCFLSSLITTVTQAGYLSEDFISAVNNWTTVSSSGNQLPQAKQTLEHLLSLVKSQASDRYIDEAVDKIRHEGSKTYEFIMQMAAWVEKETKRSCKKFTESLSPDIDLVEYILDTHWNIWLHDLKDTLDLVPSEARLEALDDDFMLFNKATKLDEMRHAMSGGYGGHPVAPADPPISSLFHNTVNLWLDSVGTKTRGWVDSALMADNFESTVENGPSSSVGDLFDSLTSAAEFLMDLNWPDEHQLAEYVTRLARVIGTCINDYCTTLEQYFNIAMRAVETSQTEEKQKVWMEKAKATLASMQGEKKIQAFFNFTPESCVKLNNIESARHRLDRLYTLLRVDELSKLTSPVKPANRTQRYLFTVKIVLAEGVVFDNGSGARQPDSFVILSDEHGKRHHKTRTVYDDSNPRWDESCDVIVNGTAWFMITARHRNLTGKHDLLGRAYLQLNPADFENEVLKDILQPLDTRGVVLLRISMESERDDMEFHFGKAFRCLKRTESDMVRLFVDRMTPVLRHTLSRAGIKSVLKSNNPQPQVYNEALGKISAVYKSAIGTPDYNIPAPHDHTRGRGPSDEDIESAIHPLFDYLDTNIHTLASTLSSNAMQMVMTKLWKQILMTIEGLIVPPLSDKPSSMRPLRDAELDITLRWLKFLKDFFYVGGDSSGVPISILQSPKFNEILSVRIYYDWATDDLMEECVRGFQSTLQYRATKRMKSVKAQRNLGTIKARKTAKRKQNKDGGNAEMIMRILRMRPGTQEFLAQQLLAMSIVKLRNSKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J783</accession>
    <name>A0A1E3J783_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031781.1">
        <property type="nucleotide sequence ID" value="XM_019176371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J783"/>
    <dbReference type="GeneID" id="30193463"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="413" mass="46686" checksum="F4C459ECB463D903" modified="2017-01-18" version="1">MADVNEKIADPKAERRASTTRYLKLNRLPTLQEVLDRRTRPPLDLFCFYIFLQREMSEDALDFWLDVQQHENLCKAYFKDLRRSGRSVQDEWPQFADYARSNGSHFSPLLSLPSEPPSPNPTSPNPLYPVSPDQAGDFDPSHSPLNPSGSRGRRDTESHGPNHGMTSPTPSQGVGAFGERAQKEGRTSLAPSQGAGTRSGRRRSKAPTVIARDRAIEKQALQESAERIFYRYLFDGGEREIYLPPSLRVYNFPESIEGETSPLIPDLFHAQKIYVFKALEQDAFPRFLRAKAFANLTPFGSVVRLIAGLLCLWGAFVLAFSLIFLDWKPRLTRLWLILPFLFAFILLLSSYYSLSPLLFLLNLSETTPFHFISVKEPYVRKLVAIRAGIIVVASLLLTAIFVVIFTVVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8T8</accession>
    <name>A0A1E3J8T8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031881.1">
        <property type="nucleotide sequence ID" value="XM_019175968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8T8"/>
    <dbReference type="GeneID" id="30193055"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="598" mass="67298" checksum="D0F02E6633D80B44" modified="2017-01-18" version="1">MSRAAPRPPSALHPAASPPPTRRLATILSFPALFLLAIPFWWYTTSIERLPLPESRIEHLTSTDSPTPHAQILFTADPSAFPASPPGRHQYETKEILQSLGREVTKGVDGIYARKPEKERDIRRWDFVYTGDQEAQRTPLRVHLRRWEYANSSFPLEPYVQPAEIHYKIALINSILSVFPPNPPDLPLRALKYTPNITLSFVLLNEDATEGSYVRGWDIDQAIKDHFLAHLEPLRPVFNFTIESQILFHAPLSFEPRLGLIPEEEQDQAIDEGVESVNSASATDAAKGAEVGAFISETVDKRGERVWVIDEEHLKIFVNSEKWSLDSGSTNNPVLRFLLYVPSKQHRPMRLASPDSAHSFLLPQFGGVVVINPPETSAPAYHLSSPALTPAFHLFTQHLYSLLALPRLPYETNKLHIPPASSPFHPQSISLQPLTPWQVHQVELARMRENAVEARKTLMGIVRLVRKIVEMKVGEGVRRMVSGAVSRLEEAQRTDGRDVLETFTLIRDAVTLSNRAFFDPSMMGLFYFPDEHKFAMYTPLFAPIAVPLILGLIKEFVAWKKVKSQKKHALQDEGKEAGGDLRPVEGDVDEEPKGVYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8U2</accession>
    <name>A0A1E3J8U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031864.1">
        <property type="nucleotide sequence ID" value="XM_019175951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8U2"/>
    <dbReference type="GeneID" id="30193038"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="195"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="30012" checksum="B39CCE819278F1F4" modified="2017-01-18" version="1">MPRSPSPRRSRSRSPQPRKKAPKELSFYKKSSAPVGSFSSRRDPLDEPSSKERAEARERGEVPKRFGGSREQGVRNTMGNVGASVGSFRRGGDPLDRYGVKGEREDRRDYGRDSRDSREHRRDDRDRDHRRDRDRRDRDDRDRDRDRRDRDRGSDKKRDDGPSLPAPTAPAVGSNGGPPQRPPAAAPSMASLRLIEVIANDRMGRKVRVKCLPTDTVGDLKRLIAAQTGTSAQKIQLKKWYGAFKDHVTLQDYEINDGMSLEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B9</accession>
    <name>A0A1E3J9B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032070.1">
        <property type="nucleotide sequence ID" value="XM_019176157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9B9"/>
    <dbReference type="GeneID" id="30193248"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130201" evidence="1">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="506" mass="56960" checksum="50C999E3860A54CE" modified="2017-01-18" version="1">MRPLFHLILNLLKLHPHIRATILLSPATSDRMMKDLNAFINSEKKLQSRGGTGSISEHLQVVTCGKDSTVVYDAAAAQKDIEHYSIVLPGFIKGIFSGERDLGYGRNNRLESMIPTKIIMDMCQFTVPDILRKAVSEVDRPMPPVLVFCPISFSAMYSMFVTNGLQGMYGRVLKNIDRDVAAGIPVKDAYAKRSFDFPGEVVQFIDIPYKYDYELEPHWALQEIPAESLMAFFPIYHTMFDPIVSGFILPFTGEFEAETIKVIEKEMGKPLFSVGPQVPADVWGNTLQREIASDDDRKALTFLDDMRTVHGPKSVCYLSFGSLYFPHRRPDIIRWMLQTLQEAGIPVLFALPSGLKAVPQDFLDEFKDFKDYCHVTFAPQWQVLNHAATGFFITILAEVPIVAMPFFGDQGEIAALLTEVFKIGIDIKQTKTFANPAHNTLYDGTKIVGTEDVIKEEMRGIWVRMTGKEGDEMRKRVAELKQRIKQSVASGMIGRDLTKIGLGEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9K9</accession>
    <name>A0A1E3J9K9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type H+-transporting ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031957.1">
        <property type="nucleotide sequence ID" value="XM_019176044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9K9"/>
    <dbReference type="GeneID" id="30193131"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="243" mass="27481" checksum="72C41B1CB85A0E56" modified="2017-01-18" version="1">MSRSGALDDNEIQSEMNKMVAFISQEAREKAREIQVKADEEFAIEKAKIVRQESLAIDAQYEKKRKQAEVGWKISQSTAINNSRLKILQSRNDHLEAIFDESNKQVKDLSTSAKYNEAVESLILELLLKLLSPRVHLAHRPKDSDLVKKAASAAQKRYKEIAGRESELSFDDSLADDSAGGVVGSTLGNKIKVDNTLEERLKILEEKMLPELRHDLFGPNENRKFYTVSLVSSEMHRLANVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBF9</accession>
    <name>A0A1E3JBF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032048.1">
        <property type="nucleotide sequence ID" value="XM_019176135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBF9"/>
    <dbReference type="GeneID" id="30193223"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="24282" checksum="781C23C4FE9B9C13" modified="2017-01-18" version="1">MSGWMSYFTGRKDTREGARDAIVGLRQQLLMLEKKEEFLGKKIEEEMKKAKANATSNKRLAMAALRQKKAHENELDRIAGTRLTLETQVNAIESANLNAETMVAMKKGADALKGIHSNLTAEGVDSTMDKIREQMDLTNEISDAISNPVGMGIVMDEDDLKDELDALEQEQLDDRLAGADRVPSHLPASPVGQTTGRAAVQEDEDDEEAQLRQLQAELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBJ3</accession>
    <name>A0A1E3JBJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_03492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032112.1">
        <property type="nucleotide sequence ID" value="XM_019175622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBJ3"/>
    <dbReference type="GeneID" id="30192705"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000017">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="49323" checksum="D5AAB795F7B36928" modified="2017-01-18" version="1">MSVEEVALTSPGPFEGPEKLLELWFAPSLAELPDAPESSLAGGLKSRPVKDGEQWKGLRKVPKEVWEEMLDIVKCKVLSTVEGDDLDAYLLSESSLFVAPHLLILKTCGTTLNLLGLYRIIEIARQYCGFNTVYRCFYSRKSFFFPERQQGPHRDWRDEVQFLDRVFGTAGAAYTVGPMNRDHWLLYLTTPNSQPILPSDPSPSSLPPSLPPIPAPAALPQPTTQYQDTTLEILMTHLSPQARAPFFHESFADQASTTPGHVLGQAISSTLGIDQLFSKEETNLDSFGFDPCGYSANAVIGSGLPESSSGKPGGGYFTIHVTPEEGWSYASFECNVPLPTSSSPTEGLQNRPDLQTLIKKVVNIFQPSRLSITLFVSTPSPSPTAEEEEAEKKAWNSFGPSLLGKEFVRKDRIGYEFDGYDLVFACFEKKGWVEPKMVTEKPAEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBJ5</accession>
    <name>A0A1E3JBJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032110.1">
        <property type="nucleotide sequence ID" value="XM_019175620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBJ5"/>
    <dbReference type="GeneID" id="30192703"/>
    <dbReference type="OrthoDB" id="2559962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="38744" checksum="329C2B7D7962631C" modified="2017-01-18" version="1">MSPSSPLIAITGINGFIATEVVLLFLARGWNVRGSVRASTQAEKLKSLPAYEKYFASGQLEVVVVEDLAKADFTELFQGAHAVASLAAPLPKLGDPTLTWSDFKGPTIAPVLRILDYAKKSTTIKSVALMSSSGSSLSLEQEPNKVYTEDDWTPYTEEYCDNPMASVIWYFAAKKFAEEAVMKWQETEKPSFAISTFCPPMVYGPAHYIASLADLKALKGSTDEFLNLFIGKDQPFPGQFSKTFVDVRDVAEAFYLGITKEVSGKYLVSGHDYCWQELADKLRELRPDLDAYFPLGEPGTRIKGEWTMDASKSKRELGLEYRSTEETLKGTIDLFEGLGLFKEAPLGAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBP1</accession>
    <name>A0A1E3JBP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031933.1">
        <property type="nucleotide sequence ID" value="XM_019176020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBP1"/>
    <dbReference type="GeneID" id="30193107"/>
    <dbReference type="OrthoDB" id="5541797at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN97331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="32490" checksum="6DC2E9357F4FD668" modified="2017-01-18" version="1">MRPSVMLRGVAEDASSHLAKISQNAPSHRPKLVSRFRAQQLSPNKQPKFLILNNVPKLALPQDVLRALQDAKAVGKSFPLSSITALPPSLPRMPSLTRKWHIEIEGPRQTLAIHAHVNAHPLFATSSSTLPYPTGKSPNRNLNLNPKLHMLEAAQLSWSTKEEWTEATIEMATRNELKGTRGVDWRSTESWKLTVDWALQPEFRGRRVVVRGLPGGVTVPDLARLASGCSLREAKDAIMTLPPSIYSLNTTCCFTLASVADAHRLVRKVHMKWYKSLIFGEEYLMRAEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBX7</accession>
    <name>A0A1E3JBX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032216.1">
        <property type="nucleotide sequence ID" value="XM_019175726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBX7"/>
    <dbReference type="GeneID" id="30192811"/>
    <dbReference type="OrthoDB" id="3353448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="104" mass="12120" checksum="22E3F0EFAAD792CF" modified="2017-01-18" version="1">MPFRTPRTTTHHHHHGVYRDNRARGLRAAINNPRTTHAGRDNAQHELHAMGMRSTRPGLGTRIRHFFHLPAKSHNRRHTHRAHTTAPSTTTTTTSTHHRRTHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC47</accession>
    <name>A0A1E3JC47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032289.1">
        <property type="nucleotide sequence ID" value="XM_019175799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC47"/>
    <dbReference type="GeneID" id="30192884"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027246" description="Protein kish" evidence="9">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8660" checksum="A27C0329565D30B1" modified="2017-01-18" version="1">MLTNITQSALFNFQSLLLVLLLLICTCTYIRGTAPNLVDRNREGFLGLFFKFARIGERLSPYVSLACIAMALTIMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC52</accession>
    <name>A0A1E3JC52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032107.1">
        <property type="nucleotide sequence ID" value="XM_019175617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC52"/>
    <dbReference type="GeneID" id="30192700"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13645" checksum="A35D7B5962FF127C" modified="2017-01-18" version="1">MYKYQLDEVKTQLAPGARLIPPPFSLPTPTPGDGLAAYAIRSSPFSPLSLLAPRSYHSVSCAKLMNVSSNEGGWQTGMIMHMVAYKYKIYAQLFAWEQDKAGQARGKTWSLRAIMADYDPWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF08</accession>
    <name>A0A1E3JF08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARF guanyl-nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032545.1">
        <property type="nucleotide sequence ID" value="XM_019175442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192525"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="912"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1661"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1703"/>
            <end position="1716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1812" mass="198110" checksum="AB46C9B59C3BBF08" modified="2017-01-18" version="1">MDYNPEAGPSRPRPLEATPPSTPTASVKAKRRSWFGIASPVTPLGKDKGRDKRRESVASTEELELSPVVTSRQDESFDEEGLPNQRHGQDELLTIEGELEQTAKKKKRRSGGVEELQTMRMEDFSSKNSSRNVSDKTVVPSDVDHAPHPFVSRASLRAASDRDPFSLTETPYHPHHHSEAPHMLSSSGEDAPSSLMIRPTPRSSSLRSTPSPNVPLNIVGKLQPPLPVNIDRPLPPLPPPVSTQASEAPQGPSNIVITPSTPRKLTKSSTTKRAQDGERRSRSAGRPRSHSRKRSQSTDAPRNIGLGLPSVLSGRSRSTSRARPSTSPGLQSPPPPVPSKPQSVSSPFPVSPFPSRPASPSPRIAFVEPTIPTDERMQSKEAEGERRGRVKRARSLSGLFGKTSPMVPTAKVNESPSVDISSEAEEGNEHSGAGRVGVLEWLGVRKTVKRKTSQIQLQDKETETQQASVDEERHVRSPPQDIPLQAPPPIQASSSESQRSTPGKLSSIFNRRTTGRNNADETEPLSINVARSNAKKDEHPPPSSSHSQSSFQLPTGNPVSPFVPEGGTAWVSSPGTDHEEIIHSPGGSTHWGPGVRPWMDVTDHHVSSRNSVASALDTLPEQEQLPAPQEMSQPNNSGPLKALAKFGEGRARSWSDAPLPARRPEQTLISSSITSRETPTTPATPVTPNTPQTPSSPVGEFKVPIRPKVGSRQNSGNSVILGRMKSVFSKSTSRSRSNSLLRQRSGDVDEFGGLVSQRMRPSTSSSSVASSVPGRNTAVTSDEPQAEPQYEGKILAGAERPSRTSMTPSLSSNNSSHRQSILLDPSHAHKPLPHRSRVRASTVSLAPTSYHFTPSSPVTFPTAATPPRRQGTIRRLSNGLFGGSTSPQPASLFPLPPRSSGSTSSIGTGVPGDESSFGTSPRPSTGSLTTKPKALKEAAIVHDEETPRHWLNRVIATVGRGEISNVLAASGDDFHTDALRMYMEDFDFSHSGLDVALRKLLMQMSLPKETQQIDRVMEAFAKQYEVCEPGLFDNAYVLAFSMMMLHTDAFNKHNKNKMTKADYVRNSRMEGVPPFVLETFFDNITFTPFVFIEDDAELECKRSGGAVTPSSFGPSTPNFSTLLNASNPSNKLKVDVYDLIVRDMLDSLKIDMSKEVPAESPFSCMGTRPFLDLNALSQTFATAHNLLIPAPQLQRKGTGKMATPGKKQPGRAHSEGDMSLRVTKVGLISRKDEGNGENSKKINRKWKSWSVVLTQSQLLFFKDPTWALTLLEARAKDGHLLLPRMAMFKPDEVFPVKDCIAVFDQAYTSQPNTFRFVISHHQQYLMQAADEFEMNEWVTLINYASAFKTAGIKMHGATMRKDQAVLAGAAAAASHRRDLRGGESQSSLHNGIGSSSGRRAVFGDPGIQSGLQPMKPSTGEVRGVDVDGANERLQEGEQLEEVFGVVKAELAAGRGGAESNPASRKQSLQQQADSPYSHVSRVAVIENQLRVLREKVTPVESAIRSSLLLARNIQLLTPFQKSTRDHLSSLVPSIARRVRTERMTLSKLHLWINVLQWEAEREEREWKEVRHVALQAAARSLREDGVRGVVHDVARDEGEGRSVPVLELPEDNDDADDGDHFSTSPGELPIMFRRPSDDDRDRRWRPTSRDTTISITTTSTAPNSRRQTVSSDNLLSPMESERKSSDINESPVSRTGTLDDADVLDRPKVPRRKDSYGDMSSGRMTPMFVMESPMDIGEEGADREDAYFGPHNGESLRDGRSNVAHVEEEGDMGEEAEDWQKTKAAKRVSLVRPGEMGDWTTMRQVSAGSRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFE9</accession>
    <name>A0A1E3JFE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032675.1">
        <property type="nucleotide sequence ID" value="XM_019175572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFE9"/>
    <dbReference type="GeneID" id="30192655"/>
    <dbReference type="OrthoDB" id="2562067at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130311" evidence="3">
        <location>
            <begin position="22"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="812" mass="85730" checksum="179E705F38428DD9" modified="2017-01-18" version="1">MRLDLVNHMALSSLYIAGAFALTNPAPTVPPVDRRSHTVAFPSYTHPSSHTEHAREDTETQTLAATATTLGSEDTTASGSATTTQSYNLVTVSTPIALAATMGLIMPNPWRTLYTDLEYSFGFIDAVSQPAPTYGGWIRQVTPLMILSNHTVDVFTSSGTDDPTSVDAIPIGSDGLCGATVEKSAVAYSFKFEEPGWYMFVVNQTYMQANVTSNNQCTHPILQQDSFFATQTFSISPRPTWSQGPLAPTSAYAVWAAVTTSTPGDLPYDEQPMSKSQKLGVALGAAGGVLGVAFIVAVLWWVRNKRKMESETLAFSRLTPQAQEEFLRDNPKSFLNPNHPRYARNDAYGGAPAPPGTMAHGLWYSQQLWNHQGNPSAVRSLIPHCPSSAQLLLCSTTCLSSDTSQPHPVMRASFLVAFLALVATGAYSVPRPQLQPINETIKATECACAHPNQAVISVGTADSPADSVPTGIPISEVDCPCAYDTTSQVIDASDYSAEPAVRALDPSLAESALSDQLTSGKSTDGTSASDAAAPGAGQSADVESLKKAGLALLASKYGSMLPSATPTAAAANLGRGGALPSGQNIDMEALKKAGLALLASKYGSMLPSAALPSARNVPSAATSFAQDFVDKYNEISAGAVDVWRSENSRGYVSELADDILNKTAVTGKHVLEGASHVLNKTASLTENTVDKALSLPSEELKLLGAPSVAYPATPLQGTETDQLDSRFVDEILNEAASFTGEVVDKAASFPAEELKLLKTSERGLGVIVNVSAELRDSDGEAGDADDEEQSDDDTFNAVGQKFPIYPPPGSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFM1</accession>
    <name>A0A1E3JFM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032701.1">
        <property type="nucleotide sequence ID" value="XM_019175598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFM1"/>
    <dbReference type="GeneID" id="30192681"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="94"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="268" mass="30049" checksum="EB46903BD914BE6C" modified="2017-01-18" version="1">MPIHLHARTARAAARQSARLFSTHSSLSARAPAPSPSSTARTRPWDLGAVPKYAFDDATSLGWMRMFRIEEGEGLVKKIEQDRQVLRAANKTKFTPPTSPIRMTTTIDLSKPDSRFHTKCALTVPVSSLPLKSPEAIHRFKLLAGPRWSPGRPGREEFIQNEDTLGKEGWFKISEERFESSVQNKKSASLTLQKLVEAASDPNSPLPSDIPLDTRHLLARHQKKRSRQNVFTWASGQTFLPRQTSVGGVRGFPIEWLPENLREKALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFN1</accession>
    <name>A0A1E3JFN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032711.1">
        <property type="nucleotide sequence ID" value="XM_019175608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFN1"/>
    <dbReference type="GeneID" id="30192691"/>
    <dbReference type="OrthoDB" id="2578383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="92" mass="9655" checksum="999D9AE3E95816F2" modified="2017-01-18" version="1" fragment="single">ISLLRKPVDKAGRGDEPLVDPRPPVDPQAFLPAPSPGGRQTRCGLLKGPVAQGTRKSQTLRIRLQRVQLPRGLEAAKEGQAGRQAGAGGEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHL7</accession>
    <name>A0A1E3JHL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032663.1">
        <property type="nucleotide sequence ID" value="XM_019175560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHL7"/>
    <dbReference type="GeneID" id="30192643"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="496" mass="54637" checksum="87948CA5866EBA95" modified="2017-01-18" version="1">MSSIVESRPRGTYIPADCPSCKSQQEYMVPPTFIGTLRVRCAGCKQMFTHPQPKPSNARSSATGSSGSSAPAKSRRIGSDKNPLDMAYYNILALDSQCTTEEVKKAYRRLAIKLHPDKNRDDPDAEEKFKEISIAYQVLSDPELRHKYNEFGQKNGGGMSEPEGGFHDPEEVFGKMFGGGRFEVLIGNISIGKDMKQAFQQQEGEDAGDYTMGPNGKPVMTPEGLQKKALRDREAAEEKAKQRKARVDKLAVNLVNKLNIFTEAAKSADDKLVGSSFKEICRLEGEDLKDENYGVELLHAIGKQYQAKSAQHLASSQFAPLGWFHGAKSSIGVVSDTFATIKSAMELKAVFERLQAAEQSGIAPEELRKLEEQASEQGLRTMWKGVKLEVESVIRETCDAVLTDPNVSKEKLHLRAVALGMMGEAFDIVGKPQEDFVKIETAASKQRESAARPPPPAPPRPQTASTERKEGDASDKDETLKAAYQAYEARRKDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIC8</accession>
    <name>A0A1E3JIC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032833.1">
        <property type="nucleotide sequence ID" value="XM_019175101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIC8"/>
    <dbReference type="GeneID" id="30192175"/>
    <dbReference type="OrthoDB" id="2569417at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39803" checksum="D73D0617646E896A" modified="2017-01-18" version="1">MPLSPNAPVFVRKSHSIINNALPKPVASNPQPTPRVIHPGYVHESLDDILLLTSDNVGFYVSLAFLTRYSGFFADFESFPQSEGEKPDADKFECETREVPNATSLGLHLVLDALTEVENMALLSTLPHNPLPGFKPSSEPFVDQWPLEKVYIHLGDAVKLADAYDIPEFSAYMRIVLPPTAWHQYLMAALSENEALAKTASTQTLPYHIEDMPPEVVSILYKQAPNFLMRIRSLHKRKRKSLPGLTLAMIRATPMSDGTADFGRKCKQNGGCNSYVRYEHLAPDLRWKNFRADAGETMRDITENAKRDEGVETLMKRAINEHVDCRVCGARLLKTFDHAWQNWKTQWRPQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIK6</accession>
    <name>A0A1E3JIK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032845.1">
        <property type="nucleotide sequence ID" value="XM_019175113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIK6"/>
    <dbReference type="GeneID" id="30192188"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="579" mass="61943" checksum="D3081395A362620B" modified="2017-01-18" version="1">MSDPTPATEYPLKGPYTRETVTDNIRREQEGHGPFGTSRPHLEIEGQETVAAPHKNFHLMSLVGLAYAILNSWTAMAVSLSVALPSGGPTAVVWGIIPSFIGNLAMAASMAEICHVYPTAGGQYHWAAILSPAKMAPAISWICGWFATSGWVALAATAGSLAGQLITGVIALLHSNYESERWHIFLIYIVYTLGACFLNIFGLRLLPGINQTAIFWSLTGAVVIIIVCLATAAPNFQPGKFVFTEFINTTGWPDGVAWILGLLQSSFGLTGYDAVSHMVEEMPNPHINAPKTMILAVCIGASSSFIFLICLLFSISDVDSVNESAAGPLLESMFQATGSKAGAVCLQVFPIIAMAFTSQALMTASSRMVYAFARDGGLPFSRIFAIMNKNGVPIPAVLFTTVLVALFGCIYLGSSAALNAILSSSVVFLNISYSIPILLVLCRGRHILRPPSLPEPTWTLGPILGPICNCVGLGFTILTTVFFLFPPELPVTGLNMNYAICVFGFILIVSVITWVVDGRKNFIGPRDLGALLELARSEVDATKVNAHRADGGQIELDRRTPENVSVTHSNEKESGGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIP1</accession>
    <name>A0A1E3JIP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032887.1">
        <property type="nucleotide sequence ID" value="XM_019175155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIP1"/>
    <dbReference type="GeneID" id="30192234"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="297"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="594" mass="66308" checksum="31646185B9B13676" modified="2017-01-18" version="1">MSITQQAQDAAAKLADTVTSSLSLGGQSSTLPTLYIDEKAGSDTDGTGAELSPFATPLAAYQSLKPAPTSDANPTSVANFLVRKVDSAELSEWVEITPSAKKRFVKGIEGWRKKEAKQALEGARIEKQKQEQAEKDRLRREEAQKIVLLDDPSKESKTIKVWAAPESVGQRVRLQGWVHRFRPQKTNYFVVLRDGSGYLQCILTGDCIKTVDAIDLTSESTIEVVGQLEKVKEGQTAPGGVELSVEYWKILGRAPAGRDALESRLQPDTDASIRADLRHLELRGETASAVMRFRALLLRAFRESFNKRRITEVTPPCMVQTSVEGGSTLFAFDYYGAPAYLTQSSQLYLETVLPSLGDVYCIQESFRAEKSLTRRHLSEYTHLEAELVFIKFKDLLDHLEDLICGVVDALLADPVASEIIKSLNPDFVAPQRPFVRLDYRDAIKYLNEHGIKNEDGEDHVIGDDIAEAAERKMTDQINKPIMLIHFPKALKSFYMKTLEGAPDFTESVDVLVPGVGEVVGGSMRIADLEELMAGYKREGIPHEPYYWFTDQRKYGTTEHGGYGLGVERLLAWILKRYTVRDCSLYPRFMGRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIX5</accession>
    <name>A0A1E3JIX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033000.1">
        <property type="nucleotide sequence ID" value="XM_019175268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIX5"/>
    <dbReference type="GeneID" id="30192348"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO00808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="33769" checksum="05D0D96136DF89E9" modified="2017-01-18" version="1">MRLPQLTLPKNLVRSLATAAEQASSSTAPPAPSPPNKWSPHTLRTGLIARKRGMTAIWDADGRRHPVTILQVDSNHVLRHNPPLPQASSQFHSLQIGAGDKRAKNTTKQQLGHFRKAGVEGGKYIVKEFQVSEDAVINVGEELSAGHFVPGQYVDVQGATIGKGFQGVMKRFGFRGLKATHGTSVKHRAGGSYGQNQDPGHIIKGKKMPGHMGNVNRTTQNLLIHRVDHLLNLLYVRGSVPGHDDAFITIRDSKKLVKAKAQLALKKGKEEGEWLGQGVVGLPTPGATKAQVESEGWPEVVEWKGEGYAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKS4</accession>
    <name>A0A1E3JKS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032909.1">
        <property type="nucleotide sequence ID" value="XM_019175177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKS4"/>
    <dbReference type="GeneID" id="30192256"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="423"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="594" mass="62862" checksum="A2E00101BABA9023" modified="2017-01-18" version="1">MSSITPRKRKADSSAEKAAESSVPTPRSGRTSKRVATGASRGSSSNPVPFPTPPATRHRNANLPGQSAVPLGLPSHPDAAPLPSHLSSLLNLHRAFNLALSLHIATHHPVLPPHSSTATSVKLPNLTNYLAIKETVERTCGKRFGPAELGRLAWVWGWDGEEIMDEKAVSEKNKKAMLDEDNPFVVPASPALGAGEVSGSTYLITSTRALEQSTGRRIYTHGLGIELGLRQGETRQLLANSDGGFKNQGQGGGTAAIGRWTATGEVREHNFRAKLEKWVKLHGGYKPSEASVLPTPSTSEDSTRSSIPPIPILPLPSLPTTTFPAANLMAAFTSPSSGPTSTLTPKKNHLPPSFDSPKTAGLSDPFEIGDKEGDVKGKIVRPGSVEERRKAMMARIKAKSGGKGSLSTLGSSVGGFGRPGTTSTQQEGLKRRSILSRLEGVAESVWMMFSGPALGPSSLPTPPRGRRKAIPMAEAAEVIVKSSKTPISTAEAQTSLQMLTELCPFFLHIKTIGRQDWIEMPAAVAVPAPLSPTAATGFSASPSASTLPARQLPASPSTPGRLKGELAGPASPGKIRRQGGLREVRERIRRELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLY1</accession>
    <name>A0A1E3JLY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033120.1">
        <property type="nucleotide sequence ID" value="XM_019174741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLY1"/>
    <dbReference type="GeneID" id="30191809"/>
    <dbReference type="OrthoDB" id="10394367at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="92836" checksum="CEFA04E15B333961" modified="2017-01-18" version="1">MADVGVPLFPSLRHPQPHAEPLPRQPAPHVTPEPTTRTGLGLYRPSSFYNPHHPAPDPSNDDDEAASDTGSCRSRASAPSLLPTSRWTGSQYFRLRKDQGEDVERPRSAPGVMAVTQELFGFGETRVGSPGEEDVLMAEGLWGVGSLPDVQEQQDKYTGNISRKRSDSVPPLAGEELEWKDGTGSSSEAGLTVPLQYDSSLSSSATLLNTSMGPSPTPTFVDLINTNPNSTQDNPDSHPASDSNDKPSIKTTPNVKASKKHGRRLGAKERKKMSMRNMRERGKKLEINEEEARGGEQGRGNMVDELPSLSSDLSFPTPGSAYDSRYSSTSSDAQVVSANDTSKTFQNQTTISTAPTTIHDQATPDPEQEVDGASRQTTLEDTQVKDNSAEVDKTGQQPKTSVKKSSPAKEKKDLKREMRLAPTNTLERARINYTYNELSNTHWYYTTEQPHLKTFKTRFFARRFIPQGKIFMWERMFTCLPGDLKGLEERHAYQAIPKDLRPQFERLPDNTKGIGFWRGRLLSNSFVSEGKYGYSGRRARCVFEKMGRVPRSCQWNARVLMDPREQAGYLLALHDIPPDTEIFIRWDEYFNSEIPLDFKPYHFTCSCSICASPNKPANKHIREQRLVFIKLFNDVMVGQLQLQLGAAADPLPQLCRIEYAIEIAVKQGYRESLEMVYAAGWSLAAQCCAEDCILAWAAGVRNLSLLFMGETLGERRDIKITLERYTEGNVDEWGLLGQFKIRGPNREIVKPIFDKFSWEDYEEIRRSRSPDDPIRPVIVAVNPSTGLLPDLTLDELAAFIDGDAEKKEKEMESKAKAKVGKKKSRKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM05</accession>
    <name>A0A1E3JM05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisome targeting signal receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033153.1">
        <property type="nucleotide sequence ID" value="XM_019174774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM05"/>
    <dbReference type="GeneID" id="30191843"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="637"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="78012" checksum="97299AFEFD03D55D" modified="2017-01-18" version="1">MQGLLGGAECGTSSNPLKQVAQREGIDNSLFKDRFAQSPSSTPNAFRPAPGPSQQQPTSIPTHGPNLHANATPHPFNLSHLSAALSQSRSGSSSPQSHAQAQAQAQAQAQAQVGFAQGWERYQMNGARSPLAQQPQYHPNGNGGGWANGFQEFQSSGKGKQRAEPLPQPQAYAPVEAQQGYQPHQPYQGYQSGLSMGGGMGMGMGMGMHMGHQPFTPMYQNHLSHPPSQLPTNGHGSAGAEQLDQKQMEDLFSQAESDWKASSAPAQSQETNLDAQAEEAHEGDEEGKEKERGEGVEEEKEAKGDFEKVWESLKPEAERLNELAQWENDFSQQFTNDEDDLFDILNESLNRPDVGQMGLDQQWEGLEQSGAEALGRGFEVRSDGLPAQTQTPEALKSMSASYIWAEANKLLASGSLSASANHIEAFIQQSSAAERQQMEVSLTEAWALLGRVHAMDEKEEKALGAFQKGREVLGQEGAAGKEGIAGEMLTNLTISYVNESLDLAALTTLHTFLTLLHPSHAGPAPSTSSPLLDPSSASSASPWALHSQVSDSFLSLARDQYSHGGVVDPNVQVGLGTLYYMMGEYDQARDCWVSALKERPDDYLLWNRLGATLSNGGSSEEAVDAYRRALELKPGFTRAVSNLGVACLNIGVHREAAEHFLAALSLHPSQQEGMNPQQISNDSAALWGTLRKALVAMDLPDLARKARPGTDLEEFRRAGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM48</accession>
    <name>A0A1E3JM48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033201.1">
        <property type="nucleotide sequence ID" value="XM_019174822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM48"/>
    <dbReference type="GeneID" id="30191893"/>
    <dbReference type="OrthoDB" id="2574664at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="397" mass="44027" checksum="267A671EBA17AB48" modified="2017-01-18" version="1">MIALPQRAKRPRSPSPTFEPDIASPLDVLLKRRRRDTHQQQPFGFPETPHSTQSPVHGYEPDYFQQGGNGVPHTPGSGESPHGVYGQQHAFNNAHAESSSAAQLRAAGLNQAGVGIGVERRRTKQWNRINAPMPLQQHQATQQPVNALTTPTTHAGVYQTQPTSAFPFPTPPPPPRVVSTRAAPLMSSSPIRNQPPSSSPFRDRPSNDDLVAPEEMCEPMDEEEMVRNWGEAYAEQNSILHSLHMTRMKFPPHASPQSHPSYSSHSSSNPWRTPMASSSTLFSPGPSRFAQEAAGQVSPHPYRTPYQSSPFTPARPSGNHVSYMYPTSSNQPPSDIPSSSERHRFRGEDDDMGEMEAEAEIVVESDAEREVANRYEEANKLLGELAMVRRQRWGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR22</accession>
    <name>A0A1E3JR22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033379.1">
        <property type="nucleotide sequence ID" value="XM_019174327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR22"/>
    <dbReference type="GeneID" id="30191386"/>
    <dbReference type="OrthoDB" id="2574776at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="398" mass="44151" checksum="E3E395E7187435DF" modified="2017-01-18" version="1">MTRIYFSGEARPSRVQRDQRHQTGRVIDKSLQSLLDLSSRSSVFYNGPLKVSGGRITPGDDGKRVAPDMSIHDWCTSTNGLSGLDKPLTAFNNVASFIQDRYRRTDGSRVLDRDDANQLAPFILQDKRNDGTKEGRDFVALGLDDMVINDVLPTKEEFSSSQEQVQVHAFDIPTNEEAASRIDVSDWEGNSLDEWLTERVKHEHSGDWRATDGYVLSAGEEMLADVRSLGDQMSRRHDLDPDLTTYFSTRISTYMVDQMLLSGEREVTPEFLHDADFNLFKAKNALMSMSPGERKAILYGRHASAQSSAATDSRPSWRSSSLPQDSLPSSFGSRGFHRELASDGSKPNSASGGPQPSRKTVESTEDDVSVPSDATDTRASQAKGVRFNPIVNSVNYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR46</accession>
    <name>A0A1E3JR46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033391.1">
        <property type="nucleotide sequence ID" value="XM_019174339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR46"/>
    <dbReference type="GeneID" id="30191398"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="568" mass="61904" checksum="CA04AA86CEE01E54" modified="2017-01-18" version="1">MPEEDSGGVQMAKPSSLRGRSDILTNNTSSERVEAPVTLKAYLLCVFASFGGIFFGFDSGYMNGVLGMDYFINMMTGLPIPGPDASASEVAAFTLPAWKKSLITSILSAGTFFGAIIAGDLAEFFGRRITIVAGCGVFIVGCVLQTASTSLGLLVAGRLISGFGVGFISAIIILYMSEIAPRKVRGAIVSGYQFCITIGLLLASCVCYATQNRTDSGSYRIPIAIQFAWALILGTGLMLLPESPRWYVRKGRVEEATKALSRVRGQPVESDYIRDEITEIVANHEYETELIPNQTYLGSWAACFSGGIRNPQSNLRRTILGITLQMMQQWTGVNFIFYFGTTFFTDLGTISNPFLISLITTLVNVCSTPISFYTIERFGRRPLLIWGALGMLICEFIVGIIGVAKPGDSTVVKAQISFICIYISLFASTWGPGAWVCIGEIFPIPIRSRGVGLSTASNWFWNCIIAVITPYMVSTDQGNLGSKVFFIWGSTCVICFVYAYFFVWETKGLTLEQVDRMMEECGTPRRSPGWKPHTTFAAEILGAHEHGGLEKTGSVEQHEKAPAPAHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR77</accession>
    <name>A0A1E3JR77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette, subfamily B (MDR/TAP), member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033406.1">
        <property type="nucleotide sequence ID" value="XM_019174354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR77"/>
    <dbReference type="GeneID" id="30191414"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000085">
        <property type="entry name" value="Probable ATP-binding cassette (ABC) transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="150"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="467"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="736" mass="79188" checksum="A0CB4EF162FFAA3E" modified="2017-01-18" version="1">MLAPMGLHAHLRQQLFKSRLRPVVQGGVRVPSLPLGPLQCRIAPRCLHTAAPPRLPRPTLRSQGFRYLTGDSSQPPASPTPSSSTTKVSPSQTPETTASEVKPPRPSILARLTSNVSLTPEEGESGKDTGNSNIRKLMSLAKPEQKDLTIAIGLLLVSSAVSMLVPLTIGKLIDFFSTHASTFLGLSFPVAAGILAVTFCVGAAANAGRAIIMRTSGQRIIARIRNQAYFATLRQEPEFADRSAGDIVSRLSVDTNILGDSVTSNLSDGLRALVSATAGVAAMFWISAKLTFVMLCVVPPVSLGAVFYGRYLRKLSNKTQEAVGDMSKIAEEKLNAFKTVAAYNSQSLEANLFAGKVDSIFQLAKKEAYMTGIFWGLTGLTGNLAMLCLLGYGGHLVSIAEITVGDLTSLLMYSAYVGGSVSGLTGFFTGLMRGVGAGGRVFWLLDRQSRIPLDVGTRLPLTRNGPIVFENVKFRYPSRKEVQVLKGIDMTVEPGTSVALVGSSGSGKSSVQALISRFYDPEEGRITFDGTDIKEFTPESWRSRIGVVFQDPILFAGTVHENIAYGSPDISREDVEEAARAANCDFIWSLPDGFDTMIGKGSLSGGQRQRISIARALVRNPSILLLDEATSALDSASENAVNAAIDDIIRHRNITVILAAHRLSSIARAEKIVVLENGVVSETGRYDVLSRKEGSRFRTLMAAQLLVEKNSEAIPEQEESAEKSQLEEALVVEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRK7</accession>
    <name>A0A1E3JRK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033569.1">
        <property type="nucleotide sequence ID" value="XM_019174517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRK7"/>
    <dbReference type="GeneID" id="30191579"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="69" mass="8003" checksum="395E6C6CEEBD2112" modified="2017-01-18" version="1">MIIPVRCFSCGKVIGNLWDSYLELLAAGVDEGEAMDKLQLKRYCCRRMVLTHVDLIEKLLMYNPLARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRT0</accession>
    <name>A0A1E3JRT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033632.1">
        <property type="nucleotide sequence ID" value="XM_019174580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRT0"/>
    <dbReference type="GeneID" id="30191642"/>
    <dbReference type="OrthoDB" id="2506317at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="172" mass="18936" checksum="35E86162EC7E2537" modified="2017-01-18" version="1">MLSTSNIGPISQQYSAAATVPLIKSPSLWLPKPVELPTDVHPLPEDITAYFVYPFTLEEHVRQQHPSPHEAIAQRRARLAEVLHQREEEEERKEKDELRRIAPGYNPSSLLVPTSTNHTPSTSISQSHGGQPALSSLSRDVTGSEGGEAREGAGGDPMDDLVARLEEMEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTW6</accession>
    <name>A0A1E3JTW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033618.1">
        <property type="nucleotide sequence ID" value="XM_019174566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTW6"/>
    <dbReference type="GeneID" id="30191628"/>
    <dbReference type="OrthoDB" id="10510380at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="17619" checksum="B498A2C3E35BE2E6" modified="2017-01-18" version="1">MPNIPTTLSMTSSLGAAPRALSNIPSLGELQKQAESLGSSISSNLPSLPAYSSPPESPQRLGQVANTGRPNVGKFPGAPPSYSEADPRVMPGRQEGGNKLKKAFPGWIRLPQVGIPGEMVVRKDLTEGGRGRPVMKETRVYAESVRSSNSVSQNNRPPQPSFLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU70</accession>
    <name>A0A1E3JU70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033523.1">
        <property type="nucleotide sequence ID" value="XM_019174471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU70"/>
    <dbReference type="GeneID" id="30191532"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="42666" checksum="9651DB537B623474" modified="2017-01-18" version="1">MGFFSFFSKSSPPDYETVLSKLASDVTEAKTNLSAIRLRERRTALLVNLYGVSFWAIWAGLWWVRSLPLGLIKTNYEELLGRIVGLAGIVGTPFLIWVLNFVVHAYFSRQRVHEETHLRKLLNQQRKQVDEIKKATNYDSTRKLIERYDEANGLGSPIGPKTPQRPGQVTPQHVTPSSKGPSGTPRAPGHLVGAGGTPGPAQPQTPLPVPQGLSLEQATAFHLQAGAIQPILPTPEKKWYDRVVDSILGDDPSQGNQHKYALVCEECFRHNGLVGSKYEWERMQWLCPRCNHLNPSPLSRLPPDPNQPLLATPTQPSKFQTQAQTQAPSTPSHAQRSSAASPRGRRQMGDKGSPKSSRLAQEVFNADDEEGDEGRSEEGMEVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW55</accession>
    <name>A0A1E3JW55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xeroderma pigmentosum group C-complementing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033743.1">
        <property type="nucleotide sequence ID" value="XM_019173936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW55"/>
    <dbReference type="GeneID" id="30190988"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="580"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="702"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="857"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="766"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO05088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117081" checksum="3DE235CDE7CCF66B" modified="2017-01-18" version="1">MSASRPKRKMIIPRPRGIQAIAATLPHGSPAAAQSGKATPAASAGSSRSTPRPATSNKGRGEKEVQGKGKSIGSTAVSPISITSTVQVISSDDDEEEEGLEEVPIPTAPSSPYQNTPISQPTGTPTPLVGEHAAEDEDDEDEEEDDGVIHLEIGGETAEEKAKRIALMNRKKPMTARDRALRLEVHKVHVIALLASSSQRNKWCNDTLLKARLLSLLPHPLQAAFNIPPSRFPDRAQRSRLFFDALQTLVTWWSQTFFDISDYTLGIRTRPWDDVQEIIESIPKEQLRTLPKYEEEKSGKKGKAREENPVLETLEQECGGERLRSINSLMKKALQQEGSRDVSAQLFVSLARAAGLGARLVTSLQAVPWKAEKAGTKKKKPQGAGKGGRTVASRQGMGDDEDDEDEDEMEEVPIPGVSDGEKKSNTRGAGKRRLKDPADLYRLRKYRPPPQKVGSKRKVKQDLSDQPPVFWAEIFSRSDQRWIPVDPVRGVIRKKQHYEPTSDSGPVRMLYVVAFEEDGYARDVTLRYTRNFYAKTSKLRPPTRSDEADWWSQSVMGFLRRPYRLNRDDLEDAELEMSQESEKMPQHMSGFKDHPIYVLKRHLRQTQVLPANTNPIGHFKGEPVFRRSSVLEVKTPENWLRSGRITKPNQDPLKWIKQRAVTLEKRRRMELAKEQGEEMEQGLYAEWQTEVYVPPAIVDGVIPRNAFGNIDLYAPTMLPVGAVHLPYKGIAKVAKSLNISYAEAVTGFEFKKQRAVPTLSGIVVAAENKQLVLEAYEESTAAAEERERVKREEKALKRWVKLVNGLRVRLRLREEYGGTGDTANPLGEAPDPEDTNNLPRKPGGKTAKDVLAAAHKMGTEAWEDSVGREEEDAVDEGMEEVGVPEPALPKDEVKLEREEEKEKEEVGVEAQASTKPKVMLRFNNPRSNASSPALPFHTSPAPSKRATRQRQPPRQSTRAAGKRKARTPSEEKEEETSEDEILEIPKTSRGKGKSTKAEPTPHVDGGRRSLRSRGGKTKEQEEEERLKNERMRLALASDDDASEEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT2</accession>
    <name>A0A1E3JWT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033970.1">
        <property type="nucleotide sequence ID" value="XM_019174163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT2"/>
    <dbReference type="GeneID" id="30191220"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="11">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="194"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="681"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="847" mass="97620" checksum="4414DF3FB2519872" modified="2017-01-18" version="1">MTPSTIPLQKWRFRQKPKTPDPDNRWTSCWIPTSVQAELIKTGDIKDPRKDLNEWDAQWIGEADWKFRCDFDIPADRLKAAHCDLVFEGLDTYCDVLLNDRKILSSDNMFVAHRVNCKEHIRSGNNRLLIVFKSPWQEAKQAERAHGGPRGAWNGDPCRLYSRKAQYGWGWDWGPKLLTVGPWRPITLEIYDYRIEAVRIEAHISSPDLKTATLRATVDAVRANGMQLRFLLFDQSGVCLKEEMQPTEDSWVEWTFEDGQIHPWWPRGYGAQELYQLRVELWKDVAEAAAHKSIRLGFRHIEVVERPFIHQRGTSFFFRVNGVPIFCGGSNWIPADIFATDISPKRYRQWVEKMVQGNQNMLRIWGGGMYEHDELYNACDELGVLVWQDFMFACGIYPSYAEFNNSVKNEAEQAVKRLRDHPSVVIFAGNNEDYQVAESLKIVDYTDESGDYMHSEFPGRHIYEIILPEVVHCLSDIHYHRSSPYGGKTSRDPAVGDIHQWNVWHGTQEPWSKWGELSGRFVSEFGMEAYPNLKTVQTWSDNQAELFPQSRVSSQHNKAIGAERRLESYIMENFRHAYDMPSYIYYSQIMQAECLAAAYRAWRRNWRGEGKEFTAGALVWQLNDCWPCTSWSIIDYYMRPKPAYFTIKRELATYTVGISRKEVKKPKDKTTDAAFDIFESAIWGCNSSLSLKPVTIVVETWHLHRGILDRKFIETTLKANASTEIWSGPIPRQPVRSSLAQPPEPIIVSARLLARESELVLARHSSWPDPYKYLRFPEPGLKCQVSEGAVRLSCERPIKGIVLDVEGDEVEWDDQGIDLIPGDDQVIAVKGLEKRAVTARYLGSDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT5</accession>
    <name>A0A1E3JWT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033979.1">
        <property type="nucleotide sequence ID" value="XM_019174172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT5"/>
    <dbReference type="GeneID" id="30191230"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="532"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="68364" checksum="FBA2D464AF65BC2B" modified="2017-01-18" version="1">MSLSADLTTQEKLLLSQAIYKLGAFSWPQVSDLLLVHPSIKPRPKELFTPDRCEAMYKEMMGVIGINVPTPDGMKPHTKSHLRLAQTHYIARMSELHAQIAAHESRFTALVTEVTSLKSGDLDDALKREIVEGLEKKFGKKIMDGWLEGEGKGQILKAVEAGEVKAGEVDPEEEKKRKEKEAEKAKVAAAKAKEAEEAAKAQAEAEAAEEAEKAKAAEQAAKEEAAKAEAAKAAEAVQDASEDVEMKEATLETPPKDATPEKEAVKTPEPTEDISPAQSPLSPAPSDLSPIKPEPAPKRSHKRKAASQPRGAPAGKRSGRRGAAAAAEAEESEGEEEEHSDEEGDNEEEQPATRGRQGKRSSPAKPSLSPTKEGSPANSRRAPSVSSTNSATPGEERRSTRRGAASRRGKREVSKPVRDQTVEREEEDNTSVAGEDHEEPRKATRASRRKSGAVEAATPTPSATERRGTRSTAVVPPRLGHREVAASELSVAGGQDEVAVKEEAAGFSTTLAPRVAKRSSKPFLMALFEIILSHKFSNVFETPVRKSEAADYYDVIKKPMDLKTVKAGIKNGRIGSIDELERDVLLIFSNAMMYNAPDSQVYGMAKDMMKDCEGHFVHYRNMEMEMGGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX61</accession>
    <name>A0A1E3JX61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034066.1">
        <property type="nucleotide sequence ID" value="XM_019174259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX61"/>
    <dbReference type="GeneID" id="30191317"/>
    <dbReference type="OrthoDB" id="2578400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15544" checksum="4C5A032AC30C790E" modified="2017-01-18" version="1">MGFHSLQYLPDDVVVSVAFNIEVSSDSHTAHCHILLARKSKSKASSKAHDCRSVGFKSGKRLKLDASPRETLAQLAKMSHRELLVSSILESLEAQSKTKDLNAKIEALTNYVAIPLTQEIKPEVLSIVKWAYMSASSSYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXZ4</accession>
    <name>A0A1E3JXZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033722.1">
        <property type="nucleotide sequence ID" value="XM_019173915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXZ4"/>
    <dbReference type="GeneID" id="30190967"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="541" mass="59685" checksum="9218838EB0A34F6D" modified="2017-01-18" version="1">MLRLLPPRAAARVPAAARAYATAPRQDLPPKRPRFQPPRTRSSTNRKPRLPWVLKTLTEYKAENRVPSPLAYINIIEAASEFACSHSVDGGHSEGIGFQVAMAAWEDARRGGIELGQKGLDAMMGFAAVYPHLLPSLLLYNQDRQTPTYNAIARVAQTNYELEEIVRVVDEMFKQGLSPNSATIRHTVRLACEWGHPRLGLQIAQKAESESTFGFRLDPQSWVHILIASADNHYLHGIETAWERVRTSYTPDEGLIISILNTAGRWGRPDISSDFLGLLPGPPQEHHLAPLLEAFCNAGEVPNAFQVLSTIRDAGLAPSLATAQPIVAVLQNTEVIDQAFYTLEDMHSAGQAIDVVALNAIIEASVKVGDLQRARATQMAAGDLAVSCNIDSFNLVLQGCVDSKLRTLGDTLLSEMTVDGITPNATTYELVIELCATQPSYEDAFYYLEKMKGEGFKPSSSIYEVLVRKCVKMNDRRWSMVVDEMRAVGHKVDTSLLAFINSGGSDDRKRDPARERRAKDQFTGSKRRSWQTSGADKSKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYQ6</accession>
    <name>A0A1E3JYQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034134.1">
        <property type="nucleotide sequence ID" value="XM_019173429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYQ6"/>
    <dbReference type="GeneID" id="30190476"/>
    <dbReference type="OrthoDB" id="10630524at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="477" mass="54082" checksum="A8A3BBCD7C70E460" modified="2017-01-18" version="1">MQCLEHPHKHCRPWSTDLPSFSSTAVYSAASGFAHKNFPLECEDLWSTRTSILPPYPDITPSSSILAVACVTYEAIVCWAEDNVQDYRYDVEDIVTLARDGFHTLGMSEGTSTRGWTTLRQALKEVPQDIQNEVKSQMRPMGTGPLTMKSKVFNASMAASIREEWSTWGKELWERWWEEARTLGEKDIRALFSSRPEEHAKMEKSARRAGYDRACNVWKTNLREDCPWDNMADDDAMSMIEREIGEGNDDRKDQVIHFVGFGAIFDCEGGARQLHWKRRLGECGFRGTVYLHEKKCHRGVGFILLGQSVTGRTLRHEETRHCGVGFILLSETFIWGPKYRRRISEFDKVDDSILQIVVSPILRSIIDIASSAASAICQGQSSRRWSIKASHLVGRRMGRSKAKLRKTTVVPSIHPLATVFQDRPTPPRVSALLQKSSCTLRVHSPHAPIRHPDHLTFSRFEMAPITTCMMLFAGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZC9</accession>
    <name>A0A1E3JZC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L198_01357</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 24">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034225.1">
        <property type="nucleotide sequence ID" value="XM_019173520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190570"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1215"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1613"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1640"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1668"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="9"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="974"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1902"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODO06125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1974" mass="221663" checksum="D44A17FBF412100A" modified="2017-01-18" version="1">MAAPASRFQGVTDLASSLAVTEDTTVVTLQERYLAHKTYTALSSSALVFTNPYNYLPSDGDDSLLRYVQEYYRVAKEDDTGRNEEGAWRKGGLDPHVFQLALNAFFNMKRTGQDQVIITNGPMGSGKSELKRLAIEAISEVSVATPGKKGSKLGLQVASAEFIQKCFGNAHTLSNDDASRYGSYTELQFNERGRLDGLKTIQYYFERSRVSQAPVNGERNFHVFYYLVAGAPAEERAFFKLGDMIDYRYLNCRVRRIGVEDKHRYSQLRQAFKAVGMSSRLVAQVFQLLAAVLHIGNLQFTPGDGEQEGAQVVNADTLDVVAEFLGVSSESLAEVFSIKTVIIRKEVCTTFLGPEQAEQVRDELARTLYSLLFSWLIEHINSKLCKDSFGSFIALLDLPGIQRGSSVISTNSLDQLCLNFASEKLHNWVLHRVHQTAKQEAEAERLIFNKVPYFDNSDCLEMLSASRGGLVSTLDDLSLKKKAEQNLLDNLTKKYHSHPSLSISSSHGYRSASSFTINHYDGPVTYETSNLLERNAKETSTDIVQLLRGSTSTQFPEMESRGSSNPFIKGLFTMKGISMQTHPKSDSTIVAVQQSVRPVRAPSTRRKQRRSLVPVNEEDEDAEDFGVGGGNDESYSSKDLTCIAGQHFHAVEALLKSFDQTQMWYIFCLRPNDSQLPSQFDLRAVKSQIRSFGLVELAQRLQGNGWEVRMSLEEACERYKVELARRGIMEGPAWVERLRDFKRLLKASDAEIGIGQQRVFLSHSVFRYLEDKLRARDNEEHLHQYDDAAFEGQKRIQTDPFSPHRHHNSAESRQLYDTSFPDESSAALPLVAHAQPNPMESTLDLDDMPPTSVPYGTHYGDASTTDVGEYASSKSAYASSLHKSEKDPLDEDNTPGHTQETYKESIVRRRWVWMCAALTWWVPGFMLSKFGGMKRSDIRQAWREKLAINMIIWFICGCTVFVIAILGPLICPTQHVYSTSELASQSYTSHPDEAYTAIRGEVFDLSSFAPTHLTAVSVVPKRSFMTYGGLDATDLFPVQVSALCDGVSGSISDYVTMDTSNTTDNYAQYHDFRASTNDSRPDWYAEMMIMMRHRFRKGFMGYTKKAIKTQASQGSAVGIVDDVVYDLSDYIAQNGGGLKLPDGYTATSQDQSDRQFMSSQVVDLFKYNSGKDVTKLLNNLAGTLGQDVVDRQKVCLRNLFIIGKVDSRDSAACQFSTYILLVLSIIMVTIIGFKFLAALHFGSARAPEAHDKFIICQVPCYTEGEDSLRRTIDSLCKLRYDDKRKLIMVICDGNIKGYGNDKPTPAIVLDILGVDPNAEAEPLSFQSLGEGAKQHNQGKVYAGLYEHAGHVVPYLVVVKVGKPNERQRPGNRGKRDSQMVVMHFLNKVHFNSPMNPLELEMYHQIKNVIGVNPSFYEYIFMVDADTTVEELSLNRLVSAMMHDKKIIGVCGETSITNAKQSIVTMAQVYEYFISHHLAKAFESLFGSITCLPGCFSMYRLRSPDTNKPLFISNAVIEDYSENRVDTLHMKNLLHLGEDRYLTTLVLKHFVNYKTKFVRDAHAQTVAPDSGKVLLSQRRRWINSTVHNLAELVFLDELCGFCCFSMRFVVLIDLVSTIIAPVTVAYIGYLIYLIVHDGETIPTLSIIMLAAIYGLQALIFIFRMRWDMIAWMFFYILAIPVFSFFLPLYSFWKMDDFSWGSTRLVVGDGGKKIVIHDEGKFDPSLIPLKSWEEYENELWDHESSQSEEFLAPVKSEYDYRPRSTFSYGYDQPQGMQSRSFTPVSSVYGMNHPSANANPFGATDYRSIQMNLAHRPLLREESFDRMSQFDGGSLYGGQQAHNPFAGGFAGQRNQSYTSLDQAAYQAPYQAPPSQRGYNPSLHTAEASTMEDSFAAPVDYLGAMAITDSQLEASIRKICKNADLDNLTKKGVRKALEKEYGCGLDERKEAINRLVEKVLTGTFCGAWDDPELTCLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG0</accession>
    <name>A0A1E3JZG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034276.1">
        <property type="nucleotide sequence ID" value="XM_019173571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG0"/>
    <dbReference type="GeneID" id="30190621"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29332" checksum="B385186069139783" modified="2017-01-18" version="1">MAPALPSSYIDAYNPTGLRQYPRRDVAEVLTPNSTQRVTLIVGACYIVAIAILPVLEKLIYPFKLLTVGMHEMSHALAGVLTCATVEKITLDPQEGGSTRMRGGIPAITLPAGYLGSSFMGACLVACGFDTNASKVACLILAFIWILTLWWAKSSWVAWATIALMVGLVLVCWLVADSVALRFLILFIGTMSCFYAIWDIIDDTLARKVNTSDASEFAKMIGCCGSRFWGAYWLLVACCFFAAGVLVGIAAFKDDWDTQASKARNFLGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZK2</accession>
    <name>A0A1E3JZK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034316.1">
        <property type="nucleotide sequence ID" value="XM_019173611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZK2"/>
    <dbReference type="GeneID" id="30190661"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="742" mass="82447" checksum="9493AF11EA68A1AC" modified="2017-01-18" version="1">MPPRKKPSRVSLPDPPSPSPSVPGDVPTPSTEPATPTTQGLRQRKKGDDKSGRGDKHHTEFNVKLKKNDDGKYHLLAPGTPFNEIDLSEYSFFARHPELEARAKTWKAWIFGRKFFFPVGILLGVLIAVWAMDFSSLPADMKDVWTAFPTTLDPRDLLSNLTMVETARKAIESRDFAIGQEMSEKYGIEKQHPIILIPGIISTGLESWGTETVARPFFRKRLWASRESGTATMIRAVLQNKERWIQALSVDAETGLDPPGFKLRAAQGLDAASEFIQGYWIWQKIVENLATVGYDTNSMDMAAYDWRLAYYNLEIRDAYFSKLKSKVEMMHKHNKAKVVLCSHSATFKTSTSTYTDLTSLKWVEADPDEYGFGGGGGPTWVEDHIEGWINAAGTLLGVPKAMTAFLSGEMRDTVELHPAGSWVLEKFFSRRDRAKLFRRMPGSASMWLKGGSRVWGTEEYAADDPEDATDSHGRFLSFRHPDVPPHDSALVKSTVSPNLTISEAGPYILTHTPPSFQRMMELNYSQGYESDPAILKKNGADHRKWTNPLEVELPNAPSMKIYCLYGHGKETERSYWYMQGEYEEDESRSDAEGSQAFCDASSPGCDNSTVLRAPLDFPLARKHWIDSAVTVKGSSPEVRSGVKFGDGDGTIPVISLGSMCVKGWNGTTPWNPAGIKVVTQEYLHSPDSIDLRGGAQTADHVDILGASPLNAAILQIAGGRGDLVKQKIGSKIFDYTAKMFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL8</accession>
    <name>A0A1E3JZL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034438.1">
        <property type="nucleotide sequence ID" value="XM_019173733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL8"/>
    <dbReference type="GeneID" id="30190783"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25328" checksum="7301FD15BA016A21" modified="2017-01-18" version="1">MSCCSDLPPVQAEYTPKGTYTTFSGLKTYVVGPEDAKAAVLYTYDVFGFSPQILQGADLIASQGYRVVMPDFLVGKYATAELFGPGAEAKRNEYFSQFPGAIPTQSKPLADSIAALKAAYSRVAILGACWGYKAAVVTEGLAGVDVFLAVHPTFPAPEDAEKINVPALIISTSGEDKSVIDAIEKGVEAKNPGKNVFKHYADQVHGFAAARADLSGGATLAAYVEAYQLFVKFLKEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2L3</accession>
    <name>A0A1E3K2L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034736.1">
        <property type="nucleotide sequence ID" value="XM_019173010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2L3"/>
    <dbReference type="GeneID" id="30190051"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000022">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.5, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="534"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="730"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1021" mass="115523" checksum="0A8E96579B4A7A2D" modified="2017-01-18" version="1">MTVEQQESVIPLDQMPPEERQAAERPPDLPTTIVVAPSTPVSAPSPAPLTYTSPAGVVLTFQNAGHHLSRWFQASGHTPTYNMEDVLSPGVTEAPISKKAAKKARLGEADEPAAAPTGPPLGSMRVCTVDLPYAGSVRSGLWPNKSLAKQHASFEACKVLMDKGEVDTSFQPTPSHPRGKTFEERLETKSRCNYRWESRKLAIQDQLPQGTGQGDYEYKTTPEFWGTCPPFQPDHLWASVFQLSPDGEGNYDNHPECRMMCLITSRPLPFWSSVGETVVRMGVGEQPTLQASMRLINGGKMEPFQSGTLEQAQVFTEKLMRAQIQKPLMADLAHVKWLLVPLRRSFKAPTKEIVSQNKGIKLRLKDIAWKEVDAVTDGPLTMPFTHNDMDILQRQCKDRMSTVPSEMVRRNYIVRIRTDLNPFSPHPDHPEETILQTLEKEPTTLPELSDPSQPILEVEPAALPKTGSYITYLSIPDEKRPKLYLIPEFEHWHCIPSSVHRTTSTMPFFIHQLESMLVAWEASEKLFGSVVRPEYALQALTAPTGMNVNSWTYERLEILGDTLLKFFATLHFYLAGGGANSQDDPLKTWQDRHKVVSNKTLAHNCIKLGLVNYVRDRRVKVKEWAPRDWDFDTWKGGTAMKKHLKTSADESEFRNLGDKLLADVVEAMIGASYLPNKDMDNVITTLHNLTVPLTLFKSWGDVKHVLQREHEEEEAKDPDLPAYMNFFAKTKMQYEVFGYTFKRRKTFEDVFSLSSKRETRMKRERYKMLGNAVLDVYIIDYLYETHPTEGPGSLSNMKASLRCALAVELGLQDLVIDGDDKTRRELGRATYFMNEARKKADAGLSEEEQGEVHYWEEVTVNHVTGSIMEILLGAILDDSDFDLEPTRKIFFEKILPFIEKYCKGPANNDMHPKGQITRWMQAKGCMLYSLDVEGPRLNIGTFKVHDKEIARESAFTTHLAVRNVCNAAIRKLKDEGGLEVLCDCASFKKVVPDDKIEEIFGKSRRERMLEAQEKDAASRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2P0</accession>
    <name>A0A1E3K2P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034877.1">
        <property type="nucleotide sequence ID" value="XM_019173151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2P0"/>
    <dbReference type="GeneID" id="30190192"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="404" mass="44020" checksum="2A76501EAF10688D" modified="2017-01-18" version="1">MTSTTTSTPPGPLASKSSKLIIVGGGGTMGSSTALHLARRGYTDITIMDIASADDVDGFAGCTAMCWDAWTTDPLFKPFAHEVGKVFSLSKGRMRSLNTKNKYKRMSDLGREDIKRLDNVDEVRKAAPHLAKADIAAFTCTRGGWVAAPDALDAVGRELQKVGVKAIFGSSGTFDSLTLGNDDETVKGVRAKDGSVVEADLVVVATGAWTPALIDLEGQCVSKCWCFAHIQLTPEEAAELKVIPTVYSSVYGFFFEPRPDNHLLKLVNEFPGYTNFQSCQPFGSSTVQRISVPRSHADHPDDTMPQPCLEEIERLVQKTLPHLWLICEHPKWKGVVVAPGDSGRTFNMLPVVGGQIADLIEDKLSDERRHAWRWRPGAGDPKGKGRPGPRALNLSEVETTWQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2T2</accession>
    <name>A0A1E3K2T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034961.1">
        <property type="nucleotide sequence ID" value="XM_019173235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2T2"/>
    <dbReference type="GeneID" id="30190276"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="42776" checksum="60853A1A2297EEE7" modified="2017-01-18" version="1">MDIDEEAAMNAGPSTTPTTAGDKSAAGLSKKAQKRAAKQAKMETLKPLKRAAEKERRRVRNAELHEGYAAGTLSEADKAIVERRRQIERERKEAKKRLDKGEQGDDWKGGVVVDLGFDELMADQEIASTAQQLGYLYSANRTAQHPFRTVIHTTFSPTASPRLWARMGSSNWDKWTRCHWWNEGLDVLQGQLQGSEAQEGQTQETSLGAGGEAEGNTMLEKTMLSRLTGPNLPPDLIPGKHTLVYLSADAEEEITTLSEDEVYIIGGIVDRNRYKNLCQDKAEKLGIRTARLPIGSYIANLPTRKVLTVNQVFDILVQYLKFKDWAVAFEAVIPTRKYAATGGRTKRRRARLSKHAGEEGGDAEGGEDDEEGSETDEEPDGEAADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Z4</accession>
    <name>A0A1E3K2Z4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA exonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035035.1">
        <property type="nucleotide sequence ID" value="XM_019173309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Z4"/>
    <dbReference type="GeneID" id="30190350"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="357"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="56899" checksum="FFAAC81A27E84141" modified="2017-01-18" version="1">MFSNLGLFETAKCPDPKCARARCFFAHGQAHAVSPVAGPSVWSEAKDGCGDSGRWSGGEETGRAKLEARSTGVYIFDDSAKASTFHVLNTLKSFFLCRLWTSAQSTTKYQSNPSASHRSPESPIVATLFTQFSKLYGPIIHLGPSLAHDTTLSQENEISASSSSLRTYKTAIHHAAVSISRRPPPTSLSHPSVGTVKESREKGEKAEKEKSERLERRRVERYFLKKEDFAKWRYPLPDDPELVGEGTGSKPSGEGETHNCDRCKISFTVSSQNLAARFGECRYHYGRTAPERVEGRRKWIYFCCGKERGEGGCEDGVHVFKEEDDQALARREGFKSVRTCAEESKRDGKSIVGDGFGVVAMDCEMISTTAGLSLGRVTIVDENGDILLDELVRQNRDVNTRFSGISPGQLDSALMDLPAVRSAACMFIGPETVIVGHGLENDLRALRLLHDKIIDTAIVFPHDKGPPFRRALRDIVKEKLGYFIQDRTSDLGHSSAEDAKATLDALKWKVRDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K314</accession>
    <name>A0A1E3K314_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034896.1">
        <property type="nucleotide sequence ID" value="XM_019173170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K314"/>
    <dbReference type="GeneID" id="30190211"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13114" checksum="24D5E99AD43FF589" modified="2017-01-18" version="1">MVSTPQPGHSNAHHPQSSKPVSLLSGVTILGGITAYARFSSVPSLVGSLGIGSIMALSGMRIRDGMDYGLETATASSAALMYPTIRRAVKTKAPVPATIAIMATASAAYYLRETIELHAHKPAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K325</accession>
    <name>A0A1E3K325_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">60S ribosomal protein L37-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034903.1">
        <property type="nucleotide sequence ID" value="XM_019173177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K325"/>
    <dbReference type="GeneID" id="30190218"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11849" checksum="1C3E8D9BBC936CDD" modified="2017-01-18" version="1">MKHGKILRWPFGRCLRNRWAVAGETEKPAWVWIMGMTWKLTSTFCLACAQCGYPAAKLRSFNWGQKAKRRKTTGTGRMSHLKDVNRRFKNGFREGGAATKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5V3</accession>
    <name>A0A1E3K5V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall surface anchor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035326.1">
        <property type="nucleotide sequence ID" value="XM_019172384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5V3"/>
    <dbReference type="GeneID" id="30189414"/>
    <dbReference type="OrthoDB" id="2576623at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130785" description="Cell wall surface anchor protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1265" mass="126933" checksum="3EAFAC095A2F73AB" modified="2017-01-18" version="1">MFRLLFQPFSAFFILLATPLALAQSSGTITVSSPSTCIILAQVASLETPNVITAMVPVCAASGSVSVDWPISSSGDAASSSMGIYAQTASASGGLTAGCVVALSQMQAMYLLGRDLKWDESAGTMYDNTAGGNILDPTTYQPIICGASDSLLPSGLVLPDPSTNDASAAVWSQAITLSAGASATEATSSADAATSVFPTSSVEPTTSVAPTSSVEPTGSVESTSSIEPTTSSVESTSSVDSTSTIEPTTSVDPTTSVESTISATPITSVEPTTSSVEPAESSSTSENIPSATSDAETSLEAATSQAETSQVVSAETSSIAAVSTTPISAPSTTEASSTIDQPTMVDQSIAIETPGTTEQFTTTSELAPTSEETSQEPSTSQTPSTTQQSATSDSSSSSLASSTQAVAVATAAQSSAAEESSTSQMEQQTTTEEQSTTAEQLQPTTTSEEVAETTQEASATQLVASTTEEITTSSSTLESTIYTPTSTSASTSSTESSTAQAPPTSTVTDAEQITSSSAAQEQPSSSASYSSLAADASDVSSLYSSEVSTSTSEAALVSTSAQEERPSSTFEETSTTSQSSTSAESTTEAQITTLEPPAEVSSKSVKATTDVSEASSSEYVEPSTTEQSSAMQYTSKPSTPFTSAEEITTTAAQPTTVVSQDQQPTPEISEESTSLSAASTTSGYETSTTSEASAESTAQTATSSQMAVQQTSATQQQASTDETPSQAGNIGAASSTSDSSSLANVASSVESWKAASTSEAWASEASGTSDVWSSEASGQSSSSSSESWFEASSAFYGSDETSYGAFSMSTTSPTPTSSSDSDSVDGDSPFVFTAGGTTIGQFTGAGGVAAVQTDVTASGSMSASEGLSDGMGGEADADGLGATLTFSWAENGPTQSQWTSDVTTAIGTSTESSSEASSDLEQTMTSESTAASGLIVPTEKASVAQRPGDSLSDGSIMAQTTMPTTTRAGNSVSATASGNASEQVDEEGSEKEGPEESAASDTGDEGLSASSGTLSTTSLSSDDTAHLTNSSSGSLPTPVNPQLSTYFHTGTSSQSEKVSGSSVTSDSESESVNSIPTSSSGILAAVTEPVKQGLSSAEAASAHAGISSQSAEISKDDSSEVSSTITSTGRAPISSGVLAVASDTVNSSSLSNMVSSWAAQGSSANREASVTEPASSSVTSSWAQPLSNHTTSRSYPYSLASSASAVTVSASAESTDSNDGGKSSAQDRNGQGRGSKSSGSGKTCSRRRKEKKRAERARAKDVGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Z2</accession>
    <name>A0A1E3K5Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L198_00006</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035140.1">
        <property type="nucleotide sequence ID" value="XM_019172198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Z2"/>
    <dbReference type="GeneID" id="30189221"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="ODO08283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="706" mass="79129" checksum="911D7C86EE2D2156" modified="2017-01-18" version="1">MSDPRPETSLDDTPRHAGTAPVRAEYLIRATPIVESTSAADLNDIHPADAAKGHTPSDSRDSRDGGDSRDSKRRKPNKADKKERKGQNKGRKFAIVREASVRICRAWETTGECERGEGCKFKHSWEGYFEVKPADIGYRPEWEKRDEPPYVRLGERLVGGEDALGKTLDLNTVCPVYKDLGYCPFGWRCRFLGGHINKVDPAKEEQKGGPQKRMGEWQVEGWEQSELNEEGWKQGETNWPEFENLQNLRHSTAAFPFSTAYLAHVDPEKPFTLGDRNDSRNKPQKRKKTVVLDEEEAANEVEGDEEAQNQVEEVKGYVLGESESFDVPMRPEEKRRLNWEGGRYLAPLTTVGNLPFRRLCVDYGATITISEMALAQPLVYGAKEEWALVRRHASEKMFGVQLAGGFPNRMVPAAEVLAREVGSGVDFVDVNMGCPIDLVFNQGAGTALMDSPGRLGKILVGMNRALGEIPLTVKFRTGVAHGKPNAHKLIPRFATEWGASALTLHGRSRQQRYSKPADWDYIKSAVTTLRESVADANLPPVPIFGNGDCFSAAGYYEEMERSGVDGVMVARGALIKPWIFTEIKERREWDISAVERLEGIRKFAEFGLSHWGSDTQGVNITRRFLCEALSFQHRYIPIGLLERLPAKMNERPPAYRGRNELETLLASPFVGDWVKISEMFLGRVDEGFEFVPKHKSNAYGGEEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K670</accession>
    <name>A0A1E3K670_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035533.1">
        <property type="nucleotide sequence ID" value="XM_019172591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K670"/>
    <dbReference type="GeneID" id="30189624"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="155" mass="18066" checksum="A5BD2C3D56C70BFA" modified="2017-01-18" version="1">MATAFDPETAGNAGEIEMQFAVKTVEHLEAYEKILQTLPPKLIKFTPIDEEIYEDLLEVFPEFKFEENLRTLNEDEMKSRQGKERWRKFIMPYEKKVTDYNFGTLVRARSDELYTETNSVLVTRVQFFAIEIARNRAGLNQKVYDDAQAKKAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6C0</accession>
    <name>A0A1E3K6C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035411.1">
        <property type="nucleotide sequence ID" value="XM_019172469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6C0"/>
    <dbReference type="GeneID" id="30189499"/>
    <dbReference type="OrthoDB" id="2594763at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024491">
        <property type="entry name" value="Se_SelK/SelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10961">
        <property type="entry name" value="SelK_SelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="109" mass="11071" checksum="0FFCFF7A932BEB3E" modified="2017-01-18" version="1">MSDKTPYVSSSGALTSQPLYNRISNSASDMATIVYLFFETLISPIANPASWTDPSARPAQRAQRPARRSAGGGGGGNGPRPGGGGGSGFMTMGDIRGGETVDGCRATCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6E3</accession>
    <name>A0A1E3K6E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphogluconate dehydrogenase NAD-binding putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035609.1">
        <property type="nucleotide sequence ID" value="XM_019172667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6E3"/>
    <dbReference type="GeneID" id="30189700"/>
    <dbReference type="OrthoDB" id="2575802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="31006" checksum="CAC81E4581D20199" modified="2017-01-18" version="1">MGASLAHVLSLRLPNLRLTSLSHRSPSTIARAAASGPSVQEADVILSALPPSEAVKLAKEVAGHLGEKKPVYIEANAVSPETVAHISSIFQPHNTPFLDGSIIGFPATNDLGSIPKLYLSSRPEWGDKLREVAGVLSGGGDGKGLRVRVMKDAGEGGASALKMCYGGINKGAIGLAALLVLSQAHSPGTAKALLDEMIESQPAFTQKLPKAYRWVGEMEEISAFITASIIGTPLASQHTNSADTFQGLAQVFQRIADDLKQKESVEKKDEEVKGLLDWAEEGKSELERRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7B9</accession>
    <name>A0A1E3K7B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA cleavage complex 2 protein Pcf11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035671.1">
        <property type="nucleotide sequence ID" value="XM_019172729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7B9"/>
    <dbReference type="GeneID" id="30189762"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="656" mass="71699" checksum="531015C2B0547E60" modified="2017-01-18" version="1">MAYPSYPAYQQAPYYPPPVAVQPPADLFRRQYADRLRALTFNSRPIIQDLSMLALAARDRNDWEGMQIVVEEIEMAVLRAPPTQKLPLLYLLDSVSKNVGSPYTTHLLPPIIPRLYVRTYREVDGVTKAKMEEMIGLWRNGGPNGSDLYGAGVRDQVERELFGAAGYHNSSAGPSRQQVQSLLNATLDGKRRELAVRPADGQVAIQMNALQGIGELLNTSNISPQELSAIMAQLKSMAAAPRPPVPTPLPVPSTPAWGVAPTASAPPASLPPFPPKLPSTGNGWPPPVRPPFAPTLPTPSTVVSTPPAPHLNTPIPPTGSTTPATVAATPVAAPVAPIPNLPVDVAKILQTLNKSGLGSQPRTPEVPLSSTPVPPVKSSLEAYEDLILGMDTRLKSLTLNVPHRLSFDHLPHQCNQCGERFASDNAAAKAHMDWHFRRNRQERETGGRGAHRKWLPRVEEWIKNAVELPAVSDQATKTENSAISSERLAQLRQRWVPAPQDSKKASVCPVCKEAFKAEWSEDEEEWVWRNALIINKVHYHATCRAEQTSAMKRLKGDNSRRTSSSASPAATAADEQTPPKRKAEDAQYEGDSAKRVKLEEGSRGDGEHLGEATLPQETVKREETKEDAIEDNQSLDIVMGYQQIDGGGTEEQEVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7Q7</accession>
    <name>A0A1E3K7Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Fructose-1,6-bisphosphatase, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_00695</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035811.1">
        <property type="nucleotide sequence ID" value="XM_019172869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7Q7"/>
    <dbReference type="GeneID" id="30189908"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000008">
        <property type="entry name" value="Fructose-1,6-bisphosphatase, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006779">
        <property type="entry name" value="PRK09293.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="17">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="18">
        <location>
            <begin position="212"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO08956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="37834" checksum="87E1880EC50FDDA8" modified="2017-01-18" version="1">MAAPQATLGADIEPPATDLITLTRHILSQQRALGVDASGDLTMLLIAIQVTSKYIATNVRKARLINLVGLAGAENVQGEDQKKLDVLSNDIMVNALRASGKCSVMVSEEVEEAIIVGGSKGTYCVVFDPLDGSSNIDAGVNVGTIFGIYKVQDGAKPSVKDVLRPGKEMVAAGYTMYGSSCNLVLSAGQGVDGFTLDEGLGEFILTHPSIQIPNRGKIYSFNEGNAQHFYPPTNDYLNSIKFPENNKPYSARYIGSMVADVHRTLLYGGIFGYPDDKKSKDGKLRMLYEAFPMSFLAEQAGGVATTGKERILDVVPTSIHGRCPVFLGSKDDVEDLKKFYVGYENSERNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K837</accession>
    <name>A0A1E3K837_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">L198_00119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035249.1">
        <property type="nucleotide sequence ID" value="XM_019172307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K837"/>
    <dbReference type="GeneID" id="30189334"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="348" mass="37842" checksum="F92BB01EB89F7DF4" modified="2017-01-18" version="1">MSVQVTPEQMSQLRDTLLNTAGTTPLHERFRALFMLKAVGTDEVVDIVSEGLKDPSPLLKHELAYVLGQLLNHRALPTLSGVLANPTGEHCAMVRHEAAEALGAIGAEESLPILRKYRDEEENREVRETCEIAVGKIEFDLSEEGKARKQNPDYPTIDPAPSAEAADIPSLTAELLNPKLPLFHRYRAMFALRDYGSGSKEAVHALAQGFSDGSALFRHEIAYIFGQLSSPYSVPSLLKRLRDPVEDDMVRHEAAEALGGIASDGVDPEEGEGEGEELPEGGVLQVLREWAVKADAPPVVRESCQVALDMWEYENSTEQFNPLDSLGAKENTTGMERSAAAAVAAMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9S3</accession>
    <name>A0A1E3H9S3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000070">
        <property type="protein sequence ID" value="ODN73102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027753.1">
        <property type="nucleotide sequence ID" value="XM_019180267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9S3"/>
    <dbReference type="GeneID" id="30197512"/>
    <dbReference type="OrthoDB" id="2574270at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="352" mass="38807" checksum="4FB5317D34ADB5DC" modified="2017-01-18" version="1">MPAPPSTPATAKRSNKKTDGDDASGWRWKHNKKNSTICVGLDGRTGEDHLIDWMSVPENWAAYSDSNDRAKFAATVIYKWLLEKQIKNFDKAKASGVQDRIQKMKKAFDEALAIQKPTGEGVTEDDLARGIETWEAKIKEKCPFFFTLLPSLKDRNANITAQSSVHQMGDREVSITPSMARRVSSRSDIEDQSVGMEDEADENDDIFSVRGTRANSLSTDITSNNHGVADEPTSGARGAGSLSNGSRARASLNAQDTPTSGKGRRGNANMNEQLQGLFKDHSTANIKGRKEIAEQQASHNQQDVHDRLSLRSPLTYIRHEDGVGLLVRWEGRERAAEGTSCVGGQRYMASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH06</accession>
    <name>A0A1E3HH06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027900.1">
        <property type="nucleotide sequence ID" value="XM_019180131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH06"/>
    <dbReference type="GeneID" id="30197371"/>
    <dbReference type="OrthoDB" id="2574952at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="20696" checksum="12A6A988523DAD19" modified="2017-01-18" version="1">MSSSWSLPPKTPGRQVYPDYCTAQAQLSTQIGSTSDPGRMGIYVCLLDDRPHLYPSLAALHKHRHVSHSIPLPLPLPLPLPLPPPLSQTGVQAGDAVDTVSRAAGGDISMSEGTEGTEGSGSHTPTPTAEDRDKDGPSATSTLPENVKALPLLSLSGLQDQKDQKDQKEEWFHWHYTSQQEARRKSFLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HK13</accession>
    <name>A0A1E3HK13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027980.1">
        <property type="nucleotide sequence ID" value="XM_019180033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HK13"/>
    <dbReference type="GeneID" id="30197271"/>
    <dbReference type="OrthoDB" id="10316677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="25870" checksum="FA77555BA860E66D" modified="2017-01-18" version="1">MADLVEKITWIEGENRKDCVSDEIKERYLAFDGSWKYEFPHVGPQFWLYKDHLGKIIQREEAEAARELDKRREVYLKDFEEYGYSRYRKTWHDVLCRAQGVESLRLIQQGKLSHLLEESEFACHHGKKSADQVFTVFHIFDANWAYFIDFHHEKMEVWSEGMLVREVTFDMLRGNPDCMRDFNWFKMRDTDWYEMPDTHWYHKDDDRDEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HQT2</accession>
    <name>A0A1E3HQT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028029.1">
        <property type="nucleotide sequence ID" value="XM_019179968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HQT2"/>
    <dbReference type="GeneID" id="30197206"/>
    <dbReference type="OrthoDB" id="10445741at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19688" checksum="911C4035F36F0502" modified="2017-01-18" version="1">MSDKDSDNELKLDLVGCKLHDLEFFDDGKQALPDKSYRAQAAHLITFGEVKKNQSIYQAILQASTYGQATFGSQPNRRGVRFVVISFNDTKVQGAIGEIDMAGIYLTHIHNLKDDYEYTRFWRLLAGMYCSPIDDAGCNRRIRFYSNEAGNMVLEKWSYPQEVWRCSNKTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY77</accession>
    <name>A0A1E3HY77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028241.1">
        <property type="nucleotide sequence ID" value="XM_019179760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY77"/>
    <dbReference type="GeneID" id="30196985"/>
    <dbReference type="OrthoDB" id="2565090at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="36340" checksum="8203A9CE69848D93" modified="2017-01-18" version="1">MPYSLRTRTRQPLAPLDLPEDRPMLKRSPSSTSLRSPQKHSKLDPPPSPGPSSSRSRSVLRSGGMEGKRGSVTPRMSLSKMMGRGEKGMDGARSPARRLFGPETPTSGISGAIITPPRLAPSPPMDGSTSSPFVVLPTSSNVQNLPNTGAENGQDGQHDPGFVILPDPKGKGKSKAEAGRTATTPTRLRRGRSRSRSVAAEDGADLPPLASENQENIPPPPPVPSLPPHLPEYKSKLPPSPISHPSLSRSTTTTSPSSSPSSSLLPPPMAHSASWSGTPGRRRERSKLVNELLMVRGETEMPSFLEEQAGLEEGDELTPGKRVLRSTRGKQKLAEEVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5H4</accession>
    <name>A0A1E3I5H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028388.1">
        <property type="nucleotide sequence ID" value="XM_019179620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5H4"/>
    <dbReference type="GeneID" id="30196841"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="496" mass="53809" checksum="61A77E0F78FA1741" modified="2017-01-18" version="1">MSSSADKKDAHLTANLPTLKANITTVGVEAPPPPPESKWMAIYRSSFFQICVVSALAFCGPAMADAISGLGGGGQATPYTVNAATCASYCAVALISLLGGPIASRMGIKGMLIAGASTFAINGSAYYVNSMYGVQWYLIFGRFLYGAGFGFWYVAEAAIILSYPEEGRRGKYLAIWVGSRNLGQLVGGSISLARNAKSAAAGAIATSTYLIFIAIEALGFPISFLISPPHKVRRSDGVPILMAAKQPWKTEFINLYKAVISPMMVMLMPIAFYSYFYGGVLSTYLTNYFTVRARALSSFIVPSGIIVFTAIFGRFFLDNKRWSQRRRAQVGFAVFMVPSFAAFGWLCANQARFLNMDTAPKYDWSDKDWANAYVPFYIMQVCGYLCQTYIYWLISCFTASVSSNATNGGIFRCVEAVGQAVSYGINSNTNSKFIPLGINFGLAGFCVVPTVMLIQQVPVWREDAEIQWVGKDGNGDVEGEKEEGKATQSEALDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7F4</accession>
    <name>A0A1E3I7F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028338.1">
        <property type="nucleotide sequence ID" value="XM_019179650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7F4"/>
    <dbReference type="GeneID" id="30196873"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN83766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34509" checksum="5DCFD1A5B9242A8B" modified="2017-01-18" version="1">MSQPQTRKRTDRLAAPSRHSIQDSAKAQVAEVGAIVQDGITSASWIYPILGVFYLFSHPTLIKPLLPTILKGVALSAAAVVFLFTFTYLPQVGILVFVSGPLAFILAIPLVLSEAYFVVTFFARGFLSGQVGVDLFDAVLLQKGHQTLVGNGRQVTDAGGGKAKQLGNLIRKPLARFSFDNTVRYLITLPLNFIPVVGTVFFLGYNGYKAGPGYHARYFQLKDYSKEQRQAFVHKRRGAYLTFGTMAALLNLVPFVSILMTFTTVVGAALWAADLENNIKVTSNLRGEAHKAKTKQADEVEVVIPEENTVGAKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9G5</accession>
    <name>A0A1E3I9G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028442.1">
        <property type="nucleotide sequence ID" value="XM_019179585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9G5"/>
    <dbReference type="GeneID" id="30196805"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15150" checksum="AADD6D4EA5E4B762" modified="2017-01-18" version="1">MAKHQADIAARARRVAHLCSPVVHPPLLFLSSVLPPASKTPPSLVMAQSDKLLGGAMLLVAAFVFVYYTTWALFTKQKKKKPFLPSDSPLQSLFPAREWAIRLPLFVLLTGISVIGLFFGKVLLGEARKKKQKAGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA61</accession>
    <name>A0A1E3IA61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028457.1">
        <property type="nucleotide sequence ID" value="XM_019179600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA61"/>
    <dbReference type="GeneID" id="30196821"/>
    <dbReference type="OrthoDB" id="10474960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36849" checksum="BC5E05E3C33A2961" modified="2017-01-18" version="1">MSSATLNTDILHHTLALLPASSLATSLLASKDFYRLCSPLLWREVELDLGKEGVEHPLVKALIAGSRSEVHGDGWSTSPAPYVRHLTPLAHTNASPCSHIHPPVSTSGPHTNPLPNLITLHLTIHPSSPVGWSFCAPSDRERYPIYPATLPCPLLEILRPRRLVISQVRGLVSPTPFRKGCGVWEDVREVVVRLRVGGGMWSVKGNNCFWEMLGDKVERIVVVVDDLKGRALPFEGEKIVKDIRDRVVPLALKRGISILVVNLPVSPQNFEMAGSRDGYAKGDVGDVMVEGEGEKGEIKFETMEGWLKTGQWVGVFSQQEVKVLDYYSQPSFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBG5</accession>
    <name>A0A1E3IBG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 13"/>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028428.1">
        <property type="nucleotide sequence ID" value="XM_019179571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBG5"/>
    <dbReference type="GeneID" id="30196791"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000047">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110357" checksum="AFC8462734593E57" modified="2017-01-18" version="1">MVPRVHRLLRQNSLLSIRPRTTSISPSTSLLRRSVATENQIHQPVHPELDDSFKDLIENGMAMGMGLKGKDRVSLPRRILEELEYADVRDSNSGMELEGSLIEPSTAGDGLVIDEPPTDARAKAGEEYDAYGREERRSPAAVLGSKRLGMVVLPEEMRDGIQRQISMLDNPRDLRKSYLSLPDMPLPANAPKPNPREKTFRTPEGELAKASAILPGEYSAVKNVLEEMERRLGSAWTKGVKEGEIVEFSPGLGSGLWASLDTFGGLHSTRRLSEHGQPPLKYQFVHPSRHGLDLLQKITEAIPKESANIQYNRKHSPTSTPSLILSTFHLASFPTPQTQQLYLRQLLSFDSPYIIIIDRATPQGWAAISKARSYVLQQSTPENPLHIAAPCPHDSKCPLLDTREVCGYTQRLQRPSFLRKTKHSTRGEEVKGYCYLVVAKGERPVAGQVSESIKALGRTGKVGREAAEKALAKSQGRAVLREVEGHEAILEVVPEYEAAPEQNAAAEVDEAELETSLRKEAYSWPRLVASPMKRKGHVTMDACTAEGNIQRITFSKSLSKQSYHDARKASWGDLFPHSPKAKPVIRDRGIRRLNQPENFEDSDALIAELLEANAEEEMDERSSLEELEAMGIKLPQAADIVRETQGPFAKGQRRRYTTASHLWPLPRPFAPSQRRSMSARPVASPQIIRTKKTLASLLTQAQSGEPITCLTAYDYPTALLSETCDLDMCLVGDSLSQVSLGHETTTSVTLDDIIHHARAVVRGAKSPFVFADMPFGSFEASMEEGVRNALRMIKEGGVDGIKIEGGLEIVPLVQRLTSIGIPVMPHIGLQPQRAVSLSGYLVQGRTAASAYETIQTARALADAGAFAFLLEAMPRDLGKLITEEMVKRGVFTIGIGAGKGTSGQVLVVTDVLGIYADDPLDSTPAVSPETTTVPASAAEMVKPAFAPRFVRQFGNLGAEMRRAVRGYVASVRDGSFPSTKESYGMKKEEWEGLLRLLDIEKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICI5</accession>
    <name>A0A1E3ICI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028676.1">
        <property type="nucleotide sequence ID" value="XM_019179320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICI5"/>
    <dbReference type="GeneID" id="30196527"/>
    <dbReference type="OrthoDB" id="10271865at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="172" mass="18947" checksum="02EA372D67017CF0" modified="2017-01-18" version="1">MQLPTLTHLTSYWDHLGTVWQITLILWSYLLYLTFATKSYRIRTASAYLIGCFTFPVLTVFWGAMDSRGLALDGIAGDRMSLIYENGAYANIQLAQQNETFYSSPVPPTSAVGESKVYTPTPLVEQVGQVVFTCGKNVTSIGALTPTESALTFVWPEVDCAQDPFIGVQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE33</accession>
    <name>A0A1E3IE33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lathosterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028839.1">
        <property type="nucleotide sequence ID" value="XM_019179222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE33"/>
    <dbReference type="GeneID" id="30196423"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="157"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="38440" checksum="976B368F616E4B6C" modified="2017-01-18" version="1">MDVVLHYADEFALDHVYNYLLPHPSIPTTEKLGLLNTTSSPSPYTSFSTPPLTGSLLSRDSLLRQYISLLSISVLGAYALYFSFCSLSYFFVYDRRLEHHPKFLKNQIRKEIKSSLIAAPYIGIITVPWFMGEIHGYSKMYENVGDYGWTYLVGSMVWFLLFTDFCIYWVHRLEHHPRIYKYIHKPHHKWVVPTPYAALAFHPLDGYAQSLPYHIFPYLFPLHRYAYLGLFVFVQFWTILIHDGDMISGHVLERWINGPAHHTLHHLYFSVNYGQYFTWADVQFDSFREPRPELDPIHESLRMMRKKGLIDENDKPIPRIQNKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IES1</accession>
    <name>A0A1E3IES1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Charged multivesicular body protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028864.1">
        <property type="nucleotide sequence ID" value="XM_019179106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IES1"/>
    <dbReference type="GeneID" id="30196303"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29033" checksum="927F78151725E383" modified="2017-01-18" version="1">MNILVSAGIAAESGLTSIQDTLFGRSTTPAERLRQHQRSLQKAQRELDREKGKLEAQEKKTMGDIKRNAKAGNMNACKILAKDLVRTRRYIQKFTQMRVQLQAVSLRMQTLRSNESMAVAMKGATRAMGQMNRSLNLPQASHIMNDFERESSTMDMKEEMMSDAVDDAMEDEDEGEGEEAEGDKILKEVLDEIGMNMNDSLAAAPTSNPLASEPLQSSRVAVAEGLPPVAPSGPPAGGASASTPGAGGPLSSEETDLQRRLDALRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFN3</accession>
    <name>A0A1E3IFN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028939.1">
        <property type="nucleotide sequence ID" value="XM_019179021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFN3"/>
    <dbReference type="GeneID" id="30196214"/>
    <dbReference type="OrthoDB" id="10303641at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="126" mass="13886" checksum="9396FA624E9709EC" modified="2017-01-18" version="1">MSTTSNAYGDASNETVDTKTKEYKIHPFYRSGNVHFITTDDVIFSCDIDRLAEMSSFFRDLSEIPQPPGKKATTTQMSGQDLHDQLAQLSTEEQGDIATHTDGAVIFPECGSDVLEPWLNLILLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFT8</accession>
    <name>A0A1E3IFT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 (Peroxisomal adenine nucleotide transporter), member 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028999.1">
        <property type="nucleotide sequence ID" value="XM_019179081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFT8"/>
    <dbReference type="GeneID" id="30196277"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="35302" checksum="1CD28F7CC718968E" modified="2017-01-18" version="1">MSDSAIHALAGSVGGSAAMALTYPLVNLSTRAAVQTKKKELTTREAVAKVIKSEGVLGLYSGLTSSLFGIAVTNGVYYAFYEEMRSLLIRRRGNTSTSSTSALTTTEGILAGLIAGAITTLTTNPIWTVQTAQATHATTARNASGAIETDVEGNAKKVKPSAITVVKEILEKDGLKGFWRGIGPALILVLNPVIQYTTFERLVSLLLGFRLAKQGATPTGKTALGRSSLSDWDLFFLGALSKLVATSGTYPYIVVKSRLQAATHKYKSSIKAVLHILEAEGVNGLYAGLGLKLLQSVLTAAFMFVAQRRIYEFVKKLIVLSAERKKLVSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHP6</accession>
    <name>A0A1E3IHP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SBDS family rRNA metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029187.1">
        <property type="nucleotide sequence ID" value="XM_019178910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHP6"/>
    <dbReference type="GeneID" id="30196094"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="243" mass="27377" checksum="5DF418B602EC4B83" modified="2017-01-18" version="1">MNKQPGTQIKLTNVSIVRIKKGGKRFEIACYQNKVSEFRSGVETDLSEILQIEQVFANVPKGQAAKKEDWQKAFGTEDMNKVIEEILRKGELQINNLERTQHLSSLSREIATIVTEMTVDPNTSRKHTVGMVEKAMAEVGFNVKADKPAKAQALDLIKKLSEGEVLPVRRVRMRIRITMPGKDAKRVKEKVIAEVEEVEEEEMDMEWEAIVHINPSNFRTLTDLVNNETKGKGRVESMGSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II87</accession>
    <name>A0A1E3II87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029001.1">
        <property type="nucleotide sequence ID" value="XM_019179083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3II87"/>
    <dbReference type="GeneID" id="30196279"/>
    <dbReference type="OrthoDB" id="2507488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="49169" checksum="AC2C1611B1D4C2BF" modified="2017-01-18" version="1">MSTPREPPPEDNFDDDDFPAAPGGKKRKVPAYGQLKSPDGSEHHHNPPDSSALSTSSKTAAAPAFPLKRKFARSFAYALCEFRKGLFLRRKAAFIALYIDAQAAINATSTAAGATGPAAAAVAKYKASLPDVTNFEKLLPALEDVGVNSWTPDRPGWREDRAEEWRVRARKRKVGGKPVERKGWAPEGSFEFEKECKASTTLRSRVKEQGALLKLAYELRGIVLATHKPTAVVKSTTVPPAEDKPPSKNKRKIDRKHEASAPIPASASRPASPAISQTVSRDGDGKPKKKPKKKKRSVLANQSNPHHVDNYRPSRTVSPQGDPFEPYAYHFDLISPPSMRFLATRPERVTAPLPGAPQKRTLVRPSEDDYVCCFCEYDLYYGTERARRRAIRSRKIELKRKEAIKAKAKNVAEGRGTFKDESEEEDDEDEDEEGCEDDGHGHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIJ3</accession>
    <name>A0A1E3IIJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029222.1">
        <property type="nucleotide sequence ID" value="XM_019178739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIJ3"/>
    <dbReference type="GeneID" id="30195896"/>
    <dbReference type="OrthoDB" id="10466616at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="42025" checksum="217B3BA69BC9244A" modified="2017-01-18" version="1">MTFDVSTDTPGGHAPQEHSLDPSPLSLSALPSEIHSLVFSFYISTTHPGSKAFTNLLCLSRAIHDENINRVYDKIVLTKDKSQTGLRSHTKAEGRATGTGISVRTWLGREANLDRKRGVTFVDAYALLDTARFLIEHGWARWQRSLCAQEEYVKSPQCLFQDLHHVTYPASLFDGTPVSRVAWQTYHDRSVNARHVCIELPAVLLPKTAADALRSSIVYQTPNPVTLTVHNCSSPYDIPLVDVITSNIRVGIFLQSPRGIGLRPEDVWAVEQSQEDELYEYFENVFSKIALVYPNFVVHHSRSSNFVYHLVEEAVGEAGEVGLDLITQDTYDMILDEKKLLVYSNEECVAHEAVECLCGLKVYRSEAIEDSDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJL0</accession>
    <name>A0A1E3IJL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029345.1">
        <property type="nucleotide sequence ID" value="XM_019178644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJL0"/>
    <dbReference type="GeneID" id="30195801"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="171"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="809" mass="86834" checksum="A87478A376D4BE5E" modified="2017-01-18" version="1">MSQSPAPNGVAGPSNSAPAPARPTDSNLLRQFVMEYLQSHGFDKALAMFQQGIAGQDGDASDADVGAGAGAAGVKTEKAGEREAIFRAPGPVPLESNIKRNIPQAQAVSASTMADRITPDFEAQAKYIIDQLQKKVEAVQDEGEEKEKEKDVKDGPPVDGALVDVSDRTGGYLSYRRWVDGGLEMWKTELDNVSFPIFVHTFLELIHLGFLKTARDFFTQQSPHHAPLHPQEISTLSSLSSPSQIAQNPLCKQFLASKFTIPLSRNAHDLLLQWLSGASLDDEWEAGLHSGPGRRREAVKLIVFNHVTIHVTDSSEPLDHVAIASKSGLLPSSLPSNKSIDAFNSATTLKLGPPPMTDKLKEQVTRTLQDEAAAAAGEDEGMDVEAPAVEVKIENEDIDSSLISPAESETLPPVPAVFRIPDLKREVESIKDRRKMVRLGPSGTSEGKGTLPSVVAFTLFDHGENASSVEFTRDGSMMAVGSSESCIRLWSLNGDKLKKKSVDEEGALVEDEGLPMRKLIGHSGPVYSLSFDPLPSSSSTPTSLLSSSQDGSIRLWSLDTYSNLVVYRGHGRDPVWDVEWGPGGVYFASASRDRTARLWSSDRVAPLRMYTGHLSDVNCVKFHPNSLYLATGSTDTSCRLWDVQRGACVRLFLGHTDSITTLAISPDGKTLASSGLDKSIYLWDLGSSRPIKKMTGHTGPITSLSFSQESSVLVSGGTEGVVKCWDVKGAGGEGGGVGGGETMWSGAGGKEEHGALPMGTGDAWDVPHTSDLLATWPTKRTPILKAHHTPRNLCMVAGSFAPPSNARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJM3</accession>
    <name>A0A1E3IJM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029348.1">
        <property type="nucleotide sequence ID" value="XM_019178647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJM3"/>
    <dbReference type="GeneID" id="30195804"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="35244" checksum="7BCA61A179409469" modified="2017-01-18" version="1">MVLTRRQATSSPSPSTSPPIMSDTTSLLGQSRTISYEESLSILPWQTDNDYIRHGYRRPIPSIRGCLWSAVRYIHNETINIHSHSIGVVFFAVLLPLHLIPSQFPTLHHFPVDPLTPPTLHDKVALTVYLVCAVSCLSLSSWFHTVSCHSEDVCEAAHRGDYMGIVILIVGSITPGMYYGFYDSVVLQAVYMTAIVGAGITSAYIVLSPHHRAHRWHRTLTFIGLGLSAVVPISHILIAHGFKYARQTMCLDMILAGGACYIGGALLYAARIPEKLSPGTFDYFGSSHQIFHCFVLGGAWFQYAALRGMVWGRGLALSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKK9</accession>
    <name>A0A1E3IKK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029295.1">
        <property type="nucleotide sequence ID" value="XM_019178812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKK9"/>
    <dbReference type="GeneID" id="30195970"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="47213" checksum="F7FA8EA679359961" modified="2017-01-18" version="1">MVEQRCGRLEQLLRQAVPDIDLDEYVGPPIDPETFDIVDYKVHSAKFVSDPRVKIPDDIGGYHPYSAGWRYMRVLLRTGYNFLQSPSLYSLQKTVLVCQFFQGSSTVPHTLPVISSLGLRFSEELGIHVGQLLHHVNPVERELYTRAFWCLYHIDRYNCTFVGRSVAMRDCDFDIEYPKDVDNEYWQLDFKQSEVKVSRVAVFIQTCKLDRIVGRIMQTFYTVESSSQPVVSLRRAADEISADLDVWTEELLSVLHWDPERGDYRIFQQTAALHTYFHYCKILIYRPFISSSGSHPKNDPLETCLSASYSISDILSACLHRGRRESCQPGHSLDISYILPPMTHSTDEYEQALFHAKVILAASKDSEVVWRQCGKVTDCLTHFVKEAGEWRIMGGREGMEGGEDDMRGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM36</accession>
    <name>A0A1E3IM36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_06348</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 19"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029569.1">
        <property type="nucleotide sequence ID" value="XM_019178413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM36"/>
    <dbReference type="GeneID" id="30195560"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="429"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN89660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="58103" checksum="F7EAB6B7EE26E8DD" modified="2017-01-18" version="1">MSTTAAGPNPNAPPRPTALLNTADALKHLDEYPRGDGLSLQELMDSRKNGGLTYNDFLILPGHINFPASDVSLQSKATKNIVLNTPFLSSPMDTVTEDRMAIAIALHGGLGIIHHNCTAEEQAAMVRRVKKYENGFITDPVCLGPDATVGDALDIKAKFGFCGVPITENGQIGSKLLGIVTGRDVQFQDAETPIKSVMTKDVVTGSFPLALEKANSLLRETKKGKLPIVDASGNLVSLVARSDLLKNQNFPYASKVPESKQLYCGAAIGTRPSDKERLKLLAEAGLDVVVLDSSQGNSTYQIEFIQWIKSTFPKIDVIAGNVVTREQAAQLIVAGADGLRIGMGSGSICITQEVMAVGRPQGTAVYAVAEFASRFGIPCIADGGIGNIGHIAKATALGASAVMMGGLLAGTTESPGDYFYHEGKRVKVYRGMGSIEAMEHTQRGSVAGKQSMLGLDNAATARYFSETDAVKVAQGVSGDVADKGSINKFVPYLYTGLQHSLQDSGIKSITELHEAARSGDLRFELRTASAQVEGGVHGLNSYTKRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INH5</accession>
    <name>A0A1E3INH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029664.1">
        <property type="nucleotide sequence ID" value="XM_019178226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INH5"/>
    <dbReference type="GeneID" id="30195372"/>
    <dbReference type="OrthoDB" id="5540949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13897" checksum="234AFB86A47D596D" modified="2017-01-18" version="1" fragment="single">MSDIGQRRAEAETIVNILLVVATLQQTLDLPDDFDSCDPDFTEYFLQLIILLRASSLPNWQSHIGWLGLFTPEMTLLAMDTFSNYLQYLQQTRSVARPLTYNRRQRLGENVWFVIFDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INH6</accession>
    <name>A0A1E3INH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAT family amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029682.1">
        <property type="nucleotide sequence ID" value="XM_019178244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INH6"/>
    <dbReference type="GeneID" id="30195390"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="60"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="571" mass="63271" checksum="11FDEC892B2B695E" modified="2017-01-18" version="1">MADLEKDDKLGGSQYQVPYESEKVAEGNSLDPHAGELGGCEGNTYHPGENHVKRQLKQRHMAMIALGGAIGTGLFVGSGSALASGGPVGLWIGYILMGTMVYAMMVALGEMAGEFSLFPVAGGFVHYASRFCDESLGFATGINYWYSYAITIPTEIIAAQIVITYWDSNTHAAVYITVCLVSIWFINFLGARAYGEAEFWFCTIKIIAIVGLIILGIILMCGGGPNHDAIGFRYWRNPGPFAQMTINGGDDVIEGTWGRFLAFWNVFVQAAFSFIGTEIIATTLGEAENPRKTVPRAIKRVFFRILFFYVGGIFVISVLVPYTEPNLLNGSGTAAASPFVIAIENAGIKALPSIVNAVLLISAWSAGNSDMYAASRTFYALALDGQLPRIFRRCTKSGLPIWSLVITGAFGLLAYMNTGGETAEEAFNWLYNLSTITAIVTWWTILLSYLRFYYGLKVQGISREDFPYKAPLQPYLSWISFVFFTAVILFNGFTVFLTGNWDTGDFIAAYITLPIFAVCWVGWKCWKKTKWIPLAEIDFETGRREFDELEVTDREKYMAQNKFEKIMDFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INQ5</accession>
    <name>A0A1E3INQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029756.1">
        <property type="nucleotide sequence ID" value="XM_019178318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INQ5"/>
    <dbReference type="GeneID" id="30195464"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="512" mass="55025" checksum="C8014B0FDCB4505A" modified="2017-01-18" version="1">MAPPYVPTPEQIALAEKRRAERAAKKAAIASGAVADPNKAKGEGQGEGEVALLKRDWVAVGPGQVEGGAGGQKGVRILTWNLLAQTLVRTKLFPGSDCLKWGDRKALLLAEMAHHGSCDIICLQECDKLSEITTSLPKHAFVKGTGPHKSHGLVILYNKEKFWAERKELVHLDFEDLHPPSQNGGEGKGEEKKGDGEEDSGEMKRRKGGSRMTKNVGLIVGLKYKDESGRGIVVATTHLFWHPLYAYERTRQALLLIRAIRRFQGVHGLEGWPVVFAGDLNTQPSESTYFLLTSPHSPLPASCAAQVESSRIVHDNLKKMSFTAPRTVPVTTHADASIPPGTGSLPASGTPTPVPTKTDEEKDEDREDKKDDSTANSRPPLVSDGIPTTEEMVGLFRDVFPGGGCESAYGSTGWRVGRDVAGFGGRGGFGGSKEGEGEEGGGDEPGYTCFTPLFKLTLDYLLLLPPLSPSSDPKARFSKVLLPPRAEELGEGLPRKGICASDHVAVGCEVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP27</accession>
    <name>A0A1E3IP27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase 2 (Formerly 2A), regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029707.1">
        <property type="nucleotide sequence ID" value="XM_019178269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP27"/>
    <dbReference type="GeneID" id="30195415"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="403"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="601" mass="66338" checksum="E67DE84A67A8ED97" modified="2017-01-18" version="1">MSDPSSELYPIHLLMDELKSEDVVLRLSSIRRLSTIALALGPSRTRDELIPFIQYQLDDEDEVLLVLAEELGNFVEYVGGKEYAYILLGPLENLTAVEETLVREKAADSISKVSVLLNAQDLDKHFLPVIERLSTGEWFTSRTSACALFAAPYPNATPSTQQKMKQLFAGLCSDDTPMVRRAAAKALGPFTKAAGTVTDQHALLVSDLVPVYRKLSSDDQDSVRLLTIPDLIALASTLTAEETKTHLLQSMRHSITDKSWRVRYMVANEFVGLAESAGESIIREELVGAFVGLLKDNEAEVRTAAASQIPGFAKLVDREVILARLLPCVRDLATDSSQHVRASLAEQISGLAPLLGKDSTIENLLPLFLQLLQDEFSDVRLNLIGKLDTVNEVIGIDRLSQALLPAIMKLAEDKQWRVRQAIIEYIPLLAQQLGVEFFDDKLGALCMSWLGDTVFSIREAATINLKKLTDVFGVEWAKNTIIPKVLEMGNHQNYLFRMTTIFAITTMAPSLDTPIIRDTVLDAALNLANDAIPNIRFNVAKCLETLAVVLAQTPEGQELIHRKVAPALRKLQDDPDADVRYFATKASERTTGDGSEPMVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ37</accession>
    <name>A0A1E3IQ37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029816.1">
        <property type="nucleotide sequence ID" value="XM_019178097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ37"/>
    <dbReference type="GeneID" id="30195242"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29926" checksum="FC2554089AA7D5AC" modified="2017-01-18" version="1">MSTEEIPKSVLPYPPIHKDAQFVVLSDWDGTITDRDSNDLLVDNLGFGFDKRRALNIECLEDRICFRDTFKEMLESIDKPFEECKEYLKQHIKLDPGFEKFYKYCRANGIPVVIVSSGIEANIRAVLSTLLPGPEAEEIEIIANDVKFTDSEGKGDKWDIVFRHPTSGFGHDKSRAILPYRDLPHRPTLFFCGDGVSDLSAAKHADLLFAKTMPSGHSDLQTFCQKQKINHLPFVDFNKVLEKLQEVVAGKTVDDILSEEGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISD7</accession>
    <name>A0A1E3ISD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030074.1">
        <property type="nucleotide sequence ID" value="XM_019178035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISD7"/>
    <dbReference type="GeneID" id="30195176"/>
    <dbReference type="OrthoDB" id="2579977at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129925" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="97"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="39693" checksum="C82E5DCC7FED1D7A" modified="2017-01-18" version="1">MVHFLSATLFALLFPLVTIHAAPHKCDLSGASSLAQESVTVSLSKETDDAFGAAAIATTDGYEPPPSATINKAYSSDSSSTIASTQTESESTPISSSTSSAISSPTVSSNSTSSSSDCSCGYILSSHSNAYFPKSHAVSFSSLSSLADSDFEVTDGWQVGGVGSDGTRSVGSTNNVKIIDGDMVLTVPGGQSVGGEVTVAEVTFKEVVGGGVFTMEAQLDGGAGTCQSIFTYTQSTDVGNDEQDIEMLGQSLLTSAPKGAEPGIQLTNWDPTNAGENEEKTTAFPDDPTTAYHNYTIGWLPGGTKYHYDGQDLESPSKYASINPSNLIINNWSNGDASFTAGPPSADVSLRVKSVTFYYQSETLESYPAYPSGCSEVDACVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUQ1</accession>
    <name>A0A1E3IUQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030067.1">
        <property type="nucleotide sequence ID" value="XM_019178028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUQ1"/>
    <dbReference type="GeneID" id="30195169"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000021">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="660"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN91441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="106247" checksum="C2494FDD6B469F6F" modified="2017-01-18" version="1">MPASTSDGIQDRPSRPLVVRCGYEGSSRRVNFPSAATCRLESLRHRVEDCFSLSASPFALIYTDDDGEEFSIRSESDLTDAISYFISGDDDANMSTYSGSGSGSLPYQLSLSKVTLRLDVIVEYDGPSLSDTSSISSFQTESERDSAYHSSAYGSSYRSSVVESMQEAMEDDVTEYGEDDGASQASHSISGRMSGLSYEDDRPSRYAGSITPKRRSDRSRAGSDYRGFNQKQLSVPQQPPLTGPESDAAPSLLTHSELGSRWLREQSNLNARKISGNSRSGRSNRYDSDEESFGSDDDRSNNFALVRDARGRYYYSYQTDSSNASDVDLAENDAVSRRLSHNSTSSSASTTSPPLTLLSHLHDPSAQITEPSVPPVIAPDCSACGVRLDYLRYVCETCGEGEMWKENASGKAAFVPPRVPSESSEQSDGWSDATEFAAAATSSNSGSRTVYDTASRSRSGSLSTTASRGSLQTLAGSSSSPTSITYRPFLGPTPPQSPDAENGQLIPSLARGDLPTRKTGYELCAGCIEVHGIQHSKAAARAAKLELSSSEFRHARRAGELRHTFKERIWGPVGWDDVEYNEDTECTICRIPLFHNRFKCVSCSKFDLCRSCYRKVDEIHPAHSFLSLPDKPLPRIGPARSVSSDEDGTQGAAAPQLARHPGAFCHNCLQDIVGPRFHCAVCPSWDLCIQCEGIYMAGGDGSGHLADHIMMKIPVPLPSSEVEAVSRRARDRWFQQDRTVATSAATPFEPSSRSSSPSGDHSTVYAPTATRDRGPSPIPPSQIINVTQRDALDHGIRCGNCTEWIMGRRYQCAGCPSDPAGFNLCSICELRSYKVHDPTHVFLKFDRPVNIPLRSRRAILPPLYRHPVGKVPSAALATINPRDPTAYLKHVMHRETLCDVHGDQIRGVWLRCAHCAAGFDICREAERVADHDSTHVFVVFKARVDMTTFRQVADLAATHSKPLLRQQVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWE0</accession>
    <name>A0A1E3IWE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030372.1">
        <property type="nucleotide sequence ID" value="XM_019177621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWE0"/>
    <dbReference type="GeneID" id="30194752"/>
    <dbReference type="OrthoDB" id="10490994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="378" mass="42448" checksum="46B4B9713157E803" modified="2017-01-18" version="1">MSVSGLTISITYSPFPPDFDLRLREVAREVVSEEWDQRTPKIDPAAPILPPQEPELAEAIRQAGPKGEEREEAFNRHKAPLRLVDNNALAIAKVNDAPQGPPTLPLQVASKQGTFSASHQSPLRIPQAGKSTIVVAHALHVPVPAGQASKNDQYRTYVNKYHQSVKIHPGVITAPSLAVMESAKERSDKLAHKIWLGMTKFDASLIATCKEAPLLRTSVTSRPEWFFVEDPEWWSPLMRTAFWTSFYMDPPVDIQIFRLPGNIRFSHVTTSSQLPPPTTVYRALVDPMFLNEKAFKSWAKFVPNPPKASAKAFASKPSLQSLLEARTDGLCDKVKRHTMVLKDLGSERRLDLLVRRDEDPRSFRALVRRDIWGLRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXQ7</accession>
    <name>A0A1E3IXQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030484.1">
        <property type="nucleotide sequence ID" value="XM_019177331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXQ7"/>
    <dbReference type="GeneID" id="30194453"/>
    <dbReference type="OrthoDB" id="2578383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130077" evidence="2">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="11634" checksum="33B741663E8029AB" modified="2017-01-18" version="1">MSAIFHGIEALHNLLLNIFIFTLLPQNVLEPPAPNVAMLRGLVQDLAAQETRDSVGQIVDPRPPVDPQASLPAPSPGGRQTRCRLLKGPVAQGTRKSQALRSRLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXR6</accession>
    <name>A0A1E3IXR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030494.1">
        <property type="nucleotide sequence ID" value="XM_019177341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXR6"/>
    <dbReference type="GeneID" id="30194464"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000092">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="74"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="754"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN93389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="994" mass="110791" checksum="0D10AB754CACE784" modified="2017-01-18" version="1">MSPLLRSSLLLRSHLFPSPSIHHIRYATTSVAGLSPQEKKKAFSHTLKLPKTSFPLRHKDIVAAEKLQRRKTCDQLYQKQLANNPKEAFVLHDGPPYANGHLHMGHALNKVLKDIINRYKVVRGHRVHYVPGWDTHGLPIEQKALAAIGKSHTSLTPSQVRAEARQVALSAIDVQKEEMRALGIMADWDHKDGTYRTLDIDHDFEIRQLELFQTMIQKELIQYRLRPVYYSPSSRTALAEAELEYRDGHKSHSVYVSFPVQEEDMSEGLRAIYSRHKSWSSGVDLAIWTTTPWTLPGNSGVAVHENLTYDVVRNDHGRLLVVANDRVADLQRIFGHLTVVGSLPGSSLVGSRYTHIFHPPSSPSPKPQIFAGGHVTAGTGTGLVHSAPAHGHEDYVAFNNAGILPDKLRCPVDDAGCFTDELMSWVEDEKFRALVGKAVLGEGTKTMVELLRGEGVLLGDEIIEHRYPYDWKSKQPIIVRATPQWFADVEHIKDDALDALKAVHFHPPQARKRLETFVLSRNEWCISRQRSWGVPIPVLFDSHGGPVTDADALAHVIQVLKREGTDHWWSGPVEDFVPPSRKGEQLSKGVDTLDVWFDSGSSWTLLRDSKIRDPELPLADVYLEGSDQHRGWFQSSLLTKVTSTSDRRAPYGTVITHGFVMDEKGDKMSKSTGNGLSPMEIIHGLGDSPAYGADTLRLWAASVDYTCDASIGPSSISHASETLRRLRNTARFLLANTSEHEKVSLEDVELRAIDRYVLHQLHDLELVALAGYDSYTFNKVVNALSTFAVSTLSTLYFDIVKDTLYCEKLDSPARLATVAVLQTVLKRMIQIMAPIIPHLAEELHQNTNPLEDSSAFLGTWEPSDIWSDPALQKDVGYLLAIKPLVSQLVEEARAAKHVKMSSETELWIAASGISHTVLSRNANLLQSLFGVSRVTLGTDLSSRESLASVDAEIDDARVSLKLLPSSQHQCPRCWLYQSEVVDHLCTRCASIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW4</accession>
    <name>A0A1E3IXW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide alpha-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030373.1">
        <property type="nucleotide sequence ID" value="XM_019177622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW4"/>
    <dbReference type="GeneID" id="30194753"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="902" mass="100265" checksum="643FF6AB321AC372" modified="2017-01-18" version="1">MVPFLRRSGVTAKPLPGAHFSTLESQKQSSLPLTMAHIPKHRALPDKENKLFRELLTQYELKQYKKGIKAADTILKKFPNHGETIALKALTIHSSLPDPMTASAVPKKEEAKAMARLAVKKDITSHITWHVLGIFAKSERNWDEASRAFAQARRLDPDNIPLIRDSISLLTHTRQYSQALQARHHFLTLRPQIRATWLGLVVAHHLAGDADEAIRVYNDYTEATAIDGATAPEKAQTLMYVISLCIEAGRKEEALERLEAGVKEEVISPRGQVSLTKAQLLGELERTEEALKVWEELLKQNSDSLDYYRGYFKAKGLDLAGPHDEAAQSALLESLEQLSQKYPRSAAPRRLALDVAQGEKFRQIAQAYIVKGLERGVPSLFVDVKSIYSDSTKMTVIGEIVQEIISKLEKESTLANDGSIAPPTVLLWAYYYLALHLTHPRNASPNPTRALELVELAITHTPTLPELYMAKAIVLKRAGDPLGAAHEMEKARLLDGQDRFLNGKAAKYWLRAGNVEKAEELLAMFTKKDMSPIQDLTDLQCVWFLQEEGDAYRRSQNRGMALKRYQTVVSVFKEYEDDQYDFHGYCTRRDTFSAYIELLNYEETLRSNPHYAKAALALISIYTEISDNPSLTVEHITPEEEAERKRLAKKAQKAESKAKKAAATSGDKKEEPPLPDEDPKGEKLLKSETPLDDAEKVWKALEQLAGERVETWLAGYEIFSRKKLYAAALRSLLTAQSIAPSNPTLHHQILNFARLTSSADLPAPIAQVIEQSLPTLLGGKDAKSASEAFVEQAIKGSDAEAILGATKGHLEVNHTDVSGAISILSNFASPSVPPSVQGFLSAINFISSREGAEEAQVEALRQKLEERMPLAWALKSGKEQGARKEMLEKEAQGEEVVGKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXZ9</accession>
    <name>A0A1E3IXZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030579.1">
        <property type="nucleotide sequence ID" value="XM_019177426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXZ9"/>
    <dbReference type="GeneID" id="30194552"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN93474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="40483" checksum="7B41F1BF53689FFF" modified="2017-01-18" version="1">MSSDAQATPLQLTPALLGGFQPEKILSESTFTGSTFILGRLEGEDAIVHLQKSLVAGKDAEEVVKRLEDVKLLLENTPYYSAHAWVKPDITHPDYNLKLICPATADHIKKYSIQERYVVRETAEVYETAVKPFIDAMPVSKIQWVYEILEGRKEVDRVLVNKSGPDGFVVLPDLKWDETTQNALYLVVITQDRAIKSLRDLRPSHLPLLRDIQKEAWRVAEEKYGVDKGKLRLFVHYHPTYYHFHVHVVHIRHDNLGSQVAGQAHLLEDLISLLELSPADGPSLLAQKSFTYTLGAEHKLFPVVHAAGAVLGNPELPTDTKPEPNAALVAPVNPSLPTPTAETAPEAVLADETAAPEAKRQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0J8</accession>
    <name>A0A1E3J0J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030706.1">
        <property type="nucleotide sequence ID" value="XM_019177125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0J8"/>
    <dbReference type="GeneID" id="30194239"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="41695" checksum="ECF2986138E540F5" modified="2017-01-18" version="1">MSTQPQYSPPEYSLSALPISRSVKVALEEAGYRTTRDIELMSAEDLSVELAISTSEARFTLQQAEEWQAQIHSATAADLLSTATHPHFSTFSASLDGLIGKFSLSISSEAGSSRKGKERLHTGSIVPGMVVEISGPPGGGKSAIALAVSLSARESGQKERELNGHPEGKAHSEFGEVLIIDTEGAMTTERLYEAARAVVEGDKRLPHDVLQGIHLLRVSTQHEMLALLHTLDEWLESHPKVNLVIIDTLSFHFRQLSLDIAAKRRAMELQVLIALSDSLSICNAADRNLQVIVCNQLATKLLNAENKPANFDTGDRAILMPQLSDSWATSKALRLVVFRGGVSDEIRYVYASMSGLSKTVPYAAFDIDSNGLPCDVPEMLYPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1A5</accession>
    <name>A0A1E3J1A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030922.1">
        <property type="nucleotide sequence ID" value="XM_019176890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1A5"/>
    <dbReference type="GeneID" id="30193996"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1200" mass="127145" checksum="AC4D4731FC794654" modified="2017-01-18" version="1">MSKPKSKTSGPPPLGGQVPSPFRKSSQQNVNAQSSPKFYNGPTVASKPPTAKDKAVVAGTKATAVAKTLQTRTVAKVRRHPWGFVSLLSTIPFLIIISLASTVLCPPPGTSAVNKYLLSPLGYPEHQSHPILCYPANVYNAEVLQPYVYPVLDDLQAKLITSSPYVNYVEPASAQAQRVGVKVWNGPVKPVVTRIQRGIRRFYLTFVEPHIPYLKARYHTFVDPYTTRISALTAPHLASARAYASQAGANAYGTYQYAASHPYTGHASRYAQQGYKVGSQKGFEAYKWSRPHAIRAGEEARRIATQVLGPRAVKAAEIAFAQIDAAWRVVKAQACAQYRTHLEPHVGPHLKTAAAVAAPYYALYNKHIHTPYVQPAYQSVFPPTKEPKTFLKMLADWLPTSGLTAAETRGGLDDYFTDVQKAKKGSTGDLKLGEIKPKKGEKIVKAEAKKPKVEEKSKKDNKRWDRATMNDAIKTFRAKVDEQGKTSEKQVKKELKEHNDGVVQRTIPEFATNMRSEVDKEIEYVLKGLDRLYTQSPTLTREQVKDSSDKADERVGKSLDKIKARLDLVKNRVHGEAKPIVKGQFDVLDTLLGAEYVKLAEHMSWVDDITVKDWDKYHEIRKLASAWKDKYIALHEEPTTFKPFAELRTELSDIHEGFRTRLGILKRTAVDRIEAREEVEAAKKENAKNIKEKKPEPGKASILPVVEGAGAAAAGIAGAGGVIGKGKEQVLSALSAASPTPTAGYAAQAQSSAESILSAASQSVHEATRSAYKAAGGTPSPESPREYAESAYGAVSLAAADVLAQASKSLDAATKSAIRAAGGTASPESPKEHLESVYKAASEGLEALAVGAAGAAHEATRSASRAVGATPTPESIGESYESVVAAASSASQGVVSAAGKQARDASKAAVKAVGGTPSPDSPAEHVESAYHAATDQAASIASDYASSASVLASDASASVHSATRSALSAAGAQPTPESAEEYLESIAGVVQQGAASVYSVAGENVHDATRSVVRAAGGTPTPETPGEHAESLYNAASEGVVDAADAVTEQAARIYTGIQEALGVVSTPTPLASSASSYLASVASEGSSTAAEALATGSSILSSLQSEASVSLHSATRSASSALGATPSPESPGEYKDAAVEQALSARRAAESLVRKHAGQIKRDLEAEGKTFEDYRHDHAAGGVGHNHGHGHEGHAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Z6</accession>
    <name>A0A1E3J1Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031133.1">
        <property type="nucleotide sequence ID" value="XM_019177101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Z6"/>
    <dbReference type="GeneID" id="30194215"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="50199" checksum="F621F8CF32A6D68F" modified="2017-01-18" version="1">MAPTELDRKKLQLQQEIARLSGTHPPPPPPLTPTGAITRHSHSAAHPYHNAPSYAARGGRGRGAARGRGRGRGRGRGASNSYSLDLRATNQGPTATSTATVTGAREEGEILSEPAQSFSSNKWVATNRAESRSLMTAGERAQLHPKSTKPMHNSSKKTRGRLHIQALPSLQAGGTPRVFVDKVSYEFNVGGKGLRRTSEYQIPNTLEWYIENGKTIKVLDVKYKFQPNGDLVPLRPALCPTFTKTGRCRKAHICRSIHDPNRVTACFNFLRGRCELGDVLCPLSHTPTAHNTPSCVRFQALSYCTRPNCPFPHVKVAADAPICEDFAHVGWCDKEEGTCQDLHSWDCPEFWSTGKCSKGKKCRLRHTVRAELGRAQQAAAAAAVENVEKKKANGAKAEPGGFEEQTEFIEFDEGAPAMPQSDDDDSDHDSDDDESDGKQEVSADDSESDSDDDDVKIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J245</accession>
    <name>A0A1E3J245_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031014.1">
        <property type="nucleotide sequence ID" value="XM_019176982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J245"/>
    <dbReference type="GeneID" id="30194092"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="233"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="42726" checksum="04A905A4E46AE712" modified="2017-01-18" version="1">MVTLFSRLAVEPHPTESATFIPRNPALWLPPGVRSVYGGLIIGLALQSARRTVPAHLGLQSTHCYFLRPGVAGHEMKYVVSTLQDGKAFMRREVKGWQKGKLFFVLMASFTVAPEVLPERIFKRGDVRKEEETPSKVSNSLTDMSQPWYEDPSGRNGEGRRVKEGFQVPFPGDILLPYDQCESNESFIARRLEATWDVPQWKRDFLTTWIEQRATSPFLSAVARLKPGVTCPPEFFVDGNAATRMTWNRPTTTADEVIDEEAFKAMIAFISDYQLVGATTRAMGINMSTTPHVTMIASLDHSVHYYPFPPDLDYRKPTLHVMEAQVGDFSTARATARGRVYSHDGVLLAVTCQEGAIAWKGDGEPRRGLAASGVDEEDLMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Q6</accession>
    <name>A0A1E3J2Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031143.1">
        <property type="nucleotide sequence ID" value="XM_019176668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Q6"/>
    <dbReference type="GeneID" id="30193763"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="92" mass="11037" checksum="F4BD10F988D5F2AA" modified="2017-01-18" version="1">MVYTIVVHLQSLPEAVQEIKAKLKEASEIYQKDKETIDWYVMQDPKDETKFCIVERYEQESSQQYHLNNPTFDPYVVPRLAKPMDLTRWEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2W5</accession>
    <name>A0A1E3J2W5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter, SP family, general alpha glucoside:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031169.1">
        <property type="nucleotide sequence ID" value="XM_019176694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2W5"/>
    <dbReference type="GeneID" id="30193789"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="65"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="561" mass="62373" checksum="1A9F1DF042D5F96A" modified="2017-01-18" version="1">MAPPEHDEIIKTSSIPARKVSVDGPLYSQDKAIATMYANAQAATDKEQNMTLREGIRKYPKAILWSILIASCCAMEGYDISLLGNFYAFAPFNKKFGVELADGTYQVPARWQTGLSNGAQCGQIIGLILNGIFTERFGYRKVLMVSLSWLIVVITMFFCAPNIKVLLGAEILAGIPWGVFQSIAISYASDVCPVALRGYLTCYSNFCWGYGQLIGIGVIRAMFKRDDQWAYRIPYAVQWVWPPLILLGVIFAPESPWWLVRHGHMERAKKSLRRLASPKHNPDFDEDEALDMIRHTTELEKDIASGASFLDCFKGVELRRTEIVCVIWMTQNLAGNVFSNYSTYFFEQAGLTGTIPYDFAMGQYGINMVGVFGAWGLMALGIGRRKLILCGFSGLFVTLITMGFLGLVPESHKTQGAMATGSLMLVWAVFYQCTVGTVAFSLVGEIASRRLSIKTVALGRAAYNVVAIICNVLSPYMINPTAWDWGNYAGFFWAGTCLGCLIYSYFRVPEPAGRTFAEIDILFERGISARKFASTPVNAFDVSLHHAVEDYKEVTQHVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J326</accession>
    <name>A0A1E3J326_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030892.1">
        <property type="nucleotide sequence ID" value="XM_019177311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J326"/>
    <dbReference type="GeneID" id="30194433"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="113"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="244" mass="26073" checksum="F8D3390363169C62" modified="2017-01-18" version="1">MASSATNNGYPVLASSLEPYLPNTHGGHGTDDQAHSIDGIEESDSGRTLHHNSRGGLSDENKLGVFQSSRAGDFQSPEGKAANNLGPAEGTAAAAAPQGQKPMKKFAYSCATVIIATIVIWLCLPVYWGSLWKANKYTDKLTVLIVNCDSGTVGNTVTSTLLNLTNLNYFTTPASEFATNEDVANDVIEEGVWAAIVINEGVSDRLVSARQNGLSTWCGSGTIEVYYAQRRQETAINSYMLPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J6</accession>
    <name>A0A1E3J4J6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CAMK/CAMKL/PASK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031432.1">
        <property type="nucleotide sequence ID" value="XM_019176504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J6"/>
    <dbReference type="GeneID" id="30193598"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001062">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000747">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="782"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123307" checksum="C4A36F54A56FAE1A" modified="2017-01-18" version="1">MVVTAISPVHPNHADAADALKTALSPISPKHPPPTLDYGLPGTTPPDRMSPTVVTSSPTVSGIPGRDESAAGPSSPRPIPPPPNARRHRSGILMSRVRASGSATRLQGDVSGSKSHGDLVSMAAARRDDDEPENGDVMEHLGQDTDEDDDDFWEGYEGRGRFRPASREGWKRVMSEGRHNSDGESFWDNSARYYHHLHSGRNSQSPSICTSPDQSPVASHTTSPIFVRRNLSLPQNGSAGVSGSAKSLSPNQHFLQSHLPPTFPSPVNSGTSPDTLYPEYQGPAAMVFTPTTQEWKDLQETPEWIEAHGERVDANFASSDEDDSGHSRHHSLEKDEGERPRRILKKSISAEYLGPEETHTPDPGSPPSGDKSAPLAPVYQPNIIAPSPVMAANLSRRCSAPLTLGSPAAESPGLPDGVQSTGALGLKDTSACPTSPVNQSTPTPGEADPDDVILNPNRGAAPARWNSIGRRDSLRSVTEKEAPPPLQRAKTKRELEREKLLKMVDEELEAEHEPAQSPGWGGGVQSIGKGFSLDSARSPGTPPPSDVPTVRVDPDALNGPSSEDPAVSNKKSPPNPFESHFTKKLGSKQLTSPFKPSPLNASPIVAPEDGSVTPSTAATTPAADVTLEATTQFNTRPTTESSSETSTGLDSIRDYTRGIAGSQPPKPGDITPPKSPRVSSRKRDTNRVSLVAGRVVRPFALPPSTALPPSARAAAESPALQSFSPFISPNTAPSTPATTTFPRLDSHISTISTAPSTGVPSECGTPTEEKAAGIGGRGIDDYVILKEAGKGAYGLVMRAKVKGLNGQPVGDEVIIKYIIKARILADCWKKHKTLGPIPVEIHVMDQLRQLIYTPPKTMNPWDPARPRPGQFKPPFDSADSLSSTPVSPGKKDQLSPPLSTVQKHITDEIKTSPRRGHPNICKLVDFFEDREFYYLVMPRFGTGLDLFDRVETRPLGLDAFEIRSLAGQLIDAVNFLHINGIVHRDIKDENVILDGSGHCQLIDFGSAAHWRPGKKWDTFSGTLHYASPEILRGDMYGGKEQDVWALGVVFYVLLVAETPFSEIPDEVLKGLEEGYQADTVLMARCGNGHEEEGLEDDGGGRLGDAADLVRRCMEIDAANRPGAETLLKHRYLKGAGGWTGRKGWIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Y8</accession>
    <name>A0A1E3J6Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031366.1">
        <property type="nucleotide sequence ID" value="XM_019176438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Y8"/>
    <dbReference type="GeneID" id="30193532"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="252" mass="26598" checksum="3C6DB0250DF98E9B" modified="2017-01-18" version="1">MSDPKLPHDATFDRTITNDRASVTASANGGGYRGGEGFRRVVTPGGSPEDNSQPAFPVFHRKFGNPAPLGLLSFAATTFLLSLLNIGTRGITVHNVILGMAMGYGGLSQIIVGIEEWACGNTFGATAFCSYGGFWISFGILYIPQFAVLESYTDPTMLDDALGLYLVTWALVTVVFVLASLRSSIALISVFVCLDITFWLLAAGYLAPSTKCTTAGGAFGIMTAAAAAYTALAGMLTKDTSYFLLPIGDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7B9</accession>
    <name>A0A1E3J7B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031496.1">
        <property type="nucleotide sequence ID" value="XM_019176568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7B9"/>
    <dbReference type="GeneID" id="30193662"/>
    <dbReference type="OrthoDB" id="3256826at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="42398" checksum="8F65450AFCDCDBAB" modified="2017-01-18" version="1">MPFGVISYGEGALLFTCVLNALAIELYAFTRFARPADNGQIAREYLAVAAILRAKRLESSGHVSDTLQRGYHSHDTEACTVLYRDGQGVDTSIPTRFARSIAAAKYSLAICPSSAGLANLVKAYNSIANAFKAQVNNNAPSPYEITPNGIGFYNTKLEFRSKVFMFANRKNDASLRLYTLPLYSLTWCYHQYTGENFPCDSDLEEPVVTAMLKGTAYRRRPWPRVVVRGPSVDPESSDAEAIFEAGFHSLVYLPDDVVLSVAFNVEGYVMDGKRAGLEWTPSTIIVHGRVSAGNTTESSPAKRPRQDALSSNVLLGKSPVKKTKSSSMPSESPVASNSSSAASNSYAGPSSSSTAPSSSAVTSSDVFGGTEPLRKSSRSRKGKEREDDDYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J908</accession>
    <name>A0A1E3J908_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 12, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031939.1">
        <property type="nucleotide sequence ID" value="XM_019176026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J908"/>
    <dbReference type="GeneID" id="30193113"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15573" checksum="0BDCD5E9445DB67A" modified="2017-01-18" version="1">MVRGQGGVINGSPVLRGYGQEPPERMEVHRGGVQKQGQGNWLHRGGSLIFEFAALAPDYRLRSILADEDPSARFPNQNQTKHCWQNFVDYHKCVNAKGEEFAPCQQFKKAYRALCPNEWVGKWDEQIEAGTFPASLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBQ5</accession>
    <name>A0A1E3JBQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032172.1">
        <property type="nucleotide sequence ID" value="XM_019175682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBQ5"/>
    <dbReference type="GeneID" id="30192767"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29112" checksum="25862986FF28B4DD" modified="2017-01-18" version="1">MSWGGFKKAATRAGTSIMQKTGQVERTVDREFAEEEGRFKTMEKETNNLQKEAKAYLDSMRSMASAQSRIAETVSLFYSTDRTSDGAMSAHSYKSAVDELDSGVGRDLDSPFRATVLDPIGKLNSYYPNINNAITKRSHKLQDYDAARSRVKKLVEKPADDTTKLPRAQAEHDEARDIFNLLNDNLISELPVLVDMRVPFLDPSFEAMIRCQLNFATEGYERLSGVQRQVTSSPNYANGALDTQVESVLEEMKELSIYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBT1</accession>
    <name>A0A1E3JBT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 38 (Sodium-coupled neutral amino acid transporter), member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032195.1">
        <property type="nucleotide sequence ID" value="XM_019175705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBT1"/>
    <dbReference type="GeneID" id="30192790"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="61"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="465" mass="49905" checksum="7743F7B2162AB2F5" modified="2017-01-18" version="1">MSGKKSVDTRTVFRAPEEDLEMEDSVSAPLLAGGPSRRNSAITSEQLDLLEIEGPNSASRGGLMEAVTNMANSIIGAGIIGLPYAVAEAGFVMGIFLIIAIAVISDWTIRLVILTSKLSGKTSYTETMDHCFGPLGGYSVSFFQFIFAFGGTAAFHVIIGDTIPRVISYIFPTLSEHAILGLLVNRQVVICLCTVFISLPLSLHRDIVKLSKSSGFALLSMGVIVFSVLFRSVAVDVSLRGSSLDTFSLVKPGVFQAIGVISFAYACHHNSNYIYRSIHVPTLDRFNTVTHISTGVSLIACLLVAVTGYVTFTDKTQGNILNNFAEDDWLINIARFCFGANMSTTIPLEVFVCREVIDESFYKGKSFSQTRHVLVTCAIVFSTMLLALTTCDLGIVLELSGGLAASALAFILPAGAYFTLLFGPWTSRKKLPAAIIAAFGVIVLVLSCGLTLKHAWNGEGGKTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU0</accession>
    <name>A0A1E3JBU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032210.1">
        <property type="nucleotide sequence ID" value="XM_019175720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU0"/>
    <dbReference type="GeneID" id="30192805"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="672"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="831" mass="87694" checksum="54119DD06EB66DE7" modified="2017-01-18" version="1">MSVHSTPPHPSSGRSTASPPQFESSEAYLSLIARVSRTESQLGALSTQVAQLSDLVRSALPNRSGFAPPEPPKRPVFSPFDSDPALEAGGGASNTGFPGHHQPKPSPHIPSATTPSALTNNENPPQDASISALTQQISALSTSVAQLQRLQHTQTQRQPSFPPPTQSVQPQQLGSSSLAGDRHPGPLSLGVPPRHPGGIDTGPLTMPSTQLPLSFGGLSPTRPNMNRSISSSVVQPEFQRHGHSHSHGHGPLGHHAHGQHGSSALARDSMARDWPSPGPGGMQTPGGQGRDGLLTPGGAPGGGIVISKWEHLNLKVDLLRSISKYGIGPPNKIQTRVLPFMIKGSDIIAQAPPTTERIISYVIPALHLCQSLLQPTGPYAGPSVIIITTTVDQAMQCHKLVRGVGGPIGIRAGIAAGASGSSNLQNEIAQMQREQIHLLVGTPAKVNEVMGVRGGLQGDDTRLLIAMDQLIARNLYEHVLNVSKLLPPPRGRGGALTPGGPIPFSPGLTSPYDAGRDSPFNPASKTPFPNANGAQGGASRFGAPGQSPAPPSVSNGGPGGVDRQTCLFSNTIPTDVINFSQSLQVRDPVRVLVRREGGNNSQESVSSVTPGVNLKHTYVYLTITGSAQNGNNAQAEVGPGTIGSGRSQGGPGQMNEEQTRAKEYKLNMLVKMLDDYPLWQAIIHVGSFAILEAVIWKLKSRNWEALYLTPDMSQQQKKAILQQWRLSLSGNGPRFLVVCDVNIKPPEVPWSPLVINFDLPRSVEGYAQRAAAAVPPSGGGGRQGQQGAVNGVIVSFVQAAGGDVEMLRSTECAYRFKSAEIPTVFHDLFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC65</accession>
    <name>A0A1E3JC65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032127.1">
        <property type="nucleotide sequence ID" value="XM_019175637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC65"/>
    <dbReference type="GeneID" id="30192721"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="39739" checksum="3737FAE69FB07BDA" modified="2017-01-18" version="1">MPNIVAITGINGFIATQVVLLFLTRNWHVRGSVRTPLQAQSMKEHPVYKEWVEGGKLEVAVVPDMAGREGEGGEVEGLLDGVRGVVCLAAPLPGADTTSWPGFRDPTIQGIKRVLEYAQKSSTIKSVVIMSSVAGAVDWSAPPGKVFTEDDWIPFSDDDCQADGADINPGILMKWYGTAKKMTEQYALEFQEKEKLGFSIATVAPSMVYGPPIYIPTASDLPKLQYYQQEFFSLFAGGKDRKLPEQMAQSWVDVRDVAEAFYVLVEREGRGRYLISGGEYKWQEWADKLHTLRPDLDEHLALGEPGKYPDSRWKVDGSKSVRELGMKYRTAEETLKDTLAYFEKIGVFEEAAGAWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC87</accession>
    <name>A0A1E3JC87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032316.1">
        <property type="nucleotide sequence ID" value="XM_019175826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC87"/>
    <dbReference type="GeneID" id="30192912"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="318"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="528" mass="56990" checksum="A95985086D081BA5" modified="2017-01-18" version="1">MASPPVPPLRHAVTQPQTKLEDDQVVHNTNIRPVQSRREVDPFPLHLARSLSRSQSQNAPSLHRPLTRHDGLDNIPPPLPASPQQLERMLSGNPDLERQMGVNDEDVGPPPEGGMEAWCCVGAAFMVLFCIFGFVTSFGQLKSYYLENQLSDYSQSDVAWIGTLQSFLTFAGSIASGRYFDSHGARTITIVGTSLNVGATIALAFCKEYYQLICAHALFGLSGTIMYSPSTAVSGHWFMRKRSTAVGIVVCGAGAGGIIYPIALKKLFEKLSFRDSILIIAGMNAVLMFPAWFFLKARLPPRQPPPYRNMRRPWKEARYTCLVAGSALVMMNVFSPYFNAPILFNSNNLSPELADYSIAILQAGSMIGRAMSGALADLFGVWTVFLCSILGSSISVYAFWVPPSINAATAVVGLVAYGAFSGAWIALVAASCGAISPTREFGMRLGMLWSTTSILALAGPVICGLLITSNGGKFEHAGLFVGSTHLVGAGLTVAPRFLEILRDGYRQLGGKSGESYIIKETKERSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCF0</accession>
    <name>A0A1E3JCF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032412.1">
        <property type="nucleotide sequence ID" value="XM_019175922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCF0"/>
    <dbReference type="GeneID" id="30193009"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN98550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="86" mass="9180" checksum="91000F322B4CDB86" modified="2017-01-18" version="1">MSTVTTNSMAISCQEAVPGIWSNIIGPTHISKVPVLDGATMLPQLIPYPKSLSVNIFPNSPKQSGHYYTTGQTECPADITAWGMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF26</accession>
    <name>A0A1E3JF26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032560.1">
        <property type="nucleotide sequence ID" value="XM_019175457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF26"/>
    <dbReference type="GeneID" id="30192540"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="376"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="69533" checksum="5C19F0754D0374F3" modified="2017-01-18" version="1">MPRKVPISNKRRKEQLLVKRALKRGDMTAEEHDQLRSQQKLKTEKKRPGQVAARSDAPVDASSRKLQSKFIALSSDYVVRTRELAYALPLERPLPASSAEFPLGVLEDRDPERRLTCPARPKFRYGQTKKEVEKNEEGVFKKWLKGVEEVVQEYVDGEEEQVETEDETFNLPRGPTWFETNLDVWRVTESSQVLLLLMDTRCPPLHCPPSLRTHLQSLSPNKEIILVLTKSDLVDAKALQGWKQWVKGWWGQEGVQVVSVRSYDIELLREGKGRHKPDIPQQSLDELISALRAAHERLLQPPARVRDDPEKLKSWKAPTRPTVDWAALTEESEVVLSLKKEKMQVAAEVAQEADESEAETSGEGYRRDLATEPFTLGLIGQPNVGKSSLLNALLGEQKVRASRQPGKTKHFQTMFWGSKKEVKIVDCPGLVCPSLAGLEVQALAGIIPISQIPSLPSCLTFASSHLPIETIFKRARKRDEERKHRWSVGGVLEERAIDKGFMTAKGGRPDINRAADGMMRALADGKVRWGFYPPKTSGKEGAGIWLGDDVDEAGAADGPSAEEETAEEDEDEDVEDGESQSDEEELSGSEEDDKMPMKQAGGFFAALEISEDEEDESEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF43</accession>
    <name>A0A1E3JF43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032577.1">
        <property type="nucleotide sequence ID" value="XM_019175474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF43"/>
    <dbReference type="GeneID" id="30192557"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30402" checksum="A5B92F1484031979" modified="2017-01-18" version="1">MNLPSNGESSRPYAYYSPPQPQDNNAVFEAFEAYSFNDDPEFRAGLPAVISAIRGQKMNPASIDEMLSRAQWFYFTRKRNVQIPWEAYVHYSRQPHSSPPRQIIPREGLRQLDSLAEARRMMSATCNVGNEGMSFEMLVRLIHEGRADEVPREDVPDGIHDGPPSQATMAHRPKPWESQTLLPDTSLTHSFFQPTPPSNTNTCSTPSTSGTASADPNAETTGLAYHGGVFDLTGMQGYGEISEEDLAMILGGEHNVDRAEGESKTDGWSWLQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF84</accession>
    <name>A0A1E3JF84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase UHRF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032606.1">
        <property type="nucleotide sequence ID" value="XM_019175503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF84"/>
    <dbReference type="GeneID" id="30192586"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="146"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN99529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="35828" checksum="5430B8A8ED6D3A2D" modified="2017-01-18" version="1">MTLSYEQQRLQNIKDNEDLLKSLGLSSVAPAAPKTPKATNTKPTPSKSKKNVTPGSAVVRQAANGSSSQNTTPAPQEDSGNRRRSLRTGGKNRPNYLKEQVSGSYSGSLDGSPSKRSFVDDGDDDDDRQRKAQKLGVRLHDPKTFGQIPNVEVGRWWSSRMEASTDAIHAPTVAGISGNAKDGAWSVALSGGYPDDIDLGYAFTYTGCGGRDLKGTKQNPKNLRTAPQTSHQSFDNPLNAALKRSVQSKKPVRVVRGYKLQSKYAPVTGYRYDGLYIVEKGWMSKGLTNGLMVCRYAFKRMDGQPPLPENDLGKDADEADSSEVPDKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JH43</accession>
    <name>A0A1E3JH43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">L198_03268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032503.1">
        <property type="nucleotide sequence ID" value="XM_019175400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JH43"/>
    <dbReference type="GeneID" id="30192481"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="173"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN99426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="39330" checksum="C15224C0BBD2176C" modified="2017-01-18" version="1">MPAQPSIRAYFAKPHAAATARVALKSTSPPTARQGTENMPVNESSEAGRVIAKESKKRTRSGETAAAAASTTKVAKVTASATSTIPSKTAASGKFDSVADVREAVRGTSLPLLELETKSMGEDWFLALQQEFTKPYFLKLKEFVTTEQRTKKVFPPGMSRDEYTRQDIYSWSTLCPLKDVRVVIIGQDPYHDDGQAHGLAFSVRQGVKIPPSLRNIYKEMTNEIPGWVSPTHGDLTEWAKHGVLLLNTSLTVRAHTAGSHSKAGWDQFTAAVLKVVTDRLAPTSGEGSGANGVVFMAWGAHAAKMCAGVDSKKHLILKSAHPSPLSASRGYFGNNHFNLANEWLEERYGAGGGIDWKALGAAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI25</accession>
    <name>A0A1E3JI25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032722.1">
        <property type="nucleotide sequence ID" value="XM_019174990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI25"/>
    <dbReference type="GeneID" id="30192062"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="42069" checksum="4516F7100680370F" modified="2017-01-18" version="1">MSTYHAVILGAGVLGLSIAHELTKKGLKVAVVAKDLPEDLDSTGFASPWAGANWHSVASKDNIPEQERDRYTFHQFERLARQVPHLCERRPYRYYWNEDDDGGWGECWYKDLVFGFRTLTPSELPPNFKHGVTYESYTLNTPLYLTHLASTLRALSVPIIRHRLSSLSEAYSLPALGPVELVINATGLGALSLLGVEDPKVFPARGQTILARAPWVHVCYGLNGNISPAWQRVYIIPRPGPDGHVILGGVYRPHDWSTGPEPAVAERILQETWKVCPELDGKGGKGSWEDIEIVSHNVGLRPCREGGLRLELERFTLGEGVKQGLETVKGKNSKASLEGRGRKVGVVHAYGIGMAGYQSSLGVAKEAGEKVVEYLKGSGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIN8</accession>
    <name>A0A1E3JIN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032910.1">
        <property type="nucleotide sequence ID" value="XM_019175178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIN8"/>
    <dbReference type="GeneID" id="30192257"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="66"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="226"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="744" mass="80401" checksum="4AF3702CF158980A" modified="2017-01-18" version="1">MQKDYLKRTQPEPTASASAEASSPVPPSPVSPNTVTWTNKYLPSRKSTTASVVDNSGQEVGDDRIILYIHGGAFFFSSLETHRYQVQRHARKAGARAFSPAYRLSPQYPFPCGLLDCLASYLYLISPPPSAPHKPILPTNIIFMGDSAGAGMCVSLLVLIREMGLPMPAGASLISPWVDLTHSMPSIGGWDGGDFIPSSGFHYKPSCAWPPLPGSGIDITMADGSTKRVDEQVQMYCPNDLLTHPLVSPVNQGSLGGLCPLLILGGGAELLRDEIVYLAHKAADPERYPPSSSTLAEYPDQVPKITKYKPTKVHLQIYEGCCHVVPTMSWTKSSKYMYRACANFNIWAFNAAHKALEKKLQHKESSKSIKKSRSSASLKKTALANGLSSLTIPDSSNGGPQSAHSSKSSPTNFTTSPTNLAPSPINTTSPLVNSASPTPPSPAISNSSSQQNTLDLTQPIITSSAASAANGKPISFNEAQSEAESEEEDDDSSSDDGDDTDEESGADKGPRTGVVTVNGTEPLFGNVNIVPERVSTHGNIRPFEDIAAVPALQPGLREHIGRVHGEGAVQKWLNKRADWDKKYSRDLAKWRKLRSEDRAKAEKDGFLTRDLQGENPPMCAVAGLWDEKLAGDVARSVDEVYARSAALGWWTKWGSKADKEHAEKHELREIKSRAEEESKLRTQSLDDLPSSSTSTPTLITPPAVGSYGKFGSREGSRGQLFVEPEAILEDADGEEVHETEAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIQ2</accession>
    <name>A0A1E3JIQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine13 synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032971.1">
        <property type="nucleotide sequence ID" value="XM_019175239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIQ2"/>
    <dbReference type="GeneID" id="30192319"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000015">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000016">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.23, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="529"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="881" mass="98094" checksum="F1224F88224F6F39" modified="2017-01-18" version="1">MSAPENAHKRPAEDPAAHDEAKRSKMDDTAGVETPESVALASTSAPAQAEAPAGEPIPSNQPSYTDHLHASHRRLPDPVSKLGLKPTHWDLPPSLKLITGLDPDMVARKGFVGEEECGIRGFVGKGKGVRGVIKQRFTDFLVNEIGLDGEVVRLKNIIKPEDPSVPSKENKGKKVASEEDALNAEAGEAEEDKEEDLPENLRLSEHPSWPKGTTTTLRAHFSDETIIALHALVLQGRNAPPKGDSGWGARKPKEGEASADELKEQETPEEAAMNQASGSGRGRGQGRDRGRGRDGGRGGRGGRGGRAGDRNADSGSWWLAYEDEREIVSQPINSKEERTACHKILREVFPNMFESSTKEVKGEDSQRLAIKWSSGQQKTGYGKGQRRGADQPKLGPYIHFTLHKSNRETMDALNHIQRLLGCQPKDLTVCGTKDKRAVTVQRVCFKRTGRSLVTAWRSLNGIRQGWRTEKQALEERGDRGVRVGDFEYSDKYLELGMLKGNRFMITLRNVEAESVEEIDRTMASVRDMGFINFYGMQRFGTSSVPTHITGLFILKGEWSSAIESLLSLREGEHPDCVEARLLWLEDGDYVKALEKMPRRAVAERSIWEFWKKGNRMEDKTGALGSIPRNLRTMYVHAYQSYVWNLIVSERIKLSATEPLVGDLVIEKTEEEDDPENVPAHRKDRWGRARTWKTSSSPVVKRLTEEDIKNKTHTIFDVVMPLPGFDVDYPGGDIGELYDKMLKADGLDKDRMRQYSLSGSYRVILLRPLALTWSHIQYTDPDVPLVQSDEDAILDLNVPATHDPAGKFRAVKVDLSLGSSTYATMVLREITREETSSWFQRGRTMKGEDQEFKGSKKVEGEEGGEEDAAADDGEDEMAAMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW3</accession>
    <name>A0A1E3JIW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033016.1">
        <property type="nucleotide sequence ID" value="XM_019175284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW3"/>
    <dbReference type="GeneID" id="30192364"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="58"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="35944" checksum="7DE9CBE76170DEE3" modified="2017-01-18" version="1">MLARSALLRACPLSAPARTLPIAHLRAMSTSPEAPIVPTDPSAVSSPLGEGKFIQTAGCLIIGDEVLNGKTKDSNSNFFAQYCFDLGIDLKRIEVIADDQDEIVEAARRMTEKYDFVITSGGIGPTHDDITYASLAKAFNLPLVHHPETLRRMWALTTPERRKELEAASQAQREARERMALFPTWKKEGDAKSEAIFVEADKWVPVVRLGGKLCVFPGIPSLFQQLLLALTPYLPLPPASSKPFRHLIYTRQPESAIAPYLTELQARVKKEGIRIGSYPYLYQGVHVSLIGHDVDRIRSLGEEVIKELDGKVVSEGKLGDESGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKN3</accession>
    <name>A0A1E3JKN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032869.1">
        <property type="nucleotide sequence ID" value="XM_019175137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKN3"/>
    <dbReference type="GeneID" id="30192215"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130417" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="502"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO00677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="774" mass="80847" checksum="6DA9E3F00B12757E" modified="2017-01-18" version="1">MYYSTAILSLLALVEAAGPHHGSNRLHRRHHARAALSGGSVAPPPLPVNLHVEAPAKRDDDSCTHGDWNCVGSDLQRCVWGDWTSIRNCTGDNIVCSTQDNAIGCVWTWNVDSSATPTSGAESATASLATVTGSLEYNATSALSASEASATASQVANSTLTGAIAAASPTTTGYASNVTSTNSTTTDEDDEDCDEDEDEGEDEEDENKDCDDDDEDYTSTSSVVAASSSVASQSSASSDIGNAAAYATAEVSSSPTASSSSASASASGSSEDDDDEDSDYDEDEDDEDDSDDDDEDDDEEEDDENCDDEDDEVSSSSASVSASAPVSSSFNSSVPPITASATSSASFANETDSASTANATETPAIGDGLYAPGQDSTSSSASETAWDTASSSSSETHWWNSWNTKSSSASEASATASGSESTSSTDSWSSDPTASSSSSDADSWNWWGSSSSNTKHHKSSTTDSASTASASQSSSAATASASSSASSNTSSNNTSSTTWSAPHYVIYADEYLSEMPSASELSSYNRFILAFWQYDGGAVDDVQTWADFDESYRNEVITEYHNAGIALMISAFGSEDTPTTSGADAKTVAQDLAAFVQEYNLDGVDIDYEDMSAMNSAKAAAWIITLQTELRSLLPSPYIISHAPVAPWFTSASDYSDGSYVTVHQSVGDTIDFYSVQYYNQGDDQYVSCDTLITNSGSEWPSTSVFELNSYSGIPLEKIVIGKPLDSSAADNGFMSAADLAVCVAEAIAKGWNGGVMFWEWTSQAPSVMATVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLZ8</accession>
    <name>A0A1E3JLZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase GET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033137.1">
        <property type="nucleotide sequence ID" value="XM_019174758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLZ8"/>
    <dbReference type="GeneID" id="30191827"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="329" mass="36407" checksum="8D4C40DAAEB91E37" modified="2017-01-18" version="1">MSDDLESLPPTLQNIIDQQSLKWIFCGGKGGVGKTTTSCSLAVQLAQHRESVLLISTDPAHNLSDAFSQKFGKDATKVNGFDNLYAMEIDPNGSLQEMIENSDQSGGGMGGMMQDLAFAIPGVDEAMGFAEIMKHVKSMEFSTIVFDTAPTGHTLRFLSFPSVLEKALGKLSSLSGKFGPMINQMQSMFGGGAAGGTDDMFAKLEGMREIITEVNNQFKDPEKTTFVCICISEFLSLYETERLIQELTSYQIDTHNIVVNQLLYPKPGDNCEQCSVRQKMQKKYLGEAYELYEGEFHIVELPLLTEEVRGVEKIKKFSKMLLEPYTPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM21</accession>
    <name>A0A1E3JM21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033152.1">
        <property type="nucleotide sequence ID" value="XM_019174773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM21"/>
    <dbReference type="GeneID" id="30191842"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="262" mass="30000" checksum="A9E63568ACA621F2" modified="2017-01-18" version="1">MFRRQVCARKGCGTGVKTFSTSAMRSARQKDHYETLSVQRNATKQQVKAKFYELSKKYHPDASEGDVARFHEINDAYSILGDESKRRQYDQSSSTVSSHRPFQSQSYANGHGHSSFRPHDPHLHRAAQGPHRSWNSSSYAHHPFSKPRTETYSPFGRRTPEGYAYAHQYNYSFNPNLRTTERTNQGWGRRKPTHAQSKEEHVHSSGGGIWRFVITVGMILTVISLGGGLTATESKVDWNKVWSEREGKKMGRERKRLKEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM89</accession>
    <name>A0A1E3JM89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033241.1">
        <property type="nucleotide sequence ID" value="XM_019174862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM89"/>
    <dbReference type="GeneID" id="30191933"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15159" checksum="8BD2D7F7009752FE" modified="2017-01-18" version="1">MPVRIRFARHGHRKNPIFHLVAINSRRPRNGKPLELLGVYDPIPRIRDTLPPPPAANVFAKGTEEMIKKEKKAELNVERIKWWLGVGAEPTRSVVKLLERGGVLTTPHKWQHMWSPPPPGAGQSLPSATSSAETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRE6</accession>
    <name>A0A1E3JRE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">L198_02287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033491.1">
        <property type="nucleotide sequence ID" value="XM_019174439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRE6"/>
    <dbReference type="GeneID" id="30191500"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="23676" checksum="D070322BFF8AD2CD" modified="2017-01-18" version="1">MPGLLVLLIALTSLPILFALRVYRLLPSRATKAQSRAGGHTSEMKALLSSLDFERYQPRTYIYCHGDNMSLNAVAEIESQKGSLTHAKAYDLLPLPRARRVGQPALSTSISVIKTLIVTVHHLLVVPLFTRPTEPFADLLIVNGPGTCVVLVVVAWIRRILGLSYTKIIYVESFARVKSLSMSGKLVRPFVDRFLVQWPQASDHKAECKGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRF1</accession>
    <name>A0A1E3JRF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hormone-sensitive lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033510.1">
        <property type="nucleotide sequence ID" value="XM_019174458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRF1"/>
    <dbReference type="GeneID" id="30191519"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130506" evidence="3">
        <location>
            <begin position="35"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="262"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO03459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114013" checksum="4489688532A94682" modified="2017-01-18" version="1">MIDQILGRPSPTLRRSQIWLILFFWVWRLYKGDGAPRPLGRNPASAFIPGSSRVSGGIGERVRDRAAKSWLWKLWVELLGRRLVTWMGKVNDRLRIFTPYQLILATLTVVYAVRHVDDLLGISAPEPLAKLYSRSYYRATYVNTALDAGFSMAMNIKPQWLKDISSMVFSGYYLLYAREGDEVLRRFRAVCSVEMLRTTWDKTNNPYIRLLTARHRPKLPIVRTIFIPRPSQSSRASLPPVKTMLFFSGSEAELAQATELIVDFPGGGFIAMSPECHEERLRTWARRTGKPVLGVNYGKAPEYPYPWSIEEGFDAYRTLIETKGNVIGIASGRLDIVLSGDSAGGNICATIMLRIIEYPTHIPRPISLVLAYPALDFNFTSWMSPQNLSVLRTEQSETQIPGMIHGKDHMRHKAPLSVVDDVEKKSRRQKTWAATISNKIPMMSPRTEGWRSNPQSPKSPSKRLADLPRSVSAKVMAWATADAEEDVRYSTEEEDEGDEGDEKTDSKVVGGADKRKDTEKSLADRVKTPREENRFELTRTESPAPMVEAEKDKEAFDAKVEKKRKKKGAIGTRLTMTSRVGYFQDRIISPTMMRAMAILYIGPQRNPDFETDYYISPILAPPHLLTHFPPVYLICGERDPFVDDTVIFSGKIRSAKRARKAEAETAALGKSTKHGEGLRMSTSKSKARREDTVDPILQETDEDWVQTRIIEGWGHGFMQMSSLMKEVDPVLLEMADWIDESFLREKERKREAEELSAAARLSASTYPTVEAGVTAHASTSLHLKPTQDYPRVPKKTGTADLGSAYFGAVEAPEDANDNLVTFTPKNKKRTPPPSGFLPVPRRASKESLASLRRSPSAPKFDADETGSSGEAMSIVTPPLSLKSLPFREGATRGKATFGLFGGTTTPAKPQERSGRVSPTLFGRPRERPGSSNASKPIPSPSAGARTSSVPPHSSLNSSTPTSPPEKPKGGLVAAALSSARAASPALAAAAGFVPQSVGHVSEAELMRRRRMEAVYGIGATASGASSEGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRS4</accession>
    <name>A0A1E3JRS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP-2 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033427.1">
        <property type="nucleotide sequence ID" value="XM_019174375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRS4"/>
    <dbReference type="GeneID" id="30191435"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO03376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="432" mass="48895" checksum="448AB954876E419A" modified="2017-01-18" version="1">MISAFFIFNQKGEVLISRLFRPDVKRSISDVFRIQVISNPDVRSPIITLGSTSFLHVRINNVYIVGVTKCNASAALVFEFLYRFITVARSYFGKLDEESVKNNFVLIYELLDENIDFGFPQNSEIDTLKMYITTESIKSEMAVREDSSKITIQATGATSWRRSDVKYRKNEAFVDVIETVNLLMSKEGTVLRADVDGQILMRAYLSGTPECKFGLNDKLVLQKRGGEQIAKSADAAVELDDCQFHQCVRLGKFDTDRSISFIPPDGEFELMRYRSTSNINLPFRLQTHVVEVSKSRVEYTIHLRAAFDSKLNANNVVLKIPTPLNTTGVRNKVGVGKAKYVPGENFIVWKIPRLQGAQECTLTAEADLAATTHRQAWSRPPIQLDFSVVMFTSSGLLVRFLKVFEKSGYQSVKWVRYLTKANGSYQIRVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRX2</accession>
    <name>A0A1E3JRX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033682.1">
        <property type="nucleotide sequence ID" value="XM_019174630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRX2"/>
    <dbReference type="GeneID" id="30191695"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="956"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115014" checksum="74169FAD5BD9951F" modified="2017-01-18" version="1">MPNSSRPPASSAYPPLSHDAPQIPPFPQLLYIKNESHSTPEPLTAMTDSHDHMVMSPDEDDDGHDSRGGSPPPLEKKRKTTNTRRRVVQSCSECRRRKIRCDKKFPCGPCILRNEQSRCHEVGLADKTPTLPPNGGSWASSADIGHVNDRLDALEASLLKSGALRREDLNYFLTTISETDALTGRKKTKIEDLIDDTEGAALTLEHLAFGRSRADGSHAIPHFAARLSSVSKPAPNNDYHLAKSNIVHPSPTSGYDPASISSGQKTGMQTFNTPDSGRKELSAEERKQKLDKIMDIMGPLEVFDMFFQKTDLAMAALSKLLPPRHRGELLVKVYLEKVDWLHRCVHVPTFLRQCNDLHNLPPEKVTQEIALPFLGLYFTVCTLGLQFMSKAEISLHFTEEEAHTLPDTWFHAARSALWASDFFTNHTMESLQTILLLGVFMNNRDRADAAWALLGAAIKMAQGLGLSRLGAEQQIIDGKPLPMWTGRWESVIQREVGRRIWWNLVFLDWSLAPSYNYSCSIQPDQIKTALPANIEDEDIIDGMPLRPQPLSVRTGMSFQLARLRFAEISQRQIWQANNNNHPPYSFVLSVDGELRKAMMELPTFFQPDPTNKSPPPKEPKALVQYYEKIILNLAIHSRMLRLHRPWLSRGYEDDRFAYSKEQCIRAARASLRMMSDSEGTAAFLEKWWLPLFYVSVSGLVVIIDLLRTSRKDMFTSEFQAKVDEVKGALGQMREIADVSHPSRAAVKVMALLLAEIEERRKPPGSALGKRRSSPDGDDEESGLQRAVKKLILQAQLEAESPSASMGGLTPQEINIGQVSPATRAMNEQREREGERPVFDAYPMPFVPVPPTINNATDPAPQQQPHPNQYIGVSNASPFTFPVDTTNATTFPAFDTATTRGYPNNQLDPTVQSMLANYFPPQANTSNSIGSATAPQAPDDFLSRVFGFGWDGVGTTGPPATLGEAGLDVLGGPPRMSGQGQGQGQNGQAGQQGQQRRQPGELHPPTPLNAQPPQQSQQLQGANNPYAFGNWANQGWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTB7</accession>
    <name>A0A1E3JTB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033398.1">
        <property type="nucleotide sequence ID" value="XM_019174346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTB7"/>
    <dbReference type="GeneID" id="30191405"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="683"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO03347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="904" mass="101609" checksum="01FD7059CE13A57A" modified="2017-01-18" version="1">MGKHDKKTGKGRLDKYYRLAKEQGYRARSAFKLVHLNRKYDLLSKAKCCIDLCAAPGGWLQVAERYMPKGSLILGVDLNAIKPLPHVTTFVSDITTPHCRQTLRQHMHDWKADLVLHDGAPNVGSAWVQDAFTQNELVLQSLKLATEFLAKGGTFVTKVFRSQDYNSLMWVFGQLFKTVEATKPPSSRNVSAEIFVVCRDFISPKHIDPKFLDPKHVFKDYTSLPTSIIEPAAASSGPSVAATSSSTVSAAAAAARLAANNHAHSNVYAPEKKRRHREGYAEGDYTLHHTASAADFVKGQDPVLLLGGMNKVEFLTDEEKGWLKSRHTTPDILANCSDLKVLGKGDFKALMKWRLALRLEIGLDVKADKTADATEEVVVEPMDEEEQISEELQRLRDAKSAKTKREKKRANEKKAKDLLKLQLNMTAPEDLDTHDLALQGEEEIFDLEENENEARRQGKKAGLASLAENAGMDMQSESESEQEEEEEEELLDSDEERERKTAALEGQLDGLYETYVEQKQERDAKWKVKQDRAKDKNYDAWHGIQEKSDEEGSEAEHEEDEEGGWDIVRNKRAKYGEGDSSDSDSDEEAVPAKKARKSVQFEQPSRPAGSGGLMTNLQEAELRSQRSRQAQVWFDQPMFKDVGDLAALDAEEDDESEEYGEEEDEDESDDEDVEMEDDASTLEGDDFEIVPQEAEDLEPEWDVDDEDQDEVKKKIIQDKGLLTAEAVTLATQLVNRQTTADKLMDQGFNRLSTQHKDGLPVWFLDDEGKHYKPNIPITKEAADALKARQRALDARPIKKVAEAKGRKKMKTAARLDKARKKADGVMESEEIGDGEKARQVRRMLAKAAKGKEKAKDRKLVVAKGLNKGVKGRPKGVKGKYKIVDARMRKEMRADKRIKKANKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW37</accession>
    <name>A0A1E3JW37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033724.1">
        <property type="nucleotide sequence ID" value="XM_019173917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW37"/>
    <dbReference type="GeneID" id="30190969"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="6782" checksum="99F18B9BCA14537F" modified="2017-01-18" version="1">MSRPRSDLVDQLKSLGITERTALFALSKSNNDMGKARKYGELHETTSGPSFGETSAVLQHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWB5</accession>
    <name>A0A1E3JWB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033790.1">
        <property type="nucleotide sequence ID" value="XM_019173983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWB5"/>
    <dbReference type="GeneID" id="30191036"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="441" mass="48088" checksum="151ED49BCBC75440" modified="2017-01-18" version="1">MSTKPTVLIVGAGEFGASTAVSLLKTGNYGNVTVVDRAPVLPAMDAASCDINKVVRFDYYDRDYCDLAKAAIDEWNKDEWKGIYHQPGVCIRWNDDGSYDANYSKKVFENVKEKIPSVSLISTRDQFVPHLAPNNATIPVTDPASNALGYFNPYGGWANAAGAVEKLYKDLLALGGTLEAGVDFEELLFTEGGKDVRGIRTKAGKEYTADKVIVALGSWTAAHPALSGLLPKGLLTATGQVVAAVQLSPEDAKRYADIPVSMHYDGSAFYMFPPNKDGLLKFAFHAAGFTSESGVPRTATDPEAVQWTEENKKGWIPKASLAGLRHQLDVVYPELAKMPIAYSRMCWYSDVVDGDWVIDYSKQYPSLMFATGGAGHAFKFLPIIGNLIRSRFENTLEPHLVQKWRASRESAAEDPARAGMQRKPLDLNEFVGEAELGGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX95</accession>
    <name>A0A1E3JX95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034096.1">
        <property type="nucleotide sequence ID" value="XM_019174289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX95"/>
    <dbReference type="GeneID" id="30191347"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="230" mass="25841" checksum="4F3F4ED0D219FCF7" modified="2017-01-18" version="1">MPRSPSPTLSDSELLDSIADSFDYSAHREARMEALAQQVKAVKNLRETGDGEYGRVVEYKEEKGMIERMAKEKYCLINFFHPDFKRCEIMDRKLAELAPSYPHTLFLKASVDNVPFLVSKMAIKVLPCVMCYVDGRAVDRLIGFEELGQTDNFSTKALEFRLQQSGVFPRNTSLSANLNPLLVGKGRQANGKGSDSEDSEDEDERRRTQQGRGGIRTGMASKGDSDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXH1</accession>
    <name>A0A1E3JXH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034111.1">
        <property type="nucleotide sequence ID" value="XM_019174304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXH1"/>
    <dbReference type="GeneID" id="30191362"/>
    <dbReference type="OrthoDB" id="2570906at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="17624" checksum="B7DA53C76EFBC70B" modified="2017-01-18" version="1">MEAMPKDVSYDKDMLGALAILNEMLIDELDRTLSVLYQWERQRFIPAYWLPLPPLPDLTFEPPLPAEQLPIYSTDDEGNDEPAMTPYFIHICRHLLRLQRQGIDRKWFDLWKELKPDEQLWIYKLEPPDHPVQPWDIALRPVPVTSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYP0</accession>
    <name>A0A1E3JYP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase NRDP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033982.1">
        <property type="nucleotide sequence ID" value="XM_019174175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYP0"/>
    <dbReference type="GeneID" id="30191233"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="69755" checksum="C8E75CA18A739656" modified="2017-01-18" version="1">MSHEVVYDYVELVDPNLVCAICQSALVDPVTTGSCKHTFCRDCITRAISHNPQCPIDRSALSLSGLRDTEQLVKLMLDELKVRCGADGCGMVLQRGLFLAHLRSCPQAIVTCRDDDCGLSMTRHRMPHHRAYDCFQRRMECKKCGTILVFKDQTAHANEECCDQSSDSCDLCGETLGADSHMHKWRCTKVRAPCPHAHRGCSSIIPRADIEAHLTTCPFEAFSGFFDVNETRFKSLELKVESLQSELESVRSHLRRVEGNVEVVSRVRNTSGGGLSWPAHQVDPIVPVPGRRSTTAPDSGSPRPEALPLPPSPSPVTPTLTNPTPGPTTPTPARNPQPLSFGSSLPTTRPDMTHQRSLVAPSFGSHHWDDVLNALKGVVVQLAAGLDSMERRNEVRTMTESLRVLEEVGSLRAIVTTMRMQVMMDRPSRPGRPSRPGSLQYQTDSPYRASQNLPRTTSRPSLSLSTRDHDSVSIPRSSSPISPTRTTHSVSVITDRDDDAEETASITESVVFSAQGHPPPSPSAQSSTSSLITATNPRIPKRGSLSRAHRTSSLGQGPSGEAVGMSRNSGSTVGRSGAGLTGRPVAFPPAADDTVAGPSGSGAGAATIGRSQGRLSMRSAGNTVGSIGRFMRRNTERERDRSGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZC0</accession>
    <name>A0A1E3JZC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034300.1">
        <property type="nucleotide sequence ID" value="XM_019173595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZC0"/>
    <dbReference type="GeneID" id="30190645"/>
    <dbReference type="OrthoDB" id="2574879at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="283" mass="30866" checksum="CEE305809299CD68" modified="2017-01-18" version="1">MSGGFVAPSGSLDQAKRDGDSATESGGVQILTRLTPKQEARLRTHLDDRLASLERDERTFKLKSLPSLLSRLSPLLQLILQIPPFHPFDHLRTSYLLTLTAVIPSYISALPLIGGSDILSDHKGDEETQEGEQEELEQMQAGRVLRAVLAFLKEVDRGWLAVLNGEAWSPPPSAFARLDEADSGEQDWEKNVLLGGTPVKVSYAGQVDQTERTRLRSIILTGRSKMLAWARGYGSFPGSSLPGSAATPNSLKGSDAGEEEDEEWEADILNMWNGTLEAVAQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZC5</accession>
    <name>A0A1E3JZC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Omega-6 fatty acid desaturase (Delta-12 desaturase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033907.1">
        <property type="nucleotide sequence ID" value="XM_019174100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZC5"/>
    <dbReference type="GeneID" id="30191156"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="49595" checksum="4E5DF8E74DE5548D" modified="2017-01-18" version="1">MSALRQRPVSPPAGQAEKDQLRDAQGHTFAVPDFTIKQLLDAIPAHCFKRSAFRSSLYILQDVAVITALVYGAFHIDSFLSRFALSNVAFYAAKAALWSAYWFVTGLFGTGIWVIAHEAGHQAFSSSKDVNNGVGWVLHSALLVPYHSWRISHARHHAATGHLTRDEVFVPKTRKERGAPAIVEEGEILGINVSPERQSQLMEALEDSPIVVLYNLFLQQLFGWPMYLARNASGQRHYPKGTNHFNPRSFIFKANHFAQIIWSDIGVSIVLAALGYWSYQRGIKEMISIYFIPYLWVNNWLVFITFLQHTDPVLPHYTANKWTFPRGALCTIDRSFLGPVGPHVFHGITETHVAHHISSKIPHYNAWEATEALKNFLGPAYHKSDENMFVACYKSYRDCLFVEDDQDVVFYKNAAGIAQRVPIEESGNLSDSGVDMTESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF3</accession>
    <name>A0A1E3JZF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034330.1">
        <property type="nucleotide sequence ID" value="XM_019173625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF3"/>
    <dbReference type="GeneID" id="30190675"/>
    <dbReference type="OrthoDB" id="2568992at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="62739" checksum="18E5B02D427BE539" modified="2017-01-18" version="1">MSEDYLDVPGTVRMYEGPAGEEVVGAEGIKLVPAPSRDPNDPLNWSRGRKYLMLTCVCIYTVSATILSSDLYSVFDPLSASTGLSLDQLNEGTGYLYLFIGLSTLISQPCSLAFGKKPVYLVSAFGAAAVNIWTAFAKGNGQWIASRLLLGFFISPSFTLIEVSIADVFFLHERSFPLGIYLCLLFMGVSLGPLFSGYIYEGIGWKAIIWLSTGLMVIVGLLLFLLLEETSFQRDHSTHIHADSSAATSDGIKPAFSSDRLSGTYTSKEATAKNADVTEETDKKGISTSTTFQVDPTLTTATHIEPSTWPGPKFWKFVKPHRHAPGILLRGLTQPFLLMRLPLIWWSGLMYATYQICFNLIAAISSGILADEPYNFSTSQVGLSFLSPLISAIPGAVFGGLLADKFVLRQARSNSGIAEAEHKLKLYIIPTVLTPIGLLMMGLGPYYGAHWIVYILGCFIVNLVGPLATILTVAYAFDCFHPIRPRDEHGVQACAQDAAPYLLSIIILAMCFTFGFNYAITPWCFGWGLRNFAISSSIIITVINASVFLVVKWGKRLRRSQESYYRWVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF6</accession>
    <name>A0A1E3JZF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034263.1">
        <property type="nucleotide sequence ID" value="XM_019173558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF6"/>
    <dbReference type="GeneID" id="30190608"/>
    <dbReference type="OrthoDB" id="2572232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="29351" checksum="3FDC5ECD80EAF551" modified="2017-01-18" version="1">MSSTTSSPTSTAPSVSASTTVATNDGSSPSTFYKNLFYILIGLLVIFAVFSFMSLLKARRRRRAIIDEAERLGVMVPGIPGYVPMRDRRGYQWLQSNGKQSPEWWDISGNPDKLDEGTGSKARSRMGSAHPSMASLQVPGEGARLRHRASGGRLNDPSDFTPVALVPPPPPPQALGPVPQSSVPHFPNHLAYRPSSMLPPKARFDNITPGELGKLEGLVGEGVEVVGIVRMPVPPWVCQRRGSDDEEDGQEILREWGGVELGIARMQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K091</accession>
    <name>A0A1E3K091_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MSH4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034576.1">
        <property type="nucleotide sequence ID" value="XM_019173871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K091"/>
    <dbReference type="GeneID" id="30190921"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="789" mass="86490" checksum="5885C4379A59DE7A" modified="2017-01-18" version="1">MARSTVPAIPQHRTASTATTSRQNALPPSPTNTAYSRRGGRSNSVVTSVRRHGISRPPTRASTHADDSPPFVVALLQGKGSGNEIGVAAICLLTGKTVVTQIADNATFHKTIQHLYSHPPSAIIVPDTMLQDDNKQQYLKHERRTIGDGLLVEQLEEEFEIECMGVERALWNRETGRDFVESLAVDDELKASTLMAVEDKFYALCAVSALFKYLKLEKGIEIQERSLRIRYAASEGTMFIDVDTARSLELVRNGLTNKTTNTLFSVLNHCHTPMGSRLLRTSILQPGNFVKLIDDRLDATQELVKCGDKLTIIRSKFASVAQLDLDSILSQISQQQLHIMEVNVTDTRISLLLNLMEYLQVVQALREELANTESHILRSIAKDFSGQQLDQVFGIIDACLSREVSVGKSAKGQNSRISRLFAVRASFAPLLDVARQTYQENLQDIYDSTHSFTCQVENKGRNFYFTVPADDIEHALPSEFYGELQLKRCAKLSQSEQEVLLISGQIVANLISEVMGTLSGLYHCTEAAMKLLTLSQVRPEFKDTLAIHSGRHPILDGTLGTGECVPNHVYASRGSANFQIIQGPNMSGKSTYLRQIGILTVQAMVGCFVPAEYACFPLPDALLSRLSNDDSMEKCLSTFAAEMATSAMILVGLATPRTLVLIDELGRGTSSLEGMGISHAIAEALITRKTLVFFATHYHDLAVILGNLPGVVKSHDASKETSEFTSTFSYKVAEGAAPLSHYGLETAKLASLPQSVIERATEVAEKLSALEEQGRGPSRSILGDILTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1G2</accession>
    <name>A0A1E3K1G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034132.1">
        <property type="nucleotide sequence ID" value="XM_019173427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1G2"/>
    <dbReference type="GeneID" id="30190474"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13950" checksum="1EA24BE480CC78A4" modified="2017-01-18" version="1">MVKDYSVNVQGGEGVQGYWHDPHLGDQFFSNSPEGSVESDDVTGLRSDRYAYGEPYERTYEAYDLEDEYGPARLLPMGNLRSPHYSDVDSPLLGSMRDDNEGNVRSKSFVFGWSDEEEVEQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1V3</accession>
    <name>A0A1E3K1V3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034517.1">
        <property type="nucleotide sequence ID" value="XM_019173812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1V3"/>
    <dbReference type="GeneID" id="30190862"/>
    <dbReference type="OrthoDB" id="10411642at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1100" mass="119277" checksum="D7C05280FEC3F7E0" modified="2017-01-18" version="1">MVPQENPRKFAWINTSRKRPSSAKQRKLTQPPLYASQSVSKPVRSARKPAVTNENELTPQVAKKRPLPLGLPTPAATDKPDKGKGRAQDRGAESRDSPMPLRGGGRLMVGSTGSGGMERFKVHGDGESSKSKTPTSTRRSPMKEPNDSRQRPIPRTPNLYQSLSPARRSPDLGSFPVESELETPEPICGTDTMRRVREINGIPPRQKAPQASPTKKRKRGASSGENAKSPRMATRTRSGKGERPTHRTARGLPLAEHPSSDNDPSRSPRPAKKSKQAEPPHHFGNIFARPREGKSAQKSSPSSHASRKSTPVRSSSTAEDSVSPIPKREPLTPKKTPRRPRPPSPAPISSPSPRHIQANVRTGPNELTPGASQQSFELPARQTSGGPSRLLSSLHPTGEQDKQMVYHHESFDLVPPKGMAGGVQEGQPQQAEGRVYVPVDTSETLFMAGNDVSGNVLSPSVREEEHGRGEEPASARQSSRIAALARSSPSGTESFLPKVSKKPIQTPVREWVKMESQESQQSQQSNLFGDEREEAARNLAESDEGCEAEAGTLDPALNETYADNNLFQSHPEGRVPTSSQSSTGNVASRTQSCEKPSQSREEMPIVATTTKTRSPQQQTPQRTSQRIGGAAMGQMATSPLPASASRRPPRRSQRSRDNEEDDLMDEESDLRSSQLGPTQSQGLFQTIPREASLAASPSSTQTTPTQPMRQSQFTESPVSQHGPFSPAELASARLPDDLTGPGGSDLVAQWPDTERDSSPIANSVARGPAVVSGEKPRMRKRKQRGEAISPQTSGDVLIGESDDEGRKVVSSSAKMPRQAAADTESSEKKEEDAVANAEGESEKPQKRDAFSVLMGPRRSISAPRSTGKGKDVKGKGKTPAKSTPKASTVRKPATRSATKRKTPRAQPHDEGQTSLPSQGFFKNRKLRKTEDQIRSFDKAFSEEEDHDFEEEQEEGNASAGPSRTTAHLSGKPLISLLGRVPHDPRLNEGGKREIRRRRLVERAQATLKRTPSPLTPLSPSPSTGSPLPPPPGHRDEAEEDEDVHPFGEEMRQQASREDGTRYRQSQATTSGSQTSAGVKTPGSTKNFIDMLGGSSSQIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1X7</accession>
    <name>A0A1E3K1X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034641.1">
        <property type="nucleotide sequence ID" value="XM_019172915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1X7"/>
    <dbReference type="GeneID" id="30189956"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51877" checksum="D241719B5C74CC4C" modified="2017-01-18" version="1">MATITPPIHPEQEEPGHQLTDDSAPIKKYPFYRSVGFQVLICSLISFTAPGMWDALGGLGAGGAADVTAVSIANALVYGLFAVVCVAAGAINNRIGLKWGLALGAVGYPLYGAGLYVNNTTTHTAFMLWASAMCGISAGFFWAAEAAVIIGYPSPKDRGFYLAIWQTAKAAGPIVGGAINLALNAGRSTAGSVSSATYIVFIAIMCLGLPIATCLSDAQKVHRRDGTRIVVSKQETWGKEFKAVLDLALSRRILLLLPAFFISYFYNGFLSTFLTEYFTVRSRAFSSFFTNFAGIFSSFIIGTLLDRQSIPIKIRAKVAFGSIVTILIGTWIWAIILQNQFYNADTAPVWDWFTAGFNKSYALVFFWTFAGQAFQQFLYWLVGQYTTDLSSLSHHTGILRGVEAAGQTVAWAMQSEGNANHFVSIGINFGILLICIVPTWIVLSELEGSHEVVVVEGTDTQSVKDGSVESAKSSEKDLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K282</accession>
    <name>A0A1E3K282_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034761.1">
        <property type="nucleotide sequence ID" value="XM_019173035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K282"/>
    <dbReference type="GeneID" id="30190076"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="492"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="658" mass="72898" checksum="677C491FA29BCAB9" modified="2017-01-18" version="1">MPQPSNVPFPTPPSYRTDSSQASSTASYVTAHSSPYNPPNPAYTPPHREYPPNYYAATQPSSPQQRLESQVRRSRGNEYLLGLNTAMSNLELHGNGTEDAPPRLTNTNHPLSYQEGESGRQSYYAESPRQRYHSTPAMSPISPNTNKTLPPLPSGAQSRPLESFSPSGSRASPSRPQHMAGASSTGGTVTYGLPPPPPLPPRPTSLPQYMLPYANPDRSSPQRYCPSQHVAAPDPRSGLSPGRPQSDPQITAARPERRISPRGKENFQPAQPGPSTPNRKAPQNPVRSNHRRAKSDPDGEYTPVIDLTVSSPESPSSPSASARRGPKGSSPSRYRAHSDIRSSFLTSPSPAASPARRKSPSKPTANTSGLASSPKKPLTPSKVGAQCSGFTRTGAPCKRIVRAHAPYIATPRRENDDDGDVRSERVMGRYCKDHAGMICKEKGFYWRNGEGEHASKVWVDFEDYVLPDLSEQTQTLIRMVMESKLTPKEAPGYLYVYELRGEHHRYVETDNLSFYKCGRTDNVPRRIGQWTHQCQSKTPSLLDIFPRPNTSSTRPKSSAPDRSQHLITSFLQGATTHVIPPLPAMKRWERLVHIELAERCALEEASKEAFDRVRLKCADCNSGHKEIFPLLKQDSKSNYYIVEECVERWGRFIEAIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C2</accession>
    <name>A0A1E3K2C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034672.1">
        <property type="nucleotide sequence ID" value="XM_019172946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2C2"/>
    <dbReference type="GeneID" id="30189987"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="79" mass="8494" checksum="A1767CBC8328AAEE" modified="2017-01-18" version="1">MDANENQHVTENPQAAPSSNDNAQQVGTQQDALDKGVSAAFKQFGYNNVDNSTVEKASDAIRSGFKSFTGKDFPIADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2E8</accession>
    <name>A0A1E3K2E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BNA4</name>
        <name evidence="13" type="ORF">L198_00899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034797.1">
        <property type="nucleotide sequence ID" value="XM_019173071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2E8"/>
    <dbReference type="GeneID" id="30190112"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="175"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="536" mass="59211" checksum="C07E35EFBEE1E615" modified="2017-01-18" version="1">MTQERSRKALIIGAGPVGALTALSLHRQGWDVELWESRDGKYYHGRTMALTDNLLDPRGEDAPSNLRSINLAISSRGLSALQSVDPALATDFLEEAIPMKGRMIHHTDGKEESQLYDPIHGQCINSISRPILNQRLVQALPEGIKTRFNTKLEHLDFKAKRAYASTSKEGVVPGEEAGEEQKVTGKARGEGTAFDLVIGCDGSWSKVRAAMMRIDRVDFSQSFIPHAYIELHMPADSSRPEGFAMDKNHLHIWPRHAFMLIGLPNKDGSFTLTLFLPFDSLDKIKTREQASAFFKDNFPSAVDIVGEKLLLDDFENNPRGNLVTINCTPSAWSSHALLLGDASHSMVPFYGQGLNCGLEDVRVLSTILARHKISGKTSIPLGKKDDGLELALRAYSVEREGDLKAICELALQNYTEMRSHVLSPMHHLRRHLDTLLTTLFPTLSRSSLPTTSLSSLLASESSSTAFPTNKVKGWTSMYNMVTFRPDVGYAEAMRKESWQKEVVGWVGYVGGAVSVGALGLGVVVGARLARTWLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2L5</accession>
    <name>A0A1E3K2L5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034857.1">
        <property type="nucleotide sequence ID" value="XM_019173131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2L5"/>
    <dbReference type="GeneID" id="30190172"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="18422" checksum="71AFB6AB74B10E7A" modified="2017-01-18" version="1">MSSAAVDSAIKKSANDLAKELEVERVLKAFKLNPYDILDLPLSATESDAFDFLKKAHDHLIDLDKRKDIDMIMTHARTQVLKTILGSGFSTNVADDDPRLANLSPPFEQQVRAQGREILVEDELARRRKTKLAYANEGAEKAKAEAEIASRKRKLEDQSKWEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K337</accession>
    <name>A0A1E3K337_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase-promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034913.1">
        <property type="nucleotide sequence ID" value="XM_019173187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K337"/>
    <dbReference type="GeneID" id="30190228"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="14"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="70917" checksum="0DFE1E94CD3AD9D3" modified="2017-01-18" version="1">MPSNIPPDAKVRMANDLRAAVRELRDRGLMVAAKWASELLASLPKEYRSTPNLVFSPPPQMSSLPPRSPPGHARPSIGDFLPSPGPGAFSGGVKGPGTRGRTMHGIEIEEELDILDEDEFQLARGYFDLKEYDRVVWVLRDARGNRARFLRYYSMYLSADRKAQESLSHFLDTKEERTALYPAISALLSELKDETDPYLTYLRGLCYMRLDRKPPAMKSLMESVRAKPYNWSAWSQMAQLVSSADMFISLKEELPSTPMLTFFAICCMLDLHTATDLVMSMIKELLEVFPASVHLKAQRALVYYHMRDFETAEREFDNVQKLDPYRMEEVDIYSNMLYVMNKQAKLGKIAHEYAEIDRNRAEVCCLIGNYYSSRSDHTKAITYFKRSLMLNREYLPAWTLMGHEFVELKNSHAAIEAYRKAIDVNAKDYRAWYGLGQAYELLDMPMYAIEYYNQATSLRPYDCRMWTALATLYESLHRLPDAILAHTRALLGADKVQTMTILLKLAGLSEGMGEWEKSVGYHKKIIALGEKEGMGGPAEMAGSYVGVAEWEMRIVMELLEKERDNANGEELERLKLEVRDADLAIAAQYIERVAQTNAPQRDRAENLLRALRGYEMRNVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K390</accession>
    <name>A0A1E3K390_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034978.1">
        <property type="nucleotide sequence ID" value="XM_019173252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K390"/>
    <dbReference type="GeneID" id="30190293"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="650" mass="72929" checksum="190BC0E42B9EC93A" modified="2017-01-18" version="1">MPPYALITPFLIRALLHLPFPQTFFQPDEFYQALEPAHQKVFGYGYLSWEWTDLPRRVVEAAVGLGGQDVVEKWWDETVVGGRMRGWIWPGLFTGVYKILQSAGLDQGVMLTLAPRIVGVIVAGLTDYYTYRLSSKMLGHGSAPTALFLSLTSLFNAHLLPRALSTSPETLLTLMAIYYFPLPHPVPTHIEDLKRGARLIPVGNRGKSAKEAEEAEMEILGVEDSDATFWGVNELDYVVMDRTGPAVERWPVHKDRLALSIGLAALAICVRPTMLSFWTFLGINLLYRSFRSKGLLSAVTVAVVAFLSFISVFAASTGFDYYMTGRLYFPLLTFIHQNLFLDISSFYGRTTPLYHLTQSLPLMLFPIWIWWAKGFAAALLPSSILPASLSKYDRQEGMTILARAITFTITTLSLSPHSEWRFLHPLLPPLLLFAIPSFSLSYTPTILGAYFPVRSFRQYLRMDKIPFYTVLFAGVVPFVYLNVWHGAAQVGVMDVLRSGKLGEMQGLVVLGPCHSVPWMSHLHEDVPGWFLTCEPPVGVDASTYQTEQELFYADPVGYLYSTFPAPPSSNALTNLTSYPSHVILFGELLSRSGFLLTDETDDTGLQMKQSTVEQAFEMLGYGQVWEGWDGFDLAQDEDERKGGVRVWRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3B8</accession>
    <name>A0A1E3K3B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035006.1">
        <property type="nucleotide sequence ID" value="XM_019173280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3B8"/>
    <dbReference type="GeneID" id="30190321"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="22699" checksum="77644A97798E4980" modified="2017-01-18" version="1">MSSFARFQRTFQRFRPPPLIPTAVRTIQILATLHLVSSTLAELRICSGFSMLPTLSQHGDCVLVSPLSYWSLLSESHKKTRPQRGDVVVATSPMNPSQAVCKRVLGVEGDLIEIEPRRGGQRKWIDAGGHGFLVDIPDEEAAMDNVLVPQRHGEGQWVKVPKGHVWLVGDNLSNSTDSRKYGPVPIAMVKGKVLARVSSAWAVDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3C7</accession>
    <name>A0A1E3K3C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035016.1">
        <property type="nucleotide sequence ID" value="XM_019173290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3C7"/>
    <dbReference type="GeneID" id="30190331"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="179" mass="19417" checksum="3598ED98B4D36FA1" modified="2017-01-18" version="1">MLMLSEKGDNSAVDMLVGDIYGQDANIFGLKSSTIASTFGKVFKKGSNADRKKRFKPEDIAKSLLYAISNNIGHVAYMNAAKYGLDKVFFGGCFIRGHAATISTLSYAIRFWSKGTMTACFLRHEGFLGAIGAWIKNVGETDERGSPVSRVRERSNSTDGLDEKTNGTALGAKGEEQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4H1</accession>
    <name>A0A1E3K4H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034884.1">
        <property type="nucleotide sequence ID" value="XM_019173158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4H1"/>
    <dbReference type="GeneID" id="30190199"/>
    <dbReference type="OrthoDB" id="2505754at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="58299" checksum="5CFC7DF66BEA5C12" modified="2017-01-18" version="1">MAGSTTTTDPASLPLHPSADPQAAESTVPEPLLVEGETVPDDPEETLSSEDSFPPAAQALIASLRSQLGASEQHVSTQATKLSSLADLAVEHSQLKDQHAFVSAAKEAVEAQLKEEVKKREFAEESVEMLRGQVEQARRGVMALQKQDADRKRMSLMSGMNGLGLGVPQQGEEEVLASTSEQAAKDVKASRRTSMMARSHRRISSQSEPSEVSASLDRQSLVSPNMAGQARLGGLRELRLSSTPPTATHPSPSPPAQPNTTQASYFDESVTQAALQSAVTAKAAALEDANQLRSQLRQLQSNLAESEESRIATEVCLKALREFMASHEGGEGGESAAEALKGISLPPLPTDRDTDEPLQQEAKGSGWGFKLWATGAKSPLQPPSEAISPGRSRAASIATSNTHISPLPTPNEEGTPLGLSGFVSSWTKGVSAASPQNATSLNAAPVPAPANAKLSVGGGGMGSFFRRRTAESVNDKELPAPPIAEDAVDISSPVLRTEEDKEADRRRSNATTLSDLEAELGTPHGSLGAKPDGELEGAKVKFGELERLDEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K507</accession>
    <name>A0A1E3K507_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transporter SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035141.1">
        <property type="nucleotide sequence ID" value="XM_019172199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K507"/>
    <dbReference type="GeneID" id="30189222"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="51864" checksum="C11E2E2E75FD15AB" modified="2017-01-18" version="1">MGFRFLELVRPFMSILPEVTAPEKKVIFNHKIAWTAITLLIFLVCSQVPLYGIMSSDSSDPLYWLRAILASNRGTLMELGITPIVTSGMIMQLLAGAQLIDVDFSLKDDRALFGAAQKLFAMIISLGQATVYVLTGMYGSPSSLGAGVCLLLILQLVSASLIVILLDELLTKGYGLGSGISLFIATNICESIVWKAFSPNTVNTGRGPEFEGAIIALFHLLFTWNDKTRALKEAFYRERLPNIMNLLATVAVFAAVIYLQGFRIEIPIKSSKMRGQRGTYPVKLFYTSNMPIMLQSALTSNIFLVSQMLASRFPENLLVRLLGVWEPLEDSPSQLNAVSGIAYYMSAPHSLTAALQDPFHTAIYIAFICTACAVFSKTWIEVSGSGPRDVAKQLKDQNMTLAGHRDASIYKELKRIIPTAAAFGGATLGLLSVVADMMGALGSGTGILMATTIIYGYFEMGVKENAGIDAGGLGDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Z9</accession>
    <name>A0A1E3K5Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035454.1">
        <property type="nucleotide sequence ID" value="XM_019172512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Z9"/>
    <dbReference type="GeneID" id="30189543"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="40798" checksum="B687DE9D068D4AFA" modified="2017-01-18" version="1">MVKKRGMIFVTFFDSRAAERARDGMHGMKVNRRPIDVHYSLPRPEEIATACSADKNQGSILIVAHPPRPLNLSDVRRMAERYGDIKDVERGHKPLEVVVEYFDSRGAILLQQHMNRQVFMGVELELRHIWDKVGNNVPPPPVSERIPRTSHVHDRPAREPLRRDSYPSARSREYSRERSPGIRDRRASFPSGFHTSSGPGDRSLPTPVAEDALEKARKVQALIQNLSNVPSVVSTAVNPTSRYQPALAPPTHPPYRAMGAAAGYPPSPSFYTTAATQSFPPYPSPSSASTTTNLSYQNQVFKAPPAASPYGQSPSSYPSPPTSFAAPSSNAPPPSSYVPSSNSHVAPPVLNNTSPDGPTGVQDVSSLLAMLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K664</accession>
    <name>A0A1E3K664_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">V-type ATPase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035417.1">
        <property type="nucleotide sequence ID" value="XM_019172475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K664"/>
    <dbReference type="GeneID" id="30189505"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="20559" checksum="C52BED6CCEEE3424" modified="2017-01-18" version="1">MPIPYPLLYLATSSAILIALYLLFTGQGESFNVGRFLAESSPYAWALVGIGLCIGLSVSGAAWGIFVTGASILGGGVRAPRIRTKNLISIIFCEVVAIYGVIMAIVFSAKITGDVQDIHTTNNYYTGFALFWGGLAVGVCNLLCGVSVGITGSTAAVADAADPQLFVKILIVEIFGSVLGLFGLIVGLLVSGKAEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6D2</accession>
    <name>A0A1E3K6D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035495.1">
        <property type="nucleotide sequence ID" value="XM_019172553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6D2"/>
    <dbReference type="GeneID" id="30189585"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="329" mass="36236" checksum="26824C26D80DAE11" modified="2017-01-18" version="1">MASLQNLRPWNSLEERGLPSAGVDSLSGQSAECLERLANYDPPPLPDFGIMKQASVLVGLFEKDGELHVLLTTRAKTLRRHPSQTALPGGKVDPEDEDVIFTARREANEEVDLPLNHPSIHHLTILDPVMTILPLNAHMKNHIVVTRKFLTSREATRLTSMIAVVCFLSDPSLLIHLRPSPDEVDAIFTHPLKGCLTGEVEGKNWEGLSEKGGEWWPYEEEFHSTEDRIGVTGGYRMHRFRSERTPIKGLTSDILIHTATVAYGSSPSFARFASDQPSFSSAISDVVLELPRVINSSSSTSPGGTPRVLEWGGTEVGQRTISGETWALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6E1</accession>
    <name>A0A1E3K6E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035290.1">
        <property type="nucleotide sequence ID" value="XM_019172348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6E1"/>
    <dbReference type="GeneID" id="30189378"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130788" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="24894" checksum="EDC4DFD3C025A7AA" modified="2017-01-18" version="1">MFTSPLIALLTPLQAVLSCAVHRSPDLSSISSIQSQSFPDLAKSFSQGCSVSNVTVALGSSSLSLVDGQPSSTIAVGRGIQNYTCTSGAYVSTGALANLFDVTCLYSMTAGKVDTNDLSTLLPEMAFSALQYPDTLNLPVAIHHLFVDTPGSNTTGAISPLFVGSTDQVLVSKTAASNDLTDPSVNVPWLHLTAVEGQGTLAKSVYRLDTVNGQAPSTCDTEGEDLSVQYAALYWFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6M9</accession>
    <name>A0A1E3K6M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035511.1">
        <property type="nucleotide sequence ID" value="XM_019172569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6M9"/>
    <dbReference type="GeneID" id="30189601"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="103" mass="10391" checksum="14735CE52094DEEC" modified="2017-01-18" version="1">MRDHDAVRASSGEEQVFISPYTSTPCDTGISLPAAGLCASDSPHGALSPVTSSLGWPDDAWAASVSVRPQASGLSAPAPLRDGGGMAGEGQKAGGRKLRSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7N6</accession>
    <name>A0A1E3K7N6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kynurenine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035791.1">
        <property type="nucleotide sequence ID" value="XM_019172849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7N6"/>
    <dbReference type="GeneID" id="30189888"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="37"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="46540" checksum="DE20D80CB0655CA1" modified="2017-01-18" version="1">MATSKSAVIPQAKRMFEGGTHKLDVWSIFTPANVPADAINLGQGFMNWAPPSWILSESHQTMDNEVMANHYSHPRGRPRLLKAISKHYSPQFSNIVERGEDLKPEEILVTAGANCGMFAALTAHLEPGDEVICIEPYFDQYFASIHFQGAKPVFVPLHPPTGTGIKDGSEWTLNIDEFRAAFTPKTKAVIINTPHNPVGKVFTKKELEAIAEVVIEKNVLVLADEVYDCMVYDKKEHFRIATLPGMWERTLTVGSGGKSFACTGWRWLIGTPELTAAALAAHSRIVFCTNSPMQEAVAIGLENAAKHNFFADQLAAYTERRDVLCSYFDQLGLPYTKPEGSYFVLVDISQVKVPEGYPIAETCKGRGKDFEFCWWLCQELKVVAIPPSEFYSDEHCKDPELLHAAGKRLLKLKEYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7U6</accession>
    <name>A0A1E3K7U6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035159.1">
        <property type="nucleotide sequence ID" value="XM_019172217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7U6"/>
    <dbReference type="GeneID" id="30189240"/>
    <dbReference type="OrthoDB" id="2578343at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="704" mass="78054" checksum="35A33BD078D6E796" modified="2017-01-18" version="1">MHLLPPLRGHRCRIPPPHIAPLLQTRRSKALQPTPDLKHLQSFRGTWRFSLVSAAFSAYPGQSPTGPRGSYGKAKLLQLVLTVVMERTPELATGVVWENCYHLPPLPSVSNIVIQPVDRHARQDGGEDTTLTRNTIIEWLCPSATRFHVSLPYGPVGVESIRPLPSLPRFRALLLKVVLCKLDPRGGLFIKGQIVSPPWCSQSGPNLLLSCSSSQVNSELSSNLFLGGLSVFLFSFSSRYPAFYIYDHRLASPHAIEYSAQAATLHLVTAATPRRPLDVPEDPRMRIRRSPRRAAAARVANTADIVEHILDHPFASKDLASFLRVSPLFFHIAGRKLYSTLPISNALNPFSSSSHGGERWGGRGPYGKGQFFPYIRTVVVEKAPIPNRPTWAGWEELAPLPSVENVIYKRGPTSKLCCSATRLYLSTPRYASSEDSLQRVPFLPNVHTLVLKGRAADIENHDLVAVEQEHDAVSAWCSNIREVHLLLWGDVEYPYGPLDHIGGPSRSGVTYHQLMMLFGASSVHLSAFFYGRLRYSIRDLASLENVEVLHLYNVEEILKRIANCNPSGWRVGVGTAEEMLTGVKESFIRKEEDASQDEASEDEANEEEASEERVSLEGASEEGASGKEKKSLSVTFHPGAAFYKTFGSYGHSQKEAWYRSLVLEPSAKLVALRQELADMTGEPADYFSGLSEKNVETILDTYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K832</accession>
    <name>A0A1E3K832_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microfibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035532.1">
        <property type="nucleotide sequence ID" value="XM_019172590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K832"/>
    <dbReference type="GeneID" id="30189623"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="546" mass="61694" checksum="BE372697AB958996" modified="2017-01-18" version="1">MPPKPPKTRYFKGKAPNAAVSESESDDDDEEEVDFRQQNRNKNTQLDPNTVAGGAGKVISDVREISVKKGKGMEMNLGGAKIGRGVGDGGVKLEESSGEEEEESDEEDQNGPPKSTTQAKEEESSEYETDSEEEESEEEPPKPVFRPVFVPKGSRNTTAEKAAAEAEEARKREEEMEEERKQASKELAGETIRRELAEKEAAKIVHDIDDTDGLDPQAEFEGWQARELARLLREEKVQAERDAEKEEIERRRAMPEAERLKEDMEHAQKTREKEKGDMGFLQKYYHKGAFHQDDELLKRDYAGATESSVDMTMLPKVMQVRDFGKASRTKYTHLADQDTSQGGWGAATRGGGGGAGAGCFNCGGPHLRRDCPNNDINGPNMIGGVSVPGAFAPAGGSGANTAALAVGSRTWGGSENGRVSGEERRTGDQSARGSTTRDSRDRRHGAERIDSRSDRDDYKRSRDRSGDRAHRHRERSRDREDHGRDRDRERRRDSERGYHGRERDSRRDSPGRKRDRDDRERDYDRHDKRRREESDRNRDRDRRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K890</accession>
    <name>A0A1E3K890_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035592.1">
        <property type="nucleotide sequence ID" value="XM_019172650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K890"/>
    <dbReference type="GeneID" id="30189683"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="421" mass="46463" checksum="75EC4E6A9A50C4B8" modified="2017-01-18" version="1">MNPDQSAPLQFRGSCVLGSDQLQSAPSEAADVEDAGDFGSRTGSYATHIPYPKIQIQSLSTFAAARTPNAPTNTWRLLHSTVLPWCPRNDALGGRGRIGPIGLVAANRSGSPDVYSLTDDLKSKILGDALEARYMARLPPSRRPDLYRHTSKFTPDLIAQDARPQAIGLATVPFREEDGIGNYGKYATPKSSAPPQVKGQVYTGRTARFSPGATSLMPRRREHERPLNVEGASQYHHPWNKAVRANAEHYDVEWATNMFVPVDADLSPSNDLKNALILLSVVGEAVLFVLLDSGCGDQYANKTMSAALPFWDDGPAYIGTDRRNPICEGFVLWDWTKPDRPYKAFDIEGTLMFPAARHQASCARREPRRSPGVYLSFHLRRGRRLGCGVFPIVPYDIFLAERHGRQPYGLRSGVLCDEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD29</accession>
    <name>A0A1E3HD29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000061">
        <property type="protein sequence ID" value="ODN74258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027804.1">
        <property type="nucleotide sequence ID" value="XM_019180222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD29"/>
    <dbReference type="GeneID" id="30197464"/>
    <dbReference type="OrthoDB" id="10501005at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="409" mass="44925" checksum="E05E58A257CE26A5" modified="2017-01-18" version="1" fragment="single">MSPPVPQDPIPGTAPPAGGAPPNIENKPNIEKSGETEGGDQQGDKDKNGEKEGGFEGPKTDDSGSTISFDTPLGNTTRPRDRPDTPGPESQPIHPGMLALMAQLANIQQELTDHIKEQRATVPAPAPAPVPECPKVFKRPDTLVCPTLSWYTNDPFAITRHLYALEVYLTAARPTMLPEHYPLWAIEQCNFSISKVGEWFTWGLEFGRKALTFRIWSKQWKEKVLDPDWVRQARTAVKFKRMEGTTPQHFDAFANSIRDYQHLLSTSSDPISDQDVKRFLKEGLSSHMLVLDVDNALEQKQLNINTISVTDLIALMSKRVTVCAAQLAAFQSHQAASRPPPRPAQAPRPAQARPAPAPIKAISAAPAQVAPAFAPPTAAEVQVWLDSTLRLPPGVEGSRAREYLRQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF22</accession>
    <name>A0A1E3HF22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein CMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08189</name>
        <name evidence="3" type="ORF">L198_08202</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000057">
        <property type="protein sequence ID" value="ODN74938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AWGH01000057">
        <property type="protein sequence ID" value="ODN74951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027847.1">
        <property type="nucleotide sequence ID" value="XM_019180160.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027860.1">
        <property type="nucleotide sequence ID" value="XM_019180173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF22"/>
    <dbReference type="GeneID" id="30197400"/>
    <dbReference type="GeneID" id="30197413"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="333" mass="36268" checksum="A7C22B9D94501B55" modified="2017-01-18" version="1">MVQETNKAIKTGGDDLDDGLDYDQDLLADSDAEDVASEAGSEIGDEQEDVRDGGAPQYVIEGEETEISMSPVIEGKKRKLEEDETVDAPAAADDEQAKAADKKRRKKEKEKERKQKKRQNADKVSGASSAPTHLAKEDLSAILLRSIRESYPSGTAMEIEDIIIPQDNILPPPSYPAPIANPSNPFKPLQQKLDTLIENKKAPKSNGTPKVIILALSGLRCADVVRAVRDVKGEGEVVKLFAKHFKVADQVNYLARTKVSIAVGTPSRVGKLLAEGALKITKHTTLLLDISHQDSKTRTILTLPEVRDELWKSVFGGEGRKKLLENGAKVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HNK8</accession>
    <name>A0A1E3HNK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_08031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028003.1">
        <property type="nucleotide sequence ID" value="XM_019180004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HNK8"/>
    <dbReference type="GeneID" id="30197242"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN77296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="41545" checksum="3E06C7AC7F71EA3D" modified="2017-01-18" version="1">MAQQYAEMDPDEIEQDAYEIDTASSSQTSTLTWINWYTSLTGHDYFCEAHEEFIEDDFNLTGLQSMVPFWREALDMVLDVEPEEDSSKIPDVSIVESSAELLYGLVHQRFILTKAGLSAMVEKYDLAHFGACPRVFCNATPVLPCGRSDMPGIDTVKLYCPNCGDMYTPPSSKYQNVDGAFFGTSFAPLFFQTYPELHSAPFVSPPPPPSSSSSSAPTPPTPHPHPQAHAHAHATPHPNANANPNPHGGQKPALGKVYTPKIYGFRVSEQARSGPRMGWLRERPANVDQLSQVDYRGRWKVGGGVAAGEGEGEKDGEEKDGGGGGGGGRGKKEKEKGRLFDEDEDEDDDEEEEEEEEDAGVGGKGGVGGKVVPESSVAGSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1C9</accession>
    <name>A0A1E3I1C9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028283.1">
        <property type="nucleotide sequence ID" value="XM_019179736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1C9"/>
    <dbReference type="GeneID" id="30196959"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="622"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="764"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="853" mass="94595" checksum="AFADDFAAD401759B" modified="2017-01-18" version="1">MSTLDAVTPPKPSSLPHHIVASLLVNLDSQADQLRAKKQGGLDLEGLLYFQRAANYIAAAQIFLHANGLLSEPLEVSHVKNRLLGHWGTCPGLNFVYAHTNLLISNHQEEKNAPEFMFLTGPGHGAPAILSTLFMEGSITRFYPEYPMSREGLEYFIRSFSMPGGFPSHVNAETPGALHEGGELGYGLAVAYGSVMDKPDHITVAVIGDGESETGPTATAWHAHKYIDPAESGAVIPILHANGYKIGERTITGAMDDLELACLFTGYGYQVHIVEYGSKSPEEASDHEHDIAVQYDMAVAMEWAYQEIQKIQSAARSGKPIVKPRWPMIVMRTPKGWTGPRKAEGKLVEGNWRAHQVPLPSAGAKGEEFDLLKSWLESYGPDELFHARGIIDSKAVRIIPRDQERRMGMVNATYRDFKPLKTPSWKDYAHPIDEEISNMKAVGEYVAKVIELNPKEFRIFSPDEISSNKLDAAFKVTQRNFQWDPETANKGGRVIEMLSEHTLQGWLQGYTLTGRHGLFPSYESFLGIVQTMIEQYAKFIKMALETKWRGNVAGLTYIETSTLWRQEHNGYSHQNPGLIGSFISLPRNLARIYLPPDANTSVAVVDHCLRSKNNINLVIGSKNPTKSFLTPDEAERHCIAGASVWERFSSDNGIDPDVVLVGAGVEVTYEVVAAAALLRNEGIKVRVVNVTDLLILGQTGVHPHALTQDMFDSLFTADKPVIFNFHGYPKDVSGLLFSRRAHVGRSRASSYSVLADTNTDSALQFDILGYIEEGSTTTPYSMLRLNDVSRYSLADVAVQRVSRAQPNHPVTVRAHALSSYWKHVLVEHDKYTKDHGDDPAWCKEIPEIREDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5K5</accession>
    <name>A0A1E3I5K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028360.1">
        <property type="nucleotide sequence ID" value="XM_019179672.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196895"/>
    <dbReference type="OrthoDB" id="2575925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="749"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="955"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1109"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1369"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN83788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1384" mass="151002" checksum="0259849A519A0F5B" modified="2017-01-18" version="1">MSFSDDGLDPLPTEFDPDRVPSPPVSPPRPPAPQPQEDAPVIPSDEEMEVPEEEEEGRYAAEEDEGEGGMELMGYLQDLIDDGEEEQPEQAGPPAEREAAPSSSPLSDLPDLPDEIDFPFTRRSPTPPASVSSAAPSEVIPHAESSASAAQRAATPSQYETAPAASKSNDTTQSVNPSAGIKRARAQLDIIATSESVRGINRPKSNGSQSATDTGDEDRHSKKAKSDKKPRHTKKALDPTGTGLKVKGPEKVPTRAKVITEAQRKKILKGQTIEVQMSPCQRPIYAAWGKCTQCISKVSGDMCRFRDFRVFPIDPVTTAITGPGYFTDNPWPQPLTPLPTRFSSEFSPAIISATEHTVAPILLPLITSESRHIHTHPGTLHRGIDTAKHRSVCDFCSSTIFGGWWFCKSCGRDYCLECERYFPDSVEGMKESPWPLADAARPRLLKCIAQPPRATQNGKDAGKDGGKPEKKGKELAWHVRGDLQAVSRFEKDEIKEHWLSLSEYVLAGKDSDKLDLAGKLRVMGLRGDGEATGLVKEWIEKAEKAPEPEKEKGSEEDEEVRDLDDIFKEMNDDPPRQPTPPPKSPSAAKPPKYVYTETCHPASHVLDPLTSSDPTPVAHLDPPDPAGIPNLPYMYLPAPNLTDPLFDELWAKGEPIIVDGIGSRMGEWGPDRFREMFGSEKCSVVDCQSNDPQDSTIDQFFAKFGEEGEKRGNKILKLKDWPPGDEFANTHPTLYHDFSRALPAPDWTRRDGVSNLYSHFPPGPTRPDIGPKMYAAFAADEGPGGFGSTRLHMDVADAINIMLYAAPSKEIKPGCAVWDLYPASAADKIRDFLKSKFDKTHSFIDPIHSQRFYLDSDLRKELFEKKGISGWRVWQYPGQAVFIPAGCAHQVCNLSDSIKIAIDFVSPHNVPRCQRLTRDFRRENYMKAWKEDVLQLYNVLWFAWMSCREARVRRVQEEKDREVREKEREERSRGLRDGLSSQNSRSRERPAPFSACPSSGPLSPGFAMGGMGMGIGLRGWGEDTTTAFRPNFSSVRDEPVRSVNISSLRDEPIWNGNTSSARDEPVRGAPGLAFAGESSLRGAAPVTTSGVNGKEVEVTATLASALGDKANPPASASTPNASKKTTPGDVVSHDAPGKAAKRQLAENLFNLTLNHHDPNPAEVFLASSAYIKSRKAFGLDQMGQANAGLGKGTPVGGPAAARATRSQPNQPLTAPLNDLTRVSSIPSSSTRPPSRSKNKTPKAIRSAYDDFLAQSKNEGLGADEENLAELAGLGVWDRLRDTGDRGSTPILTVNGNSESIPQTIPLDALLQNQAPSGTAETAMSGEAAEAETELGLIAEHDGYGDAPDLDLGEQERIDLMAQIQSLNENGDDDDDIEMDGDGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDT8</accession>
    <name>A0A1E3IDT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028649.1">
        <property type="nucleotide sequence ID" value="XM_019179401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDT8"/>
    <dbReference type="GeneID" id="30196610"/>
    <dbReference type="OrthoDB" id="2577415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="57793" checksum="E23C5C42AD44ADBE" modified="2017-01-18" version="1">MCDDMGTNGMDNSFESFEFLSAPSGDADLSAADNSETLGFVGDGALYAADEGSVLGNGLGHGTFPAALDTHLPGEMMIQVAEEPAQNRVPQVYTQVPIAFPQQQLYPAAPVAPAHGSVATGSSFAPAVPGIQGDHQNHRDPPTNGLHVVASGVSEDPFADITLETINAFNGPCNPIFNTHRLLTTPMAPIGVPQASIIMPTENTQQAAPPMMDWTNYPYEPTADHMLPPAAMPVDPMADISPFHVPPAAAATLGLDDSSIVSAFLGDPPYQSMDPRQMPVTNHIYQTPTGAQANPDIAQQTNHHISAAPQPAPSFVPSPHVLGNDDSSLTLNSSATQPAAKKSASKRKRQSADEGDKGSSLQVTDEDGETTACIIKNGKKIKVQLEDGEVVQEVQRVWTGCNECRRRRRKCNRLHVDKKEPCDSCIERGIPCVYSDKERVHASKGKKKSPEEAAAFRAKKEAQKIEDARLLAEGKSPRRKTKKNVQARMVIRSSPIKSKSASKKGKEREIEADTTSASSSDFSSPPASSFDEGSHFWSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEG0</accession>
    <name>A0A1E3IEG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028807.1">
        <property type="nucleotide sequence ID" value="XM_019179190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEG0"/>
    <dbReference type="GeneID" id="30196388"/>
    <dbReference type="OrthoDB" id="2576622at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="34840" checksum="858BDA1374A5DB64" modified="2017-01-18" version="1">MPLFKLTSKRIQKRQREDELGITELKAKMREAGEDVPDSEDELSGEDSDEEDGSDDEGEEEEEDEDEDEEGGSDAEGSESGLKRKRSGSESSLGSEEEEYDDEEDRLDLTPEEALQTPIYAFAPPPSSSDDEDVEGKDKEESDEEVDDSKMQKLCALCPGKVMKNEHMVEMHLASNAHKRSAKRYEAHLDAHNPSPDTDPRTIALSLLPSHSAPAPKAEKTEKKKKKSVSKKDRLTARLAKAQQSVSTTLEQQPEKLDAEKLKEVVEGKGLNRKAKRALVARLKEEGRLVVGLGEVGEKGEKKEKPTAKKAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFQ8</accession>
    <name>A0A1E3IFQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_07265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028754.1">
        <property type="nucleotide sequence ID" value="XM_019179273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFQ8"/>
    <dbReference type="GeneID" id="30196476"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN86571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="56911" checksum="064711E21054F05C" modified="2017-01-18" version="1">MADIQPVQAAKPYVPTTTPAIPNPPLPVEGCASFSNYELAASLLVVPYILQKFIPFAPNGWKTYWFLFVLSGVPTAIGYWYLKSKFGKPINEKLALPNRGLEYYLDIKDKALRDKYVLGGKKIPMQVFHDAYFDKKIEFKGDILDVLEYRHDWASFEFTPELFRYVFMNLIPDVVLHSQSQDEEQVRDHYDRGNDFYSWFLGPRMIYTGGVVTDLTREETLEELQDNKLRLVCEKLELKEGDTMLDIGCGWGTLATFAGKNYGVDITGVTLAREQTKFGTERLRQNGVPESRGRILCMDYRDIPHAEGKYNKISCLEMAEHVGIRRYSKFLKEIYSLLSDDGIMVFQVAGLRTCWQFEDLNWGLFMNKYVFPGADASCALNWVIAQLEHANFEIKSIDVLGVHYCATLHRWYKNWLSNEEKVKAKYGDRWFRIWAFFLAYSVIAARQGSSSVFQITCHKNLNAFPRILGVPSHTSLHAPLRKIEPVVSHTEMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFW1</accession>
    <name>A0A1E3IFW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_07042</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028978.1">
        <property type="nucleotide sequence ID" value="XM_019179060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFW1"/>
    <dbReference type="GeneID" id="30196253"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002669">
        <property type="entry name" value="Chromosome transmission fidelity protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="15"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODN87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="875" mass="97148" checksum="95EA84A5E24B0D7C" modified="2017-01-18" version="1">MTLQPDLPAPALPTPETFPFPYPTPYGIQVDFMRTVFRAIEDGKIAIVESPTGTGKSLSLLSSTLTWLTQHTHRLDTHTETSLRARLQAEDPDDPAWVIEHTVKSRMAELRRERELREERLGKVRERERKMRVKEGMGAFRGGGKRVRVGYDGQVGSETKELGEDDFLPEERDEPEDDGMYLSKEVRELMSKFEPVKSKQVVDEEEEEDVPKIYYTSRTHTQLRQLTSELLKTTYGTAVSSPDEGNSSDSINISLVPLGSRKQLCINDKVRAMAKSGGDERLNEACLDMQKSGKARCEYLPAKADEVKLLDARDSILATVKDIEDIVIAGKKACVCPYYATRRAVRSSQIVTLPYNLLLQKNAREALGINLKDQVIVIDEAHNLIDTLLSIYSTSLTSSHLTTAISQLEQYLARFKSRLKSVHALWIQQVLTVLQGLVKVCDRFIADAKGTAKVEGGKPAFGKPKTEVLGANELMDRVGGGSDQVNPLELVKYLKESKLARKISGFSEHVAEKAALKESKTSRNAAARHASISSFHTVESFLLSLSDAKDDGRVILSLEDATKPAPVVTIKYVLLNPSERFREVVEEARSVVLAGGTMEPVSDFMNQLFPTIPRDRFSTLSCAHVIPKQNLLTQVVCSGPKKTEFEFKFGNRNDDNLFADLGASILSVVNMVPDGVVVFVPSYAFLDKVKTLWTKTGLLEKLEVKKQLFYEPQTSGDVETILRDYSLAISSSRRTGALLFAVVGGKLSEGINFSDGLGRCVIMVGLPFANVGSVELQERMKYVENIPGAARGGGGGRELYENLCMRAVNQSIGRAIRHANDYATILLFDKRYATPRIRNKLPKWIGEDVKVEQTFGGVMKGVAAFFRDKRERGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3III4</accession>
    <name>A0A1E3III4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029226.1">
        <property type="nucleotide sequence ID" value="XM_019178743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3III4"/>
    <dbReference type="GeneID" id="30195900"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="31977" checksum="B3A3998106C762F6" modified="2017-01-18" version="1">MDPLAPLPTLALPPQTLILLVGLPGSGKSTFASSLCQSSASLLTSDPSNPYQPLHASIQGGIRPWIRASQDDAPSRRRQEVEALVGWGLREGCNVVVDRCGFDPVQRSHFISIAEGINPQIRIYALVLAVSEQTLKTRLTSRESHPTITGGEEGLRVLGQMGKVWQPPTSQSGEGFHKVLILDEKDQPNGAEGWTEDLAREVVAKIEREGEQEVGERKDYKPKPREFGDGRGRGRGGYRGSWENGRGRGGWGGDRGRGGYARGGSGGPWRGNGDGWRGGYGRGGYHQSDSTASVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIM7</accession>
    <name>A0A1E3IIM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029258.1">
        <property type="nucleotide sequence ID" value="XM_019178775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIM7"/>
    <dbReference type="GeneID" id="30195933"/>
    <dbReference type="OrthoDB" id="10458257at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="15746" checksum="0A8A57C8D6A2FB5D" modified="2017-01-18" version="1">MIAEGGPRDDDSFLQSAEDQSLSSPSRPLSGDKTSIDTEQDLAPTVADGMPTDNVSSATREAIDAAVTDGIITYLSNARLSHAFKATVSRSLSILEHIPKTEGIDMMSSFAMDDLCQANASSKGPDGGAGRLLASASGRLRVALMYLKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJG0</accession>
    <name>A0A1E3IJG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thyroid hormone receptor interactor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029164.1">
        <property type="nucleotide sequence ID" value="XM_019178887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJG0"/>
    <dbReference type="GeneID" id="30196069"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="245"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="571" mass="63723" checksum="79644C9D57C2BB45" modified="2017-01-18" version="1">MSRIISLGAPPPRSSPSDARILGSSGYTSPSKAVKGLSLNDENSNEINGHGEEQDKEEEEEEEEEEEEMGMMVDSDMEETEDEEDDDRTVIHVEVRQKQHSRILQQPLMIVLQQFIEEEIARVQLGCELPGWQEVEILREHVDRVWVEEGVMGVESIQASEAEIQVHVYKASVDDLLEEFTADLDDDDDEEKVSAASVRSLPSKELDGVWDTLVYSDDIKARLLNYIYSTILFSECEVDFNVIAWNRVILLHGPPGTGKTSLCRALAQKISIRLSDKYRHGKVIEINSHSLFSKWFSESGKLVQKLFEKVTDLVEDDSCFVVVMIVDEVESLTAARAGAMRGNEPSDSLRVVNALLTQLDKLRTHKNVLVMTTSNLIDAIDEAFLSRVDLSEHVPLPPPRAVYSILSGCLREMGKKGLVRGCRVMDWQGAEEARRERKFKGGEGKGDDKKREREKAIGASLAELAIRCHAIELSGRTLRKLPVLAHARYLSSSSGEHRAQKIERWIDAMNKVVDVEAEKKEGPVSEFSGVANGVGGEKGKGHSRIGSMEKRDVGVLVGTKMRGDRQEHGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJL1</accession>
    <name>A0A1E3IJL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine zipper with capping helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029340.1">
        <property type="nucleotide sequence ID" value="XM_019178639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJL1"/>
    <dbReference type="GeneID" id="30195796"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="5">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="127" mass="13958" checksum="D6369620737F7442" modified="2017-01-18" version="1">MTQKNAALAKHKKELDKLETSLGETKAALDEAEQGREDTPERQSLISTLSSLQAQSTALQAELSAFGAADPIKYEKKKQAIETCKEGAVRWTDNVMILMQYAGGLGVESGQVRGFLEIDEDWDDLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK14</accession>
    <name>A0A1E3IK14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029333.1">
        <property type="nucleotide sequence ID" value="XM_019178632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK14"/>
    <dbReference type="GeneID" id="30195789"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="636" mass="66328" checksum="3EC10239AFF57EF7" modified="2017-01-18" version="1">MSFAAPEERYNNYNAYRPPTSSHGAPLSPDQRIHSSHGYAKPPTHESPSQVYQEHPLAPVPSHGYPPQSQPMTPLTSNSYPPAAQAGSYYTIPGQAQAQGEAIPSPPPSSANPVRPDTANSGSGEFAAPAAPTQTTEGGVPIVPVGVSGGKLFRCRGYGECDKVFTRSEHLARHVRKHTGERPFPCHCGKAFSRLDNLRQHAATVHSEQTGLNETMLASLGPIHAALSQRASKDQRRRGEVVEVPKNAVERRQSEYRTRGGSASSSQPNAAQGTAPPSQTNSPYTAYHDPQWASQPHSRPRTSGGYDYPYAAPDHQQSLGEDAGPSRRPGSAAGYGYQQDFYAGANGRSGSAAGPPPGEMGSLPYPYRPMSSQGRDLPVPTHYAESEPPASAHGPPESPMYANVPNPQQPAWSSPPTNHSAYPPHDAAAYPAPEGYTYSQGHGAYPPREEVYEYPPQSAAGWQGGYPPSHGSYPQGYNGAPQPDSPFQYNIGHPGAPGAPGAAAGAPPAGAEGYSYSSGGYDRKRRAEDDGDHARKHARHASGGQGTAAGNASAVSLNAALEASTGPGAPGAPGVGRGGAGGIDSWLPPTTERRGSLAISALLGSPKTVAELDGAGLGAGERGSPKEVDGKEGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKK8</accession>
    <name>A0A1E3IKK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 29 (Equilibrative nucleoside transporter), member 1/2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029418.1">
        <property type="nucleotide sequence ID" value="XM_019178511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKK8"/>
    <dbReference type="GeneID" id="30195664"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="476" mass="50693" checksum="A998BB2C1DA349CE" modified="2017-01-18" version="1">MLNAIRSLLTPAASQRPDPSEYQPVISGNPEEPIDGEELDDAVGSGATREVGEYERVKVYLCFWVLGAGVLISWNALICTFPLLISYLPADSAMRGSLSSILSTVYCFGNLFFLGLAQRHVSTASPAKRLHSSLLLLLVSALVLTYPLLPSLLPHFSPALLLTSLIIISLVLSLATAYLQSSVFALSSLWGSEQTLGVMSGQGGIAVLVSGIQFVLAFVGAIGKKENGVPGGEEASKLAGVGLWAACTLGALACFVASNYLQKQPKYTSVISGKASRASGEDEHTKVKGSTMKILSQNWEVNVAVAWVFIVTLSVFPPITTRILSTHVPTPRLLQPDVFIPLHFVLFNIGDYIGRTYLPAIPSLLLTSPKRILTLSLGRTLFIPVFFACNVTPRSIGNTPFINSDFLYLAIILAFAITNGYMSSLCMIVASSPSLNPRIKDEERDLAASLASFCLVAGLAGGSMASFGVSWAVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKQ3</accession>
    <name>A0A1E3IKQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029457.1">
        <property type="nucleotide sequence ID" value="XM_019178550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKQ3"/>
    <dbReference type="GeneID" id="30195707"/>
    <dbReference type="OrthoDB" id="10311516at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="40021" checksum="A68F348143EEB52B" modified="2017-01-18" version="1">MLPLTTLDVHEQAASPLKDELGQESDKTTETPDNSSPESIPPMEAEHHMINDWLSEQLRYHAIYAPPIFPMFLYTLFAITYGALASLGGRRPFIELLLVGSGLFLLGMRVQVHRRLDREIKEVAKSLKVALDGKEVGAIDLKWYRRATPGLTDCQTGTIFHPFPPSSEDHHQSPISLTSYPLMRKFASFPEKARIVAVCVFTPLWGDMLVTACGIDDTKVYALPVRIGLEVILTLMLGNMFVLFTFVVEYEYDRITGGPNQSSMVQESMEWNSLLWIQEHMGWWGVLVMEQTLGRDRMEDLMAAMREREKQYVDDRSTVLQGLIDQGCSAATERETFFSTVDYDLLNDEAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKR3</accession>
    <name>A0A1E3IKR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-fuconate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
            <dbReference type="ChEBI" id="CHEBI:37448"/>
            <dbReference type="EC" id="4.2.1.68"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.68" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029474.1">
        <property type="nucleotide sequence ID" value="XM_019178567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKR3"/>
    <dbReference type="GeneID" id="30195724"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="7">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="471" mass="52539" checksum="F5F6044C33020681" modified="2017-01-18" version="1">MSLKITNYSVHDVRYPTNVTGDGTDAMNKECDYSAAYIVLETGTDLKGQGMTFTIGRGNEIVCFAMEQVAKRIVGLELEPIFADMGKFWDFLVADPQHRWLGPEKGVIHLATAAISNAVWDLYAKHAQKPLWKLIVDFTPEEFVKSTSFRYITDALTREEALAILKKKEAGKASREKEVLERGYPAYTTSVGWLGYSDEKVRRLTKESLNQGFNHFKLKVGADAEDDLRRGRLIRSIIDDPANIPKDRKPISPESIAGKNAGPTGCVLMVDANQVWDVPQAIEYMKKLEPLKPWFIEEPTAPDDVVGHAAIRKALKEVNIGVATGEHAHNRMIFKQLLQLDAIDVCQIDSCRLGGVNEILSVLLLSAKFGVPVCPHAGGVGLCEYVIHLSLIDYICVSGDMERNVLEFVDHLHEHFLYPVSINEEGRYNIPLDPKGGYSIEMYEKSIEDYAFPGGAYWAAVARGENPEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM18</accession>
    <name>A0A1E3IM18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029549.1">
        <property type="nucleotide sequence ID" value="XM_019178393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM18"/>
    <dbReference type="GeneID" id="30195539"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="264"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="423" mass="47122" checksum="D77277C42403B06E" modified="2017-01-18" version="1">MAPKLTGFPGNSRVRRVLAAAALAGVELEHDKSWSFQNEWKTEEFLQKNPFGFVPILELEDGTVIRESSAIAEYIAEIGANQTLLPSDPKGKAVVHSWQATADQEIFIPSGVANGMLAGRIPYHKPIFQAVVDKITSRIQVINDILLDQTFLVGERITLADIFIVTALTNIFTSWFDAAARAQVPNVVRYVNTVVSHPKLQAIFTPLEFTEKAPAPQTASKPKADKAKAEKPKAEKAPKAPKAPKAKEPEEEEEEPLVPAEVKVRNPLDDLPKSPFNLEDWKRAYSNLDTRGPGGSLEYFYKNFDYEGFSIWRVDFKYNEELTMPFMSNNQVGGFFNRLEASRKYLFGSVGVLGKTNDSAIAGVIVLRGQDAVPVVNVAPDWESYSFTKMNIENADEKAFFEGSMAWDLVENGREWADGKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA9</accession>
    <name>A0A1E3IMA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06431</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029646.1">
        <property type="nucleotide sequence ID" value="XM_019178490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA9"/>
    <dbReference type="GeneID" id="30195643"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="210"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="793" mass="86752" checksum="38093A319E7451DC" modified="2017-01-18" version="1">MAHVPASPTAPGPPVRHTRAPVVDNPYDVDLVVPYSIALGKKDLKNRTKAELEIKEGYEQLLRAIEGHGGFKVATKPGRAGKGQEEVWVFISASEEKVERLVEEERQMDAAHNLPTPPVTFPPSPATRLRLIYNVLTAPALQGGLGITPGRGRWSRVKSIMALHDEAADHQWIEKWTTGGDWKVGLTKGLDEDTQRSGGLGDQQPPPVHLYFDFLTTYTLSLLPISVISVLFYLFTPADSYPPLYAFLLSVYASVFVAIWRVKQRKFAVRWGTIGCESMAISRLRPEYVASLGFDEKKDLQAVDAIQAGNELKRDTKVAASIPVIVACGVGLGIVLMGIFVLEAFVGEAYDGYGKEIVPLIPTALFSLLVPQIVAGYGYLAELMVKWEDHPTPTGEEKSLTAKTFAMNAIVAYLGLFLSAYVYIPFGSFIMGHVQNKLAGQGFSVEKVGGSGNGTVQTETGPGSSARGTGIDKAAINGGRLKSQLFAYTVTNQVVNAFLELGLPYILRFINEWRAGKTTLREAITRRGSGPNGAGEKTPVTEDDVEKRFLDKVERELELPEYTLFTDYAEMVTQFGYVTLWSIVWPLAPIFALINNYIELRSDALKICKHVRRPVGDRVETIGSWLDTLGLISWLGAVTSSTLIYLFRPAPEGPSLGSQSANPNFPLPGSHALSHIVSTFHEHSSPANPFTSWINVHTLESLVPLALIALGASHGFLVLSWVVEGTVERVWWRGSWEERELGRLRAGGAGGVRSETSAVQEVREKVFAPEVLGGFWNGGEEGAREIARLIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMB4</accession>
    <name>A0A1E3IMB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mss4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029648.1">
        <property type="nucleotide sequence ID" value="XM_019178492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMB4"/>
    <dbReference type="GeneID" id="30195645"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19304" checksum="0785B228F0EE8ED6" modified="2017-01-18" version="1">MTAPYSQADILAALSAQSALPRTTPTYPFSSFPTPLLQLTNSVPEDKSESPKTNGRKVYCPREGCGSVIMQAGVGNWLDVPGAVLPDDPESPFPPAQPPHAAWHVPNGPFEFDNIGFSRPDASASPLPAHAPGYSAEKKVKWLICGECDLGPLGWSYEGGKDAWLGVERVRYGEGKKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMD8</accession>
    <name>A0A1E3IMD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Charged multivesicular body protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029597.1">
        <property type="nucleotide sequence ID" value="XM_019178441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMD8"/>
    <dbReference type="GeneID" id="30195590"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="204" mass="22327" checksum="A01482271D34D2DF" modified="2017-01-18" version="1">MSNLEKSLFQLKFTAKSLQRQAKKANKDETAEKNKLKQALAKGNTEGARIYAQNAIRKKNEGLNLLRLASRIDAVASRVETAVTMRSVTNSMGSVVKGMDKAMESMNLERISLVMDKFESQFQDLDVQTSYMESTMSDTTAVAMPQDQVDGLMQQVADEAGLEIQHGLGEASVPAKEPAVSEGSANKEEDGMLAQRLRALRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMI8</accession>
    <name>A0A1E3IMI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029441.1">
        <property type="nucleotide sequence ID" value="XM_019178534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMI8"/>
    <dbReference type="GeneID" id="30195687"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN89156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="359" mass="39020" checksum="40ECD944EE993C2F" modified="2017-01-18" version="1">MSAQGALSIVPAGVITGDNVRKLFQYAKENKFAIPNVTSSSVVNGVLEAARDIKSPIILQLSQGGAAFFAGKGLANGNQEASIAGAVAAAHFIRSVAPAYGIPVVLHSDHCAKKLLPWFEGMLEADEAYFKEHGEPLYSSHMLDLSEESKEDNIKDCVFYFKRMAKINLWLEMEIGITGGEEDGVDNSSVDNNSLYTQPEDIYDVHAALAAISPNFSIAAGFGNVHGVYKPGNVVLRPELLGKHQEYTHKQVKGSEEKPLFLVFHGGSGSSKEEIATAVVNGVVKMNVDTDIQYAYLAGVRDFVLAKKDYLMSQVGNPDGADKPNKKQYDPRVWVREGEKTLVTRVKEACEDLGNVNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS9</accession>
    <name>A0A1E3INS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity iron permease CaFTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029785.1">
        <property type="nucleotide sequence ID" value="XM_019178347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS9"/>
    <dbReference type="GeneID" id="30195493"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="424" mass="46232" checksum="F21437150113E58A" modified="2017-01-18" version="1">MAKDVFSVPIFFIVFRETIEAAIIVSVLLSFVEQLMLTGNLSANDMNKNESTAPSDGEAETDGSISSGVDDKERRAKLVKRMRIQIWAGTLLGLFIALCIGAAFIAVFYTKLDDLWAKTEQLWEGIFSIIAAFIIWIMATAFLKMDRSRIKWRWKLAAAFDQSQAKVVAQENMSDEDRAAAKAEGKSGKWALFLLPLITVLREGLEAVVFVGGVSLGLPATSIPLAVVVGLIAGFAVGYLIYRTGSTTTLHWFLVGSTSFLCLIGAGLFSKAIGYFQYYHFSQGVGGDVAETGDGPGSFEVKGNVWHLTYGNPETGSPTTNGGWQIFNAILGWNNTATLGSILSYVFYWILVALTLVVFKWKEGRITFFGKASASHARRLQIREEFAAANANAGSKEAEVEGEKKINPDAETPSEERHVPALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP83</accession>
    <name>A0A1E3IP83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029645.1">
        <property type="nucleotide sequence ID" value="XM_019178489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP83"/>
    <dbReference type="GeneID" id="30195642"/>
    <dbReference type="OrthoDB" id="10312237at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14262" checksum="ACD052245A1FEDCC" modified="2017-01-18" version="1">MSMSGDFDESEDGNQGKRVRWVRMCNLSSKPAICQCVDELVARQAKEVLSTAYSLGFVVRFDRRFSSDDGEVSLHLRVSPMVGHQGRVICFEADGQYFHPRYDAPSRLTEKLLGLLCGFSLPSLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQA0</accession>
    <name>A0A1E3IQA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029820.1">
        <property type="nucleotide sequence ID" value="XM_019178101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQA0"/>
    <dbReference type="GeneID" id="30195246"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="470" mass="51934" checksum="FBCE12CC02FD10CD" modified="2017-01-18" version="1">MGLRAMRSREEEEARELEAEKAGPDPYQVQFEPGENINPKNWSVLNRWFLTGIGSLLVLNSTFASSAPSGIVTDLMEYFTFSQEVAILTISLFVAGYCVGPLLWGPLSESYGRRPIFIIAFFCYTFLGGTFASAPLTNSGALLADIWDGKNRRTAMNWFALAPFAGPSIGPIVGGYIFVAGASWRWVFWTLTIFAGVCLVLVVALIPETYAPKVLANKAKRLRKETGDDRYWAPLEKSDTSFKGRINDILLKPFIILAKEPMLQAVTLYMSFVYGVVYLLFEAFPFVFVQIHGFNMGENGLAFLGFFLGGVIAVMLFITVFEPRYQKAALKRTPAPPTPETRLEFCVISGVSLFVAMFWFGWTAYPSIHWISPVLAAGLLGIGTLGLFVSLFNYMVDVYLWSAASALAANTFGAVFPLFATQMYKKLNVHWASTLLGFVALVCAPIPLVLIKFGPKLRARSKFSANKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRU4</accession>
    <name>A0A1E3IRU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029969.1">
        <property type="nucleotide sequence ID" value="XM_019177930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRU4"/>
    <dbReference type="GeneID" id="30195066"/>
    <dbReference type="OrthoDB" id="10366016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28553" checksum="B5ECCA087FD03503" modified="2017-01-18" version="1">MSKRPISPPADGPQEEGRDEPHQSRLWPPISQDSSNEAVTKIISADDVELYVPEHLLRSHSVVFRTMLNDIPSPPPASGNSHPIELTDPKIEGHKTLHLFLAIVTGEDLKDAVARDQIVGARGEMLLAVMRFAEKWDCPIATRLLTFSLMELAGKGLHQRVVSRWDIFVIAAQMGLPEIAAKVIEVYRADIASSDPEISSYPPPSWPIFLGAYPEFAISSLKPEAWGVIPSHYLHALYRASTTTALGDDNQDWCENCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS37</accession>
    <name>A0A1E3IS37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_05934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030046.1">
        <property type="nucleotide sequence ID" value="XM_019178007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195146"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1171"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1209"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1258"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1356"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1389"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1486"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN91420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1500" mass="166646" checksum="CE71F1A0AD0E1905" modified="2017-01-18" version="1">MESDIDPRFLDDEGDVCRVCRTGAEEDLPLVYPCKCSGSVRYVHPDCLKQWVAQSQKKHCEICGHKYTFTKVFPSELPSTIPPTVYARQALLWVRRQILFVLRMWLVIITWLVALPATNMTVLVAMNYATDHIGDSPQSLSINATTTDNSTTSSANFSSTVTSILLNPYSTAYHFGKDSYESWLKGDENTSIGYVLRGQILSLSLAAVLIGLVLLREWVQQHNWAEAEQPPRHVEPDIDPEEWFVINGVARRQSEMISRVLETLRGSNNGDNTGPFFPDTDAGHRDRAEWWANRRQWVMALPEPERTTLLAIVEVMERQHRGEIPLGDDELEDEESDDEGLHDQLQVAQNVPIPQTPQEALFADETFIPNDGNNAEGLLSFSEYIALRRVNEGKAPTTDPASSDDSSEDEIRYDNAMTAEQADQDGPSRKRKADDVGFDDEAARPRENITDALAEYRRVHTQREQAQAHDDEEQDDLLQAPFRPAWSRQASGDKAQDQRERVAYRAPELLRNQSDQDQGTAEGSGQNGYEAQPIHPQPPQPLFDGFGNDGEGDEDEDDDWEDEPDDRGRLEAGNEFDLLLDAVPQAPGPVVNGQPAALAQIPGLDLGVRVLGANGEPIHLPPGNVQVVPPQDVAFGDEEEDMWDPEDWNGILEVVGLTGPMAGLYQNFMFAFIIMGGAIVILVGLPMLIGKLCLSLDIIRSILSICGRVIHLVRKVTDPVVDIVFEIVKDVVLLPLLNSGKAAEKILAKKLGLQVSSRFGSQGLSGLPSVPSTSSPMVQKLGDHLAALGQYSYDIYESVMTFQREIGTRQTVSGRAACVGAGYGLVAEVVAVIAIAGEAGIGGVAGDMAATIKEHTNFIKVAMFMVLELVAFPLGVGFMIDLSIVPLFPGATAMSRVHALRTSPFASSFIDWIVGSMFMFSFSSLLSQVRKVTRRGTMFFIRDPGDPSFSPVKDIVEKTTMHQLKKLGTSVLMYSLVIFGMFGVFPWALSFLPGGLLPLKMEPNYPLSSIPFDLLFLHLMLPPSVDLFQPRLRAKRLFKLWWKKTTTQFRLTNFVNVAPHPDERTAPLTVAEKTLWPMWDVVCQLAFGKYDNKETMARVPASDSVVLVPVEERRVEGGVFIPLDSKGVPENPQDKLRLLKQDKLSREAGRLPMSDYGIVWLPQYWRTRIHMFLATALASISVVIASATFIPIIIGRMAWKWSGFEVHDGYSWFLGAYIAYAAYALGRQARKYINSLNRADRLRQSIFSRRVKRTVRRYCAGAFGVSMMYGLVPVLVGAVLESYLGVFFGDKHLPGRVVHFWDIWALGTAASSLLTGVILVVNRLGRFDSLSAIATQFREPAAKDFSSTASNIKTPVLVCISAIALPYAIGISSLMVLPPDVNMDENNAFLFRCVIIPISFAFLLITSFSQYLVSERETIRQKVLEAEYVLEERVENYEPGSEESSAEERNPLDAADLPPDIRLQLERYQQAVAAEPPRVLNRGDVEIEDGSDEGENWEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITV2</accession>
    <name>A0A1E3ITV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029962.1">
        <property type="nucleotide sequence ID" value="XM_019177923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITV2"/>
    <dbReference type="GeneID" id="30195059"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="402"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN91336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="629" mass="70163" checksum="AE4DD8CA685E4C24" modified="2017-01-18" version="1">MAPSKQKGAKLSTDPLKQVSKYESALTADTFDPNPLLPLIALARHDDPQIVHKAVWALHRVFIKLIADGKVGGLSGDLVNGAEREQVVGEEGEKAVKAWVRERLLEYVQVLAGLMRDEESALRASSVPLLFSLLPSLSASISSKPIIHIPYFRLILNYLIFPRPSLRGAKPKTKSVGWKIVAANQVADADGVLPEDVAKVVVDDFWAPHDDIRWAFFKEASSLIQGHTSVIAHPENVLLQVLPLNNLPREASDINAFYVSAFSTPPAKGEGEARPVKKSRSVKAKKGKAKAEVDALPDWMKDYESSDSESDSELQAGSKKRTRTSQLSLHASIYSIVSQTTQFTALWESVLFNLRLDEGWTRKILVALHGEQGILSFWKKERRLRVADWLGSLVDQGGVVGMLAMNGLFVLMTEYNFEYPRFYERLYGLLDKDVMHVKYRARFFRLLDIFLKGSLIPAALIASFIKRLSRLALSAPPAGVIIILPFLYNLFKRHPGCMVMLQRQSGKVEKSEADPYDAEEKNPLKTRAIESSCWELSTLQKHYLASVSTLAKVFGEVFTKAEYDMEDFLDHGYGTLFETEIKRKIRHPPALSVALETGAKITIFPDGEKKEGEDGGEGEEDVVAELWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITW1</accession>
    <name>A0A1E3ITW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030136.1">
        <property type="nucleotide sequence ID" value="XM_019177752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITW1"/>
    <dbReference type="GeneID" id="30194886"/>
    <dbReference type="OrthoDB" id="10324160at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="492" mass="54696" checksum="F758FD65FA4CD104" modified="2017-01-18" version="1">MSLPAHHARLKCIHQPPPEHGPIFHPYRFVVDVPRGQSDAGAFGMWKQVQFLHYSSLDHNNIPTRRVGLARRGMLGKDAKLEITVEPLVKQEPQHWPNDLFDSARNEPYPYAEWFTPQGRIADPGCEEWIQEIKFHEEMRDAMGRPTRYVKHKEGKNNVCFRHKVIPTEWLNGPPVSSAAASHPSTLPTSATRPPSLYQVPSPSDTNVRRGPEPHQSSTDSTREAPGLAQNFQLRGPPVPHRLTPTAPRRVLSSNNRSPSSGSQKRDYGRSPTRDPPAPKRLKFNHGDSPQNLREESLRENPIWGRPEARGKQVIQSTRTGPHLSYAVPTPTPPSPPVSTVMAPVTHSAQALVEADAPKPTHPSIHDLFSRSKQSTPVPPTPPLSAALSLPAAPPSRPLTPPLPPALLLPAPTSTASEPDADLDKIVHDPKSVRTGPPKPSAPVQERLAYRQAQLEEWEKMVCQFPDLREIIEWQISKVGKQLEVLRGEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVU3</accession>
    <name>A0A1E3IVU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030367.1">
        <property type="nucleotide sequence ID" value="XM_019177616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVU3"/>
    <dbReference type="GeneID" id="30194747"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46534" checksum="2B8B356B4EF8D079" modified="2017-01-18" version="1">MSVFSCANGHTKAILVYWVSYQQAWSPLSDSAPTSSIPVPVSTLSSTYSASPSLGLPSNDEVSFSYRSRFAVITLATAWIKNSGQFYAVRCLLGAVETFSMPGLSYVLSRYYRRHELTARFGIFMLVAIGCSQGFGGLLSGALVDMGSIGNVMGWSLIFLEGIITIGIAIFLIIFFPRDPFTTRMFTDAPPGEDTKEPISWAGIKKMSFLNLNMAAYCCMYIANCMSSQGLAIFTTSILQVIYPDASTKPIQYLSVGPQVVAVFIFIGVLGCFAASRPQRQGYICPHIILVSTAQQTSSSYASLRYFALFIVTGGGYIYATCVLGWAMSNASPDTTRSLTGALVTGLGSIGSIASTWSYIATDAHTGFRIGNALNIGMNVGTVLVCLGLMAYQKKENQLREGGGRDYRLLEPQPEKLGRHHPAYRYKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVW7</accession>
    <name>A0A1E3IVW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030325.1">
        <property type="nucleotide sequence ID" value="XM_019177574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVW7"/>
    <dbReference type="GeneID" id="30194705"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14573" checksum="BE5A562FB2E3B2F8" modified="2017-01-18" version="1">MPLYELFCIAVHNPVSSVNLRGIVNTVSTQVHQSGGVVRDLKNMGLNLTLPQRIRRMRQYYTKGDHFTMAFDTSPIVLKRINETLRSDPSIIKWTVLKRAQKVKDLAAPRNPSIEFQEIGVADKHTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW09</accession>
    <name>A0A1E3IW09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030365.1">
        <property type="nucleotide sequence ID" value="XM_019177614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW09"/>
    <dbReference type="GeneID" id="30194745"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16394" checksum="EEA56CC07CD01927" modified="2017-01-18" version="1">MIKDLIPNLGAGGDRIILAVIAPGTIITIITVIGYLGGSEAGIEQAAVYLLDIEPFQIFQIERRLHQKVHPALKLFLWDRIASASSPAYKVEYVGIVRLGMAVKMSQRDKGRLVPETYSFLTSPLFDGTSMEPLHEYGSHFRRYLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXU9</accession>
    <name>A0A1E3IXU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cu2+-exporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030524.1">
        <property type="nucleotide sequence ID" value="XM_019177371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXU9"/>
    <dbReference type="GeneID" id="30194497"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN93419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1054" mass="111054" checksum="525FF05D6342EBC7" modified="2017-01-18" version="1">MPAPLNSPPRGQRSSSNGGLLHSIIDTIPTPITSLFTSPKVGTVLLEGDESPFGEGKGLDGGLVPKRVELRVGGMTCGACVASIESSLKQPGICTVQISLLAERGVVEYDPSFIRDNGQTWTDDLIAEEVEDIGFEATVVEKSEVEEVELRVYGLENPSVVTNLLERTGSIAGVHSAICPPPYTHLALSHSPLLASLRVIVDTLSAAFPALNFLPVSSNNDSQIASLQKHKEAALWRRTFFTSLFFAVPVFVIGMLAMYLPTWLMGWTMWKIVTGVYLGDLVCLGLTIPVQCWLARRFYTNAWKSVKHGSATMDVLVVLGTSSAFSYSVCAMFFAMFSDDDEYRPQTFFDTSTMLITFVSLGRFMENVAKGKTSAALTDLLSLTPSSATIYVDPPTEGELPNSTDPTRKIPTELVEVGDVVLLVPGEKIPADGNVLTGSTSVDESMVTGEALPITKKANSQVIGGTVNGLGTITFRVTRAGADTALSQIVKLVEDAQTSKAPIQAFADRIAGIFVPIVITLSLLTFAGWMVISLCTSSDNLPGAFHSPGVGKFGVCLKLCISVVVVACPCALGLSTPTAVMVGTGVGAKNGILIKGGKALEACKDVKRVVLDKTGTVTEGKMALTAVAWVGKDVLGQSALDTAATLSMTTAASPLQRHTVLSLLALAEARSEHPLGVAVAADGREVLSKAGLSPPNGEVVELESHTGQGLEALVKLSGGAVQERIRVGKAGFVLDSDSKSSEAFTENQPTMPEEILEFEQEQMNLARTVIFVSIVRPTGSVPVLALALSDSPKATSAQAIRAFKAMGIKVTMLTGDATATAQAIARQVGIDEDEVYSGVSPQGKARIVKDLGEMGGGVAMVGDGINDSPALVAASLGIALASGTSVAMEAADVVLMRSDLLDVVAAIDLGQQIFKKIKANLVWACCYNVLMIPLAMGVLLPWGIHLHPMMAAAAMASSSVSVVMSSLTLRWWTRPISSISPKDSYQGAQSGYTSLILDAKDAVLNAVDGIVQFAGNKLPILQRFTGGRRGSAMSTAEYEAIPLDRAHTPGSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY79</accession>
    <name>A0A1E3IY79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030613.1">
        <property type="nucleotide sequence ID" value="XM_019177460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY79"/>
    <dbReference type="GeneID" id="30194586"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="137" mass="16139" checksum="69C36E83DDE3E378" modified="2017-01-18" version="1">MCKHILNAQVAIRAPCCKKWFDCPECHAESQDHELTRTMEMVFLCKKCKKAFRKDMSEYEEADEFCPHCDNQYVIEAKEAKPMLGVEGEDARMDNRMLKDDREKEKPERSVFNSRDVSDKLDTMPLYQLNPKQQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J099</accession>
    <name>A0A1E3J099_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030486.1">
        <property type="nucleotide sequence ID" value="XM_019177333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J099"/>
    <dbReference type="GeneID" id="30194455"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="176" mass="19278" checksum="EF1F1D5EB1D18568" modified="2017-01-18" version="1">MIAFTPPTTSTRTQQLPTSDPFRQPLNAAALHHSLAPDFSLRNAGIFPIKRTTVNKGWCPPKTPPTNTPPILRSHPEGDVPQYSIGLMYARNVVLFTGQANVQPSPDTLPLMKPPSLPAVQGQGTAFIQAIDSDRPGVKFFQSIVDTIDGENPLTILSNKRHNGREIIWRANFGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J195</accession>
    <name>A0A1E3J195_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 16">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_04771</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 16"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030912.1">
        <property type="nucleotide sequence ID" value="XM_019176880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J195"/>
    <dbReference type="GeneID" id="30193984"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="19">
        <location>
            <begin position="332"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="709"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN94633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="891" mass="99048" checksum="B7E6AC687C94B005" modified="2017-01-18" version="1">MASTSFRILPREAACSFCNGTDAVNPEGRQERMITCSSCGRSGHPSCLGMATSTLVKRVMMYDWHCQDCKTCEECRTEGDVAQLLFCDSCDRGYHGYCLNPPLAQPPNALWHCPKCSSPPIPTALPRSHKKKIPNPSKAGAARPTPISTPSAPRPRGRPPKQKKPLKDDQAVFADSRIKVKIPNPNHRAPTEERATPMIVRLRVPSAKRPVEEETEEEKVPYGGIITGEDADTSRTKPQADDTERYEKARKEAEFKMGGPMPQRGNSVVPGSPMATPPPATGGKFTPAKAPPARPLRDRLLQQSLPDAFPFPSTPGPSTPGPPTASPWTGGTNLDKIKTIRFGTFDIDTWYSAPYPEEYAYVPDGRLWLCEFCLKYMKSGFASTRHRLKCKARHPPGDEIYRSSTISVFEVDGRKNKIYCQNLCLLAKMFLDHKTLYYDVEPFLFYVMTEMDELGARFVGYFSKEKRSRDNNVSCIMTLPVRQRKGWGQLLIDFSYSLSKKEGRVGSPEKPLSGLGAVSYKSYWRISVFKYLAQTSDPAKLTLKEISKGTSMTIEDIYTTLLSENMINILDSAPLPTPLLSSSARRGRGRPPVRRKGDPAASVEPEDDHGHTEEIVKIPKKYEILVDMPHIQEVLERQKKKGHLKLEPERLKYHPFIVARQSEKGNDGEGEDEEEEQEGEEVEDAIVRFAPRLVPPPPVIRVAPMTPHHRSHARQAFPDTPTVQTPLVAPPTRSLRKRKSDVAETPQRALRSRDSKTSVAEMLGDESGKGVERMGVPNGVVMDGQEAMDVDELPLAGGNDIPIDPALLFDDDTPQGAQFSAPHDPSALAFTQVNYPTHNSDFGAGAGGMYQSEVYGYDEDAEGEDEDAEGEQWVEEDEDAEGEEWDEDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N6</accession>
    <name>A0A1E3J1N6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide synthase Cps1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031048.1">
        <property type="nucleotide sequence ID" value="XM_019177016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N6"/>
    <dbReference type="GeneID" id="30194126"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="482" mass="55375" checksum="F53FF0CEDE592E48" modified="2017-01-18" version="1">MLYLTADKFPVFVPFGVIGFYRYLWYCIRLLARFTYRPIPLPHTPTYVASEDVTIIVPTIDAGEEFKEAARSWLVGNPKEIIIVTENKMAPPLQDLANAVDPEKIRVLTVPAANKRLQMAHGIRNTSTDIIVFADDDAIWPPQLLPYVLACFEDQQVGGVGTSQRVQPCNERMTIWEVLAAFRLTIRNIEIASSTHIDGGIPCLSGRTAAYRTIILKDPEFLHGFTNDFWLGKYHLNSGDDKFLTRWMVSHGWNTYVQVCKEAELLSTMKPNWRFLLQVLRWTRNTWRSDIRSIFTERHVWTKHPYVAYTMIDKFINPFTLLVGPCLVIYLIVKSTRSIDDGGYHLPAWDIVVSYLVWLMITRTLKLLPHLWYNPTHIIYVPAFILFGYYFAIMKLYAAFTLYQTGWGTRTGIGNVTEATEAAEKEQLEARQRQLDAQQQHPPHQHGAAQVYGGQQGYSDQGQGYAQYNQQYPQEGQREPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J227</accession>
    <name>A0A1E3J227_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_05027</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030707.1">
        <property type="nucleotide sequence ID" value="XM_019177126.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194240"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000064">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1021"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="195"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="990"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="847"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="944"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="964"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="967"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODN94176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147358" checksum="50DE1F3F2AF371BC" modified="2017-01-18" version="1">MSRQPDPFDDLLGSPPLPTSAAHHDPFEDDHTPDLFSPNTAASHRKVPTSSTSAQPYALDPFFDDDDEYPPHPQPGYASSGYLGPSTSTVNVPKSSYGHSDASMVPFADSGVAPAGFAGPASARSYGDDPFGDDEGPSAYAFTAPGAAAVSNWARPRRSRWQKFRDDYLTDVDWTMGLNQLLRRKSKFDGMPREIALNDPEGNRVKGFENNSVTTGKYGPITFLPKFLFSEFSRSANLFFLFTACIQQVPDVSPTGHYTTIVPLAVVIIASAFKEIKEDFKRHASDRSLNYSTTQVLVDGQFQNRPWRKIRVGDIVRLEANGFIPADVLLISSSEPEGLCYIETANLDGETNLKIKQAQPSTASLTNPQSVSLLRGHLLSEAPNSSLYTYDGTFHLSSSHPGAAPTKIPVGPNQLLLRGAQLRNTEWVYGVVVNAGHETKLMRNATDAPIKRTSVERQVNRQILLLFVLLLILSLVSTIGSSLRTWIWDTNSWYLRLGDENKNKARQFIEDFLTFIILYNNLIPISHVLIMTMEVVKFQQASLINSDLDMYHAPTDTPALCRTSSLVEELGQIAYIFSDKTGTLTRNEMEFRECSVFGTMYAQVVDDAKRDQGQKNFDVLRERAEEDSEEGETLRQLQTHSLLLLSICHTVIPEERHGAMIYQASSPDEAALVSGAEMLGYRFHTRKPKSVFVDVNGSSEEWEILNICEFNSSRKRMSTVVRGPDGRIKLYTKGADTVVYERLAPKQEFSEPTLVHLEDYATEGLRTLCLAYRDISDEEYAQWVQMYDTAASQLSGRADALDRVAEVIEQNLQLLGATAIEDKLQEGVPDTIHTLQQAGIKVWVLTGDRQETAINIGLSCRLISESMNLVIINTDTAAETSELLNKRLFAIKNQRMGGDTEELALIIDGKSLTYALEKECSEVFLELAIMCKAVVCCRVSPLQKALVVKLVKRSTDAPLLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADVAISQFRFLRKLLLVHGSWSYQRLSKLILFSFYKNITFALTLFWYSWFNDFSGQIAFEGWSMSYYNVIFTILPPLVIGIFDQFVSARMLDRYPQLYQLGQQNYFFAPITFFYWVGNAFYHSVVLFAFSVLVFRNDLLATDGRNSGLWVWGTTLYLAVLLTVLGKAALISDVWTKYTLAAIPGSFIFTMVALPIYAIVAPLLNFSLEFTGIVPRLWADPIFYFVLFLFPIICLLRDYVWKYYKRTYHPESYHIVQEIQKFSLADYRPRQEQFQKAIKKVRATQRMRRQRGFAFSQTETSNQDQTRLIRAYDTSVARPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Q8</accession>
    <name>A0A1E3J2Q8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030772.1">
        <property type="nucleotide sequence ID" value="XM_019177191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Q8"/>
    <dbReference type="GeneID" id="30194309"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="200"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="853" mass="89444" checksum="2EEF640B5F3A7274" modified="2017-01-18" version="1">MHHGHSPTQATPKPHPSVLRYAAPPQIPLTPTRRIDPAPAPDSADPQSHSLSPDPPSPNPTTISLTSTTASSSQPVPPSFAASVTHPAEIGLGLLHGEEQLKNALQSKDRMFVLVLAKELEAFIARVANGALTASSASGGLAATTSTLAALGLSAPLTVTPSSKFQRMLVYKSAEWYGIKAVPGPDGSMIIGVLGTFNDKSTSLRLSDLVPAAPSPAQKFRIMQRTPASTQNASAEGSSSSSLSDTAASNKLKTLEEREAAYAVAREKIYGKAGETEESSAPQADEPEVSANRAAAALEDDIDPVPRRRYGPSSAPYEVIYASLYHPSSGNHTPSPAPNMLDQYGQQQPRVDPMYGYQPANMDYAQFSQMDTNGHSAGAGYHQGTQTAYGYGGYSDGQYPAPQQPYMVPGWQPSAGYPQTVNDQQQQQQQYGMVQSQGGQWYQPTVNQPMPAIQQGIPYAGPTYGYSQPPQQPSQTYSNQQQRPAAMPPQGQSPYSHLVQPTPQRPHPHPHSSASSSISSRSYQSQSYPESSRPHSRGSNTSNRSAASSVRLGAMYPAGQAPGGGMGGGYRQKGMKQQGGLNGMTSLGLNEGKRGRGHSPVSLSSTTTASSSHSSRRTSSINVPPPSQHQLPQRPDWAANNVPYHPSPMVTPPNLGVSVAAPGMHGGMGLVSGQGPSAAEFPPLLRSGTAAEPMQVERAKMRPMTTPTVWGAGATAGGIGSPQMAPHVPSHVAILSAPRAQSQPPLHHHAPPAAKEEDPDFPRRVPAKAAPTLYDPSAPSGSLISGGSRPPSVNANPRTPTSSRSMASGGGLSPEEVIEAKLAAVSISAGVSIGPPPSRQNQAASYAKIARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V4</accession>
    <name>A0A1E3J2V4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031159.1">
        <property type="nucleotide sequence ID" value="XM_019176684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V4"/>
    <dbReference type="GeneID" id="30193779"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11338" checksum="BF87770D01CF79C8" modified="2017-01-18" version="1">MVCKKCEKKTSTLAAPDPFQPSSSTRKIGENKLLSARARASPYAKPGQGAKKGSINPYGNKCLDCKQNVHQNNATRCQKCAYKKGLCAICGNIVLDTKGYKQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J352</accession>
    <name>A0A1E3J352_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031259.1">
        <property type="nucleotide sequence ID" value="XM_019176784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J352"/>
    <dbReference type="GeneID" id="30193883"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000707">
        <property type="entry name" value="CAMK/CAMKL/CHK1 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="483" mass="53422" checksum="20377BB49A0043E4" modified="2017-01-18" version="1">MDHPRRFPTINGFRIGVEIGGGGFSKVFRAVDDTTNQLAACKVVNIFVNPNSVHSAPNVKELQKEVQVHKALKHHYVLEYLHHELVAKEKEREGLVPGLYILLELAVGGDLFDKIAPDVGVPEDLAKFYFAQMCSGMEFIHSKGIAHRDLKPENLLLAANGNLKITDFGLCAVFRHQGKTRLLSGRVGSLPYVAPEINGLPGSGYAAEPVDIWGMGVVLYTLLVGNTPWDEPGDNSPEFCAYRTGELLNYDPWTRIRGQARAILLSMLHLDPQQRITIEGIKQHPWCMTPSQLHREQIPEALTQGLRGAGMMTYADPTFNSGASQAYTSQRNQRMASQTGFFNKEESQFMRGTGNITQAGDLMSITTRFWLSLSSHNALQLLSSYLTSSLGAKNIRLTLSKDPSTGRVVEDGSAGGNITVVKLAGNNRMEGTFIVRGNDSLAAEGQSLVIMRRGKGSLLHWRSFWWSVVRAQELEQYIVRGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4X0</accession>
    <name>A0A1E3J4X0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031552.1">
        <property type="nucleotide sequence ID" value="XM_019176624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4X0"/>
    <dbReference type="GeneID" id="30193719"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="342"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="641" mass="74587" checksum="C4C7AE49EA4DEFA9" modified="2017-01-18" version="1">MPRLRASRLTFCLALVVLITYLYFYISNNNQGEDLESIGHDGIPRRHSSSLLNKGRSPHRSLANWWSQSIETEPVQVLEFTGDGLVKGWDSTYERLQQGDLTRAEKKQLQQAMEVHPILELMARSQEKWETLLASQSKTFPQAVTEYTRRYGRQPPRGFDQWWQYCKRNKVKIVDDYDQINRDIEPYFALSPEMFRKRVDDLTKTEHTSHITLSPTTASSLYGERAHSSRARWLFELLEPIAQYLPGEVTLSLSDHDLGSWLLGDDQKQAALEAIEEGRYLTEEEIKGFEKKDGRVSVKGTVSACPPGSPGWQRGVAKREGREIERPNKETSFIHDPLLTYDFCYNTDLLDDHGALSWDFVRDTTLRPIFQLSKNARNPEFLTTPLEAYENFTDPIAQKKYSPWEEKTINKLFWRGSSTGDSYSKRPDGHTWRQSHRPRLALMTQETEGVKDVWVQKGKIWEKESWSVAKLNEAYMDVGLTGQAHQCKKEDGTCDEMNQVIEFKARVLPEDSAKYKFQYDIDGNGWSSRFHRLIMSGSVVVKSTIYPEWFSDWLTPWVHYVPSKVDNSDLYDIMVFFVGTPDGSSPGHDDLARSIAEQARKFGEEHWRWEDMQAYMFRLMLEYSRLSAEDREDWSYQKRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J501</accession>
    <name>A0A1E3J501_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031176.1">
        <property type="nucleotide sequence ID" value="XM_019176701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193797"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="567"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="787"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1421" mass="155091" checksum="7D4ACA77FBAC964A" modified="2017-01-18" version="1">MAQPPPLPPRKPSQAPLESSSSISLAAPAMPRTPPPLPPRTPKSKVVPEPIVVPPREVVPSLQTPPSQSGDTGVTVAVTPATPKEERGEPVWASPASTGATSASSQEPHRVLGPGPSSSGSYPAAQTAEHLQSAAASSYEKAYSSVPKPALHTVTPNIPPLSTQQWVTFTSILVTLAYSRLSLLYLLVLAAGGYYGLATVHAQTRTNAPTSENIVTQKEKTMGSGDGAEAVGWVNHALYALFPLISTDVLTPFVDLMEDALSEEVPAIITSVRLDSPALGSQPLVLTSMRPLSDQEWFASLSQEDNPSQDHGSPRVGKGRRRAQSSTSKTPLTPGSRPGMFRSRSPSNASSPAESLSKTWSSSDVKINDDLLGNVRSRRLRDRLLHKITHRVPNQYSPSDGGSLSSPTSRGDDPDVEKDKEDGTRKRGGWRDEVEEDDPDAGQYVNYQIGFEYKRSEEAMQKGKGLHCLAFMGIGLKGVASAEVPVYIDVLYVKGTINVRLLLSPTPPFVKLGTFSLPTLPEFDIAANPLKKGSFNAMDLPLMKTYVKTSFASVLSSFLGPSTYTLDLDRLLLASAPSSLRLESVGCLHIILHSATDLPKADTMGSCDPYLEVGFEKSRKPVFSTRTIGNTMDPVWEEECFVLVTTDAIESGEILRIRSNDADRFSADDTLGAVLIDLASLIACSSSNGGGLQKRSDPFIADRPGMRASGTLNWSVEFCPLWQMPPEEASERLNASGQPITTPQGPEPSWLTWVKSLLPGDETDDEWLKNRKRRREDAKAWIAGKKEREVLEAEVGASETRLAGILRFHIHQCLDLEIEPTSGTYSSQPLSPGGGPPALAHITDRTSTENADPPSAYCEVYLNDKMVFKTRTKGVTPMPYFNAVSERFVRDWTKGKIVVVVRDERDREHATDPILGLVELDLQTILSKTSNITRWFPLNGGLGWGRIRLSLLWKSLDLSLPRGISGYEVSTVQIKSLAFTPVDGSDEEGKKTMRAVVRTDSDQRVVDLTPGPAHRDPGEELPTSPTISRSFSSLAPSNLTFTLPPKHHPTLAVMYRHSSSIHVSILAPRSKSRVGLRKRLGAGVIRLGGVVDGEGRRRVGVWQGGGDGGREEEDESDYDSDASGDHSQVTSPNKSYASISLHKTQSLSRIKTHMPKRSSISSRRSSRKLLGYLDIDWLLVPGISRAHKRIAKKDLRFGKVFEAWEAGRDLERDLSISSHIEEDDEEDDYESDEEDTEGAGNSKGTVSLDILDNQLGEMSDRRTHSHALHKRHKGVFQLKVARTGRYVKDKISSTVYSATNGGNSDLRAGYGRARGSDIVVEKEGLSTQTIAGILGWVSGNTFGAVTLTSYRGFWFSYACFLIPQFEVEASYAADHQERLNADGLYICCWDIITFIFLVAAHRSSVAMILLLVTLDLNFWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6F9</accession>
    <name>A0A1E3J6F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031690.1">
        <property type="nucleotide sequence ID" value="XM_019176280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6F9"/>
    <dbReference type="GeneID" id="30193371"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="85190" checksum="51BD1D32C9C5700B" modified="2017-01-18" version="1">MAAHDASSLRDLKNHIIGNTQNKIALAQDSRQLDRLLAVLHPASEPALLKEAAAVVASVANAPSTTIPLALLNVPARMLLLTREIITQPRHLHTFREALPHISRSLRNTIVSVADALWGDLWGAGPEGEIVSTGLETDNALQSVDDHRYSDILSSCLQHILEPAHAHTLLSLLRHHDPQVSLPVYHILTRLSAFPSHRQRILSWTTSLCDSPFPALGTTPSVPDNDYPFRSLVAGHVISTIERHQKYGSSQSTDLKVKEASLELLAALVQGETKLATLIRGHPGFASALHTDRNHVMEPTSNLFIQHLIALVHSSRRSMRLAALSCLISLIRSGPDGNVGSPEAHAVTQHLLADIAKLLLSDNLEERIKLNFLLAMLVADDPLAQASAFEANLPPLILQRLCEVPSKLSDMPRNLYFRSLESSLLALCALSTAHDPARVMISEYRPCERSQERQYMLPQLKYWLRSHSYGVRAAACQLTRALSRTVALLRTDMVDEELGPDIIAVLRRELIMGKSQRKNLMGEAAWIVEVSATAVLCNMVTDFSPFRSVLVQDGTLQLLVGLTKSEHQPLALNALWAIKNLMFHSDLMAKRDVISHFGHDWLLDLCSEKSPDSIRVQGLEIMQNILAEECPSTVSRLANDLGGVGGLQTLLDLLEACITGKPAFDGQTTTSSLRVLSNLALGDATTRTELLDRAAVLQCLSMITESPDVKSQVSAITTFQHLIESSTRPHTPRDAVVVALQSYQLVLRMRASAENSKKVDVVDKATAVLNLLGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6L6</accession>
    <name>A0A1E3J6L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031759.1">
        <property type="nucleotide sequence ID" value="XM_019176349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6L6"/>
    <dbReference type="GeneID" id="30193440"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="53"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="41303" checksum="B2853129142A9D8D" modified="2017-01-18" version="1">MSATPSPDRNRPLDDRKVTGYDPLIPPALLRHDLPVPAVASKTISASRRVTSAIVQGTDPLSRLVVIVGPCSIHDIDQAKEYAAKLRKGVQEGKWPGLEVIMRAYFEKPRTTVGWKGLINDPDIDGSFKINKGLRMARQLLGDINEMGMPVGCELLDTISPQFIADLISWGAIGARTTESQLHRELASGASFPIGFKNGTDGSVGVAIDAMQSASHPHCFMGINSQGMASIVKTSGNKDCHVILRGGTHGPNFAAEHVQKALSTMRTKNPDAFASIMVDCSHGNSSKNHLNQPKVAADVAAQIAAGEVGITGIMFESNLKGGKQSSDLGRGNLEYGVSITDACVDWEMTVDMLDNLNQASLTRRALLESRAGASGDAPAVKRLRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N3</accession>
    <name>A0A1E3J6N3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031760.1">
        <property type="nucleotide sequence ID" value="XM_019176350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N3"/>
    <dbReference type="GeneID" id="30193441"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN96514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="188" mass="21888" checksum="C331D46BC7340B82" modified="2017-01-18" version="1">MLSRPLVSTSRFLGTPPRSAFSPIAVSTRTMATVPPLPPFTAETAQKKVKAAQDKWNTKTPHLISPAYTPDSVWRNRDDFFSGTKSIEDFLTRKWQKEHNYRLRKELFAFDKDRIAVEFWYEYSETKDVSSQWYRTYGLEHWVFAEDGRMKSRQMSGNTISIAQDERWFKDRTDVNDGEVPPGHISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S3</accession>
    <name>A0A1E3J6S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_04269</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031800.1">
        <property type="nucleotide sequence ID" value="XM_019176390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6S3"/>
    <dbReference type="GeneID" id="30193482"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="220"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN96554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="50501" checksum="30A7D529CC8589AD" modified="2017-01-18" version="1">MSLSPVAALNSVIDRLSDLADTPAIDYKALVILSTWIQTGFEVYILQGHLDDETFRKAQVYSKDKTRYLLAQVVFNQLLGWGLIKTGLYAKLWDVSGTVVDSFGLGTNWVIVRSLVWVTILTLTTALPSIPWSYYYTFVIESKHGFNKSTKGLWIADTFKTYALVAALGLPVLSGFLRIIEYTGKTFVPWLMLFLVGIQLTLQIVYPLIIQPLFNKLEPLPEGELRTQVEALAGELGFPLTHLYVIDGSKRSSHSNAYFYGLPWSKHIVIYDTLIKDSTTEEVVAVLAHELGHWKFTHPTKLLLATQVHLFLTLTIFSIFINNRSLYSAFGFNPSLAVTAPQPFCIGFILFQLVLEPTDAFVKFLLNAQTRRYEYQADEFAVGLGKKAELAEALIKLHVKNLSSPHSDWLYSMYHHSHPTLPERLAAMDKYEEERVARVGKEGKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Y1</accession>
    <name>A0A1E3J8Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031904.1">
        <property type="nucleotide sequence ID" value="XM_019175991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Y1"/>
    <dbReference type="GeneID" id="30193078"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="23114" checksum="9760B53DA88A2D56" modified="2017-01-18" version="1">MIHAVLIFNTIGKPRLSKFFTPLPPLVQQSLISQIFSLIQDRPAGVCNFLDAPDLVFPTPQSLKDTKERERSSVGEKMAVAEDDDSRVIYRHYATLYFVFVVDGAESELGILDLIQVFVESLDRAFENVCELDLIFHFDEVHHVLSEIIQGGLVLETNINEISACVRGTTKNRKESATASNTLIPSVLSAPGGRGGSADGPRRWLAAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBG9</accession>
    <name>A0A1E3JBG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032058.1">
        <property type="nucleotide sequence ID" value="XM_019176145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBG9"/>
    <dbReference type="GeneID" id="30193233"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="48803" checksum="035B6BB16824CC12" modified="2017-01-18" version="1">MSNYPQEPEFQQAVNEISQTLEPFLAKNPEYRRALEVAQIPERIVQFRVTYERDDGSVSVNRGYRVQFNSALGPYKGGLRLHPTVNLSILKFLGFEQVFKNALTGLMMGGGKGGSDFDPKGKSDAEIRRFCYAFMQELSRHIGADTDVPAGDIGTGGREIGFMFGAYKKYRNEFAGILTGKGGDWGGSFIRPEATGYGLVYYVTEMLRDLDNTDWKGKRVLLSGAGNVAQYAALKVIELGGTILSLSDSTGALVATGDEGFTPEEIFAIADIKLQRKSLTAFSAGNKFTWHEGARPWTLVSKADVALPSASQNELNGEEAKALIKAGVRYVAEGSNMGCTLDAIEVFEASRTAAKSATDSGIAFYAPGKAANCGGVAVSGLEMAQNSQRLKWTPEEVDAKLKDIMVTCYKTCWETGKEYAEAGPVPSLVAGANIAGFIKVADAMKVQGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBT2</accession>
    <name>A0A1E3JBT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032200.1">
        <property type="nucleotide sequence ID" value="XM_019175710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBT2"/>
    <dbReference type="GeneID" id="30192795"/>
    <dbReference type="OrthoDB" id="2450055at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="78910" checksum="AA64426E7CC5E115" modified="2017-01-18" version="1">MLTRKSRSPRASLSIPSPNNNNNNSSSNSPLASPASSAGGKSLSSGYFPPVNRPAPKRVSKDEAFKNVKAMEGLLAAWNEYRHAVTLQGKAGRKLAGALRDMIGCMDKTEVAAQTMRPAAAMMDGVADLTIKLAKRVDKEYEDANADASKHFTLLAKESRSHDAYLGAIGKKHDKAEKAYRKASKTLSDTSNAHAGLQALKDTLSDDINRAHEDHQGLLGSKQAVLLLRLASSMGVVATSQFAYFSDSVRKAGTVYPDIEYFRALSDIRWHSALPPSLDEQHEDAVRAEIRLMKARVALGEMDIVGKDVWDGSKVTGNVATTKPASGEGKSVESKPNAKVAFETPPENAEKEVVPAPSVEKKPEPQSPYRKLAPSDLSKASSPPTATQHTRRPGLVSHASSDSQQSGRSGSGQAAAVIAPLALVRGSAEGKDQGEKKERGDMEQTVARAISRYSDNDFRGYPDPRTPPPISTESHPNSADRPNPIPLPYSPTRMSVSQMTAAIDPSRAARQSHRHSQSVSNTSSQHTLVHVQSHLPQHRHHPSISQTAAQAYKDEVYRQGERRAQGNEAAGQSGMTREEVVPRQSERRMQEESDNGRDRLGQYPYERVVERPRQSNRSRRVTMPPTYSEPAFVYHRPQPPISHEDFYYASSQSSGHGTHGSHRDRPAMLDPTPMYGETLYHRLPGGYPEGERVVERRPSGVIAPRPMRPLGSSAEMEEYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC23</accession>
    <name>A0A1E3JC23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032285.1">
        <property type="nucleotide sequence ID" value="XM_019175795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC23"/>
    <dbReference type="GeneID" id="30192880"/>
    <dbReference type="OrthoDB" id="2576549at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="30252" checksum="D29C2004AC958835" modified="2017-01-18" version="1">MAARTPDAPQGPTPEALALSASLFTSSIAAWIPANFGVPKSEVDKSKEFDRAFKEERGGRLGLGHPSIDDPKRLAAFSAGGGGLASLSKKLGKEKKENEGAEQQKGKGGDDDEEEESRVRSVGKTKKNTAQDLFGGKKKKKPEAPQVHPLARAQALSVVEAPAEATTPEFNSPPTTPESHVFPGHVELSPPSTPPNHMPTSSPGGSGIFPFQGPFALESPQAKRLMNERKERKKRELEEDDEESGTEGQKDSKEEGASPQKSKSKTQLRRESRKKAKVAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCA2</accession>
    <name>A0A1E3JCA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032349.1">
        <property type="nucleotide sequence ID" value="XM_019175859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCA2"/>
    <dbReference type="GeneID" id="30192945"/>
    <dbReference type="OrthoDB" id="10380855at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="43478" checksum="01DAEC8627F3F5C4" modified="2017-01-18" version="1">MVFETSNSTPPSLSIPSTHTVILFLYIYLNVVEIWWTLIWRLICASTFLLYRLLFNPEKKTVKKEFSPWKNPNANVVVSYKDFRRVEIPYKSYENKKVVFTRCSGKTPEKRILKGKWGEVHEEVKKPHAYHDNGEPCWDPECPEFDASQLRQRVLPELKKEDYLKEEAGFIRSFEDALIPEDIPREPAPIKPTRKRFSQHSVFIQTKLSASKLKAKWRLAKMRKEETRRMAKIEKSWAWEVSEIAMLKKDQADQKAEADAAEKLLAEARLPPQLPLFAKTGTEPGSHTVAIVVTPPMSSSTSLLTESSPSTSAPSTAHTTPVLSRASSMSSMSSFSTLFSSSTGPDRENKKRISFASSRSSAPVSETIRKAPCARAKAAKGARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JE97</accession>
    <name>A0A1E3JE97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032288.1">
        <property type="nucleotide sequence ID" value="XM_019175798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JE97"/>
    <dbReference type="GeneID" id="30192883"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="16707" checksum="C91982C333A274B8" modified="2017-01-18" version="1">MGQPSRKPLQRTLSQSSRESSTGSSSTKAPASGSSQSSAPKKMSSLSSLQAFHFKAPSSSSQSKADQDRILMPPPSKSRSTSPVKLSTKPVSSGSTSSQKSAPAPKTGSKPSSSSSRKGKGKENDVIELLSSDEEIDEIRPASPVRIVGKRKRKEESGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEM0</accession>
    <name>A0A1E3JEM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032408.1">
        <property type="nucleotide sequence ID" value="XM_019175918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEM0"/>
    <dbReference type="GeneID" id="30193005"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="582"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN98546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="876" mass="99662" checksum="5BEEFDE4B15D64A4" modified="2017-01-18" version="1">METEPSRDRDYSFARLCDIKSPVTLKITSLEGKLPQSSHTEALNHAKVIRSRADTPIPDLYITCTLWTGESQHTLPFRTGWKDLSRGTKWNQTIILPVQYPSLLLESSVTFTIWDVQESGRCTAIGGTKMALFDHHRTLKRGQQRLYIHRGVEADARPNSTTPSEVLNREDDEMGRLESLIKEFDRGDINKVEWLDRLAFRKLEKAHLRETSKSKDMYLYVDLPKFDFPVVYSEQESLLSVPPAPVAHLSPTSVPPVLALPPNFLSSDRHLWRAYDPDAWRDNPVEIKHRKLLRSQRLGDAGKDLKPGPSDRDRLNDIFRLPPTASLSALDKDLLWKFRFSLFRSPRSLTKFLKCVTWSDPVETKQAVEKLLPLWGQDVGIDDALELLGPEFMHKKVRAFAVKRLERADDEELLLYLLQLVQALKFEHKYFTSSQRPHKSRAHQLKRQPSQDQAGDSGLSQFLIDRSVSNPILSTRFHWYLMIECDSRAPVGRMYAKVAYDFMKKLSQSPEGTAQREVLRRQGVMVQTLSTRAREVRLSKDPRQKKIEKLKAYLSDPKNGLSSLAEPLTLPLNARVSVTSVVAEKSSIFKSNLLPLLIWFETAEPKRTAEDDSEGVVNISPEYPVIFKNGDDLRQDQLVIQLFTLMDRLLRKENLDLRLSPYSVLATSTSEGLIQFVPSKSVASIMAEHGNLQNYLKLEHSDDAALGSYGIEAGVMDTFVRSCAGYSVLTYVLGVGDRHLDNLMLAPDGHFFHVDFGYILGRDPKPYPPPVKVCKEMVDAMGGTGSVHYSRFQSLCYTAFTGLRKNANLILNLVALMVDAGIQDIQLEPDKAVQEKFMLDLSEEDAIKQFEVLLNDTSYLTVVFDRIHDWAQYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEM1</accession>
    <name>A0A1E3JEM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032213.1">
        <property type="nucleotide sequence ID" value="XM_019175723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEM1"/>
    <dbReference type="GeneID" id="30192808"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18556" checksum="625316BD8A507BA8" modified="2017-01-18" version="1">MAKIVPPMNFGLVEDAGFYRSAQPSELNFSFLEKLNLRTIIWVGAEEPSDILQVARPSQGIKLYNLAPQTNHLPPLPPPPEPLIIQALSLLLRSSTFPTLLCCNMGRHRTGTVVGCFRKLQRWALSSILEEYRRYAGMKVRVLNEQFIELFDTDLVSITAEQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEN3</accession>
    <name>A0A1E3JEN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032417.1">
        <property type="nucleotide sequence ID" value="XM_019175314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEN3"/>
    <dbReference type="GeneID" id="30192395"/>
    <dbReference type="OrthoDB" id="10540814at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="163" mass="18143" checksum="448D5BB235E2A4EA" modified="2017-01-18" version="1">MVQFTGFSGASLDPIEGVEYVEVKVPPIKWRNDVTKRFLTLRERSDDLEKQRVRSISAKRRQTLRGKEKKKAAEAQTQAETAQSGMGDDEMASSSRQLPDYPGAELDETYVQQSLGSCGTQTTRGLSGKSPLMTFLTLTRRGYATAPSEIPRVPTNITVREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF91</accession>
    <name>A0A1E3JF91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032422.1">
        <property type="nucleotide sequence ID" value="XM_019175319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF91"/>
    <dbReference type="GeneID" id="30192400"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="877" mass="96669" checksum="D9617704BCBD962E" modified="2017-01-18" version="1">MSRRDVDEAALLKLYGIASVYPDQWESIDHEQEGPLAGAGGLGDDGRNAGEVNDPLGLRGKLSGTMDLDLKTRAATSLSSKSFDPKVFLSAHHPDASYQDLRRGISNLERAIESRSEAVRILVEDNFDRFVAVKASSEVVYRDMKEGFLADDTDHGTRELREIFKVAAHRADQVFLPVLENAVKASKLRSTLAVFEKSKFLFTLPGQLLTSIQANQYDQALRDYKKGLYLHESRSGGGGGVIPGVNASREQQKRVFEKVWGSVEGIMGEMRNKLNAQLKDVTRGVEEQERTIEILIELDQSDEAAWTYLEYQHAHILRSMKAIFNKHQEKARAAERACANQNVAPGAYLVLLRRQLATPEYQPDPLSPTPTDTAWLAIHHLSKDLSSHVSKSFSAFWRIGKSCIQGRYSKRESSGGSTIPPSNRPASVCRTMALEIMKLYVGLVSGFFRLSDGGVAESGFANASAARARAGDGLPPASPSTGWVPQGSTSVLVGYFTEKLVDEIADCAGELGAYDVGNNEVSLMKGLVDSMKWKMEEVLATSWAKDAKLLHGLEDWSSPSVSSNKGSIRYLAVVESYQLRMTTAAKRVAANTRNGGGRDEKEGLGGGFKRRIREVVVETECYCFDGILEAARDEWKNEVQGKRVGRGSRVEELDISLETRLLISLSKFHHLKQTSIPAISSKVSKLLDVDMAKEQSLLLQVVGGMDEQVLKKYIGERAEVQDKIVREAVLEGTDWVNVGKPTEIRPYMHKIILLLVDTHAQVSNIAPARLAQVLQALVENVTQVVLGCFQRIRQYGLGGMLTATVEIEYFHSAVSLYITPQANGTLTKIYDTIGSVYGRQQSPDDLNKELDGLRRLLAASRKAMGMETLCLRAVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHP8</accession>
    <name>A0A1E3JHP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032693.1">
        <property type="nucleotide sequence ID" value="XM_019175590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHP8"/>
    <dbReference type="GeneID" id="30192673"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="343" mass="37362" checksum="EED796271BE4622F" modified="2017-01-18" version="1">MAANKNNQIVLNERPQRGPVTDTTFRSNVVDVPEPKDGEVVVRIDYASVDPTMRGWVDDVRSYLPPVEIGAAMRAPGLGTVVASKSDAFKVGDLAVGLLGWQEYYVGSAEGLTKRVTPEGGKDIDHLGLFGMTGMTAYVGMFEIGKLQDGDHVLISGAAGAVGQTATQIALAHPNCKVSVIAGSKEKLDYLKKLGVHNALNYKDADFKEQFHKIGNVDVYFDNVGGSILDLTLRQLNPHARIIGCGAISAYNAEKPEPIYNYFCLITMKSTFRGFIVMEHANLFPEGIAYFADLVKKGKMEFNYHVVDGLDNAVTALREMFDGKNLGKTVVRVSKEAVRQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIF9</accession>
    <name>A0A1E3JIF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor CWC22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032820.1">
        <property type="nucleotide sequence ID" value="XM_019175088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIF9"/>
    <dbReference type="GeneID" id="30192162"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="453"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="825" mass="93693" checksum="248A84600E273CEC" modified="2017-01-18" version="1">MPRSPSPSRSPSPRRSYTRSPSPRPRSDTVDDAPISKRKRSPSPNPRDRPASPPTRRRRSQSPPRRPESQALDAPRVNDVDPARRRAREQALLEKEINRELAKPNDDGTVATRPNADDAAKAEFAKLLGSRSGGAYIPPARLRAMQAEAAKDKKSAEYQRMSWDALKKSINGLINKVNVANIKHVVPELFGENLIRGKGLFARSIMRAQASSLPFTPVFAALVAIINTKLPQVGELVLIRLISQFRRAYKRNDKLVCHATSTFIAHLCNQYVAHEIVALQILLLCLDRPTDDSIEIAVGFMREVGLFLSEVSPKANNTVFERFRAVLHEGEISKRCQYMIEVLFQVRKDKFMDNPSVPEGLDLVEEDEQITHKITLDDELKVLESLNLFKADPNFLQNEERYAEIKREILGDSDDEESGESGSDESGSEEDDEDDVAPEKQGIQDMTETNLINLRRTIYLTIMNSLNYEEAVHKLMKINIPEGREIELCNMIVECCSQERAYSNFYGLIGERFCKLNRVWTDSFQEAFEKYYDTIHRYETNKLRNIARFFGHLLASDAISWAVLQVVHMNEDETTSSSRIFVKIMLQEMVEELGVNKVAERFRIPDFRPAFAGMFPMDNPKNTRFSINYFTSIGMGKVTEDMREYLQNAPKLLAAQHAAMAAEESSSDSSSSSDSSDSDSDSDSDSSSSSEYSRRSRRRRYSSDSRSPPRRRRDHSRSPSYSRSPSPPRRRYDSRSPPPRSPRSPRSPPPRRSTGRGRSPSPSRSVSRSPSPAPRRRRRDSYTPSPSPPRRRDSPPPPRRFEDGSRSRGGRGGYGERERDSGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JII0</accession>
    <name>A0A1E3JII0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032883.1">
        <property type="nucleotide sequence ID" value="XM_019175151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JII0"/>
    <dbReference type="GeneID" id="30192230"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="315" mass="34700" checksum="6A7DDB3E6346E2E1" modified="2017-01-18" version="1">MPRPPETPEVRNSKTLAYILRHGAEKEGLYIRQDGYIKLVDVLARPKMKGVDKDMVIQLVRDNAKQRFELFWGYDPSPPRPKKKPTQGKTKKQLQRDREAQAQAQGGAGDVSGEDKGKQPDAAAVDNLQASLVSAAISSPPSEPAPPPDLPLVSLPLPTECSPQPPSDGPQGEYFIRASQGHSIQLESTAHLEEVKDDEDGRARVGELVHGTRWELWDVLKEQGLSKMTRQHIHFAPSLTGRITPRPTSTLYIYLDLTKLVQAGIPIYTSANGVVLTPGGEGGIVGKEFWAKAVRKVDGKRVIVWQDGKEVEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIN1</accession>
    <name>A0A1E3JIN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032951.1">
        <property type="nucleotide sequence ID" value="XM_019175219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIN1"/>
    <dbReference type="GeneID" id="30192299"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="833" mass="91482" checksum="2A614DE723C5CC2D" modified="2017-01-18" version="1">MNAPAPPPPPPARPKRTHARRSCATCRLRKSRCELPDLDVPAGPEPLPIDKACHRCKVLSIPCIVDDGNRKRKRKEASASTPDAFASDSASQAGPSTAKRRTAKPQTSTLSQSTVHQSDNSLDIVNSLSSVPGGPTPTSAEDLVENYERLKRELGARGLDGESGKAKSIKLHGRPLELACAMLRVAYGRNDKRGRRVRLEDDEVELEDLVDDDMRIRVRKGVAQLRTYHPHLDDLDSMMVEYRRNPEPTIALLIATVVYLASAVLPPDVTVHNLRNALDAYIYQRRDSLLLHHPHTFFALQALELFITHCPFGVLPLQPTNLQNLGVAKGLTAAARAISAQLFFEQLVQQLLNGPGIAHNFYCGDIWLWLSLIASEAAAMLEESNPHKPKQLAEARTITDSFLGMTDLGSCLWQDGIGKEDMSVLVGKLALCDKVARLEEVLDGMARIKGVLEHSTTDSNVDPVRGILTEFDEYTRRTDAIDQRHDSMMSMLREYSGNIEVGSMSYRAIRRRYEFSKIHVTGLRALIATHYLPGSLYAYPDLPAPSASHSAVSYAISRACNPPDIVRFISDTNHNGGATPAVQAVWEWGRKRGVNMERNLTACSELAVSINSELHGVASTCVVPLHETICIAVESAKVLMEMEAGTIHILRSNNQLYKAFRPRSWLDAMRDFAQALRAVSVIIHDDGLGGETVASGASNLIGSMVRTAEDWTKSLEQEAARPLEPMGFPTEMTLDSVHALARQRQGHGNGVSVPQQGYMDTSDRWMASSEQELSSTSRSQSAQGSRPTPPTVVGTPNVPNVQQVTPLDMLLSEMFGYSCNPPQPPSKVEMDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIT1</accession>
    <name>A0A1E3JIT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Angiogenic factor with G patch and FHA domains 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032972.1">
        <property type="nucleotide sequence ID" value="XM_019175240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIT1"/>
    <dbReference type="GeneID" id="30192320"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="411"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52230" checksum="95F50ADC5AEBBC83" modified="2017-01-18" version="1">MSSSDTWVYDAASGVYYHAPSNTYAVPDPTTGQWSYIPAPHFHHASSSTGRSNPAPAQTASSERNNAGGLRGKEEGEVEDDVGWGGLMEPEQLAEIQRTGELKKKGVAEKAAPAAAEQEMAPYGDTPSYDDPALYAYQPGADEILELPKERPDHLLRLVVQTTASPKVAVGQVAVIDTREGGVQLGRDRCERGAQARVRLRELEVSKTHAVVYWTEGSEDEHDQEGWRVVDLGSTHGTFICTPLRGKEMTVLYRLSEPKHSSKPVAISHLSTLTIGSTTFEVHIHSSWPCDTCKLCGTNELPLETGEVHVEGKSLKDKDAEEQTWDVAMSSREKWGHRDARRKVEMANLKENLMKRNGDGSGSGSPAAEPAREYIDRSAMRRQLRPKSPPRKASIPATSAAVVSAAPASVQSKFAQGILTKQGWQEGSGLGKDGTGRAVPLDTQVRTKKRGLGAEGSVDDGDGDWRTKAKMRRWGEVRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJF2</accession>
    <name>A0A1E3JJF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032958.1">
        <property type="nucleotide sequence ID" value="XM_019175226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJF2"/>
    <dbReference type="GeneID" id="30192306"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="618" mass="69710" checksum="2D45F980B2586667" modified="2017-01-18" version="1">MASDERSHSKWYLHHLDTHIQASLKATLGNYPNPSLQVPPSDIPPSNAVWTSPEKNAFFAALSRYSRYRPDLIASEVGKSEIEVVWYLEFLEKEKVNMVNKEKRESRMKELKGSSKWREGLAPAAREVSDKWVEKEEELASGLHEMLEEMAQEHELGLSRKRKREAKRSIIQAAVIPPDTKSGDKTKFIDDLPEMQKLNQQWDAEDWLAVMDPEKLFELDDCIQQVWLAESQEELVRNAEPDGAEDVPSPSAPSTVSKTAIKVASDLRTMSLISSIPPKKRTPEQQRLFTAARNRQRGREQYRTKKLLVEGMTEEDIRKAGGADAVFAQKEGQELPMDVGRGARQRPEIRGVHDHVNEAGLEIFAFTNMARFLNSHEVPSDTSNVSLPVLQDLREELVVHLKLLLYDVITVAEKERLQDQSLDDVRNEIASNHVQQALALRGDLPPSFIVDPALSKIQPVKTGPTTSTVIISTDSAPDTDVDMSGNDTEGTISEASEEFLEGYPENVVPPTGLSWSLLPHLRLISETRSNGHESSAATDSDDDEDESLYEEDAMLDQALEEVDLDHDKLYEKDLWGVNQEEEDKDDELDDHADVWAKDPIERSTHEQGKSRRQSSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKW7</accession>
    <name>A0A1E3JKW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore complex protein Nup205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032764.1">
        <property type="nucleotide sequence ID" value="XM_019175032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192104"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1946" mass="213333" checksum="1B01C6C671386B61" modified="2017-01-18" version="1">MSSLPLLDWDPTTFALLQQQLARVVSQPTTSALRKLWALLEDAEPWLLNLTRLPPKNDKDKEYIEKNALELPSGTAIRVTGDLLTTTNTISDALSLSQLYSSVLALQAESHRHQYPSRSTPEISIYLLHQWSLDLLVFLEQLFRVVISQSDELDTHFEPLKNFVENLLGSRTEQGTLIDNILSQLDVLHSKLSSLLSSQSPSGPAFELLQFRVQALRAEQNKLASILGVLAEGGRLGRGQVVRILKWLKKVDRADGVVGMVGASLMAAWKPLESMDASDGRYDVAEDWCHDIKFLKLASSLTLQEQWTIPRLREPIKLAWSLFYLSCLRHDPSVIQTGIDQHEIEGWLLDSVHNDALALLHAQVVSISGGEGAGEVDVLVQQGNASEVGNNDFLVEQVRGLVDILAGKKQYLRNLRNKEEDTGARRSQVAPPAAHYQNFLRLTRAVYKSLPPDSAVELWENSTFTSTVLDSRNGLPGTAFWEMLAAISTGPECSVLCYEKLKDTRLPWTSLFKFYQHYIEIMPHIYEPIKSTRAASLAPMVLEDVEVCTGWTKVLETVVRWSPAARAALLQSKPQPLGVLFEFLNCDNVPISLKATILQAITAFTKRTSDPSDDEIISQSLSSYEKITYLNPALDVRHLEPGRIPQPVGWLSRMEWAENEEGRYALSRAYVEYLTELVPSPGTVGKPAQAVPSGLRSKLVNTLRRGAYQVIDGVFLSLKTRRYARDSERWEVLDTLTAFLEKALLSFSMSELLSPSASASSAGRTIGPIAVELSEEPGFVILLRLLSDPAVFAVLASVLDSAAQEGLDGQGGKREEVVSRVLLRVLRVYHRVLEVQLVFAEVLLVVLADSARNPTYPFKRPFGLQPLDNHILSHLSNITTIALLVADDDPAISYIATKLVATLSASPVFNRTDIFQGEYAGAVNRLAGILDASDDSIRISQAFVRKLDVEGDAVEDQEIVEDEALHGDVKKVEEELGMVTRSVILDILVEGTAQDVSSPNIAHFLLGYDFRHRDFALQSGGSSCLHVILRQLLDGADLSGPSGDGIIDRHPLLGAKSAELIYQLFSHPMTGRATMGYAMSVTGYSARQLASIPRRCVEWAGEEGPSGRAVYWDGSVDTTSDVLVSVLEFQRWIVSSASLETFSYDGHGASAARIAEILFYGSAHDEDELDGEQPQTPPLLIDLLSSIDVRWEEPELENRQLEFFAGFGFDEFKRVGVEWWDLKGLEQGMKAWAKGLERQGAITPASAPAVQSEIIYVLQKLGSKKKETDVAIAKGNFALSWNELLKISLAMLFKHINPDEQQILLFSLLDQLLLRLSGVDELSPGVGDVVAESVLVAMTQLATVLGVFEGVNLPVELLGKILGRVVDGATRPGTTETARGNLYAAITQFLTLISPQNLSYSQSLAPSSFSVTDSTPSLLRTTLTVLAGKKERLIPMLCRDAMDDRDVWKTECYALLGGIVGLCQGERERFVLGPLMKGGYLPLVVRSVKEKEGALLECLGPEAENLHAYWVFESKLAFLLALASTRKGAEDLLDSGLFEILATCGFINVQIQASEEALDEVEAAEISARQHRVLGGVLGLVARVLASLHRGTRSGASQAIGFLNAHREAVLALIREPQQSLSTSSLEECRTVVSILALVVHKVSSDELHSLSSFGAFHMAVLATAAGMFDRTQWVEAVDEEPKLEGDILSLNQSLLSFLTSATSSLKSGSGNPVFITGVHRSHSSSVKYIASAPSVGTAVNLLGELVEKIQEVDGEWEVILERMEEGGDLDEADVEKLRNEYIADSPLSDDLIKSAFISKTQTLFDMIESLLLLIWRHLLFYANDARSVLAPSAPQVRPDNLSISLSGSAFGASRSQELEGNRQGAGIVRMLERVGGSLSSVLLRVGDLEINPELRRLATSSSSPSIQGDAFFDMLVRRLKELVGGLVGDAPAREEGEEEGDALMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL28</accession>
    <name>A0A1E3JL28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032824.1">
        <property type="nucleotide sequence ID" value="XM_019175092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL28"/>
    <dbReference type="GeneID" id="30192166"/>
    <dbReference type="OrthoDB" id="10297930at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="23497" checksum="E9B143367EF7F37A" modified="2017-01-18" version="1">MSDDGSEINDPRLIPTSSTPPPYSDRQPSKGAAAILQFWLDDHDDRSLLSTLTDPQFAAQFASEVEGVDDVEQVTSWAQEALSFLPREAQASMLFGLSGMSEEVEGLASGSRQEEFQQFVNSAMQDAQWKALADSMCVETLAEALRQLEVDHSAKARPQRKFTADTVTTSMSSVFDANGSEDTTMAYSPFTEDLEYDETDEQVRQGVEGKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL34</accession>
    <name>A0A1E3JL34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032834.1">
        <property type="nucleotide sequence ID" value="XM_019175102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL34"/>
    <dbReference type="GeneID" id="30192177"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="636" mass="68939" checksum="F4EDF067AC200C09" modified="2017-01-18" version="1">MADNFKAPANPNVPQDIAHIMELVATDQVVGAMPSVDMSAAEKRKLVEESIKRGKVVKPESDSDSDSSSEFESSSEEESDKEPLTAEKHQELKAELDEFVKDGEVEWDSDSDEGINLDKMGFDFMEDEDEPAGGPIASIHEAPLPPVKQPPLIKLPDGEGVSLAGDVVSWMREKKVEAWLEINKMEGEDVQAAVDAQVRIENPEAAPESIPAAASEDTPVTATESASEAPEAAPVIAETAPKPVKEVKQPNFSSSGTVVVRAMQSRPGDHDEGWLEEGSILCWEDGRVLGTVHETFGPLTSPFYTVRLPPPPFPYPSPESLVPGSRLFYPLNNSYRSFVNMIAVRDPRFKGTDASNLYDEEVGDDEVEWSDDEAEAAAKREKKNKKGKKGKKGGSIAGTPRALIAGLPARPHFDYQPDDASGAGSMYGGDDERWEMGSDAGSTVSRGRPAPMPYDLDEPNGSAERGGSRGRGRGQGRERGRGRGRGGYGGQSTAPLQQQQSPVDFQYQQQPFQPYPNQWQQPFMPGMPMPGFGFQPGFPQMMGFQQPPQTPQHGGYTPNQPSGVMPAFGQQQPQQQAQQQQQPQGVAINPRFAAQYQAMMGMGQSMQGGMGQGAEQGGQNGAYGQGQYGYGQYQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM16</accession>
    <name>A0A1E3JM16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033115.1">
        <property type="nucleotide sequence ID" value="XM_019174736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM16"/>
    <dbReference type="GeneID" id="30191804"/>
    <dbReference type="OrthoDB" id="2596482at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31242" checksum="0CC8F7DD26EA62E8" modified="2017-01-18" version="1">MASPTEETRKKRKTTGDTTSAGPSPTPSKSEPLLHHHSSADGDILLVSSNGTGFLIESYMLKAHSSVFRDMLSSNDLLPSHSSSPSERARLDLSGDTENAATVKTVLSILDDGLTLRALVDDLKSQSIPVLHNMLHFAQEWDMPFLSNHVQSILSKALQHPDDLIRQVAEERLSPGDIFILAARSEMPHLARLAVARMSYWFDESDRPEKGASPPIYTHWWHPGIKVGAASYPCIKPSAFAMIPNKYMWSLLESGHPTIDKSERGDEFLQSIDSHDYCFHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMH4</accession>
    <name>A0A1E3JMH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033310.1">
        <property type="nucleotide sequence ID" value="XM_019174931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMH4"/>
    <dbReference type="GeneID" id="30192002"/>
    <dbReference type="OrthoDB" id="10295970at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61708" checksum="CEB65804AFD5A81D" modified="2017-01-18" version="1">MLAVKSLLSPKRHPPSSYDGDLESNWENIEFYPEDHVYYNAYNDASRTLNHPNETLNIKQASRWGYCASRESTPRKRTKMSHVPYISPSHKKLSSTFVDDDDNHDSYESTSSLKSLLAQKQVTPNLDEKMDSLQPGFILPPPRKSSICHQMGAKKTLPEGLLVSIAITNTGIFNNQVIFRVLYTYCPLYESPPFRVSTYRTFYELYDYHLRLYRDQKGEVDEEARRRMLDFPRPIDGLDGWEKTDYRFKGLNLYFTNLLRVPVTIGTSHLLDHLVTRQFLAVRPGDRVEIVGKAQMGLDWESTLERKKMAKKGLENESRVDAVLREDSAITPAPQNASLAVKPSTPAERHSVQPILAFPIPFAPLSPRSSAPASLQSPMLEDIQGQDSAPHTPTHRSIVYSVTSLSPQTPTTPTAAQSVAIIETAIHNPNHDKELLPVSYTTQDDRRVDDGLGFAHILLVERNTWKTWQVLVDVDLPWETIFGRLYEVISAPLGSKMLKGLVHGGSKSGEIHAREILLSNGKVFAEWVKEAQKFLLLTIWVEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMJ2</accession>
    <name>A0A1E3JMJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033343.1">
        <property type="nucleotide sequence ID" value="XM_019174964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMJ2"/>
    <dbReference type="GeneID" id="30192035"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000101">
        <property type="entry name" value="Wos2 protein (P21), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="26242" checksum="CECDBA87D9649A8C" modified="2017-01-18" version="1">MAPLHPEITWAQRSSESEPEKNVIYFTINTPDIQGEPKFDIKPTEISFSAKAGDASKGIPEKEFAFDLQLWDEIIPEETKKLITSRAVVLTLRKKENKAEYWTRLTKEKPNRNWIKTDFSKWVDEDEQDEAEEPSGLEGSQGMGGPPGMGGPPGAGGMDFASMMQGMGGGGGGGMPDLASMMGGAGGAGGPGGMDFSKLMEQMGGAGGGAGAPDLNFGDDDDDIDDSEEPTDAKKGDASGVESLDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMS2</accession>
    <name>A0A1E3JMS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033208.1">
        <property type="nucleotide sequence ID" value="XM_019174829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMS2"/>
    <dbReference type="GeneID" id="30191900"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="43759" checksum="FB6C64BEFF0A9CD6" modified="2017-01-18" version="1">MSHRKYEEPRSGSLAYLPRKRAARHRGRCKAFPKDDPKKPVHLTATMGYKAGMTHIVRDLDRPGSKMHKREVVEAVSVIETPPLVVVGAVGYVETPRGLRSLTTVWAEHLSDELKRRFYKNWYRSKKKAFTRYASKYTENNGASVARELERIKKYCTVVRVLAHTQISKTGLQQKKAHLMEIQVNGGSVADKVDFAKSHFEKTVDVGSIFEQDECIDIIGVTKGHGYEGVTARWGVTKLPRKTHRGLRKVACIGAWHPAMVMFSVARAGQRGYFSRTSINHKIYRIANGAAGNSGSTDFDLTKKDITPMGGFVRYGVVKNDFVMVKGSVVGPVKRIVTLRKALRTHTSRAHTEKVSLKFIDTSSNFGHGRFQDAAEKNAFLGQLKIKSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPA6</accession>
    <name>A0A1E3JPA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Prolactin regulatory element-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033219.1">
        <property type="nucleotide sequence ID" value="XM_019174840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPA6"/>
    <dbReference type="GeneID" id="30191911"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO01967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="405" mass="43157" checksum="015BD71FF86B928B" modified="2017-01-18" version="1">MTRTAHHAHPTPSYPVYCLDWATDDSLLLGGGGGATRSGIHNKLKLCNVSKDGKKLKYLNELSLSNDEDAPMTMAVDRASKQLVTGINASQESIQSGVNDHVRVYSYGDEKIELVKGQKTIDAAWSDDFPYQKLSVISPSGKLLAVGSTDNKVVILQFPTLEPVTALSTDAELTDLDWGGPDGNWLAVTTLSALALYHLSPSLALTLQQTIFPPTLDIVPVAFRSARFSRSFSTPLHLHSVLNASKAAKRGGPRKAFVCTFGVVAEASKAPLTEEEKATAEKSGAGEEEDVGKWDVLAKREVAGKPVTAFDVSSDGKILSYGCSDLSIGILDARTLAPLLKILHAHSFPPTALKFNPSASLLVSASADNTVRVVVVPADFGGLSAPMIFLILTILILILALALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR47</accession>
    <name>A0A1E3JR47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033402.1">
        <property type="nucleotide sequence ID" value="XM_019174350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR47"/>
    <dbReference type="GeneID" id="30191410"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="352" mass="38808" checksum="C9C88AB99CCEF748" modified="2017-01-18" version="1">MSSNLVPVVIPYPDLAHPHDPSLRERLRQALGSHRGALGIVVISELPGDFPALREKLFRLAQELATLPVHEKQKLERPDTSYMFGWSHGKEVMNGRPDTQKGSYYANPLLDQPDVSERLRQDHPEYYAGNVWPNGIQRLEEFEKTFKSLGRIIFEAGLLLAKACDKFVVEPSDRHGTISSLIQHSKSNKARLLHYYPQDQEAGSSDCESTLGNDALCGTHLDHSLLTGLCSAMYLDAADPSKVVPSPSDTTGLWIYPRESDTAVKVSIPEQCLAFQTGEALSLLTSQRLAATPHFVSGSTASTTPVSRETFAFFLQPDVDDVIGEDGETFGAFTKRVLGRHYQGDVAAEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRB9</accession>
    <name>A0A1E3JRB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033461.1">
        <property type="nucleotide sequence ID" value="XM_019174409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRB9"/>
    <dbReference type="GeneID" id="30191470"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000325">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="320"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO03410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="692" mass="76458" checksum="4E937507CAD4A4BD" modified="2017-01-18" version="1">MGRRAKNKQSDPRPLPGSVPERDPSRRQKAKKRAPSSVAAGDARQAKAHRGPATKKGVKVGKTGNVIQGRRGKKVDEVDEDSDLDEALQTGEFSSDEEEEEEIPKAKKSQKSKTEESDDEVVQRGPAKELVFSDDEEEISDDENLNDDKEELPKGLHAFDLDAAPSDEDDEEMGDEFEMDEDDLSEGDEDEADSAFASSGDEDADMDEEEGVFGSEEGDDIQTNLEDDLEETFTLPAVDNGGEEEAIEHGVSLRDVETRMRWLVGVVINKDEKVSMGVPGKSRSDHLLQLQHDIATYFGYNTFLVGKLMKLFPADEALAFFESNESPRPVTIRANTLRTRRRDLAQALINRGVTLEPIGKWSKVGLQVFESPVPVGATPEYLAGHYMLQAASSFLPVIALAPQPNERVLDMASAPGGKTTYISALLQNTGTVFANDSNKARTKSLTANVHRMGCKNVIVCNYDAREFPKVIGGFDRVLLDAPCSGTGVISKDASVKVNKTERDFQLLAHLQKQLILCAIDSVNPNSSTGGYVVYSTCSVTVDEDESVVDYALRKRPNVRLVETGLEFGVPGFKSFEGKNFHPSVELTRRFYPHKHNMDGFYVAKFKVEPRKKLTKSKKDKEEEEEGPQMTITEEGEIVPEEPANFDSPEDAKLIQESKRKALKKKGIKVTPKSEDKPKKSLESKGKGRKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRF7</accession>
    <name>A0A1E3JRF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_02297</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033501.1">
        <property type="nucleotide sequence ID" value="XM_019174449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRF7"/>
    <dbReference type="GeneID" id="30191510"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="204"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODO03450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="570" mass="62951" checksum="287A58EF4F08E882" modified="2017-01-18" version="1">MAPLISFSALLRATRPRAGIFSRRGVSTFRQHPAIRTLSPGLVVGAGVALIVPTYIYYNTALLESHTHVVDAAVPDKPHGLEAEQGKVKKISIKDVLEHKEGERIWVVIRGEVYDMTEFLEDHPGGDEIITSNRSRDVTPLFNPRHPTNQLEPENLPPTVQHLGTLDTASASDEEKEELRLKVSKDEEDEKERIKRLREEIEENGLGKIVNMRDFEKLAEQMVSKVGWAYYSSGSEDELTMRNNNNVYKNICFRPRVLRNIAECDASTTILGYDSTLPIMISPAAMAKLGHPLGEVNLTRGAGNTGLIQCISSFASCSIEEVTDARKQGQPLFFQLYVNAKRDLAEAVIEKVNRLGLNAILLTVDAPVGGKRERDIRLKGAFEPPKTGAYEEHKDTKGVSEAMFAGVDPRLNWDDIKWIRSQTKLPLLIKGIQTVEDAVLAYNHGCDGVVLSNHGGRQLDTTSTGLETLLEIRKYAPQLLRPQFRGPTERKFEIWVDGGIWRGSDAVKALCLGANAVGSGRGFLYANAVGGQQGVEHAVNIFSAEILLTMRLLGATKVSDLVPSMVNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRK5</accession>
    <name>A0A1E3JRK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033545.1">
        <property type="nucleotide sequence ID" value="XM_019174493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRK5"/>
    <dbReference type="GeneID" id="30191554"/>
    <dbReference type="OrthoDB" id="2576490at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="15461" checksum="26121887719FE2F6" modified="2017-01-18" version="1">MSQLSDLELVAQAMSGSEQPPASNGTAQATNGAQAGIELSSLPNVDPSSLLPADLASLHPLLASLSLSPEDLDNLDEGEIGAILGQLEAADGVADDLEGKLDRLLEMLGGVEEEIVEGKAELQEGESLPKTEGEEKGAATETKIEGKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRP6</accession>
    <name>A0A1E3JRP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IQ domain-containing GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033397.1">
        <property type="nucleotide sequence ID" value="XM_019174345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191404"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="648"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO03346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2023" mass="224686" checksum="8B0ACD4F04B56070" modified="2017-01-18" version="1">MPADQPDNQQTTPPRGASGLGRSPSIFSYQTRLLGQTANGRQTPPPATSIANSPAYTSLASIAGRDKASPPSTPIRRAVAKMVIDSDSTPPAKTPRPSVGHARSAKSVDLVRGQWEAKIAGVPEPSRPPSRSSRLGGTLVPAAPAPVLTTTESPVDEKSTMPPPPVPNVEGGSSRFGSTYMARRAAKRATVDGVSAFDPTRIPSAASTASASTSDRPASPSITSSTSLLTPNATGDSLAPSAKGQSVEERLAIAKANALKRRQAREQAKAGSAQSVASLDVAQPAAKTPETKQSETIASGADVQSVTETRPKDLGDGHETSRLSKATETDAKKEERDVKQAAKPSPSTPLASKIASSPFAQLFTPPSRPATQSETPTSSTSSNPQSSLRSIATAPSTNRYVPSGLSVASAPPSSFEQPKNSGGKYGSISKSDNRRLGRHLPRIASGEKGWEDDQASKHAKGPSEGRRVPSTLGRKSVTADSEEENKPPVTKADKKPEASSVAPSPKTSISRATRPPDIDILGSSEVENRSSETRPTATPTKRRSQFMPYTPKSTIPDFSGPKSPRVELSGADMKGLMSAVGSLPARGDAKDEEDGVTGMSNRLRLTKSRLPPSASSASVAPAPLPSKRLMQTNWMDRNRFALGSYEYLCHVGEAQQWIEGCLDEELQFGVTELEDGLRDGVVLAKLARVYEGEGVVKKIWMESKHRYKQSDNINYFLNFVRNVGMPETFIFELTDLYDKKNIPKVIFCIHILSHLLARLGRAERIGDLVGQFEFTNEQIEATQKGLKGVAMPNFGDVRNTLAKEASWVPEEPEETEEEIRDRLLLECEDSIVSLQSYLRGHLARKRASRVQAQLELADPITRRLQARARGTLCRRALLAQLDERKPLQEMTGSIQAAARGKMVKKKWQARLGEVRSVERNILAVQAQLRGVLVRSRKRGEAKRLRQTGRAVVGLQAHCRGCMTRWDRKLHQATVALPHVVESIESLQALLRGRLHRQNAARQQRVIYSQVPTFTSLQSQLRGALVRRKIRAQEQKMDDASTYVVAIQAVSRGVLARWKKRAFTQVLQQSAPSTISFQTMARARLAKQTHKSMQKALAKVEVAGSVGGLQAFLRTRLAKKQTTEQKKKLEFVQPDVIGFQAIARGYLAREDYQFWREYLHDGRTIGALIFLQSLIRGFNARRRLYIRTSYVHQNVDKIVKVQALWRGRQQRLSYERMITGVDVDVPTIQSYMHLLDDTESDFADQVRIEALRGQVVDLIRENQNLETEVKDLDTKIALIINNQMTFQELARAKRRTEQATYHAPNNDPFSGGVHLDRTNQRKLELYEQLFFMLQTKPEYISRLLRVLAKGDGSSEKEMRLLEGVTMILFAFGHERREEYLFHKLLQLAVHEEILRAHTLHDLVNSRFPILPITTQYTKTSLTPFIHDVVAPHIMRIVSAPELDLCSDPVKIYMDIINAEETQNGVPSALPRDRNADQILQEHAMTRALFIRNLQELRNLTDLLLGDILQAHAKLPYTIRLLAREALLALQTKFPDASDDDLVPVVAKTVILPFLLPAIIAPEQFGMAPEGVGAVERRNLSELANLLTHVAGQQYTNTPDQRLLRTPLEAFITAMAMPFREWVLDVADVEHAEGHFHAHELFESTVEAKPIKITRSDIYGTLSILVHNQDYITLGNKKDPIISILEELEGPPIEYDRGKNTVNLRLTNRLAGPQPGDPDAAAKADWIQAKRHVLAVLRVQSGKTLFDVLVSSPEEVHEQMWIKEVHRDIALETARKAKHGLPPTPVEAEYQIESIRSMPFHEVKSRAIEFCMKLERSGRLSREDNLQGLLVSIASDIRQKHHLRRIRKDNLAGMVKAHEDMSKKKAEFESQVKAYHDYIDGAMAELQAKGKKKPTFMSKQYRHQMSQRRQGKQAKFGSYKYTASDLYEKRILLSVNQISPRQFDKLFIVISSNEVGVFDCQLLYPSSPTAPGGLLGEDQIRMEDLLGAQYENKERLDMFDGQAAFSLNMLIHQVNKSELCVSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW28</accession>
    <name>A0A1E3JW28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033716.1">
        <property type="nucleotide sequence ID" value="XM_019173909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW28"/>
    <dbReference type="GeneID" id="30190961"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="18097" checksum="7E82E301EC5F8976" modified="2017-01-18" version="1">MLPETKGTDELPAAHPTSSMAQQRKTVGNSSQAACKQYAAQMKKDVLGADEEQKAMRKKEGVMRIQALPAAVVHRSSKSTAKAFQAKLWELPDKMTLYPSDQNLEQVLDEALSQVKSSWSALDGALLMKRTGSRPDLQNTNSTGPNKCTENWQLFFCQVQLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWK1</accession>
    <name>A0A1E3JWK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033894.1">
        <property type="nucleotide sequence ID" value="XM_019174087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWK1"/>
    <dbReference type="GeneID" id="30191142"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="312"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="648"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="800"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1175" mass="125797" checksum="A4DAAECFDB79B559" modified="2017-01-18" version="1">MWWPFQWLIVYLCGGLTFLPLALTVVLVYVYQYGTTPIGDKDPYKFQKATLQHDAERAEQLQKQRYRAPSSTSPTVSGWITVRNTFNPDGWTIGNGKPGGESQVTGTSTPVTESPSEELAEEESWGKANTPSSGEQTPGSADAQGGKMPYVPYTTRIAQTYRTILPRQTKAPIPRQYFFGVLKSSVLYLYEDEAQINCLHAIAIDDYSVGIEMPSGMFEGKDGEMFAKRHGIVLKIRKPGKGMPLLSKSMEATQTEFGLANSPIYLFSKSNTKMEDWYIALLHVSTDHLTWDQVFAVDDMKNLVDTIDTEPDPIPMRWFNAMLGRVFFGYYKTETFEQFIITKIMKKISKVTRPGYLGPIVVREVNVGTSPPLFSKPMLKNLEKDGSTAFEVHVQHRSRASQPGSDIRLTIATTVTIPTGFKPYVVEIVLAVVLKSIEGNMRVEIKGPPSNRIWYGFTEMPKMEMEIIPIVSERKIQLGMVLNAIEKQLKDAIAESVVLPNMDDLAFFDTSSLPIRGGIFDLAAKVERNATGEKVEPPVEAPVVSKEDPDSAVPTTTSIRQRQKKKSQLAEGETVFPAPASQSSTDSGPPIPRTDTAPPAIATANSSAVKKAAALAATKKWFAQTGPKSPSLAAQAMVGSQGAAAAASSSSAPALGIPKDSSEKTGNWENQPEVAPVEVSSSTTPSAESIRGHNNNGSITSMPGQTVPSGPSSVKGFDTSSTLSGSSTETANPTAPQASTASLISSFRSRDKKAIQAQVGSARDQVKKWGVSFAARRKATREGGDLGAGDEVVDMDEAGLRALYRPREEEEDARDDEPLPVQPLSVGSQRSLQARLNAAAHDTGASPLPRSRSPSGQGVSIPGRNRSHSSSKHSLFSASPRAASPRASASTSPSQWIPTAGMPTTGIAKDDHAVGSPGSSISASGTQGHSRRHSNATAISLQPTSGRSMVVPRVPKRPGQVMGFGSDMSSQSGEIGSSLKKADEDKGAEHAEPEVLTVGQPPELPPRKSTDGVSDKANDTLVSRSVPPPRPSSLTSLPPPLPGRKPSPADSDRSRDVTHSGISSTPGALSPPRTSPNRPNPVPDKGSLIDGKSSDPSPPSDDTLISSVRRSESRRLPSESTSASPAYGAQESLRLVAQRHEEAKKANLLEIPEKDEAAKKEDGEGASHSGGDMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWQ8</accession>
    <name>A0A1E3JWQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01993</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033956.1">
        <property type="nucleotide sequence ID" value="XM_019174149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191206"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1314"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1338"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1378"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1425"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1451"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1492"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="373"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="621"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="252"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO05301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1546" mass="170947" checksum="37B80C1411704AD2" modified="2017-01-18" version="1">MADPPGPSNRLPSAISASRPTPPDTHHPVIVSPENRNIVQLSPSKTSDHEDEVHDYTEDAPQAMVDAVAMEIAKHEQEGPPEMMAGSMASWAGVDDGDGGIFPSSITRTHMRTGSRRASIASRHSVSSFARPSGTYRRQGSSQIDLIRSSGSQVFALDNDENEGAGEEEHAAHRYIPSHRESRRGRAGSEAQPGSYFSYRAYEREPNDDYSTSPEAERFSPTSASPTQPSTALGRIASFMGFARPEADDEEALYGDGHSYRPSHPRSRSRRGSTESRAYSYQQSMSPTGSDDEWGYGDQDMDYDEEDDYHSSLADDTSLPPQSRPGSPSIPLVPSATDGIFGEPHAGPYEDQEPRDFVSVAVPSRQTVVLPDEDLSIRFTCYRTDRLWNVIWLIGCVLSLGALGLFGRWVPKIWVQFVGKEVAFDEAPEGSWLVVETPYGDLHIISLDIIAYPYPLSTVFPQSIPPVMVSPSSTSHSPSSSIWEETTGLLKVMEYRYTKFALDPTTGRWTMIRDWRDPRWTSSRAVAQGLTSLVKEQRLALMGENMIDIASKSVVGLLVDEVLHPFYVFQIASIILWSLDDYYYYAFAIALISVTSIMSTLMETKRTIERMREMSRFHCDVKVLVDGEWQIVDCAQLVPGDIFDSSDPNLGVFPCDALLLSGDAIVNESMLTGESVPVSKIPAKDETLRALSRETKHGSSEIDADLAKHYLFSGTKIIRVRAGAKPAWAPASEAPVALAMVTRTGFNTTKGALVRSMLFPKPMGFKFYRDSMNFIGVLTIIAGLGFAVSAVQFVRIGIAWHTIMLRALDLITIVVPPALPATLTIGTTFAIDRLRKSGIFCISPNRVNIGGKVNVVCFDKTGTLTEDGLDVLGARTIDKPDRRFSELHSDITDLPIEGGIHGNTPLLYALATCHALKLIDGEIMGDPLDIKMFEYTGWTLDEGQSRPVTKGSAGGVRPQALVQTVVRPPGTDKWRMEDALKQGSKHAHFLEIGVIRTLDFVSALRRMSVIVKRLRSTSMEIYVKGAPEVMPDICDPASFPIDYEDMLSYYTRNGYRVIAIAGKSIEGMTWLKAQRMRREAAESDLQFLGFIVFENKLKAGTTPNIHTLRAAHLACRMVTGDNVRTAISVARECGLVSHSASVYIPTFVPGTGNAEDARIDWTSVDDDKLQLDEWSLKPLTNQVGVAMDTAEAEMHDYQLAVTGDVFKWMLEYAEFETMERMLVKGVIFARMSPDEKAELVERLQALGYTVAFCGDGANDCGALKAADVGVSLSEAEASVAAPFTSRIPDISCMVEIIKEGRAALVTSFSCFKYMALYSMIQFATVTLLYSFASSLGDFQFLYIDLFIIIPVAVAMGRTLPFPKIHPKRPTASLVSRKVLISIIGQIVINAAVQVVVFVWVRRQPWYTKPDTNVDKLETINYENSALFLVSCFQYILVAGVFSVGPPYRKPLWTNPSLVSCLVALGAFSTYIVLSPAKSIAVILDLMSLKFGFKLQLLGIAGINIIASFAFERFGERPISRLIVGVKRWMWRRGRRREYRPIEREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWX2</accession>
    <name>A0A1E3JWX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033901.1">
        <property type="nucleotide sequence ID" value="XM_019174094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWX2"/>
    <dbReference type="GeneID" id="30191150"/>
    <dbReference type="OrthoDB" id="10315236at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="627" mass="68903" checksum="972405AD3BBB192D" modified="2017-01-18" version="1">MSDQTPRRRYYLTIAYLHPPHEGQLVNFHLDLTDRGGLVSTTSSNLKHEHELKQRLSGNKRLWMRICQGRFQGDFEDFEHLMGYIFRDATANRYYTSYYHEDDTMDILLGTIEEIDHQCAAIQDSRPIVNGPERLPSSPARSNKTIPETALERSNSNISIRAVVGHPQPSRAPDLKASQSQVEESSQLKYYRRQALDLQQQLEAQEALVDDVITSASHQKYLFRIHVAGVHDRQSSLKVLGGLPDELKVRMWATKSWGSDMLDQTKWALRVLGGMDYEDWKAIEVASDKRTVSNRREDVPEIYLIFSSRTINSSELRPQQPQITVSQEPALSIVVAQTNAPPEPATLARAPTQAIPYLRVSDMPTIPNLPPSSALSSPPSYRSGLSTPSSQPSMASSFQSTVDGQRLSPPHPERYRIASPSPTPSMYRAAVAAARFNLPVSNSSSLSGLTLEPRGRQQAPTSSPARSVPFSPPGGLSNSVSSLASDIILTPHTSPSNSVPPTPYPAPSLTQVYQGSNEGLWNRLDKLGPMMDDAKQVAAWINTNEAIVNHPFAGNIPPESSGVTPPASPPATQKLRGPRVFAKAKPLPTAIGTKGVVSGQAVIEDDSRLVHRPPQGYPSSSSRSIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWZ2</accession>
    <name>A0A1E3JWZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033968.1">
        <property type="nucleotide sequence ID" value="XM_019174161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWZ2"/>
    <dbReference type="GeneID" id="30191218"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="46"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="61170" checksum="46B867B23500CCD0" modified="2017-01-18" version="1">MSLEDKEHKSFDASEPAEEAYVAEVVSEHIATDLTNDPHRGLRMRHVQLIAISGSVGSALFVSIGNPLTSAGPLGLLIGVALWSLVVWAASNCLIEMTTLLPLDGGFVKLSGRFVDWALGMAVGWNYVITQWALICFELTSINVIVQYWKDDLNPAILISACLVLLFLINVWSVRWFGEIEFYISIAKLILIVGLTLYTFITMVGGNPLKDVYGFRFWKTPGPFAGEVNFRKVITGIFDSISWATFAVVGPDYISLVGGEVKNPRRILPKAFNSTVYRILGFYITGCLCVGIVSSSTDQSLLGAISGGAPGAAKSPYVISMNRLGIPVLPSIVNALVLISLFSTANSFTFVASRSVFSLAQQGQAPKVFLRTNRHGVPYVAVTATLLIGCLAYLSVSSGTARVLNWWIDLVTAAQLVSWTVIAITYLRFRSGLKAQNLLNNDFLPIRGYLQPLSGWYLLVWSPIVLLFSGYYCFLPGAFTAADFVFAYGSVFIFLAILIGAKIYAYFVRKDRQLVIPADQIDFKSDLDHIEELTRASEEKRLAKSRGAGEKVSDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYY1</accession>
    <name>A0A1E3JYY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034119.1">
        <property type="nucleotide sequence ID" value="XM_019173414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYY1"/>
    <dbReference type="GeneID" id="30190459"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="688" mass="75907" checksum="E28083C99E3C84E4" modified="2017-01-18" version="1">MGRRAQDARCSVCFASIFGDLDDVNEPRAAVATECGHVIHEHCMLRWIEMSADAQLANKQIDHRDEAEATCPQCRSEIYADEETGKPLIHRLYPVFDDEQGSSQVRSSPVKAEPVDEGLMGMARRAKAMKSEIDELGPESTRSQLERGAERVEGLKKDLEVSAKSISAVRTHVGGLIASINNLRSTITDYPLTPQLRDENMALRAQLESAHLTMRRIQTEMNQKLMAEVRIARREEQEKAVRLVEEQMERVDQVKSELGRAMAEKNASGKLAMERTNEMRKKVERLEAQMKRNIKDKEDAEESEGDKRKQLKRWMDKYEKLEKKSNEYKRENTTLAEEITALKANIALRPDPATHDLSWAEGDSSVTWVPPPDTASSNIRPAPPPRRVSSNHRTADESSLMIDMPSFHDSFSREVQSVPPQRSATAKTFSSDMFAGKKEKKSKYFGAGENGDDISDLSLKRKRNNSFSLSGLPEASLAPSSPSFRVPETVPSSSPPLPRASSSSNPFVRSKDSRATPATRPAQASLPSQSRPPPNSTVLVPPSSPPVREIVSPWDGVDESPSPPKKVDNGKGKGKGRTYLSDEYEDTASSKSTLPSRAEHRPASQTTARLPLSSRSLQPSTDSIPSSNPYTLSGKEKVRGSTTTTTTTGKDKAVNKTSAQQSILSMFADKSGRPKAGVVTGSKSKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ56</accession>
    <name>A0A1E3JZ56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine-tRNA ligase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034294.1">
        <property type="nucleotide sequence ID" value="XM_019173589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ56"/>
    <dbReference type="GeneID" id="30190639"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="215"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="41612" checksum="4964F0940096C1D2" modified="2017-01-18" version="1">MSAQAQEFIAAAVQADPQLVGQNDKDKAAIEKLTGETESLVKDLPALNEKLTPLTYLHANYPSTADVGLYTQLHPSLISAPATQHPTLPALLRYFLHIQSLPSVSSARSSLPNAYPTLDIDISTLTVPERKAPAPKVKKEKKAAAPTTVEGAAAAVTGAAGAVAAAAASTVEAVKDAVVGKPEDAAAQGKKQKKEKKEKKEKPAKAAPEPPTGPLPSMIDMRVGKVLDVKRHPDADSLYVETIDVGEEEPRTVCSGLVKYMKEEDILGQHVVVICNLKPVTMRGVKSFAMLLCASSKEGKEEGGVQFVFPPEGSKAGDKIYFEGEKYENVAPEGQLNPKKKVFETIQPNFTTLENREAAWIDPETKSVHRMRTANGVLKAQSFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ76</accession>
    <name>A0A1E3JZ76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01446</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034314.1">
        <property type="nucleotide sequence ID" value="XM_019173609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ76"/>
    <dbReference type="GeneID" id="30190659"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130663" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO06214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="304" mass="28589" checksum="734CD616962CF633" modified="2017-01-18" version="1">MKFATLLSATSLLTLASSTPLALYRRDNATIPSCAEDCFNTVDTVGSSCDDGDVACYCTDEQVVGYLRSCLSASCSTSNVTNAVIAGEEICSAHGVDVSMSDDGTISATTTNSAIAQATNSSSASGASSTSEWSSASESSALSAALSSSTTALESSAAGSASSSVSATASGTSATISASSEASSSETDSSSALSTASQSSASAASSGASSSSAASASGTSPTTISRASSASAVSSAAGSSGTAMSSASGFSSAVSSSTGSSTAGSGLAAANSSSSSSSSSSSAGRLVAGPAVLVAGIFGALMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ86</accession>
    <name>A0A1E3JZ86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SLY1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034183.1">
        <property type="nucleotide sequence ID" value="XM_019173478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ86"/>
    <dbReference type="GeneID" id="30190526"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="76278" checksum="983D04BFBF8699FF" modified="2017-01-18" version="1">MSRPSLLASQTQTLLTLLNLNTAPAATTAAAGPFPRPASPGTTFNDSAQAPLVWKVLILDEASKDILATSLRVQDLREQGVTLHMQLHTPRPPLADVPAVYFVSPTLSSIRRIAEDLNPPLYSSYYLAFTSSLPRALMEELASLILTNDPSGSTGQLISSVTDQFLDFIVPSPNLFSLLPRREVKPDVNAGKGKKPVKEEYVEGKPTYVVLNDPKATEVTIEEEVERIAKGLFSVITTMNMTPIIRCPRGNAAEMVARRLDAKLRDHLASTSSRGAQVYGVGDLQRPLLAILDRNMDLIPMLSHSWTYQALVHDVLDMKLNRVTVEAPENGRLQKKSYDIDSKDFFWAKNANNPFPSVAEDIDADLSKYKSDAAEITRSTGISDVNDVGQIDFTSNTANLKTAITALPELTARKTTLDTHMNIATALLQAIKERGLDNLFQVEENAVKQNKASIVNVLNGQTDEPGQTANPTPEDQLRLVIIYFLSTQDGAVSKDDLKQLEELLKDHGADTRALEYVKKVREFVRMSTMAAQPVVAAPPVASGGEWTRGFSVLGNRITDRLREGGIPAVGLDNLISGVKSFLPAKKDLTLTRLVEALMDPASASTQALQDTDDYLYFDPRTSRNRPGQGGQNKGRSQYGEAVVFVVGGGGYVEYGNLVEWAARTGQGQGGQQTGQGKKVTYGATEIVSPKAFVDALGELGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZA8</accession>
    <name>A0A1E3JZA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034290.1">
        <property type="nucleotide sequence ID" value="XM_019173585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZA8"/>
    <dbReference type="GeneID" id="30190635"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="420" mass="44654" checksum="094DADACC341DB18" modified="2017-01-18" version="1">MSAQRPLHYDASQPLYGISFSNSTSHPFRTALSTITTGLSNKLCIVDLTSSPNTSQSQSPYYSQHNGTSNNGATPEFNQMTQTSLNVPATKVAWEPRESLRLDEGGRGELVASSGDVLHIWEVAEEQERGGGGYVGNAYGGGSSWSMKNRSVLSNAKGAHGSSPPITSFSWNRKSPNKLVSCSIDTTATLWDINTSQAMTQLIAHDRAVYDLSWLPDSSDIFVSVGADGSLRAFDLRQLEHSTILYESANDAPLARIAFSQKEQHMLACFGLDDSKVLILDMRSPGKPVAELVGHQAPLGALAWGATGPSSRSDTTGGGWLASCGDDSQMLLYDLTAPISSSRPASQSNFKPPPANPSPYSALSPSATPASQRTPSPADAVEILPSKGWTARGEVNNLAFTNSGDWLGCVSGNRMSVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF2</accession>
    <name>A0A1E3JZF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034255.1">
        <property type="nucleotide sequence ID" value="XM_019173550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF2"/>
    <dbReference type="GeneID" id="30190600"/>
    <dbReference type="OrthoDB" id="2568964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="31110" checksum="2229DC9272B85C94" modified="2017-01-18" version="1">MTTPSKVAHTLTRVCLELRHKAGIEFVHLAAREYGKNVTRGFRREVSVLLLVPDPDTSEGGIGHICMAEILVHLDASTNELENVASRFWYDWEDWTVPQYLDYVKDLDAEPLKVRIPDKRANVPWSTVMDSLLEAVQKVTRCMVDRASFKALVKRISDELKVSDLQERVYEWQVEKVWSKGSHRKAFPVIRIAFKVMQGRSYREDPGAVMLMELEVESKKTCGCEESNDKPMRKVNNMSVSYDGEWPTFHHYRTDIPPPSLEDLVATEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZV5</accession>
    <name>A0A1E3JZV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034451.1">
        <property type="nucleotide sequence ID" value="XM_019173746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZV5"/>
    <dbReference type="GeneID" id="30190796"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="14606" checksum="484CCDCE1801CF78" modified="2017-01-18" version="1">MGGYAELSSPLDVREAVRMVKAHLGLKYVQLAEPAVVQPVTSLAVCAGSGGSVFKGIDAKLLITGEMSHHEVLAYVASGTSVILTNHTNTERGYLSAVLKPWLQDELDKEAASDEDASSGAKWEVLVSKADADPLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZW7</accession>
    <name>A0A1E3JZW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034413.1">
        <property type="nucleotide sequence ID" value="XM_019173708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZW7"/>
    <dbReference type="GeneID" id="30190758"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="527" mass="57895" checksum="FFFE3E7F8FD7BDE2" modified="2017-01-18" version="1">MAKYTLINAWGGTVISATTLVSATYLLILLWKQGTGKLRVRLLMGMIISDLALGLAILPPDIMLILNKKIATGTAGCNALGFVLTTILFTQHLWTLSIAVATFLLLRHPLSRITMAVERYSWLIAPGIWGVSILHAGVWYGKVGFANTGTLCYYGTKSHSPDLDRNLCQFFPRALVFILIIILYSRLFTFLRRPDTIQLSSATGSRLDPEAERASAGKKGSHILRPLARIKRLSSFGIESGSNHHAKEVNPAAPWEALEFIQVGNYNPLTMDAPPQAPLRSMSYNDGLSFVSHEHGRASRPASFLSSPASQLRDTFAGISSNPSSSRLGSLSSDISQSTAVTQGEPFTAELLYNGGRRKSSASSVKFPAQPNLKGNALSPIISLGRYESNIVEESVDSEGKISKEEEVEIVEKEQTMEEFFAETQAPRLDEGRPGSFSGAGGQRSAASYFNRQASLLMLYFPIAYMFVFSASLYRLIYNMVKGEASPVLSIISNWMVFSVGLIDALVYGVAEFMIRRRVRRKMPDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1K2</accession>
    <name>A0A1E3K1K2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034172.1">
        <property type="nucleotide sequence ID" value="XM_019173467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1K2"/>
    <dbReference type="GeneID" id="30190514"/>
    <dbReference type="OrthoDB" id="10344673at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="641" mass="69573" checksum="0AEBE0FCFA36EECF" modified="2017-01-18" version="1">MAISPAPNNTLQASPPPGNVVQQPPLPSLQACYLGAVDSYRPSLPVTDLLDVDTRLEASLSITTGHNNTVTPTSAIPTSVIHSPNQASPMLYIPDRLSTPSASAKKPSIHRLGAAKQPGHRPIPYNVNESPKKKKSVALQKSTVAMDTGSKEDDGMEVDPPCASDGIEMSNGGGGGGGGGANKTPLRHAKSMVNMPVRPPSTRKSPPDPNGDTRPPPPLTSHQYDPFFAQINESDVGRSPTQLLMDYQTVEYVNETVMKIPNIKVEAGKAASSSNGADNGGGITGLRTAASVPVFPRQTDDTPGQRLPGDNTSSGVLDPNAIHAQHSSLSSSPPPATQLNDSSSYPPALLPPLKISPFIQNVLHHLCGLHYNAMMAESLSTLHHHTAHARYDAVKFAGEETQIIEKHIDQRYREASAQVLSKGWSLKVAQSMGQMAAERMAKSIEWDEEQKQMKTKWERLQNGDLTDTTNARIHPRSLHNQLLGFTLTTLLVPQTTIDVNAGRYAHRGIVRFVGNSFGPIITNIQQMLEIQTLQDMSALRLLAYEVAWRVHRHEWLTSVTTVAEGKQVKLPETLFEDVGKGLMCKIMEAFNGRRDGVYQDTDGKGKVNENKRGLEEWVLKAVKVWKTTGEAMLGRYTAGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2E1</accession>
    <name>A0A1E3K2E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034656.1">
        <property type="nucleotide sequence ID" value="XM_019172930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2E1"/>
    <dbReference type="GeneID" id="30189971"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130736" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70921" checksum="78E6686153E5EAA7" modified="2017-01-18" version="1">MRWFCTALFALPLAAALSEYHYLSTVNQFATAFLSPNNIEVVRSINSTLFAEDVTGTADLSTNFDGRELSTEYLFGLFVNNAEESDDPSPFGIPISYNVTSLLVQHEFIAASIKFMFHYPVLNKTYPIQIDAFIRVNEKGEIQQYDASFRRWAWATDVIIPELLPHMAQRLSLPVTNTSLVLREYLSRKICNTAATYCTGDDQQYDDYDSCMDFLNTKKTGEWYRMGEDNLVCRHLHVPMLSLRPTTHCPHIGPSGGDIDYEQVVLASHFPAGFLAPKQVTPENEKEVGHIQAASGYPLDPLLEIALSTGDMHSWDPTLYATALLGYFLIYYIFSHGLWQYFMRFTTKFRGLELEHQKNVVMYAMNIIFTTVALALQLAASPALGKHYRLWEVQCLRTGGVLVSALYIFELVYRLKMRLPLIAHHFLTIIAISFTVSVFEYTMSMSYMVSAIIWLFQATTEQPTFLGLMGYRLGWSRTLVARLLKFAAVQTFILKSASAIGLIVYWALHQNYDYRPIDVAWTCIVFIVAVGLLLTQAWGSYVTYAIGARIQQRHSILPTLLPDAASHYPKDGSADHRPILNSALSSHTLIGDAEPVSPSSSFGGKAKMLWNKTASLSSSEGSEGSASTGAAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3F6</accession>
    <name>A0A1E3K3F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035107.1">
        <property type="nucleotide sequence ID" value="XM_019173381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3F6"/>
    <dbReference type="GeneID" id="30190424"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="528" mass="58521" checksum="FEBF639A3620EA6B" modified="2017-01-18" version="1">MHATRYKHPPAQRQVMRVLLMPAVYSIVSFFSYRYYTEYEYYILAETAYEAVTLSAFLMLLMELVSMGTVDMHIGSVLAEKDKNKFPFPFGFWRFRASKPYFWHALSFSVMQYVVLRPLISIMGIICQYYRVLCPEAYSIHYAGVYLDTVDFVSISVALYGLIVFYVLCKDELKGKKPLNKFIAIKLIVFFTFYQSFLFSILQSHGVIKATAMWTATNVSDGLAALLCPPPPLSPLSLPPYHCCKEYKLIKNFPPTNSTDPSKNPHHQRETRSNFKTYLQAIWDTVNLSDFGVEVYRACRFFVNYARGKPGTHSENTMLQRTFMPDSIPYQSQEIGMINKHFSSNSSTVDASGNASGDASPNAGGGVGGGWGQSYAQEGGKGKGAAPMAQTQPSSYAYADDQGQATQGQGYHHQSPFTQHQHQDSQGHAMHPSSSYEADSPGPGEYRRVEMDRGDPFVTATATDAVFPEARPTGTAGTAGTAGTGQEEEGGRGQTLQGGWSGETQVEARDLGSGSAHWPEARPLGKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5F9</accession>
    <name>A0A1E3K5F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">L198_00105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035237.1">
        <property type="nucleotide sequence ID" value="XM_019172295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5F9"/>
    <dbReference type="GeneID" id="30189320"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="33976" checksum="53BB837BB9D6ECF6" modified="2017-01-18" version="1">MFHSKSPLTPNNTLYTPISRVPPTSATHRSFPQSPAAHSYPPTPRPLLENTVSRQPKEPKKKRKRLKWTKVRSILYHSSFWFCVLLNAALLVAAAWGMGAQAWRTGGQKNWNVLVVVLAYVITMLKTMPKPYIPTKPDDVPPKVANHIATEYSRTAVISHISQATTGQQEGWGRPGTKWEGKHFRSWILGSVSVMREALGVKDDLSYSPLSYQPFYNALKRIPSSSPQNPFESPSSSSTIPPQEDTGLRVLLNSWVKYIEQAKYAKREPGEREAGAVERLVEIVLLTMKIKEEKGNTSAQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5J9</accession>
    <name>A0A1E3K5J9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035277.1">
        <property type="nucleotide sequence ID" value="XM_019172335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5J9"/>
    <dbReference type="GeneID" id="30189365"/>
    <dbReference type="OrthoDB" id="2564192at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130786" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="17539" checksum="F886E1F58015990A" modified="2017-01-18" version="1">MIASTLLALLPILGLTSAAVVPRESAKFGRLLQWDDLTLCVKANDAHIGAAISFGSCVSNGTEGYDLQMWNFTNSAPFDNKVINLQAYPDLCIDAGYVPHNGGKYSLQPCGWNPAGQLLSYASDGLISTSNGICMRKWEDSKEIDQHECADKVDHELTFTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5K4</accession>
    <name>A0A1E3K5K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035226.1">
        <property type="nucleotide sequence ID" value="XM_019172284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5K4"/>
    <dbReference type="GeneID" id="30189309"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130771" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="421"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="537"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="653"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="757"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="854" mass="86449" checksum="6E1315B06CCCFDF4" modified="2017-01-18" version="1">MSPVISLLLLASLVNGAAVHPHNERRFLWGSWSFNTDSRQDSSSYWSNSNGWGNSDSTFSTTSPQAATYLAQAQSGVSGLHQGWSAAGCYDDSFNARTLASASTSSWWMTYSTCTTFCGNRGYTYSGVESSNCYCSNSINSASSIQPYYKCSGICGGNWFEDCPRTNYINVFTNSKTTTSSSTAKTSSTFSPTSTSIAKVSITSPSASGSTMKSSVPALASSSSTAAESSIVPIVDTSVISAAQTIISSAVSSVASEASQVVSSVSAQLNTTSVASQIQSVPSQVSSAIPAINTTSVVSQLQSVASSVVSSVEAVPTSVASSVISEVSSIASGASTQVIPAVANTTSSVASDIANATSAVSSIYSETTEAASSTVSSVASDISSAFSEESSAVSTIAEIASSVTSSAAAAASSAVSSLPTGWEVSACIAEGTSGRALPETSTSSSDMTQSMCASFCSDAGYTLAAIEYASECWCSDLLQNGASLTETSSACTMSCSGDSDEICGGPSALTLIVNTSAIASLNDDLTAGIVILPTNWSVPSTSCIPEASSGRALTGSSYTSPDMTLATCASYCTSEGYGIAGVEYSTECYCSNMLSNGVSLNDSSSSCTMTCGGDGTTFCGGSGALSIAVSSTITSKLSSDLTTEITTLPTGWSAASSPCISEVTSGRALAHASTASDDMTIETCLDFCNAAGWQYAGIEYGRECYCGDYLANGASLDLTATCNTACAGDDMSICGGGNALSLYVNPSLALDLTVVLGYHLQGCVQEVTGRLLANSSYTSSNMTVDACVGFCSDEGLSLAGVEYGEECYCSSALTSSPLLSTECNMACAGDDSQNCGGADAIELYLAAGSVLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T5</accession>
    <name>A0A1E3K5T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035306.1">
        <property type="nucleotide sequence ID" value="XM_019172364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T5"/>
    <dbReference type="GeneID" id="30189394"/>
    <dbReference type="OrthoDB" id="2575354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="942" mass="103989" checksum="5DFF31C834163A4E" modified="2017-01-18" version="1">MSAPPLLQPQNIRPPRDHAHHPAQPERAHSSSQHARTNPPWPVYYPVGGTSYLLEGTGIFVDPRTGVGLSVWIDPSLEDLYGLIKVIWKEGGHISPTPDSPATQLLLVSPHQTPTLERYSHPERLPSLRHHNINIPKEPLPGRELAWQVKVMLDRCWIHRCLTAGHFVGYKDDWGGCRIGGPPAHVKMYPLEPMRWLMRFVDGGLALDGTGRAGGEISRDAMRREGDDSDEDILALPGPPRVPASRSNVVGNGRPRVESAVSSSSRPVAQQHNTGTFNRNPNAGPGPSRAAGAGAPTGSPAPVLPAKPKTIPSPSKYESPSLHPTLQGYTSAKSKPKPLPSQNSSSAVPAQSFYQGSGPRPSNKGKTPARDEEQSAESDSDVGAYESDGDWPTGSQVPKSDFVSRETTTLSELDEIMTIERMCLGPGIRDSYFIGLLRKKYGAYSYAAWRDIYICWLYQNGQFSYLSASCPDSLEYSTRSAQRPIQADEYHDDTPRYIPMEPSTLSWSDVNHVFEKENEIIWNANLNLDETGHYLGDKYGVYLGSTWKAYFTRWRKQKQGKLIDEDEQEPAPKAPVKPAVQRAPTVIRPTRGPKRKSPYSPPPPAARRKPSPPSQQRFPGPSRRKSLARPMVDTGEESDLDDGAKDIDSDDEPAVKTGTGQGVTEYMTNETLCKIFEERDAEWEGRGASRSEIAGWLEKEIGVYSVGSWQIYYNNWKTKKGRFIYLAKDTKPKPSPKVVKPRPSLVPPAPPLMRAAPRPAPRKSAPRAPAVSTNPQPSASRPSIGKSPAQPAAKPAGPKKQKKPKVAVVPKKSFTDEEEKAMAQYVVNYNVTTVLPSYLTWQGWAANPRGYPKRTPTSYATHCWKFRDRMEALVAQFKGTPNDTRWHGQLAKGGPGTKDKDRTLTVDPSDRLAMAMALAGVDMDTDEEEEVVVDADEELESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J3</accession>
    <name>A0A1E3K6J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00432</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035554.1">
        <property type="nucleotide sequence ID" value="XM_019172612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J3"/>
    <dbReference type="GeneID" id="30189645"/>
    <dbReference type="OrthoDB" id="2564707at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="15">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO08699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="47843" checksum="2DAA2CF08A97F197" modified="2017-01-18" version="1">MPIAIPTQKPQASTSGPAPTSSAAPVQFPRNPARLAVATRDTPSGPSSRPVSSPRRVSQPTPVPADASSTSQIGEPSEAALKEDAETLKRARVRKAQLQKKVERWMDLLSEDTVEREAFKKAAAHLTPPQYHEILHERHLNSLCSYPLCPNPPTAPYSSRRKFIISTSKRSIDPASGNEHEGFCGKKCTARSKWMERQLRGEAVWLRDLKGLGGEGGGVELLEEVEERGQVLSLHDVVGRRGSEVSANAEETAPAPTALRPQQVIAPAKQPLPADAAQVKPGISAVTALIDSLVIHERPVSAPGAPQTAKQVPVAQPLPLPLPLPTSVKSSRALNAREQRRDQASLTTPPAILTRSVLSAAQSVSSSLPAASGGADSSNSSTPGGKNRNRGGPGQESEEEESDEESDWEKEMKFGPEDDEMRALFEEAEKAREMALDGEGAVKEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6K0</accession>
    <name>A0A1E3K6K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035546.1">
        <property type="nucleotide sequence ID" value="XM_019172604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6K0"/>
    <dbReference type="GeneID" id="30189637"/>
    <dbReference type="OrthoDB" id="3192156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="31375" checksum="B846E6477E144665" modified="2017-01-18" version="1">MDASIAVAHATLQPLLAPVHPLYCPFPLIDLYGAMRLSSVVNWIASGAFGPPASPPKGAKGKRGKGQVAKRARPSALQEVAGIMVVVFGGETFLAMSTNTSPSWLVNPSYALLFGLIHLLQTRTPFIHLLPSKPSFLLEILLATPDAIGRTLLLTRFSVLPLLASTSPKALPPTPASLLLVPFILAVPFASLIFSATSFFTPTPHLSTPDELKPWGWLMVDAWAPVVVPAVFLSLIGPVQGWEFGLRWAEYEAVVVCMVGLSVVFALRAVYNFGGGKEVWGQLVEEEKVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6R0</accession>
    <name>A0A1E3K6R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035685.1">
        <property type="nucleotide sequence ID" value="XM_019172743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6R0"/>
    <dbReference type="GeneID" id="30189776"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000096">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115624" checksum="0C53EA42C05B5B67" modified="2017-01-18" version="1">MDSNAIQIAVRVRPWHPEKELPFVQKATPQPFFQGDGNFGQSPAKVATQGSLREVVEVVDHRMLDFDKPQVDMSAGRRTGPIMGRRYKNRKYVFDQVFGMEASQEEVFAKTAKSLLPGVVDGYNATVFAYGATGCGKTHTISGTEEQPGIIIRTMRELFDLVEETKDKFDTYFEMSMVEIYNETIRDLLHDDYPSCPHGGLKLLENEKERVTIDKVTLRRPTSVEEVMELVLLGNERRSTSFTERNSESSRSHLVLQINVGRNERGTDIDVANSVVRQCSTSATLSIIDLAGSEKASVNRGQRMKEGANINKSLLALSSCISALCQRPVRGARVHVPYRDSKLTRLLKFSLGGNCRTVMINCISPSSRDIEETNNTLLWADKAKKVSTKVSRNTAGVELRTAQWLQKIVTLEETIKTLRGQLNNQQSTKSGLQQKRLDKATVESEEELGRVQSELDALLPVIVEGSEMDALWNASVLQVEALDARMEDIGVEVKGGRPEEDAKREKDHLRALIQQQDDSFRFNNEIQAGVQSKSLKHITLANLLKKAEERQFGDDMSEAMYKHQLKVAEHRAHIARSVAAARERGLRDYISQQAEALTKAASTLSRFSTTIRSEAAAVDSLQSLDDLAAFRGRMHSMGRQVDHSVAAVFGTDTPHPLPLPHNLLPLSIPAPSPRRASLGRHLSRPPSPKSGLRKTPFPAPDAPKETKKQLRWPDQTGEGKIDDRSIALDCPVFTSPSVSIDGMGSAADRSLDIAIKDEDRSELVPSALRPDPAPTAAFANTSLLSSLATVKGTEDVPAWKQMRLERGLGSQADNSGDLSVSSNSPLGASKPGTKGLSTKLHRPGPLGELSLQIPAHPSPPSTSSVTNLHKSSITSAGKAGGSSAFANIKISMPSSDGTMPPPPVLGHRRESMIGPARHDRPRQRLSMIPSHGETSFSGFSHLGKGLPSGMSALSGGAKRLGSDGKRRMSVQVGHSTSTGSPPVRGPALGSRPSMSNFKAAASSPGNTSGILSASRGLSSRASVSRLNAGDTYAIGAIPRPSLSSRPSMARLNAGVAVGDATGRPAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K711</accession>
    <name>A0A1E3K711_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035640.1">
        <property type="nucleotide sequence ID" value="XM_019172698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K711"/>
    <dbReference type="GeneID" id="30189731"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="69726" checksum="7144D92BD6BCB10B" modified="2017-01-18" version="1">MSYGAMTGISFTNGGGFSFEGKPKSFKWGNGGMMGSFGAKYYGDAGGDSPMIPFSSSITMEPSSFAASAHAFGLPSGSLSSSYHRRSYAAAVSGRDAANLSTSFASMSFQPMSLGTSYNRSQVQGLMRSDAELTKAYECCNKTHSGLHALLEHVEDCHPFADPNMQPEDTFSPVTHAMDLDLEDVEEESVPVPASGSSHASLSPHSAAPVPVPNYPLPKASPTDIGNKSPLKLSDVLKSPPDGETLVRPSNLTLTRTQSSSSSPPEGSIATPTASTHPSPNFIAPKMNPSRPAFLGSNAMRPALSQKRFDRAFNEVVAGKKDDVKSDVPTAVAPGVLFASAVSSLGIPTVPPGTKTEQPATPAPKEGETPTPAEAPKAPSAASTPGSIDPAVKPAGTPTSAAPTTQNKGIEAALPQPSLFSSHKPWRCPNPGCNKAYKQSNGLKYHQQKGQCDFAIHDAVDLGLTLEEAEERNRPFVCAVGAGCTKRYRQMNGLKASLSQKFYHYLNSGEHGLYGLRMLQNGTHPHPPSLPAPPAKARPTPLPSSTAHGNAPISRPTGAPYAIPSHANHAPHPGQQGRVVGQGPGHHPNGHGPPRMGTWPAQRPANGVSVPNPRPNGHPHAPPRPQARPPPQPQPQPVTKGRDAVLFSAVGSEDPMDIMSRMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9R1</accession>
    <name>A0A1E3H9R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000072">
        <property type="protein sequence ID" value="ODN73092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027746.1">
        <property type="nucleotide sequence ID" value="XM_019180272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9R1"/>
    <dbReference type="GeneID" id="30197517"/>
    <dbReference type="OrthoDB" id="2569417at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27981" checksum="5A29CCB3A1ABD274" modified="2017-01-18" version="1" fragment="single">MSGDDAELTKSLNHLDVKDAQDTDASRTHDDGDHRALSFSSTPGSVAAGSAGADRLTEVTRDVVSSPPTDRTPDTLPSSIHPDFSVQTNDDFLLVTDDDVGFYVNKEFLLEHSEFFRDFEDMDSDIRQDEDAWKGRTQAVRRDMPGALSNGLRVVLLKVKETKSWPDAYDRKRRVFRSQRIWEYDHEDLALAFGIANQYGFTRFSAQARLSTPKTSTWFRYLYVAFEADETVAKAIAKSTLYFELTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ15</accession>
    <name>A0A1E3HJ15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027940.1">
        <property type="nucleotide sequence ID" value="XM_019180086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ15"/>
    <dbReference type="GeneID" id="30197326"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN76339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="31042" checksum="769CBC7F4489DE46" modified="2017-01-18" version="1">MSTFSRLIRFFPKSSPFKPLIGQPVDPTLDVGLATYNRTPVEVDVFSGASVLSPGTSTGRREVVDRILSPLAQHEVGTIRCIGLNYTNHAIECGFAIPETPTLFMKPSTALADPFPATTILPKAFLKDDTADYEAELVIVIGRACKNVGEEDALDYVLGYTAANDVSSRAAQFAQSQWCYSKSFDTACPIGPAIISKGSINSVGDLSIEGSLNGKVVQKSGLDDLIFSVPKIVSFLSQGTTLPVGTIILTGTPAGIGHASQPRVTLKEGDEFRVHVSHGVGTLINKIEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7X8</accession>
    <name>A0A1E3I7X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_07618</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028376.1">
        <property type="nucleotide sequence ID" value="XM_019179608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7X8"/>
    <dbReference type="GeneID" id="30196829"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="67"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="248"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="417"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="426"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="59205" checksum="4EEA70FC72D9D708" modified="2017-01-18" version="1">MASSSTSHNSDWKSSLTAPPKDYRPQTEDVTATQGASFDDFDLRRELLMGIYTAGFEKPSPIQEQAIPMALTGRDILARAKNGTGKTASFIIPTLNRINTNLPHIQALILVPTRELALQTSQVCKTLGAHIPGLQVMITTGGTTLRDDILRLQQPVHILVGTPGRILDLGSKGIAGLNKCGMFVMDEADKLLSEDFMPVIEQTLALCPQERQVMLFSATFPWTVKEFKDQHVVQPFEVNLMDELTLKGVTQYYAYVEESQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKVTELGYSCFYSHAKMQQAHRNRVFHDFRGGMTRNLVCSDLLTRGIDIQAVNVVINFDFPRTAESYLHRIGRSGRFGHLGLAISLLTLEDRHNLYRIESELGTEIAPIPAVIDPVLYVAPAMVEDERPSPPPVRAAIAAPRQQQSQRRSPAPAQQQQAAPPQQYQQAPEVQSPPVQAQAQGQPPAQPRAFSNQAQGQQGQQGQNRRPQNQSGNSNPNLRGRGRGGGGGRGGRGGQGQSQGASPAPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB96</accession>
    <name>A0A1E3IB96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028577.1">
        <property type="nucleotide sequence ID" value="XM_019179436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB96"/>
    <dbReference type="GeneID" id="30196647"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="13431" checksum="ED752C36EE98D684" modified="2017-01-18" version="1">MKLVRFLMKLNNETVTMELKNGTVIHGTITSVDPQMNTHLKSIKLTLRSQETISLDSIAIRGNNIRYFILPDSLPLDTLLVDDAPKPKKRKVGADARGGRGGARGGPGGRGAPRGGPRGGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBQ9</accession>
    <name>A0A1E3IBQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028603.1">
        <property type="nucleotide sequence ID" value="XM_019179462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBQ9"/>
    <dbReference type="GeneID" id="30196677"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16245" checksum="96BF7B7BAC88A154" modified="2017-01-18" version="1">MEDTRAFLDTFSETSSHTSSSNDDFVIANGRPPQDEFELEDEYRSDAGLTGYFPLEDDIQQLTAQGTNAIMTQMNHLLYEERVRMAPGYTVLESAVTIPAGDSPPADTQQHLDNDDAASIDDSGPFDPYDEVEFDEQASSSEEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID31</accession>
    <name>A0A1E3ID31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028725.1">
        <property type="nucleotide sequence ID" value="XM_019179244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID31"/>
    <dbReference type="GeneID" id="30196447"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="607"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="675"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="773" mass="87413" checksum="AA72F3FF0BAE3355" modified="2017-01-18" version="1">MPRNIAVEDNLYLDEAEEFILEHAVVASPPRSWRPKPTPSNPPTTSTAPPERTTTTRRKMDWTEEVKAHPDEPLDESYWKKGKRRASGVADDYEVGDEEGGADQERCIICLMGLNDRTIVGVCGHEFCFECICIWSNQSRKCPLCSGDMAPFLLHDLDAEAPTKYYLPPLPSKPAQETIRDRLPTRQERARSGEPIVPDEVDLQVARRRQYYQHELYVKHMGTNRHSRFRPNPTPRQISEDPQLAQRAQAFIRRELRIWPALDVEYLTTYILSLLKSIDARSEAIVRLLSEFLDTDEFPSAAEHFAHEVYSFMRSPFSYLSEYDEIAQYDPIPQSLSPRGRSPLPKALSPQGRSRSRSFDSLSSRSYSHSRSPSPYSDYSRSRSYSPRPRQRSPYPRSRSPYDRYRSPPPYNRRPLSPHRGGYRDRDPYVNPGWTAQLEARERKREKNILKRRRREERRAEHARARQVVPPNGWGQAGQGSGQGMKERVELLPSPPKVQRPLDEDVEMTSSAPSLSSRLAPASRDMQRQAPPHLASRLSIKGAAAARQGPLGKVSINEEIESRRLSLKERLDKARADAEAKKSAATEGMDAVPAVKLSLKERLERAKAEGAKRYAGIASFTPPPTSLSNEAGPPSAPSVPPKPVRTNSQGDTKQGRRGKLQLRLKLEHERALMRASAQAPPAATPTPSITQPTSRPSQSPLPSTPAEGADQGVEATMEKALKRMTEQERQREVRRRLMVAKLKAAETDQERRARELKVRLMERKKGVEPGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID42</accession>
    <name>A0A1E3ID42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028735.1">
        <property type="nucleotide sequence ID" value="XM_019179254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID42"/>
    <dbReference type="GeneID" id="30196457"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN86552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="41149" checksum="84ACA4C47B5022A6" modified="2017-01-18" version="1">MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDQLSGTSVAIKKIMKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDVWSTGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPSDDVIQTIASENTLRFVQSLPKREKVPFATKFPNADPTSLDLLEKMLVFDPRTRISAADALAHEYLAPYHDPTDEPVAAEVFDWSFNDADLPVDTWKVMMYSEILDFHNLGDISQNEAEGPVTGEVPAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDC7</accession>
    <name>A0A1E3IDC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028753.1">
        <property type="nucleotide sequence ID" value="XM_019179272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDC7"/>
    <dbReference type="GeneID" id="30196475"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="55880" checksum="44E1D3ED501E6928" modified="2017-01-18" version="1">MSHNSGVFPGFPSPSPITYTTTTTTTNNNTSSYGNAPGLQLYDISCVFPASSTPSTINYTSITNDDGNVLGLQLSALTPFPASSGDKPKPKARSSTHVTNTNNIKARGKEKKKHAEGYKRKSMSCEHCRQRRKQVSILVSISPSESDSTLQCDGDNFNACTLCTYNGIECKYNVAKGKRGSQKALKKLAAMGRAPSADGIIIATPSTLSLASSSSTSSMSPITPITPAKSTVELSSGHSPASVSAGHTSGFPNPQTFMPFVPTTQVQPPVSQLSSAVDSNGLLAGWQIAQLQQALLDRVDRCFSNSAAATAASEFDPYEPPTPRTTPVKPTYVRPTDVSPIQAPTFSLLNASVPSTLPAMDVTRPQPQLPAFDPQTLSESERLEMEKLAMNVVFDKGSFSAAPEAPCEAAPVASLATPDTTPLKPTVEMSAVSINLSYADFSEPQPTPWLSAPQIQVEDEAVPEDEEDVDWGMYVNMEEMEEVDDGGSWGALESPFNNTPFGDSFTPIADEAADNGMRGLWNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE38</accession>
    <name>A0A1E3IE38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028852.1">
        <property type="nucleotide sequence ID" value="XM_019179235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE38"/>
    <dbReference type="GeneID" id="30196437"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="51"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN86860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="61140" checksum="F6E9BB046B8997DE" modified="2017-01-18" version="1">MSVVHSNEEYLPSSYDKGEKGEQYVYQTETGEENVIPREEETHRALSPRQLSMIAIGGTGLVIGSGTSLARSGPGSLFISYVVMGLTCCGVMMALGEMSTKFPSRKGFAGHATRCVDPAYGFATALVYLCKYLIISPNQIVAGALVIRFWNDSINGAVWVTILIAFVISINCLGIKWFGELEFWLSFIKVLTLTGLILLALIIDLGGVSGQERLGFRYWEDGKAFLPYKTTGNVGKFCGFVNALVLALFAYMGTELIGVTVGEAKNPRRTVPAAIKKTFFRVIFFYMLCILLVGMIVDSQSPLLAQAAKKGTGGGASASPFVVAIQSAGIKVLPAIINACLLIFTISAANSDQYIASRTLYGMAKDGNAPRIFTKCNSRGVPWVAFIFTGCFMGLAYLVASDDALKIFNYLVNTVTIFGGLTWVSILASHVAFMRGMKAQGIPRDTLPYKSPLQPYLTYCALFMTCLVCFFKGFDAFMPWDYKTFITNYIGIPVYVIGYCGYKLIRRSKAVKMHEMDLSTGAREFDDIDEDEEEEMRYKSMTFKQKVIYKLRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEG7</accession>
    <name>A0A1E3IEG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028817.1">
        <property type="nucleotide sequence ID" value="XM_019179200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEG7"/>
    <dbReference type="GeneID" id="30196399"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="12">
        <location>
            <begin position="547"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN86825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="848" mass="92258" checksum="1B873B9249F39C3C" modified="2017-01-18" version="1">MAVPPLPRVVILDYYDSYTNNIVTLLAKTYTDEQVLNNVVIIKADKYTWEEFQKEVLPNVDCVILSPGPGRPENPADIGFALDLLRLHPVPILGICLGHQAIGYAFGGKIINTPKITHGHVIPIAPVQPPLGLFASPLWAPAEQQKDTFDVVVYNSLAVDPSSLPDELEVTAWSVPTPDRPSTIQGLRHKTLPIWGVQYHPESISSTKGSPLLLSFLSAVHAHHESPASYPPIIPPILASCSYRIHPSASNPPSHPSHNPLPRLSLVSHPFGSTGQEQTTDDIFNLFIRSNKINESGIGEIWLDGQTPLRPTTSSLATPSFLLTYSLETRAVRLHRKGLAVETYVLEDGATFWQAFADLQTALSSSLFASASYSSPSVEEEEDEKDVWKGGWSGFFAYEMKEESLPGYLRRPPTSLSAITAQAEGEVEEVDACWAWVDGFLQRTPGGEWVARGILREESEDGGEREGRGEGGGRGLEGWLRKQGVEFGLSAAQWKTHLERISTALSSPPSPSPSPPSPAQAPVQPPAPESTKPSAFPPFHPTSPGSAYKSSIEHCREAIRQGESYELTLTTSFEGDDELFEMYLHLRKFNPAYYSAYMHFATLTSPSLSPSLSPSPSPSPSSSSPAYQAKPAKGLTILSSSPERFLSISSKREVEMMPIKGTRARCVRVGREEDERRGRELQEDIKERAENLMIVDLIRSDLLPPCLPSSISVPKLIALESYGVHNLVTTVRGKLYPPSTASPGGGEMEAIARCFPPGSMTGAPKLRSVQLLDGFEKGKKRGVYSGALGYVGVDGVVDLSVVIRTIVRQGDRLSIGAGGAITWLSNPQGEWDEVLTKVKSVVGELEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEU8</accession>
    <name>A0A1E3IEU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07122</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028894.1">
        <property type="nucleotide sequence ID" value="XM_019179136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEU8"/>
    <dbReference type="GeneID" id="30196333"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="98" mass="10714" checksum="748F627CF4C912D6" modified="2017-01-18" version="1">MSNFAKQIPKAVREIRLQFCQSSAASAGVRQFVQSSYPAVKASNPDLKFLIREASNVSPRAFVRFERGVESEAQLANLSDAEVGKVLSTLVNQQTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEV1</accession>
    <name>A0A1E3IEV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028918.1">
        <property type="nucleotide sequence ID" value="XM_019179160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEV1"/>
    <dbReference type="GeneID" id="30196358"/>
    <dbReference type="OrthoDB" id="10351564at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="42433" checksum="540B4C69F3B384F6" modified="2017-01-18" version="1">MSDEYLSLQHIPSFPPSSGTTKRSSMSFSALLQGCQDNELDVRLFEKNTISGLDPTSGFSSISVQSAGLSGEAVPWNQYNRETWGDDAAMAALVPGMFRHAAGGWKRLDADPHLSEWIAVSVDPIWALFCAAWRLGLGHQQQVFMSIIRMPGDHDPENPLIVVNPLQEAKKAGLDTTRAELFSLDPNKLRLAKNCLAKFGTELVYRRIPIEYIVETVELTHNSIPWDDIPLGWFRGGADPSSQSHYGWLYCLSFDPFSKDTHYGDAQIAILDEKRSIEKAKEEEESQWDSQREFQEVDTESSTGDEDGVDLGEHEDAFQEVGLDGVVEEEEDDEGEGEASEALVKTEDGKPHVAVKHEHPEEEDEDGESKGVKREKFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEV5</accession>
    <name>A0A1E3IEV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028901.1">
        <property type="nucleotide sequence ID" value="XM_019179143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEV5"/>
    <dbReference type="GeneID" id="30196340"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000011">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="239" mass="27135" checksum="FCBE7BA2CCA863C3" modified="2017-01-18" version="1">MSSQHIYATPATTAAPETVKLTTHNQYVTPRLLAGDLDPSPLLQFNSWFASVLNPTESEAAGGRKVHEPEAMTLSTATARGIPSSRVVLLKTVDKTGFVFFTNYNSRKSQELIANPYASLAFYWREVSRQVRVVGKVEKVSREESVEYYNTRPRGSRLGAWASEQSKPVQEGELEKKVKMQEQKWEGKEVDCPEFWGGWRIVPFEVEFWSGQPSRLHDRFKYTRAEGSSGEWKIEKLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEW3</accession>
    <name>A0A1E3IEW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028668.1">
        <property type="nucleotide sequence ID" value="XM_019179312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEW3"/>
    <dbReference type="GeneID" id="30196518"/>
    <dbReference type="OrthoDB" id="2564695at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="923" mass="101708" checksum="DFE0A7CFA8031930" modified="2017-01-18" version="1">MSTSLAPLPSSSSSSSLSQRRSSLPAALSTPLPSTPSARRPRTSKTPLSVQLFQKKHLSEFPHLYSIPDPDEQERLMEQEREALEEARRIGRFMRESILAKGEELVSPVQTPRGVSRPLSLTADKPFSLAEAAEISPFDPVEQLSSQKAARGSFDDVNRRVPRPLSLLTGKPLVTPSARVTSPTQELQSSGRRPLSLLSRRQLESRPMDLVRVSEYTASDLSSANSLAPPVKYDMEQRTPDLSTPIFSDTYSPDPTIVTPGRAHIGLALEFQSPNGESAADEEEPSSSEANTSNSFRNSTYSWATSFSGETEELRTAAQYVPSRASRENSVEKEEVLGTPDRAKQRRKRIVAIAHTARQLEGVGSREVEDPTLYSKLVKAWNDRPGVMPTEPVWTPAEEVPPLLPTPFSEVPSHISSESSGPFRYSLASSIHDLGEEGAVERGAQILSEKAWLKTPLYSSEAYFGAHSPSQPFPSSSFVPPKRGRDVSNSYEARESLQSEESEEERGPPVVTPKRVVRRVKTDISQLKDAKMDPSSFPEMPPTLGLGFSGTWLMANYGVGSSRSAAGEMGPDFQHGEGGVEIKEAKKGYKHHGSIHSLGDLVPQSPRQPQPPVTEGNSLETIDLTLSASRPTSCYNTPAGRRHRQSLDCDLPPPPPPARVRQSTDYQRSSLSRQPACWTPSITSLPQHIEHQHQLAPPIDLHLPRTRVAHGWDEMPSPPPIMAGMGEEIDRSETEEGEWVEDLGSYRSSVIYSYRSRSPSPSQSPRLPIAQSPIQLQHHLQVRPKSVPPTTPVREEDHLAFPDMLNMPAREEVGRERGEERAEGVLRVKNRRPSCGPSSYPDTSAMGGAREGMSEGDNYDPEKATVSSKSQTSSILFVFGFLMPLLWLVGGWLLPSSSTALYTTTEKSARIPNWLYHPHPRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFR8</accession>
    <name>A0A1E3IFR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028979.1">
        <property type="nucleotide sequence ID" value="XM_019179061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFR8"/>
    <dbReference type="GeneID" id="30196254"/>
    <dbReference type="OrthoDB" id="10340126at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15193" checksum="F164794F35BF4422" modified="2017-01-18" version="1">MMEDSNDGEEDEEEDWACVSRINFPECGHTAMVDRDLTGCILSWCLSEHSDAFEASNGASVRQLKELGYGQEWKTSLGRVTSANVEMGEMSDSGNFFNSFLGDPELVVNSSMSEEEVHSLVERFEETCGSQTSKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGL2</accession>
    <name>A0A1E3IGL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029082.1">
        <property type="nucleotide sequence ID" value="XM_019178988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGL2"/>
    <dbReference type="GeneID" id="30196180"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="12931" checksum="D2A83689D73E8784" modified="2017-01-18" version="1">MSAENTQAQVPLPPKAGEKIPQAKVDEEEEEEDEDEDEDDDDEDFDDEEEDDEDEDEDSEDDGVDHKGVLADFYNNEQQDEDDDGDVVEGDEEAGLTPLKRKANEGNDGDAKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHI3</accession>
    <name>A0A1E3IHI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029120.1">
        <property type="nucleotide sequence ID" value="XM_019178843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHI3"/>
    <dbReference type="GeneID" id="30196008"/>
    <dbReference type="OrthoDB" id="2575369at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="47521" checksum="8A5EE6EAB2EB2AF1" modified="2017-01-18" version="1">MSAPSPPDSPRSLPITPQDEHTAMILPPSRTTAKAPAFIALPAPSPAFNTFVFPPTTSPPARSTPSLDALPNEEFVFGNCPAQPFLGTPVAEQGPFEYPDLVGSSSPTYSSPRSSSFRTRRPLSISSQNSLHSEPVSPPKTRRGSTNSSIATLPTAWRPSIVHSATVEGTVPVSADTTPCHTPLPPPLALPRQRTAAFMYQQKAMPAPIPPSLLARRGSLPAAQLFGLPLHDLQNRSKSVNHGPVMTAASLYQRRQSVVSDSEVNPPLQVVPLPTFNPERRPSLPAISPSLAFPPRITKVSRSTSISHAPRRPLSSLLSASPRTRQHHHLPPPLGIPPSPRSSSHGRLSSTTSSDEDEPETPLPRVPRLDQPAVVELWGGEEEVESPVVAMSMEGEVKKALPDPMPVIGGDEVALLETPGLETVLERPPLETIESGDSVETVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ72</accession>
    <name>A0A1E3IJ72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029304.1">
        <property type="nucleotide sequence ID" value="XM_019178821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ72"/>
    <dbReference type="GeneID" id="30195979"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="381"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="687" mass="77700" checksum="709E26CBAC142281" modified="2017-01-18" version="1">MGYTSEGSGEGSDKRVKRRAPKKSPSVVRRACDACRRKKVRCEGPMNSLTNAKCAQCDHFGVNARVWKKHLGARIQQNRGYDRMLEQRCSRLEMMLQEVYPDVNLDDYVGPPLDFEDFDLDSYQEELRAFSIPGYPSLKPLHPVPSPLPASPSSPEPSNALIDSVSFIRESDRGKSLDEIEHTGDDSVVVVNSLRRLQYQHVRWRHHGRTSGSHLVRHYQDLKQDAGESGNIFEKLSKDKREDFWQVPEWEQFVSDVGQNALDYLIWPENGLDQQLINAYFETFPSSIGISFRRSTTRACGKASRGLGVATGTFWPRGLSATQGQNRDYDEQWLPYSAGWKYLRMALHMGHNPLYMPDLHELQSQVLICYFLQSSTTPQMSAHLAGSALSSSQEIGIHLTTVLERLEPTERELFKRAFWCLYHFDRFSCAMVGRSVAMTDNDQDAPFPEDPEGKGKVSKVAMFIQLLKLDQILGKVLYSSRQEGSRQATRRTSAIELDLALEEWADNVPEALRWDPNCSNFTIFQQTSCIWGYHGFVKMLIHRKFIPPKRKVGTIDQLSSLTSISKAVLQRGRQEDCQPGHCLDVSFRLLSWLAGTILPVSIYTVEQTAIERQAAEDGIRACLAASRELEIIWKQGGKFLKETETPNPRRLGDGSGGDPKGPKESMYFTPSTETRGVCLGGTELYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJM0</accession>
    <name>A0A1E3IJM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029355.1">
        <property type="nucleotide sequence ID" value="XM_019178654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJM0"/>
    <dbReference type="GeneID" id="30195811"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="47817" checksum="2B1DB1EAB896A3F9" modified="2017-01-18" version="1">MGRLGGQMNYVQLEKLGEGTYATVYKGRSRTTSEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLHDVVHTESKLILIFEFCEQDLKKYMDVHGDRGALDLNTVKSFTHQLLQGIAFCHDHRVLHRDLKPQNLLINRRGELKIGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDIWSVGCIFAEMITGYPLFRGRDNADQLVQIMKIVGTPSEATIAQIKLNSPEIQIKAPLAKHPKQPFHAIVPRAPRDAINLLEHLLQFEPSRRYDAHTAMQHPYFTSGPIAPPTLYDAGASALSRAGGSAGVGANGQGMSASSLALPPSVAARANQASAAVQAQQAAQAQAQAQQQQAQQQQYNMMMAEQAAMQGYYDPQQVQAHHHAQAQAQAQAQAQAQAQHAAQMQQMQQGYYMGNGGRQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJX4</accession>
    <name>A0A1E3IJX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029376.1">
        <property type="nucleotide sequence ID" value="XM_019178675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJX4"/>
    <dbReference type="GeneID" id="30195832"/>
    <dbReference type="OrthoDB" id="2563899at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129826" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="21721" checksum="9E3F2DF9BB55CBD9" modified="2017-01-18" version="1">MRFTSILVAALPILGAVFAAPFNTEAKKDLSLAPASSELVERDGLLLGVLADLKADVTAAGSLTSLSAEADINACIQVVIDAFNKCGSALGIDLSLGVDARVGLDIGLLKRELEERSVNKQAVAQALVDIIAVINVNILIPVKPKLLTCTCSQTHSLVTELDLLLTGLLCALEAILGGLLVIVKGLLITVLGLVSVLLGGLLPSCLAVCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKS2</accession>
    <name>A0A1E3IKS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase regulator 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029477.1">
        <property type="nucleotide sequence ID" value="XM_019178570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKS2"/>
    <dbReference type="GeneID" id="30195727"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="84822" checksum="A4C9F396A1ED8AD1" modified="2017-01-18" version="1">MSTLHPNNAYYQGPSPVPPPRPHSAYDYHQQQAPQLAPAPPARPSSAYIAPYPSAADQPRPQSSWSHIEQFSTYGSSYQPAAFEPPIQAFEDMRLVRPQSQSAMQSRASHASYIPQQGAPLDNVMPGSVINSRSSYIDSPVSAPLPQAAPPFEAWPLPNPTHRLSLQTEMQPHMAPPPRSSSLNNLSPGTPTLPTPTQGDTPQVHPYPTVDKLTQASATIERTSDVSQLMWCQDVIRLVERHWHQSSDMSSHFDRPVSPPPNSSHLSPRLHELLGKAAPLIIALSTSEDTRTSGVALYLRGKLSSSGVCPAMLPKDARQAFKDFDVSARQGEARSWYRLGKDYEAVNDLARARDCYDRGAKRSECESAFRMGIAYLRGQLNLPPNPSLGLQLLHQASDTSTVDFPQSSYVYGMLLAGELSLQADIPPHLILPPSSPATESFLSQQVNARSAIERAAYFNYPPAQYKVGHMYEYAALSCPYDPAQSVAWYTFASLAGETEADMALSKWFLCGAEGFFVKNEEKARVYAEKAAKKGHPSACFALGYYYEIGMGCNAAKLGNADAPGRLAALSQANPSTMTITEHETRLRNTIIRKHTTAKNRSDRFSISRSGRAPEGQGGQSSGAPVLGVQSDFAQIHGPQPGAPMQPQIQPIAARPGEIMSPIATSPPAPGSNFRPPMPMSQGLRGPSPSAYPSGAAPPAVPRPAFSRQNSNNSVNSYPGQSAAYSVVSSTGTSNELPVPVRQSGPGGSLEGAGAGARAGAAPEKKKGPQTFAEMGFVSKPVEEDSCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS4</accession>
    <name>A0A1E3INS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029776.1">
        <property type="nucleotide sequence ID" value="XM_019178338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS4"/>
    <dbReference type="GeneID" id="30195484"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129863" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48321" checksum="17DD025CEFB40615" modified="2017-01-18" version="1">MPFIPQRSLLSTMMAVLLFCSLPGGITALPFSDNSGHTAVQDRSSGDQPILPQTVVLNGLLLGAAKTKLQEGDADLQQDLDNLVKQAKKYLKKGPWTVTNNEMSVPNGTIHDYASQAPYYWPNNWETPESGEVCPYVKRDGYVNPEASLYTSKQDRADMFTASYSLALAWYYTDTPAYREHAAQVIKTWFLDEGTAMTPHLKHSQIIPCENDGRAIGILDFSEQYTTVLDAAAILSTVYDASWNSETEKAFKAWNQEFLTWLTDSKFGKKELSATNNHGTFARLQIAGIAAYVGQNDLAAAMVEGDKAIIDSQIGTDGSQPLELSRTRSWHYSCFNLVAHARLADIAHQVGVDLWGYKGEQGQSILGAIDFLTPYATTDGKTWPYKELSFIGYGASDLVNAAADQGDEMAKAALPSLTYPSAGNQWPLRPSVERLDKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INY8</accession>
    <name>A0A1E3INY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029780.1">
        <property type="nucleotide sequence ID" value="XM_019178342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INY8"/>
    <dbReference type="GeneID" id="30195488"/>
    <dbReference type="OrthoDB" id="10465724at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="37056" checksum="A49273F8077761EB" modified="2017-01-18" version="1">MSSFGTNPDTTSTPSDPTPSSAPATQSNDVTPSPLSSSPLPTSTTATATTTGPKHRHNEHTLPDGTRVIEDERTWGGEDGGGVSKVVIKRWERPAGSHAAGERGGGVGAGEGGVGSGGMEREHLLRDVRLNHINDALFSRFLQPPSDASEATDTRSKWPSEDFFSDAFFPLPMPSFGRLVFPEEEDPSLLPPHLSAPQAANNPKPHHTSSTTPSNPQIHSWSYASSGSLSGWGLVAGMVAVGAGVWGWRGRKRVKVLEQRVGDLTRGSQMSARANVVRPAQAAQATPGSAGSLAPNTSPTAAMGEIEALQKRVEELENALRSMGSLAGYGEKRQGGRVLDELRKGKDDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IR31</accession>
    <name>A0A1E3IR31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029693.1">
        <property type="nucleotide sequence ID" value="XM_019178255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IR31"/>
    <dbReference type="GeneID" id="30195401"/>
    <dbReference type="OrthoDB" id="2576413at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="31794" checksum="6E16BAC8458DF22F" modified="2017-01-18" version="1">MVDLGAPIGTHNASEYVQHEKAGFNHGVGGGHASGGIPTGTPIADKFGNNTTGTTGASTTADKLENALDSYGSHGTSGTRGAGVGSGKAVDGQYAGSGASDGLTGQSGAHTTGAGYSSSTSAGVPGGYPSGQTTSGSHGARDAALAGTAGGAAGGAGALAGDKYGSSKSGPTSGAAYGSDPTSQSGAYGSGAGVGPNSGSTGQYASTTSSNAGGVPGSTTSGSHSGLGKGAALGAGAGAAGGAGAGTLAGHGAGTGVGATGAGVGAGAGAGAGAASLTGSSGSGAGKYGRGTHNPSIGQPISDPKSLDTGGPHSLVWDAATGKYVHRRELTGGVGSTGEDVVKGAAKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRX1</accession>
    <name>A0A1E3IRX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029976.1">
        <property type="nucleotide sequence ID" value="XM_019177937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRX1"/>
    <dbReference type="GeneID" id="30195073"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137770" checksum="8BC6B4234215F3E8" modified="2017-01-18" version="1">MAGTRTVPDDLKVGALLPRGRSITGKVTTFQYHDTPNKPSCLLFTVETRSSHPPNPNGNGHPNKAHVIKHVIQLYPSKWHPYGEAPQSKRECSSVKKLLSNGYDELKAIGGEKEATVFMVGSLQVRSVLQTPREGASGTEWAVLLRGIGRMQIVKPGNRNGYIFKDDPTLPMERFNATEALHVPSRSPAISANASALQITSNPTVSTANASQALPTKRVSEWGIPSVKKVRTEQDGPAVSGPSRLGSTSTLPNPPPNVNTRPAGAPFPPVTYSVSMRPEGSTAAAASPLFELHPAEAEISERLQKAGLPGLREPIPQYTNLQNLVNGRMVNIIAYIHDCNVAKPGTSWDSNFTIHLLDATSKPHPDDPTERSFTSCTLFRPKVSQFDMFQRGTVLLLRNAIVQLQPDTRDIFKLKAASGDGNGKGAVVYKGEDEFVFEDKKLLAHVSEMEKERMKAMFEWGKRCLTPPSQKPVMGQAIQLKPDFATGPTTNGPSAYKSKKMRPLCDIKPGEYADATVKILRKEIDFKTTVEYYCTDGTEAQHGGFNRNYRGLLFNLPHNAVYVINVPNASEVGGFEHMEDGNVVTLENVHATRHRKDGSIVYTWEWKEAGAEDDPLRAKVAKLERGEVARAVERRIVALGGHVVVKEEPISTIENTGAGSTGSVEGEDSGTSDSSSSRVAAASAPIPVLSEYRRKRMKPLRDADVRDYIDATVEILHIDPISKELYVSDGTVADRPSGVPNRNYSNATFGLPHNAVYVFDIPDSHRAIWGASNLRIGNVVGLPNVNCRLHPSDASFAFSWEWREQAVRGRTIEAKSVELVTGNRAKIVKDRIAALREQHKLALGDGAQGDDEPFYRGGSKRKRRPLREIEVGDYVDATVQILDIDQGTFGEAVQLYVSDGTEADRAEISRNYFGKTFGLPHNAVYVIDVHDLQDVQGSGLIKAGSVVTLPNVHCKDGYRYSWEWKAQEVRGETYRAKSVMGVMEHEARNVLQRIASLKTGNQYPPAQNSAQNTADLSRTSIHQPSNAVAAATRYNDSSTHILPRDCSPAFHTLFRHPSEYPISSLRRIASTNSKINETPPRRTIAWAGKIYDQNEEGGSVCVWAWCKSCKRWIKNAESVLREQEKTVKAVGCRECGEGAVEWKYRFWVTLCEGDTELTVFCGHEAESYLPFLPPYNLSTNPNDTRRTLCRFTEIDAEVRDLIMGVPKLGSGKQQRDRPWIDWTVEPFRERNGRVSAWAVFGMTRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS07</accession>
    <name>A0A1E3IS07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019177984.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30195123"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57203" checksum="232A443F8E4CD273" modified="2017-01-18" version="1">MATHTAKRPRLAVLSPNTPRPGSDNTDDALFHKLPAALTAPATPSTSTVAFSSSPRRHNALASSSPTRHARFAPYSDASTCAPADHELTLQTGTSFIFGRHHVRNASVKKKSVSIESVIPRRLAHLVGNPENAVETITLPREAHHASRVHALVELVLPLSQNRDKILRVLVVGQNGMRIKAPRGMSPTPGKNGRKGVKLVQGQRFEVALARGQVVELNFGKVKVAVKMEGDVEPAYSSPVRAPRLSSALPSSLPPSSPPIVNVDLDDEVDVSPRERTSLESSPEPPLFPRSSPLPTTTTKPTFTLPSSRESSPLSPVSQRSNLSPAPEPSSPAQMSSPALPSSPYHDDYDSHEDNDELEGEGEGEGDAVDVKAERLEGLHAPSRKNSPSGLARASTTPVETRPPPADVDLPAIIASTVVFSGISKLSLPDLVRHMLESQGHLKDQGDEKQWTIWVEDVLEDNPMFGKVERSGKDSSGHPLLPHYFYNPSADPDAERAANFGNFARPLRKAARSAAAIDWRPVGARRRKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISE7</accession>
    <name>A0A1E3ISE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019178045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISE7"/>
    <dbReference type="GeneID" id="30195186"/>
    <dbReference type="OrthoDB" id="2574609at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="505" mass="55308" checksum="533CCC31539B0774" modified="2017-01-18" version="1">MVVKQSPSAPKQCRSDIIMSSTTSQVPFELPTPPAPILAPEHFDEPDHDLSPQLDNSISTTAPGSPTLAGVNSTIANMDLTRFTFSAKVYRLSFLNQSNDVLAISTSTPKAGKTGDMFKRKRGVIITRTLKMLEGGERAEVLTEKEKDELWVKIVGSEMEAQLLCRGDDDSDIKVEDVKMEVTEVEDEKNEGDENKGDADDVDEKSIVHHEAVAMKEKSLYSEYSEEEGDRKEISMLPNVPSPSRLVEQEASTDTVILLHGLLKPGSRVDSDQFFTPGGSSLPTSHSASLLNEYPSISEKPSTIGACSATDDYFSIRVPQRRQINSHLRVESNHQLYSPQLDDVESQHPPPRKESASKLPMMLFWFGFLLPLAWIVGGWFCSEAHTSRTTQSLESTSSDRVSSQATAPVSAPSPLQSPHYSRPLTPISNPGSPQSALHALPPSPPATVRSLPVADSTASSKSTYKVRWPGHQDKWAFACRMAVFVFMFVACVTGVAVPMALRADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISN9</accession>
    <name>A0A1E3ISN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029823.1">
        <property type="nucleotide sequence ID" value="XM_019178104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISN9"/>
    <dbReference type="GeneID" id="30195249"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="657" mass="74230" checksum="4DDFDB440F7B3959" modified="2017-01-18" version="1">MFTPLSKGSERAQDKLWDKSSPRRTRVRPSLPNVPAAATVQGQKSSDPSSRQAPWAILRGKPPPGGKNKGKGRGNSGLLGAPDPSAVSTGVGIGSSSAAVMGASSGSIGRSGGEMSGTVRRGLPYLTPTSPYSTPSGRTSSFPWYPTVSKTKSQSQITPSRRRPPRPRRISSVGQDEEDDTWASIFLNPSAKRVEGWMDTFWKRHFVLVILPCLAVWVWVAVPFPVSDPYKDNPFPDIPSWPKKPSDDGEDSGNDGETETRLPLDVNFYFFLFCMYLAAALLFITNLFSLYRLNWWPSKLGGKVSYALSWSITLAIGLAAHHLDFFYLRKRWDGRERDDVDWERKSNFLAMLLPAIACFSKLKRDKRHTYRHPIPAVYQTFFGQAFSRRFPASWNRFLWFMACLMIACFSVVAGQAYASLFLSTLPHTSLDAGTWVWSWVITVQILGQISIFILSAKVRSRALLFIYRLFFQLVYHVFYRNLFARLRSPQQFATVQMLSSISTIIIFPLQMSKPWHRMLQIVVGYPNPWEDHVESVAMGFFCRGLAQNVTMVGFLGWLAILHFGPNSQIYPFFRFHPTPEDPYTFALTFFASCAVWAFELVSSFIARQIMSFAWGVDVSQIGREEIKEYPELVPACGWASVHVSMNILLFLIKLNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU56</accession>
    <name>A0A1E3IU56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030236.1">
        <property type="nucleotide sequence ID" value="XM_019177852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU56"/>
    <dbReference type="GeneID" id="30194986"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="411"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="645" mass="71171" checksum="1DC786D1AF3C9785" modified="2017-01-18" version="1">MSRGGFRERPIIVISDSEDDLDEAFVLPKPKALSRKAGKYTIVPISKPDSKMPLSPRRTVVFAPSPAKPDSVGSKPNVTPAAKKPIAKFTKSPAPQKKAIVISDSEDEVDVESLGLDQLKTGDPDMIVGRSFGADTDDDLASAGDVLSSPTRRPSAKIPSLLTSSLPLTPTPVFGKSASSSVCESDSEEDWVPTRTPRRTPGKAKGLILSEDEEETEGLPMGRTVAKSKRPNASIFLDLAADVEDEEVEEGEDGYYDEDDSYGSLRDFIVDDSDANDYAEASSSDESEEEDFQSRSERKKSRQPPQDIEEVGDLPEDGENSGGTRGISWGDEDTNDFLRYSPPRRPVQVSDLNIKSLTIIDGTDSESDDPLPIHIPNRPKKTVKTKAKPPDIPSSKARAGMTKKGWNQEREKIASSLFKELDETVFQKKLGEKGAKVTIEWNSRLLKTAGMARQRRPVLKDGTFSTVYLIELSEKVLTDESRIKNTLAHEMCHLATWAISGDLKNPHGKHFKSWANAVMNVRGDIEVTTRHNYVIEYKYEWKCSNATCGAIYKRQSKSIDITKQVCGTCRSKLAPLFETSQKAASGFQLYLKENMKNAKAAMPSASHGDVMRALSARWTGAGKEATSDEHVKYWKDMAANRRFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVQ8</accession>
    <name>A0A1E3IVQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030331.1">
        <property type="nucleotide sequence ID" value="XM_019177580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVQ8"/>
    <dbReference type="GeneID" id="30194711"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="143" mass="16494" checksum="DC726F218CA94EA4" modified="2017-01-18" version="1">MVSLARTVRHFRQVGFREWFRQMTYIGDSKAGRLVGTDQFGNRYFENTDPAEEIPGRHRWIDYSQDDFNASQVPPEWHSWISHIRQHPPTEDAIMKASTPPWKAAFVENMTGTRGSFKTYSTTAPKVNAWEPVVKPRGSQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVY8</accession>
    <name>A0A1E3IVY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030349.1">
        <property type="nucleotide sequence ID" value="XM_019177598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVY8"/>
    <dbReference type="GeneID" id="30194729"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="37296" checksum="3D2D95825CBA985A" modified="2017-01-18" version="1">MGLLSGMDSLSIRGGSKGSRRTSNASAGSPAARARNDSETQIDDGDPNDTSTLDQEEGNILMSLISQLRPGMDLTKIALPTFVLEPRSLLERITDFFSHPELIFGAADEPEAKERFLRVMTFYLSGWHIKPKGVKKPYNPVLGEFFRCTYVYPDGSEGFYIAEQVSHHPPVSAFFYISPKNGLLVTGELKPKSKFLGNSAATIMEGEDRIRLLDRPEDGEYAISMPNTYARGILFGKMLLELCDLSTIANPTTDFHADVDFKAKGWISGGYNVISGKVNGPGRADSGEVGGHWSSAIEYTDKKSKEKRVLFDPAKSRSAPKRVLPESEQEEFESRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW00</accession>
    <name>A0A1E3IW00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030220.1">
        <property type="nucleotide sequence ID" value="XM_019177836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW00"/>
    <dbReference type="GeneID" id="30194970"/>
    <dbReference type="OrthoDB" id="10377710at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="49430" checksum="72C6225E15517A26" modified="2017-01-18" version="1">MVALNPLFDGAEADRVIGLSQSMKRASRFRNEEIIASTKLTVESFGQTTIPSHVFLTIPVTQEQLPVSWVDQNNPSSFVETTVELADWRQDHQGNSNLCRVERLSHLFPVLVPLGEVGASDAQEIQELWDRLQVLEPAQAPSFYPTAGHWVPDHDIGHIWTMGMPAAAAADRDLTWARGPLPSADELTVAFGSLSTHEEHDSLEPAIAGNSRPPSTQYMPPDEEEQPSADATFAHGPTGAAESAASGLIRGRVRASVARREALAEQEGTFGSYAPDEVQSWTFASPGTTERDDRSSRRRKLRLWLRKKVTGSDEFSEWAKKTRSSFQTTWDTAKTKTKAGLDYTTSAGTKSKTAMSNAWNSTKSTANSAWSKVSSVTSAAWKKVMSAYHWVVDGREKTTPAAKTTDTNAASADNKESKASEESKADVKSAEASTESDGGPKKPDNESKKDGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW41</accession>
    <name>A0A1E3IW41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030260.1">
        <property type="nucleotide sequence ID" value="XM_019177876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW41"/>
    <dbReference type="GeneID" id="30195010"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="540" mass="58016" checksum="D484191A35FF1F72" modified="2017-01-18" version="1">MSTATQAHVIVVPIAINGHLRPLLQLVLNLLQADPALHASLLVTPSVAAQVQRSLVQLTAFLGLESIDQLKEGYKAVVDRLQLVPCHTKSFEPSLSLDADSAKKGIQDFTDAMPGVLGALYDSSKTVEGFENKFGSIKPTSVIYDYLHFFVPEITRVVLGASNMTPPSLLAFIPTNSIGAYHALSSEDKGGAFARLDRLTREEIAKGSTPKEAYEKYTNVFDGKVITLPGLPPKFDFEYRPHTACIPSSPEALQNITKACTAVRDPSITGLILSGTDIGTEASDALAADLGNSLYLVGPQAPPQIWSGKSASKAATPDDAKVFKFLDDMKAKHGLKSVAYISLGSLFYPVLRPTIMRLILKGLREANIPVIFAHSSVVVPAPAELIKEFEGDEDVCVVKQAPQFSVLANEATRFIITHAGSTSVSEAILTQTPVVSLPFFFDQAEIAAQLEQAGVAIDLKQTKTFKDPAHNKLYDGTVIVGTEQAIKEELASVFEALKGAEYEKMVRKLGEIRADVEKEKNGGKAKAAMEALGKKLGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXY7</accession>
    <name>A0A1E3IXY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030585.1">
        <property type="nucleotide sequence ID" value="XM_019177432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXY7"/>
    <dbReference type="GeneID" id="30194558"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="273"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="47964" checksum="F582B53FA7ED6991" modified="2017-01-18" version="1">MAPSSPSGSSSSSLCYTNTLLAMPDGPIPAAHPDLTSHTSSFIGGYPTFPALPSAASNKTGSMPSDIKCGVCHKSIPLLAQVYCPPEDGENDRTMYVFACPKVGCQKREGSVRAWRASVRNEEYVRDVEEKRKIAEKAAEEERERARQNPFTLGSDGAQPAGSALFGSGQPLFGAAALNPFAAPSASTDPTSALSALSINEEEAAPIIAGPSKTFTPPLPAYHPVQYLSTIEEYIPPAEDDVSIASSDDDETPEQKAEWHEDGWEKILPKRTDEVFELFVGRLESAEDGKRQVLRYDLGGQPLPYSSQSPLTRKLFPGAEKPLGKNDELDLSALYTDKTIPACSRCGGKRVFELQVVPSLINILRPHTLTTTGSASEEVAPTAISEDERRKELAKLAAGIKEEGNKEQDGEMEWGNIIVYGCERDCVGVGEEWVGVEWESGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY71</accession>
    <name>A0A1E3IY71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05419</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030659.1">
        <property type="nucleotide sequence ID" value="XM_019177506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY71"/>
    <dbReference type="GeneID" id="30194632"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN93554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="44809" checksum="4BCC4395841DC1F8" modified="2017-01-18" version="1">MPMPMMQTPGPRPFTNPDAHLPIPSENYFPLTESSSADQGKTTWEDMAAQQAARKKKRLWIIAGVLLAVAAVAAIVIGVVVSQTNQSSDNDGSTNSGSNGTLTIGDDASVFEKDSRLHQSFWGFAYTPQSVLLPWCGAIQSNVTRDIQLLSQITSRIRLYGANCNQTAMVLQAIHDTKVNMTVWPAICKYPTAYDDQVTSLTDALKTYGTDHISGVTVGNEYILNTAGTDSTTSSTYLSAVSTITDKIAKVDSTIQGLGLDKVLPVGTSDAGSIMSKKLGEGVDYFMANVHPYFGSLAIDDAAAWTTSFFEEYDVDVAAEASNKPATYIAETGWPTGSDDEEDSNSGAGSPQGDASVANLQTFLDTFVCQANNNGTEYFYFEAFDEPWKAQVNTHISLPRPFLTKEMDRLELMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYH8</accession>
    <name>A0A1E3IYH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030388.1">
        <property type="nucleotide sequence ID" value="XM_019177637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYH8"/>
    <dbReference type="GeneID" id="30194768"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="388" mass="43041" checksum="76AF9BB0687D4FEB" modified="2017-01-18" version="1">MLLANTRHLASLLKPACTLRRGISSTSPTIHHVHQLTTFVASTAFKGSFPEKLAFAFDIDGVLKQGHHNVLPEAMRTMKLLTGEDGRLPKPIPFLLITNGGGIPDTDRLSLLSSELGITLTPDQLVQSHTPMRDYAKRYADKHVLVIGGKGDDCRRVAESYGMKNAHIPQDIIASAPSIWDRTELTQHEKAFARPQDFSKIPFSAVFVMHDTHDWGRDITLILDLLNSDNGYLGTRKEGRQNGEEAVELIMSNADVEWRSDWPIPRLGQGAFRIGLEAIYKETTGLKLPYTQYGKPFKATYDFSELSLRRYLASVGRKSDGDLNVYMVGDNPQSDIAGANAHGWSSILVRTGVFHDTHGEKPAHEPTVIADNVEKGVEWAIGREMGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J021</accession>
    <name>A0A1E3J021_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRaptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030761.1">
        <property type="nucleotide sequence ID" value="XM_019177180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194297"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1317" mass="145215" checksum="A9B84F0EA45172DC" modified="2017-01-18" version="1">MAIRDIGPYGWTVPSIKDPIGSMVTIMKQYTKQMKDLSKHSDLNCRTAPDPSKIVIQHHLTKARMAAGLNSYVAVIYNGHGIQEPPTEAGELWCYDKDFGECLQSGGPSEYIPILLFDMLTWAGASTCFVWDCPSAGRFIRAAHTEANEIDSQLRAAAAQNPSVAEVHPAIYTRRQIHFAACGAGGAVPRVKGMPDDLFTACLTTPLRIALLFHNLQTFPLTKSDSERSIRKSASYMEALWDNMSQKLKGRLWSELSAILHTIAWQTLEGVDYQKLFGKSGDVVNNLSSGFLLSQRVFAAYNATPESIPAIPSANSHALWTTWDLILDNFFEQLPRYFEDTRHAKDTNWEKEVKLVSFMADQLESITAADQDLLFTRAPKSGMIPGLTRLPIICEAAMTSEFRITACAALDACLRVLDVRDLAHAVQGGALDVAAKLLASDDVNIKPHVISIWSSLVRHDVCVLSLAQEGLESERLTTVPAVQFFLNALQEQLLMHEENEQSSTLDVAPIIQISAVLAAIANFVAGRSAPRFVLRTLNMSTVMLRTSIDIVRQWGALLVSEVLGCLDRPDDEELVANLKSDLLEMIDDGNAETRAAGVYALSRWLPVGESWSEDELEKALEFSVKLVAQNKVEGSPLVRRELAKVFVKILQSAKGYAAVALWTHILQEALRDRPADRTKVEDSILALGKKLKIDREDKQRLFRVTGIIKAICSQMFDPDPVVAKLVHQSLRGIILSLKAQSQQHKGAQKSEIWEDIYLAAFPSSGVDNGASWSGDMMNVILLSGDTVAELWEEQRQPSEDLSRPLHDSGERKKNGAKRSKVNHELFLRSKLALQAHVAQANRKAPGSSLDNARVKSSSQEDLSSMRHRELEDSLVIGEQQVGLPWKWTMRDITCPDPWSTVIFHSFNSTVMSCNKGHDLLFWDWSSSKKTGHVTLKLPDNEMITSARFVNELHEQNVILAEITNGDIHIFAGSQDSTRIKPIANFRALDMYSPRYMITADQNRRKIVTTWYRSSGKLCVGGASNVINVWDCPAERCSQVLNTESEVPVTSLITEPVSGRLLFSGQDDGMVKLYDLRQSSGKAVLYWKADATSHLTSDETTGFKSGAARGIAKMGVILGESKHVSSACYNGVLSVHDIRNLSQPAASVLAHPEGISSASFQPQSGLMSTISILGVSQEHGSQVKHDPEIVKQKPLSQKFQLATALSHLSVRPRSSSSTRTLPSVQPNSSASPTANWSLHRMALGSCEPVTSETMAFPVQSPDVQAQNYRPYTVMHPLRPFLGIGYGRNCHLRGCGVGEGDCTDSGSYTFLKSQAKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J033</accession>
    <name>A0A1E3J033_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030771.1">
        <property type="nucleotide sequence ID" value="XM_019177190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J033"/>
    <dbReference type="GeneID" id="30194308"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01407">
        <property type="entry name" value="SIR2-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="59389" checksum="DF6EBA821F21060D" modified="2017-01-18" version="1">MPSSLPLAHLLASTGPADFSARRQLSDVSTAIAKSKKVIVVSGAGISCSSGIPDFRSEGGLYSLVKEKYPDAFFTGKDLFSAGTFANPLTTAIFYTFIAELSRSCNQAKPTRTHRFIETLHDKKKLLRSYTQNVDGLERRMGLESGGRGRGLKKLGTKNVELHGDLGRVRCVLCFSDYEATSEYMEMFREGEAPECPSCSERCESRINRSARATAVGTLRPSIVLYDEPHPLGDDIGSLAAYDAARSPDVLLIMGTSLKVHGLKRLVKEFAKAVHGGKKPGLVVFVNATAPSKEWEGIIDVHIEGETDMWVERVEEEWRSIKPGDWLSQTLLDKENFSAKKPQPKGKKELSNRDINRLPTPPSSPTQSSFPTSSQDSCSAVSDIFGSQSSEALPSSEALPSSQASQATEVEDAVEAKSAPPTPLSPSKRRPKSQASPNKKSKGGIDDLADVLGTPNRKKLFQDDKAAPPPYTSADEDVFGTSPEKKTAVEGVQKSKATRTRGKGEGEKENVPVNTVKVRKTRAQVAASAALDRGVPSPRVTRRRAAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0M3</accession>
    <name>A0A1E3J0M3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030899.1">
        <property type="nucleotide sequence ID" value="XM_019177318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0M3"/>
    <dbReference type="GeneID" id="30194440"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="189" mass="21854" checksum="0329E3AE78BD00FF" modified="2017-01-18" version="1">MNKACHQILSAVFPETLPNLRGIKNHTPASRHASTSQLISRAIRDISDVRFINRLIAEDEEHYSDIVEALTMQYSTNAAALKFHDVLLPRRNIKEEFERSPWKLSFPSSSLRKPTLTLDLNQYTSTRGLALLSHFCVTESMEKELPVRYEVISYKGKTEIWPDFYDDAIDSMWAIGEGIYEKYIPRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1K4</accession>
    <name>A0A1E3J1K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030991.1">
        <property type="nucleotide sequence ID" value="XM_019176959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1K4"/>
    <dbReference type="GeneID" id="30194067"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="118"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="678" mass="72551" checksum="09C1BD6BAAF63704" modified="2017-01-18" version="1">MPSTSSFGIEDEEDTQFDSPEDEIAHYRDKYRQAIEMLSDTRAELEEFQQSSKELEDEMEQELSANDKQQADLREKIKRLEQEKDEWKNKHIALQKMHSSTTSAMQREMDNLRVAASSLLDMESRYNRAIEEKTLLEQDVATKDEMEAEAQRLKDEVRDANEEISILKDQLARAISTPPSSVSTASPTHEPIRKVSRSSLSEDSSSSPLPPPVPSKTDSTHGSPRPRMTRSGTLSSIPVPSPSTKRFSHIPQSPSTTSLSRSTTSRNLAAAAGTPLPNSPAGLTRSRSGIPQASPARVSVIASHQQTKSRGFKLLHDLQARLKATDDKLGGAKVPRRNVSGTGATVFGAVGAVGRRVTSTSSTATARSKQTDIAPATTLNRSQTTPLAQASALPRTGSVMSPGWVLVGEGDDTPTGPWSMTLPTDEPQSPLDPNFRSTSTTSSNRSLPMRPGIPSPLASGLARSSTTSGRLPSGRPPSRLAQSTTKRDLAARPMSPTHIPIASARQNSRPMSPSLIPTASSRPLSPEMWNRSESPALGFSALGQSTSASSSRLGSDSSSAPNIVARPPSRSGLNKRNPIGRGPPPTTTSRLHHHHSRGSLSAIPAASTGIEKVERAKRLGRPSSMGGEKRSAAGEKGSGAMAGRPNGARPSSVHTFNGTPPPVPRIPSSILRDKGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2U6</accession>
    <name>A0A1E3J2U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_04556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031149.1">
        <property type="nucleotide sequence ID" value="XM_019176674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2U6"/>
    <dbReference type="GeneID" id="30193769"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="15">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN95169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12635" checksum="854D30BF4ABEF362" modified="2017-01-18" version="1">MPPKSGKAELRACLVCSILQSTNDFLTQGCPNCEDILEMRGSSDRVAECTSLLYDGMIAMIEPTESWVARWQRIDKRMRGIYAVRVTGRAPPDVIEAIESRGGIYRPRDAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Z8</accession>
    <name>A0A1E3J2Z8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031202.1">
        <property type="nucleotide sequence ID" value="XM_019176727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Z8"/>
    <dbReference type="GeneID" id="30193823"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50515" checksum="831C2A0C7886D1F9" modified="2017-01-18" version="1">MLNNPVVETFGMVYHSCSHIGNAADILTCAIIVPILPYRLQDLGYSDISTLTSWILLAYSGGIVSCTLPVSYIFHRHPYRRWPLVGAVIGMLLAMVLFMLGKLYLMRYGSEHIYSRSLQYSGVDGGLLPHAPPIAGALYDRLGWNAPFISCIIVLSVDLLLRLFVLERSDIRKFHEKPLFLRPGTLKARLVDGRIVTSDDQGFKDVGFTELTKAEQDTLYGVELKPWEVLGASIKSPRGMTAFASIFVYGLIGGALQPTLTLRVQERWNRNSEFVGLIYLAAAAPTLIAGPIVGALSDKFGAEMIMLPCMILLLPWPPLLLLRNSLAELIVYSVFVNLFSTCAMNPSGLEATMVARNIQGVSEIHQFGAMEIAFGTLAGGQFYHKIPNHQGWTAVIWFIFGVSVVVMPMMFCLAGEPELTLAMRLFGRWDWNLGQGIEQREKRKNRHESFNEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J305</accession>
    <name>A0A1E3J305_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">L198_05198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030872.1">
        <property type="nucleotide sequence ID" value="XM_019177291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J305"/>
    <dbReference type="GeneID" id="30194411"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="245" mass="26479" checksum="DC20C7DABDE5C7E3" modified="2017-01-18" version="1">MAVRTQFENSTDIGVFSKLTNSYCLTALASSTNFYSVFESELSDVIPIIHTTIGGTRIIGRLTAGNRHGLLVPSTTTDQELQHLRNSLPPTVAIQRVEERLSALGNVIACNDYVALVHPDIDRETEEIIADTLKVEVFRQTIASNVLVGSYCSLSNQGGLVHPKTSRSELDELSSLLQVPLVAGTVNRGSEVIGAGLVVNDWCAFTGLDTTATEVSVIEATFRLQGQTSAAVINEMRDSLIDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J462</accession>
    <name>A0A1E3J462_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031030.1">
        <property type="nucleotide sequence ID" value="XM_019176998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J462"/>
    <dbReference type="GeneID" id="30194108"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="61923" checksum="6CF30C96516297D0" modified="2017-01-18" version="1">MASDKHSERAPSLMDDHAVAHLALPNDEATLFASPLPIVGERKTTTRKEVWSWYIYYVGNSGLGPFNFAISAWQNLLYQAGWDPAFPKGTVACGDGSCNLVAYGQERSVNSIVLITNGLSFAFQAVIFLLVGSFADYGVWRPHITTGFTVLAWAVSFAWLGVEKPSKWEAGTALYIMGLIGYQGALTFWTAAFPGLARDLPEIKESEEKLASGDTDQKTHDTLDMLARNRLANVSFLVCSLGELVVLAILAGILEGVINDDADSNTKALSIVCAYSAGVWIVCAIPWLIFEQYRPGNQLPPRTSYLTVGVKQIYHAFRLCLRLKQTFIYLAAYFFLGDCLNTLVTVIATLQNEVVSYDTKMLNYLLIDGIGAQAIGIGLFWLVQKKWTIPTKNMLLFNAFWILVLAAWGCIGITQTKFGFHNAWEFWAYQAFYGIAVCPWYAISQAMISEVVPRGKEFLFFALFSIIGKTSSFIGPFVSSAIIDDSGNTDMPFTFLLGLGVVSVGILACVDVEKSRRECRKYLEDEAIRVYGMDAEDIGVVREAVEMDGLRKEDDKSKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4B8</accession>
    <name>A0A1E3J4B8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031373.1">
        <property type="nucleotide sequence ID" value="XM_019176445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4B8"/>
    <dbReference type="GeneID" id="30193539"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="412" mass="44336" checksum="549BC113F2A7950B" modified="2017-01-18" version="1">MLSHVIYFLANHFLATTECGALAFDPALARGKGEEATSNELWDPAFFGSFMGPGAVRFSRNGVSLAEISVNARVLESWLVGIPSDTREYVRARLLAFNDSSNTLRNVKYAVAASYIALLSSSSAQYTTGMVEPPYELLGENTPDPMGNVGINLSRRGDRRRGEGKEAPYEAGQISQRMKDYAKGVTAVVDADAKWVEDALRTLRDVVVVDEAPLSDLWALGRHRLAVYGVCFVRSGAKKPCAHLALGDRLVRSALGSHHPGITLKSLNTPEQLSLWLFAVADLGRCIAERGRRTIFNFWSDHPSEASSSAEPPESSAWSSYLGLPDPLLILLAEIVNLAADLSSSSASIKEQAGELESAIRTWKAPGIRLTGAGAEGSGVGVGRVSVHRIGGLHPTLRHAQSDILSLLDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4P4</accession>
    <name>A0A1E3J4P4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031478.1">
        <property type="nucleotide sequence ID" value="XM_019176550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4P4"/>
    <dbReference type="GeneID" id="30193644"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="24471" checksum="BA7C1527EF19C033" modified="2017-01-18" version="1">MVYRPPTSPAPYRIGVLLGSNRHLSNTQGFSIYLTNLIAAHFPFLHPEVIHLEKSQGHPLPYVLSDEPPARHSRESLPGAYDNERVRQWSATVLAWDGLIILSPQYNSSYPAPLKNALDHLYHEWLNLPCAIMSLGGGGGGRLRRDLKVMCGGSFDMKVVEEGVEVAIPGNLIMGKKRIEGDEEFLKRYDEGAIAAVEALMGVIRRRKGVEEGDAIAAQMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4S7</accession>
    <name>A0A1E3J4S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031519.1">
        <property type="nucleotide sequence ID" value="XM_019176591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4S7"/>
    <dbReference type="GeneID" id="30193686"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="751" mass="79454" checksum="0BDF60C188B889F4" modified="2017-01-18" version="1">MNPVSPPSTRGMRDYIPDVPSDGEDYDAVLTEEEPIEGDFTPRAVIAGLGVGVVLCMTNIYFGLQTGWVSMMSLQSALLGFAVFRIPVLLPRLFPNMRPLTPQENVVLQTTAVATGTMPLAAGLVGIIPALGMLTEEIDGQGPVHMGWGSLVMWCLAVAFFGVFLAAPLRRQVIVKEKLVFPSGTATAQLISLLHQIPPPAEVQGTRSRAYRRLPRTSHSVSPARPRHEEEGAASFDDGRRSGAVRLEEEEKDKELMTGKGWWALGLSFLASGHLTVLSFLFPALFAIPVFDIVGLPFGAHLAANWMWWFTPSLSYVGQGIIMGLPVTLSMNFGMLVGWAVLSPLSKHLGWAPGPVSSTTDGARGWIASLSLLWVALAIMIAESIISLLPITISHASTLLRYYHQRTAHSNVFVSTPQSQTRRLSSEDDYYDPPSEDQNDDPEFEPPERLVPGSWVKWGLAVSALGGVGLVWVVFGSDGIKPWATALGLVLASVLSLIGVRALGETDLNPVSGIGKISQLLFAVLQPGNVVANIIAGGVAEAGAQQAGDLMQDLKTGHLLRASPRSQFYGQMIGSLASVFVATAGYKFYTSAYTIPGPEFAVPSAGIWLNLARLLNNGHLPLHVVPFMLALGAVFALISTVKAFRTSLPPSVSSSRLIAYLPSGIAFAVGFLNSPSFSIARLIGGYVAFRSAKLSGAGETPLLAIVVASGFVLGEGVVSVVTLGLTSAGFGAASCWGCGVGGGGYCSGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4U8</accession>
    <name>A0A1E3J4U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031539.1">
        <property type="nucleotide sequence ID" value="XM_019176611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4U8"/>
    <dbReference type="GeneID" id="30193706"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="461" mass="47846" checksum="988C4E98FB4215CF" modified="2017-01-18" version="1">MSPRAAYLTIFWACLKNLQVLFIADRNLADGFHLPELNFPEQSITCTSASTTLLPECLSITPSLYSLITALFTLGGLLGSSTSSNVVSQRGLKGGIALTGWLNLIGAGIMTFAPHWTILALGRLVAGTASGLGISLVPPFLSVIAKSEAELASKSGMVGTMNQLAIVLGICSGQVAGLLLTGEKGEVPGSWRYVTAISGAVAVAQILSAGIISSPTGEHKAPASPVDAESGPRDEAASPLLPGASSTPQTQLTLPQILSNPSLRGPSILCAAIMALQQLSGVNAVMFYSTPVLRPLLPTSVGVVGVGITVVNAIMTLPAIFLMDRLGRKTLILASIGGMATTSVLLAFGLNDHLQALSAISIIAFIASFSIGLGPVPFLLTSELVPQPAVAALSSLAISTNWVTAFLVALFFLPLRDLLSSPVDPRQPENGRKGEGRVFYVFTIVLLLGGVMILRGLKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6F0</accession>
    <name>A0A1E3J6F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor steA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031680.1">
        <property type="nucleotide sequence ID" value="XM_019176270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6F0"/>
    <dbReference type="GeneID" id="30193361"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="421" mass="46743" checksum="AE05A99FF274AD66" modified="2017-01-18" version="1">MTVVLTIHSKRYVFLTGHLQEPAYPTHNTHIIIKVFYWFSVPHDRLFLDALERDLKREKAGQEPTSVVVGEPASSFRYDPHRSLYEQFSRYILERNPKSRLVPTLQSATDALDTHADPRALDLCHVDVQHDAQVYFAPLGQQSIITSPSRDTMNTSRRHGIGHVIPMEPNVSVDPNSRLLGQRTSPVQTYETEPAPSHEALTVGSRIFDPYHHEKPPPSDQIFPLQASGPSSSFGHVYDTAFKLAQHVAHYHAVRHPSGPKRLVEPPSAVFQNNFPGRDSSTWVESSADDDTPPPSPEEEEPSTLAGPATVSAQMKCKVFIKQSHQQWKSLGPGKLRLYSQAKGNVKQLVVESDSASKQMLVSTIVLTDGVERVAKTGVAVEISNRGKRTGVVYMIQLRNEASAVGLFESLLVGSDRAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6P0</accession>
    <name>A0A1E3J6P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031764.1">
        <property type="nucleotide sequence ID" value="XM_019176354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6P0"/>
    <dbReference type="GeneID" id="30193446"/>
    <dbReference type="OrthoDB" id="2575374at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="953" mass="101674" checksum="C228126F480CA8FB" modified="2017-01-18" version="1">MPPRRPTTADSNKKLPAVPLDALGLDLHGRGPYAGTGTTGSGDENHRRSARQQASSNAESISPITTSSTRSASRYPYTNQSSSTLTSGTQNYSTTTLTVPGSPSMSVTSSQTSVFYSEGPETPVSKRRVVFQPQASPSLRSEQTSTPGRCAPPDRSAPPTPSSGSGNSGNSGPVPLAKKRSSSQLLMGIGKGIGRVGSVMRRNTAEGTSSHGSFSAPGSAPGSAASTPRKGVNNTGTWRKRGKMPSMQEQVVFEGTGWESMDRNEGDSGIGRPFNVEHDLHVSPDLQDLPPAWLSSLKAQGLSESDLFLISVARKRQHTTPNHHVAGDDFLRAPHSAPVGPSNEPYAYGTSDSQSSRASSATGMLRKFSFEVDRPAMPTAHGGRLAAGDVFGGHPTTNPKRISRRISSDSYPVSATESEISESEYSHHQHRLPTTAPHTTSPSSRSRSGSDPNLLAAPIPRQTKRLSAQLRGFKDLPIGDVESARDGEWTKSILGMGFAWEEPKKYEESTTAEKAVQSADSSGVGKALNRRSKLSLAPKQSRPCTPESLSKKIARKPLPKEEHTPPSSASGTAREFEPASVSTTTSFPRSPPPPKRPDNAHRRGDSGFFGSASAMSSSGSGSGGHHTNASVSSREVYLQGPQLKEVVVIREESGERAVAIPRTSSESFGVHYSSPFKSRSSVELDLITPSTSDGIPGLRAHGADDVEQVDTGYDVDYSSDDEEHDFESGFANQSGSAKKKRPKDKRQTFGLAPPPPGRDLPRLSIDRSPSLPQIGVSPLDVDASTFGKSPISPSPEPAVPGLPLSPPPSYSPLPLPKHLSAPHRNSTSSDSHGYPNRDSLQSTFSRYSRDSRTSLRSDRTSRTSHQSLKSWELGEVAHVRHVACKGMMPSYNVSSASLGDLMQNQAKRSPEIDRLGDTVVERLDEESEYGESEDGARDALDALGQAAQRIVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S6</accession>
    <name>A0A1E3J6S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031798.1">
        <property type="nucleotide sequence ID" value="XM_019176388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6S6"/>
    <dbReference type="GeneID" id="30193480"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="861"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN96552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="108119" checksum="4F6A3AB105F3820D" modified="2017-01-18" version="1">MSTPTALKDFPAPAPVSSTVPSAPAPAPAVPSAPPPPPSSSRPPRATSHRAPITINTAISAPSTRTHPLKRLSIDLSDQSYSHSTSTDAYTPITPTQENGHIGITRRRQSISSPRAKSNSVEIPQGKVRSPGASSGFSWLSGGRLGIPHTEDKASKSDDEREEDDIDTPNWKRQAKKGPIHHKWDWGMPTQMANPAVDVTPTTPLEGDQTTPLVQPINLASSSHSHSSAGSIPNPLLQPLPRDPNNILPLSVGSSPFASPVASRAPSPHRIQDFASMSSGGILPGPSSAPGPFTSVSGSSPRTSISTSSSRIFNGRSGSRSSAEDDELSPPYRKYNPHSWFARSQAPVSPKAPSNAPRIMRLPSTARLLPTGTRRWGWLLEWAGFGAPPDSPRISGARRSEREHLMDGGGMHRGKRGTKRVLGSKWIARVMVFIPTSLWSITLFLVALAIFAVTLTLTLKHILNPDKEALPWRQYCTSSYPTLYSLQDPSQKPISVSPDHASHSHPIPTNSFASSSTKLTLTPLTPSHPTWPYRPHASLPYSHETAQGELDSLLAPVGVLLGVFTTDAGLERRQMIRQSYGSHWRSRREGTEGVRVRFVMGRPRKMYEKAVHLEMEAFNDIVVLDIEENMNSGKTHAFFSWAAENATVPDWQYPHHPREEDIDDGESDAERERGGKANAPIWMGEKRPDYVAKADEDAFIMLGELEKRLRVAPRSKAFWGYLVKNQFMAGECYALTYDLVQYIAASTALKTLTRGKEDKLVAKWMNMHPQREEIVWVTDRCWIYDHPKAGTVYSHGFLYPSVVSEVRTENRTGLSPAVIAHRGGHDAADAYSTVSKFGVAYHPFADDMSVTEQVEALVEGSPLSRLREESHTSSKHSSQQTYSKTESTRHKVDRLYKAKSSRVERFLGDQDERGGTVVVHYIKKADWFVETMVALLGTADEQDVWHRGVGMGLSALERRKGRVAKPKSEGERKVQVGKSPKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z1</accession>
    <name>A0A1E3J8Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031931.1">
        <property type="nucleotide sequence ID" value="XM_019176018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z1"/>
    <dbReference type="GeneID" id="30193105"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="228"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="48511" checksum="E63D4DBE8E13E368" modified="2017-01-18" version="1">MRVISPPTSTPGQLPVDIQALVNQTISSLKDLVPPTASIVKDTIKDAIFQAIDAIDADMRELNLAIHENPELGFKEFKAHENLVASLNKLDFDVTNPSSLSTAFVASYTHGENGRVFGFNSEFDALPNVGHGKSYVSLIACGHNLIAVVGVAAAVGLKAALKACNIAGTVKLIGTPAEEGGGGKVILLREGIYDDLDACAMAHPGGGSGPPEYEGSCTVGGPGTLARAGFEIEFFGRGAHAGAAPWMGINALDAAVQGYTAVSMLRQQLEPTMRVHGIILGSEQWAQNIIPSYSKVSYSTRALDVKSCLELRDKVVACFKAAAEATGCTMEVKAEEDEVYADLRNNEPMAYSYQAFMENVIGQKITMGGMSTASTDFGNVCYKVPAIHPGFEIPCPLGSGNHTAGFTESAGKLEAHKLAMKVAKGLAAVGAKFLVDDSFADETKKAFERFKKGKGRKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J909</accession>
    <name>A0A1E3J909_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031960.1">
        <property type="nucleotide sequence ID" value="XM_019176047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J909"/>
    <dbReference type="GeneID" id="30193134"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1014" mass="109758" checksum="B81840383D9B6B0B" modified="2017-01-18" version="1">MRCPPLLQSVNLPSTPPLPAPLLSAAPPYNSPIPSAVSSAQRHPSANSDPSLGPLGSTGDAELADNTWVFNAFSSPPSPSTIASTTDSQIGGETFPPSSESTEEESSGSNHSRQNLSLSFSSLPSVFPQFQQYQSPTSLPSSGAPFTDSFSAHNSDFGQDYFHFPPDEPLSAGAEDSIQSQSPLIGGQQQQQQQQPHRLPASQPSSPARSIFPQQHQTPLGGRQRGATFSGGSFYSFGAANPLNFTFAQPLAPQQALPTHISLSSVQASNGSPSSPLAPSPDITTASPQYQGAQSQFLAPNSAQQHKTGENDIVMDDMSTPTPVHPRIVSAPVRRSSLGQYSQQALPQNLIAAQSFPQVQLPQNPSAGLTSSDMSSEMIDKLSLLDKILDSAQSAREALLRGQEVEVSHNLSDISTQLEVASELGVGPAHPSRDSTTPNSQSSQQSTSPNGYHQSPPVQAAAPAPAPQYHMPMMATSVPPQLHDMPMTVQPSNLLSSLVADQNQQGRRAPPIQTANHAMPSGTKMVTGDYLGKVQAPPLVHSHSYPNGHQLPSQLSGNIPPSTPVAPSPNFITSISAQHMPMISSPLATVPPSRPPSPPRYALPNQWEVEMMPIDMGVQHQVPAPAQQSAHPLERRPSTAERPDGRPIARGRSMSVNRNWNQNNGHNAMTSSVPPSAWQSRAGSPVDDDDEDSDDEGLRKTKRRRSSVGVDAQADITGGISDEVRKQLDQIFAEFLNSICCDLEMTDSKGEKIHQVLMPKKMQKLDESTDYRPFKFRIQAFTNAFADNLQQRGITEEIMSIKKIKNYLWRQNLISRFNPDGKKAKSKGNHIWNVDAKKLPGGGWVFRPFQRRIIGQPSNFALAGQRYEWEPRIWDPQAASETLRPTFSSPTGSLPSWLRWESGAKLVGVPDKPGPPFEIPVHAQFVDGGGQDATIDAVYPCQVVPQMTPMESSSQPVPMFQPMFNPIPPQSGFEYMGHQMPPQMNMASAPSQPELQFNNNNMVYPQPNGYSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J929</accession>
    <name>A0A1E3J929_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031944.1">
        <property type="nucleotide sequence ID" value="XM_019176031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J929"/>
    <dbReference type="GeneID" id="30193118"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="64820" checksum="3D35DC5CA3E6B4E6" modified="2017-01-18" version="1">MSDANKPSSNPSSGPSSAAASPLPASAVPAARSPAGQGDNDRGLMLPPPVPAKFGHSPSGSLSKAGPPRMARLPSLKQLSEHLKYHPSASSPTSQSPNPFEAVPVSSNSPAGAGPLRITTNPSALAGSNGAPMSGTSNSPIVAPSPSGRLKLPASAMMRSLSAGSNGGILPTINSPRTATGPEAGSPASSSPAPRTAASELAKSIPGGLGDFKEPASGSPVTHSRSPSLAGTGAEGSASMSRGVSKDGVHGYRDVPTLEEIRRRVSVSKGTGNQASGSGHRMGLPSMWMDPEEKTEEKQEEVKEVEKSKPTPVDAASTTPVDNAGKKKEHPLQHAWTLYYDSKTYKPDPSTLPQKQGDILADYEMTLLTVGKFETIEGFARHFNNIRLPSQLSPSSNYHMFKNGIRPMWEDPANANGGKWVVLFRSSPGTMDFAWANLTMALVGEMLDPEDQVCGIVASARPKIDRIQLWTRGRTDQEGLNKLGKRIVEVMALEGRDLESMSMEYQYNTSDSKPPAGAFLHIPFPIRNIGPPSTPSRSISTFQGPPGSAFGGGATPRSNLAPSSNLTHPLPLPPKSPSVHVTDSAPTMRRGLSGGVGNPFAGPLGLARSASHNTREGIAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J973</accession>
    <name>A0A1E3J973_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032012.1">
        <property type="nucleotide sequence ID" value="XM_019176099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J973"/>
    <dbReference type="GeneID" id="30193187"/>
    <dbReference type="OrthoDB" id="2575398at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="184" mass="21062" checksum="4B6FFB441A12871A" modified="2017-01-18" version="1">MITIAAREGVYDLEKQHGDLKKGWSDPTYMARACGRHELPEEPMARARWHWWGHEDGYVHRVVVGTTDCLGTTIDKEKKVMKEMSSAAARDEHFRKLMERVSAAKGRMAVEGEEIKARINREWAERKEMGHLLDKKLTRAEMRLLAKAEKRLANKMDKEGWASDTTAADSESEDEKPRGRGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B4</accession>
    <name>A0A1E3J9B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032052.1">
        <property type="nucleotide sequence ID" value="XM_019176139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9B4"/>
    <dbReference type="GeneID" id="30193227"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="37449" checksum="EB506FE13FD93D12" modified="2017-01-18" version="1">MSKVTPLRIVLSLAAPRPSLRRPTSFAQRLYSTPRSSAAAHAQSQATADLLNKGSTAGAGAGEQDHAGPFPLGVGAGGGSKPWRTWRELGLGGKLVRTVRQSGNLAVIIAGGTLFVVLTLALTTELFARNSPSVLYAAAVDMIRASDGLDQYLLPPIKFTHSPHSSSPVRGTPSISSTTVRNLSSGKEHLIISFWVHGRGKDEELSLGWLRRAWVSTKAYAKESVEALGLVGQEPEGLAKEAFKEDLIEEGRRLEAAGQKKSGRWFSWLGGLNLRAAASSVRITGREPDPAGTYTTGEARGEYVKDENGHYQLLSLIVDVPSSRAAYPGRAVIHQTPEAEVEGLLGKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBN2</accession>
    <name>A0A1E3JBN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032150.1">
        <property type="nucleotide sequence ID" value="XM_019175660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBN2"/>
    <dbReference type="GeneID" id="30192744"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21703" checksum="EAF720A551B71F1D" modified="2017-01-18" version="1">MSGEIRRKLVIVGDGACGKTCLLIVFSKGMFPEVYVPTVFENYVADVEVDGKKVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQGLPIVLVACKKDLREDPKTTQDLARMNQRPVSRAEGVAVAQKIGAQGYVECSAKTGEGVREVFQTATRHALQSKKGKSRSGKKGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBZ5</accession>
    <name>A0A1E3JBZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi apparatus membrane protein TVP15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032241.1">
        <property type="nucleotide sequence ID" value="XM_019175751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBZ5"/>
    <dbReference type="GeneID" id="30192836"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15887" checksum="ACEA3B5E63E0043F" modified="2017-01-18" version="1">MERFTQNPAELFRIVNIAVGGFAVAGGIGSLIKHHFSSIIIGIYEVLIGAVIIFLEVRPITEEHKALVHKYASFMHSFLGRGVFYLLLGVLMLNYYTILYVCGTVVGVVGAAYIALNFVPAVDAPSTMQAPSTDEEAQPVWQGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC88</accession>
    <name>A0A1E3JC88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CWC21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032157.1">
        <property type="nucleotide sequence ID" value="XM_019175667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC88"/>
    <dbReference type="GeneID" id="30192751"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="9">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="41336" checksum="40FD85CDB04482CC" modified="2017-01-18" version="1">MYGNVGLQTARGSGTNGYVTKNSAHLRIREGPPGGPFGGFNRDDDLHKAPIYRAPDQGILEHERKRRIEVKVMELRDGLEEAGKDEDEIDEECDKLRQRLNLVKEQNTGKGKSSHSMAAAKEVEMSRLGRALGVRKDHVEGEAFKIETPEEKAERLARREENERMRIEAALKREKEDEERKKAWEEKEKLRRREEYRRKQEALNPPKRGRSPSAPPRRRRSPSDSRSRSPVRRRRSPSYSRSPSPPPRRRARYSDSPPHGGADSRPPSPQLRGRRYSDSRSRSPVRRYDSRDDSRGRSYTRSLSPVGKRRRYASDSRSPSPPPRRGRAASEDSFKSRSERSLTPEVSRERVDNTRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEA8</accession>
    <name>A0A1E3JEA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032298.1">
        <property type="nucleotide sequence ID" value="XM_019175808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEA8"/>
    <dbReference type="GeneID" id="30192893"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013289166" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="163"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="415" mass="44763" checksum="1D7B74D13F098F56" modified="2017-01-18" version="1">MIAAAKLIDLLPALALLGMALTGLENAPTAALAVPQSREHHRHLAARLADNVAQQDKKRSAGAKRTLRRRSDGTICKAKNTESSTFTDVSSTASATASATASAADLQVAAVDTDSSSVADVSFTDSVSSTQAASSTASSNSAQSTDVTGSLATVGTGSTTKFGLAWPNGDWATSTSPDYVGNYVGTKTSWYYTWSPFSVGSADQLNVEYVPMYWGVKQQSDWWAQQSNWPSTVKNALFFNEPNQSGQCDISAGDAVQYWMNDYLPLRSSKGVRLGGAATTSAPSGLQWVQDFKTACVQYGNSEADCTSDFVPIHWYDVTIDGFKSYVESFHDGVGQNLWVTEYACQNFNGGAQCTDQEIWNLHTEMAAWFDQQDYIERYSPFGVMKDMQGVEQYNALMNPDGSITSLGAWYAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEU4</accession>
    <name>A0A1E3JEU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032480.1">
        <property type="nucleotide sequence ID" value="XM_019175377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEU4"/>
    <dbReference type="GeneID" id="30192458"/>
    <dbReference type="OrthoDB" id="2564790at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="879" mass="95072" checksum="8AC6EFBC4B1E1173" modified="2017-01-18" version="1">MDVRFPEPGELFCFSAISESRCQGLTGIQYVMAYIPSALGILLIPTLLTVAYTRPRSTLILLSIEVLLTIALSTWDFAVHIDAPKAQNIAVNDTAIAIISALPNLFSLLFCTSHIITDLRPLLPPVLRADTTTHGFVLLIAPLVPIAFVVELLSTFLLLDYAQQLRTSLVGFETSSDLGLHNILTWIAAGTSMGFIAFTILIGILILTNSKTRYSRKIKNITRWGERAILFGLLIAAVDIGLSLVPVVYPLIVARHAIQFVSRIFIAFGLLGIYRYEMGGWGEIGDSYTAFTDDKRRPASIASVSTFGTPPIYPLPTGQRPDMYVLPGKTGPPTKPQAGTYVLPGASFAARRKASQKRKGNKPRGAPSKLVIGGPIPGTFQRLAGGETRDFYMLNSAKFGGMAGAQAGGIGRGLAAAGTTGMMGAVSRLGMERVTLRTPAGRGPMLSIVSSTFSALEPITRTRSEQPAIEPGPGTAISSTALTVKKFTGSIYAPSAISVEASELHRWPPEGLVRLKGLEEEKERAFEGIDMEEKEIEGVGTGVLRASRMASEMDMVEKAWMAGDLARASPVVDDRDIQLRQTARFLTSESLTPTGQVDSPAPIARQLPTAGLIQEPLIPVKSYFTSKNPRASVMASVLSGHTRNGSGGSGTSLMANEAVRMPQPAMVTEREEVQQLAMRPRPPIPLAMRQPWIPQRQISDPLKAIRANARANSSSPILSETSPTLGTWEKNNRRTFASSISAYSNRSAVSPPAEADFNLFYAAPTETPDNSPPRDSALATAAAAAEIVNSDMSQYQKYSQTLRGSQVKSVMRLQKEAGLDEFDYDRLEESDSEDRQDKGWRMSLNSLDSEDLTPRAEAPSFAASQRKGRRPDREGGNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFD2</accession>
    <name>A0A1E3JFD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032462.1">
        <property type="nucleotide sequence ID" value="XM_019175359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFD2"/>
    <dbReference type="GeneID" id="30192440"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="680" mass="75350" checksum="E4E214BA640BA52B" modified="2017-01-18" version="1">MGKTEVAPGVHHVHPLPDSVPESEDLFAPPPRLRGEDNRPKPHIGPNYEAYLKEWAKTVGPNSDEWWAEKARTTLDWYEDFKTVRAGGFEEGDVQWFPEGTLNAAYNCVDRHFYANPDKAAIIYEADEPSESREITYRELMQETCRLANVLKSYGVKKGDAVSIYLPMTWQSAAAFLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKGIATKAIVDAALQQCPLVEHVVVLRRTGNKVPMTEGRDKWWDEECAKVPSYAPCERMASEDPLFILYTSGSTGKPKGVVHSTAGYLLGAHLSLKYVFDIHPDDRFACMADIGWITGHSYIIYGPLSNGITTTVFESTPVYPTAARYWDFVDKWKATQLYTAPTAIRLLRRMGEEHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFPGKQQCAIVDTYWMTETGSFAVAPIPGAISTKPGSATFPFFGMDLDIIDPTSGAVLEGNDVEGVLVAKKPWPSLARSVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYLWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKTTKEADLSRELAIQVRKVIGPFAAPKKIFLVSDLPKTRSGKIMRRVLRKIVAGEADQLGDLSSVADPEIVEEVKAKVAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFY2</accession>
    <name>A0A1E3JFY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032642.1">
        <property type="nucleotide sequence ID" value="XM_019175539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFY2"/>
    <dbReference type="GeneID" id="30192622"/>
    <dbReference type="OrthoDB" id="2587749at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1018" mass="109506" checksum="D702FB366FFD72E8" modified="2017-01-18" version="1">MGHTTIPPHLIALLSSPQTPTSYATDALEEWILHRRAKGDNLFETSVGLVELEDRTPPHLTYAFDRASYLTNVPHISDLSPPTGPFPLSRSASTSTILAHLLSSPPPTIQHSREVILEYTLARETKLREKKSGRAGKGTLGREAFEDIAKRMGEIEDGLRQNSSDSPRRGSVPLRDAYPSPRSSQGIPELSENQQIGLTLILSLRMSLSYFTLQELADQLLKLALGDAERMLVQHIRRRVPGEGRWGVGKELEFVEGLTLNRRPALRPAFRSAKARTLLPPKAVYPVSLPAPSKSQCIKHIQALVKEVETSGPDAAAASLQSHAPAGAAIGSPGFTVKRAMGSPTPAFSREGTPVTSLALPPVQFPTARRTESDPTIISNYVHEIISEFITREKRDYMLKSKWSKTGRAQLSKDLGDIESALCLASKNAASPLAPTLISTFLILRRTFFLPPSPLPQSIAEPYLDILPAPPDADDVAFREPTVSSTTAALYVNPRLDDERAYDVMEELVEFEKEKVEGAGGSEESMVGWAMEQLEAVQKRFPDGSYAATFARVKQSLVKPPSPVSSTSIAFAPSPTSSVHRRTRSHAFPDAQYSANTGSPVAVGVLKAQHTRSRSMPGRKGTYDEENEEEANASYQQPAQVPTPETQSAESSPPRVGSIVTELPQLPPLVITPLQMDARRASGVSTVPTSAGGSAGGGWWDVISAVGKEDRSGSPAPWDESSDKRSNGMTHSSSGYLSNPGSVGAPGLRESSSHGSLALGNRTNIEGPLPPGAEVARLPGAPAVPDFTRPMMSLDLNSPESSPKSISPPSKTDRGLYASQNEDVRASPGIPHALSSPPRVGHPSYDQDRERLPPPPPLRFDQPRGTTLGSSSNISSPSMSSATPTPTGMQAPRLSPAPFYPTSRGTSPVLAPTTATGPSPPAPSGSSIAFAHPPDVPKSSPSPPTPSTTPPVKASKLGTFGRTMSLARSKSKKEKAEKEKEKEKEREKEREKEKERVMNDPKRWNRSAVQNIMGPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHI1</accession>
    <name>A0A1E3JHI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032643.1">
        <property type="nucleotide sequence ID" value="XM_019175540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHI1"/>
    <dbReference type="GeneID" id="30192623"/>
    <dbReference type="OrthoDB" id="10333482at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="41474" checksum="FF6CC17744762F9C" modified="2017-01-18" version="1">MDSTRLPRPASHSSLRPPSTTIPSKLPAPTSSVPPAARLKRPTLSRQPTSAGLRSDGRITVPEPNVKAAIAGTAKETDVIKPGVATGASAQRRLIPSRSTLTLPKTSRLPSPSAICSPPRKPTLTHTKTAAVPLRPAASSNPLGPKRTVSSVASSLSLRSRVDTRKASDGKDVQKAAVRSLGRVGGLQWLRDANMGLSTPAATNSPSRIPSITTNTKTPPSTAATHAYPYTPTNPFFTLPTETPLLPRLRSAASHTSTTLGFTGEAAEDNLMDMDMSFADEDGLGDSLGEWKPERVPEYRRPKFTPRRATPPSTSHIRKCLAESKKELLGAKKERDELAGRVEELQKEKMKKSWRDVAQEGELELEEVRQAIKLIQRLRVEHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHK6</accession>
    <name>A0A1E3JHK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylcrotonyl-CoA carboxylase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032653.1">
        <property type="nucleotide sequence ID" value="XM_019175550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHK6"/>
    <dbReference type="GeneID" id="30192633"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="75"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="197"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="668"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="752" mass="81613" checksum="7E334C99675B6BDB" modified="2017-01-18" version="1">MGALTNSIARGILPASRRLQRSGVPLASLGGYTTTKIQSASLYPQYYTTGVAQPGIVIGGNDLRSEIPVSSAKQPFKKILIANRGEIACAIIRTARRLGVATVAVYSEADKDCIHVKMADEAYCIGPAASSESYASRLRMDKILEVARLTGAQAIHPGYGFLSESPIFAEQVRDAGLVFIGPPVEAIKSMGSKKESKDIMIGNRIPDRDSHTHRGYHGSDQSLDALLAGAQQTGYPLLIKPTHGGGGKGMRVVRDPDSFQDELLSAQREAKKSFGNDEVLLERWLERPRHVEVQVFGDQFGECVALRERDCSVQRRHQKIIEEAPAPGLSAELGRDFAEKAVAAAKAINYVGAGTVEFIMDAETGEYFFMEMNTRLQVEHPVTEMITGQDLIEWQLSVAAGNPLPLSQAQIPCLGHAFEARIYAERPESNFLPDAGRLLHARAPINTPHRLETGFREGDDISSHYDPMIAKLIVHGKDRPEALALLLSALKEYQIVGPSTNIDFLSSVAGHEKFASGPVETSFVPSHHDELFPPRVVPHEVLAQVALYLVLRDKAAQDAAGPWATLAHRRFGDVSTSSYSLDDVYVDLVASDVGYEVVIRDEQGQVYQQTVIGSLNTATDLQAQLGTTRFSSTIIPVPAVNRSERLHVFSSSSHYTITHHPSALDNPTGTDASSSSAIDNLVSPMPATVIEVKVEKGNVVQENQVLCVLESMKMEINVRAGRNGVVGEVRVVKGKGVEEGEVLIVLEPAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI34</accession>
    <name>A0A1E3JI34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032732.1">
        <property type="nucleotide sequence ID" value="XM_019175000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI34"/>
    <dbReference type="GeneID" id="30192072"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="327" mass="36554" checksum="472F81D01FA6F85F" modified="2017-01-18" version="1">MPPRPPNRNVSSPLRPAPNAPYHPPTDTTTYRDLLLFEERLKSNAEMLKRRRRRYMIFLWSFVAVLGCMGHKLVIHPPDNTLLLRALQASVAVVSITLVLFFASGMYEEKIRYAHSYINHSNRSLRPLNMHLNMRRPLPFPFSLPFFPSALRPTSANSARRPSSTPSPTSFKPSLPGKNLPSTLSPNATNKSRRPSVSPNVMATIPPSSNPRGELIFSSRVDRSFREGYERYRSAFERRREEKQRAARAERGWFWFLYGDTGLAGGGGRGVSPSPSVGSVSSGSSKRRSETPSPSGTTRTLTPIQGREHRRSLSPSSLGIELGLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI95</accession>
    <name>A0A1E3JI95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032782.1">
        <property type="nucleotide sequence ID" value="XM_019175050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI95"/>
    <dbReference type="GeneID" id="30192123"/>
    <dbReference type="OrthoDB" id="10436846at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22125" checksum="7389F750BFF1B6BA" modified="2017-01-18" version="1">MSQFTEQIWTVISNDEEENTNPSFACHPQSTRRARPISLTKHNLRSLGSISCLEDNTNTILLSASRYDPTTNTLSRTSLTAVRSDKRIPMTEFQVSVDAMSQVDGLLSRKLEEPGGEGDAWLVSCFQGENTKALLEKEEALFSELRDGDGGVSVVGEGRVQLVRAESPDAVKQLWEQALEFEKRESCYDEDSEASEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JII5</accession>
    <name>A0A1E3JII5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain fatty acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032825.1">
        <property type="nucleotide sequence ID" value="XM_019175093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JII5"/>
    <dbReference type="GeneID" id="30192167"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="83"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="504"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="618" mass="67921" checksum="3FB5F8F140A5B0DC" modified="2017-01-18" version="1">MSKKQLSITECHRLLSQPGSPLETEEKVIFGRRTKVWKNQAPHFREWILLNYEKHKNKIFVSAPLPRREPYPPLAEGDIGIDAREYWTFGEILDRGLKLAAWLRSRGIKLGDKVVIGGKNCAPWIVSYTAIHLLGAVPVCLNAWLPREQLVYLIKLVDSKLLLLDEDRARILSPYTRIAEFGLPPMYCWSDTTYLPSIIEVLSTPNPQGVQDILDGGGLEELGPESDGMIFFSSGTSGVPKAVLSTQRASLSSALSGMVGFARALLRAGLSIPTPEETAAEPQKAILLSVPLFHVTACLQWLSRSITFGNTLVVSDKWDIKEAVQLIQKEKITSIGGVPAIASQIMQSPDLPRDTTIDGVFYGGAPCSKGLASQISNRFPNADLSQGYGLTETNAIAVSIAGQDYLDRPESTGLPVFTSEVKIADPDTLKEVPVGQNGVILLRGVNVMKCYYNNEKATREAIDDEGWFNTGDVGCLDEEGFLYMKDRIKDLIIRGGENIASQDVENALTSHPHVNEVAAIALPHPILGETVGAALTLRATASETGKGGKVKVTEDDIIKHVRGKLAKHAVPVMVMIWKELDLPRNVNGKIVKREIRDIARQEWARRNGIKQIDEQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIN6</accession>
    <name>A0A1E3JIN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter, ACS family, pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032932.1">
        <property type="nucleotide sequence ID" value="XM_019175200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIN6"/>
    <dbReference type="GeneID" id="30192279"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="489" mass="55008" checksum="95D4038932D611FB" modified="2017-01-18" version="1">MSLSQTRTKLETFFWGKPPSDPKERKLLLKLDLVILSYVCLSYLDRANLANAYTTGMREDVGFQGNDYTYANSMFTAGYVVGQWPSALILSSGRISPRFWFPFCMIAWGLCTLGLAWVTTPHQVWGIRFVQALFEASTFSGTHYILGSWYKDHELGKRSAVFATAAQIGTLFSGVMQGGIMTNLDGKGGYKGWQYLFIIDFAITVPIATYGFVMFPGTPHGTKAFWLTQEERDLCLRRLPHVEQHKMTFGILGTSLKRLLTSWRWYLFTALFTVSATAFEKVGVYTEFNLWLESAGYNARQISYYPSIFTATAIVSTYFLTVLSDATRNRFMVNPVMFVAVFISSVMLLNWDHLTPGGHWFAYIIGGFGYAGQASNFAWANELCRDDDVLRSITLFTMNLGSNIWNLWYQIVAWPVVEAPRFRNGQIATLVCGAVSVLIAAAIVYCSKRWPPNLPETEIDHDRESVGGEADAKMRKDEEAGIAVEGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JQ10</accession>
    <name>A0A1E3JQ10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033254.1">
        <property type="nucleotide sequence ID" value="XM_019174875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JQ10"/>
    <dbReference type="GeneID" id="30191946"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16920" checksum="5C4B4B0E2D4FC81C" modified="2017-01-18" version="1">MRLLFYPALGEREVDELMPGIGSHTDFECFTILRQSFCDVPSALQVQNRQGEWIDAPYIPETFVVNIGDQFARWTNDIFVSTRHRVLPALAKDRYSIPFFFGCDHDVPLLPPDTCVTVERPARYPVVTAGAYVFDRLSKAYKVERSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JQ57</accession>
    <name>A0A1E3JQ57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_02783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033304.1">
        <property type="nucleotide sequence ID" value="XM_019174925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JQ57"/>
    <dbReference type="GeneID" id="30191996"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="586"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="664"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="931"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="931"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="999" mass="108851" checksum="DBD226BB82B2EC98" modified="2017-01-18" version="1">MSSAQDATASTSRQATVQRKRTNGSTNRDEKQFIGQWRIGRTIGKGSSGRVKIAKHAVTGKYAAIKIVPKGLILNSRMSMSEAGAKADKVLLGIEREIVIMKLIDHPNVLNLYDVWETSSELYLIMEYVPGGELFDYLVKRGRLPVSEALHYFQQIIHAVDYCHRFNVCHRDLKPENLLLDKDKNIKVADFGMAAWEAGDKMLETSCGSPHYASPEIVAGKAYHGSASDIWSCGIILFALLTGRLPFDDDNIRALLQKVKAGVFEMPDEIKDPARDLLRRMLEKDPERRITMSEILTHPFFVSRPPRPIPGRARVTPPTFDEVERPVNSPEEIDPDIMGNLKTLWAGAPDDQIVDALMCKEKTWEKVIYHLLIKYRNKHLENYNMEEEAYLEARERREARRQSGPSPARRKGTANQAQQPRLAPLGENESVANTPVKRPQAPTPNKASRAKSPMESPTPTKGVQQTRGPAGPRPPTNRGNSANSTASDAPTIIFQGATPTKEIPTAKVTSSRPTSEIIAPASPIINAPQVEDVNLQTFLNQIADQMNRFSVRSSVASQSSETSDAILGSDYQACLAFAAGITPNSAPPARAVAPDTQTEKIEEHGQFEDATDDQTDGDGVSIHSTFTASIAPPSPLAGLGLGAPSNRPSLHPVSGLNQQRWSYASSQGSSYRGSSAGSYQPMESPQFSYSPMELQTPAFQSDRSAPAPPPRATRPAPTPASRPLPLSPVAYEPVESLLHRDNSYVIIDNAELPSDASMSSWGSRSSGGFKARGGLDGFGMLKKNKKLTVDPTGYSSDNLGSPSATSSVNSPKRSWFNNLFNFKPATCSLLSHDNVATTRERVRRVLSSLGTRVAVVELDGHKALKCKLDEVREDGGNVTARGVRFRVEFSRASQTTGGQTNTLVTLTQEKGAESSFRVCFAELKHFMDSQPSAPASLSLGSRPAGQTRSYVPPTSPLLSAPPIRHPASAPTTPVVESHPRFGTPYLSLSPQPPTQLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR74</accession>
    <name>A0A1E3JR74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BET3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033415.1">
        <property type="nucleotide sequence ID" value="XM_019174363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR74"/>
    <dbReference type="GeneID" id="30191423"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO03364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="286" mass="31551" checksum="7775474586B0E756" modified="2017-01-18" version="1">MSASSRFSLSSLPSPSPSLYSHSHSPSASTLAAANQNRRESARASQPSSLQQQLFGSSTPAPLGPQNIQDRPLGKSKLAEVGLGAWSFLFAEVVAYSQSRVDSVSDLEARCVLLLLLYMMEPGVWLGCLRPVLIEGMHYRLSSLGYDAGQRILPLLLLRNTQSSGIKEPKREHRLIPILQFIHTQVYRYCFGKPADGLERSVEEENEYMITLNQPPLTQFISVPKDMSQLSCEAFTAGIVEGVLDGLEVPARVTAHTVPTDQFPQRTVILIKLDQKVMDREEALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR82</accession>
    <name>A0A1E3JR82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-dehydroquinate synthase</fullName>
                <shortName evidence="17">DHQS</shortName>
                <ecNumber evidence="17">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="17">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="17">EPSP synthase</shortName>
                <shortName evidence="17">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Shikimate kinase</fullName>
                <shortName evidence="17">SK</shortName>
                <ecNumber evidence="17">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="17">3-dehydroquinase</shortName>
                <ecNumber evidence="17">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="17">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_02236</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17 18">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17 18">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="17"/>
    <dbReference type="EC" id="2.5.1.19" evidence="17"/>
    <dbReference type="EC" id="2.7.1.71" evidence="17"/>
    <dbReference type="EC" id="4.2.1.10" evidence="17"/>
    <dbReference type="EC" id="1.1.1.25" evidence="17"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033440.1">
        <property type="nucleotide sequence ID" value="XM_019174388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191449"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
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            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
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            <position position="127"/>
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            <name>NAD(+)</name>
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            <position position="137"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
            <begin position="154"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="169"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
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    </feature>
    <feature type="binding site" evidence="17">
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        <location>
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            <position position="252"/>
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            <position position="337"/>
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            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022605"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
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        <source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
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        <source>
            <dbReference type="Pfam" id="PF00275"/>
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        <source>
            <dbReference type="Pfam" id="PF01761"/>
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        <source>
            <dbReference type="Pfam" id="PF08501"/>
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        <source>
            <dbReference type="Pfam" id="PF18317"/>
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        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODO03389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1582" mass="170307" checksum="BBF0DC8B182A95F2" modified="2017-01-18" version="1">MASSSADVLKISILGNESIHAGFHLFPYIFETITTTLPSSAYVLVTDTNLSSIYLNDIQKAFADASAKNGSNARFLVYEVAPGEGAKSRKVKGDIEDWMLDNNMRGVKVVQIPTTLLAMVDSSVGGKTAIDTPHGKNLVGAFWQPSYIFVDLAFLTTLPPREVSNGMAEVVKTAAIWKDDDFALLESRSAEISLAASARPTGPATAGRFEADRSHAQSLLLRVVTGSIYVKAHIVTIDERETGLRNLVNFGHTIGHAIEAVLTPAMLHGECVSVGIILEAEVARQLGVLSQVAVGRLTRCLQAYGLPISLSDRRITSLPASSQLSVDRLLDIMKIDKKNSGAAKKIVLLSRIGKTYEEKASVVADDVIRKVLCEAAIVKAGIPTRSPITMATPGSKSISNRALVLAALGTGTCRVRNLLHSDDTAVMMNALVELKGAVFSWEDGGDTIVVEGGGGILSAPAKGKELYLGNAGTASRFLTTVCAMVSGAASSEKSTVITGNARMKQRPIGPLVDALSANGAQIKYLETVGCLPLNIDTDGFRGGHIKLAASVSSQYVSSILLCAPYAAEQVTLELTGGQVISQPYIDMTIAMMIQFGVNVQRQKDAQGNLLDVYVIPKAAYVNPPHYSVESDASSATYPLAIAAITGTTCTIDNIGSSSLQGDARFAKEVLEPMGCVVVQTATSTKVTGPPVGELRALGNVDMEPMTDAFLTASVLAAVANKPCLPERRVEGLPETASRIYGIANQRVKECNRIKAMRDQLAKFGVETDEFEDGIIVLGKSHSSLLRGASIHCYDDHRVAMAFAVLACIIDKTIIEEKRCVEKTWPNFWDDLQNKIGVAVEGHELEVHNHASTSAKTLDHSQSDRPIFLIGMRGAGKTYLGRLAADVLGGEFTDADDAFFEESKLSVQDFVSANGWDAFRKLETEILGRFIQEKKGNHVIALGGGIVETEVARQILQAHVAKGGHVVHVTRALEDIQSYLDSIGNTASRPNWGEDFADVFKRREPWYVESSSHELYNVLEAVGGQTEEQHHQAMRAECHRFFQFITGRDSNRPRLGAENPTSFLSLTFPDITPALAHMAELTEGADAIELRVDLLSPSGQTPTTPTLPPASYVAKQLASLRCATSLPIVYSVRSKDQGGFAPSDQPEAYEKMVRLGLRSACEYVDVEVSWPTKVLKDITESKRESHILASWHDWTGKMEWDGQLVKSKYLLCIKYGDVAKIVGTAKSALDNSKLAIFAEEVRTQPGSKPLLAINMGAAGQLSRVLNPILTPITHAALPSRAAPGQLTAREVFEARSLVGLLPPKKFVLFGSPIIHSVSPILHNTGFASLRLPHNYTLHQSEAVDQGVLDVIRSPDFGGASVTIPLKLDVIPHLDSVSEDVKVIGAVNTIIPREGKLHGENTDWQAIRQAAAQNLAPSVLRDSSSAALVIGAGGTCRAAIYAVHKLGFRTIYLFNRTPGNAEKVKASFPESYNIVISTSLAALHTAPSVVVSTIPGDSLTLDPASTGIHFPQEVLSRESGVAIDLAYKPHKTALLQAAEKNAGWKAVPGVEILCLQGFKQFEEWTGKRAPEGKMRRTVMDKYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA2</accession>
    <name>A0A1E3JRA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033460.1">
        <property type="nucleotide sequence ID" value="XM_019174408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA2"/>
    <dbReference type="GeneID" id="30191469"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="33718" checksum="00915B0C79CE31DE" modified="2017-01-18" version="1">MAAKKTVVITGASGLLGRAVADKFIGQKDEVISLAHTRADRDPHYTKLDLMDKEAVEGFFGTHKVDVVVHCAAERRPDVAQADPEKAAKINVAVPAHLAELARQKGFQLIYISTDYVFNGRNAPYQVDAQPDPLQSYGQQKYQGEQAVLAVRPSGAKITVLRVPVLYGRTEYNAESAINILRDVVEDQSGKTYKMDARQVRTPTNVEDIARVLYDASHFEQPLPAILHYASPAPMLTKWDMTRIIAKHLNLPIDHITKDTTEPSGATPRPENTQLSNKALEELGIETREEASFEDWWAAYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH5</accession>
    <name>A0A1E3JRH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033515.1">
        <property type="nucleotide sequence ID" value="XM_019174463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH5"/>
    <dbReference type="GeneID" id="30191524"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="47807" checksum="739E2EF5CA91D87F" modified="2017-01-18" version="1">MTQTSSDLALASKTSRIVIVGGGGTMGSSTALHLVRRGFTDITIMDVYPIPSDNSAGNDMNKIAGADNIDSFGGTSDSAWDTWVKDPVFSPYAHSVGKLDLTENEGRASRLRAKYEKFVALGRKDFEWLENENDIKKWAPHLKDADIKASLYCATGGWLAARDAIDSVGRELQKAGVKTVFGPSGNFNSLVFDNDGKTVKGVKGKDGSVTEADLVVLAAGAWSPALVDLQGQCVSKCWVYAHIQLTPEEAAALKGIPTVYNDKYGFFFEPRVENNLLKLCNEFPGYTHYVQHQPFDADEPKRISVPRSHADFPSDTMPTEALDEIKRLVRIALPHLAERELINQAMCWCTDTADANWLLCEHPKWKGLVLATGDSGHTFKMLPIVGGQVADLIEGKLSEEKRHIWRWRPNAGDPNGTGRGGPPPKDLADLDGWRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRT1</accession>
    <name>A0A1E3JRT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033594.1">
        <property type="nucleotide sequence ID" value="XM_019174542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRT1"/>
    <dbReference type="GeneID" id="30191604"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO03543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="614" mass="69550" checksum="A603123EF6EEAE8D" modified="2017-01-18" version="1">MPGKARKGKSSHNNDPNQTSLKGWVIPKPSSAASQPSSSNLTHQPAQKNPKRVATSSLEVQDFTTKRSKSRGDEASINPPTHKTAPRHPTTSTQDDLHSNSNSDDISSDEDEDDCGSDDDGRSDELDDGFARCIEAEKMPSTSLPVTGDDFWMSYLITPLEQHASRLGLKPTPLPETTYKRLSEVLDFVLANKSVYFVWTINSMSKNVRKRLLGLLGLFMPTNFQELLAGPNPPSATQIYSLIDANGVWFNEYGVRVDKLEGRSEVQSRSVGAYWKVALPKGSVHHHPPLRILIYTGQTAKVSPSDNTMGFRLRWRQHVNDAYGHDEANKKDSLFTKAFIKSREEYRMAFTPIVTVPVPVGTKLDIPFRNAVKFFARLSEAVCHEACSTIYRVDPGCAHTPKTFWENSPREYTGMNARDPLRESFGFWELGKPQRPSPNCSTCGKLFGTKTQRDQHEVEVHGPNTFVCKHDGCVYRCSSEKRLETHRKSVHGKKEFACKIEGCERKYGTKKLLNMHRKEVHGEKVHACDECEREYGTEGRLNMHRKEVHGEKVHACDECEKKFRTNSLLNAHNKKVHQEKTVSCKEIGCRTMFRYESQARTHMKRCHPERKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRV0</accession>
    <name>A0A1E3JRV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033641.1">
        <property type="nucleotide sequence ID" value="XM_019174589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRV0"/>
    <dbReference type="GeneID" id="30191652"/>
    <dbReference type="OrthoDB" id="2576605at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="632" mass="67474" checksum="707F19F5E229353E" modified="2017-01-18" version="1">MVFSDAVKITIVVVAPVLFFTVLFAAAYLYRRYHSPYRHGTFRVEDGIWDPSKPEGLLPHCHMCYQNHSHGQDIDVSVEDGPSYESKAEGANNISELHYVEKSIDVRRLNHNPYAPDLITRVNSISSTLASKEPANTSSDVLPFGGGRRASHASAVDPNRLGYQGVEANALSHGVIAVGDRRPSVLSGGLSDRRESDTLSVRKVSFGGGEEMVNVQAAGIDQSKLPVRRSSNPSRSFSRRPSIKDGELQHDEQLEPVPFSHPFSATSLSSSTSLTRGGVGSASIVPPVPALQQPPPPRKNIQNRPGSLKLTSTSTRQSSHPPPSILASAYDPVTGVSTKALKSALITSPEMDEMSTGSDISEDFVEPTPGVFEAWKGFPQQGSPARAVLIQPLELTHASGQEPPAEPSLGPTSPKTLPPTPAPRPSQLIPASPKPSAPPIGLALPSSGVERRSSSSSNRSITYLADVVRDKAQRKGAMSAGLPGKERKNSLHVRAEEDGMEEVTINSPPPVPALVAIHQAQSLSSPTTPLKALVSASLSVPSPNVAIGRKASTHSAKSNTHLVVEMVRENSVRRKSATVVPASPAETRPQSVHVEIVSPNVYGEQDAPMLSPSKFQENLVEYENDSSRGQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTY9</accession>
    <name>A0A1E3JTY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033453.1">
        <property type="nucleotide sequence ID" value="XM_019174401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTY9"/>
    <dbReference type="GeneID" id="30191462"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101136" checksum="6F7317240D7B5F18" modified="2017-01-18" version="1">MSFLRRASLARKKQDDEASPSPQRAPSISGDSSPQAHNSSEASSIPDDSSITPSKNNHGSKRKSMFGGKGRKRLSSLFASSSTLSSYANDREGTSSPQPKSRLNNSTTSSSSTSVRSNVTGSVRSTTAGAPAEGGIEFPQRGLSNLRIGTVTGEVTESPEASPTVESGSAIGARDAATKRTRRDSMWSQWELEGVGEDGSSSDEDDGFLTPSEGLSEVEEEDEDEVEPDALIQSAHPAAIAAATTIVPTAPPSDFKVEPTNVDKGAVVTDTKDVSGTGASTIHRSLPTMTETRVRRHVSHRPDASTVDQSAVLAEDIETCRGAIKLFLTSHMKEAEDFCQEKAGEGHHLYLQSAMGIIEALKGMMTFDSVDLHNALDICKSTSITASTLRRANDSVMHRLGGLVKSGGGLARIKAMTPLERHAELVYAEQSLLKAMLAIVAGGDWIGLVREALNMRTAHGIYRSLQQYLEDADKHGYDDDIDMDFRSGVLLGTGTSSLMLSLLPGKVLKIAEVFGYAGDRTVALNTLMAVGGWTSGVAEPSLDETNEGLRRPICDMILLAYHLVISVLIPISGIDVPLARNVLAYNMKRYPDGVFFLYFQARLHTTQCQPAEANQSLQKALDLQLEYVQLQHMCLWDYACNHMMMGNFKGALDCFSILKDESNWSRAVYTYAAAACIVEMIEDGHKEASLEEADKLMRQISKLTKKIAGKSLPIEKFSSRKARKFESQGGRLFLPALELAYVFGSLGNTPRRSHLDVHIPRLNAMLSKLEVGEDEYGSKNGKEYWDDYVLGHFLRGMCHFIARWQPKDAVIPEKNVRPEDPSDEELDQAAEKDFKAVIRHGPDVQLDHWILFHCYYELGRLYAQRGNDELAKHQFEIVMSGKIPDHNPYMAKAAGKYSLEGALLLKTHAALSAVKEREKERSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW98</accession>
    <name>A0A1E3JW98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033725.1">
        <property type="nucleotide sequence ID" value="XM_019173918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW98"/>
    <dbReference type="GeneID" id="30190970"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="534"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="744" mass="80403" checksum="03B6560CE2540793" modified="2017-01-18" version="1">MAPLHRSFSLPTGNYVSRLKALSGQAAKDEVSNDKDQPSIQSLETPPSSFPGAPLHSAPLSDRRPALSSMRRASHHSHTPEPASAQDPGSAKQLVSPSSKKASPLLGSLKSWGKGSLRRRSVAVDVTVQEGKGLQLERTSSAQSNGTTCTAGTDRTDGTERRGRSRKAKSVIVHIPEKKEELTDTVPPPLPPNTYPPTSIPPPPLTPTHFDSQASDLLMGAINRGRPGSTTSSPNASSTDLRKSTSSTGGALAALGLRAAALGTANMAPPRSPEKAADSTPVATPAATLTPRASYLQASKPVGSGDRSSKNRAPSPFFRARRARDQARARDTSPEVGALKKDTNYPESEPESVAVTKKFRPQVSAYEDGDVDSNVSDDGVTEAETELDSEDDFSGTSDFDEEGILDEDGEVIFDEETEKNTEANAVFYEGDAGGLGGRSATDEIDDKPRDDSASQVLDYYGEEVEQDPLGEGPNVVVPPQSLFWTNPSSRQKKTSKGGLQMETSRPVFARDRCTITLTQGNPDGALEDSGKRMRRYVVLSDLSEESRYAVEWAIGTVARDGDEIFVISVKEDESKIDPKNWGNNDRAQKMRIQKERQTTALLLVKQVNSLLQRTRLQITVTCQFLHAKNSRHMLLDLIDFLEPTMVIVGSRGLGKLQGILLGSTSHYLVQKSSVPVMVARRRLLRPLRRTNPANLRHSPRVSLASASIEKAASSKQEDDVVDVAEEEGTTDEVVIAKEKKGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWB8</accession>
    <name>A0A1E3JWB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033745.1">
        <property type="nucleotide sequence ID" value="XM_019173938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190990"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="653"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="955"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1406"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1431"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1540" mass="168913" checksum="B8E6FA1443E2D94C" modified="2017-01-18" version="1">MPPSASTPRYPPYNASRPYNEYPQQYSPAGYPDPRYQDTPQSSIQRNYAPFDAYEPAGANSRAFPENASHPYYTNERPVFDPALQYGSGQYPYQSTSDARPSPSPAYAASPSKGPYQPVSTIPIASPSHPYQYQAQAQLSPYPIQVPSQSSSRNAWPSNPPYPHTLPSETAAPVNTIVNPAPQATIPSATPSIKIRFTAPQASSEPVMASGRSSRRASHTAQDSSALEPQIASSTGRLQRGSSRRAAVQVTYKEEEDEDEFDEALDEDANGEIDEDAFGEEEMPVLTTRSGRHHKAPVRLEEEFGQPPESASPEYGRRSSRTRGKRKIILDPDEDDEDEEVRPPPRNTFPPRATRNSLGGATVVEQPIQVVNGVSLRATRSSARAATRRHSSADGEDFEPEGDSPDDDASSDALGNYEDPDEDDFVEDDDEEGYGSKRRSSSRRRPAARSTRATTIPTRRSARSAAKARVITTDEDSPQKGRSLRARTSKVNYHIPTMEDISKEISMQEAIAAASRPSGRVGAGGGLRGMGVKFGLPFNLGGKGISQAMGDPDSSDSDDMEFASPLKSGAAGASIPGGGTAVAARGAGGPSDVPNFGRINPKSSTADADPLGVDMNVTFDNVGGLDNHINQLKEMVALPLLYPEVFQQFGITPPRGVLFHGPPGTGKTLLARALAASCSNGNTNISFFMRKGADVLSKWVGEAERQLRMLFEEARASQPSIIFFDEIDGLAPVRSSKQDQIHASLVSTLLALMDGMDGRGQVIVIGATNRPDAVDPALRRPGRFDREFYFPLPNREARKKIIGINTRKWTPPLSDDMLDRLAGMTKGYGGADLRALSTEAALNAIQRRYPQIYKTADRLELELGTIKVQAKDFMMSVKKIVPSSARSTASPAIPLPAHLHSLLSSPLERLKDAVDYVLPPKKHATALEEAEYEEEDEDSFEKHMMVQALSKLRTFRPRVLVHGQPGMGQTYLGPAVLNHLEGYHVQSLDLGTLMGDSTRSVENAIVQLFVEAKRHQPSVIFIPSISQWSQTIPELARSTFGALLNDIPPSDPILLLALADGSVDDLPGDVRAWFGFATENKIQLGLPAPAERKAYFADLVESVRRPPTDFPDGVPRKKRVFEVLPLAKPLPPRQPTEAEKAREEEKDQAARNMMVVSFTNLVQEFMKRYRKVAASVREDAMTYSRFLAEQAALAAAPVDGTATAPVDVDAAAPIDEQDAQPQVNGDHMEVDAVPAEADPTAIPSTADSALLAPPSLVPTARSTPAPEAVPAPVPAPPAAPTWQAHNIDVDTIQRRLVRHKYFQPSDFLADIAKIEENAFTLNDPERHAKMVEMGANARLHVSGFDSKWTPEFERYAERMQEKKRERQRRKEELEKEKAKEKEVESEVQGETGEAGPAEIESSSSKRPREEDDESNGREKRPRDDEPIIDEASTSSQPAVEPSTTTAPVPEPLPRAPTPPPSYPRFTVSSHALDLLQSELEAETNFLSIDQLEQLRATLFDKVWVDRKEWDRTETVEKMRKKLGEYVREVERWRERGGWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT9</accession>
    <name>A0A1E3JWT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033984.1">
        <property type="nucleotide sequence ID" value="XM_019174177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT9"/>
    <dbReference type="GeneID" id="30191235"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="28943" checksum="B2205420E5FE48F1" modified="2017-01-18" version="1">MNQTVPNLTQGGATNTTNGQDRSDPELYQVTSPESAKVAHAHNEYHGGGNMSRFITPGGSAVDNSQPAFPVFHRKFANPSPLGLLSFASSSLLLNLYQANARGVTTPNVILGMAIGVGGMGQTIAGILEWGCGNTFAATTFVSYGGFWWTLAWIYMPQFGIAASYAEDLEMLENALGLMMMTWGTLTFLFVIAAHRSSVALLCILVPLTITFYVTAAGYLMQSAYLLRVGGVIGCIMSMSGFYCALAGLLTPDTSYFMVPVGNLAPRQKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWU7</accession>
    <name>A0A1E3JWU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033994.1">
        <property type="nucleotide sequence ID" value="XM_019174187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWU7"/>
    <dbReference type="GeneID" id="30191245"/>
    <dbReference type="OrthoDB" id="2804493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="573" mass="61210" checksum="F000475B0EDF757D" modified="2017-01-18" version="1">MLPIVLLLAALAEARPQGENGGENGQIGGSRGSMTQHSMVSMPTESSSSDSSSSSDSSKDGVPTAVIVPVVVVIVLGTILSFVFKSRKWIAGKWNERFSSTRRSRSGTDAASRILTAEELSGSPSRTDVDNNAAGGADAGNGNRNRRGANGRPRRTRNGEYLRRTESGRSIRTLPVYSKEAGDEELVLVRQRSSSVMSDDTVTLEHETLVEENESFPTHNRTSSEETRPEPITEEAVELIAGAQPESPTPMPHSAPATTTQNPYRTSTPDASRHDSITRRGWGEAPSYLEAMSSPPFSSPNADLEAGTDNRPVPTLRTRTSSAFKDFLSRAGFSNQSRPMEMSQHPHSATALPLLQPVTSRISTQSSLHPGTSTYPSPWHSSHSLLISSPIPNTAMRASFDSTAIPRAGLSDDQMRFLSSNEAVNLVGVRMQDPPEGRKNKRRRGSEAVSVLALGGSGGREGQGQEEEEGVEGPPTWEQSEEHRRSLILSPTPGEGEGSGSGAIQAENTEQRGGASESERQEESPAQATVPRPSSPSTSSPALLPPAPVFEVEPPTPVAGQMTTQIPSPTIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZU6</accession>
    <name>A0A1E3JZU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034429.1">
        <property type="nucleotide sequence ID" value="XM_019173724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZU6"/>
    <dbReference type="GeneID" id="30190774"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="86"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="664"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="844" mass="94241" checksum="75700A1C295D3274" modified="2017-01-18" version="1">MPPPALSPVTGNPVPPYYIHSNTLHFQDTHGRSLLLRGVNLSGSVKHPNGQPSHKLEGFWETAEAGEGDFINRPLNLDDGSAEVHLARLRAWGYNMLRYVFTWESLEHEGPKKYDHAYMDYIIAVLRRCQEWGFRVFMDPHQDVWSRFNGGSGAPLWTVYACGIDPRNQTATAAAYLHSEWPSPEAPKPEEFPAMIWGTNYTHLANQTIWTLFFAGKTFAPKCIIDGKNIQDYLQDHYIDAVGELAKRIADNAPELYDRCIIGWDTMNEPGDGLIAYENLAVIPSDQQLKKGPTPTPIEGMQLGMGQALDVQTWNFGPIGPYRGKKEQIDPKGKKLWLSKEDEKTRGGGKWGWTRGEEWEMGTCIWAQHGVWDPATNTLLRPDYFKTLPSDPSHHVDFVADFWSLHWLAYSSRVRIHHPEAIHFIQAPVMKQPPKLPASFLGGRACSSPHFYDGLTLMTKHWNWFNADTIGVIRKKYWTVAQAVRVGEANIRKMMQGELSVLKEDTVEVLGKYPTLIGEIGIPYDMDDKQVYGYVNGGRGEGDFSSQQKAMDCSMNACDGPNNFNYTIWNYVPDNVHEWGDNWNGEDLSLWSPDNVEKRGYQDSPRPGTPLPTQGSSDFTASSATLAVSSSDNESLASRVNLQTGDIPPSLILSGARASAAFCRPFPVASVGTPERIEFDIASTKFTYSVRVRADDLANDQIYTELYIPFIHYAANLDSVGKGVNNVQTSSLDSTASTLTSRNTFKADLIEDERTVKNLDPSSISVRSVSPATAPLALQIDIKVSHGRTEIEGQTLKWFYPVPKSGEAVYTIEVERKGGALRKDKGYLQEGSWFDVCPGECVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K005</accession>
    <name>A0A1E3K005_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034485.1">
        <property type="nucleotide sequence ID" value="XM_019173780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K005"/>
    <dbReference type="GeneID" id="30190830"/>
    <dbReference type="OrthoDB" id="10585157at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17300" checksum="30A0881C0DD339AA" modified="2017-01-18" version="1">MPSSPSRMTHDHPVRDQRTSHAEGSSASRAYRPQETSPRARESPPNGDRSRRQSLVASPTQSDMSVKAAPRPSLTSVASRSSRVSEQKPTHSREDGKKSSKKPAYDDPDSDVESTAGVSRGKGRTGMDENERRRLEHRRMSMFQNDVEDAEKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1E1</accession>
    <name>A0A1E3K1E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01499</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034367.1">
        <property type="nucleotide sequence ID" value="XM_019173662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1E1"/>
    <dbReference type="GeneID" id="30190712"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="56"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="475" mass="52921" checksum="1625CAAAD05EB01A" modified="2017-01-18" version="1">MTFTDYPTFSNSPFFYDPRNPIVPETEEGHVRAHSNPTVAYYHPKNVGNYHYGERHPMRPHRLELTNQLVLSYGLHEKMSYHAPRAATEEELLDFHEADYVEFLKRVTPKNAQNLTKDWTKFNVGDDCPVFHDLFSFCKQYAGGSLAAARKLSSGSADIAINWSGGLHHAKKGEASGFCYVNDIVLGILELLRVHPRVLYIDIDIHHGDGVQEAFYLSNRVLTVSFHKYAADFFPNTGNLSEIGSDLGKYFCLNVPLQDGIDDESYISLFKAVMEPTITIFSPSAIVLQCGADSLGCDRLGTFNLSIAAHGECVRFIKSFGLPLLTLGGGGYRQSSVSRCWTYETGVLAGVQLSNDLPPSNYYEFFGPDYNLHPPLTGKIQNLNTPKSLERIRISIREKLRYLGGAPSVQMQEIPPDLQGLLADAEKNGGERMDERAEERREGKGKETDWLAREVGGSGDGMGSGRYFGGARRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2A2</accession>
    <name>A0A1E3K2A2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">L198_00883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034781.1">
        <property type="nucleotide sequence ID" value="XM_019173055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2A2"/>
    <dbReference type="GeneID" id="30190096"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="96"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="50648" checksum="FF4E8C5A31F5EF13" modified="2017-01-18" version="1">MSTTPSIEELKKWDQQDPFNWTRAEFEIPTIAACGGQGEGDSIYFCGNSLGLLNKNARKHMIEELDVWGTSSVTGHFNHPHNRPWKHVDRPLTPLLAKLIGAKEDEVAHTSTLTSNIHNLFTSFYRPTEKRWKIVIEKGSFPSDWYAIHSHPKLHDKVLSQAQIDDAIIGLEPREGEDVLRTEDILKVIEENKDTIAVVWLPLVQYYTGQLFDIAAISPKVHDIGALLGIDMAHGTGNVECKLDEWNVDFAVWCTYKYLNAGPAAIGGMFVREGLDDGGRRLAGWWGNDAATRFQMDPEFRATPGAKGYQHSCTPVFSSIPLLATLDLIDKVGFANMVEKGKKLTGTLEMLLKASPYYAKKDDPKGKLGFRIITPEAPFRGTQLSVVILPEEEHVMPKIFEKMLARGLVGDERQPSVIRLSPVVLYNTFEDVGRAVQIVEEAFKEYEKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2I4</accession>
    <name>A0A1E3K2I4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034683.1">
        <property type="nucleotide sequence ID" value="XM_019172957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2I4"/>
    <dbReference type="GeneID" id="30189998"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="15">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="485" mass="53058" checksum="1F30B66AC9C55B94" modified="2017-01-18" version="1">MSSACPFHTIPAAPSRSPLPDRATILAIKEQTNTFVLGTRKSNLALTQTGHVADDLRALHAGAGTRFGERQAGQTDGVDGEAEVPFVHPYSFSIESMTTVGDRNQTTPLHLLSPYSSTQPAKSLWTDELEARLTNGHFDLLVHSLKDVPTVLKDGCEIGCMVKRHDPRDALVVKAGLPYTRLEDMPDGSVIGTGSVRRVAQLKRAFPRLVFEDMRGNLNTRFNKLDNPENRFAALILAMSGLQRLDMGHRATSPLSSPTLMHAVGQGALAIEIRSNDPRVRNCLRGLGHWQTEWSCGAERGCLRVLEGGCSVPVGVESELEELDEDEIAANPELLEGVEDPFREQQDAPLHNQSPMLWFSGLVDTVSTPTPSTPAFSAHSLPPLRSRLAKLTLHSCVTSTDGTKHVLFTPPPVLVRSYQQAEKFGEDCARQLRAMGAGEILDEINLLRKERELRDLESAIERSRAAEEESEKMGLTQNGTAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2T4</accession>
    <name>A0A1E3K2T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034965.1">
        <property type="nucleotide sequence ID" value="XM_019173239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2T4"/>
    <dbReference type="GeneID" id="30190280"/>
    <dbReference type="OrthoDB" id="2565330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="449" mass="47666" checksum="1EB24BA5C1997802" modified="2017-01-18" version="1">MSTYHPHTLNIFDYYQTARVSSAAVASSSTSRPIPSSADPATSTHNDEAAYTGAASSATDYGPKTSASIDGSVANSTVTSVTTSSTPSTRRPPLTIGAAVAIAVVSSLVVVGSIILIVLYTRRRRRMNKMPGNVAVPKRKKEKGGGRPLERIETPVPKAVAQLRSERSLLPQPSPPRMSQRETIGVVLPTHPRPAAYPIPSYQSPFLDPPRSSLTPATSRHRSESTYTDDSEFDMLAQDGSSYARTLSTYSEGVNSEYSERDLGTFVPMTSSSAHGHFSDTIAMSARPTLAVDTKSASGPSDEGTWAYTAVDSSSAGGSGPGSGTSGWNPLLTATTPYSSTTRTLVSPFADPPSLPQPNTGSGSFMGPYLNHPSPSVVSDRSWRTEDDALLIARGAALDRERSVREGGLRRGTTIVRHLDGGSVPGREEEAQDDEEVHLPPAYGELYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5D1</accession>
    <name>A0A1E3K5D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035271.1">
        <property type="nucleotide sequence ID" value="XM_019172329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5D1"/>
    <dbReference type="GeneID" id="30189359"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="370"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="964"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="987"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117623" checksum="0808F3A4AC8DE55F" modified="2017-01-18" version="1">MNTNQLGSMFSTRLSSAYNQLRGDLGAPQTATETIEKLVDRIQTSAAVEDRRTAVLGLKGLSRDWKEDVGHNALPSLIAVLEHDAPFDVEIAKATLETLMQLCETAEKPAKDDLGLFFTDAFLEDPKPAHTLINLISSSSSFYPRFFSIQFLSQLLASRSQVAQSYIMSAPPPGIDGILAVLDTSTGPTMAGGASEMLRNEALLLFPAMLSGNQDLQKIVAFSGAFEKLFQIIDSEGGVDGGIVVQDALAAVGYLLRFNVSNQNYFRELTLIPQIPHILGFPSPLAKDEATPEEFALQYWPEQKVDNTSLVLGLVRMLVGGPGGGNQNAMAASGVTRCLLELSLASNAPASIKSQCLSTLTPILTSSPINQDLFASLQVSHLLAVPADEVNPNGGFVRVPPKPAVVALVESVVEGDPSSGGRSLRSRSAGVNMFQAYLSGNDDARIGLLSSLLDPTADGQSQDQPSASSLILTGLLELPHASLSPDFDPYPPLFSCLLLSHLIRNSEHAKKLARDVTFPSGDSDSAVDTDDDKVSLIQLVVGNLLLASREQTECVNKAAKEGASDGLKEEEEWTRVIVGYLMLLCTWLWDSPKSVKEFLSESNNLQALIQPITQNTSIDPLIQGLSAFLLGVCYEFNREPGEITRATLHPILHSRIGPDQFVSRMARLREDVRFRAVQPLDFELDEQVAQQQSHQGEEEADEDVEVWFDWAFVDFWKNHYYTIQRSIAIDPDAVRGSNTPDDTETTAIILSLRSKLKTQTDEVASLTSKLDSIHAEHKTSQDALTQQTFELGEQVKTLTAQLEESKALVEALESELAGLREAFAKSEETAAGAETTSKELGNVKEEFEKVKADYEKASSELQLARMSAKGRETKMKDLEGKVKKLEEEVAVAKASPAPATAPSDPAADTGKQAEAEEALKKKEEEIAKREEEWKLKEAEYQEKLKQEEVRVKELEESAKASAEKTTAGEDKTATLESKIKELEEKLAAAPAAAAAAEPAQGGSNKQAKKRAAELDGKVKELETSLAEEKTRREEEAKEHEDLLVLLDELTGKRMRDKEVMKEKGIEVSEDEEEGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5V8</accession>
    <name>A0A1E3K5V8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S small subunit ribosomal protein S19e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035079.1">
        <property type="nucleotide sequence ID" value="XM_019173353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5V8"/>
    <dbReference type="GeneID" id="30190396"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="18065" checksum="D31CBDF295B337F9" modified="2017-01-18" version="1">MPGVRDISADAFITAYSSHLKRSGKLEIPTWVDIVKTGPQKELAPYDPDWFYVRAAAVARHIYLRKSVGVGALAKLHGSKNRRGVRPSHHRDSATGVERTVVQSLEKIGVLEAAPAGGRKISQDGMRDLDRIATAVLEAEREEEEEEEEEEEEDEEEEADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K610</accession>
    <name>A0A1E3K610_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">RNA lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035312.1">
        <property type="nucleotide sequence ID" value="XM_019172370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K610"/>
    <dbReference type="GeneID" id="30189400"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="461"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="272"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="69365" checksum="BCFF2824B72EC7CD" modified="2017-01-18" version="1">MRIAIQGCSHGSLAEIYDTVEQYTTTTGNQIDLLLLCGDFQALRSVHDFPSLAVPDKFKQLGTFQQYYSGQRVAPVLTIVIGGNHEASNYMWELYHGGWLAPSIYYMGAAGSVYVNGLRIVGASGIYKSFDYTKGKCHHERVPYDSKSLRTIYHIREYDVEKLMRLTPSPNTIVMSHDWPTTIAHHGDKQALLRRKPFFAEEASTSILLGSPPLLKLMNHFQPAYWFAAHLHVKFAALYQHNFPSHSQDLIAQNQSVHNPDEILIEDEEPLVETGKAGNPDEIKIDDDEDMGDGAKGNPDEIVMDDGEFEDLPATGGGVKERGNPDEILVDDDEFDTPTAAPQGVSQTPAGENPDEIVLDDEIDDPPSPAAPTNDSIPAPAPAAHTAAPVPVPASEPTQPSTTLMEPIDESADLLAAARAKGDGSTATGTIAPSPDDAIAERLRKEAEEEKKRWSELAKNAPGGQGVPGSTKFLALDKCGPNKRHMQFIEIPDLEPNPSYPPRLTYDPEWLAITRALHPYLPLEYHAIRPPPSHILGQMIEDERIRMREEGLLVPQIPKEGEEEGEELVWEKGKIDVGRVQRFWWTAPPQGEPGGSATAWYTNPQTLSFCGMLGLDNKINPAPPVPLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J8</accession>
    <name>A0A1E3K6J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035669.1">
        <property type="nucleotide sequence ID" value="XM_019172727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J8"/>
    <dbReference type="GeneID" id="30189760"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="71" mass="7706" checksum="92260D4EB9E4845B" modified="2017-01-18" version="1">MASSPDDARLQNARETIDSLHDLSQLLQTGLDKNTLSICVGMIEQGANPDTLAAVVRELRKEKEALDAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Y8</accession>
    <name>A0A1E3K6Y8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase regulation protein NCA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035479.1">
        <property type="nucleotide sequence ID" value="XM_019172537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Y8"/>
    <dbReference type="GeneID" id="30189569"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66911" checksum="991104E3FFA9C8B9" modified="2017-01-18" version="1">MGLLTAHGPSYAEEQLTAQLANIATLPVHLPPTAQRFSASAQPSHHIQTALSDLSDPKQLTSQKLVQVLEGLVESREQQVHTQEQTSELDELFEKEVVGRAVTVLWKEILDEFVQGALKLENERAWWDSVLNSRRGVSYYLIQTMPHRLWSAIPPRSQFTLSAIRDIRFPSKDLLFKPLQSTTSAALTSITSPWTLTRREILSSRTELTQARDRAAHKIGVLASQGPRWGQEQEGVQAFGDVGSETQRIYTALCSILDVPLPKPRKSRSATPPQSIATPTTLLALLKTHLPSSKAVLERTVTKNGRPGSLTRLWFPLLFLPPTLYIVVTSIARNKEWMKEQVQNGKETVKGFFVQWVWEPLEGIGKTLRGGGEGLGVAPTTVKSDQESLERMVLDLGKDYYHLSGPALEALGEKVKTGNMEEVLRVYEKELQSPVKNALMGSLIRTLLIQVQKTKTDLSLSLLSLDHLLRSQQLTFAFVGLAPSLLVLYATGGWLQGIWKGEKRGKGRRRQYWSSLRDIERLLITAPHHQSEMSPLGQGLLIVGVSNLRDWAKGMAGGKREAFMDDLRMLENPSLGRGDKLRVVERIWRCWGVDGRGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K737</accession>
    <name>A0A1E3K737_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035754.1">
        <property type="nucleotide sequence ID" value="XM_019172812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K737"/>
    <dbReference type="GeneID" id="30189851"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="503" mass="55723" checksum="19A8CEED2D37A002" modified="2017-01-18" version="1">MPPRVSPSPSPSRPRESPIEVLYNTAVQSFVRRDHLKTQASLSRLLELLRAKRQGPRQVWYQLDQEDEDDEWEEKVANDEWMIKTLKLVISSTVNLYNDPPRKTQSLPQVLVTLLPPKSPKEVLSYLQQRCLTSYYGTIAPPVPLLPPPLVSTLTLACLKLVPLKPSLDFAHGLCENWLAALPNSFIDFITPSPTSRRPMHKTGSTSAALEHKRLDGARERYTKVIELFVGEVLCREGEWEMAKAFLEGEGVLSSNRKEVLYKHLRKMQTKQTPPLPAPSPSSSLVLPSSDPTPDLQLPGSAKGKNRRRTGSTSSASSSSSEATARPGTLQRGLTAGTPLSKRLDKLKKDGERDAASDGSGFSRLSESTFKPSLPGTPIPAGHPVSVAGLSGVLIRVIGSLPIPQSILGRLLALSDSSPYLMSLPLPLILFLLIFLRFRRTHRSRPPASQSTISLGSRSQVQARLAQIRAGQRGWLEWAWWYLKWWVAKFGGVWKLGTTITYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K746</accession>
    <name>A0A1E3K746_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA clamp loader</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035538.1">
        <property type="nucleotide sequence ID" value="XM_019172596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K746"/>
    <dbReference type="GeneID" id="30189629"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003200">
        <property type="entry name" value="DNA clamp loader, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="356"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="775" mass="82174" checksum="E66EAC9280CC77BD" modified="2017-01-18" version="1">MPSPKRTRSEDGSTPSSTPSTPSSSRSHTRAAAPVENIPVTPSTAPSARLSSRRQILTRSQSTTTNLSDLARPPRRTTLLGPTSSLPNMGSPSNPFTTGTNFAMTPPTTRTRSSGTSMLLRTQSTPSLTSAGSSSLKSLAGAPAGESEKPEKDGLGESRRFGKGKENIPPKRAEQNDEDEGPRKRIRMTSMSSFTGASGRGRSGSVASIRSESTNNGRHASLAPSTSSMASWGRASSPTPSDASFSTTIPDLPTPTQSFDRLTFDSDPLETPTKSRATRAHGLLTPPPSSPSIMDVDPFELSAGPRFTKEVGAYKQLKAALRLSAISGSSLDDTIIGRDEEKSIISAYLDNTDSTTDVGMYVSGPPGTGKTASVTAFGRQRVAQGWKVVELGCMGLKVGDVWKRLGEEFGCGKSEKDVVEYMKSEATPTFIILDEVDSLMPPPPSKAPPAVSHLLAKLFSLPYSNPLVKLIAISNTLDLTIRARLVLPNNLQPSVLPFKAYGSTDMSNIVNTRIAAAAVEGVKVDNMTITLLGKKVEAQNGDLRMCLGVLGSAISLAEAEYVKKLSHNPDPSKPVVMTKVAITHMMKALASYTEKLRASAGSAVGGKASETGKKVKSVQLQGKMVLMSMLVYLIRVKAGLHGCPSMKAASAPASADPEIPAPVLYATYSYLLSHNTSPFSPAAQSDYLDLLTHLESLGLISQTATSGRGGAAGNMVKIVLCVREEEVREGLGLGEGQEKGIAEEEVQKVWEREEGRVRRVREKAAKAAKAGQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7E5</accession>
    <name>A0A1E3K7E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035314.1">
        <property type="nucleotide sequence ID" value="XM_019172372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7E5"/>
    <dbReference type="GeneID" id="30189402"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="468" mass="50772" checksum="540453B796E2A717" modified="2017-01-18" version="1">MAKLKNFVLQVDDTSSSLNAGLPLAKGMSLSHWQQTTRSHPLLNERTTRVLPAEADIVVIGSGLSGALTALSLLRSDTPPASIVMLEARELCSGATGKNAGHCKPDAYRGYSEYEERFGAKEAIKILANEKRTWQAMVAFVKDNEVDCDLWTGKTMDVFMDEESTTKAASVFQAFQEAGGDVSAIEVTSERSKARKVSRLEDARAVYAWDASTLHPWKLVAHIIQQCLKAGLNLQTWTPVLSITESSHGWTVNTDQGSINTPTVIHATNGFACALLPEMTSLIDPTPHMCNRIYPSSSFSGTNALHNSYGVIYANGMYSVNPRSISDGVILVGGSPPSLHELEEYVAKDKKRQTDDSLVNFEPVTTSVRELGSKGFRWESSDYGAATQYDCSWSGILGMSADSVPFVGAVPGKPGQWMSCGHNGHGMARIFTCAPALAKLVQGRSWSETGLPGCFQVTEERLRGLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7V0</accession>
    <name>A0A1E3K7V0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-processing factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035788.1">
        <property type="nucleotide sequence ID" value="XM_019172846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7V0"/>
    <dbReference type="GeneID" id="30189885"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000774">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="945" mass="104745" checksum="574E608BA0631391" modified="2017-01-18" version="1">MSNLGTVKHIPKEVRYNFLNMAAPASYVAGLGRGASGFTTRSDIGPARAGPSADVVSEAQARRGEEDIPDPDAMQDPDDERNLFAGTVYEADDEEADRVWDNVDARMDARRKARRRVSAAAWKIQADGVCREAVEAEMAAQERARNPKLQTQFADLKRTLSSLNDTDWDAIPEAGNLTGKRRKHNLRLEENQNGKSYNVSDTVITDAINKKQTVGEVDDAADGTETDLVSIGNARDRVLSLQLDQATKDASNGSSTSIDPRGYMTALNSQVVQTDAQIGDIKQARQLLQNLIQSNPKHAPGWIAAASLEVHAKKMVAARKIIAEGCEKCPKNEDVWFHAAELNTPENAKVILGRAIQHVPLSVKIWLKAAELEADVSSRKRVLRKALEFIPNSVRLWKETVNLEDDPEDARILLTRAVEVIPTSVELWLTLARLETPANAKSVLNSARKKIPSSHEIWIAAGRLAEQSPAAVAKEVKMEDDEAARAAETQARQKLATQVDALMKNAVNSLRKNQVLLSREQWLQEAETCEQDGSPLTAQAIVKATIAQDVEEEDRMDVWLEDAERASKGGFYEVARACYVKVLEEYGDEPFVWRRAAEFEKAHGSPDSVQDILARGYTANPHAEVLWLMAAKEKWLFGDVQGAQAILASAFEQNEDSESIFLAAAKIAAESSEFAAAEQILEKARGQADTERVWMKGAVLARQLGKTEEALRILEEAIQKFGKFDKLHMIRGQIYESATPPNIFAARKAFEDGRKSCPKSIPLWVLGARLEEKSGATIRARGLMEKARLSNPKNDELWLESVGIEERAGAMQECPTSPLLWSKAIFMEQPQQRKGRSVDALKKAGEHPAVILAVARLFWSERKIEKARAWFGNAITADQDWGDAWGWWLKFERQHGEKERQEGVVEKCIAAQPHHGPVWQAVAKDLANVGKSTQEVLELVADKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8A0</accession>
    <name>A0A1E3K8A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035309.1">
        <property type="nucleotide sequence ID" value="XM_019172367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8A0"/>
    <dbReference type="GeneID" id="30189397"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="60179" checksum="84E22E6C649F0A41" modified="2017-01-18" version="1">MSSPQSAIRHPPPENPPGPSHDTAALKNDVAGGKTSLQGGEGDREAVAGEQQHNPPKTPFTPLQPTQTSLSQRPYSAFSKSTKRLIVVLGGIAAIFSPISSNIFVPAIPTLAQAFNRSESDISQAVTVYLIFQAITPSIFGSMSDSFGRRPLYVATLIVYLCANIGLAVIPTSAYWLLLVLRALQSTGGSAVVSIGFGCISDFAEPRERGRYAAWFQTGAMAGPAFGPLLGGVLTQSLGWRSIFWFLAIADAVVLIPLILFLPETLRSLVGDGSIPPPSLNTSPIVLYQRKQMAKRLAEEDGEMEPVVRPEPKPYRPFSTFMILLTPEIICCFVFTSLLYLQFYSSLTLFSTALKNSYHLSEVKIGLCYLPSGIGTLISSQLNGRQLDYYFRREERRVGGDYRSKPLLFNIEKTRIRCLAPFAIMSCLATVAQGWCLQAKAHLAATLVMNFFVGLGSGTNGSVTVYGQDIKPGKGGAVSAALNLVRCLFGAIGVASIQTMYKTMGAGWTFVLLTGLVILGSPLPIITVYKGRGWREKRNARHAKKAEEQANKAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8T2</accession>
    <name>A0A1E3K8T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035498.1">
        <property type="nucleotide sequence ID" value="XM_019172556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8T2"/>
    <dbReference type="GeneID" id="30189588"/>
    <dbReference type="OrthoDB" id="2568716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="37935" checksum="C1C99BAD1E3F1285" modified="2017-01-18" version="1">MAPITKGDLILVTGASGYISSHTAKEFLKQGYKVRGTVRSQEKGEYLRNLFEGLGQFEYAVVEDIAKDGVFDEAVKSVDAVAHLASPFYTANVKDPQELIGPALKGTTGILKSIQKNNPGIKRVVITSSVASVMSARSRKTPVIYTEEDWNVDSIKHVEENGVNSDGGDSYRASKTLAEKALWKFIEDEKPTWDAAAINPPLVIGEVIHQCDNPEKLNTSVHSFWEWLTGKKSESDLPAPGANWVDVKDVALAHVRALTVSEAGGNRFIVSAGPFAGQDYVDVLHKRFPDLPDIPVGKPGTHDEIVKDSNVFNGAKATKVLGVEYKTFEDTVVEMAESLQKRFADKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9M8</accession>
    <name>A0A1E3K9M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035807.1">
        <property type="nucleotide sequence ID" value="XM_019172865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9M8"/>
    <dbReference type="GeneID" id="30189904"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="24372" checksum="0860D19B6BB0B30E" modified="2017-01-18" version="1">MRGDGQAELEDGRVFDIATNLFVLFFFFRTCQCGSGTSIPRQGHPTGPKGRRDHSPADATTTKDSTPPLDLRPSHTQRSPSYRTSLSLQPCRDKNKRENWNVRSTDLMAKVEKLLPLMGLIADAMCGSYGSRLRHQPAALRILQAEPPPPLDSRHPTPNAQTGMDNAENMGGQAIQSREPDSFFGNPGANPLQNQDDRPAERPHLVKRLGSKIPSFFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBW7</accession>
    <name>A0A1E3HBW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027771.1">
        <property type="nucleotide sequence ID" value="XM_019180241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBW7"/>
    <dbReference type="GeneID" id="30197486"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129048" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="407" mass="39894" checksum="0925318EC5FE728F" modified="2017-01-18" version="1">MVSYTSALTAVLLLLPSSFGHPTLHSYHKRFTGVKLQSGRTGLCLAPLGNSTSWVAGTQISSSECTDEHVGVWDVSYGSGVVILSKTSGTDQLLVLDGGTGKNDNENLRLDISNNGSFAQTWYYTNDNRLAITSGNQCVDMGDRGNVQTYNCTSGNTNQVWWLLSDDGNETLSPPGSSSTAVSDAATSGVAASSSSGAEAGSSSSAGALAATSGVVSSTTAASGSASSGTAGSVSSSGGGTGDSDVSSTASEESSSSGSSQASSTGSGMSSEATGDASAISAGDKASTTLESDATSDSSGDASTTPISTATSAAAKSTSGEEAGSMSEAATSSSAKTSDSTSISVVNVSEDKGSSTSSTAKEDATSTTAQDAGPTVGADNGEGFVTLTVGGQIIVMQTEFAAAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HHN6</accession>
    <name>A0A1E3HHN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027895.1">
        <property type="nucleotide sequence ID" value="XM_019180126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HHN6"/>
    <dbReference type="GeneID" id="30197366"/>
    <dbReference type="OrthoDB" id="2575001at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="699" mass="77895" checksum="7CBFDB4B814A2D4D" modified="2017-01-18" version="1">MRIPYSPLRNAPFRAASVPRMTRRAISSTLPPPASEPLSIPLDKAARAIPSLSSTLTFTAHPRPIRHTTPSSEKTSLSKLLALCSSKDASQGSFKKADEAWVLYNELSIVYRRSLPNEQLHLIARNVLPRESVIKTFAKAPDTREGGVLRAYRRRMEKVAISLEQRVRVLASDILIRRQSPGAAPDPRLYKFLTSNLSKLAFIGEKSGCRAILQELKLRALSPSPLPPKYWNMAYNLALQSINKWLAIHCYRLSAQGEIQEAIGNLKTLIEEMKERGVESDEATGLILLNSARYIVEARKDETIVDGFETLSALVLEGGFGIRKTPLGWVGLRQNLPVQVKLAIIEHVGRSGEIWDLVGVYEALYPSREREVVRKAEEARVLVDVEEEEEGPTLSQMVAKEKEEQSHRDWLGRPLEEPFPSPSSSPSSSQIPIRRPFDAYLPPIPTPSSIVPTSTNLSISSLSPIAQPIQSDIPYSYIFKTMLHYPWVHREAPGARDVALLMLRVALREAHVQQALWLSSLSESDTPSSFSAPPALRADFRWFQAAWKVGRDTVNGKNDRIGFWGVLNGMIDEAESRLKEELEIMRTVVERAAEKENGSESEGESTLASAETTAYLGEIDQTLQELTAVRGEILHHTGVVVQKRNRAHLARRERTRTLEEQRIKEEARWPLEGGQQEDSGRISKVVFSAESGGGVAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HHV3</accession>
    <name>A0A1E3HHV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027874.1">
        <property type="nucleotide sequence ID" value="XM_019180148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HHV3"/>
    <dbReference type="GeneID" id="30197388"/>
    <dbReference type="OrthoDB" id="2596802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74101" checksum="3FD97F6728229496" modified="2017-01-18" version="1">MPLTMPPLGPLQPPGDTPRVPVRQIMAEFVPSALDFSSIDEEVSRDSTVSSVDVLAETEGDGVRIIKDTGMNDRFLAALDNQLPAHILASKRLLTIIFRKQALDERYGEAGNQHIYSERDLPVMMEETFWRYVNLVMESKALDKNLRGEWRSCGSRNGGVRGWICVRKVDGKVQALSETIMPSMLRDTSDHAGRVQRLLEEASKPGGMRVIVTGEKSVGVVEEDGAEVPGMEYWANCIAQFWEKYRLFDTANIMLLSSSEIYLPLERDRSAPNILRVGLSIARDAGMTGAGDGALTCLELAIASTLSLPAPSHVLPFLPLPKLKIENASSEGQGGTLAGVFTSMCRWAGIRGSKEAGKQRKAKRRRVSKQGQDLSENRFESVRRSSGSAHPFVWARLHFHGCSLSDSGRSVAQHFFGPIGLSDSSIYGWIDKDLAHPHLDDCTNIFSSPPLLPIADPPLTPRANPRKEAPITAAITLSSSPTFSVSQPIDASSASLTSRVPANHPDDLPPLVVKTMRPSTFDDAKGSAGYGTGAGAVDAWEAEVELYGGVLSCLQGHIVPRCFGAPRGLMYVSREWESREINFLILERVGSAVCAKDEDLPLLPEQTKLAICSLYEALHSVGVIHGDIKRRHIRQRADGSLCIIDFEGARRVSDGAWEDEMLADEMEEVKAMLGFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HIY4</accession>
    <name>A0A1E3HIY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027924.1">
        <property type="nucleotide sequence ID" value="XM_019180114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HIY4"/>
    <dbReference type="GeneID" id="30197354"/>
    <dbReference type="OrthoDB" id="2564566at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="96193" checksum="97894E94EF80976E" modified="2017-01-18" version="1">MSPQPPLFTQDAYSDVLIGIFDCLTLKEVVSFIRVNKHVHNVFRTSSRLQLSHTQRLFSVPPSTFRQGATPADSLAALKERQQRMDDFDPSSIISIQQDRYHELVALENGLLVFHSEVGRETAGETCFDESSEGWDVYRVDRGASDIDSLNRGAVRDQGLWHWKTRTSAEFYHIEMCGEDNLVALIFRPMKSQSYSTNLSLRVEFYCALPPLGTPAPIDGFLDPIPHPDAPIPFIELIFPVEYAKAAADLTFGPGGQLAVLMNDRDSEKTIFGGVWDWKKGVCLGSIPIAEHQIISTVSPCGPFAFTASTRPVPASVEPGLYDKALCDFGPPPPDDFPEELKGFVQCSFDAHILLPPSLGFPPVKPDPANDYEYAQTYPTMGCSWYMSDIPSAIPVVRFDLPIEDLLPHTLAMAYEPESFNILQLRYSPSIHESDTLGIFTWGLDDMSNVADLSSLLDRASEFAFRMMVAEMPRMKKEDVLRLVDLASFETGARTAIVAKAAKALVLMRYHGRLTEGGVWSPSGSGRGVMPQEGSEEMDEADDSSETFVDTTAGKDFVRFLESRYYGRQPRTNSKLDIRSPDTVSPLQPISTFDSPSHDPDQAPLLPQDLHQVADGSPSLAAIPSLPYKEWMSANHLRLGIDFTLSAMYGTREVRIVPAPRENMLDVFDGEEGEGGEEGEMRGKLKYVLSLSDYNESSLPDGVWAKRRIAGARRRELGAFKALLGSITDTDDPVAIDACRDRIRHKLSGFIHLLAQVDSCLEVEREKMLSKIVELDDTLGDDEDLVDMDVVRMFEAQKRNVILLGGRRAEVEERFQSFKNLLVEFEATGVRVDVEECDAQASRMEAGDSTTLESEFELSMEDQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HKS9</accession>
    <name>A0A1E3HKS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027937.1">
        <property type="nucleotide sequence ID" value="XM_019180083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HKS9"/>
    <dbReference type="GeneID" id="30197323"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="173" mass="19180" checksum="AB1DBAEB4041E0DF" modified="2017-01-18" version="1">MDPNVRYPNTDNYLFAVRLTTLVPAKKSVLGIQVCHLGMDAIVARKLLQLFDALYTHGETALDSSDPDVIIPTFFPVSGVEPLPASKQDLTDDEVFGFPSKPFPKSIQSYVADAMTSSRVALQFTKSELQALRNVERLNRFHIVYVLKPNIDVVLYDSVCADGKHVGVLVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HWP1</accession>
    <name>A0A1E3HWP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028191.1">
        <property type="nucleotide sequence ID" value="XM_019179824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HWP1"/>
    <dbReference type="GeneID" id="30197054"/>
    <dbReference type="OrthoDB" id="2563592at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="136" mass="15157" checksum="3B733C4A367C7110" modified="2017-01-18" version="1">MSTTQLTSSALRTLVPLEDIPPLTLGKTTRASSFASSTTSTSSIYSRAADDLIDRFATHQPQTPIHLWSGGNVRLGNMDLTLTTHDAELLMHAMNGDERFDFVKLTFLDEDREEWKISFMRSQVSSISPPSSVFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYF4</accession>
    <name>A0A1E3HYF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028238.1">
        <property type="nucleotide sequence ID" value="XM_019179757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYF4"/>
    <dbReference type="GeneID" id="30196982"/>
    <dbReference type="OrthoDB" id="10286124at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="425" mass="48264" checksum="B7D85613C923D9BF" modified="2017-01-18" version="1">MVRERSHSICVDVHPIFDAPDARLAIDSIPLTIADLTFPSFERSMKSLRRSDSTGSQATIKPTPKQRQAWEMMVLKQKVMETEATPKAERKEFDFTPVEIPAEKEASPSVKWPADSVLIDLSDDASYDHVPDVKEYLRLVGFTIMQATFTNIATIDPERRFDISALTGDELVQVGREKLANAQRRGEGIFAAYPKVSDISIPTNFPPWAALLRRNLHSIAEAVRPKFEEKDEAFAPISGRSALGRKKVRSLQKKRVVSGEVGARWSMGGKLDRDVLLRPGEDGPCERMIKTNIRIPIPSSLSHLEPGSSEYRRLIATLYRIDSHPAALALRHRTSVLKVLVKRKTLLLDRGFDVSFTFDYRKAYFPRDGEKKAKGDLKVDHDWSQYLENIPIVGDWSQAVEMRCAQKDGRYEAWERMRRETLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I978</accession>
    <name>A0A1E3I978_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07576</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028425.1">
        <property type="nucleotide sequence ID" value="XM_019179568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I978"/>
    <dbReference type="GeneID" id="30196787"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="13">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="674" mass="71963" checksum="94ED72B494412685" modified="2017-01-18" version="1">MSPDSQDLEAIARMQERQAQWGYPTGSLSPAESPQSYSSIPLSHSHSQSQGGSPHLFNFMPHQGPAGVGLSAGGRIGANANTGFMGSSVNPSGFGVSGGMHPGSHPFGGRPPTIASVDQSMLPAIFENHSGRGRPKSKLQKAKPQGLGSERKSRKKVAKACLACQKSHLTCDEQRPCTRCIKKGMADKCVEGVRKKAKYLMEGDERVSNRPSQASSMHSTPQSTTVSLPAIPQLSNTVHDAPTRIPDDVWLANAVGRDQQPINIPTALNITQPDIWAGTDLGPSSFPSSGGINGTAANNEYQMLDAMFASLSPVYPGLNDPLDEAGRQLLSGSNSLTNSNPLDLANTPLPQPNPTLSQNTYDQPWLHPSPQSQQSQGTYQTPPGSSIHGISPEFGGTGTGSGLSPGTWGSWSDSGPAGQIMLDGSSVGGGSGVDLGQVRGPGAVENRLGQGMGMGPRTASEIYRNVIKPFDYTQGYHVLMDYLAKHFETPDVLRVVQSLASFRPSLIALQMPMSEEDEVFLERSFQRTLLELEKLISYSATPTAVWRRTGEICYANPEFAGLVKRSEGELVGKGKFIYELFDKPSVVSYWENFSVHAFENTTQNFFQPISLSTSPDASFNSNPNYNQNQEAGGMGMGMGAGGAGLLGCTCCLTIRRDVFDLPSVVIGQFLPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9M8</accession>
    <name>A0A1E3I9M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein EncT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028449.1">
        <property type="nucleotide sequence ID" value="XM_019179592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9M8"/>
    <dbReference type="GeneID" id="30196812"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN85277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="567" mass="61227" checksum="2DA243382B91107B" modified="2017-01-18" version="1">MPSSLKTPELRQSRSLVSLKSSPASLSLSNVAGDNTNNTTQANESPDTQHPLAQLSPLKKSVLLFIFGLADFLDIANVSGVAVAVADITTDISLHSSQGIWIITSYSIGFSAFLLLSGRLADLFPAGIVFEVGFALLGVLSLVTSFVTSNKYGFLILRGLAGIAGSLSIPSAYHLVIHMYPETKEQASKLSLLGLAAGLGNVFGLVLAGLCMRASYKWFFRLIAILCLLSTAVAIWLLPFSFSSTYSKEKKEGKESIPRWRMLDVPGVVLMMGFLTCFILSLTQGPIYGWGAVSFIVPFVICWPCVVGFFFWVEAKISQKTAILPNSVWNITNSIIASLAVLIPMGFWGTSQLMYANYWQTTYGWSPLHVAVACLPQGVMTLIIGGMVPIVPAIIEKPRWSIPIGSILIVIAEVLQLKSEGGHGTDYWRFIFPAFVLGSAGGMIVIFGSQINLVQMCPPEMGGVAAAWISVLFQVGGALTLAVMSGLESTNPSTFMQSGAKVCYFIIGYTIVLAGIYVGFYKTPKSLEDEHKEARERIRKRDGDGGGDDRESGVVPDGKRGREEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAP9</accession>
    <name>A0A1E3IAP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028541.1">
        <property type="nucleotide sequence ID" value="XM_019179503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAP9"/>
    <dbReference type="GeneID" id="30196720"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="100" mass="10965" checksum="19400F4AA66495EA" modified="2017-01-18" version="1">MILLRASKRLQLLGDFSAASVIEADLDIVTTALNDWAATSFSTSDNNAVDQISNNDPVKNYIDKGPDVAALNGQMLDKLRGLGLDEWLIAFEGSERRDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB49</accession>
    <name>A0A1E3IB49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028549.1">
        <property type="nucleotide sequence ID" value="XM_019179511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB49"/>
    <dbReference type="GeneID" id="30196728"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="121" mass="13607" checksum="CFEFC426A237BC73" modified="2017-01-18" version="1">MPYLPFGTPSAYTDSFPAPSPKHVTVTADTCFNLTVFRDIVRQYRKLDDQIIIRLNRAQAELRDQSRTSGSSWIPAKSMDGAEGMCVKLWAEMMGQPIAPLKLETFPDMMKQRGGFTDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBV3</accession>
    <name>A0A1E3IBV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028625.1">
        <property type="nucleotide sequence ID" value="XM_019179377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBV3"/>
    <dbReference type="GeneID" id="30196586"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="895"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="698"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1268" mass="139229" checksum="0FA73787E7641E05" modified="2017-01-18" version="1">MTAPPSHPATYINFPFSLILERMPSEKDPNVFPPKTWLERAKYYGDKATLAERKGCKEDMYVWYTLYCQCYLHAGTHPDWGEAKKKDPALAARYKEMKPMYEQYFGKAKVVKEQLRAAEAKPTTSSSSRPHPTRQPSGPETGSIGNLRDRMAALAGHGMAVESVQPTAGAAKRMSRDMPPPKIVAKPAALSGNYLSGAGRARSSSGSHKSPTTTGGAQVIVTASSRPSAPSPAPSFVSTHPTGSSMRSNNQANLGPSAGPSNAASPPSSLIHSASVTPTDRAPSTYTTPQASPLPPPPTVRLNPSPRPPNGAHPPAPPAHQTFQEFERNFPSLSEFTKEWEEPLPNPHSPNGDGADDRSPNGYSNGDAGLPNLPSVPTSRPGLPPPPSKPDFGSFSPRDERSTAPSPVSHNGPSRVDDVAGPSTQRPESSAGRAKEDDSRANGVNGKTQLNFPVAVPTPPTQARSPLPPTPSQSVPPPSLSAPPREKPRFPISNSIAPDQLRGYFLNPSVEMLFLDVRPQEEAKYHVAQEYESRTLKEVNVVQIDPTLLMRDGMDIPRLEDSLSLSPPKQQTYFANRDKYDLVIVYDASSTNWPTSGPLQRLWNMFFNGHDPKKLQRPPVVLIGGHNGWIEFIKMRAGRHQAHKESRSGVLTSADVIVREPDVVSPVTSGQKKANRDMPVYQPSQYSKTITENFASAPQSMTGESRYSQSHTQSYPSSYKSPPPSSHQHHRTGSSYSVQAPIAAPPQASIHPGPGARRRSDYIEHSGQTYSGATPSTSSTPQPQSQSQATSPTSNYYSPPSTSIAQNLTSPRQGVDYPQAHALAKVAMPPPVARPMERHDYSSMGGGYMPGQGHGQGQGQGHLVKSHAQRDLRQNGVVAGGEKVGYWLDVVVGLTGLKNLGNTCYMNSTIQCLSATFPFATFFLDNTFKKSINLDNPLGTKGELAKAWAGLLSVLWSEKYEFLSPMTFRKQIIQFAPQFLGTDQHDSQEFLSFVLDGLHEDLNRIKKKPAPVEMTPEREAMLETSPPEVASESEWQIYRQRNDSLIVDLFQGQYRNRLQCLTCHKTSTTYDAFMYMSLPVPTGKTKVVVQELIDEFVKHEIMEKEDAWYCPRCKTRRRATKTLSISRLPPVLLIQLKRFTTRDGRFWDKSETPVIFPIRGLDLSRYLPARRQDTGAGGLDMNDPRTQVGPFKYDLYAVSNHMGTLSSGHYTAFVKSREGWKYCEDSQISSAQEKDVVVSSSVSWVEQGARGIYPAWLVQLLPSFGYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDX7</accession>
    <name>A0A1E3IDX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028789.1">
        <property type="nucleotide sequence ID" value="XM_019179172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDX7"/>
    <dbReference type="GeneID" id="30196370"/>
    <dbReference type="OrthoDB" id="2578193at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="215" mass="23292" checksum="86AE3E9B889D6EF0" modified="2017-01-18" version="1">MQLRVPPKFHLLSSQSLLAVVLHLIPRIHLYSPTPTSPSPLASGPSSAPPPCWPPLPGFPSLSLLPPLLLVSASPPALSAKPDQRHTRFEVNESGIGYTQDRIELRSKTFCFKGAEKRVGCLYFLRRVSTLLGQKDGSRFRRRPWPKAFVRTPSGGALPVSFHSLGALPDTAILTCGFGLECTSFEKSQGAVVSDSIGQILHGGGGIRTQDYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IED4</accession>
    <name>A0A1E3IED4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028654.1">
        <property type="nucleotide sequence ID" value="XM_019179406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IED4"/>
    <dbReference type="GeneID" id="30196615"/>
    <dbReference type="OrthoDB" id="2577343at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="42539" checksum="D9F33C51460D4353" modified="2017-01-18" version="1">MLINQDSRLLGSFSWEIISGLWSDPQDHEFDINEEREGRAPDIEFWKEIDKGWWFDGDFVVRTAHQQQYKVSAHRRSARHIKEGRDETSGAVMYRYKEHRSTRAAALIKQFAPVGKIRSLWFEEFIDEKESSATFLCATQMSHFLTGLVMTLHERRSWGTLPLEMERELILRYYELIRSEPGELGQMLRTISHWEEDHHKPRRWVPNATFAMFKPLDPSTVFYQECEHHFPMAIPSTFISVAKLALIRHEQGMDKVWWDAWWLVRPDMRRYFRINFGVRYDYLSVREEDIYLRMNYPDGRQVVESDTAYRNFPKFEPVDPWSCQVTQPNLNEAETLTRIRRLPETSMPKHMADSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEV0</accession>
    <name>A0A1E3IEV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028863.1">
        <property type="nucleotide sequence ID" value="XM_019179105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEV0"/>
    <dbReference type="GeneID" id="30196302"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="946" mass="104467" checksum="8E6C99AA8B2E1D2E" modified="2017-01-18" version="1">MASEGAYSSRPSLLSTNTPRTPSHLTPSPVVPNFPFNHSTPMKRPLPPESHASSSGYPERKFSTDSTSHIDHTQPQPQKKKRVSLSCAQCAKRKQKCNREFPCQHCTKVPELCVPYNPQANSNSSSGPDPQTLARLESIESVLSVVVRHTSGITHYEAVRDWITSPPFQKHLQSAPSTPASPHNLMTPQASVPGPSRPMTAYQPDAQDPNLLERGASSDDDGLARVGKGWLGEIDGGLPENMDTDEKVKMKLDIHGTPAENLQRLITDCGVSPHKIAELVQELPPKPFADKIIDWFFEKLNFIRYPIDERLFRASYDDLYNKATALDPSNVRALPLVFIVLALAVRQAPDKWAGDEQTRRLSSLRMYWSSRRSILIATAVQSESLELVVSRLLSAMYLVLIHDRRLTECWSQLGASLRTAQAIGLHRDGSKLGLDPYQTEYRRRLWSYLYHADKQYSLVLGRPPSISDSYTDTQAPSNIDLTEYNPALGLPPAKPFHEPTPALFLILRRKLAVIVGRIVHHFQKLNEPAQYSDVEKLQQELDLFVEQLPPHFRMHDPDKALDKVHFWLPVHRFMLLTEVLVTTIILHRPWLLRKLSSNRYAASRTACFEAAKLDFQIRQDFQREVPDFKLFAITGNFKMFNSAMIAGISAIIGPRGPDSDQMRKILTTFLEENPWHEVASKDATTRKEVQIIQTLSRRAAKIFEDSFGPGEPALHDKDSVALLLALRQSNDSSTYSNAYPKGVQPEDAPMPGGPGIGHNKMMYPPRHWGQTPNVAFAPVHHGGINQSPASTGSHEDDHSQKLLDHWINANTSMAVGGSSFNGGPIPTLDNSGMGYLPMSAMSGGMTPLSLSNGPGLTPNPALSAYGGGPFSSFMEEGGGNFMGHTSGEYSYPDQFGLLAVEGGSGQPSGRHSTEPGAENSDEYWNALIDGILGTTGGMSHGNQGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IF88</accession>
    <name>A0A1E3IF88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028759.1">
        <property type="nucleotide sequence ID" value="XM_019179278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IF88"/>
    <dbReference type="GeneID" id="30196481"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="41882" checksum="56FD35259DC05EAF" modified="2017-01-18" version="1">MSSSRPSALPHLPHDVVLLILDHIDDTAGPSTLASLARVSRSLHRKFIPLLYKSITLTQHNCSEFFYGLSPADTINEDEREEWWEEELEDKKSAVARRLAMLGYVQNVRLEDFEAVTICHSAIATFLSLELKAPPKSWYDPRKPTDDTRSRRLLFHSRIPTNVHLSSNLLDSLRTSEAPLNTKTWWIPLLQRMLRTSGVLSMEQPEGPAMPYVSRCLEPICRQICPRLLVLDSFEEGGLGSMLSASQRGVAIRFRDVDVNSRINEQYFEALNLISIHMRRTPKPLYYIIYNVSSKGVPVSFGVPKHKGVPVPISEKERIRVSIVSYAFVLAAQSPRQRRVKLKVVMAGVESEVSVDKMRNDLVEFMKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFP0</accession>
    <name>A0A1E3IFP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028992.1">
        <property type="nucleotide sequence ID" value="XM_019179074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFP0"/>
    <dbReference type="GeneID" id="30196270"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16649" checksum="D8E54BD3B1CD73A2" modified="2017-01-18" version="1">MELGSTASFQQKAPLGPTPTSASATSSEALIKVLEEKIKKLSLKAAPQTEVIYTSVIRAREPEPFSGNPDKLEWFIFHTQLYFEADSDTFDSDQRKIIFTQPRPAFLLDYDLLIAQLRRKWGVPNVRGRGQRNRRGYRQTDVAYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHD5</accession>
    <name>A0A1E3IHD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028925.1">
        <property type="nucleotide sequence ID" value="XM_019179167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHD5"/>
    <dbReference type="GeneID" id="30196365"/>
    <dbReference type="OrthoDB" id="2577751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="518" mass="54320" checksum="8D296AD0D853C28E" modified="2017-01-18" version="1">MFNAINHLRARVATLFAATPASFARESAVTEPVSHASHAGVSSERSVQVVPAGSVSAPAFVHSDDGIDVAVNHVFHAHDALTTSTHWVEDDYLMTVRKTTLLDEPARTCANRQSALSSASSSTSTALGQGRGAGIDNINITSATGTHADRQAQSRPSSGPAPRRRQLDFMNATHAPYPRGSTRVQVIARHREQIKVTSGAIRIPTANGSTRAVINGPRVSVAALCNALSGATPATATASSSRSVFAPDVIRRAESPVGSDRAIAIRPKPSFSSAPRVAPPARLSLRGPPPVRTILKRRINEVPNDDTESELARIPKRTRVTPPLQLVVSAPRQVSSSSSTSSSPASDIILTPPHQDVALPVDPPSPRCTKRTGDQVDEDADAQNESSSELPRVTKTIRFDTVPASAGDANYSRADTRTAFVSPPRAFLLGAPPFSPLPSHPVVPETETVTAQGTHATFAPPPRAFMVGAPPSTPLPCTSGRESFLARGAAAAPPPFFSRRAPAATAAALASSATSELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHF5</accession>
    <name>A0A1E3IHF5_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">L198_06990</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
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    <dbReference type="GeneID" id="30196201"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="110" mass="12390" checksum="07DE36E3841100AE" modified="2017-01-18" version="1">MLWGLVQDVAAQETRRRSWEGCRACDFIDQLVDPLPPVNPQASLPAPSPDRRQTRCGLLKGPVVAQRSRKSQALRRRLQRVQLPRGLEAAKEGQAGREAGRARRKRKQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ61</accession>
    <name>A0A1E3IJ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029294.1">
        <property type="nucleotide sequence ID" value="XM_019178811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ61"/>
    <dbReference type="GeneID" id="30195969"/>
    <dbReference type="OrthoDB" id="10536560at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="44342" checksum="275E617D6430C2AC" modified="2017-01-18" version="1">MVSNVSRTSQQVNYHNDPDISTDLVMFSSTLASGSRLRDDVSGQAFVGSGNTSNIQLSTGEEAPPADWAPLQASTALSSQIFPSGTPLQDINQPPQLVSERETEDQDDRCVIDGEVQEDKSTPARSHTVGGTPQRRLNPPESQGSDASGDGAEEWEDNDDEDDADDVSSTGTEYSRDSNIMNEPGWRRHFNFPRRSRELKARTVLFRQEIQALRAEAKAGFRLYASRRFRGSEQASRLIERARDGKLLDPRISKCILLWAAENGKTTTIPGKRIKPSITIDQVVKLAETMLSCVADQRYDERLMAQSASHDASLRALNRQNKKRTERIREKEQAVTTRESELEQRRGEQEAELARRKEEQEAEFARKEAQEAEHRSRMRELEERERRLQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJK6</accession>
    <name>A0A1E3IJK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029347.1">
        <property type="nucleotide sequence ID" value="XM_019178646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJK6"/>
    <dbReference type="GeneID" id="30195803"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48031">
        <property type="entry name" value="SRA STEM-LOOP-INTERACTING RNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="894" mass="96741" checksum="1C8D45570ECBB0A1" modified="2017-01-18" version="1">MATQDQVTKRLHISGLKPEITAAHLRDRFSLFGSVSDVEELQPDALGDPRPFTYLTLQTTPAQLKRCLNTMSGSHWRGALLRIAEAKPKFDARLHAMNNPAPEIVDKKIEQKRKRVMRARAEGVGKLAQDMYLVDAQRATKKKFWVVVEDGGETRVVRPMCMRPDRPIGVPGKKIGLKKRAMAPARSFRKVINPLKWGSSLSTFPLSFPTSIGEGEWEFEGFSDEEEEEDEDGRVPIGVWRKVVDSEVVDEEVVRGKKRRVESDGMDFDYGIDLALDDFAVGSTASTPLFGHRELPTGRESSPLFPSHREEREASPLFPSHQQEREISPLFTSRAPPAEEADEEEVEAKSSPLFASRAVEASVEPEESSSAESSPLFPTRDLPRSANPSPSTQAARSSRPPSLRLDTPISSSPEPELEVTVPTTTRLPTPPPSSLPKPLVHQAKQEKTAALSVLDGLLDSFQVSPEREKLGRDSFRGFLEESDSEEDGEVEIGRGKKKEKKGVPAESVVEKDEEIVVEEPDLAPPPQEATEPSDSSEGSSSSSSGSDESSEDEKMDVDKPAGDDKKEESGDDSSEGSSEDSSEESGSGSGSGSSSGSGDDSSDDSSDSSSSDSDSDSDSESDSDDSSDDSESDSDEPAKPPAVDQPAQPSTLKSMFAPAPATTSTSLFGLPSSTPATNSAGFSLLANLAPDVELDDDFDIPLPSISGPSRPAQGEDELQPLPMVAGGRGKVKLDLETAGETPLFFTLPGDREGAEREKGRKKGESRNGFNELFFGLPKPEVEEAEEGYGGRGGHGARGGQTQGGFGQGGDAQGQGWGQTQDSGYRTRLHPSQLHPDLPEGEEPPILGFFSQPREDTKAMKALWEGEKAALTQGWKRRHREARKMRRRKGGEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJL8</accession>
    <name>A0A1E3IJL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029341.1">
        <property type="nucleotide sequence ID" value="XM_019178640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJL8"/>
    <dbReference type="GeneID" id="30195797"/>
    <dbReference type="OrthoDB" id="47885at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13769" checksum="C001BE08063B4F74" modified="2017-01-18" version="1">MSDWKFDVHQQTTDHTFDDERGQGSVRGMRGRYNKRGGSDECRLYPPAPLSSFVVDSGASDHMVVDWDLLTNVRDTHPVLILVGNGELLTSRQRGRLTIGLSVQQTPDTYRWSFHHGQAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJT6</accession>
    <name>A0A1E3IJT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029336.1">
        <property type="nucleotide sequence ID" value="XM_019178635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJT6"/>
    <dbReference type="GeneID" id="30195792"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="40643" checksum="4F052CD22194A2B6" modified="2017-01-18" version="1">MVLLKSPSPLLPSSPDLRWHRSDRRPSILKYTLLLLTILYLTFLAFTFDPSSLPLPASVAELTDSWNGEYSWGPAWASSESGGGGRDGREAYVTFLSSVADPWYLLSTRLLLWQLQHYPSTADLARPFIVLATPSIPSEVCEQLEKEGAQVQKVELLDGFPLPEGMEANHHWKDQYTKLHIFNQTAFSRLLYLDNDMLLLKSLSPIWDNVPSSFEGVGGVGERSKGMMAEDDTRRRPEEGEVRDYLNAGFLLVKPDGETFEELRGVREYNPFYMEQATGKVIIHGHRYKTNSSLTFLVENNCTMGTMRMSSSSSSHWDSTDEQCRLHAKMWKDEIDREVVDLWEAKVGQMEDYFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK87</accession>
    <name>A0A1E3IK87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029189.1">
        <property type="nucleotide sequence ID" value="XM_019178912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK87"/>
    <dbReference type="GeneID" id="30196096"/>
    <dbReference type="OrthoDB" id="2560037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="73" mass="7315" checksum="F610B03AEEA759A6" modified="2017-01-18" version="1">MPPSIADIAQRSVALTSVTLCVLGVGLTAHGIGYRALRARGYVGGPDVCGSLKLAREPKAIDSPSGSPSAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKL3</accession>
    <name>A0A1E3IKL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029429.1">
        <property type="nucleotide sequence ID" value="XM_019178522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKL3"/>
    <dbReference type="GeneID" id="30195675"/>
    <dbReference type="OrthoDB" id="2537650at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="542" mass="59243" checksum="7A5D6ECE8FF90D9A" modified="2017-01-18" version="1">MIVLSADERRFDPAQDGTPVVMRSVFRQLFFCVVHRMLGYYTSKRRKSSSLASPPSVILQSPAYADAIHDSPASTSFASPRLQQASPPSSSRDRSHSPNAPITPVGGHIGLRHTSPDGPGRLVAAKDFAKPPRSDPVAQDGPSAKELPSIHQDKDRSTLNSEPFTLLSEHTTSRSTLPTHAPPPRPSRPIDVKSIPPASVHDAYVSGFIKPSVALDMGVGGEQHRPSIHRSSSAPGEANHALLPSALPQSPEKKKASKAVIPQPVFEIFNAEISEDGDNLCRNMRGYLDKAFKGQEEVARMHLALEALGENDDQVGKENKEGGDEAKVEMSLEAREKGVDEIMQKLDALSDSLRTYHDLGTPRLSFQHPHPQGFRPRTNTVDIGTLSQHPTFDFPHDAPAEEQNSPQTTTSQRPSPPTFVRSHSDVELSPLSKNPARIKSPLRNAFIPSSAVVSDEEDEVSSEAPKLPRRGPSANLPPLRLSREPSLDDVGKGKGKEKPKTFWEREQEMDRQKANKQTWLEDVGGGMTDSPVEMGTRGQKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM90</accession>
    <name>A0A1E3IM90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029626.1">
        <property type="nucleotide sequence ID" value="XM_019178470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM90"/>
    <dbReference type="GeneID" id="30195623"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="197"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="47574" checksum="C29278F96CF644EB" modified="2017-01-18" version="1">MADCITIATDLSFKDQITELAAHLSRSLPNADAAAIREFVGEFESKASAEGADQKAIVKSVVDKFAELNGGLEGAKESEVESSHFLLQHVLSSVYEQGSEEYDQAVKNVNEAVRKGAQEATKHTRAEAGSRVLINTYNYLPATSHLRPSTLLALMSLLSTTLDLSTLPLPTSTLIPALASWNIPSAEKVEFLGTAAQLYSSFGDLSKALELITLALKESVEPALVEKAVFLSVAVPTKFELDDVLAIQGVPDQLGQTKSLVELFEGDEIEAIEKGKKWAVANASLVEGAGIEGFTGENVLRKLRLIALVALCEKNETRELGYAPIAKALGIEESEVETWVIDAVRSKLIVARISQPLSIIRIQSISSTTSSSRRFGSAEWQLLEKRLQQWKKSVGEARQVVEEAEQVAQQGLGQQRRNNGGKRREDKREKDEKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INH1</accession>
    <name>A0A1E3INH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029671.1">
        <property type="nucleotide sequence ID" value="XM_019178233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INH1"/>
    <dbReference type="GeneID" id="30195379"/>
    <dbReference type="OrthoDB" id="2576211at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="654" mass="70199" checksum="5C4FB1C7A255C5FA" modified="2017-01-18" version="1">MHLPVRVHMSSNRDSLLSADSAYPSTLFPLSMSALGLTDSPLPQRHRKSPFVGSSPSSSPTPQKPVRATPSKASLRQEATTNAAAKVVHQQRSAESVRSSHQRRTSQSGTKENQTAKAVGATKNTPTKAAPRASAPQAARTSTLQVVQPDQRVTSRPSRTPKEAPLADDWEEQLTRDANKLSLGTTPQARAREEPHQLPEGDKEWERLGQAMSDSRKKEDQSRREISRAVALPPSTPRTPIRAVVNGPDLYSPAPFFSPNAANSDLQTSSPHVARHGAELLQKAQKEYEEWNARKEEREGGMEAGSRDWEPKTREIARPSALSPYNTLTFSPDEEARNFEQYHPGKSSSSRPSPTKATQRQDMPSPRPDDMVDVTQAQGMAADQYMQQYPGANDPYAYPYWDPSYWWAMYGGMDPMGMGAENMQSGHYSGGLNGQAGGSSELEEQQAFDLSSMMYNPYQWGGGMGGGMMGHGQNGYPGGQSMYGQQSMMDGNRSMGMGSPSAMGSGQTQAGGGGDLKAFDPTKMKQGRLGHYGYLEGREELAGPPPGYAPAGIAPASSPGPATATSHRGGSTVGPPSSAGYGAGSSWGDSSNNPRARYDGAAHGIGYVQADLDSPYPRAPSGLGTNAYSRYGADGSVMNGDARVSQRRIREGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INL7</accession>
    <name>A0A1E3INL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029704.1">
        <property type="nucleotide sequence ID" value="XM_019178266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INL7"/>
    <dbReference type="GeneID" id="30195412"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="205" mass="23108" checksum="3FF83201D14D6132" modified="2017-01-18" version="1">MVKHNNQLQKNHFHKDWQRRVKTWFDQPGKKKSRRVARSKKALASGAAPLQRLRPAVRCPTQRYNIRIREGRGFTVSELKLAGIRRKEALSLGISVDPRRRSKSEEGQALNVERLQEYKNRLVVFPKKAGKPKSGDATGDDLTAHITREALPLPASYTPEAPRAITGEEKEGSAFTALRLARAAQRNEGARLKRVAEKEAAEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INP5</accession>
    <name>A0A1E3INP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029749.1">
        <property type="nucleotide sequence ID" value="XM_019178311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INP5"/>
    <dbReference type="GeneID" id="30195457"/>
    <dbReference type="OrthoDB" id="2578108at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="241" mass="26976" checksum="EC8364B76F6F14B7" modified="2017-01-18" version="1">MPSSGPSRCRNRPLFDPYPREAPIDVQSIQKDMHIPQRAFVRCRCPSCPPAGRVMQYRTWLNWKADHKFESASQPSITNHRPAEAPTFQDASSDVLSLVADHEQTASALGDETMDGLGAGDVGSDPSFYEGYDDLPPLPPDNDAIGETEDRLRSILARWPTKIPECLIPTYSGRNENPYRHHFELRTTDPMATMPLLYRVFAAFIVFLTAFAGVAQRYGDTARAIIEVIIKLAILEDRQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INQ3</accession>
    <name>A0A1E3INQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">L198_06251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029755.1">
        <property type="nucleotide sequence ID" value="XM_019178317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195463"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="387"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1450"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1476" mass="161838" checksum="8D5108249197D2FD" modified="2017-01-18" version="1">MSDTPHPAQDPPQEDAQLEQDLDQQQELQFPAVVVRIPAPTCPRTVPKQDGAPTDRITLYPQPGETIQDIKLLINDWVGAYWLGPYSLRLPFVKGEDGKGQVYTKRKDFSEVRAGEKLNEWLEVADAFEHVAEGEERVLEAIKEPYGEFSARQSILRLIELIAPAGTTANTLSNPLGLSAGATIFERVRDGLSADAHYEEVEVALPSGRKGKAGKKEVVKVKRAVTGDRAHAFADFKDWQPASFASLPVSSASSEIAPAVRSIQVSPFNPPPAHLRQQGHQLYLTVSLLEGETLTLVCTTRGWYVSKSNVNNFDATPRDAAAPIHSLVDLLHNISPQFSERISALPPISLESPIADPISTVAPPQAQPAYPFLASLPKPATTAEQLRTQLAFLHTGAYGPEGVDSARDWNEELQGIRELPRSTMQERVMRERMLQKTIAEFDTAAIRAVLSISSGDVPPINPAEPAEAYMYLQSNIFVTPGYNDALDAYAHLGGDGAMRVSHGKDAAGIRAFNKVDVDGLYTLGHTVVDWMGKRWVCQSVLPGIFSNRRALEEEAEAKEAKGEDKDEKKEDWVDVTASPKTATSALKEGEEAEPELDNPMMIYGLDSERPTTVHWDALTHKLFATYAALNKLAPHSLTSGTGEKHEFYASAEVKGLKGQDGRRYVLDGQRTSPVDVEWLEKDVEREGLGEYPHKLVLLRPELVEIYWDFELKRWAKSVSDKATKKQKESEDAEKAESGEKEEVKNDEKTEEKALVDEHSPAASAAAARRAEEDAPIDTSVIGDIKDFKLLFNADAFVPQPPAKEGCPAPVAINDESDPSVKAVRDASKYLRELAIPSLVYDVMIGVTSGVMDGESLSKHLHLRGVNVRYLGKVAETIESFSATKEGEKQEAKGYLQALQSIVYQEMVFRASKHIVNDLIKTLQPDQATQAVSHFLNCLLGSSLNPSPTAAYSPLSIGATEQEPAYVSLTVEGLRKQIREEVRMRFRYELPEAFLEGGIRRKQLLRELSLRVGWQMQQREYYFSKEEQDAVEEVKEDKKEKNKKSKAKTEVKRTTTFEPQDVLTLLPIVKSTAPSVSVAEEILAAGRNTINNGNVNLGLEFMLEAIQTYESIHSVIHPEVAAVYNQYAQAIHQIARIKIAQLAQKEDASPDEPLGVDVSTALKLQRQAVVIAERTLGIYHHETASYYFNLAMLENLEGNSQQALRYFKHVLTLWDVMYGRDHPEVNTVLNNAGIILQTAITDLPSSLALHQQAHESTSSIFGSSHLQTAQTLNQLVQSHFLAGNHREALTSAEATHTIFLAKLGEEHTQTKESLRNVELLTALIDGAEKQKEREEMIKKDAEERLKAARGQSQGLAGRLAGRRLGQQVNGNVPSGVRVIDQQTLAALTAAAQNGQLPASAAAAVAAAGQALPNGQTSAEGAADAAAVQGQGPRIGERGTENLEELVNYIQGGSAGGAGGAKRGKNALRGKRRTGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP90</accession>
    <name>A0A1E3IP90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029655.1">
        <property type="nucleotide sequence ID" value="XM_019178499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP90"/>
    <dbReference type="GeneID" id="30195652"/>
    <dbReference type="OrthoDB" id="2577069at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41119" checksum="F69E6C84F8D05F5F" modified="2017-01-18" version="1">MAIDTLDTLPSEVRNLIFEYLQATTHKPTLSSLMRVSRGMYAKSMPLLYERVRLNASNAEAYFGRLTANGLGAIDEEIASHKPHLSHYIWQLATVDCEPPLPSFVPSPIARKICQIWSTKDVFLEDAPTVAYLQQAATSVLHLYRQLEQNLDGQVEDMKYVSEYVLDDLESLVLGEPLARSLIHYPKVWESVANTIREDIDTRSLCLRIPADCASASAAQYCRDMLSTNLDPENICVLCIHNANPLDYMFKLNVYESLHFFLRPEDSPGMLSHEASIGAFMSSLLASIKESQSTLLLPDQIHFYNSQFTAVDRVSHQSWSFWDELEREKKDRAATPGRDLHWPVTLKLFGTDEKVACPVCGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPP0</accession>
    <name>A0A1E3IPP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06349</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029570.1">
        <property type="nucleotide sequence ID" value="XM_019178414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPP0"/>
    <dbReference type="GeneID" id="30195561"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="217"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="415" mass="46721" checksum="559BB6C3500A04FA" modified="2017-01-18" version="1">MSSDFYTSSHNKYWLVTRPVILDARQTDLKYCSPRQLYCLYIFFSQLIQKLGKRLQLRQIPIATACVFFRRFYLKNSICETNPYLVLSACVYVAAKVEETPVHIKSVVSEARLIFSEHNIKMFPAESNKLGEMEFYLMEDLDFHLVVFHPYRALISLTGREPSDTGKWDMSRVEEEQVMRKKEADKKKARSDEIRKGGAKGQVTSATLDDDDESEEERIRRLMGRGSGEGTIEMDEGVLQISWFIVNDSYRTDAILLYPPYIIALSALYIAFCLTSMSNSTSRTRNASTQIHSFASSLSTNNQLHLSPPPASAAEFLAGFQLNLPMLFGCVQEIVGLYPIWEAFEPTLRGAQGQQKGTGGLAGTGKGEQKDKFGVEEAEALVRRMIEGRMTDLGHPDDGGADRPGASSRKRTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IPQ3</accession>
    <name>A0A1E3IPQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029590.1">
        <property type="nucleotide sequence ID" value="XM_019178434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IPQ3"/>
    <dbReference type="GeneID" id="30195583"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="236" mass="25813" checksum="92458A9D345EDF00" modified="2017-01-18" version="1">MKIVSQEDVRGYTDSTIEGGLKGAVVAVALSVPGHFFFKKNVAAYRTLPLPLKCLAYVMVGVPCISIFAEKAGEAYNRGQYTGVGQKELDYELEREREKWEKLSSWQKTTDWAARHKYGIIGAGWAASMGLAFGIVARNPYQSTSQKVVQARMWAQGLTVALLIGSAALTGMPTGSNGDSAVHTPHVDHSWRRMLEMDESLTAAERAQLKDESDPNKLKDLHESIAKRKQAAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ20</accession>
    <name>A0A1E3IQ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_06016</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029802.1">
        <property type="nucleotide sequence ID" value="XM_019178083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ20"/>
    <dbReference type="GeneID" id="30195228"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="295"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="570"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="687"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="775"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="955"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN90700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113264" checksum="726FC59348F4425D" modified="2017-01-18" version="1">MTLPAPVGYLYWYTTSIILFILTLYNVLYKLFHHARSKGFIRTASSHDSRIGRVWRTGRALVDKHVLLAGIRRPPLKFWKKRPSKWQIMPSTEVWWRVGYSVGFLVLAFYRTGWDRHTYANQAAWLAVAQIPLIIALAGKNNLISFLTGIPYDKLNYIHRAAGNLCLSGVWIHAGGHWSLSHGWSKASWSSALAHWGFVGIFSITLLSLISIQPFRRYVFEFFLALHIALVALMLAAFVMHWKAMDVWLYPGVGLWAADRILRLLRIVYYNHIYPSKAILPPEEPSSPLSPKRSSNCKTHTTAQITLLTPSTLLLTIPRPSPRLSWNAGQHFYISIPGVSRWPWEGHPFTAASVPGMMEEDGAENDQLAFIVRVRDGFTKRLLRYVEENLPGGGYGRKGMEKQAVGVRAAVEGPYGPRNEVREYDGVLIFAGGSGISFGVATLLQIIRDAKKGKSRVKHVTIVWMVTSRLHLDWITPLLSPHLKNLPPSLNVTLKIHITRPPIPLSSPCPSALPPPALRTSTLSNPSEHLHAQTELEDYLHRRVHERSEKHRRKRRWSVFSWASWGPRMGRDSAKSGVNTRRGTHAEIARGAVRKESVSEPTTGSQTSSTSRRSSHGEIHHPPPTNFAWSEHYTSDRMPNAQYISPIHSDHSGSPSATPMRRLSTAPMPPVMEGDELVLSEAAPLPGIEEVPGKGTAGARSSSPTSGEFTEEGDLATRPRTLSPPPFPERRRHVSISDAPPLISPSPRQASSASVNFDRPRPSILLTSLKLRNHRSSSHAPGLLLDPELLAPPMSRSSSAESVDSTTSASSGRSLASFTAPDTPPSIPDLLPVLGLGQDSTTEESSLEHISDKEEEDVQRPSTPTLLLSQLSSATDTSPEEVLQGLALIGSIPDPQKRRESLEQWIGGVEGDLRKKANVLLGLDGEGGVVRWKTGRANLRGEIRGMMDIVSLPSGQSFEKKGASPQKDAEKNQPESVGERAKIWVGVCGPRSLLDSSTLAVREELSGKAVWGGGVRIDFHAESFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQD3</accession>
    <name>A0A1E3IQD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029668.1">
        <property type="nucleotide sequence ID" value="XM_019178230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQD3"/>
    <dbReference type="GeneID" id="30195376"/>
    <dbReference type="OrthoDB" id="2577922at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="87" mass="9898" checksum="F66EB66754707F28" modified="2017-01-18" version="1">MPKYPDPDDDTDSMDSDLTSSADAPLEQIMYLLSDRLSIDRADNLHLVGQYLKISGYFKGMSFPPKLIEDYYRSLAPQARDPKILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRW6</accession>
    <name>A0A1E3IRW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029980.1">
        <property type="nucleotide sequence ID" value="XM_019177941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRW6"/>
    <dbReference type="GeneID" id="30195077"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="31669" checksum="0B269660CFCE4FBA" modified="2017-01-18" version="1">MAWSLDIARQDQDAYEKWIQVEYDRINAGPLSPEEANEARNEAKKEIDAHRAGSVWALDIADQDSRAYDRWLAAQYRMIDSRSLPPGEAVAARTEAKRLLDVHRATSVWATAINPLFLFVLSIVVYLVGEEAGRTERHWASLSPAWQSAFSQHEVQLDISQRWNDPNADQALKVVSSDGMILYIPAYMFQSQSVVLREMIKEIGLPTTNDSTPTSADPSKTLSFTDNTLESSSVLHFAVVSRRELVVVEIGEEGNQARESFSHRFSCSRVHSPSSSYANYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRY8</accession>
    <name>A0A1E3IRY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029975.1">
        <property type="nucleotide sequence ID" value="XM_019177936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRY8"/>
    <dbReference type="GeneID" id="30195072"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23662" checksum="0B36783901F2A8F3" modified="2017-01-18" version="1">MSTPTPVTILGSTGLTGSETLHALLTSSHPFSITTATRHPPPHPFPLPQMRTPKRPNSPRRTNLAFALRYSRRYCPKKARTRGRSEKVDWELNRDLATRAKADGARTVSAITSSLAIAIKFHLRREIDDPQAILVSGSHASPDSSVFYLRIKGQLEEHLTTLGFDHVVNLKPGMLLGPRERVDWAEIGLQKLFGWARWAGVGTDALAVDGKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISH9</accession>
    <name>A0A1E3ISH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030114.1">
        <property type="nucleotide sequence ID" value="XM_019178075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISH9"/>
    <dbReference type="GeneID" id="30195220"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="115" mass="12170" checksum="094301C77608B48E" modified="2017-01-18" version="1">MSQPGLPKDEPDTSALPIGDEKDDAKKEDERGKGQGDAKNGKEGPEDDLTGSVASHDSSINSTPRPPIRQDTPWPQTAPDPIVLLAMMANMQPQVVDLLANQKNTPAPAPEPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITW9</accession>
    <name>A0A1E3ITW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PfkB family carbohydrate kinase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030191.1">
        <property type="nucleotide sequence ID" value="XM_019177807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITW9"/>
    <dbReference type="GeneID" id="30194941"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="187"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="45351" checksum="059E5600BB3F92E7" modified="2017-01-18" version="1">MPPVLASIGTVLIDAFDTLPRPVVDDVSPEYSSPTSPGVPQPPISNIPPPLFIPPSHLRLSPSLSSPSASAPSGPSTPQLSLDDIPVPNAEEVYEMLGGGGLFALVGARIWLPPSRLRALANRAPPEEDDCPKDVEDRLNKLGEEMWVWNRGPGVKMTRARIRYEGNVRYFQPIVKAPHWSLTEMCASPLRDSEYLHISPPYSPKDVFDLIEEQKASKGQTWDPKIVFEPTPPSCHAGQREWLEKILPHIHVLSPNHEELFSFYDIPTMSVQSPSLRPTVERLVTFLIHDIGIGADGEGIIVIRCGSLGSCVGTKQGGLKWCPAYWDRENSKRVKDVTGAGNSFLGGYVAGLHLSDNPYEAALYATVSSSYVVEQFGLPSLTGADAVTGEEGWNSDNPSRRLRHLKKRLLAICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU39</accession>
    <name>A0A1E3IU39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 45, member 1/2/4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030243.1">
        <property type="nucleotide sequence ID" value="XM_019177859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU39"/>
    <dbReference type="GeneID" id="30194993"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="752" mass="81480" checksum="F06BE0B1E00B1CAF" modified="2017-01-18" version="1">MTGAAFFPADTEREREDAHPVQWVGTPAVKGPPWARRPLLTVGMLGIQCVWSIEMGYASPYLLELGLSKSFMSLVFMAGPLSGLIVQPLVGIFADRSRSALGRRRPFMLAGCAVCVSAMMLLGWTREIAGFFGAGQWMAIALAVWAIYCVDFSINAVMSTDRALVVDTLPPKEQEEGSAWAGRMFGFGSVAGFWVGTLDLTGTLPWLGKTQLQILSFITSIILMVTHTFTSWAVSERVLLRDDRPQSQSGLKSNLKAIWENMFSLPTGIRTVCLIQFFASLGWFPILFFTTVWVSEIYKASVPSEGIDQAVFESDAVRSGSRALLLQALVNIVTSIGMPFLVSESGIQAEAQTGGQYAPIGLGINGTMSEAPPSSATWKRTRQGFAGSSFTQKTIIRLKDLLDDVKSGEWGLPIKGLTLVRVWWVSQFVFAGAMAASWFVTTVHGAYAVIATTGFCWALSQWAPYSLLGELILIDGTAPRDETIGLAPMASSEVGPLFTLFQAGEEDEEEEDSTPLHRSDISSRSTPLYSRYPSRTSPNPSRGPSAPPSPDEKKPKGHRPQLSLSLQSGLSPLVIQGEQPVEPPLGSTVVLRHSDDFSSSSPTTSPSHLRHNSTSSHFSRAGRDSPEAGAEESTADKAGVILGIHNVFLVLPQFIVTVLSAVIFWLMEPDRTLPVHHPGTVPMTNTTAAAEVEDAVGEILKRGLDAWKREIEPEVSSPDAVGLIFRIGGVSAATGAWICWRMARNWKKGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVR7</accession>
    <name>A0A1E3IVR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_05508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030341.1">
        <property type="nucleotide sequence ID" value="XM_019177590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVR7"/>
    <dbReference type="GeneID" id="30194721"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000004">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1069"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122988" checksum="374B11A68A051FF3" modified="2017-01-18" version="1">MSMLPPRSPSKKSFPGVNTAEKRPASPNTLMSLNSPTLTPKSPKVVLGVCAMDVKARSKAMREILTRLVDIEKGGLEVKIFGDVVILEEDISHWPPVDVLVSFFSTDFPLPKAISYTQIPNRPPPISINSLSMQSLLWDRRLVLAILDHIGVPTPNRAEISRDGGPRIPRPLRRKVRKELGLRKDAIPKDTEIILREDGDAIIVGGHVIEKPFVEKPVDGEDHNVYIYYRGGGGRRLFRKVGNKSSEHDPNIYHPRTIGSFIYEEFINVDNAEDIKVYTIGSNFSHAETRKSPVVDGLVRRNADGKETRFITPLSEAENQCAKDVVEAFGQRVCGFDLLRCGSRSMVIDVNGWSFVKGNQAYYDKAAEILSGVCQLARDRKIRGIQAGLPADNNNNESAGGSTTSTLRATITVLRHADRTPKMKLKFSFPADQAWSKPFLRLLRGHREEIILRDTRQLQFILSAAEESAKMEGITEEQLQKLSQIKEALGRKMNFAGTKAQLKPSFAKKKGEKGEKEGKKDKKDRKEKEDEGDEEDESEEGRRRVNEWLARGERATADGVAPQPSTPDNAAVDVGPRSGVPHSPQITAALDEAPAGGRHVNCQHAEDEPDIPEGLEKMQLVVKWGGESTHSSRYQSRDLGDAFKKDIMIMNKDVLNNVKIYTSSERRVINTAQIFAHALLGAEGSSSTSQQVSSGNGQSSIAASRLPPDAGPAGPQISHLIQRRDLLDDNNAAKTLTSDAKKKLKMLLRTGETERRTDLAWPKSFKKEPVEVVSDVIEQLTELRGIMRRNYENGNVEKIPQQRWCSGDSPWLFKERWEKIFDDWVGVKQEKFDPSRVSELYDSIKYDSLHNRTFLFAVFDPEGKGQTSKAGAPNQDRRLHDLFGRAKALFDLVAPQEYGFDAEAKEEIGVLTSLPLLRKVWEDLEEAKSTGKSLACFYFTKESHITTFVHLLLASGLPFTNVRIPELDYCSHCTIELWEKSTGTGQKDFSIRLSISEGAHSPAVLDSNVDARHSLTVQPRKKLSSHIDYDLAKDCFSKHFNRGLSFSTTPLEGDEVYLKKSIQDESVLPLSSLHGTASSSRQGDETPRMISSASSDRSHPGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVS3</accession>
    <name>A0A1E3IVS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030347.1">
        <property type="nucleotide sequence ID" value="XM_019177596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVS3"/>
    <dbReference type="GeneID" id="30194727"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130049" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="443" mass="45637" checksum="556E56A13AB89A86" modified="2017-01-18" version="1">MRPSLRFLLATSLLTLPSLAQDDQIECPDTDLTTYLISLIDTLYSNGLTTSEELIVHLSETDAGYELLESLYMADAGTKWTFMAPTDSAWQNAGIYPPFSGMGDEYGADLMALHALQGTYSASSLSTTSGVGIASTYLLLSSELNVTSSNSDAYQAVALNKGDDGEAVIVDGWWGNGTSWSGFVDTSGANGLGNINILPVDTVIAFPPALSEALTTSGLSNISSAIEVVGQTDNLSQLSQHGFTIFAPIDSAWGDDVKGLMGDSNEAGGLVGNHYTTNYTLFSPAWTDDDNKSFDLPVSSGQTLTIKLNDDGGSSVVLGGVQARILKSDVTLANGVMHVIDTVLYQSNSTSSTASDSASGVAAVATDGASGTNPSATNAVSTIDSSGGGVSSSGSASDSATTTELTQAADGQPSSTSSAERLGARKLYMAGVVFLSVLSYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWC0</accession>
    <name>A0A1E3IWC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05645</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030475.1">
        <property type="nucleotide sequence ID" value="XM_019177724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWC0"/>
    <dbReference type="GeneID" id="30194858"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN92848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="730" mass="81856" checksum="8771AE5719E9988B" modified="2017-01-18" version="1">MVRVLHYAILITFSVLAVSLYHIWGYDRAWRTMQSAVNAWQSSQEGTSNPQFMTLPSSLLPAEYQYDLDANAPYPFLDGRHTGYRVHPLPLELAIAHNRSLSASSGAPFWPGNSLDKNTTGKEDGSIWARMEQMDMVLAYDSFAKMLWEGKERRGEYVQRAKIQSNDSPPFEGWNRISGRMRLMSGASGALSMGRRVQYDLLGLHNERDGTCRIYGFPQGRTPDLQHAQRFLERSLKDYGMGKEEAITLSKVEASELPATWLMSRLQEPTPDCPLLAHFTLPPLFSLPEPHAQPLTVHDLNLHNLTTGKAASLGFGGVAVSDGCGWAMGLEGTMAKETLSNWRERKMRSTSAALGMRQPLFPLLGHGIDRKLTKNTSRGMISMMMLVDCFLLVMTTVLGFFDDDWSMPHTWNITAARAASENSRSFHSSPAIFALTYSPPTRNILLVKVTSMLEQMQRWFIGSSSCLSALLGCIAFFSLPVLLRTAILPITAFILYSFWVPQIIRNTYEGSRFSLGWIAIMLKSTVFTLLFLFTFIFPDAGPTMIEYRSWPYGIVAWQVVQITILFAQSMYSPNSRYLPRFLAPKFYSFQRPLTTELRATLNLCDSPTCHICYEAIRFPQPPLDLDNAEKRETGIYIQTEEVVGDDGDHLLPENARSEGEGEGEVVALYEAGEAPAVDDWAVGPCGHVWHMTCLKKWLATSPMCPLCTLEMPPLQGDPDTRPAMEVIIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYD0</accession>
    <name>A0A1E3IYD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030540.1">
        <property type="nucleotide sequence ID" value="XM_019177387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYD0"/>
    <dbReference type="GeneID" id="30194513"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000268">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN93435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="996" mass="108261" checksum="283CD8BCDF338026" modified="2017-01-18" version="1">MSEHEKVGNTEEIPTKESSLENKVEGEAPAAAAAEPKKKREYKEMSHENTGDLHAKVDMNTITFTSADLYDKDKVDIEHVVMEEVLQLLQCTESGLTQAEATDRIGIFGPNKLEEKSENAFLQFLSFMWNPLSWVMEGAALVAIALSNGGGDPPDWQDFVGIVLLLFINSTIGFIEERNAGNAVKALMDSLAPKARVKRDGNWAEIESSELVPGDLVAFKHGDICAADCRLVDAIDVSMDQAALTGESLPVGKKLGDECFSGSTCKQGEAEGIVIATGPNTFFGRAATLVGQDNDQTGHLQMVLARIGTFCLVSIGIFVLLEILILYADFRYSYRRGLNNILVLLIGGIPIAMPTVLSVTLAVGAQQLAKHKAIVTRITAIEELAGVTILCSDKTGTLTTNKLTIDKENVKCYSKWDVEGVCLLAAYASRVENQDAIDGCVVGTLPDPASARAGIDLLDFKPFNPVDKRTEITYRDNHDGGKLKRATKGMTGIIIELCSRGKTNELEDQLEADVEEFARRGLRALAVAYEDVNGSSHEDEGNGFELVGLLSIFDPPRSDTKQTIDDAMALGVKVKMVTGDQLAIAKETGRRLGLGDHMYPAKVLKDGPEAGGKHANLDEMIMDADGFAGVFPEHKFEIVKRIQNLGHLCAMTGDGANDAPALSRANVGIAVEGATDAARGAADIVLTEPGLSTIVHAIHGSRVIFQRMRNYAIYACAVTIRIVVCFAIMAFVWQFDFPSFMVLIIAVLNDGTIMTLSLDRVLPSTTPDSWDLAEVFAYGIGYGFYLSASTIALFAVMNETTWFEDRFGVEAYKDNSYGGHMVIYLQVAIISQALIFVTRSHGPSWTERPSFALMGAFCLAQLVSSIIAGFGDWGFTQVHSISGGWIGIVWIWNIVWYFPLDLVKFAMKKTIIAALQKRKARQTAVATPDEALHRTPSRHESLYSNRTNFLSRAANRLKGGNKISMSQTELQRFSSIQAQQSGAALTRAHSRPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J013</accession>
    <name>A0A1E3J013_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030751.1">
        <property type="nucleotide sequence ID" value="XM_019177170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J013"/>
    <dbReference type="GeneID" id="30194287"/>
    <dbReference type="OrthoDB" id="2571241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="70044" checksum="7F0C4E9C0E470A0F" modified="2017-01-18" version="1">MSPPYIQHLWSTPRSRRQVRYYWPRSNPDFYPGLDGGMGAATQESNPAMGQSTAYSSLTSSKISVSSSMGPPPAGMDPAIQILTAGVQGLVWQPMAKSQPAMQGCEGISTHLWPKVAHQTYAWPVGTVEPVLEHPYMEQEYAETGEQRLSRLSRKRKAWMEGIASFKMYDAPGNIGAASEGWWLWILSQYDTDRRLAISTVVRSCNAFFTDSQMWSTFLNKPMFFSSLLTNTSSDNGTPSLRAAPHILLSILALVTLLQQGHTPEGHTLALLFNREAQSILSYCVQTGSQDPSLMAAAIVIAIFETIPHKGHNDDRLGDALVMLDGIGCIVFSSRLDADDDRVTSDMLGLPRLTWDAATSVNSQKSQGKLEIDATVAIWAQVPGWGENWSPGEMWKEEMRRMCWTASSMAASHSFWKFMVGKKTLDLQISHPERFRLFFPGEMVFLEAGDDKQGKTVSYACEQWLKPCVRHFVTNNRPLEPRYREQIVKELTVIEKDILILNQVGEMKVYLWQSLDWAMVLRRTLGAVDPKTLEKWFQVELKYFLSLLGDRAPVPGVKRRPMVTWWMIIEAYSALEMSRIDKAFWADADKIYHMALDNAQVIIDYWDCERKYLIPEPSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J016</accession>
    <name>A0A1E3J016_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030720.1">
        <property type="nucleotide sequence ID" value="XM_019177139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J016"/>
    <dbReference type="GeneID" id="30194253"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="130" mass="14698" checksum="0629B04CE9FBCCFB" modified="2017-01-18" version="1">MYDGPVRGGTRGGQGDFKWSAVADDKHRENYLGHSVNAPVGRWAKNKDIHWYNRDVDDGDTERAARERAEEIARVKQQEEDALAEALGLPVTKRDPDAIGTGANDVPVKKSEKDEEIERLEKEERKREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J228</accession>
    <name>A0A1E3J228_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030994.1">
        <property type="nucleotide sequence ID" value="XM_019176962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J228"/>
    <dbReference type="GeneID" id="30194070"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="59997" checksum="EC1CE92C2EBDAFE5" modified="2017-01-18" version="1">MSSIELINPKAESIRRTQALQVNTAGAVGLANVVKSNLGPRGTIKMLVDGSGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDEQCGDGTTSVVLLVGELLKQADRYIQEGVHPRVVGDGFDIAKKEALSFLDSFRQTPKLDRANLISVANTSLSTKLHTRLATKLSADVVDAVLAIQPPAPSSENEYREPIDLHMIEIMKMQHKTDTDTTLVRGLVMDHGARHPDMPKRVENAYILTLNVSLEYEKTEVNSGFFYNSAEQREKLVESERRFVDSKLKKIVELKNAVCDVAIGSNEKPKSFVVINQKGIDPMSLDVLAKNGIFALRRAKRRNMERLQFACGGVAQNSVEDLTPDVLGWAGLVYEHTLGEEKYTFVEDVKEPKSVTMLIKGPNAHTMTQIQDALRDGFRSIKNGIEDKALIPGAGAFELACAAHLADNAKTLAKGRAKLGVQAFAEAMLVIPKTLAANGGFDVQDAIVGLQEELAEAGEGGSVGLDLKSGEPMDPVAEGVWDNYRVKRQMLHGAATIAVNLLNVDEVLRAGRSSLKQEGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V9</accession>
    <name>A0A1E3J2V9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17 18">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031167.1">
        <property type="nucleotide sequence ID" value="XM_019176692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V9"/>
    <dbReference type="GeneID" id="30193787"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="14">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="213"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="475" mass="51835" checksum="99BF10EC03C09544" modified="2017-01-18" version="1">MDLVPYMFYEKQEPGSQLCAQHCLNNLLQQHSFDEFGLADVAKELDEAENAKLSVDYRNKKSYNFDDSGYFSISVLERALDVFDLAMVRWRGEAMKAYQEHPEQQVGFILNLASHWFPLRRFAPNPPHAVAIKRWYNLNSFLPNGPEWISPTYLRMVLTQAEEEGYSVFVIRKNSPGGQDSEEPLTGEGAGWADGGIGVLPECLADTMAVTLGEPVGRSGPSSGRSGTIRTGGTDSNQVNGDPNVQPSAGPSSPPARGSGRRRRQPDLSSDGIEPIDDPFSAPPPASRSRQTSSRSQTVQGDGDLFDNVHGVLQEPTNARPDPISIDDSDEQEDEDEELDDDFEMLGAGGAGTYRGPTDFQQHARSYDDEDAALQAALKASMADVPQGWELPDVWKEEKSGTRSGTGGSAPSLATPADSAPAPAHEPAQNWSVRDSEAAPAAQEEKNEVEDDDGDEPAEEVSPEEIRRRRLARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2W0</accession>
    <name>A0A1E3J2W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031162.1">
        <property type="nucleotide sequence ID" value="XM_019176687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2W0"/>
    <dbReference type="GeneID" id="30193782"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="270"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="471"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="694"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1079" mass="125899" checksum="A59128F48A35E482" modified="2017-01-18" version="1">MFPPLSSSSRSTDTAALSASVDLEVIEAIFERGRDATSFPQIFRPYTEVLQESGISPTNDSVYYNFLLKVGVIKAPTWGDKWDVWKAAHSQTLPSFYSQQDSGSYSSGTYTQPSKSYASSQLPEVRKRVPFLASASSDLDEGYTGGEESEVLASRPSPRKSMLQMEMDMEREKSSGRYTPTQVDVTVEEDLMSFDPPIRTSTPIYAQHQHYSRGPPAYTASDISRALEDTADEFSALGLSTPKQSQRDMDAPQTISWVDQIDELSMESRRQMEEKADVFYNYGLMWRCWNMWFKTSEWYRFTYKNITTARNNLLLRQALEKWQHRTRNTLSLPPVADHHHSTTLKKSIFKLWLLRIKQRDLVERETQLVATMEERARKQVWDKWEMRWKKRREDRWRTEMAGKEIGFIQKMRKARLASVFAKWCLASKYNIIHRRHQTSLLANTLTHWRDATLNQRHLNGILGGIQLGQKEEAFQIWRQTTVLRPLERDLVLRNEQRLAGRVMDEWRMSSWQNRQASKLDRRRLLGEALSKWKQVHLKQKSLNRKAQTFSKLCILATTLHTWRLSSREVLFEQIKDRRRVTQAFATWKAGKDRLKGLEALADTFVEGKDKRLVTTALKTWRSKASHLAHLDSLATHFQHGSLKTKCLTKWRSATQTISTNKALADQARGFFVKRSVFGVWKGQWGQIKVDDWVRKREERVMRGVLERWRGMARKYHDLEKRDIVFTKFVDQRTQQASFTKWLNRVIEVKDRELRAARDHDEKLCWDVVATWRERLSRIRADEKRADDAVEIRENEHLRRTFQSWRLVAKRSKRLRLASEQSLIEKDGRLLRNVWEKWWEKKRERDLEDVRREVEFLHENVILFGVMDKWKAATVILPGIQADASRVKKTTWNAWREAFEVKTKAKRLQKERDMRLLYEAFNLWKDSATEKALLKARRARNRSRPSGGHASDPKIGPRRSLPSSSAHHRSGSASTAHRPSLNPPPIPTGRTFQEYNRPASVYSEPVYTRLRDELGLKRNRRVGSEEPVVPPVREGREGTSNRIARGGSVEVAPVPIVEPMERPRSGSEMLRALRGSIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Z7</accession>
    <name>A0A1E3J2Z7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030862.1">
        <property type="nucleotide sequence ID" value="XM_019177281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Z7"/>
    <dbReference type="GeneID" id="30194401"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="250"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="525"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="870" mass="95168" checksum="E3BECDB1B61B9F9F" modified="2017-01-18" version="1">MHVSRADTDPKHSHYDVEINPLVKGKDAKKPRPLLQKIWDQAVNEAQGEVKAALAAGAYDQQKSLYTPKEVPLEGGKLEIVIGLIEDGIVPTDDKRRWKIVIKPADHTQIDLDAVDKYSGGDKQAAKYGDAMLRGIGAVNVLFRQDPAQKYHMAGAAGRKFFSEQNSSLLPSGGVLYQGFQQSYRYTSTGTGGLQLDTAYSAFFQPGLLVEVAPRILGLDGAPGGGRGGARGGRGGPRGGFGGAPGPARPLQELTPINVHKLNGLLRGAKFTVTHRKTERIFSIIKLTTQPSENIKFTLNGKDGKPDRTVSVAQYFAEQYNVKVTRPRLPCVQYGKNYIPMEFVKLLPYNSIPFARQTSDQTAEMIKVTAKPPQQRRDAIMAWRQKLDYDSLPKLKAWGVQVAKEMLTVQARVLNAPSVLYGGNKNLRAAFGSWNMKGVKFTKPGKPLESWAVVSLDQRCTIQDCQEFVRTFTGHLSSYGVPVKTTQPPISHANPHAGGNNFGVKNALSTAAKSAYMIAKKDPQLILVILPSRDTALYESIKTCATEGLHKPVVTQCLQSAKIKSPRGLDQYCGNVAMKVQAKVGGLTHQVDHKIDKTTMMIGADVTHPPAKGGSIPPSIAVSVAAVDGNNNKFKPALRLQGGRVEIIQDFENMITDHIKTFEKNSGAKPQGILFFRDGVSEGQYSHCLDYELRAIKTAASKFPNYKPKVTFVICGKRHAMRFFATSDQDRDRTGNLPPGTVVDKGVTSPALFDFYLQAHAGLQGTAKPTHYVVVADEIGYSADKLQNLVNVLCYSYARATRSVSLVPVAYYADLIAEKARAWIYNDDSETATVPSTTSGSKVQLADFDAYRIAKRFASAPEFENVAWYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3H1</accession>
    <name>A0A1E3J3H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030945.1">
        <property type="nucleotide sequence ID" value="XM_019176913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3H1"/>
    <dbReference type="GeneID" id="30194020"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11011" checksum="A491DF11B5170992" modified="2017-01-18" version="1">MSDSEDLHIPAGVLANAPFSLPNPDETDDLEEGISHERAHIEPRGATPGTPDGYTIQGVIHEIHGRIKADIEDMLADFRGRLKGLRSSAVQVRMETPNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J495</accession>
    <name>A0A1E3J495_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031060.1">
        <property type="nucleotide sequence ID" value="XM_019177028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J495"/>
    <dbReference type="GeneID" id="30194138"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="695" mass="77311" checksum="78A1093DA0B29CD2" modified="2017-01-18" version="1">MAEPSDALLHPKQGEGKDAISQEDISSAIHRMEKHLEDIKHRQSTIKDIVASLSNLAETDLLDPARDYRVLTREAAESTLNIAGRLVSANSKNAVLDNSHRGWNAAQASHWAHQLHQEFDLLEERGMAYHGNGTWAPSEGDYHSVIGSLDELHNGMITKQQADEVGDLESFIDARRFADALRSQVVSEEVFPKLVTRIHKDLSVAHTSKLSGSPSTRKKTALKWDKALSDIEGAKARFDSYPGWVLEEGQDLKVFEDRVEKLHAVLSEPLEKESQLEQCNSLFNDPRPNVSNAIFKGARLGDLGELLDNRSRRVENALLLNRLDSSDAAKNVAEQTSEGVVRTTLGEEDESAAQRDIFSFGAPSNLLTNAQAYDKLSRALGMMVDGFTYEPETTHFRPSIAQSYMRSLVSLRDQVHGKFDSFLIENSEGEFKENTPREELVKAFDHKRNSMTGSADARKAAPKVDTMVENLVHDLHSKIQTAQIGYEAIHTQQGTKQSLVNHYRALSDLSAANALVKEYYPTEVATTKKQKSRQLHERQLDMEKSKATLDLAWEEATRTHDEAQTEGALEHAVSRVTLEDVTEEVEDVPKEVRSKIPDNATAAPWKSSFNWAEDEDEADLTWWLVGESQFRQKTRRLRGETTTPTGSSFAGDDQEGSDPSVTDLSSATGTGGNAWFRPGGLPASKRLFQGLGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4B1</accession>
    <name>A0A1E3J4B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031375.1">
        <property type="nucleotide sequence ID" value="XM_019176447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4B1"/>
    <dbReference type="GeneID" id="30193541"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="83" mass="8991" checksum="CB77BC37BEAB62E1" modified="2017-01-18" version="1">MAKGPTTEGIGLGIMCFAIYAAYALAFFYGGVLVTQGRVDSGTVITVFMSTIIVSFSMAMLCQGATFLRLCFQRSPRCRDEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4W5</accession>
    <name>A0A1E3J4W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_04527</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031573.1">
        <property type="nucleotide sequence ID" value="XM_019176645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4W5"/>
    <dbReference type="GeneID" id="30193740"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="20">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN95908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="847" mass="90733" checksum="BD52C770DFB6F2B1" modified="2017-01-18" version="1">MSTPPFLPLVDPTANALLPSLALIAPLLIPATLLNVVLHDLPTTATYYVQAEKYDGDLITLLDNGAQRIVVSPSQLEALNGAIPKERLILKLSEEELASKKSLAEQVAGLYIVSFTAHTAKSLGLSVDVFLQHPSPNVSELEELIRSARPSSYVLPTEILANHATTTSTHLSIPAAFLAPILSDRPDGLFPSIVASANHSTKPLGLVYSSRESVAEAILTQKGVYQSRKHGLWRKGETSGAVQQLVGLKLDCDADALVFEVVQHGSGFCHLPQTTCFGGLNGVAKLQDTLQARLESAPEGSYTKRLFTDEKLLRSKIMEEAEELCDAESKDEVAFEAADLIYFALTRCISKGVSFTDVEKALDKKSLKVTRRKGDAKPKWENAGEKVVENKEVKSTVPEPSKLPASDEPIRMRTAVLSELPAEEQKKLLLRPVLNSLAMIDKVKPIVERVRKEGDAGLHALTAQFDKADLSSNVQLPPFATPGEDVLPADVREAIDVAYQNVKTFHVAQNEKAPLVVETMPGVTCSRFARPIARVGLYVPGGTAILPSTAIMLGVPAQVAGCKTIVMATPPRPDGTISPEVLYAAKLVGVTCILKAGGAQAVGAMAYGTDEVPKVDKIFGPGNQWVTAAKMLVQNDTEALVAIDMPAGPSEVLVIADHTANPIFVASDLLSQAEHGVDSQVVLVGINLSPSLLKAIEEQIETQANALPRVAIAREAVKKSLIVLVDSQEKAIEFSNEYAPEHLILHLEDAPGAVEFIENAGSVFVGAFSPESCGDYASGTNHTLPTNGFARQFSGVNTLSFQKHITSQFVTGDGLRVLGPTVVRLAEREGLEAHANAVRVRLAELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Q9</accession>
    <name>A0A1E3J6Q9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031796.1">
        <property type="nucleotide sequence ID" value="XM_019176386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Q9"/>
    <dbReference type="GeneID" id="30193478"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="231" mass="25948" checksum="6989EC5F36458D97" modified="2017-01-18" version="1">MPPSSSCVPKRSVPALVQEWVALRQTGAVRDFNQRYRQALEPLELEVDNPACLCVWEAGLKPELRERLLAEMRIQGHHHITVFDDTCALAEEIERSMAYISAAPLRHPPPLQPHLHLSAAYEAPTAQHSLPPSAEVPLAQALRLAWSNQGTRAAPSTRRPEAIPAPEWGARHKREWGDAPRPRHLSDLGRFVREAWELCPYCRDPDHQQNSCEKLKNKKCAHPGTSSLSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Q9</accession>
    <name>A0A1E3J8Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031712.1">
        <property type="nucleotide sequence ID" value="XM_019176302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Q9"/>
    <dbReference type="GeneID" id="30193393"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="748" mass="84471" checksum="F3FD51579D4B8237" modified="2017-01-18" version="1">MAQDDEQVPCVDPDLSITHNAGLVLAKHAYMRQMDVMWQWPNSLNPWHAGAVNSFLSNTALFDKGHPLHPGQYGLTLYLGYDKTNRPRLLFTLKQVEYIQYCIHALRLSNPSWVEYYSKRAELEQDGSEKAMQELEELEEPSYELGQDDWVPIPDMVLPAEWFIKVEEITIPSFFHLTKINKQLDKDSKIAERHERNELPLPDFDPKRFDPILALDVPPTTEEEEIKKKEQRAVQKEQEKQARREKMERDKLAKQGTPAGDATPKAPPSAPEEARAEEKSEAKAADVKPKEDDSQNPAWIKAAEKAATKVLQDFGFGSNTKSDDDSDDGASRDASLDSGDEGEDDEPQKTLTDDQLAERYHFVASQALIIAAEGGLRNALAEVEAEVTPENEQPKEVGRSSFLALAVTRWDQDSKVVLEVGWSAMYWQEVIQPGSQKEGNAKPVFEEIRDQGHYIVEDHRLDKKNTTYPDYRENYLFGESLQVPKAKLKSTIRNKLVEVNTKGGKGSIYVLVHAPKGVDFDFKDIGPSFSTERGDFGDLRPDTGNLPPYMDATNDGADYLYRTLPLFSEVLKEQLPPAHLPVTLPSSTRPLLTSLGRTEKSLQHVAMLLFGDDEHRKPQFCGNAGNDAFYTLQIFLALMTGNTLDKFREVYEANPVQPDFFSSMHDPTAAEEPLELIIPGPTRDQVQDSEKWENDEVEGQSIEEWIANQEDGFQVIMDPNHVEEEELRGVSFFCEDDEGNEVAVGWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8S1</accession>
    <name>A0A1E3J8S1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031870.1">
        <property type="nucleotide sequence ID" value="XM_019175957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8S1"/>
    <dbReference type="GeneID" id="30193044"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="884" mass="97208" checksum="71BB21A90F81E63F" modified="2017-01-18" version="1">MTLSFPVPPSDAQSAPSSPPTKRAKLQNYPTQPRASESSPVSPTTVPSYPSPASMDNLSVPQSESSPTQHQETSGRQFAVPAVRRRESFHFSGERPHPPAAGANHSLSGPMPTVRLLGTPSDKGSPALSSRLPTVDKEELTTKGRKRKRLAKACSACHKNKRRCDGFAPCSNCEFSNRPCQYVNAQGEPIPPPRTRDSSASVPLKKDGSKSGSNETSSISLGHERKASGESSHSQQGMGDPEYEMRRKPSVGPLQIVEMDISLSAELVDIFFKRCLPLPIILHLPTFNYRLYLNQVSPVLLDVIYAFAARLCENPIFLQTLSPNHLPHHRGELFALRAHRNAESLIHQRKKFSEEARRADRGSWQETELAQTAYLLSVYFTCTRQAKLGLFYLEAGIDILRPSPVPYIQPPAAHPGSNPVEFTTHMETRNRTFWALVLHDLCASTNGRPRKLTEADLGTIPLPGSETQWARWGGSGPNGREPGRRDGLVPGTGSWSDEEGSVGEVGHVIRILSILADIMALATDSSSGESKQVFALRLEGALKNWAMSLPRHMHFNESNLTHALGKLASQVPEAKTSGWMYAYMHAAAECGMFYLQAAVAPASDSVVTARRQSQAIENLIVIMDTIGLAGREGSCFVFPLFVISNWQDHLEKSEFLIRDVKHHLTEERLNLWWAEKIREWGIDQHEVLQRGFYALPFPSTASSPSFHQTRMPSVETPSSLGLYQTSPRGRASIYSVTAISPSSSAVNSTPLFSGNPRLSLPSLPPFRPRATSGASTMSYHGGRSPSPPHHLPYVNTSSDRERDSVTLPPLSVGLSSFREPPSPRHPLSQSISSRYLPKSHPYVRERSQSPRETGRHGEGMSGIAALVSVAEREREKEIAKEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBW3</accession>
    <name>A0A1E3JBW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032003.1">
        <property type="nucleotide sequence ID" value="XM_019176090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBW3"/>
    <dbReference type="GeneID" id="30193178"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="279" mass="31108" checksum="4780D1599E8322F9" modified="2017-01-18" version="1">MALVDYSSESDSDSRKRPSLTPPPPPKRAKKLPSLPATFDTAPKDDPSLHQGRTRSRPFVDGEYNTHVYLSLAIPPLLLSTLKELLSSFPSATNPLHPLLPDLHISLTRPLPLRRHQTKSFTDDLKVKFAKEVPAFRLSLAGRVKEYFSEVHVENGQGRGFLALRVGAGAAELKKVVDKTLDPLLKISHLPTYHKNPEFHTSFAWTLLGQEETMVLGDALDEEVERPAEKCLISQELLDKINDRFEERLLAAQPTGGWLIDSVELKISKDITTIPLGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC15</accession>
    <name>A0A1E3JC15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032259.1">
        <property type="nucleotide sequence ID" value="XM_019175769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC15"/>
    <dbReference type="GeneID" id="30192854"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="38197" checksum="6EF584ED55EA0404" modified="2017-01-18" version="1">MASAATEPATQGLPPVGEMTSRDYYAHFGIHEEMLKDSVRTLSYRNAIMQNPHLFKDKVVLDVGCGTGILSMFASKAGAKLVIGIDMSNILDQAEKIVRTNGFTEDQIVLCKGKLEDVELPVKEVDIIISEWMGYFLLYESMLDTVLLARDKYLAKDGLLFPDKATIFLAAIEDQDYKEEKIDYWNDVYGFDYSCIKEIALKEPLVDCVELRSVVTNPCAIRHIDIKTVTKEELTFNVPFKLKATRNDYVHAFLGWFDISFSCCHKPVNFSTGPQAKYTHWKQTVFYTPKTLTVSEGDTIEGTLSCAPNGRNPRDLDIIVDYEVVGEEGEKGRMEYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCK5</accession>
    <name>A0A1E3JCK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell cycle checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032287.1">
        <property type="nucleotide sequence ID" value="XM_019175797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCK5"/>
    <dbReference type="GeneID" id="30192882"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN98425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="674" mass="74213" checksum="741C1FA8D567F490" modified="2017-01-18" version="1">MATISSHSVDVDVVEEGVSGTSQMWTELYCPTAESDLAPGKARVQKIKGWLHEALFGYPPEVTKPPPPHLRDKLRKYRRILFLTGPAGAGKTTTLKLLAQQMDVDVDEWGEGVEEWGIGTVGGGGFVLTRDTERESSISKFASFIDRDTSSLSLSSSRTATPQKKARARIILLTALPNLSHPKTMEGFHASLLRFCQRFSTNSCPMVIIHSDAGQSGRAEDSWMDASRDRGGRERGLEILGKGIKDGAWCQEIDFIPIAPTFMFKALFRILTLSPLPTASHPAKATLQLICQSSNGDLRAAINSLQMLCGGRGKIANGRGAARGKGKGRGQKDEGHVLRAVLDAVTRKEQSLNLFHALGKVFYNKRLGDPNQQEDENQETLEMIRQLPKDDDLPSHLKEFTRRKSLVQMETFIPSIPLDASSFALWVHQSLPSFCEEIEQVSQGLDYLVESDAMRTDDDIWQSQPQTIQYALQLTLRGAAMSLPSPVPRGKAAHHKVVKPTFFSEWKKERESLGALESAGRYLERRGVKASNGAVGGTWGGLLSRKEMICEMVPVLIKIQNLSGQPLLPVSAQPATLPNWTPVRTSAASSQSSQSRFTQSADELTAKSELAIEDESLEGVLGDWDEVPGHVVNEEEVTGGEEPKQGIWDDEGIRNEGEEEAQFIEDDDIVDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF93</accession>
    <name>A0A1E3JF93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_03383</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032616.1">
        <property type="nucleotide sequence ID" value="XM_019175513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF93"/>
    <dbReference type="GeneID" id="30192596"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="369"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="585"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN99539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="825" mass="91740" checksum="028A99B2B618E7B2" modified="2017-01-18" version="1">MSEVSSPASSLDFFESDGSDGSDYGAPRRAPVARKPTKKANARSGAGSSASSAPAKKSLKINLTALQRKQAGTNAQAAGDEEVSGDEDEAFDGLVGSRGVDFSNQELKSDHSLRPLWVDDVGNIIVEAFAPFAKQAQDFLVAISEPVSRPSLIHEYRITKPSLHSAMSIGLETGVIIEVLSRLAKTPLSPRLRARIEQWTASFGKVRLVLKDNRYFLETSVPEFLQKLMNDEVIKECMVHREKEMGTTVFGAEEAARPRRDFAIPGTEEARRLERGEAEPEGVRNDDAVLGAVIGIGEADEMDDEDDKVHSFEVSGERMEDVRRRCKDIDLPALEEYDFRNDTVNPNLDIQLKPMTVIRPYQEMSLAKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSALVLCTSAVSVAQWKQQFLHFSNISERQICCFTQGEKEVFSTSAGIVISTYSMIAKTGKRAHDAEKVMQFLRSREWGFLLLDEVHVTPADMFRKCINNFKVHAKLGLTATLVREDDRIGDLGYLIGPKLYEANWMDLAKNGHIATVQCAEVWCPMTPQFYREYLRNPSRKRILLHAMNPNKVQAAQFLINYHESRGDKVIVFSDNVFALEAYAKKLGKSFIHGGTPEGERLRILSRFQHDPQLNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSSKRQGFLIDQGYAFKVITELHGLKEMPNLVFPSVDEQLSLLESVLNQGDAANETADHYMRLNGGKHQKKIAGSQPAGGGTGPTVQRFMAPLEHLSGGQNISYREQNKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHU4</accession>
    <name>A0A1E3JHU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingolipid delta-4 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032568.1">
        <property type="nucleotide sequence ID" value="XM_019175465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHU4"/>
    <dbReference type="GeneID" id="30192548"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="37842" checksum="665DBB253181B0D1" modified="2017-01-18" version="1">MEPVLLPTGPKSHSAPVSRSEKISDGTATPGSASSTSSSALSSADPSDLDAPTEGQHDESGDYAPDFLWMTTEEPHRSRRIAILKAHPEVRKLMGPTWVTVPLVFFILGTQLALSVYLSRFPTISLPVLLTAYVVGGAANQNIFLAIHEITHNLALKSIKANKCLAIIANLTIGVPYAMAFKGYHIEHHKFLGEDGIDTDLPSRFEALVLNNVAGKTFFATFQLLFYAIRPGFIRSQQFTRWHAYNILSVVAFHLAWYHIFGIRPWVYLVLSSFFAGSLHPCAAHFIAEHYLMEGPLPVGEKVEGDDLIKGLAQETTSYYGWLNILCYNASHSFTHMPMHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIK8</accession>
    <name>A0A1E3JIK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03047</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032913.1">
        <property type="nucleotide sequence ID" value="XM_019175181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIK8"/>
    <dbReference type="GeneID" id="30192260"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO00721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="13733" checksum="404250D8B3AD06AF" modified="2017-01-18" version="1">MAGPPTAFSNTHRLYVKSLYKRYLVNSLNWYIRRDLWRERAIEIRAEFERNRNITDPRALAIVLEQAEARLEKEIHPDPYRPPLFPDGTKWERNIPPRMFTAQEKADALAAYNAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW6</accession>
    <name>A0A1E3JIW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle arrest protein BUB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032990.1">
        <property type="nucleotide sequence ID" value="XM_019175258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW6"/>
    <dbReference type="GeneID" id="30192338"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="36840" checksum="4EA183B2613677C7" modified="2017-01-18" version="1">MSAGDLSLQPPIDGISSVSWSLDSQRLLVSSWDGSIQLHDLSGPPQPPRIFSETSAVLTACFGSTSNIGYSAGLDRRIRRWDFDTGLVQVLGKHDDAVQSIVWCAEHHVLVSSSWDSTIKVWDSTLPNPLKSTQTLPARAYNLAYAPLSNRLLVSMSKRHVWVYDVVKLAAATEQIAASQERESALKFMTRSLATMADGKGWASGSLEGRIAVEYLDPADQGSKYAFRAHRQNIDNVDCVYPINAIAYHPIHNTFASGGSDGFISIWDHNAKKRMKLFPKYPAPISALSFSPDGTKLAIGASYEHDNSLTKADEQNTIMLLVKNTVMEDCKPKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJG2</accession>
    <name>A0A1E3JJG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032968.1">
        <property type="nucleotide sequence ID" value="XM_019175236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJG2"/>
    <dbReference type="GeneID" id="30192316"/>
    <dbReference type="OrthoDB" id="10363915at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="963" mass="103184" checksum="3185E19145A43C22" modified="2017-01-18" version="1">MIRYAAAHRTLPESSALAVSHSLNGANTNDKSSGDIPAALVIVGRDLDTTFPTQSPFTSPAPTGSTGSNGLTHTGTIALACVLAIASIISLTFVVWWFLRRKTRKGSMSEEDVESLSPIYAPIVPEVTLFLVPPQMPESRVGRDSPGQDSEGPGQLSPAACGRRGVSPGLPTPPKAVTPGSAITVTRRSYGRAQAHLEPVTEPPETVRATEMPFQPESITKPDFLPSSVTSRLSTIGMPHSPVHKVPFARGFGRIISFDFDSPPVPERVAIRRAPIPSRASSTSRVIRQSSESSSHSVEPIRQISSGKKPYRPTAKRTRRAARNVAKSRPTSRASPHRGKSESVVGGAVQLDLLGASLPNVATPECLDRPPAAVRPLSAPQTVDHAVESSAPEDSGSNTDTDLNYTISSATSVDMPVPSIPRYPYDSQKRERGEDVVELVEVVLTDDESATLEAATPLLEQEDLSAPPPSTDDHDDGEGVVTPVIQDLFMEDDALGLQMLLSPDHIQSAHADALFGPETCVQLQSTFRPVDAVGGLDFSFQQAEGDLLDLLNDMANKSSSRIFTRGSVASTSFSSCQEPLSRMSGDSSLYVAQEKAENDLINLLETIGQPRLPSTRSNMSAAIVSHRAQSSFDAAEESLLYCLEDMCDKVVKSKDNDATEFLPATFAEAEADLLSMLVAMDPSSFALVTQDIMQIPRSGSTGSVPIGVHTPMRGQESLPIEQHRSSVNGKISTASLSRVSDIASAPEQPNIVLGGKQVVGNDTSLTEDFLDIGMELLEDQSEPIPEPSALTSVASPSIAAERRLEQPDLLASARAFLESKRTHHVHVHSKSVGNLSRETSAEDAANVRGDIWQTTPKSSNVLRSPASCYLTITRPSPASLLDKTIRSSQSTPEKQAGEKEVFFASEIGELFGAHGGGQGNLRYRQLHGDVFDELNGGMGNLFGDHESWMGHDQLDYDSDSEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLT6</accession>
    <name>A0A1E3JLT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033076.1">
        <property type="nucleotide sequence ID" value="XM_019174697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLT6"/>
    <dbReference type="GeneID" id="30191764"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO01824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="937" mass="100014" checksum="F7BF8DA5628D408B" modified="2017-01-18" version="1">MGDNPTIRAPSPRKGSIYSITQADFDPPTAPTPTPTATTNVLSAHPHLGHYIFSILNKAYFPPQRSAVGDGKPEKEREKHPLSHSSGGSDDGSDDGANASADIDNEDGDVSQSESEAASQTSTATKSSEEGGSKKATSAEKEELVKRIVDLLDNEQEDELKVVLKPYMGELGKDDILMEQVCLDCMHKRKDDMENLPYAPHLTPTRNRGGPTISRPFTPSRAPSFHGRKPLSRAHSPVLPAGSLKGLSPAPSPLASPRLLNAKASQFNPSARSVSGPGAMNVEAKGFIPSDAWKDAPDTPPRVGSPFGAIGGSGMTRTASNLAIAAPLFGGKGSPFHSPVGTPQLTPVKMPDLFGTASPALSLRSRGVVPDDDDDDEFSPFGSGLPKLHHQENALKPDSKPFNPYFPPSSYLSSDYTPGYPSSAYSDTSFNSAEFGEENGEDVSGAGMTPLDVLCSVFTSVPRNELEDALHRAGYDFEAAMSMLVSQYTAPRSGQSTPQRVSSPRPMGMGRGGRDGFYPNLPSRTLRSMSPMGPRSPAAGGGGGKMCRYFLAGECRRSDCRFSHDLDRAMCRFWLRGHCAKGPNCEFLHQFPNNLDVSALQTSLQRVEMNDYARPDSPGYGQGHLHHQQAPDEFPDLNSSRMTRAPRFDPSRNRFANALKRAAPVMPRDHATAPAPPAPSSVYSDDSAGVAIVPKASSRVALRKPVLLPTLPTGAVANETYLSSRAGSIRLGHARNACLARAADAFRRGDGGAAKRFSREGKALNQRMLNEQAEAAQELIKVRTALAREAIMARPLSWSTDPADARERGKPCGGGLGVVLGVASVASLAGNARGSKGGGGKGGLEEGERVECVLDLHTLHGQEGVEICGQFLAELERERFRGLAYIVIGSEKHVGTQDPNRGASKTRLGTSVMQALVQWGYAWSEDVGIICCDPCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLX8</accession>
    <name>A0A1E3JLX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033117.1">
        <property type="nucleotide sequence ID" value="XM_019174738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLX8"/>
    <dbReference type="GeneID" id="30191806"/>
    <dbReference type="OrthoDB" id="2572507at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="80" mass="8850" checksum="B3A781FDCB614D63" modified="2017-01-18" version="1">MSSYPPTNTFNNVQPALQENPYVQKQPMTQPSMDAQQVPAGSNQEDEEVMRLRGGCPGHFCGLPILPCRINICIFPIPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM78</accession>
    <name>A0A1E3JM78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033231.1">
        <property type="nucleotide sequence ID" value="XM_019174852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM78"/>
    <dbReference type="GeneID" id="30191923"/>
    <dbReference type="OrthoDB" id="2576160at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1222" mass="131012" checksum="EA607D76B2C50309" modified="2017-01-18" version="1">METNPFLPPTADPLSHPVQEDGGQSTQWPLTLSTDTSLLTLKEAARNSSRRRNDTRLPSAGTSPHAPLSQRISKPRLPLADRIGKNKPVYIDREEGEISDEEDGQESVERHEGKNLAQRLGQFSAASSLSASGGTQPHASAAPSRSHAGVSLLERLERLSSPRKRTSQQQMSPLASPPPPSPPLPHIPSTPETEISRPASPEFPPTPPMPATAEPATPPFPPISDWLPSTPPRPPTPMLDAGMEVDTPPLPSPPRVPDSRPPSPSDPPPVEEERPCTPPIPQRNEPLEMDDPVEVYRERLSRSAGAVTAGELMTHPLTPPIPPASPDIDLDIAPVDMPEQSQTMAEAVQPDEPLQISNEEEARVDAGKEESPDEEANSSAEQPPSTAAASDAIPEDTTDYMGLIRGLILDGVSPQQLIERGASAHSVMVVCQEIVERTKQSAGSVEQGSAEEAAFLAVEEEAPHAEGSESRPIYVASSSAASSPTLAHLVHPQPSPLGASQLKEALDLTLPAKPVARLVPQESFRPKQPSPAPAEILPPALSVPDVPPASSSKLDTSIPDASSNLPPRAGSPPPNVPSPNVPVSPASNQTSKKKKKDKKTKREKAAENAANKRKEAPVTRRATGAVVSMTPEDIALHVQNRHEHNLRFHAAMMAGQLPPRPGAYTAYSIHDYPVPSFNPDMPPHLHPYRPAALGPDIRPVEPPGAPPPPPDHPPPDASAAALHARKRMALESMRRKKPASAQSEVEVDTVRPTVDSSQSQSQSREAEAYEQAAALEKEFFNAYISGQGPAGAPPDVPGNVHEKKNGSESMDMELEEPEEGEIAAPPPVLPVIAMSESMTPAEHIPGAPTAARRGTKRPHAEDLMDVRPHSAPPARRPTAPRRLFGLPLNPTRLLLHVDDDSDSDSDDEMEELQKREEERQREADEKQKRLNENILRLKAEIAMKKRRKLAGDTSGAASPTTGDATPTLGAGVVQNLTETAEASGKRVGIDKLASAGTAALSVPEDTRARSSTPADIKQLTVELAQVEAQKEEQAKEIMSANALKSAEEPIIADDDIQVDEEVVVGQAKDAIQPSQPSTQPATSHKSKNFQAYYPILTHYPQLPSAISLHTSPHTPAPDPFAQINRVLLDSIILTNRSQAGSVTLCRAEAGGGKYDDVVEYVYEAYIIPQGKASGREKQGVADIVAAARRQVVSGQTIPTHTIRTDDDTLKQLFEKVGQLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM84</accession>
    <name>A0A1E3JM84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033222.1">
        <property type="nucleotide sequence ID" value="XM_019174843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM84"/>
    <dbReference type="GeneID" id="30191914"/>
    <dbReference type="OrthoDB" id="2575033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1274" mass="136455" checksum="C72C452E58D91CC8" modified="2017-01-18" version="1">MATPQTPKTPTRSLSPITELTTPNSYRTLIFPSIDGDDDARSFQSKDSGDTVKLSQSEHLQPLGKSIQSFATKAPLPQKPSPTAALSPITTSQSPAKRERRRSGIPIKVGSPQQPASSTVPFPTRTPPGPPGPGGLLPPPRSVSNGKPVATRIPISPSSPSSPSSPSSPYGSVSDEARRRYIERYYPNSKEAIARREQNAKIKAAEEAAALEKEKAAQEKKAKDEQIGKELKERRRSIKFDDDTKIEVKPEPKPKPEPESEPAAGQDVVTEPVSDEAAKNMAGVGASDFSVRQRRLSRPNSMYATPPTSRAPSPLKGSYSDVSLADLHRRPAFESSVNRRPSFTAVENGHPTLHNIPVFQEDVYLEMGARRRGWSPKASQQSLPLSTARPRPPTAGPVKKRPHSFGIFRPSTSMQRSRSYSGTPSEPVTPAIETPPATAAATPIASPVNKHQRQKSFSTDNIPAPPSPLRAHQEPAPAAPTASVPAPAPGTVSTTASTRSSVDKGDKNPAGLTRASSILSSIFGSKPSATSLEPKASRKEPPRKRLSKKVPKRGDSGASPTQSPNPRSPLPLLGDLTPEDRSGATTPLASRTSGIFGIRDDGSDVFRLPQDADNKTPSPAFDPRSIRSLQERAGSPHTQSDRVKRVLYVENHVPSPNDPQEGTQDEQLPLPEITTSTTVEEEFHTPISPGSPLWTREPESFGNTLVDLPQEAVAQSPQQTVHQSLDTPSFPPAVTMIDGQPIPQSGSSGHSSSDHGHGQAGSFSPQRALSTPSPDSQKYSESYTTPVMVDEATQTSVQPSPVSPPRPSRPLPRPPSRQTSISPPSYLSPPRPTFIPPPPPSSSPTADLPLLIASHLLSTHAATLLRHSGEIIGTGDVMRKMARESLEWGGILMGMAEKATRHQQEAQRSEGMPRPRSRTPLAFDTLIRSGSHSSQGHASLTRSQSHSVDPARSSYASLTSIPSPTPAVRRVSFKDKEGRSRTESTPRESLDEAQKLGQQGLVNVHAAEEAWTIAMKHLAHAVEDSMSGAGVQEERKEASEQTAGTNEWSENATAASGAPELQNPTRSSVLSYPLGSDGGVSQPASPYSQPGASYPGIDQQTSFLNMASSPESDIFTQAERDASVKRRRMTIQGTSYSSNSHAYANPANRPVGSSQRCVSAAAAPSAGPGYTDEQLQLDSTLPGPPSSLRRANTLAVHSPGARRVMQVSDETQKAFASAGSQGTNSTLTKGSGRKLVKKEKENRVQSEEPGLTDRNSMIGKKKHWWSRRGSIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMH6</accession>
    <name>A0A1E3JMH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033331.1">
        <property type="nucleotide sequence ID" value="XM_019174952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMH6"/>
    <dbReference type="GeneID" id="30192023"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO02079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="400" mass="43366" checksum="03A34B65C3A93E6B" modified="2017-01-18" version="1">MSHSSSNSLLQQARPTDLLPQLPDPAVAVSHAQAHWLESHERTQQQLCKSRSGDCLALDVTVDLAPASYSSSPISSTFQPIASSSTGLRYLNVEPLACPSTDHATADAPSPVSPTADNKASCASLLASAQVSAIGEAMSKDKWQPDASSALCTFPLCTANFAHSSYFFLGPRRHHCRMCGQLFCGNHSSQRALLIHTAGSARSLAQSRVCDMCVPKPGLDADEAVPELSTRKNSATDSEPFSDYSSHSNFLQTPDDDASIFMRSVHSPALSVEVEEELAPIADWMDRSGVLSLYPLAVNPSHSRSKRSSSPAPSAPPLFAPSLKLRRAAKEKEIQRQTLRQRRSGKDDFWLPKWVPQSAEADEDEEEATMTVQTVGGVVEDGPFRYRPRVQTPLLTPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP18</accession>
    <name>A0A1E3JP18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033129.1">
        <property type="nucleotide sequence ID" value="XM_019174750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP18"/>
    <dbReference type="GeneID" id="30191818"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="26165" checksum="86229FE8A863542C" modified="2017-01-18" version="1">MDSTAPTPKRAKTAEEQDQQMPSPATLKRSHDRQLHDGLSDGSLDTLLSLGTCSRTPSQSETPFSASSSGVPRSRLLELTDTTFENSPAISTVLSILKDEQYTLSRLIASAGAKTTLILWHVLLFAKKWEMRYLKFRLQEWICEVAIESYKASMTFFELAAMLAEPMEDAYSLWGVKHEHALDAMKWTKKAWVEWTPEWLYALQHASARWPGAGDKQNRAAGFIRLLQQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRD0</accession>
    <name>A0A1E3JRD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033434.1">
        <property type="nucleotide sequence ID" value="XM_019174382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRD0"/>
    <dbReference type="GeneID" id="30191443"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="47751" checksum="19B5F6CF14A39FA3" modified="2017-01-18" version="1">MAPQRPPWIVNDVTKILGLDEETVAQMIMPQLEESLLGPTQAARDFTTRYLALRFPSISNTASALPNTKLAPDADIAKSKGKAKSPVPGSSSGAGSSRAVQDAFGPGGNVYMKNRDVDDAFFLSRGGSGSQGGISRSGSSTPVPRQAGAVHYNVVDKGKGSAGGAKGKGKAAEKIWDLPKSREVKKIESIIQALQKIKDDGPQPGDGHNCFCQARIHPLSKYTPVCPNCALIVCSLHAPQLPCPSCAKPLYSSAQLTRLLLTVENDLDEQLLKEKGEEEERERKRQEVLMAESGGGNFPTLPVGLTGTNNVPLGNSRKVISIGAKEKGKGRATVTTTTYRSGASSTAPLPRSKSPPPQNIIPRPRSLPTDQNKAASEIAKITKWRKEEGRPWGDLKAEKKGLALKYKEVDRVALRLVDENAVGRRKKGKMKGEGEGGRVVPGAQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRJ3</accession>
    <name>A0A1E3JRJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033516.1">
        <property type="nucleotide sequence ID" value="XM_019174464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRJ3"/>
    <dbReference type="GeneID" id="30191525"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000063">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="393"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="600"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="938" mass="103468" checksum="1596DF10B9C267DF" modified="2017-01-18" version="1">MSFNNGYGQMPGMGFGGNGGNFGGGGFGGGYGGNFGSPGGRGRGRRDNNRGGGRGRGGGGHGGGRPPVPETSDNRLRKMVIKLGDDEDFDPIEDPARLSKVLKRGWQEGTVGVLEGFRVSVTQQPHKHGYYVGLLSALARPSESTHTATTEEDKSIDEDKTPAEPAYGKEILDDLNRAFRGWVEAREWQNVRLCLQFFSLLLPAQLVTPASLYSVYSTLLNVIDEVGGGGDRSERAVRAVGEGIIRSGSALAEGDATQVDALVSRIEGFILGRRNESKPLRSPVAPIVAAGQEQPQYSDVLDNLLAALHAFQASNWASPKIVPSYMREIVLLPGAAPAAYELQDVSMPPELYEEDADNAEAGEGHIGVLNFFADDVSTIFLEARSADSTKIVPSPGSVDGWSLRSLVLDIINLFEVNRKEASHILLDLRKFLPRDTFKPAAQPADAPPPVSTWSLESLIISCLLNAMLLLPKSQHKLVYYGSVIAELCKASPNTVAPPVGRAMRKIYSLLGSEGLDVEIVRRIADWFALHLSNFGFQWMWKEWVADLDLPLTHPKRAFMRRVVELEIRLAYYDRILDTLPEPMTAENAGVIASEAPDPFWAYEKDDHPLHTEATGLLSQMRQKLPSAGIIKYINELPDASSGPTEPLFPATRTMAFETILQLGSRSFSHFLNATERYSDVLRFLTPDFESRRILLNAVKSYWRRSSEMRLVTIDKYLQYGILEGADVVEWIFTDDDAEGEEGAGWTDGDNWEVLAMTLDKQVGRAKAIRRKLRAVEREDESARARRAADKLEQDEDVEADEMAEDARPETSKEARDAQTSLDVQTSRLEKLLNKTFKHFIAALLPWTAADQDEGAAGNVNEGLKGVLTLLDSDEEGLWGVRAKWGWYREFVRKYQSHLLPLAETIDSANFATLTRADDGSAESRAEKMTRGVWEVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWM6</accession>
    <name>A0A1E3JWM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033858.1">
        <property type="nucleotide sequence ID" value="XM_019174051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWM6"/>
    <dbReference type="GeneID" id="30191105"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="639"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="726" mass="78668" checksum="6FFA7C28D7160CCA" modified="2017-01-18" version="1">MPALDPSSVVAVLSVDFQSLDEPLISSIVFDYAPEELADKLDEIRDQLGILEASMVPDTGELGDALEESWGGNRQSASKELAEDLADLDERVGRMNVAWDNEQSGDSTSTGSWNTKTKSSTLGSWSQSTSESQDREIGEGASDWGSDASFDTEIGLLKVLFPNMPVTEVEEALATQAGLEAAIDYLLSIDLIRQDDEHGWPGEPLDREEEPFVPVIPKAKKKKKGKGHGSTASTSSSSMSINVVPSGGTNKGANPFTKTKLRPPTSMAYSFSIAPSQPRPNRGAKSPHSSAFSIATFLRDCVPSQPVDHFLDFFTNSEYATVYSSARASLEALPKHPASPSSPSTDKQYIETRTVLEAMYDVDLGGFNNPWNVSVEEREKFNDLAVCIKVSGLDVSRIIDLMDFLQSLREFQAQEDKAEFVGEQYDAGDLPSDDTRGEDGQESGKDANWAKPPVIAPKLAKSVLPGPVARPPPKTAKARKERHIPGAVPSNVPNATDDFGVASPSPGLIRLAPAGGIHPENWQTAAGEKKAKAKHSAISASARPTVQSQGTEYNNSVRQVQIERAKQMTAIRAAGRSFVSGNKAMKRSVMGHYAREAREAGDRIRAIELRNAHQAVAIQHSNSARPTTRNGDRNRNRVIDLHHLYVHEAVAVALENVGKWWTEEKQLRSQRTGAHGRMMIIVGAGNHSVNKVAVIGPAVGKALDEDGWKVNKGETGRGYLLVHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX77</accession>
    <name>A0A1E3JX77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034100.1">
        <property type="nucleotide sequence ID" value="XM_019174293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX77"/>
    <dbReference type="GeneID" id="30191351"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="107207" checksum="E040C150BFBA4F2F" modified="2017-01-18" version="1">MAKDAYVALRAPLPPPLESLEHARPHFTTLLTSPSSSQNTRLLLKALDGVQEAVHAFLKHKKSRKKKDGDGSGEAEQVKVDWLDTEGVQLWNLASQVGRTTPVNPTLSKADIAIVAACKLTGYRILEAATDTKGPMAFVVRLLGLTAKTMSALLDAGKTAVASQLAVQGAEFEQTLLSATDPQDSGEIKQQVSSLVWFYCARIDLLLKEGNDTFAFDIFLKAIALDEMWSLTPQEATAKCWTVGNTMLQNKTNLPLSIDWLKQGIMLVEKMVNRGLVVDRLEELHLTYCIARAQMMQAEETPQSLQAATATLNELAQLVGEEDQITLREMRVLQLHVLKRSKAPENEVKLVLEDLMKMQEWTEEKVIETLSQLASLMSDYPTLPSTSAQTFLRKALSHPDGHPHVQLIIYEGLLFAKSLSPPALGIRTAVAMLDIARKHGEYRMEDKVNVVACQTLLWNIANFNGNKERITESAHWYQLAGHDLFRELGGENTSRCLRKAALCHIKTADWGAAHDLIARCPTDEASTHYLTFLAAIRQGEVDRQQAAIDAVSSIVECSDFEAQQLVLMTHHYRSLANEKGAQPVLLASMRALLSVLTDSEMSFEVQIETITVIRCLVRMSVLELAQAEDKERVVDSILEYLQTAVELLTEDPSIGQGQTKGIAWLYKCAFNVAVQGLHSLSSKSLADLFDRSAQLMTIYEVIEPMSTDPDLPFVRGSAMFACLCGKIFLCKDLPTGPDKILLLDQLLEYIPQCRNALQGATNTAHPRYSSVSDMLRIIDTSEVELQCEAREWTAIPEILERLKDASKDREVGTTHRTLEMIANVLVSTVTYRLLEIILDICPTRYADDIKRFSRWMRAILRILLHRSGADDESAAFSYVSRALDVLKTPLGKTAYPLDEAHWLVATAWNRGLEWFSSSRVQQAKQWCEAAMTMSSFSPDLKVDRQKMHEHYQHLLDKMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXD2</accession>
    <name>A0A1E3JXD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034071.1">
        <property type="nucleotide sequence ID" value="XM_019174264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXD2"/>
    <dbReference type="GeneID" id="30191322"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="171" mass="19244" checksum="63C478C3DEB3184F" modified="2017-01-18" version="1">MTAPTDTEERVSTTDYHGSTDLSGFFSATHWTQYKLSIKGQQTRKTFVATDQDKEAFRSGISSVMQIPLDDVSVEVLSSYDADFQQGRWNSTYFGHEETARRRTSLCSLSPHALDTSSDRLCPYGSIPEELVAHIQAERDQIELMREEFEETMTTGTEDVSNNGQLDAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYX4</accession>
    <name>A0A1E3JYX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034204.1">
        <property type="nucleotide sequence ID" value="XM_019173499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYX4"/>
    <dbReference type="GeneID" id="30190549"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000007">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44020" checksum="461EA15A3FD1F32D" modified="2017-01-18" version="1">MDSLLAEISKQKRALQSDGADEGPAKKYMRRADVERAKEEEEQRRKELAKQEEERKKEILQAEKAKRAEARRSALGKLNPASPAPSSSRNTPDPSLPSEERFNISPEECIRRLRAKGQPIRLFGESDKERRLRLRALELLEERGPSGAQGRNDFKWALEEMESGFDEKGLEKKARELHRLAEERGKLEGSGSAGTPVEGEQEEGKEGKEVEKKKKGVDMGILDLKLIKTDPNKVYPIIYYALKGVLKEWEAWMDNRPEEIRRSTQGKMAAATQVQSAQSLKPLFRSLRSRDLAPDVLRLLAEIVHHMQSRAYQKANDAYLRLSIGNAAWPIGVTSVGIHERSAREKIGQDNIAHVLNDEVSRKYIQAVKRLLTFSQTIRPPADVSQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYZ7</accession>
    <name>A0A1E3JYZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01329</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034198.1">
        <property type="nucleotide sequence ID" value="XM_019173493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYZ7"/>
    <dbReference type="GeneID" id="30190542"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000011">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="15">
        <location>
            <begin position="9"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="16">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO06098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="651" mass="71671" checksum="0CB42B4BEF33F68C" modified="2017-01-18" version="1">MSRSSHTQALLGPELYKKVRETKILVVGAGGIGCELLKNLVLVGFANIEIIDLDTIDLSNLNRQFLFRKPDISKSKSLVAAASARHFNPNSGIKINARHGNVKDSENDLEWIAGFGLVMNALDNMDARRHVNRLCQAANVPLIESGTAGYLGQVTPFIKDTTECFDCVPKPTPKAFPVCTIRSTPSEPIHCIVWGKTYLFGKLFGEDDEDMDTEELDKAKAGGENAEEIENLKKEAAAFRQVRKNLSAEGGPLSVFHKVFKEDIQRLLAMEDMWKKEGRVKPVPLDYDTIMDGSFTVPPLRVAPAAQPANGDKSSGKAKPAALLRDQKELSLKENLELFLDSCKRLSARAVAFPDTPLSFDKDDDDTLDFVLATANLRATAYGIPNKTRFDVKEMAGNIIPAIATTNAIIAGLIVMQSLNLLNRIHSSPNGASSSAPDVPLRNVFLRSEPSKPLGAFIPQHADPSCSVCRDVYVPFKVDLAKCTLGNFVEDVVMGWLNGTEFEKKEDDEEVEWTVFEAGRLLADPDFEDNHERTLEDLDVKRGKILTVRDEDAKYRPIHFCVCEPAANATTPFTLPCAKPTVPLAYVQPEAVRDSSEEPEIIESVPPQTEPKDLPSTTAGVKRPAPDDDQGDEAKKRKITVVDDDDDFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ03</accession>
    <name>A0A1E3JZ03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034153.1">
        <property type="nucleotide sequence ID" value="XM_019173448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ03"/>
    <dbReference type="GeneID" id="30190495"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="779" mass="80881" checksum="D40F45C625E81CD5" modified="2017-01-18" version="1">MSTSENSSPTDFAFEPPALPSAGHPFVSPGTYKADPLRQASYDPSLPTGSFTPAAANPPVGGYFGDTSYQPQPGFGQGQGQGQYGALNSAQSSFSSASGSAAGGSFSSVDLPGPSLPGISKEFSRPSLADTRRPATASAIQTRGQYGDYMIGGGEDPRRLSQRHVQHLSPNEKDEDDEGDSSDTENVSPETVYMPSNNRRASEPHFNLPGNGQNWNQFPPSASHDASGGAFGLPSAPAHVSPMGYLQQQQQQTTHLPPSHFSRPSFSNRPQTSDGLPSYTNTVTLPPASSIARHVPGGGNDSPFFHHPPGIPPPGARGYEGTFPGNKSFAFDGQIRPPVPPAIPGGIRPSYIPPHPHPMLKSDLAPSDQMGYMSLSSGVLPPTSLPSAGGGGGSSGSGQPRKRPRRRYEEIERLYHCGWNGCEKSYGTLNHLNAHVMMQKHGEKRLPSEFKEMRKAWRKKKRDSATATANANYLTQASAWQANQSRLSLSANSSSGESDWDRRDSTSSAFSVGSERAGSFAAQGGMGMPLMGGVPGAGYAGGGGWGVPGVPAGVMQGVPMQGMMQMGPGFGNGVMMDSRPSTAGSMSSAMSVEPGRYAPTPPGSAHGHPLPHPHHQHPHHPHPGHPGVQPTFFVNPPPPQSLPSLSASSTASTPGPTSASASASTSGPGAGAGAIGNRRPSAPNHLLLPDHNLLDGFRVTEDHSTPTAGNPFPAGAGSAPGTRPSSSHGQGQQQQGQQQQQGGEGQGQGQGQGGQGKGFATLNSPVNGSADYGQFAFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ96</accession>
    <name>A0A1E3JZ96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034185.1">
        <property type="nucleotide sequence ID" value="XM_019173480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ96"/>
    <dbReference type="GeneID" id="30190528"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25853" checksum="EB791C303209A333" modified="2017-01-18" version="1">MPKRMPRVYLIRHGETEWSLNGRHTGVTDIPLTAKGEQMVLDMSPRMIGPGKLIQPEHVRNIIISPRARAARTAELLFGEHKPPKANITTDPEVSEWDYGAYEGLLSSEIAAQRPGWSIWNDGCPAGETPGESPQEISDRVDRVIARVRAIHSAHKDDALGSDDANCADVLIFSHGHFSRCFIARWCDLPVQTGYHLCAEPGGLAVLGYQHRSLDEPSLLGLNWYTEDALAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZH1</accession>
    <name>A0A1E3JZH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034286.1">
        <property type="nucleotide sequence ID" value="XM_019173581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZH1"/>
    <dbReference type="GeneID" id="30190631"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60796" checksum="5F1BB5B93F9D2ED4" modified="2017-01-18" version="1">MPAEAKANEKYQAAAAQQPAAVCILKSPVDAIHILEAVRLGIVPRVTRRLTGHERSLIRPGTVWIWEEEETNMRRWTDGRRWGASRVGNGGFLVYNESLQSLSPPHAGGDMPYGDPYYQTPPRRPDSLVKQTYSTSMTHPVTGKVKKFHVVAYASKHKPGGDGTNPLPQPHQLPALRHLQVQSGIWPEWETRREADFTRRAAAAKQALYAASNGVPSNNPATVPAPPAPQQYPTQPVPPTAYPPVYPQDAYHRPMASPGYHQQYMPSPNVVPLEGGMYPPAGKFTQPYQSPRKEPTELFNAGYPPSRAVSQIPTPNAREAAARYHPYGAPPHRSTDRRVSPYPPQAPPPRSTTPVGEYPREADGYGPASWANAPRVSPTQSYSSYNYPRPGEASRPRHFYEPQVAPPYNEHVKSEYGVDPAYGNDPRRYAYEEAEVPRRGPTPYQQSPSSYGQPVPSTEDLGQYPPYGAPRSPRASSSQGYSASGVTLPPLRAAFGEESGHNSAKVSSENRREESERQSQSPTEVGAKPQQRNGWGEDARQLGELGRRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL6</accession>
    <name>A0A1E3JZL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034414.1">
        <property type="nucleotide sequence ID" value="XM_019173709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL6"/>
    <dbReference type="GeneID" id="30190759"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="285" mass="28240" checksum="33083880953E1FD3" modified="2017-01-18" version="1">MASPAPQGDQGDLPAPWIRQYDANYQTFFYVNPTTNPPTTSWTHPSLSEGEVHPEQAQALQESSQVGGGQEESGGEAAKFLNSGSVADPSPGSYQQQGEGQIQGADGQSPQTGDRGIGSMVSGLIGKQNNNQYGQYGQQQYGQQQYGQQQYGQQQYGGYNQGYPQQQQQQSSGGKSKFGLGSGIAAGGAALIAGKLISSAVGGKSHHNSHGGHNMGAPPFMGGGGRMGGMGGLGSLLGGGGGGGMGGMFGGGGGLGGGGMGGGGHHGGGHYGGGGFGGGGGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZV0</accession>
    <name>A0A1E3JZV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01626</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034494.1">
        <property type="nucleotide sequence ID" value="XM_019173789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZV0"/>
    <dbReference type="GeneID" id="30190839"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="25"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="763"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="672"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO06394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="854" mass="93222" checksum="33A43E5DD9BC6911" modified="2017-01-18" version="1">MSMDGDLIALVNKLQDTFNHIGGDSVDLPQIVVVGSQSAGKSSVLETIVGRDFLPRGSGIVTRRPLVLQLIHTPPNSGSGGRSSSEGSTEEGYLPNLDNSPSASAGAGVMRPGGKSMGDGTGAEYAEFLHINKRFTDFEEIRKEIEAETFRVAGQNKGVSKLPINLKIYGPGVLNLTMVDLPGLTKVPVGDQPTDIERQIRNLVVDYISKPNAVILAVSPANVDLANSDSLKLARSVDPRGLRTLGVLTKLDLMDAGTNALDILTGRTYPLKLGFVGCVNRSQQDINQQLPMEEARNKEEEFFRTHPVYRNIAHRCGTKFLAKTLNSVLMNHIREKLPDMKARLNTLMGQTQQELNAFGDATFLGEQHRGSLILKLMTEFSKDFVSSIEGTSLEISTKELSGGARIYYIFNEVFGHALQGIDPAQNLSLADIRTAIRNSTGPRPSLFVPEVAFDLLVKPQIKLLEAPSLRCVELVYEELMKICHNCTSPELQRFPRLLTQLIEAVSELLRERLGPTSEYVSSLVSIQAAYINTNHPDFVAGSAAIAREGSAVQDQQQQVPRLASSDEKSEEESSSEEEDEGDDVVNGYPNHPRSASASVPEIRRPTTASGMKEKTKRQHIRTASGGQHGSQNANALLGATAGGLHAHSISGTSPHGAKETFLNYFFGGPNGNDPLAPHTGQIQRQLGKGQPGHHAGLSPYGQQQRQQGGEREKELLPDYAGAGRRSGRLESSASFDMKSLGKHLEATNGEEIPHLTPREEMETTLIRSLIASYFGITRQTIEDLVPKAIMHLLVNFSRDAIQQRLVTQLYKPDLFANLLFEDEALVSERTRVKALLDAYKEAFKVLSEVSLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZZ3</accession>
    <name>A0A1E3JZZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034476.1">
        <property type="nucleotide sequence ID" value="XM_019173771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZZ3"/>
    <dbReference type="GeneID" id="30190821"/>
    <dbReference type="OrthoDB" id="10321392at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="575" mass="62887" checksum="485363A063A80553" modified="2017-01-18" version="1">MAESPTPPTIHLVFDALTKNLLPDPLLPCLASTLNLYAHLILFSRQLSDDAEQILSIHNQLLRENESRGVQDGEALVGERGCLTEVEGPRVSEVKRRSVEKMFRLSVEIRKHHIARLLSTRGALLSRAHTLIDHYFPDYSLEKKSYKQHAHLHISSMTKPEAKVVAEGREQVLGWVEDAEAVLAADDYEGPLRYDIFIPGQFKASVHAKALAESMCAEAERIIRDAEDIQAILANDGSWDSQAYEAEFKNRGKKKGEDEKKKEKARRRYTLPARSVNRSPAPESTRNPTPSPPRDTSPPAIPLTPPPARHRARESLPRPELHGVHDRGPSPDPTPAHLKSLPRRSFSTGKKTSLRGSSISRVVAQVKAQETPSHAALPRRESGPPRPPINWKVNRERFSYMSSDSEDFSSEKEVAASINPTTSRTTEKASGPQTIESPRFVPSSPPRRVSSSPVPPPTKPAARTIAVKAAPGSSRLSHSNAVAGPSRIPASSLPATANGRAYEPRVSDGQKTTKERDLATPSGTASKAKGSQGANSAEASSKKRIRQSYGFAGPDFTAPVGQERPKKKTKPRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1G4</accession>
    <name>A0A1E3K1G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034387.1">
        <property type="nucleotide sequence ID" value="XM_019173682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1G4"/>
    <dbReference type="GeneID" id="30190732"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="154"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="660" mass="74025" checksum="9D78C11BACB246BF" modified="2017-01-18" version="1">MSTSNPQALASPSSQYSSPPRLLYSGPVPNRDRRASPQPRRGYSPSWPVDSSSPPPLPEWRARRHVPGAFKHYDHHYQEPSRQIQSQMGSDGRPGWRNVISSNDDFPGAYRRLRSPSRGREHFKKDPPVVNLPPDDYLEFAKPTSENKDTLISDKIIPKLLVLDLNGALVYRRRSSGSTPLPRPYLCCFLEYLFLPEPDHADGPRPWEVFVWSSAQPHNVRAMVEACFGQKWIEGIWEDQTETSVDAMKGGEGRLIGVWARDKMGLSGQDYSRKVQTTKNLNLVIDHLNQTTHFNQPLSFSQKTTVLLDDSPLKAVFQPWSQIVIPEFDEQVNLTSRLAAGINPNSRATPDKETAEESQGEMDEVLLAVVGILDELRYVSNVPFWVRSGGLDLALNVDGVEEPTVETLPSHETFQHWYKDKELHAKWVEKGKEALKRKGIEVRHGLVGNAARSPGSPREPRSPRQPYPEPRPTQSDISLSSATSDMPFDKEESAFARRKRLAEERATKEAAGIPLTQKEKKEAKKALSKAHHLFLIGQSLAKSQRAMGDPIHLTGTILPDVSITHTTTLSGDRERFLLVSLLQPTTTQSHIAERGIGRPLTNIISHHPLPLTFLHKGKATTDTTRMDPLYPARGHRQKGTTLIDATGEIIDRLLQMIPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Z1</accession>
    <name>A0A1E3K1Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034627.1">
        <property type="nucleotide sequence ID" value="XM_019172901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Z1"/>
    <dbReference type="GeneID" id="30189942"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130756" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="180" mass="18635" checksum="6FEE2F9FBCE6C2B8" modified="2017-01-18" version="1">MFFSRLITFALVSLSVTTLAIPTSTTNSLLDSERYHEDHRRHHPSSGTNSHASASASGVKRKATQTAVATFAVLGAATDLARCPVEQMACPITSLTESELAAAGDDVPWECISPQEDLYSCGGCATLGTGIDCTAIAGVDSVSCTAGTCLVHSCQSGFLPTSDLQACNVDSNTTDSTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K252</accession>
    <name>A0A1E3K252_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heparinase II/III family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034725.1">
        <property type="nucleotide sequence ID" value="XM_019172999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K252"/>
    <dbReference type="GeneID" id="30190040"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="561"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="829" mass="90020" checksum="20EAB6DF20016119" modified="2017-01-18" version="1">MAHYQQAPYSDSPAYGQNAYQQQGNYGGYSDSPQQGGYNQYSGGHEGPGGYGGASGYEPAKKKRNKWLWIGLPILIIAIIIAAVLGGVLGSRSSSSDDDNSSSSSSDSTGSSNANTGLPSGVTSANTATNTGANGEVYLAVATDSEYMLPVYATGTNTAGYSAPTTVSDAASTDSWPDDPDTVSNSSIRANPRLAPAYKWEALTSGGLIENNPYFNYWNATIVQNASDTLSDDPTPYDIDGGLAGSGVLDVAREIKLKVKNWAYAYKVTNETRYADRVWLELRTAAGNNSDVSFGNETTRWNMQNHALDAAEFCNAFAIGYDWLYDFWTDDQKDAIMWSIINLGLYYGNLALNGSTEASSYNWWAGTGVGNSAVNGNWNCVINAGLTSAAIAIIDRDPTGIAQTVLDLSTADALNNCFTAPYSDGTWSETANYWYFGTTGAAEIVNALESSYGNDRGLLESNSDGWNHTSLFHIYVQGMTSLFNYGDHGPNKYSSTANSLLYWANRFDQPRYALYQRDHYDAPEPWSMFWYNPAFDGTWWDGLPLDHHFDQSEGQWATARSSWADNDGTYWAMKASELTGHQTHGDLDIGDFVIDAMGQRWAGELGSGQYLSDGYFSSEEQNSERWDYYRKATEGQNTLLISEQNQQVSATPTGNWGSSGTAQGPAPSFEIQSDDTAYFWTDMSSAYNYTVKRGIRFVNARKQILLQDDVESVPNLQWRMHTNATVSLSDATATLVLDSETLVASIVQGPSGAAFSTAEPTRASSDPALPTGTINADQENPGVTVLTIDVDDGGSFSLQVLFTPQWGSNFTAVDSVNNVSLDDWSLTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K271</accession>
    <name>A0A1E3K271_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034745.1">
        <property type="nucleotide sequence ID" value="XM_019173019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K271"/>
    <dbReference type="GeneID" id="30190060"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="449" mass="48248" checksum="7DBE72E3DB29D66E" modified="2017-01-18" version="1">MFPSKAPLETPLALSSPFKCPPPKLAVVRDPSIRVRQAVRDNNVSLLARLQYKTDLRNTDKNRLTSLSWAAIEGSLEVFEWLLLDYGHDDQELSRDADNNTILHLLASVPSLSLSPHTHLLLASSLPPRTSPLSLAEQSTISLQMTQSYLTLFPFLLNWSNTGGKTALHVAAQSGNSPFIEFLCDFAGADVDMVDLQGNAPLHYAAAWGHLESVRVLLEKGCQFGAQNFEGFTANDFAYSERVKKGLQDMAREIFDERRMRRKEERERMEREREREGARARSGSQSTSASLGGSSVGVGSYPSNPGRYFEGYTPAPAASVPMSRRGSDQASVTSSIAYTRPSQTSSRYPSIPRLNTSPSAIAPSLPTTSSPLATQPPVPSLAAPPASVTHQASSTPFPARYPTMPGPASVGMVRPSASIGPGLATVPGGSQGAGSIKRANSAQGIGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2B1</accession>
    <name>A0A1E3K2B1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIIE subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034791.1">
        <property type="nucleotide sequence ID" value="XM_019173065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2B1"/>
    <dbReference type="GeneID" id="30190106"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="46242" checksum="4B64FE43C5007165" modified="2017-01-18" version="1">MADLNLSSDEIQKLCSDLVYQVAYSFYDGPYIVLFKMMVHFNVMAEVDLAQRVGLSTNEVRKYMGILLMHRLVKRHVNKEKLPVPEWKRSYGNNNRNNGPPELRTRDVHYWFLDYREFANVTKYRLAMMRKNIDQRIKSEVGHRGYQCPMDGRTYDPLDLSHLFDPVTNSFKCEDCRSELVEHDPTVDVENNSSLQDMMQRFNIATAPIRDALKAVEGLTLPSINIVAWIAQNVKTGVVSVDGKEVGEEGKKFEVVMGAEDDEDKEKLAQAQREQNALPAWYTHSTVTGDATTLGINDRNQKAAVAERARLAAGGTEQTTSDESLAAHYEMLAEGEEEEEDDEEFEETAVVTGETSITPPEPDEATNGASAEGEGKMVTVAGQPKRVEDVTDEDQDLMTTEEYEAYAVAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3U9</accession>
    <name>A0A1E3K3U9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034990.1">
        <property type="nucleotide sequence ID" value="XM_019173264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3U9"/>
    <dbReference type="GeneID" id="30190305"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000028">
        <property type="entry name" value="Hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="33265" checksum="133CDDEC4A96E97A" modified="2017-01-18" version="1">MAKVQVSPFRLALLQLGGLTSSKSSNIASARSAVAAAAASHPKPQLIVLPEIWNSPYAVSSFREYSERVPEVGSKWSEEVKEGGEGETVRALREMARSSGCWLIGGSIPEKDDKTDNIYNTCTVYDPEGTLVATHSKVHLFDIDIPGKQTFKESDTLTGGSHLTTFTTPFGKIGLGICYDIRFPEMTMIAARQGCIAMIYPAAFNTTTGPMHWTLLQRARAVDNQIYVAMCSPARHPDAAYQAYGHSSVVNPVGDVVVEAGHEPETLYADIGNDADPEQLATTRRNIPVTLQRRFDVYPDVAAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K537</accession>
    <name>A0A1E3K537_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_00037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035171.1">
        <property type="nucleotide sequence ID" value="XM_019172229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K537"/>
    <dbReference type="GeneID" id="30189252"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="238"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO08314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="510" mass="57477" checksum="0FECDF526F07611A" modified="2017-01-18" version="1">MSALSPESLRDVILQSLDRSAEIPDSRELAWDGKLLKTAEEQAVVRAALDSLASKEMVEYKQITTTSYSLTEEGDGIVSNGSHEYRVWQVLPVKGQGEPVGVPDLKKLLGDETTKVGQMRAFKNKWIAKDGAGFVRAAEAPVDETLNVIKEIKETGIVPGGEAAAKELQKRKLITPKKHIHYSISKGPQFSTEVKQLETDLTVEMLQSGAWKSSDFKQYNFAATGVPTDGGALHPLLKVREEFQKIFFDMGFTEMPTNRFVESAFWNFDAMFVPQQHPAREMQDTFYVKNPVKALKPDSEYYERVRKIHEEGGFGSIGYRAPFNQDESEKLLLRTHTTAVTTDMLYKLANQPGGFKPAKMFSIDRVFRNETADATHLAEFHQVEGLVADYDITLGHLIAFMQEFFGKTGNTKLRFKPAYNPYTEPSMEVFSWHDGLGKWIEIANSGIFRPEMLEPMGLPKGVRVLGWGMSLERPTMIKYKIQDIRTLVGHKTDLDQVKKRPAVRLEKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K559</accession>
    <name>A0A1E3K559_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavoprotein oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034859.1">
        <property type="nucleotide sequence ID" value="XM_019173133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K559"/>
    <dbReference type="GeneID" id="30190174"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="74"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="31615" checksum="CFAC0BC928DB67C2" modified="2017-01-18" version="1">MTKHQPFKEVEATRPDFHSDVDPSFTKTPNPDFKPGQGLNNLPSAGDFSPTEKGWKSIIPENEAGADVYKMMISAITPRPIAFVSSLGDDGKANLAPISYFNAVSHDPPTIMISIAAGQRSDGLKDTSHNIKDTKEFCVSIISEPFIEAANYTSIDAPPEVDEWALSGLTQRSSETVSPPHVAESAFSMECEVSHWHDLVGSQGKTTSSVILGRIKRFQVREFVVDPEDPMKIRTEQLRPVSRLGGISYSRSTQILELPRPVWKQVQDTPEVKEALEQGAKKQGAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5I5</accession>
    <name>A0A1E3K5I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035178.1">
        <property type="nucleotide sequence ID" value="XM_019172236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5I5"/>
    <dbReference type="GeneID" id="30189260"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="324" mass="35572" checksum="D4FEC10E2D514C84" modified="2017-01-18" version="1">MGDRQQLLDMGFEADRVDWALRATRNAGLQPAMDHLLNNSDKPIPAAATEEVDEDDEDAVKAHIEKLGGTVDDSDAVAKSIKCTECGKTFRSSATASFHAEKSGHDQFEESTEEIKPLTEEEKAAKLKDLREKLAIKRKAQEKESSAADKANEAIRRKAGQDTGKIREDMKIKEMQKDVERKKREKLEDAKARAAIKAQIEADKKERAEKAAREKALRDGTSAPAPAPAAAAPARPASNVKSSENPETRLQVRMHTGGAPITKTFPSESKLREVAEWIASENLAYDVDTVTLSMTFPRKKFTSADMSKTLKENGLTPSAVIMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T4</accession>
    <name>A0A1E3K5T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035367.1">
        <property type="nucleotide sequence ID" value="XM_019172425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T4"/>
    <dbReference type="GeneID" id="30189455"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="466" mass="50014" checksum="2A7F891091193B1F" modified="2017-01-18" version="1">MSVAAQEQPGPSAQHTLPNLADLVKAGTKRTRVVYAGEGASIDDGLARANKIKLATKLGIEYKDVQTLPPILQSQTAGPAGPKRPSQAAIAAPGAAAAGVKLIGGPEARSTSSSGPQAPEPQALVKFRHQQGYAAEGGQAGSRLSQALMRKKEAREIKPEYHPQWKLSRVISGHMGWVRAVAVDPGNQWFATGAGDRVVKIWDLASGELKLSLTGHISTIRGLAVSDRHPYLFSCAEDKMVKCWDLETNKVIRHYHGHYSGVYSLSVHPTLDVLVTAGRDAAVRVWDMRTRANVHTLTGHTSTVADVKTQDSDPQIISGSMDSTVRLWDLAAGKCMQTLTHHKKSVRALAIHPTEYSFASGSAGGNNIKKWKCPEGTFVNNFVGHEAIINTMSVNSEGVLFSGADNGTLTMWDWKTGLPFQHLKDIPQPGSLDAEAGVFCSTFDKTGTRLITGGADKTIKIYSEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K613</accession>
    <name>A0A1E3K613_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035436.1">
        <property type="nucleotide sequence ID" value="XM_019172494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K613"/>
    <dbReference type="GeneID" id="30189524"/>
    <dbReference type="OrthoDB" id="2563927at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="202"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="45746" checksum="4521F0D05E4F4AB8" modified="2017-01-18" version="1">MSEASSVVSSSSTASLSSELEQLIDAAIFSALRTDALHITYWSALGLAFEGLVLGAVLTVSYRYYEHFGRHDSWLTLSAIALGIASCIGQFGLNLWQTYRFIDKAATAFYLVMEKDIYADMVVLLLIGIHNLAGSLFFIRRTIKLVGHSWYIGIPLVAFSVASFGLCLTSVIFGCLIPWDTTKIMSWLSRIDVYVLTWMTMSVISDVSICVAMTWALTRTRRDIEAAASSLWRKLMMLTFETMIPSTTVVFVLLIYGGVENATFGNFTRALAWIVGPLYFLAVVHSLVSRHDVQHLLQDEFQKREEPHELSEDSNGHPFIRSEKERGPIIPTHIAHFATSFGSTPDLLENSAGLLPARHQKMKPRLQNMRPPPSPPRTEAVTVVPVEIDLNEKAKKDLGFADDNEFGIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K668</accession>
    <name>A0A1E3K668_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl isomerase CWC27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035425.1">
        <property type="nucleotide sequence ID" value="XM_019172483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K668"/>
    <dbReference type="GeneID" id="30189513"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="58" mass="6313" checksum="5A822D00E3A7067E" modified="2017-01-18" version="1">MSNLYATEPATNGKVIFDTTAGEIEVELWGKECPKAVKNFLALIMEGQSSSHVRPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6L7</accession>
    <name>A0A1E3K6L7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035501.1">
        <property type="nucleotide sequence ID" value="XM_019172559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6L7"/>
    <dbReference type="GeneID" id="30189591"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="584" mass="64406" checksum="4C70B07628C93969" modified="2017-01-18" version="1">MPPRRNLKRHNEDDARRPNKRAGKNKRNPTYDTYDEALDGGVEQEEKGERYRDGEKSQRFYERAIELYTKAAELQETYDAVYNRARALYTLATDFFLPPSSLPLFRESITLYQKANDLTNSPLLRMDVAFNLSQAFSTLADVLEDLQTDDDTDKDEVVRKLRCDARDTLAEVMDGQEAFLRTVTMQEGGETDEASEEATEELEGCAEGKGMEVDAGSKEDEEGENSATFETHLPTPSTFIDTVVTLMDIHLTLWESVPTPQPPTEDEQIAVRVILDRAAAIAPEERQPELLLLEIKVLLAMDRLIWDAYKGEAKAGSGVERSLEGAVAALGKVLESLTGAAGEDSHLRAEVITTLADTHMTIASRLSFLSTQLPPGPSSLAQDAWLHLTEATTHLSTAADLPTDGNTPRTFKPSIFLSLSKASLARATLSEVNDAAKRNVVQLFDNAATYAGRAGETLGWKFVRIGPAPTSTGGVLSIGGSSIGSSDLPYQAGWESELLGRSITLQQLRVCFYATQTGLIPSESLVKYQEGSTKLLVKLKALPEGERKIGKKDVERWVGEIENEGELGEVEKTWWNELKLELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6P7</accession>
    <name>A0A1E3K6P7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035675.1">
        <property type="nucleotide sequence ID" value="XM_019172733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6P7"/>
    <dbReference type="GeneID" id="30189766"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="25588" checksum="D60F89ABBCD094A9" modified="2017-01-18" version="1">MSTKWVPLEASPDWSKPLGLPASLTFQDLFSLDPDFLTFIPGPHKAVLLLFPSKGKLAEERKKEEENKASGEGVFKGEGVWWIKQTIGNACGSIGLLHSLLNLPEKGPDAVDPSSKLAQFKAESLPLTGLERAKFLDETTFFSDAHTSAAQEGQSSVPTDLENVEEHFIAFVEAINEDGEKRIVELDGGRTGPLDRGVSTNFLPDVAKVVQEKYFDRADGAVNFNMIVLAGKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K771</accession>
    <name>A0A1E3K771_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035700.1">
        <property type="nucleotide sequence ID" value="XM_019172758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K771"/>
    <dbReference type="GeneID" id="30189791"/>
    <dbReference type="OrthoDB" id="2593582at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50159" checksum="14DC1F15521D52EA" modified="2017-01-18" version="1">MPPPRDHRFSQADLDKRYYRRSLGTDFLDFLIALIRLSVTPITFSIRIMRQAVTSPVTVSLIIKVVLALFLAFASAIFSVLVVGAFFWSWSAGGPIEVEGWLFYGSKSHRLPHVTIPIPPKRLIEDLRYDVQVEMELVRPTNGADETDNFMLSLELRGAADPSLVLFSAAQPSLAPGPLATSLLPLPAFPTHLAPPCVIPWPFRSFCPSRLIGYGDTVDKKTRQRRLKAGFVGSARARNVVSLNKNLMEGVVLKPNGPHGPGVGSAFVSIGREDAFADGTGSLRGREIKTTGWIIVRLIPRPAGIRWLITTYPLPPLILLPPISLALTLTSSLGACVMISFFRRPKRHVKTRAKPSRRPLEEKGSPGERDIQRLVEDGKEKKKQGEAERKQWDELERRKLLDEPETATGTESVTSSSFVASETETATVIDLTQSDDEVRDDSSSRTATEGESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7W0</accession>
    <name>A0A1E3K7W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035798.1">
        <property type="nucleotide sequence ID" value="XM_019172856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7W0"/>
    <dbReference type="GeneID" id="30189895"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="321"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="681" mass="73955" checksum="75D8FB1A9F1A6209" modified="2017-01-18" version="1">MTLYTPDRALLLPTFETYRLKSLDPSSNLLSFPLPAPGATQSRMGYNQQHLSFKEVRSRIGWDHLSVDEGGRRGMWVDGEWAVVGLTLGDDLEPTFTKLADLPQPVSSITQQCEFPSILPLSQTRWAIATGSGSLYILQTSSAEESSFTGKLVARYDLVLEGSEGQAVPFLLRAQHQVAEDDVRLLVSRSVQPAEDGSGKSSFSSIQSTPFELLELSLNSTVENGVDDAPGELNVKWALRGKDLPVWCSWYQGADAQGWIVLSEDEFTKAGAAKEETEVERKKRERDEKVSKLGLGATLSAEDRATIEEEKGDAMDVEEEQGVYPYTWTQTPDTLNITIPVPESISRKDIKLALSRSSFSFSLSTLPADISPQLATFLQKSARQFWSEIDQEESSWTFESTTHTITLDLQKVDENVRWPSVFSSPIDEDSDEEEDEVPETFSAAHLASVRQSFSSIQTRSPDEPPLPHPAIPALLREEMDFDLEDGEDFGETEGENGDMGGGGKVGRNVSTGFIRVETGEASWSRGTNSVLSLPLNGSGGEAVIVKQAVDGLVYSPQREGQPSKKPWAHVSTSPALAFVLSSKRDIRLVRHLSPSPSSSSSSSLPVPTTVLAFDSGSSTAGQGNVYTYYPPLDKASAQQGVLSLSGGDRGALLGVGWLKVGGEGVVVGLCEKELVVLRGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH57</accession>
    <name>A0A1E3HH57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_08134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027915.1">
        <property type="nucleotide sequence ID" value="XM_019180105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH57"/>
    <dbReference type="GeneID" id="30197345"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="49729" checksum="164AA250710D6C45" modified="2017-01-18" version="1">MTDTPKEHHVHRDGGWMSSDKRHHHKFLNDTVQHVDQNPKPLHPVLQGFKATVEKSTRLTMLFNLMFQQIPAGKEYLKDPSGENQVRDFDHLLQLLNHVISTAPRWTEAAHKVGIVGVPVNALLDWPMGTSAGFCVFQDPEVNEHLKKILNVWGAFLSSPSSAYVLGTGPHDWLGPIGKPSLMSVANAPLSTSYSFSEFYHSDPSLPHHGYASWDAFFTRRFKDTVRPVASPSDDGVVANACESTFYKVARDIKARDQFWVKGQPYSVLDILAFDPLSSQYIGGTIYQAFLSALSYHRWHAPVSGTVVKAYIIQGTYFSEPLFVDFDQNAKAGGGGKGKEADVHGETTSQEYLSATATRAVIFIEAGDNRLGTVAFLGIGMTEVSTCEITVKEGDRVKKGDQTGQVVPSSMFHFGGSTHCVLFEKGVELEGFPDYTDRNVPVRSKLCHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJD9</accession>
    <name>A0A1E3HJD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027979.1">
        <property type="nucleotide sequence ID" value="XM_019180032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJD9"/>
    <dbReference type="GeneID" id="30197270"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF29">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_6G10230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="38101" checksum="6EE4C3F168278099" modified="2017-01-18" version="1">MTITTTTPARKKITILGSGVTGLTIAMELCKDYEVEILARDMPNDPDSLGWSSPWAGAIWFGLDGSNAWEQAMQRVSYRKFIALAEKEPESSIVKTGFYDYQDKYDKPDETHLWYTDLPGFRYVTGDEDRTKKGITMFYQSIVLNPHKYLPYLRQKLESQGLTFTRHHSSSLSSTHAAHPSDLLINATGNGSKFLIDVNDQNCEMVRGQVMLVKCDAKDVHIRHGDQYTYVLPRGDGTAVLGGIKETSLEPAPQDSLRRDIHKRCHELLPEHIPASFSDLEIIRDQVGFRPQRNGSVRLEAEQKKGFKVVHAYGVSGGGFVYSWGVAAEVAKVVETTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPB3</accession>
    <name>A0A1E3HPB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028083.1">
        <property type="nucleotide sequence ID" value="XM_019179961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPB3"/>
    <dbReference type="GeneID" id="30197199"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="418" mass="43702" checksum="4F3E47D87CEBF292" modified="2017-01-18" version="1">MFLYNVHAPHKTFALTHKANETQPELLRRIYAKSGLGEGERKGVGLVYEFEGGRWSLDDDDDLQILFSRFPPSSTPSVTLHLKAPTAPGQHPHHAQTALGNAPPPAYPTSPSVKSRTTKSKKAKSHAGKEVGVGAGAGAGAGAGAGTGAGAGAGAGAGAGAGAGEKVDAIVARAGTTDGKTPVKHTLKPLSPLSNPHHLGAPIAGGSGPGRVVSSTSHLAPPGAHSHSHAHGQGSKLNGAPSVSGVSTKSRAKSVMSTVSRKSKYGDPYSEDLGVVKRRAWEEFHANNGVRTVMGKVGEISGVRMLLKAGYRHVYVSREFAIRHKLVPKKFGTTGGYAGIRTIGQIPITVGSRTALHAAYLTEEKHFDVVLGRSWMEKMGVKIDPLDQTILTYMDSGEPIECDIVVLRDEKGDIVTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HSN6</accession>
    <name>A0A1E3HSN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide alpha-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028122.1">
        <property type="nucleotide sequence ID" value="XM_019179886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HSN6"/>
    <dbReference type="GeneID" id="30197116"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="50"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="215" mass="24241" checksum="647CB24B64B1A9EB" modified="2017-01-18" version="1">MSLRIPRLPRRPLPPPPIPRSFPRRPFSTPSPTPSAPGAPGPEPTSAYAKFKALSKKYGSYAIGMYFFLSSLDFSASFLLVHAVGAERIEPFLDEGKAWYRSKRYGEEKALRLKAEDERSREEEAREAKKDGKVEKNKWFGRTFWAEVILAYTIHKTLLLPFRAGLTVAWTPKFVGWLTKQGWVGKGGLTRAATHAQGKVKNASVKVKDRVKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV20</accession>
    <name>A0A1E3HV20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028197.1">
        <property type="nucleotide sequence ID" value="XM_019179830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV20"/>
    <dbReference type="GeneID" id="30197060"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="161" mass="17705" checksum="691FBAF4AA85C14C" modified="2017-01-18" version="1">MPPQGFTECDAPYLASSFPPFAPVVIFRLPPPWAGHEFYTLCSVRLASLADVFEVLVSRATRNRRDPLATPFAASPAASKPHAPILSSLLKDRPKLLASVEKSSRAVRSFESTEALRRMWCARETWAEDRYELLLDEGDVKAAVNVLTSSDLGSFGPVTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HWP7</accession>
    <name>A0A1E3HWP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028201.1">
        <property type="nucleotide sequence ID" value="XM_019179834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HWP7"/>
    <dbReference type="GeneID" id="30197064"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="169" mass="19117" checksum="48151049BB978DAC" modified="2017-01-18" version="1">MPLRQYQSRHSDAQKPREGRGGLLKCSKLKTKQEQEHEHEHEHEHEHEHEHDKEKGGRWKVGSLVNARPWPGAEFAAAAAAEGERTLKTAANEDDGGSKVEDEDNYEQYEDEEGRLPPWVCLKAAVKLGSGLILRLWRDVRLVSGWDKVNGCVDLRIKGFITFVIATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5X7</accession>
    <name>A0A1E3I5X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028347.1">
        <property type="nucleotide sequence ID" value="XM_019179659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5X7"/>
    <dbReference type="GeneID" id="30196882"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129575" evidence="7">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN83775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="370" mass="40729" checksum="2FC4963E6620D5E7" modified="2017-01-18" version="1">MLPGPLLCIISLVLLSGCMAAESLYSVLGVKKGASDGDLKKAYRKLSKKLHPDINPDEAAHERFIEVAKAYEVLSDSEKRSIYDKHGEQGLKQHEAQKAGGAQDPFARFFGGGGVQEQRGPGMITNLEVSLNDMYTGRTVEFQIPRRVICPHCHGSGAETEQDIHQCNHCNGQGVTVQRHQVFPGMFTNVQMACPHCAGKGKRITKQCHVCSSAKTIQTQHTMAINIPAGAPEGFEEVFHGEADEQIGMDAGDVVVRVRSRMGEGEGFWRRKENGILGRVTLSAAEALLGFRRELQHLDGRKIIVSRTGTTQPAEVEVIEGEGMSGYMDIPQGDMFIEYSVVFPTEVSKETRQKLQEVLKYTPPVEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB29</accession>
    <name>A0A1E3IB29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028529.1">
        <property type="nucleotide sequence ID" value="XM_019179491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB29"/>
    <dbReference type="GeneID" id="30196708"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="674" mass="71915" checksum="8732FC3AD1F2FFFB" modified="2017-01-18" version="1">MSTAVGNILPQGAGYGVVIGMGLFFSVLMVSITKLQTRYTSHKTSSAEEFNSASRSVPPGLIAAGIVSAWTWAATAYRYGVSGPWWYASGAGIQVLLFAMLASKLKQHAPFCHTYLEIIQARWGTAAHLVFMFFAFATNIIVSTMLILGGSATVTSLTGMNTVAACFLIPLGVSIYVLTGGMRATLIADYSHTLVLYCILISFGLVAYATSPIIGSPSKMWEMLQTASTNNPIDGNAQGSYLTMRSRSGIIFGVLNIVGNFGTVFNDQAYWQRAIASDPRTSVKAFLMGGVSWFGIPLSIATSLGLAAIVLAHGDNPVITLTSDEVGAGLPAVKAAAALMGKSGATAMLILLFLAVTSAASAEQIAVSSLLTYDVYGTYINKNPSEKQILWVSHLCIISYAIFMGAIATAFFYIGVSMGYLYELMGCIIGSAVVPIALCITWKKTNGMGACVGAVLGFAAGVSGWLGITAHLNDGVINVTTTFGDYEMLTGNLLSIGVGGIITVIWSLVKPADFDWDITRAINQKEDFTLTENDKAPTPPAFESEKEGGQKEGAEAAYQQGGEGYGAGLEATRTRTVEEQLTDMALEQQELQQAFRFAALTALSLVFILIIAIPLPLFFSSYVWPVHGFTAWVVITLLWLFGGLFMVGIFPMWEARKGLIKVAGGIWRDITRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICH4</accession>
    <name>A0A1E3ICH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha 1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028687.1">
        <property type="nucleotide sequence ID" value="XM_019179331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICH4"/>
    <dbReference type="GeneID" id="30196539"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN86310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63302" checksum="111F75F94C12152E" modified="2017-01-18" version="1">MPLAATTRERLEVWRNAPGGRGEVEGEVEMGGFMGWNLEECSTISEQHNTHMIQHSANAWSSLNRSSIHTHRSELISHLETLLDAGRMDDYGEGRGVVMVAGNADTLMRVKWSLEMMRSYGSTLPVLIYHFPEEAPAEDDPIRKTLANLSAHLVPVPGQTKDAHKPKSYHLKALAITSCPFRHVLYLDSDSIPTRDPEYMFEAPNYKRLGVWMTPDYWKTGANNPIWAILGVKCRNEWEMETGQMFVDKKRHLDVFLLWFTFSDGDKDIFRWALLALRKRWAIPGRWVGAAALPSGTASGDFCAHTMLQHDSWGAPLFVHYNLLKQIPSGVGRGFSWGRTKQLPLFNTWPATPGTARLGEPGVKPDDGGERGLGDEDCDMLADAGEDGRARARGKEMVMRRAARERGVRVRYHGGWISALCIDLEYIDPRPQERQDEDDEAREAREAIAAAAAAAAAESESAAPEAPEARDTKDEDGSRPHSRSASDSSDSSGSEKKDGEHAEGAEAGGEEEKKKKQEEEPLWEGVVYPDWRQSPIEVVQWRDDEHLKTFEKTLYDFGFKPSGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE20</accession>
    <name>A0A1E3IE20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028801.1">
        <property type="nucleotide sequence ID" value="XM_019179184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE20"/>
    <dbReference type="GeneID" id="30196382"/>
    <dbReference type="OrthoDB" id="2563778at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN86809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48921" checksum="B5D6B7D5AB4E8045" modified="2017-01-18" version="1">MPPLTPLQISQLEEYGQNHFGENKELAFVPMLLGFALTCSFFGLLVLQVLFWVWRTAKRDWWVIKVVVAHVFMSATAYMVLEFYWISQNFATGFGTYYRLYKFSPIADFFLITTIMQTPVSGFFSLRAFRLTGGNLYSAIVPNVLLFISFGSCIALRIVAPEYATQIVYSNHPVTFSVLFVWAVTAMIADLIVTFTIAYALLQSKLGFTGFVRTDKLIKKVIMYILPSSPHVMIGGLMEKCSISVEAQMIPTLSSLAFLITFATTPSTEISAIWLFTPLMYPIAFMAVLNSRKGLARQLAPRLGQVADSSQPPTLRTSSSNLTYDHPGLEGVLPQLDRSPKESGRVQAGQVAAFPACLKVPREGEGYVKEEKEGKEWKSEEGRRDEKAERDEEERIGMGQRLSRQRYDIISATGSRTGTVSGEDSVGSVNVVLGGDIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE42</accession>
    <name>A0A1E3IE42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_07219</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex, at least composed of TIM23, TIM17 and TIM50. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028845.1">
        <property type="nucleotide sequence ID" value="XM_019179228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE42"/>
    <dbReference type="GeneID" id="30196430"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="235"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN86853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="57643" checksum="118BC36473010709" modified="2017-01-18" version="1">MLRTATSRLLPRSLPLRTFSSTPASFIRIRSSAPSPAEKPPHVPEDIKNPEVVETQVNDLGGQEVRGAPDLGTGKAAAAAKGKEAEAPLEPPSTSTTLNSQPSATPGAAAEDIPDTPDFSKLPSLDIDPDLPAPAAIEQPKSEQNEGGEKKKTGAGKKEYVSSHEKSRRMWIRLGYGGLAVGAIGAILTMESKPVEGAGKSEGIVTQVTNNVSELMDYFNKPAFKQLLPDPLPPPHQRPYTLCIDLEGLLVHSSWDRQHGWRTAKRPGADYFLAYLSQFYEIVLFTSQPFYASPLPPPSETTGGPIAEKIDPYQAYIPYRLFRESTRYLNGKVVKDISYLNRDPSKVVILDTNAEHVGAQPENGIVVNPWDGRAGDKGLVDLIPFLESIGIFAPKDVRPILTAYAGKDIPTEYAKKEAEAKTKAVEEWERAHPSAATGAGSGFLSSMFGSVSAPGQTRPNQPMTYLEQKRAQAQRIYQEEQKYWAENADEFKKLIEEDKQKQLAEMKGSLLGFLGGPGTKTPEGPKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEH0</accession>
    <name>A0A1E3IEH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028703.1">
        <property type="nucleotide sequence ID" value="XM_019179347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEH0"/>
    <dbReference type="GeneID" id="30196556"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN86326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="753" mass="81083" checksum="0510574D6856CACE" modified="2017-01-18" version="1">MVNEADTPPTNRLHHDVDREEMEDGGQRRVKRRTGPFKRSRTGCGTCKRRGKKCDEEWTSDGHCQRCLIGQFECTGRTLVESKKKKRPDNAPSPTRYASPSPTQAWQEEEREPGTSLSGGSIAALPPNALLSAAMQSNASSNSISPHNSFTLPTTPSHSLDNTAFTSHASSSGAPRKTDQVQASAAANVNFAWYNVNHAPSPAPHHDPSSFLSLAQPAGGPSSQPAGSAMDWAAIFGGAGGSGDGSFLATTECGALAFDPALAWGKGGEATANDLLDPAFFGSFMGPGAVRFSRNDVSLAEIYARVIESWLVGIPSDTREYVRARLLALNDSSNTLRNVKYAVAASYIALLSSSSAQYYPRCRLSDLCRKAAGIVEPPYEVLGDNTPDPMGNVGISTSRRGEGRRGEGKEAPYEAGQISQRMKDYAEGVTAVVDADVDAGKWVEDASRTLRDVVVVDEAHLSDLLWGVIDLQFMEFVRSGAKKSYAHLALGDRLVRSALGSHHPGITLKSLNTPEQLSLRLFAVADLGRCIVERGRRTIFNFWSDHPSEASSAEPPESSAWSSYLGLPDPLLILLAEIVNLAADLSSSSSASIKEQAGELETAIRTWKAPGIKLQGAGAEESGVGVGRVVVGEIWRLTCLVLLYQSVHRVGGLHPTLRHAQSEILSLLDALVPLPRGDLASSTALPAFLAATLSITKQDRERAMRHLLRAGPEKVWLDNVAVVEKIWEEVDESGQLPDWCQKMNKEGMCVAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL9</accession>
    <name>A0A1E3IFL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028929.1">
        <property type="nucleotide sequence ID" value="XM_019179011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL9"/>
    <dbReference type="GeneID" id="30196204"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16153" checksum="7270EE9E5082607A" modified="2017-01-18" version="1">MPLKEVHREYPLIDADPHFKRVVSYMRPSDYGVWAGATAAGPGLLYLYERVAPTLSNPASLKGALRVSGVLGFMAGFMLSYQNSSLRFWGWRENAAEVARDQAELSQLAKEGKPLYGESQLNPYLQGVAARNSMWSQLKLAAFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFX0</accession>
    <name>A0A1E3IFX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028808.1">
        <property type="nucleotide sequence ID" value="XM_019179191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFX0"/>
    <dbReference type="GeneID" id="30196389"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="33786" checksum="2EEFBBB0161E08A9" modified="2017-01-18" version="1">MSLQGELTTFPCNNFIYPIFTSGDLASERAVLFIGGLTNGIGGVAFTYPLSEALKGAGWRLQVLSLSVFVQFHWSSAFGGYGTGSLDRDREEMQTIVKHLKSKELMRSIGVKTVVIMGHSTGSQNVMHYLSSPSNADPSADIHVVGGIMQASVSDREFCKDYKHYNDTLPLAQQWIKEGRGDDILPKAFCDKAGFGDVPMLMSAYRLHSLIGIGGDDDYFSADIPSDPTPPFTHSLSSSFGALTTPALALYAEGDAKYQVAHPTELLPKWAEAAKGKLQWRILGGASHGVEEQGPQGVLCEEVLKFVKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJQ0</accession>
    <name>A0A1E3IJQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS transporter, SP family, solute carrier family 2 (Myo-inositol transporter), member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029387.1">
        <property type="nucleotide sequence ID" value="XM_019178686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJQ0"/>
    <dbReference type="GeneID" id="30195843"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="58"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="558" mass="60239" checksum="C71E35D5AD425DC2" modified="2017-01-18" version="1">MTVAHLENAFTDKNMNEIQVVEDTGASKPPSGFGGHLIDENLVKIEGEDRVTPYLCFLISASAFAGFLYGYDTGVVGVALPLVGNDLTGSALTSAQQEIITAGTTIGAIFGSAILGGWGDRLGRKMGILISDVFFTIGAVVIASSYSVGQMIAGRLILGIGVGGAAAIAPLFITETAPTSVRGRCIGVNAFFIPFGQVVADAVGAGVQTMPNGWRLLFALGAAPSLIQLILFHYLPESPRILILRNQLPAARTVFRRIYPNASEEMIDYKFRVAQELLWRKGSYRRSITCVTMAQMAGQLTGFNTLLYYAGTLFSLLGLSNPALGALIPSGTNAFFVLCGMTVVDKVGRRGLFMIGVPILLSGLIWNIVAFHYLCIPTNGFLDTSYTYPTKNVGIVIGGIVFFTSGFGLTYSHLAWYQAEFLALEVRSVGSGIATTANWVANLVVSVSYLSELETLTPAGTYGLYLGFSALFFIFLVFCYPETKQLSIDETSLLFEDDYGVKRSRQMRRERQEARRRIADDEMAEVAEATLEARQDKGRAVSAGELGRFMSGLKNGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK55</accession>
    <name>A0A1E3IK55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029373.1">
        <property type="nucleotide sequence ID" value="XM_019178672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK55"/>
    <dbReference type="GeneID" id="30195829"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="278" mass="31030" checksum="6D7A39BFEDD93C4B" modified="2017-01-18" version="1">MMSIDDYDYVLSSASRSSATCVQNATVKLRRVFQSLVTYSVFSSSIPRRESLWTRSCWLRRRRSGEGLVWSEGDNVDERGTRLLHTTSTTEQVALLSLHMRKTTPSLTFDISIADAIPWSSRRTLSMLPPKRKGSLPTDFLPFLALGLVSRRSLLRPSSGLFFFSLMDALLDCIDKGEDRTASLSCLANQPRLIPSSQLSLPGLSPLALAEKDMASQDVDRVLCRVLLIRVRSYDGLARGTRVTPDIGKVVTFGEQGLGKWEGSARGERRGERDDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMG4</accession>
    <name>A0A1E3IMG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029524.1">
        <property type="nucleotide sequence ID" value="XM_019178368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMG4"/>
    <dbReference type="GeneID" id="30195514"/>
    <dbReference type="OrthoDB" id="2124108at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="35505" checksum="2953F8B8CAA785EA" modified="2017-01-18" version="1">MPTADSSNYAAVAKHDDEAASHTQPEAYEADLRVSVKALRIAAAVERSKTEYKPEHAYTERKWLKPEAYSEHPPASKSQVDRQRLGESSDFSPAQEYAASSLYFSDPPDYSGALELVLLKFDSSPKAKPLGGLSRELLDIGLNASIKCGDKEKALLLANSSKTIWKGQFAGVAAIAADAYMSALHYHEAVKPLLMTLAAFGIHYPIISRLSQALQRILEDRAVIRPATNHLHVMVNRAMFHRKASFERPIFREEADPASKSDIASDQPAIDEGIARDPLDTEAVALELEMDAETKAALKACWKRMARGLEVEMEPDKSVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INI3</accession>
    <name>A0A1E3INI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin structure-remodeling complex subunit RSC1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029685.1">
        <property type="nucleotide sequence ID" value="XM_019178247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INI3"/>
    <dbReference type="GeneID" id="30195393"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="451"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN90163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="816" mass="90094" checksum="6D2107004F38820D" modified="2017-01-18" version="1">MPRPTPMPDHQWRACTAILDAVYGAKAGSRKISRIFQSLPDKDDFPDYYAAIPEPECLDNIAAQLESQAYATPELFFKQLHLVFLNAKHYNEEGSQIYADATRLENQIHQDWVFAASSHTFSHTDPYHSSPVKPGRRPKRTSVTPAPSIPPVLLQTLSPIPEPSLAGSSRSPASASLPKPPQSAQPSPRSALPSMSQPQTLQQAYMATPNVPMDPAKAAQYAADQAVVAARDATLPRWSGPKEVLSGNPAPGGVPGSGWWGEDAPDYERTTGGPDQWPFRIRAVVGAIEGYKDASGQRLAEILDVLPEAPSNPYLSYEYPLSFAKIAATADAARYLTLKDFDMDMARLFEKARRWYHDGSPEYGQTLVLQRLYNALTAPYPIPLPPSGVPAPSVTQFASIPAGPGNARSLHEATQEMRAGASEDQVGYAITTFRVGTKDRIFTDEARHKGVPYRVGDYVHLINPDDPTRPIVGQIFKTFVPTKGQQTHHVSVCWYYRPEQTVHQPDTMFYEREVFKTGQFCDHPVEDILERISVQFYVKYIRGHVCNSRFNHRDYNIVRIKNWNSCIPEELRQTDFMSIVPFDRPIELRMLPSPFNLGVRGPGFFGDPKKILGGDTANDDDDDEEERPKRGRGRPPATPAATSYGGGIGVPGSARGTPVPQTYRAPVVSQQGHVPAPAPPVQAPPPPKPVVQPVKTFAGLLGGQQILDQVAHKETLPQEVAKLFPQDVRGNVLWFSGAPIVPGAISIPQQQAHSLAYLEYLTRRRRGEDWVPPKKSRKVEENGVFPNGQDAGGDEWWAEGKSGEEVRAELEKIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ27</accession>
    <name>A0A1E3IQ27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029806.1">
        <property type="nucleotide sequence ID" value="XM_019178087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ27"/>
    <dbReference type="GeneID" id="30195232"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1051" mass="114755" checksum="7AB59A0CDB674895" modified="2017-01-18" version="1">MAFQSPLIAIPRKTTQDVDWTGPIRHVIAASYGEDPNAYQEECSVLQRVRQDAVRGAGSDFTGRDLLYKYFGQLELLELRFAEIKVSFAWNDAFTTKLTTQTSLAFEKASIIHLISAILSSIAQSSSRSDPEGLKRAYYNTRACAGMLTYINENFLHAPSTDLGREVVHLLIGIMMAQATEIFTEKLIEEKKSPALVSRSANQTASSYSAAVEEMKEFQGKGVFDRNWLNVLQIKSKLFASIAQYYKGTADNAAGKHGAALVRFRLADTFAQDAQRQSSSFNYTFVATATPSLPNDAGSNLHEIVKAHTTVCKEAKEQATKDNDLIYNEVLPSEASLPAIEKLPPSPPITIQEVYANPEVTRLIGPDIFIKLVPLAVHESASVYSEEKAKLVRAEVERVESSEGEIRAALDHLGLPGEILKWRKIVEDDSPQGEVELSRELRQLVDTSGDARNVERELSRLSNERERCERELRELSSALDNESRECERMRAKHTPQFTQSPSGPQTSNLRSNISANLSALSSAAASDSQLSSLYQSVQPAIALLSSGQSQLESIASQVAKGKPQNAEDRGMSLLDLQDEDEGQGGLSAKEKESLQKAIKEGTEKLERLGKIRRERDEVLKDLKEKIQADDVSNLLLLNRRSSNVEPQLFASELEKFRPYQTRVAAASSAAKSLTQELEMLIAQVQRGRGVKDLSRKDKEKSKRVGQWEKGLIKAGESLAEIRAGLGKGLSYYESLARVIEDLKREVRGFVSSRDQERSRMVSEIEARQRLGGAASPSTSGTRGLEERLSSLSMGAPPPPSRPGVSSATPTLPAPPSRSAPTPHYPPPPPPPKSNPYDFSSLGGSSAFSSAAAPSPPAHQQRQGSYGLYGYASPTSPSQGAQPQQATQPLQSPYPAPPSQPARPATQTYGSYTAPQAVYTAPPSQPGYTSPPPQQSYAPQGYGQSGYQPQPPSQPQAQGQGQYYPPPPTRPAYTSPPPQQPSYGGYAPPTSGYASQAPSGYTQQPQGYAAPPQTQPQPQSQTQGQQYGYQAYGYSDSQLQQQQQHGGYPQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQH0</accession>
    <name>A0A1E3IQH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029934.1">
        <property type="nucleotide sequence ID" value="XM_019178215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQH0"/>
    <dbReference type="GeneID" id="30195361"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="239"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="514"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN90832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="79842" checksum="E6AE8EA723EFED40" modified="2017-01-18" version="1">MTVDPETATQVKLLTLLNVSAVKRPRDRDLPGGHRSPSVRDQSVAQGSDAGEQPEKKRKSVIWGGEIGPSGSQFNKGGKGKGKGKAKGEANGKSAVIGKGAVIEEVQSGSEEELAVDEEESDNESQASTSADLFNLHFGAEPSALTPESVKAAEANQWKSERKTLKGFGRAVEITPEGAVASGDVKTRITPSLLPAIKEASSSNPLLSTSLSHLGSYKDFYLHSLDGEADGSEIQLMSEHKEAMRKAVAIHALNHVLKTRRKIIRNNEKLAHAAAAENPTSVPEPPRDQSFTRPKVLFLLPTRALALHYLKNHLSPLAPAGTQLENQRPFTTSFSLPEDEQDPLASSSAASEFPIDHLANFRGNTDDNFRFGLKLTRKAWRVVMMPANEAKLMECDILFTSPLGFKMTSEREDSTDLLSSLEITVVDGADVMQMQNWEHVQFIFNNINKIPASPHGCDFSRVKPWYLESQAQYLRQTIILSRYDTPESRGLFNRHCRNLQGKIRLEKTDFGGVMDRVRPGVKQVFERIDLEGPKGMEGEAAVDEVEKRLTFFTENTLPALLRAAISRQNTLIVVPSYFDFVRLTNHLRKEDKVSFAAISEYSSGSEISRARTLFFKGKKAFLIVTERFHFYRRYKLRGAKTIVFYSLPDHAQFYSEFMDTPFQVSKNKSGEEVDVDEAEVSSRVLFSRFDVLKLERVIGTENARKLLKSGDGRFEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQN4</accession>
    <name>A0A1E3IQN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029768.1">
        <property type="nucleotide sequence ID" value="XM_019178330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQN4"/>
    <dbReference type="GeneID" id="30195476"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="133" mass="14942" checksum="F3C62F3CF8033D8B" modified="2017-01-18" version="1">MFRATRVPCSALRPLKTSTNIFGLPVHQNPLPALTTIYTTTLASLTHLPSTSVYRQATEAITKHRMSIVEQAQGNVEEAEEKLGGRVVEWVIEEAEREAALAAKAVEWKVWEPLVEEPAPQQWRYFEPLSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQQ4</accession>
    <name>A0A1E3IQQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil transporter FurD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029788.1">
        <property type="nucleotide sequence ID" value="XM_019178350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQQ4"/>
    <dbReference type="GeneID" id="30195496"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="574" mass="63533" checksum="69600565905DD7B7" modified="2017-01-18" version="1">MISAETLKRRATSRSAWVLPKEESCVAPDEVWSNKDMDPAPVEHRIWTSWTFFAYWISDLITPGGWATSSSFIELGLTWWESCLAMYVGGFLVAIVITSNGYIGAMVHTPFAVTSRSVFGYWGSKFVVFSRMCTACFWLSINSWSGGVFISLMIEAIWPSYANLKNSIPANQGATSRDFLSFFLFWLLQFPFIFIHPSKLKWVFNVKAALVPIVACGTLIWACIIASPNTGRALGSPANRAEGGTARFMAFMYAVTAAQSTWATLSVNIGDFSRYCKKPSASYIQMIVFPLLYAGLSFFASITASCVAYTYGTENSYYQPYDIVALWNTSAGGRCAMFLASFVWYLGRAMCNVTTNITANSISAANDMTSLAPKYINIQRGQFIAVTIGVWGFVPWKVLATASNFLTFMSSYSVVLAPIAVIMVVDFFFVKKQKLNVYELYKPKGIYRYSKGWNWRAYVALAVAVAPNLPGMANAINDSIYIGNIQYIYMVSNIFGNTVALTIYLLLNRFFPPQSAIIETAVHDVLAEPEYTTYDSTDPVAKEEAEVGGEAWSAAFSKNGEKGLEGETDVKSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITW3</accession>
    <name>A0A1E3ITW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029972.1">
        <property type="nucleotide sequence ID" value="XM_019177933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITW3"/>
    <dbReference type="GeneID" id="30195069"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN91346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="429" mass="47933" checksum="54B80CC719A289EC" modified="2017-01-18" version="1">MRITKAQFNGLDQYKYSGVDKSVVSKYLLNPFWNWLVTLFPKTIAPNTITFLGLCFIFTNIGTMIWFDPTYAGVVLPNWVYASFGIGLFAYQSMDAIDGKQARRTGMASALGEMFDHGCDAINTTLEVVLAAHALGLNRSWWTVASQVFSLCNFYVSTWEEYHTGTLFLSAFSGPVEGILLICGIYFITAFHPLGSLFWAQPLLKPLFLVIPQTYPLVQKVDVLLEHLGIAKHVTLETVPANVAFMAFGALGTLGNIATSYINVISARRKAGKPILPPLAGLLPFFTHTGLLVAWLHSEIRGGVCIVHDHRILPFIGYWGMAFSYQVSQLILAHVTKSPFPYWNGMMIFSLFGAIDANMGSLFGREPLVQSSPVAANVFIWMSFFVALFNYIRFAREVIWQICEYTGLACFTVRHKDKDGKWVDHVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU13</accession>
    <name>A0A1E3IU13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030234.1">
        <property type="nucleotide sequence ID" value="XM_019177850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU13"/>
    <dbReference type="GeneID" id="30194984"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN92100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="37961" checksum="DF32F88B34943AE6" modified="2017-01-18" version="1">MSTLQGFTIPKTQTAAVVESLGAELKMDNNHAVKTAEELKPGQCLIKISHTGVCHTDLHAKTGDWPVPSSHPLIGGHEGVGIVVALAEPAETSPVKLGDRVGIKWLADSCLDCELCRRGYEMNCPNAQLSGYTVDGTFSEYVVSYTRHVTPIPEGLDSAGAASILCAGVTTYKALKVSNTKVGDWVALPGAGGGLGHLAVQYAKAMGLKVIAIDTGDAKEKLVKSLGADAWVDFRTTKDLVGDVKAITGGLGPSAALVTAANKSGYTQAIDYLKPSGTLVAVGMPDAEMGANVFWTVFKSIRIQGSYVGNRQDAYEALEIAAAGKVKVVYEQKTLADLKDVYEDLEAGKIAGRIVLEVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU34</accession>
    <name>A0A1E3IU34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030257.1">
        <property type="nucleotide sequence ID" value="XM_019177873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU34"/>
    <dbReference type="GeneID" id="30195007"/>
    <dbReference type="OrthoDB" id="2573296at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="209" mass="21687" checksum="D73FF7E744931582" modified="2017-01-18" version="1">MPPPPIPTSSRPTSYNPFRSSNTIPPVAPATPPPSYATHTAHPTQPPQHPSYDAYEPVQYSSLSDLQKNKPPKNTSTQTSGWGGRGSSHGRGDSSAGASSSGGRRVPPIPQEGMMPAVPSAPPRRDVSTTAATAPPPVPPRNSSGFQSYVPESAKSGYNTASERVVDGWNSAATVQRKDQVLSGVGKLGAGAFKLAGKGVYQVGKFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT8</accession>
    <name>A0A1E3IVT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030299.1">
        <property type="nucleotide sequence ID" value="XM_019177548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT8"/>
    <dbReference type="GeneID" id="30194678"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="35443" checksum="F7BB76F838388925" modified="2017-01-18" version="1">MAPTNPFHDSQTTATANNAHPSDGLPEDQIPSEPPPAYTPSATTGTGESTVQAGPLRPDCSGPPPMPDWVERQQQQQQQQYTGGSGVGVNLTGVGMGYGHGGQGHSQGQYANGNSSSDETKFPPPPRHPSATSSSARPPPPLPSRDSTTQPSSSQSAAPTEAPTPGRPLLHRGQMLVYPGGFWCSKCNNTGYKANDPSNPHERDWKKYGRVYNSALAHSYTQALSAGLHMSDNFQKPLPSYAPAGHAPASAPYSGPTSGQYSHLPPAPGSSGKWSTYPGQGQDPGQSYGHLPPPPQPQRQQQLQYPAPGQQIFVQRTAGMAPPGALVVAPGDPRIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXX6</accession>
    <name>A0A1E3IXX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030575.1">
        <property type="nucleotide sequence ID" value="XM_019177422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXX6"/>
    <dbReference type="GeneID" id="30194548"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="24076" checksum="1D0EA7743B2F4B1F" modified="2017-01-18" version="1">MAQPVEQWIYDIPPVTRLWVGASLATSLLVECQAVAPLQLYFSWRGAVVNMQLWRFITTFLYFGPISLDLLFHVFFIMRYSRLLEENSFANRRADYAWLLFLCASFLLVVSSVTTLPFLSSSLAFALVYIWSRRNPAVKMSLFGVVTITAPYLPISLIIFTWMFQGGYRAAIPDIVGMLAGHTYVFLQDYWPREMWSISGNPEVQTPAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXZ5</accession>
    <name>A0A1E3IXZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030403.1">
        <property type="nucleotide sequence ID" value="XM_019177652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXZ5"/>
    <dbReference type="GeneID" id="30194784"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130001" evidence="2">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="14199" checksum="BC32B7C64124AB26" modified="2017-01-18" version="1">MRFATAFAVLAAVAATAGAAPTGQQESASLSFFGPPPSGPPPSGVPPSGVPQQKMGASGEAPSGPAPSGNPPPPASGSGSAVALPLSGAAQQRRGDVSSAAPPPPPPPPPSGSGSAAGPPPSGAPQQKRQDASGAPPTGEPQSGDAMATAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY07</accession>
    <name>A0A1E3IY07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA-associated factor 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030557.1">
        <property type="nucleotide sequence ID" value="XM_019177404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY07"/>
    <dbReference type="GeneID" id="30194530"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000122">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="32986" checksum="4C2E2709EBE41B83" modified="2017-01-18" version="1">MNQIWHSLVDTVRVLPTIPTDHVDQEKQTVNAALEKLNVLMALRRGERSTPDPNPHPRLPTAILPSAAVQGATPGSGGGAKRKRKGSFSASPAPMTLDLTGTAMVIHPSPLPTASAAGTKPSTPMSREATGKHRRELYADQLPLQPGRKVAFKLPAKSTRDGEDSQGGAGDDWILATVKRCILQDRMRYEVQDVDDGNTYNTTLRSIIPLPDPASPTQLTSNPANIEDYPRESIVLALYPDTTSFYRATVVAAPYPGSGNGLGIRGQGHGLKPDPGAKRGVYRLMFVDDDGHVQEVQKDYVVPYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY45</accession>
    <name>A0A1E3IY45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030573.1">
        <property type="nucleotide sequence ID" value="XM_019177420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY45"/>
    <dbReference type="GeneID" id="30194546"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="355"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN93468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="476" mass="51971" checksum="5ACBDEB31CCB69E2" modified="2017-01-18" version="1">MSTPRATRSRTATPLSVRTRSTPQASAPPSHHHKTADELALEEAASLLHTPTTARLRSTGSDEVLDGGSARALRHRRLNEVRHEGDAVRERSKSPQRDERRHSEAPSTAETEVRENDGEEKDKQATTQQGSDTGDEDDEEASMELPGMSGISEATASVAGDEEEQEDDEPVSAALSTGRIFSQPRQEVEFGEAMSASGSETASAGSSSSEAASDSDSESDSSEDSESESESDDDDQMERLLQAARDAAATKAASGNKQGEDRAEADGEVVLQFDKDQFEKKEAPIPDLSIANLPKTHLSFTKEGQAKATIPVPSVASSSAGPSKRGPTSNKSQELDDRPYEPQLSKKEKALQPRKATTSELWSRIPAPRADILPQMKRDYQALSLANSLDPKRFMKGGSKNDKAPESFAIGTMLETSRRVRDTTLTKEHKYRPGQVVQNIIRDNDMEGYAKRKYGDLQSSRMENGRGKGWQKRTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY81</accession>
    <name>A0A1E3IY81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030664.1">
        <property type="nucleotide sequence ID" value="XM_019177511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY81"/>
    <dbReference type="GeneID" id="30194638"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN93559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="675" mass="69327" checksum="1399F36BD881E85C" modified="2017-01-18" version="1">MLPHPHDLFPSLDNRDDCVTCNSTSPTCNCASGEKCVLTSRTCNQCPSIQCIKSASSSSGSSVNAGVIAGPVVAVLVIASLGLFWWLRRKKRRDMKRVEGLADRARKAESAGFQLSPSRSPPPSTRPSSSFPLPPPSASRRSPLPPAPVNAEYYDQNGSTIRVYSNNGTINADPNGDPFSDRQSISTMGSGGTANIIPIQYIPPSESKDGLSKVASTDNGETAQSAAARLDQARQNLSKLGAPSRPARSPDLDLRLNPPNAPSAFDPGALRSPGAGSANWRDSYLSGNSAAPSYFSGQSDFQLDQPKIVTSRQVQVGRLQQAEVVNFGAREGVLSPVRDEEDPFDRTPPAPGLSPSDASFRSTGERILTPTNRKFGASASPTTANGQEERLDAMSGGSSGDLRFSMGSLDYRNSVSTMGTSRYLASAITVPVLGHATPATATTPNSAFPDSATTPLPTSSSASASASASASASASASPLPSALPLSRYNSSGTGMATADTDTRGSVLSSKSFADSFLGAFPMIPPDQQRPPVPSIVSRGATSPLSPSSSQGQGQGQGQGQGQGQGQGNVEMISRPPIAHRPPPPGPRPPSSARGSGMERPSLDDERAGGGGGGGGGRKKRPETQDSFLGTFPFVPPNMDDLAGMPEAAAGPGPGPGRGSGVGSPVGGSGAGEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1K2</accession>
    <name>A0A1E3J1K2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031039.1">
        <property type="nucleotide sequence ID" value="XM_019177007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1K2"/>
    <dbReference type="GeneID" id="30194117"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130086" evidence="3">
        <location>
            <begin position="21"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="497" mass="52937" checksum="800109D43E4D11E6" modified="2017-01-18" version="1">MCTFLVSALLHALLLSAATAHPHGLHQAAQHERRQDDASPSSATSGSVPTGVALGVSLGLDDSSSTVSTSATSTTSSSDAVTTSYTPVSSLSFASVTAAPAITASSYTSLTNKIPDVLSRSNEIAVHSWELGTLINTLLEVYNPGLMPFGWDSGAVDDEEVPWNALEIARDTISHYDWTGAPNATTGQDLSLYLDNSTTPQSHHSQALIGGDGALGDPVSLVPAVWLLAEYAQKDEVKSKLQLRDADDYAWAVGNQLNYLFNGPTSSNGTISQREASFELWADMGYMVSPSLAYLGLTTNSSDFLTKSLEQFTLESSALLETIHDVYLHILNGDASLWATGNGWMAYGLMRDLASVSSAGLDSAVGNYATNTKNTISGVFQGLFSQLDDDSLIPDYMHQSNATLAVGDTSGTALTVAAYYRFLKLAPELTNDNLTTLAEQAFDGVVAKIDDNGWVTHAVDPMGTYGWVVYPDDLTLHSPEAQAFAALMWKARTDYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Q9</accession>
    <name>A0A1E3J1Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031043.1">
        <property type="nucleotide sequence ID" value="XM_019177011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Q9"/>
    <dbReference type="GeneID" id="30194121"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="17935" checksum="D00D3DE287F72DCB" modified="2017-01-18" version="1">MSNLAQARLNEERKQWRKDHPFGFYAKPIKNPDGTLNIMKWEVGIPGKVGTDWEGGIYVVKMAFPDDFPTKPPKCQFDPPLYHPNVYPSGTICLSILDEEKSWKPSITVKQIVLGVQDLLENANVNDPAQDAAYQAFKYDRPTYDKKVKAQAIARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2N3</accession>
    <name>A0A1E3J2N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030907.1">
        <property type="nucleotide sequence ID" value="XM_019177326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2N3"/>
    <dbReference type="GeneID" id="30194448"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="877" mass="94314" checksum="E2209CF0D929E856" modified="2017-01-18" version="1">MSASEQNIIHSPPDETIVRYRTPHTPSVPSAPAPIVNTGTTANPNALGLHIYATPSPSSSPPPSSPQPQFENTSDRGKTKARSSAHSIKTDNPKAGSREDWALAVAKRERKPAEGPTHSDLSCERCRQQGQTKCDRNDSNICTGCLVAGVECLYHAPVGKRGSNMTPTRALLVQGRPSMRRFFTGTPSTRSLAPSSTTSSLTSIIAPAATKAKGIPSVEPMVQPTTASASRPENRSPARITIVNKAKASDGKDPASKKHARDHTAGYTQNSISCERCIQRRMRCVRDDFNSCVNCLKAQAECQYEITSEGKQWSKQASRELFAMERLSIGAPPSPSFAPSSTNMSSLTSITSTATPTTQKPSVEPTRTIDFTGNPTASTPKSNDHQSSAPLIETNSTKASGGENTASPEKKGRKKHAPGQTRHFLSCERCRQRRKQCEHDGFNKCNRCLLAGAECLYHVPTGKRGSQKAFTRERHAMGRLSMGDIIVGIPPTPAVASSSRMSSLTPTVPTTPTKNPSGVRLTIESTVKPTTVKPTTVRPAVEPAVISTVQSTVEPAVQPIVEPDVTPTIEPSDEPYVEPSVGPDPDVKPTIKVEVESPVEPSPDPAVAPAAAPFPGDVSAEFPPSFTTPNIFAVFTLPSWFETHTMSPPAFGAAGHVRDEWEYNKLKIMDGDMSHIFSYPPVKPPLKSAFEPPVHFLAGLEPSFCLNDISAPSTPASLDASQAPLPAFEAQGLYGSERVYYCKILGFDMDEIFSTPLAAPEDKAPVTSVTPLVTPVKPTLRYSASEPALSTLPSLFFNHNSLVPRTPPSLSLPRTMPLPEVEGDVVAEGEHVDRDTQSMEMEMSDVDSTFPPTSSFNIFDYFTPVVDEAAEGVMKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2S9</accession>
    <name>A0A1E3J2S9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030792.1">
        <property type="nucleotide sequence ID" value="XM_019177211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2S9"/>
    <dbReference type="GeneID" id="30194330"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21206" checksum="9909C93A22471CB5" modified="2017-01-18" version="1">MDNNTSPGPSQPSQGATSEDTVRVPSSGLEFFEYRRRLFLAGLPAPSTPTGEPLPDFYEVPRGLPDPLPIPIRKQPSNASMARVEAALSQEGVEYSKEMWESGVRQLAEKLHEGRKFTKGMRLSLVIKILIASWINDGLWPTNTRTGLPERPPESPLIEGIELFPDGVPVKVIDTPEDQLPPKNEYRAFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2T5</accession>
    <name>A0A1E3J2T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030802.1">
        <property type="nucleotide sequence ID" value="XM_019177221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2T5"/>
    <dbReference type="GeneID" id="30194340"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="34"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="324" mass="35273" checksum="6A8A0DA2710DA1C7" modified="2017-01-18" version="1">MPVPVPPRIPHKPSRPFVSASYRPPEEAHDGLFRLVLITSGSVASIKVPDIVAALAKNRDIDVQIVATKASTYFYSQNDIDSSVRKSLQLSDSTTSDVGYKVWTDTDEWSDWRKVGDPILHIELRRWADLVVVAPCSADLLAKVAGGLCDNLATSLMRALSPSTPVVLCPAMNTHMYQHRLTAKHLTIVQDELGYLVSGPQGGGRLACGDDGPGKMTDWRDIVSVIEGFAHMFHNKQAPYQPTSVEGVSPALSSNPSNPLPRQNPPTPNRSPSALRSTNPLPDTEREKDTGCKPGESAGVKDWRALCGPEGGDGRAWQKKYWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J323</accession>
    <name>A0A1E3J323_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031240.1">
        <property type="nucleotide sequence ID" value="XM_019176765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J323"/>
    <dbReference type="GeneID" id="30193862"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="6">
        <location>
            <begin position="144"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="725" mass="79036" checksum="09AB5EEDADB99FBB" modified="2017-01-18" version="1">MPKATAKKKEKKADFVKAKLKLGKGKKSASNATDTSFKARSIALPGQEALNRALLVSEGNGPSEPTTANGLTLEDLLNRLRHPNSGVRKESLGGIKEILQQGIGKEIGKVLRALGGLVADDDAGVRKGLLGLLEWYLAHLPMSALSPHLPLLVLQTSSALSHIFPEIRLDACKLVHLLLQHVPAHVLSQWPYESSNILEGLRLAVGLGGEKGVNSSIGRLTGGAKLVTMKAMREFVRVGLDSGEERKWGAGWVREGGKREGKRKEVREEPMLEDLALEGWLVGAQGLKDICDGGNVWEVGRLGSHGGQGNEAGVVSVLSQLYIQLHPLLLSTFLENAPTAFSPSAPTVPTASEDIPLQLCVATASLTELLANAILTRAPAESNTPELKEVKACIFDFQRRMTAWFPFASRTAPTPSGVTPEFELSLAYADLALLLAPRPVELVYPTQVDRRAKELGWRERVKATEEAWKKMQTAEKGAKGKGKAGQSQWAMEEVAEWVVDVLAPSQDALAPSLTPETYKALLPIVWDLLVQPPASTSEQADIPSLVGTSLLNHLLRQSSTSLIRELGDQFLISLIEVHEQKYMTLPFYLPPSSSIRPLIQGWFDSIPRTLFELGPKAPSTTQHLLRFLLSAALQAPAAYPQPYSLLDFSGFSQFTQKLAAFFWVKHPKRGDIPGAWVKLEDKEVKRLGLDVAKAWAGWDQGGKLAEAVRKACEGSEGELGQYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4C6</accession>
    <name>A0A1E3J4C6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031358.1">
        <property type="nucleotide sequence ID" value="XM_019176430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4C6"/>
    <dbReference type="GeneID" id="30193524"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="253" mass="27240" checksum="0E58B5BC01A88DE3" modified="2017-01-18" version="1">MTFPDPAHAPSSLGNSHKSHATSSSADFGAFTSAAPPTPHSVHHLGEADLLGSYEDDQHVAEPQRGQPPPSPGAQPTWPSAFDPLATGSTEIPPYPPHLPTNTIDRHSSSPSATYISLPPRPTEISPNYVPHARTRRLSSFTVATSPTSPPVFTDTGDELVFHPAHQSSGNTALGSIQNVQRKSSTSPTSSRVKPPTPHSSILWQQQQSLPQGGSLCLLRKFSLQPPICLGITPEVAMRCLHIKHLHHHFQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J555</accession>
    <name>A0A1E3J555_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031440.1">
        <property type="nucleotide sequence ID" value="XM_019176512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J555"/>
    <dbReference type="GeneID" id="30193606"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="31953" checksum="66C2D58F8FA1A9F4" modified="2017-01-18" version="1">MSRSYDRGNPAALTVFSPDGHLFQVEYALEAVRRGTCAVGVRGKSCVVLGVEKKSTLQLQDPRTVRKVAMLDDHVCVAFAGLTADGRILIDKARVECQSHRLTVEDPVSIEYITKHVAGIQQRYTQSGGVRPFGISALIVGFDPNDTIPRLYSTEPSGIYSAWKACSIGRASKTVREFLEKNYEENLERDDSIKLAVKSLLEVVQTGAKNIEITVMESYGVVKNLEQEDIEKIVAEIDAEKEAEAERKRQRLAATQAGQASMAMGSSAPSGTQTPSGAAGGSQEHHSAPGGDSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J670</accession>
    <name>A0A1E3J670_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031609.1">
        <property type="nucleotide sequence ID" value="XM_019176199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J670"/>
    <dbReference type="GeneID" id="30193290"/>
    <dbReference type="OrthoDB" id="2562427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="254" mass="28061" checksum="5DAAE8E377E24D42" modified="2017-01-18" version="1">MPGPANEAPTSAEALFYQYVFPRLPTDAQTLFREPPTIANPSSFLPLFRLLAPYIGYFITLVAFIIVWTALSSIVGYMSRIFRFSLRLIPVIAIAAWVMASSEQGTLEELLELMKQWAGLVPTDGRREASPGVASLVNLLGAAKDGNPSSQPRRNPSRQGRARSRSPPYSSREKPDPVAARADNKGAEKGQAGRLDFISSVLSSAVGSKNADDSANEWQRMLQDYVRQSVLKASGVDWLFGRQEKDEKKARGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8I2</accession>
    <name>A0A1E3J8I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein mago nashi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031642.1">
        <property type="nucleotide sequence ID" value="XM_019176232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8I2"/>
    <dbReference type="GeneID" id="30193323"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="17954" checksum="55EDD21D49DA74DA" modified="2017-01-18" version="1">MTDVLLNDKFYLRYYTGHSGAHGHEFLEFEYSHGRIRYANNSNYRNDSLIRKEMYISPALVEELKRIVRESEITKEDDESWPKKNVSGKQELEIRLDKEHISFETAKIGSLSDVEHSEDADGLRVFYYLVQDLKCFIFALTQMHFKIKPIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Y5</accession>
    <name>A0A1E3J8Y5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell cycle control protein cwf19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031792.1">
        <property type="nucleotide sequence ID" value="XM_019176382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Y5"/>
    <dbReference type="GeneID" id="30193474"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="570"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="701"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN96546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="829" mass="92822" checksum="58749C62E175971B" modified="2017-01-18" version="1">MGRETSPGRHSSRPREREHRSRHDDKEHRSRHGDREHRDKHRKHRDETEEDRRERKRHRKEEKRRDRNDDGLEVQDDDPSMWVEKSIDGTEAVSNIPTTDSLPLKSHISTSEAPLPPSTASGSAARERDSWMLEPTGSSASAPRDSREVPQSADLFESMGTEHLRKDPKADQPDPSKASRSYSSQRAQLLDGKSVDDYETKETKVQFGGPGSQWRMMKLRRLYEQSEEQGKPVEEIALERYGSLQDFNEALEERKYLDDKEERRKSRRGPGGLATPTGGSTGARTPDTGKRFMFANPASGDESFGSRPSSRAGFRKPGEDRDQTPNGRIDLLRRENSGGGTPGARPGASGITSSMAMSTPVPSVFTPTALTRSSTLPDTGSPARDPTASKPPLSTEQLNKLQAAVLRAKLMDDPNAEKMEHEYELERERSEAAANGGLWSGASDGVEVQVLPTLDGRGQLYDVGTGQAAEVELGPGNKKKKVDKFETRDKQGNLLRYNADDDSQSLGELVRQERFGAGSKDQKDIDAEMARAIATDGKFQDDLDYMDDNAEKLARRKLKSDALKRAFAINDYARTKKALDTCPFCYQDDRPPQTAIVALGTRTYLCCTETEELVPGHCLIVPLQHHLSMLEMEDDDWEEQNFMKCLMRMHADNNQGVIFFETITTFKQQKHSYIEALPVPARHFGNLPAYFRESILASEGEWTQHKKLIDFSTRPGGFRRMMVPNIPYFMVQWDYKGEKGYGHVIEGVKESGSGGGGGEDEEGEGDIGGAGKEDEFPKYFAQEIIGNILGLEPRKWRKPQRIAVGANKERARALGTKFQPYNWTVGNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J969</accession>
    <name>A0A1E3J969_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IQ domain-containing calmodulin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032006.1">
        <property type="nucleotide sequence ID" value="XM_019176093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J969"/>
    <dbReference type="GeneID" id="30193181"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN97404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="602" mass="68857" checksum="F8EA36D47E2E5440" modified="2017-01-18" version="1">MAIQTQAPLEPPIDTEGKGQIMDGPSYEERERAAVIIQKHYRGHLARRRYGELKLENEAKWNDLVKQSQDLKYAQEQLENKNDVNSRWRRAAQAASRLQTGDGLYSTPVHLTSNTTSVPGHAGDPSRLAMFEECVPENLDEKERRARRATFWGSFSVMGLGEERDDKKELPFQSKTLEQQHWLEMIDGKHRYGNNMKFYFRKWKEAETSDNFFRWLDKGEGKDLNLEELPRERLETERITYLTAEKRLNYLVKVDKDGLLRWARNGELVDTAAGQWQDAGDGGGIIPAKDGDEEAGDDVPVSGDPYAAPKKRLPKPKVSLATSHSHSKASTSSFSSDSWSAQSSDLDENEDTHYIGLDKANSGSWLSRHRKKITPGGVRTELLRKTVRRNTWIYVSDMKMNMFIGMKKSGTFQHSSFLAGGKVSSAGIIVVKHGLIKSLNPLSGHYRSSIDNFRSFIAQLEGLGIDLSHVKVAKSVLSLWGLSKYSKATKAQKDVFTHMARALHLSHNPTEEEKSQAVKDNAEKEDREHMERMQRLKEAETQEDEKRKQKEEAGVEEDEETEEQREESMRRIRREVLYGRQQQNVKIQQEKKKDTKQELRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBJ2</accession>
    <name>A0A1E3JBJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor 3A subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032078.1">
        <property type="nucleotide sequence ID" value="XM_019176165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBJ2"/>
    <dbReference type="GeneID" id="30193256"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="57952" checksum="4C8D07C7993AF6C1" modified="2017-01-18" version="1">MDSIVETQRQTHEEIERYEQALAEVLMQNPTATKNVTRRDRKAAEILDRIGTLRMELVDMYEDIPGLRPKELALLSAPGAGQDDLEEFYLRFNKIKDFHGRNPGINARQFLNEVDELVKGDGVQLIEVEGDEEPTIIDPLDSIFSGEEAYGKHLDLYLSHSQYLNLKGSTRLSYVAYLDMLKHGKVERTLDTKEKSNAAYLEYVQTLYNYLLSFFERALPLVDVRGKVKEAEASFEAAWEAGQVEGWESSGAKKQENGGEGIWCQYCQKNYSKQTVYDAHLNSKGHKKKAAEGAGSTASPAPVGPTTTTPQTSKSKLPARLTFLIIALLTFPPIPRLLSDSRNEVERKMALTSREREQEIEEQEEGQQVEEVELGNDSDEEDDDGKVYNPLKLPLGWDGKPIPYWLYKLHGLGVEFKCEICSNASYNGRKAFEKHFTESKHAFGLRALGLPPSKHFMYITKISDAMSLAEKLKREGRQELTAMDKAEEFEDDEGNVYDKKTYEQLQRQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCC7</accession>
    <name>A0A1E3JCC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032369.1">
        <property type="nucleotide sequence ID" value="XM_019175879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCC7"/>
    <dbReference type="GeneID" id="30192966"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="866" mass="94024" checksum="602F5A007D635684" modified="2017-01-18" version="1">MPLPPLHSLPLNPTTGQQPHPSLTTRNSGHPPPAGTSTGGVSRETLKALHDVYWSDDEDDPDCLLCAEPLDLSDLNFKPCQCGLQICQFCYNKLLSSDARCPGCRRTYDTKAVVFQPVDWEEVKKAKEKKAKKAKTIKQLTGTGRRHLLGVRIVMKNTAYVIGMKIPSPGDEALSILRSNDYFGQYGKISKLYLADSKAVSTAVPSIGDDSFAPGIYIVFVRREDAARCISSLDGIPAPQGPPGATLKATYGTTRYCEAFLKGMKCDNSGCHSLHEWGGESDCFTKEDLETAFTRPTEYDARQKQASQSTPSQSVPSLMSKVAWPKPSGDDSQSLSSAATGLPSAASWGKGIGAKIPSRVGPPGPGAISRPTKISNVLPIKNNAAFPLPTPSPTIPIIIKEKKEKKSSAMARARSTDSSAPGSAQTSPKRKVPALTSSKPTAVSIPAPTSSKSPPAPVPVSAVPPARESSPVFAPESPEGYADEHMSGDSDAEPSSDSPAPQTPSRMADSIPPQPLSDEPFIIHSPYPEPIIFTFPAHDKDFAFVLGLDDEELQRVQAQAEGYEPSPFSKTLEGLAELGVHAPEVPELFTPLSPRLDHYSGFFRPFEADENSPALSDNTPGPSEQLTDDHNAQRTESRFGFARATGGSTRTQSPFRRGMSDANMRDGWYRNEQQQQQQQPEANSHISSLAAQLAGFGGSYDSASGASVSGVTDSAWTNDSAYAPSPALQQRGQQQTQQQQYDVRSNGRFEQPLLPGQFMQKGMRDREEFDNSLLAMLQYGNSNQQQHQPIYTHQNQQSQQRAMFSPESASHSMHEEQGGPFSPLAYTQMQQAQQPQIHPDARQLMHMHQRRGQSPAPLGAHGYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCH5</accession>
    <name>A0A1E3JCH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterol 24-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032406.1">
        <property type="nucleotide sequence ID" value="XM_019175916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCH5"/>
    <dbReference type="GeneID" id="30193003"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="343" mass="38418" checksum="133FC35B25C427AD" modified="2017-01-18" version="1">MPADARSADRVSNYNKFWEKKPIDDNDTHRANRLDQYTDVVNGYYDGATELYEYGWAESFHFCRFYKGEAFLQALARHEHYLASMMHLKPGMRVLDVGCGVGGPAREIARFADVNIVGVNNNDFQIGRATSKSAKAGLSDKVSFVKGDFMKLSEQFGEGSFDAIYAIEATCHAPNFEGIYGEIFKCLKPGGVFGVYEWCMTDAWDPSVPEHKEIAHGIEVGDGIPEMRNLAAARDALKSVGFQIEHEEDLADRPDPVTWYYPLEGDLRKAQTPWDMFTCWRTSKMGYTITQNAVWFMEKLGLVPKGTYDVGESLIVAAKALIAGGRSKLFTPMALWIARKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEU1</accession>
    <name>A0A1E3JEU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032466.1">
        <property type="nucleotide sequence ID" value="XM_019175363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEU1"/>
    <dbReference type="GeneID" id="30192444"/>
    <dbReference type="OrthoDB" id="10507420at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="628" mass="70450" checksum="1EE2595EC517AAFA" modified="2017-01-18" version="1">MSDDEFNFSIDLPRSQQRCQLKARASHIWGELYNPDTDKYIRVRWDDPRLLAQEAEEEARFERAALEREKELEVERALRGDPLSMSLTQRLSRPLPASAGPADDDDGIVKAMRPVPVTQKQQDRMNLPTDALVEEAQEAKTVRLSKEQRNGMDAMFIVLRRIMCIWCIENDVTYTRAKSEFCNANVVRADTAWNLYQQTAEAEELRSEAKKALARTAVERREHGSVVARSKTKTSNVQSNSVGKSSAREDLDSDEEEEDDKEDGDTRSDGRQEGTEDGDEQDDDEQDGQGSNQGQLDRLGREEEGNDGDDDQPHFIRRAYKARQDDWREKNGLDPNKTDLPGFLESIDALPKKGDSTSDANNNEKLQRKSRLHDVNVFKDTVQRRMNQLEDKHQVSCFVFIASAHRQDERVQEIVRSQVAAAFLRSQKSVRPLPFLGEFASFLEGNKMARGDWASGARLEPMPSDLNVEKRRDHIQKTLTKQYSEVRSAAYRILHPMSTRQPSEQKTISWMCLEKHGVEVLTGSVGADLLRGLDSDGKRIKWSKEQCRVVWDEMDKGLIKFKVKNGLRAVKRGATDQGGRDAGGKRGKTVDREGPERDGGANQEGGEEGGVGEGGSGGGPGASASGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEX3</accession>
    <name>A0A1E3JEX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032507.1">
        <property type="nucleotide sequence ID" value="XM_019175404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEX3"/>
    <dbReference type="GeneID" id="30192485"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="37211" checksum="B671716184837F4F" modified="2017-01-18" version="1">MTAINGNGVTEKNVVLITGAGGWLGGILANALQSDPRTPNVHLILADIVKPKLPNSPKNALSITADLTTKEGVDALFQTEFGVPDTVYCFHGIMSRGSEDNFELGLKVNIDSIRLMLDSARHHKPSSGQPIKFVFTSSLAVYGGPLPAVVDINTIATPEGAYGMGKLSSELLVNEYTRRGFVDGRILRLPTIVVRPGPPSAATSAFISGIIREPLHGVKAICPVGDSLESKELELAAWVASPETTIKNFVIAKHIPAEKFLPHTRVAYLPGFTVTVREELEALAQVAGKQALDLVTFQDDPINRRIVGSWPARFDNAYPRSLGFVVDEGGMVPVVQRFKEAVAAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF33</accession>
    <name>A0A1E3JF33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03334</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032567.1">
        <property type="nucleotide sequence ID" value="XM_019175464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF33"/>
    <dbReference type="GeneID" id="30192547"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="254" mass="27288" checksum="09FC4BE995A06267" modified="2017-01-18" version="1">MAPPQFLLDHLPAPDAPLGRPHVTVTWAQSLDSKIAGPGGQRVLLSGPESMLMTHWLRGMHDSILIGVQTLILDNPRLQTNLLPPSHASPPPQPLILDPSLRFPLDSRILHEWNSKPALRGRILKQPWILCGNNVARDKIEMVENAGAKVVTVSLDSRGHIPPASLPGILTQLGLKSVMIEGGSRVLSTFLHSPRREDGSKLVDSVVVTVAPMFIGQGIGGEDKGLPALQTIHTETMGKDAVMICTVDTSAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF71</accession>
    <name>A0A1E3JF71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032605.1">
        <property type="nucleotide sequence ID" value="XM_019175502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF71"/>
    <dbReference type="GeneID" id="30192585"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="113"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="24238" checksum="ED696F20AA6A83F8" modified="2017-01-18" version="1">MMNLDEEVRLWTTNTERERTENMATLYSIIVSLEYLERAYVRDSVTGKEYAPACIKLLAQYKSLMKLLGEDVGGVEMFMTRFKMEHPAALHRLTVGVPATVEHSAEAEEGGAERGKWVAETTQSFITFMDALKLNLRAKDQLHPFLTELMSGYSRFKGSQEWEGRGKILHWLISLNAMKASDEISEEQSRQMSFDIENAYNEFFRSLSGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFG9</accession>
    <name>A0A1E3JFG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032502.1">
        <property type="nucleotide sequence ID" value="XM_019175399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFG9"/>
    <dbReference type="GeneID" id="30192480"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="126"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="482" mass="53572" checksum="59A86BCB2293D81C" modified="2017-01-18" version="1">MAPSSTENAPKNLEELKQLLKDDTKVKVAGVDVEGVLRGKIMSKSKLLSSVKSEGFNFCSVIFGWDIHDQTYNKDLLVANWDNGYRDLLAVIDLSTFRRLPWEKNVPFFLCRFVIPETGKILPVDPRSLIMDVTEKAQEKGYKCMSGAEFEYFQFAETAQTLADKNFRDLKPLTPGMHGYSVLRPSLNMEYFHDLYDSATDFGIEVEGHHTETGPGVFETALGYTDAARMADNACLFKLVAKSLGMKYNISPTFMAKPWGDLPGCSGHTHVSLQDKDGKNIFAVTDEEAANGGRANAAFDDVKYISQEAEWFLAGLLEGMPDVVPMFCPTINSYKRLQGGQAMWAPDTASYGYDSRAASVRLITAPGVKGYATRFEVRVPGADMNPYYTMATIFALGLRGIEKKTPLPYGPIGSPGVTRETVKHLPTSLESATKAFMAKDSIAREVLGDFFVDHYGGTREHELDLHRKAVTDWEVARYFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JH83</accession>
    <name>A0A1E3JH83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032543.1">
        <property type="nucleotide sequence ID" value="XM_019175440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JH83"/>
    <dbReference type="GeneID" id="30192523"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="414"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="583" mass="64662" checksum="A74418E87E1EB742" modified="2017-01-18" version="1">MPTVSVLPAFLQLGSPPRSPHVERPSFLSSVFVPRESPSTPRGSPSMKPTRRDVLLCLLTLSFSYLLFSSPPSSDPVALSASGGNRYRIPGWSNFFPSSTGTSRSHDRSGEVLFTDSVKAVGVGSADVEFGKGNSWDGGEEEEEDDEFESMATVLKGHSPGWTMFEKLYIYNGSFYVITEDKEKFPELRLMTSTGLPANNEPGNSEAREPKGDEIIYISPMDAAKLWGPRVYRMDGTTFLFNDGQSVIDHYYHFAAELLLGIWRTYTSYDQDISPAGETSLLAPKRMWFLHQSVDEWRDNPRFNPLLMFNLFPQTSLLYPSDFADLAKQSVSSKPKAFVLDRAILADRSAAFRGPFTGPTARTVAGALQVGEASRWWWEPVRRTVLRYAGVPQSIISRNLEGYGAVDPVTLNDPTIEPIEPLAPPGDYAPVITYISRQNSRRRLTAESHAGLVQALEERAERLGWELVIVEAEKMTKEEQFALAGRTTIMLGVHGNGLTHLLWMPATPRSAVIEMFIQGGFARDYQWTAHALGIRHFGIQHDISFTSPALPEVDYPEGFQGTGITVVGKVVADLIEDRLAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHC3</accession>
    <name>A0A1E3JHC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032583.1">
        <property type="nucleotide sequence ID" value="XM_019175480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHC3"/>
    <dbReference type="GeneID" id="30192563"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN99506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="108" mass="10762" checksum="AB83156585BCBC15" modified="2017-01-18" version="1">MSSELAATYAALILADEGIEITGDKLITLTSAAKVEVEPIWATLLAKALDGKDIKDLLTNVGGGGAPAAGGAPAAGGAEAAGDAPAAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHQ2</accession>
    <name>A0A1E3JHQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032528.1">
        <property type="nucleotide sequence ID" value="XM_019175425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHQ2"/>
    <dbReference type="GeneID" id="30192508"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000327">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000639">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="684"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN99451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="84889" checksum="7E1FAEFEDC93EE54" modified="2017-01-18" version="1">MADRDVRDRAPRVRNRAAAAVQITAEQLLREAQERQEPGVQAPKQRVQDLEELSEFQARKRTEFEGRIRYSRDSIMAWVKYAQWESSQNDFDRSRSVFERALDVDPRSVDLWTKYTDMELKARNINHARNLFDRAITTLPRVDSLWYKYVYLEELLLNVPGARQIFERWMQWEPNDKAWQSYIKLEERYNELDRASAIYERWIACRPIPKNWVQWAKFEEDRGQPDKAREVFQTALEFFGDGEEEVEKAQVVFGAFARMETRLKEFERARVIYKFALARLPRSKSASLYSQYTKFEKQHGDRAGVELTVLGKRRIQYEEELAYDPTNYDAWFSLARLEEDAYRADKEDGSEDANPTRVREVYERAVANVPPAIEKIYWRRYIYLWLQYAAFEEIDTKDFDRSRDVYKAVIKLVPHKSFTFAKLWLSYAYFEIRRLDVTAARKVLGAGIGMCPKPKLFTGYIELEMRLREFDRVRTLYEKFLTFDPSLSSAWIQWTQVESAVEDFERVRAIYELAVQQALDMPEVVWKAFIDFEAGEGERERARSLYERLLERTSHVKVWISYALMEIATLGGGEDEDGNEIEGEAGDAEAARQVFERGYKDLRKNGEKEDRAVLLEAWKTFEEEHGDDENKETVEQMMPTTRKRWREAEDGSGMEEYWDLIFPDDEKEANPTTFKFFQAAQEWAAKRGTQGEESGGLSYDMPSDSDDDDDGEAGEGEGMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI82</accession>
    <name>A0A1E3JI82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032786.1">
        <property type="nucleotide sequence ID" value="XM_019175054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI82"/>
    <dbReference type="GeneID" id="30192127"/>
    <dbReference type="OrthoDB" id="10477998at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13387" checksum="B5A099A7841ABA96" modified="2017-01-18" version="1">MTPTHTVNIAHAERVIMYDNNKKTREIRGAKDIRLESGYTTAQKDKKAKDASKTAAVAAAVALANKATKHKTVTHTAPTKAPSSSKAKTATVTPAPKTKKAESNKAEHKGQRRRLGVYFEETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIR2</accession>
    <name>A0A1E3JIR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 25 (Mitochondrial iron transporter), member 28/37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032728.1">
        <property type="nucleotide sequence ID" value="XM_019174996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIR2"/>
    <dbReference type="GeneID" id="30192068"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000172">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="53"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="264"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO00536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="39094" checksum="153D0887F197AE3E" modified="2017-01-18" version="1">MASSSSSPSSSLHFQPHGVHLDPHSSSPLPHGESSVALEEEEEHDYESLPVGHGWATNMAAGALAGISEHAAIFPLDLVKTRMQVLAPLTHGLSLSSSASSSGTAAAAARSAPPPQLNTILSHLRSISTTEGLRSLWRGVASVILGAGPAHAAHFGMYEFVREVSGGRNEGWQGVGGTALAGAMATVSSDALMNPFDVIKQRMQIRNSPHRTVLSCSRTLYATEGLSAFYVSYPTTLTMSVPFTAVQFTSYEYLKTVLNPSGAYSPMTHVIAGGVAGGLAAAVTTPLDVAKTLLQTRGSSSDARIRGARGMGEALRIIWERDGARGLRRGMWPRVLTVAPSTAISWMSYEFFKVLIRQHGELPEFGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM29</accession>
    <name>A0A1E3JM29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033162.1">
        <property type="nucleotide sequence ID" value="XM_019174783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM29"/>
    <dbReference type="GeneID" id="30191852"/>
    <dbReference type="OrthoDB" id="2561841at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="39543" checksum="1E6B82FEB4655322" modified="2017-01-18" version="1">MYRRPNLKEARLKEALESVWPDYAITGRKPEPFPLPTFPIISLDALYPVHPEILDILFFSSPKTYMLLSKKHYARVIPLFWRLVVLTEALINAIKRKDSRVLNHLQHMVSVRIGSLESINALESMSSRLSNGDVFRKVTQVEFTATTFKRCWTSGPLLQIDVGSIEDCLGDNLEELIIRISRVPSKKFTLYQAAFTQLLGSLPPLVTMILSLPNPHAPSWVDFLERFPELLRHWTLPQCLRIVFKIPEQMTSLVKVGVENAIVKHIRTRAIDTAREPTGGAGGKRVEYHFSGAEEMESRISAKFAGNSILNQQILKDFEQKKYRLVELPLHAFSYKKDGTDMAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM30</accession>
    <name>A0A1E3JM30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033156.1">
        <property type="nucleotide sequence ID" value="XM_019174777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM30"/>
    <dbReference type="GeneID" id="30191846"/>
    <dbReference type="OrthoDB" id="10382503at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="31026" checksum="B29EF7C0FE5A3947" modified="2017-01-18" version="1">MSKPTGRARRALSSVADTLFPGSRYPDPRVTHPSAKTGADELVIKMHSLISLSNFQETEYWNTDFKGTKEELMTKSYYTEPYIDPDIEILEEAPTSVNEKTQSQQAGTSASGGATDILPISTDPSNATGPPRSRFEGEPLVPTQYHNPHLDYHDPWPRFPLTLAARSVGADRHHMFPRSALSFDVFDMANSRIPTDPEVEEDWVLKVKSNVIIPGTLRSVFDVKEASYFEGLQDAGERWKLDRVKWVGHGSSMGRDNVVGCWYSPSESDWVFKRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG5</accession>
    <name>A0A1E3JMG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033307.1">
        <property type="nucleotide sequence ID" value="XM_019174928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG5"/>
    <dbReference type="GeneID" id="30191999"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012814100" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="257"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="479" mass="53820" checksum="7EA65ADA73801EF8" modified="2017-01-18" version="1">MVHLASLLFLPLALAAPAQDIPELSLNQWKGIQNGLTNRISSLGSWSWNKAEEALSDLGGQDKTELTIWQNLKEDPHSFSKLVNIIEFEGHASKYLDDKDAQITFFAPNNDALTPPHHEDDDDDFEQLLHNPSLASLSAALDRDPSLTSSSKGHDDDGDEEKKRKKEIFRKIAGKVLAYHGLPKAYTVQELGQNSTFATALKADDGSYAGLHRRVRIEKNLVPPSIRLNFYAKIVASDRKARNGYFHALDHPLLPPGSILEELFLFPDTFSTLTSSVQKVHEAHALDYGYDREHSEPGKPKFYGNPLATLFAPSNAAFHDLPDKLKFYLFSPFGEKSLIKLLAYHYIPHTLLLSEAFHQEKHEHKGEVLTVGNDPSFHKQFKIHTGLPNATVEVEIEKVKVLPIEGATKTTIKVNGEQVEVIDVPARNGAVHVLSKLLVPPHEHHGHHGHHDHDQDLSAEDSWENWEEWFPQWVEAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JQ48</accession>
    <name>A0A1E3JQ48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flavonol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033294.1">
        <property type="nucleotide sequence ID" value="XM_019174915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JQ48"/>
    <dbReference type="GeneID" id="30191986"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO02042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="43968" checksum="E636CD44AB88F7B5" modified="2017-01-18" version="1">MPMTPKFNPPPTDLPGKPPVKTWVPPPITQETKGFAALTSIDLSLLDSDDPVVVDNLVQEVKRAIREDGFLFLENYGISLEQLHRQFSLAQYLYDNITDDDKKRLLFYPETGLWAGYKHPYGFKRHQGPKDGIEQFNWYTNEWNDYSRYLTGSVNRRLLTLFSRVLELDDDYLWDNVQSQGSPTGEGYFRHALFRPVEKTTEEASKGLRMHGHTDFGLTTLLFSLPVSCLQIWGKDEQWYYVPYKPGALVINIGETLEIVSGGHFKATRHRVYKPPADQLKTERLSLVQFNSSVGDLRMTPAAKSPLIQREGCVEEQGVYKEFKRVMDLGVSVPTNQQWREIQIAEATDPTDTERNRVGSDQVVVNGKLMQTREYYGVKVLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR43</accession>
    <name>A0A1E3JR43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033400.1">
        <property type="nucleotide sequence ID" value="XM_019174348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR43"/>
    <dbReference type="GeneID" id="30191408"/>
    <dbReference type="OrthoDB" id="2565314at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="63569" checksum="64C5B5E4799B88C9" modified="2017-01-18" version="1">MPIAQRPPTDTPHTPPRRVPRPLAPPGQPPSPDHPRGQVPPPAPCSPYGRTLAEAYADAHSHPHPSTSRTPSHGAWRPDGHAREKKPIFDWITRKLTTARRTTVSSHSTQDAAGERREKRSRLASMPRARGLGLSNTPSHDSQRKREISMPAMTRADTLPSVSFSLDSAANTVEHDRRREANNPYPSLPLSLAAGHNRHNRHLDAGAEDTTGMSMFSGTVSLSGEGSMRETEEEGGNYSRRSSRSAPFERDTHYSTVSGHGGSDWPADDDASLRPFPPSARGSPTQSSFRSPSTSVLYHKRLRASTLYSASSDGADLEGGRDNEDGDAEDGDESSGRGVGRRRISRDGSTSTKPTTCISYDSGLGVAHIAHASTPPAAPSTASHTTPVFPIISPPVSPQPPPIPNDPLVHAPTHTPHHPSYNPHPSSSPDPNASTLTLASSSFALPAPPGQRRSDRPSSLVTSPSIITWAEPTSAPLSPPYPATGDRPLSVRTSNSYAQSLGTGGGHLSLHAPSISMSLRGLRGIGGAGPSGGFDGRADGDASVRAVRRKGSWESNESGWSWRGAAAAAVAQGQGPASVTERDGTELERVLESPRVIDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRE9</accession>
    <name>A0A1E3JRE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T cell CD4 receptor C-terminal region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033509.1">
        <property type="nucleotide sequence ID" value="XM_019174457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRE9"/>
    <dbReference type="GeneID" id="30191518"/>
    <dbReference type="OrthoDB" id="2575893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021963">
        <property type="entry name" value="Tcell_CD4_Cterm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12104">
        <property type="entry name" value="Tcell_CD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="T cell CD4 receptor C-terminal region" evidence="3">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="774" mass="82561" checksum="8A6EDC1355384D1F" modified="2017-01-18" version="1">MVVSASSQRDGTSTSKRDVTLKMTDSSPFDSARSTSMTAQSSVIGSQTEATTQASPVDSVSSASRQLDPTQSSESFGQAPISSEVSSASQIRSQSSMTTTPLSSPTTSTFSTTASASSAATPSTAPSLSLRAHSRRQWRDGDGSGPGETQQTCQTTTASTIITYSSSTSWSTTYITSISTKTVVVPTQTIWGGCESTSSTEWAEPTSSSWADGSAWTYSSSEEGYWVESSSSSESDEWWSSSSSWTEAWSDSASSIPSTTDDNSFIAAISSTTSTTATLTSHGPTTISLSTQSPTSTSSTTPTSTISSSAAAVAAASDAATSSTTTASASTAEDNSPHINKSVSIGAAVGGVFGLFAFFAMCLYAVRWWKRRGRVQRTAELRSSWFYGGDVRESKMYGTNEKGFEHGDAESQLEPEAQLPQSRFSAPSLISHSAIPALLRQPISHIRQGSGRFPPILSLKHLRLGWNPDQTARKENGNGTGTWVDKYTTPPTVNSTRSRSGLSRNVSPPRAMEMDSPLESTPTRPRRPDGTVSDHAPDTGVTWGASYTSPTVAQPHHQQWEHGQGLEAEFDHAALSEASHSVYSRTSTYTQHGNALSRGSTLKSMQAGGAGGANEAAATFPMPPVDHPFLHSRSSSNIQTERSLPPPPLPEIPAITFSPNFSHPVSQDYSITRSTQHSSGVWEYSGYDDSSRHTPLSGTLQLSREAPLIQGGVDDEYRATRDWYEKSIWDGGITESSTVPHRPEALGHSSRKSVKSVRWGDEERDLQDGVPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTV0</accession>
    <name>A0A1E3JTV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033598.1">
        <property type="nucleotide sequence ID" value="XM_019174546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTV0"/>
    <dbReference type="GeneID" id="30191608"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130560" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="299" mass="32456" checksum="170B282148BCFF74" modified="2017-01-18" version="1">MLTTHLLLVLSVLLLPASLGRPTPPRPASRPDRRDGRERDIFDNSWFACPDSSNTQTFYKIERWGLKRECFCPGQYQFYNSFTRQCHCAEPFTPSYSLSNELQCSAHQPPLLDDSQAPEAALVFESSPVEDQNLAIPQHDAPTPSPVLKRPVAGAVVGKGRLFGGTRGGGRGSMRETSGWRVEGGAEEMDEDVREMAGKTVCDFGEKLCKVGGGYSCLDVMNGLSSCGGCPGEQGTVDCTSLSGVSEVQCHAGTCQVDSCRSGYQLEYDPYPDAPSTSSCVSTSNRSKMPWFSDVKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUF4</accession>
    <name>A0A1E3JUF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033603.1">
        <property type="nucleotide sequence ID" value="XM_019174551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUF4"/>
    <dbReference type="GeneID" id="30191613"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22944" checksum="7B317B60F564AA82" modified="2017-01-18" version="1">MPRKLLYSFAQFYNSNFERRPTATLIVTNGVLNSVADILAQSSSILLHKPTVQNPLPPTYDPTRTLRFAVFGMAMGPVIGRWMRLLEKRIPMPNVSRGGGLTLPGGVVRKKGGEGIQLAKRVLADQVVMAPIGLCLFVGSMGIMEGHSQLEISEKFRDVPALFANWKIWPLIQTINFKLMPIQYRVPFQSTCGIAWTLYLSLLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWA7</accession>
    <name>A0A1E3JWA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033789.1">
        <property type="nucleotide sequence ID" value="XM_019173982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWA7"/>
    <dbReference type="GeneID" id="30191035"/>
    <dbReference type="OrthoDB" id="2595432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="28454" checksum="0A65399D41CE4AC2" modified="2017-01-18" version="1">MPPAPTRPPSGKTHVRAYQACQPCRIAKLKCNLGDPDAPHDPPCDRCHRSGRQCVFGKPYSRPKGLVRKKRESESVAKSPVASTSSATSRPSALDRIHSSTPLSRHPASDHGMSQDFRFVRGETLENPADALRILYAAAEYDASHERSESATSGEGPSQAGLWARWIPVRDGLLTAEEAALYKDHLNPCHPVVPNELFHSQNFSSLLSEPILLAALVSTAARYLDLGHSFDEKEPQRSNVIQGKLMNWVSSKIGLLSMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWL9</accession>
    <name>A0A1E3JWL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01882</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033848.1">
        <property type="nucleotide sequence ID" value="XM_019174041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWL9"/>
    <dbReference type="GeneID" id="30191095"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="333"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1235" mass="131017" checksum="BB7B12576D429616" modified="2017-01-18" version="1">MSALPTTTLLVANMHCTSCCDAIDSLLATLPPVRNVSTSLLQRTVTFSVDTNAAHSSSKGPPSVPRVIDQVVHKLTGEGGFAIEADDEAEHPPAREAPSLLGRLGLQTRRGRERKRAEDRRRRHLEHCEVCQAQEREQVERSSPLSTPSHSLQAPLAPQNASQHDGIVKTTLSIEGMTCASCTSAITNALNDNPDIEQVDINLLNSSGVVRHKALLPATDIAEMVSDIGYETEVVESHSETSVAPSAPDSQVKTVLSIEGMTCASCSSAITDGLSKHPNVASVEINLLGSSGVVLHNQSLTPDDVKDIVDDLGYDAQVVSSETAVERKRDAKIKSTFAIEGMTCASCSGAINSAFRGMEGIESCDIDLLNNRGVIVHASNITAGDLAEQIEDLGYGAEISTSEPVSLQSKGKDKEETLQRTVKIHVEGLFCHQCVSKINHHLSTLPLLSHSDIALHPSIITVTYVPHDPLTIRDILEGLTGLAPEFEASVFKAPSLSERSRDIQKKEVRMLARHLAVAVVFAIPTFVIAIVGMVLLKGHDAFKMKMMESTWGAANLGTVILWPLATVVQFGVGRRLPKRPLTWRSAFSFGSMDLLVVLSTTVSYFASIAMLAIDVQNPSGTDSVGTYFDSCVFLIMFILLGRTLEAYAKSRTTDAVSLLGGLRPDTALLVGETSHSTDGSPGSSATPQSRKIPIDHLEIGDLLLLPPGSLPPTDALLVSGTTTFDESSLTGESKPIHKHPGDEIFTGTVNLSSAVTVRVLRLGGDTMIEKIIRAVSDAASRKAPLEKLAEKLTGVFVPVIVYLSLIVLAVWLPLALTNTVEPHSVAGGKVFFALEFAISTLVVACPCGIGLAVPCANAVGNGVAAKAGILASGGGEAFLGATKISRVVFDKTGTLTVGRSEVMNEVWEGAASGDKENRQRILKGVLELERASTHPLAVGMVEYLEKSPLAPSGERVEVVDTEEIAGRGLKASLRIGQISIDLLVGNVALMTDHNVEISEQAHVTVSTWSTEAKSVILIAMSDAPGSYALSALYSLSDHPRPEAAEVIAFLRKRGIAVNMLSGDNETTARAVGKMVGLGENEVKGGVGPKGKAETIRIFQAGEGANEKMQGKDESRKDVVMFIGDGLNDAVALAAADVSVAMGHGSQATLASADFVLLSSSLNSLVPLLRISRKVINRQKLNLGWAIIFNVVCLPFAAGVFYGAGKIRLTPVWSAVLMALSSVSVVCSSLAMRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWN2</accession>
    <name>A0A1E3JWN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033926.1">
        <property type="nucleotide sequence ID" value="XM_019174119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWN2"/>
    <dbReference type="GeneID" id="30191176"/>
    <dbReference type="OrthoDB" id="2575946at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12146" checksum="229BCB83F327F300" modified="2017-01-18" version="1">MAAQEHKAEASASAQPSSSSTPAPAAVDKKASSAQSAKLLKNSRLPATMITAAGSIQASQKNKANKGQMSKKKKARTEKGKDRAAELSSRLEEKVRGREDRKAKRQRAKKAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWP9</accession>
    <name>A0A1E3JWP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033946.1">
        <property type="nucleotide sequence ID" value="XM_019174139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWP9"/>
    <dbReference type="GeneID" id="30191196"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="116"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="38896" checksum="DB49D924D09266FF" modified="2017-01-18" version="1">MADPAPQDANLSPKAAAQDFNQSEHQTSEHQLSLRSLVSTKEAGIIIGKAGATIAQIRNDTDTKAGVSKVVQGVQDRVLSVTGDLEAVSSAYAEVARLLLETPLSDSSLPPPPVGSFTSIRLLISHNLMGTVIGRSGLKIKQIQDQSGARMVASKEMLPQSTERVVEVQGSVDAIKTAVLEIGKCLLEDWERGAGTVLYHPGAAGDAGVLAGGLGAQAVTGSTGGIRRTSVAAGFGGAPSGGAPAGFTDRRVSRGSISGPSGAPAERRQSEAPQINLNDPNLRTQNISIPSDMVGCIIGRGGSKITEIRRLSGSRISIAKVPHDETGERMFTIQGTPEATERALMLLYSQLESEKERRVNGAAAQDGSITGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWR3</accession>
    <name>A0A1E3JWR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033895.1">
        <property type="nucleotide sequence ID" value="XM_019174088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWR3"/>
    <dbReference type="GeneID" id="30191143"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="35407" checksum="A4C29A50CC7F7E6D" modified="2017-01-18" version="1">MPATYASTNINGHGSSSAGPSNGAVEDIDMEDDEAPVGDLSDDEEGEEEEEAGWTEATFTDKPISRAGASVVRGLSDAMRDAIKRLDDVVDSIKETAYILEEAVADDPALKNVEASLFKAFDQRAVLKIKANALDELSKRLLEGREHTNIQADFENLSEPRIQEYKGKSQHAKFKKDREYADFKSELWSRSHETACPPISTFLTKGPNDEDDSDDDIDMGGQTQNYRCPITLTLYQDAVTSVKCNHTYSKEAIINLITNSQKNRGVARCPVTGCSIAISKADLKDNPAIQKRANDFSRRQQEKEDDRDDDAASVEDDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX33</accession>
    <name>A0A1E3JX33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034079.1">
        <property type="nucleotide sequence ID" value="XM_019174272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX33"/>
    <dbReference type="GeneID" id="30191330"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000056">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10558" checksum="45F643F62DAAB833" modified="2017-01-18" version="1">MGGRKVMVQPINIIFSHLQKHNRVSVWLYDNNEFRIEAFVVGFDEFMNLVLDDAEEVYDCGAKPGKEVQPRRELGRILLKGDNITLIQPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXA3</accession>
    <name>A0A1E3JXA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034041.1">
        <property type="nucleotide sequence ID" value="XM_019174234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXA3"/>
    <dbReference type="GeneID" id="30191292"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="731" mass="81652" checksum="2787CD7482F38763" modified="2017-01-18" version="1">MDADEQVSEEEYKALLSEHRAWQLVRSIYENKIHRADPGYELPDSARQIVENPYTSPEELVQSMIVEDPELSLWATLVEHLQTRPLLTASPYLEIRHGYLPSTLRQARTNPQRPSSLDPDFTLRDSQGAALAGEDQTYQPPFLDLLFNLVRYGELENAIKVCEQCGEPWRGASLMGVRRWAMGGMVEGSEPGGMTGNRYRALWKKSCRTIAKNHTLLPAERHLYAALISDLPTLLPACENWEDYLWAHVQHRIEARLEKRWHELGGFWEGEAGVGKDQAEEVEMARGGLEEVFESMRGVGKAGIADEMTDPYHVAQQMILLGRTDALFHSFADQIIDLGEAMAPELFSSLLRFFTHLAIVLRTLNQPVPPSAANIIIQAYLSVLEKEGNDKLVAMYAACLREGSGEESYARFLWSMDPSASKEARSEALLRAQTHSLDTALIARETVRLSLEEAIPTSLSTAFVEPDILPLSVGLTERDVGLIRSIEWLTFIGETGEDVVVLGNQLVRFFLSQGQANAAQSLLLSLPSLSQEIASAAHLRTHLLELASYNRLFTLFTSYTSLSDVILRKPLPTAGKVQVHSWRKDVGEAVEEVWKGTVGLVEDGWLELPHAETDDEEDEGEGEEERQRQLKLIRHIFIPDLILRLHSTLIAQSSLFPTYLQKALQLATIVADAKYRVYEGFLPLSATSQGAGAGVGREKVPRLEVYLDKMREVALEALKSGSGSAFRVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYE4</accession>
    <name>A0A1E3JYE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033882.1">
        <property type="nucleotide sequence ID" value="XM_019174075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYE4"/>
    <dbReference type="GeneID" id="30191130"/>
    <dbReference type="OrthoDB" id="2566935at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130628" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="16676" checksum="44C29E0A1F612C17" modified="2017-01-18" version="1">MLTFSNLLLILAIAIFSLLSSTLAAPIEHEPEILQPKSFITQESNAYPPLRFLTRFRSHIPPDTKVQLKWAGGSGEGVEVYYIPQWPGQEDYAPIDILPPTKDTTSYVWHTPSQNAYPEGTTFIVGINDVIPNIGAVWYDITGLLSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ21</accession>
    <name>A0A1E3JZ21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034159.1">
        <property type="nucleotide sequence ID" value="XM_019173454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ21"/>
    <dbReference type="GeneID" id="30190501"/>
    <dbReference type="OrthoDB" id="2576334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="961" mass="101064" checksum="B745FE99458E0B77" modified="2017-01-18" version="1">MESLSQGIVKRDDSEAAFFISDSSPLFKYSSFSSSSSSSNMTNPWTAAYARQTDGYDQTLHLTSSNHSIIEFNITSMSLTLLVPQIEGCSATVSINGTTPVPACATSSSSSSEIPWRLADLDYATHSIKYDSGLIPSSSSSGEGGQVIFWGVQGTRPGTEGGGRGGGTNVTVDDTFFRPSSSSSSSSSSSSSSSTATDTDTEEEAKVSITYSPFWTHLSKTSLTSSSLSEMGQLEGDFNGTLSVSQEAGDWVTFWGAGEAIYVYGTVGPDYGSARVELDGAVVVEGMNLTSPWTMQYQLLYFQTNLDPSVATNLTMTNLGGSGGEKMSLDFVILTAREDVLDYLSTPSSSKPFTSTLGGKLILFMLLPLLVVLLFSAFTWWILLRRRRRNARRSRSPPDAGAGISSWVPWTPSKEKRAKARGGSRPWRHSQDSSSTSINNTTGGKAKRKYWLFPGTASSSTGGRGSPTNSLDGEGEDVFVSYDEAKLQRMSGKWSSSSGSGSGGAGRSPVSGRGGRFTPGLAAAGWGLGTVEEDERNEGSVSMRSGRSRSSSRSGWSGGNGDRKRERGDDRDIMSVLDRTYATPNISSRRDTALPAYTPSNDARTNYTYSTAPNSHHTTPQALNRSLPASSPSSATGTGGAAGSPESQFRSAEEEKAVQLRVMRDVAGGQGYSPPRLDLALPGSGPGPFTPLPTPPISSLPHPTQSLPRPAHAHHAHQASRGSATTIGASDIISIFGAPAGSERRMSMMTDHTGHSQFYSRPGSVAGDVPPLPTSSTYPGWISGSVTPVPGGGGGAVRPRIDTDLEKNPYGLPHMSHGRDASGGLSAMGTNSNMGLMGLTPSGYESATLSGLSGTSNPWHRTLNHHTSQTPLLPPSSSSATPSSPPNSYPSPQSHARPSTAPSQTLPLVTSVTTPNSAQHQRSQSTFSHMTERSAARPDSEVIPFESFISSLNAAAAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ80</accession>
    <name>A0A1E3JZ80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034288.1">
        <property type="nucleotide sequence ID" value="XM_019173583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ80"/>
    <dbReference type="GeneID" id="30190633"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="478"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="681"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125945" checksum="CC7F79DB39C54B7D" modified="2017-01-18" version="1">MSTTADYIAKCPRRQALLETVETYWLDDPRRPPGTLDSSLKKHTTLINKLKSALLIGPSEVFAKDIDGLTLSKYLEEIVAAVVDGASKGRGDPEVAVDIIVHLHSRLAPDFLQQLLPLLLGVLSAGASLSLPLGKDGDKEKEKEDKERLAKQRPVLRIIAELAMVGAWEEGVVKGSAEIGKILKGLMTNDPQFNNLPLLSTFLKYFGRAYLGSKHNNETSNGSDATAEKQTKEELPEGVTELVPVEVQKKMRELFVGYFNTTSKTLVKGQIKLLEQDKRNHEAYIKSGEIFEDRQQAYEKMIRAIERLNAGLQTLADLLGLAPPVLPTAATLSKSGLQIVDSGSSFTVRNDGPIAGGIWDDEEEQRFYEDLIDLKEVVPSSLLGIKEKSAKEKDEEPGNAEEEQIEKQKAEEEELRKQLEQMELADSQAQPESEKQGNDAVNTGGDAEDIAEDSADEEAPTTTVTEEDGLQSGPAARLSALFAALPESNNREVVDKLAIEFAFLNSKGARKRLIKFLGEVPRQRTDLLPHYSRFIATLTPYMPDVAQGVLDILDEELRYLQRKKLIRELDSTRLKNVRFYGELAKFKAAKPFNILHVFKVFLDDFKFNIDNIANLLETCGRFLLRNEDTAEVAKRMVELMRRKQANAHLNQRQTLMLENAFYTCNPPQRVAREVVQLTPMESFIRHLLDEVLMKRTIDKVLKLLRKLHWEDPEVYAYIFASFTSPWEIKFGNVPHLADLACHLQKWHPEFGISVVDEVLENIRIDLEENIFKFNQRRIATMKYLGELYMYRVISCSVVFDVLWSLLSFGHADPTSYPGRESPVDAVDDFFRVRLACTLLDTCGVCFEKGSQGRKLEQYLVMLQLYVTCKTELPMDVDFMLSDTLEALRPKAPRLRTFTEAATAVDELLASYKDFGVEEDGSDDEGLRQATEDKPETPEQVHAELEGTVEDDDQDVDVVIIRDQAKPDEDDADERAAFDREFAKVLADTTDARRGEQRKTAPPIFDTAVPIMRKKADEAKARATREKEQEREQAAKEEEGRMQFMLLSKKAGKQQLRSLAIPTDSTIAVNSKTYQAQSKAEQEQLKRLVLQNERRLERSEVEDIETRGIKLRFAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZE8</accession>
    <name>A0A1E3JZE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01431</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034299.1">
        <property type="nucleotide sequence ID" value="XM_019173594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZE8"/>
    <dbReference type="GeneID" id="30190644"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="35"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO06199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="80100" checksum="ADAEACF677EA1B1E" modified="2017-01-18" version="1">MPQIFDDAKNALAGDAKYRQMQGFTQEQNDKTPLTTYFGTKVADTDQALKAGARGPTVLEGDAPDFHNREKISHFDHERIPERVVHARGAGAFGEFKLHTPLTGITTAKILNDTSKTSPCYIRFSTVAGSRGSADSVRDARGFAVRLYTDEGNWDVVVGNNIPVFFIQDAIKFPDMVHALKPEPHNEVPQAQTAHDNAWDFMSLHRQSTHMQQWIMSDRTIPRSYRMMNGFGIHTFRLINAEGKSTFVKYHWLPHLGAHSLVWDEALKIAGQDPDFHRKDLWDAIEAGAYPKWDLGVQLVKEEDEHKFDFDLLDATKIIPEDLVPVQRIGTLTLNRNPVDYFTEVEQVAFCTQHIVPGMDFTSDPLLAGRNFSYQDTQISRLGINFGDIPVNRPVCPFMTNQRDGAMAMTSKTNRTAYHPNRFDALPTTEPAQGGFQSYPEVVSGIKERKLGPKFQEFYAQAQLFYNSMSDTEKANMVSAYQFELSHCLEDIVIQNELNCMNEVDRGLAESVHATFPHLTLPAPKPNHGKKSEYLSQITGKNQVFTAEGRKIGIFLVPGFDYKLVEAILPALESAKTMPKIVAPTKGPVKSASGEEVTAEFTFEGCRSTFFDALIFIGGPDASYLPKLKIGRLTHAARESYMHLKTIGVLGNAAQWLVDIALPGDFGAQAKTEFTKENGVVFDPDNAKLQSAKFAEEFLDGVAHHRVWDREVAHIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZI6</accession>
    <name>A0A1E3JZI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034293.1">
        <property type="nucleotide sequence ID" value="XM_019173588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZI6"/>
    <dbReference type="GeneID" id="30190638"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="941"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1201" mass="131803" checksum="60E79F887C84164E" modified="2017-01-18" version="1">MLKDIVEHPSADPTAPSIPQPPQPPAPGGTGFPVPLHRSQRPSAFARARKAQQDRQTTGKQAVGFGTAVESVPAVQVDKVEKDVVGGLNGPGNASGSEWEQVREQVNEENKRTLEAMTSKERSEEVEELRERFGSKTMGLMQKRADARQNKTSLPQASAPSLPAVLEPVAGVDTKSILQEVSEENEKRIKDMSAEERTQEMEELRERLGDNVLEGLRRRAEARLGKGKQREAEQVIKSKVHTSTPPTAEVDPKPKFHESAKLEWLKPITTPSNDSSTRFDLSGAVLSTDAKASLPTHLGLHHHGESPDLAGYTLQDILYLCRSTVPSQRITMMGVLSKIIAKLNNSDLSQEVTKECEKEGIVQQAIEMGIDVLAGLTRGAGVIRASVDLLFEALGGPSWSWPDDSPSSDTYQASIPTPLSANADPIGIASIPFDDVLPRLSELLSMPDALPPTTTHQLLLILRRATLLPGEMCETLCPIVPVVIRHHVVQRAWPPRPDNSPSTDAIRFLRSITAGSRACAEELLSERVYETILKFVVTATWGEESGVEAELGQLLAFEVLRIYGALGRYGLSASVVTSSGEVWRLFGAWVRERLATQSSPLEQSLIEAYFNLLSIWTTCAIDPHRTTPEHDITWAQVSALSWQDEVISAAGELVKQTRLGEMAAALSMLVSWTGGAKVNGARAGEEEKHELLESLRSIGLSESIEKLSSGNEEEVKVCAAAVRLHTQLQPVGMLLNEEVLATLRHAFMVPTKSPQRSVTYLRHGLLRLGMQDKTLSSSDWLPIALDLFLSFQIGDEPLALELVDDILRSDWSSSAEPIARQYASLAHADRLEILRPLLHFTILPDVEHVIAPREPSHIYLKATASLRAPPATVEGEKGQSIVGLPLQADWLFSPLNELLRSGSSSALAQVPPDWSASETEIVQSVLLLGQLQCAVTGWEDRLGRSRVAFNMMKVFMLEHGQQGATTTSESEVFRDAQVALGMSRLMAHLTNPMTSSGSLMTPIESVSLPFLGAGVPFFQFYTDFIALYEAISFSDLLFSQLLLPPLAMSYPMDYRKLLWNDHATALRGMRMKMDGVPVEDVKGLSGYFEPRETSTEVLSGYARALSRGWVLEDRNPFLFHLAVHHLAATFWEGTEEAKDSTRVGLLVGLLATGSESLLRRLLEWNLSQRGEGVVTEDVKQERKETVTKLTGARGTQRVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZI7</accession>
    <name>A0A1E3JZI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034408.1">
        <property type="nucleotide sequence ID" value="XM_019173703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZI7"/>
    <dbReference type="GeneID" id="30190753"/>
    <dbReference type="OrthoDB" id="2585251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="486" mass="52424" checksum="362934866AA70D14" modified="2017-01-18" version="1">MPPLFTSTSLTTLLRSVAGAAKRIQPQAMSRAPQRTITHISKARNAVHKLAHQTFPSLATPSHQLYQPTTIRAGARFASTQGPSVAKSARPFGAVGRGLQAGKRPQWGHGRSIPSNVGLGTARGFASGPASGIHAKVPMGLRAFAGLLDDDCKVNKTLPRASRYSPYTRKAGHHTRKTCKSIDSSFIADLHHYFPLITVSVEESQLPLPPTPETLTTAGKTTVLSLPLSPSLEALLHPTSELTYSETSVGVHILARLTTGILPIHSAFSIHSSTRIIPLLNKLESLGVLDFHPGSPFVRAEVLRDADGQPDILRLVFEDRSVGNVRELLGESLRKHEEGEWWALWEERKEVVELSQGERREMMEQWSEQSEEREVDELVMPTLDVSALETPSSPSSDGISTPFSGDLSVTSSLFSHLGDSEDWSIPLSSVEGSEVESAYAGSDSWGSVNISVVGGESESSESSEEGGVSVWWAGAGEGFGFVAQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZT9</accession>
    <name>A0A1E3JZT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 35 (UDP-sugar transporter), member A1/2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034498.1">
        <property type="nucleotide sequence ID" value="XM_019173793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZT9"/>
    <dbReference type="GeneID" id="30190843"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="705" mass="74726" checksum="4D219BA1F3813859" modified="2017-01-18" version="1">MSMSRASTRSPSGLNRRPTMDRSASHTGTSPAASSPLQSTFGGRINGSPEEDRLTMRDREKDRPDEKGSTRGKAGGVGVGVTRPKRRLSSLPNLKPKLNRAMSATSVHSPPQSPLGEPTHNPYRTLQQQSFHNNAQSHGSSTGSSTANNYKTTYNRQNPPRMDEKVGMVGYATAMAAASREKEGPPKLWGVELKWISLITLALQNALLTIIMHYSRITASPNRTYSAAAAVLANELLKGTISLFIALTRIDKDLTTSPPPALYGEKGGDDDNRLSKLPTIFHASRLRTLSTAIFSPDCYKLSVPAILYVIQNNLQYVAASNLDVATFQVTYQMKILTTAFFSVLLLRKRLTRAKWASLILLAVGVGIVQIQSTSAPAAVHTSHAGHEHGLRSEIPPDHNMATERVMHPMRGFIAVTLACLTSGLAGVYFEFILKGSSSSNSPPPDLWIRNTQLSLFSLIPALVPIVVNPSGPDGAGYITKVLGCFDNFNGWAIGTVLTQTLGGLITALVIRYSDNIMKGFATSLSIIISFMASVALFSYPITLTFVLGASTVLFATYSYNAPTPANAIAPRTSIAVAPGSPITTSAPILGEPEKPSRASSVINLLGLGGASNAGSRKPSMTDVRGYAGTGGSQLGLSSYPQSGSVSASAPGTPAMSSQSGYSGRSSPAAVPNTNMHGGPGTGFQRGTVGDKVRPILSLDIDRKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZZ5</accession>
    <name>A0A1E3JZZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034475.1">
        <property type="nucleotide sequence ID" value="XM_019173770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZZ5"/>
    <dbReference type="GeneID" id="30190820"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="106"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="286" mass="31598" checksum="1DF101D3230820C7" modified="2017-01-18" version="1">MNPFRTTLLQASTSFRSSVRRAAAPVVTRPAAQLPWKRCFADSPKPPRSGLDTEQQKARDQSTVGPFTLKAAGFFIVTGVGLYMYFESEKTKVQQRRLEELASRSVGRPNIGGPFQLTTQDGVPFTEQDLKGKWSLIYFGFTHCPDICPEELDKMGEAVDMVDKATGKGEVLPVFITVDPARDTLPQVKKYIKDADFHPRMVGLVGDYEQVKKTCKVYRVYFSTPPDATAADDYLVDHSIFFYLMDPLGQFVDAFGKATTADQVASKVLDSMKKWEAAGGNAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZZ7</accession>
    <name>A0A1E3JZZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum-Golgi intermediate compartment protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034558.1">
        <property type="nucleotide sequence ID" value="XM_019173853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZZ7"/>
    <dbReference type="GeneID" id="30190903"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="47986" checksum="3F36842DC2DE6D22" modified="2017-01-18" version="1">MYEPHLVNPTNHYGTHENEGMSLLDELDKIAPIQSFDAFPKVEETYTIKSRRGGVLTAVMGFLIFLLVLNDLGEYLYGNPDYAFAVDDDLQKDLQLNVDMTVAMPCHYLTIDLRDAVGDRLHLSNSFVKDGTNFNIGKAHSIKNAASPLSPSASEVISSSRRHTPNQKSFFSGISRFFSSSPDRKTASAYRPTYDKVADGPACRVYGSVEVKKVTANLHITTLGHGYMSFEHTDHNLMNLSHIVHEFSFGPFFPAISQPLDKTYEIADQPFTIFQYFLRVVPSTYIDSSRRKLVTSQYAVTDYSRSFEHGRGVPGLFFKYDLEPMSIIIRERTTTLYQFLIRLMGVVGGVWTVAAFGLRVFNRAQREVARKIVGEKEFIRSATTHTPSPALVHRESSGYFGGAPGMMSRATSWVKGGSPGGADLGGNWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0A9</accession>
    <name>A0A1E3K0A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034561.1">
        <property type="nucleotide sequence ID" value="XM_019173856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0A9"/>
    <dbReference type="GeneID" id="30190906"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="325"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="448"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="73290" checksum="325DC831DE89BF9A" modified="2017-01-18" version="1">MDQPILFDTFLLLLLRLLYFLLSRKFLTYTINPTLRDISQPETILPATASIPQDGDRPRRAAPLGIDSDYMDTDDNTPISSYPSSPAPFTATLASSSRESRRDDYPSSSSSLPNLPNQTGDNIELHLIGQKLKDASSGVSKKVLQLSHGRSHDKGTKSLKKTTKGLHRMSRILFSVCFAESCTLISLVLFHSLGLLHSKSRQVNFSVSLHVILAIVLVVIPLVQCLLLTYRTKESSTASTSPSRSTSISFTTHLIISLIPFSLYIFLFTRIPPYITAVPLVLSQSEPSLDVDDPSATAATLDEAIVQWSTSGPEGWEQGGWLAPSLGRVVVLGIVVLGGLSGFGAVRTAWNFFEHHRAGGKSLTDNDLLQAERSLYRVRQDLISKKEEVERYAPVSGSSGGWMGRMFGGENGQVASLQAELGGLAAMESQVARSLKAMKVRKRRQDFGHTYRGQVYNLVGYVFAVYCAARLLMCLPSLFYAPRTAEQDSGEIPTEGKGNTNGDWISFFLALAISKLPKGFADIDVPTWSRGISLVLTGILILSSLAQILRSLSKILRLTSKTVGAGFLVLSLGQLFSTYVISLLIQLRTSLPPTLPEADPLMYPNGTQIDPFPAAPADTRGDSLLATLPDFRVFGRLFDILFLLAAVSTALYRYIVLKVASADDSGDIYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0G2</accession>
    <name>A0A1E3K0G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034603.1">
        <property type="nucleotide sequence ID" value="XM_019173898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0G2"/>
    <dbReference type="GeneID" id="30190949"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16736" checksum="B35C50D14F98A625" modified="2017-01-18" version="1">MSTPAASLPRSEHEPLATERNPISDATLTIRVIKSFEFRTQKSLVLQHLDLRTLTVGALMEQVREQAKTAPGFKAYRALVLDTLKLYTVAHGHKTTNLIINLDHEDWILSDLEKTLADIGAQNETELSFFNREAYEKFKADPEIKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0Y3</accession>
    <name>A0A1E3K0Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034247.1">
        <property type="nucleotide sequence ID" value="XM_019173542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0Y3"/>
    <dbReference type="GeneID" id="30190592"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="47138" checksum="1AE55BD1852D3E4A" modified="2017-01-18" version="1">MSMNHPKPRQIRLPFDVPKPTKSVPQARICGICRKGDSRYTCPRCNVAYCSLDCFKSEAHDQCSEPFYKTTVLDSISADPKVGLEEKKQMMDMLRRFEEKEAEGGNGLEEVGSEAEDEDEELIKLFEGVDIESMGSNDIFKLLPPKHREAFIQALQNPDSEDTKALLEAASQDLLPQAPDVLPWWETEASWAERNREDESDGPRVAEEPETIPESVLEGINPPDRVGKKLAYNAIALRRVKYMAYLHTLLSYRLPSLHPTHLKSQDVEASELKAYFGLLTPFLVEPKSTTRHESLGSAWGSVWEAISSDTDVPPLAETLRHLLGLIPDLLHPPITTPAYPRVLLILSDLYGLFTIPPGKIGGAVPRKVAFYVKALRQMDRTEWLHLESEIQKEVEKLERESGEGEVKEERRERLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2E0</accession>
    <name>A0A1E3K2E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034787.1">
        <property type="nucleotide sequence ID" value="XM_019173061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2E0"/>
    <dbReference type="GeneID" id="30190102"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="10">
        <location>
            <begin position="273"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="677"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="754"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="967" mass="105588" checksum="D6D1ECB52AA0B9EA" modified="2017-01-18" version="1">MSAQNNAVASPADAFADYLPQLTTALDSLTTDAAALPGKSDLDFQRTMDRSFGKDLDKASQRVLNLTERVLALVDESQRAAAAGEKKGKPVTRRRKLEDEDDVIDGYKGSVLGVVDGLLEDADTQMDELRGSKGKTNIAIKPSILAQAGKKLPGPFSKQVERLPQNIIHAVGLSKPQLLFPDAPDNTRTDIPWAPTLSNKPHAMVPLGAKVKLDYELTAEEEEDSAKAAARLEREQKARHHPYYYETKHLPYPTSMFIPSQPIPPRPFDSTPFMFVDTPEKYQQMVEKLKAAKEIAVDLEHHDMRSYVGFTCLIQISTRDEDFVVDTLSLRKQIRDDKFGDVMTDPSIIKVFHGSDSDVIWLERDFDIYLVNLFDTYHASFTLNMPQRSLAGLLQLYCNFEADKRYQRADWRIRPLPEDMLHYARSDTHYLLFVYDNLRNALIEKSSRPPSPVAGEESVTLASARPNPQEAIRKVLERSADTALRLYERDTYDVEAGKGTGGWLSAGKKWLPKGGLDEEVGWVWRRMHDWRDGMARELDESPFYIMPQNMLAQVCTQGNPTNLGRIIRPDRAPIAAQYIPNIASIITYAKKEFKAVEEERRRQEKEEMFADGGIVIPEQKADKAHKQQAQAKKRIAVPAVPAVPSAPATAGNMWSFGQQSTPSKPVVKTQAKSGLFGSTIKSTPNFTPSSNSSLNKTKPTSGLFGKTLPRAPAAQAQPASGSSTSAREQKELSPGFLKVMDAMRVEMAPKQILKRGEEEAGSGTLRPESVPFVPAGQRKTAPASGAVSSSAKPAPAPAPQKATPSAAGPASKLSAPAPGDGVVQVKKSKKQPQKKREASVGVDSDGSKKTKLNNGDGASTSTTATPDASPSGTPAVAPKSEKAKGKKKEKVKPENIPDFDYSTQPNLLDQPQSASSGADAKKKKKKNVKQAPKPGAFTGVEVPTFGARPARDMSQPKGGNKAGTFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2H0</accession>
    <name>A0A1E3K2H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034686.1">
        <property type="nucleotide sequence ID" value="XM_019172960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2H0"/>
    <dbReference type="GeneID" id="30190001"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="800"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="832" mass="94316" checksum="28C0DEF0BB60330E" modified="2017-01-18" version="1">MIDPQLFIPGVQTPFTRPASPSSLSSGSLSPGLPAPTPRIEQSKDEIEHMLIKMQILAFTEHGIGNELESLYASFSRCLELRDKYLELSNQRLGDNPRDHDGTFHGFNPPSAADVTGLKPEYNPESSELPPNAEDALPAWNIYPPPPAPHWHWKKADNGPLPEPAPLTNQGEEENDGKKAKGVSSKDSEVFEVADCEIPGRDPTGWTYGLNDEGVFTVFAAEPASAEATPVKEGEAPQRKTPLSRVPTLKEYFTDLDYLLGVCSDGPAKSFAFRRLKYLQSKWSLYCLLNEYQELADMKAVPHRQRRDFYNVRKVDTHIHHSASMNQKHLLRFIKSKLRKSPDEIVIHRDGKELTLKEVFQSLDLTAYDLSIDMLDMHAHQEFHRFDRFNDRYNPTGSSRLREIFLKTDNLLKGKYLAELTQELITDLEQSKYQQSEWRLSIYGRNTNEWDKLAKWVVNHKLISHNVRWLIQVPRLYEVYKGQGLVNNFEDVVKNIFGPLFEVTQDPSSHPELHIFLQRVVGFDSVDDESKPERRLYRKFPTAKMWDTKQSPPYSYWIYYMYANMASLNAWRRSRNFNTFVLRPHCGEAGDPDHLSSAFLTAHSISHGILLRKVPALQYLFYLKQIGLAMSPLSNNALFLTYERNPFKDFFRTGLNVSLSTDDPLQFHFTASHLLEEYSCAAQIYKLTPADMCELARNSVLQSGWEMQVKKHWIGQHWYLPGAAGNDIHKTNVPTIRLAYRQATLLEELALIRHGKHSPSATPTHLKPRTETTAAIPERPGMTTQASDVGAAAMSMSAGVGTAGVGATNGSHLVGGASELDQRSLEKQRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2H9</accession>
    <name>A0A1E3K2H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034696.1">
        <property type="nucleotide sequence ID" value="XM_019172970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2H9"/>
    <dbReference type="GeneID" id="30190011"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="757" mass="83879" checksum="D3F93A6FD8E7412D" modified="2017-01-18" version="1">MPAGFAYDFLLLFWRIIINIFFREIRPRGAFNIPQEGPVLFICGPHANQFLDPLLLFSEVRKESGRRVSILTAAKSMNRKFIGAVARVFDSIPVARAADYATAGKGRIVLSESDPLIVTGLNTDFTTQVKPHSQLVLPKSAGYAAATVGEVISDTEIRLRTEFVVPSKDGNANVKASTRVRTEGEQKEGLEYKVLPHVEQEDTYGACFQRLNEGGCIGVFPEGGSHDRTDFLPLKAGFSIMALGAKALHPDLDVKLVPVGLSYFHPHKFRSRAVVEFGPPISVDPELVELYKQGGAKKREACGKLLEQVHDGLRAVTLRAPDWETMQVIQAARRLYRIPGQHLTLGQVVELSKRMMEGYLVYKDEPKIIDLRQKVLAYNRLLRDMGIADHQVERASNKSVKSLLLLIYRTGLLIWWSLLALPGTILHAPVFILAKLISIQKAKEALAASTVKIQGRDVLATWKILVSLAVTPLLYIFYSILATYLAYKYDLAPAYRHWTPVVIFCWLPGWAMASLKFGEAGMDVAKSLRPLFLSVWPGNQREADKLREMRESLTEEISEVIDEFGPELYDNFQRGRILPSASVPQTGRNPGLLSRKSQSADSSVLSHPMLWLDERIFGWNRSASIGQSVWSSGRMEKTRSEMEAEPLSPTDSDGEEYEADVDYDDVLAIIDTKRSTGDDAASPSERRRRYTGGSRSEGSAASPRSDTSGMPLPKVDDEGVLRLHKRPGVAAKGDVDEDQGEQGLGLDTGKGKAGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2M8</accession>
    <name>A0A1E3K2M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034562.1">
        <property type="nucleotide sequence ID" value="XM_019173857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2M8"/>
    <dbReference type="GeneID" id="30190907"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="642" mass="70467" checksum="6BE09CB02D1C879E" modified="2017-01-18" version="1">MTTEPSSTTYGARASSSLSSISSDERGSQKPAKVAGKKHAREASPEDKPSEGTKAKKPRASTASSKSKAPAKPKAASKSTSKGVKPANGIAKPSANKANGILDGDSDLSGLESDSTPTEKSVAKPKPVKGLKASASKQKAPAKGTQAGGKVETKKAAAGKDKKVPPATKKKVEPKPKAERKPKVEPTPPIFEKIATRLSFDDGEQRMALRELLWRFRYVLSIPDRSLPALDDFDRPITEANVRLFSGALLDMIKDEYDAKKSDDNEDILEDLFNFREELRYYADLVRFAAIFNLLSEPLNLRLPVAPIDRRAQNDEAGLRNLFDLDENSPAPAWTTGFAAPSRRGASKVPEPAEVVKMLLSLAERALTTPKMRGNIENFTVETKARREHGNTTKKEVNAWEERKKKLSEERIKCKTAGETKANTTRTNKEFQQHKLRIAQANVNLRSELHLACLRFESLGTDLDGRIYYALSHRPVTDDTRPPVGWGTGLIVWGSAIEGRVSEEDNLPSSVRRWTHFGRAKEVKELHTWLKWKFDRKTEEIKKGKGKGSSINSKLEASSLAAVPASPTRGNQATAEDDASSASSGLTPPPVSSTEEMFALVHPDDYEPSQEALQEWSKDLLGKVADVGEWLEVLEWKGLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Z2</accession>
    <name>A0A1E3K2Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034981.1">
        <property type="nucleotide sequence ID" value="XM_019173255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Z2"/>
    <dbReference type="GeneID" id="30190296"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26337" checksum="8C7542A6876E13BB" modified="2017-01-18" version="1">MTSNNQDKVILITGTSQGIGEGIAKHYLKQGWTVVAAIRSPEKGLNLEGNVITVKADQSSLTDFQNVIEELKTRHNITHFDIVVANSGTAGSGALLTKASPTEFDYVYQVNTRGPLVLYQATRPLLKDNGTFVVISSLAGSLQRTFFWEHIGLYGASKAAVNYLARTIHYEEPTLKAFTIHPGVVNTKMARESWDDFGKPPFEPETVDDVVPGIVTLIDTSTKEETSGWMWNNDGSKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K326</accession>
    <name>A0A1E3K326_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034922.1">
        <property type="nucleotide sequence ID" value="XM_019173196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K326"/>
    <dbReference type="GeneID" id="30190237"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="25654" checksum="0F4214664D46FDCE" modified="2017-01-18" version="1">MSCADDLTTEDLNGNVTAEVLERTSAGEGSTTNLWSHIDRDNVTGLNLDDPLSAPKLIKPWDNRLDEEQIVESGVDDELIIHIPFTSSVRLRTLVLKPPAADHPHRPTRTRLYANQIHCPDFSDLESMTPIMDIDTSQPAAGVRRLPDGRRDVEEWPLKVQKLANVHSVTLLFSEAATSLRSSMYFVGFKGVAPKHEMDMSKLGRVQNENAADKPVDGVAERQGASNTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3W2</accession>
    <name>A0A1E3K3W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034704.1">
        <property type="nucleotide sequence ID" value="XM_019172978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190019"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="800"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1598" mass="172707" checksum="3DAB72CDED2D0CB7" modified="2017-01-18" version="1">MAAIPGWATDELGEEWPESSPSPPPTAKHHPVPSLKTNPDSISAKRGSLRMLGQAAARPLPPSRSASSASASEPKRIVSGHVDEGRGHVSGTGLDVGVLSPPSSRASSDGKPEPVAGTFVVKEGVDDDRGAHLARNGMGVKGKDIFGALPLERMFDPPSPAAADVKAEHAQTAEPSTSPESAPPTPAPKATEPPRRASHQYAPLNPSRLSKSVTPSSNDSFTTTTSSAPSRSTTPIPAPPREHEGEDSLLRDSTIIRSDIDDSAFGGDFVTAPQGEESRNEIQYAGSQGISIQSYASSTRVREDSPFSAPGASYQFTFESPHQPSQSAQFSLEGSPFDPERDAAVDGPSHSTLNFRSRPLPSVIAGLAAGPSSGQTPINPALRLFRSTYDTFTREHLSAMVDSIAIEPSPSPPSIPSVRGLREWSPAADDSASPSQPSSASRAGSTPSTMSSDARSSKRLRLSPASPPARRAPLRDWAAQGAAMIGKLRGVDASTDGGSVSGFSGNEAQEGNTVDYVSSPSPPVQAPPPAKSNSDRGTQSDRPTHRSNPSSTSSGYLQAAADIMARIKQRKVSESASDSPHIHGALTESDDNRVWEEEAGRYAMAKGKGKVGPSPRRILRHLSASEEVKRAREEETDSDDEGEQIQFSQVSRVSYASHTSSVNRQPPRYLEERRPTSQASSVDDAGGPHIPQPPQFNADDLNRYMSSSTHATTTTALSTSFVKHRGPRAAPPTPSAMRMIRPDEVRDVVPDRIGKMRYDRVGMRWVRELGAVDEAGESRLTGSEESVDVFAGMESLAAEERSRSVVPQQAAPVDLQPLDESIIEHDRELRENADDEQSLVGRPERSAVTSSSSSEDDQVLQHHDDITNLVQDEEEDDSGSESDVDEQTVRPQAAPLQTSPQRPLHHVHSAPAMMTPTPSAFAPRPLRSALRNVNGGSATPAPGPKKRQGWSDEATPMPAGRGATPASSQRRSVSFSDGKKAGKIENVEVEIQMARWTAKAQDEEEDLFRGDGTSGEKSFLPSARTKRIQGLLENMGDLTLADETPSKPPSRYVEKSDRPSSRNSLANSSRQSHSLANSSDSDSAVPIRSFRNRSSGGPRNTADATFLTECSFGVAHDKLVEMITDAEPFNPHWEKLKSINLKGKGADSVARLKEFLPNLDEANLDDNAIGYLSGIPSSVRTLHVAGNRLTSLTSVNHLRNLQYLDISGNKLDSAAQLSCLIHLRELKADNNGISDLSGILDMDCLIKVSCANNKLEGLDLSSSRWSKLESLNVSNNSITFIKDLHQLSSAASINLDGNQLDVLAPSKPMPNVRVLRFSDNEVSHFDVSLFPKIRTLYADNNSLTHIARTDRHASSRLENISLRNQRAPSLRLTFADLENVRRLYVSGNPLGDDFFPRRPLYSLVYLEAAACKITAWPSNFASNMPHLKMLNLNYNYLTSLDGIKGLKELRKLTIVGGRIGGEEDSKANKDIISGLRGVETIEELDLRMNPSTLSYYFPLLLSSSSPSSILDPSTAKPRLADQSTVAKPVAAPPALWHSYDNRFRKNLPDEWYSKRLLHRGLVMKACPQIKKLDGIVVEDGEKKKAEELLRAALVARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K504</accession>
    <name>A0A1E3K504_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035054.1">
        <property type="nucleotide sequence ID" value="XM_019173328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K504"/>
    <dbReference type="GeneID" id="30190370"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="212"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="372" mass="41735" checksum="4212748266EC362B" modified="2017-01-18" version="1">MWHGKVQGLAVGYIVEPVVLSHASSSYQVIGAEDCTTVFNIPNAVISVTNRHYRLPPTSTKPTSQMSRLPKAKLEKEDILTFALKPSELTWKWGYPDSKDISLFGDTAGSTPSGEGERQRCDRCKSIYTVSSDLAGKERECRHHYAKAKPVLGRGKIWRHECCDRQQYTEGCSYGYHVFRHNDDDKALAKREGYKSVKEYAEDGEKDKDWVDVVALDCEMIYTLAGLSLARVTIINTAEKVLLDEFVKPTQKVIDYNTNFSGITKSNLDGATLDLEGACAAVCKFIGPETIIVGHGLENDLRALRLFHDQFVDTSALFPHPRGLPRRRGLRQVVKEKLGYSIQDLQDKLGHNSVVDATAAVDLVRWNMLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K580</accession>
    <name>A0A1E3K580_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035215.1">
        <property type="nucleotide sequence ID" value="XM_019172273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K580"/>
    <dbReference type="GeneID" id="30189298"/>
    <dbReference type="OrthoDB" id="2574687at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130758" evidence="1">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="31915" checksum="D472E8E1CD911451" modified="2017-01-18" version="1">MAPTLFTVTFFSLALTSLAEAYNVLHTVENATGTFYYDYGYESTGDRCSGRGSGAGTLSAVPHCENNGPSYSDLGTNRIVAMNRSMVNGDLSAWCGKEVKVFLSNGSEVEYKEPLVLWDVCEAAETAPIIDFSVDFYLNLMENGDCMSNNGNNPAGLKIQIVDNQIWAPAPGSDSYSPTAASTLYSGGGYNGINPKNTEIPAWGDGKGVDKAGQIPLTVATAAATTIKTTSAGAVSNEQVASSGAAQSSTSVLGAVQTSTTLDGTCTKGQQKCENNQLFICNYISNSAGGLSEFWRWIWKGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5M1</accession>
    <name>A0A1E3K5M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035172.1">
        <property type="nucleotide sequence ID" value="XM_019172230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5M1"/>
    <dbReference type="GeneID" id="30189254"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="201" mass="20626" checksum="F46328F0A195410F" modified="2017-01-18" version="1">MGKYYCDYCDIYLTHDSMNARKAHNTGRNHIANVRDYFAGLGHNQAQSLIDQIIQQHESGGGRGMGGMGGMGGMGMRLGAGFMNPVGGPPGGFPPPQAFPSFPPPGQTGTPPFRPPFPPTGTPNSLPPFPPPGAGMTPPQYGTPNAGAGAYGAPPAFVAQQGQQQGQGQVQGAQGGFTPAEGVPQGSGTGIHPDRMRMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5U1</accession>
    <name>A0A1E3K5U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035400.1">
        <property type="nucleotide sequence ID" value="XM_019172458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5U1"/>
    <dbReference type="GeneID" id="30189488"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="163" mass="17706" checksum="D0EBC034038E3EC1" modified="2017-01-18" version="1">MREKLPPSLQASPEESKEESAVQSSKVKTKSEKLWDIQLRKIRSSATRLGPGGEVPQDEKRYFEWAVDVEGKGVESWEKGGKWMGKASRGWVHRDTPLGKVMDLVITQSRTPRPFSAAEGLALAQLYTPPGGKPTVTPLTLSHPASGLVEGSLIVLVSGSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Z6</accession>
    <name>A0A1E3K5Z6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035366.1">
        <property type="nucleotide sequence ID" value="XM_019172424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Z6"/>
    <dbReference type="GeneID" id="30189454"/>
    <dbReference type="OrthoDB" id="2574384at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130799" evidence="2">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="310" mass="33814" checksum="2F22213BD89AE660" modified="2017-01-18" version="1">MPSTELPWVLANPILIHTLSVAAVGAASCDSLRILSLVKPSPSQVHYESTTPDAPVHLVISPVDNTNDVHHGLPIAGSIGIVALVAYGYTAHLPLVGAVLTWTYSSNIRMNRLKMGSTILSMLGALAVSCIVVGGVFAVLWGLGTWNDEPNKKPPLEDPVLSDWVTNLNAFYLCLITLTHPGLIITMTYRFEYSQLANQLTLAEDDQDKEDSFSGVTSVAPVCIPVDYPSFPCPITITSLLFLFLCLAAMDLTLGKNIEYVSPFPALVVIFVVPFFTAVAAAQQGKFGEWWRYQETWVPPKQDDEDEPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K641</accession>
    <name>A0A1E3K641_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035263.1">
        <property type="nucleotide sequence ID" value="XM_019172321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K641"/>
    <dbReference type="GeneID" id="30189350"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="241"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="575" mass="62173" checksum="6711D173D4847EF7" modified="2017-01-18" version="1">MSLHPQYSSDDHDPFLSRNPSATSSLPTVEDASNQPQYAPEQQHYAPPPLPPRPSAALTRKPVPAISDSDLPALRRRRSSATPPPVPPRPNNQYSTYVAAPAAAYTVQPQGPVDSRLPPASSGAAYVATNEKAGYEPKRRSCWPATRRGKWILFGIIAALIVIIAVVAAVCAVVIPNHSSSSSSSSSSNVGSASDNGGHPLSIADGGVDKGEAGDIPVHGNRSADHFVMTTNRSIVVTRLDPIVNPGAIGSHMHRVHGSSYFTQNLTTATEMQELANCTTTIVQDDLSAYWVSALYYRYSNGSLVSVPLDRTSLYYFQKAPTGETIYPFPDNYNIVAGNPYRRSVNESDPNHTALWYQCYRGDGNDLKSWGFPKSACSGGLVQGIQFPSCWDGVYADDGDYTDHVTYPTDDTNGYYCPSDFPKKFITLQFETVFAVYDFPYNGNNNITWLLANGDTTGYGIHADFMNGWKTSVLQGVLDDFADDPPNCPHLNASINLDITYSCRLQTSIVNEEVGETVSTALTYLPGCNAIWSGNTSKPACPDGRVEGGDLDLVSGSVYYREEPYISGGSEALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K699</accession>
    <name>A0A1E3K699_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035563.1">
        <property type="nucleotide sequence ID" value="XM_019172621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K699"/>
    <dbReference type="GeneID" id="30189654"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="318" mass="35144" checksum="D14AEBDC3E773979" modified="2017-01-18" version="1">MPRSRSPSRSRSRSLTRSRSPLSRSPSMDRKESLSPEIKDEDLSPFLIRVFVTKGRHTPLGDFDKATLPLRDEFQVYGSKQTSPSDLIRSLYPSFPPIYRSPQTRFHFKHIYVDASPRGLYRSKDLTSFIGRDLSYADPKQIRADEDTMIDDDEDEGLHKKGGRKIQEKTLDGYGFITGDFISVSLSVPEPRFPGGHGPAAVAIAGINGAAGPGGRGGDAPREGGWNDRRAPQGQGKDESEKGADAPRWGRGGPLPPQGRDAIAGRGARGEGREREPLPEGRWGRGGQGRDSGRDAGRERDRSRSPSRGGERWQRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6D3</accession>
    <name>A0A1E3K6D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositolphosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035280.1">
        <property type="nucleotide sequence ID" value="XM_019172338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6D3"/>
    <dbReference type="GeneID" id="30189368"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="193"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48533" checksum="0CB2E301F8F3173C" modified="2017-01-18" version="1">MSSFGRTLAPLTTEARPSFSPLAVLKPFLLAIQASLLRLDLSRDPRKTLNRLKQHKFTLGNTLPLAFMVACALHSLYIMEPFLLKFAIPLVYGTAILLPITSQFVWPATPIFAWLITFFCARFIPSGRRPTIHVALLPALESVLYGANISDLQTRYTNAVLDVIAWLPYGVLHFTIPFVVALVLWSVGPRGAVQYFGLAFGWMNLLGVVCQILFPAAAPWYEIIHGLTPADYSMAGSPGGLMRIDRVFHSSGYTNAFGSAPLVFGAFPSLHAGTATMEALFLSHFFPRFKPFFWAYVGVLWWATMYLSHHYLIDLVGGACLSVLVFYLCMPEGFKDVDQIQWDKVEGEGYEMIGGPRTGTGPDIDLDEEIRKLEEEGEAIFESIAPGDEESRIGEEFVAGGSEGKAPKPKVKKQRSVSWGETKVLGEGGVQQEEGSRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K714</accession>
    <name>A0A1E3K714_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035184.1">
        <property type="nucleotide sequence ID" value="XM_019172242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K714"/>
    <dbReference type="GeneID" id="30189266"/>
    <dbReference type="OrthoDB" id="10469993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="243" mass="27153" checksum="15C5506FAD2E5EBB" modified="2017-01-18" version="1">MPSPSSSSPSTDESFPTVYAPAPVFSPSPVYSSSPTSHPLTSPFPLISLSRDLYKQHVHRLYRSVALHKGNAELFYREIFDPEPFAAISIAPDEELWKRLAGMVNGGREPDTRLGPHDFRPGKSLLNKLCLFWEDNHLTTVDVDAIDDTDEAADLLLDLADHIFSAITKTTTEQPAPPVQLHLFHHAVSVCYRWESIESMCESPDDRMFPKTYSSAWAGRPLVCVNPPSTPMLGRILHRSSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7A0</accession>
    <name>A0A1E3K7A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035796.1">
        <property type="nucleotide sequence ID" value="XM_019172854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7A0"/>
    <dbReference type="GeneID" id="30189893"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="687"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="901" mass="100467" checksum="2F6C9B8D99E4FC8F" modified="2017-01-18" version="1">MSSSPSPSSDDDTESIHATQFVPQEDDSDTLYDAIRILDERVNKRGGGEYLVEWAGIDPDTGKTYLPEWTAKTACTNDLIKEWRAVKRRDPDIVGKGAARWDDRIQEYQKWKKELDRKKAKAEREARLKVNAKKRKRSSTVTVKTEKKSRTSKGETPRSKTHSITLKPAGSTTRRRSTRTASEPSETSARTRATRPRESHAERQPVVEQSSSDSEEEPENDELDSDEEDDDAVRQSSAKNKGRAKVEVVPPTKQSANGTKTKPKKRVLPISKDVTDYPEPSQVPTEFAQPSQPNIEEETDPQPTQYPISSPIRPEVSSLNMNPHLPSSADTINQFISPPFMRHEKKEEAARRHLREYEEAEALAKAVASLPGKTASGRTKGKGKERQDEGEEAGVEGAPKEIVVYDLTESWPESQIPQTQPLPASSPKKSTQDETPLSDQDLRKENDKLRMQLKDALEARASMIDTLKYHPDSVALEKVKAENERLKEELAAAQADAEEVRGKGKEEGAEIRLLEGLKREMEGLRKELSAAKIGKDQSDERYNNHPDSSALVHARAEVAELRKLLEAAQQATKEAKKIAKDHPIALKLASAEEQIQTLTAKLQEAKASKNSLQSEIASLTEQLEAAEASRASEAEHQRFVTKEYEKARDRAVELVRKSDVLTKQNQLFRGQLRDGLKQRELFNHATSSAHNAQIKQLRAQVKILLDQARVTGDPIREKAVWCDKYREDSERLTAENEDLDRKLRKAKGRQVELLEENQVLRARAMGVLPPESEGDSDEDEDAARGYMTAEDVPARRPFPPGPSGLGNNHPASPHSDFFLSAPEAQNNFAHPPGTISGAATGLGNVVREEGQVEELVEGGRGYECKWRDREEACKVVCDTAEDMFAHGKQHPVAEMAARGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJT0</accession>
    <name>A0A1E3HJT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027962.1">
        <property type="nucleotide sequence ID" value="XM_019180061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJT0"/>
    <dbReference type="GeneID" id="30197300"/>
    <dbReference type="OrthoDB" id="10310297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="712" mass="80127" checksum="775FB8EE56DD261F" modified="2017-01-18" version="1">MSKLSKFSQEEKQRGLNTMVDYASSAIQNRARALIDVQRRKRHIDETTDALSQLASIKSADGTPVADPETDYKVLTLDDAESLLLMAGIRKPGEGRGDERIPHYHNWDANTASQWSKRIHQLSDNLEARRSMYVMGNDQSGNTIKGAISAFADVLHEVSVVNDHEHDFKFKEALGFGRARHMADGLRSHLVMETTLPKIANQIHSYLSQAHSANPETLPSARSKKQKLWDQSLSEAESSIAYMGSTGWQVDPDDKAQLEQAVERSHTLLPKKSEKAVQKIEAAFLLDDYSGYYDNTTFNETRIGDLEEHLEHKLAEVAHQKFVLDDGWKKITGFPVDYVQIEQEMNEEAEAEAVQGSQQSVATLSGYGIPQDILFQPRALEFTEQKLQRLQDTFEYSSDISAYRPSAAQSHVKNIITLKSDAVSQLDAFLKAKADQVDSKDVPRSQLLDLYESKKRSLTGDRESRLKSARMTTALSRYTDIERKWENLTKSAADRILQKVADARDRLEQISQETQDIQDQSRYCRAQSDFATINALINESFQPAFDSKASKKSWLNEIQKDRTHAKSSLEKSWRLPRAASEPSLATVKEGVQTLMIDESLEIIEPSLSLGKEAEQETATARPWKSRFNWADEVEGDADTTFDEELKEWLAAEAQRNGRETAAVASTPASELHEAEPATSNVSAPVVTTNRWMRSDGKSAAQYLYEMSRASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HS41</accession>
    <name>A0A1E3HS41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028137.1">
        <property type="nucleotide sequence ID" value="XM_019179901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HS41"/>
    <dbReference type="GeneID" id="30197131"/>
    <dbReference type="OrthoDB" id="2577792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="737" mass="80865" checksum="670AAF20E180DB23" modified="2017-01-18" version="1">MFLSDKDQPGPPENYGSFFDIDTALRGQEETDAVSALFSNRKILQNMIAFFDLAGKNEHTEAVTVRAHIALLERLLEWNYIVNGDKIGEGFSELHTAGGSLSLYDARVREDDGWDRSYRQTTHFSRFVNWSRKNAKLLDEGAEGKVGAQAGIIKPDGGISASVVCKFDGIDMPTLVNSSEPVMEPNESLTSFSRVSAGLRTQYKLDNNQVLYHIVCIVMEIKPPIIPEMHLIGQISCYAGGLHDVCGTSYGYAGHGPKVYRLLVLDNAIVFEGPSDGVEVFKNFNLLAEGLEDGSVEVGRSLLLKDTDKKGKKGLDKDLVKDIRKLFVAAIKQLKEIRCDHQPLKRLPSPEGPTWTALRDRVKTATIENAVTQPEPLFDAACLSKKKVAKRKDKGNPASAEDAESGPRAEDSGFVAPPPEGAESTEVIADAQPGTNVNPKKPKRNKKKKTKPQSVNNPPPKNRCNRSRSPGGGGQGPTKRRSTINQATPAGPSATTSSATKEGGQRGRGAKTTDRTVGHRVGNVRESNGNTTDVLKGQDSFESASSQEEIQAPHASIVINPEMTDTYGNDDVATTEYDPLTAFNLQNIDSYMPESNASEKVRLLHESMLMDPVMNGGQTHHNALPELRNIEEEVPKQTANGIMEDDIIDEEDNGSLDRAPSAVYDDPLEEYWLGDDEKRRAFNEKIKLVAARSVLRQANTIFAIASKEIFNRCLDEAIKFVHLYVHAIGLRLTQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUJ3</accession>
    <name>A0A1E3HUJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028118.1">
        <property type="nucleotide sequence ID" value="XM_019179882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUJ3"/>
    <dbReference type="GeneID" id="30197112"/>
    <dbReference type="OrthoDB" id="10302433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="23927" checksum="760CF41A10403FFD" modified="2017-01-18" version="1">MSQSNNQDANNPLNRCREFVDVYIRTIQNRRNASEGHSAESRGASSVPPSVDPNDIEENVIDNWVEAENANTPSTAIPEDEDSVGDDESTPPTYDIGPASNSATHPTMLGFMFTTEQTGIAGKSAVILCTNTSPQGASYARWMQDQVNSGGRDRLWNRISIDDAITLYAGDLDQDRRDAVSGWISIGLDEFWRTGQSTFNLVHRGASVEEDAAQSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV40</accession>
    <name>A0A1E3HV40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028199.1">
        <property type="nucleotide sequence ID" value="XM_019179832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV40"/>
    <dbReference type="GeneID" id="30197062"/>
    <dbReference type="OrthoDB" id="2560567at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="640" mass="73619" checksum="516CFDA10F9CA0D7" modified="2017-01-18" version="1">MGAPTTPPPPSPTPWQLSMYRLSPGERLLYYLYLPILSTTLILLSLLASLPYMFCKRSRPLLPKRSPPDPKHPESRYEWYGPEKDYPPGLALAPLGKGPGLKRRMWEMYGFFREFLFMTTRQGLQVGGVLSGAVILFFQVEMMSHDYTSDNVKKYQDAISGGDGEPSGYLKSDDKCAYIVGTGIANWGDRQEPLAWYGCYHGFLCLLCICLMGDELFNVRFGAFAPQWFRGGIGYTIMFLVSATLSTSPNWGINDFVQLRYLFLTVIFLFGLYQVLRTLLSSIGITTSGYRHTDYRIGRKPLRPWTQSEWLDPYYRQNFIPYQFDRYFWTESVQSKVGDWHFPAERRPREDVEEQMEWLERNSKGRDKWLVDMKVQKVYQKTPQEIKWQHGKIGRTIIHGGPKKMPPFMLDDLHARERAHLGQIPSSPPPTQEEQEEIIKTWNEDKFYFGIANWKPKTKSFGWWWFDVRRAFAVVCAVGLMGVRIGLCIFDLGSTNMPAYRQEYEQAQDAWDSTDSGGPDSSTCQYYQGSSLPIFVVMSEESYYGVTANMIWLAIWHLHLLGMCTAIILVSISNNMWWGMHWPFPPITLIGPRMTSMSIGVTLGFVAFATLQQGFFFGNECVFLVQSFFDVSEKLTWGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HWW3</accession>
    <name>A0A1E3HWW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028156.1">
        <property type="nucleotide sequence ID" value="XM_019179852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HWW3"/>
    <dbReference type="GeneID" id="30197082"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000067">
        <property type="entry name" value="Endopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129409" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="46228" checksum="8D0F7F61DD2C1335" modified="2017-01-18" version="1">MLPLLALLPFLALTTALPAPSANVAPGPTGTAVTSKLPLKLLASRQYSDSLVERQAWLKHQAKSLQAKYALSLDEEWKKLIGMSKRDSGSVQLEDLNYDGTYAGTVSIGTPAQDLLLVLDTGSSDLWAAGSGCSADFCEDVETFNKNASTSYQTADGTFRITYGSGSAAGDYGTDVVDLAGFSLANTTFAVVDQATSGLIDEPLSGIMGFGWTALASSNASPWWETLASTGQWDDPEFGVYMARFRGVDNATNDEQEGGEITFGGVDSSKYSGDLNYISIDDSAKDYWRIAVEGLSVNGDDISLSSPQAAIDTGTTLIGVPSSTISSIYAQIPNSEPLDSSVVGSAGYYQFPCNATASVTFTFGGQEYEMDGEDMNLGSFTDDESMCTGAFFEQQMSSRSPIQWIVGAAFLKNVYAAFRYEPAAIGFASLVANGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HX26</accession>
    <name>A0A1E3HX26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S small subunit ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028230.1">
        <property type="nucleotide sequence ID" value="XM_019179808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HX26"/>
    <dbReference type="GeneID" id="30197037"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN80326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="192" mass="20553" checksum="70013B1E3163F89B" modified="2017-01-18" version="1">MSLSRSLLRSARPIASSSRQALRSFSSSRPSYAEPDAEAAAPVSPKIAPIVETISTLSLLEVSELVSALKTRLNITEIAMPAASAPAAPSAAAEAPVEEKPKEKTIFTVKLEKFDAAAKAKIIREVKAMMPNMNLVEVSVFMLFGCLVEGLGGFCEGREKYVDEVGEMWGVEGGYDRWTKKPCRQGDVACGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1J8</accession>
    <name>A0A1E3I1J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028321.1">
        <property type="nucleotide sequence ID" value="XM_019179704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1J8"/>
    <dbReference type="GeneID" id="30196927"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25864" checksum="499825BCBABD23ED" modified="2017-01-18" version="1">MSTNSVHVSFQRREVIAGLRDLVLLVGLVAWWLGMSELKKYRPIGLILLPYVLMRWKWCATPYGTRVFGAVFATDAPPPTARQAQSLAATVLPTFAVWCLLLCCEVLAIVNVVLVLCLFRDLPVVSELLSELFEGIPCPNPNPDLEANDPSLAPPAIDAPPPNAGPAQVPPEVQAQLDRMEALLTSQAEASTVLPSLALWCCLMCCERLANVNLGLVLFLLKDLPVVSDLVSQVIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I2A7</accession>
    <name>A0A1E3I2A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028312.1">
        <property type="nucleotide sequence ID" value="XM_019179695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I2A7"/>
    <dbReference type="GeneID" id="30196918"/>
    <dbReference type="OrthoDB" id="10465120at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="118" mass="10651" checksum="3230B19B08CB5820" modified="2017-01-18" version="1">MFFFRIFNNNFSSKGKTNSSQATYAMPTGQKAPRVDEDEQLLRLRGGCFGGHFDGNRGTGGTTGAGAGVVMSGGGATSACGGTAGGGGGGGCGGGGGGSGGGGGGGGGCGGGGGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5A7</accession>
    <name>A0A1E3I5A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028361.1">
        <property type="nucleotide sequence ID" value="XM_019179673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5A7"/>
    <dbReference type="GeneID" id="30196896"/>
    <dbReference type="OrthoDB" id="10284825at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="241" mass="26702" checksum="C858B5E33186D667" modified="2017-01-18" version="1">MQLVLPDSICSRSDWGVGEDTNVFERLPITMIEFVISPGHPQVQFEVDRDPDNDSVNVRITDVGEDIDFLETEVTCFHPVEGLTQPGLDSETGLLYHAGDFYVSKENMTLGSKLFADKTRLDQIDHEKLEGHASVYDNGVAVGPWPKFLRNISLTRTTRTGDDVSLDLKALYIPSQKNVTRPAATDNYSHVTIRLDDTDVCSDARFLVPAKLSDYTPMEADVAGRTGPSFTEASMWSGITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5Y5</accession>
    <name>A0A1E3I5Y5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028392.1">
        <property type="nucleotide sequence ID" value="XM_019179624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5Y5"/>
    <dbReference type="GeneID" id="30196845"/>
    <dbReference type="OrthoDB" id="10424642at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN83937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="100" mass="11150" checksum="1E827B610C312010" modified="2017-01-18" version="1">MPDHIAATEPHSFMAHSNAETSASSYATHRNNFDKSMRQLDTLNFTRGEGPDQRKLLQLLERQVRLVGAKQYMNAKFGAGTLQYVAGLYTMMAASIAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9K0</accession>
    <name>A0A1E3I9K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028426.1">
        <property type="nucleotide sequence ID" value="XM_019179569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9K0"/>
    <dbReference type="GeneID" id="30196788"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000010">
        <property type="entry name" value="Tryptophan-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="640" mass="71083" checksum="D9B8A001C1FE9C74" modified="2017-01-18" version="1">MLPAPRLLKAFTRTLPRLIPKNSAHTPPMQTPDRTSKSGTMTPGAIASELSKLDLPAPTQLHLNTKNLPPPKNDPFSPQSADTIDTGDISGPEPEAIVQARHKARSESMSEQLSEKFSNMKFPQPERIFGPNEGGSQSAQEHNGGREGVSAEDWDKIKLADEVPEAVKEPTRMTHSRHGSRVEPPTPKEPTTIKETPEPSAAGAKEQKITPFDVEAGVDAEGKLLAIDYDKITKRFGANIIQQDLLERFERLTGQKPHPLMRRGTFYSHRDFNLILDRYEKGQPFYLYTGRGPSSDSMHMGHLVPFMFTAYLQRVFNVPLVIQVTDDEKYLLERDAKKQADLMKKNKIKKPIDLLRHYKKMGQENIRDIIACGVIPEKTFIFSDLNNVSGTFYENVVLISKTITLSQSKNVFGFADSDNVGMYHFAAVQATPSFCNSFPQIFGTRDDIPALIPCAIDQDPYFLLTRDSADRLGYKKPALLHSKFLPALQGAGTKMSASKDHTAIFMTDDAKKIAKKIKSHAFSGGGASKEIHERDGGNPDVDIAYQYLTYFEEDDAKMERLANEYRAGTLSTSQMKEACIEKLQEVVAEFQKNRALVTDEVLQYFQDPTRKIDPRPKARDAAATDSAAPAATSVPGAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9L2</accession>
    <name>A0A1E3I9L2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028436.1">
        <property type="nucleotide sequence ID" value="XM_019179579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9L2"/>
    <dbReference type="GeneID" id="30196799"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN85264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13511" checksum="2A6BBB6B2408D331" modified="2017-01-18" version="1">MSAGQTYYEFYRNSSIGTALTDALDELITQGDIPPQLAMRVLQQFDKSVTDSLQQKVKAKTTIKGHLSTYRLCDDVWTFVVKEPQFKMEGIGAGSEMVTGPKIKIVACKSGDAAENTKKGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9T4</accession>
    <name>A0A1E3I9T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028474.1">
        <property type="nucleotide sequence ID" value="XM_019179528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9T4"/>
    <dbReference type="GeneID" id="30196745"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27050" checksum="BC2C1E242411433F" modified="2017-01-18" version="1">MSSRTESVSNTLASAIANLEKDQELRKVGRTAGHPLSRRWAGHDWKSLEPIEDLARSAWSTVNKIHSAPSAQHAAICEKSLEITRDIKPLWASVASLIPEGEFHRYSYAIGPINRSLTQTIVFSRFMLFDELTPAFTVSDLIGLEQDTTKNLILSAEDYLQGVISAVNELPRLSINAVTSQNFDLPVKISAFVNDIFSSYSLLNLRNDALRRRFDSLKYDLKRCEDVVYDLTLRGLAPAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB85</accession>
    <name>A0A1E3IB85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metacaspase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028585.1">
        <property type="nucleotide sequence ID" value="XM_019179444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB85"/>
    <dbReference type="GeneID" id="30196656"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="59963" checksum="72899B341C2A07C5" modified="2017-01-18" version="1">MSDYGDDYEEPQERGFDDDYEDRRSERSRSRSNSSSSSSSSSSESHHSSHHSSQEEDRRYEDQQAYQQQPTNSGSGGAGLGGLGGGAAMGMMTGMMGKLMSGQGGGGNRDGGNGGQGQQYGSQYPQGGYGQQQAYGQQQYPQQQYGQDQYDQQQYGGGGYDQGGYGGGGGYQQQGYGGQGGYGGDSRGDGGYGGQGFPYPGAPPQQYEPTNAGYAPPQAPYGAPQHQFGGQFTDPRSGETAQAFFEYSRCSGRRKALLARTPISSDIGINYIGTSSELSGCINDAHNIQKFITERYGYKLEDIVMLTDDTNDPRTIPNRENIIKGMKWLVDGAQRDDALFLHYSGHGTQAEDTDGDEQDGDDEAICPLDYETEGLIIDDESDHELCVRPLPAGCRLTAIFDSCHSATVMDLPYVYDTEGNIKEPDLLQEASEGLLGAGMDILRGDTDGIMKSLFGAAKSAFSAEKADEKTKKTKTSPADVVMWSGCKDDQTSADTQEAGKATGAMSYAFIASLNKNPNQSYQELLISVREEMKGRYTQKPQLSACHPIDTDLQFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBT5</accession>
    <name>A0A1E3IBT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028616.1">
        <property type="nucleotide sequence ID" value="XM_019179368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBT5"/>
    <dbReference type="GeneID" id="30196577"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="90"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="286"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="817" mass="91209" checksum="3F9053D98407B016" modified="2017-01-18" version="1">MAGENKASTSKVPVKGKGGKGRQPQPKIKSNQLKRNKANDELKELKSRVDSFEPPSEITQFTELPLSDKTQKGLKSSHFLTPTPIQSLSIPSALQGKDILGSAKTGSGKTLAFLIPMLERLYLEKWGPMDGLGAVVISPTRELAVQTFNQLRDIGKYHNFSAGLVIGGKPLKEEQERLGRMNILIATPGRLLQHLDSTVGFDAAGVKVLILDEADRLLDLGFLPALRAIVGHFTASTLPNSRPSRQTMLFSATQSSDLAALAKLSLYQPMYISCNKPGEEGAVPANLEQFYAVVNLERKLDALWGFVKSHLKMKGIVFATSGKQVRFIFETFRRLHPGLPLMHLHGKQKQPTRLDIFHRYSSQKTALLICTDVAARGLDFPGVDWVIQLDCPEDVDTYIHRVGRTARYQSSGTALTFLCPSEEEGMKARWEEKLLDVKKIKIKESKMGGLKQSMQNFAFKEPEIKYLGQRAFISYMKSIHLQKDKTIFQIDKLPADAYAESMGLPGAPQIKLGPQKKAEKVMGGDKKGEVEEEEEEGGEESDAEVRGVVGSDEESEDEEEGEEDEESESEVEADKPKSQAIRTKYDRMFERKNQDILTPHYTALISTEDDDNDDVFTLARKDHQLSGDEGDDVDTEALKAELKKPLISSEDLSKRKLKAATSRKALLKDRPAPEKVIFDEETGEARDFYKSGKEVEQEESNEERRKAFLEKEREIMRIQDKIDKEVARGKKQELKRKRKDREKELRAIEAGESLAYIGGGSEDGSDAEGGSYGSPSRSPSPERRTKKQKMSAKRDEDSDEGDMEDEEALALRLLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBX5</accession>
    <name>A0A1E3IBX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028646.1">
        <property type="nucleotide sequence ID" value="XM_019179398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBX5"/>
    <dbReference type="GeneID" id="30196607"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16305" checksum="04AC50657509D2B4" modified="2017-01-18" version="1">MSVHEPSSDLEQRLEEEEVAPPPAPGATERFRVPEEATRIVTNYMDSSTYKEHKSRDPTYTAIGPAVQGGLVSGKRSDTKSHVQMVQGDRWTKVEGTLFGAGWSVGEGTLLEGNLMIDPGVAMELSDLESLEDVRKEAAWYMPPPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICI8</accession>
    <name>A0A1E3ICI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028671.1">
        <property type="nucleotide sequence ID" value="XM_019179315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICI8"/>
    <dbReference type="GeneID" id="30196522"/>
    <dbReference type="OrthoDB" id="2570493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="673" mass="74694" checksum="5E98F21B34B7C600" modified="2017-01-18" version="1">MSFVKHLFVRTDDPPCDLEKNAVPYSELSQTYSDPFSKSPVGTATQRPSVRTPPLPPLSQHREHPSPPRFQRPRAQPPSPASPMTRLPEFSRFPQFSPTKQQTYSSPDRLKMYTSLPYCHSYTISRRERDGSHHPVTTIHTKPQSGLSSASPAVSGAGMPPDLTPISNKHDPLLPLAIECIQSLCADADRPRNALTPSPIPTHAAASRTPSAQFLQVPQVTITDNTRDSTATAKTFYAFQEFGWLLEYIGAEGTERERFPAMTRESKASFVESCAREKVNMAVRSARATLLAQGAADGGVGGEKGKIIDKLEELQAFFSEDGSREGSDGKATVEEEDTTLRGGESGKFDTSLDRSLNFSRPLRVDIPASTRSSQTSIFPSRAPKDGYTDIVAPRLTQDFNTGGLDLSDVVKVKRFSFEHVEHPLEDHDESEGAVNDSFASDTSEIAATLGTERQRRTRPPVPINSIRLSRWPSQVDPKYLSRPADWTPVKMQVAPAPFAPQEKDVERAGESWLKGAKVKTREEEMARWMFVLGFICPVFWIIGGWWVYPSSDKVERRQRPKSNTRSQARSTPHTSVDFETGTPFIPITPNRSSYPFHESVSSPTALLGQQSTDLRGNMVGQKTQLSETGMGKKESWWTHEEPMVRYCRHAAIVAIPGMVFAAVMLVVSFVFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICY4</accession>
    <name>A0A1E3ICY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028682.1">
        <property type="nucleotide sequence ID" value="XM_019179326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICY4"/>
    <dbReference type="GeneID" id="30196534"/>
    <dbReference type="OrthoDB" id="10299500at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="39597" checksum="A7F65A93926637A8" modified="2017-01-18" version="1">MLAPAQLLPSPAPLSITHSTPPLVPPRPVLERLHPVRYIILDHLFRLRPIAVLQLSKSHYQKYIPQLYSRVTITKHRVERWAASAYHTPEYSPFSARDALRAHTKTLRLCSSRGLQYLSALLLSHGEIFSSVGCLQISPKLFPRGANADSILYSIRTIINCPHINITNIALLLDPENHNSAKTYIACTCIAEIVNAGNLPIDTLTIHIPKIPIWKQSIMRDYVIDIGYLGLVWGSRNRLRLVFDLNARAYPTGGNVISFTSGIRYLTTALVPMLALPRYRHFKIEFLINDQGRPAGGGAPGGGWLVPEATWRTMQEKGPDTTRYPAVKMFWEGNVRVERVSGKETRDALELPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID87</accession>
    <name>A0A1E3ID87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028747.1">
        <property type="nucleotide sequence ID" value="XM_019179266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID87"/>
    <dbReference type="GeneID" id="30196469"/>
    <dbReference type="OrthoDB" id="2583791at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000104">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129689" evidence="1">
        <location>
            <begin position="26"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="378" mass="41347" checksum="8C5CB5020D1BEE23" modified="2017-01-18" version="1">MFLNTLPCCSYILLAALAGVTTTTARPHSLFTDNPTVLSRSNSAVQQIHIATVNVKNSNIAKQTASDYIWGEKSWDDRKTRLADALLSTGPLDIWGAQEVLSAQLSDLAWLFGSDYGHVGVGRDDGKEAGEFSPIFYNSTKFDVVRWNTTWLSTTPDVPGSVGWDASLTRIATLLTLRYRDGDQEGKLVHAFNTHYDDQGVEARANSSLLLRATIKQWVDDVEQDENAGGDAPVVFFGDFNSPPEEDGYQNMVSLSPLPSGNASFTFLDTYTHLLTSTSNSSLSSTYGPLQTRPYGPAHTYTGFEAPGYNMTKRIDFILLGAELEEAQQGGGWGARGGWEVSRFGVVENYVEGDVDGFNARWSDHRAVRATIAKQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDW6</accession>
    <name>A0A1E3IDW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028814.1">
        <property type="nucleotide sequence ID" value="XM_019179197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDW6"/>
    <dbReference type="GeneID" id="30196396"/>
    <dbReference type="OrthoDB" id="2568950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129695" evidence="2">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="147" mass="16219" checksum="BE5CD0CD443F9F08" modified="2017-01-18" version="1">MFKSIFTLTALALLGTSLPVSAQSDPSNTTDTYDHSNHTLGGETGTTRESRLADIPVYARNYTRVSQKPENDDIESYINQFVSTCPEYHVKNLTTEVNSGFGERGDWDGNNEDTQALIYCLRTDDNDNVVDSFIEEIVSQLGGTIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE16</accession>
    <name>A0A1E3IE16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028832.1">
        <property type="nucleotide sequence ID" value="XM_019179215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE16"/>
    <dbReference type="GeneID" id="30196414"/>
    <dbReference type="OrthoDB" id="10579242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="209" mass="22682" checksum="2FD2129BACAF49B6" modified="2017-01-18" version="1">MPQEASPLLKGTSESTMTVKAVVMSPKAYTSRPLMAKAAPNNNSSETGSTSKGNATVDLNRAPSKITVSPDSALDRSSPLPLSSYTTSSASGDTPSAHVVQFTESEDILEPGILHFTFEIVVAVTGGYLGARRTLSQAGRAILSWSANRGLEEQWERWKVDMSFWVWMAAADTGGLPYEIVAKWLDEDPVAKEYQYDNLLDVVEHIQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE49</accession>
    <name>A0A1E3IE49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_07202</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028831.1">
        <property type="nucleotide sequence ID" value="XM_019179214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE49"/>
    <dbReference type="GeneID" id="30196413"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="207"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="357"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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            <position position="155"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
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        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN86839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="638" mass="70499" checksum="1BD8D92B9B5FD9DB" modified="2017-01-18" version="1">MAAQYKALGVTPPISTEAPKPTDLKSSETLLADLVALNQFESDQERKVRERLLSNIAQLVAKFVHDVSIKLGMSEKIATEAGGRIYTSGSYRLGVHGPGSDIDTICVCPRHIYREHFFGEFQDMLRAWPAVTEISAVESAFVPVMKTVISGVEVDLLFARVNLPEAGDGLDIEKDEILRGVDDASQRSLNGPRVTDMMLNLVPDVATFRTALRTIRLWAKRRGIYSNVLGFPGGVAWALLTVRICQLYPTAAPATIVGKFFPIYYQWNWPQPVLLKKIDNGPPNMQHSVWNPKLDRRDQAHRMPVITPAYPSMCSTHNITASTMSIIRKEMLRAMQITDEILKNPGTTWQPLFEKSDFFSMYKTYVQVVASASTSEGIKDWSGMVESRIRTLVQDLEQTDTILTAHPQVGGTNRIFYCLTEEEQAAASQGELTTEMINRTEEDVKDKEHRKIYTKSFFIGLEIEKKSKDGTSRVLNLFYPSKKFCATCQNWEKYNEMEMSVILRPAKRSVLPSYVFPDGMPKSKKSKRAQQNSAGDTGMNDGSDGQGPAKRTRSENVIPENQTPQPLPNGVPQSNGADPVPSQNGAGPVDLKPPPGIENMPPLSTAAMSSFATAAKGVAGAQDENKDGLIVLNQTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEN7</accession>
    <name>A0A1E3IEN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMKK/CAMKK-META protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028858.1">
        <property type="nucleotide sequence ID" value="XM_019179100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEN7"/>
    <dbReference type="GeneID" id="30196297"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001104">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.234, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
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            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
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            <end position="105"/>
        </location>
    </feature>
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            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="635" mass="69722" checksum="135908FA94323F76" modified="2017-01-18" version="1">MGAPSLQPPATVVSPPSPTAHRLPHSPRPRPRPPTTDSPERLEAPVDPSPAPPVSQSPPSLDLHHPSPSIESPAPSPSLLRPASPIFASHGVLRSPSPSSPSFRPRVAHHRRASSTHRVRETIDGTQTASKDGERMINQYRIGTCIGQGAYAKVELATDINTGIEYAIKEFSKSRLHHQSVQEKHRTTARSRRPLRGPRRGLQRGPVPDDNDEPSVFEMHKEEAPAESASDPLGLIRREVAVMKKIDHPNLVHLYEAISVPTADALFLVLEYMPGGTLMKIQIGQDDATTHPPFDVWQTREYFRQLCLGLEYLHANDVVHRDIKPDNVLLSADRQFVKLCDFGVSEMFTRHGDDRIGKSGGSPAFQSPENYTASPDLHGRAVDIWALGATLYCMLTGTLPFNYPNVIELYAAVMERDPRIPDDWEDSLQDLVRRLLCKDPEQRIVMDDIRNHPWTTDGGTEPMISTDENLYDVGKHVEAPTEEEVSHAIGTFRGVLLRRLHLTRTTSQSISSPSNSTDPSLASGSMDSYASRDPLTTNTSLSSDPEDGEFGDIAGDQVMSPRQMSLVSPAETEKQTPWKFKLNDLKKLNTDAIDLEGVGAGQEGAGAVMVDSPTSENEDAQTARVGSGSSQMPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFJ1</accession>
    <name>A0A1E3IFJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028944.1">
        <property type="nucleotide sequence ID" value="XM_019179026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFJ1"/>
    <dbReference type="GeneID" id="30196219"/>
    <dbReference type="OrthoDB" id="2576405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="580" mass="64292" checksum="5A08196585A42C85" modified="2017-01-18" version="1">MNGEPNYASRTGPPAPVTYPIATLNPLLAFPQSLSPRSNPHTPASDPLDTGLAADTADSGTATGAWNVLPASELGHPANLDKPYPLTLVPFDIANPPQHEDSLVILPYDEIVFEDELRGYLVEEYKAGRIGEGVEYEDTFVLPYLRGFYLRLQAVKGLKARRGERLQIFPTTFTTSVRLDLDIYMRPKDTVKGTSDGNDVEAKEARKRKGKEEQSASIVTSTAAKSYMPDVGLVGYNLEQIAEKTFRKPPREEPSTKRSSGAQISTGRSERDFILYSINHIKWSPMVQNVRDEAEKRYLDDINLRCARLDALFQTLYHLHNAYRVAGCRLAIAWANEFFTRMVNVTGKCGPQTILVEASPKSMSMSSKRLPNRAADGLNLDDLITLVHDDDWEAPNSLIRDHDDWHYDEEAKYRLDATILMTLATTTHATTLGDVAVSGGSKRGREVDHDEYQESSLPFKRSRDVRQGVDDDSFVGPVDDSAYLPTQSQSESILRPPSRPASSPSVPSSASSPNRTDDTDSVTDEALLELEFPSEDWTHGDYAGALEKTGTKVLLVDPQEMDVLLARAARQGWAEALKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFS6</accession>
    <name>A0A1E3IFS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029007.1">
        <property type="nucleotide sequence ID" value="XM_019179088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFS6"/>
    <dbReference type="GeneID" id="30196285"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="143" mass="14689" checksum="406179FB52206921" modified="2017-01-18" version="1">MASKMDIDKSLDEIIAAKPKPQRQQRQGGASRGRRGGAGGGVAAAAGAGGARARYASTVPKAAGAVPAGVPEVFKIIISNLPGDVTEAAVRDLIQSTVGPVKSVQMAYTAHGKGNGIATVVFKNKGDARKAHASYHNRMIDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIG5</accession>
    <name>A0A1E3IIG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029199.1">
        <property type="nucleotide sequence ID" value="XM_019178716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIG5"/>
    <dbReference type="GeneID" id="30195873"/>
    <dbReference type="OrthoDB" id="2577488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="281" mass="32376" checksum="9B0189EF2B00E44D" modified="2017-01-18" version="1">MQRPDAPLHRLPLPPELALEIFDTYTAITLPGTPEFLTLLTLSRYHYALNIRRLYWDVKLKESMADRFVDMWRRWAFHGVRLVLAAQRRSMGNLDEDEILKNLLCPIKCNSTDFNINTLTFENAICFAKISELFKNPGPDSWYTWDRHPSLPYSLRLLAEAKTVVFEEQTLGGGEVKVGVRYGPSNGYNRYGAERLVIVMPSRPFHCISPLALNWLAELGERLLRDVKHVTLEYKTAVVGEGATLFKKRKHRMEQIDQVESKIKSWDDPSLQITVVEPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIN9</accession>
    <name>A0A1E3IIN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029262.1">
        <property type="nucleotide sequence ID" value="XM_019178779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIN9"/>
    <dbReference type="GeneID" id="30195937"/>
    <dbReference type="OrthoDB" id="2574201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="163"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="35485" checksum="12A361FA5CE5CC7F" modified="2017-01-18" version="1">MFPRATIGLGHTLKRCQHLPTNARLAQSISTTTLSRSFMPSRPLSNSPPISRLLAGPQSSLSISKRLISSSPTSAIRDRYYKRSSGGYYGGGNGGGSNWWSRVKRRLDTIQPMTLVYALIGINGGVYLLWQYALQSAQRFRDPTLLYFLRNNFILNEANVFAGRIWTLVTSAFSHSSGTHILVNCLGLYFVAPAAAGLLGAANFLGLYLGAGAFSSLVSLGYHRMSKHQWWGSEGASGAIYACLAYYGAMFPQSTVLMFFIVPMPVWLAISGMFAWDFYGALFRPNSGTDSAGHIGGIMYGLLGALATRRGGVSRMFQGGSRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIP1</accession>
    <name>A0A1E3IIP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029207.1">
        <property type="nucleotide sequence ID" value="XM_019178724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIP1"/>
    <dbReference type="GeneID" id="30195881"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16528" checksum="3CCB7A84460F433A" modified="2017-01-18" version="1">MVHTGASFTSSATRSTGTSGLKGADAICEDQPSCSAERPTSAHNLPSSIHPDYFLQTGDDFLLVTDDDVGFYVDRDFRLCHSECFHDFEKMVSDIGNKDAVGDCINISVVRRDMSGELSKGYTTEGFRYHQPREKIAPRRLLFITQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJZ3</accession>
    <name>A0A1E3IJZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DCG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029396.1">
        <property type="nucleotide sequence ID" value="XM_019178695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJZ3"/>
    <dbReference type="GeneID" id="30195852"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="23896" checksum="1BC2813A6D1F38D4" modified="2017-01-18" version="1">MSSKLPFAASIGSPTSATRLLYVSPTSNNSANLAKASHLLQLIPSDVRIDFYNAPESAPKSIDGSLDGVVSAAIVLRDLGLDRQDADGDGEGEEKKELGTYGAIIIGCFSAHPLVPALKEALPHPCPAIISLFDVAVYSALQLGPTFGIVTTGKQWEPLFDEAIRAMGVAASRYTGTVGCGHNAVNLQGNLDAMISAGEQLVERGAAVLILGCGMSDRLIGHVYDAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKU0</accession>
    <name>A0A1E3IKU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029497.1">
        <property type="nucleotide sequence ID" value="XM_019178590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKU0"/>
    <dbReference type="GeneID" id="30195747"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="878" mass="94176" checksum="D9AB5463B15F1DA2" modified="2017-01-18" version="1">MGFVDRWDTTQALISTRLSKPVRPFLALHLISSSTIFILSILSIETNASTSHFLRHLIDSADLSSVIFVDKRGNIGDWRIAPARVVNITDVQEDGSSNSLVCNDQGTKCKVVEGKTKKVASKQKAEAESESEDSDSDSGSSSDSDFGSDSGFETEFGNSTSTGTANESQSTSTITTVSTLQGNAITTRLLAVPTVVTSSGQVVTTSILMHEADATLADIESSSLSTGNVPTSTSVASSAVTVRTSSSLTASSTSTTALSTSASLVATSTTSASQVVSSVATSSSSVTSNASSLASASPSAQETTESASSASSAWGESSPSSGDEVQAGRRNALSRHPPPPKFYRRRRVEKKNKSNGEDSSDDEQTDSIPSRRDSAKHRSHKRLFFAGARLEIFNTTGSTASIADFIATTATSSEASAVTTATTSADSDSDSGVDSIVLPKGMTVAQLNKLLEEEPDQFEGIITSPKRLTASVPIKSSLDGVKPVQGEDGTIIGANITGITGVGGGVDTFVSQQCAAGFAWSVNSLDNFVREEIVLACFFMWVLGLAVVAVLNESIPHLMALLFSLVLTIAWSANDLRLSFAFWRKFSEMVQNNCGDDSSFFPDYLAKRGHQRTDARAERLGVLETERQLRTFQRIGASSTMNKMYKLVLGLSIILQLDAFVLVTFFALYLDQITRGQASYFMSNCKAFQALYSILVIMLFPWLYFGWKSIRTESRIQFMVFIGLSVFFLAGWAISFASPTFRTTFTHWSFFKALGILALILTVASLVLAVLRRMTFGRGLSEYLEIGDDVGKWTSLGGGGGGLGEKETEVRVEDVRSEGRKEALPTFSTIFGPGPVPPPRRMFSNTQGVQAIRQWQTESNRASSAPSWAAGDDQRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM15</accession>
    <name>A0A1E3IM15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029309.1">
        <property type="nucleotide sequence ID" value="XM_019178608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM15"/>
    <dbReference type="GeneID" id="30195765"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="7827" checksum="C611B7521855BEDE" modified="2017-01-18" version="1">MAVCSTMLISQANGCSHGSSCTCSSSSGRALSNAAAGDCSTHSGSCACGSNGRLVNECNTNGAGGKCSTCQGTVCACGTGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP64</accession>
    <name>A0A1E3IP64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029625.1">
        <property type="nucleotide sequence ID" value="XM_019178469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP64"/>
    <dbReference type="GeneID" id="30195621"/>
    <dbReference type="OrthoDB" id="2576530at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="65333" checksum="F86517E2501E9E25" modified="2017-01-18" version="1">MPELKEQDVLAYYTAIACGLVHRGSDGKIAPVSFTSTPAESSRQTPVLDTVTSKETSGKGKKGGRKGKKVVEAVEAVEGEGARTDVEAASVEASKSKDKGKGKKKAVDPAPPAVSQTTDEVPPVQPKAKQPKKSKKNKEAATPAVESTNAAPETSTPVLSAYETLAKEISDKAKKRVAESAEAETSRTPEFTAEQPAKPKPRKSKAARTPVGVEDAPAPLPPIPPAPEPSSTPSGPSKTLAKAAKAKTPKSTSRAKPIAPVASPAVESSAPADSSTPARGVPSRDTRALSTPVSEADVYRYHFSHVSGSGSSHDSPASHSLASPGTPASPTQRGKKRKSDALGAETPLRQKVLSRGGMGKKRSSLDAEDLADMEMVDELATPVNSPGPTSEKKKKKSKKSIGGPEVASSAPVESVSVASPIPPPSSPVVPDTSTPSTKPKKSGKESKKDKKEREQREKALALEAAELEEKEKAAAEKKARKEQEKKEKKERRKSKADAPSVSQPPKSPAAAPDPLPVTTPAKDTPITPASKKKRRLTDLPIPRLTPAKSPAVTSSAETGSPSAVKKPRKSVPTTPFGQGQPEPAVMHMYATMGVVTPSPKSKGAGSSKKEKKKLGPRWITETPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQB8</accession>
    <name>A0A1E3IQB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029891.1">
        <property type="nucleotide sequence ID" value="XM_019178172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQB8"/>
    <dbReference type="GeneID" id="30195318"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="133" mass="12897" checksum="DA7BA591F0710CE4" modified="2017-01-18" version="1">MGTKFPAFIATGTALTVLAAGPIVGGGLGLFGFGAAGVTAGSLAASIQAGIGNVAAGSLFAFLQSAGAGGVALPVLTGVVKAVLATALSAVGAKSVLKLTRRHVVAAVRVARVALLREHLIRRRGVFIGGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQC6</accession>
    <name>A0A1E3IQC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029912.1">
        <property type="nucleotide sequence ID" value="XM_019178193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQC6"/>
    <dbReference type="GeneID" id="30195339"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="835"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1217"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN90810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138384" checksum="45BCA44664814D31" modified="2017-01-18" version="1">MVGTSTPTLGYFGSDGISRPILRHRPSSLVHAQPQSRSSSIPSARSIPRRTSSASLTSIDTALSTIAEPARLSQRRDNWQSLQEVAGDEDDEDEEDEDEGGGGPGLGKSHVSIRRLSVLPSVGAKSVRGLFGHQASPSPLRATFGKRDPSLTRSCSSILDGDLTLSPKSTTPRQLEDGPDDGGIFDSGQLSPKSTGKSPFRAQTVEEDLPFSENVPKPAPDPKPSKRLKNTGLWPPSPVTISVFKCAVAYFIASLFTFVPALSRLLSRESMTDIHGRVTWKPADQAHMVATIVVYFNPAKTLGNMFLSTRYCIVLTFITSIASLFCMGTVLLFDHFSPSHGHSWDFVSEMGDWVMCVVWIGGTLGLLAWGKLYVGNPSWNGGCSMAAMLLYNVVIRDGALPKLAETLEIIAIGVCITNLVNYTVFPLSATSRLQSSISKTLSSFSTLLDILTSTFLLEKTIIKEDRTSIKDAIKSHAASFKTLKSDLSEARHESAVDERIRGRKLRLYEAAVASLGRLAQHLGGLRSCTRLQESLIRASKEGKVSWDFDTQTNIDSPIFSISALPPVDGPRKESVREDDVETSVRLFLEFRKSAGAQMISLNDCCDEALETVAALSRSDPTQDNLSAVRTKLADTLRSFRFITSRAIKEVYAGPVEDDDEEKETEKGREQGQRSGSDLSQLADGPNETVFWIYFFLFTYEEFAREIIFLLDTMQELAVSHTPSIWDHIKHVFGRKRGRKEGRGEYIYKQLHNLVPIDPSKLQPPLCPGNSRDSTNSSSNATPKRAPLLERMKRAWWYIGERLAEPDMRYAIRTGLGGAMLALPAYTHMGREYFLEYRGEWALIAYLAAMSQTVGQTNYLSLARIFGTIIGGTCAVIFTKLFPENPIMLPICGFFISMPCFYIVTQLPAYNNAGRFILLTYNLSCLYEYNSRGEVSVELIAFRRSMSVIAGVIWAGIVSRYWWPFTARQDFCLDLSHLYSKLVTTYSKGVDTEGEDSGDHSSDDSDDEGDVGETTPLSAPWSVGHQHLSSSVRQFMAMELHLQSQLDYLRGLLSQTKNEPRLKGPFAYGFYHEVLLSCERVLDRLHSMRCVTTRDEWNDDMRQAFIFPVNKERREMAGNVILYFYTLSAGLRLRTPFPSYLPPAEDARKRLVNAIRGLEVVKRRKLKSGGRHLLFFAYALAMQEVIAELDFLGKMLQDAYGVISHPTVGSFEDLFVSPKGKGQNRRRRGYERGNSRYGSLPHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS45</accession>
    <name>A0A1E3IS45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030056.1">
        <property type="nucleotide sequence ID" value="XM_019178017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS45"/>
    <dbReference type="GeneID" id="30195156"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN91430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="178" mass="19985" checksum="960511C2E5F9708E" modified="2017-01-18" version="1">MSRFAGRKLDAIWFAFCVNQNTQPISILLDCQSLYPPSLIPLPLKEFMLWSAALTRDPILLGAARPEFGWLRCFFWLEAGFQIPCFAIGAWGLYYNDKRVYPLLIAYGASTATTLLPCLQTILFPTPSSIIQPPHTTAEIMSLLSEYVPFLVIPLGMALDMGWRVVKILGEVDGKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITX9</accession>
    <name>A0A1E3ITX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_05739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030201.1">
        <property type="nucleotide sequence ID" value="XM_019177817.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194951"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000948">
        <property type="entry name" value="Related to GCN2-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="220"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="570"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="683"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="700"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="576"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN92067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1666" mass="187264" checksum="96A745C8CE97925A" modified="2017-01-18" version="1">MPEPNKAIQDEELDSLRAIYPDEWHDVPPKKTAWGTEVDGGWWEVKICGLEDERVSVILKGKMTQAYPQQVPPLSLREPEYLTAKHVQQLHTLVQEKAKSKTGEVMIFELIETVRDFITDNHAPLPNPGDVNLLEEKAHREEAQRAAEEANRATEDERKKKELDKNNRYLHDQIQLNTIKKKETADQHKQQLEERRRQESLALLEIGDLETRDLELDESISVAGYEGKWKWWMLFGGKKEILWTTYAAEPDSSKASSSDAVSFVKASSPNVSVQIIDFANPWYSTALGSKRIDSCTVEVLRSQETKSENIVNVLAVKRAKSPKGWERLVLVTEGLSEGVKLRSWIGREGLDEGVTKEYLTQVLHGLSQLHQHNCCQKQLDLDFVLVSSAPHGQKVVKLLGTCYARRIIDMHKSNPFLRSRVETVSEEWISPDERDSPHTYTRPRDMWLVGLLLVQMLFGPDTLNNYHNFHSLVQHAPGLSDSMMDLLTGLLHPNPKKRLTADEALSKLRCFDEITRRAVKMPIHGRTDSIPQSPNELFGASPINRGAFMNHRPSTPHLFAPRLSRYRADFEEVEFLGKGGFGEVVKARNKLDGRSYAIKKVKLRPEDNEQKVYREVNNLSRVNHQHIVRYYGCWLEDLNPPDLTPTVEGGISGLSTGGTSAGQGSTSTEEDIFAVNFDDFSSRRDQSRSASFPRIRFTNENEDDEDSDGDDDESDEDSSTESDDSDGSVSSAATADPSQPQQRRGRGQHSSVQQSKPSLASTSASTNDGTVQRILYIQMEFVEKQTLREAITSGLEEDEVWRLLRQVLSALAHMASLGIVHRDLKPSNILLDGDGNVKIADFGLSTSEMTAIEVASGPATDIADHIDQTSNIGTSLYIAPEVAISRSYNEKADMYSLGIIFFEMCYPFKTAMERVHILTAVRQPSISFPPGWTPNHKANEREIVRRLLVHDPAVRFKATELLRSPLLPAPEKRKEDYDAVILGKCEQLTDPKSTHFTSLLDTLFDPPSHNITEVNHRLVDYTFDNDPDDHLQVWLTVVIQRLVDLFQRHGAVETYLPLLIPETNLLDAFEDLEPVRLIEKSGQVVQLPSSDVLAMGRSATRRQIERIKRYHVGHKYTSHHLGGQPVVAGELSFDIVSPIRSAAAEAELLEVVDKLISEFRGMRGSSSIEYEFHISHETGKFLFLIMGCFAHNVVVLSLILGLVPERADKPRQKLLEQFRHLGASNSANGQSQSRNLLSNIAGLSRTLMDELEQCCIAGDFDVVRKRLETLFASGPAKRRLAGALDDMAKVIDATRACGVPRKILFRPTLAKHSEFFRGGLMFECVRRGKQKEVVAYGGRYDSLLEHFKQPAIHSQTRRVYGVGMSIAVDQIARVVSRYESSLSRRLMEKPNEDERSFGYWSPARCDVYVAAFPQVDMTVRLQVTGELWRAGIRADFQYDDDRSLDEVTQECQDQNILFLIIPRASRSAVKVRSILRRSEEEVPRHDLCNHLRIAIADQRRIDASYASAEGSIPSAQAAALSVEPNQTEVEIKLILPPEPVVSKGSKGRPVRKHRHGTKSVYYDKASDFAAQTQSTLPLLGVDLPPLLLCQMALDMAWIKDDEVWRTLLAKEGIHAGDRRYAEAVREGVQQMRAGTKGNGSGGNDGWMWLFSVRDNKGFLLQGGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU49</accession>
    <name>A0A1E3IU49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_05802</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030264.1">
        <property type="nucleotide sequence ID" value="XM_019177880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195014"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="872"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN92130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1399" mass="152725" checksum="CFD8A6DFEC79AD2C" modified="2017-01-18" version="1">MADTKQRLDRWTTRLGALPSLALPTDYPRPSPAKLVESYQSMPIPATLNTVLMRLTLDFSIIFPASALPTPYHILLTTFAILLFRYTPDPSLVICTSSSDNGNPLLLKLDIAAEMTFFDVLRQVMEREQEAQADVVPIKDLVDHIKPEGPLYRVRFFDSTQVVTDPSTSLSTDLTLFLLASPSDTPTTRTAVPPLELSLTYNSLLFTQSRITATLESLLQLLSSAASHEPAHPIGSLPLRTQEQGSALPDPTADLDWCGFAGAIPDIFAANAKANPDRICVVQSEPAEGQTMMDGPSRGRRMYTYKQIDEASNVLAHSLLKNGLERGEVVMVYAARSVEMVVCVMGILKAGGVFSVVDPAYPPSRQNVYLSVSTPRALLVISSAGKLAPLVSDYINDNLSLRLLVPAIELTPSGIRGSPAGSAVDILAPFQQYSETPAGVVLGPDSPATLSFTSGSTGIPKGVKGRHYSLTHFFPWMGKRFGLDHNSKYTMLSGIAHDPIQRDMFTPLFLGAQLHVPTADDIGTPGRLAEWMADSEVTVTHLTPAMGQLLSAQATRQIPTLLNAFFVGDVLTKRDCTRLQSLAKNVRIINMYGTTETQRAVSYFAIPSVNDDSTFLTTQKDLIPAGQGMIDVQLLVVNRTDRNVPCAVGEMGEIYVRSGGLAEGYLDPNATAEKFVPNWFGQGVERVDTLKDKNPQAAEHWFGIRDRMYRSGDLGRYLPDGRVECTGRADDQIKIRGFRIELGEIDTHLSRHPLVRENVTLVRRDKDEEKVLVSYFVPTDGDLEGLMSASEAAEDDEALDLGSEMIKGVKKYRKLIKDIREYLKKKLPSYSIPAVYFPLRKLPLNPNGKIDKPALPFPDTSLLTPAPAASTADLSPTQKTIHDIWLRLLPSPPPQVALDENFFDMGGHSILATRLIFEIRKTFVVNAPLGLVFDKPTIGGQAAEIDSLRNADLSGAGEEAVEAEKAIDYAADVEILGKELPTFAPLPADFASKEITVFLTGATGFLGAFILRDLLGRRVKKVICLVRAKTPEQGLQRLRDSGEGRGAWDEEWVKQGRVEAVVGDLAEDKFGLDQATWDRVAVDADAVLHNGAIVHWVYPYPKLRAANVISTLTCLQLCAQHHSKQFSFISSTSVLDSEAFVAKADEAVQAVGKGLSESDDLEDGRTGLDTGYGQSKWVAEKIIMEAGKKGLSGWILRPGYVLGHSETAVTNTDDFIWRMVKGCIQLGLIPDINNAITCCPVDHVARLSSLSALSSSASSAFNIMHVTGHPKLRFNDLLGSLQTFGYDVKRVEYVHWRTKLEQHVLETQDNALFPLLHFVLDDLPTSTKSAELDDTNAQELAAASSEPRTAGVTEKELGLYVAWLIRAGFLDKPQKEGKALPVLEGAAMKAIGRTTAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU77</accession>
    <name>A0A1E3IU77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030256.1">
        <property type="nucleotide sequence ID" value="XM_019177872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU77"/>
    <dbReference type="GeneID" id="30195006"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="570" mass="62770" checksum="266B7C4A9415904F" modified="2017-01-18" version="1">MFPPRARRIARRLDALAVKILGPATPAPEEIQLPQPSCAASVTVGHSSMSGSVDRFFLRLSFPRLLYPFLLLWITAWILLIRQQYYIPSSPTIIGCTSAPWDDWPPDTCGINGTHCQDDLTGLAGETFRCMGGCKDTTLGNERWIGGERVDGEPLIIGGGDVDGTYRADSWVCASAIHAKLISPLMGGCVSINPLPYPAGSSNFVSSSSNGLTSTGFNPSFPGAFTLSRVSPFGCLDLHFIMTGFNAACLLIFTLFLRPPPSLLFCVLLVMGYFHILLFSDPSSTPPSWEDVFAGLIPVLLVGYWIWNQAFKFTLRGFTKLPFDLAFWQGAGYWIGIESSTVFARLPISRLGYDSLDPAGIIALTWIIVIAVIVVAIQAWSFRRAGLVRYYLIRYLPLIPILIILANIPNYTLRLHHYLLALAAIPVLSLPNRVSLFWGAFMLGLWLDGVGRWGWDGILQETTSLLGDANSGSYTPVFWDNVTASTTLGWSPITEELEALNVTAYSLLVNDMQIYDNWTDSSISLNGLIDESVDNYFRLAYIRSGSSMDYTDPVMRWANGSWSGMGDVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUJ7</accession>
    <name>A0A1E3IUJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030249.1">
        <property type="nucleotide sequence ID" value="XM_019177865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUJ7"/>
    <dbReference type="GeneID" id="30194999"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN92115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="30335" checksum="DED751A4E4042F62" modified="2017-01-18" version="1">MPPRRAARRSGAEKPVPADIALPAQVISTTLNTDPLPTVTVNTANLQEVKAALDDIVKKYMLDQEFTPSLLHPTVHLSLGYSSVVIALSAALYSFRVSFEDSKAVLWVAVISYAVLQTALWAWKRWVEKGEVFKGKRRRMVKRIETDHVQIITSAPLTPPPAPVVSFSPHTRPSSPSSGPSSPSLSQSPIKLSSPSFSTKASAFTSSTDSKPATGPSYLVHLSLSTTSNKGKSLIHKSRVVVGRGIGELVDESGGVEEGEVLRWLRLILSEAGLVGAEDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVP6</accession>
    <name>A0A1E3IVP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2 J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030294.1">
        <property type="nucleotide sequence ID" value="XM_019177543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVP6"/>
    <dbReference type="GeneID" id="30194673"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="33888" checksum="6FB4FFD1773984F2" modified="2017-01-18" version="1">MATPPRKLNLRSTAVKRIMQEAQELASADVDDDGFTAAPVEDDIFEWHCTMRGVEDSEYEGGLYHFRIVLPPSYPMSAPDIILLTPNGRFELGKKICIDGLTSFHAGSWQPAWGVRTAIVGLRSFWMQTGEALSGVGALDYSKDERRRLAKLSAQWKCPTCEVANEEILPCIAERVDKGKGKAEEEVTEKTEREGAGDDKDVDDKGAPGEPMPLKEVPPSAPAPQALPAPSHISPTPIPRPAPQPSTAIARAPPRAAPALQDPGFVRIQAHQSALDPNRPVPLWLDHLIGFVCIIFGLVVCKRVGTYIMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVU6</accession>
    <name>A0A1E3IVU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030371.1">
        <property type="nucleotide sequence ID" value="XM_019177620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVU6"/>
    <dbReference type="GeneID" id="30194751"/>
    <dbReference type="OrthoDB" id="10490672at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16590" checksum="C0F0BA9B01F5C323" modified="2017-01-18" version="1">MGVLNYTQNKPKDMSRGYLEACNYSKDAQFDFHDRSPRIQALRGPAAALYHAKLKHERQTRWYELQKQKALQKKALEAERVKAGGRAAVPAGEEGKKRGKTDDDSGGRSGGKTDYGDRWKNSGSGGFHFNHSEYDLRDWALERESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW06</accession>
    <name>A0A1E3IW06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030406.1">
        <property type="nucleotide sequence ID" value="XM_019177655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194787"/>
    <dbReference type="OrthoDB" id="2575338at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="932"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1344" mass="144525" checksum="642920E1EC626294" modified="2017-01-18" version="1">MTSQNATLSASVPTAIVEEVSEGRPESDKPTKRQRAVDEGLQASDRAPISIQFGTSSAPAPRPSLRPTAAYFKPTESKGIVFGAALAREAEERSSKASRASTASSSSSKKLRAAASEFVPPSRSFASESANFTFAMPFATTALWSQGGLIDTPSGTSIGDAPACNRLNFVSSSAVPFKPASLRKVSLTSIPSSSAPGRVDSPAESVATTTASEAKIRASAPIFTPGAKSSTNSSPAFAPSRVPSTTPLSTATKIRAAAAVFMPASSIGSGSLPSSPVKGSSRTPSISSTTSKTVLKHDAPAFIPSLEKRKRARAEDYLHKEPAEKTSSEMEVDTAPRENTSASTESGIQTVQAGDDGKVGSQVVIPVPAEDPAPANEGQTTDQEQGHSSSSISAPSSAFDITTTAPSETAEASLREMDGSHNDGGVKRVIEQADGNAEAGILSVEQSVIHFRREASPMSSADRSRPDSLGNSELSEVPSLSEDGRTPRPSLATRHSYNSYRPRDTPDISSSLSEPTVPLDDVVIHPSQPLPSHHTAQIYEKSPSITMLSAYAFDEDDSTEPFATAIEAGTEDGEGVEREMESIATPDVPYTASTLNAHYAESEEEASGSGSGTVREAEFAEGVEQSILFGSQKVGGTPGGSNFEFTFGELSRSSPSSLEQIEEQHRPQDSLQPTLLAPAANAGPARSLRSSAPSTEVSSSALLSAAPSPHVPMVAHDSEEAADFKRSMEYSKMSESPRAAFPDNIPDLLSVEATGRAIGVDSDLNTPATRSYEASGVLKMLEDLRQQYGRKVHISPSPGGIREEILHSVPDLTAQQSEWSSYLIEKLTSALEDQTQLLTTLKQNMSAPPVSPSAYSSTQDEDTKGNTRQEDMFTAILTSQHAILSKFDEVAAIRLSCTDDLHTAIAALHEAEDAAKDRSSSAHVNAESEVRVTTLSTELASTKSQVTSLEAEVGILKQRLKDTRYERNELRDTMDAKEKQLLGAIMSEEKKNEEMDRLVARALAAELERDAFAKKVKEMRLDELEDEKELKQLQLEVDKDEALAELHSTLKESQQALASTQSQLTIALQALHPAPTLNPPEPSPLLVSTSSALAELSQSSYSFHEEIISRISKLDDDMHESMGSRVKEYGEALGENRRLTGEVDTLRQKLESASRERLNLEKDVLPKFSALETEHIHTVVSLQSETARREAAESKLAEMEKRLSVMQEQTMRWQIEVATRHSQAQMGEIRLQTLTQENAYWREFALGADRRRFRSYVASRPFAPDQSVFHTPATEFKSAARSTARIVSSPLTAVTPTRGGDQRNTSPLKRSIKGSTLDSPIVVSDESMDMDIANDESREELLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWP9</accession>
    <name>A0A1E3IWP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWP9"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="22" mass="2543" checksum="AF55160CDA094F61" modified="2017-01-18" version="1" fragment="single">PVIPVLYQHFVYHRDGLTTETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY59</accession>
    <name>A0A1E3IY59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030463.1">
        <property type="nucleotide sequence ID" value="XM_019177712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY59"/>
    <dbReference type="GeneID" id="30194845"/>
    <dbReference type="OrthoDB" id="10618683at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="31971" checksum="2043675D4664641F" modified="2017-01-18" version="1">MSSRMDSRRVSMLATPSWRPFKTCEWTPAVTREDDRSTVTKEEIAWESSRRALTLAYRACNPAPAKKPRKSAPANLENSNGVASDPGDDQDDFEILSGDDHEPATGKKGMGKGKSPKNKAPPKNTASPAKKKPTVTKKATISIRHDTPKELAAFRAQEAGLGILEGLPLGEQAVRISARAVGLSSDRLRLDKQALALKTVALKARLLESRATSSLAVLLSSSRVTAGVPSQVLKGIRDDIANIKACRESILEDVERMALGEEEATGKAARGARAIADMEEEEPEETELSEGEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYT2</accession>
    <name>A0A1E3IYT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030680.1">
        <property type="nucleotide sequence ID" value="XM_019177527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYT2"/>
    <dbReference type="GeneID" id="30194655"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="938"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130469" checksum="9910D1D4482E321E" modified="2017-01-18" version="1">MPSRPTYSAPTSASSNPQAPPMHSAPSLPQPYPMYGGSNTGYYHRQDPYPYPPPPPHHMSGPPPQRIYYNNALPPPPSHYNARDEWHAEHARHRDSPPRQPITVRRDGLEEPSPEGGEQPVKRRRGRPKKVPVPVEMQHVNSGEYPSVMAPPSPGRSSGSDRDPPPPVKQWSGQAMGRGQAPAPQFLQSSHHGDFIHDEPEQIVSINDKQANRPPKRARGSEERSSAMGGDAELEAGMALAGLKRRESAPTSDLKKTSSLVKTEPGEEKPIVKKAEKPSNAKSCAECRRLKAKCDRVFPCSNCRRRGCAVVCPDGDLSCMQGKRLVLASTEQLHERISQLEQALAQTHRSAVGGTIYHPLLAPQFLDGGFASVEQPPITVDYKPPSFSPNSSPNGLAHGSPKNPSSAPSFTLATPLLGPEKRSNRSSRMAVESLLTEDSAVPEGKREDEWAGENAAPAMIIGTVGKPESAEDIEQRHSVFERLKKIITILPPRNVNKQRADHFFETSLWYQTVLQRNEYDTVYEPAVYAPTAANPLSPHKLAVVLMVLTFDTYLDISADENDPKLADYWDGAQRCFDTRFGWAASVAGVQALALATLFVGFGWRGTRASNFYWLRQMTSAALQLGLHRDAHSSFPDEEKEFRRRVFHEIYVIDCLICLNHGQRASIPVEFIETAYPTLSSPLAYKKYDFIRTVKSQVIDIGSLPDSAPASWAKVKEVEEQLMEYDVERLPIVHCPLLRGEQPPDPVEGFTHADAVALQTTTTSMCHYKAMLYLFRPSLRRLIARIRSSPASSITFQQPDIDTVKMTLRACNSIILTSYHLARKHPKLMAKSWMVWVQTFSAAVSMTALGIWCGPYMEQGFLEDVSKKLTEACNMIGENGSPRSQGVLSLLPTLKSLLAGRYPQLLGKDARDARVSPEGEDMLFALLGGHVDAGSSHVQPPPVQSQPQPQPQPQPQPQPQPQPQPQSQTQQPLKKRKSSAQTSSQQQSQPPSSGQLSTEQLHPQQTTPFHDANQMPTQEQLVTQTHMPPQIMGAHSSSPVQVFSQPLNVNGTAEAFASASASAFCQPQPQPQGQMPMSTSWMVPNMPVTDATCGPVILPLAPPNPTAIPYDNFIPTWSSNNLGMDGMVMMDGMGNGGDPFGGPLIDNPPELWERLQALYEPQAPVFWNGGMDGGMTVGDFGGYVPNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J027</accession>
    <name>A0A1E3J027_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030611.1">
        <property type="nucleotide sequence ID" value="XM_019177458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J027"/>
    <dbReference type="GeneID" id="30194584"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN93506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="42652" checksum="24BBE1880971DAE4" modified="2017-01-18" version="1">MPQLRPPGPRVHGLHRQTAGFSEGRRGDKALEDGQTEEEDLDQQVASSGHQHIIERLRFVAPAELTSEAVVVSAITALSYVTFAGGTAPQWKESLAVIRGCLASSLAASSKLGDFSLQADSPNVPWKQYRPLIEFMIRLDIIGSVTENKPSRLLDVYRVLLKPSKTDPTTETQCILPHLVGCDNTTLLVIAECATLSHWRTSAENEGRLQVDELVRRGQDIEDLMDHRDEREACLGEADSKLPEGQADKVRAMREAFFCGARVLWATVVNGPFPGVPKVSLAVQETITALQSLFNLHGSTDINRVLIFPITLAGAHAETPSQQAFFRNMFSDMSETDKAFGNRWAVLQMMEEVWRKRRSMGKGARVEWREMMKNMGWDAGVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J036</accession>
    <name>A0A1E3J036_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030621.1">
        <property type="nucleotide sequence ID" value="XM_019177468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J036"/>
    <dbReference type="GeneID" id="30194594"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="195"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="44359" checksum="2A35EB5D504BA54B" modified="2017-01-18" version="1">MSYQPPSTQGKPFVPDWIPPPVTKTEQDWAQLHTIELSLLDSPDPKVVQDLVELAKVAIKEDGFLYLKNYGVSYDQLMRQFSIAQYIHANISEADKAKLLWDPETGLFEGYKAPYGWKRERARPDGISQFNFYTPEFEDPNKVPECALPFMDEIAAFCEYLTKQVNRRLLTLLSKVLELPDDYLWNNVQSQGGPVAEGYFRHALFRPPPKETRELSGGLRMNGHTDYGTTTQLFSVPISCLQIWGRDEKWHYVKYEPGALVINIGETLEILSGGHFKATRHRVFEPPSDQLEEERLSLVLFNASMGHLRMTPCMESPLLKREGCVSSQGVFKEFQTVMASGISVPTNKQWREAQIASMRDTTVPQKEVEINGKKHSVREFFGVKVLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J087</accession>
    <name>A0A1E3J087_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030790.1">
        <property type="nucleotide sequence ID" value="XM_019177209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J087"/>
    <dbReference type="GeneID" id="30194328"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="55515" checksum="F814A3B19FD5BB48" modified="2017-01-18" version="1">MSSFARLPLRSRMGASPATRLAAVQRHLTTSAPKMASAEELVQFESHQDTRVYKLNRSAKLNSLNEEMITLLSSKLKNWRELDSVKVIIGRGDERAFCAGGDVKQLVLDLEAGKDTAVKFFKGEFQMNWVLGRLGKPYIAIIDGVTMGGGGGLSLPAPIRIATPRTIFAMPETKIGYSPDVGANYYLSQLDGSIGAWLAVTGQEVYGRAAYELGIATHFVTENNIPEIISQITQHTSPSLQSLSALIASFSASSSATTTPSSKSSPDGPSPIKGEVRKFLDKAFKKKSIQEIYQTLDQAEGDASLSAEVKEWAKVQKGHMDARSPTGMAVALQNHQKAKSSKRLDRTLLNDFSMATAFCGKDRATDDFITGVTAVLIERSKTPTAWTPSSISDPSLSPSEINSKFFSSSSPHLKNIEEIGFSPASASSLDSGRDSTWGQFRKFGLPSEAAVKAAVEGYAPGSGAFALTEAELVEQFVDAQGDIKGSRRSEVEQRVRSVVASCCKTGKDGYLEWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0D9</accession>
    <name>A0A1E3J0D9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030803.1">
        <property type="nucleotide sequence ID" value="XM_019177222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0D9"/>
    <dbReference type="GeneID" id="30194341"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="272" mass="29733" checksum="5C69E18810374E06" modified="2017-01-18" version="1">MSSKRVFPLKQPYKNTFPTTLVTSTTHMIDRVPTPVPASYQQRRHSDDDRLHLDSLCFSSCHLSPPHVQSLHFKMTPLPTPTPPSLLKRAKSLEQARPRRHVHSQPQSPPAHSHSLPPSHHHHVSGLHHTSQPLHHTTATTAAAPPSALASATRRHTTTTCDIPPLPHQRQRSSSLISVSSIPSPPLPLTPGLDILPELADESFELFPPAARSAVERASVMADGYPFPHDPYPGGISLGEGATEMEAVDKKRSAAGKRRTTGGWDVEKPKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N4</accession>
    <name>A0A1E3J1N4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH2 dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031021.1">
        <property type="nucleotide sequence ID" value="XM_019176989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N4"/>
    <dbReference type="GeneID" id="30194099"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="42708" checksum="7F65F498BD9004D5" modified="2017-01-18" version="1">MSATQSPQLFTPIQVGDYELKHKIVMAPLTRLRAGAKDAIPSDWAIKYYTQRASEGGLIVSEGTFIAAEHKGYDYVPGIYTPEHIAAWKKITDGVHSKGGRIFCQLWVLGRAADPAVIPVVYSAGSVEDPEPSPFKSDEVKKPLTPLQEEDMDRLVGYYEQAAKNSIEAGFDGVEIHGANGYILDQFLQTNSNDRTDQYGGSVENRTRFPLRVLNAVCAAIGPKRVGIRMSPFSEFQAMRMKEPLDTFVPWAETIAKAQPELAYVHAIEGRGFTVAEDQWYQNDTLAPIREAVAKHGKSIKFISAGGYTPEKALKHAEEFPGDLVCFGRSFISNPDLPNRVLKGYPIRKYERPTFYSQTAEGYIDYEDYAPEQQALAQDEAAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Y7</accession>
    <name>A0A1E3J1Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031121.1">
        <property type="nucleotide sequence ID" value="XM_019177089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Y7"/>
    <dbReference type="GeneID" id="30194203"/>
    <dbReference type="OrthoDB" id="637503at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="189" mass="20603" checksum="7D9F51345D8F94FD" modified="2017-01-18" version="1">MSVSVASLPSTWDACDQWATHLRDVVAPAPPLTGASNYLPWSKKLKIVLSGVRGCLGLLAEPPASHPSATTLPSTSLSVEIWSHLDATLALALVGLLSTDLASLFESIVLDHPSRAARTLWLKLEADYGTRSSYDMWKSVEALTSQPQGSTPVTEFMTPRRQKFEAIKAAGYDFDRWLLESGFQQQGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J342</accession>
    <name>A0A1E3J342_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031249.1">
        <property type="nucleotide sequence ID" value="XM_019176774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J342"/>
    <dbReference type="GeneID" id="30193872"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="281" mass="30199" checksum="1385A601CC588F53" modified="2017-01-18" version="1">MSLRSAPSSPPPFFYPYDPDSPLLVIKGIISTATFGAATGASIGVAQSLNPTVLAMNMTLNMSIAGLGFFALREYIISPLLLSIEATPGHSICLHELQRRLDPLETIGQGEAPTVGQRRTERILDSALAGGLTGGVLSAAFRGRGTFGKAAFTSGLITSTLQLGVNQFRVMRLNYLAGESSPSPAGSTPPSTPPPVSLPPTPTFDTLKSDLPIPQPADKPSLPERMMTSLSTFLPVRKLTNQEYLETLEKKKEGVETRLKEIADEEVRMYEWADRQGKQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4N4</accession>
    <name>A0A1E3J4N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031468.1">
        <property type="nucleotide sequence ID" value="XM_019176540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4N4"/>
    <dbReference type="GeneID" id="30193634"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="434" mass="45894" checksum="429FACDEACCEB821" modified="2017-01-18" version="1">MSRPPAAPAAPPSAPGTPRPATTTPIHTIVQNLPNLFNMYEKGQLSDTQITQLRTLVHTQIRQITANSINSGRPNPLYSLPDAINPSIPYKDVPALVSREGFDAMIKTSTRALVEAKRAREQQNAAAATAAAAAAAVSSNGTPGAPAAVPAAPVSRPGTPGPAATSAPVRPAGQATPAGSSATSTPAPTPPRPRPMPSGLFTHAELTQLARLPADVRNAWLAKEPTRQSQFQASLNYWRAQPKSNFNPANRATPQQNPTNSNAGRPPQNASATTPNASATTSFTGALPDARGFALRPPPGQLSGPGGMNRPQQQLPPPEPEHVRRLRQIHAMLAQIAPGLSVEAGYEKVVEDIIDRMMKEGLEGAARLAKHRNSDKVELRDMARYIDHAWEMTIPGFDAAPAHPVHVAPDKEKKRGKAVAPKASKLGGGRKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5X4</accession>
    <name>A0A1E3J5X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031321.1">
        <property type="nucleotide sequence ID" value="XM_019176846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5X4"/>
    <dbReference type="GeneID" id="30193950"/>
    <dbReference type="OrthoDB" id="10322286at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="184" mass="20642" checksum="6012229315C85ED8" modified="2017-01-18" version="1">MSLMLNSEHYFAYITRAHSWLKAGRTSSLVAIMPESTTTKDEARTELGRQAFSEPHRSTCAECSLLDDQELLNKAQTIAVDMASTLGLQQSQFRTDIQPNLAELEENNDKGWEQVQSFVSDAITNTYRESVILPAELIDLSSMMLDVLQEENNPEGSVPFPVDTLRAFGNRKRPSILTTLGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J662</accession>
    <name>A0A1E3J662_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031599.1">
        <property type="nucleotide sequence ID" value="XM_019176189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J662"/>
    <dbReference type="GeneID" id="30193280"/>
    <dbReference type="OrthoDB" id="10613079at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="124" mass="12888" checksum="194504284874162F" modified="2017-01-18" version="1">MMSTNQSVVDPQASLPASSQPSQPVSSLRLTRPASGPSLVSAPPSVSTGAKWKADEMRASQRASSTRDEEESGSEEEAAEGPVAKRARSSQGGRSGQAGRGGRGGRAERASRESSEWNKCSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6V8</accession>
    <name>A0A1E3J6V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031824.1">
        <property type="nucleotide sequence ID" value="XM_019176414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6V8"/>
    <dbReference type="GeneID" id="30193507"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25545" checksum="0672784382248275" modified="2017-01-18" version="1">MRLILTRHGQTDDNVRGIVQGQTDTPLNDQGRHQSAQLSEALKRDHITKAYTSPLSRASETAKIVLAYHPDAPLYLQDDLRERGRGSLEGQVWIPGTIIPDDAESFDDFTRRSTDWFAKLLDAHIPHLPFPEEAPPLLRDPFPESHHSTEDVILIITHSEWLEQFAAITCSSLYFFGQTEKCDMKARIVNASVAEVNSVYDHQEGVWKGMIEGWGAVGHLSRMGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7A9</accession>
    <name>A0A1E3J7A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">20S proteasome subunit alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031486.1">
        <property type="nucleotide sequence ID" value="XM_019176558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7A9"/>
    <dbReference type="GeneID" id="30193652"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="262" mass="27684" checksum="245D938214A3EE1C" modified="2017-01-18" version="1">MEAISHAGTVLAVLSKEGIALAAEKKVTGKLLDLSLAPGAGVGGEGTEAWMGGGGEKIFLLNNNILAGLAGITSDANSLVNFARNSAQQHLFTYDEDIPVEMLVQRLCDMKQGYTQFGGLRPFGVALLYVGWDPLYGFQLYQSDPSGNYSGWKATCVGANHSSATSLLKQDYKEDLSLEDAKALCLKVMSKTMDSTKLSSEKLEFATMTLDGKTQQPLAKIFRASELDELLQKLELGGTQEDVAAEGTGGGGGSEGNVAMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7F9</accession>
    <name>A0A1E3J7F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031536.1">
        <property type="nucleotide sequence ID" value="XM_019176608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J7F9"/>
    <dbReference type="GeneID" id="30193703"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13489" checksum="631E11E850268039" modified="2017-01-18" version="1">MSDAEHQKHVIAGFKATISNPTTSAEAKEHAQREIEQYEKQHGAHEHHVIAGYKATITNPNTSAEAKAHAQEQIAAYERGGALEGHHFGDTEHVNRVAGGYKAALHNPTVSAEGKAHALAELEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Q8</accession>
    <name>A0A1E3J8Q8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031851.1">
        <property type="nucleotide sequence ID" value="XM_019175938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Q8"/>
    <dbReference type="GeneID" id="30193025"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25803" checksum="14B6E9A13D6C7B7B" modified="2017-01-18" version="1">MSRTAPATEKRIHLTRHAQAEHNVANDYQIADAPLTKLGQDQSRELNEITKNGVQKTADLLLRRPLETMLLGYPGLKFRLEKDGKPVIILDLLQEVGHWPCDTPTHPLSALKASNDGIFSSLDFSRLSPEYASKQGIFDPRNAIERARQVRVWLRERPEKEIVVVAHGDILRYIADGQQSARPWGNAESKVFTFKSETDNFAGLVESDYKVKAPDATDDPTSSEISNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8W8</accession>
    <name>A0A1E3J8W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031911.1">
        <property type="nucleotide sequence ID" value="XM_019175998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8W8"/>
    <dbReference type="GeneID" id="30193085"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="689" mass="77954" checksum="8F20D97357CF2005" modified="2017-01-18" version="1">MALPGTETIRFRRPTAGPNAVAQSTQAPKKDEFGSMAPVGFKARHQGLLQDQSGRNQRGPFVPSLSLAVRLLLLIRTAGAMYNVIADCDEVFNFFEPLHYFQYNHGFQTWELSPEFAVRSWAYILLHWPMAHLGPLLLRLGKRPAFFALRISLGAICSFSEAKFYRTVVETVNERVGRYLLFIMMLSAGMSFASVSFLPSSFTMYTTMLASTFWFQPATSTPQGVSRTYRATFFYALGAIVGWPFSAALGIPPVFEQLFLSGGEIVPAAAVSQWRTKRWDTMAKATAFAACIAIPVYLIDSWAYGKSVLPTLNIITYNIFSSSGSPDLYGTSPSTFYLANLFLNFNFFLPLALISLPALAVTYKYDFRRLGKSQRKPVEGETSPYLLLATRLAPFYIWGAILTAQAHKEERFFFPAYPLLCFNAAVSIYLIRGWFEQGYVYLTRSPYKASKSQLFSNFTLFAILFPSIISLGRIGAMYQFYHAPFDIILHFQYETLPSVLSELGYEPIAPPKDYQKYGNEEFDIQWDLSPLQDLEEPITLCYGSEWHRFPGSYLIPEGIQTYWIQSEFDGMMPRKWEESAAKDGRWPRSETRVTREGRFNGENKASAEPGNFVDPSECTYLVALSLPSATPSELEPDWVVHPDFEAEFCTPFLDAASSKWWSRLIWLPGGLLESGRVYGNYCLMRRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBD9</accession>
    <name>A0A1E3JBD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032028.1">
        <property type="nucleotide sequence ID" value="XM_019176115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBD9"/>
    <dbReference type="GeneID" id="30193203"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="531" mass="57403" checksum="3B4B86CC01687434" modified="2017-01-18" version="1">MSPRTISKEPERTPTQVDPEAQSPEREGYYDGPEGLERMISVASAGAAGAVQMPDEERPESGFPGLRPAQTNLTTTSNKPYSAFSNGQKWFIVIFSALGAIFSPISTIIYAPAIPTLVEAFHTTTEKINLTVTVYLIFQALTPSIWGSAGDSYGRRPIFIICLLVYLLGCVGSALCPTNAYWLLMLMRIVQSSGGSPVIAIGAGIIADIAPPQERGRYLGIYNLTSTMGPTLGPLIGGLLSYGLGWRSIFWFLVIFCGAVTVPMIFFFPETLRSLVGDGSIPPPLANCTVPIYLHRRKEKKMLEERGEQLPVSTTHRAKFQPWSSFTLLLEPEIALMFLSSSLYYALWYALLTIFSSLLKTEYGKNDVIIGLCYIPNGAGSAISGYLSGRIMDIIILVASILGVAWSMEVHAPMAVPVVLNFFVGVGTGFLTTTTIYGIDSVPGKGGAVTASFNLVRCAFGAVTVSTVQLICDRIGVGWCFVLLSAICVASSPLLLLIVKYGPIWRARRKAKDKAKEAEKKAQGASYSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBK3</accession>
    <name>A0A1E3JBK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032120.1">
        <property type="nucleotide sequence ID" value="XM_019175630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBK3"/>
    <dbReference type="GeneID" id="30192714"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN98258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="43448" checksum="1758A04EF44A2A2C" modified="2017-01-18" version="1">MASPLDPNSLLNTLQGLLPRGTTSPLPHPTDAPAALVHAIHTALGFRLVPSQTFHPHPTPGPNDDREEDVDDNQSEITAVDPDPTDDAPTPNALGQDWNTRGEDSYTFEYRHAQSAMVFRVRVGRMGGRVQVDAMAEDGEPHNLSIVLADLVQPASFPIPSPATASSAESSDGGDAAKKLGFKSLTDVNTFVEKYDREIISKLLPGLDIPGYTQPSSSNSRQPPNPPGSSNPAATRPTYPSLLEDPPLRSGMNPASIGHRDLDPFSGLRPGAGSGFNPGSDGGGMLVDFNHPLFAGRRQGGGLGGGLGGDDITGPGGSVQPPGARWDPVGPASGGIGPRPTPGAGGFGGGVGGGRSDRWGDELAPPGEFGPDLGQLGGRGSSGGGFGGLGGGLGGGLGGLGGLGGRGGRGGNGGGGGGGFGGLGGGGGFGGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBK5</accession>
    <name>A0A1E3JBK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032122.1">
        <property type="nucleotide sequence ID" value="XM_019175632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBK5"/>
    <dbReference type="GeneID" id="30192716"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="330"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="51454" checksum="BA6344D32D75D56A" modified="2017-01-18" version="1">MSKYNITNALMERIHHFASFPQTGVSLQQMIHFGQHPTPGTILKASQFLAEELPIRLSHRVVELDGLPDGLNKMHSIQKVKEWYAQSFEELVSFPKPRFRDLALISESRKPFPSATPNPSLDPLMQEGPSGGTPLPSSRPQGQIIRTLNGTSLTTHKTPPSSQGQHNLAKGHPNRYRPPIERRHYSPPSAAVEYPPEVLEYNEKFTKMLENIKKRHDPTVTAVAQGVLEWKKKQKGGRIGAPIQEFLDRFYMSRIGIRFLIGQHVALNTLQPHPDYVGIICTKANIHDICHEAIENARYVCEEHFGLFSGPPIQLLCPQDLHFPYVPGHLSHICFELLKNSLRAVVERYGADNEDTFPPIKVVVVEGSEDITIKISDEGGGIARSAIPMIWTYLYTTMSDEGLETNIEQSDFNAPMAGFGYGLPLSRLYARFFGGDLRLISMDGYGTDVYISLNKLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBL8</accession>
    <name>A0A1E3JBL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell cycle arrest in response to pheromone-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032111.1">
        <property type="nucleotide sequence ID" value="XM_019175621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBL8"/>
    <dbReference type="GeneID" id="30192704"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="485"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1191" mass="133382" checksum="396F8EC7F00579B7" modified="2017-01-18" version="1">MSGRPVFGGMFDMMYKGAAPSNEPPAEGESGQGGQAQGQRQPNPPTTGFRMGMPLQGFTNRPRAPAMIMKREGEDGPSIGLDQRPFGQQEKKAKPPQFDFRYDDTDTLMNELEEFYPYVEMSDIGTNAQTFKESFDGDWTEAKLSVRKSYIELQLEHFESPNQQIRRLAQGRLLYLLQGCFEETTSPEMQLHWVIENAKAVRAVDGVATIVYGLRDASRRYNSSSWDKPSSGALPSGTVPAQVDPYDDHSAELMDLLAMLYFVVEVLRTDDTFGDELMAITPSLPLILFQMISTLRDKIPRGYPVKKVLLLLWKTLLACLGGMREVQQAMALSRESAGLPNTKYFTKASPIDIANWRRDTSTKYPTFAPPTTSSSSLPSDYSVPHEKLAEGIRPIPPRPNYHSTELPPTLPRAYPPASQGQGEAGYAGNMMPGTPAPSPPPSPAPMVQGPGPQQKKKQQYQTDPSRPFVFPYSHTSGATPLGLVPFAISEADRLYHRHEYISLGLLQMWETREEYMREERGLGRKGLIGFTNGYDGDQEEDEEEVEAMVREWKYEQEEMECESAGDREGARKARERRMASKRLRRVDEIHKKTLPIMHSCMIALLKLLLATVTSPGAGGVNLQNSNLPPGLHSPTQEMPPPATQEEIDISRHREITSKAVSAIIILLLKWFKASHILKFHLLTQMLFDSNCVLLLLKMFGLTEITPVITARNEIEELNFFNYCYLNHSRNPPTNHDPAELRHDRRPSPNDPTPEGAQFSSDYSWRNFFSTINFLKVMQKVTKHRSHRTFVMSSYKSWQILKRMLKVNHPMMQLQILKLIKSQMPWCGRKWRQAAGNMKVITSIYLNCRPELRDDWLAGTDQDSELEDSMPQDNALRTLVSFYNMRLYTPPTPLSPDASSHARRQSTSHNPIFEDPVLNTSQTHFGPGQPQHRRSDSTSGQSTGSEHDVFPPRKSDSPAGAGAGGSYNPDEMIEFWLHEYEDVLGEVFGVEGGNEVLHEFGLASGMASLGIGKGDDDDDAQTPGVEDRAWSRLNEIMRGGNEEDISDSESVVSVGELGDEARMGGTGFGGNREVEEDGEEVVDDGKSRVGMGKGRRRSGAGENTWEHMSPTLALLPRSPIERRRSSSGGSPLRPIVPTSPLNLDPFGHNDVFDEEEEFEVDPRGPMPIKMDTRDHEEREGGAVDEVEYTYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCD6</accession>
    <name>A0A1E3JCD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_03589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032207.1">
        <property type="nucleotide sequence ID" value="XM_019175717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCD6"/>
    <dbReference type="GeneID" id="30192802"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130259" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="24"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="90"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="370"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="706"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="14">
        <location>
            <begin position="816"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN98345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="953" mass="107140" checksum="3305077E4EBD3D9F" modified="2017-01-18" version="1">MPPARHLVLALATFFALLPLALAVKHEDFRQCSQASFCRRLRSIGAKQEAAGKSFQSPYSVADPIPSESGGSWNWHVSSSLYPQIQFELRVDILQQGDGIARVRVDEVESSTPFERYNETARWVLLDTEPALDASASIKTSNGKSVITYGPSSSLSLEIVHSPLKITQLRNGKPEIVFNDRSLFHMEHFRVKDVEAQVSEGEQVVLGGDALDRSWFEESDADAFTEKWKKWTDSKPKGPEGLSIDISFPGVQHIYGLPEHASPLSLPDTIGPNAHYSDPYRLYNVDIFEYLADSPMALYGAVPLVHAHNKDHSVAVLNLVGSDTYVDVLHDKEGTKTHWISESGILDLLLLPGPNPDGLFKQYALLAGGTPLPPQWSTAYHQCRWNYNDQDDVLTVDSEFDNADMPLDVTWLDIEYAEEHRYFDWNKKVFPDPVAMLEAVASKGRKMVAIIDPHIKKTDDFRIYSDAKDLDVLMKKPDGSNFEGWCWTGSSVWVDFFNPKAWEWWTRMFNLQTWKDSTNALFVWNDMNEPSVFDGPEISVPRDTVHAGGWENRDVHNINGMLFHNQTAEALIARESPAKRPFVLSRSFFAGSQRFGAIWTGDNLGDWEHLAGETAMLLSNNIAGMSFCGADVGGFFGNPSHELLVRWYQAGAFMPFFRAHAHIDTKRREPYLFEEPTRGYLKDILRLRYKLLPVWYNAFKEAAVWGLPIIRPQYAVFPDDDKGYAIDDQYYVGGEGLLVKPVTVEGAVTTEVYISDDQPYYDFFTHRLYPSSPRTTLTLHTPLSTFPVLLQGGHIIPNRPRPRRSSPLMWQDPVELIISVGKDGKAQGQLYLDDGEGYGYEQGEFVWKKFELNNGKLVGRDHEESGKKGSAVTVFNPDNAFAQAVADVKINSIVVLGLSAKPRSIVFKSTGAQVEFEWEDGKAAKGKKEGKASELRVKNPGVSVVEDWEIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCG1</accession>
    <name>A0A1E3JCG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032384.1">
        <property type="nucleotide sequence ID" value="XM_019175894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCG1"/>
    <dbReference type="GeneID" id="30192981"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="95"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="489" mass="52594" checksum="C02392318AE264B8" modified="2017-01-18" version="1">MVADPSQTIELQKSGSLHKESSIRSANLSAAHPAIPREGSQVHDATSSAPSGPISTAREHPPMRKRDFGFLPIPQSRRHDPSKAVPGEFPFTWKMNALFASAATIAVMNLYYIQPMLVAIADDLGVSHDAVSKVPILAQGGYGCGILFISPLGDLVRRRQLVLILMLLTTCLTIGLALSKNVAMLSGLSFVVGFFTITPQVVIPWTADLAPAEKRATAMSVTLSGLITGLVMGRMLAGVICVADWRYVYWMAVGLQGLMSIVLWLGLPDTPDKKIGLTYPEVLWSMAKIWTTLTFLLSDPPYQYNSLQIGLLGLLGLIGAILAPFWGRLVDRVHPWSTQFLGIITNLISMIIALAAAQKSIGAVCVAIVLYDVGQQANQVSNGYRVAGIDPAARARLNGCNLLALFAGQTSGTAIMTKVYNSHGWHPTAGTAIAFIGVGIIGMLARGPHEAGWIGWSGGWDVREKQQMSDKSANAVTEKLRVKKKDQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JER1</accession>
    <name>A0A1E3JER1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prephenate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032436.1">
        <property type="nucleotide sequence ID" value="XM_019175333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JER1"/>
    <dbReference type="GeneID" id="30192414"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000336">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="339" mass="36924" checksum="E706E8163697D308" modified="2017-01-18" version="1">MPPPPAKRQRQHVELAFLGPRGTYGEQAARAFASRFHTPVDLVPCSTIAASIKAVYDSPSPHIVLPLENTLQGGVQETLDCLLSSLNPQASKPGAIERQIKLTLSLPIRHCLVALKGTQLSEITYVRSHEQALGQSARYLDEKLPRAKRERWSSTAGAAVSLLESPEEGEGKGAAICSKAVLGLYPDALEVLHEGTQYGDRNYTRFLLLSPPSSPLPKIIPNPRIFSDADRNHIYAIPSVNLTGFLSSVGLPASEGMGEGRYVKMIHTRPAAEGWTAGEFEEREDFPRWHLVEIDGELADDDQLDDDDSDADGEGEGGGYKLLGIVQDEIGHMELSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JER8</accession>
    <name>A0A1E3JER8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032414.1">
        <property type="nucleotide sequence ID" value="XM_019175311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JER8"/>
    <dbReference type="GeneID" id="30192392"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="64001" checksum="586F76CFB941EFF1" modified="2017-01-18" version="1">MKIAVIGSGLAGLTTAYLLRKEGAEVYLIERSPVLGFHSESLQVEEKDEGEKKGRKGWVVNVPMRGFQGGYYPLLISLYTHLQLPIIPQHYTYSFSSESGTYFIHSGASGWSIPSLPSKALTGPFNFLRALLNLLGVAISYLLLVVLSFLAWHDILPSQLSSPDLTVGQFTTHLSSFLNRPLPIPFIGWSPKTPLGYAFESFMGTIVLPLFSAVGTMTHQDVCNLPVRILLEYLHVTLGTAHYRLGKGLASGDVTARLVGVVEEQGEGYVNVGTEVRGLEYAVGGGVRVKLRRVSANGDGDGNREGGGGGGGEEGVESLRVDKVVLATQASVARPLLEDLEANLKTWGEEKERRRVRRMAEALQSVRCRETIVINHKDTSLLPSSPDRRSINLHLPSSPSPSSSSAAPPPAHEDEGETPFFPPSGESVYTMATEVIVPPQGSGGGEVVLQTTNPVVPIAREKVLSVSRLERALALKDPLATLRNLQPHSPNALIYLAGSYVHPGIPLLEGCVASARKVVEGVLEGDRYYHVKKLGEGKGRGEGKDLGVGRKVGKGGIKGKGKRGVGGVDWSVGEGSKVGRVWRWRWNKESVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEY1</accession>
    <name>A0A1E3JEY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032506.1">
        <property type="nucleotide sequence ID" value="XM_019175403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEY1"/>
    <dbReference type="GeneID" id="30192484"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="106"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="427" mass="45469" checksum="1DE60492E57E88D2" modified="2017-01-18" version="1">MPPNAPSERTPETFKILLKKLVQSPDQFTPEDCAECFQHLCAGAFLTALTLSGLDSSPEIVAACASILREHAVSVDNLYSDSHGQEPAPGMWDYRDSDKEGDRYKGTVDIVGTGGDGWDTYNVSTTAAVVVAGAGVRVAKHGSKAATSSSGSADLLISLDCRLAFPVSKVDTFLDHSPFLFLFAPHYHPALAHIAPIRRSLNFRTIFNVLGPLINPSKPDRMVLGVAKQELGDTFAEVLRLLNVQRALVVCGKEGLDEISPAGETWTWWLENGKITKGSIHPTEDFGLPTHPLSSVRGATPDLNALTFRSILASSPAPAHLASPAGPESPSYQAIYDYILLNAAALLHVSGKAASYKEGVQLARESIESGGAIAAFDGFKEASQKAMGEHVDVKTVEDDGGVAAKNGAVKAWLSVNRSRPETPAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEZ7</accession>
    <name>A0A1E3JEZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032530.1">
        <property type="nucleotide sequence ID" value="XM_019175427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEZ7"/>
    <dbReference type="GeneID" id="30192510"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN99453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11779" checksum="850FDC0FE4CBB8D2" modified="2017-01-18" version="1">MSYKPGDATKGAGIFKTRCAQCHTLGEGEAHKVGPNLHGIFGRKSGQAEGFSYSAANVNKGVTWDGQTLFEYLENPKKYIPGTKMAFAGLKKPKDRNDLVHHLEQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFF7</accession>
    <name>A0A1E3JFF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032697.1">
        <property type="nucleotide sequence ID" value="XM_019175594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFF7"/>
    <dbReference type="GeneID" id="30192677"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN99620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9628" checksum="31D0612FC9AE97AD" modified="2017-01-18" version="1">MSLASTILGFSAFGFGARCLQLGIQKRPLFAGFHGHAYASIAFGILGAGAYEADKKQRALLEKKKAVLLEHREAENREWEAQKQAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIS7</accession>
    <name>A0A1E3JIS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032915.1">
        <property type="nucleotide sequence ID" value="XM_019175183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192262"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1325" mass="141794" checksum="6E9603D00E4ECF10" modified="2017-01-18" version="1">MRLVKRRSNLQDGSKPSPSRNHSTASLPSAAASSTDITLTPASTRPSSPVDKGRSRSFRKRDTMGENRYPPSSFASGSGHGWSFGRMRSFKGRKRQESSRDATSESEAESEANMASSSPLPRSSIPPLQPVPRPALPLSEPSPMAAWPAHAPFSSSSQSGLHVSNSQVGLALSTDNLPTAVSYSRVVSPDVSQSCRQFSPLASAHQASSSSKLTKRRPMSMVIDKTLSPVNALSPSSNDPTELQLRRARSSSTSPSNYPRSPPQNLTLSVNTEGSPIPPVPPLPSLSPIINSLPLPEGAAPADPEYVSSLNRNPSSVTSHGSASSAAYPSTEESALIVTPSDRLQRDTMSSLMWDSLRGTELAKIPSEGIDRYHDHDGDLEIARVSSNSPMSKGGSSKTATPNGSIKALRTKTSAADLGLQTYADSESPKITPRRLDRLASPLSPTSPLVTMTPLNGDTFSDDFPTPARVSRLSRPRAASFANSLDTNSIYSLGEVDTATPAVVTRAQQVLLSPSHPGATGVRRGSAPEEHIAGLVEKSEGSPRWHSGRRVLGDVNSSSPQLGYPVREYHSRPAPIPPHLSPSKQDRPQRSPRRTSLPRNGSFSPSSGRESLRVATSQDATLPSSPGEQHKDQVVEMERTLSIGNMLRRMSIGKSPKKGRRHKKSMSMADDGDGGGDGAVADGEASGPGEANEWGVGLGLGGVPQMKEMKRQSFGSALKRKSGMFTAAPELQMSIGAESPVKGGSARPSIVPARQATSEKETASTKISRSKSLPGQKRSPPSAQEVPTARPFALVSTDLVPATATPSFGASRAELAVPRMDSSSSAETGEPYGENAGAKCRVSFLSDQPQSCWPALLGPYIPPELLSLPSYFHTAAPNRSYSPSAPSSPRNRTSLLGPDDHERHAHEVRRRYRQSLVHIKDDREFAHMLEEFARIENDPRARKALGGGISLVSPEASNPTSAEEGDDDGHVLMRSKGRDRESMEKKAKQASIAAWFVTREIVQGESRHAKLLAKGLRVAKAMAATNKFKDKDFAPSSPITPAARSATFGSRSALETPSPAVSPVPRQKSHYRTGSVPSILKKRRNSLTERNSQLLAGSLHALTPSPSALRNPGFPPSPTPISTSSTTSSSQGSAAMALNTLIARLPALLDLSIKLSDAFSNDASPYGVSQAFIEMEKDISREIGLWASEVGGVVISGIMEDLNRAMDEERRRGRGVEEEIDGKEGDERLGYLDIIMMPVQRASRYKLLFQELSTKIPPASTTHHKILGAIESSRKLASTLDTCQAMDLELLRRQGSRTKSLGRKVRPVSIGPGSKSSSLWNGFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIT3</accession>
    <name>A0A1E3JIT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032748.1">
        <property type="nucleotide sequence ID" value="XM_019175016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIT3"/>
    <dbReference type="GeneID" id="30192088"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25031" checksum="4C70BEE7B2984160" modified="2017-01-18" version="1">MSGQDGRQRMFTTQCPTYDFDICVKRSALPPSSPTPLSIPLGESATALQNETLALAYLKDHTSIPVPNIIASFQDRGANYLLFERLEGVIPASSAPPDMHRPILFELERYMDELHSHSSKTCKSFVEMPLFSPRLGHCLRTLSRAEYAPDDKHSYILCHGNLSWDDVLVDCETFDIRCIKNWSFAGFYPAQVEGQYWRRPGPPHALLEAGEEDDVDRVVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIX4</accession>
    <name>A0A1E3JIX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032778.1">
        <property type="nucleotide sequence ID" value="XM_019175046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIX4"/>
    <dbReference type="GeneID" id="30192119"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="32512" checksum="1E9D2F1C7C0DA939" modified="2017-01-18" version="1">MADEKKTQNTKPAEEEKKEEEELDLPYVPIPPPSPSLPTPPCAVFVADCIGNSNVWMKISINGKPFKTSSGHDRIVYQLYDDLCPKTCANFRSLCTGRHPGPNVSATFKALCPGLTCDGSPLPSTFAYAPSTPFHRVIPGFMVQSGDFERRDGTGGVSIYGELFADEKVGLGGPLPSAVRAKEKEKEQKVEEEQKEKEGKEGEGEKEKEGEKKVEKRERLKFDKEGILAMANNGKDANGSQFFVTTVNECEWLDGKHVIFGEVIEGYDIIKEIESRGNKEGKMPRDKILIAAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKD5</accession>
    <name>A0A1E3JKD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032769.1">
        <property type="nucleotide sequence ID" value="XM_019175037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKD5"/>
    <dbReference type="GeneID" id="30192109"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO00577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="41476" checksum="82F3F581C7955018" modified="2017-01-18" version="1">MTVDAQSKTNFNVPEAYQLQEVVGEGAYGLVVSATHVHTGTRVAIKRITPFDHTMFCQRTLREIKLLRHFRHENIISILDLIKPATYASFTEVYLVQELMETDLHRVIRSQDLSDDHCQYFVYQTLRGLKAMHSADVLHRDLKPSNLLLNANCDLKICDFGLARSAAKKDPGAETGNGFMTEYVATRWYRAPEVMLSFQEYTKAIDLWSVGCILAEMLTGKPLFPGRDYHHQLSLILQVLGTPTMDDFNEITSQRSKDYLRALEFTRRQDFATIIPKAKPNALDLLRKTLTFSPTKRITVEEALNHPYVEAYHDMNDEPASEPLPVGFFDFEYSQDKLSRDQWKQMIYGEVTREVNEVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLR8</accession>
    <name>A0A1E3JLR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033081.1">
        <property type="nucleotide sequence ID" value="XM_019174702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLR8"/>
    <dbReference type="GeneID" id="30191769"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000958">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="141"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="876"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO01829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111783" checksum="BCC86FBB91F451E3" modified="2017-01-18" version="1">MTSFNPAPQQLQAAQDRHFSGGVPTPTYMGMVETGAQWDYVGGRGDSRSREASASPHRSATEPPVRQASLPHSSPLVPPQATPVAMASSAPQEPTINEEAAAVVDRSMRAQQTNGTSSNGNGTASPAATKTRSRTRMVGDWQLQKTLGAGSMGKVKLATNVLTREKCAVKIIPRYTEATRREEPKTPEEAEKQRLKDESKEIRTIREAHISLLLHHPYICGMREFIMHTNHHYMVFEFIDGGQMLDYIISHGRLRERAARKFARQIGSALDYCHQNSIVHRDLKIENILISKNGNIKLIDFGLSNLYAPNRHLSTFCGSLYFAAPELLNAKAYTGPEVDVWSFGIVIYVLVCGKVPFDDQSMPALHAKIKRGYVEYPSWLSAEVKSLLSRMLVTNPLERATLTEVLNHPFMTKGFDGPPDSFLIRREPLRADELDPNVINAMEGFTFGTAQTIYADLYQVLTSEEYLNCVSTFEASREKRRGAGGSNSSFNSPEPMDSPKKKRFSGFDFKKRLFKEDKKVDEVVFKERAVDPTRGYDPLISIYFLAREKMEREKVYGPGHFASSQLSLEAFNPSQGYGAQVPHLQAPASTHVMGGHEALPRPRSDYIPTSPTPLMAHPSADGPQSQIEDIPSGAHRRQPSLSQPPLPSGNVVEGGGGGGGMQREEMGLTKKFSMLGKGSRPPSAGSILPGRSISGKREGMSPSPSMPITEHRRATTVHEKKHERRVSAGSFSNNAGRAGGSIVRRPSQREGTAPPATPAGAGPAWLDAPTPAEADEFRPTQLFPSPSPAPPHPPSDHRAPSETYTNDEPHDVARPSYLKGIFSVSTTSTKSAPVLMRDIKAVVDRLGIKHRPIKGGFECVHVPSIDLASVVNGDEASTSLSNVPSEAGGGGGGGGGARRKPSLRKKASKGQLNGGASSTANSRGNSPAPHRVVTGNSSGTVSATLSGGEGTHLSAPTGGGRRHTVNSGGGDEDEVDAWALAQGGGAGSSLIVRFEIFVVKVPVLPLHGIQFRRVGGDGWQYQMLAKTILREMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH4</accession>
    <name>A0A1E3JRH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_02292</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033496.1">
        <property type="nucleotide sequence ID" value="XM_019174444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH4"/>
    <dbReference type="GeneID" id="30191505"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="643"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="973"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO03445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113517" checksum="FD1B4F241B14E4EC" modified="2017-01-18" version="1">MLRTLPRNLRLPSRATLRPKHFSPAQAARKHYATEAVAPSKNDLFANGGNAYYTEEMYRLWKQDPKSVHVSWQTYFAGLDKGLPSSQAFNPPPGMLGAVPTPAGGSPKLSVEGSGDVTDYLKVQLLIRAYQVRGHHIANLDPLRISDADLSSRVPPELKLEYYGWTEDSLSKEFKLGDGILPRFSGHVKSDTMTLGQIVDELKRMYCTHIGSQYVHIVDRGQCDWIRERVEIPTQWQYSTEEKRMILDRLMWSELFEKFIASKYPNEKRFGLEGCESLIPGMKALIDRSVDAGVKSIVMGMPHRGRLNVLGNVIRKPIEAILNEFKGNDDADDTGGGDVKYHLGANYVRPTPSGKKVSLSLVANPSHLEAEDPVVLGKTRAIQHFEGDEGDGSSAMGVLLHGDAAFAGQGVVYETMGMANLPNYGTGGTIHLIVNNQIGFTTDPRFARSTPYPSDIAKSIDAPIFHVNGDDVEAVNYVCTLAADWRATFKKDVVIDIVCYRRYGHNETDQPSFTQPKMYKAIQKQPTVLSIYTDKLIQEGTFTEKEIDEHRQWVWGMLEKAFDGSKEYKPSPREWLSSSWEGFPSPKELAEEVLPHHPTGISQDTLEHIGEVISSFPDGFTPHKNLARIIGNRGKTVKEGKNIDWPTAEALAFGALCLEGTHVRVSGQDVERGTFSQRHAVVHDQETEQAYIPLKHLGADQGSFTVTNSHLSEFGTLGFELGYSLVSPNSLTMWEAQFGDFANNAQCIIDQFLAAGERKWLQRTGLVLSLPHGYDGQGPEHSSGRIERFLQLCDDDPRVYPSPEKLDRQHQDCNMQVVYATTPANYFHVLRRQNKRDFRKPLIVFFSKALLRHPAARSTIEDISGETMFQRYIPDSHPESLVAPEKIRRHILCTGQVYYQLLKEREERGVNDVAISRIEQLSPLPYDLLTPHLDTYPNAEITWAQEEPLNNGPWTYVQPRLITALKQTEHHKDKVPTYVGRKPSSSVATGSKGAHKKEIEAINEGAFGTESQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWC2</accession>
    <name>A0A1E3JWC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033800.1">
        <property type="nucleotide sequence ID" value="XM_019173993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWC2"/>
    <dbReference type="GeneID" id="30191046"/>
    <dbReference type="OrthoDB" id="10324893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="776" mass="85771" checksum="C9FA54EEF0593C9B" modified="2017-01-18" version="1">MSQPSEPPSTPSIPHQEQEPASTDKVAPNPSTPPKTPTRQHAFQPNTPRTPRTPYRPRFTLVDRSPNGRYVARSPPSEDDPITVWGVVITILSFKEQFALWDEIKLDNRLLQAEDVHAGLYTWRMDKKEEDLEMKLGDWLCELRQELSRWLEGEGYVRFRNTMSQFWMSVEDDVTGEIVREGSSDPQLYRPLREWFTNLSNQHYPAGQSPNPVPLHLKITWVTPAPFCLVGLKDHTSDVARSLDVTQKGKITRAEANRCSLAGVLLPDDRIILLVDLCLRSKVTRKSWDATSRLTDYKWDLRPISPPVPTSADEDVIRASIPEPVPYSFDRVHGDASGGAPPYMFTRPYAESYKLGDEDHYHEQEPDKQKALCILVRLTRQLLAEPPKEKIEMRYVSPSRDPEYFVDGADPVSPSPNSEAPDSEKPEESGTDPVYLENAPPSASINQAHGRLPLKPDPLAARSSSSPCKADSSSPPASPTTPTRRRFFHRKASGTGIGDSPSSPHGPSPLSDPHLKSQKGGMQITKRMPPPPPPTFSPPQSLLQPSGDTLLSGGSAPESPSSRDITLDSTTSLVSSASSCTTIDDSFALPSSEAIDGTRQATPSKALPKTPSKTTAGDSFGLPPYVYTVVIKPVIKSVELAKNSKSTKDTTQSAEDTTQSIKDTNKSAEDITKSAEDTIKSTKDTTLQTPGKKTRRLLHKVSSYLSPKKSWYGGHKEKERQEKTGEEMKRQEKIGDKTGAETLQVQNEDQVEYDDTTCEPRGQVEIDRAVAPEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF0</accession>
    <name>A0A1E3JWF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033846.1">
        <property type="nucleotide sequence ID" value="XM_019174039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF0"/>
    <dbReference type="GeneID" id="30191093"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="15">
        <location>
            <begin position="652"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="16">
        <location>
            <begin position="803"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO05191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="921" mass="100806" checksum="96CBF8152AE856C4" modified="2017-01-18" version="1">MSFKKDEDAGMSFYHDKTTVIQEARVFNESPISPRKCRALLTRIVYLLYIGETFSTQEATTLFFGVTKLFQHKDSALRQMVYLVIKELSKIAEDVIMVTSSIMKDMQPNLEVVYRPNAIRALARIIDAQSVQSVERFFKSALVDRSSSISSASLVSSYHLFPLSPTIIKRWANEAQEAVNAKAVSSYSGASAYFAGGSSSNSGYQAVASSSYIMQYHALGLLYLMREKDRMAITKMVQQLGASGKGSSIVRNPMAVCMLIRFARKVMDEDANVRKQMHEYLETLLRHKSEMVNIEAARAIAEMRDVQTGDLYKTIAVLQLFLSSPKPVIKFAAVKTLSKLAQTHPQAVSAVNVEMENLITDSNRSVATYAITTLLKTGNEASVDRLMKQISSFMADITDEFKIIVVDAIRSLCIKFPSKQAVMLSFLSGVLRDEGGYDFKYAVVDAIFDMIKYIGDSRDTALAHLCEFIEDCEFTKLSVRILHLLGIEGPKTSNPTKFIRYIYNRVVLENAVVRAAAVSSLAKFGVCVNDPNVMKSVNVLMRRCLDDVDDEVRDRAAMYIKVLEEKSLADVLVKDEAQFSLATLEEQLVSYVQDEGAHSAAFDISSVPKVSREQAQAEVAQSRPSALDIAGPSSAVVAEPTPTPSAAEAQSSYAAQLAAIPELQSYGPVLKSSARPVELTESETEYVVSAVKHIFKEHIVFQFNVSNTIPDTVLEQVAVITQPSPDSGLVEDFIIPIESLTSASGSGQVYVSFTREQPEEYAVGTFECGLKFVSKEVDPTSGQPEEEGYDDEYQVEELDLGAADYITPTYVTFASEWDKLAPSPSLVETFALSSSESLKEACNSLVEVLGMLPLGGSETPTSASVHTLQLAGLVVPSNGAEGSSKVLARCRMTFAAGEGVTLELGVRAENEEAAKLVMAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWH8</accession>
    <name>A0A1E3JWH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033869.1">
        <property type="nucleotide sequence ID" value="XM_019174062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWH8"/>
    <dbReference type="GeneID" id="30191116"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="35357" checksum="07C5CC35BCBA40FB" modified="2017-01-18" version="1">MSVPTSFKLNTGASIPAIGLGTWQAKPGEVKDAVSHALKSGYRHIDGALCYQNEKEVGEGLRDSGVPREEVFLTSKLWSSFHDRVEESLDTTLKDLGVDYLDLYLIHWPVRLEPNGTHPLFPVKPDGSRNLDWDWDQSKTWAQMEDVLKKGKVKAIGVSNAGIPIVDHIIKTGTVVPAVNQVELHPYNPQHELLKYSKEKGILLEAYSPLGSTSSPLHEDPELLAVAEKHDVTAATVLISYQVNRGVVVLPKSVTPARIKNNLKTVKLDEEDLARLDKIAEGGKQKRFTAPPWGSDFGFPDWYGAGNKDAPEGARLIAGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWW3</accession>
    <name>A0A1E3JWW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034009.1">
        <property type="nucleotide sequence ID" value="XM_019174202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWW3"/>
    <dbReference type="GeneID" id="30191260"/>
    <dbReference type="OrthoDB" id="10375017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="214" mass="22424" checksum="857B3C816F3C255E" modified="2017-01-18" version="1">MGAAHAPATICRFRYDNEAYKCITSYQRPQDKSPVAVIMLAQKALTPAALLAILPFALAAPASNTSSVPVSSSVAAPISSSSSSDEPAPSLYIRLDPFSTIHSHNDNEGDGDGQKRPYGLDGPGEIAFAFGDPEDYTAETFWVRYYKTAGVDPSVTGNFEIPDPTVWATGNPTTVVQCVATATASSKEDADVVPVPGLSTTTGAYQVKCSGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWZ4</accession>
    <name>A0A1E3JWZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-erythro-sphingosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033931.1">
        <property type="nucleotide sequence ID" value="XM_019174124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWZ4"/>
    <dbReference type="GeneID" id="30191181"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="559" mass="60792" checksum="D890A9D50600D623" modified="2017-01-18" version="1">MPPFRHKELQVILQNDKRGILTVEDAALQLLQLSSDGRPPSRLLTSPLKQFLNGQLAPAPSGSKRRLDLHSLGGGTGTALKLVELHVLVEPNHIKEAEEWLEDLVAAAYSTVKPFRKVLLLVNPAGGKGKSRAIVREIVLPILKAAGTIVDLKETTHRSHAEEIAATMDLNYDVIATASGDGLVYEVLNGLASRPDARRALQIPIAPIPTAGSANAVSTNLFGVKDTFNIPLACLNIVKGEQIPIDLCSVLLLPSRTRRFSFLAQAIGLMVDLDIGTESLRWLGDTRFLVGFLKGVVTNKGAKCRLKMKVVEDDKLKMARKAKERVKERKGAEVLGGGQDPLSDGLTKISLNGSASAEPNGHAHPDAHSNGNGVQVESKPIDDGPIPESLPLEPDDSWITIENATGQNKYSQASAQSLRSQPEAQKKGGWVDGQGILYFYAGMMPWVARDLNQWPVAISGDGLIDVVVQSQVPRLQMTNAISGAEHGDPYWLDTQHYYKASALIAENLDKVNQPIFTIDGESYEFDAFHVEVHPRVANLLSLEGDFSTSDFLKKNYEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYW8</accession>
    <name>A0A1E3JYW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034140.1">
        <property type="nucleotide sequence ID" value="XM_019173435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYW8"/>
    <dbReference type="GeneID" id="30190482"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22574" checksum="9838ED21D8B9A238" modified="2017-01-18" version="1">MSNTAPSTADETPPSAGDKRPLDDEPDPQSKKVKSKKAKSKKVKTVPAHPDWNDTSNGIRLVSSDDVAFFVPIYLLQTGSTVFREMFSVVVVQNPSSQTLSPHPSATSATQTHSIEMTDTEFETSGTIHMFLNAVQGISLRSYVNNVPVFDRVQVIESLLRFAQKWESGPALAAYERVLMDEATKSFWKELSRAPRHFCLGGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ28</accession>
    <name>A0A1E3JZ28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034173.1">
        <property type="nucleotide sequence ID" value="XM_019173468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ28"/>
    <dbReference type="GeneID" id="30190515"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27622" checksum="562E9D6A21828F93" modified="2017-01-18" version="1">MAESNQQRPPSPVPQPSSSHPNPNTASLAGDETAQQGELSVGAPVSPVDPEDPDSPWLVETMRVMKESVDRLPSRRLKSTPASSTAVVFGTGEASASSMAQEGHSESPPTAAQFPTSVRQSVIPFPGSRLAPQQGSHALPGYKPPSPPTRGSMSDEDFDRANKELGYQMGPHYGRTTQPDLFPIKLAHLEGTMWNDYLAIHHSIFQLKLNYYRKEEGTEGCLAMQQELALLHGDWRISVLQKKVERRPFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL1</accession>
    <name>A0A1E3JZL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034315.1">
        <property type="nucleotide sequence ID" value="XM_019173610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL1"/>
    <dbReference type="GeneID" id="30190660"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57810" checksum="9F72EB23177206EB" modified="2017-01-18" version="1">MSAKPEKVSKIPTDDDPTQQFTDESGAPATLPEIGNGGEESKLKVLMGLMKKLIGVKDVANLRLSLPASLLEPIPNLEYWQYADRADILAAVGDSSDELERMLAVLRFCFSKELKFIRTRLGKPYNSALGEHFRCSWRLPALALDKESGDPVVRTHVHVPIPGEPAYGGQGGSGWTTPVLRAEDGGKPSSEASSIVSSSSKASRKTKALDLSQVDRSVPGPGPEVVGDPDAGVVESEKVTVVFLCEQVSHHPPVSAAYYYCPEKGIEAYCMDQITAKVSGMSVKVGPGHCNKGIFVRVARDGPGKGEEYQISHPSAAVNGILKGSYYGTISDFIQVTCRGGDSGPTKLRTLLDYKEESWLGKPKFLLDGVIYRYTVGDEEQEGWTKPKQVPSDKIVGYIEGCWMKQIRYKLKGQKEWKILLDLDQLALIPKDVRPIEEQDEYESRKLWEPVTQQLLNKNWGEATKSKQTIEQAQRDKAQARKDNEETHHARYFEPDYEEGRPVLTAEGKEALEKEIKRCRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K015</accession>
    <name>A0A1E3K015_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034463.1">
        <property type="nucleotide sequence ID" value="XM_019173758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K015"/>
    <dbReference type="GeneID" id="30190808"/>
    <dbReference type="OrthoDB" id="2101715at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="324" mass="36840" checksum="AB3A1008D5645814" modified="2017-01-18" version="1">MPLPYGRPWLLEISDQPWCPPYLRDPVRDMLTFLWTHRVPPFQHRAPYEGAVEVLNQVVDEIETYDRDSGIRGETMRIVDFGSGAGGPVRKVEAALNERRLADNNTPVPVSLSDIHPVPSAISDSTSPTLSYIHEPVNAFHAPKSVSSLKHLRTFFLSFHHFNNDHGRQIIADSMRSAEALCIFELQECTLGSVIMILMLAPLTWILTPLLRPSAKTLFFTYLIPLTPLILVFDGLISVYRTRTPKQILYLAKLANLSLALEGEAKDNGDTDWRWEYGYKRHTWPFGRLSWVVGRRDRRDDPGATETETETEGEWSEAETGHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K124</accession>
    <name>A0A1E3K124_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel YVC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034287.1">
        <property type="nucleotide sequence ID" value="XM_019173582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K124"/>
    <dbReference type="GeneID" id="30190632"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="243"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="101497" checksum="C6A9A2E0A42091FB" modified="2017-01-18" version="1">MAYTPTEATPLLGPQSGPSSMILSETKVYPLIHLIRVDIMAHIDAPLTYEQLLAPDSTYTIIRPLTEKYLALQNQATVFCLLLNKIQFTQDSNQISIATLSLTRSTLCEILASRVLRGWSERSLPLATVLLTPWSLFQGASEGVIERAKEEGEGDLLKQTGAALEMAIISGSKRFIRSPSCQKVIEGIWAGRIIYSALNAHALIADNYKKKPIQMYNPHKAPVLDHYRLKVPRYRSMLEYFNFLVLFILYVVAIEGLEGDKIIGREWAFIVYAMAFSLDKLAAIREHGLKVFSSSLVNGFDLVFMMIYGAYMSTRMYGLRYNDIYFMEMGADWLAIGAVLIFPRLAFVTLANNLMVLSIRSMLTEFFFLMGVGVFCFAGFVYALFTLGQGKFDLPQIGWWLLEIYFGLDASGFEHAHYFHPFLGPLLMVSYALLSNTLLLTVLVAILGNTFATINADAAAESMFRKAVSTIEGVKADAVFSYQLPFNLPAVVFMFPMRYLLNDRWFHKVNVFMIRVSSVHILLLIALYERQSYKDQTLMEQLGDFAERYVGSLPRRLKAAAGFDNFASRSDLEAVFEIEREVGSFYAGWDDDLDLDEPDIFLPPAFEDAFADESPEREGAENEDGLGEGQDLFAPQSAPLTASPSRLEHQIESPRPRRNSMPSPHRAVNQAIPQQSSLRRRNSSMHGPSPLAQLFVRSPESEGLPGRRTSLAGTVATSVQPAAPSVFTPPARKRGHSRSESFPATSTSDQSQYSTSSLPRRGYARPSVAPITEGKTVSFASHLKDSEGDGVVEPGAITHDQSENVGAVGPGGVPLGNKTSGTQTQPLSGRSVRFPTVGGHQDLQSPFGTTAFDTRSQSPRPSEKVAKASDVESLAMVKPEEEARSKGVQEKLDDMDKRQKRMEEMMERLLSKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K317</accession>
    <name>A0A1E3K317_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035045.1">
        <property type="nucleotide sequence ID" value="XM_019173319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K317"/>
    <dbReference type="GeneID" id="30190360"/>
    <dbReference type="OrthoDB" id="2572423at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130734" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26283" checksum="A0A61E415525D0D5" modified="2017-01-18" version="1">MLSLELILLTLPLGDALSIPLSSPSFARAAAVEQQDPSPQFMGCTDRGYIQQITNDDSAIIPRLSNEACTMYCSEDSTNKYAYFNDKDSECYCSGEDYPTSSDFRDANNSVGTCQPSQTTVTYLTSPFIFTHCVPSDSYSRPSSNDKSFTASSPEYCLDTCNTTPSSTIAHVQPTYDAEDDWWVYDCRCVSSRQRTKASGGLFVLDNSQRAFDAGWAPEEGAKCGFESVFVYERPVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K333</accession>
    <name>A0A1E3K333_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 6a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034916.1">
        <property type="nucleotide sequence ID" value="XM_019173190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K333"/>
    <dbReference type="GeneID" id="30190231"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="13327" checksum="42B64AA306A6B904" modified="2017-01-18" version="1">MFRAAARSVRPAVRGFSTAAPKAGENAFVANREATRAHAAETTDLWRKISFYVCIPGVIVGALWTYKIEAAHAEHLAHHPEDFSERPVYDYLNIRNKNFPWGRQSAFFNPAVNVEVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K355</accession>
    <name>A0A1E3K355_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01035</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034933.1">
        <property type="nucleotide sequence ID" value="XM_019173207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K355"/>
    <dbReference type="GeneID" id="30190248"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000114">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="55"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="175" mass="18880" checksum="5F6C87697C286817" modified="2017-01-18" version="1">MSPQPSEQHTLDAPALDKLFAAAITYRDRAYAPYSKFRVGAALLGSDGQVYGGCNVENASYGAGICAERTAITKAVSEGQKKFLAVAVTSDIPSPAISPCGICRQFLREFLEPHVPIYFISGTYSSTFHSGGYPDWLGDLTGEEAKKHVKMMTMEEVLPESFGPDHLGLAVTDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K368</accession>
    <name>A0A1E3K368_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035105.1">
        <property type="nucleotide sequence ID" value="XM_019173379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K368"/>
    <dbReference type="GeneID" id="30190422"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="16661" checksum="0C6447D73ADA7407" modified="2017-01-18" version="1">MSDRGSNPPEEKPKPEEPAADPNTLNIKIVSTNGEEVFFKIKKTTKLNKLKTAYADRVGTDAGSIRYVPSPLLLLPAGYRSLCPSLSLSLSLPSSFPSLMRHIHLSSFVGWMGFGINRLIFDGERILDNQTAADLDLEDGDSLDVVLQQVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3F5</accession>
    <name>A0A1E3K3F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035052.1">
        <property type="nucleotide sequence ID" value="XM_019173326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3F5"/>
    <dbReference type="GeneID" id="30190368"/>
    <dbReference type="OrthoDB" id="2573153at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="608" mass="66329" checksum="166B13D5B7A7D1F3" modified="2017-01-18" version="1">MPEKKYALARVSICDPRLVPAGTPPKDIKWESYVHCTISATPSPDGSSLQLEMRTSSTSLVSRKFLPLSTLQSPFRRITYTDKQAAFRYDWPAESPQPPNTKTMQECFQLIFKKPTDLIALLESLGPFFSATPSTIKPITLTVSQVPPSKSAPKATLKKSSAAKKKIAPKPKSNGKKGDGGDAMTVHRVGGPANPSAVDDNRTRPADSTTLPSSNQGPSRTPLTPSSLALNQAGNQQTRPMVPLHVTEIAPRPSPTRPPSTSTSSALSTPLGGSKTTFPEDPDMASLKRKLLAGPGLASTGPKVAHSKFPPARLAPAPSVVYPPFTTYKPQSADNAPSQPQQPSSQLPSSMALVKPPTSPNLICLSSPLISTAPSPPRTALKSNPLDDLLDLDSSCMEFVPIMTREQEELETKRRLEEEDLDEEYTLPNDGNDIPPAHQAFQATVALVVAFGSPLHELGEEDMDDLISTCMASDGFDLLYRKVSYLLSRRDSLQLCAPATPSLGASFDLDDMPSSRVLTPPTESYPLSFFDQPSAFSQDRSGQYYDFSQTDTQPSFVPETPGYSYSSKRSYCGDISEYDQEKRMRMCLEEEEEEEDVYDDLEEEDMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4W3</accession>
    <name>A0A1E3K4W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aprataxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035024.1">
        <property type="nucleotide sequence ID" value="XM_019173298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4W3"/>
    <dbReference type="GeneID" id="30190339"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="310" mass="34784" checksum="35B46979B4D9A0F5" modified="2017-01-18" version="1">MGNCVSAPSSSSSPSDIPPPRRPALSTDGSSNPSPSPSSQGPQTPKKGKGRALSHRSGLSTSSIMASHPLLALRHYATLSNPQTSLPANKLLFANYNTMAVFDAYPKARYHLLVLPRYPFSSQSDPDGDESIVPLEALDDLKSLLLKGGEYGREEVLRAMEETAREVEEMIRDEMLKTEGFAWRVDVGFHAVPSMKHVHLHVISDDRISPSLKSKKHYNSFRPDLGFFIPIMEVRRWLQNEQTLQERVDALAATTSLLKTPLTCFKCDEPMNNIEKLKTHFEKEFNKERKDALRYITRYGHQKGSDDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5C0</accession>
    <name>A0A1E3K5C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035255.1">
        <property type="nucleotide sequence ID" value="XM_019172313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5C0"/>
    <dbReference type="GeneID" id="30189341"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49677" checksum="2184B98FF71B153B" modified="2017-01-18" version="1">MDPLQTSAENPEREVRALPAVDTSREAWLYVFAGFSMEMLFWGPMYSTAVYLKEYAAMPLFKDVSETEISLVGTLGLLFGYILSLPLLYFYNAYPRAMKPSLWFGVALYVVSMLIASFVKSMPLLILFQGVGPGIAAALTASPIIRWIPEWFDKRKGTAGGIIFAGGGVGGVYMPFLFEFLIGKLGYQWSLRITAISTATIASVAVFFANPRIPISSRARINRMPMPPFFTTYLRWGFLCTFLCTMFQSFGYYNVNLFLPRFSDTLKGAEGAGLLAAFNVSCIGSQIIWGLLTDRMKPAAAMAISSSLGALFVLTLWGFGGNQGLPVLAPFAILFGLAAGGFCSMWFQNAGDIAGPDKEQQSLLSAGWSIARGVGAVIGPTIGSALYRTPSVPGSNRWGSAGSPGLVGLVAASLAGSALVVLVFRYAESAVKALRKYRNGEMERRRVGDFGVELVERST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5D3</accession>
    <name>A0A1E3K5D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034929.1">
        <property type="nucleotide sequence ID" value="XM_019173203.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190244"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1652" mass="180299" checksum="0EB49CBCBFD852D7" modified="2017-01-18" version="1">MAQPATLPKAGRTSSRPRNPPGQSVLSRAYAEGRASQDALERPQVTHPYAHPQVVNPGLPSHSPPPPPSQHYSGYSPNLPQNPPAQHAATAPLKLRPRMSSAPVTQTQNQGPLFSTTLDSPTEGPRLKPRVSSRPRAPGSKSPVVFVGREGRPSTDMGGRPSADMGFMRRPSLDAADVLDHRSYPAPGRKKSHPTDYGQPHNSGKQQPTMVPLKEMTSDRPSMNGRAMSAPPADVPSSPPRHNHFPAESSTTAQKKWKKTQQGALGVGHGPSRSTGAPSKSFDMERQVSGTKSLDVVRDLDGGLSGDEEGRRPSGSKTNMKKKSTAALRALFGRGASGKSKKMEEAPPMPEDRYESRVTSNSSQREWEQSTTGRSGRTTPTPKLYDGRSISTFSSNDGGKTPTAQSSSSPASSRTNPPARELPIPPRPSPSPSPNTLSAPSKTPPASPPASLHVPRATTPVFDPSTSPLLSLSIDESPLFASSSPKKRRPATADNKPRTPPRLPSAQRLQLPQLDLDFGLEFDFYGLSPSSGSRKSSPRRERNSPLASPKHSPARSHSYRSPGRPSTSPGTLQRSWTLHERGSEAGSPLALSTVSSRSPVPGARRQNDEVFGGRLAPVSEMPTQSARSPSPSAVPFLPNVPSSDDITSTDSTHESTSPALPVTPRESNATLGDVAINVSSSSITASSTTLAPKSVPELPPKEKSPVAPTVTLPRIAPPALTLAPPVDITPPNPIIIAPPPPKAKPIARQRTLALLSKSTPVIPDKHLTISALASKAEDIRVAFKYPEAGVSPSDRSASLRAELVPLIAEADRRAYDVAKEDDYEVLRSVFLRWINLLISELRFDRPVDERGAVLESLAALFESICLSEEALQLSDDHQSKITQMMVRCMSFVMEKLGGRGVFQNILVFSGRFLAFAFFRVPHVAHQLLTVLSLPKGALMRFAGNIENVDCPAEVQPKYPEHLQPLIFDNVMSYNSRLNAFTAEFETDEEREAFLFPPGYWLRRWQSDDSELFPSFYRAYHRQLAHYLGPVVKHFEAQNKPIPVGILMRAPGYAHLSTAFAKKLYSYIANTVNAVTTCSTSSNFDATESALQAPNAKPPVLVTANRRLTETLLTFSEQRISIPAGKVIIDCEMSQLYMGMIDLWTKNLITKTSLNAPKGVFCLFDLLDGIIDPPYGFIPGVPTRLDTVVDVPFLINVLRIILTETEHAMTLVKAIAFIFSHWEVLTARSEDRKELCLDLLLQKELFERLLLFWSHSVRSYVLRLVVFRLGHLEAANSKSVGWQIEVQTVKVLETRLEGIKRRYDELEPGAADSEPLPDKRISHVSPREEIEEPSMPRSRSTITMVADEPAPEPNEKGSQEKAERLLGLGMGTIDAPRGNVEVDPVTGSNKFGKAAKWLKKNFKNKDKTNSKNKNKDKSVSLGVDGSPTVSSDGDSPGQEQGELSEGSKPSPLVPPSTPPKSSQASSATASTAAESTTTSPSTPPNRKPKPPTIVTTPSGERAERRRSRGAFTFEFDLPAMSPRSDAFDPPPTPTSPRRNSQPPPPSPRKPQSPHMSKSFSKRSSLLPPSTANALEAMLASEREKEREKKKAEEKLRQEKGYDKRLHPYAIRMLGELEDAQKEYDEWWSDSGYGKLDGLPPRLTVAWPFHENED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5M8</accession>
    <name>A0A1E3K5M8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035246.1">
        <property type="nucleotide sequence ID" value="XM_019172304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5M8"/>
    <dbReference type="GeneID" id="30189331"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="65448" checksum="3FF0893266FB161D" modified="2017-01-18" version="1">MFKKPLVHQSNATPIRSSARRQLLAAIFEQFPSLVASTDDNDKKELGKLILPEGVKTGTFENSTGVEGTFWIAPDGNPLWMSFGRNSKEYIPTLYLLTLPLPRPILPVIQIYHPMPPPILTGAPLFIPAVRNIDKPHLLPDVQKDRLVAFATSPSRNDDVHYVGVGRIAADGGMRGAWERRIQLLQGGEEKEEGKFADVLCIIEDHLWELGSKSTPPTFALPAPEVPLASAPGGKAKDDLPPIENLAVSGDATGESSEPTISSAPLTPDEISSLLSLSLLQALSSLQPSSFPMPASLLYSSHILPSRPSYIPKDKRDEVVIAKSEWKKLAKWMKEINKEGIVKIKESKGEVTVVSFDPKHPDLQAYEGYTTIAQEEAKAVKKAAREAAANPEGADGKPAQSASQPIDIQELWKPISPALFFWEACGLSKSEYYPPSALRQTLDEYINKHDLIVPSNHRFVLLDEELGKAVGVKKPDPGQSMARDDVIAKLRNGVSWAVSIGGTIKKGALQPITLTIKSRGGRRTVTHITGLELFSIPAESFAEEMRKKCAGSASVQPREGVSPKLGLVEVQVQGSQQKIIIESLVGRGVPKRWIKDEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K647</accession>
    <name>A0A1E3K647_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035504.1">
        <property type="nucleotide sequence ID" value="XM_019172562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K647"/>
    <dbReference type="GeneID" id="30189594"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="27376" checksum="9D887679B5C1AD1F" modified="2017-01-18" version="1">MKSAFTHRHLQDISTRLIPISRTPPLSRLPPHTATYDRGRAPKESGVLIPLMNIKGCPHVLMQVRAHGMRVHAGEASFPGGKADPTDRDLMHTATRETEEELAIPPSHVQLLGGLEPEYSLGNKSRVWPLVGFVHSTPNPWPNDPNSSLPSQPISSLVPSPDEVSALLPLPLAILTDPARLSTHNFRLNWYKPYHKIRVEDLVIPPAPGASLDVEGLEVWGLSGWFLNKLCEKLGWLEPPEVEASPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6I3</accession>
    <name>A0A1E3K6I3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035653.1">
        <property type="nucleotide sequence ID" value="XM_019172711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6I3"/>
    <dbReference type="GeneID" id="30189744"/>
    <dbReference type="OrthoDB" id="2581860at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65595" checksum="066EEA8D81FFBB40" modified="2017-01-18" version="1">MLNILSRVANDMPRDSMPLGGGESPSLPFDRERFLDLYQQASGTLDPDPFMGMAVLEQGLDQLFGGQEQDTDIKQGEEGIYARIDQPRRDLEPHLDPVTNGLITEREARDLLSVYWSRCHPITRILDPKIHTMDYMRATSCGLFTSVLQVAAQCLPVSQHSAGIVARLDNHIDTLYQIIARKGMQSLELCQSMLIHNAYIRANKQHQTWPNVSMSIGMALETRLEINTLPAYMFDDPIYAHISPERKRRNIQRFWLVLTDSDRKMSFIRGRRPLLRDNVIPSMLNLEKWYQEADALPCDVVSCSSYAFQNSVATLQRNIQRTMVSQSAFTFEMHMKRVDDTLNQWRKTWYNRLSRDDQMRAEHDLRATRFALLMTPYEHRLNTGEMKEIEHDECLVAGLDLCKDAIPFLGGAVQNITPGRLYLVGYVSLCTLRIMDATRKNEGGHTPDISVFHLSILSALSSRLRDIKAHSNIAVIGSVLGRRLLCACRKVAASTLGVAMDMPTPISEDALNLLGQDIPGPGSTDLSGIVRGDVPESLGGIGSLGPLDLAFSFDFTHLGDINPFLENDFTDFPSIPFAPLPPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6L8</accession>
    <name>A0A1E3K6L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent RNA helicase DBP8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035693.1">
        <property type="nucleotide sequence ID" value="XM_019172751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6L8"/>
    <dbReference type="GeneID" id="30189784"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="176"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="428"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="610" mass="66524" checksum="D8CCD23745A64F3F" modified="2017-01-18" version="1">MAGSTKQAQNKGRRSSPKPASDELVLDQNEIMRAMLAMQKGKQREGSDSDDESERDESEGDASEEEAEGSASEAESSTFAQQNLKRRRSLSLSLGEESEPEAAQPARQTQGRVGVSRTATSTKTPLKTQPKPTGLQSAPKPAAGTSFEDLGLSQPIIRALASISITKPTEIQSACIGPIMAGRDCIGGAKTGSGKTMAFALPILERIARDPFGVWAVVLTPTRELAYQLTEQFLAIGKPLGLTTTTIVGGMDSMKQAKELEGRPHIIVATPGRLCDLLRSGGVGSGKLSRVKMLVLDEADRMLTPTFAPDLAYLFSQVPAKRQTCLFTATVSEAIMDLANKPPPPGKEAPHVYRVASDTLTVANLKQKYLFIPSQIRDPYLLYILQNPLEDIDIALRIDPKKAKAQEREATMGNKRGKKSRSDPEPAEESQSIPSTVIFTQRCATAHLLHLLLNSLDIPSVPLHSHLTQPQRLLSLARFRAHEVPVLVTTDVGSRGLDIPEVAMVINWDCPRRADDYVHRVGRTARAGRGGVAVTIVTERDVELVKVIEDEVNVQLEELKLNEDTVLEGLNKVSMARRLATMEMHDSGFGERQALNKAKQIKRQKRDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9Q3</accession>
    <name>A0A1E3K9Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035827.1">
        <property type="nucleotide sequence ID" value="XM_019172885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9Q3"/>
    <dbReference type="GeneID" id="30189925"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="72" mass="8194" checksum="B4DD3D61F250CC6D" modified="2017-01-18" version="1">MNSNPQQQQHQQYYSYRTTNSAAGTSAPDNTNPNTTTSSTPTFSRRNEQDELWGGMTRRAFKDRFAAAALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ72</accession>
    <name>A0A1E3HJ72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027956.1">
        <property type="nucleotide sequence ID" value="XM_019180055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ72"/>
    <dbReference type="GeneID" id="30197294"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12047" checksum="20101BE1903736C0" modified="2017-01-18" version="1">MSSSQQSYQDTSSQHTDGAADSSASKPSRGAPSKQNRECARRFREGQATKARDLETKITELESKTHETHAENAELRSVIASLRSEIWSIQEEMEGEMVEDDEDDWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJF8</accession>
    <name>A0A1E3HJF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027993.1">
        <property type="nucleotide sequence ID" value="XM_019180046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJF8"/>
    <dbReference type="GeneID" id="30197285"/>
    <dbReference type="OrthoDB" id="2575404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18137" checksum="3F15A3971D15BDE8" modified="2017-01-18" version="1">MAERVLAGEDESGFTHLASLDASNAINRLLHTYLSRVAGAVIHLEPPTQTWQRRNDLRVRGGGGALPNIIYDLKVYGLDDKNMYVVQGGKPRDTEWLEWVQGRCVAWLGKRDEEVVSHQPRIYAGGGAVPPPRSFCGRFDGRGDGNGREELEEVQGEGGLARIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJM8</accession>
    <name>A0A1E3HJM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027936.1">
        <property type="nucleotide sequence ID" value="XM_019180082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJM8"/>
    <dbReference type="GeneID" id="30197322"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13012" checksum="C40869B520E573A2" modified="2017-01-18" version="1">MSFLSPESEASIKARIKTTLVPCSSINTPHVPSGTTEIPVSDTSLLAYLTVPAVLVFDGLIDETRLVRAIELLTGVWPTLAGRYKSVGEGDKTKFSIELTSSPIPFEAQTLERDRAFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPD1</accession>
    <name>A0A1E3HPD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028066.1">
        <property type="nucleotide sequence ID" value="XM_019179944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPD1"/>
    <dbReference type="GeneID" id="30197182"/>
    <dbReference type="OrthoDB" id="2594643at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="869"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="954" mass="100558" checksum="24906BEBF467445B" modified="2017-01-18" version="1">MGHEAPRDDLDPALALGPFFLGFCLESFGMGVVLVLSLNYLIAIRTRPRAPADSDLKCSACLLSFCLLCNLAQTLVDLARGWNMFAENFMNIRVVTTSTPLFFISLFLGLIPTTITQLFLLRRSILFLTSLSHLWPRLSHPVSKTLFAALMLAAIGTSFVSGTITSVLTYRVGMLWRLASPQQKVGRLFQTVEMIWLGTSTGVDGCISGVLCMELWWARSKLGIEGGVMREVVTRLILVTCNGGMAVTALQAISLLLYRYSSHNAFCYIPITILPKVYNITLILSLALPHSSAQRANQPNHVFSLPTILDFPRSPSSRSPRSPRSLQSPHTPRGRGAYPYPYGREGREEGRSPVSPKGRSSSTLTLGPTRRRAGPAVGVGVAERERGDVGKEKERYPSMRYAFTSGSSLPLPPALSGARSGTGAGSGSGVGMGGGGGGRRTSSWFDLSSRLRRSADFEGDRGRGEHEECAGAGGGSGIGSGSGSASGSGERRGSSWHGPDINASDEYRRRPSERSIIPLLHSPASAYSASASYPTPSSLSSFPSPNSSTTFSYPLGLYEPLNLVPPAFSDSSSSTKRKRLKEMEKETEKEKEKGKEEGPVVLPDDHPLYHPAFTLPSVQVPKKSLTVGKAHSFSDTASWGGGGGSSLSLSPGAGSGLGLGLGMGLGMGMGMGVGGMGVGGGMVDSPLPYVYEKEEDFWGPHPHPRPRRPLSGLGGSGSGGEGSGSGEGTGSGSTWGGSGDPLLAPSSWSWSSHSNSHSNSHSHSHSHSHANFHSNSNSQSCDRSAAHPNANANANACDPIDPIDPIEEGYEKQPSCASSSSSIAIAHDDDALESGTRPKGRAGVEVDGEDEEEEEEEEEGGTPLPATQLSLIPSSPSSPSSPSSPSSPSSPSSPSSPYSPSSRSLPLSRSSHTISTNTPNTSNCPKRLSLSGRAAIIAEKRSKEIGEEEEDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYN8</accession>
    <name>A0A1E3HYN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028236.1">
        <property type="nucleotide sequence ID" value="XM_019179755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYN8"/>
    <dbReference type="GeneID" id="30196978"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="408"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="533" mass="58067" checksum="05290367B7735F26" modified="2017-01-18" version="1">MQLPQPRFNNKLRSYSAADVVSKRGTLKLLYPSDVQAQKLHKILESKARGEGGCCTATYGALDPVQITQMAKYLETVYVSGWQSSSTASSSLEPGPDLADYPSNTVPNKVAPIFTAQLFHDRKQRSYRSQARAAGESLEPPVDYLRPIVADADTGHGGLTAVMKLTKMMVESGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLLAMRLQCDIMGTTNLLVCRTDSEAATLITTNIDPRDHAFILGSTNPDAGELNELMLKAESEGKSGATLQAIEDEWVGKAGLKLYPEVLAEALEEQGVDKSKIAEFVSKVSGTAHASHSATTALAKSYGLTSLPFWSWDTPRSREGYYRYQGGTQCAINRAIAFAPYADLLWMETKSPIYSQAKEFADGVHKVHPGQWLAYNLSPSFNWEKAGLGKTEMKEYVWELGKLGFVFQFITLAGLHSNAYINDLFAKSFATEGMKAYVELIQGREREIGCDVLTHQKWSGADYADAMMMTVTGGVSSTAAMGKGVTESQFGGDDKKSSHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I151</accession>
    <name>A0A1E3I151_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028279.1">
        <property type="nucleotide sequence ID" value="XM_019179732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I151"/>
    <dbReference type="GeneID" id="30196955"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="25372" checksum="DCC38DFE3BB9D3AE" modified="2017-01-18" version="1">MARSSTLAPNVGRLSRSQVAAKRGLFKGKKTAQAPAKAEAPATTEKKVGGAKNGEKRLVPTSKASKYYPAEDVRKPKISRKTAAKTVLRNSITPGTVLILLAGRFSGKRVVFLKQLDSGLLLVSGPHKINGVPLRRVSQAYVIATSTKVDISAVSIPESINDAYFTKAKAAKSTKEGEFFGEGQEKKAFPEEKKAEQKAVDAALIASIKKVDNLSKYLKSSWGLSKGDRFHELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I608</accession>
    <name>A0A1E3I608_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028393.1">
        <property type="nucleotide sequence ID" value="XM_019179625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196846"/>
    <dbReference type="OrthoDB" id="2591140at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="667"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1366" mass="152469" checksum="E46B98C1CE0A7FFD" modified="2017-01-18" version="1">MDIIHRLNPFHRPSSSLSRNTPTPFSSRGRPSSSLEHGYPTPDTTPHPSFDISHHPSVELGRHSLTPTPTFLNTPREEDEDDAQRKLGHRRSHSLLRNLTSHPSLSALKAKSTRGKKKANRRKGIPLMPTDPNGQYLAPVDFGEAERPGTPGKLRKGSLKGSKSLPRDLRFSGEFQALDSIPPLPEASTYDTSALTRSQSSAATSRSGSTSPFKKRNTIRRKPAPSQPPEITVYHDCSSTPESMRVRMRFEVDMNSNYSGSPSRRRHKSFDVRSSSPSENRGVRDQTGRHLSSPPRAQAGPVGDSWGVSDYAFPRTRQHPHPVPIIQEQRVFAQSLYADSTTFFSPGDIVPVTASGRTAITDEPEDMDPFGSGEESLLETPRKVKSARDLGVSAEHGAAQSSPARVFSRDMYGSPSEDSTSSTSHSTQLLSPTPERIGTHRRAESSPSPGRKSREAFLRAAKRSSSPFEIKLSPHVTRRMSLDAFGTPTAPTFTNSHEKEEGVEELAEYEESFEEEVSWEENQLSLQDRFEDQQVTQVYEQDMRSYDEVLADFQATELSTIMESSSSRGHESQYMSSEGRLTRRSTPPPARPSWDLFSERTQERLPTTPGLSSNGLPLPSPTPTTPLIHKKYASAPPLVGVSPQLLDAHLEHSQSLQDQVKAGVTMMEVLKSEVAEMRRRLAKEREEKEKLLAALEEEREEKEELGVFAEGRVIDLEEAHRMSEAKDQALEQLRQAMAAHERTLEEIREDKVFYEERCENLEGENEHHLFAKQTAEQCLLEADNENEELKRELRELQDKNDKLSKGKKAADDVVCDLKSELKYVESRLADFEGCEAQLRDAEAEVLELRGSKERAAELAKDVKRQTRRLAERDGTISTLRLEMSSLKCEILDLTESSQQLAASKALVKEREASIASLTAQLADLQNQLTSSQIDAQADKLLLVTKDQTIDELNEKLRLVRFETNEKHFESQEALGKMRGQVEESSRLGAEREMAGMRANEMLARLMEEKRGWDEEREELYETLNRAPTGEEESASELRSEIQELSWQLANTMRDLQSLQDQLDVQDASLQHKTALITTQETELSNLRHALVDAEESVAHSKAASERQSKDSERCLERLREQVQELESRLCSHDSALRSAVLEAESGKVSSQDSKWRIERYMADIDELKLSETKLRTQVEELRRQSAMGEVARVDLEKKVGKLEQDKELLNVALESKQMEVVLLQRKEKHRAPTPTRSALRPTHSALADSISHIPPTPTPSSGLDHTPLPRRLATSTSATPASPRHRSNTVAASRPSSTRIPLGASTRHNRVSDVSRMAAAGKAPTAKQVEPAAEKGKGVVRRTSLPVLVARPGSAATGALQSVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7G4</accession>
    <name>A0A1E3I7G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028348.1">
        <property type="nucleotide sequence ID" value="XM_019179660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7G4"/>
    <dbReference type="GeneID" id="30196883"/>
    <dbReference type="OrthoDB" id="2562681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="24723" checksum="589F3A3F0C81131D" modified="2017-01-18" version="1">MAIAPLSLWNTLWTTLYSHAPQPPWIALSPGQPLSPRDTYPAAVQKDKHSRSGLTKTELAHKSGAGRHNWGSLRTKGDDESTGRQDGDLEVLDEPIPDEATDIFVFESEGDEFPVGRNLASDAGNDFKGLNIQQRDAKFESQGVATSPTESTGSLDSVDRPDLGRRGSSVTDQEREKARHFREGVLHKKAGRGIDLADIAKTSYGIAQSPPTNSYIGTSPSNGFHLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICF6</accession>
    <name>A0A1E3ICF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette, subfamily F, member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028664.1">
        <property type="nucleotide sequence ID" value="XM_019179308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICF6"/>
    <dbReference type="GeneID" id="30196513"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="70"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="382"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN86287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="68640" checksum="4A855BC531CDBF3A" modified="2017-01-18" version="1">MAPSASKQKRLADKAAKAAEKGTTSSKSSTGASTPVTSVEGVTEEMAKLQAATDRGASGVLVSDPKGRDIKIDQFTLSFHGRLLIEGAEIALNYGQRYGLLGENGSGKSTFLESIANRDVEIPEHIDIYLVSGAVEPSDVNALDYIVASAREKVERLEKLAEDMSTADEIDELGLEAIYEELEEMDPSTFEAKAGAILNGLGFTQAMMAKPTKDMSGGWRMRVALARALFIKPHVLLLDEPTSHLDLGAVVWLEAYLSTYNHILVFTSHSADFMDTVCTNIMDLTPKKRLEYYGGNYTIYTKTKSENEVNQMKAYVKQQEEIAHIKKFISSAGTYANLVKQAKSKQKIIDKMEAAGLVEKVEAPRLLRFNFEDIRRLPPPIVAFSDVAFSYSGDKKDYLYEDLSFGVDMDSRVAIVGDNGTGKSTLLNLITGALQPVEGTVNRHTQLKLAKYSQHSADQLPYDRSPVEHIAALYSDKFPDKDIQFWRQQIGRFGITGAHQTNPIKQLSDGLKNRVVFAILAMEHPHIILLDEPTNHLDMESIDALAKAIKEFEGGVVIVSHDFRLISQVAEELWEVKDHKVINLTKQDISIVDYKKALAKRSQHQIEKAKLISKSASKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICH3</accession>
    <name>A0A1E3ICH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette, subfamily G (WHITE), member 2, PDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028689.1">
        <property type="nucleotide sequence ID" value="XM_019179333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196541"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1479"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="148"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="857"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1505"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1531"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN86312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1559" mass="172898" checksum="C237D13BEDEA1B34" modified="2017-01-18" version="1">MAFTGATVAGNYDRTEHASGPALARTTSRSYYDSHPSDDLPPQTHQEREQELHHLARTLSRSSVRSPTANAPHRTLTRDTVYENPESVFDYEKGSDLDPFSDKFDAKKWTRMVFQASQGSQPTRQAGLSFKNMSVHGYGSDAGKYYQTTVSNIFQKTFGAIRDQISGNHRKVQILNGMDGVLEAGEMLVVLGPPGSGCSTMLKTVAGEMNGIFLDEESQLNYRGITPKQMYGQFRGEAIYTAEVDVHFPNLTVGQTLAFAAKARAPRTPPGGLSQAAYAAHMRDVIMSVFGISHTVNTIVGNDFVRGVSGGERKRVTIAEASLAGAPLQCWDNSTRGLDSANAIEFCKNLRLNADYMGITSVVAIYQAPQSAYDVFDKVSVLYEGEQIFFGKTTEAKQFFLDMGFHCPEQQTTPDFLTSLTSATERTAQPGFEGRVPTNPQEFAAAWKKSDKYRELQEQIQSFEAKYPVHGEQYNSFLESRRAQQSKHIRPKSPYTLSYAGQVKLCLHRGFERLFADPSLTFTQLFGNTAMALIIGSVFYNLEDNTSSFYSRGALLFFAILMSAFSSALEILILYAQRGIVEKHSRYAFYHPSAEGVASALTDMPYKILNCILFSLTVYFMTNLRREPGAFFFFMLISFALTMVMSMLFRSIASLSRSLSQALAPAALLILALVIYTGFAINVSNMRGWARWINYLDPIAFGFESLMINEFHGRDYDCSVFVPSGGPYDSVDASQRVCSTVGAVAGSSVINGDMYINESYSYYHAHKWRNFGILIVFFLFNTFVYLSATELITAKKSKGEILIFPRGRVPKAILARSTESINDPEAGGYAGGSRAAKQLTGADRADAGIIQRQTAVFSWKDVVYDIKIKGEGRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRVTMGVVTGEMLVDGEQRDISFQRKTGYVQQQDLHLETSTVREALRFSAVLRQPKAVSTQEKYEYVEEVLKLLEMDAYADAVVGVPGTGLNVEQRKRLTIGVELVAKPALLLFLDEPTSGLDSQTSWNILLLLRKLTEHGQAILCTIHQPSAMLFEQFDRLLFLARGGKTVYFGEVGAGSKTLINYFEKTGAPKCPPNENPAEWMLSAIGAAPGTHTDVDWHQAWLDSPERVAVRQELSRIKDTKGGKGDAANKEDTVEKSAAERKAEYAEFAAPMWQQFVVVTLRVWQQHWRTPSYIWSKIALVVASGLFIGFSFFKSGTSQSGLQNQLFSVFMMFTIFGQMVQQITPNFVTQRSLYEVRERPSKTYSWKVFMMSNVISEIPWALLMGLLMFVTWYYPIGYYVNAEPTNSVHLRGALMFLYIESFMLFTSTFAVMIVAGIDTAETAGNIANLLFSFCLIFCGVLATSDQFPRFWIFLYRVSPFTYITEGMLAVAVANTNVVCATQELLSFSPPSGQTCGDYMGTYISAAGGYLLDASATDACQYCTLDSTNTFLAQFKIYYSHAWRNWGIIWAYIIFNIFAAVLIYYIARVPKNAGKEQATPDDEPTRTTTNTKTVPAAPSSEGTTVASDTATEKHAVRSSAEGAEVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID86</accession>
    <name>A0A1E3ID86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028723.1">
        <property type="nucleotide sequence ID" value="XM_019179242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID86"/>
    <dbReference type="GeneID" id="30196445"/>
    <dbReference type="OrthoDB" id="10313852at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="319" mass="36804" checksum="A11B6657D7546C94" modified="2017-01-18" version="1">MSILPLYYQDGNHSGGTVHHLVYPDENPEVFEMVRLQHGSTLPDVPSSEPVYVVEYPYPSHSRATAVSRLPPLRAQPGLTTLEPLAPVHHLVLLLLLQEEYLGPSRTMALSPTVFHFVKYDVYRSVTMSRDLLKGLDGDRKSRQRKLDCLECVHELYIDSMDALWDLANLHSPQRSYMFKSFFSIMPNARTVHIHRRAIVAQYTLRKGKRAEEPVPWSWLKEGVMRQLGESVEVRFYGEYDTDCTGQSVFARVTYALPGKLLKSQESAEELEERRLRRKEIRGKLCRRIGIALGAIAFMTFWGAMIWIMQRKAHKYQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEY4</accession>
    <name>A0A1E3IEY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028688.1">
        <property type="nucleotide sequence ID" value="XM_019179332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEY4"/>
    <dbReference type="GeneID" id="30196540"/>
    <dbReference type="OrthoDB" id="2575404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="202" mass="22581" checksum="E359FAAB048161C1" modified="2017-01-18" version="1">MYHTVDDLALSPLDSGAQNRRSSFSSRPLTPSVFRPRSSPPASNHEIAAGLHYRLLTPASSPICSACANESDLGHDQVCRLCETWSIRRHDSINRVFQSYLSRVAGAVVSLEPSTQEGRRRNDLRVRGGGGGALRNADYDLKVYGLEDKHMYVVDGRGKPREMEWLDWVQGRIVAWLSKRDAEVVSKAPRICSAPLFFRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IF44</accession>
    <name>A0A1E3IF44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028912.1">
        <property type="nucleotide sequence ID" value="XM_019179154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IF44"/>
    <dbReference type="GeneID" id="30196351"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="586" mass="66064" checksum="FCDC1708AC7D33E6" modified="2017-01-18" version="1">MSLPGAALDPLLRLDPSITLEILYLLPLHDLISCQLVSKSWNTVIDSYSTSIYRNLSLSILYSKRYSRLKAAADAPETTRISSSDALVRGIKVDWKAAVKKAVMEEKNWKYGRATTKWLTPGSNAVWRQKIDPEEQVLYTVSRIGGIQAHTLAAPHTPLFEYVDTAPYGHLEFTKGYLIFNIENHYEVHLTPPALARLSPEKKGRIPNVEESATYGDGWSHTKKRPWQLQDGETLRGHLTYYRSISTPTDCFAFRARTDREGTDKERPVVGFAGATHAYIYGLANDGYVESYSFAGDIMNQDVNYIEFDDDFLFVCGDHDMRTFSRHTHKALSTFPEMSFEQPLHVFYSLFPNEEKTALPVRTPSGPVEKPARAELVWLDGWWIGDSDSENNRIQRQASLFDNDPLFNACHYTSRDLFCSNISGILYVLRSYREVLSIPDPAKRQEAITRHLLLLDVGGDLETGERGEEQMLNQLATCGEKVVFNTNGKVYVLDAASLPAPPYDPPTPSTPSAPCPQIRLLSLLDVHQHGLRHSSSLQMDDTTIYLVYWAQERVRNGGDEIDISGAHLTASDLGMCVKAWDFGWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJQ7</accession>
    <name>A0A1E3IJQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029395.1">
        <property type="nucleotide sequence ID" value="XM_019178694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJQ7"/>
    <dbReference type="GeneID" id="30195851"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70280" checksum="C226E040876761E7" modified="2017-01-18" version="1">MRNVLFKPGPIDSTKDTARSKKRRIKCDTQIPCKECTARGLAHLCRKETVIVKGRIVSDGDDKGDLDERLKVMSKEELWGQVQGLMKENEGLKMMGTGASGAKIHPSSENRSQSKHAPQNDDLSNMARRLGFLHESSCLSIDPPNIDNKIDDCVTFPSGLQLPSQETSYHLLSYVFTHLGWLLCPIPSSFQDQASFIFSPDSPSPFSHLHTAKSLAEARPSWSVLSFALISVALVYAPAELLEGLGIGVEQRTFFARLWFRAAVSTMLDGGSCLVNPSMIQLQTFCVLTLLFQPFDYMALHDTLLASMIQVARMLGLHLLKDSTMERTASSEIGRRVWAFLLAREVHYTGESYCPSVSREEQEPFASFLNISEPDTIPLIPLPLSHPTRVSYLLAGSRMTALTRDIKRLPPDADYAEVLKMDERIRDMNKDMEWLEKDDASHPAWVATARHVLFLKTCQRRLYLHRHYFSLTATHPQYAPSRLMSLQAASDICLERFLHDLPFDDKLDTINGVLPAAIVLLLDAIYPLKGERLTFGFVIQRCEEVERLLAPIRFSTYRSSTQTINITLKSVDRLLADTLQAAQAAEIVRASWTQLVLQPGGDTFGDLLDGLSFGSLLDSFEDMGPVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJR5</accession>
    <name>A0A1E3IJR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029316.1">
        <property type="nucleotide sequence ID" value="XM_019178615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJR5"/>
    <dbReference type="GeneID" id="30195772"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="17069" checksum="DAF315EDDC59271C" modified="2017-01-18" version="1">MIHEELSTDMDRITQLQDAILDLLTITSTSVEYITKRTQFEQTSKSIPTTLTTANAASREDYKAAISAFVADIIRRSKDIQQLIEELPKPGDSSQRAERLQHLQEEIKVANQEYKDVLEQSKQLVKELQLGLDTTLETTPSPPSSPRPLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA5</accession>
    <name>A0A1E3IMA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029631.1">
        <property type="nucleotide sequence ID" value="XM_019178475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA5"/>
    <dbReference type="GeneID" id="30195628"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017082">
        <property type="entry name" value="Ribosomal_mS29_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036996">
        <property type="entry name" value="RSM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN89722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="47321" checksum="46ADC3F04AD806BD" modified="2017-01-18" version="1">MSTRPIVRFAKTPLARGLTTSAPAFAPKKATAATAKAKQGFAKKKKADAPSSSGGKQTIALRYSMAGTPPDLSDLPRLQPGTFRKDTVGKATTLSKQSFDKLKAIGLPTKIDKELSSAGGPASVVREATLDVVKRVESAKNGNSKDSRFILTGEKGSGKSMLLVQSVVYALETDWIVLYQPRASKWTNSTSHYIYDPSTKTYSQWESAQDILNVLVETNKDKLDTIKLDKTVELAKGKEIKQGSSLTELAQLGAKDDRVAVAAFEAVIGVLEKQTRFPVLWAIDEAQSLFNTSKYRTAEYTPLEPYHLSTPRLVLDFIAGRRAFARGSILTSLSLSDPTNLPSPSLSTALSLPTTQPITPYTPINPYHLAHAHGLTPIVVPHGMSAEEAKGLFEIYTKKGWAVGASDELFVEGFVGTQGNPKEMGKGWEKTFMALTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA7</accession>
    <name>A0A1E3IMA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029643.1">
        <property type="nucleotide sequence ID" value="XM_019178487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA7"/>
    <dbReference type="GeneID" id="30195640"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN89734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="517" mass="57316" checksum="5BC297505AC93348" modified="2017-01-18" version="1">MSVMLETSLGDLIIDLEVEKCPRTCENFLKLCKLKYYNLNAFFNVTKNFIAQSGDPTATGAGGESLASLLHSQNPSGPAPPRYFSPEILNSLKHTHKGTLSMAVAPANPPGCGSQFFLTLADGIDYLDGKHAVFGHVIEGLDTLDKINEAFVDQESRPLQDIRIRHVEILEDPFPDPASLPSPPPSPIRPPDNLSRIADTEDVHKEVDEEETEELSRKTAAASSALTLEMIGDLPFAAVRPPENILFVCKLNPVTQDEDLELIFSRFGKILSCEVVRDKKSGDSLQYAFIEFDERSQAEQAYFKMQNVLVDDRRIWVDFSQSVSKMNRTMLSGGGVPRGGRGGGRGGGGGRGGSGGRGGGGGGYGGQRDNGYGGQRDSGYGSRGGHQDTSNSRRRSPSPPHRSSHRYRDSGRERDDDRPRPPVHTAGDIRGTEGYGMVFDAGVPSGSGSGSSSRRDRERERDRSPRRRDDRDREGDRRHRERDERSSRDGRDRSDRRDRDRARERSHRDRDDRDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INL6</accession>
    <name>A0A1E3INL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-D-glucosamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029716.1">
        <property type="nucleotide sequence ID" value="XM_019178278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INL6"/>
    <dbReference type="GeneID" id="30195424"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="57375" checksum="E2C095E408BAFDDA" modified="2017-01-18" version="1">MDLATRTPRPEMLPRLPTPPLSPARPQLILCADGGGSKVCVVVRSEDGLERRGYAGPSNVQSVGYQAASQNILLAAYRALSLLPSTHIPPSLEIPPVQDISCPSSGYVSPVPQAIAPAPVVPVSAPAPSAALPISLQANGKGLPTPPSSVSSALGEPNLAAAMNNTLAPPLPPPSFRPNGNGASTPRLLPPLNVPLFRSAWLGLAGISSKNDEDTFGRYIAGSLAMDAGRVKISNVDVNLLAAPALNFPGISHVLTLVAGTGSVGRTIRLSSPTAGQKQTLPLDDVAVAKGWGYLLCDEGSAYWLGRLSIRLLLSLSDRLSSSSIYSSPPPPLLPLHQDLLDYFGVTDPLELIGLVSLGGEVGSLGMGVGEAVGKRNALIAGAARIVFRYAFPHDEQVVKDRQDKDRTRKAAALAADRGMRGWEGEGDVDWSESERGSISSSSSMLSLSPDPESADSEETIHQSHLLALQLSRQSSLPLIQLALSLIGDQSIVRPSSSCLALGGGLMMSEGYRGMLLEGLEKEGVRVGKVVVVSDAAVEGARGLAKVQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INP8</accession>
    <name>A0A1E3INP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029752.1">
        <property type="nucleotide sequence ID" value="XM_019178314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INP8"/>
    <dbReference type="GeneID" id="30195460"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="11369" checksum="8B30047DD0DFB1DC" modified="2017-01-18" version="1">MPPTPTQHQRTPLRARSTNTPYGRSATVQQAADKSPTNLPSPSRPLANNRSGSLFKPPMPANICLPVDEPVAVVDSLEAAAGHLDALERSLDNLASSPPFPPGHSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INX4</accession>
    <name>A0A1E3INX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029535.1">
        <property type="nucleotide sequence ID" value="XM_019178379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INX4"/>
    <dbReference type="GeneID" id="30195525"/>
    <dbReference type="OrthoDB" id="2575066at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="911" mass="95107" checksum="D585E383145048F0" modified="2017-01-18" version="1">MASPTAYQKARLSLAMRGLDGLPLDEYLSHLPPLPDTPKNSPPIHHIPDGIVPKSVSQYSTPAPEVNKQNNGLLHPRGGQAASWKVPGSIRRARSPLAKEVTPAEEPIDAGETRPEGQGDTLDRSTSQQLSPLAPAQALPSNPPALNREPANPSPAPAPRLSASFRLPNMGDLSLIGDCSLFGGGGVDDDSLLDFEMSHIRPHGRDTPTSDPSSVSELRQGNRLQAPSAHLAQSTIFPSSPAHLLASTNALDRVDPPWKGNESTMSTVSSDDSSDTLNINSRPISPTKGSSAKTPLLPRSRGTPSSQFSSSLQSKSKRTFPASSSGNSLAAVGEEAEYRPEREKSTLLPFGLHNAAYPLRDEDLLSRETMVQDKSYRLGDLPTKQMSIPKGNLGDMTMDVKALMANVGKPKRASGTEESFVDLLNAEDEDMIDRMDMTMLGADETMMLPAELRPHVATRQAPPSRGLPTAQTSRGLAHLANKDPLSDAPSTLTRSKSLSKVAEIIQRVKADKAASALARPTTPPKTVSSARTYKSSVDSAVTPAVHKARTNVAPHTTGSRRISRSAGAMPMSESASQTTITLPSTRTPAHARTQSAAIPGSVRRMPTSASSSSLSSRTTGRSLGVTEARNARVKETPSSTLTARVPRESIMTAQKPRVGSTTSSVTTVASGARAPASTRSAVTLASTRSLPRSATTSSLSSTGLPTPRAPRARASIAPAGLPRPGTGSSARSAVASGVAATTPAPRARTSRAFGNDATATTNRATTTSDAPATEARSKLSTIPTSSAGAPTGATSASERLEARALSTPASAIARQTTLPSSRAAPSVEARKSTRPLVSASGQPPRPRVGSTLPRAPTSRVPAVGGKSSAPPTSSSSSLASKSGANLAGLRFRLDELQAKQQTRSKRLAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP66</accession>
    <name>A0A1E3IP66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_06243</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029747.1">
        <property type="nucleotide sequence ID" value="XM_019178309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP66"/>
    <dbReference type="GeneID" id="30195455"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN90225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="312" mass="33613" checksum="91A695221017D285" modified="2017-01-18" version="1">MADIKKPKDTKAFLTDFMMGGVSAAVSKTAAAPIERIKLLVQNQDEMIKQGRLATPYKGIGDCFARTYADEGLTSFWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKNEGYWKWFAGNIASGGAAGASSLLFVYSLDYARTRLANDAKSSKKGGERQFNGLVDVYKKTLASDGIAGLYRGFVPSVAGIIVYRGLYFGLYDSIKPVILVGPLEGNFAASFALGWAVTTSAGLASYPLDTIRRRMMMTSGGTVHYKSMFDAASQIVAKEGIKSLFKGAGANILRGVAGAGVLSLYDKAQELMFGKVYAGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ82</accession>
    <name>A0A1E3IQ82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition domain-containing protein (RRM)-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029844.1">
        <property type="nucleotide sequence ID" value="XM_019178125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ82"/>
    <dbReference type="GeneID" id="30195270"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001148">
        <property type="entry name" value="RNA recognition domain-containing protein (RRM)-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="24824" checksum="7D32F4D7AB8324CA" modified="2017-01-18" version="1">MSGQAADGYTEEQRAAAYYAQQGYTEPAAAAAPSSSYASYSTGPYPASASTSYGASYDADMLQQSSVYTPQGAAEAKHRAPGKRETVIRKGNGKVWEDHSLIDWDPKWFRLFVGDVSNDVNERTLDEAFEKYPSYCKCKVVRDRLSEKAKYGFIAFKDPEDFLKAWKEMDGKYVGNRPIRLMKVKDDKYGSIRTVEISGKKAKQLEKIKKNHGKVGNRPAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ91</accession>
    <name>A0A1E3IQ91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029810.1">
        <property type="nucleotide sequence ID" value="XM_019178091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ91"/>
    <dbReference type="GeneID" id="30195236"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14278">
        <property type="entry name" value="UBA_NAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="114" mass="12522" checksum="54C2521A722126A8" modified="2017-01-18" version="1">MSRVAQGEVIQDFLDGGNYIRDRLFKSLDSTKERWDTKEEGQKAQKALEALEVSKGANHVKAEDVDCISNQTGISKEDARAALIEEKGDLVKALLKSVQPRPRARSVDGGAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITR5</accession>
    <name>A0A1E3ITR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030157.1">
        <property type="nucleotide sequence ID" value="XM_019177773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITR5"/>
    <dbReference type="GeneID" id="30194907"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN92023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="27429" checksum="C191DE1D67EC9E11" modified="2017-01-18" version="1">MAQEAGLPITNTLFPPPPPYFQAFTEEALHRYRALTGDSSFLAPSASTSTVEQGSGIAKNEGGAIQVDSASVERMLDESEEDEKQELEGKLGRPRADWINEDGRWMCFGSMYTTVPKIPTAEDIGLPPFIDPSESPSESLPPLLHSFLHTLLMLLDALSMTARTPDELLASGWAHEGDQYMQHLTNLTANMMVASNQLRAAQSEATLVLLMEKELEERKKQTERLRWKCKEIAGGIKALKELRGAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUD1</accession>
    <name>A0A1E3IUD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029947.1">
        <property type="nucleotide sequence ID" value="XM_019177908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUD1"/>
    <dbReference type="GeneID" id="30195043"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12567" checksum="9089E8722AED8A9E" modified="2017-01-18" version="1">MLLQIYPSLLDAPADTARRKLIQEGGVYVSCLATTRVNRKEAQEKVDWELNRDLATRAKADGSRTAILVSGSHASPDSSFFYLRIRGQLEEHFATLGFDHVVILKPGMLLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVU2</accession>
    <name>A0A1E3IVU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030160.1">
        <property type="nucleotide sequence ID" value="XM_019177776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVU2"/>
    <dbReference type="GeneID" id="30194910"/>
    <dbReference type="OrthoDB" id="10459785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8759" checksum="D5ABAA796C3C81C2" modified="2017-01-18" version="1">MSNAQFYGQQQMQQYPPPGGDYYANQQGPPPMHNQYVPQQMDYNQGPPPQQQNDKGEGGGAGAGTAAACYIGHVSLESGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXN2</accession>
    <name>A0A1E3IXN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030498.1">
        <property type="nucleotide sequence ID" value="XM_019177345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXN2"/>
    <dbReference type="GeneID" id="30194468"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="10212" checksum="8AEECF1ADAAA13BE" modified="2017-01-18" version="1">MSAPQAPQAAPAPLAAPIPSEDQVARKFDNCVADLLVNAGLGFGVGVVASVLLFRRRGWPVALSTGFGAGVAYSNCNYSLNPYVLPGTKVLPSLPSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXV4</accession>
    <name>A0A1E3IXV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030507.1">
        <property type="nucleotide sequence ID" value="XM_019177354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXV4"/>
    <dbReference type="GeneID" id="30194479"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="380"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN93402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="954" mass="106166" checksum="310FA53B17B8D9D1" modified="2017-01-18" version="1">MPGSNSQPSRSRPAPRMNPLWYTYASATLLAAAVLGNILRWSFLEWQDPYHCSAMLNTGKWLDPGTYTNWQPEGCFQQPLSAQSWQQCLASSALYTQSSLRDSYSEKRTALFVGDSTVRQLYFAAARKIGKTSKAWESEGEKHTDRTLLVADPSGGPSLELDFWWDPYLNSTKTTSLIGSGHTDPTSLLVMGSGLWYLRNPSSGGLAAWGGMIHDTFEHLKLNQGSPRTALLNPWDDKLLGSGVTLPGLLPNPKVADHGRDFERDVDARAFPPSSSGASDFSISDAIVVLPIPIPVQARLSASRAESIFHTDVEAMNADLYARLTHPDPPPIIIPSVFNQLLVDEETEDGLHFSDRIMNKQAELLLGWRCNDVMRDEGATGTCCKRYDWVTPIQGLILVIMVLYAPLSILLAPRLHPKSPIHNYLPSANTAPALSTFGLAMGYLFLADRTHVFQKEQKDFDAWVFGVITLIALIVGLGTLKNSGKDLGFLNRDITDEWKGWMQIAILIYHFFGASKISGIYNPIRVLVASYLFMTGYGHFFFYYKKANFGFQRVAMVLVRLNLLSVVLPYTMNTDYVFYYFAPLVSWWYMIIYTTMSIGSKYNERPAFLLSKLFACAGAVTLFMHYTSLMGSVFQVLNAVFKIEWSAKEWSFRVTLDLFIVWAGMLCAYAYIKFKEYQLADRPWFNNARAGVLAGSALSMVWYFWFELHLANKFVYNGYHPVVCVVPILAFVFLRNASPTLRSCTSTVFCFIGQCSLETFILQFHGWLASDTKAILLVVPTTKWRPVNLVVSTVCFIWLSYRVSGATGEITEWLIGKKKSLPPPATASGPGPSSGQAGPSTATEAVEAIVEGPIDGAKGGVPESIPMMNHPKGESGDRGEQVLESRRESWPHWMAATAASLSNRTAEGYAPSDRAWKDQTVLSVARNIGDLAQRHTSVKLGLVILGLWVLNWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY36</accession>
    <name>A0A1E3IY36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030635.1">
        <property type="nucleotide sequence ID" value="XM_019177482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY36"/>
    <dbReference type="GeneID" id="30194608"/>
    <dbReference type="OrthoDB" id="10287233at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="481" mass="54312" checksum="9D341D0CB479CDB1" modified="2017-01-18" version="1">MASFRRLSLRPAGDDAVVPSTPPLLEKKRRHSSFFAKAAASSPKSYLSPKDDTPPASHHQIIAPSPKTARSFRRTAVKTPDLCYHVVRQVISHFAEDSTLAERTVLLLLNKEIRSIYLPFTYQRLSLDPTFCRQFFCPLFRAVKLDSILLFAHTGNTFGRLTPSDVPLVYPYPPAPATSPTALSKLKARWSSLIVVFVPTPTQQELRTRRLGGRYRCLLMNTEVLVVHDVMSLKCLAAFLLAVLQDLLAIDLQEHVPLSPDFRLLPAIRWVVYTADFAADIDITRPTLPAECALHLASRCLFSTHRCVHSSPGNNNIFASKDLLLFPATGKRFVPTVKHLVLHNVLPREVKHCYVVPHIEMYLSKLQDAWWEEGGVYGRTKWDNREEAEVAWHEVSIKDWLVRFFCGGAEGFELEGPMKRYLPAVELIEFNNTNADIQKVTQDTYEHLYSKGMVENMLAWKGVIKTSKPGWKCCEGCGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY95</accession>
    <name>A0A1E3IY95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030685.1">
        <property type="nucleotide sequence ID" value="XM_019177532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY95"/>
    <dbReference type="GeneID" id="30194662"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130099" evidence="13">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="38"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN93580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="27828" checksum="8D6ED88B2909B2DA" modified="2017-01-18" version="1">MQFLTSLSALAFLSTALANPIVGKRSWPDVIDNCNQDGTVALTYDDGPWDYEEDVANALDGGKATFFFNGNNYECIYDRADQIKALYDAGHTLGSHTWSHADVTELSWDEFHDELWKIEEAFIKILGVKPKYFRPPYGNINDNAMNVLENRGYSKVFMWSDDTEDSLDKGAARGEEVLDGVANDYPNPHLVLSHSTYPQNSQEVLPHSLPKLKSAGYNLVTAGQCVGTDEWPYEWVGEPQARDDSWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0F7</accession>
    <name>A0A1E3J0F7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030898.1">
        <property type="nucleotide sequence ID" value="XM_019177317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0F7"/>
    <dbReference type="GeneID" id="30194439"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000652">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000944">
        <property type="entry name" value="Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="443" mass="48258" checksum="D88531FE13C54985" modified="2017-01-18" version="1">MSLSPPTHESYLVVGGCGFLGRHIVEQLLARGESQVSVFDIVQRHFDSNVTFFIGDLSKPEDVENALIKSQATVIIDTASPTHGLGRAIYELVNITGTRTLLDAALSPSSLVTKIVYTSSGGVIYSGKEDICNADERISYPVKPLDAYNETKVAAEKMVLQANGQEKAGGGLLSTCAIRPAGIFGPGDRQMISGFYGVVKNGQTKWQIGDNTNLGDFTYVGNVAHAHLLAADKLTTVYPYSALREPLAPINLSLGSHRVPTSAAKPIGPNTNPSKADLLAAERFEQGLIEESDLRPVLRNKMDVYYDAASLEDIEHPEAGLPIAGQAYFITNGEPIFFWDFARTIWRQLGHVPPYTIVLATALGLILATLAEAFSKLSGKEPGFTRFRVSQATQQRFYDIEKARRLLGYSPVVGLDEGMKTWTTWYRGELDKQALAGETDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J216</accession>
    <name>A0A1E3J216_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030697.1">
        <property type="nucleotide sequence ID" value="XM_019177116.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194230"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="889"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1484" mass="157694" checksum="335BE5CA59F50941" modified="2017-01-18" version="1">MTPGPLNTTDNQTGTTSAWARGPPNKAPSAPNNAPSGTSTPSHPAPVLPSHGPSAIPIGGGGHSRKNSLLVAGNGEFKKGNLAFGTVDSPTAALSSSPAAPSMTGGHLSDAVRSFGSIDAADKQDGPDAISSRRSSVLGNAAAGPSQGKKLGIHALFSSKAPQPHTAPQPQPVMSPPQHHHPPAPIHHNRRQSFGHNGGAFQQPMAGSPNQHFVGSPHMRPPGAHPRSPVPNHNMPFNPSAPQQIQHGFRPPQQPQIRPNNMPRGGPGQYGMHSGPQGLPYPIMGFPQGNFYPGAYNPYEQHQQQQNFGGPPSQWVPQQSQSPQQHFGSGYPPSAPGPVSPRAQSQMLSPPTQSPLPPPPAVANEGTSPVPTPPMRPPSLMSSHHHSLSNASVASIPHQSTGSTVGGPSTYLSGNATNFAPRKSAAVKISRPDGTALDLENIKEAAKPAEAASSTNPVSASTTPGSEVLKKRALPTVVRIESEEQRQKRMAEEARAKELKNADDIAEKERKERMERKAKDEQEKKDKEAKDKSDKDASEKAAADAKKAEDEKKRFEAALAAQAAAAKKVEEEKAAAVKAALEKSEKAEEEKAKAHAATLEARSKAEEQLRAIVETPSTSVTPSPMGSPALGAGLPAKPVAALGAAKRTPPSALNLATASESPAPLTASASALTSARPIDDITSVNYPHALLSPSIDLNKNAEPGKFRYDRGFLMQFMNVCREKPESLPPLEDLGLDVDGASGFGGRGGSSRGSRSSMGPSSRVPGGAGATGLGVTGARSSYPNSFGTGQFGSGPGSLRGSTSESRYHASLGPRAPSGRGAPGGIGSFSGLPSMGITNSRNGASRGSQRGSKRVPSQAMAPPAPAIPISENAWTRTRLGTNDESSPAFIERKVKALLNKLTEEKFDPISKQILEWANKSANEEDHMTLKLVIKLIFEKATDEAHWSAMYAKLCRLIHDQLDQAVTETTADNKVYSGRALFRRYLLGRCQQDFQSGWKAREDTAVAAAAKEKEDGAKVAEKEMEKKPEGGEEKEAVLLSDEYYAAQKAKRRGLGLVQLIGEMYKLDILTYRVITECLTKLLANFEKPDEEDVESACKLLTTVGDKLVKANPDLLDGSFTALEKILKNDDLPSRIRFMIMDVQDLRRDGFRSQKNQSSVMTIAEIHKQAAKEKNAASARESMSRGGSRAGGRRDPPQQPGDWQAVPGGPRVAGRPVDFAGIGRGLSSSARTSSPSFAGPTSVFSRKGGNTASPAPPVSRSTSSNMFSALTDGQDNTGSSASRRDSADAGEPTPQRKRLSLAPRTKPVPTEGDEEEDPQDGEGGESGESEEDLSEEQAKEKINLDMKELWGEKDQGGSRNPGDVVEYFTSLPQNLRHLLAARLLEDVFRLSKPRDAEVVAKGWKAALEAQAVPVAVFKETLEERVVSLDDDAVDFPGAYKAVGELIRSLSLADEEIQNLISKIEVYGQPRVTPQQKLEKALKEIDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J240</accession>
    <name>A0A1E3J240_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030717.1">
        <property type="nucleotide sequence ID" value="XM_019177136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J240"/>
    <dbReference type="GeneID" id="30194250"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin-like" evidence="1">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="21595" checksum="E4FC43E435D3B4B3" modified="2017-01-18" version="1">MTISHIAIPTACSVSAFTPASLQKHLSTTPILPLHLPNIADAWPALASWSLKDNLRILRDRIGEERVAEIELGKSGRGYLDQEWQKINMPFGRKIFHVVPPAASPHLNPSPKPLHANTSQIPIPVSRIVSPFSESADLDDLPPNTLAECRDRLRRAYELEGGCQVVVGPGESVLIPEGWWHAAEGINGPGVGVGAWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2G1</accession>
    <name>A0A1E3J2G1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030837.1">
        <property type="nucleotide sequence ID" value="XM_019177256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2G1"/>
    <dbReference type="GeneID" id="30194375"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="112" mass="12129" checksum="CBEBAA0C5A502BE6" modified="2017-01-18" version="1">MVVAAPVFDKSEPKADKLFPYHLPNSPEWDEYNDWYSQTAMTSAAAGMFIKQPLIVWGAFALAVFGYVNQQPLRQAKDATSPILVLGMALAGVFGSVLPKMMLAPAPAQTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2P2</accession>
    <name>A0A1E3J2P2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anon-23da protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030752.1">
        <property type="nucleotide sequence ID" value="XM_019177171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2P2"/>
    <dbReference type="GeneID" id="30194288"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="489" mass="53475" checksum="04B932D7BA963F4D" modified="2017-01-18" version="1">MDLSPLTPRPLTSPTHHLNVATICSLILILYAAYYILVRRYASITIIGPLCRAEVGENRETTEELVRSWCGSLKQGFRASWWLPIGHAQTIYSALADFSKDDQLVYQRQLLRLPDGGTIGVDVYPKLCVKLPNSAPVVIVNHGLTGGAHESYIRNLVLCLAKPMKDGGLGARCAVVNFRGCANTPLTSPVLYSSGNTIDNHTATLYLASLFPDAPLVGIGFSLGAAVMTRYMGEQGAKSRLRAAVVLCCPLEFRSVTAKLDSAHIFPRLYSLSMARKILSSIYPHLLPHSALSGPSSELHSSIPEILSLTASFKYKWTLRASKVMELVVTKVGGSGPCFPFEGMDSFMEWACPSGWLGKIKRPTLAISALDDPIVSGDCLPFSAIRSSSHMVLAGVPQGGHLGWFDGPLFGPERHRRWHVRPIIEFLRGVIQTLPKSASEKALPVIKVVEKENGWCWVRDVGWRVLDEDEDVGWAGSRGYDEGTVHVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Z1</accession>
    <name>A0A1E3J2Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031199.1">
        <property type="nucleotide sequence ID" value="XM_019176724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Z1"/>
    <dbReference type="GeneID" id="30193820"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15368" checksum="3DC62502C3A95ED1" modified="2017-01-18" version="1">MPPKQGDDDVSLPKATVLKIIQELLPDEISASKEAKDVIFDCCTEWIKLISTQSNMVCEASSKKTISPEHVVEALKQLGFEDFVEQVEVSNADFKQAQKERVRSQPDTKGMTEDELLELQERLFASSHARFGGNGNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J0</accession>
    <name>A0A1E3J4J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031434.1">
        <property type="nucleotide sequence ID" value="XM_019176506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J0"/>
    <dbReference type="GeneID" id="30193600"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="64" mass="7352" checksum="2B5F5593632DBCFC" modified="2017-01-18" version="1">MHLMYTSDEKGNRIYTLKKVTAANKPTKSAHPARFSPDDKFSRHRVTIKKRFGILPTQLPSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4K4</accession>
    <name>A0A1E3J4K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031438.1">
        <property type="nucleotide sequence ID" value="XM_019176510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4K4"/>
    <dbReference type="GeneID" id="30193604"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13512" checksum="1633DA85200F8CD2" modified="2017-01-18" version="1">MAQGIPDIERPWYRKGQYCFSMVSLFCYIVIYLTNGFAVFLKGNWSTSNFIFAYASLLFFLVPWVGYKIVRRGWLTPLEEVDLYAGRTKEQLDSNDDVEMEPVTKGQKFNKWLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4M5</accession>
    <name>A0A1E3J4M5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BUB protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031483.1">
        <property type="nucleotide sequence ID" value="XM_019176555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193649"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="963"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1291" mass="142084" checksum="FAE78D02BFB62939" modified="2017-01-18" version="1">MASPPRSPTGAPTTDFALIEAQKENIRPLATGRSAATLSAVLKEPSAAEKVVQEGHDKHRQAIEEAEKKDKAGQDQDDDLALLGDILDVYNKYILFTVQHHPSSDFHLLPLLETTTRRFVNDARYKMDPRYLRLWVMYARHIERREEIWAFLESRNIGTDFSLFYEEWATALEGLGRRKKADEVYRIGIARKANPVERLKTRHKQFLERIMAPPSGVVPDDDPVSASSARTPSRAVLGQVRSGPSSSVAGATQLAPSMRTSSVNNGRKMEIFADAEGNKDETSAPEWADFGTRDERRKENTAEAGPWQGETLPQSANRGRVAPRTPKVAVFQDTTEQESARVQGASEVFSRHRQPPTEAELLKSDPLRHYDTSSLSTDLPSLPAPPSARKPPRPTKVAAPAAGAAPAPAKAAQAKYVMQPWTCPTDGPLVKMANGKQERRMFDWDMVYKDGDEYNFEQIRAKQRGLYGREGRGEVQAWEREMHKPGSTSPPKSKSVESRKPPSPTVNTKLAEAEVMSMFDQTIHGGKMNRDSDSESESESESEEDGGVQIAPTPLPNRTGNVQMLAPTPGGFVPPTPTPSAPSRLFSAPSSLPTISDENGKPSKPVVFSDENDRPTVFSDENNVPPPSAKKFNIFSDDASAPPPSASKPRAFGVFSDENQTPARPPAASQETPRQPLAASNIFSATPAVAPPNHGLGRVTEAIVEEEEEEQVAPPPQTEDVVEDVVEDVVEGVASASLDEPPAESNYYDEEEGQQPRGMRRFNINMMTPITERTCEYTQFTGASGVGRESLARRLEEEEEDEENEETGDKGDSAAPSEFDESGLASGDVRDDFQLPDGFTIHQAEERSDIHTMVLVDGKDEGTATTLQDKSVYHTANGDQIGASELADPCDPTAESTVTALLNAIDPPLSELPGLVDNRSTAINKLDALEKHARSKLRRASASSRTSTSGDDSCTLTLAGNDFEVHDKLGQGGFGIVFLGVDIALRRAQDDADSDDEEDEPVDRSQVAIKVEKPGMIWEAVVLDRIHSRLDKALRQSIIQPRNLYLFRDESYLILDYCPQGTLLDVVNKSSSIFGNPGQGVDELLAIFFVIELLRLVEGLHSAQFIHGDLKIDNCLVRVADLPNSSWSAAYSRAGSDGWSQQGLRLIDFGRAIDLSLFPRGTEQTFQVSHTVDDKDCTEMRQGKSWSYQTDYFGLAGVAYCMLFGKYMKTMISEGKVKIDQPLKRYWQPQLWQPLFDTLLNPGHSLPITSQLTTIREELEGWLEDNCQKGGKSLKSLLRKIELAATTGKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q4</accession>
    <name>A0A1E3J4Q4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031488.1">
        <property type="nucleotide sequence ID" value="XM_019176560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q4"/>
    <dbReference type="GeneID" id="30193654"/>
    <dbReference type="OrthoDB" id="2571264at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="104" mass="11250" checksum="A485AD9FF4AE3A61" modified="2017-01-18" version="1">MSGLSTQNLVNDIALLRTISPSSLPLAKAQSPTTSNTPRQTLEAFAPSKATPEDSQRLAKAYVKEMKRVNETQGKGEGEEVGERIDQLRALGEDIQKVLGDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5F6</accession>
    <name>A0A1E3J5F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031161.1">
        <property type="nucleotide sequence ID" value="XM_019176686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5F6"/>
    <dbReference type="GeneID" id="30193781"/>
    <dbReference type="OrthoDB" id="10376151at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="307" mass="34646" checksum="68AC6024F1AD67A6" modified="2017-01-18" version="1">MANQRRVASSLPTPISSDQSSIVVDQTSNANARPSSVTYTSLPVETSAPLALIHRSHTIDTCRSVYFRDLEEFYEAEVQWASQLQANKDALPQELSPNRLLRFTSSLIVKQGYLWNIKGAQLCLHLPFELSSDEVSQLWKLPSLVNKMFSETYPLALTMHNARSDLKAWVDSGNGGRTVIMDLAPEMARSILDFDTRFIDEYKYVLCGRHSSNYAHIPSLKFMNFGTTYHPKTDTLSSPSANKSDFMLKNLKNEHKHLANELQQAEEWHNPDPLAVYSSFNESANAEGEEGARSRGFVDEFRFCVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6C4</accession>
    <name>A0A1E3J6C4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-type H+-transporting ATPase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031638.1">
        <property type="nucleotide sequence ID" value="XM_019176228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6C4"/>
    <dbReference type="GeneID" id="30193319"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN96392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="12919" checksum="7A8F01AE75D033B0" modified="2017-01-18" version="1">MASILRLSAQKAPLAFSRSFSVSAAKKDLVQDLYVNQLKSYKPAAKSSDAHVGAVRSFTAPKAPTAPSLPTDLASELSKFDAEEPALGATAKKASNTSEASEGVEEYLAFLEKDLPKAEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6J8</accession>
    <name>A0A1E3J6J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031739.1">
        <property type="nucleotide sequence ID" value="XM_019176329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6J8"/>
    <dbReference type="GeneID" id="30193420"/>
    <dbReference type="OrthoDB" id="2574884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="793" mass="85478" checksum="E63E211059844D35" modified="2017-01-18" version="1">MAQLNEAVTRLRNQAREVAAQRGGGTGTPGVREGARVDDQGSRTGNVTIQLTEPPPFVLPSHIQSFISQHSLPPLTPGPQPSSDPEAWEVRAQTVENRIQRLSQAARVLRDRAQAQGERRQRMIDRPLRSDRPPQSNDSLAPWRRATDAADAQVQRLLEPSDHFLRRRDRETMVDGIRDMEGLNSNIGSELEGIAGQIHGLLLGNASGAGSETATGRCQRRASRSHIRRHENQQPLRSSRSRGCAPTNTRQVSRQPPPQVICTPHTAVAEPAPDITPELTPASQPTPVPAMGNTAAFLGHPAPAQARPSSRTPHFNLPSLREALGLEEHSPWAFGSEPDPEDDEGTVRGTPPPGGRVRIEQLEESIHRIENSAETSGGTYRSLVNGTLRPSSRPDGAAIEESGSSLSPQSNGREGAGSGTLRGVAARLRESADRQTAISRTPGLDAARAQTASLQPFPGANPPNERMEVAVELGPVVFIGDGDREGDWSDDSLDDLFEGLDPTAAFGDIGDVLAAGSPGGESGHNGGRSERTAQQEGMTFRGRRVADRIAASSAPSPAPSTPFSDPIVRHLPRWDYPADDYPWFRPRRPRSFRSGDTLSSDVRPIAREALGPNFLGGPVGRWRLAPLQNTREEDSATTGLTEGPSPVTPSRGTTLGPASSAGTSSAPNSTRHEEMMARIRHAREALRNIRGLREDMGTQRRGPPVPMPEVMHRESAVRQVREEAVAPHARSEGIQPVRGEITSEPDGEASAEVSTAQQGSSSTQAGSSRSAYMVCDREDSDFGIQQWPTFDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6L9</accession>
    <name>A0A1E3J6L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031753.1">
        <property type="nucleotide sequence ID" value="XM_019176343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6L9"/>
    <dbReference type="GeneID" id="30193434"/>
    <dbReference type="OrthoDB" id="2572173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="339" mass="35982" checksum="0A30531526B09628" modified="2017-01-18" version="1">MRLSCWNCTTLDGEDSKPAFGRDVRSAAPSPSQSPPTLPGLPRVKIIPATPISGLDDIPHPEPAPDTASSVITPPTVPTASSRVSLSGRRPPFIRSASASQSANPNPSLTSFFRSHSDMPPTRASGGTVMPSNMPRLARTPEQSTTGRPRSTFTQRLSGFFETYKPKYLQGSHNPHGTAEEVGATQTGAGTVYLPSPHRDLPDDPFASRIDMADGGDLGPLCLLPRDSEDSRYTGSEVGRDIKSERESGPGEATVDVQASLRTMSAPSSSPTARPYPFLVTTKVTQPADDDSATAMPKTSRDHHFPGFAKQSKASGRVEMMEKNLGQGVDMRGSAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N4</accession>
    <name>A0A1E3J6N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031775.1">
        <property type="nucleotide sequence ID" value="XM_019176365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N4"/>
    <dbReference type="GeneID" id="30193457"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="414"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="461"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="583"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="638"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
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        </location>
    </feature>
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        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
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        <location>
            <begin position="1083"/>
            <end position="1099"/>
        </location>
    </feature>
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        <location>
            <begin position="1257"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1268" mass="137079" checksum="F0F9FAA623553221" modified="2017-01-18" version="1">MSSKPPHNAKSANKKKPLPIDYSTQITTQLAGLSAPLNLTNDDLIYTANELYKRMMSDPEYGSDDAYWSSLPPHLRQFIRDAVPCAGTISANNPGNTSTQKTMYQMAQQIVQAASQGMGLGQMNGSARPPSLSLPQQSLGEELGFHRHPDSRSVEEEIDEDEEIEDDVDVPALNGDAPKKKNKKKKKKAGIQQLDVPAELPPPPPQTALPKAPPRPTPQPPQPPALNPPPPPHNANPHPAHHASSVAPTPPPSSRAAGKQPMSSAPPANPPARSARAAGKAPATAAPPHNHNHNHPHTHPPASKTPSSAVAKGKAPAAQPPAKIWTQSSAEDRENIRQFWLGLTEAERRDLLRIEKDAVLRKMKEQHRHSCGCAVCGRKKINIEMELDQLYEQYYDELRSYAAEQRTASNGLRAPPSGAGPFPGSVEVDASGTVTQYDHRAPDSGHHHDEHDHDHDHDHEELEDEESEEYDEDDEYADEDELDDDDIGTDEADVGDDDEEPPAPPPVSHRPTPRRPPSVKAPREENENDFLSFGNSLATIKGGILTIADDMLKNDGTKFLEMMEQLAIRRSVREEQNLRDMQEETDEEEDEAEPMTEGQRAEEGKRMFQIFAARMFEQRVLQAYRERVAKQREEQLLRELEEEEDSKKAKEEKKQKEAQKKKDKKKAQKQRADEERLAREAQLDEEKRLAKLAKEEANRERVRKQEEERIRREAVKRAAQEEAAKQALERKRRQQEEKQREEEAARKKQEREEKAKKEREAREKELKEKDRKDREAKSAKEKADKETKEKAAAEKAERERSAREAKDKADKERKAKLEAERAEKARKEEAARKERERATKEKAASEKAAAERAAAAARASQAAPVSYGARSPIKGPTPQPTPPISQPSPVKPSSSAISASSSTTPARSTQKSPPYYPQPLPPVGLPSGAFPRMGALPSYGGPPGLRQGYPAQSSATFSPPRTNGSALSPNSGTRGFPSTEPGSSFDQSMRTAPLGVGFPPVKQAGRMPAVEDAFAPSSSIGVPPSRSMSNAGEIGSMISTSSLHAEEYRASPTPIAPLAPIGRPAFSDMRAPPGPSAAPGAPPSTVAGPSGSSALRSRSPPLPDQVFGSAALGADDEIVQPQQRRPTATWDMPSAPGVGRWSSSPSIWGSAPGVGAEPSHNHAHAAATGSWGAPGIAAIGDRSAPPPGLSLSPTIGGGVLGNGQRQPSFGGIGSPFVAGPGAGVLGGGIGGMGGMAPGGSAGYGQGLFSPIQGQQHPHGHQPGHHQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8N8</accession>
    <name>A0A1E3J8N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031692.1">
        <property type="nucleotide sequence ID" value="XM_019176282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8N8"/>
    <dbReference type="GeneID" id="30193373"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11545" checksum="52A43D0DDC11AC73" modified="2017-01-18" version="1">MTIGILRQFHAANCAGHNLDEKQPCDDSTPPTNMAAIYRYTQRLAHESPVIFWSLLLGFAGPVAVLTVPPIRRSFGYQSPAPIPTSFPTPSRPRHIVKGYEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JB76</accession>
    <name>A0A1E3JB76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">L198_03929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031968.1">
        <property type="nucleotide sequence ID" value="XM_019176055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JB76"/>
    <dbReference type="GeneID" id="30193142"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="90"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="805" mass="88925" checksum="F0D8F3968CFC66C3" modified="2017-01-18" version="1">MTGVARAAARIRHVHAAPLYRPLILHRQPVLNALGAIQGKPLTRVARQGQSVAFPRRWASTAARTVDGGDQQWPERKLPVLSETDKSRLKRQRNVGISAHIDSGKTTLTERVLYYTGRIRDIHEVRGRDAVGAKMDSMELEREKGITIQSAATFCDWVAPTPPTELVDGQQFDNVGKENFAINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRLTFINKMDRAGSNPWRVITQLRAKLKMNAAAVQVPIGSEGDFGGVVDLVRMKAIYNEGVKGNQIVESDEIPESVRELVAEKRAELIELLSEADETLCDLFLDEVPISNTDIAQAIQRATTSLRFTPVFMGSAIKNTGVQPLLDGVCTYLPNPSEVDNQAMDATLPAHAPTIPIVPAADAPLVGLAFKLEEGKYGQLTYMRVYQGVLKRGTLIYNARTGKRVKVPRLVRMHSDEMEDVESVGAGEICAMFGVECSSGDTFNDGTSTYTMTSMFVPEPVISLSIRPEGNETPNFSRALNRFQKEDPTFRVHVDSESQETIISGMGELHLDIYVERMKREYNVACVTGKPRVAFRETITEPSKFNYTHKKQSGGSGQFGRVIGSIEPMEVDPDTGKDTAFDNRIIGGNIPNQFIPAIEKGFQEALDRGLITGHPITGCRFILEDGSAHAVDSNELAFRLASIGAFREAFQKAKPVVLEPVMTVEIVAPIEFQGNVIGAINQRKGTIVDTEIRDDEFTLSAEVALNDMFGYSSQLRGMTQGKGEFSMEYKNHQPVMPNVQREMSEAFRTKQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBK8</accession>
    <name>A0A1E3JBK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032101.1">
        <property type="nucleotide sequence ID" value="XM_019175611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBK8"/>
    <dbReference type="GeneID" id="30192694"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044590">
        <property type="entry name" value="CML48/49/50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824:SF2">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="355" mass="40076" checksum="6E2CFE0823D82E88" modified="2017-01-18" version="1">MASKMTAPSPYGSVSDEARRRYEERYARKRAEEAAKARAEAEAANTPPPHQQPPPQAHVHQGYPQQLYQQQPPQGYRAPQNYQPAPQQQQQQQQQQQYAAPVQQQHQQRPPPQQQYHSPPQQSHPPPSQQYHQQPAQNHQQRPVQGGYQSPPQQQQQQAYQSRAPVHQQQQWNGASQGQGLGVGSQQQGGYQQQEARAAPVAPAGEEDAELRSLFAQFDSSRSGQLHAFDLQRLLAKDATMEAREDAVKMDWHGIFCRFDRDNSGLIDRKELHSALLGFGFSLPPELVAKLEKRFAPPPAPGQTYQPGISFDRFLLACVTVKHYTEAFRRHDPGNTGEITVTYNDYMDIVLESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBQ2</accession>
    <name>A0A1E3JBQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031943.1">
        <property type="nucleotide sequence ID" value="XM_019176030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBQ2"/>
    <dbReference type="GeneID" id="30193117"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="575" mass="63700" checksum="A177EAA05D1E9DD7" modified="2017-01-18" version="1">MPLPSLFGALFPAFHLHSWAHIALSLLALIAATLFAAYLYAYPIRLARLHFYNLPAGPEPESFLWGSLPTLLKSEPNVPQGEWTAKYGHTIRYRMQLGAPRFMTLDATGLNYILSHPDVFPKPDVTRRALADMLGNGLLTSEGEDHKRQRRALNPSFSVGAIKNMVPTFYDKAYELQAKLLALVENDDPSEKASPTPAKEEDFVPGGKKIDVMRYLGKTTLDVIGVTGFGYDFKTLSEPNNALSDAYAQMFTAGMNITFKDFVLNRIPLIRHIPTEKSRIIASSRKITRDMGAKLVKDKKEVVMASFGDDLEKGQDIGKDLLSILIKANMAADLKPEQRLTDEEVLNQITTFMLAGNETTSTGLSWTLYNLALNMDVQAKLREEVMSIPDERPDLETLNSLTYMDAVLREALRLCPPAPGTIRQAKEDVVIPLGVPLKGRDGTMMESVGINKGTMVFIPIANVNCSEAIWGPNASKFDPSRFLSSSTEVKPTHVPGVWGNLLTFLGGTRNCIGYKFALAEMKAILSVLMKNFEFQELKSKPEVEKRSAVVMRCRIKGEEDAGLQMPLMVVPLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBT0</accession>
    <name>A0A1E3JBT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032171.1">
        <property type="nucleotide sequence ID" value="XM_019175681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBT0"/>
    <dbReference type="GeneID" id="30192766"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="321"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="480"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="571"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="696" mass="73695" checksum="12C4E0D93F37F4C4" modified="2017-01-18" version="1">MLPANTDTHLPVPIPVAAASSSQIPPDISISPGGQSFNTPAAYLPTNLWSSAGSPTYSQILSSSLGASSESDPDIMKRPLDNAMQPLLETGPAAPLDNFSKKPRYDGSIDAPGPNRFAAPTATPMQGQFNPHQMGHQQQGNFGQASPAMGMSMLQQQGGAQGNGAPFGGMGMGLGGFGMGFPFGMANMGMQNNFQGPIVSPSMNPNTMTGNYGPAAAAAAAAAAGNSTGRTVYVGNLPAEASVDELLNLVRFGPIENVRLLPEKSCVFISFLDGSTAAAFHADACVKKLALHGQELKIGWGKPSVVHANVAAAVAQSQATRNVFVGNLDPETNEQDLRNELSRFGPIDQVKIVRDKNIGFIHFLSIGTAIKVVTTLPTEPDWEGKRVNYGKDRCAYVPKAQQDAVRQAQTQAMNAIAAQHQQATGSPFPPFSPMSAGFNSFPTPNSAAGGAFPSPVFPGGGAGFSPVTPGFGDASQVGNRTVYLGNIAPDVTVEELCNHVRGGMLQHVRYFPDKHIAFITFVDPSAAMQFYQNAHASNLTIQQRRLKIGWGKPSGPVPPALLQAIQAGASRNVYIGQIADFELFNDEKLRQDFGEFGDIDMINFLVDKGVGFVNFTSIQSAQKAIEGIKLKPEYSTLRISFGKDRCANLPRTNMPNRGPAPFTPKKADTPMPAVQPEDGALEANIYDDGDAVLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBW5</accession>
    <name>A0A1E3JBW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RP/EB family microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032211.1">
        <property type="nucleotide sequence ID" value="XM_019175721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBW5"/>
    <dbReference type="GeneID" id="30192806"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="160"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="255" mass="28585" checksum="252291A7EC109BD0" modified="2017-01-18" version="1">MSVYVGESRGELLAWLNDLLAPTVVTKLEQCGTGSVYCQITDSIYGDLPMSRVKYNARMEYEYLDNFKILQKAFVRHKIEKPIPVDKLIKCKMQDNLEFLQWMKKYWDLHSRGEGYDAQGRAGGIIPSTSTATRPSAAAARTGVRTAHVASVPGSRSTSTSAASNAQVAAMQARVAEIEAHSESLLKERDFYFDKLRNIELILQDRLAVEGVSQEETDVMTKIQDILYATIEGFEVPDDEFLEGEEGLEPEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC90</accession>
    <name>A0A1E3JC90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032352.1">
        <property type="nucleotide sequence ID" value="XM_019175862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC90"/>
    <dbReference type="GeneID" id="30192948"/>
    <dbReference type="OrthoDB" id="2574101at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130239" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20384" checksum="08190C3ED5E90327" modified="2017-01-18" version="1">MLATLLPAVLLLAAQSVAARTCYNGYGRPYHCSGLSYGARIGIGIGIAAGVLLLFSLCGFWRRRQLRSQFSKYRPPALPFNGQQQAPQGQNPYQNNPPPPTWNNNAPAPPPATYQRGSAGAYGASTTGAEGHEHGYEWEQARQQEEEERRNKTSGTNEPAPPGYDIATSTQNTGNAGTTTYAPPAGPPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCB9</accession>
    <name>A0A1E3JCB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032382.1">
        <property type="nucleotide sequence ID" value="XM_019175892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCB9"/>
    <dbReference type="GeneID" id="30192979"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="552" mass="59252" checksum="3D3A028E251BD31C" modified="2017-01-18" version="1">MRSLFRPFPGPLTSRQWFYLSFLQGVGAGIIDGGANFGIAYAMYHGQDEIKMWVLAKNTIAGDLGVTPIIQCLASMLITSTLVHTDLHHHAVAPLPYVWPHVEHLPDPRRLIDKMFNKSSRDGVEKEDTENRETPSPDSEEEEGRKGWAYYPKMLTRFIFEGTEANILLSPFSWKLFFIKAFLTAAQGAALGIVLGFPVWCLFIIVLGPLYGTDNMAAPHHWKWAPMVIKSVYGAVIGWITNPVIAALALGSQAERHLLVVQHDQEASIGGDGIETIIEEDADLEPPQFPPSSPSSNHLAPPTPTSRSYTGRPRATSGASSMYSSRSRPPFIADCSDFPILPAPHYADGDMLAAPRSAPLLQSSRMRSLSQVTMQIGTPPRTAIPTLPASGPRETLLAPPSPSAGQTPSQLLFTPTQGRRRGLTTSTAHTAASGAGAGTVPGSPASGTWSYALGGTGGRAQRSKVRPRAVSSLSGKDRERVGGALWSGSRVAGVHLTPSMDMASVRDQMGEQRESGVVASNEGGSKTPVWDVFGVVQGAEAEQKEDSPDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCE3</accession>
    <name>A0A1E3JCE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032389.1">
        <property type="nucleotide sequence ID" value="XM_019175899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCE3"/>
    <dbReference type="GeneID" id="30192986"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="17796" checksum="15BFB69BA03E4532" modified="2017-01-18" version="1">MSAVKGNTALALNRVWHHSSAQNRVLGNYASRIAWVLMGKHKPTYDPAVDAGDYVVVENALGVRLTGKKSMDKVYHSHTGWMGGKKEVPISRLRERRPEEIIRKAVSGMLPKNTFRDRRLDRLKIFPGAAPEHYTKNALTTWRDLSAKTGAAESSSQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEV1</accession>
    <name>A0A1E3JEV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032476.1">
        <property type="nucleotide sequence ID" value="XM_019175373.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192454"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="204"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1287"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1612"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1612"/>
            <end position="1624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1662" mass="179927" checksum="C2524E3C5044CA35" modified="2017-01-18" version="1">MDHNLLISELQALAVETKRRNPEVKDASEAALVVLKDGPLPRHTLLDNADTLLSPVTLGCKTKTAKVIGISIAALQRLVALGGVPTLKLPEVLGTLSSVANQAVDIQLKILQTLLSILTFNKDVHDEVLGNTLLLCFKLQDSRVSVVSSTAAATLRQAVMLIFDRLSSTHLSPSLTPSEPPTPSTVSLTLPSEPPQTLQVTPSAMDAYSIFSDLCILAASAGAHGSTFGGLWKGGDAEKPKLLKLHNLQRTFALELIESILSGYESGVKKRPELLFLLQHSLHPLLLRLLSEKPTFPIALRVCRLIFLLIRSFIDQLPGEIEIYLASLIKIGAGEHEGDDVKVKENTPPWLRVLAICGDHALLQSIYTHFDEAGGSVLFAKIINALGRLINEKPALLGMGSQMHGLGVPTGVQADASGSNPSLHGGYLDMGLGMLGSAASAGVSTMNAMMAGPSGGGLGQYSGMKLKLIEQHDKSDAPIFPETYIYLVAFQSLNTIAQGIYTVVASKNPPPTCLQGMASSAWPALLAALSYSIGTNLSDTLFAEVLTALQDFTVACGLLKLGTPRDAFLNTLGKYAVPPPAVSAMQTYIEAPGQRNAGGIAADALGFASSLAGNAPPVGPPSLSDRNLACLRSVINTARVLGPTLGKAWHDVLEILQNANFMMSVSKQSAPRRYGGVGGSPKKAPPPTLGRAGETVEPKPPILQDLEPESIQQLINGLFDSSKDLPDEALTTFVTALCQLSSEMIGMETSQTSFFPDNASEVSLPPTPSSSAIFSPPLDNRRRTSGINVSHGIKSVERSFSLTKLKSVSTRNLKRIVTKEPAVGWDAITQHLLAVARHPTATSTIRVQASETLGELLLAAVRVGKESRTQHQVFDVLVRQVDAQPISNSLATDFDVRSSGYQTLNHLLESSGHSLQVGWGMIFDMLDGVCRDDKVNKEQLYPGDTSSEARRPATVSSKGSSNLVRIAFPSLTIICTDFLSSLDDDSLRQCIVSLGYFGAQKEDVNIALAAIGLLWNVSDAVQRDSKELWLYLLTQLLALGQDGRLDVRNSAIQTLFRCIEIYGSGLTSALWQDVLWKVIFPLIEAAEGEETQVLALTSVGSVFGSFLTLIADLDSFDEALERFLDRVRHAFTSQARACCTAGLKALEKVLMAADASRISLGDTMQKIVDASWLTFVDMGNAFTNGEPYTQGNLIALTRAGSLLHDNLAPHDIERLAQFASILRSIMTYIRSPDLRPDIDVMSPLQTSICEVIADSKLLGPHLVLSSLAEFAALAYVAVVGQRDAGTKLTYVALSKWSMRKIEDVFEESSKNKELYEDGTVESVIGMYSIPIKLKYDCPSANRFGDDPPLWRSATLAFSSILGWVIAALDNEDIESEKMERLWAQIMEVFGGMLSADSSGDVSSDDETFVVDHLTRMRDIVIPRLGHSFVPDRAISHFADVLSRASHLYQYDVRVSGGTTAPALPTTQEELRYWAFDLLVTLSVQRAEKEQDIQGRQRIAKLTLPSLLKRFNVSIRRFLEDRKIRGNLPLGRAREDELLYVLRHLATTKVWKGSAVDSAHVATKLALVYEDSPRAHLFQFYAPLLELSSNVDHTPSIWLLPSEHARLFEKSTEVEDGAVETREGEGDGSDNVGDGEGLIEVTARDLATRSLELIGQELGLMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF92</accession>
    <name>A0A1E3JF92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032579.1">
        <property type="nucleotide sequence ID" value="XM_019175476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF92"/>
    <dbReference type="GeneID" id="30192559"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="272"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN99502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="727" mass="80061" checksum="41E00ADD0B4F00DE" modified="2017-01-18" version="1">MGAKRKSSARQPPAISANHADSQPPLPSESVISDDPSASTTADNRLRKRKLDVNPSLIIPADGGRSMRRRSPSPHVAKQEGNADADPKDPARAKELGMRIWQKIMEAQTKDGEPMAEPFVKLPPKRQFPDYYETIKHPMSLEIVKQRLDKQEYDTLKDVVADIGQIFNNAKRYNVRESALFQWAKKLHATKEDSDSEGDEQDEFTSEPVHRERTETLPPDADGSSAREDEDDAKLLNKKKKGPYVAREGPTVYKLIKPVLKAIKEAKAYDGSGRLISDVFMQLPDRKDLPDYYKTIKTPISLEEIEAKHSGRRYETWEEFFDDLELMCNNAMEYNTDESAVFQDAKRIKDMFPQQRAETKLRLTLPPGTKLSARQKASAMIPVRVANPHLGYAPSTATVNSPVTATMPMSGHMTARGSHGFPGQIPTPSPGAHHSIPQTAYPAPSPSYSQSPYHGSHSLPRPGMSHTSSSSYLPALPLGVVTEEVVASLDRYPVHEQQQWLNSLPPHGVATYRSLNVVVEQKKRQAAAQAQARAQAEAQAQVQAQNAARVQAQAHAQAQAMYQSFSQTQTPSHVPSPSPAARSGASTPALPTPQAERRPPPPQPLISHLDLSYTSPSAFGSQQQIIKLRNSRGVVAHSILLDCNTSELEIAAYPDLALAAERGDQQDEQDMTLHLNGVVSSTGRVVEKEGMKWTVAVPLSKNENRIEVAVGKGGSQGETVIIYLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFM3</accession>
    <name>A0A1E3JFM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032552.1">
        <property type="nucleotide sequence ID" value="XM_019175449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFM3"/>
    <dbReference type="GeneID" id="30192532"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="777"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1279" mass="135226" checksum="C8238FDC5F544405" modified="2017-01-18" version="1">MDAPQKPSLFASLSLPRTSRHKEPLAHPLLAASSPTLADDTPPTAPPNLRHKSSGSWSKSSPPDTLPLPYKPRQRHGGGIGSVSSTNSIIGTSAGGSSPTLQPAALPGSNAPPSPVTPTAVSAPPTTSTSTSTTFALPPSHSDPPAQANESAVPITASATGTSSLTSRLQLQSLKAAAQGVGLGNGSMGMSMIDAIFDKGQLGRAKMGEGGDWGELLRILIGGQAILLLPTTPSSSLPMTPQTLRDHVTFISPPVHSGEQESVSVIVTLSGLIGTLKGRNITIESAIPPDSPLLRSLKDPATRQSILASLRPAQTPSSAFPCLTLSPESAVLSFPPPSKAPPPHTPETKEKEKAQPGKLGRINPFASLFGGGGSNHASPVHDNKALATSPLLRPEALQPDVLSPPRSRPSSPGPLSPKPSTINLEADASSIMSDSNRNGEGFTVSAYTVSKTIRFHETHKALSKSVRVHIKESLAGLPEKAVDKVVRLGVANVCPTPQGSEELLKGHKSGHHGVDLDSILALNFSDPVETGERLQDFMESIYDDLFTQYRQDASEGLKRKASGGSWARSQPQEKEGENEKDPKARKEKERREFEEMIEKEASDGTERVEGLLARLLYNRLFSPWESDDSRHDEALASRIAALNMLDLSLDHLGLITQPDGEEPEGTIANGLYNIVESIGDELQKLSRADCLTPKAKTDVLIKAHKIVVDGLDNLPAVQLRPEGESYKKTKEPPLIPEDPTILEPLPLTQTSSRSSNSSKRSSNSNNPSTMTRQSSASSGDRSVKSAVSDPLSVSAVDDVEATPQAAVLNPDLNKSPSVPQLVLDDDETSEPAEEAQLAEAMSDSVTTLTETSSSVPPPKPQSTKAGTTSGADLMLPIIIYAVVKSNPPQLASQLMYLRRYRSAICLTGEASYAIVNLTAVVEFLEHVNLNELGLGGEEDKVMSIDDLSPIGLGYMAEGNVDAASIASASSRLRGRVGEFAGTAAGSANKVISEVMDSSWSAFRGFMGNNNVALNGEVDENALATSAEGTRPGMRPRQASTFSLASVTASVAGIAAAAAARNRSRATSRASEQVWGGTQELVEVSSRPGSIRERESDYPSSDEESSEEDEESSEEEEPELKEKGKGQPQDGKEKDDTPKQERVSLSNRLASIGVLGRLGSSSNTPPGDSTPAEAHPVNKFFFQNHNHPRAHGASDQGHGRRSSLLGGNPIESHLTRAANSPKGSTASLSLSNSGDALEPPIERFMTCEAGDIRVSEIGVLLRDYRRLGAIVDALNKQTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI92</accession>
    <name>A0A1E3JI92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032796.1">
        <property type="nucleotide sequence ID" value="XM_019175064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI92"/>
    <dbReference type="GeneID" id="30192137"/>
    <dbReference type="OrthoDB" id="10439117at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="26227" checksum="BC47BE7351039C58" modified="2017-01-18" version="1">MSSARDIAGNSKSNDTLPKVQLVATPLEDSNPTTSSKPRKLLSDEAEKYVDAMLTRPDGTKGIPPLTPTPATQLDALFPGPEPETLRELKEEINHLLTMVAHLEEECRNVQRYGKVRGWGNTRACKMINHFEDDFDYFDDFGSDGDDDDEDYEYECKELRADLQDLRKQVKAREQDLAKLVGQKKGKKGPVDVDSVYLTDDEEEDEEEDDEDGDDDEEEAEPSGRAEKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIF2</accession>
    <name>A0A1E3JIF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Importin beta-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032842.1">
        <property type="nucleotide sequence ID" value="XM_019175110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIF2"/>
    <dbReference type="GeneID" id="30192185"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="927" mass="102035" checksum="C58F41DA1582BAF5" modified="2017-01-18" version="1">MSWQPSEQGLQEVLGMLRDTSSTDSQVQRNVASRLDQLRYVPDFLAYLAHVLIHCTTELDSHRAVAGLLLKNAVNQRSGPPSNENDIRAMAYVKSTVLTGLADPDQIVRQTVGTVIMSLISNEESAGWMEALEVLTNGMNSSDPNVVEGSFNTLQKICEDAPHKLDFPWEGRDFLDLIVPLFIQSTGHDNAKVRLYALNILQSLLSIRVNALNANIDTYISALFARAGDGSSDIRKSVCASLGLILASRPDKLVPEMNNVVQYIVYCTKDKDEAVALEACEFWLTFAEDHNLKEQLRPYLAQVAPLLLDGMVYSDYDIAVLDIDEYDEDVADKETDIKPRNYSSKVHASHESNDPSSSKAQGVSREAADKAFDDDEEEYDEEDDDDDFFDDEDATGEWNIRKCSAAALDVMAVSFGTEVLEILLPFLRDRLFAEDWTVKESGVLALGAIAEVGCIAGLEPHLPQLIPLLITCLKDKKALVRSITCWTLGRYASWIVQTNPQDKTAYFFPAMEGLLTMLLDHNKRVQEAGCSAFATLEEEAGAEMAPFLEPVLQNLTHAFSKYQQKNLLILYDAIGTLADSVGGALGQPAYLNILMPPLIEKWQRLEDNDPDLVPLLECMSSVAIAAGASFITFTAPVYQRCLNIIHSTLQQYSAFEQDPDGVEEPDRTFIVVALDLLSGLVQGMGEQIHPLIVEGQPPLLHVLLLCLTHTEPPIRQSAHALFGDMAISCFPIIKPLVPQIIPAVIEQIVVDVPIDCISVCNNAAWAVGEVALQYSSDASPLEPFVPGLIQRLIPILTSPKSPKSLSENAAVTIGRLGLVCPALVAPELPNFAQAWCTALWEIKDNDEKDSAFRGLCMMISANPDGIHGSFVFFCNAICKWQNPSAQLDSMFRSILQGFKSGLGAGWESQISNFPPVIRQRLAERYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIG8</accession>
    <name>A0A1E3JIG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032830.1">
        <property type="nucleotide sequence ID" value="XM_019175098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIG8"/>
    <dbReference type="GeneID" id="30192172"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48774" checksum="85CA140D61F76521" modified="2017-01-18" version="1">MASRASSIRILSSTATRNIPKTRSFTRAYSSAPEDPASPSKAKALIALGATGFAVGLGIELTKGYRGTNVARCDGAPAVEAIDTHGHPWAPVDCIEQDDPSNPMRIRMATWVKNLQNHIVNTMEEIEASSAPNEFAPSAEPPKFLRDTWLRKEGGEGSSCVLAGGRVFEKAGINVSVVHGMLPPRAQKAMLPDHPSLPEPTDTVPFFATGLSIVIHPRNPHAPTTHLNYRYFEIDDPATGKPKAWWFGGGADLTPSYLDEADAVHWHQTLKDACNKHDARYWPRFKKWCDDYFLITHRGETRGVGGIFFDDLTTSTPLHAPVDPATPPPSPDQIFEFVKSASGAFLPAYVPLVYKNKDKPWTAEERRWQQLRRGRYVEFNLVYDRGTKFGLNTPGARIESILMSLPETARWEYMTDLGREGAGTPEAKLTEVLRNPRDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY2</accession>
    <name>A0A1E3JIY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032987.1">
        <property type="nucleotide sequence ID" value="XM_019175255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY2"/>
    <dbReference type="GeneID" id="30192335"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="77"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="28595" checksum="37BE56A15C9BCA0D" modified="2017-01-18" version="1">MALASSSSSVLKSAQAAPLKRLTSQARTYATPAAATSTFSPPPQSYPSSSTSTTPSAAQSYLTNLLSLPPSRQFSPSLALQILTHKSYRFSHPVRSISPEDPSAILETSAPHNSRLAFLGRRALTTYLALFVHEQYAGSSGKLQEQGGDFLRGKELDERLANLRHPSNLGRVLGGAWGLEEVMRWDRNITGHATGHASVKGQAVEAVMGGIFTQFGSPAAHRAFHLHILPKVASQLRDPFLVEKVQSVREELEKEFGRGILPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ63</accession>
    <name>A0A1E3JJ63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032868.1">
        <property type="nucleotide sequence ID" value="XM_019175136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ63"/>
    <dbReference type="GeneID" id="30192214"/>
    <dbReference type="OrthoDB" id="2561956at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="34421" checksum="492A1DD3D4455488" modified="2017-01-18" version="1">MSDPPPPHRSPISTIHIPSDAGPPSRRSEPDRQSLSDLSLHTLRRTTLTKAEQQRVQELIKSGGHGRMIAGEGLPGRASEVEDDAKYWTARGTLRSVLPGSDEGVQGSASEETSRAAIEEREVLVLVHEPNSITGPDGRSGQTPSEAGTLPSRFLYIFHPPDPPSTSGSANGSSFPLGLQWDEVNPWEWIETAKNELEKAFWGVLMPGVKGLVDMGEAVASIPALLSPGTEQALELQSDRHSADATAGSHNPHRYSQETVYTLRIPKQNARDSPNLGPTLRPVLIKKRSSIPTWEDGRDSDHRGWGRDPMAMGAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMD2</accession>
    <name>A0A1E3JMD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033068.1">
        <property type="nucleotide sequence ID" value="XM_019174689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMD2"/>
    <dbReference type="GeneID" id="30191756"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15861" checksum="1C433049CACC65D1" modified="2017-01-18" version="1">MQQEKASDEGECPIQTSITDVQAILQRGKDQAEFNDSLVSKDKYFRFKTSIEPALPICPADSTCTNLGKELGITKNKRSFEIFVERGLHRTMIDDLYGHGYMTCQSHSDWTPAVGEESLSYQKAVKSPPARQKRMVINDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMK6</accession>
    <name>A0A1E3JMK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tip120-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033336.1">
        <property type="nucleotide sequence ID" value="XM_019174957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMK6"/>
    <dbReference type="GeneID" id="30192028"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1265" mass="137017" checksum="09A3C7676F5A4338" modified="2017-01-18" version="1">MSKPVPLSSQLPGLLEKMKNVDPDYRRVMALVDLKKELEKNIAANGVTSNRRTDPHFTDDYTEGQLVDMALKLLADSNQEVKSNAVTNIALIVKKARPTSLSKIISSLLEDVASGNEERRDTSTLALKSVVLEMPSSGSQVSADLERISSRVLELFNTADLHPQIASELLQTLTDLFTRFSANVSTSTTVSNSSLSALIKILSTARPAIRKRAIPTLASLVAASPALFNETLQKEITAGVSQSGDSGRVWLGVVASLAKGPNVGNVGKLAAEKKLAEIILQQTKNPEEVETVEAALTALEALVLRCPTEIGVYISTITQKSLALLRYDPNYVNNGDDDDVDMESDEEEYEEDDEYEGADYSDDDDDSWKIRRSAARLLLAIISTRPDLLSEIYGSSAPVLISRFSEREESVRLEVLAAFEVLLKQTTALRTSDIVTGSRSKRKRSEGMDEDYAGDDGPIPALRSLLPQLSKATLTQLSSKSVPTRQQCFVLLRQMVQALEGGLTDSVDPICTSAASALRTVDSATSSSLAIATLSFLAVFFDNHPARVFATHLKDLVPAIVRCQRDKLQRISFEAFDTASALANSARPLGSTASIAPELENAVRLIFEATTDILGDNTVDGDVREKALSTLGNVLIHTGDLFTSVYSECLDLISNRLAVESSAPTAISVIGQVASSPLVKGPEFEKWLLETLPQVVVALRRAKKGASKNTEFACLASILERIGSSLPEDTAEGIIVELGPLIDTPTALQTAALILTQQPASRSAVDTQLYPKVLAVLKSSINPHLVESLVSFFSAYAVALDGSSRQATKAIQQLIGNLNGEKGLPDATHGGTAAWATTAKGVGAIVKNVPAAAAESLQSFEQVVQSGAANEADAYLALLCVGEIGRGTNLSSRQDLFAKILSYFQSESEEVRSASAFAAGNLAVGTPDVFLPIIISKVESAEKESERLLLLHAVKEVILHSSSAQLEAIADRLWKPLFATPTSVANNAETAGDDGIRNVTAACIGKLTITAPTKFLPQLQQLLQSSPANRALVAAAVRYTFIDTSNGYDELISPIIVDFLSLMKDENLIVRRLSLASFNAAIQNKPHLIVDKLDALQPLLYGETFVRKELQREVIMGPWKVIEDDGLENRKTAFETMYTLLGTCFSKIDLPTFTDRVLASLSDVNEVKVLGLMLLLRLGQTSPEVVQPRLDEVVGEFQGMMKDVEVKDDTVKQDLERKAEMQRSTLRTVVPLYRACSVQQAPGFHQFVTQVLANDKWKEFKDYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMM5</accession>
    <name>A0A1E3JMM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033158.1">
        <property type="nucleotide sequence ID" value="XM_019174779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMM5"/>
    <dbReference type="GeneID" id="30191848"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="8ECD9EACB49FF0B8" modified="2017-01-18" version="1">MSETISQGKTQDNPSSITDSFPDPRVTHPWAKTEEDELVIKMHALLQMADRQKTEYWSRNFKGTKEELKSRSTYREPYIDPGIDIIDEGASTSINEEDPQSDPAGHSRLKFEGEPLIPTRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPW8</accession>
    <name>A0A1E3JPW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033204.1">
        <property type="nucleotide sequence ID" value="XM_019174825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPW8"/>
    <dbReference type="GeneID" id="30191896"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="867"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO01952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="914" mass="101508" checksum="06E26F39C70D6F1F" modified="2017-01-18" version="1">MSANYKQEESTARQPHAKENEEQTANKKKLSCAECRRLKLKCDREVPCSNCVRRGCRELCPDGTKETRRGGLDAKSSEALQKRLTTLEGLLSEHGFEVGEDSSIQRRPSRRDSDVASVHRSSILGEDWKPNRGTSESPYYSTSNRRSRSPSRGRNEMQASRYPISNSPGTNPFSYPSPNGGPSSSQPSSIVAPHPQLPPISSFNTRGSAPVGSPVEHSHGTLVIGKSGRSRYLGPTAGTEWLKNQEMGGMETPGHSRSPVAGTSALANPQIPSKSYSDPLYSFPFNEPVAAADVETLFSRLPARGDAEVLVDSYYRYFAWNHDPAPRKTFQPIFEKVYDASQRPQPEASVHLQQLALVYIILAMGTVHNIELPPHDESAEEYLALAKGSLTKGNFLNHGTIAGVQTLVTMAHYYLETESGRNGDAAWPLWGLAMSLVVAMGLHRDGAKWDLPEDVVHERRHVFWECHTIEVFQANCFSRPNSLANKFIDTAFPSPNPSEIAMGGKGWPTLKFELCQISSRILEVGLTVNFQAYDTIQKLYAELCDFELNVPYDIRCRCALLALPSVYPDANMARRNSPEVSRHNLHRTLQTYTLALNIAEAILFLQRPYFVMAMHDAPNDPTRSLYGHSYLAVVERCNVIIQVVSDLYRLHPTIISRQWFFWYHLFTAAVCLGTLILKNPQSALAAFALSQIEQAIQVYSTLIKQNNSPSMVQNHDWLVRLHQRSAKKIAQTSATAGNGTGPHTWKDDEQGQEEEDRELLGWKTRLIERAASGAHKAINIPSKPIIDQRTPSPMVNNAAMTPAMHLLQQHFVPPLDRPPVSGMLGTSAHTLGMDNSTDLLLHQFWDPMMMPDGGNMTSANWWSWDLGMPENGAPPPSNPQSASQHTPQSVQNTTSQTPAMSGTVPEYRPPPSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH6</accession>
    <name>A0A1E3JRH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033521.1">
        <property type="nucleotide sequence ID" value="XM_019174469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH6"/>
    <dbReference type="GeneID" id="30191530"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="150"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="929"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO03470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="964" mass="106598" checksum="B90F27E8B9C9F9B8" modified="2017-01-18" version="1">MVTITPLVDGQDRSIDARSIVTLIFFFAINALVIWPVRIPVPLFVSRLFGRFVKRSHKDKAEEKCDPKRDMSTPAPATERGQENTTPEASATINSQHSPAESRVPSKRVYIPIDLRTAPVIGVLILLAFSIPGSVVRRGIVGSGGVRPYDIMTLFICFAYISISLDTTGFLRYLAFLVASRASRGQRLFTTFYFLFAGIGLVFGNDPLVLSGTPFLAYFTDHAAISDPTPFIFSHFQVSNLVSAFLVSSNPTNLVLTSAFAINFLVYSAWMAIPTIASAIVLYFVSRYITFSRKGLIPTTIHPPAINPRDALLDPVGAVFGATVFVITVLLLVGLSAGGILEGKVGVWTVTVPAAGLVFLRDLAKDLSERREKPKGNSKPLDPAQSTLPTEEIAAASTAAPSHPPFLGLSRVSSVVSKLPLALLPFAFSFFILVEGLQHTGWISVFGGWWGAWEEVGGIAGSVWLMGMLSVIGCNVFGTNIGATILLARVIQSWSLTHSAVSERSIYAAILTLAVGSNFGAYSIVFSASLAGLLWRGILRQKGIHVTVTQFMRWNTLAVLITMAVGCLIVAIETRFPQRQMAPYLEQRIPVSQASRYYSPDSPLSRSRSRGRSPGRGEEGMRMSGADTPYTLDQDDGDSQANPILEPYHNLERWTYNDNHTWPHRPKDEERAEQVDWIKLQSDSDCIRSMMVIKEEPVDGSEIDQDRRTAFQKLGLTVRREEPISYNLIQEITLPVPCPPEAEGGDDERTSVSKIFIWDHLEGEHNPYGCGGSICEGYPYDTHIVSGFEERSEGACKPYHEFTPELIEDVFDMLCRRDTFAEVDTGLPPDAPLKEVSIKVATFNAKSDLSTGIGVVEEEKMTRIHHEICGTEFCAGSRTEEEARNELVEPEYLGDKCRPDVWYIFEPEDGVAHRHSRLVLYDEAFQLDAEPGEPVHLEQPEQVEEPEEPEPEAPEEPEEFEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRV6</accession>
    <name>A0A1E3JRV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033635.1">
        <property type="nucleotide sequence ID" value="XM_019174583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRV6"/>
    <dbReference type="GeneID" id="30191645"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="128"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="42763" checksum="5327A944A06BE3DD" modified="2017-01-18" version="1">MSKPDEIPALSFILEPAIVVSLLTAGCLFNRRPPPLILQAHNAVNDVPPPPGDNAWNWKNMRSFRWTVRVPGNERFRSRWSSGLLGMFPFLMEVWYWLLTYWIYQIARAMQALTMGADFRALAEQHARQIIAIQRWLAIDCELALQKFVMEREWLLVFFNKTYAMVHIPATIAFMAYSYRYFSPLVFQSTRRTLVLCNCIAFVVFSSWPCMPPRLLPYEEFGYVDTLHTGKAASIWTTNKFQNQLAAFPSLHFGYSFVIGLSLFLYSPHRPIRAVALGYPVLILLVIMATANHYLLDAVGGFFVTVLAHRMNRLTLNLRPLEEWFFWLLRTERPMDKVQFDSVINRENVGHRDSSDLSHRPLMFGQDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS00</accession>
    <name>A0A1E3JS00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033710.1">
        <property type="nucleotide sequence ID" value="XM_019174658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS00"/>
    <dbReference type="GeneID" id="30191723"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO03659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="73" mass="8201" checksum="01DBC57AEA24F30A" modified="2017-01-18" version="1">MDRRLFLHLQGGRQISGVLRGYDMFLNLVVDSAFEELGAGQRKPAGMVYLSFSVFLFDGFVLSAEGNRAERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS58</accession>
    <name>A0A1E3JS58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033557.1">
        <property type="nucleotide sequence ID" value="XM_019174505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS58"/>
    <dbReference type="GeneID" id="30191566"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50252" checksum="6DEAB06D19A4EC80" modified="2017-01-18" version="1">MSATGIVFSIRWCEQFFPDHRKTFTTSPSRGSKTPLLHIHTMWRYPASPNHISAPTTRSSTPDLAPTTSRDDSGRPLRLAPQVNSYSSPKSSEAEMVRFESNVSRQTSSLAEKRKRSPGRGMMPKTGSPWLASDHQTLSGNRTVTPVAGSLNGWDAIPAGEEYYGNGYEVPRPDYGQLPAAGFTSVEQEVNQLRTNLNEIISLLQSFAPSAQQPRPPPPPLYLTTRFTRLSSSVHQSLSSLAPHLHTNLAPGFIPSFIPPATLLAPAPISPTASTAKKTDPESSTEAQTRRKKVEVQAEEHNLDQTRLEEEMSQAEREMEVIRKRRDILIARAQAAAAAGHNSVGGRPNSKLRPPATSSYSGRNGINGSPGLGNFSALSEASEIASSRLLQHRGLGEDVPITAKSLSWVGRCHGCGIGVRDGWREGPDGPDTLCESCGGHYERLTRKKVVEPYRDSDTESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTY4</accession>
    <name>A0A1E3JTY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033638.1">
        <property type="nucleotide sequence ID" value="XM_019174586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTY4"/>
    <dbReference type="GeneID" id="30191648"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50949" checksum="1452C4BBE214F055" modified="2017-01-18" version="1">MLETRQTSLPSLVLASPSAPSASLLVPETNRTYGSIPHIPSLLQTQSPRSSSDPRGERPPLPRINSATPLIPRSSGLYRDLRRGHWHFPWQGHRNCRKQRSCRASGLTGSIVIMTGMLLGLVLGVMLWVYGWMGREERLSVFDLMSFIDGNFSTKGIKKMWACSHNDEMQGQNALSLALSLGYGWIEVDTHLAATPPKHHPDHVTWTLLTGHDLADLDPRKSLKMLYLDPLLAILDMNNEGWGKDGGEEWNGVYEDDPREEVVLMIDMKSDGDETWPHLQKALEPFLAKGYLTTYNTTSQTLSPGPLTIVGTGNTPLHQVFYAPLRYIFFDAPLVDLHKPHHLPATPSGPAVTIEWSPSLSPIASSKFPLQYYLAAPPTPFPAYNPFLCNLQLTAAVAHEKGIQSRWWGVLHKPGWARRRMWEVVWQSGVGVVNADELGGLESWLEGKKGVEREGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW34</accession>
    <name>A0A1E3JW34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033723.1">
        <property type="nucleotide sequence ID" value="XM_019173916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW34"/>
    <dbReference type="GeneID" id="30190968"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="429"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="725" mass="80238" checksum="D9DCCA68DE6EDB2B" modified="2017-01-18" version="1">MSAVSEQIAPDEVTQQLETLQIDPALPRQSQGKQPQGGQRSPRQAASANASHTQPYQPYAQAYTRYPQQYQNPYPSYVPYSPYGPEQLGWRQPDSEQPSPINPSNPTFGVWSSPPVSPAVGAPPPFLNQQSRHGSFDAAGMPGGSPVYFDSRSSFGGPGPAWPYPAAPSHFGYYPSYHPSSSPLEPNMAQPSNWSGSPATPYGPGPNHNRVSVSSASRPSPTGGDSKEPERKPYHPQPPSRRSDWVMWVGNVPSNTSHEELWHFFNMTVPITDPITDTAPWRGPSSIFLISRSSCAFVNLSSQAELDRAVAFFNGKPLRPWDARCPRMVCRVRRKDDDLKSGVGAQRGTGIHRDWVKKEQEKQQVAPQGLEPIATAEGQVPAVSLANPAILELSEEGRKRDSSGSEDGKKASGSYASTTSSFLIKHFPRRVFIVKSLTTAELEESVRTGTWRTQRHNEPILDQAFRTSQSVILIFGANRAGEFFGYARMVEPIDKERAKRQQSSISSSAPMRSGTQESSFFLTPQQSRITVLSPGELHSREDSYFHPIHRNTDPPKIPNHAAGSNSMSLQVLDETRAHTFDPKTLQRDYFPSVTLAMAQEGGDVPKQSSLTVVSEPQSVEDLQRKETLPPPEENAKREKQNAQEEFSDDGWGHAFRIEWVKVAPLPFNKTRHLRNPWNADREVKVSRDGTEIEPTVGLQLVAEWDKPEIAPRLPSNGSNPSSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW65</accession>
    <name>A0A1E3JW65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033754.1">
        <property type="nucleotide sequence ID" value="XM_019173947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW65"/>
    <dbReference type="GeneID" id="30190999"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="892"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1239" mass="135133" checksum="3691B04B0D199E68" modified="2017-01-18" version="1">MAPLTHDFPTFGHYAHNLKDGLQHTASRGLDELDQAIETKGYDWLEGYMAQIFDRLPQAPIGELIKTPSKTQTVKKTRAAIAAAKEKTEKIKGLNARLALSPSNQVNRPALSPLHLGARSININTSPSPSPVKSKPAKPLAISSPVKSKAKRGRPKKADIANDSKSTRSKKADGKQPEVEETLATEPQAQEKEDPAPQASPAKSTRSKKAKQTEVVEPPVEDVEQAVDEEERMAGEPDKESEADNAQEEPAPAPVVAEDMEVEPEPVAEREEAVEVEKQKETAGPAMEEVQQQVEEPDVPMDVEQVEDEPVAENVAPEAEPEVNREPVEEEATEPIVDKAATPPMAGIPVEEPTAPLHPEVDTRVEPEIETNTETAPEVISEPAPTNISQTSFTSNSQPAHRIRSSWLSKALGTGAPPLAHAHEPSALRKSHATSSQPDRANMDFSGLRKSLAPISGLKRKSDEGLDNDEDEDEDEHERAGKVAKASEAHTIHFPTTTPGPAKASLFPTKTPSSFGTASVGSDQHSQGRPVQDDSQRPEISRVTKALDELREKTAKDLAKQKATPAAGTAARVPQAKSTGAGFLRGLLNFGGGNAESGEDEATRRARELEEEKIAEEELEKLMWAARNGVDEDMILGEEEEEEPAPQAVEKEEPRSTTPSFSPPPKPTLRHSIHPSYMPQPAALPALVAPVSGPSAVPTAQAGTMTDHEDEEMVDEESVLDEIIPDEVTEYQPSHSRTSSQGQHTRFFSPVPASTTPAKPLDKEAPALHDRKEKHQHEPSAAVLKEQKEREEKDRRREEREQEKLRLREEKEREREKKGKGKSVQQAMETPSASHASLFTSTSANTNTTLNHASIMAAKALGVKPAAAPVKSVQQAASAAQKEQAASVRKAALREQTEKRKEQAAQKKAEEERVRAEEERKAKVAELEEKRRIRAEGEKRRKERELKAKEKAAKEQADEAAKVKAEAEAAKKRKLAAALNKSQTAAPAPKRVAAPSQSLAKGKEPFRPTKTTLSSSITADSKMGPNAFRTADSQTQSSTIRLVGQPAQPPAQRESQAATWSAPERKPLGQPSRPSQMEGHGVKQSLLYQAHHQQLQSINTQPQAPPQNWQQVQASLDKKVQQQDSEDIVLPDIASEYSDPDDDTTREFNRPDWAESPALNKALAAQATIDPDEYFGHIGPLNMEELFKARAGKFRPRSSSANWSRGDGLSPMEIIDYAKRMGYESLQSYDDGPGPSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX10</accession>
    <name>A0A1E3JX10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033951.1">
        <property type="nucleotide sequence ID" value="XM_019174144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX10"/>
    <dbReference type="GeneID" id="30191201"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="155" mass="17118" checksum="4C8AD6812B7D3746" modified="2017-01-18" version="1">MWLSDSQKIGIALVAFGIFFQFLGKSYHDCLTDPTDLYLLGIILFFDGPFLALGNILFLSGLPLIIGPTKTFYFFSRREKWRGTLCFFGGIILVFAKRPVFGIVIEFVGFVGLFGSFFPVILQALRQAPVIGPVLSLPYIRGAADKLAGVRQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYH3</accession>
    <name>A0A1E3JYH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033912.1">
        <property type="nucleotide sequence ID" value="XM_019174105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYH3"/>
    <dbReference type="GeneID" id="30191161"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16640" checksum="FF29A695E12AECCB" modified="2017-01-18" version="1">MHSKGKGMSASALPYRRSQPSWSKATPEDVCDQIFKLARRGLSPSQIGVILRDSQGIPQVKSVTGNKILRILKTNGLAPTLPEDLYHLIKKAVSVRKHLERNRGDKDAKFRMILIESRIHRLARYYIKTQQVPANFKYEAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ55</accession>
    <name>A0A1E3JZ55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034199.1">
        <property type="nucleotide sequence ID" value="XM_019173494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ55"/>
    <dbReference type="GeneID" id="30190543"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16298" checksum="779C187405C3EA5B" modified="2017-01-18" version="1">MPSNATTTPTAPASEVVAGGPATARAPAKRPAETPAVSAGSSVFKRAKVELEEDLASQDKEELVALVEKYHRLYIQSEATLENASQIRQTIQTRFEELEKKVERERVEWKEETDQLKKNLSFWKGKAFSMTTMKTKKRVMGRNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZA0</accession>
    <name>A0A1E3JZA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034334.1">
        <property type="nucleotide sequence ID" value="XM_019173629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190679"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO06234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1427" mass="157086" checksum="A8DC790F2C557508" modified="2017-01-18" version="1">MSRPHLQGQVSFQDAVPPSRRAGRDDVPPRPPAKTDNSKNSLQTTDTVQSVGPGGYANPALGYDEGGYMEAGASSPGFSAAGDIRRKKSMVRPERERMDPNHRLWHYREHAAEDQVDVQPSSTGNQPYHLRTNGGANLRRGKSLLAREAEDIDDSSGLNLFKRGATIRRKASRAAPRQAPPSGAQSNRAGAGATKPDEADVGCCACLGDFAPGPKDCWMTYCYLITICIPGFVIRGIFGKKTPDAQRAWREKMGIVSIVAYLMTFVGYITFGFTQTVCGDTDLRIEGGLASSGSLVINGYDYDFSTWSHPAAGSLFNGSTSPLYMDEYMAGGMDASFMFQNVNEHCLDIITPAPDTGIDYSGSSLGWYFPCNLHDQNGTSAVNLTGYTSSYQCHTSSTARDDFSAIVPTAEIYYTWDSVKSEDRNLAVYKSAVLDFSLLQWLDDSEVSYPAFFDTIKTRNSSYAGKDITALIERAGLTTIAQCLTDVVQVGFVDSISIGCVASDIVLYVSLVFILGAVLIKFGMAVAFGWFLSWRLGNFTGESYQERMKRAAEIEQWTDDIYRPAPGYLRPNAATGNGAKAGGLKKPFLPTTSRYSTAAQLHVSSNSRPSTAYGMLGDRGRQTSSVYGNKLGPPTLLTTPPGSPLLRNSRSSTSLPFRDDSHMSSSEHSFGNQSPCPFPLGNVVPQPAADFEPFSYPLVHSILLVTAYSESIDGLRTTIDSLATTDYPNSHKVLLVICDGMVRGSGSKQYTPDIVLGMMKEFIVPPEEVEAHSYVAIADGHKRHNMAKVYAGFYDYDSSTVETSKQQRVPMVLVAKTGNPLEANEAKPGNRGKRDSQIVLMSFLQKVMFDERMTTFEYEFFNSLWRCTGVSPDRYETVLCVDADTKVFPDSLTRMNACMVNDTEIMGLCGETKIANKSETWVTMIQVFEYYISHHLTKAFESVFGGVTCLPGCFSMYRIKAPKGDHGFWVPILANPDICEHYSENVVDTLHKKNLLLLGEDRYLSTLMLKTFPKRKMMFCPQAVCKTIVPDTFRILLSQRRRWINSTVHNLFELALVRDLCGTFCFSMQFVVFMDLVGTLVLPAAISFTLYIIVVSIIPQSVTGIPRPTISLILLAFILGLPGVLIVITSRKVAYVGWMLLYLLSLPVWNLILPGYSYWHMDDFSWGETRKLELGEGKKETDHGAKEGIFDSSHIVMKRWAEFEKERRWRNGTLERDSQYYDVVQRANSPRNAALPSNRYSLASTSETYNSGFGTQESNPLFRQSQSFASMSQAAPSPEHNYGEVSQLALPPARGAPGREHSPSSTESGTSNLLGQGSDPSSSSHADPYSYQSYTNEGYPDEAEQPILNNDYLPASPPEPAYRTALQPSQSQRGVSLVDTGPVRTAVNKDAVRRVSRHNRRSSSKNQLVSPISSGGHSSVLPPGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZB5</accession>
    <name>A0A1E3JZB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034213.1">
        <property type="nucleotide sequence ID" value="XM_019173508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZB5"/>
    <dbReference type="GeneID" id="30190558"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="438"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="870" mass="96662" checksum="8A983F1B380B25F7" modified="2017-01-18" version="1">MPPPAYPWANAAPSSRLSPDMSDRPQHQRSESEVIAASALRQPSTIHRSNASTPPSQHSPSGLRSRPSPRKDKGTHVLTKPKSSPNLSVPSSARDSTVRHVSHSSGAERIIKGTSRWLRDKLDMGGAEKKDDGWLILDLHSPSVVSESTNSRAVPAYDQRGYPTRQASFETARPVAGPPTPHSPTGPLISDPEIRNYLSDSHNGRHPQGSLGYSHKASLSPLAAHFPVGLSALDTSAESDFFPGGHSNLSFGSGPRLAPSIYESSMRSHASLSSFQDSDTDSVAQLREDDPFTRVMALGAGINGEKERRKRNGLQSMYTLKSLRLRPNQKKRENSKLFDLLPFHIDPSQWHDMDPEEDDSLHHPDAMDKHDTAYFTKRGLANLGCLLFLLLAVVMIFAGYPVLTYYYPPHHMDNNVGYNLGGINATGQVPSITNFFQLIDPDTPPEAYTHMSAETGEEWELVFSDEFNQEGRTFNPGDDPFWEAVDLHYWQTNNLEWYDPKRLTTKDGKLVITLDKIVSHGMNFEGAMMSSWNQFCFSGGYIEGTSILFLAPKLALTLWPAIWTMGNLGRAGYGGTLDGTWPYSYDTCDVGTLANQTLNGKPETSLTNGDPNNGNELSYLPGQRLSSCTCENDPHHPGPKHEDGTWVGRSAPEIDIFEATIEDRKGKVSQSGQWAPFSSHYYFKNTSDNYYKIYDEDETQVNTYMGSVYQQATSAVTVTKQNCYTNEKGCFESYGFEYEEGSDGYITWINDNKKAWTIRGSAMGPDEEAEVGQRIVSDEPMYIILNLGISENFGAIHYVGLDPLWPISMEVDYVRVYQDPKKRNIGCDPADRPTAAYIAQFPEAYSDPNITVFDNVPGATWPKNRLIDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZJ8</accession>
    <name>A0A1E3JZJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033987.1">
        <property type="nucleotide sequence ID" value="XM_019174180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZJ8"/>
    <dbReference type="GeneID" id="30191238"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="167"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="290" mass="31814" checksum="74D8F2BEDE90AAD2" modified="2017-01-18" version="1">MSDLDQAALDAIIEILMTEVAEELLDECKEPEPLHNSKRTVQMALEEFLEGRFRSQGMRTYLGTTPIEYVTAEERLFTTFWILRTGASFETAAEEFARSPETISLSFHAVILALCKVKYTIHGSSSQHEKALSTAPISLSLSGKEYNELISTERDRHLPMYWLPGHSTSGSPVDLTERTLVPLVRVATASPTLSKLGPTAKSASPLHSFPTIPAFCRPRTDESIADYDASNPQGPHFTQVLWKSSTKLGCAQTSCADGIIFTGYGDSPFIVCEYDPAGNVAGQYGDNVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K058</accession>
    <name>A0A1E3K058_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034580.1">
        <property type="nucleotide sequence ID" value="XM_019173875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K058"/>
    <dbReference type="GeneID" id="30190925"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="20142" checksum="1BCFB8DED70A014B" modified="2017-01-18" version="1">MVIVKRTSAVRRRASKPPRHPTFTTSGPLCVICVSDQAPRKSSDGSSIPIFCGTCEGGVYAEGAILQLIGKMDDELIEHEVDYLHDTEQTGLFGTSPSRIGDTYKQALLDLLEKCSYLDDLITKTRQRFPSVKASEAEVRDALRQLDTHLETYPSSYFDPKLDLRVPTIVIGDHPPAFALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1N0</accession>
    <name>A0A1E3K1N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034447.1">
        <property type="nucleotide sequence ID" value="XM_019173742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1N0"/>
    <dbReference type="GeneID" id="30190792"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1085" mass="116438" checksum="7BBFB6C81DE4E0B2" modified="2017-01-18" version="1">MTNSQTNGDGANGPSPTVPQPQSAHAPLSGQPSPLANASSVQPHGPSPPQAQGDHGAGQDLSALDDNSDNAKRPRLRLAHACDRCRRRKIKCDTQHPCTPCQQSNNVCTFETPSRRTVKPKGTSAERVSGTGGVKRPHSPGRSFANLATGRGENQAGLEARLAALESMLRDVPPNVHNAFLSTLDARLGSGTGVGIKEGGSGGEGVGVAAEALGGTTTNLSELVGMSTGYTPALSPYDQQNKLAADWGLNSSGGPDLNGWLGAGLGKKKEEVGMDELAKKLGGMSFFYEDEIGQAKWQGATSGFPLLHLLAAHNASKEDDDEGAGEQEILTSPAAESTLSTSPNNPHLSRRVSSASTALNRTSTAQPKRSQSIGLGAIGRRASSMEGKRKERFFPDRTPRPHQTLNPEASWKVITGVIPPDLMDTLVRCYLSTSHLLWPFLHVPSFLADYANPAQWGEPGFTCFIVAVCTLSSRHVDDPRVRANPNDPSTAGKQYFELFKRLRDLPSADRPTLYSIQAAFLAAIYAFGLGNLSKAFALQAESITLCLDGGLHRSVDAYDHFDAVEKETRKRTFWSIYSWDKQSAALFGRPPIIHLRDCDVTEPIIVDDENLVPEGIKDDAINPKSRMCAFVATIRLHVILEGVIDSATSPSAFPTSPFLARAAATIARRMPQTETLRAEEELLEEWKRILPKYWNYDTDTANSRDPIRITQAERLHCLEHLVKMIIYRHRFSGFVAIPACTPEERTRHLDLCKKAMQCALTIIADHVHISQRGMMTYYGVHVIHQLAQAGRTLVAVILNCRNTDFRPIIAPSIEGLRSCVGLLRRFSGRYLCGLRSADIIDEFCRVCNIPVDSPRVPDSAGRPSPAWLRPVRKHIATTPPISDSPASSGMMNFDPNALHSTDSGRPSLGGLGGLGSSAPELEALFNTAAYFNVPGEQDVNPVASTRESGSGGFMPTLGGLGEASAPFDRFETLTPNASLGNGNAMLSGQDADSNNYTYNANASASDADQPMSEHQQQAGARAGNLSFDYGMNGQGFGGESLATAGMDNVSDGLKQGGSALSAATILSLMEEGSFDYGSVFTDQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2F8</accession>
    <name>A0A1E3K2F8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034807.1">
        <property type="nucleotide sequence ID" value="XM_019173081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2F8"/>
    <dbReference type="GeneID" id="30190122"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="299" mass="32689" checksum="0DB25590B82D8764" modified="2017-01-18" version="1">MFNVCFIVKLTGINEIRVSHIIQRDTSQNANTYTNRTAGASLAILMAAMARLGPVDDNHSMKATFARVNVGANEQDQAASSAAYRRPPPALLDGQVGSSDPVLSTESVVGLGDRDTIRIFDEDLGLVPPTSHFKALSALRPANDIPLTLPPDFRLKQVLTKPYAHHTPPLTSTASSVSHIQTLQFGTFIGTGALWDVYELPDAPGHVAKFCSPYGTLFHRGYEHLDVGDIVKERETDTLHSQILAPSGHAPVTLGLWRGFWVDPAHVTYDKGGEAKGWLMYVSIQEDMRQDGEWESVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2M1</accession>
    <name>A0A1E3K2M1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034733.1">
        <property type="nucleotide sequence ID" value="XM_019173007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2M1"/>
    <dbReference type="GeneID" id="30190048"/>
    <dbReference type="OrthoDB" id="2570109at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="345" mass="37479" checksum="91AD59383D032793" modified="2017-01-18" version="1">MGVFIKTVYNPLLSQPFISLALTSLTLLLLVLVLLSVPGPIKGMYWFSVQGEGDGPMSAGVLGWCMTDTSNCTYAPLSENAYLSTMIDTGEALTVRIMLPLACYWMIVVFVTWICLTIATPIGYRIRDLDSITRHLRFAVAEACVLCVSLFGNVLCWLAFGLGRAAYLSIERGGGKPKSGHAMETTAVAAVMSLLSLGTAVWGLHLRLKQAQSHWRDEAVMVRRRSMALFASGAVRPEDANALASLGMTEGAVEKRGSKRWSSSSEVPGYPQSSNGLQHRGSMVKATYSPETDPEALPAGEEEEQIDAKLAEARRNSMDQEMILRRQSVNDSPYAVANGTPRPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2R1</accession>
    <name>A0A1E3K2R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034778.1">
        <property type="nucleotide sequence ID" value="XM_019173052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2R1"/>
    <dbReference type="GeneID" id="30190093"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="422" mass="44925" checksum="9D78CADB70181115" modified="2017-01-18" version="1">MSQLQNIVIIGASNAGHNLANALQSTHPKSHRILLIDALEYSVWPLAALRAAVVPGWEDKITAPLRDTTVFAAGSQHKVIAPNRVVELREQSVVLEYPFESSVEVPFFRCVIATGASQPSPMRPPSSTTEDEFKQSLRKSQQQLAQSKKVVIIGGGTVGVEMAGEIRAVHPEIEITIIHPNKALLAPEPLPKTANDSTKSWTNPPTAPKLSKNLQTVLEGMNVKLILGDRAVIPEAGSVTDFAQWDGTAGPQSQVKKLSLQSGEQVEADYVFVSVGNKPNTQLVESVDQDAITSGLVAVDDYLKVASTTDSSPLSKNSNYYALGDVSAAPGPKTAYFAAEMAKVLAQSIVNEVNGKSPTQYNPGTFSVFFVPVGPNDGAGSLTLPYIGTCVVGGGMVKMAKGKDLLVGMSWKPLWQGSEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2T6</accession>
    <name>A0A1E3K2T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034806.1">
        <property type="nucleotide sequence ID" value="XM_019173080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2T6"/>
    <dbReference type="GeneID" id="30190121"/>
    <dbReference type="OrthoDB" id="2571149at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="34337" checksum="7D8AA3800CCC52DD" modified="2017-01-18" version="1">MSRSARYAAPSLRPLLPRHIDLSHIKPPRTKPPPAVPFFRDPQHTIPTKWSLYRPLLRFARGYLGDDTAYPSVGREVKRLWKSRRSWTSVPQVRTFLQGQYDILSAFQDNDISELDELEARLANNHRLHDDRIATKAALEAAKPRRPRPRIVGFLRPTLFNPPLPRLKPQPPHLGAMIHARLRRRERRMDRRKEYASLRPDMKLEVAFWKNVLGREGEHLTENTLSPGGWDQLLREEVEAMDARFVKENKRADMVYDETMYERIESAKKARSEWWTNKKAELKAERLEQKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2V6</accession>
    <name>A0A1E3K2V6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 30 (Zinc transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034828.1">
        <property type="nucleotide sequence ID" value="XM_019173102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2V6"/>
    <dbReference type="GeneID" id="30190143"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000024">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="311"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="389"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="54158" checksum="0B58FC9953C45FA9" modified="2017-01-18" version="1">MGLSRQARIKTLLAIDTLFFFIELITGYAVGSLALVADSFHMLNDVLSLVVALYTIKLATSPSSAANSYGWQRAEILGALINSVFLVALCVSIGLEAVGRIVTPPEISNAQLIVFVGSLGLLSNIVGLFLFHDHGHSHGGHSHGAIALPGGDVDANEETPLIRDDVSELYQHPAQTRAQVIETAQEFGYGSTQVASSFDSSAMGKSPLSAHGRAPSASRRSNRASISRPHGRMNSTTRPIPGQNADLLPVGAEVSSTGSSTVVDAGKPKDHSSASDHSHAGHSHAEGEHDHAHDHGKMAKNVDDAEAGHSHGHGHSHGSMNMRGVFLHVLGDALGNVGVIAAGLVIWFFEGRWTLYFDPGVSLVITCIIFSSALPLCKSASYILLQGVPSHVSLDAVRQSIVDVDGVDSVHELHIWQLSESTVVASVHVLIEHGKDYMEVASGIREKMHSHGIHSVTIQPEFYDEADTSAEACLIRCPPGDCEGDTCCPPASSSKPPSESGEVAHNHNHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K382</accession>
    <name>A0A1E3K382_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034968.1">
        <property type="nucleotide sequence ID" value="XM_019173242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K382"/>
    <dbReference type="GeneID" id="30190283"/>
    <dbReference type="OrthoDB" id="10315278at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="186" mass="21266" checksum="A99562BA3B363AB3" modified="2017-01-18" version="1">MRSPNSDMIVAQVYYARNAAVQADGRRPDEQQRYDYYSRVSAQAELLRQQQRQHTKPDATPTQPEAVTSFSQPNNPYSQTNTTEPSPTRQPDTRPSYRSRRSAQAIARLKELGYDPQSHVFPPPGWKHIPQTDRTGLNHVGYFPMVNNAGVPLQREKASKGKKREQESRAKVERQAWWINTTSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3D3</accession>
    <name>A0A1E3K3D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035018.1">
        <property type="nucleotide sequence ID" value="XM_019173292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3D3"/>
    <dbReference type="GeneID" id="30190333"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="305"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="419"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="46703" checksum="26EBBFD3D3E3EAFC" modified="2017-01-18" version="1">MAPSPEGVSVVLGAQWGDEGKGKLVDILAAEADICARCAGGNNAGHTIVVRNDKGEKTSYAFNLLPSGLINPTCTAYIGSGVVVHLPSLFNELDTLERKAGLKVAGRLFVSDRAHLVMGFHQIVDGLKEVELGGSSIGTTRKGIGPAYSSKASRSGLRVHHLFDPTFPTKFRKLVDGRFKRYGHFEFDTEGEIEAYLAFAERLRPLIVDGPTYMHKAISSGKRILVEGANALMLDLDYGTYPFVTSSSTSIGGVISGLGIPPFALKKVVGVIKAYTTRVGGGPFPTEQLNSVGETLQEVGAEYGTVTGRRRRCGWLDLVVMKYSTLINGYTSLNLTKLDVLDGFDEIKVATGYKIDGVEIEGFPADLDRLAQVEVQYTTLPGWKTDISSVKKYEDFPENAKKYIAFIDEYLGVKTQYVGVGPGRDQNVIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5P2</accession>
    <name>A0A1E3K5P2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035351.1">
        <property type="nucleotide sequence ID" value="XM_019172409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5P2"/>
    <dbReference type="GeneID" id="30189439"/>
    <dbReference type="OrthoDB" id="10367866at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="479" mass="51563" checksum="9E1DA34390436D00" modified="2017-01-18" version="1">MGTSLSRSSLATAYNGHSNTSHQPTSSLESLSSLLSSVHQSPTSSSSTSLSYKVTLHALPKLIQSVEEMKRVSVVAKVVGDLVAAPGGLDGEEKRLCDERGMESAVQEQDPAAREFLSGTDNIMPSPHLATSQHQSRAPQSPPFTLLSRPTTPCDDTSPAGHAHDPLQCSPPRALTSYTPRASIQRLQSLPTLPRLDMIDCDEEVAAITGTIMEKRSGKSLGGEGQERETRGHVFQVTSDCPDTIASGTNNTNKLPILVSPCPSISDPFHQRITVSSMLSQSDSLESLYSRYATMDGGRPMEESIHDTMPELEALDVKERAQGNVEAANVSETPKGTKPVVGFQHRQQEVMPDLDSSSSSPISPTVQTPKTPTRPFSALPIPVIIITPEIPASSSSEIDYFAYNARLSTRLSTSAFESPSKTGKGGSKRQGMLEVPKRETKIRGRKNVSSKKMREKSTRRKLGDESVVVQREAGASVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5V5</accession>
    <name>A0A1E3K5V5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035386.1">
        <property type="nucleotide sequence ID" value="XM_019172444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5V5"/>
    <dbReference type="GeneID" id="30189474"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="25646" checksum="2425CC3C97D5301E" modified="2017-01-18" version="1">MPPPELSALRLHRPPFATQTPVSGWPPLATVKPWHTEYTLVFVVDRTHSRFLLGHKKRGMGCGLYNGYGGKPEARETMLDCAIRELQACRVSNNHIRSNIIFRQEESGLVTNKNDIRLKGLLLTSRPTSSDNAVKSLLRIHIYECTSWSGDPIETEEMAPEWFTQDNLPLERMWPEARKYVPVVLDSILHGASSDLFLARVDYAYLTAESAPTALPPLHGQSVLLARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5V6</accession>
    <name>A0A1E3K5V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035252.1">
        <property type="nucleotide sequence ID" value="XM_019172310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5V6"/>
    <dbReference type="GeneID" id="30189338"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="598" mass="64193" checksum="74E55A3DBAA5AED0" modified="2017-01-18" version="1">MPALHQWDYLFAFGCIFAALDAYNIGANDVANSFATSISSRSLTLRQATCLAAICEFLGGVLAGAQVAGTIKNGIISMSAFKNNAGMELLGFVCALVASATWLMIATRKSWPVSTTYSIVSALAGIGVALDGPGAVQWGWNGGNGLATIFAGFIIGPGISAAFGATVYLLTKYAVLKRKDPVRAGLRAAPVYFFGVAAILTMSIVYKGAPQLKLNQLPQTTIALAIVLTGLVIAALAILFWMPFVHAKVIKKDYTLRWYHFFYGPALWWRAAPPAPPSGQEMAHVPDYRVYDRDDQHPAESAKPTTSPEAVRPTSVTLSDNDHTSSPDGEKSISQDKERDLEANVAPLASEKKVYGSKLEELEADEHKLEGNLLSPKNLWILFRYRLPRALLHGTSVDIHAMQSHKGQGKQSDRMMAMYAQAAQYDNETEHLFSFMQVMTACTNSFAHGSNDLANAVGPFAAIYYVWSEGVVTPTDTETPIWIFVGGGLMLVLGLATYGYNIMAVLGNRLTMHSPSRGFSMELGSSITVLLASQYGIPVSSTMCITGATAGVGIVSGGVKSLNWRAFGWIFLGWVLTVPIAGTAAGCLCGIIMNAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5X7</accession>
    <name>A0A1E3K5X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport through interaction with t-SNAREs 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035328.1">
        <property type="nucleotide sequence ID" value="XM_019172386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5X7"/>
    <dbReference type="GeneID" id="30189416"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="26110" checksum="77ED8515C8A6145B" modified="2017-01-18" version="1">MDNSPTALFENYDEDLKQLLGGLKAKLDGEVKGLTGEQRKAALKKVSEEIDEAEEIVGQMEVELPSMPVSIRSTYQGRLATSKQGLDKVKKTLRDLRFESQRSELLSGPGGAGQSGRCPHADDPYSDDPEPYSTRSRLLQGTQTLEDSSGRLDNAHRIALETEGVGSEILRNLRGQREQLENTRDTLTQADSSIDRAAGTLKKMIFKMYQQKFLSIGIIIVLVLLILLVLYSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Y6</accession>
    <name>A0A1E3K5Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035356.1">
        <property type="nucleotide sequence ID" value="XM_019172414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Y6"/>
    <dbReference type="GeneID" id="30189444"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="150" mass="16847" checksum="4FDAA02BBCC81226" modified="2017-01-18" version="1">MRVDRCDFSGYKVYPSRGKVYVRGDSKTFRFLNSKNESLFLQRKNPRKIAWTQVYRRMHKKGITEEVAKKRSRKNVKVQRGIVGADLASILAKRTAKPEVRAAARQAAITKAKTEKRDKETRKAANKPTQSNAPKVSKQAAKGGAGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6E5</accession>
    <name>A0A1E3K6E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035613.1">
        <property type="nucleotide sequence ID" value="XM_019172671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6E5"/>
    <dbReference type="GeneID" id="30189704"/>
    <dbReference type="OrthoDB" id="2575819at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="731" mass="69898" checksum="67BD3027EFFE7134" modified="2017-01-18" version="1">MSSTIKNVERKIENTLSSGQPGTTGREPFEDSSTSIGGNNTSSTTGTGQQYGSGTSTHGLGNTSSLGQGQTGGAYGSSGQSGLGQTTSSGYGGDKVTGIDSQHNQGVGAGSTGLHSRTGTGQHSSTGAGLGHSTSGVTGDRSTGPTGLHSGSGVGPNTTSGSGLGHTSSTGQTDSTTSGSHHGTGTGLGAGAAASGAAYEAQKLGKHNTSDTAAGTRDVSGSSGAHGYNAQSSNVSGHGLTGDKTHSSTHGSNTHGSGNQSSAGNVAREAEREGSNAHHSGAGKNAAVGTAAGAAGGAAIGHHASNTHSNSAGDRSTTSSDPTSTQAPEQSHEGGGSNGLGTHAADCSGGPHDSTHHKVLPGNQPGSGHTGQGVSGGTRTAGEGVSTDKVGKQGQNAAAYERSTTEGPVTGGAANADRFDTDKSSSSHGGVKGAAVGAAAGAAGGAATGHHSGSHNQSGLTGSGAGKTHNYDGTTGSHSGLSGSEDPNKQQSGGAKGVFTTSDKDFTNNERLGKGAYEDSNAAVQNNTSGPGGNPALTGREGNSRTNPVSGETGLSNTSSSHTSGHHGKATGAGAGGAAGGTAYEANKHLGNHGSSTDSSNLPEQQSFNKSSSAHGSSSVPGQQSSTGSSVPGQHPSSTTASSAGGAHDSAGHRAGVVGGDGTTATNASSGYGQGAQTGQYTGTQSTGSTAPSTGATSTSGHSTTAQNVETAAEDSTQKKGLLEKVKGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6N0</accession>
    <name>A0A1E3K6N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Etoposide-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035655.1">
        <property type="nucleotide sequence ID" value="XM_019172713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6N0"/>
    <dbReference type="GeneID" id="30189746"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="31304" checksum="5C887B0AB1018D86" modified="2017-01-18" version="1">MEARTKEIGLWYNVLLSWPVFVLCFWVNAIWGPRISRRAQTMLHPTYRHQPSPASTPIRSRPAPSPTNGILANVFSSVARILLISDFTLVSRLIGLLPGVGKLGAFAYMCVVDSYYCFEWNFSMKQWPLEYRITYIQDRLAYMFGFGLPATLMTSFGPPLVTMAIFALIYPLFVIQALQSRPPTRQSSLLPSTPTGSIPPSPGAYSPGPSPTAGFTFPPPSSPAFSLAKLVNVRPRLPLFWFARHALEGLKWLEEAVGRDRSGSGKGVVGLGIRERPGKRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K727</accession>
    <name>A0A1E3K727_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035518.1">
        <property type="nucleotide sequence ID" value="XM_019172576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K727"/>
    <dbReference type="GeneID" id="30189608"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="457" mass="47413" checksum="B09928A9522D5E52" modified="2017-01-18" version="1">MTTTGSDLRLVSSPTIGGLHDGTNTQVYTNADMKNQATVWAGELHKVNGAWHIYYSHKERIWAIKGGDNPLDEYADPVQLYDHFGIDNTVLAHNDNNYLLWACHSTDVSNNTIAGSSMCISHLTTPTSINKDEISVISRPTEAWEQVGGHVNEGAQPLYWDGEIYVTYSASFCTKPDYSLGLLHLIGDDPMDPAAWSKVTDGPVFSSGNGEYGPGHNGIFTSPDGTELWNVYHAVTNANGSCGMDRQTFVEKVDVSQFTSKGPIFGTPAKKGVVAEGPSGEGNNTGQSSSSALSATSAATRSSSASSNAASSSDATPTISLTTSSIVASTALSLTASLSTTESSGESPTASSSASSEEEDEASTSSHSRGGHHTTQSGDGGIALIASGSESASSLDSSSRTTVTVGQGEVTRTTTLFVTAKTSQALAAEVTSTLGTGGLSCKAKRARVAEAASLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7D0</accession>
    <name>A0A1E3K7D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035760.1">
        <property type="nucleotide sequence ID" value="XM_019172818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7D0"/>
    <dbReference type="GeneID" id="30189857"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31420" checksum="5FC97C7341D94B99" modified="2017-01-18" version="1">MPHISLTRPSLNTWLLTLSSPPDNLLSASALQDLSEALDVVEYEWLARSPTSSASSTQLKKEDNAKKANIKGAGAGALVLTGEGRSFSAGIDHLALFQLAKQGGDPDSFFPKVFDPVLWRLMTFPLYTVAAINGHAIAAGMILALACDHRIMTSGKGFLSMNEITLGTTLPSSFASVLSTAFPSHRDLRDTVAGKRWVQKDLLKLGLVDEVSTPGGLLKRSGEIGQQEGVKVALGNWGRIKQSTLEPILNLPPANLLVPKTLPSFVAQLSQERRQQVEMRVRQRMRGGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7I1</accession>
    <name>A0A1E3K7I1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035668.1">
        <property type="nucleotide sequence ID" value="XM_019172726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7I1"/>
    <dbReference type="GeneID" id="30189759"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="49"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="593" mass="65256" checksum="773F6F6F0FDF34FC" modified="2017-01-18" version="1">MVLGLSTWWGGVQKNEHKLAEQAKPEVKRKRRRAEPSSVVPSGSKEHFPGMVNLSGTLCYMNSVLQSTASLSSIISHLEHVIDLAVEADMPTHVADALLEVVRELNTPHKSHPPALRPHGLLQALYPLPAVRRLLGTGEQQDAHELFLVLAEAISDEVVKVAIEIAKLRGLGDLLPLQGYAAGNGGGQPWEGLLARRRVCQRCGWSETVRLETLSGMELPVPLHGDTTLDACISLYLAPEQLTDVTCEMCSLEVTLQHYVMEVERLSMPASEASQKPRSKAKLDSKGDEPVKSGSFSALENSPTPTGGEAQEMTASRRKRARDARRAETRLREMLESKTVSNFGEPSLVPLPSSGSTAPISVKWLTARTSSTRQAVVTRPPQTLRLHFIRSEFTMYGTVQKKIARVAFPMVLDLTRFVANGVWEDMSGVKNMLAAMGGQNDPSAPVERRVLYRLESAILHYGFTHSSGHFICIRRKPSTPSATAEDHSLRPSVASRSCPEGCKCEDCILFGPVRDPQPSGPGKGWLMISDADVEEVGEEALNEVRGSVVMLFYERIAEYSGQKTSVKERKTEEVGEKTRIDQREPEEETRMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8P7</accession>
    <name>A0A1E3K8P7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035468.1">
        <property type="nucleotide sequence ID" value="XM_019172526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8P7"/>
    <dbReference type="GeneID" id="30189557"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="313" mass="34281" checksum="89100095D3C80A15" modified="2017-01-18" version="1">MPTLSKFVPGLALRLRPQLASPRATRLARHLTQHALHPHTHQAHHAPSQGPSLFKKWGTRLLIALALPVVYVAGAAFPPSIVLMILPRYAPPAPVKDSPSGRAHTEDVERSLQELEVVQNMRYEIKKGADWYETRPYNNYDPQKIHNSLTAGSLRGPGKLAVPPILFAKHDESEAIAIVHLGRSLCGHDGIIHGGLLATVLDETLGRNALLNLPSRIGVTANLNLNYRSPCMADQFVIVRTSLKELKGRKAVVEAKMETLHGDRIVDATALFIEPKWAQFLASSGVTEAMGRPIPRPANTPALMDGSETERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9G8</accession>
    <name>A0A1E3K9G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stress-induced-phosphoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035747.1">
        <property type="nucleotide sequence ID" value="XM_019172805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9G8"/>
    <dbReference type="GeneID" id="30189844"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="467"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="64134" checksum="7B42ABAA67C4876E" modified="2017-01-18" version="1">MSDAVALKAEANKAFAAKDYPSAVKLYSDAIALDPSNHVLYSNRSASKASLKEYDGALEDAEKTIELNPSFSKGYARKGAALHGLRRFPDAVMAYESGLQAEPNNSPCTKGLADVKRAMDTDSASPFGPQGGDMGLGKIFSDPGMIGKLESHPKTKEYMKDSTFRANMLKLQATGGGDLSSLMADPRTLGALGVLMGVDIDAMERPEGSNEMPPGVSTPSAPTPAPKPKPAPTPKPKEPEPEPMEVEETEEDKQKKEAEALKAQGNISYKARKFEEAIEAYSKAWDLYPKDVTFLTNLSAVYFEQGEYAKSIETCEKAVEEGRDLRADFKVIAKAFGRIGTCHAKQGDLASAIKYYQKSLTEHRTPDILTKLREAEKAKAEADKQAYISPELAEKAREEGNEAFKRGEFAEAQKSYTEAIKRLPTDPRAYNNRAACYTKLLALPEALKDAESAISIDPTFIKAYIRKALVQETLKEYTKALDTLQKATEADVEKKHTRELETNMAKVMREIQSQRSEESEEQTYERAMRDPEVAQIMSDPIMRQILQDAQQNPRALNDHMKNPMIAGKIQKLVNAGIIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HAA7</accession>
    <name>A0A1E3HAA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000075">
        <property type="protein sequence ID" value="ODN73085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019180280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HAA7"/>
    <dbReference type="GeneID" id="30197525"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="112" mass="11870" checksum="96715B7DC3D27201" modified="2017-01-18" version="1" fragment="single">MSPPDDKPADTAPGAPKFISIFYDEDDNPLDTTAAAGRPVLRLDKAGKIILSPVPPIADMTVPLQSDDKSTSYPGHQLPPHLLSGPTPRAPASESQTSSQDSLRLSDLQVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ34</accession>
    <name>A0A1E3HJ34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027949.1">
        <property type="nucleotide sequence ID" value="XM_019180095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ34"/>
    <dbReference type="GeneID" id="30197335"/>
    <dbReference type="OrthoDB" id="2526823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN76348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="497" mass="54604" checksum="A660A7BBD928942A" modified="2017-01-18" version="1" fragment="single">MTAPGSYPTRSKQPSLTPALDDAWVSENESELSVPVSTPSRPRTPRRRAVKSTPTRQQPIQTRSPVKKGSMSSNVVRPRNKLDDVQRPRSPTIPSPSSPPIQTPPAPDLLSSLPSLESTLRYVFAPIRILMVPINMAASPFIAHFVNALILAALAWTAWVLVVPLLPGLLWRLLRGVMGGVMGLGSDGELGISGELVRLPLATLATPTCALTGLFCRHSLFTISSPHSSSSTDSQSSRQLSTQQARPFWLWFSSTTPKDEVDVGEAARVLTKEVQRARDIFDSVRLVGEESVAPMEYVNRVWELGSALMVRGRVDAQSHKLGTMVIELGDDCRDLVDEISYIDSKSVNDFGWIQWEFERLVHLLSSPTVSPSPTVLGAKVHSLLLSLSSTLDDLHSLTSKAAQHANIASTKGRKIGTEMKTIEGALRVEEGREPGWKRYKDKGQKFFLGGEPTRGEILARDISLTTQTIVTTENLVRNLEATRSVIRSFRDQIGMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJN8</accession>
    <name>A0A1E3HJN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027946.1">
        <property type="nucleotide sequence ID" value="XM_019180092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJN8"/>
    <dbReference type="GeneID" id="30197332"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="142"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="38504" checksum="7078009458B476C0" modified="2017-01-18" version="1">MALSQKLKYAVLGVGRMGQRHALNLAHRTPRAELVAIADPKPASLHWATDSLSTSVGLYTDFEQCLAESGADAVLIASETKLHAPMTIAALHAGKHVLVEKPISIDLQTSRDVVEETKKFPDLKVMVGFSRRFDESYREAYKMINTGKLGKPHLIKSATNDQYDPSGFFAASTLTAAYDIDCARWLLSTSSIPNPLKQVTRVFASGHNIRHPELVKDNDVDNAVGFVEFENGGILMLHLSRTAMHGHDCFAEVFGTDGKVIINGNPQLNRVEIRDVHGVRSESTPTYYERFKDAFVLEVNEFTDAVLDNKPLPVNSLDALEAAKIATALTHSFRSGQPVYFSDEGEPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP19</accession>
    <name>A0A1E3HP19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IPO4/5-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07996</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028030.1">
        <property type="nucleotide sequence ID" value="XM_019179969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP19"/>
    <dbReference type="GeneID" id="30197207"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="9">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="896" mass="99403" checksum="752CF8F56918D926" modified="2017-01-18" version="1">MSTEHLLGDIGAILSALNGIANEPRREAELHLQKLTVEQPAEVLLLLAQIGALAVGGFQLDERFLSLILLKSLAFKPLPGLYLNSQHQLPSAPFDVIRETTRGRIETVLCAGLKDELDPRIRKGLGMCSASWAEESHKRKRPARPFVPVCLELTQSPNAFHRFTSFQLLGYTPTLVDDAADGPLSSSQLTALLLTGLEDSSVDVRLEAIKATKSLLIRALTHEARDEVGEVLIQASFQTLQNLPQDLVPIGLIPLVELASIHPKLFISSLSLIITKLLPLLSPPSQGRNLPPYAFSPYPAHDMTLEAWEAFANPATELLLSLAEMRPNEFEEFENGRALSEMVGLLLGREVATFEMDCQEWMEEEDLDEEDVNYPVFPEEALDRLSVAASYTDESMEIIYSSLLKHVQALLQQEDWRCRFAALMGVGCVAEAFGDAIVDRDILSQVFALPKITDYGRDTLHIILHLLDDPVMRVRVHAAASLTTFFEGEEHPEIVGEVLDRIVRGCVGLYEAGPMYAKDQALATLGTVAMAAKDMFRPYYRNLMDLCFQIMSAQLGASKEERVVQGGAIECGYMLAIALGGTNPGDALKFVQLLLSIQNTIVDEDDPRSRHLMDAWEHMCDSLGQQFAPFLQYVIPPLLKTAFYRPQKASPNADDEDDPYWGDELSDKAEAFKHLGFYASKMRESFAPWLAQSMGLCLEELNHPYAESVKNVAAYLVPALLAVAKESGAWNTNPENYVQAFRQLIKAMVNALDISVISILFKSFKDALRVVHTPFPPDLTRRLLKASTAIVYNLAQARADRKEQEPYMDETDHEYWIEEQLEEDQCLKRIEEAVDGIVIVGGSEEGQAMGALSGGIENDILGLKALIRKVGAQKLETKGYDDDDDDNETLRGDQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRW7</accession>
    <name>A0A1E3HRW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028085.1">
        <property type="nucleotide sequence ID" value="XM_019179909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRW7"/>
    <dbReference type="GeneID" id="30197141"/>
    <dbReference type="OrthoDB" id="2930561at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="265" mass="28310" checksum="2DEE9A75C3F8CFB9" modified="2017-01-18" version="1">MSSTTPPLSRAASYSIPATPTEALQTPSTGTTVDLTQRQSQYDASQVSGQADPPKVAKYCVWSDADDSTMLGVLTDAKIDGQTSDNGFKASVWTRVINAVNPPTSGNPKTLRSAKDRHAHLSRDWAVMRDLRFKSTSGWGWDDENCMVTAPDEVWDRYLEAHPGHKKYRDKHFPLYDQYEFLLSDVGATGANVVTAGDPPSPVESTSTVPSVAEIMGERQATEGTAGGSLEEIPSSSRSGDAPPTAHGTPSSSRSGDAPPTAHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUR1</accession>
    <name>A0A1E3HUR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028167.1">
        <property type="nucleotide sequence ID" value="XM_019179863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUR1"/>
    <dbReference type="GeneID" id="30197093"/>
    <dbReference type="OrthoDB" id="10366665at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="23518" checksum="118964AF54DA3ECC" modified="2017-01-18" version="1">MSARRAATPAPMPLPLPTPPVDAAVKDPEQDLVPSLHQSPPIQDSDITDVLGRPIRRESLNACADRMIMGGEQESERVKPGFTIMSIPTVSEPSAVKLASTRPAPAFFPTPAAPTSDSSILSSLSSATTETTLASTATAYDVDPKRSPLEVFTNAQFHSSADIELGVQHYNKVAPSGIKEKRENCMKAPRWIAYAAASLFLVAIIGGCTYALVHHVKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVF1</accession>
    <name>A0A1E3HVF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028208.1">
        <property type="nucleotide sequence ID" value="XM_019179786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVF1"/>
    <dbReference type="GeneID" id="30197013"/>
    <dbReference type="OrthoDB" id="2597010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="346"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="577" mass="65380" checksum="F808347AC8D7F012" modified="2017-01-18" version="1">MGKTLARLIPFFAYFYHYKFTPGYHNILDLAARPDPDPDAGREKFQVTTSTKLGIERKFHITLRDLFMLFYVLLHNDIKVKVNPSDDKTSVQVSEKVQGMLSAALIAILAQLAQEFHVNRCEFINLAIHDFSVTFQLKNRNIAHVSRIVFRDPATAKRDILSEGELTNILSGIQSKTKRTAAVQMLLREKPWETEAQHSLFAVHVAGLVLPVGEDTTSMWMDGENEDLGQVEDATGPVSEVPPQQHRGTSAFKMIPYPAVAADLQLHQSVDTTHHLAMKRLSDFRWEEDSTFRVQVSPPLTTDESVVSTTGNEKSSRQEPEDLNELLRKTDHQTVLSLLSHPDLSVELLQYIGSGRLWDAYRVKLSSGSTPPQIVVAKICNLYTFMLGDANKYETPSAAAEAIKIELDLLNRLQAVQGEIVPRLYGRWTGRRQLPNGGMTRLECVMLEDCGMPFAQSDKLETESVRLLIPSLDLGKSLIVFDPRLYYDDKVERFTTDLSSNVRQQIIESYERLHKQGILHVDVNKRHILLHPVDNKPRIISFEGAISVSEAQASYPDYNAEAEMERVRWMVRADEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY91</accession>
    <name>A0A1E3HY91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028245.1">
        <property type="nucleotide sequence ID" value="XM_019179764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY91"/>
    <dbReference type="GeneID" id="30196989"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="25138" checksum="06365B3AF121846F" modified="2017-01-18" version="1">MTMSSCPWPTLVLPLLAQRLPFPQRAFGGPLLNVLAQDVRARACVQECGGCTGGRARTIGTSCPGGRRTFRGIRGDHWLGIAVCSDGLWVYFGKVWTTERAGFDSSDVDKNGKIEEESSFCSSTSWIIVALLAAPDVVLCGPSPIGCCAKLGKLVHTPDVEGIGIELPLTTGSSLGSVRIGGVGGDNADDDAREDGRPEATTMLRALEKSRSLTTASLSGQGLVVCSDGPSVVWSGRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I148</accession>
    <name>A0A1E3I148_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028277.1">
        <property type="nucleotide sequence ID" value="XM_019179730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I148"/>
    <dbReference type="GeneID" id="30196953"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="328" mass="37405" checksum="6A03BEE5B7AE30E9" modified="2017-01-18" version="1">MAPFDLDACIDRLRNKQLLGEALIREICEKTKEVLMRESNVVHVSSPVTVVGDIHGQFHDLIEIFRIGGQAPNTNYLFLGDYVDRGLHSVETISLLTCLKLRYPERIQLIRGNHESRAVTQTYGFYLECTRKYGSPAVWQYFTDMFDFLTLSVVIDDAIFCVHGGLSPSIHQIDQIKIIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGASIVKKFLHLNGMNHVLRAHQLCMEGYSVLYNDQLSTVWSAPNYCYRCGNMASILEVSPGGRRFFNVFSAAPENEVCQVIAWIMIQLIDSFSEMDRVSSSQERQQIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I170</accession>
    <name>A0A1E3I170_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028272.1">
        <property type="nucleotide sequence ID" value="XM_019179725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I170"/>
    <dbReference type="GeneID" id="30196948"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11999" checksum="9544F4864C4F8B51" modified="2017-01-18" version="1">MSTITAGRPVSKSEWGHFHRLEGVKTSIVIEPATDRTGEVSLFVMKNKSHHNAFCKACVKAKKEILEDTIEVVEVSEDEDEDGSETGEKDKSDEEQDEEMNLDGAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I177</accession>
    <name>A0A1E3I177_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="11" type="ORF">L198_07747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028282.1">
        <property type="nucleotide sequence ID" value="XM_019179735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I177"/>
    <dbReference type="GeneID" id="30196958"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="35988" checksum="0A422969631FECC5" modified="2017-01-18" version="1">MIATQAAIPVPVPAPSPVPLKPSSTVLPATVPENAPDHCPGVESTNAGKSDACEGCPNQSVCAEGPKGPDPDLPLIRERMSNVKRKVLVLSGKGGVGKSTFSAGLSWALAADEECQTGIMDIDICGPSIPLLMGLQSSTIHTSSSGWSPAYALDNLAVMSIGFLLPSTSDAVIWRGPKKNGLIKQFLKDVEWGDLDYMVIDTPPGTSDEHLSIVQYLKEAGIDGAVLVTTPQEVALQDVRKEIDFCRKVGIPILGMVENMSGFVCPNCKNESQIFAPTTGGAEAMGKELGIEILGKVPLDPRIGMTCDEGLSFLDEYPDSPATTAYLDIVQRIREILGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1R1</accession>
    <name>A0A1E3I1R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lectin, mannose-binding 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028306.1">
        <property type="nucleotide sequence ID" value="XM_019179689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1R1"/>
    <dbReference type="GeneID" id="30196912"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129495" evidence="7">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="329" mass="36660" checksum="462B0D7792801EC4" modified="2017-01-18" version="1">MLPRLATFSVAFLALLSPTLAAKEPEDSLIGVIERTVPLRTHSLAAPYVDSDLQNRWWDFGGDTIINTMKHARLTQDRPSQQGWLWARMPLSVANWQIDVDFKVDGKANNIFGDGFAMWVSQDRAKTGPVFGSVNFFKGLGIFFDTYANTKHGYSWPRVSAMLGDGKTGYNQDTDNEANELAGCSENFRRRNDVPTKARLTYIKGKVLQLKLQTRKVDEWKICFETNVDLPESPYIGFSAATGDVSDNHDIISVSTHSVTVKPEHRDIKQALGADANKSGKGRKAEKASGGGAGWFMFILKFIGVLAFIAFGVAAFRTYNAQKRSKRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5G7</accession>
    <name>A0A1E3I5G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028389.1">
        <property type="nucleotide sequence ID" value="XM_019179621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5G7"/>
    <dbReference type="GeneID" id="30196842"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="32" mass="3966" checksum="0B4923BAD02859C5" modified="2017-01-18" version="1">MLVKEIREVMLLGDEKFARLRMVRWTRSTRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I7Z7</accession>
    <name>A0A1E3I7Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028396.1">
        <property type="nucleotide sequence ID" value="XM_019179628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I7Z7"/>
    <dbReference type="GeneID" id="30196849"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="35170" checksum="A689C684ECCBA109" modified="2017-01-18" version="1">MTIRILTLCGFTQNAYIYSKQVGAVRKACKNTEFVFVDPPIVVEKADLPWVNESNLDQFGSSASMDAENQTAETTPRAWWINADNWKTYKGFDDSVKFLHDYMVEHGPFDGVVGFSQGAGMAALLAALAGIEKPGINPLFPAHENIPRLKFAIFIGGFLPGYEPKCESHDFSNYFPLPASLPTLHISGKNDTLIVPERSQILASRCENARFELHDGGHYTPSKASWRHFLNAYINSFAPGGANGDLPDIDSYGPNGANAPASGGGKGSKSGSNTPTPKTPKQPKQPKEAKPVEGAKVGEATEKEVKEVKGDGKVAEIEEKAAGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9A6</accession>
    <name>A0A1E3I9A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_07608</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028455.1">
        <property type="nucleotide sequence ID" value="XM_019179598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9A6"/>
    <dbReference type="GeneID" id="30196819"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="395"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="658"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="864" mass="96002" checksum="7999A766C77A750A" modified="2017-01-18" version="1">MDGQEAIAIGILIAYFGLIGLSFALVSRSIIAGTETLKLWEGRAFYFLRSAFGALLCTWYFYERKLLDWSYEDFKASRTLTGDATFGQWLVNTALFEQAWTIVCKGAGNWWWSSWICTWTILFTVIVWSESGRRGIKYAYAYMLLGQLVAMSVATALFLVALSLHPRTSSNPRKIPFIIAIPLTLAFVSAWLLPQHVGTERFMNSLLWLHGALLLPLISPAKSGPDGQVESNGVPLSLLYPVIIGLMGFIHIPATQELFLRLPTSRTFSSHLLQVLFSHPAQASVSLDVVWVALVVTSWFVITGPTALRIAKAALVGIVGALFTARYLGVNWTLIASIIPIFFLLSAGGATLYIQNLRRTNLYKRQSLMDSMGMPDGTLVQGTGSKPPGFSSQKTVVGFWHPFCNAGGGGERVLWVAIRHIQKTDKETMVLVYSGDYPEASKEEIIGKVKERFSIFLDPSRLHFIPLRSRYLVSDGYWKHFTLLSQSLGSILLAWEGLCGKDDADLIADSMGYGLTYPTVRLIAGPDIAIGSYTHYPTVSANMVKRVKERVYGVENAGASKSWIKTQIKLIYYYIFTSIYSVSLLYAQHIMTNSSWTQAHIQSLLTSAPSSFLASILLKDEVSVQKQKERGELAEGEGLECGVVYPPTDTTELARLGGLESRKREIVSLAQFRPEKDHAKQLYALSAMFEKYPQYRHGSQRVTLALMGGVRDAGDQARLDGLKTLAKKLEIDENVEFVISAPYPEIVKRLGQASLGINTMMDEHFGINVVEFMAAGLIPLVHASAGPLMDIVVPYNGQRTGFHATDAASFAEAIHAALSVSPKESLKMRKAARQLAVEKFSERKFEEDWDVGYERLREIAWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA37</accession>
    <name>A0A1E3IA37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028463.1">
        <property type="nucleotide sequence ID" value="XM_019179517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA37"/>
    <dbReference type="GeneID" id="30196734"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15134" checksum="D08A55AB04B53B96" modified="2017-01-18" version="1">MLVNPWLYRPQWYYNNVYPAYPVIPPFAPIAPVAPVASVAPIAPVYPATRPVPINQPVIQETVAYQDRQPSYNHTTVVVKPGSGHRKTVSFGGVGGGKYHGQGQYGKGGGSYGHGHGHGQRNSYSENGKGRRAASSYTAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB98</accession>
    <name>A0A1E3IB98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_07461</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028598.1">
        <property type="nucleotide sequence ID" value="XM_019179457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB98"/>
    <dbReference type="GeneID" id="30196672"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="815"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN85893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="913" mass="98939" checksum="5C0DE5AD4FE59FCC" modified="2017-01-18" version="1">MGISGLLPLLKEVQVNGHISNFKGKKMAVDGYVWLHRGAFGCAEALVKGKRTTKFVDYALHRVRILRHHGVEPFIVLDGGPLPAKRGTEVSRARSRADNLDKAKALEAQGRHKEARDAYTKCVDITPEMAYQLIKALRAENVDYVVAPYEADAQLCFLEREGYVDGIITEDSDLLVFGCRQVVFKLDSNGDCVWIQRDRLATCREFPMHGWTDVQFRRMAMLSGCDYLDSIPGIGLKKAHRLMRRFASVEKIIQHLRLEGSLVPQTYAADFALAELAFLHQRVFHPELCKLVPLNPLPEAGLGEEGERWVGEDIEEGVARGMARGDVNPETRVEIVDEWPDFKPEKNGNGKVGGGGRGGGGKKGTLDGFVQRVKRPTVLPRPIGAFGSGASRLSDQIPISSLDSIPTTSSEDLDQPPAGRKSKFFSKKESTPELGVKLLWEDDSEDEAQLQSSMMIDTQRAGTRSPSPAVSSLKAGSSPARLVEEDDEREDEDDGEDGRLSETKSPSVMAISSPPCSSPLIPKIDKLAARSFPRNKAAGGVVKREKEESGLFTPKAGLGSRGDSFGSEYDAMEERKRGRGTLRVSRVLEPTASRDTIVPASSSPPLPQSEPSPAPPITSKPLSRQPPRRRSDLPSSDSIDSEELATPSHSHEPTSSQKKRKRSKVVEVEEEEMDKVEVERKEKAKVLAGGWRMKYAFGGQSSASPPEGEATPKPRGRGSIGIARPASTPLPAIAATKSGIMTNGFGQGSVMRTKMVDGVKMTKTNSSSSSTSTTFTENQTSETTLVPTSLPAKKPIVVPSFGTASTSRAKALKDDAVFKPWPDNVDTPTRGGGSGGKRDVKIGLGSVVRKTEEQGQGEEQNGGGEGRRDEDEDIGSFTPSPERGPGTGEKGVKVAGSTISRLEKYKFGMGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICH9</accession>
    <name>A0A1E3ICH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028684.1">
        <property type="nucleotide sequence ID" value="XM_019179328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICH9"/>
    <dbReference type="GeneID" id="30196536"/>
    <dbReference type="OrthoDB" id="2567960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="420"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127033" checksum="78ADE588210AEAB1" modified="2017-01-18" version="1">MEPTSDFRAPLNIQHLLRHLIPDDSQTKFLEGLQMASVRLGRETRIDERVTALMEAHMNKVFNQFIMQGFLAQYNPEGSNQSFRMNLQQAIEESNAAHREGNNFFYADPSSENTKIFSTVWEKVRCHQRSMGELKLVTGTDLKLYRTYEDCMILGKVITPVKSGLCLSFHIEDSCGAVFPVVIRFPTAVPHFSLSLPDTLAKLYPIGAILVIKSPRTGYIGGQRGITVDMPYEIEELHPNDPFLEGVKWQDGLKGDAPKGWKKYKDAGNAEMRKNNPLVAIRLYSLALSDPEVKSSPSKTFTLLLNRSKAYSTLNLHGHAYRDAHRAQAVIKTSSTTLTLGEQDRLQLQLAKAALGLRLYQTALDACGEASSEEEIRKTRERAQKRMEEQKSGVYDWMAIFRESLGGPLVDMDVGDYVSPAVKVSQVPGCGRGLIATQDITPGELIIVSKAIAPSRAKVDAPNVYVNCYDVGSQTHVPHETYMWVYRAQYKLHDEPVQLEDLASFSTDIHPSPPDDRTFDEEEDVRAECIFDSIGDGDIPYLPLNNFRQILKSNSFSGWSLPPKGEGLKGVDPLLMLKRYQDQADLLHGMPALLNHSCLPNTTRCWYGDMMVVRATKHISKGDELTTSYVAYEPSYSFRLSVLTNWNFTCACTLCQADSSPRDDPQRRDQIMDANMILLFTNPSLIGKPDRTQKQQQRRRAEDLEKLVRSVEATYSSERGQGTKGHLAKIYYSMGRSYFVSGQHPEAVKALNHFLEYAGVTLTTPAQERQTGRKVHESHYLEDEVIVGMLLLASMERVKALISHLPQALLLPLSQKCTTGAAGTSASSLNPALHHTRSVDKASSAPTATQSETPVAGPSLGDKGKERQDANADSTAQAAPVSPTPAQLSPAPTTGNFLASINITPLGDAPGPTLPQTPIASAPPEHAAADTTPAPTLLLARFAEMLKASQATAPLLDPTSKPPGLEDPAYPGTASANDTPPAKPLPPYDELYDVSCQLNQPSEERDHLFEALQQAQAELARMRTACLPQFGCRPDYTLTPHMSHHSTRLKPSGLPKLKGTSHKKVDPWIAQISALLCSATVTKSDVISFLPRAFKDRAMSWYVNLGPAKQLALVTWSDWQEAIRRQFLRANYAMKAQVECTHRQPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICJ3</accession>
    <name>A0A1E3ICJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Scamp-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028492.1">
        <property type="nucleotide sequence ID" value="XM_019179546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICJ3"/>
    <dbReference type="GeneID" id="30196764"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33290" checksum="534F745F62BEADD3" modified="2017-01-18" version="1">MSYNQADPFADNTAHATLDTDPFADSTKDPFTAQPNESLASFGGASGSTTNAYGDYGYGGGYTAGAGANQKADELRKREEELARREQEFERRQQETGTYANNWPPLYPFVHYDPSIIQDAAKRQTITLIGYQWYALVATLILNLLGCIFLLISGSSEGGADMASSASYLVFITLTSFILWFRPIYLGYCRNEGKAMAVFFYIYFLFAGFHLAYSVYMFIGIPSTGSAGLINTVSMFSQGHILAAVFGTITSVGWAFQVAAGGFLYKRVWDFKNVNSEISMQNATDQLKSNSIKTIVLHQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEP6</accession>
    <name>A0A1E3IEP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028876.1">
        <property type="nucleotide sequence ID" value="XM_019179118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEP6"/>
    <dbReference type="GeneID" id="30196315"/>
    <dbReference type="OrthoDB" id="10390990at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="294" mass="30403" checksum="CD6810A1311EDCEF" modified="2017-01-18" version="1">MSTGGNGSEVDLAFPLSPPRIPAASSESPKSSPDLGTTVEDVEDSVEVPESLRKPVYKQRRGGLGLHVKTGGSSTSLASGTTPTSAGSGLTTTVAWSPSMSPRSVGRVQMPAPATWESIPEGDPAAVREGRASMAETEFTDVSNEADEEAWIDPRAQGARISARGSTSGEPARGSAPRPTIVSYRSSGAFPTEDVQPTSPIRGDIPFGMYGDKNSPVIHWRMGEDGNIEEEAQGKETESPSGLGDAGQSGWESLNAITNGNQDGGSGGIAGFSRASGRRRGPPSGLTMTNQSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IET1</accession>
    <name>A0A1E3IET1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028898.1">
        <property type="nucleotide sequence ID" value="XM_019179140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IET1"/>
    <dbReference type="GeneID" id="30196337"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="279" mass="31388" checksum="A0F27AFA29415C95" modified="2017-01-18" version="1">MPHKRSKKSVRDAETAKKGKNLAPSDTKNPYDDTPRGATRIFTSIDLQTKFRASGRTNSEDTGERRGLPGTGKGANVKGKGKEALPKIMPQETLGEYNRRIESLLRPAVSSAIKTAENQRQAEVADERRGKKERKRRARLEKLIKEGKVDKKVLEEFEKSVKEKKRKREQGKGGDSESEEEEGERGGKKQKQQQQQKEQKEFKAATSTSAPRRLNDIAQAPPSLPQLKRAGEKSGVYGAVSSGKMPLNAGQKRIMEEERERVINLYREMKAKRQESKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFK4</accession>
    <name>A0A1E3IFK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028937.1">
        <property type="nucleotide sequence ID" value="XM_019179019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFK4"/>
    <dbReference type="GeneID" id="30196212"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="924" mass="99703" checksum="75E7BF4B0391870C" modified="2017-01-18" version="1">MQPPPTANIARHTTPPQVLHPSELDHIIDHDFAHLRLSSPHNKSTGRKSTPGGKKDDKGKGVIQQDKWKGKGKGKKKVWEGGECHLLNLPTDVLHVLLTRLPPRSLLRLSATCTALNAHCNNDTVWRHSYINQYFGVGVSRDAGRRKEVEILARGCTGIGERGWKRESLERLRMLERWQISKSSIVVHTPPTGLIHSISLSYPPHTPAPSKGLTVGKTRNKLSPKLLPTDQPHHTRQKVDTVPPSVTRSPPYLLSASLFAGGVVRSDPITGKVSKGFWGPSRDSNFHLRPTIDPSHEPSSVYFPKRSGGFVIWGLKNGGVVWTNVQTRQSGQGGRGGRAVSLNVYSDPRVGHAGEVRDIWTGGQGEDGARFVSAGEDGLVKLWLLVVPPGTGKGKKNTFVEGSLECLFTSSPVPSLLPNRSEDVKRRQNGSPDAIVFARYTSHGDIVAGITADGDLRVFFAASIAPKEVRLDLGSAEAEGEVKMMEMVSHISHIPEGGESVASVVVHRHRSSVVTRYDISSSGTVASTTFVSPSQAPISCVYTGLQADGGISLPKSGSLTPMLARIVSPSPSPSPVPTPGAMAGTAPPAISDLDLSLGSGSGPGLKSSEADKGQFILAGDENGLLHLWSWSADAHAHPDPGEKERKALKSWMVHESKITALDVSCSIFAVGTADGYIKILDPLPSPSPLSFNDDSNTHILRSFHASHLSPAETLIATTDEPDARWYTVNKVGVEDDMVVAAVGRKVFGWRAGVLRGKKGEGEGRRRGEGKGGVRGGAKALHQDYEDYDQALDSPHPLTHSLSQNRPTKPHELLEREAMEDIGLDDPEDALQYALMLSMEGPGASAFASRGEEDLSSEYEAGGAEGASGWDTDGMDEETAEAIRQVEAFERAERAEGEKRRKEKEAEDVEMERILEAIERSERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFN4</accession>
    <name>A0A1E3IFN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028970.1">
        <property type="nucleotide sequence ID" value="XM_019179052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFN4"/>
    <dbReference type="GeneID" id="30196245"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN87410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="533" mass="57055" checksum="1F1A5FB6B3D6B8D7" modified="2017-01-18" version="1">MASGHSVGPGASISDSSFTDKGRGQEVRLSNMNAAKAVADAVRTSLGPKGMDKMIQTGTGEVVITNDGATILKHMAVLHPAARMLVELSQAQDIEAGDGTTSVVVLAGSLLAAAEKLLAQGIHPTTVAQSFQNAASKAVEYLQEMSTPVDLNDRDSLLRAAKTSLNSKIVSQYSSTLAPIAVTAVTRLATSASTNVDLRDIRIVKKVGGTIEDTELVEGLALNQLAMTNAGGPTRMEKAKIGLIQFQLSSPKPDMDNQIVVNDYRQMDKILKEERQYLLNLCKRIKKTGCNVLLIQKSILRDAVTDLSLHFLAKLKIMVIKDIERDEIDFISKSTGAKPVADIEAFTEDKLGYAEHVEEVSQAGAKVVKVTGVRNPGKTVSVVCTGANELVLEESERSLHDALCVVRCLVKKRALIAGGGAPEIHISRLLTSHAHTLKGKEAYCFLAFAEALEIIPTTLAENAGLNPIAIVTELRNKHAMGEKSAGINVKKGIISNILEENVVQPLLVSTSAMELATETVALILRIDDIQFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJK3</accession>
    <name>A0A1E3IJK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029328.1">
        <property type="nucleotide sequence ID" value="XM_019178627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJK3"/>
    <dbReference type="GeneID" id="30195784"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN88770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="606" mass="68175" checksum="C7029ECFBEBE559C" modified="2017-01-18" version="1">MCGIFCCYNKSGDIASYRSRAIACSKRQRHRGPDWSGCYMANNTILVHERLAIVGVDTGAQPLTNEDDSLVLAVNGEIYNHVALRESLKNKDAVFKTHSDCEVIMHLYKEHDTGVCSMLDGMFSFVLVDKSVSPPRLLAARDPIGITTLYMGWHSSAPETLYFASELKTLHEECDNLQAFPPGHFYDSNQKKLVRYFNPSWWDSDKGEVPHNPVDYTELRESLEAAVRKRLMSEVPYGVLLSGGLDSSLIASIAARETDKLAQEQEKLRQERREAIAAGQDVPEDHTLASWPQLHSFAIGLPGAPDLLAARKAADFLGTIHHEYTFTVQEGLDAIEEVIYHLETYDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPNAKDFHEELVKRVKNLHTADCLRANKSTMAWGLEARVPFLDKSFLEVAMNVDAKHKMFSKGTHQEIDAEGRPKMEKYIIRKAFDCSPGGKAYLPDSILWRQKEQFSDGVGYSWIDGRVFFSIPLYPADDFNSMKDHAAKVISDEKFAARAERWSLDTPDTKEAYWIRETFEHHFPTEAAAKTAVRWIPKQEWGVSSDPSGRAVSIHTAAYGEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK98</accession>
    <name>A0A1E3IK98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029413.1">
        <property type="nucleotide sequence ID" value="XM_019178712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK98"/>
    <dbReference type="GeneID" id="30195869"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="404" mass="45190" checksum="6C9425F2CD8490A4" modified="2017-01-18" version="1">MPAPPITLHATPPLAPLPASDAESLYYIALFQLAAPGRYGVETGDWGQNGGKLPYVTHLGHKVPSAYLPNLPGFQDPDAHLSAEEKTDALSWKSYLDANIVDLVNHTYYSLPPNYPQTIAKAQLATLSFPQTLYIPQRIRSVIKSRLTFVGLWGLGGLNDGDAVEEDQRILSEKFITGPGGTVAPRAWTGWRSGQEAEKRRRQWGEQQLDTRIKAAFDPLARRLEGKNYFFGDMQVLLSLFIHPHPFLYLSHSPTTPDLHLFSLLTFLLTPSLPNPLLPTLLLTTYPSLSAYHDRLLTHLSLDWASFPLLRPRPRGVKAASWGETLSSFIPGPSTSASTPNKKEKEEKKEKTSKEKSFERGRWLWFAGAAVSMVSYLFWSGIVAYGEFDDEEGEWIEVEEEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKM3</accession>
    <name>A0A1E3IKM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029434.1">
        <property type="nucleotide sequence ID" value="XM_019178527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKM3"/>
    <dbReference type="GeneID" id="30195680"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27312" checksum="6BDD71A4F6DE4E03" modified="2017-01-18" version="1">MSKAAPYEQVPIVKSTAPAPETPYQARMFLHVGAAGVMLYGFQAMRASTVFGDVMSNQYGGFWQYLTILGLTISGATMLLAGAQDLLPNVHLIRLIKRTFLLIALPVEFIITSTYWSLIIFAPHLMLPPTDPNAAQGAPSSSTAEPTLFRIPLWMDMSMHLLPGVALVFEFFLLENKYRPPFSTSIAFLLASAFGTSYGFWVEHCAEQNGGVFPYPFLTILPLGGRVGVYASATGVAWAVFRGLNWVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKR2</accession>
    <name>A0A1E3IKR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029467.1">
        <property type="nucleotide sequence ID" value="XM_019178560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKR2"/>
    <dbReference type="GeneID" id="30195717"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="190"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="446"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="968"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="838"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115404" checksum="A569ED6833B508CD" modified="2017-01-18" version="1">MSSTSTKAASASTSSFVTSLATNFAIAGGELVAWILLRRYIKAIYEPRTYIPPRDNQAQPMSKHPLKPLWQILKASPEEVLEKNGVDPYVYLRFLIMMVKIMVPIWALSWAILLPADAVNSQVNDKTGLDKLTFGNVASTKQDRYWAHLILNYIFVFWIIVNVWREMRNWLVIRQKHLINPAHSKLAQANTVLVTGIPEEFLDEHKLAGLFSYLPGGVKRIWLVRNLKEMPGLHDRRLKAVNQLESSQVKLIKFARTYKEEREKKSGKMEKKNKTVPDTLSGPMNPQLLKQGSDGKVNGSANAEEGRVFTSVEALGLADQLVPRSKRPTTRLKPKWAPFGLGFLGIGKKVDAIDWAREEVVKTTEELQFSREQLKKDIESIGIAEDKYPPLNSAFIHFNQQIAAHMAAQCLDHHRPYAMQSRYIEQSPKNVIWGNLSMGPYEKNIRTAISWGATFGLMVLWTTPVAFIGVLSNVTTLTTEYHWLAWINGDGFGYTILQGVISGVLPPILLGILMEIIIGVLRALAAFEGHPSKSEVEFNLMTRYFIFLVFHTFFVVTLASGLISAVQEFANNPGSVATTLAAQMPTASTFFITLILAQFTGTMGTLLRVVKLFLYYVRVIATGGTPRSVFTSRYKMNVANMGEWFPKITVYAVIVIAYSVISPVINGFGACFFIFAVFVYKYVFIWCIDVDPAADTGGMFFPKAITHVFVGLYVQEVCMCALFFLARNQNGNASSIAQGALMVVLIVATAASHYTIFVSYKPLRNALPLSLAHLSYGMPGLKDRTQAFHNYSLNEDPENPLELQTSRDPLTAGVVKATNLIPSKLRIDTKIGDKFRQKNALSSTSDREYGVSPRVLERPSDDVTLAERDFAQQPGGAGAISREEEQMTRGEQVELQERRSREEGGLSQMPRNAEGLENGHPDEEPTPAFATSPGRPISRPPSPSDSIASVESTKYFALPGGPGLISRQVDDGNDPNAFFHPATKDPQRVIWLPQDELGLGQAEVAQNKRDGVKSSYRNARLDEKNKVQIYGPPPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILA8</accession>
    <name>A0A1E3ILA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029510.1">
        <property type="nucleotide sequence ID" value="XM_019178603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILA8"/>
    <dbReference type="GeneID" id="30195760"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="945" mass="101357" checksum="A04B98D2FF12E686" modified="2017-01-18" version="1">MSSPAPDDTILWADDEHQSDDDDDIPVFFGAHKPEERLLQTLARPSQPKDSLRRRTLLLSTEKPRHKHGALSDRDYVRLYRSAPSDESDSCTTPASLRGPSTPARSEQDPSNLTFDFGTLRLSTPNDSRDQEDSDPPSEGSDKENVPVPSPAQGAPPVEETSFERFECDNTRHGSLDLNDKDDSIAELDMGGLKLSDFADGETGATYHHIDDFGSCSSDEPQKETPDKEGRVLQPHPSLTPVSATPEHQSLDFDDATSPLEVARAGPVAIPVLHSHHFASIRADVGSPCRNLPPSPMTLPALAQDETPAIRLASIDSPTKLVSPAVPMTPSHTSTVPPADLVQRGSKTLKAEAGGKGKAKSQPLDHKQSTALKMTIKSQLDSAILPKVGAPRSDTMPSSGLRFSSAPSGRTISAGTSSHPVTREISKPHPERPQTLENRPESRPARRPLLKFSSTSASGGSAIPRPALASKSSLPRPKNTVRDKSNSMLPPPSSIPLKRPAVSQPGAPLPSVMAPPRSVLSQPTINHTRPTLGQPARAFQSLGTPLRAAPLFSVGVGGEMVAMPRVGMKSPAKSNMLHKKQLSDRETPRKLGTPMRFGTPRQQPSALVPLAASVPCAANFSTAGPTMTILASSPMRRSSPHKSMDAAQPVPRGSAAMSTRHASENPENAANTTSPPSAASQASSTALSESIQVESSQSSRASPSSSPRPAARRAKRASAAKTPAAKTHKATSNPSSTPSAPALTEKQLKTTTARNTARNQVYHCAIDRQIIRQPGPRPPSPTSKIRTTSDREEEDKKNAREVRARRRKGEPEEDDKPVLEKIEVLKAPGDEEEYTHSPVRPAKRSRTSTGSNSSEGRKRIRWDREILVIHSDGSGKRTPSEKVGDASAGKSCIKTKTPLDEHGNVIDAQRSVEDLKRTRVVVSAIFYDGEEPIPAPASATRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM22</accession>
    <name>A0A1E3IM22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029556.1">
        <property type="nucleotide sequence ID" value="XM_019178400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM22"/>
    <dbReference type="GeneID" id="30195547"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="217" mass="23836" checksum="2F5467140759EB4D" modified="2017-01-18" version="1">MSHCLSLSPSLSQSIGMVRHAQLARCLSSTAGAFQRSRSSTERFSEVVKVNTPPGKTSQRKTRPLLRPSRSHTPPEARPLRSYSHQPPPTPEPPLVRQGSWQPTKKLTYSAMAGLRALHQFDSERFSKAALSKKFGVSHEAVTRILKSKFRDDKSAGGLEGIDALQHGLAFGQEEAMGGLDKPSLKGTKWDRDPGTSENVSPVPSIMRAIQESRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM74</accession>
    <name>A0A1E3IM74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FeS cluster biogenesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029608.1">
        <property type="nucleotide sequence ID" value="XM_019178452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM74"/>
    <dbReference type="GeneID" id="30195602"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000010">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.5, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24291" checksum="2AFBF2E1C3462607" modified="2017-01-18" version="1">MVSFCAACSRRLLSVRPPARLAPVSRPRPFSLLATSRRVDTPLRALPPASYRSATTFSIGSSSSAAPHLPPIPTRPNIKVTAPSLAAIKEEGYLDDDVKLLPPEEAFLNISPEAVQQLVRITSREPLDILQRNKLALRVGVESGGCHGYQYLMDITEERGVDDYVMQPEGVHCIPIVVDLTSLGLLKGATLHHATELIGSSFRLQDNPQAKEGGACGCGVSWEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ47</accession>
    <name>A0A1E3IQ47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029826.1">
        <property type="nucleotide sequence ID" value="XM_019178107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195252"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="855"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="177"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="528"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="822"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN90724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1357" mass="150167" checksum="2804B011063ED307" modified="2017-01-18" version="1">MDSSQHTSVMGDSYSEKEATSEPTAQYTHPLWRHSLPFVKPKHPPPPPPATLDDAPVITDITANWFDYLFLNWISPLMALGSARPLDDRDLWKIDDARSAKAYSAKLLGAYRQRTQKANEKNARMLDSTIPLPFTRRILYSISPNGQRKEKEYREKHANKGASLFMSLGDTFGVYFAIAGSLKLFADVCAAVSPLLVRRLITLAGEYQASKQAGLGEPSKGDGVGAAIGLLVLLLASSFALHHYMYMSMSVGVWSRTAIVTSIYQQALQFTQKSRGLIPNGKLVNHISTDTSRIDFAAGLFHTLWTAPIQMVIIIIILIIQIGYSALPGIGLLLITTPFQAYLMKFLFTYRGKAAEWTDKRAKILQEALGSMRIVKYMAWEAPFLDRIHGFRKMELKYIRQLLTLRAGIMAFATSLPVLASILSFVTYSLTSHSLEAAKIFTVITLFQLLRLPLAIWPMALSSAADALNALSRLEGVFGAELITETRRLDPKMEEAIKLEHATFTWDAAPEEDGGKKKGSGKKQGKEAKVVENEEKPQKAIFQLADITLDIPKGSVTAIVGPIGSGKSSLLQGLMGEMRRTTGSVTFSGSTALCAQSPWIQNATVRENILFGQPFDEERYWDTIHDASLEADLELLDDGDSTQIGEKGINLSGGQKQRINIARAIYFDADIIALDDPLSALDAGVGKAVFFDAILGALEGKTRILVTHALHFLPHVGNIITMEDGKIGEVGTYQELKGRPDGAFARLIRDFGGEDQAEEEMEEEEEAVEAAGVKRVYNRKDMVAKGKSHTLMTVEERNTGNLTKGTFWGYFKAGHGLITLPIVLFAVVLAQAITVITSFWLVWWEELKWPESNGFYMGIYAGLGFGTAFSMFFQMFSIAMLNYFASVRIHASAIRRVMYAPQSFFDTTPLGRILNRFGKDMDTVDNTLPDALRMGVGTGAQIVGAFILLAIIEPWFLIAVAVVTLLYIHCTMFYRRSSREFKRIDSILRSSLYAHFSESLSGVATIRSYGETERFCRDNIYAMDTENRAYFLTVVNQRWLGLRLDLIGSFLVFAVALIVACSDISASNSGLGLSTIVTAQSSFAWLVRNIAEVENDMVGAERILHYANTLEQEQPHQIEETRPPTSWPSEGRIEFKDVRMRYRPELPDVLKGLTLSVGASEKIGVVGRTGAGKSSIMVALFRMSELSQGSITIDGVNLSKIGLNDLRSGISIIPQDPLLFSGTLRSNIDPFDTKTDAELYDTLRRAHLITPTDGIAPDSIRFRLDTAIEEEGTNLSVGERSLVSLARALVRDTKVLVLDEATASVDLETDANIQETIRSEFKDRTLLCIAHRLKTILSYDRILVMSDGQVAVSFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQD7</accession>
    <name>A0A1E3IQD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029916.1">
        <property type="nucleotide sequence ID" value="XM_019178197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQD7"/>
    <dbReference type="GeneID" id="30195343"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22357" checksum="7E9F62D531230D03" modified="2017-01-18" version="1">MSSPYTYTLSPQVYALPILHAAAHPSHTTLGLLLSSSSMSDKEQTIDHAVPVLHNYASLSMVMEAALALVEEWGKGKGKRVVGVYVAREDGEGLGRVGERILAALRTKWDGAFGLVLDNGRLGSGQFAYIPYLSTASGSKAITSSSPSAPLPFIISSESLPAQLLQLIREKKVHRDVRDFDDHLEDSSIDWLENTTTVSTLQKYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQH7</accession>
    <name>A0A1E3IQH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029890.1">
        <property type="nucleotide sequence ID" value="XM_019178171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQH7"/>
    <dbReference type="GeneID" id="30195317"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129882" description="DNA-directed RNA polymerase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="43944" checksum="5584DE34B1E95529" modified="2017-01-18" version="1">MVTPTLALFSSLLAASSALAHIQMSWPYPLHSSLNPATPEALKDYSMTSPLVTDGTYPCKGFITTADDMGSNAEWSAGSTINYTLVGTATHGGGSCQLSMSYDNGDTWSVIFSHIGGCPMEEASMTTDVTIPSDAPSGQALFAWGWFNLQGNREMYHNCAPVTITNGGSGLTNTDDYPTPFVANADVNDCVTIENTAVVFPNPGKTVKYGGDYSSSQPTEAAGFTGSNCVGPNASSSNSSSGSSSASSSGAATEASTAASESTAASGVSASAGISISLSASLGVGENAQATSSSSYVDASSPSSVSVSSSAASATTTSSSTSSGKSCKAKRALKAADNARARHVRRAPKRFAASKASHSSSKRDVSPEAVVQKRDGKRYAASKASHASAEKRTEGAGFEGRAGVKKSAASKASHPRDVKRGLVGRGIFETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVU9</accession>
    <name>A0A1E3IVU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030305.1">
        <property type="nucleotide sequence ID" value="XM_019177554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVU9"/>
    <dbReference type="GeneID" id="30194684"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="505" mass="55436" checksum="25918D0DD5CDA155" modified="2017-01-18" version="1">MPTLVNSSEPVMEPNEKLTFLDRVTAGLRTQYKLKDNEVLYHIVGFVIEEKPPIIPETLLIGQTSCYAGSYHDVCGTSYGYAGRGPVVYRLLVLDNAIVFEGTSSDEAQVVGDFDTLDKRLKDGSVKVGRSLLVQKSEGEDDLDYTLVKDVRKLFGAAIEQLEAIPRDGQPLKRLPSPEGETWTTLKDMVKTFKLENAVTQPEPFFESARLSTKKVAELNESRKREEIPASEGNAESGPRAEDSEVVAPLPEGPESTDAQPGTDVDPKEPKRNRKKTKQQSVNDPPPKNRRDRSPSPGGGGQGPTKRRSARIRAAQADPSATTSSATKEGQHGRGAKTAGRTFGSRVGNIRGTNDNTANVLIGKDSLESASFKADYDVATTEYDPLTAFNLQNIDSYIPESNASQKVRSLYESMLMEPVMNGGQTHHNALPELRNIEEEVPKQTASGVMEDDIIDEEDNGSFDRAPSAVYDDPLEEQANTILVIAGKEIFNKCLNEATKFVYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY04</accession>
    <name>A0A1E3IY04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030413.1">
        <property type="nucleotide sequence ID" value="XM_019177662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY04"/>
    <dbReference type="GeneID" id="30194794"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="449" mass="50296" checksum="AAD620BC373B7E68" modified="2017-01-18" version="1">MDRRPHRSPLPGAPPPGTSSRQQTFEGLPTLEQGFYPIQRHQVHPGDAPPWTSQQPVHILRSESELNPQQDIYSTGVYQELPYASSEIPQQPSSSSRNDRDRMQGGQGEQQQQRVGRKRGRVPTSCTECRARKQRCDGAQPCLQCSKRQVDPSICRYEIDPRTTSSREAGQEGTGPSGNEGRKEKRRRSEAPMRDDVKALAHGMWNAPLAFSGGRFDDERRRAGDDGLARHQMTERNPRPPNLDTMLNDLSAYPMVGSGIRRRWDESRSGMQQGGSLNMDLYGVQSAHSGSNSHHNRPPIIPPSPVLRPRSEADVRGDSVYEGYGRTKRNSAPKSSSSEGDASPMARRVRDLSPPGPQKEDSTARNAFKRNGFFISDAAKMILGPTTAAKEARPQSDFDKAQSWSPENIKSRCLGKLPAKERCDELVQRYFDRFNRQVFLFCCSLKNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY10</accession>
    <name>A0A1E3IY10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030628.1">
        <property type="nucleotide sequence ID" value="XM_019177475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY10"/>
    <dbReference type="GeneID" id="30194601"/>
    <dbReference type="OrthoDB" id="10523786at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130089" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN93523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="34539" checksum="4F359E0720DDC36C" modified="2017-01-18" version="1">MLTKSLTLLALLALSIVSSRPIDMSDGDDVDGPYLARGGSVTVSPTGTAKNAEESGGHDEDDGEDEDENEEDYGTESVSFTESATSASKSSSANDDESASVSVSFVRQRAIATGSVSVSSSAVSLAASQPVTPIPSKASATPTLPTASAQTSSSSSFAPTPTPSASPSSATHSQSHFSPRSTFSSLAPSGTAINSTLAEPTGSLESFSDPVGVSVSTFIVVFVGTVIALLGMPLLICLAPAVKRGHVANKEWKGKRLGSESYWSSRGSSLRTQSALDSHSNIGSSAGNSDKIPQVATPSTMLGFTPTIVISDRDIERGPFEYPIFTEKAAMTESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZZ4</accession>
    <name>A0A1E3IZZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_05055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030734.1">
        <property type="nucleotide sequence ID" value="XM_019177153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZZ4"/>
    <dbReference type="GeneID" id="30194268"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="469"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="713"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN94203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="806" mass="90770" checksum="6D97FEC36A80AD37" modified="2017-01-18" version="1">MAPRNRRGRAKVATPTSAADTPITTAQSSPARSRGRSSSLSPIKSGHSDSESEPEDKENGRNADDDNDTEESKTAEQDGTELTERTAEDEAEKDHSCPKGIRFRYPPSAPDFSTLSDREKAFKVGRFLPCTVAECACTGLEPPVDRVVKLGKRDEDEDEDEDDIEDEDEDVSMEDAESVESMERRKKEWRTEEGWWRICGRCGHGWEGQGHIWASDIPPKEKTRRGKVVGRMEEILQDEDNLLTFPTPSTESISSLLKQLDHFVRPAGKTTAPSLPVPIDMSTPGSETPNEVTDDEPPRKRRRQESGSDAPSDEDNESPVKDDHPKHGKKKSGKSAVKGTKPRTVVRGAQGYIPMATDPDGNQHVAGHLPISAGGQDQEMEDEEEEDEEEEDIPLARRPELDESERKRRTEIKVKEKEREEELVSRLATGKADNAEEAVEIWEGIELQKLPLRPAAIEQANQEIMLPVVSSRNPTPVATILLVGLKNVFQRQLPKMPREYITRLVLDKNHISMAIVKRGWRVVGGICYRPFEARGFAEIVFCAVDSSEQIKGYGSHLMNSLKDHVRKAHPTINVFLTYADNYAVGYFKKQGFTKEISYPRERWVGYIKDYEGGTIMQGRMLPKVKYLEVHQMLADQKAAIIGKIKTLTKSHIVHPGLDVFKDRKPEGDNRKLAKEEVPGLAESGWNPDLDDIIRQPKRNPHHVLLQLVLNDLQNEGSAWPFVKPVDANVVADYYDVIAEPMDLSTMEYKLENNHYESIEDFVSDVKLMCANCRQYNGEKSTYTKQANAMEKALDKILKKRQSVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J031</accession>
    <name>A0A1E3J031_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030703.1">
        <property type="nucleotide sequence ID" value="XM_019177122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J031"/>
    <dbReference type="GeneID" id="30194236"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="202"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="452"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN94172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="507" mass="55967" checksum="956F33A868E0A1BC" modified="2017-01-18" version="1">MFQKVSDKFHRKQQSSSSSGKTQQSSPTGALSKVSSQGQPAPAMPQNHSPMEGIESTTPVMPQDETSHKPSAAGSSASSSLSNIPPQARTLSAALGVHGSSGEAHDPNQQITSSVSRSSSADEERMREKAREAQEQAAQAQANLHNATQQARVAAINAAATQAALETGSQLPATAKVPVPSTGSQSGQPRRKTAGRYALSDFMIERTLGTGSFGRVHLVRSRHNGRFYAVKVLNKEKVIRMKQVEHTNSEREMLVRVRHPFLVNLWGTFQDVNNLYMVMDFVAGGELFSLLRKSQRFPNSVAKFYAAEVALALDYLHSLDIIYRDLKPENLLLGADGHVKVTDFGFAKYVPDITWTLCGTPDYLAPEVVQSKGYNKSVDWYALGAGYPPFFTEDGNPMKLYEKIIAGKVRYPTYFDMMAKELLQNLLVGDLTKRYGNLRAGSSDIFAHSWFAEVDWDKLYRREIPAPYVPKIEGEGDASQFDRYQEADVSAYGKAGIGQYDHFFMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J080</accession>
    <name>A0A1E3J080_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin structure-remodeling complex protein RSC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030739.1">
        <property type="nucleotide sequence ID" value="XM_019177158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J080"/>
    <dbReference type="GeneID" id="30194273"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="671" mass="73690" checksum="DD9052AA92850A4A" modified="2017-01-18" version="1">MSSRSRPKRASAADTPTEGTPRTRRRRAQLEYDEPAIEEDESLDEDAEGEIEEEEDDDESEDVAPQTKKRGRPKGSLNKKTLAKDGEEDDEEEDKASWRRGRKSVSYKEILPGEAFQEDDEDEDDDDDESHGGKRRGRPPKRAAGEDDGDDERDGSYKKEKIPGGSGRGGFSVKGAAAAAARARWEKVRREKAERGEEDTPKPSRKSNNVVRKHAIGPPADYQMGTTVTIKGEEYTVGDDELVVASDPKGDTKIDECGRLLGGREYKPVTFTSTERRNSDRLYALTIDAARACGYGDSLAFLRRYPTILKLSCTAGERLKLIDLNRISGNLKHRQVTMVALRNVYKAMGAKVVKNGRHVVDDYYEDRAAAECAAEGIEPGSLVPEEEFIQIAQNTGDRGARAAANESRTLASLSAFYTAGGLTTQFASNGIDPWTDGGWGNKRSKLKTAGVTEEDWMYKTAEESRLVDEQLKGFRAERLQVLEGVDGARGWVFAAEKEAEGDKHRFIGVESSSEIKKSGLSNEVVMGDEGTSQTGGDVMMDEPPKEAGAIIVEKEGHVSSTHNWGLGRKWQAGVIRAAYEPHTNTPHVPQSTQPSGNAVQQLSSKPILSASSNLSNLHHVQPTFAGSATRGLASVEYVLEKVEETEVQKRSRLVQEAEEWEKASRAKQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0J0</accession>
    <name>A0A1E3J0J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030900.1">
        <property type="nucleotide sequence ID" value="XM_019177319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0J0"/>
    <dbReference type="GeneID" id="30194441"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="383"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="715" mass="77348" checksum="2A0D16A5CF480806" modified="2017-01-18" version="1">MLPRLALARAPVSLLSRSAVLSRSLIRAPILSRSVPQVQSLSSILSARGYSVAAQGKPEDDFFASEGDAPAPTSLRQDSKPIEAEEVDNTASFDSLKGRMNHDTLKSLTFKPFKFVTMSEVQKRVLGLLPELAGGKLRGPAKEAAEEQGEPLIDETRLREDLLVKAKTGTGKTVAFLVPAIDSRINKLEELSKAAQADGTIPDKHAQGRIYREVSRSHAGALIISPTRELATQIAAEAQKLMTWHKEMEVHTFVGGESRVKQLRQFSRNRKDIVVATPGRLRDLLSESNVKEALSKVDTLVLDEADTLLDMGFSADLEYIIDHLPKERQTLFFSATVSKEIKNIARKSLRPGHKVIDCVPANESNTHLHIPQYCTVLPSAADQLPHVLRLISHDQLIHPKDSKVVIFLNTTKQTMLTSTLVRQLKGSLPQNTWTYEIHSKLSQNQRTRASDRFRAEKGPSVLITSDVSARGVDYPGVTRVIQVGIPSNAEQYIHRVGRTGRAGKQGRGDIVLLPFEAGFLNQLNEVPIKAIESRDLAAEVHELATSQKANAAKLAAIPERVSELLPTLDADAVEEVFMSMLGYYVGKGSQIGMPSQGILEGLKEWTTEGAGLVEPPYVSEMFLKKLGMGPRKEKRSFGGAGRGGAGGGRGGRSFGDRGFKDRGEGGGGGFGSRGGSGGFGGRGGDRGDRGGSRGGFGGGFGGRGGDRGDRRSRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1W9</accession>
    <name>A0A1E3J1W9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031107.1">
        <property type="nucleotide sequence ID" value="XM_019177075.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194188"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="727"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1298"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1298"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1310"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1358" mass="145611" checksum="0D8AC5BE9C02600E" modified="2017-01-18" version="1">MNRITNAFSAAIPSANSETSSIHHKESPHISSPLEPPFPTHLSVRTPNERRLNAPSSVVYDDPRSIYYPPLAPPLPSYAPPSLTRPSRPTLLRHLTDEGLYSQPPSYRSASSSQTPTPRARSESRERSDRGVRVNLMAAAAGSTARKGWGMSSATGTTRMNRMAEGPSGRYAVGGGQYLRVFHIDDPSSGSSTPVVQEYPSSHSDRNVIARGPGGATISEVVNLWKSSWPVGKGVNDLDWGVAAWDHKLVTATPSGNFMLYDVEKEKVDKEISSGSFRPLNCATFCHQPAYCHMVLIGGADGNIKLLDLRTGDPPSRRPLRHSSAITSLCFSPTDASAFVIGLDDGTIKRYDWRMAGKHMGTAYGAHGSKAVMDLKWKVGDEGGGESGGWLASAGANKIVQIWDMNQSWEKAPSSTHSLYTPHPIRRIAWRPNHSTELVVVPVTQPLSTAQGVDPASSLPRPTVAPIESKDKSTRLNVPKLFKRSSSQASDSPTEDDDPLEDDDAAHLSIWHVRRHHVAKYNVPTQDGVAIDAAWRDEGSLVVTFQNGGLAQLDVERKIHPTSRNASGQGRLPVPLPLDQVPRQVSSWSSRGDMAFAVDRFKAGEIPFDDLKPEYSRPVPHPYNSSFSNPYHVSRISDPPYHPIQSIGSIPLHSSLPSPPETTFMAKWYRMEGGGGAELCRWNAGVAAWVGREDDARLWVFMAGLFEEFKSAETHAKAVGFEDVWQKGSGQVKEKRPTTSRNVSPKGGHARLSESQDPAPQRQTPKYTSVALQRFTPPPSPLHSPERSTSSLPSSSSDEGSEDDSEEEIESWKPKSRFVTFMEPQTQVAEGGLELKLHGEAMRRDSSGSSQGSPVFERKGAGESSPIAIHNASAAGQGNTVGGSLSGSLGAKKSLSRMFSRPNPHAHSHHHHHKPDAAFDFYPDPYGIIPDQPMSSTTLVMPGTGGTTTATGSSGSYSGPGTGMVTGAAGLVSRASTRSSPVLAALSLGLKPSPRMGLLSLPGGSITIPTAQLSQAAGLASHEYGSGITEAPLAGRGSGEGATIIAPGANGVGVNSRVGSGSMLGKEMRGREEKFEKSEWEEYKRGRMKSLETWWDACVDNGEVQLAATIALIAQPLHQFPPFQLERIAHAYADALESLRLPLPASYIRRFSGIPSLEVTAQDQGVTHTLGCDRCGKSTGSLEDIGVEGKVFWWCKKCKMGAKECAVCRKAVKGMWMGCRKCSHGGHHACMRLYHSRATLVPFGKSPIDHTNHYQHQQGVQASHISFSSAGAASGAQSINASTAGLTSGYNASAVSGYTQSGTDVSSTDVDGDGLTEPDDESEPGLGNLENNGGFALCPAGCGCRCRKVCPLKPAVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1X9</accession>
    <name>A0A1E3J1X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031117.1">
        <property type="nucleotide sequence ID" value="XM_019177085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1X9"/>
    <dbReference type="GeneID" id="30194199"/>
    <dbReference type="OrthoDB" id="2575565at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="43271" checksum="B82453527F7A7AC3" modified="2017-01-18" version="1">MLLPPRPPPSLSRPALYRLFLHHLRLLPDPQVWATAVPLVRKLLSTPGPPPTAPPEDAEARAKWESIRAWRAERAMKKANKELSQLRAAVACHPHALSRLIESSYYQRGASRWDRLRSILIQSNPSSPQLDTLSTPIPSPLRPLMPRQPGPSDPIVRARSAIPERRRENRKTKLHERNWNLMKAPIYLPDPRPGSGQGREKERAKVENMSILAGISEGSITTLNLPPHIARIIPNLGSRRKLPLKPYPPPRPSHTKQNPSTWKLPREFTGRMRERVYRRVWDSLPWVRPVSEGGAWKSCTWVDVQAWEQGVMGRDSTSSETRGKSAGKKGRKAAKVNQAYEDRDLDPRKWPHATDRDYQWLARDFSEAVGSTADVIHKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J218</accession>
    <name>A0A1E3J218_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030984.1">
        <property type="nucleotide sequence ID" value="XM_019176952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J218"/>
    <dbReference type="GeneID" id="30194059"/>
    <dbReference type="OrthoDB" id="2570717at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33267" checksum="E986A15BCE745E62" modified="2017-01-18" version="1">MSSSEGFASSSNQLVIDPALTNPSEDFAVFAALANGVAEDDGHSTLQAAIVASLTAHQHDDPQGQVTFGDEHSDHSTFDPYASANAQAGPSSLPASAPAPTDAPVSSSNAPPPPPATSAGISTNAEGHLVHDPPPTGPWPTRDEAHGAVREYALTHNFDVNVTHSDVYRRVITLGCVKGGTYRCTRGPAHEQVRQRGKRSGKTGCMWRVTLRDGPPQEGQEVEGRWNFSGLTDLVNEHNHPPITPSQNPKARHRTITLEIKEFVYMEVDQGTPTRQIWGKVQKAFPDCLANLVDIKNIVGRRKKELPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Y4</accession>
    <name>A0A1E3J2Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031193.1">
        <property type="nucleotide sequence ID" value="XM_019176718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Y4"/>
    <dbReference type="GeneID" id="30193814"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="22388" checksum="66B85673651F4E39" modified="2017-01-18" version="1">MASISRHVLKRGYATAAAAPAVKAPIQLNSLTGTYATSTYLAALKKSSKDLEALAKDVEAFDRSIKEDAKISAFIQNPTLTASERAAALKTILPSSSSPILLNLLSVLSENGRLSAAPKVFADFHSLMAAYRGELEVIVTSAEPLDNKALTRLDKALKTTEIAKGKTLKVVNRVNPSVLGGLLVDFGDKTIDLSAYTRVQRFNNALTQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3N3</accession>
    <name>A0A1E3J3N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031005.1">
        <property type="nucleotide sequence ID" value="XM_019176973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3N3"/>
    <dbReference type="GeneID" id="30194082"/>
    <dbReference type="OrthoDB" id="2575342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="526" mass="55107" checksum="CDFD8EE15B9EF4B6" modified="2017-01-18" version="1">MPATPSLLPTHPSSSASSGSTAAAYFPELGQSSDTAAWEAVLGSGSSSVGGNEQTNGVVRRRTPGMASSSTLPSSSTAASSRSASKTSLLSTPPLLSSPPSASPSPSRNASSSPLPHPLSHATPNLPSTLIDTRPALQRATSKTERQVAESSNGGSEWSDWGSGRGSLDVLRMTMEEPEGGGGEVEVLIHGVKPHESLAGIALLYGIDLTTLRKANKLWATDPIHVRSHLYVPLDACRWNKASETLARGPGEGQVTLHPKRNKGKGKEEPNNSHVYPNGEVEEADESGHDPQKTPRVLDIVRMPSSQLRPFPRRRPPDPPSRSSQDLDRVIQSERDDSTEGIIRRASLTLGREQGPSIIPDLSTLPPPLRASSADPGKHKSKTMVRLRPPQATTPLQTSSTLANRLSSLFTIAPPPPHMAPLSSPGGGVSPITPLPGSGVSARGGGGRSSVDSSASGRTAAPLNDSRRGSSAEQAKGRREEMELVTRVREGVGLGLGMGALGGGQSFPGRKSRSGNRYGKAREKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3Q0</accession>
    <name>A0A1E3J3Q0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Telomere length regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031025.1">
        <property type="nucleotide sequence ID" value="XM_019176993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3Q0"/>
    <dbReference type="GeneID" id="30194103"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="673"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121698" checksum="670CCDFD1EDC5803" modified="2017-01-18" version="1">MDPTEALHDLRDFLRLPVQSIDDLSFRISSTLSALNIHRTSLAPSSITAKDLKAIERYLPAVQGALIQDVLPHFVGILDGDARSSIKALFSPPRQAEGLAIRRTIALSSYLTLPSYVKTPKSGETSLPKPMRSFLISLLSDLATDYSIDDIYYGIFSSDQTKEGAEGMNRLRWEEALKAAVGIPAKVGNATGRWKIEESDDIEVPPRLLPKSYFDGFVRRFESLLYEVSQESSQDVAPLRQVLEKLASVGLLIAEPGSDLSRVPSLLTPLLPSLLNHLHPEPSVPLPPYPDTFLPSLILPLPSSTLASFTESLLAHLTHHLIDPALPLAPDQPDERVKRAVSVLKSILGEPQVGGEAWEAVTRSVLSGKGKGGMSMNAWKEQARNRLVVGWVAEGGETAAKAFIEVVVDAWTDPKYVKFSMYSQQFRLTHMLLQAFSLLPRYWPWLVQLSYRGRFITSFQSYLSHPDPSIRRLGMVVAEILSELTIIEDDMQVDKSEADEIEELRKGLEVDEDVDEERLPKKPNGPKKKAESKRLRFHGMWEGTGDGKDECRWLRRGLGVRDADATIGSEWEGWLLGWNDVPQIPLQPEEAPRPRGRIHSKPSRPPSPKTKKPRKPKIVMLDDSQVDDPLSGYASSSPSSSRAPSPTPEYLEEVANDPTLGLDEANRKKVQRPVYIGQLVALLKEREKPECVEMALQWGEGLVRAKREFGTELSENAVAVTLMTLGLNDQFQIEDFDDKRQGILNALAACAPKQAAPFLIEQYFNPQYSLQNKSYILTALAMGARELAGLSVPQASRTTRAIDFPSKTLPPNLHKKYVSAADVPPSRRLEDNSQSQIDQAIDGVRDLILSKGVKKGEETVPEFARERRLRVGEPKRAKVADVNSLAASQMARATRPPPVVPFKAIAAEYFILPLVNRFWHHFQDASIREERAVQMGSRFRAAGAGLVLSPMAIEKFLMALALMLDAARHSTVFLSVICPEAMELAVTIGVRHPAPPKLSSDSELDDLSRAEAQVLSAALELALVCLDIAVDLDGGRTLAREKSALILAAGEWASEVFKTETEGGEVSAGQGGRNEGKIRAEAAGIIIKVGEIGDKWGNLGMGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J403</accession>
    <name>A0A1E3J403_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">L198_04832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030970.1">
        <property type="nucleotide sequence ID" value="XM_019176938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J403"/>
    <dbReference type="GeneID" id="30194045"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="40776" checksum="DA8B54A1B0F8CDE2" modified="2017-01-18" version="1">MSNERIRGIHVHRPVIYGSHARLLTEAERQLAPPGHTHRWTVFINSAASPPPSDAEDIDYLPGGADDMMIDKPPFKVSETGWGEFTVAIRIQFINESLEKPLNFTHNIKLHHMNQPADLPVVTAAPSEAGAEGSVAGEVKEEAEEGVKMEVDTPAETPIDTPAPTAAPAPAPAAAPGPESTPAPSDPSQQAPPSTSTPAPETAPSTPASSLPAPYAAPVHSWQYDEIVFHDPPRVFLDILNAHPPTALPPKNRRAFLTQRQEADGKKKKLNSGLAGRSAPPSAAGSVAGRSRAGTAETGAGFLGTPAPDMGQPIPNILGVVGNQMSTLDVPLEFSQEMAKGENNLMVEARIKIVDQMDQWRERLIALEKELVAAKEEVKSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4E5</accession>
    <name>A0A1E3J4E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031394.1">
        <property type="nucleotide sequence ID" value="XM_019176466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4E5"/>
    <dbReference type="GeneID" id="30193560"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="748" mass="82065" checksum="6257FCEC5670EB23" modified="2017-01-18" version="1">MLKKDGTGLDSEAVIDEAGNIKIFLTLKKPLPELPADYALPVEEYALDLRPEAPPVGPMYIVVYLPYLSLALRLILSHGHHVRIATHTTFKDFSLEEHLSFFDVGGDPHELMAYMVKNPGLLPGIESLTNGDIGSKRKMTGRMLEKFYEATYKPDPLTQKPFAADAILSNPPAFAHIHVAEALGIPVHLTFTMPWSPTTSFSHPLVKVQQSNAEPGLTKYLSYAFAEQMTWQGLGDVINKWRRKQLNLDPLLGLSGPSILDRLKVPWTYCWSDAFIAKPDDWKEHIDVSGFYFMPSDTDYEPTAELKRFLASGPPPMYIGFGSVVVDDPEAMTRTIFEAVESNKMRAIVSAGWGGLGNTNVPRSVYIMKESVPHDWLFAEGRVSMVCHHGGAGTCAIGLKEGLPTIIVPFFGDQPFWGAMVHQAGAGPSPIKPKNFNLETLSSAIRYTQSQSAVTAARAIASKISADDGEAKGVESFHKHLPLLAMRCDVAQSKIAIWWSDELFLRLSAGVAAVLVEQKITSWEKLRPYRSKEYDTRKAITDPVSGGATAVLEIVTDASEGVFQIFSTKPHIGIIKTATIAPRAIVTGVRLVHEGMENMPRLVGSKSRPQADVTDTSSGFREGLRGFAYGVGDGISSLLTEPFRGAKEEGAVGWVKGMGRSYVSVAMLPAAGALGLVALPMKGASKSLHTFMYGRQEKVLKPPRQAISIEQGYKLQPAEKKRILKLYKDALESDEIKERQEVMKKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Y9</accession>
    <name>A0A1E3J4Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_04526</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031572.1">
        <property type="nucleotide sequence ID" value="XM_019176644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Y9"/>
    <dbReference type="GeneID" id="30193739"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="348"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="418"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="489"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="840"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN95907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="923" mass="104605" checksum="7A748F27F608619B" modified="2017-01-18" version="1">MSQPLTRRSLHPQPSQPSTYTSKVTVESDADARLRDHQSGPQSQPLTKAAFGGRKGSAAGGSGKITKREWIMVGGLVVIGMYARLWKIATPSSVVFDEVHFGGFAMKYIRRKFFMDVHPPLAKLLITLSAWLGGFDGKFDFKDIGKDYIEPGVPYIIMRLFPALLGIALIPLTFLTLLALRLSHTTALLGALLVTFENALITQSRLILLDSYLVFFTGLTTLFWVRFANEDSEGRAFTKSWWINLFCTGLSLGAVVSCKWVGLFTIAMVGVGTIRQLWLLLGNLKVTPRQYIRHFSARVLCLIIVPVIFYMAMFQIHFWILDMSGDGDGFMSSEFQHTLQGHGMEDTYADVGFGSKVSIRHVNTQGGYLHSHPHAYPAGSKQQQITLYPHRDDNNVWRIVNASSPDGPASFPWDDLPFEEVLTGTKIRLEHVTTEKRLHSHDIRPPVSEVEFQNEVSGYGFPGFAGDANDDFIVEITKKTRGKSDRQAKHRLRTLRSEFRLRHALSGCYLFSHKVKLPEWGYEQQEVTCNRNPTWENSLWYIETNQHAQLPYDAEKVNYQRPSFFEKFFELNAVMWRTNAGLTERHAYDSRPQHWPWLRRGINFWVKDHKQVYLIGNPVVWWSSTAAIAAYLAVRAFLVLRAQRGYRDLHQPKTAFYDEICAFCIIGWGLHYFPFFLMQRQLFLHHYLPSLYFAVLLLCTVFDYLTSTLKPKVRLNVAAVFLLLALWAWNHWSSLAYATEWTKHGCENGKWLKTWDFSCADFHDNLAMYQSTPAMSSVKIGGDLGPDSATTTLVEEVPEPIQNAFEKEAEPVEEKTLAPVGPVPEVQMEESSAVFIAEGEEAPKQEDLRAPVGNDAGDPAVTEKDEAGGWHGGAEDEEKGQEEEEKVKIKEAEAPVGAKVEVKEMEMDAEQQELVDQILEQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6D1</accession>
    <name>A0A1E3J6D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione hydrolase</fullName>
            <ecNumber evidence="13">2.3.2.2</ecNumber>
            <ecNumber evidence="13">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="13"/>
    <dbReference type="EC" id="3.4.19.13" evidence="13"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031666.1">
        <property type="nucleotide sequence ID" value="XM_019176256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6D1"/>
    <dbReference type="GeneID" id="30193347"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="517"/>
            <end position="519"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="569"/>
            <end position="570"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN96420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="696" mass="75215" checksum="19372B367D31EA79" modified="2017-01-18" version="1">MPPTESSPLLSPSTLEAGVPHTTPSWHFWNRPPFRQVRFVSPSAAMHGADDELDQPDRPKQPFYRSEEAMGRWLIYCLLVLVGMILGASFSKHWTRGEGKLGNGPMVPPVWTLPPPTGLPRNDPYLINATSAAVASEDVTCSNLGLDILRNKNGSAVDSAISTTLCIGLLNAFSSGIGGGGFMVVRVPEEHYVPHELLKEIGYEGQLQEGRVVAFDFRETSPEKSEVDMYGTSRAGRAAAQVGGLAVAVPGELRGLEAAHKLYGTLPWEDVVMPVADLAKGWKVSRELAKRLRFFGQFMLSSPAWKAIYAPRGELLVEGEFIQRTNYGKTLEKIAREGAEAFYHGEIAESTVETIKNAGGIMTLNDASYKLSKALKHYKALAYPAIHGTFMSKEVYTTSAPSSGGVLLGLLSVLEPLNITSTGGLRDVLNAHRFIEALKFAFGARSAITDPAFAANRSALEDVHSKQWADDVRAKITDDATHSADYYGLQYDTPIDHGTTHISVADQWGGAASVTSTINLIWGSHVMDSKTGIIFNDEQDDFAIPGAADAFGLWPSPWNYPMPGKKPLSSTAASIILNPPTRSHPSTLYAVLGGSGGSRIFPSIAQVVLNLFSGKDISQSIEDYRLHNQIVPDLTTMEVGPEGENRELVEGLKAKGHRIGEFDVNIGISEVQAIVLQDGCLYASSDSRKNGIAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Q8</accession>
    <name>A0A1E3J6Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031793.1">
        <property type="nucleotide sequence ID" value="XM_019176383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Q8"/>
    <dbReference type="GeneID" id="30193475"/>
    <dbReference type="OrthoDB" id="2563644at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="817" mass="89346" checksum="E0F6FDF7EBDE03A3" modified="2017-01-18" version="1">MEDSHFHLAQHDHIDSPIQDETAEALIASLKAVINNPNNAGHHQHAAAEGETHEGQPDADAGDEHHIAISEPREADPVETLNSYTASGTNVVNVAIRRSLSVLFQLTTAHSGLLEELNGVGAIHSLAQNLKALKEGNKRQVEMLKELTAQIRASEMGVDLSRQFPDGLDSEPSPVVLRTDYEALKAQHDALVASTATAPTPAPVSGASHTAEAHQPSPVKRLSAPRRGRPSKAATQAAAAAIIDPETFTGGGTEPIKSISLKGNSTSEGRKKRSLKLEHLIHKMANRRLGVEYAVSNYESKGHRTLPDPESRPLSADESPNGVSEFRPNFQGDVHADSVRPFVDQVVEDVWDAWQASAVEGDAEVDKPKIKEAMNIYWLRLMKRWEEQEAFKRGEVHRDQLSRRKQNTYRRQQSLLMRRTGNFDQSPLNACRLRAHYRTLLTIDFSTATSDRPEPERQYSLQAWEAYRRLACGPKAGEAHEVLDQWWQSPVVRHLLILLDEFSQDQIAQAKKKGKPKQPNPTFHLPPELWMRTEPPALRPKDANGLPLSGAPGLILFRFHVSQEAIDMYPEWAKGLYDNPPIPAEDEGLPTLAEILSTPPYTRLRHLLHVAKARMYPKRLDDEQIAQINSGIDLSHLEGIYVPYLGIGDNGQGSVPITLEGEGEYMTTFAALSQLASNSHGESSRPELAGPPGSSGLSNDAANNWMYHSPGPSTSQPSGTPGPPPAPSAPTAMAESEKQGSSQRARRLGKRMASEVPGGAATPVAKRPRRQSNAGMGMFDVVNDDVGLDTGLDAEDEEAEGRVTEVLGHDAAFLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6V9</accession>
    <name>A0A1E3J6V9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031830.1">
        <property type="nucleotide sequence ID" value="XM_019176420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6V9"/>
    <dbReference type="GeneID" id="30193513"/>
    <dbReference type="OrthoDB" id="2564117at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="20859" checksum="DF3A8F274805E9A5" modified="2017-01-18" version="1">MSSASLVSTGLKAFACFWAALTFSVAAGFIAKTDDFFTLLGGSKYVRSTHLTAGNALIAAGVLAWLLVLTFVSPRNICVSVMVDTICLFALFVFFLGSSATLSTLASLARAYDTYTWAKLGEATLGIAWVMTFLILGILIFQVAYALLNFGGSYATWRSSFSQLVSRPEEVAPATPTTEKEAISAEAPVAAVPALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J706</accession>
    <name>A0A1E3J706_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031551.1">
        <property type="nucleotide sequence ID" value="XM_019176623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J706"/>
    <dbReference type="GeneID" id="30193718"/>
    <dbReference type="OrthoDB" id="10609427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="50507" checksum="6A8E9E0FE8D2E5A9" modified="2017-01-18" version="1">MSHDEHRRGSTLKESIGKQIDFLFQDTNHLIDGSSPPELTSVPAFSSDPKDPDSSFLHMEDSDDDNEDGSAAPLAHLPSPPPSPPKVIPTSKAECFVLQPVPEHMKFRKRKRLALGMEVAPRPRVSSRASSCSKIASWDIVDANDEHFVTLDMDDEDPSSPSSYNSDFTDSVFRLSPRMTWGPRPALSATCAPSTASTLEHPHSPTSVTDIIPHRPRGLARLRSTLPTHALKSFQCILAASDVLSKFCPDDMPAGSFYGFFDEDEWAWAFGDVNEESCKGAGRWDIRSGSTEKSRVGTYFAEPWLRTEFTNYPDHLSQLCHDHHTQVYQAHVSPADAQAVSPQTERVQTEVIASQAHVDRMTQELVGLLERARHYEKGAESDYDEDEEEESCLWEWEREAPVAWGCEREAPAVVWAFEKEAPVARAESECLGVDDLDEQKERKRLIDEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8K8</accession>
    <name>A0A1E3J8K8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Impact family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031662.1">
        <property type="nucleotide sequence ID" value="XM_019176252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8K8"/>
    <dbReference type="GeneID" id="30193343"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="69"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="445" mass="48581" checksum="84E856F44446FDC7" modified="2017-01-18" version="1">MSAVSSTSARPLSSALAQLSIDADARTEPDVRTPPITNPDPHGTLLKFIEHLLSEEHFDADSNLTAIGYELEALLSIYGDHSIKLALTPPSTAVATEVSSQAIKKSGSQQWSDAVWDAEIGFAPGERIRYEISLSLWEEGETLEGLDPSATPEISPTMRVLVSLAPTYPNSSAPQLQLLGKYLGSFAIDAGLFGDITRTYLSAGGAGFNPGDVCVFEGLTHVQSLARDWYAIHLSSGAAREAERNFHLTISQTHSPEESEDEDVAYLPRPSPRPTFSYTRGPDEAAPTQTMLRVEAGKDHGLKVWVSDEVVDRKSVFVGRAIKVTDEREVPLIVHGVLEDKRAARAAHPAIYAYRVVKDVGGTAQKVYMSDYDDDGESQAGGRLQHLLEILELENVLVIVTRWWGGHRLGADRFKHINRVARDALEIGGFLEDKKTDGKSKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J905</accession>
    <name>A0A1E3J905_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031952.1">
        <property type="nucleotide sequence ID" value="XM_019176039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J905"/>
    <dbReference type="GeneID" id="30193126"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="606"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="926" mass="101426" checksum="783E71D20B4DFD79" modified="2017-01-18" version="1">MAPKRQAPASPASPAKKAKGSSGNQQKTLASFFASPSKAKSSKPKDSEVITIDDSDDEERPIPATTKLAAVGEKSRKQGTSALGSEGARSVSDKISPQVNKLIDILDDEDEDIKPVPGCSKSTHPSKGKASISTQKKDAFSKTPVIASEAGNSVQPLNFDTDSFVFIPSSIDTALWPKGRLPYSILVGVYVQVSGTRSRLAIVRILTNFLHLVMHASPVDLSPSLYLLSNHLAPSYVPCDLGIGSQILSKAMQEVSGLQPRDLKRLYQKYGDPGDVAFEAKTNLRTLIKPAPLLAADVYEKLIGLSKIKGSSSGKVKGDIVRKLMVQARGEEVRFLVRSMIGNLRVSAFYKTTLLTALARATALLHLPKDLRSTILPLPVPTVDGKGKRSTKVKPETDPSREAAEQLCLSAIGVVRKAYVRHPNYAHLIKGLELGVEGLEERVAVTVGIPLSPMLGSITRSLNEVFTRLGKLPFTAEAKLDGQRVQCHVRLEGPQGKDDGGGRWVVGDTGDKIWVRLFSRHLDDMTEKYPDVCQLLLRLLKRTLPAERLPFPSSTLTEPQSVLDLLKTEKITSFIIDAEIVAIEKDTGAFKTFQELSNRAKKDVREEDIKVIVGVYAFDLMVLNDIPLLGSPFSHRRHLMRTFLPPLTPTKDSPQSSLIAAGFNHVESVDSTKFEDAPAELQAFFEKVVENKCEGLMVKLLESGEGLEGEDAEAEEEGETEVKRKSGNRKPLPATYEPDQRSQGWLKVKKDYLEGLGDSLDLVPIGAWWGNGRKAGWWSPILLACHNPESGALEAVCKCMSGFSDAFYKDLTKRYPAEGMPEKCNKTTPLGYIDTNGLTPDVWFDPSEVWEIRGADITLSPVYPAASSALGSERGLSVRFPRFMKIREDKTWEEATTSEQFADMYRKQMETKPEAAEGAGEEDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBN8</accession>
    <name>A0A1E3JBN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032126.1">
        <property type="nucleotide sequence ID" value="XM_019175636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBN8"/>
    <dbReference type="GeneID" id="30192720"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="67"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="538" mass="58805" checksum="1C1643FDD9E95548" modified="2017-01-18" version="1">MSTAFTDVDSKADITSAIHPVTSSSSSTHKDKATSLVVETENATFYESVSAAPLDPWSKTSFKLYGILLVAALNATSSGFDGSIFSSINAMTQYREYFHHTELGSSTGIIFMIYTIGNMVGSLFTGPICDHLGRRAGMATGAVIIMAAAAILTAAKNDSYLLGGRFLLGFGISIGTSSAPTYALELAPPQWRARIVGFYNTFFYTGSILSTGVAYASNKASGQLAFRLPLGLQLLPPFFILIGLPFIPESPRWLTARGKKEKAEEILAKYHGGGDVNHPVVQMELREFEEGIEVRKAQSWWNYYDLVDSHNQRWRFFMMACMSFFAQLSGNSVLTYYLPSMYTKLGITSVDRRLLLTFANSIVSCAGAVAGSATNDMIGRRTKLWVGSIALAAMFAGVTGFSSQFDGGKEVSQALSNGGVTFIFLFGCVYSFVYTPLTATYCAEVLANHTRAKGMGIHVIMSNCANLYNTYVTAVALEAIGWKYYLVFVGLNLVYAVIWYFFGVETRGRTLEELNTVFEAKWPPKEALQKAKVVVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBP7</accession>
    <name>A0A1E3JBP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032139.1">
        <property type="nucleotide sequence ID" value="XM_019175649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBP7"/>
    <dbReference type="GeneID" id="30192733"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN98277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="57" mass="6370" checksum="45AB7620CE4D33DF" modified="2017-01-18" version="1">MPVAPIVGKLRKRLITDLTAGLGLGTAGGYAFWYTVHLPMMKKRDDYYLKLEQARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU4</accession>
    <name>A0A1E3JBU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032181.1">
        <property type="nucleotide sequence ID" value="XM_019175691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU4"/>
    <dbReference type="GeneID" id="30192776"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="272" mass="30550" checksum="DBF3005AED3FA284" modified="2017-01-18" version="1">MRYAVLVTGPAGAGKSTFCASLITHAQTLGRSVHLVNLDPAADKFEYEPTIDIRDLINLEDVMEELEFGPNGGLIYCFEYLLNNLDWLDDELGAYEDDYLIIDCPGQIELYTHVPLLPRLATYLSTNLNFRTSAVYLIDSQFMQDKSKYFAGVMSAMSCMLSLGISMLCLMSKMDLVKDKKGRTKREVGRYLDPDPSLLYEDPSSNSNSKFSKLNRAVVGLIEDQNIVSFLPLDVTNEDSVNTVLSHIDNMMQYGEDEEPKVPKDMDDGDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFF5</accession>
    <name>A0A1E3JFF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032656.1">
        <property type="nucleotide sequence ID" value="XM_019175553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFF5"/>
    <dbReference type="GeneID" id="30192636"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="224" mass="24457" checksum="D7F7B2FEEE7B18C4" modified="2017-01-18" version="1">MSIAGKVFTKMLKTNLSKKGPDDPLYAFSVDAKGKQKRVIRDLPKGLSKRDQRALRKIRKRAHNLDKGMNLCGFRVGYTFFIGIIPGLGDAVDASLNYFLIVKPAKKLDIPDSLVHKMLFNNAISAGLGLVPVAGDIFLAAWKANSRNALLLEEYLTIRGQEYLASLHQDTSTISASEALAHGVPPEDLRELFAPGSGMEQRDVEEGAGSRGFFGKKNKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JH92</accession>
    <name>A0A1E3JH92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transformation/transcription domain-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032553.1">
        <property type="nucleotide sequence ID" value="XM_019175450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192533"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2516"/>
            <end position="3056"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3301"/>
            <end position="3629"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3630"/>
            <end position="3661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1948"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3081"/>
            <end position="3128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1948"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3107"/>
            <end position="3128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="3661" mass="414110" checksum="D0FA9A331133D9CB" modified="2017-01-18" version="1">MASSAPSTNRSGRPRKASTAASHPHPSETPTPSAAGGGATSMPPPSHTSNGPMSVSDCEFLASQLLEPSFPTRKKLEIALELRDSAENNRDFGFYDKYLSVFVPALISILGDEKSITFVKDNVEQRFRHTLFAFLQRLPHTEPFRHHMSSVMELCVKLLKIENEENALLCIKIMIDGLRSNKDQMEPYTEPFLDLVKQMYANIKAVVEKEFGTSGSGPKASAAQGEAAANGQSHTTLPHALHSPKVLTECPIAVVLIFQTYKSIMQTAMLDFYPLVIDSIKIQPEPQRLAHQEASEKGEIFVGVASGITNREMFAELVKAQVKTMAFLAYVLRGNQGNNRDYVNVFPEACARLLRDCPPEDVITRKELLVATRHILTVDSRSSFIPYIDILLEERVLVGTGVSSREMLRPLAYSVVADLIHHVRNELPLQQLIRVVYVFSCNLNDSTFSSSIQTMCAKLLNTIIDSIYHKADTNEMSRILKGMFFTFLEKLSAMSDAHERLKGLSVREKEKGKLKEKTEDEDVEVTNASEASADRLAHGWRDIEQAMPVHSVAYANESVETFCRDSRYLFKTILHTFRTLLSYTRQGDNPPPQPDGEVLSRFFECSLKCFAIFDGVNRDPREAKEALEMLSEIILLFEPHVFAEVWSSHMEFFSELSISNSQVFSLLQMVITHEAVSHQLVSILFKFLMAKLPKVGSMDKANSSLTLKMFKIAFLAINTYINSNESVLVPHLQKLIMSSFESAAKAEDSSFYYQILRALFRSIGGGRFEALYKEVLPILQEMLDHLAYLLDHPPDEVQSDIFVELMLTVPVRLTNLLPHLSYLMKPLVRALSAGPDLVSQGLRTLELCIDNLTADFLDPTLLPVLRDLMAALHQLLKPVPANREHANAALKILGKLGGRNRRFQEVYDSLEYQHLSDKITMPITFEGSHHQLELMSLVQTAGMAIDDDAEMLKEDGLQVLMYSALTVFEKGAPVAEGNATFLTTMTRLFIACDKPVVGEKASTFVRDVCRRAFALELGRADRKADGAEPTAKSALDHTRRRFLPLTNALSDAFLETLANSKTSERKGLSDLLATIVMVFKDLALSPRFASVVDGHRSFDRMVTFFALRLITLCHEEAWNKKMAGVAAISTFAHKIELSRKNIIDLELDFIRALLFCLRDAPQDVPRTADDVVELIKHLIRTCQSQEDGKPRLARITDTLVGELYSQSELARDAAHQCIEVLAEVTSQSVPDLITNIAKAKLLSVEHGPIYSKPLRALPFAMQVGNISAVTYLMNLRPSAVEATSEEFVRLLHEVLALADIDDANIITKPATHKQESWLKALRICCLRLLKSSMATPDFMNKPNQGQLRARIIQVYFKHVYSQNPEIVAVAHEGLRDVLQQENRLSRDVLQKGLRPILVNLADAKRLSVSGLDGLARFLELLTNYFKVEIGVKLLDHFKTLGDHQMLSKAAFAPLEDNHNIARMSRLVNIFRLLPASAIQYLNDLVANVVEVETILHQSQPGPFTEYLGRYLDRYHANAVQNLFDNVRNPRYVWTYRNIITSGEAPHLVEELANRAENLCQLCFGDTEAIDLVLPGLLLVRDLSRVQSSWLSDAEPVLEPMVGVWRMIVSKSRDSKADTTSYHFQQMPSLLLEMFMSSLEQQQHIPLLFHVVEAYEVRAAFERSHVTFFLYQQVALQESVDYRREVIEYFFNLYESEDVPWAYKTNALRVIVNPTLRVHFADPNHDQSLISPQLVQKIASLMWRPLAVITSSKQREDTHLIEVFALTTLLVQHCSSKVNEARKEIFKLAWMGINLLEPTVKLMAYVLAARFMATYDTPVKFVRLTWTGVLRLKDTDNRVLYRQAIDTLASSLSMRDPPPASGAPEWAKLLRTVLIEEGHATNQLVTVCELLVHHPDLFFDYRELYVPHIANSLGKLAFAQAATPELKKLTVDIVELIFNWEKRRMAAKESDAAEGEEGSKRGADPSSDQGTSKKLRIDRAGTAISVSSGGGWAAPSQVRELMTAHLLRLVSTSADPVTRNGLTKRALMLFKEILGPKGLPNVHVKLGFFHRTMIQASYSEINATTRPLVANSTEVIAAVAAAVKDTQWVKANLSLLSKLLEKVWVSHEVDLHEVVTSLTEDLFAEMPADETVEAEPDAKALLTFVQNAVNDGLAASLRSTLSLPGSLFLLRTWLKTHPKILQSEGISIALLKVLGNTVKLHTTTNQAAGAANEPDLVRLIISVLDILRDRVPDLREHRKTLYLGVTSLIDKSANLTLCRYLLQLMRHWIIEGPDAAVHGKEKASILLRMMNFENKNDVLFQEYLDVVYDIYEQDELRGSDITHRLEPAFLLGTRSRKPEQRAKFLDKLENNLPRSLEQRLQYLCSLQNWDTLSDGYWIPQILSQLLGIVDVDEALIQVPFTQVLDSDSVLDLSETATVGHIIRPARNLIHIDPKLSHDLWVGIFSMCWESLSRSQQMTFTPYLIKLLSKSHLQKQTDMRPNVVQTFLDSLAACTVPVTLPPTLIRFLAKNFNAWYVGFELLTRLTDVYRGDDGLRETCASCLSELYAELCEEDMYYGVARSRCQFPETTGALTFEQNGMWPKAVELYEQAQIKARNNMLPFSEGEYCLWEDHWILSAQKLQNWENLTELARIDNDSDLLLECAWRLSDWASSDRLAIDENLSRVVDHPTPRRKTFEAFLALLKAQNNRDPPNEFLRVLDEAQQITLRKWISLPAHMTSAHLPLLQMCQQCVELGEAARVFDSLQMTNQTNLELRCNSDLKPIFQTWRDRLPNFWDDISVWSDLLAWRQHIFQAVTKVYHPLVAQPDNATYGYRGFHETAWMINRFGEVARRHGLLDVCSVSLNKIYMLPNIEISEAFLKLREQALCFFQKPEKFNEGLENISTTNLKFFGQPQRAEFLTFKGMFIARLGQNEEANAEFAHAIQTDWNLPKAWAEWGRFNDKLYKDRPEVPTTDRSVLASSAVSCYLQAAGLYNNHKSRGLLLRVLWLLGLDDSHSTISKAFENYKGDLVIWYWITLIPQLIMSLSHREATHARLILIRIAKAFPQALFFPLRVSREDFVTVKKQQQLHQKYVAARQAKAATANAADGSQTAEKDVKEEPAASGADANGSQPPASGSMPPPSQSQSQAPRQPWDLVDEIMNLLKTAFPLLALTMEKMVDQISVRAKPASDEDIYRFFSALLADAMQQWGARSGLHNDDGELNAQTKDNLAKFATNLNGDLKVMIEKDFMADMPKLREYIRLLQRWRDVYEGNLDDRSKTLPLDQGGCTLIEFNHSKFDDVEIPGQYVKHVDQSEEFIKIARFAPKAELGRGHGYCFRRITMIGNNGQSYTFHVQMPAARHCRREERLTQLFRIMNSVLWKRKESRRRGLQIHLPTATPLAPQLRLVQSDSSYVSMQEIFEDYAASKKMAREETVLTYYDRLKELHDPSIPRNDHRYIQLRAELMEEIRVKMVPETIITNYMMKSMNGPDNLWLMRKQFAAQTAATMFLTYVCCLSNRTPSRFYVSRKTGLMYMSEILPAFAPGQPLISSSESVPFRLTPNMQNFVTRAGVEGIITGTCTAMARCLTSPEFDLSGTLCLFIRDELLIWHNTYLKDSRLDKPLLGHVYRNVDSFIRRVSTMGYIGENRDRSTSAPPVVHAIVSLISQATSAINLAQMGEIYMPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHS7</accession>
    <name>A0A1E3JHS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032548.1">
        <property type="nucleotide sequence ID" value="XM_019175445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHS7"/>
    <dbReference type="GeneID" id="30192528"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="42990" checksum="E1357994AF6C7941" modified="2017-01-18" version="1">MVFPFRAKTANTPPPPPLATDNNMPPPHPSAIENHVSPSTGPPPRYTAVVRRVYPYTLRPIVIFVSIVGFIYGIALGVESIKGRNDDGETSKMKVFDIIEAIMFFVIAGTELFVLAVAIMQSLQLARLFIVLVPVGVLVNLAVSIVSIIVHFTLKSDLISQCVTNEEGDSFSDSWSGSSFNVTNTQANTICNNSWNRGTWGVFAWLLITLGISLLFASTYFSYYHQLLDPTSVRERQNYRQNQNQAFPMQSSYPPPPDGQQAWMVPPYPGPPAPPGHYANNPPPPAGYEKSDYHPGAEWAQGDYAPPAGAPPRERDIGENRAEEEAWDRARSQGVTAHLTGHGFAPRRSSDSLNGGYAIPNAEEDEAWERARNEGVTSHLTGNKRNGERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI39</accession>
    <name>A0A1E3JI39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032743.1">
        <property type="nucleotide sequence ID" value="XM_019175011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI39"/>
    <dbReference type="GeneID" id="30192083"/>
    <dbReference type="OrthoDB" id="10376731at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="127" mass="14534" checksum="FAB7346612C10F55" modified="2017-01-18" version="1">MSPSAPTFDLQSLFPLPNDITRLILDAYASSLPTQSSAFLDFICLNRHTYSRYLTWIYHTIERTHDNHLSFFESYGNVFQEFTFASYDEPEGSDTSFFAPSSNLSARQGDRAKKVRKVIAFHHSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIN4</accession>
    <name>A0A1E3JIN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032936.1">
        <property type="nucleotide sequence ID" value="XM_019175204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIN4"/>
    <dbReference type="GeneID" id="30192283"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="549" mass="59682" checksum="6DDC18CB0D43C50C" modified="2017-01-18" version="1">MVAVPAQWQEVSRAKIAARDALIPKEWIIPATDARSVIHIPRTCGVLSDKEIGITETPATALVESMLSRELTSYEVTLAFCKRAAIAQQLTNCLTEIFFETALRAARAIDDNYAQTNTPLGPLHGLPVSIKDNFYVEGVDTTVGFISWANDPAKKEQESEITKVMRECGAVLFCKTNVPTAMMIAESYNNVWGYTSNPYNTSCSSGGSSGGESALLALFGSPLGIGTDIGGSIRIPASMCGLYSIKASFGRFPTYGARSGLPGQEAIRSINGPLSSTLEGVEIWAKSVVGKKPWERDPNMLPIPWREYEAPSQLCFAIILDNGIVKPTPPVTRALQETKAALEKAGHKVIEWSPYNAEQATSLVSRFFLGDGGVKINQILAAGEEPYPEGLAAYKARFEALKNDPPLVGDLWDLQAERTSYCKKALDHWLASKDVTGTGRPFDAVISPVTQHSACPKKAYGGHVTYTSMWNITDYSATTFPVGFVDSAVDKKEECEPRNDVEKSVWDRYDPEEVSGAPISLQLVCQRLEEEKAIALTGVVAKALKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JK90</accession>
    <name>A0A1E3JK90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032729.1">
        <property type="nucleotide sequence ID" value="XM_019174997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JK90"/>
    <dbReference type="GeneID" id="30192069"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="125" mass="13406" checksum="513A9F04E3E55884" modified="2017-01-18" version="1">MLPGIRTNTHTNAAATLRITITALPFFVRSHYASKLHSHYASNWTLTVSTTDLPHLPHYSSTSPPFLSLLMPPPKKGSKPKATPTSTKGAPSTKGKAGTKGTDKSKTEKGKDGKPKDGQANKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKX6</accession>
    <name>A0A1E3JKX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032774.1">
        <property type="nucleotide sequence ID" value="XM_019175042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKX6"/>
    <dbReference type="GeneID" id="30192115"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="23181" checksum="8787C3FE2D629CFE" modified="2017-01-18" version="1">MATATPPCPIVVDTDGSAYIPLPDHPGLRLAPGQTTDLDALVKLYNTPEIGKWFWRRPFPCPAEEISKTLEKVPVQQAYLATLISSLPTSPAPLIPYTDNICPFNTLRESDTGKLLGTVFLGPSKAEGDWRIAYDLMPEVWGKGVGSAAAKAAVDYLRWFGAKRVTGVHEPGNGASGAVLRKAGFSRVKDKELEWPEEKGGGHRLVHVWEATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM67</accession>
    <name>A0A1E3JM67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033165.1">
        <property type="nucleotide sequence ID" value="XM_019174786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM67"/>
    <dbReference type="GeneID" id="30191855"/>
    <dbReference type="OrthoDB" id="10400740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12579" checksum="0E1EFD7B6C9BCECA" modified="2017-01-18" version="1">MRDNMQMINGRGHAFDSLQDRTGTFFSPSLLWKKIPSLMIVPELIAELEAAAQHVKPVRKDHLVKQYYCKNCDAPWAKSPEAPHDHETWCIRCNAVLVDKGHKIDLSVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM96</accession>
    <name>A0A1E3JM96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent helicase STH1/SNF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033232.1">
        <property type="nucleotide sequence ID" value="XM_019174853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191924"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000104">
        <property type="entry name" value="Probable SNF2-component of SWI/SNF global transcription activator complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="15">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="364"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="563"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="873"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1267"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1357"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1409"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO01980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1425" mass="161373" checksum="E481880EDA0544DF" modified="2017-01-18" version="1">MQDQNQDAVVSQPPQPPKPGAISLDDERTLEMFENMDVTRLNNIRKRATELQTAGQTRESSSELGKLLTILDMYARAKQIKHDRALAANKPTEDGTSAPATPVSAPNSAHISMNPSQIAQLRTQAAAYQSLSKGQPIPDFLLSAAQGNPPPGVAGQPPVPQEQEGVAAKVVDKVVETVVEDNLEAKEKDGRLEEQPYLMEYDESSIIYPYNAYVDPSIYAKRRFDDEVTNPLHKRQRLITPAIMPRGLDPYLLMEERNRYIETRMAWRMKELEDLDSTAGLGTAGAQDVPNIAEAEKSNSNLGIQARIELMSLRLVGKQRLLREDAVRAMHGATQVPADRSQFRRFRTHTLRDARATETAERRQRTEREQRGKQRHMSYIHSICDHGQNLIGAGVGSLRGQGSDKMKRLGRSMLKLHADTEREEQKRIERIAKERLKALRNDDEEAYLALLGEAKDSRISHLMDQTDQYLETLAAAVIEQQNDDVHRDAIISEPFEVEDGPANEEMFGARRQDGEEAGAERRAGKVDYYAVAHKTQEKVTKQADLLTGGTLKDYQVKGLQWMISLYNNRLNGILADEMGLGKTIQTISLITYLIEKKRQPGPFLVIVPLSTLTNWTLEFERWAPAVRTLILKGSPAVRREAYPRLRAMDFQVCLTTYEYIIKEKPLLSRIKWVHMIIDEGHRMKNVKSKLSQTLNEHYSSRYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGEKMEMNEEEALLVIKRLHKVLRPFLLRRLKKDVESELPDKVEKVLYTKMSSLQWKLYESVQKYKTLPTDMTAAKPQKRQNLQNALMQLRKICNHPYVFREVDEDFSVGQSTDEQIIRVAGKFELLDRILPKLFGTGHKVLIFFQMTEIMTIVSDFFEFRGWKYCRLDGSTKAEDRQALLSTFNDPNSPYQVFILSTRAGGLGLNLQSADTVIIYDTDWNPHADLQAQDRAHRIGQKKEVRVLRLISSGTVEELVLARAQRKLEIDGKVIQAGKFDDVTTGAEYEALLQKAFEASNEEDQDETNELDDDELNELLARGDHELEIFAQMDKERNERKLAAWRASGHTEDLPPVLMAESELPPFYRRDIGQEMAAQVANEDEQGRGRRTKTDVRYNDGLTDDQFLAALEDSDDDVEDASDRKKKRSDKKAERKRVNDMLARAEADGRPLDASALRGEVAEPPLAASSGGKKKRARPSTSVTPSVTGDDVPSKKRKTDKIHSAEVQLMTRLLSDVNNLKSELGEDLNQFFLVPVNRKDYPDYYKIIAQPIAMSQIKAKVGKPSYNLQSLYNDLHLLWNNARTYNQEGSWVYNAAEDMQEGFDRMWEEQVPPFLASQGGENGGSSYGDTSGAPSGSSTPMFKSVGEKATAPKIRISMAKKQVEAAMDEDSDEEDDDDEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMB5</accession>
    <name>A0A1E3JMB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033252.1">
        <property type="nucleotide sequence ID" value="XM_019174873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMB5"/>
    <dbReference type="GeneID" id="30191944"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40252" checksum="35FF834D4AEC4DC6" modified="2017-01-18" version="1">MSLYKILVGGYRSVYEIFSFEPSTSKVKLAGSSPALIKPTWIELPGPPINKGNSEERYLYTVSDVDGGSAVSLKLNGDDIEITGQRQCYGGAVHIHVMKDGSGIILSNFSGGSAIFFPIDSNGALSKTSESPLLKLPFVYEGQTAPNSKRQEACHAHNVVEGLDGKLYLSDLGTDRIWIIKREGESGLSIDGWLQAPPGSGPRHSLISEDGKFLYNLTEVSNDILIFPLDSTAEHPEPLPSKVSVIPPSVPSDPAAQAHMNAAQLFFNPAHPGLLYASNRLELTLPSEFATGEQGDAVAIVKLNAAGDELGEVKWVRTGCNNLRGMRVSPDGKYVVVAGRVGGGLEIWSTGQDGTDWKLAGKDETIDLVTDMTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JME4</accession>
    <name>A0A1E3JME4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 (Mitochondrial carnitine/acylcarnitine transporter), member 20/29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033282.1">
        <property type="nucleotide sequence ID" value="XM_019174903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JME4"/>
    <dbReference type="GeneID" id="30191974"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO02030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="344" mass="38152" checksum="2F1A6EDB73267926" modified="2017-01-18" version="1">MGSHSDHRVPEEISDPDIYGDGPQEVEQATPEVKEHSPYIGFAAGICSGWTKLIVGHPFDTCKIRLQCAPPGTYKGVWDVLSSTVTKEGPRALYKGASIPAISWGITDSILMGSLHNYRAFLLTHGFGERNPGSEEQRLSILGHTTAGLFAGWTNAIPAHATELIKGKLQLQMIQPENTPKEFSGPIDVVRKTVAEQGITGMWRGLGSSFLYRSCFLAMFGSFEAFNRLFKSWDGTSWEMSSGMANFMAGGMGSNVYWLAALPMDNIKNRIMTDDIKRPRYKGVFDAYKQVWRETFDPSKSFGWNSAARVRNFYKGFTPVVLRAFPTNAAALAVWEGVMRWQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRB2</accession>
    <name>A0A1E3JRB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033470.1">
        <property type="nucleotide sequence ID" value="XM_019174418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRB2"/>
    <dbReference type="GeneID" id="30191479"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="216" mass="24698" checksum="F883F43A9E86E2E6" modified="2017-01-18" version="1">MGRRPARCYRYCKNKPYPKSRYNRGVPDPKIRIFDLGRKKASVDDFPFCCHLVSDEYEQLSSEALEAARICANKYIVKTAGKEAFHMRVRVHPFHVVRINKMLSCAGADRLQQGMRGAWGKPYGSVARVNIGQVIMSIRCKDSNRAVIMEALRRARYKFPGRQKIIVSKKWGFTPLARADYEALKANKQVINDGAYVQFLKPKGSLLQNLRTAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRH9</accession>
    <name>A0A1E3JRH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033532.1">
        <property type="nucleotide sequence ID" value="XM_019174480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRH9"/>
    <dbReference type="GeneID" id="30191541"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16660" checksum="36C42E99BB3A3B2C" modified="2017-01-18" version="1">MTVNLSYYAIPLVHLQTLFASLRGATIRLGFPNNVAPREVISEMEKSGKVKPHTIAKLKRRQAAHENCFENMGSFIGAVVAGNTVGLSTTWMNAMSITYFSLRCLYIWLYLNVTEQKKSYFRSVVYWGCNFCFLATYVKAGLKLNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTD8</accession>
    <name>A0A1E3JTD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033418.1">
        <property type="nucleotide sequence ID" value="XM_019174366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTD8"/>
    <dbReference type="GeneID" id="30191426"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="368" mass="40228" checksum="923DC2211E0EC868" modified="2017-01-18" version="1">MAGPPVMHHPDCLLEPAQYARRFLTALLGVPLATGDMKEGDTQGTLTLHFHENKDKDGNPSNRVFGVSSCHVLRKDTHNDYEQRGIFAPKEYVRMCSLRRFRHGLYEITDKITEHSFSARSLALQVAALQGKEGLDEEGARSLRWCLFRLGNEHEALTGLEALYHEIKSDWSDIKHADRTIGCIQHAKAVKVDQDGPCFTLDWAAFQVSEAKFGNQFEGNVATDDDKQGKRCFTVGKDGTTTGLKNGAGTESIELGIYDSGVRFARAFSGLGDSGALVWHIRDGKTKIVRQIRSGQNKGGSTRNYITYSTLGSSRSESASSMPTFTVPAGLLEGGPGGFKILPPLPAPCSCAKLLDIQVTYMGDMGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUM3</accession>
    <name>A0A1E3JUM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033683.1">
        <property type="nucleotide sequence ID" value="XM_019174631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUM3"/>
    <dbReference type="GeneID" id="30191696"/>
    <dbReference type="OrthoDB" id="2561841at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="43086" checksum="7EB72FAF3F0366FD" modified="2017-01-18" version="1">MSSITPADFAALHLVHHLILDQLIASAPHSALRLCSAVYTRAIPVLYREIYSSPAVFRGLQLQAGYERTVKALAHTKTIIVGGFDSIDTLYALAGPRPEKPPDPSLSPCSSSCSSSSSSPPSSPPSSPPSSPVAACPCYPRRYFGLFPNLDRLEFTSFAVESGYIAYLNRLDGPEGHDHEPLLWQRLCFQLPNDVREMIFVLDNDSRNHWFEVEQHIMFQRPHKAVVFIRETVKTAAQVAESGESFARLGEQLPSLWSNAKRLTVFVDTNEALDWSDHEQVRRYAIPMGKALSKFAQRFAMIVSSWRWEWALGDEGDLDRKLVDHIQIHIPLVGKVLEEMSEEGRKQVDQLVMNGRLVLGEYEGWMVDDLHVMERRQDGISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW91</accession>
    <name>A0A1E3JW91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033783.1">
        <property type="nucleotide sequence ID" value="XM_019173976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW91"/>
    <dbReference type="GeneID" id="30191029"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO05128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="204" mass="23016" checksum="6FE43FCCCD233D5E" modified="2017-01-18" version="1">MTLYYSICFALLMAELGLFCTIVCPMPFALRKKMFHFLSENPIVSRVAGGLKITFIFVAVLFVDALQRMVRIAQEGATAKMKSDISDVRAETNYAARRFYAQRNLYLTGATLFLSLLLARVFYIILDFITVQESYTALQAKTAKGSGASGEETEQLRLRVQELEAKERDFETLKKQANQQNTEYGRLADEHNKATGAVSNKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWI9</accession>
    <name>A0A1E3JWI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033818.1">
        <property type="nucleotide sequence ID" value="XM_019174011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWI9"/>
    <dbReference type="GeneID" id="30191064"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="462"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="826" mass="94726" checksum="90E2237C2F3AA6A0" modified="2017-01-18" version="1">MDTRSASPRVPYRAASTPPPNYRGLHSHSPARHHRSSRPGTAGSEYPEQPTAYRPLQEEGHAKPSPFALGQAPPAKWRLPKAVRSPKRLLSTLVALAILGLLIKYVGMGKDRLLRSKWGWRPRGGRRVDDGLCRFVSPVDAYHRDLQRLRGLAYPGANLTALYPSLHSYVHHHTYSPTGHLLVSDHPDAPHPIPLLLDLGEKRWEELLSRQSRTLEEAVREYMRRYGRRPPRGFDKWWDFAMRHNLVLPDEYDRINLDLAPFLALPEEEMKRRRGLVDNMSETFTLVIKNGSVDIEIKDEGGLNWGGTLPRASDTAALLRAFSEHLPDMRATFSIFDQPQIYLSWARRGSLVNLGLKGEHTSHLEETDSALVKLSRSCAPDSNYRKNESYSEGRSFIYDSLEAGDLCQNPYVIPIHGLTIEPHEPSSHPRPHTQLLPLFSLAKTSINSDILITPLDQFNHETGKDLEFRDKPSSRLAWRGSPTGISWMNAQVDWRNAHRIRLHRYANNRSTEHMTFLVPDFGQDEDYYPDEFDVDGGIAEIKNGQEEWHERNREVQEQHLEEQIDEGPLHFIEEEIPTDEAMEFFYDIKLAGDPIQCDSDDGTCDDLRREIEWAPRQSGEDLNQNKFLLDIDGNGWSGRFRKLMSTNSAVIKMTMFTEWFQPHLIPWFMYIPAKLDFSDLPDIMAFFRGSPTYPEFAFDETAEALAINGKCFVQRMFRLEDMQAYMMRLFLEYARIAADEGDDMDFYLDDYWSDIDTSDWFDEEAIKNRKPVADLPDVMEGDGGSRAAGTVLEEELVEGTKQDDGGDISWEEHDGLSEEELLREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT4</accession>
    <name>A0A1E3JWT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033983.1">
        <property type="nucleotide sequence ID" value="XM_019174176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT4"/>
    <dbReference type="GeneID" id="30191234"/>
    <dbReference type="OrthoDB" id="10324443at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="820" mass="89701" checksum="CAA0A1311C64237D" modified="2017-01-18" version="1">MAQHNHDGFAFPHPLNLGEGFTHMSQAGPERTLKPTRRPQQSTLSLLNARMDGMDARLDNLRKAVGGLKESMAPLLSKAEFESAIEEWEYGIATANFKTHTELQNLNKLLVGSMDLQMDERGMVSAQVLERLQNNLLRRFDKVERCLGESPSLPDQGYDSYDILEERVIELEEQLRAEKAENKEVLKRIEDLIFTSESARQESHAMMMGRLTYSDSLLKYIVQTAPARSNQPTQTRLPPPSSFVPPQTGISYDTAYGLHSQAQAQEPRPLPPVPVQASQANAVFANYSRPFTAQYVTPIPGTNLPPATQSVSEAVWSLPIDPKAYASVRSNPANPESVPTSSTLDSPVPAIAVSKPAGVVPAAIAPTPQAHETTSASPASPQPTTMPGKTIPLPAIPVHKPTSMEPLGWPHAPHLYARKVMPAYASLFDPMPPGLPAASELQSQTEDKADEVMKDGAAGGKTDKSSENDTSETKTPAQIVFSMPAYTHNLGSFRDRQHKEPVSSVFGFDSEEFTRQYKERLMAEMPESVKLEPSDLSKYTARIIQPKGMSESTHQIPRKPAPANIPEGWTDVSRDMSENQEGFAPDDVEMGDEVDASEEDMSETATLASADSDEGFVAVHNEEVALSEPMLGTELVEDHIGAYDRPLAATQGDEHSESWDFSSECSDTGDELLSWTPPPAAHRSLIGLLSTLSFAIEITISDAPADDATSPDGATPDSARVESLKTILAWSSTLMETTVSDSEWGYYTLRLLMDMAKHSTRWPQDREQLDLESGIDEIKEYMTRVVGLDGKPIAHKSHEGTEDGKIQVVNVVDKYGVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX20</accession>
    <name>A0A1E3JX20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034073.1">
        <property type="nucleotide sequence ID" value="XM_019174266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX20"/>
    <dbReference type="GeneID" id="30191324"/>
    <dbReference type="OrthoDB" id="10373088at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="403" mass="44892" checksum="1684C6458432EDBB" modified="2017-01-18" version="1">MDADIDGTTSAPLRTHSPPSTTPTVSPSKTSEPSSREIALQTQINSLQSELDNALFSNISVRHSLSEAQSTIKNLESMVTKYHVEKGEKERAERRGRALEMQVDRLEWKIEQLKNEMKTKETECRALEEGKEWETKYRALKRGIDALSGGSGSPSKSKHNTQMPNKKLRVSLGLDHPTPLTPPHKPKPTKPSYRRHSVPSARALVQYDDIPEISDAESSGGQDDDVKDDNFVYYGDDVEVDSKKAKRVPGGWITSQKENTARLLASFNSAHRQALSLRPLRSPKSEFAQLSWKKERLAELMVRFVNLPGSAVDESELGKPGGQKLDLIKRMKDALDQGLVYFEAVPPPESVETRDVGETEAANVWKTAVEKDMSEEKETEEKETDEGKDVGEGSDTAKEKHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX52</accession>
    <name>A0A1E3JX52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033991.1">
        <property type="nucleotide sequence ID" value="XM_019174184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX52"/>
    <dbReference type="GeneID" id="30191242"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130658" description="ER membrane protein complex subunit 10" evidence="9">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="223" mass="23278" checksum="2CD4F1D6912BE0E4" modified="2017-01-18" version="1">MLLSATIPALLVAPLALASQQYPVYQRLLPQSSSPSTASLSSFESIGSISIPDEASGLVGKLSLSVGEQSAGNEVEDDGTGWYQVGVQLEEGDDEGEWLIASTRSCYLSAPPVVKVQVNGTRPLSISVHSSDPKSNTCGTKSVVKTPKDLSSVIFETSRTAKTVLPLLGAPPVVDTTGTPVVPPPEKGFLQKYWMYIVGLALFFAVQMGPDEPREGGGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYT1</accession>
    <name>A0A1E3JYT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034022.1">
        <property type="nucleotide sequence ID" value="XM_019174215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYT1"/>
    <dbReference type="GeneID" id="30191273"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="3">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="22871" checksum="2D4BA344F931DCCA" modified="2017-01-18" version="1">MPTATATTPTLPANPPQAWAKPTLSNTYGGKTYEATHPQLFAVEFTAGKGLEEGYASRLVAVRNYSPGEVITPLTNISLAPEKAYSSVQFGPGPRDHLELNSDLLFMNHSCSPTAQVHLPPDQSQWAVHASSHGNGIKKGDALTFFYPSTEWDMAQGFECACGSDNCLGQVYGAKHIPVEELKKRSFINEHILALKEGQQGSGVVGARGLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYT6</accession>
    <name>A0A1E3JYT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034164.1">
        <property type="nucleotide sequence ID" value="XM_019173459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYT6"/>
    <dbReference type="GeneID" id="30190506"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="40934" checksum="8972AA0741A80835" modified="2017-01-18" version="1">MSKAHPEIKNTHASPPSCHDIAPLAVLPEELPNRVYSFLCVNTRRAQTLIVARLPKSHHHRFIPDLYERLQVTEEILDRGFFKGLLNGVDDDAEGGSRSTRRRALALQRDLLGYCKSVVNTSLYAWAAIKDAIKPATSPPIGRPAVPTSTFSIPSPLPSSTDREEEPHTASHGAGDATETNASTPTPYDPGHQTQPAADQPPPSRPAVDRGQSSSAAPPPLLTYKPLYRCNNPSDNAHSDFNVPQSAATSASHHPWLTDSSANNRPPLPLDDPSSSTSPTSMLRAAPTPTLKPPGSINPNQVPWGGGQQGQAGGGRERPFLGGAADEEVESVEESGDDNNGENGEEERLHRQTTSEASSASTPSSNATDAAFEQNRLMPRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ98</accession>
    <name>A0A1E3JZ98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO acetyl-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034280.1">
        <property type="nucleotide sequence ID" value="XM_019173575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ98"/>
    <dbReference type="GeneID" id="30190625"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="2">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="51029" checksum="F5D0613D0D8372CA" modified="2017-01-18" version="1">MSSRCVPPHPSPSLKLTIPRPVVRKTYGKAPPRSSSTVSLFDASPPPTPSLAGPSSSAYRSSSPSFDRLDSPLGSSPPRAVRERDGTPLFFSCDEEEEETRQSRDGLVKEQSVKAKAKAPVKVVKKAETQSSLKGFFAPLPKPKKRPLEPSPANSSPSPSSNSPSSMLGLSRPATITKFIKTPTPTPSAPGKENKSTTRKPVQMRLTHLPLLHTCPQCGMSFMRGGEDEAVHRVHHTRVLRGIVWEGVKVKGKGREEGWRVVADDVEFGEGKGKGRGRVVVVDGSVGGPKINEILSTVDLVLSAPALPPPILAQCKIFLFLTSSPPPPPSESTAKRQKLDPTLRQANKDGRERVISVVVAQGIKWAMRVLKDGEGVDKKVVETGGFGSVSCEPTHLPTPLGIHRLYTIPSYRSHHLSTHLLNAACAHTVYGCELDPKKGQVAFSQPTESGRKMMERWGGGEVRVFVDDESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZE2</accession>
    <name>A0A1E3JZE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034256.1">
        <property type="nucleotide sequence ID" value="XM_019173551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZE2"/>
    <dbReference type="GeneID" id="30190601"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="525" mass="56761" checksum="70674902E359406F" modified="2017-01-18" version="1">MASPDPALLANLRSLYAAADQSHVFTFYDSLPPAEQASLLAQLESIDVARVNRIFANAVAAAAAITPAKENVNLLEQSPTVHKGEGENGNLVGNGPEDTEAKPLPEEATATVLNNPEEEAKWRAQGLEAIANNQVAVLLLAGGQGTRLGSALPKGMYDIQLPSGKTLFEYQAKRIGKIENLAEETYKKEKGSVRVRWYVMTSGPTRQATEKYFRESGFFGLREQDVIFFEQGVLPAFSNEGKLLLSGPSSLSVAPDGNGGLYAALRRPLSPSSPTTVLSDLRDRNIQYIHGYCVDNCLVRVADPVFIGCCLSRKAAVGAKVVRKEYPEESVGVLAAKGDAFAVVEYSELSKEKAEQRTADGQLAFRAANIVNHFYTVDFLESVEEMEKDMAFHIARKKIPTVDLSSGAAIKPTEPNGMKLELFIFDVFPFTKSLCVLEVDRAEEFSPLKNAPGSKADCPETSRRDLLAQQKRWLQAAGAEVAEGVEVEVSPEVSYAGEGLEWVKGVKIMKSGVLSGKGGLAELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZI8</accession>
    <name>A0A1E3JZI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CMGC/DYRK/YAK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033977.1">
        <property type="nucleotide sequence ID" value="XM_019174170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191228"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="504"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="829"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="903"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="903"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="956"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1171"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1291" mass="140580" checksum="661283964553B95D" modified="2017-01-18" version="1">MSRPASYSDHYVDQDTLPLFNQPPPPVPASHPYSPYSPSARRPPPMATNRPPSQHSHLPYVQHPQEQRARDNSDLMPSATDYLARSTSLGRKKDPFAYRSDDVESGFGSMDIMDGQGQQGQQGFTFPAQREAVASPGSGTYAQMNPPPVPAHIITGRQATLPDHPSPTATTHAQQPVTPSSYTHPHNPYIPSRSSDPGPSAGAVSTAPPPVDPYHPSAAGGAQWTDYRRPSQTRMASTSSFASHGSGGLSPYLTAKDVHEQSPLHSPLLNPYDAASPTSQSHWSTSPAIHAPPQNNQPPQAPSSPRYNAGSRPQASPVGGRPPPVGSRPISTAYTPSLNPSTQLYPSSQPVTPAGKYDPSMPPPKIFPPRTASGASSLSTGTGTTGSGMMSRSTSAGAGSEDGFREVKGWSDLRAVVNSQPNGRRADPDCPGKWLSPLKCLTTGLAETYTLSNPNFRYVTSDNPRRVLTKPSKPAHNDGADNEDWDYILYVNDVLGGEDGRDRYIILDVLGQGTFGQVVKCQNMRTHEICAVKVVKNKPAYLQQSKMEVAILELLNTQHDPQDQHHILRMQDSFTHKHHLCLVFECLSSNLYELIKQNQFKGLSTQLVKVFTQQLLDCMAVLKEARLIHCDLKPENILLKSLQSPQIKVIDFGSACHEMQTVYTYIQSRFYRSPEVLLGLPYSTSIDMWSLGCIVVELFLGLPLFPGTSEYNQVSRIVDMLGNPPTHLLEVGKQTHEFFNRTTDGYGRNVYKLKPMQQYAVEHRTDEQPSKQYFKQTKLKDIIMEYPMGKKTDVNKEIATRKSFVDFAEGLLNMDPIKRWSPQQAMKHPFITGDKWTGPWQPDATTTAKKPDPSPEIPQPPSSSSSTPNKKYGGLVQTPQSSRSQRVYSDAAAYNHQLAQHQSYTASVQQQQQAAQEAASRGPFSPGYQLSPGQSVSAGYGHQRVDSQQLPPAHQQPPMQSGRRSRQSQSGQWSMPPPQGYQQQRMPSLSGSASHASLRAAQQPPPPPSIVSNPPPNSYYPSSRTRANTINQMDAIPPALARLVHFGAQDPNGSRNTLTPVMNRDEAIREWERRHQGGMGHNKQNSIAGPAYQQLEYLQEQAELAAMQGQNWMPYPPHSGHHQPPQGHHPQHGGGHHRQNPSGQYQMQPHIGISPPNPSDYRPRPTSDYDPPLSAPSSAGGSGSNRNSATAQGYGLPTYPPVAAITGGSSAGGTGQSFDAFDQRDGGMGMMYTPLQPTQVFGYQQSAQPGPGQGPGPGHGGGHGGGHVARSSYSGGYGSGNPFGQPNSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZT1</accession>
    <name>A0A1E3JZT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034406.1">
        <property type="nucleotide sequence ID" value="XM_019173701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZT1"/>
    <dbReference type="GeneID" id="30190751"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="177" mass="19812" checksum="41288F3CAED07C58" modified="2017-01-18" version="1">MTMAKYLFATFDVTAQVFYRSTLSFGIVNLKPLLPGHVLICPKRVVPRLADLNTEEVSDLFQSVQHVGKVLEEVYKAQALTVSVQDGAVAGQSVPHVHVHIMPRHPTDYNGDNDQIYPLLEQSEANLQGHLAQSQVPQVNGKTEGKGREGRWACDEDRKPRTMGEMEREAKWLASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZW4</accession>
    <name>A0A1E3JZW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034097.1">
        <property type="nucleotide sequence ID" value="XM_019174290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZW4"/>
    <dbReference type="GeneID" id="30191348"/>
    <dbReference type="OrthoDB" id="2564982at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="263" mass="28428" checksum="DB0199C9C5D3E3AD" modified="2017-01-18" version="1">MAPILYTLLKRDDSDSTDSSSDSSSSDGSDSSDSFSSSGSFLDEHGKQIYIALTILSILLLSLLLFLYSKHRLAFPPFNQKRCAVCKHGIAKSQKVDEDYFKNDDDDDDGGGKGGGGGKGGGGGGGGGGGGKGKGKGWICRKCQEEREDEALEEELEKEGLGSGSGKKRKSKGVSEGGGRSKGRRDEEGETEREKEGKATSKRREGKGSKRGEREEKGRGQRETREEDEDLQSPPTKNDRRPSKAREEKSRKAQVESDSESDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1M2</accession>
    <name>A0A1E3K1M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_01323</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034192.1">
        <property type="nucleotide sequence ID" value="XM_019173487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190536"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1893"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2559"/>
            <end position="2709"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2901"/>
            <end position="3067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="4309"/>
            <end position="4329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3163"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3381"/>
            <end position="3429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO06092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="4599" mass="519589" checksum="BC654DC92D00263A" modified="2017-01-18" version="1">[encoded data, 4599 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K285</accession>
    <name>A0A1E3K285_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034727.1">
        <property type="nucleotide sequence ID" value="XM_019173001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K285"/>
    <dbReference type="GeneID" id="30190042"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="364"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="647" mass="73768" checksum="5F31602149828611" modified="2017-01-18" version="1">MPIHIPKRALRSGITIVLFFLGPIIILGHLASLSNHTDEHERWHAVFKEDHSEAGWKDAEGLSLQESNDYWYDELEFEDEEREGRGSRVKHGKPNHKGDAQQPAELSHAHRLLPNGLLIADPSSPHPIYTLIEEANKNWEQKLGKASRSLSEAADEYRRRYERNPPRGFDRWWNCQMNMIRSQVNLDLEPFHALTPSQLRAHMDTVSRHSGMYTISCPGASNSKPSARCTFEIVEGGLNDEGKRVANQRARAQVELLEDVEELLEEVQVTFFSHDVPWQFVGHEYVSGLVFERPAANARHPDKKQLDTAHLGWASACAPHKPLRETYDPSILPDLADLWQNDKSFIWDHKASMDPCIHPELTHLVGFLSGHGKGPGPRKDIYPVLAMCKTTLHADVLAVSMEAWTEDVEPDPAWEHKDDRMIWRGKTTGIFFREGVPWNISQRINLVQHTGQKEGTLPVLPPALDSSSPVGYPVETPLGDLNDDLVDVAFVDHAIQCDDAVCDEIQENYHFGDRKTWAEGNGYKYLLDLDGNGWSARFKRLMTTQSVVLKSTIFPEWYTDRIQPWVHYVPLKASLTDLYDVLAFFRSSPSHDDLAKGIGQAGREWSLAYWRKEDMIAYQFRLFLEIARLMAPDRETASFHLRGDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2P6</accession>
    <name>A0A1E3K2P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034766.1">
        <property type="nucleotide sequence ID" value="XM_019173040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2P6"/>
    <dbReference type="GeneID" id="30190081"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="700" mass="77732" checksum="6FD9B78E067BF3A5" modified="2017-01-18" version="1">MPRTPSLSPLADRRLSAHEPYASAAADSRQPGEKKQPPSCDACRARKLKCSGRPQEIELGPDSIATVPCDHCREWNLDCSYLYQRKRRGRKNKVVEQLAEEQRARKQQATGNGLLAEQQGSSNHVGESLSREDGQRGRAFEAAPEASFGSSIAQDGLSHFRYQPFSSHPPPTAFDYRPPPLPAAHAEANLGRHYPQSSSRDIPRMDPPPSVRHDTRPYPPTFNLAPDGPQPAGPSPEDGVSPSIALSEASVPPTTTIESVLPRDLAMHCIHIYFDHVYCIIPVIHRPSFNADLAAHAEERNPVFFALIMAMIAATLIHVPKSFFPAHHHDSIRRLSVKCLKACYAVTIREMDNTSVDLICIKYLIFVVHNKHGNSGLEASTFGEAQYLAISLGLHREDTYANFDPITAERGRRIWFLIYNADKFEAVARHKPVLLRNDEFLGPESTLFPAEVDDSAITVQGIRPSSNPFPLICGFNILTRIVSILGEILLMERDMRRRQPSDPEELLAALKEVRKVQQQIKQVTDNLPKPFKLDVGQSSSILPEPGWEEAIRDELDLFFADPLSSETAKDGYLVLKGNIHVTLAMTRLRLILHREDLLIKSGQPGSSNRYAAELISTDVGEMSTDWRQSVYRDLFNTVHCLPIQALAANGPSVVTKIRVVAVTLLDALPAEEVNSSVQGIADYLLDFLNIMSSIEDQTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2W8</accession>
    <name>A0A1E3K2W8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035005.1">
        <property type="nucleotide sequence ID" value="XM_019173279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2W8"/>
    <dbReference type="GeneID" id="30190320"/>
    <dbReference type="OrthoDB" id="2564921at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="26566" checksum="081A51683C82459C" modified="2017-01-18" version="1">MLETTIGQLPARQIERPFQTQHDLRQRQERYNQSGTEDLESEYDFGDEDDMGELSDSYSSVHTTSRPVTPSHPPPTPVHITSSSSSSSSPKNDIFKLADKAEKILGLTPGTLPYARANLESAREQVRRTAAFPSPEPVPLSLSPPPTGEDAEPKSYFDMGGKSKKQSKMTRARKAMSVTGLGGLAPGKIASVVIGTGGKEEEERHERRRKATDGVLYWQREVARLVEEDATMNATLKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3C1</accession>
    <name>A0A1E3K3C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035008.1">
        <property type="nucleotide sequence ID" value="XM_019173282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3C1"/>
    <dbReference type="GeneID" id="30190323"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000035">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="271"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="44351" checksum="AB8174004378FA63" modified="2017-01-18" version="1">MASLSTRLLQRPPQLLSRSIHTSRALSAPKPSLVPPPTALSALASRLSLQPSPAVSTSLITCLTHPSYLAEQTEDANAEIDFSETSESNELLATVGNSLIGLFASEYLAALYPYLPTQALQSAVTAYVGPAACVSVGRELGVAVQGGGNAGLPGTGKGANSAGVVVRWSRTALAEKNWRDNKGKAMEGLKVPVGRRFQKFLKEQEQEAAAEAQGEARGKKQQSHEDVIASAVRSFVGLIYQEEGIHTARTFVHAHFLSRALDLASLINLNNPLHVLSSVVSSHLASAGVPSSSFETAIQPRLLASTGTNSQAPLFLVGLFLPSGLKISEGHGSSKAMAKHRAAVNGLQSIWFTRGDQPGAEVLGIKGLGKPFGEYGEGLPSSAHEDWVYEEGKVIIGEEESEFESIEWGGKEVLPGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K493</accession>
    <name>A0A1E3K493_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035120.1">
        <property type="nucleotide sequence ID" value="XM_019173394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K493"/>
    <dbReference type="GeneID" id="30190437"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="190" mass="21142" checksum="F5D89B0F3B2E60CD" modified="2017-01-18" version="1">MFSSAITPLPALRTSSHQIPAFVSFPNTSLVGHPLIIYHSAFSPASATATSVEKHLRKVGVVEPRWRYTMYRQHHYHSTTHEVLVVTNGGARLCFGGPPEKANEGRVEVRVRRGDVMIVPAGVSHALMEDEGGFEMVGSYPKEAESWDMCTGQEEERGEAWDTIRGLKWFEKDPIYGEEGPVLSSKDDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4J9</accession>
    <name>A0A1E3K4J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCR4-NOT transcription complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034914.1">
        <property type="nucleotide sequence ID" value="XM_019173188.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190229"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="320"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="502"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="696"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="12">
        <location>
            <begin position="1260"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1607"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1982" mass="221898" checksum="AC5CF8D40E80C411" modified="2017-01-18" version="1">MSIPPPGLGGGVTRTGPPPGFGGGGLVHPPPVPPVNDASVAGPPRSPGTIPLEDVLFELGEAMTQDDATVETLARRWWTPWLFEGTPDQVRKKVTEETCHVVHGLCEGVARGRAVDLHGVVKGLSAIDAISWPDVIKSFDTPMTIAAYPSSLPLLVSLICIPPQIPVPPMAGLLPANLDSPSWENISSLLSVLSHLTNLAPDAMPIFTMPSAPPSTLYARIVDPPATEQVWSKAARQQARDLQGAGLWNTLGLIQILVHACALAEADHHSEREREERAEIGRRATEILEKAAKLAPELVLIALEKQPKPLPSPVVVQQTRLLAMYLSTKPTDITSSALVFHQMWEINPDNLLSVLLEFYGEDENNLGRIVEIGSELKILGRLLAIEDNFHFVLDVAALASNRELLNLEQWLADGIEIKGEEFLQEIFDFVEHKIRLEFEHQHQPETAPPLLFTLGPTVYSIFIRVVRNAPNLAREDIGRFKNLRTDILILHPRLLNLRPSSKQEQGFAEAKFAKDVVDKVDEIYQRMYGGQLKLDEVVDELKSFQKSDDPKEQDIFAHALHSLFDEYKFVKSYPPKELTMTGLLFGAIIDYRLIKDTPAFVATRYVLDACKTPPHEPLYQFGINALSVLRNSLVDFPGLCRSLLEIPALHESHPVLINDIQQALVEREELDLQGGVKLAFPALKLPVLIEEGDDEFKEPETGKKDAIMFHVNQIAPTNYEDKAKSLLELFENQHSRWFAHYFIDVRVSLEQNRHEIYMQLLQKLDSPILDRHVLWETYRKARELLNSEATINSASERAVLKTMAMWLGRITLAQNKPVRLKELSVKDLLIQGYDTKRLIVAIPFVCNLLAACKDSVVFHPPNPWLNAILRLLSEFYHFGELRLNLKFEIEVLFSKLSVELSSFEPSNLLRMHVPPPPPQEEVPNRLDAELQRATSELMNGSQRLSDLPGNEAYARIQQMQSEQAVQAAQDALARRVDELIAQLPEYLIFNQEYPIFTAPTLKRIVHHSIDRAIREIITPVIERSVTIAGISSRDLIQKDFGTEPDAIKMRQAAHMMVQNLAGSLALVTCKEPLRSSMINNVKSMLEQNGYTDETMPDVMIAGVVNQNLDVACSVLKKAAMEKAAKDIDVNLAPQYAARKAHQNSRSTAPFWDGASFGVVISHTALPDPLKLRPGGLTAQQFRAYEDFGEPTRMISSQATNGDYLSSAYQNLALNDGLVSSDIKPAPSPRPVFPEAVDEVASPQAIPPQGSIDKFHELAAEIQKIIAQSNVQSVAALPADHELRALIRGIVIIANQSIHRENTTLAIAQKVVQLLYRSSLQLAREVYVFLLQQLCDLSAKVNKEVKQWLIYAEDVRKLNVPVTVTLLRAQSVSVQEQDLALSHIVLRSFPPEVIDFITELIRECSVSEQAFVPRQAFSHSLASLLKAREAGHSTAAADALLEELRGPREPQSADDDDKSKTVVDSKLQERLAHYFLEWVRVFSTGKSPEVAFVPYITYLQKEGILSGEDISSAFYRTAINTAVDFDGAKLATDVPPKFYGVDALAKLIILIVKNYGDKSGSTSVSRAVYYYNKIITIMSYSLVQRQLAMGEDFNQRPWTRFFTSMLSELSAFEYTLPETYLGCLKHLANNLGITQPTYAPRFAFGWLSIISHRLFMPKLLKTQRDEGWPEFHRCVMWLLRFLAPFLQSDEMTPSAKSIFKGTVRLLILLLHDFPEFLVEFYHTLTTVIPPHCTQMRNIVLAAFPPTEVPLPDPYRRLDQLVPEMQKFPTVRSDYIGALADGNVKAAIDQFVSSGVPPLPAIVAELKNRIAVKSLGPQGTSTITWNHTLMHASVFYLGTTAVTRKYQQTGIVEFDAKAPEVAMLAGLAHAFDAEGQYYMINVISDQLRYPSAHTLFFIHFILFLFGMSIHPENSSAIPERIARILLERTIAKRPHPWGLLVTFIELLDNEAYGFWNQPFVRAHDDVFRLFGTVRQNVAALRELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K519</accession>
    <name>A0A1E3K519_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035151.1">
        <property type="nucleotide sequence ID" value="XM_019172209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K519"/>
    <dbReference type="GeneID" id="30189232"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="133" mass="14804" checksum="3B62B7D95B597119" modified="2017-01-18" version="1">MALPKPTGLVMQIIIPKDLITVHNWPTGPLMAQSAHAATAVLHKFRDHPDVKRYLEGEDGRGWEVMRKVVLQVKDGDTLRQLAAKIDAMKNPIGYHLWTEQPENIPAALALVPNKRPKALKVALDEAGCELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5H6</accession>
    <name>A0A1E3K5H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035291.1">
        <property type="nucleotide sequence ID" value="XM_019172349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5H6"/>
    <dbReference type="GeneID" id="30189379"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="47279" checksum="137D2F54BC572D69" modified="2017-01-18" version="1">MESPSPRCPCCQLDQHPLYCASCLREGIALHNELLSNLQSRIDSIVSQSAGLLESGPYAAGPSREKGRGVSAWRELKAEVADRERRCAALRSKIAEKEIATEDARSRAAQSTVHQRRETLSKVKASSSPATYLQQSINNTRLGQQDATLRIIHARQVLVREAVAVFGLCTRPSGEWEIAGLVLPEPERFRLHSSYNTNAALLHTIHLLSLVTSYLAIDLPYLPLPPPPLEKPHIGRPLIKPNLPFVSTTKWRDKHVLWMSSTASIASKLKTRGEPPSSAKLLSNPTIAGIIAKSSSKQKQFLTSFALLAFSVAYLAWSQDVPGIGIKDADELSPTESDDETHSRPQSRAAPDRSAVLISATSILHLIHATALSPTLGHKSHAPGGTRQLGHLGFGLDVAKVVGTVLKAEEGKWGGRRGDDGEVLSEGWDMLDNGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5S3</accession>
    <name>A0A1E3K5S3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035357.1">
        <property type="nucleotide sequence ID" value="XM_019172415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5S3"/>
    <dbReference type="GeneID" id="30189445"/>
    <dbReference type="OrthoDB" id="10275300at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="42017" checksum="BDFF0052B6919F54" modified="2017-01-18" version="1">MPATPTSTTSLSILPPEIQALIFHSIPFCCSKPELASFIRVSRDTYSQHVRGLYECIELTRHNASPFFREFLSHEPVKEDWSIQRWPVACRPDRCDKPAVFHSGDSFMSKLHLFGYVKTLKAQEVEAIVHMRQAVRWLEVFDLNTYVEHVQEEKQERELLRLFPNTEKIAFGPSALWQLSEQQVFVAAPHCALYKAWRANKKHYCLHMPNKEDTALFHSSGIIRHELPNFMSSGDTCTVHNGDPSYFITPPGDTSRLSERGIEAKEIKMFVKPGEKANENRIDLQKTKMLAFFNSYLPTEIARSRGSTPQYESPKQFVFANVTGNKDEILDAAKRSCGSDPDRLDRLQSVKIFAKGDASVTPCVVCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K658</accession>
    <name>A0A1E3K658_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035407.1">
        <property type="nucleotide sequence ID" value="XM_019172465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K658"/>
    <dbReference type="GeneID" id="30189495"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="940" mass="101967" checksum="16B81C48AF6F7681" modified="2017-01-18" version="1">MPDSNPIPSTSPDTQQPGSMQPPALPLKKTSLPPGEGGGKKGGVKIVKGEKAGTGRQSFSCAECRRLKLKCSREWPCTSCEKRGCAQICPQGVMQTGKGKRLILADTAELHERISELELALSQAHAKTTDAPHPLLASPYLFSPRESPSRSRPSPSASGLRHGSLPGEDRLEGAVGTLTMGQEGQATYVGSFAGSEYLREEAVDEDEKSATEGPLRTPPATARTAPQTRPPQEREEDFWPSLGLHASLMAGGEVKWDLNSLRAELPDYEIEGRVLVAAYWENVNWQYQMIPRVMFENDHILNAYDTASPVNAHKLACVFLVMALGVMYDLHRPPFDPRGEQLFSLGRACISTVGIEHASPATVQALLLMGTYILNDKRGNGGEVFWPILGTAVKIAQGLGLHRDGSNYGGLSQYEIEERRQTWWEVVTYDRLQAICFARPCSTSFKWSDTKLPETPELIGDEAGFHRAKYQFMEFMERVIEIQTQVDPVSFVTVAQLDQEVREFKKNLPELLMPNVPIQDLPLDSQIHPHLVIHRFGIRLQIAQTRLLLNRPLFVRALQDSPTDPSHSAKLGESFVALFESAQEIVLLVKYLVIYHPSLIARWWFFWFHAFSAAVCLSAITIRAPYSAFANPSFHAMSMVCDISAAAREGCRAKRGLPILLRLRVRAHDALAAATAAAAHKSRSQTAKGHGSSGEDDDLSHLAGSGKLRRVQVPHQRRLSGGSGPQGNGLEGTPSPGSGGSIGTASTLVESGLYEGIIPPAPVETPLASRILPSSANSHQQRTTASGSGSSWHPGEPMGPFLTDMTPTPSFAARPQDPNFLAHQSSNWVPSSPPVDSSNFSGSGVSPEFDPSTEMDISAAFGMNSGMHMGMSLDNHSIHHYGAGEPLVRGIDIGMMGMNVPGSMQHGMDTGAVMEITHEGGAEAETLGFDFAAFVDNMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K684</accession>
    <name>A0A1E3K684_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle subunit SRP19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035445.1">
        <property type="nucleotide sequence ID" value="XM_019172503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K684"/>
    <dbReference type="GeneID" id="30189534"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="362" mass="39434" checksum="E36F5805BABC9072" modified="2017-01-18" version="1">MPTVEDYFDDDTDIPLPAASASKPRPLPHLGERGALLEEITDDDGDMDFERIAEQGRGVFGENSSAPPPRAPSGNGKGKMAQRDDDLRPSTSQSGPRIDPNTPMGGFMGDMMKLQADEEERLVKLRRQFGNAAVGGDPSLYKDWNSLYPIYFDAKASVNAGRRVPRSSAVWWPLATHIAQACSALGLPSILEPERCHPADWENPGRVKVQFEKDGRFVNPIVKNRTDLYRHLADQIRQRYPDLAFNPSTTPSRRHKAAAPAPATKAAPKKGKSKAKAAPKAKLPPPPPKLPARPPLPPTIPALDDRLPLHSPVVPAGVAVAAIKREKEQEKERKKNGQVEGAAPGEGKAPKVKKIMVRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6G2</accession>
    <name>A0A1E3K6G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'/3'-nucleotidase SurE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035629.1">
        <property type="nucleotide sequence ID" value="XM_019172687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6G2"/>
    <dbReference type="GeneID" id="30189720"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="46362" checksum="EB79ED3281FDFC6A" modified="2017-01-18" version="1">MAPLRTYTDRPVVLLTNDDGPPCASSPNIFSFCKLLQSKLGWDVRVVIPDCQKSWVGKAYAISDVIAASYFYPLEPDGLHGDITTERRPLKEGETMEWVLLSGTPATCANVALHNIYPGEIDLVVSGPNHGRNSSTAFALSSGTLGAALAASLSIPIPGPSSRPSLHETHIPSIAVSYGVVTRPVSPRLLELATETAVNVCQRLFNSWGEDDGPGGKGLVPIYSVNVPLVEANLEEGARKVCFTDMWRNAYGGLFKVTQLEPSLIWWPKESKPKPGPQTKLVSAAASTASLQTVQSDRKCQGQPQASGSDNHLRSKVSFDPGDHAASWDQRSTTNQPQNVEAPLHSKSSAAGPNALPTSTNSPKTSAADDKQLKFHFAPNMKPLLFPDEKDVPEGTDAWAFAKGWTSVTPMRAEYACVAHGNFQYGKLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6M0</accession>
    <name>A0A1E3K6M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035566.1">
        <property type="nucleotide sequence ID" value="XM_019172624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6M0"/>
    <dbReference type="GeneID" id="30189657"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7038" checksum="113E878F59037245" modified="2017-01-18" version="1">MPPRYKDKQPLKTLASASKSCATQSLAYGKCIGRSYTDVSKGMCETEFKAFKECVQKAVGRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K755</accession>
    <name>A0A1E3K755_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035825.1">
        <property type="nucleotide sequence ID" value="XM_019172883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K755"/>
    <dbReference type="GeneID" id="30189923"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130850" evidence="2">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="37762" checksum="C76265B89F369782" modified="2017-01-18" version="1">MRPFLTTLAVLAAATSIHALAREDYLSATENFIQQYLSPNNEKVAHSINSTLFAENVTGTVDILRTSSSLELTTSPPAFSFDGRELATEYLFGFFVGQAKDATDPSPYGIPVSYKYSALMIQEPYVQASVKFGFYYPVLNTTVPVQIDIWFLFNDNLEVQQYDLVLRRAAWAFEDLAPYLTPFMAARLSLPQNTSQPTILRSYFTQKICSTALSYCNGTNQQYSSFEDCEEQLGGKDLGEWFRAGDDNLVCRNLHVPMVPLRPQVHCEHVGPSGGDMCIPRNYSQVVLDEHFPAGFLAQQPHQVSGDASSSPSSPSPPTDDDEEDGDDDEEWKRQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH13</accession>
    <name>A0A1E3HH13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000055">
        <property type="protein sequence ID" value="ODN75629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027899.1">
        <property type="nucleotide sequence ID" value="XM_019180130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH13"/>
    <dbReference type="GeneID" id="30197370"/>
    <dbReference type="OrthoDB" id="2578283at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF251">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="382"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN75629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="536" mass="58455" checksum="7DE3AE5449372963" modified="2017-01-18" version="1">MIPTTSRNSPGSPLHEQTSYGVKRKYHDSPPPQPKRSRKTPDTHLPTPPNSSPSRPLSPQPDKPLLPLPLEILNSIIGLADSGTLRTIAGVSKTFRSESRRVRKRQLSAVTGGVKATNTSNSRADLRCPMDRQFGADEHIEFSVYDAECRISANPSEVMTTGKSEFGVMSSVLGEGRSKAPFKVEGQLGIYKLSWNGKSYWATRALNQEEDDAFGSQLLQLGFLGRLGALFKLFREEVKSEIVITVSYCFVIREDLPQALSPSGKAKVESDPLVRAAKVKEEEARRVALSKYATVKEALSVATGSANNDDEPREGARIMYTTFSEQTANDNPSLLAPPSWPLHPGPFILAPSSWPSPSWPFPPGRKLDRFLSGHLDGAVGALDGTHIVVNVDERDRPRYRNRLGRLTMNVLAACTFDMLFTHVFVGYEGYEGSANDQVVLSASLEKGFAIPEGRYYLADAGMGLTPGFSFPFTACEGGDKDSPFDQSKVPFVTAEILPTGNQRTFLALGRVAMLRGLANTFTPTLAPSLSPLPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HIX6</accession>
    <name>A0A1E3HIX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_08133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027914.1">
        <property type="nucleotide sequence ID" value="XM_019180104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HIX6"/>
    <dbReference type="GeneID" id="30197344"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14995" checksum="0CE10341D523F888" modified="2017-01-18" version="1">MVRSKFKDEHPFDKRKAEAERIRQKYQDRIPVICEKAEKSDIPTIDKKKYLVPADLTVGQFVYVIRKRIKLAPEKAIFIFVDDILPPTAALMSSIYDEHKDEDGFLYVLYASENTFGELEQYAVEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ19</accession>
    <name>A0A1E3HJ19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027935.1">
        <property type="nucleotide sequence ID" value="XM_019180081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ19"/>
    <dbReference type="GeneID" id="30197321"/>
    <dbReference type="OrthoDB" id="2581980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53562" checksum="1CE7505A9BB71E52" modified="2017-01-18" version="1">MSRPATGSSADLKTILIPCAPISTPHVPSGTTEIPLGDNSLTAYLTVSSVLAFDGALDESKLVKAISLLSGAWPTLAGRFKSVGEGADTKFSIELTSSPIPFETQTIERDQAFPDKLVIQPTIKPYMPPLNPNVRFPNTDNHLFSVRLTTLLPSNKSVLGVQVSHLGMDGTMARHLVKLLDALYTHGEAALQSTDSEIVIPTFFPGGVGPLHAYDASTDNLAFAVSWKAFPEAIRCYIADFKTSSRVALQFTKPELQALRDQYQLDSELKLSTQDAISAWWATLLNKVGVDVKSIVYFLDYRKWCIGHPSFPPNLPTLAAGVSQVSPIDISAASTPGQVAETIRKHISTLRASEKDEALHWLSNASRYMHESTVNDQAVVFGGDEQFQAVVFGGDEQFMADHKSVIVNSNIRIDWSFSFGFKKHQVSYHSEFTCSHFLRVYQANLDEGEEKGDKIELYFHVPKGQAEKAKEIIQSDREQWAVVSGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJC7</accession>
    <name>A0A1E3HJC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027972.1">
        <property type="nucleotide sequence ID" value="XM_019180025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJC7"/>
    <dbReference type="GeneID" id="30197263"/>
    <dbReference type="OrthoDB" id="10594482at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="19960" checksum="080261D9DF6EA352" modified="2017-01-18" version="1">MYKFYPNDPTRAAYRQSENDLLPAEKELVSDFWHPPPLGRSPPPKPSSPSGRQPLRAYFDIEIKWTKPQEAALVAANLAASTRTTWTLHPTSTARLQQGPKWNGRMLKGDLRGWWGLMGLVREGAQGEPQEQGQDSRPLASSPPANPMRAMTVRLDLVEAAGQGAGVCAIDLTGINSDKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HM04</accession>
    <name>A0A1E3HM04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027986.1">
        <property type="nucleotide sequence ID" value="XM_019180039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HM04"/>
    <dbReference type="GeneID" id="30197277"/>
    <dbReference type="OrthoDB" id="2575495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN76471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="534" mass="58265" checksum="4F21B33502FE7E0D" modified="2017-01-18" version="1">MRASPHSSTTPAQNSYTSEEGHGMYGRERSRAYSEHPTPRGGKGGGSRRQREREWDGDAAYYPDDDRRSRRRGDRDRGREREWQRDAWDQEREREGGRGGAGFDPDGPMSGVNAIRPRGSTGGGGNLSVGPLLRGVGLYLTTDLMDLRENRAVLLGTVKSMAGTAIADALHTRVQVVVVNIDPDWPTNLCLLVQADDTDTFDVCKEYNNWTTSNAIRHLAQVVGDLREGEVKWRKRVVRKEWLSACRDSGMYLGEKEGFGGWEVKATWDPHLASRPNEPYAGEDGEHQNDEYHPGERENVQGVDDLHADNNGNASPSRLPLDIPDRLLSMAQPRPPLDPSPTKPFDPRIKINGTEPYPSPQDSAYLPRATLPPAGSPINIRRPAPQLSEALSGLMAAPLPVLNGGLGNGHGPPSRAGTATGSAVGSVGSGTVGTRKEGLFVIGGMVPLTFFMVEPSRAVEIMIKTLGAGIITLPHVAQIHLFPIPRLTAPQNPDHVSALEALRGDEGKVAVSQEWVLDCCERMEVLPMEAYLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV09</accession>
    <name>A0A1E3HV09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028187.1">
        <property type="nucleotide sequence ID" value="XM_019179820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV09"/>
    <dbReference type="GeneID" id="30197049"/>
    <dbReference type="OrthoDB" id="2590631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="370" mass="41218" checksum="F2E7A0640855D0C7" modified="2017-01-18" version="1">MLSAPLHCSICAIPCLLPRNELPPPKASFLADSLVSPSKSSGVGATCWLNEWYCLRVSSGIVRPEPFLPPTPPISPTSKACPSPGQTGAKTKRCVPIHAYCLLAILSTIRQSQFNNAQTHEEKMMIEWSLPRWSGFGPWVRKGDEEGEGAGGGLSLGHWRGLVSQRERWEMEGKHYLDSDLLSPFDVGEPSSTDPLPYFRPLQTSILTTLPYTIIYSIFLSSLENPDLPDVSQLTSSPTKTLPKLLNPSAINDFLSLARTCSDLWHYPLSSNIWALLVLDDVRRWKVTTLSRWRANPSGVGSALHLSDALDASFVDPIIKSLGASREEGAEWKAKDVWSWWKFGNGWKSRRRVWYCVVHGCATARDADWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVF4</accession>
    <name>A0A1E3HVF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028214.1">
        <property type="nucleotide sequence ID" value="XM_019179792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVF4"/>
    <dbReference type="GeneID" id="30197020"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="474" mass="50415" checksum="537343888CACAFB0" modified="2017-01-18" version="1">MSSPLHIIVNPAAGAGNGPQFIDNHVAPLLDHLNVPFQIHTTEAPAHAGDLGLAILSAHQAAGTLEPIRVIVVGGDGTTHELIEGLQGNVINERKGSTRWELFILPFGTANALYSSLYPPGSPLPDTTFLTSLPTPISEDVIKHILPLIAYLSPQKDAKPFPLPITLTTLNPPASASAPPAKAIPTHVVLSTSLHAAILDTSEKLRASQPGTARFKVAAQESAGVFFNADATLFPVHAAGGVGNVEQWDPKTDSWVTPYTLGEPKGAGSEWTVSGPFAYFLSTASVDRLEPAFVISPKTSLRPSPPASSSTSATHAPTSLENQNQYIHLTILRPLRDPFVSSLPPPQRSATWSQRAFEVLAKAYHAGSHINLTYPVSAAGEVGSESWASEVKGEGEVVVELFRCGGFDWVPLFSQSSVVEDKRDEEEEGVDKDRARLVCADGALHWIPQGGKAEIRLSVPGSDSGRDGGFFIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1V0</accession>
    <name>A0A1E3I1V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_07755</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Prevacuolar compartment membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028290.1">
        <property type="nucleotide sequence ID" value="XM_019179743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196966"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000004">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000690">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000007">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129529" description="Vacuolar protein sorting/targeting protein 10" evidence="19">
        <location>
            <begin position="20"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1365"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="50"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="20">
        <location>
            <begin position="724"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1471" mass="163505" checksum="5BE24D69978892A9" modified="2017-01-18" version="1">MLLLPALLGVLISALAALAADPQVTVNRIENLPNRLFYFDDTPVVMYHDPAMLTVHRSEDEGKTWEQITGPIEGEAIRLVEHPHNNEMAFIIGRYTTHWVTYNRGATWQSFVTPRDASLGGKTLTFHSGHDDWILFQGVACESGGFGKWGGKTCWDETFYTTDAFRSEPQLLLSQTSQCIFARSSEAFVSAPEKLVFCVAFDQSQKPGSGGMHSIKESRLYSSEDWFENKKFVDLGIGKRARGVVGLGVVSKFMVVALNVADMGTKRAGGGDPMALYVSTDGLEWRQTQFPHSALPDLKENAYTIVESTTHSIAVDILTSPSANIGTLFVSSGEGTYFVEALADTNRNEYGIVDFEGLVGLEGVGIANVVANREEVVGWGEPKKIKSKITYDDGSSWKFLSPPAKNLNGDDWSCDTSDLSKCSLHVHSVSTPHNIGRVFSSTAPGYVMAVGSVGESLLSYDDCDTFLSTDAGLSWRQVQEGAHKYEFGDQGSVLVIVDDEQATDHVHYSYDGGHTWTQLDLGVTVRGLVLTTIPDSTSQKFILLGTLPRKDSGGGRHAMIQLDFAPLQTRQCTDDDFERWYARSGEGNECLMGHKQWYQRRKLDAPCYVGHKFEDPVGHEENCACADEDYECDFNYVRQDGECVAVGPEPVPPGTCNKPDGKYLGSSGYRRIPGNTCENRSGQAKDSPINKDCSDARPESGSPSHVVHEFESDIISHSYFPLSQTILIQLADSTVWQSSNEGFSWKQLYEDETFLAVIVHQYSPERAYLLTNTRKIYYTTDTGRSWNTMNVPNDPNTLGIPIIDFHPTKPDWIIFTGSIDCDDALSTSCRAIAHYSTEHGRRWRKIDEYVRICAWARDQRLKIDEREIICESYKNKKGSQISGDYNPMELIAGGSYYSKKNKVFDSVVGFASFSEYLLVAKLNEDQGTLSLQVSLDGYHFSEGQFPPNMKIENRAYTILESSTDAVFLHVTMHSGQNKEWGSIFKSNSNGTYYGLSLDYVNRNTAGYVDFEKMIGLDGIAVVNVVSNPSEADISGRKSIQSRITHNDGGSWKPLNPPAKDSLGQEYWCQSTSCSLQIHGYTERRDPKATYSSPSAVGLMLAVGNVGEELATYTDSDIFLTRDGGYSWEEVHKDAHMWEFGDSGSIVVLVNDEEATDHVLYTLDEGLTWQEYAFGSPLRVKTIQTVPDDTSRRFFLIGSSPSNPSSSYLVHLDFSVITQTKCELSIEDPNHDDFELWSPSESREDQCLFGRQTMYHRRIRDKNCYVGERVVQPNTIVRNCTCTASDFECEFNYRRDASGNCVLVDGAVALSSNTEYEQCDGYTDYWYERTEYRKIPYSSCEGGERPDQGRRHSCPGLIVGGVRRGALFWGSIAILPFAIAGLAGYHYYKKGDQLGSIRLGDHRAFGGSGGSSDGWVAVAASVPLFLVGVAQEGWAWVVGKVPFLDDLVTRRSNYRSVPIDEDAEVLGNYEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5I7</accession>
    <name>A0A1E3I5I7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028340.1">
        <property type="nucleotide sequence ID" value="XM_019179652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5I7"/>
    <dbReference type="GeneID" id="30196875"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="217" mass="24229" checksum="0573786F74794D60" modified="2017-01-18" version="1">MLENLAPLLQQSESIDRENIFKVVGHHEGRIQTETPTMLYFQVLDGVYHATAKDLNLKDDDSHAAAFGASVPKWPAFEDSAHALERLSRLGLRLVILSNVDNTSFEGSKQKLEKGFSFDALYTAEKIGSYKPSLNNFDYALQHVKEDFGFSPEDILIVANSKLHDIQPGHEKGLKAAWIDRQKAVMGVSAFKDVIPDFQFPSMDAFADAMEKDKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5Q2</accession>
    <name>A0A1E3I5Q2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028394.1">
        <property type="nucleotide sequence ID" value="XM_019179626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5Q2"/>
    <dbReference type="GeneID" id="30196847"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129601" description="GP-PDE domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="32"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="42052" checksum="1FC6BF12361C4C13" modified="2017-01-18" version="1">MVSALLSATTLIAVSVPALAAPFRRWEYSKYWDLQGHRGGRGETVENTLPSFSWGLINGVTSLELDCGVTKDGEVVVWHDENFVDTKCRDTSPAFEDDPDYPYVGKYIANLTLGQIKTLDCGSLRQADFPLQDVYAGTKVSTLQEMFDFVKCATDEPVLFNIESKVDGDYHNLTRGPEDFVDAMGTIFYAQGEDVVDRITHQSFDWRSIKLSKEKYPNLRTSALCDDTTTNLGNPGSGPSNWLAGIDIDKLEGDTVGERVARAAAFINADFLSPVATSYASDVTGPGFPGFVAFTNKTMVDTAHSLGLGVKPWTPDVKNLFEYLLDLGVEGVITDFPHEFRRLLEQKGNYALAPKGNTDRILSCLSKHVQVTENRLDGKGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9V7</accession>
    <name>A0A1E3I9V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein EncT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028450.1">
        <property type="nucleotide sequence ID" value="XM_019179593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9V7"/>
    <dbReference type="GeneID" id="30196813"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="59737" checksum="9A1F519B431D896A" modified="2017-01-18" version="1">MSSKESPQLLESPIPSFEEPSRHRRQESSPTSSSTESGPISLHPLAQLSPLKKSVLLSIFALADFIDVGNVSGVAVAVSDITKDIGIQSSQGVWIITSYSICFSAFLLFSGRLADLFPAGIVFEGGFALLGILSLATSFVTGNKYGFLILRGLAGVAGSLSIPSAYHLVIHMYPEPKQQASKLALLGLAAGLGNVFGLVLAGLCMEASYKWFFRLIAILCLASTAIALWLLPFSLSSTYSTEAREEGQKKVPRWRLMDVPGVLLMMGFLICFILSLTQGPIDGWGAVSFIVPFVICWPCVVGFFVWEARISPKTAILPSSVWKITNSVVASLAVLIPMGFWGTSQLLYANYWQDAFHWKPLHVAVCMLPQGVVTLIVGGVVQFFPSMIDKPRRFIPIGSVLIVIAEVLQIKSTGGPGTDYWRFVFPAFVLGSAGGMMVIFASQINLVQMCPPEMAGVAGAWVSVLFQVGGALTMAVMSGLESSHPTFFMEAGGKVYYFIIGYTILLAGIYLAFYRTPKPLGEEHEAARKRIMNDVGKMGVGGVNSQRISEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAK4</accession>
    <name>A0A1E3IAK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028534.1">
        <property type="nucleotide sequence ID" value="XM_019179496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAK4"/>
    <dbReference type="GeneID" id="30196713"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="316" mass="34950" checksum="D6876263BD6AA6EB" modified="2017-01-18" version="1">MLLPCSPRCIARARLQHAHLFHRSASSAALPSDSSATSASSNKGKGRQSTLSQQYRFPETGKMGGPPNPYEVMALDPNASQQDVKQQYYKLALLLHPDSSHPSSSPDHFATLNKAYNLLSKPSSRSAYSKTGYGWDLASSSSSPGPSSVDQWMRAEIHRRRTYGAAAWNPASRNYRNSDEGKGAWGGFDGSKGWKPYESKTGFEPPRADTGAAEERYMSNPRFLAVVGLTSVVVAYMNWSHVGGSSEAHREMLDRQHFDASHALATARYEASTHGHIRRERIRRRVRQAEVMKELELAEQGHLALAEQGQFDSVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAN5</accession>
    <name>A0A1E3IAN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar pre-ribosomal-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028523.1">
        <property type="nucleotide sequence ID" value="XM_019179485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196702"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="696"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN85662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1931" mass="212206" checksum="25E81A8F199F0266" modified="2017-01-18" version="1">MSGVKRKRADLQEAGIPPIIRPKPGTKAFASGKAVKDGLDTGSPQAFVSFRQQIVTPHSTLPLAITHPTVIILQHYLDVSPTCDEIFRAWQIGDQTKSEQQVHAAVELLSEIIQILTPIPFFRSSVLGLVNKIISQSDPYHDYINHLILSAKKDDAYHGLLLASAAMAVDPPTVLPSSSSSSGRIGMKLWSTLVEGGSVRNLGKQMGMRRRNKDGMVAYGEKDPLDKPDIRHLILRLISPLFSTSPFQPHARSLLPPLYSNLASDPPITIFRVLSSLWAAITSQSGGFNRRVSLILFQERSIEALWNLLGNENVEKTSGKTVGELVYSFLIGITATPGKGVCFVDEGWYPRRAEGDKKDDERKESSNDAWRKGLHNRILGNVVRKVGTQVVDEDGIVGDWMIGVFEACPELVSGYWPHSALALDPRLNPRWTATMAYVGRLISLPSPPLQTFRVPAPAGTDPSLSPFRPEPPQISTVIESIVPSPLTRAHLMKGLQHTEGVVQYTTAVTLSRALSKLSQVLQLFSTIETELFGAHPSPANAWARGKRELEMEARKRIPELSVIIAFAQKSATMAPAEPETDEELALATKSTMLTESALRIFSLCNRALPSMSSELKFDVGRLLVSSSSTKQEKRDAREAREGSVISDSGSIKSAGTVGTAGMGGGFGTGRGDVRGFEALSQVHVLELLGEVRDWNWTNKAAGSQFTYLYHILLLHLSTPQPVTLSKTTSLLSHLLLPTLLFEHDPSELSIWLSAMPRGSRENYGPMLLVQQIHLLSFLDDCFRRCLKTPYRYIEEASKLIETSGWQSGNREMVSPLVMAILEQLSAKIMGQLIATEAACIVFNYLRRVILGLAGKQGNLSFLDRVVARLDEIVEKAREAGQGRIGLAEVVQVIRRNVDVTRGKKGSEVPGDVPRLMDEPAWASKSFETQSLETFSSETLLPLIATSDNASAQRHATFLLHLNVFRSSKGNVPAALEVFVKLFEKVGGKEEVDMKKAVFGDKALRKLVLSDKGDEYRAAINALTEHLKLGKSTDEEIAQSFVEECLGMLKDDKKGKKAPEILSLLRPWTTFLSPSQATQATETVFAFKKPLAPSPSITPILSDIITGTQSPTFAIKHLHELGKLGVVSAVERLLKGAEKSKTGYAELLGLGISSETVKYLMSESTDETLSLLAELVKTVPSAAQAVQPVLSGELKDERLLLVVEALLDLDLQVEGVETIAQLALQSLAAKTKSLAGSATQVLVLLSSTNSNEINNAIGQVELSSYTPAIASLTKQLAIELASTAELKPAVSHLIGLGLQYAVRVCSELGEIPAGTLTALVDIADAVSATDRDYFTIQQALVEPVITAVVQDRLDVDEAANLAVVLAGHVELKASFIRQQLQALYSTKAYTRSTTTSCPPTLRLNFVRLLHTLFAASTYTSCQPPFVEPLVLLYRGTMSEADRRILHMLQLFEGYRKISVASVMRFWSASGVLGIGGKSLDALTSLDPQKVFATCQAYPLRRTLRNWGKKSSNAEDGEDIYDPVFVTALFVASMSEKMHGLDWVEVLRGNAIGLVTCGLASRDKDVRSVSSFTLAKVMSLIEITPFLERTQLIYTMRLLRHALPSQTSRLPTLTTLFFAYAIRAIANPAHFLYPITTRFLLQRSVFDIEDTPMLYGMLYASGEFWKRERGWMIRFLKEGIRSEADWRVIRRRKVWTLLATMFAESLDPGFRRGVLQTMSNIALIPAATSSLVLRDGLLVWINMQWTTVTSHFASLPASSKSGAKGQRAQAWEKEEKKLLVQMAEAAIKVMSSAEKQRLKEDGKGVRGWILQAEELVKNIIKGKSTFNADFERLESLSSIASEIAQIPSNGVTTRLFHLLVKRLESLDGPSAAIHVITANLFEIGLTFSVPDLKDDGSLREALSSVSWRVERGDGGSQLRDWVRRERRLEELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBS8</accession>
    <name>A0A1E3IBS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028590.1">
        <property type="nucleotide sequence ID" value="XM_019179449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBS8"/>
    <dbReference type="GeneID" id="30196661"/>
    <dbReference type="OrthoDB" id="2578011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="38297" checksum="74DE52A2A3219F08" modified="2017-01-18" version="1">MAFSNSTSPSLGGLGSLPEDDVISLGSSDSSSSSASAETADPATPNLSPFEEADSGEKSVNKSVFPPAADQYGSSNDEEAAQDSETRSTRTDEMVDEAKLVEAFEEIGNFLERLESDWWASAKKEMNTSVKELLEQQSKRFEEAYNKVVQQETDIHRENTNGLITRVSQLEATLASLSNPQKQEVGRNQESTDGLVNRVAQLETTLANLTLQKTPPDIHVDVHMPSQQSTSTTADDAPPRRPPHDEDSSDGRPQSSLSLKDSLDWTAGLLMQMSYHYSSNGNIMRTFREARSMRQTNPSGCREKICELCGILEAFAARRRYPENRNPRDAWEEAVAMRAVELLKMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICB1</accession>
    <name>A0A1E3ICB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_07368</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028618.1">
        <property type="nucleotide sequence ID" value="XM_019179370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICB1"/>
    <dbReference type="GeneID" id="30196579"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="80"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="304"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN86075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="453" mass="51148" checksum="96FEC4A24E44F966" modified="2017-01-18" version="1">MSRPDEEELVDYDEAAEEAVIAPAPTAAATNGDKTDADKKGSYVGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQAILGTDVLCQAKSGMGKTAVFVLAALQQMQVYSLFFSFFFASTPSNTRVSEPVDGEVSIVILCHTRELAYQIKNEFTRFSKFMTNVRTGVFYGGTPISADQELLADKEKCPHIVVGTPGRTMALVREKKMNAGKVKHFVLDECDKMLEQLDMRRDVQEIFRATPHHKQVMMFSATLSKDIRTTCKKFMQSPLEIYVDDETKLTLHGLQQFYLQLEEREKNRKLNDLLDNLEFNQVCIFVKSVQRATQLDRLLQECNFPSICIHSGLQQAERISRFQQFKAFEKRILVATDIFGRGIDVERVNVVINYDAPLDADSYLHRVGRAGRFGTKGLAISFVSTEPDQEVLKKIQERFTVAIPTLPETVDPATYMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICD7</accession>
    <name>A0A1E3ICD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028648.1">
        <property type="nucleotide sequence ID" value="XM_019179400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICD7"/>
    <dbReference type="GeneID" id="30196609"/>
    <dbReference type="OrthoDB" id="10607584at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="47294" checksum="3F6892EBA4C738F0" modified="2017-01-18" version="1">MLFGDALSLLARCSDNDRTDPEDGLTCPKRWSIHKEEKCSSQRLDINSAPGTLLQAAIAPGNQRKAPVIPKPGPALLYTRPPGTFQPSLPQQQQHAQQQPPPQPQPPQPQPPQAQQPQAHARWQGVDLPLQKTVLFTMFVSAVCLAAGYWHNFDHPTVAGGRLYNYAGPAFWLSAALFLLPGFIAGWNRVANAEVQSRVWIGVAVVALLSQLYNMSSSQTPPQSQEHQPHTHSQCYVSERNLPGCWVVADLEGPQSQEQHQLHTYPPLPHESSQHSPSSPSPSPSSPSPSPSSPSPSPSSSSPSESPQVQQLQQQLEQQEHQQEQQEQPQAHAGWQRTDLGLQLAACAPFAFSLHAIFLGAGLVLTWKGRTVPGRRLKDYVGPSFWILGALLSFPRLIVPGTESTALGWLAVAMAALVLGIVSTVGNMVFASQGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDB3</accession>
    <name>A0A1E3IDB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Solute carrier family 25 (Mitochondrial phosphate transporter), member 23/24/25/41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07243</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028732.1">
        <property type="nucleotide sequence ID" value="XM_019179251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDB3"/>
    <dbReference type="GeneID" id="30196454"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="341"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="459"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="556"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="648" mass="71449" checksum="15EE9C70FD8E1DE5" modified="2017-01-18" version="1">MTNAPPHYTLGPHPPHTDPDITPSPSDPDPPPLPMSLREPPGPDIPSPTRSSTLSAFRASEGPTARAAKLRSLWNSLPSLPSLPDGDEPTDTKKMQLPGQGTTEALSLERAERLKRLYEEELVKTVAKKRPESALWGGPDDLEPEVRHLKGKKGTGVAWGDFRRFLWDKERELWDIFQDLDKNGDGRLDSLEIREALSRSGIDVTPATVSELVHYLASHASEQGAPKIGNKEKGRTGVYLTFGDFRDFLIMLPRKATPFEIYKFYQVRKRFSDGRGAARVDKEGDINISFPKAPNASSTSTAAGFFHPPKSHGLEDDEFADTPSEPLPEDELVGEAHEDRHEAWRFLLAGGVAGAVSRSVTAPFDRLKVYLITTDDFSSFNRKPGIGHPFKNGFRAMTNLWGAMKKIYVDGNGIRAFWVGNGLNVTKIFPESAIKFVSYEQSKKFLAKYWDCVSDPSELSSSSRFISGGVGGITSQLSIYGLETLKTRIQSDIGPNEGWRQVKRTAGEMWKAGGVRTYYRGLTLGLIGVFPYSAIDMGTYETLKTAYCTSAQTDDPPVFAVLTFGALSGSIGAASVYPINLLRTRLQASGSSGHPHRYDGFMDVYRQTMRNEGWRGLYKGLLPSILKVGPAVGVSWIVYEEAKRQLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEF1</accession>
    <name>A0A1E3IEF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028683.1">
        <property type="nucleotide sequence ID" value="XM_019179327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEF1"/>
    <dbReference type="GeneID" id="30196535"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15572" checksum="2209C24267E8D954" modified="2017-01-18" version="1">MERKQKVVVERHAHVAQRQSPNVATNTPCGSIVFHRCILRIGGRAARRGPKGVERLGAGEILLNSVDRDGSGAGFDLDLVKLVKCAVGIPVVSASGAGGPGDFEEVFRETGTEAALAAGIFHRKEVGIDEVNSFLEGSKMAVRNVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGG8</accession>
    <name>A0A1E3IGG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Syntaxin 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029032.1">
        <property type="nucleotide sequence ID" value="XM_019178938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGG8"/>
    <dbReference type="GeneID" id="30196124"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="372"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN87689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="49243" checksum="A6C4B9F76A52CABC" modified="2017-01-18" version="1">MSNPYLPLSPSNSAAPTTPYSITPGPYATASSSQEPTTRSRTLFYLSVRDSNPFSETSGRNASKRAERQYGQHISLDDGEEEEGLIGGREGHTEVGMKGLPPKWVDISEEVEEILARAKLKIAALDKLHAKHVLPGFTDRSAEEREIERQTVDITKDFRRCTSLTGSVRPSQGAPRVQVLTAKNVQRGLAQKVQELSGQFRKKQRVYMQKLQGHAIKNKDLMVASGAITLKGSDVLDELQEDEQAVGACVVHGPWLIRIQSQSQLQSQSKSQAAISIDIDQRSSEISQIASSISELAELFRDLGNMVVEQGTILDSVEYNVLQANQQITEGLGELKVAQKYQARTGRRKCIFFLILCIFALILILIYKPHSDSSSTPSPTASASGSRGMTFPSPSSGTVDAGDGYTEGEGDDEMEGIVLPSGVERVSRGAASPTLARRSRDRAKRPIEQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGJ5</accession>
    <name>A0A1E3IGJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029067.1">
        <property type="nucleotide sequence ID" value="XM_019178973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGJ5"/>
    <dbReference type="GeneID" id="30196165"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129747" evidence="1">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="14"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="39665" checksum="49B0FD6687BC3897" modified="2017-01-18" version="1">MLPLIALGALLASLHVQATSYPRVDSFSGQSFFDGFTYPAETYDNTTNGDVFWATASNTSLIYLNDDNHIILKVDNTSSVPYNSKRYAPKLLSKSAYDIGTVWVLDAVHMPYGCGVWPGFWTQGSDWPNGGEIDISEGVNKRTNNMVALHTGNGCTVTGGSSMSGSVTFDNCDNSLNGGSGCTINDTDSKSYGEGFEAAGGGVYIAEWATDGIRVWFKTRSDVPSSLTVSADSIDTSSLGRPVAEYSSDSCDIETLFGSQTLTIDITLCGDFAGAPSELALTCPALSGDATCYSTYVINDQSANFAAAYYEITYINVFSSSWSAGQSGGKVTGTVTATAGVGTGTGSSGENTSSRGEEGRAAAGGLMGLAGMLLAFGAAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIK5</accession>
    <name>A0A1E3IIK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_06701</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029239.1">
        <property type="nucleotide sequence ID" value="XM_019178756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIK5"/>
    <dbReference type="GeneID" id="30195913"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="401"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="679"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="954" mass="105148" checksum="92F518D319AB52E0" modified="2017-01-18" version="1">MPNRRIDGCERRLIDAPDVALLFAPPLRCHRRAVPIHPSSPSLSPPHSPSAAPLPTPNGLLKARKKNTAEISGLKMQDQGTRLTRLILQRKLLARSDRVKSVDFHPTEPHVICGLYNGQVKIWDYESGTDVKTFEVTDVPVRCVKYIARKNWFVSGSDDFQLRVYNISTGEKITSFEAHPDYIRCLTVHPTLPLVLTGSDDMTIKCWDWDKGWRCVQIFEGHTHYIMALAINPKDPQTFASACLDHTVKVWSLGNPVPNFSLEAHEKGVNYVDYYHGGDRPYIVTTGDDRLVKIWDYHSKSCVQTLESHSANVSFAIFHPSLPIIISGSEDGTIKIWHSSTYRLENTLSYGLERAWCVAYRKSGNEVAVGFDEGAVVLKLGRDEPAVSMDTSGKVVYARNTEILTANLSALSPSEIPEDGSRLPLSLRDLGTTEVYPTSLQHSPNGRFVTVCGDGEYIIYTSLAWRNKAYGSGTSFAWAGDSNTYAVQEGKSKIKVFRSFKERPNFLHSAGNYAIEGIHGGTLLSARGDGFVMFWDWETGQVVRRIEVDATAVSWSTSGERVVITAEEGFYVLAFDRDAYEARIASGEDVGDEGVEEAFDVIAEISETVKTSKWVGDCFIYTNSTNRLNYLVGEQPHTINHFDKPVYLLGYLPAHNRIYVADKSLAVFSYSLSVAVVEYQTAILREDYEAAEALLESVPQEQKNRLARFLESQDQKELALNLTSDPDHKFDLAIALSDLQTALSIVRAQEDSATSVSKWKVVGDQALKSWEMDLAKEAFERAGDLPALLLLYTSISDRAGLESLAQRAEAKGLSNLAFSAYLSIGNTSKCIAILGKTGRWAEAALFARSYAPTEMDGAVKSWKEELEKDGRGKVVEKIAEPGVDGELFSVPEPEPEPVAAVEEAAGSAGETVKENVEGLVEKVKELAVGDGAIEEPGSTPANGAAPKPKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJL9</accession>
    <name>A0A1E3IJL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029362.1">
        <property type="nucleotide sequence ID" value="XM_019178661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJL9"/>
    <dbReference type="GeneID" id="30195818"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="493" mass="52033" checksum="891E47203D1ACE7B" modified="2017-01-18" version="1">MPSFTRRIPQANPPPPGTTPSPIHSLPLLPTGLPSLDDLLGGGLPLHSILLVLAPDTQSAWGRLVERYWIAQSLTSGQSAVVVGEKQEAESVVQGCMWVEGGVDGDGSESEGEGGLEGGDKKIAWRYENMAKFQTTVKGNGSNLSLMTQVPPQALEAMKKSKQLSYVPVDVLDVPTTSSGQSDKSALLDNALKGVWEQLESAQKGRATRITIHELGSLDWGDISIPEIHRFIHSLKELLKMKPASALVTLPASFLVALGEAREGLVKSLSWGVDACVELKGFADDPTLPPLFPTHGLLTLHSYPTSHTLLPSTLKHSTLLGVSQSASSSSSGGGGGAGENNLGFRLKRKRFVVETVHLGVEGGVGERRTGGDVGDALEGADARTSHTTGLVGGVEPAAPAPAPAPEPVPEAIPIDERPKGADQDKPKKASKPRARVRFGGEEEVITVGKAGDGARAGHGHQHDHGSHSHAGHDHSHQAPKVALRHDRPDLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK52</accession>
    <name>A0A1E3IK52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029149.1">
        <property type="nucleotide sequence ID" value="XM_019178872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK52"/>
    <dbReference type="GeneID" id="30196050"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="448" mass="49972" checksum="6BD2A44923BA70B1" modified="2017-01-18" version="1">MGREIISLQAGQAGNQIGAQFWQKLCAEHGISPQGELEDWAAEGTQGDRKDVFFYQADDEHYIPRAILIDLEPRVINSVLTSPFKGLYNPENIYVSKDGGGAGNNWAQGYSAGERVYDDLMEMIDREADGSDSLEGFMLLHSIAGGTGSGLGSYLLERLNDRFPKKLIQTYSVFPESSDVVVQPYNSLLATKRLVNNADSVVVLDNAALTKIAADRLHIQDPSFTQTNQLCSTVMAASTTTLRYPSYMNNDLVGIIASLIPTPRCHFLMTSYTPFTSDEIDNAKSIRKTTTLDVMRRLLQPKNRMVSTTSTKSSAYISCLNIISGDVDPTDVHKSLLRIRERQLANFIPWGPASIQVALTRKRGMGAGSNRVSGVMIANHTSMGSLFKRMIHQYDMLRKRNAFLEQYKKEDMFSDGLDEFDDARRVVQEMQEEYQAAEREDYISHGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKQ1</accession>
    <name>A0A1E3IKQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029464.1">
        <property type="nucleotide sequence ID" value="XM_019178557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKQ1"/>
    <dbReference type="GeneID" id="30195714"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="479"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="710" mass="74512" checksum="4020D10F661ECDE3" modified="2017-01-18" version="1">MAPRQPVAGPSKTKHSQQAVTSSPPPPASVSAFNTARSLFALASPVLGQADKVQVWDVASDRVISEWEIPGASKASTVSFALIDAADTGGKKKKRRKSAAGTSEEEVLLVSTGKNQLVVLSPRQGEVLRTIDLEEGVTSAWTDERGFVFATASSLLVLAKDASAVSHTFSLPSNVTSPSAVTILPSSTAETLHVLVASTSVVALHLELASSEVTYTSSPLPASTTSVSSLLPIPSTEEGASFLVVSEDDRTISQYTLTTPQATAKLSYRYASPTLSSAHSLALESSLLAVLHESGEVSLFSLPSTLDLSRPKTDSKPSIVKVVEGKEEHTARLARVAFASQGQGESGALLCGRLVGGGSVKWSKAVYELPEGGLRSNTVLKVGVQDLATGTSGSSTLPTQRYVAPAAVTEAAEDTGDEPASQLPADVDMAELSLGERMLATGQGEAAKSTTATAGASLDGPVNAASLTRVLVQALHTSDPALLTLCLSHRNPVLIRNTIRKMPAQLALPLLKACVERLGQGKGANKRGGGRGSVQNEQQGRGTVEWVKGVLVERGSVLMTMPSLPQHLAQLSTLLQTRLELHQPLQTLSGRLDLALAQITMRRIAAEQALAHAEDGGRKGGEGEVYVEGESDDEDVEIEVGEDGEVEDVDMRGYSDASSDESGSDDEDDDDDDEEDSDEDPLESGSDNDLLDLEAEESGSDEEDDSEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKR6</accession>
    <name>A0A1E3IKR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029478.1">
        <property type="nucleotide sequence ID" value="XM_019178571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKR6"/>
    <dbReference type="GeneID" id="30195728"/>
    <dbReference type="OrthoDB" id="10333139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="108" mass="12704" checksum="3F896553B0C23796" modified="2017-01-18" version="1">MFVIKWDEPILVRAAHSPTRRAIEFRASRKTQKTVTSIAARRQLERIIPLLAEHMMDPTSEPLPARFDVFNERDRVIYQFKVICQTRRRDDINQTRPARVVVTAVECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM75</accession>
    <name>A0A1E3IM75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029527.1">
        <property type="nucleotide sequence ID" value="XM_019178371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM75"/>
    <dbReference type="GeneID" id="30195517"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017422">
        <property type="entry name" value="WDR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038169">
        <property type="entry name" value="WD_repeat_p55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="362" mass="40326" checksum="1C3924ED52648D29" modified="2017-01-18" version="1">MPDITLKNQPFDVEFHPTEPVLFASLLTGQVQSWRYDDQTGETSAGWNVRPSKRTARALAIEEGGDNIWMGGKGGGLYQIDTKDGQMTKERAGAHEVPVNRVHCVNPNLIASGDDDGVIKFWDPRQEDAIRSYSQHFDYITDFTYFDDKRQLVTTSGDGHLSVIDIRSNKSAPLSLSENQDDELLSIVPIKNGQKAVVGSGTGVLSIWNRKQGWGDCVDRIPGHPASVDAMVAITPDIIATGSEDGMIRVIQILPHKFLGVVATHEEYPIERIKLDRNNKWLASVSHDECLKLTDMEDLFEESDDEDEEMEEGDGDKSEEEGADSDSDMEVEKSKKAKKDNGMRDMGRKQMEEEDGSFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM82</accession>
    <name>A0A1E3IM82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06315</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029537.1">
        <property type="nucleotide sequence ID" value="XM_019178381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM82"/>
    <dbReference type="GeneID" id="30195527"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="825"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="196"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="572"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN89628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="896" mass="97566" checksum="CCB5B6AC7BD666FC" modified="2017-01-18" version="1">MCSSAPASSGRTSSPLRGCMFPGVISHPTDPPHLSEASGGHNPLADGHRESIASVGSSMSFAGDHGSGMEIDDQSTSPAELDSHARSHVHQPRPSPYAQPADCHDPSYLGHPTIAHQRESSSAVPIRPPVHPSTNLPRDTFSRNNFPSYTSLHQDRPLLASRPSHLEDSVRAHIPCPVSSTLGVASPNALERRIDSIESRLDRSRQRDNRGRLSPGSRPRPYTAFPYEVPSHWTNSSGTQRPSPHRSHARDIARGEASHHSSPEIAPAPALRRYRHAPEERDTRSIPVNDDATVPSPRPSPYSSSFSASFGVIGEPPNPSLLGLRHRPVSRGMLDENGSSSASPTENAFSDPLASLRASPDQSAAGRFRMNHDLPLPSPVNPYTSGRHNTLPPPGNPFGVWDSNISLALIRHEAERTTERDRILADIRERDRERGPIVSALDIETAEEIARRRVMERGRPEVAGPSQVENSDRQRIIESIRARQRMRDQYPTRARHSNLETAAVGGPVAGPSGSSSLYNDSEGDRETGQRERDGRFGAHGQHQAMVLGSDGREMLNRDVNDFVDRRLGVHRAPLPSPGLTSNSHAVGSGSSSLGQGPSNGQISSGAHPVHGTSGPSSRPLWGEVVEEGSVQRPPRRPPVLDLRNTPPVSFTPGFGGPSDMHNTEEDMADFGDDDDFLLPPISPWGQDGTPASTIAALQDSSRRRVPTEVIAALLARRPAQGGASNMLVDQGDDDLRSIMEHLVQPGDGGMSQFVSLAGLGSASISGKKLEPGMGEEEVKDTVECVVKYVKRSRDEKRRKWVGEMLEDIPWGHFGKREGMERDEYCSVCHDDYEPTTEISITPCKHMYHKSCLATWLDNPKTSTCPMCRRDLAVLSVLSSMVPDGKVETALPYWHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMF8</accession>
    <name>A0A1E3IMF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029514.1">
        <property type="nucleotide sequence ID" value="XM_019178358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMF8"/>
    <dbReference type="GeneID" id="30195504"/>
    <dbReference type="OrthoDB" id="2578280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="32776" checksum="E909DB134CF461B4" modified="2017-01-18" version="1">MPPKEIKPEEPAPGASKPFKALSVFFDEDGKPLNSDEASGRPILRIAKEGTIILGPNPPAIDFTTHIRVDDGKRTSYQVPPHMLSGHTPTAPASDGQTSSQSVGFDDPRVILETIHRHQAELQCAQVDPPKLPMLSSLCTSNLGVVRHLHDLQKYFIKYDSRFPDSTPSGPQWWVGQANRAIAKVDAYHYWSLVTGTTCVSWEGWCDEFKKKALSPNWESETRRVFEGLQCQGFTLAAWTAFEEKAGECQMVLSDCIGPSPNPTCVENSCLASPRISLPMLRIALKTEALRLASYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMQ0</accession>
    <name>A0A1E3IMQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029604.1">
        <property type="nucleotide sequence ID" value="XM_019178448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMQ0"/>
    <dbReference type="GeneID" id="30195598"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="173"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="428" mass="44843" checksum="01B66E9ABF5FC156" modified="2017-01-18" version="1">MAKSSKSAPAAVPKVEKKEKKSSKKEEKPAAVAPKAEKKEKKEKKSKKAKTPTPPPSSSSESESESDSDSSDSESEEEKPAAAPVAAAKAESSDSSDSDSSDSDDEEEAPKVAAKVEEKKAESSSDSDSDSDSSDEEEEPKANANKRKASEEPAAAPVEAKKPRADGEDEATTNVFVGQLSWNIDNDWLASEFESCGEVVSARVVFDRDTQKSRGFGYVEFANLEASAKALEKDGAEVDGRNIRVNYATKRDNNQAADKRAKVFNDKQSPPAETLWVGSLSFNVTEDQVYEAFGAHGDVQSVRLPTDRETGAPKGFGYVQFASIDEATAALKALNGQEIAGRAIRCDFAPPKQENGDRGGFGGGRGGFGGRGGGRGGGFGGRGGARGGGRGGFQDRGRGGGRGRGAPRSGGARTGGIQEAQGSKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS6</accession>
    <name>A0A1E3INS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029779.1">
        <property type="nucleotide sequence ID" value="XM_019178341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS6"/>
    <dbReference type="GeneID" id="30195487"/>
    <dbReference type="OrthoDB" id="2575884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="37987" checksum="783DA13DFA5018B8" modified="2017-01-18" version="1">MSFIDDIDWDSFLVETDLGEKISANVSPAFSASALSNSTESDQSVALEPEPQNYNFGFGFGAAFNTSSPTGMSHRLENMLSPETIQAQLTNFGLFSGFDSSPEVFPPQPLPAAPVQENTDLYAAITHLVGNAPMAVEPVNLSLPASPVAPVAALGAKRKAFDASDEGAPAPKRRGRPPGTGKPKAAVAPKRRVSKPSPASSSVSPASSLEALPLDDFDDDMSPVRLTATGKPSTDRPKSVVPAKFLKDGSAQAILGMTIPEIMSFPTYEELLKKVRPELVAGATEFGEKIADNRDKAKDAAKKSRDERRAKIERAEFLERRCEELEGKVSNMGSFLMSLVDLKVLSKEQIRAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INT9</accession>
    <name>A0A1E3INT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029791.1">
        <property type="nucleotide sequence ID" value="XM_019178353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INT9"/>
    <dbReference type="GeneID" id="30195499"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="573" mass="64448" checksum="A807E0BD0F039638" modified="2017-01-18" version="1">MLAPGTNKTKVTRSKNGCLVCRSRRVKCDTGKPECERCIKYGAECVYPERKTFNSQKVAEKLHKRHHSSPVAESSASAQSRPRSEIQLQLQPEPSPTPRSVPSSASHHFHPSHMAHQSHHGKPTNVAPLHKIRAMDPFDLLMALCRDTRMGQFFSGPVDPPEFLKEAFPVADDLRCFHHCFTYTLSTFVVHEDPNPWLDHVIPLLLFASGDTPLCTGALRLALLAVGAVHLASLEDKGSAPDTNGHTSRLGLSYRNEAIRLLRMAQHVPVELRSDTFLAASMMVSGADLLGAQPRWREALRLAHASVRFRGGCDAILFGDRGPEPPLPLRVCLIEYLVHVDLLASMTTGDPCVVITESSDWWEKLQSQDSSVLDSIESTTGYHRSIVKLTVRANNILFEACHRSRYISPPSPSSTPTHRPELPQRIIKFCTDLEAWRRDVLPTITDKRTRDGSLALWVGVQILVHRELLGRRREEEVVQKYAVEALDICADVGPKVEYMNWPLLIACTVLYAPPQRQRAREIIKSFMYQCSYELDVLEKVSEECWRRMDEGMDDEACMWREILIEIGSAVMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INU3</accession>
    <name>A0A1E3INU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029795.1">
        <property type="nucleotide sequence ID" value="XM_019178357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INU3"/>
    <dbReference type="GeneID" id="30195503"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="173" mass="19757" checksum="68AA67C7DD33F603" modified="2017-01-18" version="1">MDHFIVRFQCYQQELGLAMEMLVDWEAAHHVPNTWSPIGDTRTSTLKNTWRLKPSSATSSSRYPQCPSPLFIYTAKDLFEFISDLRRQPLMEMLGDVVPDCEYYVFPPNFPIQDSETRLLNMEDEELQGVADATRDVPRAPSDSSRSGPVSALRAMFNKASDCLDKVLDFRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ42</accession>
    <name>A0A1E3IQ42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029804.1">
        <property type="nucleotide sequence ID" value="XM_019178085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ42"/>
    <dbReference type="GeneID" id="30195230"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="190" mass="22379" checksum="2B82C61318DC28A8" modified="2017-01-18" version="1">MGKSQSKLSSEELAELQKNTYFDKKELQQWYKGFLKDCPSGQLNKEEFKKIYRQFFPFGDPSQFADYVFNVFDEDKSGTIEFKEFICALSVTSRGRLDEKLKWAFQLYDINQDGFITYDEMLQIVRSIYKMTGQMVQLPEDEDTPEKRVDKIFRNMDVNKDHQLTYDEFKEGSKLDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS28</accession>
    <name>A0A1E3IS28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_05924</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030036.1">
        <property type="nucleotide sequence ID" value="XM_019177997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS28"/>
    <dbReference type="GeneID" id="30195136"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="610"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN91410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="739" mass="83801" checksum="CDAC49E98B919C54" modified="2017-01-18" version="1">MALRKLQTEIDKTLKAVASGVEVFESTFDKLNHASNTTQKDKLENDLKSQIKKLQRMRDQIKAWLGNGDIKDKTALLENRRLIETQMERFKALEKETKMKAFSKEGLIAQSKLDPAEQAKRDMVDWIGGVTDELSHQIEATEAELEALQQTKKKKKEGERQDELEELNERREWHIGRLEIVQRMLENGGLQVVDVESIEEDVKYFVEANMEDEFDFDNGIYDELNLQEEEDYLHDFGVHEDHEEEDEPEPEPEVEPSPPPKTPAKSTPHRLSKSDKDHEERDEFASPLTKKTPSRKSTVDKEKKEKEKKEEREKKDREREERERERVAEEKHLQAGPTPSKPAPLPPIRYAAAAAAAVGGASASAPSQTTAPLAPESDHVASPQEISSLPPPPPPGLETRSPSQPSVAHYTDSSAPSRAPSLSAASGISATPAQTPGSVAPPPGYPQSAESSHSAQAQLAQAQATAQYQAQQAAQAQAQLQAQQQQQQQAAAAQAAQQAQQAQQQQAGVMGNLMQSFEVAKEICEYECFVCECGWGCVFRYPKGWGAGKGKWKSKKHVHRIEQAGVVPPPPSFMGGDHVQVHGEWMRGGQEAKRRSDDGDELHAALEGSYSNIPQQQDAEPPRYYHPKNPIKTPSHYPQARLPALEDKSIYSRLELDQLFYIFYYMTGTYEQWLAARELKKQSWRFHKQYLTWFQRAHNPQAITSDYEQGGYYYFDWENSWCQRRKSDFRFEYRWLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISF5</accession>
    <name>A0A1E3ISF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030011.1">
        <property type="nucleotide sequence ID" value="XM_019177972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISF5"/>
    <dbReference type="GeneID" id="30195111"/>
    <dbReference type="OrthoDB" id="2564806at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="642" mass="68677" checksum="5241E034D35F4C3E" modified="2017-01-18" version="1">MVIPHIPSFGRKGDRDKDKDVPPPSSDHISPTSTKRPNHQSTGSTSSTVDSPASKYHPIRLLRRKASVSAPKDAPPPTFAGDFDPPVSASSSGSVLESQQTVPPLSSTVGVEEREGSDHEGFKLFPRRKSESKPRRKSRAERPGSASKRAAWVYDRQLHGGDAIEDVPDRPSSQSSGSGGNGDADGDVFGGMGGPVSALGLGEESSQEKYDINARLTTERDYVTGSSRHRRSLTPPDSAPPLHHPFLAPYPTPLSPPRRPGGAIPSSPRALQSFHAQQKKGGRPSTAPSSINETLASPASRPVTPTTVSSPLRKAHPPAASPAPPTSPSPTKSSTSPRPLSQPAQPPRTPVVTAEWLKRKPSSGRLRHTPSLSADNIPLPSNPLAYGTPPRPAKNGSRAKGLDESPRIHMSTARDRNVSSSSTSSSSTDAFSSDGEIGFKSPTRRNISTPTRPPSASRAITLDGSYEVQINCSDDREEMEEMKWEVTIRRRSSRNPSQQPVSPLHLDTTSSTTTAPLTASSINLSLSLDEPTGKLVFISFPMDIHATPTRRRRGSQGGQAGSREKEKVQAQVQQYQASPRNSFGLAQRPVTPPSSNRAGPVTSESEVEEVERLKAETPRPATPTSARRKAPPLWPDSMAQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITU9</accession>
    <name>A0A1E3ITU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030171.1">
        <property type="nucleotide sequence ID" value="XM_019177787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITU9"/>
    <dbReference type="GeneID" id="30194921"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="260" mass="29585" checksum="7F568F314A3F8E19" modified="2017-01-18" version="1">MPQNEYMEEHRKRHGRRMDHEERQRKRTAREAHKNSQDAQKIFGHRAKLLHARRHSEKVQMKKTLKAHDERNVKQKDDGAVKEGALPAFLLDRDGQKDAKALSSAVKDRRKDRAAKYSVPLPKVRGIAEEEMFKVIKTGKSKSKSWKRMVNKATFVGEGFTRKPVKLERFIRPTGLRMTKANVTHPELKTTFQLPILGVKKNPQSPLYTSLGVLTKGTIVEVNVSELGMVTTGGKVVWSKYAQITNNPENDGCINSVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU91</accession>
    <name>A0A1E3IU91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030092.1">
        <property type="nucleotide sequence ID" value="XM_019178053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU91"/>
    <dbReference type="GeneID" id="30195195"/>
    <dbReference type="OrthoDB" id="2596806at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013085433" evidence="2">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="310" mass="30901" checksum="7453684A7BCC15C3" modified="2017-01-18" version="1">MRPLTALVLLPFAFATPHATPSFSIPSPTATATPSLGPTPLPNPTYHQLNERCTSGSCGGPGGESTLEANTITSTIVSTTSVPCYITTFVTDSTTSTSTVYSTSTITSTETKEGTVYIIQYSPTPIVGSTMVESVVEMTVSYLSYWVSSDGSYSESTSTGEYATVGGGGDCEACEQASSSAAAGGSGGSSGSSQDSGWGSGSGGSLSSSNGDDTSSAQTIGSGSADGGSAWTHATNANNAAGISATATAADASNAGWGNSAGSKTAVGTSGSSDGWVNGSAGEKMRPMRRWGVIVAVPLMMAGYWSVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT4</accession>
    <name>A0A1E3IVT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-nucleus import-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030334.1">
        <property type="nucleotide sequence ID" value="XM_019177583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT4"/>
    <dbReference type="GeneID" id="30194714"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="207"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="579"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="94878" checksum="D657CA57F5037075" modified="2017-01-18" version="1">MSRNDKDALVAFVNLFKLSKSVTDFVQLADGKALMEVMNFVDETHFKNVPARAVGPSSSSENWVLRTNTLKRLYRLLLSYPLPAPHPPSLSLSSLPEPPFSSIAKSPSTREGSQGLLHICRLCLVVGVWAPNNENVITKIQRLNEEHMAELMKSIEQIMATMPEEHQGSGQASPLKPSPDMSYSPPPSGLRAERDKLLQENDDLRSRCEQMVGQVSKLTSELDEAKEDRDDAMERLKRNEGPGSGLRTSQNAHTGESDGLKADLLKSEENLAHVEEQLEKQTAHVNELSKEIEQYKAEAEEAVRLKDQLDEFRHTSDRLRKSENVIEKYRKKLEDSAGLRRELRNLEEENATLVNTNSALEADLNKALSSKSLLDTYKSQITTLEKQTSDQSSEIAQLTQQLETAQGQLEVLQQSYDEHEEELAVNLEKLKELELSGGAEGGGGEAWKRGMTRSESGALLGDVSVSLDDELEGIDGGVTESKTEYVQYSASCDQHLTLISLRVKIKSLEREIASLKSFSHTPGSQTELSTVQALLSDATRSRDRYQTDYLTAHRETLRLSAILEAIRSGKGKGGNAAMVEALRKRVEELEEEVIGLGKEKKGVQEGKEEVEKALEGARRDLDMVGKDQRDILASLCENVEKDTTNLEHQVRQLKEQIDILRDRDRQNLEEIKKLLTDKVDLQSAGINQRERALEKEKEFSELRATMSASGVPSETQQQLLNVHERNIELSAEVKTLQEKLLASPSSNTEDHSLFEAAQQAYESQIASLQATLSKLKQSNARSKNLHEMENQLMLGAWHDLGSRVMSAHLQNAGSAAGALGGVGRRSQGKSTPGGWLGRQRRMQEVGGLTRGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWB4</accession>
    <name>A0A1E3IWB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030125.1">
        <property type="nucleotide sequence ID" value="XM_019177741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWB4"/>
    <dbReference type="GeneID" id="30194875"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="10">
        <location>
            <begin position="631"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="8">
        <location>
            <begin position="773"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN91991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119425" checksum="E72017EA238027D4" modified="2017-01-18" version="1">MSQEKTSEGVAKTTTSSKWTEKLHIPDWLEDSWTDRRQWKNFIRCMIATFAPLVLLVCQSSLNVIGQATFFAPLVSQMIPPYMALGIYLFVILTMILGICFGWAWGAAAMATAMRARSQVLLQSQVQAEQAGLADSAAIVDSASIFRGAFLDPRSSAVYGVFLFVGAYGLGFIRAVRPKLTLGLMCTIGPLFPIKQYTLATQLALPAACYFAIAIASVILIFPQTLNHIVLNAFTKTIIAPCIELFDLQEQVLRTSPSDKSKWAELADKTYAIRNKHVSAMTALQEQIGMLQLEITRGQIGPTDTERIFVKSKDLGARLYSITSFVMLIEEQRRSDEEDKEATDPHPHHHTQKHVERLRQLAEPAKSLEGLLPVLADSSADLRESSIKTLRDISDWLFLVNHTRWKKVPADSPPITQREENLENLKRALQEFRVSKQFALLEPFSGFFDPDTGALKSGMLRSFRLTGHDLSRALVLTATIVPFALSLIALLELLLEIERANPKAKIQFPKRFAKMLLKTANDKNGNPNPLDMGLKDTDAATEEERGRVSPEEDDDSDDEDQKHTKPTKKQKSKKTYAKDPDARDPRNSLQHFGRHVYTLWQGLSGTSGVFALKYALVSVALFVPSVCPSSAHFYYVNRGLWALIMSQTGLGVFTGEQINAFIVRMSGTVAGLVIGMLAWYIGSGHGNGNPYGVTAATMVLIAPFLFIRIAAPPSKAVFFLMANVTVMLVVGYSWIDEHIYTTASQGVGAALAGRRALLVIIGFTAAFICMLFPRPTSARALFRRRLAKNMRDISELYGEVVTGIEDEVDAAEWGTAVDENGRRERYKGKFMNILGRMEAMKVHMMYASLEIGLKGPWPKKTYAKLYKVQNEILVTLALLSSAYSRLEVVWCKRLATRSLFMHPAFIGDCLMLFSALQQSLRTGEPLPPMLPIFERLAMHESAGRTIRRQWMSGTTETDLESEAFVNGVDDESEGVNEVQKRKGSDRADRVSKEGTTLSGSVLESDNAAQVMAGLITWENCNSEQFTLCATSSTSLVHITVCLNKMYLIVRELVGERDLSGLDRASARWADMDPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWK4</accession>
    <name>A0A1E3IWK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030215.1">
        <property type="nucleotide sequence ID" value="XM_019177831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWK4"/>
    <dbReference type="GeneID" id="30194965"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="366" mass="40042" checksum="5B2F9043F063950D" modified="2017-01-18" version="1">MISSFRPASKDIELANPPTDSISALEFSPTADILAVASWDNNVRLYDVNSQGQSQGKAMYSHQGPVLDLCWSTDGQYLFSAGCDNSAQMYNVATGQAQQVAQHDAPIKCIQFAEVPGSGQVLITAGWDKKLKYWDLRSPNPIATLDLSDRAYSMDVAQQLLVVATGDRRLHVVNLSNPTAIFKSIESPLKWQTRVVSCFPTGDAFAVGSIEGRIAIQYPGEDDKRNYSFKCHRYDVPTGTMPRTPAVTGSQNVFAINAITFHKVQGTFCSGGSDGSLTFWDGISRTKLKTFSCKDLNNGDTDVRPPRFGTPIVASAFNRTHEIVAYALSYDWSKGHSGVPPSGQTVNKVMLHPVKPEEVNKKPKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY78</accession>
    <name>A0A1E3IY78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030688.1">
        <property type="nucleotide sequence ID" value="XM_019177535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY78"/>
    <dbReference type="GeneID" id="30194665"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="73" mass="8415" checksum="12EFCD0E8BD0494C" modified="2017-01-18" version="1">MSEKQACHPEACAIQSCIMKNNYDESRCQKQIEALYRCCSNMYETAEREGKNPESDSCPLKSVVERRMKSFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYA1</accession>
    <name>A0A1E3IYA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor TFIIE subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030674.1">
        <property type="nucleotide sequence ID" value="XM_019177521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYA1"/>
    <dbReference type="GeneID" id="30194649"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFA2 Winged helix" evidence="2">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="32319" checksum="3D13DD077EEA9206" modified="2017-01-18" version="1">MPSWAQYSEPGTPGARSAKDEPQDEPDVKPDIKRVKTHLSGNHGMYQDTRTAAIDLLNILRKSVTMRYEDAYFRVQENSPGTDPTKALEILKGLERIEFNAGNQVFSYIPELTLITASEIRNHIRVHSTPTSGLPLKTLKEAMPNGVEPLKDLESRGDVMIMRGLGANFKDIPLPRLGRLNVNGEDLLSGPTTRWKMVFWDHLKEAGRAGKRVDDEFIFSWADVPIAETDDVTKLLADQELSASSLTPAAPKAVAAAPAKKKKRNTRALKITNTHMKEQGIDFSKDYVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZU1</accession>
    <name>A0A1E3IZU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030531.1">
        <property type="nucleotide sequence ID" value="XM_019177378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZU1"/>
    <dbReference type="GeneID" id="30194504"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="71" mass="7727" checksum="B96F81E800EF0422" modified="2017-01-18" version="1">MSILARSTLAAARTVRAAPRQVRAAHFENVVDHTLPTSVNKYSLAAKMVVFTIAGFGTPFLGAWWQLVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZY1</accession>
    <name>A0A1E3IZY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA dimethylallyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030724.1">
        <property type="nucleotide sequence ID" value="XM_019177143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZY1"/>
    <dbReference type="GeneID" id="30194257"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59561" checksum="CEDE3063C305D0A1" modified="2017-01-18" version="1">MPRRTSADHRNVVAVIGTTGVGKSQLAVSLAQSHQRFSKGHSAAVVLSADSMQLYKGLDVITNKVTKEEMGGVEHWGLDVVSPAAGRSWEVGKWCNEADQEIANMPLETLPIVCGGTHYFIQHFLFPPPELSFSREDSDGQGRPLEIRWFPPGPTPPTPENLTPALKRLLESFWLPDPVWPSAELETPSSPSTKAESSKSSRPTVQDEYNLLSLFRLLEAVDPTEAGRWHWKDGRKVRRGLERWWERGGRVNQKNTDVLESEARPPGKDGRHAKFRTLIFWVYEPLVSLRPRLDKRVDKMLENGLLQEIEELRGIAAELFGSDNPVDHTEGIFQSIGKSRSRLQTTIYSQKSCQDTKNPQSHPLFPAMLERTKISTHQYAKSQISWIKKQLLPAVREARSLGGQVEVYVVPGGEKGEKPAVDVLSRFLKEEHLPDASAIGHPDAGELRQSLNARKFCDICSTPNQPYSVIVRDWDAHLKSKIHNRNSRSYDKSDREAWIAEQRAKAEQRRAEKERSREESVQQQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0A8</accession>
    <name>A0A1E3J0A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysophospholipid acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030773.1">
        <property type="nucleotide sequence ID" value="XM_019177192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0A8"/>
    <dbReference type="GeneID" id="30194310"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="583" mass="65159" checksum="41D6425C657B0D05" modified="2017-01-18" version="1">MFWDPAFNNASAIVGAPPDQLKLIFSLLVSYPLGSLYIRLPSSRPYVAHLFSIVLSTVFLVPLLGLGGGMLHLLFSSLGTYAIVKYMKGTNMPWVAFCFVMGHLLFNHLKRSYLGLSSSSIEISGSQMVLVMKLSTFAWNVHDGRSKDEDLDTSQRETKLTDLPGLIPFLGYCFFFPSILVGPSFDYATYDALVHHRLYKIAPPGTSPEQAAAVKTRIPYGRKRVAYLHLVIGLSFLGLYATYGGKFSYEQILRKEFLGYKVLQKFGFVQLCGLFARTKYYAVWSLSEGACVLTGLGFNGYDPKTGRTLWNRVRNINIKGIETAESWKVLFDSWNCRTNVWLRDSVYKRLTKKGQKGGTKESMATFLTSAFWHGIDPGYYLAFFMGGVFQSLGRQSRRFIRPYFMPVEGSTIAPAKRLYDVAGWLFVQANLNYLVAPFLLLDFKDSVGAWGRMYWYGHIAAFSTLAFMSLGGRRALKNGLRSRKPAVPPPSLRVSPPSPPLLAPEIPPPAPEDEKDSRDLRWVKHALDNPEYQDDGEGVGMGVAIPDHGFIDRWIEGAETPATGMSRVSTPKNEAGDPLVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0G5</accession>
    <name>A0A1E3J0G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030839.1">
        <property type="nucleotide sequence ID" value="XM_019177258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194377"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="59"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="885"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1235"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1456"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1602"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="498"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="588"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1298"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1457"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1479"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1523"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1603"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1677" mass="184293" checksum="0BBE3087023AFA28" modified="2017-01-18" version="1">MLAARRQSMASPGPLSPSSLPRPHSSTGHHNYGQLRTRLSSDAASVAAAALNDVPETRNVKVVLRVRPSNPDDASIPARYRSVLVHPTSETEIRVDVDPATLAGHAGTVGSSRKHPTFTFDNVLGEDSVQTDLYDATAGENVDEFMKGHNVTFLAYGQTSSGKSYSMGTTGEDTDYSGTNFTPRTGLIPRTVQTILERAEESKQQAGPGASWEARISFLELYNEEIIDLLSGTGISISIREERDGRIVWSGVREAKVKSLAEVMQLLQEGSARRKTSETNMNSSSSRSHAIFSLTLVQKRIAGPMSSAVASSRSETPTRQLRRPSSMMGISSAGSARSPTPTSGRGGGPPSSFGRMTPSRPTSVIGTPTGADDYIIVTSKFNMVDLAGSERLKRTAAQGDRMKEGISINSGLLALGNVISTLCDPVKARGHIPYRDSKLTRMLQDSIGGNALTTMIACVSPIEANIGETLNTIKYASRARNIRNQTKVNAVEAGWDDVEHLQTTVLKLRKQISMLESDSKGSASEGNSKHSEKLIQRLAELQREHTELYDRYLAKCSDNMRLGSELRNRGPGDGDALSKFNETVEPVILEYEKVVSALNQQLDELRGEIVIINDLSEEHNRQLEEARDRQLQSESYVTELRSRLTKLTERNSSSEAYIQDLEAKLKMYADKEDSHADAVAELKKDISKLRENNASSVSNAQELEAKLSRSEAASSKLVAQVEKQEEDAQVRESAYRELEAHIVRLEAQSLEDSKRLLGELSDRDDKILELEEELEKQRLDGSRENKLLEAVNAEKAAQQELRIRLASMQKSASGVVTPPSEGSTPAGSVIKKSAASSNGGEGEPIGELEQLRAAFEKLAAEHAKSESHIADLTSQLSEAKLVQGEMEDTMPLSPSSPIIDHDSHSDDELEEVATPVDDLPTPARSAPGSSPTKRRTSSASMRRSSLPLLNNGVAVKMGFRGGRGFSDSTRIRPQSLSQELSSAQSSVSSPRATWRDPNTNKLLLSSPSMVPKPSSKSVQSLEAELRFVHGIVDERDEELRDREAYIRQLEEQLELSKTHDILSRKNRANPIDVTTSEIESIDTEVVELPRTPETPGIQLQPSDFPLPPSPAPMTPFKSLKVEAGDQDGDDEGLKPPPDDGENGALSPRSVKRFSQLAESLSRLESKEGCNEQDMIQELMREMAEKEASQRRIIEQQFIQIADLQKSNNKLKEELIEVEPQLSSIQKLRSERDLLTAEKAAATSPSPSPVPSPSRSIHSLASSAALDRLQEEHSEDLQSIITGHSQTIKVIQREHQDEIAKLQAIIEKNEAVIEEWAAKVEGLKLEHHGAQTAQRLDQEAKEAAHQKKLDWLKADHAEILASLKDAHARALEDLQSEQDLIAQEMESSLSSSEEQRRQLKMKADQALFELSRVRDEHSLQQNGDAKQISELTKANAQLEKVKTELEHANAELKGQCADLKHQTGDKRATELEQRFSRKLVPPPQVPPPTTPLPPLPRSSSGHGTRLGSDGASITPSMPQIGETVGQSRRQSESSAGHSDGSGEGGSQAALYGALAERDGLRDALVKDKERIKEIERELQGEKVKIKNLTVDLREAQKQANTIRSHLDEARQENKRSALSCREHTSELEARREQMAKLAEQERNHRDSLQASQAQVASLKLQLERAVETKVQKRGFMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1E5</accession>
    <name>A0A1E3J1E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030927.1">
        <property type="nucleotide sequence ID" value="XM_019176895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1E5"/>
    <dbReference type="GeneID" id="30194001"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="35603" checksum="5936E37790751826" modified="2017-01-18" version="1">MSLNHHIPKKISLKPKAHHGFQFVLWLLGLLLPPLAVAVRFGIGVDFFINVFLCICGYIPCHIHNFYIQNIRNNQNRARTPKWAIKYGLVDNSNNERRAQKNLWAKRFEERNNHSTLTDQELEAGEEGPNYDPYAESPAEVERRRNEGLWSAEDEEYYNADRAPNQKSWHYPANFEGTVGDGRSYKRKGKSSGSSGGDRWQRAARRSSVSSSTNTYPPTAATEDDIPEWGRDYGSKGRKSGKKQQKAAAKKNGGENEWARNPEFNYSNERAGAGYSNGAGGGGGRRRGDSGASAGRGGGGKSNGNAAAAPSGNGDPNWDHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1I8</accession>
    <name>A0A1E3J1I8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04835</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030973.1">
        <property type="nucleotide sequence ID" value="XM_019176941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1I8"/>
    <dbReference type="GeneID" id="30194048"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="643"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN94694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="710" mass="77136" checksum="5FD228819E15A306" modified="2017-01-18" version="1">MRILTWNVNVLRTCLDYHPFSGLPKKNVEGLLDHLDAEIMCFQEHKTPRAKLEKSMACPGPYDGFWTFPRSKTGYSGVCTYVDSRYCVPFKAEEGITGILLGDRLSTMKPPWTEEERIGSYPDVDSMRWDPEADGGEFDVKKLDMEGRAVVCDFGLFVLFNLYCPNETNDTRRPYKMNFHYALHERVRLLQAAGRQVIIVGDINIVRAPADSGEGPVRSSAAQHYEHPARRMLDDWCAPKGEMVDVVRESWPRRDDMFTCWNTKLDARSSNYGSRIDYILCTPGLRPWIKGGDILPKVYGSDHCPVYIDLHESITLPSGETLHLRDQLNPPDRPPSTAPVYPNAVRREAPEPPRFATKFLDEFSGKQTTLKSFFGGGGAKKVVERGQGKEKSSALPKTSASPAPPPAPSPLASAPVGGDTPAPPVPKSVPVLTPAGEEPMSAPLSLAKSAFSSLDSPTPVLPSAEPGDKSASQAGKASTTATTAPASSKAKGKAKATSGPIDMTFSDSDEEPVSTSASKPKATTKPAKGGSNARGESESSQAKLSSFFSQPSNNAKRKSPPISSSSSKSKARRQSLSQTPSKTPAPSVSQSSTTQLKESGLSEEEQNLISQALATSEAEREAKIATAAPRWDQLFAKKVAPLCSVHQKPCKDFIVGKPGPNKGKRFWLCSLPVGAGYDMGRSKRARVDVNPKFRCDLYVSISTGALDRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N9</accession>
    <name>A0A1E3J1N9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031062.1">
        <property type="nucleotide sequence ID" value="XM_019177030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N9"/>
    <dbReference type="GeneID" id="30194140"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="376" mass="41801" checksum="03FCAFF2D5250B29" modified="2017-01-18" version="1">MSTTNTSATSIRQPKDIECWGHRGASAHLPENTLASFRAAISEGCDGIESDVHATSDGVVLMFHDPTLDRTTTGKGLIKNQPYKDVIEHVRTVKEPVQPIPLFEELVALIMEPENRHVSLNIDCKMQNDPQRLFPEMARIVTSYPNYEKDLSPRIILGLWHPLFIHPAIKYLPHCRRFHIGFSIPIVKQFFWDTCEGFSMAFPLLMGKEGQVFIKECREQGKEVTVWTVNDEAEMRVAMSMGVKAILTDKVGVFVNLKKEMVEHPEKLPLQGLEAWTFPWSHWKYYSVAHVTARLASKMFLKAHGSLSTPPSPSDDPEPPTSIPNLPFPAPAPDSSFGDAASTPTAPSPSPSTTTNDPTLSPTVSIARALLPRDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1S6</accession>
    <name>A0A1E3J1S6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031063.1">
        <property type="nucleotide sequence ID" value="XM_019177031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1S6"/>
    <dbReference type="GeneID" id="30194141"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130072" evidence="2">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="424" mass="46411" checksum="88490C97F92E2760" modified="2017-01-18" version="1">MTIQGLRRPLLTLFALLGAAQALPAVQLPLTLSPHFLMEEYELHLLAINVQYTIPTVLHGPTDPRAVYTFLDDHTLATLSPSSPASPSSSRLREASRDKKPEVTRWELVVQKLNYTSLPSAYPPSLGREKLVRRVELERPPEKLLYSPQNGALVIVLSAPQALEGEERKEETEGNGPVVQVHLALGDNGQWTTKSKLENPLKNTGLIVLEATIRGPILAFSALNSSLSIPSSSSILYTLDMSSHKLTQISSAHQGSANSPVISSEGKIAWLNQPPLHAGNKRVGEVRRAREVRRALWLSDDVDGKSRAVGLQDFELSPTGVVFSKDGKAINLLTPHDNSASLFHIWTPSSRSSPPAKPVRIPSNGTIYDAVHVGITPLDHSHLIGSMSEKTDGKGKELWVISHSPHEDPADNYENIRLTWFTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1U8</accession>
    <name>A0A1E3J1U8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031126.1">
        <property type="nucleotide sequence ID" value="XM_019177094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1U8"/>
    <dbReference type="GeneID" id="30194208"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="470" mass="51652" checksum="F514C6BD5BDEDE19" modified="2017-01-18" version="1">MAQQSEPVSLRLPAILQNPTNRAARQVEAHNAQQRQKAAARKDREYNVNWTPENNGKGKRVIRRLDNAAFAENPHIVRPDRSDYAPTVPLHPRPSRPLFPPGAISRSTHIPPAALPEREPFSADARQGVFSTSLKGTRAMLRKRGKRAEGLVMKSESEIRAWLGGQWGDIEQSADQWTVVDPRFVDYTPGETSTLSRSRRQLPPQHQIVTLPDLPITDGQIPAILEVSRSPAHMSWYVPESFDRLVLHLISRYYELVSWSEDLPTRSGDHLRITHIAVPFVIRPNRQPVKGHTLATPDTSEVSGQSSSDHNSSSSSGTESSDDDTATERGDDDDDYNPEGDITATPIPEMEDLSLADNASENGLTRTLSATSSQYASSEADSDIGALGDSLMLPRPASGQESDGSLAGGWVDLDSDSEFGDLPALPSLNGVREAPSFRRSGVSSQTVPEDWAHKPSFFEYLYGAQRLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J309</accession>
    <name>A0A1E3J309_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xenobiotic reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031214.1">
        <property type="nucleotide sequence ID" value="XM_019176739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J309"/>
    <dbReference type="GeneID" id="30193835"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39252" checksum="D38AD26F93EAD3D4" modified="2017-01-18" version="1">MSKYPALAEPVTLGALQLPHRVIMSSLTRNRSLPTTVPNDDNVKYYAQRANPETGASLILSEGTLISHQGTEWPYAPGIWDETHAAGWKKVTDAVHAQGGQIVAQIWHTGRTCHPDMPEQSVGGEPVWAPSAIGARGGKFRLLPGQPGYISNPTPIPDPTVILDQYTNAAKMAKLANFDGVELHSGNGYLCEQFLSDVSNVRTDKWGGSVENRARFGLEATKRLIDVWGADRVGIKISPLGGYNDTYNTTPESRIETFRYYVSALDDLSLAYIQIMASTFGDPCHGGVPQGFDHDIFEHYGPLIKKSNLIANAEFDAAKGEEAVKSGKAKAIVFGRPFVANPDFYSRAQNGIALAEPDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3R9</accession>
    <name>A0A1E3J3R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recyclin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031045.1">
        <property type="nucleotide sequence ID" value="XM_019177013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3R9"/>
    <dbReference type="GeneID" id="30194123"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="348"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112298" checksum="E7BA03C8DBE4681A" modified="2017-01-18" version="1">MDKWAPIAPSNPSTSTAHLSSRFASVLKPTKPGAHNAKSSGPLIGRWPEDVLLRIVELAPVCDLPNMARANRAFAKIVKDERGWEWRCKLLGLKPESKPPTLSPRRDQTLKTSPLRPKKTSFSAQHSSPLIDDDFGDFSGQNNDTFEDVDFGDFEVGKSAGSPDPGVSSGGPKEANLLDFDDLPLPSRPTGKQGGQARTTGFFALTPSAPRHVVAFPSSAPGAFYNAYKQHHLSLVPLCHHLRSSPSPSSTLALLFPPSPITSLPPSLPKQSEVLLSLLLFLTPQLQPLHDWGFLRQALLTAADRFDSTCLVAFEVADGRKDEEGMKVAAESSWAVWEAGGGKREQWECGRVWVEKREVFYDSAKWDSAENIIKAQMPAGGTTRQLDFTPMDAFISHVLEAFKIDAETAHRVFPVNARVILSFCDRLANEVIGDYIHPLLSQARAVSQALFLRATAATFVQSWKLVDVVMEVLGSKQKVITREQVEDSVFKMFEEHLDEYLDDETEWVQQHLEDICRAWETQLGTSDSPTQTKSTPTFLTSSNPDQVKRNVLASFKDALLLPVTIVPRTVTFGVNAIVTGGTQAVNGLAMLNPQKWTGKNGAVKEGEEGGVVFEVSDVDEKAAGDMGAVDVGAGIEETEDAEEVKEALDTSLAVPETNGHSSSPSQLNPRSVTPDPSDDKSFDRLQLLVSLDTALELIQVDRDSLKRAETFARYPGKAGYKVRDAIEEVFILLLKAAGDRHIAPGFRIATNQMSTYKPAEHEETTSVAPLLQFFELVHIGDTIQSMVQVYFDQELSPYVDKTDFLNAVMREKKRFEGVLDDAVAAGLNAGIEVLMNQVEHIIQVKTAPREYYPEADKPLDLGPTEGCKEAVRCLEMHCNLLRGSTSKDVLEVFYQEVGIRLETIIQRHLKRQIISLEGGFQIIADLNAYYAFVASLKQQRITEDFSNLKMLGNVFIVSDAKDLAQIVRDVTRYGGTFTPEDIYEFIQRRADWKKIEKTVDKAMYALSVREDCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4K9</accession>
    <name>A0A1E3J4K9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031454.1">
        <property type="nucleotide sequence ID" value="XM_019176526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4K9"/>
    <dbReference type="GeneID" id="30193620"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="51797" checksum="8F3A081273059FC6" modified="2017-01-18" version="1">MHALKSQWHRLGGSKGKAPYRPDQGDEKRLVVGHFMLGNTYPFTADDWQATFDLAEDTLLDAIVLNIGPEEWQLTQAQLAYELASSRRIKLLLSLDMNVLPHSPDELSSRVVTAINAGRTSQLLWDDKPVLSTFSGHEFGDENWVETLRLISRGLEQQVMFWPAFFMPPSDFMAKPYVDGAYAWISGWAMDNTSMSLKVDQPFLKGDKPYMAAISPLFFTHYGTEGDWAWNKNWIYPSDNLLLPNRFLGFISPHTRTPTPQIIQLISLNDYGESHYLFPVRGAQPGSDAWTEGMDHEGFRIMCKYFIGRWKNGLSEGEELDDGHEGKVVIWYRTKPKDGVYDDAVGRPDRAEWASLLSLHLSIGSLTITQAEDLINLFILLPSHSAHYTLHLTNGPASHTRSLKSGRLNLLTLPFIPGNVHYSIMKKEGSAERVILEGDGKEITEGGAWNFNMWSGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4U0</accession>
    <name>A0A1E3J4U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031522.1">
        <property type="nucleotide sequence ID" value="XM_019176594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4U0"/>
    <dbReference type="GeneID" id="30193689"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="15495" checksum="D9A4836F06B215FF" modified="2017-01-18" version="1">MCECHQVTPDTEKQPPCASCASLSYPPTPTSTPHTPPTHRRTLSQRHLYILLAALVLVTAALAGGAYAIHQHVSHRKLQDATTSIIADSTASPSDTVSATSSVAGADESGYHESGWNSGAGSSPNSGVWFAEVGEEGEETKLERNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Y7</accession>
    <name>A0A1E3J4Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031166.1">
        <property type="nucleotide sequence ID" value="XM_019176691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Y7"/>
    <dbReference type="GeneID" id="30193786"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="433"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN95186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="674" mass="75372" checksum="A74E1B17B09EEC5D" modified="2017-01-18" version="1">MADQNFSAALTTWKEINLSDLQKTLDTTAVELVDNQKENLVGRKKLAEQTREFKKLPDDAEKFSAIKVLLKAYQGEIDSLTRRSKMSETSFLNVYKLLADAPDPYPLLDAAVDQTVKVAEARMMESEMARLKEENAELKKTVGEMSGLEDKRKKAEGKVEQLEAKMDDLIQERVTQKENELNAEYDERMRNYEDREKGLHRQVETVKQQLRDLHTSNESAEAKLLNASQRQEQDVAARLAELDMVAADLARANERVATVERRNELLRSEVESVRSGSQQAEKVKSLESQITELELETSRILATLDSAKDAKAQAEKRAKKQAEDAQAVIDAQKGEVEGLKERLKGYADYDEVKRELEIMKYVEFSGADFGDDGEDDDEPHLPDPNATVANKQQVQSLESLLVSKNRRLLEDLTKLRVSWEELSGEHAKADDVIEGLQVDLARQRELVEKLEGDLMMLDGKEDRGGSGTPVGLAGLDIGGKTENRSSPAPSAQDTSILPIVTSQRDRFRQRNAELEEELRKQFETISDLRAEVKALQADNLKLYEKVRYMGSYRDTASAGAGSSSYPPSSSRGGGLLNGVLGRRDEEIGKYKDKYDESLNPFEAFKGREAQRAVQALNPLDKGVFALTRAIVGNKRARNLFILYAGSLHALILFVLWNGMAASDSSSHPPVTIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J512</accession>
    <name>A0A1E3J512_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031592.1">
        <property type="nucleotide sequence ID" value="XM_019176664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J512"/>
    <dbReference type="GeneID" id="30193759"/>
    <dbReference type="OrthoDB" id="2575743at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="230" mass="25998" checksum="662D494DFE644181" modified="2017-01-18" version="1">MLSSGEYVLADADFQTSTHVLALFEREETDKQITGRNAYFNHIAIPTRTIPEQALDILSSRWRILKHARVSTRVDTDDDFMNLVVDACIVLHNMLLDTGDIYVVIDTDSDSVSRPSWDAAGKGLEKGITTCGKHSEYDMGDAINKNDAEAEALYDRALEAHRESLPKRREESRYPQGRGYKRELILPETYDPKRYKVPEGTPDSSRRHQHLISEMVLNEASGFDAKGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5H1</accession>
    <name>A0A1E3J5H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031336.1">
        <property type="nucleotide sequence ID" value="XM_019176861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5H1"/>
    <dbReference type="GeneID" id="30193965"/>
    <dbReference type="OrthoDB" id="3366674at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="423" mass="46516" checksum="B60309F53302D7AE" modified="2017-01-18" version="1">MPAFPSINTPADHPANVGTLPNAATVDVVVATQAPAPKSAPKEWTRRDTFIMLNQFLSFRQGRGPYIKNYQTFHCQTVISLIKEAGGPQRTVKAVQGRLDTLRKQFGILRHLREQSGFGWNPELQVVTTDEAVWEDMPKKYRVWKNVPFPYYDVSSEQRQLGEGGGDLAFEGEWESDHEGEEEEMPKKYRVWKNVPFPYYDVMMEIEEGGGGATGEGVLVILLDPLASQGDAQTPMGNVIEGEGLSPPWEWADEEDSQDMQGTPASAPTPSLRHISATDSTGSLASTPKSSDLKPSPTTSRNKRKAAAIDQEQDAVQVIIDIIQRREPNAQARARVMQESSDVVWEFLQQKAVEDVISLDDVLLLLGAAQRNPADARSIVSLSRHPGPITNDVLQMCVRSVRATGTVNTPPLITSAIITSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J683</accession>
    <name>A0A1E3J683_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031613.1">
        <property type="nucleotide sequence ID" value="XM_019176203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J683"/>
    <dbReference type="GeneID" id="30193294"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="184"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="501" mass="54239" checksum="05451F65BDF790C6" modified="2017-01-18" version="1">MNTARPWAQLTPAQSLVDQACDPTLAAPNQIANIELAEYINRKKANSARDATSALLPHINSRNPNEALLALNVLDHLVKNCGYAIHLQISTKEFLNELVRRFPERPPMVVGRVMSKILDLLHEWKNTLCVHSKYKEDLVHIRDMHRLLSYKGYRFKSFDAARAMADANPNENLKSPEELEKEDRDAKSAKLQELIRRGTPRDLAAAQELMKALAGAEPDKAIDYTAQTLKELDKVQSKAILLNDMLNNATEGEKIGIEGDVYDQVAGACRGARPKIVKWIEDDNGEKEGMMDRLLLCNDLINTALERFEACKAGDWTRARAVVESSNPNQKAADLISFDAFDDEPAPSGAAGGLSLPADSSSNAGMSTAGLPLDLFAPSPAATPSPAASSSFNNTSQRQDPMAFFNTPQPPAQPAQAWGQPQQSASANFGAFGGLGQLQQPAASSSSSSFGFQPSQSSTPVGYSLSPQQAQPQAATNAQQGQQQGQGQKKDVFADLVDLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S5</accession>
    <name>A0A1E3J6S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TIGR00297 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031621.1">
        <property type="nucleotide sequence ID" value="XM_019176211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6S5"/>
    <dbReference type="GeneID" id="30193302"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN96375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="30906" checksum="2D9A35645E0E5C25" modified="2017-01-18" version="1">MSQPAVYPEALVVAAGLGLHGYQKGSLSLDGAIAAFAVGYGHLANPLKLFGVTMIGMYLLGSRATKVKAEVKAKLEDGPDPSKPSGNRNLTQVLSNSLPGLIAALLYRFGPGGQLSKRSMILSLHPIARPLMFASLGLNATILADTLASELGILSPTAPRYILNLQPVPPGTNGGVSPLGILVSVAGGVFMGLIQVVDLLIENPASRAGGVGWALEIVGLGAALGLAGSLLDSLLGATLQISYYDTKEKRVITDTSEKYASVRTAEGVKTVGIGSNVLSNSAVNFVCGCALAGTGWYYGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J7G8</accession>
    <name>A0A1E3J7G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031546.1">
        <property type="nucleotide sequence ID" value="XM_019176618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193713"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1399"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1614"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1658"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1668"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1759" mass="196744" checksum="BFA1E1C3C31EEDF5" modified="2017-01-18" version="1">MSIGNPNGQPKGDFAGLVSDLMRHKHAEKGAKGVNGDATPSKSSIGLAVSRHLPATGFKKNTEENREKNEGRQGTGVERQESGWSSSSSLPSDAEGRTDSRSQQQKEDEQEGAEGRGPGRHESFIPDGHDDQRPIHDSPVEELSSYPSVPQPRANGQREGSGTSERMIRIDDSAKGSRDRERERDETELMSRSPSAKRQLTDELGRSPVENPGMKEEEVPGPRNEIALGPRITHIHYHEEREPTVDGIHHGPILKVTSDGEAELPPGQTPQASRRPSASQEYRSTSSNDLHAYENGMGNTISDGTWRNALQSSRQKKKGKTPASSRFSSFREDGITTGESDAEGNHGDNEAPDTPTDAAQKRWSMLRHRVLPSKTSVNGPTPNKVSALAPTVIASVPVTTELFAGQLPVMILKTWIDRDENGKKAVPVLLGNLRFRVGDSVGLKQGKATGKEMFKVECEYGDGAVKWVIYRELRDFLSLHAHYKAANFGTSVAGLRSTRHVEIPDFPRMSVPFFNKFDKQAHGKEKERESKEAKETKEQMKISKNMGKAEYAQASRDALQRYLVDLIRAVIFRPESNRLCKFFELSALTLSLAPRGGFQGKAGFLMIPGSNASRRANQPGLMPASWKASREPKWFIVRDSYCVATDGPETTDLYEVFLFDPDFTIIRPKRYYRTGMGILHPHKKDREDDEIANHVDADNPFTKEVMIASGEGKGSKAQNLQDETEHEASQHTFYIVNSQIKLKLVAKNARQMHQYIVSMERIAAQCAWTKKNRFDSFAPLRVNVAAQWLVDGRDYFWNLSRAINMAKDRIYIHDWWISPELYLRRPGNERYRLDNLLKRKAEEGVKIFIIIYNEVSDKTTPVDSTYTKRSLMNLHPNILVQRSPSHFQTGTFYWSHHEKLCVIDETIAFMGGLDLCYGRWDTPQHVLLDEKHTADDGPDGPVWRGKDYSNERVMEYANLDKPFEDMFDRTKIPRMPWHDTALQIVGQPARDLCRHFVQRWNLLIRTKNHTRRMPFLLPPADFTDRELQDLKLQGTCEVQICRSVGPWSMGTQTKIEHSIQNAYCKSIETSEHFVYIENQFFITSTVVDGVRVENGIGDALVNRIIRAHKESDAWRACIVIPLLPGYTYPLDSNEASSVRLILECQNRTIARGTSSIFSRLRKEGIDPDDYITFFSLRGWGKFDSGVLTTEQVYIHGKTMIVDDRLVLTGSANINERSQRGDRDSELLAVVRDTDMIDGTMAGRPYKVGRYAHTLRVRLMREHIGVDVDGIDEEQLMSREPMADADDIETWDPDHEQQSDDDDRGGTTQIKRRLATDRMIGTFQNGVSSVTKGMSENAISNVKRAADKVLHPIAVAKSGETVALNDGGANPSEREDFNPHGKIDKGFASSMVPTLEEKTIYERRPDQSHANGKPLFDHIDERGEDGQVGQAKSGKGDDEPGEAEVPTETKKSGLIVDSDGAKVSGVPRLRGKVSDTELYGTPANVPGDNDKIPVHDTDRTVENEDEEAIDEMNAAVKARKTLRKHLSAKVQMSPWSMATPTPQINPARFHDPLDGSFWKDVWVASAVHNTEIFRKVFRCIPDDLVTSWAQYKAFANHAEKFNKAPEEVAANGQDEPVKVTHDGPGTHGAGGGGSGGGQIGSHGDESSGSKAETSDADVVDGKPRDVPHPHHPHVSRPGHHSEGSKSSFRGGESKRETEREKKASGPDEGWAEWEKEEMELLLNEVKGHLVIYPNRFLEGEDLANNFLFNSDKILPLPIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Y7</accession>
    <name>A0A1E3J8Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_03875</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031914.1">
        <property type="nucleotide sequence ID" value="XM_019176001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Y7"/>
    <dbReference type="GeneID" id="30193088"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130191" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN97312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="459" mass="47266" checksum="29FFA4C7CD6FBCE4" modified="2017-01-18" version="1">MPSFLVNKVALATLAGLAALPSALAHGHVTSWQIGDTTYAGFNPSNSAELGSTPERATTNSDQGYADYTTDVVATGGTATSSDLVANATAGDTVIVTWNTWPESHKGPVTQWMAHCPDDLCAGTAGADMDWFKISQSSYDESSDSWPTDYIAKNLIWTFTLPTNLAAGQYLLRHELLAMHTTGAVSHFLPQFYPVAIEMQLESSGSTTPSPTGTFPDMYNSDDDMALTQNIYGGSALNAEFVVPGVAVYDGSDATVSNWDSTGLENDSTSSSSATASSAVSATTSSAGASATTSSAETLVETSAAESSIQSSAVETSAVETSAIETSAVETSAAATTTNAVSEAATSTCASASATASGASGTNLQTYTGAIDGISAPSVTADGDQYTCNGNTFNSKSDALTRSCDVQRNQCLDSANSKANDQVSAAMTACETQATECDASVSSARRRDMVIGRYAKRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J914</accession>
    <name>A0A1E3J914_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031934.1">
        <property type="nucleotide sequence ID" value="XM_019176021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J914"/>
    <dbReference type="GeneID" id="30193108"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59465" checksum="E4375DF1496B4C8B" modified="2017-01-18" version="1">MSSDVKTLHHLTNVEQLDDFPGEKQLEAENGNTVTVQEVKVAEEALDGQEVYTEEQYNRVKRKVDFVLLPLMWWCYGIQQTDKTGLGSMNLYGVQADTGMHGNQYSLLTVVFYTAYALFEFPSNIILQRFNMGLCLTIYMFCWGVVVLAQGFLHSWAPFMVLRFLQGAFECTISPGFNLLIANWYTTQEHNARSLVFQSANAGWGVVVDLTMYGIAQAAAKNEGGFEAWRGIAVFLGGQTLLAAFVAYWMLGSPNEVRWLSQEEKKIANARVMKNNAGTDLTGRKTWKWDQVREAFLDPVLYAQFVNAFLSSVCNGSLTTFGSVVNRSFGFTESEVILYSIPRSVVSVLWFAFIGIMTSKFKGIRMYFMMISTVFPFIGLLFLALLPADTSYRWIKWGMYLMTVTFVIPLFSAWALLSSNTAGRTKRSIISSMTFIAYCTGNIAGSQVMKSKDAPRYIPGTIAIAACMAAEFVVIIMWRIWLGYLNRKKLRNMQEMGLSDDEIERKGQELGAEDTTDMKNPFFLYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JAW4</accession>
    <name>A0A1E3JAW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031858.1">
        <property type="nucleotide sequence ID" value="XM_019175945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JAW4"/>
    <dbReference type="GeneID" id="30193032"/>
    <dbReference type="OrthoDB" id="2575758at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="536" mass="58346" checksum="73D790194E00D284" modified="2017-01-18" version="1">MASTTYNGPFLPPIHTSFTPLLSSPTDLITSQELHSALDRNLSDSFESLHDLYQVNEEEAEEDWTEESDQIQVYRDTKPLRVRKKKGRSTKVIYVANRRRSTIVSVPRSPLSPKSPVSPRSPTSFDSDSAHAHISKIFPSLPEPSPTMAVPLVYQPNRLAPVTSTDRQGNRSSGSSLHLGLGGSSSYDPICPGPSPPSSPIPSPNKRHFTSPTMYESSERPRKPLPAVPSSPITPSRAPRKAAKLLGVDLPPVMEQEKKKNYAASALKAGRHFRPLPNVALAEIEKFFGEVPKKASKSHPGLKTGKKASNSFYKGNSAHGVPEACDRNIGEGQTVDHRGEDGSMWLDVEEEQEFAWLMSEAIAAVPAPLPSVDDLSESIGGTFPVKRRDRCIDDMSTLCGSDEEEDSGKWGMEAFTSILSVPKPKASRASPSSSPSPSKSRPKPLPLVRRANKSNPDSSFMEIETPKRLDFSFDISPARDLISFFEPVTPVERMGPMYGGGAGPGAAAGTKGKGWLKRAMKPLRSQSREAGPRVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU3</accession>
    <name>A0A1E3JBU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032212.1">
        <property type="nucleotide sequence ID" value="XM_019175722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU3"/>
    <dbReference type="GeneID" id="30192807"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="38616" checksum="00388A7A3A1487FC" modified="2017-01-18" version="1">MLPPRFNQPQERPPSNPASHPDDAIRLTDDDAASSRLSATQLGYLPDPFVSLLYRAPMAHGAAPSGRAARKPPLINIGTHHRTWGIDLLVEQFLERGGKQIVSLGAGSDTRFWRLMSRDSPPSIHKYVEVDFPHLTSPKAQRIARHHKLSQYLSPISYSIAQGGTELSSSLFDLIPLDLRPASSSSKSIPSTLSAELLPHLDPSQPTLFLAECLFPYMPPEDSEAIVGWFGETFKDCVGVVYEMVGLDDSFGKVMRRNLAVRNLSIPGSVFPTPASQAGRFQVSQLGEGRFDDAGARTLWQVREQAIDPKELQRISKLEILDEIEELRLVLEHYVIAWGTKGAGMSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCA8</accession>
    <name>A0A1E3JCA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032177.1">
        <property type="nucleotide sequence ID" value="XM_019175687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCA8"/>
    <dbReference type="GeneID" id="30192772"/>
    <dbReference type="OrthoDB" id="2576009at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="21598" checksum="EEC5932946C414DD" modified="2017-01-18" version="1">MDTDSQLGHVLTAIQTSRPVLIKVARFLLSECRQRSAPGTAQSEVQSTTLSSLFKPSLAGKRKRSVTHFEGIPISAISAPSLPPSLSSSPTFTPTSSPADFRLHSKSNDNIQGRRVVSLKRAMGFYQSMSGLSVGEQGGSWCSDDSRGDDDYKFAYGCSNQEQKPQIVDDSEGDDDDDIETDSDDEDDVVLVFDRPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCL5</accession>
    <name>A0A1E3JCL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00730 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032297.1">
        <property type="nucleotide sequence ID" value="XM_019175807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCL5"/>
    <dbReference type="GeneID" id="30192892"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="499" mass="54541" checksum="D29CDF8D3AF37302" modified="2017-01-18" version="1">MSSPFPASANLQKPVCVFCGSSPGKLSLFTKAAQAVGEALARANVPLVYGGGRRGIMGVVSQSTLTAGGYVHGIVPNALVQRAAESTAAPSAEANAQSKEGSGEEIVKDETQEKLTTQVVSTMHERKLAMANLSTGGFIVLPGGYGTFEEALEMITWNQLGIHRLPVIILNIGGFYTNLYKQFESSVQAGFVAEENLALLKLVELEGGAEGEDGRAEEWGAAALKALEEWNLDSNAGLKLDWSNKSTPKINVSSPTYVFSTLRYTSEQHAGSIPLLETHLERLREAFTHFSTLEPAKWGTWPGDETLVTALNTALKQKDEQGPHDFRVRWVVYPGGKVEVQMPPAPKDSGNLDIPTEKSPQLRPVVLDPQVTHIARENQPEKDYRLYKTDQREMYDAAYVRGGQSSTEHPEVIVHNGTHLLETTTSNIAILRSTEQRWITPRIGSSTPLLNGVLRRYLLEKGAIEEGELTLQDLDMVKKGQARLIGFNGLRGIWEGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JER9</accession>
    <name>A0A1E3JER9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032263.1">
        <property type="nucleotide sequence ID" value="XM_019175773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JER9"/>
    <dbReference type="GeneID" id="30192858"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="39861" checksum="0D40C82FAEF61397" modified="2017-01-18" version="1">MPSQPPKNIAIVGGGIAGVSTAYFLATHPLRNSSTRITLIEGTKIAAAASGFSGGFLAKDWHGSATSSLSAMSWDLHAKLAEDFGGKEKWGYRTVETLSIETDATSKSRKPSPLPWLPKGLVHSARPMGSHSTTAQVTPGLFTQFFSEQFLAQPETSLVMGTVQSLTTDPKSNTPKSLVIVSPDGDKSELEADLVVIAAGPWTGRLAEQLLGEKVGGRLGVQGSRAHSIILKTKEELSATCLFTSMTMEDGSMGEPEVYARPDGTTYICGGGDDEPLPSSPADISPSRSAISKLHKQSQALSPIFTPEQGVEIVSEQACYLPIADRGRPLVGKVRGVEGVFVGSGLSCWGITQGPGTGKVLAELILEGEAKSADISKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEZ0</accession>
    <name>A0A1E3JEZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">L198_03249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032484.1">
        <property type="nucleotide sequence ID" value="XM_019175381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEZ0"/>
    <dbReference type="GeneID" id="30192462"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10543" checksum="A900134090A7D95C" modified="2017-01-18" version="1">MDTVVSSTISEPLDLVKLALGERVLIKLRGDRIVTGVLHAHDPHMNVVVSQAEESIYIVDVTEDGQPLPPRLEKRNFEMLFVRGDGVILLSPVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFF3</accession>
    <name>A0A1E3JFF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032641.1">
        <property type="nucleotide sequence ID" value="XM_019175538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFF3"/>
    <dbReference type="GeneID" id="30192621"/>
    <dbReference type="OrthoDB" id="2575053at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="435" mass="46743" checksum="BBDA0FD9CF1476DB" modified="2017-01-18" version="1">MSPTFPKPTPTPLASSFPNLKRSTFVTVSVIANDTSTSAPSSDSSSGFPVAIAIPALVGGMALAIGVFSFWWWWTKRSKRVKRERWEAAQRRKNKRRLAAEKASPRPSTSTSRKNPGGPKSPASEKSSKDKSTALSPPPSAAQRNFPNGAQAAYGAYAAQQAYGNGNEGWQTQPGIEQQQQYGYSYDQYGQPMPLSPVGQQSISQQQQYEGSYAPVQQTAPISKSVSSDTTAPLASQGAPVATSPTSPTSSKKESSVPSPKRSKSEEKQSSSQSRKGSRAVARMAVADNAAAAASVDPMYRHKPSKPSPLAIKAQQEREAAVAQRVLDDQNPFYAEPDELTPVDSRANAAWGEWGVALGTPTEGTPFSDSQAAVLEDNVYGNGNQTQSGLYTQDPYALYHDDDEDEQENRFHDAAASYGLGGGNKEKKRDMGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHE1</accession>
    <name>A0A1E3JHE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032603.1">
        <property type="nucleotide sequence ID" value="XM_019175500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHE1"/>
    <dbReference type="GeneID" id="30192583"/>
    <dbReference type="OrthoDB" id="2573153at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="397" mass="44367" checksum="B8C9BB5B23A5D6D7" modified="2017-01-18" version="1">MPEREYALARVSICRPRLIPAGTTTKDIEWESSDAHCTLSATPWPDGSLLHFDIKASSTPLVCCNFLPLVALPSRAVRRITFMETQAAFRYDRPAGSPQPPGTIVFNQPADLTALLEGLEPFFLISSSIKPVIPSVQAVQPGTLAPDSAPTSPYMIKKEPVSEPEESALDYHSWIKREPVLEWEESTPQSYSRVKREPEAKCKSKELDEEEVSSNVTKENLSPPISPNDAQSDYVPPSHSAVLPQAGSFEADERRELFIGGLNKEHTTAEILQVSLEQYGVVEESVLPDTSEGCQGGLAFVTFSTAESARKVILEHFVVDGVRLTVEYIIPYKVKGKTKKLRFSDFDWEMPTSTFVDYSETDQPGRKVRVEVPKEYKKRKASSYWLSIIMQTLPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI55</accession>
    <name>A0A1E3JI55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03435</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032668.1">
        <property type="nucleotide sequence ID" value="XM_019175565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI55"/>
    <dbReference type="GeneID" id="30192648"/>
    <dbReference type="OrthoDB" id="10664379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130373" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="172"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN99591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="34143" checksum="1DF33BB3CDD79B73" modified="2017-01-18" version="1">MRLSLLAAAPLIAAAAAAASLSYRADSAPACAQDCFDTADTQDSGCSSGDTACYCKNELVVSSIRSCLSSSCSTSNVTAAVAYGESVCAAAGASVSMGSSSTSSSGASSTSSSVSASTTSSSASSSDASSASSSPAVSSSTSNAPSSSASASSSSEKSSSSSQAGAVGGGAATQASSSAASSSSSTHSSSAVASSTSSAQVSSSSSAAQESSSQSSGVSTASASPSQSGAVAASSASPSSEASGLSSSGVSSSGVSSSGASSPGSSTASSNPSSSQTTSLTSSSQGAVVDGASSASDESSTATGSSSTPVSTSAQASSASSAASSAAQSSSAGSSGAGSSSSAASTFSSSSSSGAGNLMVNGPFMVAALVGGALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIG5</accession>
    <name>A0A1E3JIG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle checkpoint control protein RAD9A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032817.1">
        <property type="nucleotide sequence ID" value="XM_019175085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIG5"/>
    <dbReference type="GeneID" id="30192158"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="73058" checksum="63FC9026B4765C96" modified="2017-01-18" version="1">MEATLKDNGIRTFVKLLQCASKFGDDLHICVGPTCWEMSSIDPSKTAYVKYTLEKDFFQYWRRKSNVKGEIKCRVFVKSILAILGKPAQMASVQKIELKIVDPSAELRPRSRINKRRRREAQEVPADRDFIKKEGNEDEDTDTDENEAQAGLQAKLVIRLCCEHGVIRKHSLHLATSAFDRVNVDPETTPSHFTISSRILREWLEHFTISFPSSRDPLNPTGGLSQLCWLFAEDHVRIKSLEGGGGAGLSTEIKVDTQEFEDFELFGDRVDMRMPMKEFKAVLSLAEQLSITLNVSFSTADQPLTLTNLEDELEDLTIFCAVATSKEEEAFAGVHLAHEIEPPRAASREQSMNRGTARSAQVEVGGPAGSGASSARRKGAGTQRRPKLSLSASKPVEKEEERLVTVYLPSRAAASQSHSQVNPRASASPQKSRSNDQEPLFLPLSQDRSPPPDAGPSNTQFGGVRMTQQEVLDYAGLGDIDMDELGDMMNDEEEEEEAGASQIPAPSAHRQQPVTSPRAPMGSQARFKAREKERQERITQRETLGRVGPSRSLEQENVVDTTEANENDFTWDPTIDMDPNLMGELDAPAERPFASTSKDARRQALSDVEMEEERKPEISDNDGEVVDDWDDDGDDDEGALGPTQYDINSKYRPLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJC3</accession>
    <name>A0A1E3JJC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polycomb protein EED</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032928.1">
        <property type="nucleotide sequence ID" value="XM_019175196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJC3"/>
    <dbReference type="GeneID" id="30192275"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61221" checksum="EB28852098A4997F" modified="2017-01-18" version="1">MALDGPSEHANGEPCRKWYNAVHSTPPYQLETITHEGHNHPDELHRWDCAQFWPLVGALKPWRDPEGEVGWDWDEFEGTVALCGMNKLIIGQCTNEHAWSVLSDIQIGKEDTAKLYSVAWTYHPFTCHPLVAVGGKTGLICIIDVLTKEVLRVLKGHGDAVNYLTFAPHHPHILASSSADRTTRVWNILGADAPHNIPIEELSQNYPMADADEGTCVVAVIAGEGKGGHQSYVVHCEFHPSKRAIATCGMDYKVKIWALPPFPDPYPMSLPTPRGYRPKVLHFPIFSTSRLVAGFLDWVGWISDDILVVRSGKAVVTWQWLSYPRYFREDEFAALGTDPSYGDYSESGSFMTIARYDIGQEQWFRNIAHHRGFHPHPEDLSRFPPDKMVTETLIACASHVEEDFVAMSQNGEEKRVRNPGSIHMFNPCLAKEANGKPPEPYVTLRPRTPELFRSGHSRKYMVPEEDIEGDLDYDSGFTDNPSLSTWLLQPATMTEPADVDKWSRQNHEYVGLLNVAISPRGAKWVVGVGSGLSLFVWKIKDSDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLM9</accession>
    <name>A0A1E3JLM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033024.1">
        <property type="nucleotide sequence ID" value="XM_019175291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLM9"/>
    <dbReference type="GeneID" id="30192372"/>
    <dbReference type="OrthoDB" id="2563118at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130442" evidence="2">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16389" checksum="0E54E2E7CC262413" modified="2017-01-18" version="1">MLLIILIFWIIRLVILYSKRRKSNQAVEPAAQFRHVANYLFTSRHDTQPSLDDDVEQGFNPGAERGRSRRARDEAPVARLTSESQASLPAYGAASLPVPPGQIYSSGQVRITPDRTTVLLTGSLPGTTEAPPPEYTKDETPSTPRRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM66</accession>
    <name>A0A1E3JM66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033221.1">
        <property type="nucleotide sequence ID" value="XM_019174842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM66"/>
    <dbReference type="GeneID" id="30191913"/>
    <dbReference type="OrthoDB" id="2569217at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="693" mass="77446" checksum="E1B6D25A04CF4462" modified="2017-01-18" version="1">MTLHSNITRRPPVRIPFAHSRPSAPRCCHRPFSSSPSARQSIGDALINQDPYKRIWFIQPTSFMSFARDGGRTLHLSQIWPDSLYHEPYLIPFWAVTIFNDQMVEAIHRPTGYTNFNAPAQRLRSEIGATIAAVPADHWASGMYFGDHARQRTVIHHKILEDPFSRLAQYIPTNNPGSLVRPTNDAFDPFFKTDLYSPLYTPKFALGPPKMEQRDMDKVVESQKFVANAGWEDVFTRVQDSKVFAVPVYRLIYKVHLRDGSIAMCDGEIPGESHNFRVNWPQGRSQASDSTPKVIGRLGRLIWDEMDLHPPTWRLTTKGSTDVVSTIFDTMRRRGPMTQGMWEDGNIVPLIGPRGTASGEELIHYGDDFIKNRGISVPEPSYPVKVRNEPRRSSSLFSSPAATAEPSKPSSPRPSSSTTKPAPGTSSTTPSWSSSSLKDKRDTRFSAYAQKQAERIKGSIGAVAKGRTARRLTPHDQRGYYAELGLEVSADFLDASKAADVDKLVKDKFNGLSFVRHPDHGGTDEGFHNLVLSRDHVESCTSNFLLLLNKALTKHIDQKRLFYNKQVLSCPELSSSQSKTPPPPPPPPPPPPTPPRKPPSWSPSPPYNASGSPSDKHGHYATLGLSKQLCREFLDVGAEARVNEFILYRYDTLREAVPPGDAKKLRKLSEAFDSVKNCMSLKRLGFIIIELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMF1</accession>
    <name>A0A1E3JMF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bud emergence protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033290.1">
        <property type="nucleotide sequence ID" value="XM_019174911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMF1"/>
    <dbReference type="GeneID" id="30191982"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="323"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO02038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="684" mass="74545" checksum="15640D62D2C2A0CF" modified="2017-01-18" version="1">MKSLRRSLNHEKSNGSPQPSPPLPTSQSATPHVLGRPSEKVAPPQKVIKALASHQSTNPSELSYNKGDFWYVTGERGSWYEALNPLTGSRGAVPKQDFEEFVKGGKHPAGAKSIDVGSSRPNTPSHLQNSLQNNPRSPGPGMVSPPMSADSARSSKSPVYAIVQYDFQAERPDELEAKKGEPIVIMAQSNHEWFVAKPIGRLGGPGLIPVAFVEVRDPKTGQPVSIEPNSIPMVEEWKKKTADYKAAAIPLGKFDIGPGVTNSPYAPNPGSANESQTSLSRTGSTSATLVNPVTGSASTSTTPAPTERSSRRASYVPVKNEMLPPGNLTSMSVLSFHQENGVYWFRLNVNFVPDDPTASAYSFGLYRSYEDFYDFQIALLDTFPYEAGRPGSGNGRETPERILPYMPGPVDYEIDDELTEYRREELDVYVKELLDLKSKGAGPVVRHELFRTFFATRHGDHYEKISREDAVEELQEQLADVQLDPRLSGGYSPSAIRSQSAASRHSQTYNQYRHSPQAYQGHAASRSVSSRGASPLPQVETHERSDSYGRPTSGRQSGAAHYVSGGPSTGGTASSWGINNGPLSASTVPTAPGTAPQQAGPPPYIKIKIYDRATDDLIAIRVHSAVTYADLFEKVRARLGPGVSVLRYRVSMNGQEGYRELRDDAELSGWLRTEGQKLVLYAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG2</accession>
    <name>A0A1E3JMG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033098.1">
        <property type="nucleotide sequence ID" value="XM_019174719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG2"/>
    <dbReference type="GeneID" id="30191786"/>
    <dbReference type="OrthoDB" id="10311692at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="169" mass="19545" checksum="6C2A3441B0723359" modified="2017-01-18" version="1">MFNRPWSPPHSTGLPSSPPYDSDPQLSAANWKSPYYPTMNPAGELPFFFIDGIKIYELRSLDAYTFQRWARSIKTLLLMKGLLPILQQDEIFISPTTSTEWVKRDREVFAYLRNAVAFEVEKALSSDTVDYSEPSMEHAHSRAKRFWDLIEEEVYKRNRAGGVGGRPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG3</accession>
    <name>A0A1E3JMG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033302.1">
        <property type="nucleotide sequence ID" value="XM_019174923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG3"/>
    <dbReference type="GeneID" id="30191994"/>
    <dbReference type="OrthoDB" id="2576404at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="57963" checksum="740B16787C29DD8A" modified="2017-01-18" version="1">MPFYTTFEPSFDYAFPAQPRYTYSPFYAEPTHHYPFHTRTPTPTRQPVYESDSGLDDEEQAVLAQLAAIRQKREQLKATQAREAARAAKAKAQREAMIKAELAQALVREQEKKRKQEEDRKREEEKERRAIFSRAMELANVQREKEGLVQAEGRKRQQNGAIKSDSPSHADINNILSALFGINLAPSDEEEEGESEHEDAEVSVPILSPQCTSAACCKSEKPTNTDNEAVVKSQLAQAIARKEEIEQEQERKRKQDEEKQEEERKQQDDVRRRASSQAMEKKAQREKERLARAQAKNRQPAHNEDLQNLLKAFFGVNPPTSDDSEQSDVEFEASEAPRPQRRAAPVKSTNAPAPKAPAAPQPEATASTAAPEPSETLSPAFTILRDMDTQLSQLKSSFTFPSHLSFAHSTPNGQTPPLLFNRTNAPYHAQTNALLQLLLHADTVISEGQPEVRKARKEMVKKVEAEIRKMEEKRDEIWEEVRIRRESGEEAEPDEDEERSWSDCSSVVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMH1</accession>
    <name>A0A1E3JMH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02791</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033312.1">
        <property type="nucleotide sequence ID" value="XM_019174933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMH1"/>
    <dbReference type="GeneID" id="30192004"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="547" mass="59699" checksum="A20164C67FE5C9A6" modified="2017-01-18" version="1">MPMVVMTPDTGPERQTGRKAQTANIVAAKTVADVIRTCLGPKSMLKMILDPMGGILLTNDGHAILREIDVAHPAAKSMIELSRTQDEEVGDGTTSVIILAGEILAYSLPLLERHIHPVVIIRAFKSALSDALDTIQRVSVPVDITSEQQMLALIKTSIGTKFSSRWSDLMCQLALEAVRTVAGGDQVNIKTVDLKRYARVEKVPGGEIEESRVLSGVMINKDVTHPKMRRRIQNPRVVLLDCPLEYKKGESQTNIELSKEEDWNRVLQIEEEQIKAMCDKIVEFKPDLVFTEKGVSADLAQHYLLKHDITALRRVRKSDNNRIARAVGATIVNRVEDLRETDVGTQCGLFHIEKLGDEYFAFLDECSNPKACTILLRGPSKDILNEIDRNLADAMSVARNVVFNPILSPGGGATEMAISVDLGEKAKVLPGPQGAAYKAIADALEVIPRTLVQNCGGNAIRTLTELRAKHAEGHNMFGVDGDTGKVVDMQTYGLLESASVKIQTLKTAIESATLLLRVDDIVSARRPGEEGGGVQTMGEAAPEGMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JNU1</accession>
    <name>A0A1E3JNU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">L198_02522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033049.1">
        <property type="nucleotide sequence ID" value="XM_019174670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JNU1"/>
    <dbReference type="GeneID" id="30191735"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO01797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="29230" checksum="E7E88581E85E38B6" modified="2017-01-18" version="1">MSGNSELDYLKSLVSQLQGKIESLEKSTSNSLSSTLDSAKSALSGAGAAPNPPRMVLIGPPGAGKGTQAPNISSKYCICHLATGDMLREQVAKQTDLGKAAKKIMDQGGLVSDEIMVGMIKQELTNNTECKNGFILDGFPRTVPQASKLDAMLAESKQAIDHAVELKIPDALLISRITGRLIHPASGRSYHREFNPPKKSMTDDQTGEPLIQRSDDNVETLKKRLSTYHQQTGPVVEYYKGTGVWTPVDAAQSPKLVWASVSKILETPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPS8</accession>
    <name>A0A1E3JPS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucoronosyl and UDP-glucosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033164.1">
        <property type="nucleotide sequence ID" value="XM_019174785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPS8"/>
    <dbReference type="GeneID" id="30191854"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47310" checksum="159E2715A7417964" modified="2017-01-18" version="1">MPSKKAKILFLTAQHGQANVHLAVIAALQSGLPLPLAPDLSNIELDLHLASFPHLAKRVPTGVTWWEIEGKGFAQRFEEEFGKAEGDRRAFDLLSYSTGFLSSLYAYTQILPVVHPETPSQYLTSCLSLENILTTLSPDLVVVDQLFAVARDVLGKGDWKWIRLSPNTIKEVAVVEQGLGIFRWPALCTGLPYPVPYSLLPLNIISTLFPLFHNPLNPLLRAFNTARHSAGYKGQFPLLHPGEPTGRHSRVICMSTPGSEIDAVYPGKDKVVCAGPILLPVRPLAEADPELLEWLGPSQLVLINLGTHFLQTSSFANAILHSILTLLTLRPDLKVLWKLCKYGEYDIDLSLLGDVLGKRVRVVEWLDAEPGSILHTGKVACFVNHGGSNSYHDGLAAGVPQIILSAWFDCHDFSTRVEHLGNGVWGNKHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRM2</accession>
    <name>A0A1E3JRM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033580.1">
        <property type="nucleotide sequence ID" value="XM_019174528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRM2"/>
    <dbReference type="GeneID" id="30191590"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000238">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="79495" checksum="CB2BB6A3A11AF2F7" modified="2017-01-18" version="1">MVCRDVAVMRRRSDSYLNATQILKVAGFDKPQRTRVLEREVQKGEHEKVQGGYGKYQGTWIPIERGLALAKQYGVEDLLRPIIDYVPTSVSPPPAPKHTVAPPSKARAPKERPTKSTPLRTGPQSAAALQAQAQLSRQAKHESTPDADASFRSYETRTSLTPEDDSSSDTPSPVATELSDDDMDVDQPKPGMLPNVTMSSTMDDVGSRKRSAAMMMEDEDHYARLREIRGSSAVHTPQGTPRHIGMGMPEEPLGPEQYTDIILNYFVSETSQIPQILISPPTDFDPNAPIDDDGHTALHWACAMGRVRVVKLLLTAGASIFAGNNAEQTPLMRSVMFSNNYDMRKFPELYELLHRSTLNIDKQNRTVFHHIANLALTKGKTHAAKYYMETILARLSDYPQELADVINFQDEEGETALTIAARARSRRLVKALLDHGANPKIKNRDMRSAEDYILEDERFRSSPVPAANGGSAKPGAADGDEKPLFAPQLYFSEAARICGGSGLADISSHMSSLSRSFDAELQGKERDILQAKALLTNIHTEVNESTRLISTISTQAAPLDEKRRELESLQFQVKDKVKAALKKGYVGWLEGELIREKRWEDGELNSGSEEEERKEVESLRDIPAGGEEVVQAEEEKLRWEIEEKRKRRATLVERFVKAQTEAGTSEQIAKYKRLISIGLGGVSANELDGLVNQLLDGLEDEGDNYASGSRPPQAPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRV9</accession>
    <name>A0A1E3JRV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class III aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033651.1">
        <property type="nucleotide sequence ID" value="XM_019174599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRV9"/>
    <dbReference type="GeneID" id="30191663"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="460" mass="49138" checksum="9C134FE8E05802F6" modified="2017-01-18" version="1">MAPIAVSESTTVVPSPIKSAPVSSQFHHAQPQPIAASASGIYFTLSSGQTVLDACSGGAAVACLGNGNMEVVGAMTKQAEKMAYAYHQSLGTEEGEKLSKWLCDRSEGALVAAAFLNSVGSEAMEAAIKTARQYWVEAGQPERKYIIARFPSYHGNTLGVLAVGNVPGRRDIYTPLFSSSAFHHVSSPIYKRYTEKGETEEAYSARLADELETKIFELGPENVIGFVAEPVVGAALGVMPPPKGYFPAIDKVIKKHDLLLVMDEVMCGSGRVGQLFAHQAVGEGVKPDIMGMAKGLGGGYVSISAVLVNERVASKVREGGQWKNSHTYQNHPVNCAVAGKVMEIVEREGLLENVRERGQQIVEELEVAAKNIPAIIDVRGKGLFIGVELDGPMTLKPRLASRVKDQAFKNGLIVMGLSGTIDGSEGESIVLGPAYTITKEQASEIVRLLVKSIKEVVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD3</accession>
    <name>A0A1E3JWD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033810.1">
        <property type="nucleotide sequence ID" value="XM_019174003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD3"/>
    <dbReference type="GeneID" id="30191056"/>
    <dbReference type="OrthoDB" id="10622120at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="16927" checksum="E04B9DEF99880972" modified="2017-01-18" version="1">MSIHPALSLQDDASAMMPPAQQSSASTGPLRASQLLDMMGPESDGVSPATLEYVKPPQRRGRPAYQFEPPPMAAVEPSSSLDSDDDSHPLSRNDLESFSVASDTTSSLAKATSSVPALARQRENHHVELPGRYLKESAKSEAANFDGLFDSVLNGDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWR8</accession>
    <name>A0A1E3JWR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033966.1">
        <property type="nucleotide sequence ID" value="XM_019174159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWR8"/>
    <dbReference type="GeneID" id="30191216"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130641" evidence="6">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="395" mass="43246" checksum="C06287D9F85A226E" modified="2017-01-18" version="1">MYPSLALPALLLTAVGALAHGSHGHSHEQLDPWNEEFANTPDLSFSGVTSFAHLPHQKCLDNKNAAFDVALLGVPFDSAVSFRPGARFGPYALRSGSRRQRPERGYSSRLEVNPYTHGLYMLDCGDVPVTPFDPATAIKQVNSAYRSVLHHPVISEERMEELNMKKGLDGKFHPRIVALGGDHTIVLPILDAVHEVYGPVSVIHFDAHIDTWNPHRYLGSVSLQADLNHGTFFWHAYEQGFIKPNASIHAGIRTRFSGPEDLDDDITAGFDLIHTFDIDDHGVDWISEKIKARIGNGPVVISLDVDVMDPSYVPATGTPESGGWTSRELRRILHSLVGLNIVAFDIVELSPAYDTNAEISAIAAADMVYDFLSILALGVDGEKKAGDEGRVTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWS1</accession>
    <name>A0A1E3JWS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor ISY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033841.1">
        <property type="nucleotide sequence ID" value="XM_019174034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWS1"/>
    <dbReference type="GeneID" id="30191088"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="35980" checksum="ECEA87FD3B857BB3" modified="2017-01-18" version="1">MARNSEKAQSMLYRFREQQAIDMGLGTRQKGDRRPRMTSTCTNLREAERWRGDIMRDIGRKVSKIQDVSLTDYQVRDLNDEINQLFREKRNWENQIINLGGANYKRSAGVMVDDDGREVPGTRGYKYFGRAKELPGVKELFTRSAAQATEESARNSSFQMFRHQGPGYYGDEDELEEGLLAEEEEASRQEWNDQARETAELLGITDETSLPAYPVELPSTSGESEKAPPATKGKKTAANGKSKRKAGIEEEGEAKKSKGDEVSEEGQNVPAVQDAVAQAAAAGYLGVLDADSIKFPTLPDKEEMAKVLLEVRKQALRDEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX01</accession>
    <name>A0A1E3JX01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034034.1">
        <property type="nucleotide sequence ID" value="XM_019174227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX01"/>
    <dbReference type="GeneID" id="30191285"/>
    <dbReference type="OrthoDB" id="2563749at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="661" mass="72217" checksum="C200E846C7148DBD" modified="2017-01-18" version="1">MDAHEPLHLAQAVNDMPFMDEDLSDTQHFFQSPPPEDEADAHHQQQQHDLPEVPGSGLDENRPLTQEEINAAIKQSILKAPEHVRDEMNHENNLGDGSELVTSSGIEADAQHHEPTPTLNSSIPTGHDSNDVSVSGPSGLDPLGSEHNPIYNPTVYMAPFSKPERSQEDTPQPAYYVFDNRQAFNAWLDGEGSWCHFVQRRSTTPDKRSQERLQTRIAKHNKKLEGMSEEERKLALPLKTRRRNRVSPVAEKVTFTCHHAGTYNSQHSSNLPKEKLRMNTKKSVKCACPSRIVLSEMQAGDCRVCYHWKHEGHDPFTEGDLDGGRMNKAIDEWMVARINEGKTPEEIRRLLDMDEDAKKAYLDKVAADPSQIDPNLPPPVALVRETKFRYSEIYNRFRKLKGPIKETKHQKAATASGSKKAGKGKRKAGDLDAIPSPTPTSDGPELLGDSSKRARVDGPDPNMFIDPSLQSPNSLARAEAAAEHTQTDALDAISHAANAVADTDHHHHLHHIPSLDEHGHEHGHSHGEGDNEDEYASLAAPHESLARALLSLPGAGNSSNHPSTMGTAATAAGNDNPDGNLHSTGAGTGIGVDLGHGPALGHGHDAHHHGQAQGQKDEDLEAMTLEEAMSFEEAMRRLAGEVAGVGEEGEGEGGMEMGMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX59</accession>
    <name>A0A1E3JX59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034075.1">
        <property type="nucleotide sequence ID" value="XM_019174268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX59"/>
    <dbReference type="GeneID" id="30191326"/>
    <dbReference type="OrthoDB" id="10344420at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30151" checksum="59C4BB0050C30B8F" modified="2017-01-18" version="1">MPQPNSSTRARVGSPPLSSPNSPQSSNRTLVRGSARTYTPEDTPSLSDAYLTASSHIDLPASSQREGAGSPSRTRTTGTTMAAHPTGSGFHIWHKPAVGRPRVSTSSSDESIKGNPFAFHHPVHQQPVYQQSHPPPVFQTQTRPSHATFRKTFTRILGRLAVPHSVSISFRPPEEFEQYVQDVMGSFLHTFDDYTTQEAQEGIALMAGQLEAWQGVLATPAPYLMSYMKGEEGERKEGERHEPLAGLIEKSWMELDGFVLVEGYPREVPRPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZJ2</accession>
    <name>A0A1E3JZJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01427</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034295.1">
        <property type="nucleotide sequence ID" value="XM_019173590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZJ2"/>
    <dbReference type="GeneID" id="30190640"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="304"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO06195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="745" mass="79709" checksum="5384E1F2B77BEA7A" modified="2017-01-18" version="1">MSGQQPPNFNPGAFEFRPGQQQSFVPRQQQQYQQYPQQGYPQYGQQQQQPYGAYPQYGGYPQQGGYPQQAQGGYPAPSAPAPRAYQPPNRTVQGFQPPTIPSSSTQNGPPKAAPSLSIGGGAPKAAPSLSIGGGAPKAAPSLSIGGAAPKAAPSLSIGGGAPKNAPSVSIGGAKAAPSLSIGGAKKEEIKEETPDSALTAAQSSPKPAVSDKAEAAPAAEKPVQTATPPVATDAQTKVVAEAPAPAKSGASTPTPAAAAASSATNYSKVSAKNDAEAIIKEQNAAGADAMRDLYGDDQKDPNIKSHLNIIFTGHVDAGKSTMGGQLLYLTGAVDKRTMEKLEQEAKAAGRETWYLSWALDNGKEERAKGKTVEVGRAYFESDKRRYTILDAPGHKTYVPHMISGAAQADVALLVLSARKGEFETGFERDGQTREHAMLIKNNGINKLIVVVNKMDDSTVQWDQGRYDEVTSKITPFLKAVGFNPKTDITFIPVSAQVGQNMKDRVDPKLAPWYEGPALLEHLDNMTIMDRDIDAPFMLPISEKYNELGTMVMGKIESGRVKKGDTLLMMPNKHTVEVAGIFSEQADEMDMAFCGDNIRIRISGVADKDITPGFVLTSVQKPIKTATAFRADISVIDTKNIICPGYSCVLHVHTLAEEVTVTQFLHYYEKKTRRKSKKPPQFAKSGMLISAIIETTAPVCIEKFEDYKMLGRFTLRDEGKTVAIGKVTKLMKSEDVPDIAGLAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZP0</accession>
    <name>A0A1E3JZP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034381.1">
        <property type="nucleotide sequence ID" value="XM_019173676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZP0"/>
    <dbReference type="GeneID" id="30190726"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="109" mass="11323" checksum="681DFE8484DD0717" modified="2017-01-18" version="1">MPAVNNNLPESAQPSPFLSGGVPPPSSPASHCSVDLPLVACLDDLDGHLAKKQKNPERPAEEVTRLCDAVIALLAHLNNQGQTLLAADGADECGGVRRQSTNYGLISLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZQ9</accession>
    <name>A0A1E3JZQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034478.1">
        <property type="nucleotide sequence ID" value="XM_019173773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZQ9"/>
    <dbReference type="GeneID" id="30190823"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="309" mass="33853" checksum="D50C47AED9934D34" modified="2017-01-18" version="1">MGSDNPCTLTLEDGTHYDLNQLSSSTADYTAQVGDTSYYLNVCKSVVGELYKIDNPDDVGGFVRRPDGDFSLGQVNTNLTLSPMVNDPLLTMTGGSACPGNPSETASTAIRFICSPSDFDAGKPLLVASLPPQDPCHFYFEWSTHVACPTNPKRELESHHYYIAFFAILAIAFLTWFGGVTMYNRLKLKRRGIDQFPLPDFSSWHLPSIHIPSRSNANSSSNGASRPGWGSWNRRSSGYSNVRADEHDDEETGFAGRFSLEESDEDAEDLTTVGVGEANVWRNHQQERDSTDGQGKGKGRAEHGGLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K050</accession>
    <name>A0A1E3K050_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034539.1">
        <property type="nucleotide sequence ID" value="XM_019173834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K050"/>
    <dbReference type="GeneID" id="30190884"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="752" mass="80341" checksum="7634FE9E4AD42242" modified="2017-01-18" version="1">MADATKYGNAADFDVELHSIYAAYIGLFESSNVDWWDKSWGGYFVSFNDFLGFGWEVMGMFSLLLLIVDGVTGKPHIAVRREQIALFARMIRTRQVHSQIIFGENLPKDPPTTLPLTPVPTRNLALRRLVNIRDLSAYRKLAATLPAAELSYLRSRVRSGEPAVIEQLFYAGGSSGERDTGGVGVRDNGVGYTFACVKTNWWEKGGAPYGVVPGQGKTQPGKGPQGKGLVLEVGMAVLRCANLRAVGVWPPTPEDNYRKSHYVVDEWRTNHSPPTFPRAYAFGRSEYVAEKKIETILDATLNALASQETDGHANTLILLTIGDGTPLPLPNSSTLPANILVFDLLALEFNLLRRAQAQGIPGAPDRHQPLSSLVSLLQTLQIPVTPYAPLGNAGNDAYYTLLAFQKLVMGETRLPDMLFKQPGPYSAMPFPAGAGNRMSMAMPFAPVMNMPLPVMPAAGHVRRESNSSRASLRTPASEYGSYPPSPAEEQKRRRMTSDVAKRRPSSTGDALGAYSFNNRSQSQQRSLGGSSQNLAALGSGRNRQSMVRSQTVFWDDAQYAPPSADNQGSSLKAPQAPLHGESTGASSNSSENRGRPKDGPPVSRSAGSSVRLAAGRGVSFDGTGGDTNAPGRGSAGNSPVNGTMRPPSYVAGNGSAASVKPSGLSSTNLKKHDAGRTDSSGTISTGITKPSSNSNSSGDMVIMPTKVRHSTGAGQVVNDEKANATADVKGDKEKKPKKSKNIAGAFAKFWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2M3</accession>
    <name>A0A1E3K2M3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034710.1">
        <property type="nucleotide sequence ID" value="XM_019172984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2M3"/>
    <dbReference type="GeneID" id="30190025"/>
    <dbReference type="OrthoDB" id="2595509at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="301" mass="31839" checksum="DA50493FFEC015DF" modified="2017-01-18" version="1">MDRVNKWKREWVAPEGLPAESSYKVFKWVKSDVKAQFGNDAVYEVRDDTPGQDDDEGDEGEGQENEDDEDDEDGDNGQNGEESRDPAKGEVQAAQGGAETTGVQDDTSAQPEGEGDAPEAPKETESEALPETLSTAAEAVAEPQAALAPAPAPEPAPVPAADPQSITEPTAEPTHEAPIPPHHEIPSNAVEITNSIPGDSAQLGQGDLGLQGGVVAERSHEEDGDVEMEGVKEAAVEEEAVQESGDQMEVDQPATLVEEKGETPVEKDEGLVMGEIEPPVPEIAVEGEDKPTEVEKEAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3F1</accession>
    <name>A0A1E3K3F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035036.1">
        <property type="nucleotide sequence ID" value="XM_019173310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3F1"/>
    <dbReference type="GeneID" id="30190351"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="462" mass="51226" checksum="8FC778FF0BDC9F55" modified="2017-01-18" version="1">MLAPQITTQCSRTALRSASQRAPKLAWGQSSLRYQSSTSSPAPPSAPSTTPKTSDAKAEFRHNELAKIIRDTVKSTGPIPISQYMQFCLSHPTYGYYSKGDVFGQKGDFITSPEISQIFGELVAIWFLTRWMDKGSPSRVRIVELGPGRGTLMDDIIRTLSNFPGVASSVKSIHLVENSLAMREVQRKKLEPRIEGKDIALNWYTGINEIPETEDAYTFFVAHEFFDAMPINTFEKTDMGWREVQVTHDPSFDPEISTPSAPSGLRFALSSSPTPLSTILPETSPRFSKLLSGSRVEVSQDSYKIMRQLGEIVNQGKGGCGLVIDYGADKAFYNSFRAFRKHEIVDVFQDPGNCDLTANVDFAYLGESLSNLSTPLGPMSQASFLQSLGFHPRLAKLVEAAPEERREEIEKGAKRLVDLLGMGTQYQVMGVVSGVEELKEGIYPFSLKKEEEKQVASRVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5N6</accession>
    <name>A0A1E3K5N6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035019.1">
        <property type="nucleotide sequence ID" value="XM_019173293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5N6"/>
    <dbReference type="GeneID" id="30190334"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="397" mass="43436" checksum="AAA59674E55E4895" modified="2017-01-18" version="1">MVIPSLLFQHLPLRGLKSLPRSPRAWSQHIRNVHSLRDLPRPTEAQLARKPRLVPFEPPEAESSAMAEARFTPPSHQTSKWTSQPDTVLLIQKKDDPRTTAAMGEMLHFIRDNYPHLRLIVEPHTAHDHPSFDNLIVASQEEQPLLPLHTSLVVTLGGDGTILHVSNLFSQGECPPVLSFSMGSLGFLLPFHIDSLASALGNTLTGPVSLLNRMRLACKPLDVEGNLLSRLGENGWQVMNEVALHRGRHAHLTVVDTYFDRQHLTEAVADGILLSTPTGSTAYSLSAGGPISHPETDAFLLTPIAPRSLSFRTVILPGRGEVKLEISPLARAAAELSIDGRDVCNLTSKESVVITKSPFPIPCVERSGGESGWVKDINSLLQFNVGFRNKSVMGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K695</accession>
    <name>A0A1E3K695_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035455.1">
        <property type="nucleotide sequence ID" value="XM_019172513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K695"/>
    <dbReference type="GeneID" id="30189544"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20179" checksum="205C7E65B1C3D545" modified="2017-01-18" version="1">MVIDLIIIASQVRDEFSDFRESTIAAFLTQSVKLDENSTIKFEIWDTAGQERYKSLAPIYFRNSNAAVIVYDITQTSFEKAKQWVKELKRSADPSIVIMLVGNKIDMASQRKTPRELGQQFADEEGLLFTEASAKTGEEVEELFHAIAKKLPLAPPQQRSQSSSKGVNVSGQEATPQACTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K697</accession>
    <name>A0A1E3K697_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional adapter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035559.1">
        <property type="nucleotide sequence ID" value="XM_019172617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K697"/>
    <dbReference type="GeneID" id="30189650"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="624" mass="69295" checksum="4FD33575B9FB95E4" modified="2017-01-18" version="1">MTRSIPKPLIPLLNPTSYPSLPPLADLETIRSALLDYSSLIPSSSQSQAQSQAGIEELRKSKKRKEREDEERAESERLAKENGEREREREGERERERVEALERSKMMGQQGGKKKGLMGVGGKGSPGVKVKRERTSLSPAPSNASTSSFKPPMSQPHTYASSQTKKKKIKRVIDSDDETPSIPLSQTQSHSGSNRPVQPSPPKTTPTTSALKLKLSHPQAKRPVDYSPTPAPPTGPGAHIDFSLPPAPSRPLIPHRSGPREAPKPGPKKQSEVDDDYSNKKAPNQVAFPTFWSFVEPYLRDVREDDLAMLGFKTDPPEAYQVPNRGRHYTEVWDEEDGNPPGTRTRMGVPNLRQQQLAQMRKAGGLNQPHFVPSAEMRDENLVDEQRGLGALTERVVAAVVGTAVDREKERERQRREKEDGGVEDSGLEPARVDVLDLEERMKKELRAVMLLGEHEDFDPNNRDDDEVSSALRQCQRLLAHQTSLNDARKARLVELSKQRLAYTEYRAALDGIEKSIEEAWAKRIKKYGLSPKKHPHPPTVEGSYGTIIGEHGEVVHLNASGRPPVPDSVKRLVETRKGWIGSVGQVIKERPRGEMVGIPGSSVFEGVGTDRNDDAKETSQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6B9</accession>
    <name>A0A1E3K6B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acylpyruvate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035545.1">
        <property type="nucleotide sequence ID" value="XM_019172603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6B9"/>
    <dbReference type="GeneID" id="30189636"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="228" mass="24552" checksum="CA8B2F4364E7797B" modified="2017-01-18" version="1">MSNFVKTGRKIVAIGRNYADHAKELGNAVPKEPFFFLKPTSSYLVAGSGPVEIPHNVKMHHEVELGVVIGKDGRDIPASAALDHIAGYTLALDMTARNIQDKVKSKGLPWSTAKGFDTFTPVGPFIPKHFLPDLAQVGLHFTVNGTVKQSGITADMIFDIPHLISFVSSIMRLEEGDLLLTGTPKGVGQIVGGETFAAKLTYPGVDGEVISEYEGQAVDRVGGYQFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7N1</accession>
    <name>A0A1E3K7N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035718.1">
        <property type="nucleotide sequence ID" value="XM_019172776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7N1"/>
    <dbReference type="GeneID" id="30189810"/>
    <dbReference type="OrthoDB" id="2563893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="170" mass="18886" checksum="E3F36438AFB2D264" modified="2017-01-18" version="1">MSAQPQQLLTSSSQLPTSPAHQQPQPVPKTATKQKKQLRGPAGNMELFEWQATMHTCQAINVDGERCGNSITNPRQNRFCPNGWHFENARYDNVVEMVERRKAADEANAIRRKAEIAEQLALFEAQFTLTSNADKASSSGSLQSPQVVTSALPQQRQSGFSTTFRRGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9T2</accession>
    <name>A0A1E3H9T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000071">
        <property type="protein sequence ID" value="ODN73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027749.1">
        <property type="nucleotide sequence ID" value="XM_019180268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3H9T2"/>
    <dbReference type="GeneID" id="30197513"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="100" mass="10343" checksum="A324F84B060E8413" modified="2017-01-18" version="1">MSGDDAELTKSLNHLGGKDVQDTEALRTRDDGHHRVLSSSSTPGSVAAGSAGADRLTEVTRDVVSSPPTDRTPDALPSSIHPDFSSPTTTLASMPTEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLR8</accession>
    <name>A0A1E3HLR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028004.1">
        <property type="nucleotide sequence ID" value="XM_019180005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLR8"/>
    <dbReference type="GeneID" id="30197243"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN77297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="452" mass="50441" checksum="79C51D00715D4466" modified="2017-01-18" version="1">MDEEYDVIVLGTGLTECILSGLLSVDGQKVLHIDRNDYYGGDSASLNLTQLYQKFRNSPPPESLQLGRDRDYAVDLIPKFILSSGALTQMLVHTDVTRYLEFKVIAGSYVYRDGKISKVPSTEMEAVKSPLMGLFEKRRARNFFQFIQNWKEDDPATHQGLDINTVPMKDVYYKFGLEAGTQDFVGHAMALWLDEEYITKPARETIDRIILYTASMARYGKSPYIYPLYGLGELPQAFARLSAIYGGTYMLQKPISDIKLSSDGKFEGVTSEGETVRAKKVIGDPSYFGAGKEDGEGGRMRVVETGKVVRAICILKHPIPGTDASDSCQIIIPQKQVGRRNDIYIASMSGAHNVAPKDVYIAIVSTIVETSVPEREILPGLQLLGNVLDKFISITPLYAPTSSGQDDNIFITKSYDATSHFETVVEDVYDVWRRYKGGEELVLKKRDVEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRU8</accession>
    <name>A0A1E3HRU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028107.1">
        <property type="nucleotide sequence ID" value="XM_019179931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRU8"/>
    <dbReference type="GeneID" id="30197169"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="490" mass="57786" checksum="F6A741B842917A5D" modified="2017-01-18" version="1">MSVSPPKTPPLHCDLTTLSPLPPEVISPIYAYYLAQNPLESRSQFLNLITLSKEIYSENAWRLYEAIELNDQNHKAFFDGLWNAEDVHVCQSQSPCSPFLRCETSTKEFAREMETYSHPKRELERPSHIPSDSDIPYPKYEYESYIPFHLHPAIRKVLLIRQCRRLCIDGWEVIDGLRMGNDSVQNVVTAWPRGHVVCNDEAFDYTWISDPLFFSVTHLSFGENVGSYCPPTQYKCFGPALKHVYLSFNDRFYDLEGEFVEAARFGILDRFEERLPRKRITKLLQERLSFALRSEVDEKTSLTLHNAWPDDIEPGLADTMIYELPRSMKNGDGDWKRQLAMTTWEMKDYMSELEERMKDDRFGVNVWRPTMKPWKIRFTNMAPIPPNTDIISAVLDDYPLGHDEHFDGLFRKWWEEVVSFEGPVKCDCCEIFNKKHPKINAYKYSYNTRWKHFKYIQERADKIREEYESRQSVEGAIHVSKFYLYDYSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV62</accession>
    <name>A0A1E3HV62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028150.1">
        <property type="nucleotide sequence ID" value="XM_019179846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV62"/>
    <dbReference type="GeneID" id="30197076"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129376" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN80055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="47507" checksum="0FC6A14B0528DD05" modified="2017-01-18" version="1">MLALFGILALLGGAAAWPDPFWIVMHGNAIFTSRLDPIVSPGAVAGHVHSVIGGTAFNPTYSYAHSTAAKSTTANVEVDLSNYWVPQMYRKSGDGFELVKMNRVNTSGDDEEVYPFPKDFRMLAGDASRNTYNESDYTNNAISYVCLGVDGSPQTNAFPEQSCPDDLRAQVFFPNCWDGVNTWLEGSKHVAYPTSGGYDQGGPCPATHPKRIMSLFYEFHFSVSTSFCDFTNGWPEGYFEEIFSYKSTCNVEFSLENCPPLAQYFLKDGAGTVVPDDDAVIVDEDVGVNGTILSALPGNNPVWGRSGPKSPDASYVETGKLVSFADGSEVATSAAVSGAASSSSSVVVSSSAATASGSGSISNTAPSSSSPSSDAFTTAASLSSSDNSPVASSTQTVSKAIATNVAAVIESSSVSLSSPSSDSGSTATGAGASSETGVAVHKTCARRKRSRMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVH2</accession>
    <name>A0A1E3HVH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Proteasome activator subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028231.1">
        <property type="nucleotide sequence ID" value="XM_019179809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30197038"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="517"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1502"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="2003"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN80327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2086" mass="235309" checksum="614550E3B53D3763" modified="2017-01-18" version="1">MGAHTALLPSAPTSTQRPQYGQATAESGAFNYDDKYYEQEDYDLEDELAQLEEELDESDSDNEEEGATFVQMSETWPSKVPNRLGEEPDDVRLSSVGLQLSLPYEVETIAEMDDKLDYICCKLVECVKAREFDQGFRVWDSALSIWQTMGYAMKRDVKIKLIFLYYEIIFLPGLSSGIIENAANMFTTLASDHSLTIYDFRIPWRPLYDALYLELFPHPSKLARHSVNLAPTLLNVAEDAQRFFHPADVDEMLEAIIPNIQGSMDSILATQTFLVHFLPIGNCHKWLPVMFRLWKGFNSGLWDDQASDLVGQLALAHVDPSRSDPSLFARIPHNLQNTPQQEADNPSERKRQRHHKMRQLEVDGKVEEDADGLNFWVSPSLVGEEEKLGDASWKGIRKDVGIFTDEEFEFIMSKCLRSLNVPVGGNAASQNAMSVTVADTRVSKKVVEAKKPIDRVQSLAETIVYSMSEDSLPAISTASGVATPVKPAKGKGKENLGGIGGKKERRYLGGSKALDHLSRLLTSCETFFHPSNSGHWSNFLCTFLSHLASNFVERYKDEEEPECRTPTDWRLTPDIKREFVLCLRPLALTAIFNKDMKVVSAAVSALKQLSLLEPDLIMPAVMERAVPSLQGLEETQRTPAVIYTLAALAEPLIARRIWRSGGMYAADIFALLLPGIDLNDPTKSALVSMCISNAVDFIFLADIADGDSIAEPTAAEENARAVRRVERAKVEDDPNDPVLLEEEDLSREEVDSRVRFATAAFRDWVPEFLGRVLLLFGNLPEEGGKSGRAGGKTEQVTLQSVLHTCGTVFASLDNKLFDIALDQIFEYATTTCRSNAVEAVGELVRNLASHNAPKVFDKFFPVAKHRIISELKSGASSTRTTTTSIPLPSDATLHWWQAILIGCLIPGRTRVSFNDNNSFLELLRIMIDSCLSERGYAWTGKIIEKTVSSLTSVYYTEMKMLNVDTFESADFKANHHLYWGKLYRPSEVKPQWKMPSKEDVDMAFEVLALADEAAGRIGKLVQQERGEMGDKEWSNEFCRAINVVDKVLRGSYNLIEEIEDRKVGGKQAPSFLPQNLYAELPKYRSGLVLTDPSDPRYLHVEGFRHRIAETLHQAANSMRTAGQSENSVESVRFLVTTISTYLTCYGVRSKQFANSQGALSAMTQTKKLLSGQRKHHRSIYLANGTVYHQTRLTTLAYYRKRSALDDKLIVNMLDFCLSPFVRVRRSAQSALDTVAKLYRGVWVLCFPTLFDALKPGTDPDIMKGALYVLRYNHIGINRIGKDWRQLLELTEHLLNAHHETKASVQALVAKATDELVGRIKEPLSFNMDVRLEAVKKAADELAGVLSHTPSQELIGDLERGTAERLTHQDEQWDIFVDRVLAKAQTPGLNWRYVLSAARFLLAVMRRDRPLDLRLTAFFMDNVQNPLPRVRDYGIVGVTRALFQMTLRSLCKGSEELLFLQEPIDDFTKEIPLTDTSPEFTEKYLQSFREPVTDESETWLHDRVESGWLAWGKKLEVTRFSGWDEPLFPIEEASLPARDLIEKAIAQEGWWQSLADLWAQEAERNYPSATHIDLVLALSQIYGIQIFHYVRPIVEGYLAEMEERKVYDRHKMRAMWEFLAGVIRGGIEWPGKDRKILWDWFTPKLPELYGNIRHDTTKCWDTSIEYILCEHDPRRFLPIIDFCMNTALNADFQGAAAFQLTRSVQLVRSALRCLQWRFNAWADDVLAVYFKEVGCGYAEVRSLLGSVFNAADQFKFHPSYPNAAAFVTAILEDPKDEKDIMHIQSARYQSELMGIFDSLPGLKESREHGPKAVLSEHDKIAMTALLWMIVELSDVRAVSAFPYIIPILPQIFELREMNDNLDLQRTCGRLLAMITSITPALTLIEPLTAKLVQILQDSTSWRTRMNVMPVLSLVYFRNLALLSEGCKVQCLDAVAACLRDANQEVREMASATLSGFLRCSQRAMVEILKDKFTREIQSITLPRRRAPGQINPGQVNPEYQEKMVHLHGAVLGATALVDAFPYTVPKFMPKLIADVLAPRVSDPAPISTAIRACVASFKRTHEKYQDKFSEDELSSMNYAQAGNSYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYA2</accession>
    <name>A0A1E3HYA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028259.1">
        <property type="nucleotide sequence ID" value="XM_019179778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYA2"/>
    <dbReference type="GeneID" id="30197005"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="39370" checksum="9D148517B550C4A2" modified="2017-01-18" version="1">MAEDELVRMQEFFRIQREEWWKWPPIHKDYDKDKSKPASIIQRIEEGTDEYDDSEEIAYREWMREFAPKQAIPASSWKDDEEDSGENQDSDKTKAYKSEAEIFRHIYHPSALALVNMECLRPVHHLILDELFLVKPSITVSLSKYCYEYFIPKLYTKVCFNDPHNIPVTGFMQGYKSPNGRKKEALRLVREVCIYFPPLVYVPKGELQSDGTREMIPTYRRQGVRTGYRHSWQTLPPGAKEIPLLHWEICQELGLRSSIYPDGIYMPNAEKTTFCGYMGDYLFKGNLEAGNVSRYRLGQTNYSTQWLMKTIIRLHDHIGFRPEHKTLCDPGPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1X8</accession>
    <name>A0A1E3I1X8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028334.1">
        <property type="nucleotide sequence ID" value="XM_019179717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1X8"/>
    <dbReference type="GeneID" id="30196940"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="12956" checksum="135FA1EDBA0316DE" modified="2017-01-18" version="1">MEYVLRRRVLQRGSGHLEDRVQWPINTRGYYLWMAKYGVTQPYDVMSLAYFSSKNRDIKTEGGSDYANQWTEKVAEWIREYNRLCRPWMNHPSFRSSDPSLLCRRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I3P1</accession>
    <name>A0A1E3I3P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028313.1">
        <property type="nucleotide sequence ID" value="XM_019179696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I3P1"/>
    <dbReference type="GeneID" id="30196919"/>
    <dbReference type="OrthoDB" id="10547149at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10217" checksum="7CD88C941AAE0B2F" modified="2017-01-18" version="1">MFFNIFTKKTSSSTAKANNTQASNDAPTGQRDRPLDEDEELLRLRGGAKTRAAPPTTAPVMHIAAMAMPIMTLIRQQHTCRRAGVAYIAVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5X5</accession>
    <name>A0A1E3I5X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028382.1">
        <property type="nucleotide sequence ID" value="XM_019179614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5X5"/>
    <dbReference type="GeneID" id="30196835"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="400" mass="44960" checksum="BBE59AB77B691B66" modified="2017-01-18" version="1">MPSDLSYWLIAAPLKHGDPDIMLQDVRDEVSGVTVAKWEIPELKAGTLSNLLVLSDALPKLDAQFTNTVSKLLDQLRTLVSDDPSKLAQHARINELPVEEYLLGNGEGFKWDRSRWGQEGKVDEVVGALKKEIESIDAVQKTKYQSYQISKGKLTQIQRNQSANLSSRSLLGIVQKNHLVPDSEYLETLIFAVPKNSVKDWNEKYERLTSMVVPRSTQQITADDDYVLQTVTVFKKVRDEYIHKCRENKFIVREFTWDDSALEKLKQETADLEVEEKELWTDLLKLTRVNFSEAYQVLAHLKTINLFVESVLRYGLPADYAGVIIKPESKTAAKTLRTINESYANLALSSSSNSSAKKGKGKDKSSGGGAGEEVGGEFASVMEAEYYNMVFVELPMVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDB2</accession>
    <name>A0A1E3IDB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028776.1">
        <property type="nucleotide sequence ID" value="XM_019179295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDB2"/>
    <dbReference type="GeneID" id="30196499"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="76" mass="8452" checksum="6ED050CEF2163C3E" modified="2017-01-18" version="1">MSLPILPILPSLQTRPGAPSRYSSIRHRRGWLASAFLGETVGVFQLVGGEVGVHEEEEEEEGERERLVVQPGRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDM3</accession>
    <name>A0A1E3IDM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028556.1">
        <property type="nucleotide sequence ID" value="XM_019179415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDM3"/>
    <dbReference type="GeneID" id="30196626"/>
    <dbReference type="OrthoDB" id="2575515at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="144" mass="15262" checksum="FD280310C8BD27FF" modified="2017-01-18" version="1">MPYPRPAHTIELTIGHVLTDSQFEELEDLTFLHFEGDAEAWPISLKIVSEFNQTTLIPAPPPIPASPSSSISSTGSRSPSDSGSPPPPASGGGGDLEPVVNKKTTTISVAVSREWDPASEEAVRTIVRNILMEIMGGGITVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFN9</accession>
    <name>A0A1E3IFN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028980.1">
        <property type="nucleotide sequence ID" value="XM_019179062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFN9"/>
    <dbReference type="GeneID" id="30196255"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN87420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="713" mass="80202" checksum="E5B3FCD291D5E1C3" modified="2017-01-18" version="1">MDKVQFQLESTLPELKDLHEKGLFTKNEINEITRRRTAFESALIRRIQRKEDFFRYAQYEINLERLRRVRWRKLRYHINPPPPSASTYSIQRRTLYILKRATSKFPQDLSVWLTYIQYASREGMRKVVGQGILVRAMQFHPTSSTLYLLQAYYHLHPASPFPDSILPSSSKSPLSLEEQDPDDVPIFAIEGISPARTALLMGLRLVPASPEIWTEYVKIELGWVEALRRRWKVLGINDINSKGKQVEEPEFEGDIDALRGGEGAFGEEGEEARKQILSGQLVIHALTSALKAIKPEAVIEGKKVGGMWYRQTLLDLFRGYPSPLRAKCLGVVYNELEEIATSVSEAASQARLLSISRRLFEKPYAEGEEPVKEGEYVLSGVELVEEFGKIGKNIRKSAKGAQSQQWIEVAGEWLIGRIEKHGDYPELRDYLLSLAGSLTKSSLHPPASYLIAHLHLLSSLSSPELLPTARAHSAQYPANATIQSVRLSSELSSASADNNDETRKMCETVARSVILSEDKEGVLAIWKTWASWENDVSSPEQLEKRWEYILKLSLKIGSTVVGLHDQLLPAYILSLYENTSQGLDVISKSVLGRYRPSPMIFAQVFEALKSSERSPSPQEMQGFFQSWKALTRSPTDLFEVSAAHLTYLVETGKGAEGYKLYQTARREVGEGLEGQLESVWVGILEKAKEEEEGSSGSGSESESGDEDEEMSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IG27</accession>
    <name>A0A1E3IG27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_06999</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028935.1">
        <property type="nucleotide sequence ID" value="XM_019179017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IG27"/>
    <dbReference type="GeneID" id="30196210"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="20">
        <location>
            <begin position="376"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="900" mass="98661" checksum="0D8ABFC7539EAAAE" modified="2017-01-18" version="1">MSDPSKTPPEPCPLCPPSGPPQPPPPAADDPSASPSAEVDLVWIACNKCDGWYHSACLFLSGEEWRGTVPSRVKEEVGVFGERGPWANWVDWIGKWYCAPCISKSTDPSNPRPARNALHATLKRSGIQPKDVELASRPLKREAAFHDTKPLTKKARTSTSTSVGGKAESISTRATRTPETVISGVHGGSEVNGAGEAVGQGRPKRKAAQVTDYNNLHNSIATPTAKWLQIIANPEEYGRTILDADYPTLPGHLLTKEWLESLPPPTPKNPTPQAPPNIPSPSIFHGPDRTPLIIRPSDGGFSSLGGHLPSSITVRDIARLVGPKKQVDVIDVASQQSASWPLEAWAEYLAPPETEEGVREREKERRKVYNIISLEISDTELAKLVKPPRIVREIDWVDNFWDFGLGKKAKGKGKANAQAQEVKVEDGDGMGREEEDDIANAKRNSTVDYPKVQLYCLMGMKGAWTDWHIDFAASSVYYTIHSGAKVFFFIKPTEANLKAYAKWSGSYEEQSNTWLGDWVDHVYRVELRAGDTMIIPTGYIHAVYTPVDTIVFGGNFLHSYNLDTQLRLRQIEIDTKVPQRFRFPNFDRLCWYVAIKYLTLFRSLHPLRPPTSSSSSSSLSTPPPKVPHHTILQNLLHLTSFLNLQIKKLRDDGPGGVTEKTRKAIWERIPPELRMGGEAGMAEGLVRELGWRVTDELDALGLGSAGSAPQIIGSVAPQVEIKDDKSKKKEKEKEKKSNRVAKVFDRDPASRTWHFDPPPWQESISIPHTETRLVPLPLPLPTPLPIPSSANGNAAKAYYDPTPYLAEQTSSAVAQSRVRVRQMEGGVVVEEKQTTEFREWKTVWGRGGASGMGNGGGMGSGAGSGSGMTGPQGVWGWGGHWAGGHAGHAGHPGHPGHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHI1</accession>
    <name>A0A1E3IHI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029125.1">
        <property type="nucleotide sequence ID" value="XM_019178848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHI1"/>
    <dbReference type="GeneID" id="30196015"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="42855" checksum="1F733CFDDC7C9DFA" modified="2017-01-18" version="1">MNNPLLSIQSQYWAVRDYLSPVLKESKFKEHGRITPEEFVAAGDFLTFKFPVWQWQKGDGSKAREFLPADKQYLVTRNVPCLRRATAVDYTGDGDTEQLLSFFDEAPGPGKDDEDWVATHIGREPTHDASNIDEIPDMSDSPELDASSGPAREMAGLDLTGQGKMVEDEIPDIDDIPDMDEEGAGLEDVEDDAAVKIVHPSEAEVNKTRNSNLLQVRTYDCIISYDKHYQTPRFWLFGYDEASPNPLTPAQVFQDVPADHAFKTMTMETFPHSGAQLASVHPCKHASVMKKFIDRMEAAQAQQYAPEQPEASASVGGEKDKDKKKKWGIGGMVRKVTGGSTPKVEKKDDDGEAPSGVPVDFYLVIFLKFIASIVPTIEVDSTTATGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHI5</accession>
    <name>A0A1E3IHI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028956.1">
        <property type="nucleotide sequence ID" value="XM_019179038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHI5"/>
    <dbReference type="GeneID" id="30196231"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="177" mass="18837" checksum="24A2B2C9D2C8C8AE" modified="2017-01-18" version="1">MSPQIYQGGPPRLLPRPRTPPREGLPPVIPTHPNSLVRLPTLTHLSQTHHDAYPPKPPAPPPDPSSRHLYPQPFPDPAPFTTKEVVINPPAKEDKQVRAFWNGMRERGYGVGVGVGGMYAGRWHPCIGVVGPGGVGAVGYGQVYSYQPPMMYGGYYGGGGGGYGRPGPGFDGGFGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHJ0</accession>
    <name>A0A1E3IHJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiol-specific antioxidant protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029132.1">
        <property type="nucleotide sequence ID" value="XM_019178855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHJ0"/>
    <dbReference type="GeneID" id="30196030"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="24989" checksum="2D2994E5DA90589A" modified="2017-01-18" version="1">MALRLGDIAPNFDAQTTKGKINFHEWLAGSWAILFSHPDDYTPVCTTELSAVALSYADFASRGVKLIGLSANNIDSHEGWIKDIDALSKDGANVEFPIIGDEDRNVAELYGMLDRLDKTNVDKKGIPFTVRTVFIIDPNKQIRLTLAYPASTGRNFPEILRVVDSLQLGDKYKITTPADGKEVDKVIVHPSVQGEKVKELFGDDVETVYPYLRFTSDPSKKEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHJ8</accession>
    <name>A0A1E3IHJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029137.1">
        <property type="nucleotide sequence ID" value="XM_019178860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHJ8"/>
    <dbReference type="GeneID" id="30196036"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="613"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1020" mass="109903" checksum="55A005C2F725FC2B" modified="2017-01-18" version="1">MSSPYPAPSSPLQNIPYPSINPPVAYNHAHPYSHSPNNYYRQPAHPQQQQPYYNRYPQEYPGYNGYPGAGGYGYMPMGAGGPGPATMQNGYAAYGEYGMVYGGYGGYPEYAPPPMRQQQQPGNGSPMNGDEGSEHSIPFPETPVPPGSTPQPPQAIPNMGPIPAQQFPPYPANHPYAFGGGVGYQQHPAHIPTFRPHPQHPQQPPHPHQAPYYPYNESYAPLPSGLAQGQGQGGGKLNPAAAGFKYQRFNHMNGNGERQIRPNHHNGPTFGNAGLPNGYGKGPRPPTQATPSASPVVTAPPSEVSSAPAPPSVPPATLPPPPVEEKEKEKSEEIKQVDGARTDPLLPPAASSATPAGPASLNFLTSSLSPPPAEQSKMEEPTLVDARPSVQSEGNTWARVLKDGSGRKVLKRAVRGAKTETKALWSTETQGDRTPELSFGEIDPEKKEEAVKAVPEVKTETKVESAKEPETVEVEEVEEKPVQAPAPIAEPQTKTVEKSEPEVAPTPPTAATPAPASTPVAPPKPRSWAALLQPSTPSASTTPSKTTSPSKAPSPNDGPAPAGPQPAQPAAPKFSYAGAASSSIPSPHEMLIKLLSEGVPSKGGKREGALVPRGLINTGNMCFANTILQVLVYCPPFTELFEEFGKRLQADLARKTPLLEAMIVFLREFLVAPTPADAPKPKGKGKEMNKQKEAFIPENVYDAMKENKRFDTMRRGHQEDAEEYLGFFLDTIHEEILYLLSRAQPPKPTSPAANEEVEQATSPLGEGVDGWLEVGKKQKTHVVRNTGSKDSAVSRLFGGKLRSVLHTPGQKDSVTVEPYQPLQLDIQAPQITSINDALLALSTPEIVPGVWSASRKENVDATKTVYVEEWPRVLICHLKRFVYDAKEGGVVKRGKAVAYGSELVVPQEIISPSKRSPTPTKYALFGVVYHHGSSASGGHYTVAVSKPPAPPAPVPQSAIPGQIPAQKKDERPWIHFDDEQVREVKEEEVVVSKDEVEEGRCGLVGGREKCAYLLFYRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN9</accession>
    <name>A0A1E3IHN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029116.1">
        <property type="nucleotide sequence ID" value="XM_019178839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHN9"/>
    <dbReference type="GeneID" id="30196003"/>
    <dbReference type="OrthoDB" id="2577675at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="446" mass="51444" checksum="6380E25510F7E2E0" modified="2017-01-18" version="1">MPSRPKTSLTNPEALPLSSLPSEIVALIYSFYLAQNPIENRSHFLNLITLSKEIYSENAWRLYEVVELDDQNCKAFFEGVWNASDFPEKPSRSQSPSVETDDGKDQSDMRGDLVDEIELFTPPGRPLERPTYLSSDSNAPYATYEYESHIPFHLHPCIRKVLLIRQCRRLYIDSWKAFDELQMCNHDVLQEAIYWLDDRASNDWAIEPLFFSVTHLSFGTPFMTSYQKNIATNRYLLGQFELFGLSLKHICLALCDDYYDVDSSDDCDCDALERRIESVTELLQEDLSFALWSTIDQKTSLTLHDARPEDFEDGLADTIIYEMPRKTDAGVDEWKKQIMMAEAEIGSHMSVLGYELRQGEVGADSWKPQFQPWKIRFTNMAPLPADVDLPQLFLNDCSYSRDGPNEQFEQVFRKWWEEVVSFEGPTKCECCDIFKKGHPKSPARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II10</accession>
    <name>A0A1E3II10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028931.1">
        <property type="nucleotide sequence ID" value="XM_019179013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3II10"/>
    <dbReference type="GeneID" id="30196206"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="30296" checksum="13F77DA738B0B0AA" modified="2017-01-18" version="1">MSPRPPASFLRLYPSTKTKEELRAVLADAGCGSPNQTDKDGLISLILDNADVPLPASWDYRGSRYHTFSFSSPPPPPPTSEQSMAQLNQTIMALFMKVDQQREYIDQRFREPIPAMPTSSVPVPSSSVPEPSVVVPSLPSAHCNGRRSKSRAAGNPFHQVPEGSDAEDAEARNRASVRREEPEFRDGIQITCSAEQTGSWQGSFTLRPPASRSNFTRQEWIEKVEAEGGTSWLDGSPTSMEFDVDMRLFPVGQERRSNMIALVRSGTYTWLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIL1</accession>
    <name>A0A1E3IIL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029256.1">
        <property type="nucleotide sequence ID" value="XM_019178773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIL1"/>
    <dbReference type="GeneID" id="30195931"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="161" mass="17346" checksum="4EB80FE4069303BB" modified="2017-01-18" version="1">MSTTTTTQNKVDATTKKTKAPAAQTGVENLGPAFDPFAPVDDLNDTPSIEKAVGNKNDKIHIRLQQRNGRKTLTTIQGIPSKFNHNKILKAMKKEFACNGTVHKPEVDSDEEASPAPGAKVNHGDVLQLQGDQRMGAKQFLIDSGIVSAKDAKVTIVVHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKX3</accession>
    <name>A0A1E3IKX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_06491</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029453.1">
        <property type="nucleotide sequence ID" value="XM_019178546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKX3"/>
    <dbReference type="GeneID" id="30195703"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000253">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="19">
        <location>
            <begin position="44"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="20">
        <location>
            <begin position="239"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="363"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="426" mass="48903" checksum="89D08ECA4D044ADC" modified="2017-01-18" version="1">MPAHTPIPDIPGERLQNPETKYHLASRVSQLCGLNSPDKFPGSQPVSFSTASLDLLEKKDFWVCEKSDGVRVLVFIVINGFSGEQETWLIDRKQEFYNVKGLMFPKWDDRRQPLGESILDGELVIDVDPQRLRFYGFDCLVLNGENIMSKNLEKRYARLRDWVVVPLEKHIRDNPEAKQYLPFEVLAKREDLSYHLKYVMKEHIPKLQHGHDGLIFTCVQTPYIMGTDENILKWKPPSENSIDFRIELRFPPIHDSDEPDYHAKPEFCLHTWLGSERYEFFDFMEMTDEEWESWKETGKPLDDRIVEVNWDGAMQAWRMMRIRDDKLHGNHKSIVEKILISINDGVEIEELYARSDAIKSAWKSRAAHPQTPAVHRPPPQQHQPHGYGYGGGAGDYGGGDYGGGYGQGHGYGQGQAPQGVVAGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM48</accession>
    <name>A0A1E3IM48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029583.1">
        <property type="nucleotide sequence ID" value="XM_019178427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM48"/>
    <dbReference type="GeneID" id="30195576"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="192"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="320"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="42082" checksum="D6E7BF77893D6D23" modified="2017-01-18" version="1">MSAPASPAQPTTPRQHAEHDPQLADVNMDIPDQPQKDKKPDEHNPFGGDSLDQAIRVMQRERYTVFPMFTTWAQDPNNPASPSQHANGDSPSHQHNQQAQLDSILSLRSPTSGEDGSADVEGTGITPEIRFSDEMAEQNVSAGPASLKDDGQQQQQAQQTSQQAQNLLAPPQAGTSQDGEKGKDSTFSRSPELRVTHKLAERKRRKEMKELFDELRDELPADRTMKASKWEILTVEHMRQLKATQVDHQRELEHLRRENEHLRATAYAHPPPHPHNNNHNNHNNHNAHAFPAYLPYHPNAFQAHNNMSQNVGGQNGVQGQGQQQQVQMQPPQPGQGVLQQAGLASQHHTPQPTPGLQTPGGDQGQGQMSGQVSAQGTPAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM53</accession>
    <name>A0A1E3IM53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029589.1">
        <property type="nucleotide sequence ID" value="XM_019178433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM53"/>
    <dbReference type="GeneID" id="30195582"/>
    <dbReference type="OrthoDB" id="5426988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="211" mass="23204" checksum="371DE2C701B8489F" modified="2017-01-18" version="1">MSSGAIILINGYPGVGKLSTAQRLTKILPNSKVLDTHHLKDATSSLFDQKRDVEAWNALHSGLRDAIFRSIKVSGNSRSQPIYILTESIPACPAGAKDLQSLLAHARDANFTLIHIILSCSTSENIHRLHSPERRFKNKLTDEGALMELRMEEEIARFGGGIMRKKVGGLGGEYEIDTEAVDPKGAAAIVGEYALDALRRQGWFIQLNRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM54</accession>
    <name>A0A1E3IM54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_06369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029588.1">
        <property type="nucleotide sequence ID" value="XM_019178432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM54"/>
    <dbReference type="GeneID" id="30195581"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="155"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="649" mass="71766" checksum="BCC5BC49D78886F2" modified="2017-01-18" version="1">MAASAASPFLFQSALHDSGLVHEMLSNPLKFGPPMVKKGVGLEGVTREVVGEKESPKVAKKKMVVREESKDDDESEASEEEDTPKKPVKKAVNGDKPVPPSPKVKNDKQTNSDASSSKSKLPAKATPEGKNTPGLYPVTFDLTWPEPMASAKHASGLYNPSMACYANATLQILLHTPPVLNLAMAHDPTDCTQKRKKNFCMLCTLKTMAEGSHWNGRKAYSPEVHRSLSQIKKGFSKNKQEDTHEFFRFVTDALQNTALANLPKDTPEKVKHTSFVYRIWGGRVRSRVVCSRCNKPSDTFDSFLDLSLDVNRQGKKSIKGMMQGFTKEDKLEGDNKYHCDNCKKKANATKSFKIEQAPPILTLHLKRFSVNYNAYSGRARAEKFNQFIEFNEKLDIGPYMVDPNASGSKYRLFGVTCHRGTELRFGHYTSYVRGPGGQWFHADDEDMSAVRLEEVLRDKTAYLLSYVRVGDGEWDVTPKPIIKARVGGLVNGNGKDAESSSEEEERKSPSPVKRRRTVDSDQPVRMKVNIVNNPKPIPAPRQSSSSSGDEDTEMPPALPTKLGNNTQTSKIHAPKPVDSASFYASPISRPSNPLAGMSKKEKRKFKQSNRDAGKGKSKSSALPMPFAQGKMGGTKNRQPGVLGRMKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMH2</accession>
    <name>A0A1E3IMH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029534.1">
        <property type="nucleotide sequence ID" value="XM_019178378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMH2"/>
    <dbReference type="GeneID" id="30195524"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN89625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="226" mass="24854" checksum="0A61FFFED2E88AE7" modified="2017-01-18" version="1">MSTTPPSQPHHHGEDALYAQEDASELHDTPEEKWTALAKIVRDVGPNLSPDEELGDLAAAEAAVNAKDAERNEILDKIRDDLRQLSRQLNQATSAAQRPPSHPSPDDHDAHVRSLEQQQYSTGKQLNDEQAAVAKKEVELGKWKAAKEEIGKVEIGEDAESWADGKVIRLKLFSEAGFSLVPPREGSSASKILIRNDAKDDVHSVVVDNSRSKVYTANLIWNLASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IN63</accession>
    <name>A0A1E3IN63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029426.1">
        <property type="nucleotide sequence ID" value="XM_019178519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IN63"/>
    <dbReference type="GeneID" id="30195672"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="31469" checksum="D900B266B247CEDA" modified="2017-01-18" version="1">MRFTNRPTGEPRERWGKWPWAVMMWRDGKHVMKELAGQVRDGLGVKWEVAEHWARDADTVGLKVILASPNPVVAFHAANMLHQLVALPSTIPESPNIPSSKTTNSTPTSYSHLATLPSMNGPAAAYATAHDNLLFNIVQVAQWYTGQVVTTDGVVRLVIPPVSLDKVDQAQKRRLDSEIPAFSVAGKKGLAIIRHIRSTIKHDETRRVIVKQNQLFNRLLGFIIIFVGIQPQRRQKGGHIEYEIEWLRSFIVLGDLSGPCRDMGDIFFVASTRCSATEHVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQC7</accession>
    <name>A0A1E3IQC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029840.1">
        <property type="nucleotide sequence ID" value="XM_019178121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQC7"/>
    <dbReference type="GeneID" id="30195266"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="75708" checksum="2EF690BE9606C33F" modified="2017-01-18" version="1">MSRPPPLRKPSNLSTRPPSPQRQNSNGPPITPTNFSYPQLPGSSHHALYSPRRQPLPPSPTQSNVSYASYASSGKASSGVGTDMPPPLPPRDKRMPASSQGVQASPYRGRAGGYASNAGAYDNKLVSSTLSHLPPLPPLPHSPTPSNTSHSMRPAPSMNHIHASPRPSLSNASTSHLPSNQASSGMVVFPDGTPLSDHAQYPTTTSLLSGTGAHGHDLGVLGMGGGGKAESLAMAHTDPSGPWTLLTVHVLPLFAGSAMKTPIEDLNSLCRSHIVTTSQRSPPARIVALLSSDLREFIASGMLTLRAKFETLEEGKMVSRAAEVWSFFWTQILPYVEGVFLPFTQLQSVPTNNTSSTSAPTVRITSSLPAIPVRHLLLSGFLLHILLPLLPRLIPLVYPPPTPFPSPFNHPSARSSPMPSPGSHLRAVNPPSTQELSRLLQMSLVLSTQAKYTSFFPPTSIYNAQDRDRDEEVRSNVEGLGQAVRWQNRRMEMEAEAAAAAALAGGGSESTPNSAGTTMPSVYSNPSARNSLNLQRRPSLPGGGISGRHRRRGWRASSYMGQLGPGGIGEWGQNHMGGPKSGTMSRQGSGYAHGYGYPVEDDDDEDITPSQTIPAQGPHAASSRTVSGRERTGTTDSSSAYSYHITGSMMSAQTGMTSLAGQSTATGSTLTAPTMAGGESLASYGETPTPLAGGVLRGNNGGRENMVYGRPAGLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISH3</accession>
    <name>A0A1E3ISH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030031.1">
        <property type="nucleotide sequence ID" value="XM_019177992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISH3"/>
    <dbReference type="GeneID" id="30195131"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="268"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="418"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="604"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="765"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1033" mass="111246" checksum="243900EF3449E72B" modified="2017-01-18" version="1">MSAAGKETDKEDVPDIETAAESIISTLSASSQHTTFIRLLQRSKSVPMLAHIGNATVFAPTDQAWKEWAERNKPSSKAFEEEVDDRPDLIHGWLGPEGLDDWFQDEAEVLLARVAASGNHEEEVRAMDNQNWALRQHLLYHMLNYTLTPKSLLASEQVNNVTLQTTLLYPLDEEPPLPPMPEPGPPWLPRGGEGLLGGHGQRLRLARVGSEEGGKRGKIGADWKGEGGVGVWDGSGWKAGNESKHDVTGVKWTRNGVVVGIEGVLDPPPSIDVIIRSHPSLSYLAKILPLSSPPAPLPASFATTPHLTVFAPSNEAFLSAFDDIERGYLEGPYGDEGVGRIVGQNVVLGQDGKGVGWSDLLGKESDFEAACGLHLNVSSPSRNEVLVNDTKAEIIDIFASNGVIHIIPNLILPAGFDLLNSAEKMLLSLNATRFVSLLRTANLSDAYIGKGSAEKGGDSYTILAPTDDVLDTLDKWGGFSAASSNHILAHEMTSPASMSPIGNTPLKDVSPLAALLQYHILPGKLLPQDLKDGQLLPTEMRTSALGGERQRLRVEVAEKDGNSHSDWETVGEGKVRLGGATVIGKPVKSGNNMIYLISGLLSTPDNVLQTAVSDLELSTFVAALYAADLAKTTKHYPATTYLIPHNDAFNHLGLTMKWLLLPDGKDDLRKVIKYHAVDGLVYSQDVNVGRQVYKTVEGGDIVIERGKGRHRALTVGSPNKWPGHDSSASLPSNGELFPANISTSDALTDTGVIHTIDQVVMPADVGITIAKLVKGSKQSTMADLMNHAGLGWVLEGREPTYTVLVPTDKAFGRLNLTYYTNNPPALLDLLKLHIIPSQTQLPSSSSSSPLPPPPETIPQEGQPLSLTDDTVYGTLLSSRSKFADLAFRNAGDGSWIVGIQNARNGAGGDSARVGASGRASVTWRNRSAASKGHKDKHDEDGDDEGGDGDDEEWKKLWRGGMTLGGGVLIIDSVLVPYEISWFSRWGFLTVTLSGIGILLLATAGSIGYWFWTREKEGYEPILVEEEGEGEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITZ3</accession>
    <name>A0A1E3ITZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase ICT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030193.1">
        <property type="nucleotide sequence ID" value="XM_019177809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITZ3"/>
    <dbReference type="GeneID" id="30194943"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="3">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="186" mass="20955" checksum="8D4FC000635B3943" modified="2017-01-18" version="1">MHPPRLSTRLFSTTARLCARPPTELLALSKLDSDAHHALASAWARDFVVEDIPRSGYTETRSRSSGPGGQHVNKTESKVTLRCELDQAVGQWLPKFVMPALVKSPYYHPSPPCILVSSQKERHAPLNHAHALSEISRIISQAAKSLIINPTSPQQKARVKDLERREKAKRMELKKRHSMKKASRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU11</accession>
    <name>A0A1E3IU11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030172.1">
        <property type="nucleotide sequence ID" value="XM_019177788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU11"/>
    <dbReference type="GeneID" id="30194922"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="43490" checksum="1DEDEA8932D3E06B" modified="2017-01-18" version="1">MGLSERKVKQRIGLDPRNLNWSENKDRFSYKHMKALGWEDNTGLGSSMVGNANNIAVARKDDNGGIGMARARKEGGDMAAGAGQAGAGLEDVLRRLAGGASPSPAPASPKVEEERPKVIRNKMASRQRHLMAKKAASQSPQALAEILGIPVSALPASALASPSTSASSTPKPEPEAKVELDDGKTDEMVTTSTLSVSDYFRQKMREKMAARQAASGASAPAELPVHSLESLASLPEPKAVGGTAWGGQKMQFEEVKEEFNPSEATAEIPREDAENERKRQRKEEKRLEKLRKEAVERDDAAGRKGKKVKQEVKEEVVVKQELENDPLHQAHEQLEKFEHAGEDVKPVIKEDKEEKQKRKEQKRREKEEKKREKEGKKRKREDGEEKKSKKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU58</accession>
    <name>A0A1E3IU58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030261.1">
        <property type="nucleotide sequence ID" value="XM_019177877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU58"/>
    <dbReference type="GeneID" id="30195011"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="140"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="406" mass="46658" checksum="184E7AF300056962" modified="2017-01-18" version="1">MPSLGPTIEQRAHIDRLVSSIPDRTLPTYQHPTHDQLLRDHLIPNTPFLLTSSNTSQWPAAKALRTPGAKTGKASDPDLRGLRQYAHHVVPVANTLKPQFSEFERTERPLGEVLDLWETDINAARGLYVKDWHLMAEIESEGRGVGEVYTVPECLRDDWLNPPYTPSPRATHSESVSTSTSDFRFTYAGPALTYTPLHRDVYGSYSWSANVVGRKVWWLFPPDRLDKIKDQNGELYFDVRDLEDEGEAIKVLQQEGEIIFVPSGWHHQVLNIDFCISINHNFFSSPTLPRIYATLCLGQNRVEESILDVKEMIIDRLGTKDGSWEKEWFDEVQSLLEMDAGWNWKGFWATVKKNLEMSPSLEHDLPPALLQYDWVREVIAKYKERREWLVLDAVKNIVLDIERLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUA5</accession>
    <name>A0A1E3IUA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030286.1">
        <property type="nucleotide sequence ID" value="XM_019177902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUA5"/>
    <dbReference type="GeneID" id="30195037"/>
    <dbReference type="OrthoDB" id="2575493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="6">
        <location>
            <begin position="566"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="630" mass="67558" checksum="0186484461A6B857" modified="2017-01-18" version="1">MANQPPPTPWIPNPRFADESLLLEAQPIFDTSLGDESVWGGGATVICNGASDQDITSNFSLKAGGETSGADMTFDLGDYLPEEVVAGQAGMSRTQAIPPSSTQRDMRAPQQDLSTLIDKASTSGKQKRERESIDSLSVVGPSKRAKPHPKENDDLFSEKLPELIHPKKAESSKPAAQLSANTASARLKTQLKRKASDTGKEKIVKTPLAMAKTESSSSKQSGSALSRYLARSTVLAPKTSAHVEPKTSSRDVSPALPHPILAQRPIAAPTRLSTPPSVPAADPSPTLASETTQPSPASKPTNSRPSVVISPPALQSRPDGETSMTKAVEKSARGSRGPSSDQGPSPRVADEKTEMEDVECSVNDEVAKESLAEVQHEQITAKPIAESTRAPLTGPMRRKPAGLTKPIPFSRPLSERPQRTKSQTVSTKPPVDSKKAGVPARPLSRAPLRSTTALVNARPAPPRAASKPKKPTSPEGKRDLRKPPIPSSFAASSALARPLKSGSGQKSTAEPVKVKAKDTENARGVFDRLASTTTHTSRAPPAPKAPKHSSLQPTVPLRGHTPGKSSALRAQQRAVFDKAVREKMEEQERVAAEERKRREEEEEEAYQRQRKETVIWAKPVPGLYREGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXT7</accession>
    <name>A0A1E3IXT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030558.1">
        <property type="nucleotide sequence ID" value="XM_019177405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXT7"/>
    <dbReference type="GeneID" id="30194531"/>
    <dbReference type="OrthoDB" id="2566675at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13390" checksum="45226ED869A37F8D" modified="2017-01-18" version="1">MFGLHPLTSTYPGASFHPNGNLNGPHLAMQSGGPSQGYWGFVPWEVPEMPEWDLPPAIKAMQEGRGSGMYGITPEGGGQGQPFNYGWPRYGPMPLRPQLGGFVGKCNPYGRSWPHGYYKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY80</accession>
    <name>A0A1E3IY80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030669.1">
        <property type="nucleotide sequence ID" value="XM_019177516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194643"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="893"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1498"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1457"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1677" mass="181865" checksum="EBB2E4249646E969" modified="2017-01-18" version="1">MAPGPEGIPPEEEGNITVEDFGAEEHEAAQQGAQDGMKGKPQTQEEWDTFISSYSVGNTARYTFHSEDESDDPSPASRLSKESPSLERQSSTPLSNERQASSSSLEPPPRPLLHHNPSSLSHAVLLPSGSSQDPVDTSGSESRSDVAGKVTAAEAMNQDPAIPDIEDKYLPSISRSSSNAPSQASETSSKKGYRGQEAMTSNNMKRLGEEYRREEVKKASTEGSGKKAKRKIVEKATLENSSEGEGERNAAVEEASVRRKSTRRRPRPRGAWSSASHNGEMLRRDSKPSLDMSLFDDSTNTSTSISQADLAYDHAAERTRIKEFFEKNDFLCPPKQPPGAYRRRLRVIRRMGLEQPEGFHCDTLDKLSRLAKSFFRTQSVVISVFGRSRQIFLSKIGIDARSVDIDKSICCHTLTLSGNSEQCMVVKDAAKDWRFRKNPMVGEGRGPVRFYAGSPLKVGSDSKESIIGAICVFDTQPREFTRDHRALLADLASCVVSELELLYSQQASIESAKLHQISVDFLRRSLKHRPLEYAGQSNSGSTLSGSSGSMNVEGDPVNPTEVKSVPTPAPTPASAAAPDTGNSTGEEQDDSAEDSSPFSEESPPAAPLNSKKRIEGADANQSVDAVDIYDEACIEIRMALDAYAVAVVDLSQFHLFYPAYQSTTNGSNSIRTGSVTEVPGRKNKSGPSTKGGSTARQSSSSGHSQDDNEDGLGFDWSNKQRRARPTYSVNDAVQPARTPQVLFVPSRPTMRSKRYRPQQENDDSLSVLGYSCGSDGFAFNFTSSPAARKIIADFIASNVVSRKVWYARDDSQGIAQSITHLMPPGTETSMALPVFGFDGQVAFAVVACWKDPLYTYPSGALQFVETIAGSLLASVLKERLHKAERAQLNFASAASHELRTPLHQINAAASLLRSFVQPVFDSMRGDEDVHVPPEDRVEILQQLEIIESNGLSLGNILENIIDTLDIGKMASKMDTGGTIPSLVHKDTATGKEAAPQLTSLVEVLEKVVEDAIELESKSRKVSGGKGMDQVEVILEVLPRKRGGWLTTRDVGPLTRALGKIVHNAVKFTEKGHVHITVQDLSREVALPTGYDNSMRESTISIDVKDSGVGMSAAFLEKEVLQPFAKENPFTSGSGLGLGLAQRMVELVGGKLAIASSPGKGTLVHIEAPLFFLNGDSISDDENLNTNRTADQVMEPDYKIRQDGILLAGWENCKASVKRVAKSLVRQLKLHQCRLVTEAQYACVIVMPDGSLSDAQLAAMCRAARPGVQVIVLEKDRTKYGQGDANSPCLASSNPNGVTRAARLACPPRSPKGKEDAAFLATIPFLHLSRPLRPSILRAVMAPNDRPTTPPERYVSDVVGGEDARMGARMPVPVPVGTDIGQQAVGNDEPISPLENLCTPPMSRNNTSDPGDPPNDPLATPIPGSSREAPVRSQSLSVIDSRGSTDDEGSEDRPQYTASIISDMSASDSSEGVMSSIGSENKQVERRKRVEMDPSALKVVLVVEDNSVNRKILTTMLRRATCHFVEAVDGVEAVEQFSAFLPDLVLLDITMPKKDGFAAAAEMRQLETKWAGRLRKGCVIPGTTDEDLEEAMVSMDLEPQSQTSSAPRSAIHRTGSGRKRAKIIAVTAMSAEHQKRKGLYECGIDHWMTKPLSMGLLKSMVEDMKEEVKRGLQGVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYQ7</accession>
    <name>A0A1E3IYQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030468.1">
        <property type="nucleotide sequence ID" value="XM_019177717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYQ7"/>
    <dbReference type="GeneID" id="30194851"/>
    <dbReference type="OrthoDB" id="2576041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35606" checksum="544A3B3431BBF1F6" modified="2017-01-18" version="1">MSTEKVRDPSHAERGLPPSKFRKSDFFNYHPPFSVLLLEFLVWLFLFFVCFLEPNGGLAAVIRSDDEYIGLLKKCSASSCDGWMQGATSSSSDSSSSSSDALRRSLTPRAIDSSIDLANFYLTTGLAALCSFWLMTYTFLFTFYRFSTSPPPPPPTQGEEGQEEPKTRWGRMKRGWKRFVFRVSRLYVFFLGWIVLGVACAASWQVQKASGDGGSVGLALIFLHASWILLFICAFLEISRGSLRRRADLGWLGCLCLPFFSRCKTRATKKWERAEGGEADDDAQEGRTKKRKEDREGRSRSRTRTGRKRRERDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J043</accession>
    <name>A0A1E3J043_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030713.1">
        <property type="nucleotide sequence ID" value="XM_019177132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J043"/>
    <dbReference type="GeneID" id="30194246"/>
    <dbReference type="OrthoDB" id="2562734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="537" mass="58600" checksum="BFE2966F13E68B89" modified="2017-01-18" version="1">MPKRKSIDPAPPQPPPLSSLDAALDLLVCDTFTRLDSIAAKFEACAAVKLNDGVVHARWEEAVKRYWVMKSMDELTCSAEKNRAAGGNRNGYIGSLPDGEDGVMEDAENTERDGKSRPMPTAYPGAVSVHNLAADEEDEWRKWNPRLGNVVLVDTAHDGIWPGKIIDKKAFFQGRTTPRGNHFFPVRIYNEFMPPIISIKARLIPFHLRPEPPLLASASLQSAYHHAKNPGGFDVLATAREAHSARTRLHPGVTGEDNQAKYKGEREEWNTQVNWVMSERRMEKLRILAEERGRVLREVGRSASTPVFEANGESSATDERLDSIFGVPKKRRTSLPPPKPKLDPTIPALSIVPSAPSTPPPRTAGSPSMASYIRPSLSNQRTNSPRRTPTRRDRDKRMYALSGVGELSPAASVRRTYTPPRILPSGDETAPSGFGMPEEVKSGRFDFTSPLGPVKMGKLVPVNSKSNAGGADGTPPGKTGRSGSLEIVREEDEEEGWSIVSRKCRRAGSEPAGARVGLPLGEQGQGESTGGAEDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J096</accession>
    <name>A0A1E3J096_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030800.1">
        <property type="nucleotide sequence ID" value="XM_019177219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J096"/>
    <dbReference type="GeneID" id="30194338"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000116">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="281"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="494" mass="52777" checksum="73EE912B92216FB1" modified="2017-01-18" version="1">MLALLPVLAASASAAIVPNTPSLFIANGAHDTVPDCLKHSYHGSYGGSAAAQEHIYLPSVECLSSSNLDSFTAGSIVPLEDLGSLEKGRMVWIGKAGVQGDGELPMDISAHSWPSMSEDGKEQGSPFVIQTDDPRDTRKEPITLLHQTANSFLLHVGASALPYIDTLLPSYLVPVAVPTKPYPVATLGWESVPTKYAKYLAGIIENLQFSPAIDRILSDGLDLNQVRRDVRWLTGESPSGIQSRHSFTPGAVKAAHWIQGKVEATGATCTLQPFLEGFSPNVICQYPSLHNSTENVIFSAHYDSRGSFGSTRAPGGDDDGSGTGHLLGLAHAIGSQGVQFEKQVTLAFFAGEEQGLLGSHAYAEYLHSQNVSILLQVQADMLGYHAVGESLQLGLPETIHLPEASYLVGNISHLYAPELVVGTTAACCSDHQSFVSYGFPATQVFERNGDIVDPMYHNSGDLSQREGYDFEQIVAIAKVTLATLLTVAGYQIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0A1</accession>
    <name>A0A1E3J0A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030496.1">
        <property type="nucleotide sequence ID" value="XM_019177343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0A1"/>
    <dbReference type="GeneID" id="30194466"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="53138" checksum="F4F9DD9EA492F2C2" modified="2017-01-18" version="1">MADLGSVDTPALEAALRPITAPRDAPSAQFTNWAKTFVCRPQRVLLPTTPLQCRQILELARREGARVHPIGVGHSPSDLSLTNGWLVKMEGVKGLIKTDHDNLTATFHAGTSLHEIHRLLGNASPPLAMRNVGSISDQTIAGLISTASHGSGTSFPILSAHVKSLKIALPLPDVPVVTVSATQDPDLYKASLCGLGATGLILEVEVEVESAYRLRETKEGRSFGEVLAQLDTIKDSAEHVRVWWYPDGKGAVIGRANRTQDPKQSSPSLTAHFLGFHVTQFFIYLSRIFPSLTAAVGRWAWWLSKTDSEVVDDGYKVLNFDCLFPQYALEWAIDAKESKACLQEMQLWLDREAADANGLRLHSPIEIRWSSADDIWLSPCYGRETCWIGVVTYRPYGLAVPYRKFHERFAALVAAHGGRPHWAKQHTLGPKSLEVMYPKFKDFQNILQRVDPMGVLRSENVRRHIDGENIPDRIFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0N7</accession>
    <name>A0A1E3J0N7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030746.1">
        <property type="nucleotide sequence ID" value="XM_019177165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0N7"/>
    <dbReference type="GeneID" id="30194282"/>
    <dbReference type="OrthoDB" id="2592275at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="519" mass="56337" checksum="E382A8692D7DCB33" modified="2017-01-18" version="1">MDAVWDRFCPHLHPRPPATPHAAHPEWKTSLDSHVEVDGVGTLPVIRVLQEVTALCLWPSVIVALGMPSDPASQVRVPPPSAQSAMSLQQLYNLTIRHWEPSIFSGLLGAYASGTMPPPVAQPMDRAFQSHHYGPSTPMREADLTQWINLTPGAWSAQHDPFIGNGGQNTLFPRKSSLASTAFPFPFQLDDEKKPAEQDEQASTEDDNHVAGLDELLAGMEDQRDDVQQDVKPVENTTTQTFNLPTPETTSPDSPNTTSNKMVLSPPTTMSSPFVTAGSSVSAAPVPVPAPVPAKPHTKARPPQLSMPPVDFVPPPPMCMFFKSAFDNLTDGKVGIWKGDLEVRGRGGGKFSVLVVGEQGFDHLWQSTAWPQQLSYPMRSVSDNDCYTSSMIPVSHLAREGLVPITMGMVLCNEPADRIDPYVKMVHGLHAEGVAFHLPCDDPRLPVVFLPAKFHANDPLLRLGVAFMGKAGLPYPAAGLPQPTNQDAEESGVDEPARKKRRQSAPVPSKSKSRKGSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1G3</accession>
    <name>A0A1E3J1G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031009.1">
        <property type="nucleotide sequence ID" value="XM_019176977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1G3"/>
    <dbReference type="GeneID" id="30194087"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31407" checksum="4532898599AF07B0" modified="2017-01-18" version="1">MADHHFQVNAEALAAERVASILSLRDSVLNDIQKSSSSNAASLATFAREGARHIYLVDWQKKHILAIIETIKARFPNTTLTFIEGDAADAPFVKSVIDRVINDEGHLDFFFANSGVMELPEKEKEERIDDDPGKFLPELKFIALKYASKAMSLTCPERGKTLPGGSILLTSSTAGVKARAGPLAYSASNASIVSFAQTGSYEFAGRNVRVNAICPGLIQTEMTAPFLVPNLHGDSGTPAEGMMNPSLRHGLAHEVAEVAVFLSSSKASYINGQAINIDGGWTAGNPFMPRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1L4</accession>
    <name>A0A1E3J1L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030997.1">
        <property type="nucleotide sequence ID" value="XM_019176965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1L4"/>
    <dbReference type="GeneID" id="30194074"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="143"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="730"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116479" checksum="29DB7A197EE3FF22" modified="2017-01-18" version="1">MAPASVASSSSSVIPQRNHIAESEAGPSTKTPSLRSRSSARSAASSPISPKGKEREEPSDQADSEEESSSEDEEDDVTESESGEESVEANGAGHGDDAINGDEGHGEDEDEESEDESGDASDEVSDEEDSDEESDEEEEEPALKYSKLKGRIPEILAKDTASTISVSPRFIALGTHNGMVHVLSYEGVKVNSFRPHAAGVTCLRMDESNDFVATSSVEGRVVIHSLTTPESYAFDYKRPMRAIALEPDYAKKKSRAFVCGGMAGNLILQEKGWMGYKEQVLHSGEGPIWAIEWRGNLIAWANDLGVKIYDTSTGQRIGFIDRGLSAPRAELFKCTLQWKDDRTLIIGWADFIKIVRVRSRPSAPGSGNLHPLTVELTAVYQVDCMISGIAPFGGSYVVLAYIAPDRYENEATDDRMEQRRKAANRPELRIIEKGEEINADALSLGNYHMYGCNDYTLVKSQKSGDEAFLVVSPQDVIEVRPRDEADHVEWLVEKERYEEALEAAEELRKKHGGVLDVTGIGLKYMQHLVDEEHYDQAAALAHKVLGQDVSAWEKWIDTFVQHQQLPVIIPHIPTKNPRLSKPVYETVFSHLLLNDKPALVKTITSWPTDIYNLPTLIESIQNELDATNDDPTILSALGELYLINRLPAKALPYFLRLRKPYVFELIREHNLFGAVQDQAIQLVTFEEERKEAKKREEQEKADKGEAEKVEEQKDDGEAVPGEKSKHGAAIKLLVDHVHSIPIDRVVHQLRVEPNFLYMYLDALLDKDPQFCLPYSDRMVELYAAYDVERLMPFLRGSNFYDLEKAYKVCKERDYVSEMVFLLGRMGNNKQALMLLIERLGDVQGAIEFAKEQADEDLWEDLLKYSETRPLFIRALLEHVGSEINPIRLISRIRDGLEIPGLKPALVKILQASNLQVSLLEGCQRVLNGDCAGLMGKLQKAQVGSLKAASTSTCVVCSKAAFDPLQPELALIYLCRHLVHATCVLPEDVELPRRQENPSVTYLLQGNDKSGGVSSQAWKTRALGSTLGYAAAVRVRVKQCPICEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1P7</accession>
    <name>A0A1E3J1P7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031072.1">
        <property type="nucleotide sequence ID" value="XM_019177040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1P7"/>
    <dbReference type="GeneID" id="30194151"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="203" mass="22754" checksum="D8240E99BFA3C9FC" modified="2017-01-18" version="1">MVESLARALHTKVKSCRDHFEQIHNEQDTVESRVNSYRASADLYAAEGFLKDHYPVVFDSSNSKTLQQEKHMDAIAAKQYLDMAWEASRGLEESPPVEELIDKLSLAPEQSRSVQLSLETRETATAGPWKSSFNWAEDEDDEEWWKDEISKLAAVNKSQEDDSMASDSRSAGGDDGRSRLSAPAAENENAWFGPVPASRRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1W7</accession>
    <name>A0A1E3J1W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031101.1">
        <property type="nucleotide sequence ID" value="XM_019177069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1W7"/>
    <dbReference type="GeneID" id="30194182"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="31406" checksum="BEAC87FA1FC0CBC0" modified="2017-01-18" version="1">MPPPPPTVTPSHAQEALNSAAKAVDRLTNITTVLGVVAQGLGAGGGWMPGVGLACNLVCQILDSAAQVGVGKISALKLVERCALVVEAVGNAVQSCKGKVSNAMQRNINALVEHLTGNAHLLSQVAELSWFQLYMHRNKTEGNIAKATTDLADCLQAHISTAAWQSEAKHDWKVDIDHLLDIVVQDSEERRKQNDQLQKSGKSAFGDLQATINSMCAMLKDIQQAVNPTRPSAPVAIAYSDTIEINRSGSYSMPPSASTEVAQPLIRIDNEWEREALEEMLRETLEMGYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J303</accession>
    <name>A0A1E3J303_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031220.1">
        <property type="nucleotide sequence ID" value="XM_019176745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J303"/>
    <dbReference type="GeneID" id="30193841"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="82" mass="8957" checksum="528E9D36B09CF977" modified="2017-01-18" version="1">MAAAELVPDMITDVFNRLVNSCHTKCISSNPLNHRYAEGDLLKGESVCIDRCTSKFFEVNKQVGERMSAMGNAAQASGSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J363</accession>
    <name>A0A1E3J363_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031280.1">
        <property type="nucleotide sequence ID" value="XM_019176805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J363"/>
    <dbReference type="GeneID" id="30193906"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="362" mass="39739" checksum="1B9AC0FCA21AAB25" modified="2017-01-18" version="1">MVRISIPTLPPAPLVPPNALTLLPPALAASHLARFLDKGKGQTVILTGAGVSVDSGIRAYRGKEGSYSNPNYKPILYHELVEDTDRGNMFRRRYWARSFLGYPPVRDAMPNPTHIYIAALQHLGLAPNLITQNVDNLHSKAYSLLDPSVSNPPILELHGTLAKVHCLKHRHEITRDVYQEHIAKMNPVWDEAAKEAERTGNQPRTNPDGDVDLRGANFSTFSVPPCPSCKAEGEHTSIVKPNVVFFGETIRPEVRDHSFDLITNSSSLLILGTSLATYSAFRLVKQAVDQGKPVLMISTGPSRADNLPGLEKMDRIAGDVLSVYMDSVLKDNRGKVFDDVKKVLHKGVIKAIPEVDGPRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J399</accession>
    <name>A0A1E3J399_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031320.1">
        <property type="nucleotide sequence ID" value="XM_019176845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J399"/>
    <dbReference type="GeneID" id="30193949"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="56418" checksum="0060D70B48466AAD" modified="2017-01-18" version="1">MDIEQFRKAGYAAIDAICDYYQNIQDLPVKSEVKPGYLLDKLPDEAPVKGEPFDQIAASFKSDVLPGITHWQSPNFYAYFPANSTFESMIADLYAASVSNPGFNWICSPASTELEQVVVDWAAKMFGLSPVFLSSSKIGGGVIQGSASEAALTAAMAARERALRHLTHGGKQGANGDIVVPDEVRQKYGQKLVMYGSTQTHSLGAKAAILLGLTFRAVPVSAEDDFALRGDALREAVEEDKKAGLVPFFVVGTVGTTSSGAVDRIAEIGQVLKENPTMFLHVDAAWAGVAYALPEHRAQLRLDEVNEHAGSFATNMHKWGLVTFDCTLLYVRDRHDLTQTFDVTPIFLRSKEADAGEVVDYRNWQIALGRRFRSLKMWFVLRSYGVEGFQAHLRRSISHCQALAEAIRASPNFELVTQPQLGLLTFRLVPATPSQTLTEVTLNKLNRAFYTELDHRNDIFLTQTALKSKEGSLVHCVRFAIGGVHTKVEDVLGTWNILEQVGEKKLKEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4F8</accession>
    <name>A0A1E3J4F8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_04357</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031404.1">
        <property type="nucleotide sequence ID" value="XM_019176476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4F8"/>
    <dbReference type="GeneID" id="30193570"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="156"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="309"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN95739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="809" mass="88430" checksum="6163BCEE4318999B" modified="2017-01-18" version="1">MPCAHLDTAIENLKPPSPSQQVHREECTLCFDGQDSSEGVLVCLACFNGGCFAQGRAHAQLHYKKTGHELGVVVKRTRRELKKRDSNEPPLKKLAISAPSDEELFSYSTSLYCFACSPSSGGQAVETENSKAEDLVRGVLKALSSAQQSEVKAWEEEIVACEHTLLLQQESLVAPGEVPKHCTSCDLGANLWLCLTCGLANCGRQQFGGVGGNGHALKHFKETGHMLGVKLGTITPEGNADIYCYACDDAKTDPLLSTHLATFGIPILSQSKTEKSMTELQLEHNLKFDFSMTDADGHALEPVFGQGLTGLKNLGNSCYMASVLQTLFALPDFRERFAKQERFKHFKECPNPLPATCLECQMLKLGDGLLSGRYSHVASAPPPSTGLEDVNQEAPKFQEGVRPAQFKALVGKGHEEFSTMRQQDSEEFLQYLITKLREESKRQGLQDIDPTRILSFAMEQRLECGKCKRVGLQTEPADLASLPVEAVEEGVGEDGKKLFKRVELTKCLEGLCAVEEVPGYECSNCKEKTTAYKSSKFKTFPDLLVLHMRKFQLVNWLPTKLEIPVNVPSDLTLEHLLSQGLQAGEEALDMSAPSSGGNGGVPEFNATAMAQLEAMGFPTVRCQKALLATGNSDAEVAMGWLFEHMEDPDIDAPIEVTSSLSASQEGPSDEQIAMIVDMGFNHNQARKALRESGGNPERAIEWLFSNPDDPGEEASAAVAVEESTKEERVSGSATLPARYRLKAFISHKGPSIHSGHYVATIRQPQAGIEGHAEAEDEWVLFNDEKVVRAGPDGGQELRGLAYLYVYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4P0</accession>
    <name>A0A1E3J4P0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV damage endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031479.1">
        <property type="nucleotide sequence ID" value="XM_019176551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4P0"/>
    <dbReference type="GeneID" id="30193645"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="635" mass="71514" checksum="F9DDA0B4E9B89FD8" modified="2017-01-18" version="1">MSRRSARTALQPTAANLAPQSTSLPPAEPVKAEYPPKAAIMAALMTPEDDEELTPPPSSPVPQREEAVDEAAEKVVNKRKRAVKAKEPREEEQYEEESELEEKPKPKKRAIKKKAVKTEDEAEGGKPEGDKPKKKTPKKSRIAKDEPEYDEDGNEIVKKKRKPRVYPKKVYEIPDVERKTTHFKGRLGYACLNTVLRGTKPDSIFCSRTCRIASIEEEGMELPKGLAMMNVRDLKTLIQARSLGLFLWNEDNKIRFMRMSSEMFPFASHAKYGYDLAFAGEALKEAGDLAKQYGHRLTMHPGQFTQLGSPKKAVIDSSIRELEYQCEIMDRMGLDQDGVMIIHMGGVYGDKESTLARFKENFTTRLPENIRNRLVLENDEICYNVDDIFPLCEELSIPIIFDYHHDSIHPSSSPPSVLIPKIAELWKKRGIKMKQHLSEQRPGAVSVMERRAHSDRCQNLPEELPEDVDLMIEAKDKEQAVFELYRIYGLEDVFHDNLRPPDPSPSMHTKGRKSNLKKKVKETGEVDSQGEPIQLTEIEKEGDGGEGDDATLPAAEDPGMEVDGLEKEGEGDVRPKKKRAPKAKKEEAVEEKGEKPKANKKGTKVGADKTGDEGEKPPHKKRGRPKKNEAPVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4T1</accession>
    <name>A0A1E3J4T1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031512.1">
        <property type="nucleotide sequence ID" value="XM_019176584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4T1"/>
    <dbReference type="GeneID" id="30193678"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="15"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="236" mass="26068" checksum="6CDA632CD78D95A0" modified="2017-01-18" version="1">MPPPVTPPSPTQSVMDASSQISEEDHDAGVSSLMNRTEIGYLAHWSVSSHKYGFGVDNLRDGNDSTFWQSEGAQPHTIDLAFSRRVDISAIGLHMSHPRDDSYTPSKIGVRAGTGVHDLQEVRYMEFTQPDGWHLIPLRPMEMSGEGSEKEGPPIPCHFLRIVIFANHLNGKDTHVRGLRVFGPPGSKETTHQEPLPAGLVGNGDDPDEGKMLLQLGHDGLSDFTSVEFRMHERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J679</accession>
    <name>A0A1E3J679_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031614.1">
        <property type="nucleotide sequence ID" value="XM_019176204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J679"/>
    <dbReference type="GeneID" id="30193295"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="412" mass="45342" checksum="3FEDD767D63F9853" modified="2017-01-18" version="1">MSLRRNTAAALRAAPLLRAAPLISTRNVNDLTVTSPPNSSASVRPAIRHGPPTGGRSSDSGSTVTVFGSTGFLARYLIQKLARQGTQVIVPYRDEDEKRRLRPCGDLGQIVPLEWDARRPEQTAECIKHSDVVYNLVGRDHETRNYSYHDVNVSVAESIAQISADLGTPRLVHVSHLNANPDSPSEFYRTKFAGERAVRDAFPEATIVRPSQMFGHEDWLLNQIARYPIFSKLNGGQTRLFPAHVIDVAEALNRMLNAPVTSTASTFALPGPELYTWAELERLVSTLVLQPASTAPTLPKPVALLLAKLVNRGLWWPTTSPDEIERMYIDDAGADSFQIKASGPAGWNTPSGIDMVGVDGEPVKSWADLDIEPDTIAEHAIKPLRRYRSAATYDLPVENHIIKAPKQYHVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6E6</accession>
    <name>A0A1E3J6E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MYO2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031674.1">
        <property type="nucleotide sequence ID" value="XM_019176264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193355"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="89"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN96428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1614" mass="181659" checksum="0B90AD020A932603" modified="2017-01-18" version="1">MAVPYTQGTLVWMPDGTGGWRTGTVTSSTISSSDPPVAYITISSDSDPDVTTTIQTPLSALQNANADRTQADFQQSSDLPPLRNPPALEMVEDLAALSNLNEPSVLHAIATRYLQHMPYTYSGIVLLSVNPFTPLNIYDGTFINLYLGQKKEEQDPHVFAIAEEALNDMRRGTGEGGVDLSGAGDQTVIVSGESGAGKTVAAKYIMRYFASAHMGTNDPLLPRKSGHGEEGMSEIEKQILASNPIMEAFGNAKTTRNDNSSRFGKYIQVLFSHDHQIVGARVRTYLLERSRLTYQPPSERNYHVFYQLIAGAPAKERKDLSLPDSPFKFAYLSGGGTSSYLIHGVDDAQEFDTTQRALSMVGISMERQWHIFKLLAALLHLGDVKISQSRSDAHVVDDDSALILTSDLMGLPLPDFKRWIVKKQLITRNEKIITNLTCNQAIVVRDSVAKFIYSCLFQWLVSVVNASLAGDVTNDIGPTKKFIGVLDIYGFEHFAKNSFEQFCINWANEKLQQQFNAHVFKLEQEEYVREEIDWTFIDFTDNQACIDVIEGRMGILALLDEESRLPSGSDQSFANKIHHEFAKTEHQKVLKKPRFNSNAFTVAHYAHDVTYDTEGFVEKNRDTVPDEHLHLLQSSTNEFVREMVFTATEAAVGGQQAKTVESSTAKRGTPRKPTLGSMFKASLVDLMATINDTNVHYIRCIKPNEKKAAWEFDSAQVLSQLRACGVLETIRISCAGFPSRWTYTQFADRYHIMLHTNQWHSKMDVKELCRLILEKTLENEDDYQLGLSKIFFRSGILAFLESRRAATQFQLAATLQKHIRRYLARRQYANWRKSAVSIQAWWRGTATRRGLEIQKQETAALLLQTIVRCALATNRLKHARKAVIDLQSALRRFSAKRKREQMQAEKSAVFVQRLCRGALVAGRYRQTLCGVILLQSLWRRRLAIRELASLKREAKSAKKFKEISYQLENKVVELTQTLQKRNAEHKEICARLKGLEDDHKTVTHKNESLSARNHALEEQMASLTVPKEQFDDLAKEKKDLEVRLDELVLRSGALDTQLQEATRQLESTSKRSPVQLGSKTEDANTISQLRAELKHVREQLSRNDTFNALTGRAHPNTSTSPRSFNLRQLDNVSSAPSLHGISDHRRRNRRHSMVSKLHAATDGDAEDKPLVNTRALSAAYTPDVIQRSRDSQGLPVLFTPGNVHQHIVRLLEDLPSLDNEVLQGLIYQLKIPSPSLHTPLTAKEILFPAHLISLITNEMWKLAMVTESETFLANVMQAIQEHVLAFKGEDAICPGVFWLSNVQEILSFVCIAEDDASKGIAPEGSALNDDKLNWDDYTRLIGVVKHDLDSLEYNIYHTLMLESKKKLSKMVIPAVIESQSLPGFVTSDGSGRMLSRMLGGISGVGAPQPVSSMDDILNLLNRVWKCLKSYFMEESVMHQVVTELLKLIGQISFNDLVMRRNFSSWKRAMQIQYNITRIEGDFVEWCKSHDMPEGLLQLEHLMQATKLLQLKKATLGDIDILFDVCWILSPTQVQKLISQYHTADYEVPLNSEILRAVAARVKPEDKSDQLLLAPEADEVGPYQLPPPRDIVGLETYVPAFLNVPNIRQLATFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6J4</accession>
    <name>A0A1E3J6J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031726.1">
        <property type="nucleotide sequence ID" value="XM_019176316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6J4"/>
    <dbReference type="GeneID" id="30193407"/>
    <dbReference type="OrthoDB" id="2596929at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="767" mass="79388" checksum="6A2594E3C966D4B3" modified="2017-01-18" version="1">MADSALAHILRRSRLRALTAKAGHALHLDSRHAHPAPETLEKKEVIQALDERFYASLNEYSPEQLSSMAAAGSTVAAGTSTAKTSTTQRQAAQAATAKTTVSRVSSAAAAASTVHASTSTRSVAQSSVAHTSSAASSSIASSAVRSVAASSSSSASSSVAPSTSSTSTSSIARSTSRAASSTSTTHSTSSTSTTHFTSKAASTTAREITSHAAVQSSSSSAGSSPITLSSISATAAALSSNSDSSSSLSTGAVVGIVFAVVCGVVVVGSFFGWLYRKYTARSYNSSSPWSKIDDDITPYNSEKPGFDDVYGGSTVPVIASSRDLSRARSDMVPYTMYDNSPLSNHAGVGAGALAYGGQGDISPPPTALSYGIDSQGRPYNPHAGRTPMLHTLEDRYGHQAEPYSPYSHQPYSSASDNSRQLVGPGSYGPTSPVNRYGAPGGHVEMPLPSPVPLGGPAHASDADLRDLDEFADDPQMAGLAYTYGDSPTASTFVAHTQAPIKHDLPAETYRASDHTSTAPAAPDFPAPAVSTLDPTVPAASSSGEKSRLAPLPLPAFEPLSPLMSHFDTNNKGQSRQLAMYEDEQEREQRRMYQEVAKSAGIDEPVTPFVSYTNASPSPEPMPVPNAQALNQSTASTTSSFSTGMPRLPEIGLSAPRPYEHGQPLSPLTEVPTPMSSSSIGVPLPNPFDNPAFTSPKSAPSAPAPPYSPYEYEQEPGTPTSTTATSNTPVPGQTINRSFPPPDMPGSVLGSPAAGRRWSGSEDVYGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6M4</accession>
    <name>A0A1E3J6M4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031411.1">
        <property type="nucleotide sequence ID" value="XM_019176483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6M4"/>
    <dbReference type="GeneID" id="30193577"/>
    <dbReference type="OrthoDB" id="10341137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="368" mass="41847" checksum="B5407AF3894ED712" modified="2017-01-18" version="1">MPRRRSTTQHSRPDDRHNGHRHHRSSRHKHENRTGHLSRGTTGEVQEDQLDIEGSLHGHSPTRSLPESSRNEVPPTSSWEVPGEPRRRRRRKSEPQDGIWPTLCSLCLTIGIPLIIEGFAKSRRRHRTTSTRYRGRSEEPKETTHFRAQEHDDFEPEPDARVQDWVEQRAEEMEEIPVEAPPDTLPSVPDPSQEIDVGEEIPADTDLPPNDDCEAAGATSSSISTYYHVFTLSMTAERLASLGGRSGSRKSQHESSRPRGWNKIVKVPDTYDSLPLDKWMSSVGWSWKDPEAEGWTPEDSVPEELRLGKIDKSRTLRGLSRQDIDDVKSKVWTGYVRFYQDVIRAKPPVHLASEGQEEDVAEEAGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Z5</accession>
    <name>A0A1E3J6Z5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031376.1">
        <property type="nucleotide sequence ID" value="XM_019176448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Z5"/>
    <dbReference type="GeneID" id="30193542"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="58"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="477" mass="50780" checksum="A1D8D85C8F758BE8" modified="2017-01-18" version="1">MGSDVEMYGKNTSGNSSVEATAFPVSSNPDKSPEFDDPERDAVFGARKEGEVDYRSVGMLKSIVLMVKLTIALGVLAMPQVLLEVGAVPGVIIIIVISSLTTWSGRVIGVFKANHPEVYSLDGVGYVLAGNWGREVHSFAYALFMICLCGSGFITTSLAFNAITGHAACTVVWAVVAAVVTFAFASLQTLNTVSILGWIGFFSILSAILIITVAVGVEDRPEAAPSTGPWDKDIHAFNSEASFLGGMGAVSTTVFAYCGTPAFFNVIGEMRQPKRFNQALFASQGLCTALYITIGVVVYYYCGQYISNPALGSAGIIIKKVSYGIALPGLFVGCILYTHVGAKMLFVRLLRGSDHLTGTSFIHWSVWLGTVGMSVAIAFILAESIPFFGDFVSLVGATLGTFLCLITPALMWLHDNWALRKERTSIGFRSHIALSVFILLAGVFIVITGTWSSVLSIKDSYADGSVGSAFSCADNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J910</accession>
    <name>A0A1E3J910_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromatin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031657.1">
        <property type="nucleotide sequence ID" value="XM_019176247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J910"/>
    <dbReference type="GeneID" id="30193338"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="38078" checksum="17F29DA24E7C5D3E" modified="2017-01-18" version="1">MVLDRTPPSPGPYSCAATIRAHERAITALRFAPDASLLLSAGADGWLHFWQHVRGFKAHRSGINDISISPDSLYLATASDDHTSDIHLLHPTSGYVSHTKPRAIRHLAAHSAPILSVAFSPKSNLLATGSFDESVIIWDVSRGLALRQLPAHADAVWCVAWDPEGGMVLTGSADGLIRLWDASTGQCLKTLDNDTNSPVSHAAFAPSASYLYAATLSSTLRIYNIHTGKVIKSFRAPAAFVSEKFPCPTLIFEGPKPLKESEADKMEVDEKPQKAGQSRKERESNAWIMTGSENGKIIIWNVQTKAIVQVIEGYTSHQSSVLALAVSPDGRTIASGSLEYERSIKIWKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J943</accession>
    <name>A0A1E3J943_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031969.1">
        <property type="nucleotide sequence ID" value="XM_019176056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J943"/>
    <dbReference type="GeneID" id="30193143"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57560" checksum="A0CA08BE4034091A" modified="2017-01-18" version="1">MFSITSIKTSLRQQAGRAQRATFFKSVQTQVAPSAIERKHRKEREEGDISSVFSSLSGEEEKTLPPRFSELKRSVIGDEANQQRLVASWGRLTQHLARVAHEIESGQQDCIPETTYDEFINHRTPVLEQRIKTCGSVIIRDVVDEQTALNWLADLKSYIDLNPSVKGFPENDKQVFELYWSRSQLSARSHPRAMAVQRALLGLFSHTPADLVSLHTPITYADRLRIRHPGDAQFALGPHADGGSVERWEDETYRRVYHSILEGRWEEFDSWTIGERAQARQSMYDGPGSCGVFRAFQGWTSMSNTGPNEGTLQVYPLIKELSAYTMLRPLFRQQPRTDLDRDDYLAPANWELDLETSRFPGSPLARGQEYNDTTHPHLELDRTMIAIPRVKPGDQAWWHGGEFDNSKDAIHAVEKVHNGKGPSAVMYIPAVPLTLQNAAYVNDQKQTFLKGKPGPDFPGGVGESNFEGRGQVEDIESLEGRRAMGLEPFDVSGSLASGEREVRKQANTIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBV4</accession>
    <name>A0A1E3JBV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032184.1">
        <property type="nucleotide sequence ID" value="XM_019175694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBV4"/>
    <dbReference type="GeneID" id="30192779"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="9">
        <location>
            <begin position="683"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="518"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="764" mass="85268" checksum="B7F6644F4B847C21" modified="2017-01-18" version="1">MFATPPPTAIASKEEGHATPTTRLPTRSSSSILPPDNTCIRVPESTPIQVDGLSFTLSSPLVSYQFHVGDDGDLIHDYFGPYTPDLVRELPASRNGWRGPLARSRREFPDQGRGDFRLPAFHIRHDSGHTVSQFVYESYQVLEGKPPLEGLPATWGDTSSVSTLLIHLVDRPSYLRATLSYSIFPDIGAITRSFELKNIGDENVVLERAMSWSVDMPAAEWEMVQLSGDWAREGKAIRRPVYPGVQGFQSATGYASHFHNPFLALVRPESTETTGSAYGFNLIYSGSHATEVEQFTPGFTRVLMGLNPLHLSWTLAPGKTFTAPECAAVYSEEGLGGMSRAFHRLYRGHLIRSPWVDKPRPVLINNWEATYFDFTAGDIQAIAKTAVDLGVKLFVLDDGWFGNGQTHARVNDEQGLGDWEPNAQRFPDGLSKFVDSITALKTTAHDIMRFGIWVEPEMVNPHSALYENHSDWVLSTPGYPQTEQRSQLVLNVGLPEVQEYIISFMTKLLDSAQITYVKWDNNRGMHEMPHPSSAHQYILGLYHILDVLTSRFPDVLWEGCASGGGRFDAGLMYYWPQSWTSDDTDAYERLFIQFGTTLPYPASTMGAHVSTVPNHQLGRTTPLEFRAHVAMMGGSFGFELDLGTLDDKEKGEVRELIKLAERVNPLVVQGVMYKLALPETSNWPAALFVSQDRSQAVLIAFQVRSTISLVVPPLKMQGLEEEALYRVDGERYQGSTLIKAGLRVNWKKGSKGDYASKVIWLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC13</accession>
    <name>A0A1E3JC13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032053.1">
        <property type="nucleotide sequence ID" value="XM_019176140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC13"/>
    <dbReference type="GeneID" id="30193228"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN97451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40298" checksum="84404A5BE587B6E0" modified="2017-01-18" version="1">MSPLSPIAPPILPFGSPQPQQLFGVPFGAPPAIAGIDQIQRMRDQDTMHHLMVEPTHSKYIHSHLAKVHASGRRSAVLDIGSGTGKSHTFPGQDHLIPAQLTSASSSTTTFPLALINQSQYAVLRFPRPRHSRMWNQAGSWATALANTEPFADVVAIAADWKPFVRQRIIHGNLDVSTVDINQHLPYPSGSFDIIQVKSLARSHRQYPILVERLIRLLRRGGLLILVESHTCYENPTGMGLPTCLRTWDASVRSALAAQGYDARMASKLPFLVRGAGVFGNTAFVQEIGIPTTSYPQQGINNIAQAGALHARTLPAEMSSFMPLLRQHGYDERAIQAMIDECLHCLLNPQARFLQRLVAVYAFKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC29</accession>
    <name>A0A1E3JC29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-methionine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032302.1">
        <property type="nucleotide sequence ID" value="XM_019175812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC29"/>
    <dbReference type="GeneID" id="30192897"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN98440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="59972" checksum="B46C4DD8A47CD097" modified="2017-01-18" version="1">MAAFYQPLSQSSDPSRGRSDTVSSLGGFEFQHDLLPLTLSGEDGTAHLVEEKHVELWHGVALVVGAQVGSGIFSSPGVVVQEVGSVGASLMVWVVSGVLAWTGASSYAELGCAIPVSGGSQAYLAYAFGPMVSYLFTWTAVSVLKPGSAAVIALIFGEYMSRLFSHILSTETPEWAITLTAVFAVLICSLLNAVSPTMGTNSAVVLTFIKICTLVFVAVLGVIALVKDGPGEGLKPSKVFDGTVGDPGNWAIALYSGLWAFDGWDSCCYVAGEMRDTNRDLPRALHSSMATVLTLFVSANLAYFVVLDPSVVASSNTVALDFGKASIGKFGAVVFTTLVAISCFGALNGGLYTTAKLIYAASREHFLPSIFSRLHPNRRTPDHAILLNSSLTVLFIIFGGGFRVLLNFLSVSGWTFYLLTVLGLLMLRVKEPHLARPYKTWLITPMVFCLVAAFLLLMPIFAAPWEAFAAVVFIGSGVPMYYLTARLRAQGDRGYAGETGWNAIQATFTDAWSSFRYDIDGLLSKRWERSQIERLDDTGDEQQGMLREEVEMAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC61</accession>
    <name>A0A1E3JC61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032325.1">
        <property type="nucleotide sequence ID" value="XM_019175835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC61"/>
    <dbReference type="GeneID" id="30192921"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="445" mass="48450" checksum="FD640B00903AAD56" modified="2017-01-18" version="1">MVRTYNFLAPSLHNNTLLDVSFNEPSINIAGVSSPGDPVVRRFPVKYGDHKPLTGVKRMVDVGDNRIVVADDTFQVSTIQLSPADAEEPEHPTILFQETVKARSKDIWAGLVPVENGTVSALKSGHLTFHPFASESPSSSRSVPSPLACLASTPLAPTQFALGGKEVDVSIYDVERTFASSSDTDMSDPKRKNNALLPGQTWQAKNMPNNYLKLRPPVYHLALSWLDSPDALVSGTKMGTIRRFDTRQRKPVDDWKVSREGGIASLTTGLEHEVFFADRSNYLGALDLRTGKVLYSYSSLTATPHHMLPIPTFDPSSFLPSATRRIGFASISSDASIRIHSATTPPSGAEKGNWGPEGKKGDIVGMVGGVGIGEAVWRGYGERKIVVKVNDGEEGEEGESEDEEEVWEGMDVYEDEGEGSDVVSDEESESESEEEAPKKKKRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC69</accession>
    <name>A0A1E3JC69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032137.1">
        <property type="nucleotide sequence ID" value="XM_019175647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC69"/>
    <dbReference type="GeneID" id="30192731"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="716"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="829"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116490" checksum="7387B343130CA25F" modified="2017-01-18" version="1">MRESNVTGPPQNRAVTVITSMIYDRRALDTNSPLALLNSLTALTSLTATSPRIREILTIDGGLERLLDILRESSLPKEAPVPQDLWGLNGPPTARVITMERANSLKHSLAFQCVVNVGVRGSENVRTRVVQSGTLDIVAQIIESWLKDHGISIHPGPLGSQAAVDAFATGVPVSGTDSLRRKEKREGRDERDRDRDRERERERDTGERGERGERGERSHRGRTVHHHHQQAEEPTPTATIGRGPPGVPLSTDSTPDPAAPQPRRPFGEPDTSLNDTDVDMADADVEGGESTDASMDADDLSIDVDMAVTEDALGSGFGASQPSTTPRAATTVLPMSIPSTSRQGRERDSHSGGVAESLSGDDAAPPAGIPRITSESNLVASNPGIRPPTLTIGGPSRLPHLAQDPTSTQSSPMATPPPRQDGEYVSSGASVRHGRRGTIIARQGNLAPRNDRERELTRGNESGQSDGGEDMDLPTATIAAGIAAVNAQAMENNGPIVPDEPGPPPNVEIVETTGAGQEELEGPDPEVIAAEQARLDMEAGAPPGQPGAAQTPRVAPTEAQTPRQAPGQDTVPAVEAQIIIANGAPRSFDNLGSYVGISSLLNPDGNRYSDDSILLALQLFAYLSKYPHLRSAFHHPRRPIHATFDYGDDWASLAERPGISENPDIFSLVERLTFRPSPSDPVMFKVPLEIQYWAGVTMRNSCRKDDARGGIRQCANMSCGRWEKYSREFAKCRRCRKAKYCSKECQSRAWQEGHRFWCSTGKDHDPALEGSSRYAPPQAGRGGDDDEDYQIGLQMGLSPEVVSRALAAARAAGIIPQRGQEFIEGDGPEGLTGPTTTGTVTPAGNTAATTAAVTPTRATTGPAVAPSPHAPRRHVEPGQQVPPRVAEAWARFQNVGTFLGIRSPTAPATAAVGNNDVASGASTPDVQIPEIFPRTRPQPPPALTPNTVQAIRSAANEQVQQEALAHRVEEALAAQSRATGGGLSAEDQEARRLRLEQALQRVQETQRLQAEAQRAGESVPVPHGTVGSSFQSAGRAREEEGDAVDVRSAVADSWLARQRSPHAAASGSSGERQRPLGNNQGSSRRHGRGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCY5</accession>
    <name>A0A1E3JCY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032407.1">
        <property type="nucleotide sequence ID" value="XM_019175917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCY5"/>
    <dbReference type="GeneID" id="30193004"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="877"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="931" mass="103317" checksum="E4DBE8A9BE70FC4C" modified="2017-01-18" version="1">MAPSQLAQLKSALSSAGLNRQSHSKKDKKAFKKGGARETDRQKKIDKLDEIRRNLNKFDERETKVKHDVGGRNLKGVTGRPSSSKQAGLEQRRKTLLPEHQLKDHRGTFHDRRFGENDPSMSIEDRMLERYTRERQRGQGKKGLFNLEDDEEDPFGGLDEGTALGGLTHGGRSVTDLPGDDFIAQGLGDDDDPDEDVAKGRIDKRQVSQVHFGGFEPADDSTDLPEKKKSKQEVMAEIIAKSKEHKHERQQQREMDDDLRDQLDDEMADLQKLLAEAPSAPDASHLNVNPRNRPPAATAPGAEAIDDGQYDQVVRSLAFEARAKPKDRTKSEEELAKEERDRLEQAESRRVRRMRGESVSDDEGAGEGSRKRKRENEKPDADDLEDDYVENDSLLGPGLTREQIEDMELSGEGSGSEGSQSDGGLEEDGSEEDDDLDDDLDGSDIAMEEAGSESESGSGDESGVLSSKQKARIPKLRRAPARIEEIPYTFKCPQSIEEFEDILAPLKDDALPIVVQRIQSLHHPSLAEGNKEKLQNFLGVLIDYILIFASEPSPTLRQVEALAPHITYLIKLNPMSAAGHFVNKLNVMQKNLARGLAQGNTRAQARTFPGLPELSLLRLVGTSWSTSDFSHPVVAPAVLLMGQYISQSRVRKLGDVASGLFVCSLLIQFEARSKRVLPEVVNFVASTILMLLPRKKASISVQTYPDISVPSLSLYIKESPSDSLTTPVNIVPIIGSTGSEDGAELELQKCSLLLVALRLVDKLASLYIGTPAFTELMAPVKQVLEGSRTSTLPDGLKGVHKETLKTLSRTVTNSLVSRRPLALQAHKPIPIASHTPKFEENYAIGHHYDPDVERNASAKLKALYKKEQKGAMRELRKDNKFLAGEKAREQKAKDEDYNARMRKQEGSITAERAEEKAMEREKARDKRKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JDU6</accession>
    <name>A0A1E3JDU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_03519</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032138.1">
        <property type="nucleotide sequence ID" value="XM_019175648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JDU6"/>
    <dbReference type="GeneID" id="30192732"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN98276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="44849" checksum="2A6A6BC036BB92A9" modified="2017-01-18" version="1">MSLSSKLNITDLDLKGERVLIRVDFNVPQDKEQNITNPARIVAALPTIKYAIENGAKSVILMSHLGRPDGSPNPKYSLKPVATKLSELLKKDVEFLPESVGEATKEAVLKGENGQVFLLENLRFHVEEEGKGKKGDEKIKADPENVKKFREQLTELGTVYINDAFGTAHRAHSSMVGVQLPKRAAGFLMKKELEYFAKVLEKPERPFLAILGGAKVADKIQLIENMLDQVDTLIICGGMSFTFKKTLNNVEIGTSLFDQPGSEKVHSLVEKAKKNGVKLVFPVDYITADDFNKDAKTGTATDESGIPADWMGLDAGPKSREIFAQTVAEAKTILWNGPAGVFEFPAFAGGSNALLEACVKAAKNGSTVIVGGGDTATLVAKAGKEDELSHVSTGGGASLELLEGKTLPGVAELSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEV5</accession>
    <name>A0A1E3JEV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin regulatory light chain cdc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032451.1">
        <property type="nucleotide sequence ID" value="XM_019175348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEV5"/>
    <dbReference type="GeneID" id="30192429"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="141" mass="15499" checksum="575B18D04EF4C2E3" modified="2017-01-18" version="1">MSGNNAEYREAFALFDKKGTGQVARESLGELLRSLGQNPTQADVAELEKSVGATFSYDEFLAILNRPDGWKPAGTADEFIKGFQVFDKAGNGFIGAGELRYVLTQLGEKMTDEEVDELLKGFPVQDGQINYHSFVRSILAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF01</accession>
    <name>A0A1E3JF01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032494.1">
        <property type="nucleotide sequence ID" value="XM_019175391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF01"/>
    <dbReference type="GeneID" id="30192472"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN99417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="35456" checksum="293940710004951A" modified="2017-01-18" version="1">MDIHPQTGPQTLFSFASAHPPVDPPTHFSTGSDAQLGGLTTAELALVPSQPLAEPAASSEPQYSHMAFYGYMSTAVPPEHAGKIRTGFAGFRNVSRSTLFGQDTWDLDLATHLKVTVGYRGWEGWRNRWVVNIGVDDRPRTDIFQHRLELAPSALSGPSKTPLDPLSPPLPTFTTLHLPLSSFVLIKKGVVSPQPVSMTLSQIRTVGFALLGRDRDDNAAAPGEPPAGKGVEGITLGGWGKGGVSEAEDDPELRQMLEEDRLLGPDASAGSSMTNPPKPRSNSGYHRASAATASAPVGDEAQDGVREGYYELSIKSVEAVKWDPELDEPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JG17</accession>
    <name>A0A1E3JG17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032662.1">
        <property type="nucleotide sequence ID" value="XM_019175559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JG17"/>
    <dbReference type="GeneID" id="30192642"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN99585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="423" mass="46442" checksum="FD387C3CF53A66CE" modified="2017-01-18" version="1">MAAVHPPAVQSYLQDASRYQAIDRILDRRGPWTDERFEGGSATKEFLRTQSKILVIGAGGLGCEILQNLALSGFNDIHVIDMDTIDISNLNRQFLFRESDVGKSKALCAAEFIMKRVPGCKVTPYHGKIQDHPTSYYATFDIVVAGLDSISARRWINATLVQMAQDDGELLKPLIDGGFKGQARVILPTVSSCYECSIDMLTPPTAFPICTIANTPRLPEHCIEWASVLEWPKKLDTDDPDDIEWLYKVASSRAAQFKIEGVTWALTQGVVKNIIPAIASTNAIIAASCCNEALKIATASAPFLNNYMMYVGNESVYTYTFEHEQRPDCPVCGGESLSAEVSKDATLETFMETLSQRQDLQISRPSVSFSNGKALFWPSPPDVYEATKGNLEKNLKDLLAGDDTVVVVDPALPVSASVTIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHI2</accession>
    <name>A0A1E3JHI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032458.1">
        <property type="nucleotide sequence ID" value="XM_019175355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHI2"/>
    <dbReference type="GeneID" id="30192436"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="162"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="248" mass="26651" checksum="4805B544755F264F" modified="2017-01-18" version="1">MSDTALIIVDVQNDFLPPSGSLAVPNGRAVLPVIEEMLGPEWEWGLVVASQDYHPPSHISFASSHPPHPPFSELELPKHDSRNATYTQTLWPDHCVQGTPGAEIEASLGEAFKKRGGVRLVRKGTDPRIEAYSAFEGEVLSESYPAPPDAEPPKRVPNGPSALTDFLRDSDIERTVIVGLATDYCVNQTAISSILSGFSTALLTPAMRGISPEGTAATLTALEGMGGAIIGRDGNGEGWQFQLHEWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIU8</accession>
    <name>A0A1E3JIU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_03127</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032992.1">
        <property type="nucleotide sequence ID" value="XM_019175260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIU8"/>
    <dbReference type="GeneID" id="30192340"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO00800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="424" mass="45397" checksum="DBB1A0D1DF240A7A" modified="2017-01-18" version="1">MSRLNKRHPDLLCCNFNQDFSCVAVGHKKGYTILNCDPFGKVHSKNDQGATGIVEMLFCTSLVALVGAADTLPNNSPRKLQIVNTKRQSTICELIFPTSVLAVKMNRKRLVVVLENEIYIYDISTMKLLHTIETGPNPNAVCALSSSSERSYLAYPSPAPSASSTPLSSTAVPPAPPAPTTGDVLLFDTISLTALNVIQAHKTPIASLALNSSGTMLATASDKGTVVRVFSVPDAKKLWQFRRGTQSAKIFSINLNLMSTLLAVSSDSSTIHIYRLANSRKNGEKAHSAEESVTDGARSPTPSETPSTSSPPLDPHNPASGSSATSSLRRRSYHIGKSFVGGVGGYLPKSMSEMWEPQRDFAFIKLRGNHGRTVVAMSGTVPQVMVISSEGLFQAYNIDLENGGECSLMKEFSLLGSEDSGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ11</accession>
    <name>A0A1E3JJ11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA-dihydrouridine synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033030.1">
        <property type="nucleotide sequence ID" value="XM_019175297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJ11"/>
    <dbReference type="GeneID" id="30192378"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="65"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="48769" checksum="F7C880BAE9C20143" modified="2017-01-18" version="1">MPGAMLTKKDLGNSSFTTSDPGLTTSPFPRDTRSEEQLVAEQMDLPVEVSREYENDIDYREKLVLAPMVRTGSLPMRLLSLYYGAGLVWSPEVVDKAIIGCERVVDPESGVITYHKGQGPIFTTHPIEKPYRKFVIFQIGSSDPALAVKAAQTVQQDVAGIDLNCGCPKPFSTHSGMGAALLSTPDLLLDILRALLTSIPLPISCKIRLLPTQPSTQLLVSRIIRTGIRNLTVHCRTRDMRPGVPAVWSRLADLVALGKKRGIPITCNGDGEGWSNWEAIRAQTGADSLMLARAAERNPSVFLPTGPRCNLTEVIPRLLAIAEYTKNPWGNTKFLLSQFKPSPPPISDMPKAERKRLSQVVAQCKSIDQAAAGLGLSLAKGTVIFASIVERIESIQSGTNVWEERRLAEEKGEVVDEPQGLEERAEVDGFEVGVGQAEDEEEMAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJJ1</accession>
    <name>A0A1E3JJJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032998.1">
        <property type="nucleotide sequence ID" value="XM_019175266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJJ1"/>
    <dbReference type="GeneID" id="30192346"/>
    <dbReference type="OrthoDB" id="2576242at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="725" mass="79409" checksum="F0F4DEB8C9A1C87D" modified="2017-01-18" version="1">MAQSAALASSEVAHHSQAQPSSQPAPPLEQSKGSPSGLHQPTMPGDMQTQQMPTPVGAYRQPDQRALHPHAQPQDGKAGYNQSPRESWRPSPQPANPNIASGSAHTPGDHDGESQVTASRLVPGDRHDRAESEAVTAKQDLSPGISPSQSPAHQEPSLDSLAKLRQFKREVEASRQTKLSSAELDPSRLAKMAESFLLSQNQPTSQRKSPLSHSSTTSPFIPLAQNGSATATEDDEKEKFIKEQQLKEQLRARADRAGVAGKPKEQSPSTNQQQLPSRRPRAEDLIDPGTEFAATAPIPTRPAALSHDPVDPRLRGPPPGGPALSHPLPPHPIPNGPPALHNLPPTTSAPAPGNNYEPSARNFVPARFRDGKGGVPVFGAFKKYGSDNDSPVYPRVDSVPPPIREERHRPRDIELSPPPRSEGRSLADRISAPRSAAASSRPRSPSPVRGPAPYRPPRNTYLGPPAARDARDNREYHRLSSPRRYADRSPPPPIDAPHRPPYDTRYGDPRNYPDPRDSRDPRNAPERFRDREYARPLSRDFDRPPSPPGRGREFSRYPERDPYTGPPLDYRPAPPVPAVNENVLETIENLKAQLSHLQQAALKPAPSPYPPRDHDRERLPDTVLLHGTTLPRCGTILHHHPEVLIAIPPLPTVEGLRRHPCEGARLLLLSDEVRLLRFPVEETFLHRQAPDCDDQVRPHLPPAGATSLRGNTGTIDLSPRQRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKU5</accession>
    <name>A0A1E3JKU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032754.1">
        <property type="nucleotide sequence ID" value="XM_019175022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKU5"/>
    <dbReference type="GeneID" id="30192094"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="333" mass="35860" checksum="BE9FF216CC8EC4EF" modified="2017-01-18" version="1">MSTPTTCQTCSSTLPSPLPQSTHLPPCCNHPICLACTARNPRLREYVPCLKCGTGSSTLSGGVSVEAGGRRDRARDREEVGGGGGGDLLFAMGDEDDDGPGSAGIAGDLPPGYDEIDALPSLPPSKTPDSRVPPPHITPEPTKTEEEPMEIVEVTHLVSRGDTVMSVARKYAADPHDILEFNALPSTALTSNARILQTRKSIIISRRSVPSSSLPPLSYRDKQLEAAVNKAESENRRKERQIQRFRAVTKAADPDIANAYLSVEQLEEGKDVDYGTGEALEGGGKKAPMPSEGNREARALDRFWEDEEWESSSGRAERKKVGKWKVVGSSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKZ6</accession>
    <name>A0A1E3JKZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032794.1">
        <property type="nucleotide sequence ID" value="XM_019175062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKZ6"/>
    <dbReference type="GeneID" id="30192135"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="250" mass="27397" checksum="4E32BFE2FBBDE7DA" modified="2017-01-18" version="1">MLFSISITSDVICPFCLIGVKQLLGAIDEFKSTHPDAKFDLRLLPFELTPGLSEEPKPKRAMYEAKFGKERSDAILAMLPEKYAAVGETVDLDGQISSTHHAHRLQTLALCRAPEAQLPLAMEIFRGYHSNGKHPSDKAWLASLAVKHGIFPTEGEAREYLDSNKCDKEVRKAYDVARETGVTGVPYFVFQGKFALSGAIGQENFLQTLEEVARRETVLEKNSAPAINSAHGESCTDHCEGDSCAVPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLZ5</accession>
    <name>A0A1E3JLZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033143.1">
        <property type="nucleotide sequence ID" value="XM_019174764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLZ5"/>
    <dbReference type="GeneID" id="30191833"/>
    <dbReference type="OrthoDB" id="2576523at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="69936" checksum="077657D363837115" modified="2017-01-18" version="1">MSRHAHFTPSTYSSDSGHNGNANHHCDSHNRPAYHTNPTPVFYDNPEGGFLKRDSHRQPHYPSAHDPHSTQVYYDNPQGGFITPHSTLPPPNNAHMYTTNYIPLLGHAHPRPHPYTPSQPLQDLGFGPTPLFGWGFPQDNHSGQYPPEYYQQHQSHPPQSPYAQTKQQYPEQAHQAPYYAQQQSPPPPPLPPHPPQGQGYYPPLENLPPSSPPPNHVPPADPQGLYHYPQSNDPAASKNGHQNVDVQGHAPAVYSQPMPPDVHHPSVPPPPHHPGHVPPQHYSDDGMRLQYHYHHHPRDPYDPWQGAPPPPPPPAPVPPSSPPQQQQQKGRANEREERQYKQVKRYKEPKEKELPQTIQIITQGGQDASSSSSSSSNKMADQMQMMMMNQMMMQQMQAGQQQAAQMAAMTHQSMQNIQNSAANQGNNNNNNNNNNRGDDYGYGEEREGRRMREKRPKISVHSVQHKTKRSRPKTKIIHASPPPADDPKIVIVPQAAPPPQTVLLSTVYAENGFIDPKEGNGTMLTYTLWTTPANLGEPLNIIISNRSSPRVLAETMFEGGLYNYLEAAGFGGECMGLHMGDAQQVNLGDGDKNPKRLLARLVLELTEHNKKRNEVYSGINTSMTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG6</accession>
    <name>A0A1E3JMG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033321.1">
        <property type="nucleotide sequence ID" value="XM_019174942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG6"/>
    <dbReference type="GeneID" id="30192013"/>
    <dbReference type="OrthoDB" id="2597019at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130452" evidence="3">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="537" mass="57457" checksum="408635C313912FF6" modified="2017-01-18" version="1">MPMPLASLLPLLLIDSAFALPADSSSETVQASASTGASSASSESSTSTDCDYDGNVGDYLSCAKSKISTTALIGAGIGVTLGVFVLAFGCIWITRKKRKKVTDDRDQDADEGEESGIDSEKVSKRRRARQRNREESEAEDDWRPIKLREDEPPTYQEARRNHGKKGGSHCDNNTDSSSSELDPLPRKGGPRKGSRDTIYSQRAVRPAPSVAQPSLQAPFGNSGSPGQEAIMSGRQLYPSNPSPDPRHLQPRQHQQPPTNAARDSVFSTYSTRPPARGPQPALPSMTTARASVSSSFTSRQPSRGPQPPFPSAMRSSVHSRAPLRGAAGSRPTSTVSFSKEQPSTLDVPPMPALRGQTSAPRRDRPPTRLLRSEPHTPAPLQAPLVQAPALPSSLLTSNPANLTAPLNIRKSVVPSNYIPSYYQSSSNRPESAETSSLPFLSDKSDESPPDPSMKPVPVEMLSPSSDKSTLNSARLENNMNARERLSSGSEESRMGPISTVSPFKGKTAPARLSGSTGARDGGQKPMSRRRSETGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMY2</accession>
    <name>A0A1E3JMY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033268.1">
        <property type="nucleotide sequence ID" value="XM_019174889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMY2"/>
    <dbReference type="GeneID" id="30191960"/>
    <dbReference type="OrthoDB" id="2425321at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="54451" checksum="168C77201C15E991" modified="2017-01-18" version="1">MLMMIAASDLSQYLACELRTGGVDHMGKTLPAPLIRDIESWVFRQRVSGKVFLSGSSDGWGSSTSKPPPFLPLLQDIARRLRRQSFSRPPQVHPSNPRSPTLFEEDELFEDEDEGVFGVKRMVIDYDARSSASETSGDESDHHDAPRLVAQHTGESVIERWRKWEETGGEMRPPEHEEYIQGYGRGDGGRKRNVSNVSAPSAGSVNVTPARRGSETKHSSPTMEELLKARGDDTLEVGDDGMGGATIKAVPPTASATSAPLTTGSVITPSSPYTTPMADTSSAPADTKSVTPTPDRPPGLSSLVEADGENDDTPEATPSKSQTSQPRQTSDGSSRYASLGRSDRRHPREHSQDDAADSDDPEEGEAETGRWESARRVTLRPTRAMTKSISALPVIPSVEAVESEANEEVRDAEKEVAVKGEVAIQVGKLVEKIKELEARLEVMSTSTPAPPASVDPLPVTIPAPVEPQTFLTRLGLGGGDGTLGYVFLIGLGAGVGVGAIAMRILRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMZ2</accession>
    <name>A0A1E3JMZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033278.1">
        <property type="nucleotide sequence ID" value="XM_019174899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMZ2"/>
    <dbReference type="GeneID" id="30191970"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="364" mass="39250" checksum="26D36046CF705B87" modified="2017-01-18" version="1">MGKSVFLTAVTGYIGGTVFQSILDSPNPPSKVTALIRDPAKVNTLTSLNIAKQKGVTVVPLIGSLEEHDKIRDAAADADVVIQSADADDHDATKAILEGLKIRRDKTGHRPLLIHTSGTGVLSDDARGEYPTDKIYTDLNPSPATRLGPELHSIAKIPETAIHRNVDLEIVKADAAGIIKSYIVLPSTVWGYGTGEVFDKGIAHPTSIQLPQLIEIAIKRGRVGVVGKGANIWNHVNIQDLGRLYGLIWEKATVERPTIGHGTSGYYFGVAGDYTLFGAASAIGQSLRSHKALPENAETTPSSFTEEEIQQYFKGSYYSGTNSRGAADRSKSIGWTPKYVDQAQFYQDIDEEVQRLGKVVKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA0</accession>
    <name>A0A1E3JRA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033452.1">
        <property type="nucleotide sequence ID" value="XM_019174400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA0"/>
    <dbReference type="GeneID" id="30191461"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000286">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="741" mass="81298" checksum="6E52EED55B284CB3" modified="2017-01-18" version="1">MDSAAPPGVPPATPSPAPLAPSPAPPTTAPTPLPIAPAPAASTSAPAPKRYQKKPKQKKIDGLLAYTTSFVPGTYNVKIPAGDYLQKERNVDVARQISVERAKREQEEEKAQREEAGIAQQNPLSHILIIHPGSRNLRIGLASSYYPREVPNCIARPTTAVNASGANPVPALGSRVKKTRSEGNKKRKREEVQSQDVSMNGGEEAPVDPVIEPIGYLRDYLRNRLVQERLTTDWRDTTRVKAANAKTKPELLPEHNDPYRVDWTEPEGKPFFIGNDALRLPENAGYTTRFPILHRTLNRRDWSSSQSLLDDISSILTTALLTELEIPPSKYPEYSVLFIVPDHGDRIYVQEMTHLILKVLGFKAIAVQQEAYCAIFGAGMSSACVVDIGAQQTSVTCVDEAVLQPETRIKLHYGGDDITSSLAHLLEQCSFPYRDLDLARAQDFLMMDNLKMKICTLEEHLVANTPWDFFVPRTEGLTQKWALRTFDENILAPLVFFDTRLIDFEEKKGQGSMRFWNTSDDKVSDEISSNYEEPTGTMRACTSHLLPAPVPIPTPATESISVSSTPAPPPITENPSPERSSTSGTPAPDVKPGTSSTPTPVLGSIPTMASLAPLPTLSARKVFEFSAQSPLDAAIAASIGMAGTENKMKSLSQSILLIGGSSNLKGLSAFIAERLPSLLRQKGGPGEVTIVPPPRGLNPKFVSWKGGSVMCHIESLQDMWIRRDEWEATGIRALKDRYMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRJ9</accession>
    <name>A0A1E3JRJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033541.1">
        <property type="nucleotide sequence ID" value="XM_019174489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRJ9"/>
    <dbReference type="GeneID" id="30191550"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="110"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="669" mass="72959" checksum="D75E401F033ED62D" modified="2017-01-18" version="1">MDPASPLPADFPRLPRHASADSFEPLFPPHSAASTAAFSASETTLHTPRSLFASHSTIDSLASTLVSERYSSPYDQLDAYNKLDPYDFGLDAPAPYVEKPPATPVPSSGIEAPIVLSLWRFWAVFGSLCIVVFLFALDQLIVATALPKITAEFDALSQMSWIASGYLQFMNIFPSKHVMVIAITLFEAGSLISGIATNIELLIFGRVLSGVGAAGVFGSGMVIIAELTPLSTRGKYLSGFGICFAVACVVGPLLGGTFADHLSWRWCFYINLPLGAVAVILIIIIQPAYPPLGMKHTYTGYSRSMITQVLRCDWAGVCLSTAWGTCLILGAEWGGVSKDWDDWRVITVWAFTAVLTPVFCYYEWYMKDRGFFRIRMFSRRTIGGAGIVGFFIFGCYMILVYYLSLTYQSVYHVSATGAGTRLLPLVLSLVLFLILSNIAISKLGRSKAIISIGPVFLIIASACFSTITYETPKMRLYGFQVLLGAGLGCCMQNIMLAVQNELREEPLLVSLGTGMTVFMGFAGRIIGLNTAQSVFENMIQRNLRHEIPGIPYATIQLIMNDASAVWTQVPDDERPMVLKAYAKTISQVFLITIPIAVFALVGAIWMKDERMVSKEEEEEVEAKAAVGAAGGDVERGQYASVKTKRSEGMGSTEKLLPTVTEESVPKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRR0</accession>
    <name>A0A1E3JRR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033605.1">
        <property type="nucleotide sequence ID" value="XM_019174553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRR0"/>
    <dbReference type="GeneID" id="30191615"/>
    <dbReference type="OrthoDB" id="3345619at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10320" checksum="53DC24265FC49130" modified="2017-01-18" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTGKSNHPPTIHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRZ5</accession>
    <name>A0A1E3JRZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033691.1">
        <property type="nucleotide sequence ID" value="XM_019174639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRZ5"/>
    <dbReference type="GeneID" id="30191704"/>
    <dbReference type="OrthoDB" id="10376966at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="438" mass="49638" checksum="15DD919F2571DAA7" modified="2017-01-18" version="1">MSTITPSSFAALTPVHHIILDELVVSDPLSVLTLSRLCYKRVIPVLYRTIHSSPEVFRGLELEQGYERTRDALASTKALSIGGSTSIDTLFELGGREYTRVCHSCAKNPSACCSSSGYISTIYPRRYFHLFRFLERVEIGFSALQASRTYYLKRDRPDLEIDLVGRIGFQTPADLKGTIFHLDEYGVDYWHQVDTHLLYLNSREAVILLKGEVPNSEELVVSSDGTRVGRASFGRIGEQLHTAWPNGERLRVFVGARQPWETLNDYELHEYTITMALALVGYAENLTSRIESRRGWELENDHCKDEDSEDDEEDNDGSGDKKDSGGDDDGKSDGNSEGGDESERSADESEGFDHYEIEESDEDDEGSEDDESDEDDAHEESKPLDRVEIHFPLFDQVFIHMPEEGRQVVDALVRDGRMVLEEFDVKAVKELGERRWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS04</accession>
    <name>A0A1E3JS04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033685.1">
        <property type="nucleotide sequence ID" value="XM_019174633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS04"/>
    <dbReference type="GeneID" id="30191698"/>
    <dbReference type="OrthoDB" id="10308667at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="505" mass="56195" checksum="91A150778E758377" modified="2017-01-18" version="1">MSSITPSNFAPLLPVHNLIFTELLASAPSSVIALCSSAYERAAPVLYTDIHSSPGVFRGLQEEKAYGRTIEALRHTKTLSVGGSESFETLYELAGPEPRGHCCPMCAPFRIVPTNPSNMSSPYSRVYNNLFPNLERLELGFGSLKASAYHYDCFDSVPSEEDPLFAGGSRDSIVRQVARLMPYNLKEIVFHLDEDEADYWYEVDSHLCNQRPREAIIFLKGTVKGQERDDNRPLCPESEAKRTTFGRLGERLPLEWDNGVRLRVFVETREPWESLNARELRGYIISMGMALVRYVLLDSHQRGRWYWDGSGVQVGHPVGSYDLDWSSDSDSDTESDDSDDSDVAGDSDDFEEPAHLSHSSHSEDSEDSEDSDGSDGSDESSDSGNSDDSEDEKGQVGLHFAQAIQSQDVQEHGDANAGGANDRAGNDHGRENGAGDERDGAVNEVDEEEQVFQIEIFLPLLHQVLAQMPANHRILVDAMVGEGRLVLREYDVKEVEKLGDLRLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTV9</accession>
    <name>A0A1E3JTV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033608.1">
        <property type="nucleotide sequence ID" value="XM_019174556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTV9"/>
    <dbReference type="GeneID" id="30191618"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="43828" checksum="DD058B78BA1FAC25" modified="2017-01-18" version="1">MAEIYQKKELLALMKEGANNKCIDCDAPSPQWASVSYGTFICLECSGVHRGFGVHISFVRSITMDKWSEAQVKKMKLGGNQKFKDFLESYGPEGGYTKGVGMSEKYNSWAAAQYRDKLAAECADPPQEWSPSAPPPSAPVRPESAQATRKSRAGGSLGPSRTNSPSVPQGYSDYNQPANNSRNDAQRAQNEAFFERMGNANASRPDDLPPSQGGRYAGFGSTPAPDPSSAHASYGTSSHSAPTLDEFQRNPIGALSKGWGLFSSAVALAGREVKTSVVDPGLARAQALAAGEGSEEWKRYFNDASVRAREAGGWIGTQAQTGWEGFNDVAKARGGVDFNEQFNKLGINKHDQGNQGYEGYGQVGEEPLSAKGGASGGYGQKNGGKVQEEEDFFDSWGVGESTGGKGKGKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWD7</accession>
    <name>A0A1E3JWD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033765.1">
        <property type="nucleotide sequence ID" value="XM_019173958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWD7"/>
    <dbReference type="GeneID" id="30191010"/>
    <dbReference type="OrthoDB" id="10435729at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="44998" checksum="9097696897F3075A" modified="2017-01-18" version="1">MPVIEIDKKGIIGDLLGGGDDSSTAQAQNTQAAKTAASSSTDKDATTSTTTKAGKTDSASSASDKANSTSADSKNEKASSSSSDNSSATSANTAASTNAKNAANSATSKTSDSSAASSTPSSTTSASSSETFAESTSSISGTATSTWSNQNASDSVSSSSDSAKSSTKASTTELGDNVSASLSSSSASSTASVAAVAANASANTGSSTIFNPDNKLFPLAMVLVSLAGLFVIVTTVVLFIRVFGWNKRRRTERWAIPSYIGSDPSFEPVEPKRFETITNNIASTNPGQHDNYNYVDYPTNASAVNEHPARPVRAQYVAASGPTPNPYDGYYDEKSQHLGSPVPSFNTQRGYDERPPTGVYDYGAQYQQPSVPQRSNTKSSAYSSSSGGSMGAQMMGQNPSQAGYARRYSGSGQSFKSVTSSRTGRSNGGRLEKGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWK6</accession>
    <name>A0A1E3JWK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033838.1">
        <property type="nucleotide sequence ID" value="XM_019174031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWK6"/>
    <dbReference type="GeneID" id="30191085"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="153"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="501" mass="56053" checksum="3A596CC1348502A4" modified="2017-01-18" version="1">MRPSPRNLSTLPPTIRSLLAARRAAPSTSSSSESPSQESQQIEVNGWIKSVRGHRNVSFVELNDGSTSESLQAVLKGKGKAEGLGVGTSLSLKGRLEKSKGKGQDLELVIDHAQVAGHCDAQLYPIQKKSLPPAVLRENAHLRFRTTQTAAVMRIRDALVRDWHDWFEENEFVHIQTPLLTASDCEGAGEVFTLKDHPAPTAPTSPQPFFYHPVHLTVSGQLHLEAPTHALSRTYTLSPAFRAEPSLTSRHLSEFYMMEGEVAWVESLDGLLDVVEDGVRSVVRETLGESKRGERLRRDLEAVSHSMQESEGDETTLEERLEDPLARLRHIVAQPFTRITYSSALELIATLHTKSPDVVSPAPPWGEGISTEHEKLLAEHYNGPLFVTRYPKSLKPFYMLPTSSSQSDQETVECFDLLFPSWGEMAGGSLREHRLDHLTRAISDAGMKPEEYEWYLDLRRYGTVPHGGWGMGWDRWVGWVTGLGNVRDVVPYPRWKGHCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWM7</accession>
    <name>A0A1E3JWM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033923.1">
        <property type="nucleotide sequence ID" value="XM_019174116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWM7"/>
    <dbReference type="GeneID" id="30191173"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO05268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="498" mass="55522" checksum="F9A779581625DB57" modified="2017-01-18" version="1">MASLSNEKVTELQQAGDFAIKSEEVAPKLDTTQWPLLLKNYDKLLVRSSHFTPIPSGVSPLKRELSTYVKSGVINLDKPSNPSSHEVVAWLKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVAVVRFHDKIADEKALPRALETLTGALFQRPPLISAVKRQLRVRTIYESKLIEFDNKRNLAVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGITGENDDIVSMHDVLDAQWLYDNTRDESYLRRVIRPLESLLTNFKRIVVKDSAVNAVCYGAKLMIPGLLRYEADIEVNEEVVLMTTKGEAIAIGIAQMSTVDLASCDHGVVAKVKRCIMNRDLYPRRWGLGPKAQEKKKMIKKGELDKYGKSIDGVTPKDWSKGYIDYNVDDAPVSGLLPTQPATTGDVKMESPVKAEGSAEGKRKREESETPAVVAESKEDEGKDKKKKKVKTEGGEEREETAEERAARKAAKKEKKAKKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWN8</accession>
    <name>A0A1E3JWN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_01971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033934.1">
        <property type="nucleotide sequence ID" value="XM_019174127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191184"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="395"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1406"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1442"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1478"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO05279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1732" mass="192723" checksum="0AB75547B432E00C" modified="2017-01-18" version="1">MDIAHSLHSEIDSLSFSFLSTEDVQAISVKKLDNPILLDNFNLPTRGGLYDPKLGPMSARDVCETCHLSFYACPGHYGHIELPVPVYHPLFMNQCYGLLRGVCLYCHHFKMPEVTLASYAARLRLLDAGLLTESHEVAAQFDNAVGKSARSKDKDAEEDIEGDVDMEEVAATQAPENVAEFLVRIEAYVQHHLKTAKHNAANKKRAEDAYKDGLVFEERKKLLHEFGKKIWNKCSRCHAYGNTFRKEKAIKIIEYDLTPKQKLSNKLANLRRPDVLASAGKYSSKQRRSDDAAEVDEGIEMESDKSNSSDEEGEDVASDAEEEGDNEDVAHKVAKTASGQVKGTRGRNERVMSPAEVRAHLRTLFKKEPQICKIIYGKHGSPSASASSSPAPLADMFFMSVLPVTPTRFRPAARMGDDLFENSQNSLLTAVMQTCQRIQKLNQGLIDQARAERGEIELDEVAKAQAPRTFELLLETLIKIQHDVNSFVDSTKNPAVMRQGKLPPPGIKQLLEKKEGLFRKHMMGKRVNYAARSVISPDINIETNEIGIPPVFAKKLTYPEPVTQQNVAELRQLVINGPKNHPGASLVQNEDGTQISLDRTTVAQRTAIANQLLTPQGDDHGLGGSAGPSKKNKKVYRHIRDGDIVILNRQPTLHKPSMMCHRVKVLLGEKTIRMHYANCNSYNADFDGDEMNIHFPQNEVARAEAMMIANTDNQYLGPTSGSPLRGLIQDHVVAGVWMCNKSSFFTREQYFQLIYGALRTENDYTGRSKIMTLPPAIFKPRPMWTGKQIMSTILLNLTPNNARGLNLTSRNKVQNKLWQRDDSSDPTMSEENVVFLDGHLICGVLDKSQYGASGYGLVHSVHELYGPYIANKLLGVLSRCLTKYLQHNAFSCRMDDLILTAEGEKIRKDILDKASGDGATAAMKYVGLPDNSKIEDPDTAKNLAIRLEEILRDDHLMAGLDAVMQSAFNKTTSKINNDVLPEHLVRPFPDNNMQMMTISGAKGSKVNASQISTLLGQQALEGRRVPTMVSGKTLPAFKAFDTSARAGGYVANRFLTGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGVKVHYDHTVRDSDSSVLQFLYGEDSLDVTKQTHLNKFDFAAANHTSLVQKVRPNDVSSKVNHEAPGLMKKALKKPHKYPPVLSEYSPSRYIGAMSEAYAKKLDSYIEDNKFGYISKKNDNNSSPFTSERVPEKEFMHLARARYMRSLVEPGEAVGLMASQGVGEPSTQMTLNTFHLAGHGAANVTLGIPRLREIVMTASAKPTTPTMKLPLRDQISDKDIETFVKQVSRLTLSEVVERVTVTERLSAKSGENDSRQRKYTVLLEFFPLKEYTSEYEITTEQLHESLAFNFAPKLKKEIQNEIRKVAKTKEQELQVGKGRKVRAGGEDGEDEEEREPEVRRRGRDDELDDDDEDSYQLKRTAQARQHEYEEDSDGGDSGVADLEDILENDLEGEDDEDVDEEGATEKAKQDSKADDLAELFKLGSKYATTFSFDNHGGKSAQFDLEFPANAPKLLLVDLIERTCRSAVVHEIENIGRCMKIFSDKGEFTRSLITEGSNLRGMWALADELVDLDKLSSNDIYAILTTFGVEAARKAIIDEVSSVFGAYGIAVDYRHLTIIADYMTHGGGYRPFNRTGIAAKSSPLLKASFETTVAFLSEATLHGDFDDLTSPAAKIVMGKPSSSGTGAFDIRAPTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWW9</accession>
    <name>A0A1E3JWW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033891.1">
        <property type="nucleotide sequence ID" value="XM_019174084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWW9"/>
    <dbReference type="GeneID" id="30191139"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="860" mass="88905" checksum="B43090BDBAE3F6A4" modified="2017-01-18" version="1">MTTAAAPAPVPPRAPTSLDPSPHGSSTSLGDNLALPNPAFIRRRGGDGSASPSARSSISSSQDLSTLTSEELWILNREDVPDMSNPHTTASERPLDTVRRQSKISEAAFHGGLPGEVIWPSAPPVDDFAPLPRAKSHTSINTPGKKRMSIRSKSRRTSDTPPINTKPNVKAGAQSMPVSPVAPNQAMMSSAHSSSTSLSSHQALSSSKSFPALNGKGGAAPPPTTYYSRDFLSSLAPREGGYAIAAQLGGGLGAAGTITATDNKRRSSYAEQGGRARAPMAKSTGMGRWSLDGGENYGRPYMTASASTTASNLSAPPPTSDPSNTSSIEAPRMPEGAMPAISTPHGAASVSPAPAQVQRASPNPSPLSQQTSAEEVIPPTPEAPVAPNAPQVTEAAVPATKEESALVSAPASAAAKVPPAPAVTEKRSKRQIAKDTKAAQKAEQQAAAQAAARAKAEQMRVELAKKQKAREDEQKRREDAKRQEKEEKARKKAEKKDKKNGVLRKTAASGDLKQKPAQVKATPVKAAPAQTVPGTTPSSVVSPAPTAATPARASSAIPSTPTTLRSAANVNTPESGVAESTRPSRSSMPAGRMLSSEQAGASLSSEKGPEVKLRRSFFGTLRKRLSSNVVEKGDCEASPVPPMPNGAAAQAQAQAQDDFISPPPRRTSLMAVNRGSSSKSQAPGSEAVAEESPVDSPSTVRPNVASALANAPSSPSPSPSRNSHQIPRKPVSPEGSINGRRSVSGPRPMPSDTSRSRATSLAALSTEQGELAAPVTPSTSGDDSQLSYMQSRSSHKSEVTPVTSLSGSEAMSEDGSRDKDNVGAPVLGEEVQPAEKQSGKDSDETLLPHQVTAVNAPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX03</accession>
    <name>A0A1E3JX03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033941.1">
        <property type="nucleotide sequence ID" value="XM_019174134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX03"/>
    <dbReference type="GeneID" id="30191191"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="51" mass="5657" checksum="F5234560CD7AC94A" modified="2017-01-18" version="1">MAGSLDNPRRHVQVLPERVGQVAGSEFPGHYPGEDHSWNLQAFKKARGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYZ1</accession>
    <name>A0A1E3JYZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034143.1">
        <property type="nucleotide sequence ID" value="XM_019173438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYZ1"/>
    <dbReference type="GeneID" id="30190485"/>
    <dbReference type="OrthoDB" id="2594386at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="407"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="710" mass="82457" checksum="D6D682C56A50BC17" modified="2017-01-18" version="1">MFNLTEGAPAQSHSSSTTRVTHHHTIEMTDDYFEGSDTILLFLDAVRGLPLSSQAQIRSKPDGEIVHALECLLQFAKKWDSDLTLAAYERVSLHEVTNCYWKDCQLTPIDIFALAALGGFSDVAAMMGSLTSEEIRNVTSWLEFQMQEANDYNQRPVEQVQLRELQELMQHLSDLRVDLIRCETRVSIANWDGWMLRLSQLYLDLNRTRKDFKYIHGLGNALVNGAALNDGTVALEDDLSDTSSEISEFSEDGVGEDGDDIEYEDDRPVELMFAQAAQDEAERARRPRRGAPRKPLDMKLFQTLWEDLETYEYIGARLGVDKRTVKNRLREMGLHRRKFSVISHRELSEKIDKISKGSMGAIGVIGVTGALRSEQIFVPRWRIRLCLKEVNPAAAALRWQFVVNRRRYYVPFINSLWHIDGHHKMFRWRIVIIGIIEGKSRKVVGLRAQNNNRAASVLDVFKKATEEHGVPSRVRADYGKELLDVKNYMIERRGDGRGSFIQGASTHNQRIERLWVDLQRWNTKKYVELFHQIEDEQEVPFHDVHLWCLHYTFLDQLQMECDAFLAAWNEHPLRTEKQLSPNLIWRRQSRRMREAYGEEWWQLDDDEDDYVRRHHDLGLEFNSYGVDAHRLWSANPGARERKKEKTVVEPVKSMSPYLRDILTNAAFLEWLDGEMPPPALYQEDFGRSRYDLCVARVRAVFERNDVDQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYZ9</accession>
    <name>A0A1E3JYZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034139.1">
        <property type="nucleotide sequence ID" value="XM_019173434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYZ9"/>
    <dbReference type="GeneID" id="30190481"/>
    <dbReference type="OrthoDB" id="10317984at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="776" mass="85831" checksum="0B101DC779AFBE69" modified="2017-01-18" version="1">MDPRSLYTQPSATPVPGNHQPSQTTPATADSSPHSHQTPRLVPSYFHIDQRVLPGSSWTRIHHDNTPAQSSHVAFTTQGSSIPARIGQSGVSTPHHSGSFASHHQAQTTIPNPTSTLVDEPALEPPYIGDTTDSRIGQSNLRPLAYHKSPPFSPAATSHGPDGTHSYQPPTYRYRPYSLRERGVVDKGRGRAVEKSDGVHSDEDERKSEEEDGPRYNYGYGGASQGRAVSTTEVSALIASAALSHMPIHDRAHRPAHSPSAETPTLPPMNTLHHNSIPRGSDLHCPQDAWSHGWHQNSSRDEPYESHGLHQSYGDLYSQSFYGNSYPYQTAAGSNTSSASYQATSRPYHDTPNQYDSRSPATNSLHFKTILAYQAVFSALVQECHYTAQTLHYTPFQEYMARAWDQYEAGGREDTGLLVDLFEKAVRGDAAEQAERAERAKQQLQPAGMGYEGDPWCRGYPVRADISGREAAYGPSYTDYQRSSTTSSKDDPITLLRQTPFRPNLNRSQTMDDTQAHRPRSPTPLRSRYSNLGPHPLEAEEDEQEQTGSKDTATSRRLKSLGRSKGRALSLGPMGTSLAPTPPPLTTAPKRRRTSLPHPSTSAPNPIKLLASQYPFRDRFNLALNKFHADGDSSPVYLGGVRVNTLEDALGGGRGAVGRWSVGEVERIARMAGMMLLDEDPDKDAEADDTSKIADDQLESKNAREKRKNAFRWFRKSLISVYVANGGKEVFDRWERQMQGVTGREKAVGGKWDAFTAEVEEMWGRVTRELAQRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ14</accession>
    <name>A0A1E3JZ14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034190.1">
        <property type="nucleotide sequence ID" value="XM_019173485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ14"/>
    <dbReference type="GeneID" id="30190534"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO06090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="89" mass="9865" checksum="310BF9A55845BC1D" modified="2017-01-18" version="1">MSSNGISPANLSRPHKTTMSELKLRRLKEHNTRLREDLARPRVRVSEASVSLIKHCSSTKDPILPSVWGPPGKNEDPYSPPEAGCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1X5</accession>
    <name>A0A1E3K1X5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034537.1">
        <property type="nucleotide sequence ID" value="XM_019173832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1X5"/>
    <dbReference type="GeneID" id="30190882"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.40:FF:000007">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="119"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="47779" checksum="C012B767BE9B718A" modified="2017-01-18" version="1">MPVTTRTSRSVVAHATEATNKANSRGAKPSPPKAPPAKRQKKETAPQPKVGTVPAPIKVVGSYTPALLPPVLNFDLQTAMSHLSRADPRFTQLFRHLPCRPFVNLEAVDPYKTLVTSIIGQQVSWMAARAINARFKALFGFTEENEGFPTPEMVIAQDIPTLRSVGLSQRKAEYVQSLADHFQTGRLSTDLLQNGTDEEISKALIDVRGIGQWTVDMFMIFSLRRPDVLAVGDLGVQKGLLKWALAAHGALERKPVTGATPKKKGKGKAAVKKEEVVDQVDVKGEGEVDTFVRDATPIRQPPSSSAPPTPITPGPSEPTHRAALHTPATPLDFKPSQIPPTPATPTAAPEEFAEVPPNTLPTPTTEEMLQAPIGHPEWEAHRAVSLPDGLGVDVLKSRLNGKKVKGGQYLTPQEMEALTESWKPYRSLPVFYMWPVAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Y0</accession>
    <name>A0A1E3K1Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beclin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034645.1">
        <property type="nucleotide sequence ID" value="XM_019172919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Y0"/>
    <dbReference type="GeneID" id="30189960"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="144"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="296"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="202"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="519" mass="56225" checksum="144B02438BADEEB4" modified="2017-01-18" version="1">MSDDGHHVCQRCSQVSAPPACPAHPQPLQLAPLSPAHYSLISSSLPDSPASSIDDWPPFEKLAALPPSSRQSAKVWADANLSTPGAGSSRHGGRSVAESFILLSDSALYPKPSPSPSIQNPPHASHLSAQLHSILSGNTPISHPLCTECTASLTAEFQKKAEELGKERDAYIGFEQGILRNREKLKSKVPSKAKPGLGGHDVEGTDAEWAALTRRKKELQDEEEQLKAILEGKEKELDVAEHEEELAKAEEEEVEREENDFLLSHSALSTHLSHLTSSLNTAQTSLLLSRTLLAHLESTNVYNDAFQIGHVPLSPSSSSNVTVGTINGLRLGGRPVVEWEEINAAWGLVALCLHRIADKVGCVFDTYKVVPLGSYSRIEELPPSKSSYELYASSDITPARILQNRRFNHAMMAFLDCLRQLIEFGKKEDKAWAMGNIEIHKDKISNHSIRLPGISSMPLGLPSMSIMGLGVGDTSAKDKSSASDATAEEAWTRACRTVLGVLKRILVMESEADRGAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K255</accession>
    <name>A0A1E3K255_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034731.1">
        <property type="nucleotide sequence ID" value="XM_019173005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K255"/>
    <dbReference type="GeneID" id="30190046"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10549" checksum="0D244BAADA4B0875" modified="2017-01-18" version="1">MVTAYSLKSSELRYTANTQLEQLHARYTGTGHADTTKYEWLTHQHRDTLASIVGHPALLGYLSVADGESQARERFELTEKMLQPCGKPPAKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2G3</accession>
    <name>A0A1E3K2G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034660.1">
        <property type="nucleotide sequence ID" value="XM_019172934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2G3"/>
    <dbReference type="GeneID" id="30189975"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="785" mass="87356" checksum="8273CB1A87278AC0" modified="2017-01-18" version="1">MPSRDPPKIPPIKLKLTLGSAPAPATPAPPPPVPTSHGSNGSVSTPLPKIKLSTGNVAGPSSLRINLPEPGGSDSPLPAPPGTASPAALMTPTQPQRQKTASTKKVGRPSTKKKATVAKRPSAIPPRLLATSSATPSRQMAPTMPETPTQDGTSTSPDVLSLPLSPSSQGLESGSPQQFEEETPSRRAVKWTRTKKPLKELLQKIMIELRKKDEYALFEEPVDTQAYPDYLERIGGEDKAMDMGTMQAKVDNNEYRSLDQVEADLRKLVEAAHKFNAEHTTPHKSASNILSHGLKHIERARPIAITPPPSPVRVSATPVCATSVVSTRDREQRETTVVQEERVRDHVPPLHYIPEEMLNFPPNSAMARAVGWNLNGGKRVYNKRISRAREKFSGKWRNWLVDGSRDIAEAEEIHQLFEPWRLRSGDQWREFIDWQAMRNKDGWWELEMAQPPPHSAAQQAPLPFNPATPRHDQVSHKTLSPWEYGQYPSVASEVAFLRQRIPSITDDDEILAEHIRPMYTRARRGDPPAPTNLVNVFDGPLKRSPGDWVRDLVTGDVVGEAYLDSLDRFVKGAMESVEGEETPDYPLDEYVFDHYHEPLLQSSTRKLVHDTLRDLSAPDTRASYSALGEAAYSRVALRYLTRPANPMDIQPLLREEGDFMYQGVGGKSGVNVGLEWTGKEMSRLLEKQRRLRGVNSSVGDKRKREVEDETEIKRVKTEDDAAVSKDTETRAEPSESEEVAAEELKQLRLELVALSKFYPLPALKKMSKEDAALLPVNVRGLMCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K361</accession>
    <name>A0A1E3K361_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034962.1">
        <property type="nucleotide sequence ID" value="XM_019173236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K361"/>
    <dbReference type="GeneID" id="30190277"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130744" description="UBC core domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14020" checksum="206693DAAFC2B44B" modified="2017-01-18" version="1">MLIRTIQVLTLKSTLISLQSLLCEPIPNDPQDAQVAKHYLSDRASFNDTAKHWAQAYAQAPVGKSQGGAAGSGKKASDAELAGLTEENVASFTDMGFPRDRVIQVLKSKNYRGNNVNPANYNTVSELRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Q8</accession>
    <name>A0A1E3K6Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035729.1">
        <property type="nucleotide sequence ID" value="XM_019172787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Q8"/>
    <dbReference type="GeneID" id="30189823"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="35"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="47739" checksum="4A45AC6C1FBB7FD4" modified="2017-01-18" version="1">MTELDSRLDAFLEGRKQKGRFRTLKEYDTSASSALVDFSSNDYLSLTSSPAFRALYLKRLATAESIFGSTGSRLLSGCSPSHSSLEIRLADFFNSPSALLFNSGWDANVSFFATVPQSSDWVVYDELVHASVHSGLRSSRVPVERRVPFSHNDPEAFAQVLIQVSSSSTSQTSTVFLALESLYSMDGDMSPLPALLDTMESYIPRSRMCVVVDEAHSTGVYGRQGRGVVHALEEGGWAAGDDRRRGKGRVDVRLMTFGKAVGCSGAVLLCSPTVRTFLINFARPFIFSTAMPHSTVIALQCVWDILQGGEGDERRNKLMGIARYLHSLLDDMLATTSPRLLCLPPDPVVPFSSSLSELPADPPTPILGLLTPTPHALAAFLLERGFIVRPVVPPTVPPGGERVRICLRADLGKDVVHRLVQALREWVDRQAPSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6U1</accession>
    <name>A0A1E3K6U1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035492.1">
        <property type="nucleotide sequence ID" value="XM_019172550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189582"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="658"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1148"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1323" mass="147344" checksum="A538BFE3B2FB5796" modified="2017-01-18" version="1">MAAITPIPSGDNLGEPNGTATQPQPDFAQSRSQPPIDLTGDDSDGDDVVETSNGVHRANGNTTSRSPQTSMFLGARAPESQDGTPSTQFLPKAKQQLPNVRSPFSHSSYMPSNPAPGASRSLYNQTVSGWAPGNAVHGNGMVQPPAPPPINAGVNSSSAIGLTSRNIPSPPPQVYDDKHPICIGSLRSSALMLYPCPAVVVGAVPSPGTRERYDIVEHRGVEFIKVKLKYRASGTLAKKDDPESVLPLETIQVLTPSLTVYIGDLDERVAMPLASLMARGLCRLEGFVPRLHDEAPQYQVHVDVLVFTLPSNINYIAEFLTNHNLFLLDPIPPYDPARHSDHPPYRNAHGSGEQAQRMLAMAQRRALTGDFVFSDKERDKTTQVEVQRKQVDEVFKTLEDGMELEQSDPGPLIKTHLFPHQRKALTFFLLREQDSSCLRQCKKAAKKLLKKRGESEMEAEEEKARKRDEDEGHGSLWEYTRDDKGKIRSWKNRITGEELRGKKGKPTDCKGSLLADDMGLGKTLSVVSLIAATRSSAREYARSKPEPARESPKQAEEDAEMQAGQFRTKIFGMPDISEQLRLDADSKKRKRDEDQTIDAAARRARIACRSKATLLITPMSTISNWEDQIKEHWNGPVEIVGGASGVMPPKKIERKWKPPKANGEESDNEDLDNFDLLRIYIYHGPSRRPDPKFISEFDIVITSFNTLANEYSKQSGSDTESNTPGETANNSGDDIPDNKKVDTAIKPGEVAAAIKGGKKGRGKAKGMETSPLQAIDWFRVVLDEAHYIKTASTVASQAACALEADRRVALSGTPIQNKIEDVWALFKFIRISPVDDKDVFTKYIASPCKYGEQIGVARLQLVMRCCTLRRTKESQHEDGSKILNLPPRSERQMWLTLREDERQVYDERASRAKNKLGELKANNETSKIYVNMLQEVLRLRQICNHVDLAMLGPVEEDYDGTIMDYEVAASGIEKHGLTQQRAVAVVCSQKEGEGANCVSCGFDFGEWFPWIGLGGVEEEKEKPKVKKLTNKPLMTKCLHLFCPTCFKNSVYPEYSKRSKTTVARACSCCNTMIRLPSDVIEVLPPDSADASEQALGEQVAKRGARKKYVRQPGEKLNLSTKMQFLHDELLRFSKRNPHSAHYDPFAMDAENDVEEMDAEGKPFVTKSVVFSQWTTMLDRICDMLDETNIRYARLDGTMTREERSKAIDALKYKKNVEVLLVSTRAGGVGLNLTVASRCYLVDPYWNPSVESQAIDRIHRMGQTRPVVAIKLMIKDSIEEKLDKIQKKKADLATLSLKTMTRKELLAQKASVHMFLIHAKLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K747</accession>
    <name>A0A1E3K747_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035764.1">
        <property type="nucleotide sequence ID" value="XM_019172822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K747"/>
    <dbReference type="GeneID" id="30189861"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="284" mass="31195" checksum="48DC8EE9EEC3AE65" modified="2017-01-18" version="1">MRLNFSVHRSAIFNSFLGLLDIKLGAEIVLLFGLINKVAGLYGLITIVVGGTFPQLLYYAYSTGTLFAFLWGLKVVKSEKSAPALLLSHLYALDHAISTVFHYVFFYKYWYNTPHDGRRTINSQAQQDLINLALSRGEITEPVGGDSNRLDELRAALAEDIWAQEKGFAVWTLVAGWALKIYFILILYSYAAHLASSTYHTLPLTARGRATQIAHPDPSKSSDRTDPHTGGRAAAENDDDEELRKAQHATEEVGSAPAQTQGKGEGKGKGKGKAGGDEDDFSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7J9</accession>
    <name>A0A1E3K7J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035751.1">
        <property type="nucleotide sequence ID" value="XM_019172809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7J9"/>
    <dbReference type="GeneID" id="30189848"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="758" mass="83128" checksum="A981B8C4A0A00E31" modified="2017-01-18" version="1">MAEIPVAAQEGAHNVPVPGAPATDIPTAPGEQPTASHPTASTDPHKPSSQSAPTALPTNPATSPGEQKHAIKEEHPKVVKREVEKTKAEARELKGEPAQGTVVHGVEDDRLWAMLRRFDVQVTHVLHPAHKLPPAEPDLRVSPLPNLPSHTEVLRSNLERVIAAVGPSSVRGAREFQRLMSWSPEERWRTGTYCAAYFTAWVFGYTMLGVTIFLSVLVCFPFTRRYLFPPVPPAPFTPPSATDPTNQKGDESLLGNVDGKTVHRTKHEQAEEQAFEVTSVLRAYTTRLLWDGRKKGKEAGNSEVGQKREDSSDSDSEDEFNPERTKVDGTSDTAQGLDSAAVVVGGENIVPEKPLTDKEKKKLASREAKRKRDETVSKMTKATEDGLGAFADLIERFTNALSPPSAYPENFARFKMAGAFLLPPGLLLTYVPAVYFGRAATFAFGVGMWAQPLLIKGVKKFVELVPDWEERMDMRNSILSRVPTDTQLTLHLLRVTEALGTPLPRPPPPPLAGTPKEAIADTTPATHTAEDDQELLEAQKEGGTTEVAVKAKHKTKTHLTNAFKSAGKHLAGFRGDVSVDGARKQVSMSIEELMERYKIEDRRLMWLGKIGDKVDKVFFRGNVADDLTISSYPCKLDGTSGHIILDSKKEGVAMPTISFVPTSGKEAVFCRPIDDIVEIKKSHVAMARMALGWASGADVEGLGLTIRFKSGEQQLKELTAGPKASKEDGETVHFKRIGRREALFVRLISMGRQRWEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD70</accession>
    <name>A0A1E3HD70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027822.1">
        <property type="nucleotide sequence ID" value="XM_019180193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD70"/>
    <dbReference type="GeneID" id="30197434"/>
    <dbReference type="OrthoDB" id="10423359at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="163" mass="17457" checksum="FEE6056A9880D3CF" modified="2017-01-18" version="1">MAVQKSPVTSTYNLRRAPRAQTPPASAPASASALAPASPAASPPPTPSKSKTTKSSPKPKPKAKTNDPELQSKVIEARRTAYRPRGKGSDLSPFPETTVDGKNPPRIIITPPPDEIVFNSLDLMWHAILYVEGKERLEQTSALGLLADVAGWHRQVMRGSCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF68</accession>
    <name>A0A1E3HF68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_08185</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027882.1">
        <property type="nucleotide sequence ID" value="XM_019180156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF68"/>
    <dbReference type="GeneID" id="30197396"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="20">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN74999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="169" mass="18878" checksum="1B7F47877307C6C4" modified="2017-01-18" version="1">MLQSTAAKRRLIRDFKRLTSDAPIGISGSPNPDNIMVWNAVIFGPPDTPFEDGSFRLTLTFSDSYPNKPPTVRFISKMFHPNIYANGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNPASPANVDAAQLFKENIKEYERRVKKTVELSWLDNTDDLEEATGGDEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLQ4</accession>
    <name>A0A1E3HLQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028000.1">
        <property type="nucleotide sequence ID" value="XM_019180001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLQ4"/>
    <dbReference type="GeneID" id="30197239"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN77293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="166" mass="18136" checksum="3BB03A0A02FEC4B1" modified="2017-01-18" version="1">MSTVSSSNMGSAHNVFTSFDKSMSIKHPSHGSTENIDVQHLVNSEAKSISTENVPTGYILSYVTHGNRLLGSYFSDTHTHLYVASNAASSTPASTDTIDILSRILKGGFCFACHSESPRRVSSKLEVDIARLKEHDDKYKGFVHIKCGGMLPFMRTKRLVKKAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HS71</accession>
    <name>A0A1E3HS71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028144.1">
        <property type="nucleotide sequence ID" value="XM_019179908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HS71"/>
    <dbReference type="GeneID" id="30197140"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="59" mass="6577" checksum="4B9B4C43818681A1" modified="2017-01-18" version="1" fragment="single">PHEPSTYPCAPSDIRESFPSFLSKLNISASSTPSTLASKQDTAFKPVDFVNFWEAPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUQ3</accession>
    <name>A0A1E3HUQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028157.1">
        <property type="nucleotide sequence ID" value="XM_019179853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUQ3"/>
    <dbReference type="GeneID" id="30197083"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="16689" checksum="F24BB061566A7F42" modified="2017-01-18" version="1">MPYLAPGSDAPTTLPIIPRTKHRAKDVPRPAALPSIKKITTAEDILASQLSHIAVRCPLTDSEGEEGEEEDHDPPMLEHESQGHPSPAGTSIRTLSSQGHGGGGGELHPRSFMLNMRFIHTLPPLPHPQVETKCHSEKKEKKKEKATAMKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HXL4</accession>
    <name>A0A1E3HXL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028225.1">
        <property type="nucleotide sequence ID" value="XM_019179803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HXL4"/>
    <dbReference type="GeneID" id="30197032"/>
    <dbReference type="OrthoDB" id="2581860at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="601"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="865" mass="94924" checksum="491369033B395EFF" modified="2017-01-18" version="1">MHTTSCLACRGRKIKCQRESETEVCARCRKKGIPCDTKPRILGRKRGHRNRKTLERLAAEAGTSERAADYRKEAALLGASSKASLSPKSETLSIEESPELHHPNSINPLHILADTSIAHKGQEQLAPVELHDLPQPLRIQDGLQALFSPEQHSRETASRAVENVELSKTDGLASHPEYDVVNVGIVSEEQASLLFDYFMDNLAPLLHMFDPALHTFAFVRLRSTFLFSTILKNAAKYYPGFSHTTLQRLSEHTQGLQMQTYMDNARSIEIVQGLMVDALWLGQAEEGDLQWQERCWQHIATAIMQATTLRLDRLIPFCVSSNMQYQKASAEMQVKLVRNSQRTWLNLYTFDRALALVRGREPLVAEGELSSKRMLATWHTAPGSIDHDVLTTSSASSRQMLIQVQRQVAAQVASDETVRFEDVKMIVDEGFGRWTAQWKSLMTAKHYAIHDIILKASRFLVLMVPFERMLNQGRLNESTLGLCLQESTSACQSIDTWVSRQGGSGIQEARYLCPSITLTMLTYAAVLTVKLMGSKLELTRESHLEDLFRLSTLTQLAIQLQNFGSIPLGKSPAISLGKYLFATLRQIGMVMIRSIRLPLHPSQAQAQSHNRSHSSHPSVSSTITQQSPQYQQPAMVPPIPAPIPRLDSAYNTPNIPSRSHSQSHSHSHHRRLSNSHAPPTNLVNAYPQPSYPAPLPHSTSASTSASAPTAALTKDEYDKYSASSVAFAQLMSSLEHHNPASFHMGYAPPPPPSQSQSQSSQTAGPGPGGDNGIRGVGHGVVNGGLDEQVRGISNGSLGLGGQVNEHGYEAVLGNGDGGAGGGGLLSEQYGYEGMDLSAFGLLLNESTGMNGWMMDYGMPMAGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYD2</accession>
    <name>A0A1E3HYD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028250.1">
        <property type="nucleotide sequence ID" value="XM_019179769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYD2"/>
    <dbReference type="GeneID" id="30196995"/>
    <dbReference type="OrthoDB" id="10443993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="115" mass="13371" checksum="37E952484A24CD37" modified="2017-01-18" version="1">MVRQRSHSIILPSSPLLNDDPSFRSVDDPPSPIFRIPSPIIHPVVIPSIPCDPIPYKRRTESDATIRPSVKQLERENEDWEDVDMTPRAEKETFIFFDIEKEEKEEEGTSDKWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB51</accession>
    <name>A0A1E3IB51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028558.1">
        <property type="nucleotide sequence ID" value="XM_019179417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB51"/>
    <dbReference type="GeneID" id="30196628"/>
    <dbReference type="OrthoDB" id="2577873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="521" mass="54435" checksum="01851010F7789073" modified="2017-01-18" version="1">MSDNSGFVRLNPVSQALADSLCLSSALPGFPSPSPITYTTTTNNTYSDGNAPGLQLYDSSGHSSVSSAPSTITYDPINNDDNALGLQLSAVAPSPTSSGDKPKPKARSSAHVTSTNGIKESGKEKKHAEGCKRKSMSCEYCRQRQRKCDGDNFNACTLCTYNGIECKYVLAKGKRGSQKAFKQLAAMGRAPSADGIIIATPSASSLASSSGTSSMSPITPITPARSTVELSSGPCPTRVSASLTSGFATPHIFMPFVPPTQVMAPTTQLSVAVGAHGMLKDHRVVEMQQALFDNEFDSCCSVLAAVPASESAAPGHLPTPRTTPVKPTYVRPVDVSPVQAPTFSLNDTSVPSALPPVVASQPQLPALTGQGLSESEMLAFDELVMDLDLGDDIVSAPAEVPSSAATIAHLHTPDTTPLKPTVEMSAVSDSADHTSVNFSYAGFLAPDNTPWFITPQTQVGNQALVGNENVGWGMCGTEEMETSDASSWGAIESPFNTTPFGDSFTPVTDEAADSGMRGLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB79</accession>
    <name>A0A1E3IB79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha 1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028569.1">
        <property type="nucleotide sequence ID" value="XM_019179428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB79"/>
    <dbReference type="GeneID" id="30196639"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129661" description="Alpha 1,2-mannosyltransferase" evidence="9">
        <location>
            <begin position="33"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59367" checksum="B566488A75B301E8" modified="2017-01-18" version="1">MFRRIAPPTPQGYAAIIFLALVALWLLSPVDGGVGLLPSSWTSGHRKGTGDWVNPVQPEGEVEDEMDDPPLSLLPKIYASEFPDLKLPPSLLTSPHLYPLAHRLTSFLSRPVLSHKKATAANKAGCPTELADKLVNPDQYNGDSEFWMDEVTEEEIVRRRADVVRYLSEAVDRGKEVRGREGKTGKGRGIVLTGGNQDTTLRTITAIKHLRRLNVDLPIEVFHYSDELQDKNQRKEIEKLGATLREAKGLEKVDGVWKNWQIKGVALVESAFREIIYLDSDNTPLRSPSHLFTAPLYTSSGRAVFWPDLSKDHPDNAIWRIVGDTCSLEHFTFESGQIVVDKAGNGGMNLAALVVAAGMMRDREFWFHMCGGDKDTFRWAFRMLGLEFGVSPRWMGTVGMMNGFQGGKFCGHSVLQHDLVIPDGFTKEPPLFVHSNLLKHLGEAGIQRGTLFTHIRRLSNDYVSSPALNHAHSFVYDGNVRGMCLDLEWHPDTPQEVKEEVGVETVGVEDEEGGVFGGFEEAWWEEGGRVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICK3</accession>
    <name>A0A1E3ICK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028502.1">
        <property type="nucleotide sequence ID" value="XM_019179556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICK3"/>
    <dbReference type="GeneID" id="30196775"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1176" mass="125783" checksum="E68388302444C65E" modified="2017-01-18" version="1">MGDRFYSPLSPLSQLPDDGDQPPPLSLPALHLADFDFDTAFHPDNTSLAPSSAREQPKARPLAHALTIHVPAPLTPSPSPSPSPWDRDEPSIASPPIFRHSPSVARRRTVIQHSSVTYEGNVVDLAETPPRQGTPEHGPVAEDAQVRPASVEHGSIIMPQPQFVGTKTQPASPRRLEKKPATHDLKQSPSSQSVRRSLPRPPKMDTPPIQQPVFAEKAVRQQPASVPVPAPTPTSTWPPLNIERQTVSPVPVEPAQMRPAYYAKKHQSNGSVSSIPVVAGLADAGPYFAATSSAPSRQPTARESPAPVATKAIGLGRPGVPAGAPGPSRVKQEEVCLECMMRDRDLADVDVQGEGVWGRASDVDLTDLIWREEALLKSMGDLNSADLHAKSDDATSEESRAEEDPEARQQGEQERAARHAAIQAKKQEADWRISREIGWRGFKWEEGREGEGLPRNFRGGKGGDLTIEGIKMVMTKFPSASAFRYQKLQDYLRNQWALVLETRAEAQRVGHFAFPDDLSPGSSTSSHEVRAPNMALPSAVAYASARGASGSSPRHATGGMRPSPSSPAGFSLSSTAAQAPLRQAPLQRPLTHYLPERELMTMRQPVTPTNRVDAFSHSNSMLTPQSRHFRNSPSQEPDTEELWSPDDEPTQNLRPFSFAVRAGAVARDGSEGGHGAGARKSLFGRWGGSVTSFFGGSQNGSGSMMDMHVGLESDKRNKATSGAYPRAVSLASPTRPSFFSNSSSVQSHDPPPQRISRAISHSLLSRVQIGEQEEGGATKKKGIKGFLKKMTGGKKKDGRSRANSIAQPSVPSMPVAQPETPLAPPPPISVLVGGRDPSHARQGSGSSSSMFTDGQESGSNRLSGSILYNRSVSAPLNNASSSDVSVGQSGSPASSRFMTTGQTKPESYSSTGGKRRSTVGEMGEERRSVMEMFTHAKEDGGAYDEIPASLRPGRPNNKTNTSLSASSGTMLETPPALNYGSGSFFSQQQTPGKLTINTDMPKHTPSNSIGSLSPNRYKNLPPIPPGDLGSNYPNQSTGSRGVVGSPDSIIAAFPDQEFAEYGGRVPTRQPTGPGSPFYNSGYPQPRHHQQMSQQRLQPTSAYAPGYGYGGRASLDQRASSPRVERGGQRAVQTMYGMPAGDEYGAPSGGFGPVEGDKKKKGLKGFFGGGKAGRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE09</accession>
    <name>A0A1E3IE09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028846.1">
        <property type="nucleotide sequence ID" value="XM_019179229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE09"/>
    <dbReference type="GeneID" id="30196431"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN86854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="63" mass="6354" checksum="CA258FD2D05735B3" modified="2017-01-18" version="1">MSYQIAGRAIKNEYLALGTIISTIGIAMAATGGDKAAAPASSAPVAVSDDKTITGETPEEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFM4</accession>
    <name>A0A1E3IFM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028960.1">
        <property type="nucleotide sequence ID" value="XM_019179042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFM4"/>
    <dbReference type="GeneID" id="30196235"/>
    <dbReference type="OrthoDB" id="2577115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21348" checksum="F2EF286587249087" modified="2017-01-18" version="1">MSLDLSTFSPNSRHGNFSNAYTGHMCYCPMHLDLSAPKNSVGEWVGSGRPLTPGDPVQLVTFEDGKSTFLCGGCGVSAVRCSKGDPDDNEMVVGTVTRKTMETARIYEDYRNTFEKAVSVVPGYISPEGEIISYWVEATPFKIDRDTMTDPDTVSRTFSEFAQLQTVDKSNQSLAEEWWYQDWENDSQHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN5</accession>
    <name>A0A1E3IHN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029006.1">
        <property type="nucleotide sequence ID" value="XM_019179087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHN5"/>
    <dbReference type="GeneID" id="30196284"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="85"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="51847" checksum="53F6BEFDAA4301B0" modified="2017-01-18" version="1">MVSTRPSPAPPKGRVAYPNAASYTPGDASNSPAYLKPFSPIKPVTSRDSEKERAQGLKTWWKGFREKEAAEADKLAHDGRVVFGVPLEVSMQYASSQVSADGADGALYVFGVIPIVMAKCGLYLKENATLVEGTFRVSGSAKRIRDLQTLFDTGPSYGRNIDWKKLPYTSHDVGTIFRRYVVLPEPAIPYRFYGAFRLVMERHLSQQTAFEEALEEYKNLIKALPEVHRNLLLYVLDLLSVFDRRSDTNLMNAANLALIFQPGLLSHEDHALQPRENVLSQQVLEFIITHYKSISETIEIGKPRQKSAKKKPRRKSKPAKPQRPPLVKADTDLMLPSDSDDEAPSGGYYVVEASVKKPPLPSPAPRPLPPSLAQRINSERVNSPPPAAPRTVSLMDLIDPSDSDDDVPPGGYEVRTGNFAATRAALLAKSQQAELDKAASKGSTGLSRRKTVPAKVGAGLSKRRALAVREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIY2</accession>
    <name>A0A1E3IIY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029297.1">
        <property type="nucleotide sequence ID" value="XM_019178814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIY2"/>
    <dbReference type="GeneID" id="30195972"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66203" checksum="D3334A042CF96180" modified="2017-01-18" version="1">MATRLPAKPPPPAIFPKLLPLLISRLTTQPVDIALIPSIETAFYILRVLTLYPDVVQGVPSASAKSLVPLQKLLEISTSHPSSIKPPLVLDAIIAYPIHSPVVRQVVSNVIANSPDVIEVYRIDVLPDLVDRCRKGSQKQVLLAVNLLLGIMRVHDELLALILEASEDILKGLSVAYAKLAEDSQGVVPDEAIFSGRDDILVICRELLVRVGLEGSASEAMFRFMDGGQGGMEAVLEGRSLRKDCEKFVSKDQGAFNPSSWVVASLNRRRDELAKKDARVASILALFPTIPAHLLLAALSHPQFSSIPSGSRTSPGELAEPLLECLLNGGQGLPAELSHLKELASKLGYLQASADAPEEVPQPKKKFERRNIFSAEDLDMSRLRIKNDETALPELQSTIPSHLRDSIQRLIALQIDEEEERRQALAGANLLPSDDESDLDESGEIPLRVKVSGGDSEDTAPIDSDGDAVKVKQQKQSGNRLPDREVHMVLRGLYLDDPGLFDRDGATRRSDQRNKLKERTGWDDGQIEGWKVMLERDPNKDTILEAHRDSVGRNFRAPSPTLSTTSNQTQGSNRGRRPNKGNRGHSNAARTRGHDRKMRQMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK35</accession>
    <name>A0A1E3IK35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029353.1">
        <property type="nucleotide sequence ID" value="XM_019178652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK35"/>
    <dbReference type="GeneID" id="30195809"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="83" mass="8959" checksum="D57BA1854020D27B" modified="2017-01-18" version="1">MTRGNQRESDRAKALKKLGDSGKKQTGNPQARREADAKAVAEKQALKAKARAEAEAKGELSAFDAKQEKRKQNTGPPGGLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM10</accession>
    <name>A0A1E3IM10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029543.1">
        <property type="nucleotide sequence ID" value="XM_019178387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM10"/>
    <dbReference type="GeneID" id="30195533"/>
    <dbReference type="OrthoDB" id="2562154at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="15682" checksum="CF45188B072DC116" modified="2017-01-18" version="1">MPIEVTPSPQTMMSRAFLPPGWSSLPPTGPVRAVNCVPRSQAPNSVMSNGLRNPWAPYGGETYSPSAQAGAIRSEQRFAGADSAAGGSMVGSVMGGRPRAMSSVMSGGGGSIIAPSSIGMGGYREDDGWNGSMGREEGMTGDISRQGGVIMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM87</accession>
    <name>A0A1E3IM87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029611.1">
        <property type="nucleotide sequence ID" value="XM_019178455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM87"/>
    <dbReference type="GeneID" id="30195605"/>
    <dbReference type="OrthoDB" id="2960209at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="31159" checksum="87748122A0334B5A" modified="2017-01-18" version="1">MNPTQTNTFHHRWSHHPDVDYHFSHRFRWPAAPVEGASGAAANAAAEGAAGLASGGGAQPPPRGPYGGYHHYYERGPYRRWGRRPSRFIWFSIGAITATVWYKHHHERKNDLQKFVTDPQCWSPHHRTLPPPPTETPTASVTPAVPSPAPSATDSLPKRDSSWWWDDEKRHAGWRAWKEQKMEEHRARHEAKALQAQAPVDTTSSATSGETAEFKSLREAVEKLWAEKTAADGTAQKVNDQAREYASEKLEKLSVALENLRESLKVDDKPQGDKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM89</accession>
    <name>A0A1E3IM89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029379.1">
        <property type="nucleotide sequence ID" value="XM_019178678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM89"/>
    <dbReference type="GeneID" id="30195835"/>
    <dbReference type="OrthoDB" id="2578259at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="188" mass="20349" checksum="A8FD5A626B6834EA" modified="2017-01-18" version="1">MDEYLPGSQARRVAKGMFWAWHQEAWAKTATDRQIRSAWAKAGLWPLSAGIILGKVNDPLTHPPQASQPAPPSPRTPLGPRRINTALRNGELDPVVAVAHAKTAAEVAKSESVLLRKELEEARAAMGLDKATRGGGKAVQNPGGGGGDDNREALEKREEKEEENRGFWAKRAPHRPAGAQSNEQQACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM93</accession>
    <name>A0A1E3IM93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029632.1">
        <property type="nucleotide sequence ID" value="XM_019178476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM93"/>
    <dbReference type="GeneID" id="30195629"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="86"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="760" mass="81896" checksum="D6ABF29FB0ED5A1E" modified="2017-01-18" version="1">MDPLSPSDDINAGWSSPTDHTDPVPPSPAPPTTASSSGFSSAASWSAAGLREPKIFGAPGMGLVSPLPDAQSDHATTNGAKEPPRPYLRVRIGTLERNRKDLLVRFDASTNLQHYRLPLYKNMQRSYVEFQKFAEQVQLLCPQTIIPALPLPSTSAMTDEEDDRLVRIALQRWLSRVCEDPVLMKEHELRSFIEAEFSYNPITPQSARRAGSSTVLSALTKVVRRGPLDEDDELASAKIALEKLEERYAQAATCVNQLGKARRQLAQSNADVGARMISLSTVESEPSLSGAERKMGRTWEHGSGLMGSQAAHENVILSDSIGYQALNARAAKDTLTQRTLVLEDAQAATKSAINKRRALERLKGSSNINQNKVDDAISEMQEADALEDTLSKRVSAISENLHTSLRAHSRHAHEDIAISLLEAARMSVMYHKQTLKELESLKVDVGKVAPGAAPLPLEKRTAAQTQVPARVPPMVRPPPPPQQQASFQTVRSPPAQVQAVQPAQTRVQGQYPRGVPTSQQAGPSQPPLEAGYPRHANPYQNQPVSPFHSQPSPSPYHSQPSPSPYHTQAAPSPYHTQPAQNHPHPHPHPSSPQYQTLGAQSPYANQPQFQIPPQNTVPQQGYYPQTGPAPPRRVPTSPPRANLVPDGSQSMLLPANGAGGIQRPHSAAPYSDGGADPLGGFRPPAPGQLQGFPQGQMGMAQSMFVPGHPGQPGYPGYPGTPGAPGTPGMYGPGQGPQRAGSMGRKRLDERKAAKLLAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INL0</accession>
    <name>A0A1E3INL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029706.1">
        <property type="nucleotide sequence ID" value="XM_019178268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INL0"/>
    <dbReference type="GeneID" id="30195414"/>
    <dbReference type="OrthoDB" id="10277730at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="219" mass="24017" checksum="64168FF542F67770" modified="2017-01-18" version="1">MVSTSMQRHKTGRRPARSTPLPTDTSLSIPLAPIVVNSYDFASTPGPLPANAPLPTVPRHIHAATLQQLANTSSPAHPPLYVSIKVKVPLAPLKRISTMSMNGGEKCKSRFRFEMWSWDDEEGVERPRGRWGPGAGYGMEIVGGDEPKASNELDQEAARAMYGREEAYRTPLPAISYDLFSQLAIDYASDGSKRRTEEMIERPESAKRTRAVGNVGNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INL8</accession>
    <name>A0A1E3INL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029719.1">
        <property type="nucleotide sequence ID" value="XM_019178281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INL8"/>
    <dbReference type="GeneID" id="30195427"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129856" evidence="3">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="26124" checksum="FEA641E3D16B6EB6" modified="2017-01-18" version="1">MRSIATLFPFSLSVLASPRTPLTYLVPFSTIFTLSVSPHTPLLSLLDEPRLPPPNAAQRNRRTLAGSLPPRSQAAGHRRPNPSPPHSTSFNVACSQRSSSQCANRYGLFPEACVPQTHIRFVQLLLGFHFAHPLPSTSSTMQHSTNSRNWTPALHEWADTLIAFLTHDIPPYINAQVATEVAKQLREERRHVETERDYARHRWMSGVAGVRVGRRSRRAHSHTVFDSPLSPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP41</accession>
    <name>A0A1E3IP41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029605.1">
        <property type="nucleotide sequence ID" value="XM_019178449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP41"/>
    <dbReference type="GeneID" id="30195599"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF39">
        <property type="entry name" value="THIOESTERASE_THIOL ESTER DEHYDRASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28658" checksum="4925B0A30BCFC19F" modified="2017-01-18" version="1">MPPKLAVTDQDIVNLQELYAKFQDPTSHYHIPPGTNGPEHEEDHASSRTPDLPTLLAKAASIVQSTSSTAEIQAVHGDREIANDRPWQNAEGGAQQKALDYFRQEGHDTVGVLTWPVAWGDQDSFQHVNNVQFLRWIESARIRYGESWGPVLGEKAVYDLLHAKGTGFILKDVSIKYRAPITYPDTVMISNRIHSVNPERASYGHQHIIWSMKDGQVKALADSTVVMYDYDNLKKGVMSDQFRELLQSVEYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ48</accession>
    <name>A0A1E3IQ48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029829.1">
        <property type="nucleotide sequence ID" value="XM_019178110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ48"/>
    <dbReference type="GeneID" id="30195255"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129949" evidence="2">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="532" mass="52107" checksum="3422B14164A13626" modified="2017-01-18" version="1">MRTSTTLLALSAAAGAAQAVDISSVESSALALLSSSCRSAYQNLTDAQSDIGKCLKTQAIGSLLQSKGSIIPGVNSYLNNICADDPCSSDALANATQTIQTECASDLTNYGWPNETVQYLVSSYPLAREVFCLKTTDPNQFNASLASNATTSSNSTASGVSSSSSSAAGNATAPVSSASTAVSSASSSAESLSSSVTGSVNSAAASVARRQEASDSATTASASLTGDDASGPTPTASSSASSVSESSSASDTASVTSSAAAGVSSANSTTAGNSTSAGNSTSNSTSEDTGSFCVISVLEEAFSYLGYNLSVSDIATIVIGGNASAVQTLLAIPPSALCSDCVFGALDLVETELPDFGTWVTVDNVTLNSYLDTTCTATGLNVSSNGTLPTNVTSGTSNSSFGHSFVNGTATYVPTSTAPAIPAASILGASGNVTVGNTTFGFGNNITANETFSTSIGTNGTSSTVGAVGSAAESATSAAGSATSAVESRLSSVTAGSSSAADSASASETASATAAVRRGDPALIKARWVGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ85</accession>
    <name>A0A1E3IQ85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029861.1">
        <property type="nucleotide sequence ID" value="XM_019178142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ85"/>
    <dbReference type="GeneID" id="30195287"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="78043" checksum="DDA227F72BFBF33B" modified="2017-01-18" version="1">MANFFETEFGLFDPSSRFESDYLSFASLSSALSPPPLDPHGYDPSDGAAGFLSDSSSPAPSDSFDSYPGLFDPATPPSGDVVGIFHTPPKSAGYESSSFLQAQGSPESSYNTFSKIDMPSSSSSSFPLSIPTDEIFLSSPPTGSYSWDEAAPVAASSSFQAPLPSSKPLRVASNPTLGPSRNTRHVKHVTSMPELQEQGQGSHEWLNPSQYSADPQGFQQFPTGPSSKESLVENFDSVFGDYGLNKNNSGTTGFEFQSPTDQSYSCDIPTYYTALPHNGETQWGFGPSTNMPAHVGLFPAFELPQQVIHAAAPAEQNTLTINPTAVMKGDAEDDASRPWTAPGKSGEKVATLSAPMSEPMAKRSLSSSGYKTSKYTAPVRDLFSYAPHQHSSGDRPLYTCDPSPTYYRSASSQHRRAMPSTPTPQPRAARVISDMFSAPQEGQFSRYPTAYPPTPNSPAFSMMSAVPPLFPAPVTMQRAETTPIPAAHQTSRSVTLNPSLLSGKSTRAHDDDDDDVERMRPRKRSRRVSMTEPRVMQHTLRRTTRQNHPRPLFASHPQIHPPPMGSSALPTAPLVTVHPPPQVHPPPIEYGSGGAPSTPRRVHPPPHPGSAGRPIARLPSPRRQSPIVEPPTPLMTAPTPRGKRRATPPKKRTPSSSSSASGVGDQQFRFGNAMFVNFTSEDADLLLAGVAPSGAMAKKKRDREAALLEQEQERYRVKRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQA8</accession>
    <name>A0A1E3IQA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029892.1">
        <property type="nucleotide sequence ID" value="XM_019178173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQA8"/>
    <dbReference type="GeneID" id="30195319"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="21446" checksum="CCDCBABB9656907F" modified="2017-01-18" version="1">MSIAAYRRYSTATKNKRVITGINVRLDNELRGIKAGIHAFRSTVAREKASQEASRKASIVEASRQRRAPKWVPVVGERVRISSMGYEGTLRFYGATEFKEGVWAGVELEGGFKGKGKNDGNVGGVQYFSCPPNCGIFVTAVKLSQPTTGASHPPLPHAIVHKPPTLYPAAPLPPCLAELPLPDLHLSPQAVPRVPSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQC8</accession>
    <name>A0A1E3IQC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029906.1">
        <property type="nucleotide sequence ID" value="XM_019178187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQC8"/>
    <dbReference type="GeneID" id="30195333"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="307" mass="32598" checksum="D2F5F1271E456CEF" modified="2017-01-18" version="1">MVNVFITGASGFVGSHLTPILLAAGHKITAIARSESAAQKLVDQGITTIRATLEDIDVLAKAAGEADAVIHLGFIHDSRTYAESVEADLAVITAFGTALKDSNKTLITTSAIPVAGVPAPTELSPGKIPPRAASEKLTLSFSSPEHSIRSHVVRLPPTVHGDTDRGFLAHYIGQSRKAGFAGYIGEGENHWPATHVKDAVQVYKLVLENASSSLKGGEVLHASQEAGITLKTIASAVAKRLGIPTKSITKEEAGQTYTFLALFLGIDCVASSELTGRWLRWEPVEKGVIEDLEGSGWYFEETSVTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQF0</accession>
    <name>A0A1E3IQF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NifU-like protein c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029914.1">
        <property type="nucleotide sequence ID" value="XM_019178195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQF0"/>
    <dbReference type="GeneID" id="30195341"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="31729" checksum="6B6227D46B4B13D4" modified="2017-01-18" version="1">MSRTQTTILRPLATSSRATRNTVARSFASSSRQQLATSSSAFAGIRASHGHELRRKPLALFSHQQRRTMFIQTETTPNEASLKFIPGVEVTHGSAHEFLDLRSALASPLATRLLTIEGITGVFFGPDFVTCSKDESLAWSVLKPEVFAVLMEHFSSGAPLFKEGSGETTAEDTRVLDTDSEVVAMIKELLETRVRPAIMEDGGDIEYRGFNEVSGLVQLKLKGSCRGCSSSSVTLKNGIERMLMHYVPEVQCVEQVLDEEEQIALDEFAKLEARLEKEHGKKPDGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQG7</accession>
    <name>A0A1E3IQG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029880.1">
        <property type="nucleotide sequence ID" value="XM_019178161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQG7"/>
    <dbReference type="GeneID" id="30195307"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="63" mass="7191" checksum="ED47BA9C76B5F940" modified="2017-01-18" version="1">MRQYELTLLNRQVLLEAYVSRRIGGVVIIFNLSFVVKVTGRDELSVSHIFQRDAPENAKPMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS56</accession>
    <name>A0A1E3IS56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030073.1">
        <property type="nucleotide sequence ID" value="XM_019178034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS56"/>
    <dbReference type="GeneID" id="30195175"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129913" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="97"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="352" mass="38018" checksum="EC8451AE2CC2975A" modified="2017-01-18" version="1">MLSTTTLFILLAVSARAVPQGWHPSHSHSHTPTPSTSISSTTTTASTASSYTPPAPSQTYPVLNLAEPPENCTCGYAVQSLGGAYYPFRYTFTPSSLDDGTMTSPDDLLQYGLKINDGKHAGGEGEDGAQCWGRYQNVRIEGDDLVLTVPGGQTLGPDMDCAEVTHNVYQPLGLSDVAGTCEAFWLNHTIADTFADEVDIEILTGKLESDGIYHTNWPPFGNPNDPSSLISNYTQIVPFPGLDTRSPTSTYNNYTIVWQADRLGQNGTLRYYNGEAQQNPRTIVSPLIFVPAHAMEYNINAWSNGAPGWSAGPPTADSELRVKSILLYYKTETVKSIGDISAECSSSDVCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISQ5</accession>
    <name>A0A1E3ISQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="14">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="14"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030111.1">
        <property type="nucleotide sequence ID" value="XM_019178072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISQ5"/>
    <dbReference type="GeneID" id="30195217"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN91485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="339" mass="36203" checksum="0660B65A0CB8DCF7" modified="2017-01-18" version="1">MAVKVGINGFGRIGRIVLRNAIEHGDLEVVAVNDPFIDLEYMVYMFKYDSTHGRFKGTVETKEGKLYINGKAVTVFGERDPANIKWADAGAEYIVEATGVFTTSEAAGVHLKGGAKKVVISAPSADAPMFVCGVNLEAYKPEYKIISNASCTTNCLAPLAKVINDNFTIVEGLMTTVHATTATQKTVDGPSHKDWRGGRGAAANIIPSSTGAAKAVGKVIPALNGKLTGMAFRVPTADVSVVDLVCRIEKGASYADIKAVIKKASESPELKGILGYTEDQVVSTDFVGSLESSIFDAQAGIALNDNFVKLVSWYDNEYGYSRRVCDLIAYIAKVDAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU06</accession>
    <name>A0A1E3IU06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030012.1">
        <property type="nucleotide sequence ID" value="XM_019177973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU06"/>
    <dbReference type="GeneID" id="30195112"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN91386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="477" mass="54028" checksum="88E0FE0ABC0A7DAB" modified="2017-01-18" version="1">MTPPQLFQLPHRRVSPQDKQSFAYTTLVKRWPVVLTNVISTVSNANHEAHVGSAPDKDQRVEEGKKIISQISEMKYEMGHDAILTPIKEDGDINVQCYNEELANFPENERTWGTVNWLWAECYVYRRLRSFFAATTLWKEYDPFFDQKAETYKSSSAAIVQLAKAMNTAHGEKDDLARDSEKTGSALEVAFLEMLQADLWGNATDLSLLIDLKYEDLQKLQAVGSEAQAEQAKFILRNDMSKAWELLKTLRDGRVDIVLDNGKQYRLLYTDFILADFLVSCTPFVNEVVFHPKAIPWFVSDVLPYDFTWAIDSLLDRSFFQDAATPLSSSDLDSLTTIAQRWKSHVESGRFKLSVPLNTKLGQAPEVGGFWTTQYAYQDLPATAPEVLKELQKSDLVIFKGDLNYRKLVGDAWWPTTTPFEEALGPLAGQINLLSLRTNKADTIAGLDEGIAEKLDKEAPDWRVSGKYAVVSFSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVQ6</accession>
    <name>A0A1E3IVQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030304.1">
        <property type="nucleotide sequence ID" value="XM_019177553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194683"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1869" mass="210829" checksum="2F0267E48CF5515F" modified="2017-01-18" version="1">MPTLPSLNPFSRSPNAPQDPHRTLSELLHGANTQNGSRWSNTVKASLIRQLWQTVWHDPEWVQYFVPDDQAGSLPKQAEIKDWLVDTPEALYQSWSLSATQKALQEKKSREGKGPIWPPRAGQVCGKVFQRHERTYTCKTCAIASAVSLCVDCFKAGDHEGHEVLFSQSFSFSACCDCGDPTALCDDQHLGCSHHPRLPLGQTNPPTPSKFDVPDGLVIALQKTIAICVEYIIHVIEHSHLPADYGQLPKTEEEMRSTNGPTGEPRERWGKGPWAVVMWHDDKHVMKELARQVRDGVGVKWEVAEQWAREADTVGRKVILASPNPVVAFHAANMLHQVDAAVSLRPAADVFKEEIVAVLIEWLYDLRASIIGGDDRLSKRLLANALFEKRVLPPAAPGTPLTPDLNDLVNGKILGKPQEIKRIDWLLQLDPRLWKKAKWQMRQIYCSIFLNDQECSYFIACRFALNYPRIAEHFLFQDREFDTNILFSSGYVVLTNGPAAAYATAHDNLLSNIVQVAQAWYTGQVVTTDGVDRLVIPPVSLDMVDQAQKGRLDLEIPAFSVAGKKGLAIIGHIRSAIKHDETRRVIVKQNQLFNRLLGFVNIFVGIQPQRREKGGHIEYEIEWLRSFIVLGDLSRLCRDMGEIFSVAAPDALLQSMSLVANRVFCDMFLLSNTLDKERYLPITQHTVNNVLVPGSSAVLIKQDISTIDAFSFHHYLNLLFAEMMKNMRTAITWVDGKVNGMGFVEVVEKFVFGGGDKASCERMKLMMLEWPLQKHVVFAQIRANMWKKNGSALRLQHHHYCDVSVRESTIDQELFLLQVGLCVVDPFKFIIACIDRFGLGDYFQGSVTDPRLWYDEDLEPKQKINLLEDFLLLIIQLATYPVFINGWDRRKLTRKLIIHLLAVQPMTYSEIYRKLPERSQETSCSPILSEVANFRSPTESAPGQYSLKDEMYNEVDPYWRYYSRNDQRAVTDKLVARAKRLSGLKDEPLVQPLPLELPDSGQPFSTIADFLGTHVVADIVHWAFAHSMHIATPEHPVIPTWDLVLDYALHLSMLALSVNAQEFAQQSVYLKGSEGSNSTFQNLWVMQSDAAFQPFRARVDYILDTIVANLPPHYTADYRAHKESENLIALSSPAKPDPKASAAARQKAIMAKFAKQQQQFAAMMDGADDDDDDIEVEHGVKEEEKSFGNCIVCQEEVTAKNPGGMLTLLQPSRQLRETVNSRDWLEESILVPTSLDRSGRYQRYTHDTQHPEPASTEGYPCTNMKFGIHMSACGHYMHENCMTSHFEGTKVRHTQQVQRHHPENAVRLEYMCPLCKSLGNVLIPVEPTRTTTKAAVAANKDDDVVPTLSMVIRRVSSEGLLRVADSQRIWEHHVETGEVVPWFSDCVFSLHSLDHSHRRGSMRVISRMADRMGGLVRPLSEQSQRIRGKKTHMYLPDDMVAYTASMIEITQRGHKNNSADALTVAEQINETSLKLIGKLVGLLQLELDLYFGPSFDRTSLRVGIFARFLPDWYRSSTLPSPLLIRHPLGMVIECAAIAPDLLQAVMIMAYYAELTRCMLALSLYVKRCLGPRQSPALRTQPSSDESSADALTVFANFRPVMQSILRHAGPFADTDGVLALLSDEMLSKLLYSYTLPFLRRCAIIYYAVTGTYPLTNPSLISDFTSSTSEYNRLLTVLGIPRPTETLGNPSSTETPIVARWITQWALHGRVMPVLEYPGTYELVRLPEKWEDLVLAMVNRKCQKCKTKPIWPAICLFCGTLVCLAGDCCLQGEQGECNLHMRECGAVVGMFADIRRWSLLYLYAGSGSFGSMPYLDAHGELDVSMRRGHRQYMHLERMDALRKTWLTHAIPHVTARRLEMTLDHGGWGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW11</accession>
    <name>A0A1E3IW11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030230.1">
        <property type="nucleotide sequence ID" value="XM_019177846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW11"/>
    <dbReference type="GeneID" id="30194980"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="534" mass="58531" checksum="252190580A9DFEE3" modified="2017-01-18" version="1">MSGFPEHVNTSLAQIDALYETLNKRFASGATQTLAYRLYNLKQLGHLVNDNLERIQAAVEKDIGKGGFDVLNGDLWIIFNEIELAVRKVETWMKDEGRMGDALLSMQSMRPRVRKQPKGVALIISTWNFPWQLSLNPLVGAIAAGCPAIVKPSEHAPTSSALLAELLPRYLDPEAYGVVLGAADESKALLQKGWGHILYTGGGEVGKIVAKAAAETLTPSTLELGGKSPVIISPCADLKIAARRMFSIKVMTAGQMCVAPDYVLCPKDRVDEFIAACRQTLDEFYPPYPSPSSLLNSPHTSSLRNASDYARIADYVDKAEQEGKLVYKGERDETKRRFGVSLIRLNDGGVGESGGVADEEIFGPIVAIVPVDDVDAAIKYVNARPHPLALYVCSSKRSVFTKVISETTSGSATWNDFGFATFARNIPFGGVGASGWGNYHGVDGFNTFTHQKAILEIPYLFEPLMAVRYPPLSSFKKTLITWMMFSGMPYGRPKSVEDEARRLWKKKWGWRAVWGVGLILGAGAFAQKGRFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW33</accession>
    <name>A0A1E3IW33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S small subunit ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030434.1">
        <property type="nucleotide sequence ID" value="XM_019177683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW33"/>
    <dbReference type="GeneID" id="30194816"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="257" mass="28677" checksum="738594FCA5A15D46" modified="2017-01-18" version="1">MARPLRSVLTIAGSSLAGPSRVSSRARAPVQVRTAWNMADLSRNLRLPWSKENATTSTTDEPLPAQITDEPTSSSDAQGNLFDSVTAPVKDSPKNKKKLAKRGTNFEWTEHSYSSAPHKISPRKLNLLSRQIAGLPVDEAIVQMQFSEKRASKWVKSTLALARDHAMDKNLKRDKLVVSEAWVSKGQKIGRIDIKGRGKYGILHHQSARIHVVLREGSTVAEKQQIQYDKAIRKVRSAGQVREDTPLRRKVVSGWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXQ2</accession>
    <name>A0A1E3IXQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 25 (Mitochondrial citrate transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030518.1">
        <property type="nucleotide sequence ID" value="XM_019177365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXQ2"/>
    <dbReference type="GeneID" id="30194490"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN93413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="31571" checksum="3E31243304184A4E" modified="2017-01-18" version="1">MSTAAKGSKEKPIASLLAGATAGGVEAFITFPLESVKTQLQFGALNGDKPMSPYTALKTTIQQRGVKGLYAGVSAVVIGNAAKAGVRFTTYDQFKSLLKDDEGKLTAPRSMLAGLGAGMSEAVIAVTPSETIKTKMIEDSKLAQPRYRGLVHGVQTIIKEEGYLGIYRGVGPVMLRQGANSAVRFSSYSTLKQLAQGSVVPGEDMPGWMTFGIGAAAGIVTVYSTMPFDVVKTRMQSIHAKQEYRNALHCAARIFKEEGIFKFWGGTVPRLGRLVMSGGIIFTVYEKAYPVVASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXU4</accession>
    <name>A0A1E3IXU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030353.1">
        <property type="nucleotide sequence ID" value="XM_019177602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXU4"/>
    <dbReference type="GeneID" id="30194733"/>
    <dbReference type="OrthoDB" id="10470295at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="51385" checksum="3A273E9E91FECD8E" modified="2017-01-18" version="1">MNDGQRSLRLSIDFSQYTHKTTHLLAIISTHSQCQRDLFPSPFRPTPPTPSHALRRKVWMLLFRKDRGMMERAEREGLVEWVEGDGIEGAGKWEVGDEWDEGVYNPIGDWVEELMETFRHELYDKPGMFDRRWTSWEDVADEDEEDRLRELCPHYFQLRTLMDAAGLLPKLIKKPKPAPPIITISSDESDGSEDGAAPPSWRVRRKRRSKTSDTAASSASAFTSSPSSSSDSDSEDDPIPLSPSEYVVPRRHTPSLPYRPRPPKRLSPRPLPPRPVRNLPSSSSASETDTEPLHISGHFEKRARRPDTPPLGHLPGIYSYHDELDRARVMGLFDFAPPDQGDGVGVEVKVIPESMELDSEGEPEWGGDAVVKVVLQETDGRPWPSDIVAEVHLPEPEGRRKRKRARPGEDTGRGESERRVKRKMRIPNLQIAKDDLNRKAQKRMGVVLAGVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY99</accession>
    <name>A0A1E3IY99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030308.1">
        <property type="nucleotide sequence ID" value="XM_019177557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY99"/>
    <dbReference type="GeneID" id="30194687"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01702">
        <property type="entry name" value="PolY_Pol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="37"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="605"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="702" mass="77675" checksum="B381FED46757975C" modified="2017-01-18" version="1">MSFIAGPARKSQGNVVPTYRHLLSPQALTPANPLRSIAHCDIDAAYAQFEQVRLGIPDEVPLICAQWQSIIAVNYPARKFGIKRFTSIDDAKKMCPHLVVQHVATYRNGEAEAGYWENVDSRTHKVSLDPYRRESSKILAIFKEMIPKGEVEKASIDEAFLDLTPMVLERLLIEHPYLAIVPEDAPNGMDSPLPPPPPIDWNKAGTVFPKDGKEHDDGEEGEVTSEDGERVRGVRDTWEDWALCLGGQLMSEVRGEVYNRLHYTCTAGIAHNKSLAKLCSAWKKPNNQTILRSAAVAAFLRDREFTDIRSLGGKLGAAIAQEFDVTTVGDLLTVPLDTLQKKFGEESLWIYNVVRGIDLSEVKERVATKSMLASKNIRPSVTAPSQGYHWLSVLAGELNVRLRESREVAPGLWPKTLVLGTRQGFEAPRSRQAPFPFTRNLSTEYILKYAHKLWEEATQPMNKGNMKLNNIALSFTGLEKLEEGQQGIEGFFSTAKAVPKSAKADPDSLSTSSGPPDASLSAKRAHSPAPSADPVHKKPRLPKLHAVEPKTSLQAFLAKAGPSSAKPLPSLSRTSSYSDREERPSTEAPEVFVVDDSDDEVESQDDGMSWTCAKCKKLISRPGDFAMLEDERPELLRAMKQEHEDWHFAMSLQDGGEGSSHPSESKRRAQGKATGSRSKEKPKTTVKKKKEGIQAFFGPKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYU4</accession>
    <name>A0A1E3IYU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030690.1">
        <property type="nucleotide sequence ID" value="XM_019177537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYU4"/>
    <dbReference type="GeneID" id="30194667"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="959"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134575" checksum="6A8EA06FC9217FE9" modified="2017-01-18" version="1">MSNLKRRISYVLPNPSPDAPPPLLSLPPFDHDKKGHPTPFILPKAAPTFGSRNPFLQTKRDSQQRKSPGHPQHCLGVEALALDTTTVLEGDSSPGGILYTAGRDGLVASWDLDIPHTRRFSPRYSSLDGKKKPKRIRWESIGDDAEFFEDDDEVDPAEGSGSDEEWVDMKKKFDEVPYEDRWEVDKVELAKRSPQTTFRQSAQTHTDWVNAMLLCNYNRTAITASSDRTIRAWTPHTSGDDESPSTPALIGTHDDYVKSLAWAKGHGYLWSGGLDQKIHLWDVKETRGSDPILTVPITDADDQRGSVYTLGTDQAGTTLAAGTAERTVRLWDARSGPKSTGYLIGHEDRVRSILISDSGKYMLTGSADSTIKLWSLSAHRCLHTFTHSSSSIWSLFSSHPNLERFYSGSRDGHLCAIDFEGCGDISQGECVVLAREGEVEENGRRVGGTYEGEEGIRSIVAMDDEYVWTSTGSADVHRWRDVGRRISRLDKDFGGTSFKRRSWLDSNPLSAVDPINKRLLDSGEDGLTRTDTRDSRSISFAPVPAVRNNSDEPASPISPVSAVPPALRDRLNHRSSLSTSSFVSDTTTPEEEDVGTRNGLPYSALVNLAPDEGVYGFGAASGSVASFARRPDEPRQPTDPIDPNKRSAFLNRDVDSAAIPLRPTPDEDGRIQGREGLIRSGTCLDKQHVVTVDTLGGVAIWNIMSGLCIGIFDWQEIAEAFHITVKPNGEAAVRKQIRRHASDVIDLVRKRVDGEVEIFPWLAGIDTKIGSLVVHLDEGRVFDADAFADELGLSGGDIDEDIRINLGKWALSNLFRGLILAEEHEVTSQVPPLSSPSNPAFLEAPHAPSRMRAPSLSTPIDRPQTSAHRKRAMTGSFSKTRPTLNIPVTSPTMGRQAVFLDMPDEEAREGGREEGWRGFDTSKAGTPGRMGLSGPPTVESHTFGMGSGVLSNSYTSASGKDYFSPRKTDPSPPGNANGGGKESNGSIGKSPATPGGGGLMGKLKNLGKKKTAESAMPAVQEREIFKEDTGPKVSERDAAQLEMLDLVRSHHFHPPPPHEAPPIHYPPNTTLLLSEQVGNAGAWVVTYRSQVSTTERDMEALEMNSPMWLLDCIFANRVKEKPVPRVTFVLKPQQGSSLPLLSETSRTVFANRSLRAKRIYTHIADKLNDATPSTQTKLTPDDLELFLAQKSELGVINGRTSVWQLRTLAENKSEVLVYYALKGESVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J007</accession>
    <name>A0A1E3J007_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030591.1">
        <property type="nucleotide sequence ID" value="XM_019177438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J007"/>
    <dbReference type="GeneID" id="30194564"/>
    <dbReference type="OrthoDB" id="2576078at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="559" mass="60601" checksum="B6DCF6BC7AF290DE" modified="2017-01-18" version="1">MVEFESGAGSSRRLPGGVKDGIRGAGSDFQPGSVPIQSQQAGESPPPSLPTPLRAPFELETPIRDDTGYISNDTRGPSSISPHDCAPMSSRLLDHGLSVLELDEMGISSAIGEQHDCNVKASLDEALASCIGIRSRCVEYAQGTKEGGCEEDPDATPKAEKATMDLRHQTRHSIHGSETTSPSMSSMCLSPASSCVSDSSPSETSDPTGSVQMSDSWSEKTPTKNEIRFMDGAFEEEREGQDEGECSTTIRITGFASGLFTSSSESDSEDEADDERDETRKENIVFSDDELNEWSDSDVEDSGDEEESGEDGDESGEEEGGEEEGDEGDAETRQRPHPLLAPPLLAEPCRPPILPSSIHSIFVAASFRSDSSSDNGDGSDRDDPDEDAALFLPQSPWLIETPPVAAASALPEELPSRSPPARNSPPHSQSSSPPSQSPPAPQGYECPPTPPTPRFVMTEAPALPVYEAHRPIPIRFPVYPCAYYASHYMSVSYSAQGSWNSNSNLTSNGPLSGRREVSETERLDEEWAKKEEEKLREEEEDQGRIRKYAQEYSIRAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B5</accession>
    <name>A0A1E3J0B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030848.1">
        <property type="nucleotide sequence ID" value="XM_019177267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B5"/>
    <dbReference type="GeneID" id="30194386"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="633" mass="70313" checksum="9075ED8F7A0F21FB" modified="2017-01-18" version="1">MLALLSWRYGRFLPLAVLIFLGSIFVLIDSSASSESTLPRASIYDYTSPATHCFWPADNSSRAGAASAQLKGAAGKGTVGKVKQWMGWQDGDEVDEDVAEMEDTPEGHGFAWDGQLPDVVPVSGIERYMIAHIEELQSGYDAEHDFKEYGLKPGNISLSAYTSELLQTYREFLVPPGTPPPVPPPAFLPAALSRLSLRPPIAPLPPRPNHVMTTEKSVDDLPWQFKRWKEIMPDWEIKYFDDKALKDWVNGMFGNTKASKIWETLPRQVLKTDVFRYMAMLVEGGIYTDSDSMSILLMSTSQILTSLLAAPIIHADQWGHPYNHKTSPLLTHLARILSISTSPHLPSSHPLSSFSPEHASDNVDEELGANLPSGKSAIYDGPLVDDGAELGPPSLVVSVESDAVEFGWKNWREVGLSRAVQITQWTFMARPGHPVFLDALGRTLRKSEEMAAKVAEAKKTGEEFIPETALEWTGPGVFSDCVYRYLISRYGFKPDDLIHTKDPIRVGDVLILPAGSYSSVSPFGDEKQRNWAASWHGFFGRWRGADPAVQEFERLKKLKKEAEEAEKKAKEEVAEAEKKAQEATDRAKAVEAEEQTVKEVASEGDGQEDQESSEMKKEEEMLAKETSRSVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0L0</accession>
    <name>A0A1E3J0L0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030716.1">
        <property type="nucleotide sequence ID" value="XM_019177135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0L0"/>
    <dbReference type="GeneID" id="30194249"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="17625" checksum="95DDBB131262915C" modified="2017-01-18" version="1">MSNSQKREKLDIESPEEREARLGQLLSSISTGAKPSDIEPSTPSNPLPSRPHAMPESDVLARVRAFLPQFQAANEDLLKRAEEDPDSVDIEKGQGQHIAMDLGLGVFDAPENPSNDMGPIIESTVPEGFQQRQDEESEDESSSDSDSEGTSSSSEAGESVSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J106</accession>
    <name>A0A1E3J106_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030876.1">
        <property type="nucleotide sequence ID" value="XM_019177295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J106"/>
    <dbReference type="GeneID" id="30194415"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="784" mass="87355" checksum="9910C43D39DD2F64" modified="2017-01-18" version="1">MSDISKPPIATQDEKYLGLDKGAFHDIDTHVAEVVYYSTGEGIHITVGETPKEVRAVAVEVDDEDESCETIRAYVLGTAVAVVGTGLNVWFGARQPGIYISPFLAQFFSHPVGAALAKLLPKRVFHLRGKTWSFNPGPWTVKEHAIVTMMATVSFPTATAIDIVIAVRQPVFFNDSDLGNSQGFRWLVVLSTQFLGLSLAGLSREYLVYPSNMTWPLNLAKVSSYPKEADPPVNGWKISMFRFCLTATIASFVWFWFTSFIFPSLTYFNWPTWIAPNNKKLAIIMGSMTGLGLNPIPTLCVIKLHSLFNPADTLHWWATLQTLIGSIIGLLVIIGTYWSNTWFSSYLLPNSNQAFDRFGAYYNVTAVLAPDKTLDVEAYQAYSPIYFGAGYNLVLIAYFASYSAVLTYAVLEHGSQLKHGIMTAFKKVISLVQRGRASEESHDRPQYDIHYAIMHKYKEVPQFWYLLILVFSVVTGIVMVEVYKTTMPVWGIFLCLLLAFVFLIPGGIIQALSNMQVSLVILAEIIPGVALPGRPYANMLFKLYGWVALIMALLYVQDQKLAHYLHIPPRSTFRAQIWGVLVSSIVSIGVLSWQFNAIPDLCEPGQKDLMTCPYYTTFYSSALMFGVVGPERMYGAHGLYKWTLFAFLAGAVATVAAFGIKKVWPNRYTKAINVPVIISGMMYFAPYNISYVWAGVPFAWFFMSHVYRRFPAWWAKYVYVMSIGATIGCAVSGVVIFFCVTYPGAVMPAWWGNTVYANGCDALGCPLLDLPDVGYFGPGPGEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J324</accession>
    <name>A0A1E3J324_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031233.1">
        <property type="nucleotide sequence ID" value="XM_019176758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J324"/>
    <dbReference type="GeneID" id="30193855"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="429"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="667" mass="71972" checksum="99EF8A45BF3D0B0C" modified="2017-01-18" version="1">MTSLNSVSGWYTNAYSGPFRTSRLRAPSLLPGARIPAPVQQTLVVDAAHNNSPSADDANPEGKDGVKNVKRRETVFGPDVGEDDEPGWGEGGKEEISVDVVKKWVEKAKADEGIHPTTTLQALVNLKRPSLLLQQVDQPQPKADKYEDITPYPTAAQSDSPTSPTSLLPTPPLHTLKFTYDATTPAARITLLLYPNPRPRPTIPEGGGKASFEEGEEEEQEPTVIYTGLHAGGFGQVFDLPKEWAMDLSSAIRIEEEDQTTKPEVKEEPVEQVQELNEQPEEQQGRRRFGIFGRRRGESDVEAGNANIEMTSPVTQSEEKEAPKQVEYGMRILIKIEATGPEGQHLKRRNAQLTHILITGTWVNDPNSGDDAGPGGKRVWVVKVARREAVIGSHTFLLKEIFGLSATSSTATSYPPTADDPYASTPNECIVCLTSPRDVVLLPCRHLVVCRDCAVGMVEFGAGGKVARREEAPATGTGAGGGGDGEAGGEGGTDTPATTLATTTTHRERRKKKVKGWYCPVCRQPYISLLRLALPQAKASEAHSHHELSRQPSRASVRTTRTTKSLAPTLPDGAERFLEGLRPEGADAELELEEGEDKEAGSGSVRPGWVGGAAGTPDVEKPEVEHKEIEESEFTGPSPTPATMETPSHPEGDVADEGKGKGWKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J391</accession>
    <name>A0A1E3J391_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031310.1">
        <property type="nucleotide sequence ID" value="XM_019176835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J391"/>
    <dbReference type="GeneID" id="30193939"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="227" mass="24514" checksum="737A4AA60ACBAE04" modified="2017-01-18" version="1">MTGQTPDEPVPHSPCVDPSRTPGIEVSEHTDNDEEAKQHQDINGTVMKKRLDHWKVISGNSRDLRDICHSASVLARFHFSGRWYSWGHPNAAQHMFQRVGLTQSAIFGWVNRDIASLSLVKESAAISALHSDGPTVDLALSIGPFLDTGSLCDVYSISPPNTAPRFDNFPPLVLKVMNPSTFDDAAGGVAFATGEQATEAWKTETGLYAGKLASLQGSIVPLCFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3E4</accession>
    <name>A0A1E3J3E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031342.1">
        <property type="nucleotide sequence ID" value="XM_019176867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3E4"/>
    <dbReference type="GeneID" id="30193971"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="81190" checksum="ACC912B61C01C119" modified="2017-01-18" version="1">MSSSISASSTASSTASATSSSSSIVGNTNSSSFKIVGICLAVGSGLLIGTSFVIKKKGLINSTKKYGNQAGEGHAYLKSWMWWLGMITMIVGEICNFVAYAFTEAILVTPMGALSVVVAAVLSHFLLKEKLTFFGWIGCTLCIMGAVILALNAPEEQSVTTISAFKKLFLSAGFLAWASILIVGSLVVIFYVAPRWGKKSMLPYISICSLIGGLSVSCTQGLGSSIVTSIQGDNQVTNWFFWFLFVFVVITLLTEINYLNKALELFNTSMVVPVYFCFFSSATLITSFILYQGLKASAVTLITMVLGFLVTCLGITLLQLSKVDPEALESQLDRRSTMLMEASRHQTGDVEKGDVVGMEDPGMDALRGGFGAVGSIIRARSVSRRLSSGSTLSNGGKYGAGGLSTHGMGNMPRYQLSDNPMPSDAMSQISMHSAKSPSSRSFMSSHAHFLSPNRTGNSRDDGDIVNMYQYDREDSHNLHAPPPPVRSYSTENYHHTYHPNPLYPPVLEEDEQGYENEVDSKGRYGSSRTKIYVDDAPDQVNSAPVLGKGSSGGGYKNPYDVYPARANEPKPMPIAKSQKSIGNIFHFPSGPDLSLDIPSHQRNRQDSSRSSRREKDQYPTLSKKDRNDAQEREERRGLVRSDSDGSAEMINSSPEGGDGDGGEGEVSDDDAMSRQSEPPSAISTRATIGRGTRVNLSQTDLRSERSGGSGGEPVRKGTKSSRSQARIQQQQGGSKAPRRLPDVPGFAAGPPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4I1</accession>
    <name>A0A1E3J4I1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031419.1">
        <property type="nucleotide sequence ID" value="XM_019176491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4I1"/>
    <dbReference type="GeneID" id="30193585"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63299" checksum="37CA39E396931CDA" modified="2017-01-18" version="1">MPSKESQDWDSLVAWFEECHVGFRMNIELRDTPGVLRGLVVTEDVKERATLLHIPAASMLNPLTLLASDSTSKVLSKGPNFSIPRHLFPQPSHVTSAANSSKRLKTSPAGTDSSQSQQLDTTELLTLHLALSRDPHKRYTSDWQVYLETLPKDFRPWHPLTWLVKPDPGTKEAVEGWKWWADLYENHASPTLKLKVAEVKKRYDADKAVILSTLRTEEPFKSHSLATTLTEEDLLWAWLNINTRSISIPLGLPGPTERMNHTLVPILDMINHSSDPSVTAPRVKQLPAPTPTPASSTTRAKKSHKSTSSDDWASHGTRYSRNGLHLVPGKIDLELVAPERKMAQGEEVMFEYGGHDNATLLAEYGFLEEPDGADDQKWLNLKYGELDVGWIVDELWAEKVGSLEEDEEDGEKGEKRKALEGIGCWGRVYFLCSICMALLTHNSANIIHAQPSPPHPSHSLLMTLRVLHLPQGSPKLTGIQQGYSTYVSPSNELAVMSSLEHICARVVQEAEKRLKNLKKLDKELKTEKGSIAERQTMLEMMEGLYTEEKVLAKNILGRIEAGEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4R7</accession>
    <name>A0A1E3J4R7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031523.1">
        <property type="nucleotide sequence ID" value="XM_019176595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4R7"/>
    <dbReference type="GeneID" id="30193690"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="412"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="658" mass="72928" checksum="51F047AA4A9D529B" modified="2017-01-18" version="1">MSRPSNPPPRAGTAKSKQPATAARRNPGTVPGLARTASSLRQGGVHPHTSLPAHLRGLNLSTPKIPSPLGMGTPARQLKQSLPARTSKTTEKHVLLPEDPQLAPLPRSPGDMPTMSAPPRRDSSGGIPGAGRSGYHPTMTHGDERSDAEKMTKREREENKLPRLTAYATAEGYRLKLLQAFLKREHGVSVVRVYDDCVYAVYNLPLLPGYGATTKVRSSPITKSPGGVSLMERMTMAEDLGYHDTYFPREDPTEATPAEYILSTSPGMEAGEELDAMAQDGEGERERRERGEEEALLEQVNAGVFEEIAEGITPLSIPEQQPSEVSEPEVGTQIFPTDGYTHIPSTALNPDDLPPASPSSEDAVGNTTYHVGYLDPPIGEGHKHVSHKEPQEQPKIRRRKSHGHLNNVAEAVFFSYGVSVFFGFREGEEKEIMEDCETAGAWQSPKSEDDWEAEEFHYVYDPDAESPRIYNDMFTFKSRSHLFKLSLAHAVAQSTRLSIYESVMQETLSLTASFPKELSITGHLQLTRREALKMTGRLFKLRMDVNLSGGILDTPEVFWSEASLFPLYEAIHEYLEISPRIQVLNDRLAVAGDLLEIIHEYIEERATHRLAWIVIWLIVVACFVEAGEVVARLVFHEIARDEGEYMLLKAPQLLLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4X9</accession>
    <name>A0A1E3J4X9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031562.1">
        <property type="nucleotide sequence ID" value="XM_019176634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4X9"/>
    <dbReference type="GeneID" id="30193729"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="41438" checksum="099E63439AA3CEBD" modified="2017-01-18" version="1">MSSKTGTDFWSPTYWSTRFTTETNFEWLVPACTLVPIVKDVVRELPAPPRIWNYFENGVEDGEEGFCGVGGEGGEGGEEVGGEEEEGEGEGEEEEEVVNILHLGSGTSILGTQLQTYLSSPSPYSSPPSPPPSPPSPFPSPSPPPPKTQASSIPKCQVYDADYVPLPSSTAQEEGRVPFLLVDALDLGSLYASLPLSKGRGVVGGGGWAGGEKGEGGGRSGKGGGRGRGRGKRKWDMVLDKSTIDAISTGPLLPPPPSPSSSPSSQKAPSAELGEGEEELPADPAERTLLNVGRVVRKGGRWVSVSYSSTRYDFLPFCPSPSPSSPATSSAPTSLPKSNDKEKYGWRVIRKEIVAMTSLPEGRLVRDGRGERVVYEPETGIWLYVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5K6</accession>
    <name>A0A1E3J5K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pantothenate transporter liz1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031590.1">
        <property type="nucleotide sequence ID" value="XM_019176662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5K6"/>
    <dbReference type="GeneID" id="30193757"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130207" description="Pantothenate transporter liz1" evidence="8">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17920" checksum="2D1692603ED5A3F6" modified="2017-01-18" version="1">MVFSTLVGVIIPAALGATPVHPPNRGTRWALFYLTSLSGVSAGATWTFVNETSRDDPEKRAYVGAMMNAFAYIFTAWIPIFTFPTSKQPYVAHGMFATSGFAAVALLTALAIGWMHHRDLRKAARLGEQGAGERGGEVSRVGAEKEDDGDGSEKGDASRKTPVLEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J685</accession>
    <name>A0A1E3J685_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031598.1">
        <property type="nucleotide sequence ID" value="XM_019176188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J685"/>
    <dbReference type="GeneID" id="30193279"/>
    <dbReference type="OrthoDB" id="2414509at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="43471" checksum="33656C99624602EF" modified="2017-01-18" version="1">MPAPPSTPATAKRSNKKTDGDDASGWRWKHNKKNSTICVGPDGRTGEDYLIDWMSVPENWAAYSDSNNRAKFAATVIYKWLLKKKIKNFDKAKASGVQDRIQKIKKAFDEALAIQKPTGQGVTEDDLARGIETWEAKIKENCPFFFTPLPSLKDRNANITEQSSVHQMGNREVSITPSMARHVSSRSDMEEQPVGMEAEDVGDDDVFSVRGTRANSLSTDITSNHGVADEPTSGARGAGSLSNRSRARASLNAQDTPTSDKGRRGNANLNEQLQGLFKDHSTANIKGRKEIAEQQSQAALALEKYKVAEQARRFEGELAMKNKRLKVEDTRYEAKLQIEQDERKLKRKRDEDDANWRNVKAQREELRAKDEMAAKKWEFERELIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6L4</accession>
    <name>A0A1E3J6L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031401.1">
        <property type="nucleotide sequence ID" value="XM_019176473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6L4"/>
    <dbReference type="GeneID" id="30193567"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="192"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="308" mass="32302" checksum="956681C371DD00E9" modified="2017-01-18" version="1">MPPSLSAPMARCIPRSARCVSSNTPGGDADPAILLRQVMRNVAQPVAVAVASVPPSSPLAGVAAYHGTTLTSFTSLTLHPRPLVAFSLRLPSRMADCLRPWRTGGGRDPGLPEYEKAGSVGAASGDSGLRLPPKSDLPWPLSKLPMPEDPPIWAQSLCSQIPNPTSPPSNPSSLPPSSKMVGSAKPVPPTPLTISLLSTSNSAIADALAQPRTDHSSIFSLPDTWVSPSSSSPAHPPSLKGCVGSLQCQVVGSVMLRDLCEPGEVDGAGSEMFICRVVGVEMDSEVDEDSLLPLLHWRRKYAGVEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J750</accession>
    <name>A0A1E3J750_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_04379</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031426.1">
        <property type="nucleotide sequence ID" value="XM_019176498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J750"/>
    <dbReference type="GeneID" id="30193592"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="251"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN95761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="403" mass="44386" checksum="B1E1DE2AA19B61EF" modified="2017-01-18" version="1">MSFSRSSASALKQALRTTAPRASRGAALRSYSLLTGAAPRAMATRLGATRGVKTLDFAGTKEDVYERADWPLDKLQEFFKNDTLAMIGYGSQGHGQSLNARDNGLKVIVGVRKGGESWKQAQEDGWVPGETLFDIPEAIAKGSIIMNLLSDAAQSQTWSELAPLITKGKTLYFSHGFSVVYKNDTNVEVPKDVDVILVAPKGSGRTVRTLFLEGRGINSSIAVYQDVTGQAKDKAIALGIAVGSGYCYETTFEKEVYSDLYGERGVLMGGIQGMFLAQYEVLRKNGHSPSEAFNETVEEATQSLFPLIGKYGMDYMYNACSTTARRGALDWAPRFKEANLPVFEALYKSVKDGSETRRSLEFNGRKTYREDLQKELDEIDNQEIWRAGKTVRALRPDANKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J751</accession>
    <name>A0A1E3J751_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-dependent RNA helicase DOB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031751.1">
        <property type="nucleotide sequence ID" value="XM_019176341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J751"/>
    <dbReference type="GeneID" id="30193432"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="152"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="387"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN96505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120050" checksum="5741B01376F40016" modified="2017-01-18" version="1">MPDSTKKATKSKSSKQNLNPEKKKRSKTTPTPSPRPSKSAKLVEINDDDDPMAALENEQNEDKGPMEALEEEQIVPKVADEYEVQAEREIAAAKDSLDSSGDKEPLKLVHQVRHQVAVPPDFPYVPINQHKRLDPPARTYKFELDPFQYVSTSCIERNESVLVSAHTSAGKTVVAEYAIATCLREGKRIVYTSPIKALSNQKFREFSETFGDVGLMTGDVTIKPEASCLVMTTEILRSMLYRGSEVMREVAWVVFDEVHYMRDKERGVVWEETIILLPHSVRYVFLSATIPNSMEFAEWITQTHEQPCHVVYTDFRPTPLQHYLFPAGSEGIYLVVDEKSNFRDDNFQKAMASLAQGQGEDPADPNSGRNKKGKTKKGGAMKGETSDIYKIVTLIMRRNLNPVIIFAFSKRECEDLAMQMQKFDFNTPDEASTVAQVFENAIGSLSEDDKKLSQIEGILPLLKRGIGIHHGGLLPILKEVIEILFQEGLIKALFATETFSIGLNMPAKTVVFTSVRKFDGKDFRNLSGGEYIQMSGRAGRRGLDARGIVIMMCDEKIEPEAAKGMVKGQADRLDSAFHLGYNMIINLMRVEGVSPEFMLERCFFQFQNSMSVPVLEKQLKEAEVERDAIAVEREDEIEEYYELRQQLKERGQDFQAVITHPAYCLRFLQPGRLVEVREGEKDFGWGVVIAFNKVVNPRGRPPIWTDQDPPQKQYVVDVLTRIASGSSVPKDRSASELSPPAEGDKGDVAIIACSLSTLQAISQYRINLPKDLRSQQDKNAAFRAVGEIKKRMPDGPPLLDPIKSMGIEDKSFKDLVKKISILENKLQSLPVTTSSELPRLYDLYDRKQQSINTVKSLKRRINSVHDILQLEELKSRKRVLRRLGFTTADDVVEMKGRVACEISTGDELMLTEMMFGGTFGTLTPEQCAALLSCFVFQEKSEAKVRLKEELATPLRTLQETAKRIAKVSTESGIALVEDEYVQSFKVEMMDVVLQWCKGAKFSEICAMTDIFEGSIIRCFRRLQELIRQMGAAAHAIGNTELEKKFGESMDLLERPNTVVFNPSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J917</accession>
    <name>A0A1E3J917_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031822.1">
        <property type="nucleotide sequence ID" value="XM_019176412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J917"/>
    <dbReference type="GeneID" id="30193505"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="559"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114787" checksum="9EE0D9F93814E922" modified="2017-01-18" version="1">MTTPVLAAQSVTELIALKAKTQPDDPAVHTGAAEFGQELQTLTYLDLSKAVDRLAAHYASLKIQPEVVTGDLPPERIVAVLTTSSINETLLEAALAKLGLAGLLLSTNNSTAAIVHLCKITKSEILIYEDKYEATANEARDLLQKEGIDIRLVPETKFPLWGPKGVREADIPPYPARLTPQQEAGRTVAILHSSGSTGFPKPVAITHYALLSNALRLLPVSTFLALPLFHAFGHIAAFVCLYHGKPLTIMPPNISLTSVNICRVIRESPSPPVQQYAVPYVLKLLAETDEGIQTLAKSAAVIYAGAALPDNLGDRLVEGGVNLVSIYGSTECGAVMTSFRDFKTDKGWNWFRNEGPIAQYLEALPQGSNTFEVVIRDGWPGKVTSNRASDNAWCTSDLMLQHPEHPTWFKYLGRMDDTLNMLLGEKTNPVPIEMAIRGHSPLIQECIVFGDGKPQVGALILPSEQGAELGKDPKAFLDAVWHVIEQANADAPTHSRILPEMVEILPYGTEIPVATKMSIIRPACYRKFADLIDSIYERFERGSGEPKKNITTKPELESFLTSTILSTISDKKTQAPGKEDVKAELGVDTDLFSFGIDSLQATRIKNAITKTLDLGNAKIGQNIVYEYPSVGQLAEYLFNARQGSGADESPEKVYAKMWDMVDRYARQLSKEELVTISSKGQVVVLTGATGSLGAHLLDQLTRRHDVSKVICLSRAKSHADSLRRLQDSLAQRHRTLTPAAEAKIVSYAADVNSEDLGLSPELYEYLKNEATAVIHNAWPVNFVISVESFDEHIRGAFNLLDLTLKAPGQVKPAFFFSSSVSAQLASDVAVTEVFPAKAETAMMGYGRSKWVVEKIMERAGKETKARCGVLRIGQLAGDTENGIWNETESWPLMFKSVNELHALPMISEAPSWLPVDQAASTIIEIVFSTTFASKPSSASVYHIINPHLTSWSDVLAGLAAGGLEFDTVPQTEWVARLSQSNPDVAVNPAYKLLDFYQARFGSGDDIPELEFKVERTREESETMRNQVKKVGPELVALWAKAWIESGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J936</accession>
    <name>A0A1E3J936_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031966.1">
        <property type="nucleotide sequence ID" value="XM_019176053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193140"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1342" mass="147219" checksum="41A0C629E477CB41" modified="2017-01-18" version="1">MPAPPLSLLQSLSPRIAVLAADDVTTSSEANGCRGLHELLRPWEGATDRVSILSSTLAPTLHPTFPLRFVAWDSVYLNPALSSPDPHLLVDTISSFVAAKSPDEEQHYPLTRSLLLSSRPLAPYETFNHPVGILFAVSTSTPDPLGTLSKLQARTVGTGSQNVPWLDGVTVLKFYVVVHDVSRMGDDMAPAHELLANVKRAYGPHSTLLVINSQTEHRSAPPSPDTSTHPTIPLPRPFTPEDGNPSALSQVYASALSSLTLSPMSAAAHLLKSNDGDQPLATPGKPSRRKLYGAKLTAEDTQRLAALVRELVVQSLIPWMEARIREWNEVYHANRRGITGRLFGAGRKLFGSRPNSPATDAGAAGYNAAAGYYPLTAIEGLSRRLADFAFMLRDYRFASNIYDSLRKDYAQDRAFRYATAATEMYGLCLLLSHSFFNPSVSPNRDPIPFTNLHHTEVTSWLEQAVVSYHRSGPASQIQVDALRITMLYYEAWKAVKEWRGVGATLVKGAGEADEVPNAVFIEEAAAADLRSGKNGRGKRRSAFHLVLAARRYETAGLKTYSRRCLERASEIYRTAPWSAAQNHIEFSLGRQAYTLGQSDVAVEHFLRLLRKEDTTGLGSQSGPLQDLELAYEQLQAHPDLLKKSKEKLQLPTAIFDHKQTRISAASVSPVVFGTMRQEWAHLEKQALSRWNRKGKRPAALLSDDKKLVVSVGESFTVELTVTNPLDSPLLISKLELQFDPPSAVEMESYPDITLDPYESRAIFCSVAVPTSYPSSGTIKLLSVSFKFNGFLPCTQNLAKRGKRLHATKAQRLQPTYAEDTSLAVFLSAERPRILAELVDLPENVYEGEIVESAIRIRNVGNNSVGEVSMIWSEGVLVSRKGTEHQDASSRIANHISLNQLESLYQEPLSSGEEVDIPISFSGLSPGALDVRGLLVYSDEQGKKETSATVIHHSLNIHPLAALTTKISPVGKTLGEYAVLVEAENVSAETVKIESLAGAAPAWDVQEMSFESHLLPNQTMRARLTAKLNLDNTFDVTQSATVKALGELIEGRAADETRADITPTVSLLGGPAAECLPFLSASRRAYRLTYLHTHFPTIPIDSLSALFPLFAPLELDILIRYSISSPSKTSVRRGYLTLHALRLCPDFSAVEILKKQVEEAIVSGTRQTRTMYEETGRLRKLLLDSVLDGCLGQEENPVGVEVGVEDENEDGIIEHDFREGPCSVPINFTVRNHSPLLPVRYIITLPPPLPQHASNTSGPASLTSPRFIGQLSYRGTLAPVSSAVVQSSLWLSDPALVNVNGWKLEVETGQEKSIAEGKWETRKGWRSEGESKIVEVAEVRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B1</accession>
    <name>A0A1E3J9B1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032041.1">
        <property type="nucleotide sequence ID" value="XM_019176128.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193216"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1315"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="378"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="794"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1083"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1405"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN97439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1656" mass="183110" checksum="F8CC809A52C8719B" modified="2017-01-18" version="1">MDPHQLAQAALSLPPLLHVAKAKPHPPPLIFRHSLFLFPLFVAASILILLLSWAIPKLYRATKSKFSKHEYEAILARDDELGVETEAVEVVAAPPAMPSGGLLDDFKKHVRSMREYGTVLFALEVVRTLCLCALLGLSIYATILAESPVENSTGLGDVDILKKHWKGKKGKKRKHHHKSTVDDYSSLEWGEFGVSGFYLYTLVFSFLLLTLRPATPLRRHLIAHLDVLLLLGFAVYAYRDYWPLFTFDLESADIHNAITWSRAVILTIAAVVIPLIRPRTYTPVDPENPTPPGEVHPEQTAPILSYIFFEYMTGLVWKAWKSPSLPYEALHPLADYDRAAYLYNQNMDKLDPVKRKAKGLKPRNLVILLASIFKKEVVFVCAMTSIAAILELSGSVGINQLLDYLEKNGKGHTLRPIVWIIVLFAGPTLSSMALQFYIFTTTRTLVRTEALLTQLLFDHSLRLRMKDQVDDDREKEVEEIDNEEAVVPVVTVEEIVDHAPGAPEELLHRADSETEGETAVAPSTEATEVGSSAGSDKDKATSRKAAADAEAQKTKGQGLAGKINVLMAADIDALIEGRDLALVFVYTPIQFVLCIALLYRILSWSSLIGMLTMFITLPLPGLLTKLNAQFQRKRMLATDSRIDTITEAIGALRIIKMFGWEDRIKERVAAKREDELTLIWQRRLMTLFTTLLNTVLPVLTMTVTFAVYTTIQKQQLTAAKVFTSMTVFELVKGQMGMTFYLLNSIVTAWVSVGRLDKFLHEASFQSEMIDEYAEEASTDDKPEGLLKAEEDGVVRFHEATFTWDPNPSNKNDQGFKLVIEDAAFVKGKINLIAGPTGSGKSSLLKALVGELHFHRKAGSFFHLPRSGGVSYAAQESWCSSDSIRDNILFGEPFEEARYWKVISACGLEPDLKLFDDGDHTEVGEKGITLSGGQKARITLARAIYSRTAVVLLDDIFSALDTLTSRWIIDNLFTGDLVKDRTVLLITHHLHLIAPVADYIITLNEDGTARSQGSVNDGALDQGELEEVEAAEVQEIKDAEAEEKKEEKKPAAKLIKDEEKSEGRISKRALFAFFRTFGGPVFWFLYFGLLVGGQAMSSFETYWLGRWARAYDESESPKDVSVAFYLGLYFVFVLIGLVELAASAILFYIGAVKASREVHRRLVNSIFGAYMRFLDSTPVGRIISRFTKDMKSVDGSFTETFANVADVTVGLALKIIVVVSLVPLFSLPAVFIGLLGGTIGEMYIHGQLSVKREMSNAKSPLFSHFSAAFNGIVSIRAYGAQNKMRNEAQRRADKYTLISKSTDVYLSFNFNRWVTVRLDMLGGLFAACLAAFLVYGPRLDASTAGFALSQAISFSSMILWWVRMINEMEVQGNSVERIQDYLDIPQEPAFDDRKQPSAAWPTSGEIVLDGLSAKYSNDGPIVLDELKVSIKSGEKVGIVGRTGSGKSTLALALLRMLPTTGKVLIDGVDTAKINLHALRSNVTIIPQDPILLSGSLRFNLDPFGEHDDAELNDALQSSGLGATRQSGISGSVTPQRLSLDTHISAGGGNLSQGQRQLVALARALVRNSKVLILDEATASVDFDTDTLIQQSIRDLPSSCTVLTVAHRLSTVMDYDKILVLGAGKVLEYDTPKNLQQNKESYFAKLVQAMEGKDVDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9E0</accession>
    <name>A0A1E3J9E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="12" type="ORF">L198_04266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031797.1">
        <property type="nucleotide sequence ID" value="XM_019176387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9E0"/>
    <dbReference type="GeneID" id="30193479"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="515"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="933"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="935"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1042"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1095"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN96551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130754" checksum="A08919F762782514" modified="2017-01-18" version="1">MNFNPLNLLPLPPTSLDPKPIPTALTVDPFSDAVWVGTSSGLVSALCSPLTLTRNVQFPAHGYKSARGAGFGHPAVSAVKEIRVTDRDVWTLTEGGIGGRKRGGAPKWTVSEPTRTLQTMAPNPTNSHELLAGGSGSLLLANTARGEMVRTIDHSSAVVKLAPLHRTVLAAGLSGQVTVLDPRTGFKAAQNVNSVQAHVGGLSGADVQDNIVATWGWTHLQGHPMPDAHIRLYDVRALRPLPPIAFPSGPAFVLLHPTSSSHLVAASQQGMLQTIDMSQGPSATVFQQLDITSYLTSMALSSRGDYLTFGDADGQLHVWTTQETGENAALDENGALALPPFNGYDGVKPDWPDPVEPPPAIDWTSNTPLNVVGMPYYTESLLSNFPPACYATSTSPLYNPPPTIPSSVLSSMKMVDFVGYAPNPKELRGKRYVLRATPGAENRAKGRGRGGHRRDSEPRFRSEKEKNGKHSLKDEEDGLTGDGEIPKYYRKVEIKYSKFGVEDFDFEFYNRTQYSGLETDILNSYTNSLLQALHYTLPLRAVATAHICVDCKKEHCMLCEAGFLFRMLEDAKGRNCQASNFSRAFSATSQAYALGLMDDRQNNKSTAPYGSLIQNFNRWLLSSFSTESVIGGETFDIRKTNAAGDSEVAVENLSIKNKPSAIDQVLGVELTTTNVCKNCGYTTSRQNTLHAVDLLYPKKVNHRLTFPDLLRSSILRESSNKAVCPSCRAFAPLESKRSLSSAAEDDLPPVMSVNAMMTTPDVFGFWKDRDSERMKREGKEGARFLPRRLVFKNGGRGLEIGRDGDGVGYAVRSMVVQIQDSAENAAHLVSYVKIPATEKSEPQWVMLNDFLVRPVSEAEVFSFPDQWKVPAVIIFEREDVDTLLDLDRLPKGLDKEILFKDVSIARNRKEDIIKHKLLRRDEMPHRGSLVAIDAEFVALQQEEMEFRSDGTKNILRPSHMSLARVSVLRGEGEMQGKPFIDDYIHTSEAVVDYLTEFSGIKAGDLDPSNSPHTLVPLKVAYKKLRLLVDLGCIFVGHGLSKDFRTINIFVPPEQVMDTVLIYTIPGRQRKLSLRFLAWFLLHQDIQTNSHDSIEDAHYALLLCKLWMDHASEGDIAFENLMEDIFAEGRRLGFKPPSTVGLSADLPVSPGKVGAEPSLGVQAAIAAGLATPPSKEALSLSYTPAGSPSARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JB66</accession>
    <name>A0A1E3JB66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031958.1">
        <property type="nucleotide sequence ID" value="XM_019176045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JB66"/>
    <dbReference type="GeneID" id="30193132"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="275" mass="30705" checksum="AB4A9CE04D4744D5" modified="2017-01-18" version="1">MAALQTPEEKLAMPTWGSYLYQNYLQAPSPDTVFDWTDPSVSIPPPPAREEYAFGLTNPSVWPSASGQSPKSVKPEPVSPADEQSLRQLQDVYKQAYFPFPATGIATSLLTQADTPASALPAQLGSSESLNVVDQSLTRSPSPISSHIVSPHASPILRHSSTKRETRGRRRIGSAAIKRSHSLHSDSEFSHHSPDEHDHDEHEHEVPEGVERDGMIWGMKVEDYRALSARERKRVRNRISARTFRAKRKEHLSSLEHGLVKKRLAKFETAYARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU6</accession>
    <name>A0A1E3JBU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032186.1">
        <property type="nucleotide sequence ID" value="XM_019175696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU6"/>
    <dbReference type="GeneID" id="30192781"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="173"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="69487" checksum="CCB94F951F4DC8DF" modified="2017-01-18" version="1">MPRIAARTETYDTIRECNRHYRAKRDHILHMLGKASYIDGSQFLITFISPKGEIHSFQSTLLKEPFETKQKVDEGGGLLHMDSLKYHAAQVKQKLKQRREEEGKSNAQIVPGAKGKLLPVGSDDEDEDDVEDDDADDIDPDRTLVEPPTPAVASSSKLPSDQDKTVFTIQPDDIVPYYEKRFSSVQQEVCKQVAKAWIKVVEPKKQSRFPYNKGDKSKPKWWPKSIEHRAPDHLTKEQRLSLLIHMLRGNLAKVADLELSVATIMAWLPADKLEIIREICLVARADEVWRASGKTDRPLVLTIPDSLREVWLAGETLPRYTNEAPLGAAAVRAATEGAAVHAAAMAEVQAELSQAMSSASAPPVEFSKSSLVEKTKKRPSPLGMSDKLNARMPAPKRQRSTPSINYTPVHPNDYNWRPQGYMPNHQPPFTPLGLHLHDPNPYPPPFSHVPLGPQHHQAPPPHVHGHMGEHVPRYHHVPPIMTRHHSMGEPSPIYLTPAMASPMLEDFSNQQGEASSFMYIDPSITQPGSAGIDPSSQTSSTSLSAPTPTSAPPALSQPIPGSADFSRSGSQQGYMQQQQMEYLEAHTPQGYEYLAPTPQGDTGFERFYEGESFDYGMPVVSDQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC11</accession>
    <name>A0A1E3JC11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032275.1">
        <property type="nucleotide sequence ID" value="XM_019175785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC11"/>
    <dbReference type="GeneID" id="30192870"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="78" mass="8135" checksum="48D9AEE4A822CF66" modified="2017-01-18" version="1">MGNGAKAQQKRDRNAKDAKGAGVSQLKTNAASLTIQCDVCKATFQGTSKIPVLQQHVDSKHPKSTVAACFPKVPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC44</accession>
    <name>A0A1E3JC44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032083.1">
        <property type="nucleotide sequence ID" value="XM_019176170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC44"/>
    <dbReference type="GeneID" id="30193261"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="6">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="37061" checksum="6F013BD3C6258027" modified="2017-01-18" version="1">MLASRTHLRLPLHPRFARPFTSTLSPLSSQPNHLQTLLQNRELQQSDAENELRWITSWVREEAKGMMKKRKLPPVEDERIEGFVQRRAEGEPLQYILGSTDFGPLTIKCKKPVLIPRPETAHIFTLLSSSILSSVPSFTSRDRPSSPLPVLDLCTGSGCVGLLMAHENLMAEVTGVDNSPAAVALAGANVRDNELEERVDIRYGNVFGPPQGLLGGKGKVGVVVSNPPYIPLHEWEQLPKGVREYESPAALLGDGKKAGEGLAFYERIAEILPELLLSEEEMEGKGWKGIPQVAVEVGLGQARKVEEIFKKSEVVGRTEVWKDQYGVERMVVGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCX5</accession>
    <name>A0A1E3JCX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032397.1">
        <property type="nucleotide sequence ID" value="XM_019175907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCX5"/>
    <dbReference type="GeneID" id="30192994"/>
    <dbReference type="OrthoDB" id="2589196at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25479" checksum="BA831B622E57EF6B" modified="2017-01-18" version="1">MPYGYQLPYGAHVIVLFLSLLSSLVLIILCTFSSPFISGISWLRNPSSAGDTTFGSFGWCSPDYCLPNRVAYEYGQQVNRALTGGMMLWPIAIIFTFLTWLAVIPLLFVHDNRALRTVGNRTFFVIMMSTATLVTIVAWLLSIYGWSVAHRAFEIAGVETHTGSAMWLGLTAALCMLIVFVLGWPAEAWDGTSTRANGGAGARGLPGPPGAPGVPTNGYYHYKKTTREVVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEM6</accession>
    <name>A0A1E3JEM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032415.1">
        <property type="nucleotide sequence ID" value="XM_019175312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEM6"/>
    <dbReference type="GeneID" id="30192393"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="101055" checksum="81F2B1F446E44D83" modified="2017-01-18" version="1">MAALTARRPPNPPRTSTAPTGSSLHLTLPSSSSSSALPPKDTDHRHLSSKFKHMFENQKYAIFNASVTLHEVGNVPQLEGEFAVGWRFRGKKPRGKESLELHEKHLGPLPKPSLPNLRISNPSSSSASVKTNSTSSSIPAPSTSGSLLNPEHHRSQKPHKLFSLPPPLHLGHHAPDQRPEKKSSDPTPLKQVLTSSDMEGGHMQQWPMESPGIMEELDGDYFEEPSGSSGSWERPESAGGTSSGSQGSISVVTGGPQVNVHRASMNSPSTPILRDQQNRAGQLSIPFPGGGGGGGKEGGLPAPVRSGTMPSHTPYLDAFEKDSLAPGPPGTRRTLSANTAATAETSSFANSFHPHSRDFEKTRLPRVRSTSGPMPTLGGGGGERDAELVSTHRKGETPVRPLKAHTCKWDFELHHTLRIPLFKPNTNGAGGGGGKKGDAMLLGNGPTSESGLELTILQYPANANAAGGGGVGKSVQASARASPVPSMIGGSNPSVVASGLEAVTAGKKDGRKLDRTPVKFGTVNIDLAPFAAQILASHSGGPTSASGANGPGGGGGGRMTRRFLLKGSRTNATVKVSVEMEWMGGEANWVAPPMQEGHHVMGVNELMVDNHDSHRPDLLLAKTPSASSSDSTPLERTSTNMTTLSGISNYSPFSHHNTPGQSNHSLQLTRTRTGGTSGTLGTLASISAGGGGPYDTYEHHLHAPSPSPTRSPRRKGKRVELDLEGTTPKAPSSSRMGSPVRSEPDRDRGRRHHSTRTPRKPSPSPARSLLNLDVTRPSPSRQNTHSPLPPPPPLIPSLHDMQHTPNHRHHTHHLRPGHTPSSKHTDMHDLPPETIIEAIFNPHPAKEAGPFTYVSLNADGHPEGYSMGLGKGEVEERMVRDANGDEERYAYSRSGLGVDLEGGVDGKGKMGGGGGHKLGWRMRGRAKAERGNTARVVSAQGCGGKLKGKEMKSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEW1</accession>
    <name>A0A1E3JEW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032439.1">
        <property type="nucleotide sequence ID" value="XM_019175336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEW1"/>
    <dbReference type="GeneID" id="30192417"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="415" mass="45024" checksum="5137772C78BA364A" modified="2017-01-18" version="1">MSGAEQRNERMLEEILRLPGNDNCADCHSSAPRWASVNLGIFLCVGCASVHRKLGTHQSRVKSVTLDSWSRDQISTMRSIGNTASNAIYNPNERLHPPPSSYGHEERDSEIERYIRKKYEQCAFKGGASARLDGRVEPTSLNRAREADGRLQAGAAGWTFGKENRRNPELNDIVMPRKKERDLPPIPVSPSASSPTGRAPPRARPVRSPSAQNVASMRPAPAPPSEANLVDFSSASTSTLPLQLNVSPSPQPQQPQYIPIQPTGFSTSPSFTPQFASPNGMMSNYLSPQPSPSQTFNNIQYSPQPQQGYGHHLSTQPSYPTLQQPQMSPGFQSQQAFGNGMMGGQQMGQMQMGQGQFGMGMGQQGMMNGSSNGQGQMGGYGQMNGIGQMGQVGQMGQMGQMGMNGMGFQQGYYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF52</accession>
    <name>A0A1E3JF52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032393.1">
        <property type="nucleotide sequence ID" value="XM_019175903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF52"/>
    <dbReference type="GeneID" id="30192990"/>
    <dbReference type="OrthoDB" id="2574168at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="363" mass="38808" checksum="B39D25C9EC233F2A" modified="2017-01-18" version="1">MPPSLPSNHPKSYSPLPGESNNARASPVARNGAVFYNQAASSIASTSTVSGDLPRAGMALRNDSEETLSPGGSRKGKKRAVYDEGVDIGDVQRPSYKGKERAWDVEQQHVPLEDPPANGVQSYPPISEAEEEERQIQQHLSRLAAKDTARRLAARNSKMLPASPAPTTSPRSSGSFSLRRPLSILTSAKRSSVMGSIDGILGRREEPVGELPMTRPQSSNAAYPNPYDSQPPLSPVPRPIASPISPTTRSPFADPFPPPPTLAGNERRPSLVTGVSTESPRAGARSLTSSPAISPTEETGFAYGGPTWRGGQAARGQPVEEEAPRRGPDRWWHALCAWGDDLDGGHDVSESDDGQKGRTNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF76</accession>
    <name>A0A1E3JF76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032596.1">
        <property type="nucleotide sequence ID" value="XM_019175493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF76"/>
    <dbReference type="GeneID" id="30192576"/>
    <dbReference type="OrthoDB" id="2565167at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="40455" checksum="45EB76728A44699F" modified="2017-01-18" version="1">MADLISDISSAAAGITTNPASSTADVSTSDAATTSQAASTSAIASSSAAQSSTVQSSAQTTSEPATSSAVPTTSDGGDSGTSQTSQTGSASPSSSPSASTSDGGDGATTSQAQTSNGATTSQGASASASASGTSASPSASGDSTTVVSSGGGMVTSTVPASASSSSGVATTTGSDGRSTVYITMTNSDGVVTVSPTATVDSGSSGSSSSGSSNHTGAIVGGVVGGVAGLALLAILLWFLLRRKRSRRDDFDDMMFDPGRPENQAPIDLGPDGGAPTVEPYYAPGVASTAASPEMAQYPRSAATTSDGGYGAVSSGGPSTAGFAGRGAGGYDYNMEPMPMPSANPTGVESPAAGLGTMGAKQREAQQEANRYHVQNQGYQGVPGSSGPMSPTTTDRTGVTVHQDGGAVEDEYSSEIPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHE7</accession>
    <name>A0A1E3JHE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032428.1">
        <property type="nucleotide sequence ID" value="XM_019175325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHE7"/>
    <dbReference type="GeneID" id="30192406"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="70"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="343"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="603" mass="67761" checksum="5C039C7F3DAE2416" modified="2017-01-18" version="1">MSDKLTRVAIISDDKCKPKRCRQECRRSCPVVKMGKLCIEVNPTDKKAFISEELCIGCGICVKKCPFEAIQILNLPTNLESHVTHRYAANAFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDDPPEWQEILKHFRGSELQNFFTKVLEDDIKAVTKPQYVDQIPRSIKIPNMTVGKMFDRQSETGQREQLETDLELTHLKDREVSQLSGGELQRFAIGIAACRTADVYMFDEPSSYLDIRQRLAAALVIRGLVTATNYVIVVEHDLATLDYLSDFVCVLYGVPGTYGVVTMPYSVREGINIFLDGMIPTENLRFRDESLTFKIAETADELQAPKTRRYKYPDMVKTLGDFKLHVTAGEFADSEILVLLGENGMGKTTLVQLLGGKMLADGVTDKIEMRVSMKPQTISPKFPGTVRQLLLKRIKGAFMHPQYNSDVLKPMNLEPIMDQEVQTLSGGELQRVAICLVLGVPADVLLIDEPSAYLDSEQRIHASKVIKKFVMSSKRTAFIVEHDFIMATYLADRVILFEGQPGKESYARKPEGLLSGMNKFLKSLDITFRRDPTNFRPRINKMDSLKDKEQKSSGAYFFVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI28</accession>
    <name>A0A1E3JI28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032736.1">
        <property type="nucleotide sequence ID" value="XM_019175004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI28"/>
    <dbReference type="GeneID" id="30192076"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="236" mass="24531" checksum="5F1514A8A4F1BA0B" modified="2017-01-18" version="1">MAALSVRNAMAARYSTLLSMTIRALEEETIGHTVINGDFSSSFPFTPFSSASNKGQAGESLGIIPAQDDSHPAAGLMSNHPDGIFFKDHIQLRGMGRMRDVPPGTGGLAGVFGDGRAVEEEARLEDVMDEKRGFLGGKRRRYSEAGGGSEYGRSSVSSVPGVPLSGKTNTQPLPHNHPAFSPSSVSSTTMPTAVSVTAYPVPPAVGVADLSGRPVDGGGSAGGAWSEQMGRDWPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIM0</accession>
    <name>A0A1E3JIM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032867.1">
        <property type="nucleotide sequence ID" value="XM_019175135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIM0"/>
    <dbReference type="GeneID" id="30192213"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="267" mass="29454" checksum="CC143D016782A228" modified="2017-01-18" version="1">MNPINHPGAPYGDPYRQAAQHQAQYPQSYNYAAPPNMSPGGLHHGAPPDLAAIARQGYLQQQQKLAQMGQMGVPGMMPNRGGVPGASQPQGYNMGITQEMREKHAREMAMREAVLRDTVAKDAAKKKSRQLKGTPAQQMLPRQGGGFQPPMSSDQYIKNAMTSPAVPQGEPIEPWADSLDELDPRELAMARFRKRHEVIGEIFGPETVKEIAEATKDFDLWSGLDGEALQEKVVSLEQETLDLEEKLATEPEAFKKRLTDIDVGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM56</accession>
    <name>A0A1E3JM56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033155.1">
        <property type="nucleotide sequence ID" value="XM_019174776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM56"/>
    <dbReference type="GeneID" id="30191845"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="211"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="927" mass="98189" checksum="BB37910E586538A4" modified="2017-01-18" version="1">MDSRPAVRRPRATKSPQRRVESKLAIWERISRRQDETNSVPASSSWSSSEVYRAAEVTTVSGSDSSSASDFTTSYDPSATSYTAYNATNALSPYSANSTESLTKNATITSTSTCSSSSSSARTSSRSSCTKSTRTTTFTSLWSTSKSKTATGTASAATSTKSAYVPGVMLNMTMSGDSDTQAVYGVEVEMGHDDDDGKRKRKRGIGWGMGRRASYAKDWKNQMVNLQVDLGSSDMWVAVKECSTSDCNSAPTLFNEDLSLDSDTTANITYQTGAVDGTIYWEQLNVGDFSIGYQAFIAATAVTNENLKGGNFSGVLGLSLPAASSILAEIGGTTGSNPDGATFLDNLFGAGSSAPSERLFALSLSRREDVRTLSTFGIGATSPLFCPSPCSPHFVPIVAQPSLGSTGYTHWRVQIQSLSVTTWSDEKSGTGATTSKVALGNSKVYSTKGSPLAVLDSGGVQILVGSRNYAEQIYGAIGVSMSSDGLYRLPCSKQIALAFNIGGVDIPVHPLDMSYVDPSDLGQSTCIGMVQYSSNLGDSGDFILGSTFMKNVYSIFKYPDTQKHVTWQPTVGLIPLTNASIASQDFYSVRVLHESLSTVSTTQATNAGGSGVYNPGSGTGTGSGSAESGKKASSTAIIAASSVGGFFVLVVVAFCAWWFFLRRKFGATGSVPTPDLKRRPSTSGHKSDHSMSTLRSKKHDYTNRQKSIIDGYKDWDGDEWVSGTEGGDSIRLGYIPEALEEGDDEGRQTRAVARSSRSLTVRSSSHRSRSIAEEPGMEEAALVDHVDPTKSPTTPFADPLPESPQSDSFPLHPSNGPYPSPIPIHQSASSHSKSPSMSMSGPFPSSPGPTGMARYSTMRLDSSPMYDIRTSDYFTIAPAPSTAQRGRRGSSGVLGGEGAGHRRASPSKASGKVFFEESVKEESEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM71</accession>
    <name>A0A1E3JM71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial division protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033223.1">
        <property type="nucleotide sequence ID" value="XM_019174844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM71"/>
    <dbReference type="GeneID" id="30191915"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="740" mass="81303" checksum="C6988477E3B51420" modified="2017-01-18" version="1">MPSTAPQHDLDQSSYLPSSLNGTFSIAKEVIMGPFGSEHRRSESTRILSDLAPSLMQSRFLNPSSSTQRPLSNRPPSKPYPLLRLPTNIPFPNQRQTSSSLAIIENVDNLASLSLDDPALLHPGQGPPSLIRGFKATIPSSEMAKQRRRTVRGGIVDEDLGGELGLKRLGNRARGLLTEHGEADGEGELGVGRKAAKKRRKKRESRRLTEGRHDGKLRLEDLAKQADEISQDKDNLHVRQSLIQSEITEIGNKISALEEIRTRLERSLLHLQEEDLELNDELEGVQELMASPAYKAAAGTKAVPSSSTVSGPSKSSRRRKGPAFLPSEHDDLPSGVAFMTLAGHTAPITALDFDEPYGMLVTSGQDDVVKVWDLCDGEEIGQLRGHKAGSVKAVQVEDTLCLTGGADGNVRLWDLRMVEDYEERLQSQLKQLAQQDPLDRIAEQREQEGEDELHSGGWQEPGDWSPCVRTLEGHSKSVTSLYYEDGCLVTGSSDKTIRQWDVATGQCLLTMDILWAISNPPPPPPSSNIPTRPSRLSHRSSTSFNSTTYEDILPSPGASLLGMPGSSLLTAATSQNFAVPTPPYSDGTWEMYQDFVGGVQFWGYALASGSGDGGVRMWDMRTGQAHRTLVGHTAPVTCLQFDESYIVTGGLDRTVRIWDLRMGALSEMHKYEYPVTALQFDSRKIVACTGENGVEVYNRTTEEHRRLVVGGHTKPVEKMRFIDKYLVSGGRDGCAKVWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM86</accession>
    <name>A0A1E3JM86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033227.1">
        <property type="nucleotide sequence ID" value="XM_019174848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM86"/>
    <dbReference type="GeneID" id="30191919"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="288"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="694" mass="74747" checksum="1D4CCC6CCB823813" modified="2017-01-18" version="1">MPHNQLLFHRSLPKPRPPIHNGASLAHHHLKVTRQARAPIINIPPINLILITPDRHLLLPALGRQLAPYVTPNRRFFAPPPAQEQWLGPDGRRLTSQDPRPAFPPLQRPPPEHILAASSSRSTLSIPPPVQPTSYSHPYPAPAPSSAEESAQRPVLPGGHALTPMHFSMLSTHDHNPLHPSSSTVVRAKGHMEVPGKESFPLITGWQEPSSSRNKLPMRSRSRSSSSADSGSTSRGGSQRSFRDEEAQRTSRTSSTSSQVEEYRQTSGNTSQEGSVRAASVGVEHRRGKKKRTRALMTHAQQAGLMNLWKQASPTKFPTSGDREVLGQQIGLTARQVQVWFQNQRQKGRKTLLVNGGVPDGEDPADYEDLQKSPRSRRLSVEKDERIFAWAGNSAGGSVWPVADGHATEAATPSYGAGYSYLPPATGEHQFRHVPPNTKPFPVPPHTHPSAPLPPTSALSWSPSSQYPSVLEPPRSSSSLPNGDMAYAPAPLPSRSGFVDPNSASSSRGGYHSYEQYSRGYNVHPPVQGGHSPAYIHEASRQRSISEDHHPSPSTLPPPPSSFSLAPFGSGLGPPPPPILSAPITTPSLSQSNRQRADTRSSVQSVPSSSSATSTPASTSHLPPSLARIAIAGPVAGGDDLPSLLPGLVGGRKDEEVGSPRKRNASWTLPERRVKGRAQGEEEGSSSGVRKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMD4</accession>
    <name>A0A1E3JMD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033272.1">
        <property type="nucleotide sequence ID" value="XM_019174893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMD4"/>
    <dbReference type="GeneID" id="30191964"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="285" mass="30758" checksum="77463A88F34401BD" modified="2017-01-18" version="1">MSTQTSTQTATATSPILRLRGGPPAARSKPYRPPVFATKEEERKHLKERLAASFRIFSKLGYDEGVAGHITVRDPINPESFWVNPYGVAFDLLTVSDLLLIDHNGNILEGTGKPGDGQIYNAAGFAIHGAVHKLRPDIHAAAHSHTTYGRAFSVLGRNLDIVSQDAAAFADTVRLYDSFGGIVLDDEEGRNICAALGPNGKGVILQNHGILSAAQTVDAAVAFFVRLEQLCESQLKSDSIGAPKAVEQEDIAAVFAAHGGEEEAFFQAQEMFEWIEHETGGDYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMK3</accession>
    <name>A0A1E3JMK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 9B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033353.1">
        <property type="nucleotide sequence ID" value="XM_019174974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMK3"/>
    <dbReference type="GeneID" id="30192045"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO02101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="201" mass="22787" checksum="28195D27DCFEA18C" modified="2017-01-18" version="1">MAQTVTNIPRDGRLISLILASKGIEDADERVIHQLLDFSARYTADVLSSSQTLSDHAARTGASSNRIEKDDVELAIKMRKLYEFFEAPPRDYLATLAHELNSHPLPILPETFDLIRLPPPHQRLAEVNFDIVPDVEVAYMEEEDDESDEEREWDEQNGEEAKAEEDDGDEEEMEEVGVEGPSLMEPTAPTRQVDVDEDYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPQ6</accession>
    <name>A0A1E3JPQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033144.1">
        <property type="nucleotide sequence ID" value="XM_019174765.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191834"/>
    <dbReference type="OrthoDB" id="2565355at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1306" mass="142111" checksum="96BFC0008EE6E773" modified="2017-01-18" version="1">MEAFPIYEDIPPAYPQQAPPDYIDHASPPLPNYDYPPQVHPDYGFVEDYSRPPEPIYDLPEYVSSEEDPFDDIEIHDEWIDPSDYRQEEDYYDDEIFEESWIPYSSPILPNDSLPAAGSSSQNGNQQVVIAPPSFYPPPSDLRQHYCDLHPGDCLRDKLPIETNATERANATLDEDLSNGTNFKHVDLPGAGLALALLLIIIIALNASWSSDEKDGKKSKSINKTSAGGATPDSSAENGSDEAAKDKKEKEEKTAAAKQKREREKKEKEARRAAEAAANGSDEPAGSTTGADGQSKKEREAAKAAREKKDREKKEREEARAAAKAEKEAKKTAEEAANGGVPASTAGSDGKSKKEKEAAAKAAAQAAKAEKDAKEKREKEKKEREEARAAAKAEKDAKKAAEAAANGGGQPPASNSGSEAKSKQEQDAAAKSAKAEKERKEREKAEKEAKDKRDKEKKERDAGRAAAKAEKEAKAAAEAAAKGGADPGGRSTKETDAAAKAAKAEKEAKEKKEKEKKEREDARAAQKAERDARKAAEAAANGGSQPPASNAGSDSKTKKERDAAIKAEKAEKEKHAIEKAEKEGKEKREKEKKEKEEARAAAKAAQDAKNAKANTGSGGNPANPPAGGSAPSNGSGETPEQRKARKAREAASKQAGGGTDSTQGAAPSGAPENETPEQKAKREKKEKRERERQERANETPEQREARKQQEKANETPEQREERKKREAERRANETPEERNARKKREAEKANETPEQRAARKKREAEAKAKADAATTTNGGGGGGSTTGAPAENETPEGKAGRERREKREKEKQERANETPEQRAARKKREAEAKAKADGATTTNGGGGGGSTTGAPAENETPEEKARRERREKREKEKQERANETPEQRAERKKQERANETPEQREARKKREAEKANETPEEREERKKREAERANETPEQRAERKKRERANETPEQRKERKRREAASTGDGGTGDSSSGKHSKKHGGERSKSWFSPPLLLGLLLLIPLIAMFGKPSMPMLSTPTLRRPSVLGSGGLASMLKPPVMASTRARAAFASAKARRSRAAETRWVVNDTPPEPKTQININNNVNSPGGSGGGDAPPIEVVVEETSSSSAAEAPPVIVEETVWEPIHFRFTGPANPDRLYKMFITTVIVALPLLYDWVMDYPKKRYSQPDYLPPSTQAVLAMTVFLLCAYLADWSFAWVGWIGWTSTAIVPIAEVSISGAQSGLTPLIVILLETIESLIWALEDVIFGDGRTLLGMGLAALGVVMLGQREPSLDVPKTEYASGAVQGVYFLGALLIAMFVWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR06</accession>
    <name>A0A1E3JR06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033360.1">
        <property type="nucleotide sequence ID" value="XM_019174308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR06"/>
    <dbReference type="GeneID" id="30191366"/>
    <dbReference type="OrthoDB" id="10570284at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="17705" checksum="85339440D82AD238" modified="2017-01-18" version="1">MDDPSLDGPASLVRALAAWAEEDEQLQDTLMRSSPIQPVVEEDEDEDDEDEVTPSPADFREFQGDAGLGRRSKKRGQSGVAPTQNSQLKVEGGMSQPGVVKKRGRPKTSKKRKQPDGTLAPLGEDELLPAARSKKCKYFGRAVGEEPEVPRDDTDWRDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRK8</accession>
    <name>A0A1E3JRK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033514.1">
        <property type="nucleotide sequence ID" value="XM_019174462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRK8"/>
    <dbReference type="GeneID" id="30191523"/>
    <dbReference type="OrthoDB" id="2587207at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002146">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO03463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="912" mass="102259" checksum="49656159986ED293" modified="2017-01-18" version="1">MSPQESPSALLRNLKIFWGYESFRHPQLEICSDALRGCDLIVVAPTGLGKSLCFQLPAITIDHGVTIVVSPLKALMADQVEDLTQRGIKAVQLSEYTTWEQHNEVRKQMKMGHPEIRLLYVTPEMLLSDKHKSTFDIAYRQRQIARLVVDEAHVITEWGKSFRSKYRELGQFRQKYPGIPITALTASATLEVRKDIIQTLRIGKGHGQWVLPFNRRNLFYEVRYQGRGYYDDEDREPQKSTTDDMAEFLLKYRPQAMKRNEAKGINRPCVTGIVYCRTTAACEEVADNLRQRGFTARPYYKNLSQNVKDQALAGWKDGSIECIVATIAFGMGIDQANVRYVIHYQMPKTFEGYYQETGRAGRDGHISHCLMYYSREDAKYLRGLVEQEDAKNKRNAKFKDGNIDTSKTPSQGLFSFKSLQNHVEKAGQCRHIGICSYFGEKIDHTNAEVKAAYCENMCDVCKNSAAVRKASMRLTEGVPVASPQRIDEVAVVTQSVDKPFNGYSSAIEDDRTVPENDLRDLHGTHPSIFDFNDEDDDELEALGPSAPSRPHALQFRTQAVLNSGRSAPLSGSDSTEKPLVPGSSNPLASSRSTNSSVHHNQSSHTPVLERDLSGEERHHQPIRIREIIHIASGGSPTPPPSASLPKRRKVGLSRQASGLSNSLTSSVELENLEKGREVEMQKIRSRKEREREVALSRIQQRPEMMSPHVRYLEDSEEGTDSRLKLTRDQRIKAEKMLGSVKPVRDAVGPYACYNAAAGPSVPRRRVSAPDKAFKPPILRSPNKVRSELLTKSARDKSVTNIGSALQDSLGHGELAWKLLIFCGKNERGTKRANMLIDIARLIERDLADACREDPGAYNNQVTEFRKAVKALRSEEVVEAIIDGEIDAFEDGGPGVGYLKALIRLVKGYTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS27</accession>
    <name>A0A1E3JS27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033686.1">
        <property type="nucleotide sequence ID" value="XM_019174634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS27"/>
    <dbReference type="GeneID" id="30191699"/>
    <dbReference type="OrthoDB" id="10353442at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38571" checksum="CE3104B0D91F4CA3" modified="2017-01-18" version="1">MFSITPSNFAALHPVHHLILDELIASAPHLALLLCRSVYKRVIPILYAHVHSTPALFKGLQRKTEYERTEYALCNTKSLSVDGSTSLHAISALSSGPDPFSIPEKPQNTRPLYPRPYYIMLPYLERLELSFSALQPPVVRTGPRGQGAATRIADQMPNDLREIVFHLDEGTVGAWKELNGHLMSIGPEEAVVFVKGEARKGQLVKTPDGGQKRMTFGRIGEKLPTLWTNGQLLRVFVGTQKPWDSLNGEEREDYAVSMSLALVEYAQGLFGAHIEGEEWFEAEQEESPLVAEVEFHLPSLKQVLAQMDGEGKTDVDALVRQGRLVLKEYDFKEVEALGELKWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUM0</accession>
    <name>A0A1E3JUM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033673.1">
        <property type="nucleotide sequence ID" value="XM_019174621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUM0"/>
    <dbReference type="GeneID" id="30191685"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046898">
        <property type="term" value="P:response to cycloheximide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-0196">Cycloheximide resistance</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00084115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO03622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="110" mass="12376" checksum="0E04B66006172F97" modified="2017-01-18" version="1">MQEGRKEKADGGIVDCKGKACKKHTPHKVTQYKKGKDSLSAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTSCKTKHQLSLKRCKHFELGGDKKQRGAAISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWV7</accession>
    <name>A0A1E3JWV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034004.1">
        <property type="nucleotide sequence ID" value="XM_019174197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWV7"/>
    <dbReference type="GeneID" id="30191255"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="212" mass="21309" checksum="1E72E3ED2FABFE7A" modified="2017-01-18" version="1">MSGRGGFSRGGGGGGFSRGGGGGRGGGRGGGRGGFQQRDFGPPDTVLEIGSFQHDVESEMLCSLVTPTKIPYFNAPIYLQNKTQIGKVDEILGPINEVYFTVKMDAGMLASSFKKEDKVYISGEKLLPIERFLPKPKVAGGKVAKRGGAAGRGAPRGRGGPPGRGGRGGFSSRGGGGGFSGGRGGGRGGGFSGGRGGGAPRGRGGFSRGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX15</accession>
    <name>A0A1E3JX15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UFSP1/2/DUB catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033998.1">
        <property type="nucleotide sequence ID" value="XM_019174191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX15"/>
    <dbReference type="GeneID" id="30191249"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="164"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="566" mass="62549" checksum="94406435E020967B" modified="2017-01-18" version="1">MSSCPVCDQTVNPDQAALEHHVNSHFDNPSGESSTSAPRPDACPICDFPLSFLTSIESESHINTCLGDAGALPPQDEDDIDFDYSAGLVAQQKRDEEIVDPEWDGPAKPGKWMDWAGRNADKGDRWWNPNVPSDPSSIPPNYSPNLIPLLASTLRTAVHQKTTRRAVLARPSTAHIKGVWKFDLGWGCGYRNCLMALTSLLSVPGYAAVFDSAKNGADPGVRRIQGWIEEAWAEGYDLEGQQQLGGRVLGRRKWIGPSDMYAMLSYKGIPCRIYDFPKALNLKTDREAHTRLQQWVKSYFVRTQARQAGRNAFDTLMRSGENGQGRGELVRISDKFPLILQHSGHSRTIVGYEENARGDINLLLFDPGKTVPKAIRSHALSNLPEPTSFPIPPRPPPNPTAPANPTTSAERIRHRSSSSSHSKFERTHESRDFSPPYTDGFAGIDYSTAREGSHDGSQVEGSAPLRGGSTTEPALEDDEERTPSGWVRKKRPFPHLSKSHKPPKSSKPGSDPTAPGQSVKTLNHFRVNLGTLSRHAQYQVLMFTGEEVLGEVERGQRKKIRSVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYR8</accession>
    <name>A0A1E3JYR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034144.1">
        <property type="nucleotide sequence ID" value="XM_019173439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYR8"/>
    <dbReference type="GeneID" id="30190486"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="59"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="44346" checksum="175AF0970B4FED16" modified="2017-01-18" version="1">MSTTPAPGELPSRFGSFGGAYVPDVLVNCLSELEDAFVKAKDDPDFWKEFQSLYGYMNRPSELYLAERLTEELGGANIWLKREDLNHTGSHKINNAVGQILLASRLGKTRIIAETGAGQHGVATATVCAKFGLKCDIYMGAEDVRRQELNVFRIKMLGANVIPVTSGTQTLKDAVDELMNDWVESKDTTHCLIGSAVGPHPFPTIVREFQRVIGREIKSQFHEKTGKLPDAVVACVGGGSNAIGAFNDFLEDESVKLVGVEGGGHGVNTDRHAATLTTGIPGVLHGAASYIIESSPGQLFHTHSISAGLNYNSVGPQHAYLKDTGRVEYVVADDVQCLKAFKMCTQLEGIIPALESSHALWGGFELAKTLPKDRNVVINLSGNGSKDVAEVLLTLKNKEFADKLDWHVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ26</accession>
    <name>A0A1E3JZ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034151.1">
        <property type="nucleotide sequence ID" value="XM_019173446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ26"/>
    <dbReference type="GeneID" id="30190493"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57229" checksum="FC2851AAB9F83ACC" modified="2017-01-18" version="1">MSDATERQTLLPSSDTRHPLSQPPLTRSGSSATLIASNYGAVDRDTDSQPPKPKPEQELHHKQFHEIWALFMGLAFAVFCSALGATIVANLTIEIGSYFHAGSLSSWLGTAFLLGLTAMTPLYGRLAQVMGRKGCMLLALTFFLSKSLSTLVFMLFARGVAGAGSGGILTVTAIIISDLVSLADRGLYQGGINLLFGGGSASGAILGGYIYDKFGWRAAFWVQVPPVLFSFVMVIWKVDVGREEGEDAGGKTAWEKVKGIDWLGSFVLMMGISSFSIFSSLFTSSQYPFLHPLPLSLLITSIVACPVFYVVEKRAHQPILPLTLLTRAQPSIVLAGFVSTTATNFSRLYMQPVYLHVVRGLNGSETGLLLIPSSIAGSFSSLYAGWHMKHWKEYKWFQVCTSLIPWLQALSIMIGWGPETSATRLWSEMALGSLGGGATITTLLIVGVAISSAIQQSILISSLSSRFPSNPDLVRKLIQEPAEIMPLLGVEDAWEARLAYLDSIRGVFGFVVIGGIALTGVCIMIRGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZL3</accession>
    <name>A0A1E3JZL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034323.1">
        <property type="nucleotide sequence ID" value="XM_019173618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZL3"/>
    <dbReference type="GeneID" id="30190668"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="189"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="436" mass="48496" checksum="AA015B1619A82EB0" modified="2017-01-18" version="1">MSNASQISSENEGVPFSILDTDLYKLTMQNAVLHHFHDAVVTIKFTNRSPQMLFSRQSFQWAQERVNHLTDLRLTEKERAYLSKSCSYFSSSYLDYLQGVRLDPINQVKLSFMPKSTNGEGEEMGEIGCEIEGPWRDTILYEVPIMAILSESYFKFVDTDWSYDGQLELAKAKALQLLNPPAPTTPLVFSEFGTRRRRSFQAQDIAIKGLLSGLEEYRSQGGKGGAVSGTSNVYLALKYGIRPVGTIAHEWVMAVAAVHGYKGANGRAMDMWEEVYPPNTPLAAPLTMLTDTFTASIFFDEFISSPERALRWAVLRQDSGDAFEFLRGAKKAWRTVEDEAGGKQVIFSDGLDVEKAVKLQQGCDEIGIAASFGIGTFLTNDFYRVSDPSQKSKALNIVIKLNKINGKGCVKLSDDKGKHTGDVDDVRRAQEELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZP6</accession>
    <name>A0A1E3JZP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034468.1">
        <property type="nucleotide sequence ID" value="XM_019173763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZP6"/>
    <dbReference type="GeneID" id="30190813"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="3">
        <location>
            <begin position="80"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="468" mass="51021" checksum="B77E9A66E8F6A8AC" modified="2017-01-18" version="1">MSYADYITGISARFWEKVRFPNKFTRDVVWGIVLGITVSLSSTSAALIVQDWRRKRAMRRIPPRPIELRSDEIVPGTIGLIGNTPLMRINSLSDALGVEIMGKAEFLNPGGSVKDRVALQIIEDAEASGLLHPHTGSVLFEGTVGSTGISLATVGKAKGYECCIIMPDDVAIEKVQVLEKLGAIVERVRPASIVDEKQFVNLARKRALEFGQTELTNTPTHGNAVAVSTLAAPSEVEHDNFLPSSLEHKPRGFFADQFENESNYLAHYKGTGPEILRQSSGNLDAFVSGAGTGGTIAGTGCFLKKALPNLTIALSDPEGSGLFNKVRYNVMFDMKEREGTKRRHQVDTVVEGIGDTFLHASLLTLQQITHNFSLGLPVIDDAFRISDVEAVAMSRYLVQHDGLFLGSSSACNLVACVRLAKTLKKGARIATILCDSGARHQSKFWSDDYLKKHNIPIDTTIIDTLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K112</accession>
    <name>A0A1E3K112_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034277.1">
        <property type="nucleotide sequence ID" value="XM_019173572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K112"/>
    <dbReference type="GeneID" id="30190622"/>
    <dbReference type="OrthoDB" id="2576436at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15298" checksum="18D4F7CFD2D2C3E2" modified="2017-01-18" version="1">MTSKEFGRTILVKASHNEVVKAQALLSYAESGMGAVDFAKAWEPPNSLITDRQEWLIDQAARCRLDATILMALAMAAHPPDSLQDLTNANMYTSSNVTATTSEGCQPYSPTQGEGNPSYPTRYWRHGDTHPPLTRWQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1Y4</accession>
    <name>A0A1E3K1Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034617.1">
        <property type="nucleotide sequence ID" value="XM_019172891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1Y4"/>
    <dbReference type="GeneID" id="30189932"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39821" checksum="3D8F508713F00401" modified="2017-01-18" version="1">MTTVQKIKDIEEEMARTQRNKNTEYHLGQLKAKLAKLRRELIAPSGGGGGGPGIGFDVARSGQATVTVIGFPSVGKSTFMSKLTGTHSEAASYEFTTLTTVPGQMTYNGARIQILDLPGIIEGAKDGKGRGRQVIAVARTCNLIFIVLDVLKPLNDLAILTHELEGFGIRLNKKPPAISVKKKESGGIAITNTVPLTKIDAQEIRAVLQEYRMSNCAVSIHQPDATIEDFIDVVEGNRFYIPAIFVLNKIDAISIEELDLLYKIPNSVPISSKLWLNVDELLEVMWDKLNLVRIYTKPRGQQPDYSSPVVLQRGKCTVEDFCNAIHKEILKQFKNAMVWGTSAKHVRGQKVGLDHVLDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K208</accession>
    <name>A0A1E3K208_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034647.1">
        <property type="nucleotide sequence ID" value="XM_019172921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K208"/>
    <dbReference type="GeneID" id="30189962"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="185" mass="19713" checksum="4C9FDD2D1D385F60" modified="2017-01-18" version="1">MPIPMPASMPLLPPIYLPGQEPFPAGTTDWEKEEMQTALKYQRWMGMAAESCPFKVGIAGTGGLVLGGFFSLMSATFAYEDPLSRASEKHASTRAQTWFVMKDMGRSMWSSGKGFAKVGMVYSGVECCIEGYRAKNDIYNGVSAGFLTGAILARNAGPSAMLGGGAAFAVFSGAIDLWLRSAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2D0</accession>
    <name>A0A1E3K2D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034682.1">
        <property type="nucleotide sequence ID" value="XM_019172956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2D0"/>
    <dbReference type="GeneID" id="30189997"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="551" mass="60717" checksum="5B99492A942A9D3E" modified="2017-01-18" version="1">MVATITPSATSALLEDPSLVTESLSQLTPLEKFVLRLLTGEGDIAQAIRRYRASDEGAKAGKNDVSRFSFAMVREGQIAIEDGRNSWILVLWVKCWGLPSYISQESDLSLGEVNLSQRRLFDISRASFLLSLGSEAVTNDHFHKFITFLSYDLNGILYRHSLLIQRLWLESFETEILPASHTPVDGFTSALPELSEHIIKHHVPPIVPYKPITSTPSLPQLNEILPPTKPRLTKLVIDKTFASTSPVPSTPTMNVARTPVTEAPTISLSSPALTSHYVTPMATPHYVPRGVLASNPWRSIFSWLKCMLRGFAFLCQSPEPTRILAETIPELEREMSQISYWLEGGAGPQVMVMALYYGTRVEKAPAGVSNLKVPQLSQHTTHANRSIQSVLELDMSPSDLVSPTTDTALAAMTSVFDILVTSSIGSDSAQLAGDMFAYQETQSDSPLGRLKHASSGKKEPQDAFGTPPPTQSTSSNYQSSIHIPEPFHQAPTTPTPIRNRPSPRHVASNKQLHSHSKAASPRKKTSQMFKETMDLVRGKVPQMKKKSSKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2I5</accession>
    <name>A0A1E3K2I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034680.1">
        <property type="nucleotide sequence ID" value="XM_019172954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189995"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1934"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3048"/>
            <end position="3153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1361"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1693"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1699"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1710"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1729"/>
            <end position="1746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="3185" mass="354493" checksum="B1CCB01A9BE41A09" modified="2017-01-18" version="1">MQALKNAALGLLNVYVSPYVENLNAQDLSLSLFSGNLQFHGLHLKKSLLERFGLPVEIVAGDIGTLSVSIPWTALKTQPVKIVIDDVYALARARPPGKVDPEEDERIEQATKQEKLKSAEAVDSAANQVGQGAHDDSKQTYVGAIVSKVVDNVQIHVKNIHVRYEDGTSTPEHPFAAGITLNEFKAVSTDANWVEAFIHDSLNGVHKLVQLGALAIYFDTDTGSLDKGAEDRSGTINALRSMLTGSPNHQYILKPVTGEARAIINKHMSNETPKFDAQVIFDEIGVVIDRDQYRDVLSVVDVFHFYRRTHQYHKFLPPAQEAKETPAQRRWKFALDAIRSEVHDRNKRWSWAYLAERRDTRKKYVELYVQKLALPEGKQLPADEEAAVAEIETKASYEDIRFFRSVARARAKKDAVTRRKMELERQKNQPQVQTWGQWMWGSSAQSTNSENGISEEEKKELDDIIDYDAAAAEETAIESTPRDFMKARVSAKLNKGSLALRTDPHGKNNDIIALVFDSFSADAVQLTDSMTGKMALGGFRVYDGTTPGSLYPQIVRVKDIEKKASQISLAQEGVEGALDGIGDKSQDSSDPFFVVEVEQNPLDGRADNAVTVKMRHLEIIYHRGYVEAVHQFFRPPESQLESIGALLDAAGQTLDGLRKETRAGLEYALEQHKTIDLRVDMNAPIIVIPMDVTVKKSETLVLDAGHISVNSSLADKQQLQDVQSKRGKQYSEDDYKQLEDLMYDKLNLRLESTQLLMGDDADACMQALEDTDNSSAYELHVVERIGMSFTVQNAIVNAPNLTRFKIAGELPTLHVNFSDRKYKTLMKFIDVSIPKFGDEDEEQKDEPVAAKGRRHFGRRQPVEEFNFDDDRSIVSAKTIEERDDSSSIGDKGDHFYEANDDQTEKSALRQVTFEFSFSVGKLQASLFKSISPTEERPLADAVLEGFGLTFALRKWDMSVDLFLRSVTLAMIEHGSARKPLLSSATHGEESPSDLKLVQVKYQKVQKESPEFMTKHEGVDTSIETELSTFRFTIAPEPILSLYDFIMTTFVPKDQDNAEETAVASTQDHNIEEEKSTDKMRIRVKLTSAEVLLENNAKQFAMLTLPSADVAILLRGGTLRVGARLGDLSLDDLSDDAVADPTFKKLLSIEGGELADFSYETFDPTDEETFPGYNSSVNLRAGSLKFTFMERPVHDLYAFAIKFARMKAVYDAAQQAAVQRASEVTRMHYDIVVKTPIIVLPRDGLTSKDRLVLRLGEIVAKNQYLDDPDDTSTIDASLRGINVASEIALNDKTVTLQMVDDVAITAAIKQAGGSSHRVDPHHADTEITTDMSDVKLSLTQRQYILLMSVLQSLPRALSFDEDDGDFSPDESTAITPNTSVPPTPIGEEPPQITDVSLEPELVVARVDDNTGDVKQWTSLDFVFSVNSIALEIYNVDAVSEEDLKQNSIARFALVGSHVGFKKLSDGAMEAELSLKTLAFSSTRSGNSVFRDIIPPASHNGNQVMLQYTMAGGADQSALAIVTIDSPHFILAVDPLAALLEFAVSPFNKSQSEEAELQAVDDEDLEEGPKQGGALSFRVEIVNATVIVIADDTNPKTQAIQLNIRELLVSQQRILAVKVDQLGMSFGRMDRPTERVKFLDDLSVALSLDTRRKGSQQMTNFDIDIPDPVIFRASYTNVMLITDIVNKATAVATKALSPAEAPKDTSERERSNSLAVTSSLDASTVAAVASKHSRRRSSAGRRTSISRRRQSLERAQVIVSKEQLKARVNGFQFVVVGDLQEMPMVHLSTNEFNLSINDWSGDLKLATSITTSIRYFNLANSYFEPLMDPWKFDLTVNRISAGAGYNPLNVKLSARERLEINLTSAFIELAITSMTVWSKEGERALAGKGSDAPFRIRNATGLTILLWPEGVDPNKPVTGVKRLDDGADVPWRFEDRKQTRENISSVRHNALGIQLQDTPWESLRGISVDREGDHTYALRPRLDKVSHQITCEIKLVNNVKVITFRSTLNVENQTSLPVEMIVIDSHGKAASEALKINPGESCPLPLEAAFEKRFRLRPLRGFGFDYSWSAPLHWKSLLAKPIRPISCKHQTAKEPAFYFQAQANYDVKDPAAKIYPRMNLVLRAPVELENLLPYNLKFKIHDRNTGLSSSNYLVEGGSSPIHTVELSHMFLLNVAPEDTGFKQSEYAIINTDDPELPVEDHFQLADQQGLTTHLKLHYITYPNSGGAFKVQIYSPFIFMNKTGLPFDLAAKTWTGGQRPIAGRDIFESKWPSYLKGGYTVLSFPNDDRRNRLHVRVNNSKWSQPISFEPVSADMQISLGNASGEKDNFVGLSYAEGTGKYKLTKVITIAPRFMVKNTYTRPIKVRQYGTRNEYPVGVNERIPIHQLSNNAPPQMIMSFDEPDTDWSAPFNISDIGRTHIAVQRQSRGSPKTYLMRVETHLEGSSIFLYISREKEDAWPLRVANDTNIPLAFQQTDRDPVTTDKERQRPVHILPPHSVQNYSWDWPTAPTKQIKLFANPGDLRKGDKGIELPSSIDLMAIGVQPPMRVPSNDPKKRSATVSVDVRADGGSQLLTISPYNEETSIYKPTRPGAGIRRSESSTSLSSSTVAFETIAVSEKATLNVVVELEGIGISVITRKPDELLYLSLRGLKLGYSDYPQYYDAFIDCKWIQIDNQLFGGIFPIILYPTVVPKDGKELDSHPTLQSSVTILKDQSHGVIFVKYATILLQSMTIEMDEDFLFALLDFVKFKGASWQEDTQDALIEHPKEIPEPDITSTKADVFFEALQLQPIALELSFMRTDRVNVDEKVSTRNPFYYALNALTMTLGNVNAAPLAFRALFLENVRLSIPSLQERVILHYQEQFISQIYRVLGSADFLGNPVGLFNNISSGFSDFFYEPYHGMVMHGNKDIGMGIARGATSFAKKTVFGITDSMTKFTGSIGKGLSAATLDAEFQNKRRMTRRRNKPKHALYGVAAGATAFADSLTSAFEGVASKPFEGAEKGGAGGFAKGVGKGFVGLFTKPAVGIMDFVSNSAEGIRNTTTVFDQAELDRVRLPRYIAQDGVLRPFSGREALGQSWLKDLDAGAFFHDSYIAHIDLPGDDAISLLSNNRILQVQLRKLRVIWQVPFEDLQSLSLEANGVNLVNRDGRGGPFLPISEKAAREWYFKQIGRWVNCNFRLGPSHADQTVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Q0</accession>
    <name>A0A1E3K2Q0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Grx4 family monothiol glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034887.1">
        <property type="nucleotide sequence ID" value="XM_019173161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Q0"/>
    <dbReference type="GeneID" id="30190202"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="244" mass="26954" checksum="A95653BD4154B270" modified="2017-01-18" version="1">MSNFTEVASPEHFQELLSKDLNRVSVLNFWAPWAEPCAAFNKAVEQEAKQFPSALFLNIEAENLADISESFDIEAVPSFLLLRGHTLLARHSGSDAALLHSLLTQHASPASASAPLSTSSAQPQAPEAAQRPRTEAEIVARCHELMNKHKVVLFMKGNPTAPKCGFSRQTVGLLREKGVEFAWFDILSDEDVRQGLKKVNDWPTFPQIIVNGELVGGLDIVKEMMESGEWDEVIEGEDDDEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K311</accession>
    <name>A0A1E3K311_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035007.1">
        <property type="nucleotide sequence ID" value="XM_019173281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K311"/>
    <dbReference type="GeneID" id="30190322"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8486" checksum="335A61305BA166E1" modified="2017-01-18" version="1">MSSNYGPSSYLKKSSKAETGGSVSEIGESVGKQLEALDQKVADKTDELLQELDKMSNRIDALKSSTHTLVDEPIDQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5B8</accession>
    <name>A0A1E3K5B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035197.1">
        <property type="nucleotide sequence ID" value="XM_019172255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5B8"/>
    <dbReference type="GeneID" id="30189280"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44465" checksum="75188768F01C1E70" modified="2017-01-18" version="1">MTLEVDSDLKDAFKLLYDAQDDDWASSDDEPESPAEDAQLEHSPETLYSARITRKRLMSTLDSLFSSGPETKKQRIYNPPSPAIPSFIPSTQAIPDLPSSSTYAPFSPLALLSRLHTFQPFSYSPAHPAALSPVKAALHGWVNEGREGLKCEECKVKWGLGGLGDIKEEGIRGEVVCRLKKGFESRHGSSCPWRINRSPDDLYDKLRHLTHPPITSSLSPLAYRLSSECPALTTIRTSSPIPDSQTKHLISLLSAHSGKEHDVEESAAVMALFGWYPYHPNEPSIRVVLENEVKETELVACRLCHRHIGLWHFKSPSPSSSSTPTPPPSSSIPSKSLDVLDDHLTWCPIRHQPWEASPWWEKTALLGGGDEGSKARMKEGDVKGLLRVSAKLEKKKWRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5J2</accession>
    <name>A0A1E3K5J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035267.1">
        <property type="nucleotide sequence ID" value="XM_019172325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5J2"/>
    <dbReference type="GeneID" id="30189355"/>
    <dbReference type="OrthoDB" id="546212at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="609" mass="68935" checksum="D5C288486277EB56" modified="2017-01-18" version="1">MSYHQVPRDDPSDLPTTYPPVQHIGPPYTLRPTKHRVTPSLVLKYTLYAVGSLVVFHYVFVGAFPSSRYTKNFREQWQNIGWTEDDKVYAEQSTAASDLLAQLDPDAGQPGTFFRDAYPLRTMLAFWELAQKEVEERGLNTCSDQLGKGLVEGYHRSQLDYCIPPGKMGLDLIDNNMTAWEVEAGEKVEATRIVCSPVHRDSFTKWWPYPAAPCVSTNMRTVIGEEKKYRAVGCRVTNDGQDLNNEMGREKFIGTSAESLDMDDERGDCKERIEHTMVLIPRQDQWNPFHVSEDLITTLVSLFISARTAPHLINTRMQLVFTDNFVMDRNHFTPLWDRIGAWAPRRLRLDPWNEGECLTNAIHSVSAGASLLSAMGVGSSYTCASTLTWAAAHYYRHLFGLLPPSLSASATEEKTDKRKPINLLWLSREKLDRYAQSHHDWSSWRDVRHINNEKEFISTLREGIKSMCEEGSESAAMFGKAGCVFEDSRDTPETWASTTLSPTDPVPIRFAAIDPSVHALETQIHYTGHTNILLSPHSGALGLSLFLPPGEGVIVELQVDNVMGNYHFQHMAGEMGHRYESVRIDRTVDSKRVWFYVKNWLEKLGAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Q2</accession>
    <name>A0A1E3K5Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase A-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035248.1">
        <property type="nucleotide sequence ID" value="XM_019172306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Q2"/>
    <dbReference type="GeneID" id="30189333"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="385"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="559"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="843" mass="89539" checksum="367AA0221E1989AC" modified="2017-01-18" version="1">MSAPYKLAFSLHGHAADVRHVATPNAGIPLLLSASRDGSALVWGPSTTCREWDVKLRVEGPEKRYLSCAALTRSHGAPYLLVGSQSGILASYPLPAPASAPPAQDELPEPVHTLIEHSQNLCCIDVSHDGLVATGSWDKSVIVWKDFKKALSIKAHEQAIWSVKFVGEDRLLTASADNRIILHSLDLASGRSTPLQTYTGHTQPVRGLALRPDGQGFWSCSNDGNINIYSFDKPAPINTLSGHTSFVYSITALPDGSGAISTGEDGTMRVWSDSELVQTIPHTSNSLWSCTTAPPPPSSPSSGPYIVSSSSDSTIRFFTNSPELVAPEEELAVWDAEVKGRQLDKSQVGDVKHSDLPGMEALGREGKKDGQVLMINNNGQVEAYQWSTPESTWQQIGQVVDAIGQSRKQLYQGKEYDYVFDVDVSEGMPPLKLPYNTAQNPWIAAQTFLQDNELPGSYLDQVVQFIEKNTAGQTLGGGEAQGYVDPFTGGSRYTGGGVPMAGGQANNADPFTGGSRYTGGGVPTHTPSYGGGDPFTSSGAYSSTPPPASTPAAKKQKQAVLPVKSWLAFKQINVAAVKGKVAQFNEQLKGTGAELTTDENKALTEVYAFLSLPSVALPNPEGGDGQEKFDPNTLTGIISRWPEDKRFPLVDLLRALSATSPATSALSPAIITQTLQASSGPLSKPQDTNLLLTLRALANKFNTSSGRGVLNQETVGQQVLTALGGISWQGVGKNSRVAAATVALNYSISAQFSLLPSSLAPLLLDLVIAIISTEKVEGGDTETVYRAAVAFGNLISADKVSGGLAVGKVEKGRAVVKKWTGKEPRLGELGREIEEKLSQGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K623</accession>
    <name>A0A1E3K623_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035322.1">
        <property type="nucleotide sequence ID" value="XM_019172380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K623"/>
    <dbReference type="GeneID" id="30189410"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="299" mass="32915" checksum="BA8B62BDC0CAA170" modified="2017-01-18" version="1">MPLCTRCACPVDTLYTVYNSQQNIRLTVCPRCNQFADPLIEHPSLLLFLDLVLLKPRVFLHLLFNRGSVPFLSAAPNPPEEEREAIRRGRLVDDLSLLLSLSITAEVLVRLLGFENLDTERVGATIGLVLLEGVAQHLATLGLALAALKVRSWDSVSLKQLRAQPLELQDGRQQYFLPILIPITLLYTALLPLLFQLFLYPWTNPVTTHQTPTSLLSTLPILGSWAPSPAITAFDKHLSLQWAQTDKIWAGTRLLGGMSAGFGLRVLLPTKPWETTGIVLAGWVAAGLVGAFGKELLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K640</accession>
    <name>A0A1E3K640_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035466.1">
        <property type="nucleotide sequence ID" value="XM_019172524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189555"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="426"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="843"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1326" mass="144165" checksum="61B282DA2D32F7E2" modified="2017-01-18" version="1">MTFGSVGKAATKKHHKQSPFPATPYLHAAAENSAAENRDRQRRPSDPDVDQHVVDIAADYITTQHAPPSSLPGIKGDLPSRGALSRNSSFASQSAPPSPSYAPSEVFSEDSTVSHHPYTSRGAIRTTRMKGRTATANTRAPGIMEEEEQDEVRGLRSESKLGLGGLGLNQSSLSVGSRHKADKMLGLDPNAKLASMYMVSGLGKSTAEWSLADTDATRGVQPLEDSLGLFWRPEMLGSSFSGDKQDRTGSTAPEDGTRARKDSKSSTFTNGGLSKDLRGRHVADAGPGGAQRLVSKAIKFAHPRDVEVVNSALAPPTTCHAFSFSIPRQDTLAAVARERLGSAVSGMRNASAADLDRPAPVTSKDMTSATELTYYGVTLTVYSHADKDRALQLKVIKTRSERLKLGTQSSLNSMNPVSPNYHPPGTRKASTTSDRKRGRRHLGNLLRNQSEGDVTLGSETETGVSDSDMEGPLSRRRWAGDRLSVVESVPEDVRAVFDEQNDVFWMPYAITIVSRFPIYDTLQDYLRLSWARFSKNARVHMTQVGRLLNTTPPRPGEAIFLPVGTSVDDEVVLEVSMPGGLIDFDKGLVKVDFQIWPLFQALDLDHILTCAEVALSNSGRIIFCSKHPAMLNIAVSSLKYLVELRGWNGITVPVIHARDATFVIEDPGPYIIGMSTECRYLLVPPAQVVIVDIDTNSLSCRSPPPNVITPRPRREKSKHKLLAALGPSYPTDRSIPMEFKVSYPKGSFRPFNKMTWAKGEKPAYLGERLRVPGWWKAESVVVVFDKILADKHKKPSLIQRLTRSGVNRAQAQLTVGEQLAKGMMRRRARKLLPSLSIHYVEARDDLEVKVAKINRRLLRLIQEGEHWKSQFETFEKYADRLTVEANELKTKIERERKEARRLSSIANEQTKANQDLEEKLHNTESARAQAMRQLSDMHSSIQELEREREEIMNSIEMQIAGALNQYLPPPSPSISSRPSTPGHDGASPDITSVTRSLGRKADRPFTADSQRSGMSGMTGVSVLGHAKGERGKIPIGREGSVVETVQTVEGRLPGSLEGSIADRVANIQIKIKLEMALNVVSSQRASSSMTNRTNEESEGEDEEAYADADDDAETSANTSTETAVEEDDGSSPDKTLIEPPEVVSTLGLSDLGGEATSGEETDIETERGSRNGASRPPSVVEAEAILKGDFPPVPIAPVGIVGLDRGKTKIRPRRETAKSTVSVEDKKLVVVKPTAAADDEKVVATNKAKATKVKSRARPTKTATATEGIVLAHVGVQSDADSDSGRSDMTAGRGKKGRKGLGVDTNGKRLSAMSTASTTITFGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K665</accession>
    <name>A0A1E3K665_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035362.1">
        <property type="nucleotide sequence ID" value="XM_019172420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189450"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000071">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1529"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1638"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1403"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1450"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1466"/>
            <end position="1475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1730" mass="192165" checksum="0B235ABA3E92EC4D" modified="2017-01-18" version="1">MGEEQPAWFTLQHQRNIIELDFAGTLTATAYLTVLPNNPSLQAIYLHASPRLQINNVTLSSPTTSEPLLPTPASFALSNPFQPLPVREPPIDIKSHPEIKRKTWTALGESDEGELAVSVSGGWVRLVESPSREGQDPHVAFAPIQVQIDYQLVVGGDVIEGIVFKRPGDGGNDSQIPHMFLSPTTYNSARVWTPCVDSLFERCMWELEFIVPRYLEGGEPADGEEGFPVMVVSSGELMEQITHPHDPNKVIFYYFQSTPTSVQHISFAAGPFEMHCIDDTAQKPLIGFCLPGELDLLRNTTAFLPAVMEYGVKRGTSYPFSDFKIVFVNGPRVECLTAATLAIASSDLLHPSTVIEQSIKVRQTLALPIIQQWVGIFIIQRAYSDTWVVNGIAHWMLAEFIQTLLGNNEYRFRLKKDIERCVYQDQGQQWPLCVPGQVDPPDSSTTAFIDLKAPLVLHILHRHMLAVGTAGGLPPVLTRTFVTALGDTLPENKLSTAFFLRLCRKISGHDLQAFQEQWIYGSGCPRLSIRTNFIKKKFTVEFMVSETAPAWETIHGLSEKQKKVAIWRRPTKFFEGPLTIRIHEADGAPFEHLIDIKTPNKTYPLPFNTKYKRTRRSGHIAARFNRTQDAAADDSAGNDNEEEAGLQAVDRGGVFVHPPWDDEEERRRWKVAEWGEGEANAMLGEGGGYEWIRVDPDCEWLAVFEFAEKPWCWISQLQGDKDVIAQLEAINNMRMYPSPVIASELAKTVLVKNYFYRVRMEAARALAMYNTSECDYVGYFYIMKIFQSFYCHPTTGTETEAPEIQCRPLPNNFSHIPDYFVKKSLIAAMSDLRDPASRTVWRHVRTTLLGLLRSNDNTSNQYSDSYYLASIITAISNSFTTSSVGIGLLSELDLEAEQILLKEADDVLDRAITVDRLVPSFHNVVTKAVLQSQIKSILAGQRTNDARELLSYTRREGNFEPIRMVAFDGLLLCKPPGRSVNVDRYLLDVISFDSSLNIRRHVARSLSEAVLASLAMGEITGTLSLPGIVDVTDETEQMREQRAEGQNNAIVKALRKDYGSKPEVKQLIQAHNGFTSPDPEVRFALLKVAEIIASSTAEPLPGSLISISTPTTSTPVAPLPPKIRISMPSAEIMPDSNGYGFPTVDNPVITPKSSKVVLNPTATTTAAPKSGKKKRDGPKSQSKGLSDNDLKAITIALTKLVSDKRSFFFRQPVDPVRDMAPDYATVIKHPMDLSTIRAKLDNGMYSSRQEFVEDVRLMIDNCMAYNVSPQSVVRKAGEQFERFFNSLWAKTENTLSAQRAPVAPAPMAPPPTMAEAPFKLKVKSAKSVHIDSNPVMPPPPLPPTKRVSISAPITPVQAGPSTADEKKEKKKRKEPVKAARNDLDELLGAEVDAITFSRVSPDDPVAQLLDEPKPPSKKIKLPRSAPKRLDSSSADPKPSSEGKPKKPKIKLGASAEGSSSPAPEFRAPPPPPPEVPMSIPSMSAPMEPVPVGLVVRPPPPQPPATLPPTKSNTMPFKAKRAKNLWNMLQKDPSAILFLRPVDPIMDGCPTYLDEIKEPMDFGTIGKKIEQKKYKTMGSFAREIELVFANCRQFNPPGEITALADAVEAVYWKEWPKAVSPKMNGDEKKSITSLMNQALKNPLSEWFRFAVDPVALGIPHYFDIIPREDARDLGLIKSKLDKGQYQTVKQVDEDVELMVENARVFNGEGPVVDAANALGKWWQTQRSKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K870</accession>
    <name>A0A1E3K870_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035572.1">
        <property type="nucleotide sequence ID" value="XM_019172630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K870"/>
    <dbReference type="GeneID" id="30189663"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="181"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="398" mass="44570" checksum="CEC3A3E2472973BE" modified="2017-01-18" version="1">MAVATQKIPKAPTAPSTSIKTYYQNKIESAELDITRKTQNLRRLEAQRNALNARVRLLREELQVLQEPGSYVGEVIKVMGKKKVLVKVQPEGKYVVDFSSDIPVSSLTPNLRVSLRADSYLLHSILPNKIDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGKGDSEVQRTMMELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNPEARITILKIHSRKMSLQRGINFRALAEKMGNCSGAEVRGMYALRERRQYVGQEDFEMAIAKVLKKNAESNMSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K967</accession>
    <name>A0A1E3K967_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035647.1">
        <property type="nucleotide sequence ID" value="XM_019172705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K967"/>
    <dbReference type="GeneID" id="30189738"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="104" mass="12080" checksum="E67AE65BB2594122" modified="2017-01-18" version="1">MTQSADTAGYNQRAIKNLTVDFNDYMVHSSWDHVGRPMSEDYAPKNDGRRPPVGHASMKNWRIAQEDPWDNEIYDNLHKRLSLFGQWYNEEVLGRDEETCSGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP13</accession>
    <name>A0A1E3HP13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anaphase-promoting complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028052.1">
        <property type="nucleotide sequence ID" value="XM_019179991.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30197229"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1608"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1737"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1969" mass="218097" checksum="863032770F4792FE" modified="2017-01-18" version="1">MLTAAPLGSPSSAAHKQHRRDTPGPSSDPLRHLLPHDQHQHDYGTHHHIRKSIRPVLRDDGEWTEEALAWYGRTVVWSRGAEVYQRYTYEHEGESVGYACFAWLRTGGGSSETSKKRKLASTTSSTPDTFGPFHRSQHSSWGGPRSSTHKNAPLRLERTLVVFLQTRAHVYYADGSDIIVHLPFTVDGAWGLPNGGILVQRELEKRELRKFGREKKKVGSVLRGMADQTSMSILDDLMDIEDESAPSLPRLYVLENPFDELKVVMQGQIEFGDTLHLSSTHPISATCSVLMVSEDPYPFVVVHDQHAGEFIIYRRTCVPIIPHQPAPPPNPRTMRPEELLRQAELTQIPPQPRASRPSLHRNASSFGATTGDRRLSSVADSLDRGQRRVPRLSRGPLPESASTDELHAVLEPDANLPPPTAPQHRRSRGMSMLPHSQVVPPGPEGQRRLSTGLPAQPLPIPPRMALQTAVEKDLRETTMMMGLERDEVGVRSEVVLSVIGRWKQPYPVDPQQLNAFISEDKGPNQVTVNIHVLPLTPRPSTSPQLFSFHITLPPLSNRVKIDVATPLKCLSAVPVLATRIPTFSRPAREGVYDVLFLTLEGRTQLMTSGRKILPFHVPVEDGTIISSLADASGPHFTAVYEDGSAKQYSAAMRIRHELTEQCFLALSGSLSAEEFYHYKIEFLSSLQQLKPWEKNDEERVWGVFVRVLEGILGVDHDQVEQHGFGGVTQAGLGSADPISRRLASLLETSTGPLSKPSSTHAPRYTLPPQRAVSLLLAIHLVGQDQRLALSKQRDLERVAGLIIRLAIHVGRKDWVDYWERLVPMRVHNVTFGTGLDYQLLDQFSHPPDIIVSLYQQLRLPVKEFIRPETLYLYRHGTGSDLSHTDELGPLDTCPRITLVARIYKELGPSTPASARPLQERAYQTVRTIAETITNPDWISDLPHGVSLPILEVLRACQVSPEKDWTAGMYKLVGRSDLVKKVEEGGLGEIVAKDDWPKEVSRDILNKSRPTVGEIMKAAETGALGNKKTDLALPHVRFRTDRRLQEVERIMQTTKLRIVTIQDPKGASAEDVTRYHQSFVNTLASRTLAVTVGQGMFEYGTRTTVITDVWEIPFIELSVKVTPGNTLLKAEIVSDSAEWPCFHNGVSAGLLISPDCKDIDSSWIVFNRPGVLNAEHGGFLLGLGLTGHLRSLMTYHAFPLMEPRHDFTSVGLLLGLACSYAGSNDLLVTKILSLHTHALLPLGSVELNASPIIQSSAMVGIGLVYVGSRNLRMAEVALYEIGRRDMPNVDGFGEYQESYSFSASMAYGLIMLGRGGSTASEVDRKMLAQLRKCIVGEAPVMDGSHAKTASPGVDINTTAPGATLALGLAYLKTMRRDIADLLEIPQTPYELEHVKPEWCLLRILARALIMWDDIAPTTAWVESLVPSFVLAAVKSNQRPSSIDLPIELAYLNIVSGAAMAIGLKFAGTAKELAHNTILTQYSILAKAVSGQSMTYEGRIRRTSARQGLNVVTIALAAVMSGTGELGLLRRLRVSHGQEGAGVTYGTHMAMHMALGLLFVGRGEYTLGNSNLAIAAMCIAFFPRFTSSPADNKAYPQAFRHLWALAVEARCLTARDVETHETVYLPVKLRFMEGGTIRQQSLISPTQLPSFDRLLTIEVDSPRYWPIKIDLSDPRDMEALVRTRSIYVQRKAGFIDYESDPKGNRSIFVRVGSMTGIDLHYDLISSGAPPSVGVEEVKEIVRVHSGDAGLVGLAEHFEGVDDEWGGGVGAFLRTIIIECLALDKPHLIPIYIQMYLSLRRDAAHITNPALYQSGGMHTVDQLTFAKRFYDEEYEVNFAQMKVSGERRIALVRQSFLNAARRTLLESPGEEDVAARYLLQGVEGWREDPQRLGRWLARNGVPPLPLLEALRLGVAKLAVGKPELEMKMRDSAEIYWGEVLKTYSEQSDGQGRRGEGWKLHSVQQTIDLWRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP39</accession>
    <name>A0A1E3HP39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028050.1">
        <property type="nucleotide sequence ID" value="XM_019179989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP39"/>
    <dbReference type="GeneID" id="30197227"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="526" mass="58719" checksum="DE05ADF0BF11F984" modified="2017-01-18" version="1">MNFYKSAALALDHLEKNQGSVKGSLAAAGVNAVGGEAKRILALIIETLKYRPVLLQLLTTVPILSLEKLTFPRKTPFRAPSSQSLVLVLLHDLLFSPRTRIEASDKWPPKPAVMRHQARLKAELVRIQIKEGKGRKEDLAKTAGDGEAVRYVRFNPNAGRTLEELSEHLTKKGYERLEEAVYPVPEGKYFADPHLPEVLFAFPGNSNWWVGDEWYEGGGAILQDKASCMPARVLMEEWVEGEGECLDATAAPGNKTSYVSALMSNKGKLHAFERSPNRFKTLEKMLAKAKCTNVKAQRADFTDSDPKSKEFKNVTRILLDPSCSGSGIVNRLDYLVDDDTEESDSKNERLEKLAGFQLQMILHAFKFPNVNRIVYSTCSIHAEEDERVVMSALQSGIAKERGWGLARRAGVIPSWERRGRPEETGGNEDLAESVIRCLPEDKTNGFFVSCFVRNGLRPEDGVTRDQRPSKRSRDEIEPVAEDAPAEGGDEAEDGDERGKKSKTEAQVERARRKKQLQKAKKRKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPA9</accession>
    <name>A0A1E3HPA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028072.1">
        <property type="nucleotide sequence ID" value="XM_019179950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPA9"/>
    <dbReference type="GeneID" id="30197188"/>
    <dbReference type="OrthoDB" id="10305899at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="406" mass="45169" checksum="0C894590A3FB1538" modified="2017-01-18" version="1">MVSTKSKEQGTEQEEEGLLSRNSADTQLKANDDGRAESQYTPKSSGSKIQQVTGKYNALAQVPPLTSNPRPASTSLSPSQPCSPLTTYNQMIDQWVDAQAAYTGTWRSRYPVMYAILTVYCIIPEVVSLACHNGWMWGIFIVWICLTLIPGTLYFVSKAAALKNVELVGKQMRLLLAANVEYHDLSILNFLDDDTIHPPPFSPIPPSILIFAHDWYSKESANFWAAYFFFCGYLMCLFLGSVDILDDLDESGGLGWAICGVHLILITLLWTYAAYDPYSHLRGKVDGQGAKRRWAWHKKHFHSWGIKAVQDVLKPDDISELKEAAQLPQTNNTPARYTIPRVVTVPAPANASTLSTNALLQELQRRANGDNLLEELQQRMSAGDAARAAYVALLGPRREVDPPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV44</accession>
    <name>A0A1E3HV44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Wiskott-Aldrich syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_07846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028194.1">
        <property type="nucleotide sequence ID" value="XM_019179827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV44"/>
    <dbReference type="GeneID" id="30197057"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000010">
        <property type="entry name" value="Related to Neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="6">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="458" mass="47516" checksum="B7E3F649B326DB1A" modified="2017-01-18" version="1">MAPPSILSPDDKAKVKKAVPTSSSSNKIVTATVARVYHAKPGANSWSYSGVEGAMVFCADKAKGGLWFRLVDLTASVIWEHELPNEIEYNQEKAFFHTWQGDDQSFAFVFPSETEAHSFYKKVANRSKYATKIKEKKEPAEKKEKSTPTKKKGGKAKIDKSMISGPSVGSFRHVAHMGFDSEKGFSSSGVDPSWQKLLEQLTQKGFSEKDIQNNQQFIQDFVEQQGGIEKATAPKKPPPPPAPTSRRKPAPPPPASRANRTSTITSPSSPAPSSPIPPAPPARTSAAPSAPPPPPPPPPARTAAPPAPPPPAPPAPPARSNVPPPPPLPPTRSSAPSAPPPPPPPPARPSAPPTSPPPPPAGAGGGHSALFASIQGKGVGNLRKVDPTEQKVSPLAGGSVVAGAAGGAVVGAGAAAAVASTQEDNGGDLASSLAAALSKRKADIGSDDEDEESDDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVG3</accession>
    <name>A0A1E3HVG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028216.1">
        <property type="nucleotide sequence ID" value="XM_019179794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVG3"/>
    <dbReference type="GeneID" id="30197022"/>
    <dbReference type="OrthoDB" id="2597010at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="684"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="895" mass="99589" checksum="EF6BEFC741FFCC94" modified="2017-01-18" version="1">MDDRTPFPLFLPSSGSQGSATAPLHRVSTIPPACIPTSMADALERVTFGPRHFYKKKKEEVTSDSTTRKRPAKAGYDPLPKRPRREHPSLPKNGALHSAKAGPSTSLPPEHPSLHRTLVASAQRTSSSGQRNPDSSDAKHFWEILNLEHVFTYQYNPEVVPRLVRGLIKVVNHLTTLSLDESLALNELVQFLFQLENRHSVFLPEPLRQFERGSNSFNFDTYEQRDKKGGSDVVRLVGYGGKEEGSTALAFSGECQAANIYAKHLSRLAANDPSTSSRLESRIYQYAPPVFSGVLDLAARPDPDSDAGKVKYQVTISTKLGIERKDDITLRDLFVLFYLLLDNDIKIKVDPSTGTSSVKGSEEVKKMLSTAIINILAQVAQEFHVNRCEYINLAIHDFSVTFQLKDKNLAHVSRIVFRDPATAERDILHKDELDIILSGIRSETDRDEAVKMLLKRTPWETDPQHSLFAVLVAGLVLPVGEDTKSMWINGESLSNVQQASATGPTSKVPPRTTGLPTTTTTTDTSQSGSTATGGPSAFKMVSYPAVATDLQSLQHTDTTHALVMDWLSKYRWEEDPTCRVQVSRGKTSLSEFSDKSASSGSLSIPSLTTDGSGASSSSPIGPSSHTTATFVGPVVSTTGDEKSFWREPEDLDEEDLDEEDLDELLRKTDHQTVLSLLSRPDLLVEVLQYLGSGRLWDAYRVKLSSRSTLSPPQIVVAKICNPYTFTPSDAYYKTPSAAADAIKIELDTLNRLRGVQGEIVPRLYGRWTGRYQLPNDEMARLECVMLEDCGMPFVQSDELELESYYDDVVETFPTYLSSDVRQQIIESYERLHKQGMLHGDVNARHILRHPVDNRPRIIDFEGAISISEAQATYPDYDAEAEMERVRWMLRADEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I1I6</accession>
    <name>A0A1E3I1I6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028310.1">
        <property type="nucleotide sequence ID" value="XM_019179693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I1I6"/>
    <dbReference type="GeneID" id="30196916"/>
    <dbReference type="OrthoDB" id="10296266at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="440" mass="48904" checksum="2D065C6B4C9DEF24" modified="2017-01-18" version="1">MSRPNTTVPIPLTDVTLDSICETNLAADLYYQPTLAPITQRPTNDQNNANLHEAYVQTCHDADCNAKSISSRVPFVSGERAVAFYGRDKYSKEAFEQSLRNGHWYCPSHSAGAPSNPVIAIESCGIEFESRDDDEPYAEEILGSGEDGPMHRWRCTAPIIVFEYGSVSRDEEGYRGCSRFHKALSLARGPDNRISLPSIETEENALVQYTAAPHPNNQMLLPPVTTLLRLTSSEEDSRSVAGDGAPSHLNDPRQSAWPDNDILLVDADDEAPSPFDQAWNNTAKYFDDPRHPASIWCEAEPIPTCTVCGSSVIGGGENASREERKQYWKSDIAKKDTLASHRLGTITHPACGPVWEQQTAGLPRIQAECADSCGVSFNIVSYHEDKWPNRHKTDATSLQTNYYALPWCRSGVMEDFLRDKKYEMYEKSTSAWRSTNSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I295</accession>
    <name>A0A1E3I295_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000040">
        <property type="protein sequence ID" value="ODN82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028302.1">
        <property type="nucleotide sequence ID" value="XM_019179685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I295"/>
    <dbReference type="GeneID" id="30196908"/>
    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="30592" checksum="D37AFE73F4FC6D50" modified="2017-01-18" version="1">MSAPAPPYAPARPTATRPSLTSLPVHLIHRILRLTLDQQATPTRFWSDAEEERVRRLWALFRALRGVSRVFWIVATSILRAHYLAPFLNLIHPGYSSDPFPFESSHLSDPSLSFDSSAGGSVYAERGRETAVFDRFIAVRVGEVLRRVESELSEGSGAEVDIFQRLQPAARIEDLISTLPPHFITPTSILPSPPPPNPKRTLPLPQALVSISLTPNWAQVWINAQVQGVGLARKGEGKKEMVLEVRRVGTLEGIVASVGEGLDHLRLGLVRWGGRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I338</accession>
    <name>A0A1E3I338_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028281.1">
        <property type="nucleotide sequence ID" value="XM_019179734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I338"/>
    <dbReference type="GeneID" id="30196957"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN82326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="46694" checksum="6A45B8E1ED4C3962" modified="2017-01-18" version="1">MSKKSDLLVRVRYQNPLPQPPFPPKLLDVPTTVARLARPSYLEQLAASTPLAMLVDSEMGMHINLNSYDGVWNGEDQSLNPIPDPDRVHNPIDLTLLAPFNPPPTATGEIKSAPSATDVSWMRNNSYITRRNNARRKETAAEAKEDEVVDASEAAQLLTIEKSFLDIATQDPKEVKHPDPKKRYLTVVDSYDILPDDEAWSNNYILLRFPERPSASTAVNPAAGASSPRLAKSILRPIVEDEQQMMDFYLPQEEDVANIDGAYNQAVDEEPLQRILQLSADDTDDPEIDRTFANTHYDRIRTYEVVSTVVPEKEVLVSFQEEESRHRREELDNQDDRWDKGRIGFRKPNETDAELRRKGRSRVADPGWANEQLRAIHGGENMAEGQGEAIDDEQDEPDDGALRAERAARDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAJ0</accession>
    <name>A0A1E3IAJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028520.1">
        <property type="nucleotide sequence ID" value="XM_019179482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAJ0"/>
    <dbReference type="GeneID" id="30196699"/>
    <dbReference type="OrthoDB" id="10460443at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11537" checksum="19634BA9759B8DB1" modified="2017-01-18" version="1">MSSHHTTPRETREFSAARAAREAAEEEDLCEYVQFHKGANARPDLPHLLYDVPAIGDDPPPYLHAVYSSELSVERIEGGERRGEERMDDSNTLFYVSTMNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBA9</accession>
    <name>A0A1E3IBA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028604.1">
        <property type="nucleotide sequence ID" value="XM_019179463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBA9"/>
    <dbReference type="GeneID" id="30196679"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000908">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="65179" checksum="DE2BABEB1BD0C527" modified="2017-01-18" version="1">MVRQKKSKQQPAPQPPRAEITHGWHKDQEERDLEESLFGRSNKRPRVAADDDQSGMSDLEDHDLFTVDAPMADDFQIDIDGHSSSDDDSDDDEHEFRAFSPSANDQDDELHFASDDEQDDAHRPTLDFPSGLIDLEEEYEKQAKKGKATLWEDPADQMVAVDVAGDKRLKKIDRGKRKAVVGEKVQGRVLQARLQEQFETLHPLPDWAKNRTPTGTPTLSSLLSSTKSFIAPSSSSTSRGPLPQGTLDLKRAKNANQTNPTTNKRESKSGQGGVVDFAWHPVKTVGVMAVAGGDRRVRFFNIDGHTNPTLLTLHLPSLPLSKSTFHPSGTSLLLTGSRPYYYTYDLASQRCLRSPRNLWGSSPSPSAPNDLSRHRFSPDGSLLAVAGLRGAVSVLEYGPSGAGALVAELRSGRGGSIFALDWSLSGKQLNVLGGRDGAEVEIWDVGQRGIVGKWRDEGMRGGNVMESSGDGQYTAVGSTTGIVNLYSTPSLLPPTPTTTTSSPSFTPLSPTPYKSLEHLTLPTTSLAWHPSSSILATSSSLRKDQLKVYHLPSGTAFNNWPTDGTPLGRVTSTGFSSGGEWLGVGNQRGDVLLYGLRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICE5</accession>
    <name>A0A1E3ICE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028658.1">
        <property type="nucleotide sequence ID" value="XM_019179410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICE5"/>
    <dbReference type="GeneID" id="30196619"/>
    <dbReference type="OrthoDB" id="2577343at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="42547" checksum="6754D279A0CD1F72" modified="2017-01-18" version="1">MLINQDSRLLGSYSWEIISGLWSDPQDHEFDMNEEREGRAPDVEFWKEIDKGWWFDGDFVVRTAHQQQHKLSAHRRSARHIKEGRDETSGAVMYRYKEHRSTRAAALIKQFAPVGKIRSLWFEEFIDEKESSATFLCATQMSHFLTGLVMTLHERRSWGTLPLEMERELILRYYELIRSEPGELGQMLRTISHWEEDHHKPRRWVPNATFAMFKPLDPSTVFYQECEHHFPMAIPSTFISVAKLALIRHEQGMDKVWWDAWWLVRPDMRRYFRINFGVRYDYLSVREEDIYLRMNYPDGRQVVESDTAYRNFPKFEPVDPWSCQVTQPNLNEAETLTRIRRLPETSMPKHMADSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ICN0</accession>
    <name>A0A1E3ICN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000032">
        <property type="protein sequence ID" value="ODN86334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028711.1">
        <property type="nucleotide sequence ID" value="XM_019179355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ICN0"/>
    <dbReference type="GeneID" id="30196564"/>
    <dbReference type="OrthoDB" id="1904319at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28137" checksum="CB8418BC45A05B5F" modified="2017-01-18" version="1">MGLDIFRQISKTNCYGGHSVAPMGLGFEGMLEKRILDDFTAAVGAGRVGEKKMLLHGMPAMLNHSWWGNMTECSFGDVMVMRASRHIAKGNELLIFKKMIWAKTPEEFQRHRAELAEPARNYIDTNDTALYACHALRIARFGLVSSNTVEQLNDWLLVARGGDIITLFSTIYDHLSASFRDRHDLLVVKPRLVERDLIQHVFRKVAAEQCKAKYYRVLVTGRAGRSIGGAHEEEFDEQRFLLGHEWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL4</accession>
    <name>A0A1E3IFL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028950.1">
        <property type="nucleotide sequence ID" value="XM_019179032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL4"/>
    <dbReference type="GeneID" id="30196225"/>
    <dbReference type="OrthoDB" id="10408670at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11815" checksum="B4D71EE646D1BE8E" modified="2017-01-18" version="1">METAGICEDYKKAFERVVSSRVGTLDPTGDFYPVLEGNPEFQIDREAMAETKTTVFEEYQTFVDDAPINQVAISRAAAWEVEWSESHPSLDGQQRYESSGEEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFM7</accession>
    <name>A0A1E3IFM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028963.1">
        <property type="nucleotide sequence ID" value="XM_019179045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFM7"/>
    <dbReference type="GeneID" id="30196238"/>
    <dbReference type="OrthoDB" id="3257061at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="269" mass="28799" checksum="93A5FE41794247A9" modified="2017-01-18" version="1">MFLGDIPAVLAGLTWVETVCIARARASRCCVKIKGHGSHQSKGNVVILPQAASELLRLLPLPASVIANEIVVIWVASQAEPLTVDKIPKKLLTVRRDKIIAALQWLKENNPLYSDVSIDGNALTSYPEDGHLPMPCFNSLASASTEAEGAGYVPPATTPSQSSDASQPSEDVMVDVSGCVDSNSSGHHVDLRKVSALAAIKGGAQFLAYPSGSTPMQEYSAPTTFAALYPRLFPYGCGSFEDLPFIYSLFFFILIANLNGNIPYADTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIQ4</accession>
    <name>A0A1E3IIQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029288.1">
        <property type="nucleotide sequence ID" value="XM_019178805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIQ4"/>
    <dbReference type="GeneID" id="30195963"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="328"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="740" mass="82947" checksum="3317F0240D63954B" modified="2017-01-18" version="1">MPPRSPPGVPHDSPYAQHRHRAHSSSARTERDLSTSASTTPSQVFPAVNLDDHLGPAPVAADFDSEVYQAKLRALSIPDSPVASPADSSLPSHTPSPEHVPDVESEEYSYVPDTSSAPVVKSLTRLKDNDIHWRHHGKAASSHFILHFQELKHQSGEQSNFFEDLGQHKRQDFWHVPEWEVFVMDVGLNPLGYSIWPDEGLDQQLINAYFDHVNVHLPLLNRHIFQRDYDSGLWKSQQRFGRVCLLIFACGSRFFNNLGTFWHPAFSKTQGTGKDYSAPWLQYSAGWRYLHMALHMGQNPVRMPDLYELQAQALICHFLQAGTEPARVATIAGSALRSAQDIGIHSKVVLERLQPADRELYKRAFWCLFHLDRQGCAMLGRSVAMADSDYDLPFPEDLDDEYWSLAGGVMLQQPSGRISRVRVFIEVLKLDQILGQVLQLLYSSSRKTTRGPTTRRAAAIELDATLQAWVSSIPPSLRWDPHRTNHTLFRQTASLWTLHAYIKMLIHRNLIPPRRNVATHDQLSSLASCVTAALSICSISDSVLSRSLREGSKPGQALDISALFPAWLAGIVLLVSIYAVDQTPLERRRAENGIRACLRAARELEVNWKLGGKIADFMEQFLRESGRLDTRREAEERAFRQESGTPTKPVYSAPQGHESGVQEQGQGQGQGQGQGQGQGSSEKEAQRKLFESWVRMNTFENQMKGMKKVTLGQGEDGQGAGEGQGEGDEDWWGRVFGNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKP7</accession>
    <name>A0A1E3IKP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029455.1">
        <property type="nucleotide sequence ID" value="XM_019178548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKP7"/>
    <dbReference type="GeneID" id="30195705"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="904" mass="97834" checksum="E608E74D6F5B1E06" modified="2017-01-18" version="1">MDTTADDGSVSGDHDGARRRWGQLDTPRVRHITGIRIHQLTLPESLSYASKLVPETQQTIPEDYTLGESSRFTASPEPAQSSSHGPRPRTSSSGSTALRRDRKTSGDSLFRPRSSSSSTVTLESSSPVVGSMRTPRIARHRAPTLAGEALELGHTSAAKGSSAPDRLHGSLSEEQEMIQVDKRRLARCFVVLKLPPHPEARDQKLNCSASKRANEEMLYRTRSNTQPRSASKPASPTSRSPTPKMPSSPNSITRTVSLPGSGGPMRVRTSSLTSHASLKSPSSPFGSPRRSGLNLNQKGSLRTAPETRLPFPRGSSSSSSYPPLSASMQERPQIPFYISSIHPPSVFPRFTSLDPESDFAPWLGYGELASGVVEVEVWVQDGLDFQRARKGPEKGQEAGEGWKKLKEVGGLVDLGRLRKKKDGAVEPPNGIEFTLSFDPMGIYYVPLSESLPNDGDEENPAHKKRETRLKQGTGAGGLHQLVNLHAVIVDTQKSIKQVQGNVDRLLKEDVDHRALKREVSERENRVTVIKKMIEDVEQRTEKVRTRTSTLTTSHQTRRSNLSDADEYSTASYLQVSALSNEITSLDSERLGLQPKIHKLRAFHIQMLDSLFPIQILDPSILLYTIVGVPLPIPANPKDPAPPLTLPNHKIDERTTSSALALSAHLVQLLANLSGIPGGGLPYPITCAGSKSAVRDVVSVMQGARNFPLFARGVERYRYEYGVFLLNKDIEMLMQEANIRLLDLRQTLPNLKTLLLTLSSPSYIPAPHRLPSTLGNGSGGRSRSSTSIFGGASRETSGNWATDNTFPGGPGSWGISPASSTGVGGGRESPLSFTAKAHSASMGGHAGSPLAKTGLKGRRSMLGKATSEVALGRARGEGEEEGSGDEEEEKMVGDGLERHVRGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ING3</accession>
    <name>A0A1E3ING3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029665.1">
        <property type="nucleotide sequence ID" value="XM_019178227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ING3"/>
    <dbReference type="GeneID" id="30195373"/>
    <dbReference type="OrthoDB" id="2577265at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="354" mass="40268" checksum="0B8B4C3301D57FD6" modified="2017-01-18" version="1">MSVPENWAAYSDSNDRAKFAATVIYKWLLEKQIKNFDKAKASGVQDRIQKMKKAFDEALAIQKPTGEGVTEDDLARGIETWEAKIKEKCPFFFTLLPSLKDRNANITAQSSVHQMGDREVSITPSMARRVSSRSDIEDQSVGMEDEADENDDIFSVRGTRANSLSTNITSNNHGVADEPTSGARGAGSLSNGSRARASLNAQDTPTSGKGRREQLQGLFKDHSTANIKGRKEIAEQQAQAALALEQYKVAEQARRFEGEMTMKNERLKVEDTRYEARLKIEQEERQAKRKRDEDDANWRNVKAQREELRAKDEMAAKKWEFERELIKEYVTEGDTREEAKRKAIEDTKRRFTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INL2</accession>
    <name>A0A1E3INL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029711.1">
        <property type="nucleotide sequence ID" value="XM_019178273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INL2"/>
    <dbReference type="GeneID" id="30195419"/>
    <dbReference type="OrthoDB" id="2563446at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="541" mass="60045" checksum="9168F767CB7A8F0B" modified="2017-01-18" version="1">MPRDLGQRAQDFREKWLAPSGGWLGELVIFISDLTGVWDVLIIAGVFVCAWIVVRTSPMEISMVLAFVFDLTIPLQYYNNEYLRKKHAEHLENYWPSLMMGCLIEGVCFFLLHPDLFTLIVCLKTSAMTILWMIRDQDGLPIKVQSPFDPSGRRSSGGGSVRDSDGRSSSRRSGGSDSPPRTSRDSSRTSSTRPETSNSSSSRPPKPSSSSQAPDTSERSESKPSSSGSSTPSNMPTSKNVSNPYKYLHRAGYSDPAIAGMILALNAAEKDRARKQMNAWVQEKDRKEIERRDKRYSESAKKAGWPKKFEQGGEGSGGGKTTLAIPQEAIEKAGASMKSKKVPSEERKKVMDLLKHPKSEKELQAAGKILKEMGIPVKLPKGGEGGESSSSGHKMGESDGHGGYRDIKLSKDTVQTLNQAMAQKQWSKEDHVKWLAYIQRPLSRREFERKVIPLAKSLNVYIGGGYTGGGPHRFDVKKLAEIKGKIKSRCGVDSGMADHMIVHAINQRTSKEAQDMLNRWVSKGIKRDEFEKLRRPAPDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INW3</accession>
    <name>A0A1E3INW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029525.1">
        <property type="nucleotide sequence ID" value="XM_019178369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INW3"/>
    <dbReference type="GeneID" id="30195515"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="363"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="852" mass="94641" checksum="11F88AC8877951D4" modified="2017-01-18" version="1">MSPTHSLPPDPPSPRINPFHLLSHPDPSHPLPDLPARLQARASQADPHPHPESRSPPVHITKVSAAQVTLRSHAEATNHKTFLARVSGAFKRDSGESDSRFGTSPIVMQGAPPSPPPSDGGMGDSVVVSDEDLPATLSSNGNHSQTGDARPVLATSFTSEPSDFDSHVVLAPPIPAARRVSGSSTTSSRAGSLALVRSGRLAPQRDGENPAKTKDLPSLPNGSDVELERRDSAGNLLSPIPMLHRRSTVGSTIPPPPPAPRSPLMHSRSAFASPSSMPPPAQGKNGFLDSAIQEQEETIRRERFSRLERRSKKASATSDGEHEPKPEDISSQHYSPKQQAPPPRQPLDKEKEEARVLVGNLIGEDHVNYVLMYNMLTGIRIGVSRCQAKIGRVLTDDDYTARHKFSFDIIGNELTPSAKYDFKFKDYAPWVFRELREQHFNLDPADYLLSLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTISHHEHKFLRSILKDYHEHVKENPHTLLSRFYGLHRVKLPRGPKIHFVIMNNLFPPHRDIHETYDLKGSAFGREYPEDKALQNPRATLKDKNWVNRGRLLELGPEKRALLTSQLKRDMEFLRKIRVMDYSLLVGIHNMERGNRDNLRNTQLSVFHPEVTTTRRKPSTHNGGHEASNIRKVVRRADPKTLDVTSQLPSEDAPDHADLIFYQDEGGFQATDERNNPLDTIYYLGVIDICTPYNTAKKVEHCWKSMTEDRHMISCVDPVQYGQRFFDFLRSVMRKGDLSLRPPGLEPIAKVDRLDVGQDTDRDPCAGIDTTAKTSGGADQGGGIEGLNSAEVLRDAPGIALRADGAEAPEPAMVGHLKADQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQD2</accession>
    <name>A0A1E3IQD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029922.1">
        <property type="nucleotide sequence ID" value="XM_019178203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQD2"/>
    <dbReference type="GeneID" id="30195349"/>
    <dbReference type="OrthoDB" id="10618044at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="421" mass="47185" checksum="42E6AC5525E063BE" modified="2017-01-18" version="1">MPRPSLPPIDPSTPPELICPCRKRVRPQLGASCEFCASKSKRQAAKRLEGRQKGKVARKLSELNEHPVFSTKVDLQTAAMSLLRAHHASPETFIHAAGHADEPSDEVISIRGSYQSPVEIQAAWSVPPGERPLNFGDAEQFLRRIGPTIAGVDTDSPYKFTYHDIPHSTDIPDTSTDYDCVARFICCQSLQSKRNGREKEKDPSKKARLGRTCMRRFDCQGEMTLRYDFALNALRLCIKHSIPHVTYQSVTFPDEALTVVERLVADGTVDITPIMQRITFKFPHLTWISRAQVRNAVRETLSSRYLLDKEPIQSLRAGLAQAAENGSVGLIDIDVPGVTAIAWAVLPILDEIKRRHLTVEEAFMDATCEFQERAVTSNTRDTNTQREKRRGKGRWYVRFYDAMKAVASMKHGEPGSSADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQJ7</accession>
    <name>A0A1E3IQJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029910.1">
        <property type="nucleotide sequence ID" value="XM_019178191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQJ7"/>
    <dbReference type="GeneID" id="30195337"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="32016" checksum="C18E36610E0FBEC2" modified="2017-01-18" version="1">MVNVFITGASGFVGSHLTPILLAAGHKITAIAKSDASAKKLEDQGVTVIRASLEDTNALAKAASASDGVIHLGFIHDFSNLAHSVKVDFAAIEAFGKALNGSNKPLIIASAIPVTGIRNPSELSPGTQPPRDKSEHLTTSFTSSGVRSHVVRLSPTVHGDGDQAFLTHYVQQSKKAGFAGYIGDGETHWPAVHVKDAAEIFKLALESTTLKGGEILHAAQDAGVAFKDIAAAVAGRLGVETKSITAEQAGETYTWLGGFIAADTVAESQLTRQWLGWEPKEEGLVEDIKSSKWYFEPGTETKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRD9</accession>
    <name>A0A1E3IRD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029793.1">
        <property type="nucleotide sequence ID" value="XM_019178355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRD9"/>
    <dbReference type="GeneID" id="30195501"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34770" checksum="B0C88C7F0DFC2CE8" modified="2017-01-18" version="1">MASVANGRQRKNPNRAARPSKPPSIDSLSHLSTIPDADAPASPISEESFPPPALSTQTGTGDKPIVTRRRRSSSVKRKPSPGVTPTKVVDWEIPRKTFHSSIGFVTLFLWYLDPPSVGPLVKVLTALLVGVSITDFLRLRYPAFAEVWEMVAGFLMRESERDKVNGVVWYLIGVIWVLVLYPRDVAVVAILTLSWSDTTASTIGRLWGRYTPPLPAHFPGIRLLPFAPRKSLAGFLAASVTGFLIGTVFWWNGSGGKWTVLDVEDFGHGYWGLWVTGLVVGVGGAVVEALDVGVDDNLTLPILSGALVWGWLSITNYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRW0</accession>
    <name>A0A1E3IRW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029973.1">
        <property type="nucleotide sequence ID" value="XM_019177934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRW0"/>
    <dbReference type="GeneID" id="30195070"/>
    <dbReference type="OrthoDB" id="10465594at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11366" checksum="055364AB7EAB6563" modified="2017-01-18" version="1">MSSIPQPVAHPATLSRFPMRVPRWRELVPIIPTAWPGRDDGFHGWLLDLCKDIAGQDGRAYDKWIDIEYKEIDSLELPPEEVNIARSLAKKRLMTTGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRY3</accession>
    <name>A0A1E3IRY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029993.1">
        <property type="nucleotide sequence ID" value="XM_019177954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRY3"/>
    <dbReference type="GeneID" id="30195090"/>
    <dbReference type="OrthoDB" id="2573285at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="20362" checksum="4DD91E0C6D5F0E7F" modified="2017-01-18" version="1">MSHTHGPAPNATFPAIIWHPSFAPGQQGQGGKSNGAGQVDSSNVLRPWAPAGDGTQGATKDVSSLSLSNNQQNPPAYYVAYPELTCLHCLGANPPGKLGYVVSYVPADAQGNPLPPNSSSSSTKGTTQALPNGSGSNVNFPSTTSALGDDRRGRGRGADQGQERRQRSTSAFRAGEILGGKSYVPDEGEEDQVGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS61</accession>
    <name>A0A1E3IS61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enzyme activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030089.1">
        <property type="nucleotide sequence ID" value="XM_019178050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS61"/>
    <dbReference type="GeneID" id="30195191"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="68686" checksum="9BDA19EC1F2FA27F" modified="2017-01-18" version="1">MAPSPPLPSYEALMDAENGGAPLSPPLPTPYAPVDYPTSPDPNAYNRHSAASLGRRPISDPNSIDFHNLEITPALPPNPVARHKTAPSHPHPQYRNAPFPRQQRSTTGGYPMDVDGAASVYSLDSGMGAYGGAGQHQQQQQQGGQGYGGYAPVQSDYHNPYYSAASDVLGLPPPPPQEQSFASSSTSLPPASQPHPVVTRQQSIPSLVRSNTAATNMSSASSRSIPPVPALPRVTEQVGASSTRRRGTQAAVDLNKPPYTKQYVDDYRKRMKDDPDPEAQFAFAKYLIEAAKKLGDEISHSDQKLGRKYRDNLLAESLRNVKKLAEGKVPYPDAQFFLANLYGTGQLGLAVDHEKAYYLYLMASKHNHPAATYRSAVCNEIGAGTRKDPGRAVLFYRKAAALGDTAAMYKLGMILLGGLLAQPRNVREAIVWLRRAASQADEDNPHALHELALLHERPGGTAGVLPHDPAMACQLFTQAAQLGYAPAQFKLGQSHEFGHMNCMIDPRRSIAWYTRAAEKGDSEAELALSGWYLTGSEGVLKQSDTEAYLWGRKAANKGLAKAEYAVGYYTEIGIGVKQDMDLAKRWYMRAAAQQHKRAMQRLTELNNQKNAKGKKGARPTRDDASSECIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS97</accession>
    <name>A0A1E3IS97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030068.1">
        <property type="nucleotide sequence ID" value="XM_019178029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS97"/>
    <dbReference type="GeneID" id="30195170"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN91442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="352" mass="37733" checksum="BC06C154D1AD331D" modified="2017-01-18" version="1">MASSSNPVILPSGTNSGLAVNIHPLAILNISDVWNRAQFTSSRSEPPKLVGALLGTESNREVAIVNSFELTFTPTGGDVEMSEGGAEKGAYTLDTEFLQTRESQFNDVFPSLKIVGWYSIGSQPTPDDIFLHKQIISSTSESPIFLLFNPHPAPEAQNLPLNIYESAEVAVTGGAEAVEGGDIKFVELGYGIETGEAERIAVDGVVKGGTAEEDSAVGHLTTQRNAIKMLFDRIEILQKYISGVVNKSAKPDHAILRQISSLVSTLPTMDAAEFQDELMTEYSDVQLSSYLSSLTNQLNALSEYGEKHSLLYGSKEDDYSGGGAGMGLRSGRGMNLGFGGFDLGSGGRRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISF7</accession>
    <name>A0A1E3ISF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U2-associated protein SR140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030094.1">
        <property type="nucleotide sequence ID" value="XM_019178055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISF7"/>
    <dbReference type="GeneID" id="30195198"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="210"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="454"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN91468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="728" mass="81081" checksum="E5A41ABF3130AF29" modified="2017-01-18" version="1">MSGRRIDLAKFAGSDSEGEDSQPKRQLELTALKSKTFSHGITKKTKRDMEKEAEEKKRVEEEKAAALVMAEFEEEFNSGPSHPNTSMRGFGGGSNAAPMGPRKGFVKAGGAPMALQALQGNTGFQPPRGPAAMGFQQAPPPHVRPVAPSASNGPMRKKRAMDSFLQEIKNNQDAREQRLGNMAKKEGSSVSALAAWESETKNGVLDLQTTNLFVSNLPRQNMTEDTVGLYFAKIGPVGTVKIMWPRGEDNLSFQHRGLSGFVSYMSRSDAETAVRELEGAEFQGNKLRVGWSKAVPKPSKALYGVSGQPLRLVETDRKERSQSPPRKRRARSYSYSSSSSYSRSPSPRRDSDGETWLKTIPEEKAKFVKAVAERVREHGRGFEDVLREKEKDSEKFSFLFDDKLPEYHLYKSTLSSRYRIPNPPHTFIDEGYASMYSSDSAEDSEKERTSKGKLGRLAKRRFEAMLRVMSGKRGEIARAMEFALTHAEAADEIAETIVQSLIIPSTPVPRKLARLHLISDILHNSASPLPNVWRYRQAFEARLPPVWAHLKGVETSLEAYKGRISADVFGKSVGSVLDIWERWIVFNTETAELFRALLLGHSSLDSLTRTPQGMWVDKAVLEAQDEAKRQKAEEERRAREKKEEADQRFKSGGFKSSFKRVDPSSNAGESTSLENHPAAEQDLDGEAMEDLDGEEMGLDGEEMDLDGEPFVSEDLEGEVMEDLDGEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITS8</accession>
    <name>A0A1E3ITS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030154.1">
        <property type="nucleotide sequence ID" value="XM_019177770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITS8"/>
    <dbReference type="GeneID" id="30194904"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="296" mass="31456" checksum="D09C4269B4CACF68" modified="2017-01-18" version="1">MSFTPTSHSTPTDNTAEPLVDKSELPTIELSFSSGPNGAWDDRELINAANSAMKEFHTHHPGPGSWLDKATAAMAIGKPLPGGNDYGTAWYTASTPVVQDPPAAAAPPKKKRKTNTKKTINPYDPAATAYISQTNGPTSISGPSNANARAESPSFQPPSPGGTEDADAKRAEEDAEDAEWGYVEEDWEEEEGDWEGDGQGWEGEVAQGAPQAPPAYGVQSADGVSREEALGHAMTAQYWAGYWMGVAQAKGGESAKPRRRKCSGEREVGATSSEQAPPANMIISRHQYDGVNGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU68</accession>
    <name>A0A1E3IU68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division control protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030284.1">
        <property type="nucleotide sequence ID" value="XM_019177900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU68"/>
    <dbReference type="GeneID" id="30195035"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000365">
        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="966"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122413" checksum="A78A523E08AFEDA7" modified="2017-01-18" version="1">MSISGTISRRRIGSVSQRVNDSLPQLDIQSIQMPSNPQNALALKTAALSTSTRSLYQTCSILKKRLMCVEGFQPFLEQPPNAEPIDVVSHMCHLFRLGSPLLHLYNLLIPAFTDSLSPLYADLPAPAKLEYAFPQFKATPNGVRNWAKKPENAKPCQRYIAAFCMAMKKRIEEGRWHSDMWALHELWGKSTGEELEAYDSTGLMKVLSTVEEMLDNLPESALSPISPHTPFTGNGSIAQRTQSRQSYDLPFSMGGMGSGAGAVANMAATMNGGVHIEASANENSPSTEEMQRGPSKMSAEANAYKSVEELVASEKSYVQELEILVRCSQEMVEARLVSTETNHMIFSNLSKILDFHRKFLIKLETEYEPMEEKGQGAWAEGVWGRPFIVSEAEFDCYGPYCANYLDAITVVNEQMPLLMRGQELALADRPCLDPQRELQAFMIKPIQRITKYGLLLDAILHATAKHEYPYRPELEEASAAVKRIAAGINEVTDFKAKQATIRELVERVDDWKGHDVDKFGPLHIDDHFTVTKADQPRGYHVFLFEKMMLCCKEITPDKKKSGKNSSMLRKDRGMSKSGPLDKKKLALKGRIFVSNIKEATLLPSEANADPYGAARLLIGWTIPLRTTDGYHEDQEDSFIMIGKSEDQMKKWSEKVLDLAKNERKVQEELRQQRMKSGRLSGSERHFQHSSFGPPTPASEFPPPNPFNMPPLPDKAAAHYHGEDDDPNGLHSGRTTPSTQSHPYAYQLPGGNRRVQSQQSISSMNPIETRARAMTEDQNGPNMAQWRTQQPLAPPMPRLVSNMSGMSMASEASFGNGPPSAGNRPGMGRQMSSVRLPRAPEEEAEKDESPTGQREAFNRYGPSRGMARTPSQGVATVPHPPALRNRSASSPNVYQEPVVIGAAPPVPYTAGANGTWTTGSASNLPSNTHPYAHSTPVPGFGPPPQGGTTVVGGTAYFNKRVSSGKRSSAGSTTTTETSDQTSPATPYGTSGDLRPTQLRQGSGDSVGGSVLVKVRCGEDQFILGVSHEIDYITLYQKIQKKLRLCSSRPAGEHDKLQIRYVDNDGDEIQLKFDSDVEMMMEDGRDMAGQINLIARWTEGAGKRLGGEVYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU83</accession>
    <name>A0A1E3IU83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030139.1">
        <property type="nucleotide sequence ID" value="XM_019177755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU83"/>
    <dbReference type="GeneID" id="30194889"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="414" mass="46500" checksum="0079CCD56686F1AD" modified="2017-01-18" version="1">MLLNPEQFTIRPATDGQALQHGKACFEVPDWRARMSLEDFNAIAEREQSEAEYAKDHGVIGWVLVRWDDYEGEIYSALETQVTALNPVSSVAHATYTAIARNASSRTKARVKSGTAGCQGYATHLIRLLHYILTSPSPTITQPAISQTIPPFPPSWGQRPPPIPHELVPYVPRADGSMLWSDVLMRVYERCTLGLEGRGFQSKQEWNHTLTWKLNGTSESQSDWEYIWESDLEDIYPVVWANSRHKLSQAQTIDKPVFLCDPASPGTLTMIPVRGSYSPQPTWRTRVLPYGIRLRATKGQGWEYEAVVLFSLYNSAASPRLCVTYMQNITPGLLPALLTSLDGVVEYSGAPWTEGEVWGLDPTSELVHAWNRAEGRDVVVSTRIGTEGMVHVLGVCWYDEEEVDMVDSQMWAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW67</accession>
    <name>A0A1E3IW67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030425.1">
        <property type="nucleotide sequence ID" value="XM_019177674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW67"/>
    <dbReference type="GeneID" id="30194806"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="582" mass="64509" checksum="E5C8A7BE7FAACDE8" modified="2017-01-18" version="1">MIRPRTLPSTRPSTSFTPRLPLPRPSSRGIAAPRAFSSGSSRRRYLPLTLLPAGLLLLPSLSCDSDPATSPPQSPLTIAPVSELLRSWFVWAMICTPGMVDCSPGLLSIISRTPLRRPVEWFVRHTFFAQFNPGETVAECMSEVRSLRKSNIGSVVNYSAEMDESGLHESGAEKREREEKDRQRRLEQVVVALDVMGEFEKTLPLEQRGASGLALKMTGLIDANVLERASYTLLRMRYAAPLTPITTPNSAAFVPYPGTPESADGQVLARDHMKKLVDPKELFSLQGKVDAMGTKVEDVRLKEGDLEQLATLWQKLRMLGQRAKDNNVILVIDAEHTWYQPAMDAYTLLLSEEFNRPTGNPKDISPVIYGTYQSYLTRQPTHLLAAIAHAEANGYALGLKVVRGAYYLQERKKWADEGRVGNDPIWPTKPATDLSYNGAIDTLLSTLSGQLKGKHPERALSVVFGTHNTESTDSICENLIKYGLAEKDKESGLLRFDPAAKGHVRVAQLYGMKDDLTNSMAGRFVNDGNPVAYKYISYGALAEVMPFLGRRAIENKSMMSGEQGAAGERKRVGRELWRRVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY67</accession>
    <name>A0A1E3IY67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030473.1">
        <property type="nucleotide sequence ID" value="XM_019177722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY67"/>
    <dbReference type="GeneID" id="30194856"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="273" mass="29918" checksum="06157A8C96CA0E31" modified="2017-01-18" version="1">MPVIESIKNKLHHDKESPETTTAQQTPPTPVSPEITTGASASEQAAPAATAELSDKPVFDANKVTVIFVLGGPGAGKGTQCERLVAEYGFAHLSAGDLLRAEKNREGSTYGAMITEYITEGKIVPMEVTIKLLENAMSDILSTPPTTPGWSNGHGRFLIDGFPRKMDQAVKFDESVCKSSFVLFFKTSEEILLERLMERGKTSGREDDNKESIVKRFRTFVETSMPVVDYYRARNKVIEIDSSPPIDQVYAEVKVALDERIPKKGAAYGDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B4</accession>
    <name>A0A1E3J0B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030779.1">
        <property type="nucleotide sequence ID" value="XM_019177198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B4"/>
    <dbReference type="GeneID" id="30194317"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="547" mass="58577" checksum="6FC51CCAAC84D344" modified="2017-01-18" version="1">MVAEGTDTSQGVGQLLSNISACTAVAQTIATTLGPRGMDKLIVDDRGLATISNDGATILRLLDVVHPAARTLVDIARAQDAEVGDGTTSVTLLAAEILKEVRPFIEEGVSPHVIIKGLREAKSLALNKIEEIAVTIDKSNPEKFRDLLMQCAATSMSSKLIQTQTPFFANMVVDAVLSLDQNDLNESLIGIKKVPGGGMQDSKLIKGVAFKKTFAYAGFEQQPKSFKNPKVLCLNVELELKAEKDNAEIRVNEVSEYQAIVDAEWSIIYRKLEAIVATGAKVVLSKLPIGDLATQYFADRDIFCAGRVADGDLKRVVSAVGGSIQSTCSDIESHHLGQCGAFEEKQIGGERFNLFEDCPEAKTCTLILRGGAEQFIAEVERSLHDSIMIVKRAIKNNSVVAGGGACEMEVSKYLRGHSRTIMGKAQLIVGAVAKSLEIIPRQICDNAGLDATDILNKLRMRHAQGDVWAGVDVDGEGVQDNMKSFVWEPALVKTNALGSAVDAACLILSVDETVRNPQSEQPQAGPPMPRGAAQQALRGGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0E3</accession>
    <name>A0A1E3J0E3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030536.1">
        <property type="nucleotide sequence ID" value="XM_019177383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0E3"/>
    <dbReference type="GeneID" id="30194509"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="58758" checksum="EC3A54A19A911378" modified="2017-01-18" version="1">MAAVTSASAYPPLASSTSPLDYGYTSSVSPPLQGQDGRVTTPLAAPPPPPLHMSSHRHVPGPERQIRYAGADHTLGPTFSEEEDGDDSAFIAAKMAALGLDPNGNPYNQNGYSGATRAPKERRSRTPVVSRNHEPVNYQQQQVLIDLLSQQASPSHIRESMALLELQQAQHAATDRHYQTQMLAQQHARSAAQRQAEEYQRDLYIQQQAQKREMERLAIQREATKRQFLQQQQEQQMLKLRDQRLQQLHLQQQLAALQTDAYQAQVQAQRQRSALGAQMTANLQARQDRAAQGHWGMGMDSADLKSRFESAPQSAISPTSEDRGRFESAAYYSGYEAPSAVSGSPTSPSWRSSESSSPTKSVSAEGPVPAVKPGGRFARARAALEADGKSSYGTLSAALSKRSSSEDHISAPAEVSIPPADVSHTTPASPISKRVPIALGIGRPVVAPPKIIQSGEKYTPRAFSLPQGPQGGRGAQAEGRSASSPAGQVKRVVVTVARQPTGPPGDVKDLGDKNFQARIRSQAVRNLGMLGRRTDFPANDLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0G8</accession>
    <name>A0A1E3J0G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette, subfamily F, member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030880.1">
        <property type="nucleotide sequence ID" value="XM_019177299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0G8"/>
    <dbReference type="GeneID" id="30194419"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="184"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="515"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="732" mass="81798" checksum="CDF85AE476D01F33" modified="2017-01-18" version="1">MAKIASDIRRTFPRTDEVVVSYIAGLVDDEEEEVEDIVDMTKGMLSGGPSSEDTTKNLDDFMSRLLEYLDSQSTKRVRKSTTATKLDKTIHMRSQAMSATIAMSGKVDLESNTKGQASRVDLGKLAKAEAKLQAKIQKRAKKDNLYQGSKLIEMQNKQESYEEMFMKVNPLDVSGAAKGKSKDINLPSIDVSFGSNRILSGAQLTMAHGRRYGLIGRNGIGKSTLLRHLALREVPIPTHISVLYVEQEIAGDSTSALESVLQADVWRHKYVTEERELNVKVEALEKEGLQGGLLGEDKVRIETEKEEALTRLGEVQKTLVDMDAETGPARAGQLLNGLGFSDEDQKKMTSAFSGGWRMRLALARALFVKPDLLMLDEPSNMLDLNAIAWLEEYLQTWPSTILVVSHDRAFLDHVATDIVHQHNQRLDYYKGNFSQFYATKTDRAKNQKKEYETQLTYRQHLQAYIDRWRYNANRAAQAQSKIKILEKLPELEPPEEDDSETFKFPDPEKISPPLLQLDEATFGYTPAKLILQNVNIDVQLDSRIAVIGPNGAGKSTMIKLLTGDLQPITGRATHNSRCRIAYFTQHFVNQLDMTVSAVAFLQAKFPGKTEQEYRSHLGSFGITGLTGMQKIDTLSGGQKARVAFAVLSMTKPHILLLDEPSNHLDIEGIDALIEAIKVFKGGVISISHDERFITNTSNQLWVCADGKVTKFLGDVESYKKIVTEELQAKLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1H8</accession>
    <name>A0A1E3J1H8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate phosphatase phospho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031002.1">
        <property type="nucleotide sequence ID" value="XM_019176970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1H8"/>
    <dbReference type="GeneID" id="30194079"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="241" mass="27129" checksum="F4F16E216F8FE26A" modified="2017-01-18" version="1">MSKQLIVFDFDWSFVDQDTDRWVFEVLSTELRRLLQTRKSGGSQCTPDVVNDTMKDLYERGFKKEQVLEALRILPFHPAMKRAVLAYKGRDANNSLLCLSNSNEVYISTILEKHGLTDLFADVITNPAHWSESAPDHLIIGRRLPATEPPHGCTVGCLANMCKGDELSTYLAAHGGIDSFKKIVYVGDGGNDFCPLLRMRKGDWACVRKGMELDGRVKEEGAKSGLVAEVKYWDQAWQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2W3</accession>
    <name>A0A1E3J2W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031173.1">
        <property type="nucleotide sequence ID" value="XM_019176698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2W3"/>
    <dbReference type="GeneID" id="30193793"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="615" mass="67050" checksum="87DBDE74E6059E23" modified="2017-01-18" version="1">MAFSGALTITDLDDFLTPSQACIIPVRNNKSAEAEGPTEIHIDSNNNYYEVSTVPTVGNDFDDPSSSKKALEKAEINLNDCLACSGCITSTESLLITMQSQNEVLDFIKQNQHTHNADEPSHKHRRPILSISPQTLSSLSAAYSTAASLPPIPLLTLLRRLRAFLGQPEQGGWKVWDTTFARHMSLKETSVEYHERKDRKGKGAEMPMLASACPGWVCYAEKAQGDMLPLLSNARSSQGIIGALAKSWYGAKANHKPDEIYHVTAMPCYDKKLEASRSDFYSSLYSTRDVDCVLTTGELDLLLKELQFDPYLSVPNESTPSYTATDDSPFPELLTHEGSSSGSYLQTIIRDVQNSHINPTRTTTREIRGSTDNVEYLVQDTVTGEVIFKGAKVYGFRNLQNLVRKVAKETGIGRSGRGAGAGKLSAAVAARRRKAKPAAAENGIAALAISGEDRKLDFVEVMACPGGCVNGGGQMKPAIAVKSDAMEVDEEGFQRPMADDGVEMKVGQEKTVEGMEEGMRWSTKEWVAKVEDIYWTGLPTPPPSPTLTASEPPTNGFTNGHVDRLAASDLLAEKIVREVCGESSEKRQDFLRTGFSKVETDVLNSGGITHEAVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J311</accession>
    <name>A0A1E3J311_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031230.1">
        <property type="nucleotide sequence ID" value="XM_019176755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J311"/>
    <dbReference type="GeneID" id="30193852"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="942"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="682"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1078" mass="122871" checksum="A71D202F2A291609" modified="2017-01-18" version="1">MPPTSSMAALMASPTTSGGDATLMANGQTLPDISLGSLGSSFRSEDEDERLEQERARSNPNPTSRARRYSPETSQSRSNATPSPPRAALLTVSPPPTIRKSSSHSVLNTQAPRRPRVLHRRTSSVAASSDGSDGEDITGPLEARYGKADEETDDEAMLSALSLVPSPRKTGGGGKRAYGGASGRSGRHSVAAGELNGPMTLRDQEKQLEETKKEVFNLQLENHFLKERLSNMAPEHIEAALKENVKLKLEILTLSKELKKLKKLVMQQDRDLAATARDSGGSREARELEKLWKDEKERRRRAEEQVSSLKDELQSGAADPELREKLEDAEASENVWRQRTEQLEQELDDQRAANDDNQEEFAKLRDEADRALDEVDKLRGELDGARGMRESVGLGKGRETRLAQKVQELESQNASLQSDLSMAKKGVMSEEDAEMLEERLNELQDKVAALQLELDNRDQEVDDLNVELDAKVQEHEKELQQVAEEWKDEVLEARAQVDEVRDVTLIEREEHLTSALEEISQLQATKAVTHDRLEETLKNIERDNVEKDAELMDANREIEELGQKVYELEELVEDHRVREGELNADLKGADEAFEHAKAHYEELIGVLKEARRKLQQEKEDALDQIRKERDARQAEKDAAKRDLDAHSSRHRQALAEKDTYSARLQSELDAARERVTLRDRDLARVEGKLQDLEDERRKLGDEHTSDRFGLELELERVQRDLQRLEDELEIERKEMDQKDEMLREKDLEAAQMLDKHRDIENRLASERQGRLNISDKLDQTLKAARQHEREANNLRERLEELEPLLTETQQERFQLQKQSESQRQERSELLLRVFKEVNKFLGTEDNTTPANFALFRDTLVHRLKSMLSVRSEFDKKIKDTEASVDQRMSSLKRQLEQKWRTLDQFEASVKKLEITKREWRSKFAIKEGELDALKSRNTELSSQISTLKSGSSTESSSQLRSLSERAQAAEKRAQTASNQLAALEERLAEYQGRYGQAESKWEARVKEYENRLRIAGEKIKTEKQGGKERAMQLEAQVRELEKQVHDAQKRNQRVEGVVASAGHLLPGGNERGGRMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J340</accession>
    <name>A0A1E3J340_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031244.1">
        <property type="nucleotide sequence ID" value="XM_019176769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J340"/>
    <dbReference type="GeneID" id="30193866"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="254"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="749"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="883" mass="96733" checksum="BAAB05C23FC5837F" modified="2017-01-18" version="1">MITLTPLSASANESSSSEPISYLLQLDDARILLDMGQRDYRASAQQTSWEYEEKVRELAPTLSLVLLSHSPANYLSLYPYARARWGLTCPVYATQPTVEMGRVVEGEEVSRKPLKGPLVATSEEIHEAFDWIKSVRYNQPLHLGGDCSHLLLTPFPSGHTLGGSLFKIRSPTSGTILYAVGINHTSERHLDAQNGPTGYADGVQRPDILIVESGRSLITNPKRKQREAALISLISSTLESNHSLLLPVDPSPRLLELLVLLDQHWTFKREMAMWPYPLCIVSRTAQDMITFARSLIEWMGGTVKDSGDSVVETRPGKKGRPARVQLGSEYGALDFRHLQFFASPADLLAAFPLSQPKLVLAVPPNMSHGPSRFLFTEMANAEGNVVLLTARGEEGTLGRDLFGKWEEKQGEGEQWGQGKIGKLATLDGTLQVEIDSKVPLEGAELEAHLESARLTKEREAAQKAALERSSRRMLEADDLESDSDDESDDGALAGAEEKGELGGATVKRAEGANAFAGDGEDVRTMSFDIYVKGQQMRSGRGAEMARFRMFPFVERKGRKIDQYGEGLDIGQWMRKGREIAEEGETEEVREARKRKEEEEEKAKVQPEVPSKFVNQLVSVDMKAQIGFVDMDGLHDGQSIKTIVNDLQPRKLILVRSTQEATQNLVTFLHSISGFTKDIFTPSLDEEIKIGTHVASYSLTLGDSITSALAKKWSEFEGYEVTMVDGKIILPAGSTIPILEASHLYQPLPKTEEAEGDEAAEEDVKPSAAELEAPPKEATPPPSAPTVSNLPLTLPTSTFIGDLRLARLKYRLSLLDPPIPAEFAGEGVLICGPGVVAEEKRKGGQVVAVRKVGEGRIVVEGSVGRIYGEVRKAVYGGLARVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J381</accession>
    <name>A0A1E3J381_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031289.1">
        <property type="nucleotide sequence ID" value="XM_019176814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J381"/>
    <dbReference type="GeneID" id="30193917"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="39211" checksum="7649A4A4D086E953" modified="2017-01-18" version="1">MSRPTPNVLINRNLRPAGASGNVGAGASISSSLLFSPNYHHDSDNAYFPPLAIARAGGKGGQIFVYSEDGTTTSGYSSFAGGGRRWGDAIAGESTENTRESPPSYLHQHFSQFADTTTSQSYRPPSNMPISHNLITPPSSFTQSVDIPGARGQPSVRPMSLPLTPLSSSAARVGQESPEHSGSTPDSGKFDNSIITLITSIFPLHAQTVSLLSHTLEILTPPVHKLQGFIVDYPSSYTSGRTVFIHMPPGHGTVNQRPESLSPNFSQVLRPHDPLFSTSPTSASHLASSAYAFDIRESLTALLDLAAEALEGNHLVLVLERNEAEQEALGEMLHSLMYVGGQVVKPGGLEGGWEWDATKWVLVGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4W9</accession>
    <name>A0A1E3J4W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031595.1">
        <property type="nucleotide sequence ID" value="XM_019176667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4W9"/>
    <dbReference type="GeneID" id="30193762"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="765"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN95930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="838" mass="90069" checksum="CAA4CE7227983499" modified="2017-01-18" version="1">MASSFAQMSSEKLAQLQTQLPDILTDAEKLLPEEKRNEVIRDKMLARIMAQGQHKMQQQGAGMGMQSPMMGMQQGMQNGKIPVNQSQLQQQQQQHLAMQSRLQQQSAAAQQSRTGTPRPTQPMTPMPQGPINTASPQSHGGIVSPQVIRQSPSTAPGRPVGLPMQGIKTLIDNFPKLMELKRQGKLKPEQERLFDQFMSSPDGQNHLREFRAHQARLLVERGLTNPVAHPAGLQPQQTPAMNNMQLPLAAQQQLAALQQQQQQQQQNQQPFPLNPQTQSQSLQNQLAPQFAQNLAGAGLHHNQNQLTPQQMQALQLQRLAAAQMQAAQNGGRAGMGGQGLVPNQAMINQAALARAAQQAQAQQPQNGMMGMSPHIAAQAQAQGQGQGQSPGGFGSPRPGARPPMSLQQMLINIQPSMSRVAPDKVESVKAMLMRLANMSDEERDGAFKASPQWIPLWNRATGGGNQNQLAQQAAQQAQVQAAQQAHAAAQAQAAAQAAAAAQAQMTGSPHVGLQNGTPIMRPGSAPAVAGFNAINNVSNLHIPAGKARGLQGQGVAAGSPNMRLLQPAGDGQQQLPPGLQADPSIVQRLLEQGIPVQQAAQVFARHQQQLAAAAAAGGNPAYPGLAAQHPSGGTPQPQRNITPAMLLAQYSHDMPSRPPPSRPEQIVPDAPAPTDQSLSILSRASWVPNYTDDVRVESMFKPQTVAETGSRTVGRGTLGWRRVDREGVDDWPEGLREAVDEEAEDEEGEEGEGKGRASGMPGQKRRKVQEVAEEVDKALKIPKDSETLLLELFDEHSDVISEASCMLAKHRRATTLDRKDIQLSWGKSPPSSNSLAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J521</accession>
    <name>A0A1E3J521_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031196.1">
        <property type="nucleotide sequence ID" value="XM_019176721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J521"/>
    <dbReference type="GeneID" id="30193817"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8646" checksum="2ADB662977216350" modified="2017-01-18" version="1">MSAVAPVNPKPFLQDLTGKVVYVRLKWGLEYRGYLVSTDGYMNLQLANTEEIENGKSNGALGEVFIRCNNVLYISIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6B0</accession>
    <name>A0A1E3J6B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cohesin complex subunit SCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031646.1">
        <property type="nucleotide sequence ID" value="XM_019176236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6B0"/>
    <dbReference type="GeneID" id="30193327"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="579"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN96400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69384" checksum="E55EE47AA3C67E82" modified="2017-01-18" version="1">MILNELIKSGPLAKVWLSAHQERKLSKTQALGVDVGESVEAILEQDAELPLRSSGPLMLGVVRIYSRKVGYLFDDCKEARERISLAFRPGVVDLPEHQVLASHNAITMSGRGDFDFNDWSWDSTGVILPPETSQAVPAISARNPEFGGFGYGAPRPSSVFGGSVTTQSRQGSYDESSSQMGSNDFSGVDLGLGDFDGNDTIEYGRDRMSSLGREGSAFGMGRGLSRGRSGSARSEIDYTGIGDDMPLAPMDDYDPMAVDGGYEPMDLELNFDQEQEPERVARASTEALTPPPATPAAADNDLTPRTAAQIAARPAPIAKPVKRPRLLMPDEALEIDQTHQDRASILRPENYIPANPEFAQMKDIFADPSAHFLPVFKVGGENWTAVAPLGAVDDIIELFSFPNNVLRRGRALDEPDDEQLAKKARIEAQDEAAQRGDEPADIDTDDVEVVRRRDFRVGVDPGDDHAAPFVADDYDMSFDVDPMDGDMPAMSPLGYRASRAPSLALSRAESIAHEIQYGVDSGDFTLAMFDSRHAAGSQLSQTTSPGGVGDGSLGAPQGRNSSMAMGLLRKEISAIDEGEKEVSFEKLANNATKRAASAFFFEMLSLGTRDCVKLEQPEPFGDIKISGKDKLWPASSQIPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6H7</accession>
    <name>A0A1E3J6H7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031715.1">
        <property type="nucleotide sequence ID" value="XM_019176305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6H7"/>
    <dbReference type="GeneID" id="30193396"/>
    <dbReference type="OrthoDB" id="3245754at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="74598" checksum="EEBDCF9B724245B7" modified="2017-01-18" version="1">MDSQQLPSYSPPLTKPSPSPCPKAVRSTRHISSDLLSSITLERILKEETKSPVTKKDLLRWLECRVRKAISSGDQEEAREAEFGWRVVEFLSEVEMYKESFNALPAEKASLALPPFQVISQIALTNSEIMLPPPTRRQQGAASLGQDHEFNTFKSPNVGHERDKSSIESFETWSSDSSIPRKRLERSPSDATTIEDTPSLEPVTLESNRPELTSPRRVLPKAHNPRSPSAASASSTLGISGLSMATSYATGSGRSTAGGLARQAFTAGGLSNPSSYQREMDWDRRDTMAPQAQDPLAPPPPFESTGLGSFRNGLSPRRPTENMLSRPLSPIPSPFLSPRPLSPCPSIVSMELPAGLDPGVQPLRQRLANLTELYLLPYSSRSVVPLIPPRLLATFVSESSLTTHPETIGPTVTVLYEMFSVNPRLLPAFLYASAQNLHRNTAMGRLLVGLACCVVVIAIGICLILDPSPFSPHGPVNRVWRLAVIPLLLGGVGYGMGARASLCFWLAFFGVTEETYSPSHPPLPPSQALNLLSSAFICHLPCAFVRKTQRKIEPVAERITSRKLKKRSVSTLEDGNPFDPGDAAVAGFGLDMVSMSRSRSGSNPTPATHLLASSGSTGFEQYSIWVLLWRLTGTAWGVKKVEDPSLRKYQRREAWKIAGQLVLALVFIGAAFFFVPYIPLSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6M1</accession>
    <name>A0A1E3J6M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031750.1">
        <property type="nucleotide sequence ID" value="XM_019176340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193431"/>
    <dbReference type="OrthoDB" id="2591106at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="979"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="139034" checksum="306BCCCA9CC89F13" modified="2017-01-18" version="1">MAATTATRPPSPSFHAHNRRHYYLCGGHTLSWEEQWYTEPFFTSDRASYDSAASTGPVQPPESVYGSVGECSRVLSSLSTEGITGSSAVSASGSQTEEPQTTRVTTSIRSTFTSDGEVETTTYRSVITSTLSVETGSSDSSSMDSSTPTAVATSATTVSTATIPSVEPSEQVAGTLNTCAGEWDWQGWGAVAGLGSGVIVGGLLWLAWIFLRSRVPTIFSPKSWYSRPDLRPSATWSFFAFLLPFLHLPSIDKAGASPSEGDNALQVLLAGLKLSAIASVVALAVILPIIMAGVPCLRDTSPPNSLGGRLGALTDMSLVRLLNALDPSPDSPAADTFLAMLVSIGKKRNLPSTIAPAISSARTRLIVILVLLTVLSVGGGLFVVTRAYAALMRAKRVFEDETCHGVDMVWIDVQRAHGWAGLSEEGLRRWFKEWWKISFRDNRDQESEVEVFGLFAIPDTTELKKVVANREQVLLELEQLETRYIHSFKLSAPSSTSGGRGLEPVWSPKSIHSQSTRVADQMSPSSKGADFLGPKDSYKIGSVDNPPSGERLEFDLPTTVTTAPTGTKFHELNRDSILMGGRFQVGQRIKVDEHGNYVPDPSPPTSSESAGPGLGESDDMLGSAESGDFGRIPTRSASGHFAPMTTPADIGAISPNDADISNSYSDPALLGPQPRSHEEFVPRPGSSGPQASSHRHSGAPSTIAKTYMEVRELRSKFKELNTEVQRLQAGKFADISQSTKGQEGQVSSAILGWIVVGRGVKWLHGAHAIEGRSREDILWDQLGQTGRKSEMTFWAEVCLLGFLLMAICVPCLGLAVGTAPGFSYYLGLFKPLARSDDFGSGFVEGFVPVIILSLAMGTSIWFVETSGLQSDVLATSKSFSAVESISLTALQLWVMLIWVILTIALEYATQNFVLGVQKARGVGDGASWSSWFIFVLLLNIAFIAPGLYLLQGKRLLSYRLRKGKSVTPRKLFRLRQPPSYVLSYAMAPCLLAVFYASTLLFLFPLLAIPILLTLYLSFIANRYMVSHVFIDSSGGHLGTLAGLWTVRRLGWVLALGPVLYGLIMLSRNEWALAAVSLAVGVIAFLLAETLTSCRVPSPSYNNLKPDTRQALDRVKAFQRGSTTDSHLTRVPSRQSELSLFRRVAALLPGYTRLPPDCPVPLKTDKVDDMFQTELAAYSTPDLGPGTIVSSGLYQETTETKGLVYPPEMLQPVPLIWLPYDEAGVAENEAEDLGVHHGLVAIVDPVGRERDLDARMIHRRENRRVSGDGGDVDSPLLNQDGDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S9</accession>
    <name>A0A1E3J6S9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division control protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031810.1">
        <property type="nucleotide sequence ID" value="XM_019176400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193493"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="927"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1270"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1366"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1294"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN96564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1390" mass="153839" checksum="C50D2D5DF8F26991" modified="2017-01-18" version="1">MSGAQHDNDNDSHSGWDDEYQDAWVRAKFDFDASDRGHLTFRAGDIIQLLRKLDTGWWDGILEDTRGWFPSNYVEEISADDLHQYYDAGLGYPSQQEYEEGNAGLGGDRRGDAINADDLLRGSWGDDWGGAGLDQLAREMMENDEGGEDGLGFMLEAQRRKNSNNGLGIDLEEFGTGASGSRDETAFKPTQTTRAAQKAPDTTPRVEREDAWIPSITPDGQVYYHNTQTGEDSWELPMDDAYEADDPYAQTDEQFFHNVPSSLQEDIFKRSVEDSESGEFAVPHSHADLPYPWIAKLSDDGREWFFHNRLTGQSQRDQPHIGDAESLADMGLGLSRMSMIQGPPAIRKSLLLQRRTVEDWQVKTCDSLRAVTQPPNPPTLGILVEVIYDALREVLEATVTGSAAEEEMSRAIDLGSEVGLNAALDREEGAIEAVQAGYQATLQSIRDLLASFGYVGPLDPMEELPRPAWTSDLALVGCVGVLGSVVHAAVTSKRQAESGLSVWSEVLRAATKLKDVVSNYSSLLFSGQLTAAQRDEKEGKRVEGWLGFDPLSLGEALGGKWGFGREDKGYRVLDQAAVLDCQKARVESDVALQHLENVSSENLQTAVLEALRVAKSFDKIVAEIDIASQVDVDGDVGDWPNGGATREDDLQEYAHLVHQARLALMDLDQSTREVNEWSVAILNALSAQRGISAELESLTTTLTTAFRALPTLLIISREQRAANEQGLIRGQIGIRSPKHIATSQHTRSTSLASTASRGSRLSDLVRRKVRGLVDEPEIYGDAYEARDRPSEMPSSASQSQASLNNNSGTRRTSASSSVSSLTYQPTESDGTNSQKGNRSSILRAFRRGRAGSDALDGSGKQAQKAPSKKLAKLLGEDMSAIPVVSVPPPQGQQQQGGGPFNVGLPTQPETPWYMMDDYVPGEIIFDDKGAVKAGTLRALVVRLTSHSITDTPFFQAFLLTFRSFTDPTELFEHLADRYYLPTPESLVPEQYDEWKNKKKWYIQLRVVNALRQWLDKHFVREADEEILDKVEYLALKMPGEDTKAELMSKQLLQLVAKRRQGDPEQIFPGTSGSLLSPPAPLVPRVSGRPLRITDINPIEIARQLTIIEFAMFQKIKPSEFLSKVYQDEQKSMLLAPNIRKVIFTANVLAGWISMSILAHKDPRARGAVWKHWVQIGVECRNLNNFSSLAAITAGLNSAPIARLRRTREHVSQKVLATKADIDRNMDSSRNFSNYKDMLKTVNPPCVPFLGFYLTALVFIEDGNKSFIKPGAPTRGNAVPPSNSSSSISALASGQPPNANPTSEETVIPTKPLINFFKRSMSAEILRDIAQYQSQPYRLARSRVVQDFMNAEFERVHDAPDAWELSQELEPKEKDDERITRMLHDSVSGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z8</accession>
    <name>A0A1E3J8Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031941.1">
        <property type="nucleotide sequence ID" value="XM_019176028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z8"/>
    <dbReference type="GeneID" id="30193115"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="68193" checksum="DCEEAEBC66161AA5" modified="2017-01-18" version="1">MEQENPQPPLPPLKNPKYRHVSRSAAKRESVQLLGSIQDLRLQFSQVGVSHKAGAGAGVRSPSGLGSLGEDGEEEVGHPKLSAERGKERKERKPWKEVDLPQVDPKAARQEAQDIIRAIREIWGLSAPLSPTSPNLQTLSTSKSLYFDLSIVQGEEPAPRTSDDIHSALVTTARSIRRIRFLALSVSHHNQGQRTLTRGSLLPVPSSKLRPRFSTPSRPSLPLPRAVSGPVDRRSTSSTSLPGDDRLAELRKAALEVLNTLRVLEEGLRVGEAELQGPSLDQSIVYSEPDFLDSDYDSDSHNLNVLAQSQEMSLSSQPWEERIASEGREYRVLEGTEWEKVARDTREGVGKWVGVVEKLFIVGGKGENVGQEEGWSKEGWDGKVLERLHAFLLANLSLNLALRLPPPQSSDFATNFLSVLSDGYILIEAYNTSLIKSSKPWGFIPEEDVHATLNSGGSDESGTAAPTNEDVKRDKEWTFRRVGNLTCFAAALRHRFQLPIVMPSANTSTFLQPKRPMALPRPEKETKAIQTEQEPSLVACERATSAHRVSLPSALAGKGKDVPRIDFDPMVIAKKLEGWEGMLEGVAGKWVESVAKDVSDVRSAIQLRQAAAMQENKGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9F7</accession>
    <name>A0A1E3J9F7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032091.1">
        <property type="nucleotide sequence ID" value="XM_019176178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9F7"/>
    <dbReference type="GeneID" id="30193269"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="532" mass="57287" checksum="31715AAE2AF2AD08" modified="2017-01-18" version="1">MADGKSKSSPDLRDLSPEVRNASSDGDDDAVLAQLGYKSEFIREFGNLETFSFAMSIMGMTASIATTFTTPLSLGGVASVVWCWFAGSIMNISLGASIAELVSAYPTAGGVYTASSALCPRRWRPLVGWVTGYMNTLGQIAGVASTEWGLSGMILAAVVVCRDDYEIVNWHQFLLFIGLLAIHGILNSLPTASLARLTRGFVFINIGAAIVIVITLLACTPRSEMHPGSYVFTDVSNNSGWASNGLAVAMGLLSVQWTMTDYDAAAHISEEVHRAAIAAPVAIFVAVINTGAIGWILNIALCICAGDVAQLPGPSGNAFLGIMQLRMGTAGAMVLWSFTCLVATFTVQTALQANSRTVFAFSRDGALPDRGLFGIVNEKTKTPIYAVWLVVGISALMGCLSFASLTAVNAVFSMCAVAMDLSYIIPVICRRVFEGHPEVQFKPGPFYMGKWGYPVNIIMVLWTLFEVTILCFPETFPLTWDTFNYAAPITMAVMALSLVWYIAAGRKWYEGPRSNLEETETEQAFKPQPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JAU2</accession>
    <name>A0A1E3JAU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 45, member 1/2/4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031838.1">
        <property type="nucleotide sequence ID" value="XM_019175925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JAU2"/>
    <dbReference type="GeneID" id="30193012"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000700">
        <property type="entry name" value="Solute carrier family 45, member 1/2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="614" mass="68139" checksum="FA9AF0A2DD65279D" modified="2017-01-18" version="1" fragment="single">MSHPPPPEEQPSRPRQEYTSLSSILRKSKDNTLASDTHPVDQNGRRRSSTSGWLPNPSDRPDRRLENRSTSNDSRGTRKPSEDKGRLSTWGLMCLTISMGGSQIAWTVELGYGTPYLLSLGLSEQLTSLVWLAGPISGLIAQPLIGAISDSSHSRYRRRYWIVTSTVLLVFSGLGLAFTEPIAKSFVDLMGGGHGDWDPKTIKMVKNTAIGIAVLCFYCLDFALNALQASLRNIVLDITPGEQLATANAWHGRFSHVGNIVGFTMGFLKLNDMPIIRLAGGGQFRKVCIVALVLLIVTVWITCWTQEEKEKENIFGERRSNIRDAVATIYEAARHLPKAIRRVCIVQIAAFMGWFPYLFYSTTYVAEVMAKELQHHPDGDKATRAGSLALLIYSLVAIVAGTLLPYFAVRDRRLLKPMPDRLCDGDLPSDASEDNDDIEMARIREIVQQWKAEAARAGRPMRLPSMPFMLRNIWTAGLILFGCLMMSTFFITKVWQATIMIALVGICWAIACWVIIMEFLKELEDVSSQGQSLSTSHPQRPEHVRTTSNPIAFRSHPTSPTSRRPVNEYTPLVRSLSTADLEGAGDMQYTGEGPVAGGTIMGIHNLAIVFPQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBP4</accession>
    <name>A0A1E3JBP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032155.1">
        <property type="nucleotide sequence ID" value="XM_019175665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBP4"/>
    <dbReference type="GeneID" id="30192749"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="449" mass="48644" checksum="B7A1524521C903B7" modified="2017-01-18" version="1">MSTYDVPARPQNVGILGMEMYIPKRCISEDALEDFDGAAKGEDINSVALTVVSSLLKKYNVDPKSIGRLDVGTETLIDKSKSTKTLLMELFAPSGNTDIEGIDSKNACYGSTAALFNAVNWIQSESWDGRNAIVMCGDIAIYKEGSARPVGGMGACALLIGPDAPLVLEPVHGTYMANTWDFYKPDLSAEYPTVDGPWTIAAYLGALDNSYSTYVEKVAASKARAAKKAGVALNGDAKDEGISQFDYVCLHSPYGKLVQKGHARLHYNDYLRGVTSDAFANIPEDVKSQDKTKTYTDKVVEKAFIAAGASHYKSAVVPGSDCVARCGNMYTASLYGALSSVIANNPEGIEVGKRIGLYAFGSGCAASFFAIRVAGSTKNIAEKLNLKERLESMDVRPCQEYVDALMLREENHNAVKYSPQGSIDNIWPGAYYLEGVDDLYRRTYLQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBZ4</accession>
    <name>A0A1E3JBZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L37a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032224.1">
        <property type="nucleotide sequence ID" value="XM_019175734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBZ4"/>
    <dbReference type="GeneID" id="30192819"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="120" mass="13087" checksum="C5FC9BB50AEADE6B" modified="2017-01-18" version="1">MGGGEEVWEDLMEGELGWGLGFDHLPSPTTKRTKKVGVTGKYGTRYGASLRKTVKKMEITQHARYSCPNCGKVAVKRSNVGIWNCKGCNKAYAGGAYTFGTPSAATVRSTIRRLREVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC68</accession>
    <name>A0A1E3JC68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypoxia up-regulated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032311.1">
        <property type="nucleotide sequence ID" value="XM_019175821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC68"/>
    <dbReference type="GeneID" id="30192907"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130254" evidence="5">
        <location>
            <begin position="20"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="880" mass="95963" checksum="AD97CE5F525255D0" modified="2017-01-18" version="1">MRPQNLLSLLLLLAPAIQAAILAIDYGAEFTKLSLIKPGVPFDVVLDKDSKRKISSVVGWKRDERVFGAEAKMSATRFPDTHYPYVKPLLGKTALPPLSIWPNAPSSDGESIVFPHPSAPSYISPALPSPEAAWTPTALLAQQLSYYRHLAESLGTKKESINQVVVTVPAWWDHAQRRAYRDALELQGMSCLAMIGEGTGVALNYAMTRTFPDYNPATGEGEKEYHVIYDSGALSTTATVLAFYQTSEYLTPKSKTPINTTHIETLGTGWENVGGVLLDVAIQDILVEDFVKKSGKTGIKADKKALAKVAKEATRVKHILSANYEANTAIESLFDDTDYRSQISRASLEGALASTESLFSKPLTSALSTAGLSLSDINSFVLFGGNTRVPLVQTSLKSVLGNLEDRIAQNVNTDEAAVLGAAYYGAALSKQFKMKNIEVKESSVGDISINGGDVFFPEGTVLGEKKVLTLPAEGDINLEFSQSIAHPESSHGTSGPQPILSVQVYDIEKALKDFTAPSPVVNLTIRFDPKGHLSAANAVLVSNVTESKDGGVAGAIKGLFGGKEDDKQQVEEVASEGGKEEKKDGKKAPTKVALKFREKHLGVRPLSGEEKRTTNARLNSIAAFESAKASREEALNSLESYIYALQNHLSDYEPTALKDFSTPAEQTAIKDLVAKTFEWLNDVGDQATERELRTKYTALEILERPPVFRYNEYTARDDAVADFQKAMRLAASFFIEAKGNWTEAIEAARNATPEDPATPPKYTKEELGAVDDMLREYTKWIDELMPEQLKLDEDKTKDPVIKVRELEEKGKNLQATVMRLTNKKNPRKPKPTTSSSSASSSGTLDTQTDHGPSPTLSEKEAESTTESKPTDKEPLIHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEN5</accession>
    <name>A0A1E3JEN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032425.1">
        <property type="nucleotide sequence ID" value="XM_019175322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEN5"/>
    <dbReference type="GeneID" id="30192403"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17320" checksum="0820CC21BA19551F" modified="2017-01-18" version="1">MSTFDQNYFNSQQQAMSAPYFSAAAAGTEDHLTNSAVNEAGPSMGKSTKSGTKQSKKHRPLSELNEEEKRKRGESNRKSQRKLRKNEKDKIADLESRVQAAQTSLDDTQYEQAALRNALSDAQFENELLRMDQINEDALWDFEPHDQEQSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF42</accession>
    <name>A0A1E3JF42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032575.1">
        <property type="nucleotide sequence ID" value="XM_019175472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF42"/>
    <dbReference type="GeneID" id="30192555"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15372" checksum="C28F9DDE8F499DA4" modified="2017-01-18" version="1">MSTEEQQQGASCLPTELQPDKPTSSVFSRSEDAPVHNVPMRVINRPLPSELDENKVQAFMDEMKASCRGDAFTPIEVVKVKAPLKTDPTGPAQVFYFAMGGCHRYEATKRLQWETIRARIIEVPASQMRVYLGAGSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHH1</accession>
    <name>A0A1E3JHH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032633.1">
        <property type="nucleotide sequence ID" value="XM_019175530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHH1"/>
    <dbReference type="GeneID" id="30192613"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="295" mass="31511" checksum="94012648BB32A5C0" modified="2017-01-18" version="1">MTPTLQNNLTLDILAKAEAGGYGIVAQTVYDANMALALVRAAERSKSPAILQLFPITLAAGGGPFLQYCLTIAHNASVPISVHLDHATDPEHLELSIGLAEKGIKFDSIMVDASHAETDEENISIAVPYIKRCAAAGVATEVELGRLEGGEAGLRQIDGAMLTDPAKAEEFMKGTGAHILAPSYGNLHGSYKFIGGPQYDLSIVRDLQTRFKGRTPFLCAHGTDEIPDSLFQDLVKAGVSKFNINSWARDPYCETLGKELSSSSPFPEASEKAIEAYAKVCDHFFEVLGSKGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHP2</accession>
    <name>A0A1E3JHP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032518.1">
        <property type="nucleotide sequence ID" value="XM_019175415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHP2"/>
    <dbReference type="GeneID" id="30192496"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="103"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="37276" checksum="1B204817392EE9EE" modified="2017-01-18" version="1">MSADQENDPFVGQNGEEMEEDGDFLAPLLVAKLQEAGISAQDTKKLADAGFHTVEAVAFTPKKTLCTIKGISEQKADKILAEACKMVPMGFTTATEIHSRRSELVHITTGSTGLDTILGGGIETGAITELYGEFRTGKSQLCHTLAVTCQLPVTMGGGEGKCLYIDTEGTFRPVRMLAVAERYGLDGEEVLDNIAYARAYNADHQLQLLVQASAMMAESRFSLLIVDSATSLYRTDFSGRGELSARQMHLAKFLRTLMRLADEFGVAVVVTNQVVAQVDGGQFAVADAKKPIGGNIMAHASTTRLNLRKGRGTSRVCKIVDSPCLPEAEAIFAINPNGIGDPEELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI18</accession>
    <name>A0A1E3JI18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032638.1">
        <property type="nucleotide sequence ID" value="XM_019175535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI18"/>
    <dbReference type="GeneID" id="30192618"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26802" checksum="73B9F9632AA4776B" modified="2017-01-18" version="1">MAPKGGNAKKEGGRAKKAENEEKKQAAASKAKEAKEADEWKSGAKGSSKADAAAAKAAEAARKKAEKDALIAAEEASLPNKGKAAPKAGAKKKNNDKLTPTGLGVAGYAINDPLGLRKPKGVEEEETKELSAKGLDEMLDAMEIVNQKTDKAAVGAKAEIMIDAHPERRFKAAFEAYLEREMPILKDEHKGLRQNQMRDILYKQFQKSPDNPFNQAKIAYNATREEKVEAYKGMMESREAKLSRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI64</accession>
    <name>A0A1E3JI64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032766.1">
        <property type="nucleotide sequence ID" value="XM_019175034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI64"/>
    <dbReference type="GeneID" id="30192106"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="68856" checksum="2257ECB0CDEDF455" modified="2017-01-18" version="1">MDMDDDDAFLYGDEGATDTTAAQATKNEAADAQSKLSASMAASLAAYGIDASAAVVEPPLENPEDGGVEEEDDEGDDDDDDESDEEDVKFVFSGNPRALDLRKQQQPVNVVGIGKWAHASTGAQAPAPATPHNPSLIADASTRYHTTEYTPAARPSATPQVNPLQNPPLAPNNTAPNLQPQQEPTPSAQPQMTQTQNGPPINPNLPPSTLPVVTAPTTQGFKPNPSNPSGIIPSTGQSVYDIEAAMFEGSGQPWRMPGAVVSDYFNFGFDEVTYPRYLRYRSEMEQGVKALANLPPMAAMGGDLAQMLHLGNGINLPQMMQMGQMNGMNGGMNMPGMQGMNGGMQQMQQMQQMQQMQQMMAMGGMDMGMMQQGQGQGQAQAQAQQARPSQVLLLKLKRNPHLRKNPSKRKANMQVETSRRPAPPTRPRAGPVSGNVPLGPRAAAVPSGPANAPTGPSSSNPTLHAPTGPKSRFRDFKDKDRVDISGAGSLDYGDEEEDRYGKDDREKEKDKTRDWDSGKERSESRGSRRRERSPRSRTREREKGGYEEYEEGGYSSSEDRERRKRREKEREKEKSEKKERRRKEEDVSLGAEGWEEEEGEERRGASSRRKRSDSEDEDRHRRSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JID8</accession>
    <name>A0A1E3JID8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032775.1">
        <property type="nucleotide sequence ID" value="XM_019175043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JID8"/>
    <dbReference type="GeneID" id="30192116"/>
    <dbReference type="OrthoDB" id="10333483at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="437" mass="49294" checksum="4ED46226DD56FDD7" modified="2017-01-18" version="1">MSMASYSTTTPSQEAQLGGAITQSRLSSEAWIEKSTPTSDDHGYYRTAGGLDCMLQEQENSTTGFYQQAVQSVGPCRSRVLSAATFLPVRGIVERATVTALAPCDVYAEEDKEEMEKANKINTDVRHALQSSAPVWLAECRTRQSAEPLKEAEARIFEEFSKKEEYHGVALEHLDPTSANFSGYWHPLSELLDRSEVAPEDMTQKEWHQLMLMRTPLSKKSETAGNKDDTNTSLYDAEDAQDGDNGFWVGERPTTARSWEDQEADPLRAQPIGSLYRGTDASLEMSTVPLTALFHETFTTVSKEDDAERKTEAVQRANGMMSDINEILQETEHEWYPQVLQSRDLGAFNTQEQQAYERLSGLEQYEGVGFVKVPLDTARAVSRIKPDHIGDEEWEIYLREWDAARGSSRQQEEGGETTLSRRSRFSRKLRTFFRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIH4</accession>
    <name>A0A1E3JIH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02956</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032827.1">
        <property type="nucleotide sequence ID" value="XM_019175095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIH4"/>
    <dbReference type="GeneID" id="30192169"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130384" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="54"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO00635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="673" mass="76491" checksum="ACC47C6393939285" modified="2017-01-18" version="1">MRSTLLAGLLALTLSALHAEAAPSLEQKPLGAKESSLQGAVQDKAMKKRSLKGRFLHITDIHPDPHYQFKATVASGCHQREKKKKKKGKKGKGKEVEEQEEQDYDVSIVDKEDLAGKYGTANSVCDCPLSLVNVTFDWLKKEWADEIDFVVWTGDNARHDIDRNRPRTPNEIFNLNHMIVGKMLDTFGKDMPIVPSIGNNDIYPHNVLSAGPSRITSEFLSIWKRFIPPEASHVFERGAYFSSEVIPDKLAVISLNTLFWYDSNTLVDGCGDHSNDPGALEMDWLEVQLSNFRQRGMQVWMTGHVPPHMGHYYDNCYLRYGDLALRYQDTIVGHLFGHMNIDHFFFIDVDELEATSNLLPLSPSNASIQSYGPYLPNSYSPSGRYTIQGRSGAKSLEQELKKDFGEMPGPRVLKLKDYAVMNVAPSVIPTYYPGIRVFSYNITGAEDDFRGLYEPTDKQEEDEEELGEEEGDDTTDTLFSDSREEEDSSLLSTLKRKGGHRHKKTKDDCSLPENEDKPHCTFKHKPRHYSKHSPSRKNGPLSPLGFVQFYLPDLSKKSVKKGKKEPEWKVEYTTYKVKDLVPKGNLTQPVPVPFHLLPSYDPAVFQRPKNKAEHKEVAKKKDKFNKALKKVTPYRMKDLTVGSWIKLARMLVLEKKRWSKFAELMLVSTEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIQ1</accession>
    <name>A0A1E3JIQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032718.1">
        <property type="nucleotide sequence ID" value="XM_019174986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIQ1"/>
    <dbReference type="GeneID" id="30192058"/>
    <dbReference type="OrthoDB" id="2578240at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="12803" checksum="894078951E781ED1" modified="2017-01-18" version="1">MATTSTSTSGSGFHNAMAKVPVLTGKENFPKWKTSLTLYLGSLGACAFIQKDKSQMDDEAWRARDEQIAYSILLTTSSPIQQSLFHLLEEASATSPPSWHVLPSISLPLSKTDCASAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JL60</accession>
    <name>A0A1E3JL60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032864.1">
        <property type="nucleotide sequence ID" value="XM_019175132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JL60"/>
    <dbReference type="GeneID" id="30192209"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="204" mass="23431" checksum="38E18652C9117008" modified="2017-01-18" version="1">MGRRTTRQEPESPPGGYRSVAPDDPDAYPLLVAFDLDYTLWDLWIDTHVVPPLKRKGDVINQLVDRRGQDLSFYREVPSILADLKHRRIHVAAASRTSAPELAREALSLLLVPAPEGNSHVKALSYFNTLEIYPGSKLRHFRELHRKTGIPYDQMLFFDDEHRNFEVESLGVTMQLVPSSGTDKKLFRQGLAQWRKRRGIRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM43</accession>
    <name>A0A1E3JM43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_02671</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033193.1">
        <property type="nucleotide sequence ID" value="XM_019174814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM43"/>
    <dbReference type="GeneID" id="30191884"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="17">
        <location>
            <begin position="165"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="328" mass="37993" checksum="0C7B261E585441CD" modified="2017-01-18" version="1">MVITSFADKSGSFNRQVSSFRDVIEPGGKFGPEKGRYHLYVSLACPWAHRTLIVRKLKGLEDYFEADVSVVHPHMLEKGWQFVPKDLADAKPAPASEHNNETFPNATVDHLYGSSHIRDLYFKADPEYSARFTVPIIWDKREKTIVSNESSEIIRFLNTAFNAALPKDKAEIDIYPEELKKEIDELNEWVYNDINNGVYKSGFATTQEAYEKAVKPLASSLDRVEKILSDGREFLIGGKLTEADIRLFTTIIRYDPVYYVHFKCNFGSIRHDYPYLHKWLQKLYWNSPAFKDTTDFDHIKEHYYYSHININPNRIVPFGPNVDIEPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMG1</accession>
    <name>A0A1E3JMG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033300.1">
        <property type="nucleotide sequence ID" value="XM_019174921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMG1"/>
    <dbReference type="GeneID" id="30191992"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="177"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="308" mass="34421" checksum="0DA22ADCD5CF1162" modified="2017-01-18" version="1">MSISRQVAKTVFAHEVSEGAGARVRRSIGTKELRNLTPFLMLDHFTIHPGAGFPDHPHRGMQTLTWLFRGIFNHEDFLGNKGELRAGDVQWMTAGEGIVHSEIPWFDPDPKKREPVEGLQLWIDLPSKLKYIKPEYYDRKSADIPVATPVEGVKATVLSGESHGTKGTVTPAGGAWYIDFKLERPGVSVFQPLPEGYQAFIYLVKGKLQIGEDKEQYDKFNLLVLSTEDGQSGVRLTRPADAGDEDVHAVLVAGKPLDQPIVQYGPFVVNTQQEARQAIFDFQTGSNGFERAPGWKSDIAKEFDRQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP96</accession>
    <name>A0A1E3JP96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033209.1">
        <property type="nucleotide sequence ID" value="XM_019174830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP96"/>
    <dbReference type="GeneID" id="30191901"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO01957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="362" mass="39486" checksum="0ECABD683DFEAC66" modified="2017-01-18" version="1">MPHTRRRTPALRASPYDRQEEKPPKQPRKTRKDVCKICKTTKTVLWRSNPDDDLKGPKTHLCNACGLWRAERGRHKTDAELARSKAKKKNTQTPAVATASPDPSFSSDEKYPVRVVATPKAPVRDGVKETSLAASSSPVLQPIQKPESSPIPYTLEINSRVVSSTSPALSAASDLSVEGPDTGGDDEDGPVEPDVIQGALSLLNLGRRMNPKDLLMIVNSTLGSRSQLASTTRSIFLHILKSDPNPQLPQLPIRSQSSSIFALRANDSSMAYPDPFFKPQYSPAASFPPSVSAPRKDRDSRDSRLSVFGRVRGQDRVPRSLSHMPFHRSAASARPGSSDMGIAPVSSASWGPVLGRGKRLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPE5</accession>
    <name>A0A1E3JPE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit M2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033259.1">
        <property type="nucleotide sequence ID" value="XM_019174880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPE5"/>
    <dbReference type="GeneID" id="30191951"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="50442" checksum="8DB5AD9BD9C5B533" modified="2017-01-18" version="1">MPPEDIYSGSPYRCHSSASSSSSSSRCSAGSSSNTDEHMPHINAIRPTYDYGCGAVSDEADDDQGVTEVYCNLVITEPMRPPPREKTAEKKKQVESVKEVEVARRFPEEEEEEILKESNSRFVLFPIRYNEIWHAYKSAQASFWTAEELDLGHDLHDWHGKMTENERFFILRILAFFAASDGIVSENIISQFAMDVQIAEARAFYAFQAMIEQVHSETYSLLIETYVRDAEEKDFLFRGMENIPCIKKKADWALRYITEELPFRTRLVAFACVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGMHTDFACLLYNHLTHRCGQDEVHRIVQEAVAIEKEFLTDSLPCALIGINSGLMCQYMEFVADRLVVDLGYPKIYNATNPFDWMELISLQGKANFFESRVSAYQKANVSRSATPSGQKGKGGESVSRRVFNTEADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPK8</accession>
    <name>A0A1E3JPK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033329.1">
        <property type="nucleotide sequence ID" value="XM_019174950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPK8"/>
    <dbReference type="GeneID" id="30192021"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="466" mass="52112" checksum="42A6D39AA6B34DE6" modified="2017-01-18" version="1">MLSPANVRHPLRWAVHAQRYAAPATACPCGCAQFHPGLSTRRPLATSAAPVAPRLPRVPWGFRRYATEAKGGWATETEQEQAKMFEAAKVKVDLYKKTMEEEANAMEIDIKAQIERARIQKELAPLSEVWDKYLELRKAIADDQQSIIDMKVFLDDPDPSVKEMFEAEHETLCTELDDLLTSTFPSVILPPPSTSSLPVVMSLNAGVGGLESALCTEDLARMYVRFAQTRGWKVEEISRVDGTGGKGGGGIREMTVKFDAPAYGGGDVEIYGALQWEKGVHRIQRVPANETQGRIHTSTVAVIVLPIYPDTAEAPLVDPKDVRTDVMRASGAGGQHVNKTESAVRMTHVPTGITVSMQDSRSQHQNRAWAWEILKARLSEKKHNEEVEMKRASRRDQVKGADRSDKIRTYNFNQASHPYHRFGFTIIGLQNILDGEGMEEVIMKMKDDFRERRLEALLKGEEDLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPU0</accession>
    <name>A0A1E3JPU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033174.1">
        <property type="nucleotide sequence ID" value="XM_019174795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPU0"/>
    <dbReference type="GeneID" id="30191865"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119">
        <property type="entry name" value="ABC TRANSPORT PROTEIN ATP-BINDING COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="241" mass="26434" checksum="D419EDE26251F6DF" modified="2017-01-18" version="1">MPSPILSVRDLTVTRDSGGPILHNLSLDIAPGEVVVVRGPSGSGKSTLLKCIAELNLYQQGTITLDDKTSKEWGVPKWRIKVAYVPQRPSILPGTPLQLLETIRGFAARKESAREMKKFEIEKMDPLDLAEKWGIAKTMWTRDWETLSGGEAQRIALAVSVGIGGADVLLLDEPTSALDEESSRKVEDSLIGMLPPPHSGQPSEGVHRYDTGLKALVWITHSAEQSERVATRTFDVSPFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRN2</accession>
    <name>A0A1E3JRN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033590.1">
        <property type="nucleotide sequence ID" value="XM_019174538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRN2"/>
    <dbReference type="GeneID" id="30191600"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="36956" checksum="AA7B4396F1DF2D53" modified="2017-01-18" version="1">MGPAFGYRWIFDRRVYTIDVTVGDGSVTLPILVDSGSADIWVAGSNCDNCTSSGMADSGLTATDNCQEQEKGYGSGSVKGCLVPTDVKFGDGYELEAFPVLVASDSEGFDRSYMSGIFGLAMNKSSINNQATPLNMMSQLGMISTPEVGFYLDRAETGSEIIFGSPHDDNHADQSKKVTLPKVTEDDGLYRVTMDGFVSHGYMVSSTESNVSMENIEVILDTGTSDIRVPDTMMLPIYAALGNGTFFTDTTTGDLVVPCEGPDNKDEALALQFGGQQFYFKWEDLVANPSSTDANYCYCRVQASPSSISDYLIVGSAFFHNVYHVINIDSGYTTLYGLADVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRP7</accession>
    <name>A0A1E3JRP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033566.1">
        <property type="nucleotide sequence ID" value="XM_019174514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRP7"/>
    <dbReference type="GeneID" id="30191575"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO03515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="758" mass="84584" checksum="F554A755A2C3D1A6" modified="2017-01-18" version="1">MEHDAQINSQIPPKGPAVVTAVAAYNADLPNGNASILETTGHAVGVKAMVSIANIQLLLVEGESEKYPQERMRREIRPNSSGVARSSSSDAGPISYRSPFVIRYPIAPSHNTSVLVSDDENEAESPLPGFPNHPSNGRPWGKSGDGAKGASDIRYSHFMPDEAISPSADSPIKSAHGLAQEKLIQRLRSECPDPLMAGIMTEEVCAELFEFYFRHLNATVALLDSVLHTPDRCRNRSPLLFTAVLAISSRVIRPKLYSQSLLLANRMVGQAVEFGVCTLEVIQALCLLTHWKKADDDTSWVRVGMAIRMAQMLGLDKTSPRPLPRDEMRAREVLNRERVWLSDLSIAHGLPKMLKDDVEDPADWVADHPHLPTPGESSFSPIITFNRLCKLYTDSLESMNGDPSNMRMLNWMEIEWKRWRERWLLKNDRHNFSHFQIAALKVSDAIFRFHLGEYRLLFIARFETKGKPLKVSEPSPLSMAFTECSDAALGLAEIVQREFVPHGYLTYCFSTTWSMLAITVIWLVRNLEPMSGTDRARVIRLLADLQFSMGEASTSGDDMAAYTHRFLKHLLNGISPEWQLASFMTQPSPPSYEGHDRSDRFQRAGHRSSFDQLPPPPHQQVPNGRSVHLPQLSNNQQPQYAPPLAMPSSLPGVEQPSFPVDQPFVWAPSSAQELIQEYLWSTPQLPLQNSHAGNNIAGPSVNQQQVSQQVPPVTEGQAMTMNGTGMYGALPINGDYMDLFPETDDDLWKHLFPSSVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRW4</accession>
    <name>A0A1E3JRW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Insulysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_02443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033645.1">
        <property type="nucleotide sequence ID" value="XM_019174593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRW4"/>
    <dbReference type="GeneID" id="30191656"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="397"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="790"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120200" checksum="355E7DE6108B2FFD" modified="2017-01-18" version="1">MASPFPPCPPIPKASGPVSLIVPPTEDRAHKYLTLDNGLEVIVVSDPKADKAAASMDVGVGHLSDPEDLPGCAHFCEHLLFMGTKTHPQENAYSQYLSSNNGSSNAWTAMTSTNYFFDVSPDALEGALERFAGFFVEPLFNEDCTEREIKAVDSEHKKNLQNDVWRFYQLEKSLAKPGHPYGKFGTGNYESLWSIPKEAGRDPRRQLIEWWEKEYCARRMKFVVAGKEDVETLAKWVKEKFAGIPVRTEGKPEVGRDGQRVVFEDSPFGPEQLQNFTFAKPVRDIRGLEMVFPFPDTEHLYESRPTHFLAHFLGHEGRGSVLSYLKKQGWVNTLRAGDYHDASGFSLFKVAVDLTPEGLQHYDDVAKAIFKYISLLRSQPPSRLAFDEIKAIADISFRFAEQGKTSHYCTNLSSWLQSPVPREKIVSSKWLVEEYKEDELSSALQLLDPRRANIGVTCKELPKSVQGSFDQKEEIYGTEYKRVKFSEEFLRETTAGAPIPELALPGPNLFIPKKFDVEKFEVAEPAKRPAILRDTPLSRLWYKRDDRFWLPKANLEIMLHSPILNVTPRNAVLSRLFCDLFSDAITEDVYDADLAELSFGLWNTSQWISISAGGFSDKLAVLTETMLDKFVNFQVDPKRFEEIQEATRLYWKNFALSDPYKIGRFWDSYATHEVMWTQEEKLRELEYITVADVQAFGKEMSARLHIETLVHGNTSPEGAKEIQDMLERVLSPRQLTATELKATRSLVLPASTEHVWEIPVPNKSEVNGAVIYQCHVGDPSDVTLRNHLSLFSQIASEPCFDTLRTKQQLGYIVSGHASQSSGAMGYSVLVQSERDPIFVETRIEAFLDGLKETLEGMSDEEFEKHRQSLIAKKEERPKNLNEESTRFWGRISDRYYEFARRENDVAVLKKATKQDVLNVLLNYIHTSSSTRAKLSIHLRSQYKGVKFDIAAAAPLVEAFTKAGIAVDPAAIQTLLTNNPTLQQVKDFGVAAIEGAANVAEEVKGQLKSVVDALKGSEEATEEQTEEVKLRPGNVYIENIEEFKARLVPSKAAVPVEPLRQLVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTI8</accession>
    <name>A0A1E3JTI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033488.1">
        <property type="nucleotide sequence ID" value="XM_019174436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTI8"/>
    <dbReference type="GeneID" id="30191497"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="465" mass="49922" checksum="D8518FB6199AAED7" modified="2017-01-18" version="1">MPTTILLPRQNPAPHLTPLPVLLEAQRIARSRGHILDIQALMSPAQREDYRASIGLPGRDRDEDEEDEEHEEIEKEEKAENGKEAEHVDGHEATATDTPAPTDPASATASPAPAARKPFKVPDLSHLHWKQRQKRLAHIAREQELLARGQITEMSIFTEDGVPQPKTRTKEKLLTNTEKEAIRDSASYWQVPFSWHIILADLLCRNNLLMQARRQRIPQWDYSTQQQHFERHSQDYYTQGLSPPPTPLHKKRKLSSTDAERALPNGTSIERSLSNEGGASDTPGSASNHMQGSGRHPSATPTSSYTPLQRGTTPGSHPGQPSSARSNSLSLPPGFSGHTAPSGGMNPSLMAGMNPSQMGARPDGYSQGVNGLAMRGMGSLPHTGGAPHNPSNPPATPGSAQGVPSFLGLNNMGAMQGMQAAQALQAQGRLPPSMSGMPGLSGMPGLGGGGQGAQGPMLSGGWRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWW8</accession>
    <name>A0A1E3JWW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L198_02048</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034010.1">
        <property type="nucleotide sequence ID" value="XM_019174203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWW8"/>
    <dbReference type="GeneID" id="30191261"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="23" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="50"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="500"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODO05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="634" mass="69509" checksum="65AA2AC1B59FECE1" modified="2017-01-18" version="1">MLALARARAVSRPLNRLARGYVAASQTHRAAEAPNFGQKKGYPIIDHEFDAVVVGAGGAGLRAAFGLAEGGLKTACITKLFPTRSHTVAAQGGVNAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPNTVVELEHYGVPFSRTKEGKIYQRAFGGQSLQFGKGGQAYRCAAAADRTGHAILHTLYGQSLRHNTNFFIEYFAVDLLMQDGECVGVLAINMEDGTLHRFRSHKTVLATGGYGRAYFSCTSAHTCSGDGNAMVVRAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSEGERFMERYAPTAKDLASRDVVSRSMTLEIREGRGVGPEKDHIYLQLSHLPSEILHERLPGISETAAIFAGVDVTKEPIPVLPTVHYNMGGIPTKYTGEVLTVDEQGKDKVVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACANHIRETLTPNTPHKPMNPELGKESIDNLDKIRNASGPLPTSQIRLNMQKTMQTEAAVFRQSLDAGVAQMKEVYKSYDQVGIKDRSMIWNSDLIETLELRNIQQCAMQTVVSAAARKESRGAHAREDYPDRDDESWMKHTLSFQRDPESPEVELQYRGVIDTTLDTNECKPVPPFKRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWX8</accession>
    <name>A0A1E3JWX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein, X-linked 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034019.1">
        <property type="nucleotide sequence ID" value="XM_019174212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWX8"/>
    <dbReference type="GeneID" id="30191270"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000609">
        <property type="entry name" value="U2 snRNP component IST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="38647" checksum="E70A7369A1C720A9" modified="2017-01-18" version="1">MNTVKEINRINERELELGVKGSWHDEYKDSAYVYIGGLAFELTEGDVITIFSQFGEIMDCNLIRDKETGKSRGFCFLMYEDQRSTVLAVDNMNGAQVVGRTLRVDHTKNYKQPGKRNEEGEYEEPEGPVYNAMPPILSDSDDSSEEEEGQDSLDEEDPMAAFIRAEKKAQQALKGKGKDRKKRKHEGESKEERRARKEAKRAKKEGKGKGSGHKERGDERENKKGGREERGGKREDDGFWSKGAAGDDWRQGRWELEREERNGGSRARGDEPPSRSHGHEREKDERDRRPERDERDRRDERERDRRHGRDDGHRRDDRDRYRDERRYDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX24</accession>
    <name>A0A1E3JX24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034008.1">
        <property type="nucleotide sequence ID" value="XM_019174201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX24"/>
    <dbReference type="GeneID" id="30191259"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130630" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="18712" checksum="0F58E48C996A8805" modified="2017-01-18" version="1">MFFSHASVLPALLLAVLPALAVPASAVSDVPSATLGSTNAVTAGGPGSSSSVASTPQVTPAFWVDIEEFAKLHSDDKNEGSGDGQKRPYGITGPNAVKFKFNGDVYKEETFKISYYKSSSWAMPSGTYNPEAWTTASGTPTKVIECVATANASLTENAWLVPTPDISTTTGGVGIKCTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX81</accession>
    <name>A0A1E3JX81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034021.1">
        <property type="nucleotide sequence ID" value="XM_019174214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX81"/>
    <dbReference type="GeneID" id="30191272"/>
    <dbReference type="OrthoDB" id="2576600at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130661" evidence="2">
        <location>
            <begin position="20"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="990" mass="98852" checksum="9778704A1D82A0A5" modified="2017-01-18" version="1">MKIQHGALLLPLIASSAVALPSRRHRPLFRKVYGKRQDAVDTGVNATESASGSSSSTVTESATVTSYVTASASGSGSSNASSSYTESSSYSAAYPSASSNSTDPDYSLSNSTSSYTSSNSTDYSNSTQTLNSTLPSSNSTNNNSGYDTQLSSPNNISSEAISALLNNTGSYATYTYSVYSPETVTQTSTETEVVTATSTDSGSASASATAASYADDGSDDDGDEDDGNDDDGDDGDDGETSNETDAESYWDQIEAAAESYADAYSGTAMPTKTLDVVLEPTQEADGSWEYIIRIGTDGTATAFPTWSASATASSSASSGSSSGSSSDADSQYASAPITTSADITGATATTSSYSNPYLQSATSVYVPAAAATATSSSTDSSSSSDYSSDEDSSDEDSSSSSAGVSSSSDDEDTTSSSADESANNSADDSSPSATSSTPSAASATASSSPYMVPGHSSSSYGDSSSSDDTSSSASASSSSSASAASASATTDPNAVPGHSSSSYHDSSSDDSEDQSSDDSEDSSDDTSVSASSEGTPSSTASYESESTASASSAPFPPWYGGSSSDDEGSSWSNETVTNSSTPWANETTPYDNSTYPGSDYTTPLNGTNTTVPLNESIPINSTYGNSSVNSSVPSLEGGNGTSSSLDSWIATATESGDGLVTVAPTETATVAATLTLANGTVVQPTASSNESVSASEEEASATESGSVAGSMTVSQPSSGASATESEASSSESAIEGIASPSAFSSSVDPTITASSTQASNTTLSPTSSDSVSVAENEDGIETDYVTAWTTIDYTQTLSASSSVIPTASASGVANVSDSESTASVSSSSEVSDSEGSTPTASVTNATASASSAEASATASFAEGFAVGLGDASSFETESQSATESASSASSVETQSASTAYNETIPTSYSSYSASEGTGSISASSASVTESASSSEASVTASATESASELEETACASESAGLEERAVDDDEEYEEVWVNEDEIEEGWEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYV2</accession>
    <name>A0A1E3JYV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033727.1">
        <property type="nucleotide sequence ID" value="XM_019173920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYV2"/>
    <dbReference type="GeneID" id="30190972"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="473" mass="50126" checksum="D862FF1C9433D97C" modified="2017-01-18" version="1">MPHHFATRAIHVGSNPDPATGAVVPTLSVATTFKQDGINKLRGFDYSRSGNPTRAALEELLTSLETAPASKTSPDARQDASGGDSFVFSSGSAATAAVGIWASLSKAEGGAGGADGNGGGGHVLAVNDYGGTARFFSRAAGPTKLEVTYLDMIEAGEAGIRAAIRPDTRLVWLEVPTNPTLLIHPLPLVSRIVKSLPAETRPLIIVDTTFLSAFNFTPLVADSPDEEPLADIAYSSLSKYASGHSDIILGSVTVSPQTAMIRPELIKSLRFIQNSFGACPSPHDCHLLIRSLKTLDARMIKHGLNALRIASYLSKHPQVDSVKYPGFKEDIGFADIQKLLSASLKRQLEFLGWSLPWSDPSEKQVEGLNPDSLAYVRTLGIPFGGVVTFTLKNGSLETAETFCTSLKIVTLAESLGGVESLIEVPSGMTHASLPQATLDKLGITPSLVRFSVGIEDYDDLVEDLEAAFAAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ49</accession>
    <name>A0A1E3JZ49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034135.1">
        <property type="nucleotide sequence ID" value="XM_019173430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ49"/>
    <dbReference type="GeneID" id="30190477"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="488" mass="52016" checksum="CA1FE1DAF0EB7D3F" modified="2017-01-18" version="1">MPDQHMQDDQDVQINTQPTLTPAGEELDHAQTGHTEAPCPEDLQRGVWHSFGFQPRDPDTQNTLDGQQDAYLPSPLPSAAANQPTLPTTITNTEEIEMCAPPPTFEASPREGERTVLGGPGPSHTSSDRALTQQGHAAEGEEKQTESSVGPDRSSRGRGKRGRGRPRSNDIIRYPRPPRSSPRLAECAQGLQLQLGSAPTLEGGEDSPLATVTRTSPRQQTHLDVPPHHAGEGTNARYHPYSQPSTPFTSSFPSTSTPSRSARSKAPKTPTPNTPSTPSLSHTNSPTTPITPTSLARRRGLNQGYCLEEAKGLKDEVSPMKGSGWPGWGPLGSGGRRRRMGMSMGMGTGVGMGSSPGMRMTSMDFGAAIPRRPPSMTTSELPPLNPAADSPSRGGNVGDVGALVGGQEKAMEGPEDSEMGEEDTAPAPPTFIENPFLSQNTAQSVEYPPSPRSRAIKYGDEEEKEDGEDGGSCTMLSELHLKEDDSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZD9</accession>
    <name>A0A1E3JZD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034243.1">
        <property type="nucleotide sequence ID" value="XM_019173538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZD9"/>
    <dbReference type="GeneID" id="30190588"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="198" mass="22575" checksum="8286C72D1FBA9E62" modified="2017-01-18" version="1">MAARRAYSSLPAPHTGAGPSLNARFIPAADLPKPLFRRIASQLAHLRSQGKDPATVSIPNPFLLHRARQRQDVSALTGLERFYWRKPQFSARRQKLLLQQYDPSILPPSPLNPTAEPRPIQWEDGTVINWQGEVLEKAAKQSPYDGRKVMFKGHIDERNKPQKVADRQERMKGMDKRIAAWRKSKADDKIRARPSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZF1</accession>
    <name>A0A1E3JZF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033937.1">
        <property type="nucleotide sequence ID" value="XM_019174130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZF1"/>
    <dbReference type="GeneID" id="30191187"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="30"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="36956" checksum="6889A7F9AD56F7CE" modified="2017-01-18" version="1">MSMLRTVKPKNARVKRALEKREPQVIENEKTAIFVRGQATSDMVRNTMKELYALKRPQAINFSRKNDIHPFEDPASLEFFAGKNDASLFVTGMHSKKRPNNLVFTRMFDGRVLDMIELGVDGFKSMDDFPTLKSSLGVRPMMVFHSDLFDTHPTYQHLKSQFLDFYNGHPVSEAPLLTTLEHVISITAGPVSDETPLPKVHFRVYTTKLLASGTKVPRIQLTEMGPSIDFCVRRVQEADEEMMKHAMKRPKLAKTDIEKGLGKKRKNIETDEMGDKVGKIHLGKQDLESLQSRKMKGLKVHKEKKTKEAKEAKAAAREAEAMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZM6</accession>
    <name>A0A1E3JZM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="2 10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="2 10"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034017.1">
        <property type="nucleotide sequence ID" value="XM_019174210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZM6"/>
    <dbReference type="GeneID" id="30191268"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000087">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="244"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="67865" checksum="D3C442A01EF967D0" modified="2017-01-18" version="1">MSAPNDAPAAAAEANKLHKDEVTGEMVSKSELKKRQKERQTAAKKAEKAAARPAPVQKEKKEEEPELDATAFYDMRTKEILKLRETKQPNPYPHKFHVTSGGVRKFVEDWSQEGKVEKGETLIRLQINLSGRVYTIRESGSKLKFYDIRQDGQKVQILAQAQNAPSLEEFAAAHAVIRRGDIIGVTGFPSRTKMGELSLSISAIQLLSPCLHLLPGREGLVDVETRYRKRYLDLIMNQSTRDIFTTRSKVINHIRSYLIDRDFLEVETPMMSMIAGGATAKPFVTHHNDLKLDLFMRIAPELYLKELVVGGLDRVFEIGRVFRNEQIDMTHNPEFSICEFYMAYADMYDLMDMTEELIETLVKKVTGGSTKVTFHPEGRGEGKKSYDVDFARPWKRFDMIGELEKQLNVTFPPGDTLHDDNANKFLRDLCAKNNVKCSEPQTNARLLDKLVGEYIENQCVNPSFIVGHPQVMSPLAKYHRSRPGLCERFEAFVCTKEICNAYTELNDPFDQRERFEEQVRQKDQGDEEAQGVDETFLDALEYGLPPTGGWGLGIDRLVMFLSDCSNIKEVLLFPAMRPVVANSVEAVAPSVTATEAAKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZR6</accession>
    <name>A0A1E3JZR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034047.1">
        <property type="nucleotide sequence ID" value="XM_019174240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZR6"/>
    <dbReference type="GeneID" id="30191298"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16324" checksum="E0159B002EA8B218" modified="2017-01-18" version="1">MAKEDQPHHEPTEPSAISDAAQHSTMSGSEQSRARHSRKVAFVTDEGEEDEYEQEDPDARSRRREKLKAAATKYPTSQEERQSELTQLTDEQAPTAEGEPSAASARGDEEWVDGQKMLRSDIDLIEVVWIFDVETRGVVRPTCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K088</accession>
    <name>A0A1E3K088_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034579.1">
        <property type="nucleotide sequence ID" value="XM_019173874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K088"/>
    <dbReference type="GeneID" id="30190924"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56380" checksum="F0303AFF6FDE9848" modified="2017-01-18" version="1">MSTLEAPHESTKPSKWGKVRSSVKFTAAAKEKNRATKADSLSVSNAPMQSSAGAAAARSLVLFFGFLFRRPSKLFKPNRGKQTVDTWLGLRQLAISTDQHLSPAFIRSLLQNRTGLIAVGLTILPPMLVNATLGFLLFTSHSLFSLGLAKLDWFQRKVEVENEKGEMIVEEQEEELNLETLIRGPSVIPNHPTVLSAVAGAGAGLIQGMAFTPVDNVVRLIHQSTTSWVNILARFVHLPVPKTPDNMKGSSVTPVQAIKNFFSDDAWRRNRNWWIGWRWAVSRDALSYSCFFATFDVTRRVGLRVKGMFGGNIEHDWDNIFILDFDGNAHDDSISSPSPPPSNNTSSSLPTYRPTGDQPQAPTLARVAQAATIVTGGVLASLLAQAAGRPFRECQRIMQLDDREWARRAAKGEMMARRPHFWQALLKPRPGARPHPILNTLQTKGLRPFIRSEGEFKSAQMKRELAQEAQAQGKLRGMVGTVVKRVGWRVASVGPWGCGFLVWAWIGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0C1</accession>
    <name>A0A1E3K0C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_01703</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034571.1">
        <property type="nucleotide sequence ID" value="XM_019173866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0C1"/>
    <dbReference type="GeneID" id="30190916"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO06471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="14908" checksum="03D00B5666EDB359" modified="2017-01-18" version="1">MSSKTGGGKGGKSKTSGEVKVLTTRSSKAGLQFPVGRIHRFLRSKNANNVRIGAKAAVYVASIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDMLIRATIAGGGVLPHIHKSLVAKPVGQQLKKSKSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1J3</accession>
    <name>A0A1E3K1J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034417.1">
        <property type="nucleotide sequence ID" value="XM_019173712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1J3"/>
    <dbReference type="GeneID" id="30190762"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000309">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130711" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="318" mass="35764" checksum="1807E2E4261CFA64" modified="2017-01-18" version="1">MLKLLFPLLLATTALAHGDHSFDLADDADHALSYAERHMHTEHHIDSFDLESFFKLHDLDMDGFWDVPEIQAVYGLRHHSIKEKIGKVEMVDERAKNIVRRVLEALDKDEDGKISLLEFMLGGTGGLPSFDGYKDLGHHYDEESEYFLHHEELYHSTPETQTDDSYSHPEDIQHFRHHAEIEDEEDSRERKFEGLGNDANLEKDHVAADPLDHHAHAAGEGPPADDIPPLAEGEENLKPGDEVEHSAPKPIVPKRVDPGAAPQRILDGGKVGDLEGLKEVAAGQPGYGGGRPRTPEERLRSGVPYKYKMKKGLRYDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1W9</accession>
    <name>A0A1E3K1W9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034631.1">
        <property type="nucleotide sequence ID" value="XM_019172905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1W9"/>
    <dbReference type="GeneID" id="30189946"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="343" mass="35146" checksum="1E65AFDB32ACF509" modified="2017-01-18" version="1">MFTPIETLLGGVFLHLATSQFLTDTGRVFGISSIVDGAVLGQHEGWRLAATGGLVVGPLVGALTGLTEVYPGHALLAVQAIDVRRIAVAGVLVGLGSRLGSGCTSGHMLCGVSRLSPRSLVSTAIFFSTAVLVANLFPSSPVPSLPTYALNIPSVATIAAIASSTVAAKLLYKAITSWTFSTATDAPSAISRLAPYFLAGLTFSLGLSISGMTDPSKVAGFLRFPTPFAFDPSLVMVMVGGVLPNAIHYASTMKKAHGKPEPALAWEQWNVPSRRDIDWRLVMGAVVFGAGWGLAGICPGPALVSLGEVVVSALGGGVSSAAAGKVSTFAISMLGGMALEHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2H4</accession>
    <name>A0A1E3K2H4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">L198_00953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034851.1">
        <property type="nucleotide sequence ID" value="XM_019173125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2H4"/>
    <dbReference type="GeneID" id="30190166"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="525" mass="57220" checksum="6F4D4B20FAE3FD83" modified="2017-01-18" version="1">MACGNLPEGQGTENEEQVNMPRRRQVRRVDKSICQKCQQVRSLYIFRNITYCKPCLEAAIFARITKSLHPPLKPQRSTSRLAATSGHRPPPQSGAALVCLSSGCGSTTMLDLLLSKQYIGKGAGLPIDRTKGEKEPIWSKGYVVYVEFGGALNVEERTKDIREWVEQRQEGLEFIGVRAEDVYDPAFRSRLRQLGGAIDGEEVSDVQPLSINLKDSDLPLFPVASSASTTTPLDQLRTLLASLPPASRPQILSHILSSLITSVAHALPNISHVLIGETSTRQAQRLISGTASGRGWQLPLELSAVRTEPPVAGTDSRGFVWLKPLKDLTTKEAAVYCHIKGLSQWTRNDRKWEVAGPVGKRDARGKGGAASLEMLTEQFIAGLSVTHPSTVSTINRTGDKLVFPGKEEERPHCPVCQLPIDPSALEWKSRTGLTSLPTKLNPTPASTLSTPEATLAPLLCYSCLTSFTPPTVVSKARLAEEGNVENVALPLWIREGVERRNGGGAGMPVGREAMKEQIKDFLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2P5</accession>
    <name>A0A1E3K2P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034730.1">
        <property type="nucleotide sequence ID" value="XM_019173004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2P5"/>
    <dbReference type="GeneID" id="30190045"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="547" mass="58837" checksum="05CD4F8633EBA8F5" modified="2017-01-18" version="1">MSSNDDVLTKSVLPENELKNGDMKTVEFGDGKVLVSKIKGQLYATSAFCTHYGAPLEKGVLSHDGRVVCPWHGACFNVCTGDVEDAPGLDSLWSFTATTKDGQIVVSASKKEVASKVGRVITKKGTKQVSPKGSKSEETVVIVGGGSGAIHAIESLRINGFVGKIVVISEENHAPIDRTKMSKGLVDDADKLQWRKPDELKDAFGVDFYPGTAINLDTQTVSTSSGSNVKYDHLILSPGGTPRKIPIPGADLSGVLTLRHVPDTKAITSSLTEDSEVVLIGTSFISMEAAVAIVGKKPKSVTLVGMDEVPFEKLMGKEFGQAIMEGMKSQGIKFHMKAKIEKITPSESDPSHVGAVHVEGLDPIPANLVIMGTGVAPATSFLKDTLKLEEDGGVKVDEYLRVPGHENVYAIGDIAHYVQYPAKFPRRVEHWNVAGNHASRLAHTITHPESPVAYTKVPIFWSSIGKGLRYLGTGAGFDDQYVDGSFKDLKFAVYQAKEGKVTAIATMQRDPIVAKASELMRLDIMPSIDDIRNGKNILEIDLAEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2T3</accession>
    <name>A0A1E3K2T3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional repressor NF-X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034917.1">
        <property type="nucleotide sequence ID" value="XM_019173191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190232"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1318"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1330" mass="143551" checksum="56D93368F00134EC" modified="2017-01-18" version="1">MAESSKPTNSESSQTRKPAPNGIAPVSGGPSRPGDGSYLLEQTTRAENGRRQGQRGRAPTRNGRQGERKKQGNGRETQQGTAEGSSASNSRGASKAPSRRNSFARAQGKKGKKPAEFPVDSSSAVSAQISPNVEQGWTEAIDRSTETPGPNGDGVSDSAPPKLQIDYSLNPWEDAGSSTNGPSQTPSGERREVNARTAGPQSRGQNGRYPQRHNPQHSHPTGYHGMQYSVPSFAYDPHADGEGATNGQQSHVHSRGCDHSGPSNSSKGNMRPAGASNGFSEEVVELRSPQPFFPNAAVNNTVRPSPALMRSLNSVRVPQLREAAPLDAAALSFVPGAALLATDLDEHPSSPKTAQREEAKTTGKKGKKGKKPNQGVDTTQQGPTVATGRRAAFEQSTKLTSMNPKGGKTMKPGQKEDPAQAVVRAEQQAKKSAGQESDDLVTRLTKGLKNRPFVECPICFNSITPSQQTWCCLPPDRPPEPSSSATLHVNPITGSTATSTHYSACYTPFHLECIRDWANRSLGEEDEKIRSGLKEPGEAQWRCPGCQKRRTDPPGQYKCFCGRLSHPPTSTIAPHSCGDSCGRKRAKCGHGCPLPCHPGPCPPCNVALIVPCPSHNIPMTVKCSSATSNNAALSPVCDDICDRQLHCGHRDHACQELCHYGPCAPCMEMESVTCYCGEEEKQVECGWGRSNVKICAKILEDGIETTWEGRFDCGKSCERYYDCGKHKCQKTCHPHPVAALVCPHSPEIITHCPCGATPLSSLPGFPRPDCLAPVPTCKKRCPQSRPCGHPCPKNCHTGECPPCHEEVMRTCRCGQNQLVVPCDILRERMANGTGEVTCERVCKALRNCGRHECGRLCCPLWGQVKSQKKKRNDDNDIYTNDDLHQCHLTCGKMLSCGRHTCPKPDHKGPCGRCLQASYDELICHCGRTIIYPPVACGTQIHCPFPCTRPSPECGHPKIAHQCHENEECPPCPYLTEKSCACGKEQHVKNVRCSQDRVSCGQACGELLSCGFHRCQKLCHKPGECDPCAQMCGKPKSICKHSCTAACHAPKRCPENEPCQAIVTQTCSCGNLLSRTSCGASTLKPKSREAEQLKCNSECAVRQRNARLADALGIKQPGDKNAEVYEDELKNFALGNHKFVKMVESTFEEFFKGPRQSMVLPHMPESKRTIVMSLADHYRLTRELIDQEPNRSVQIRRRIDTRIPKPLLSAAVNPSQAGQTRLVTTSASPWGRTTAGSSGTAASIVAGSGSGSGSSRLSTTVTPVAGGSGLNSTVPSRTTTPVIPAPFVPSIPASVSAKRSEAKKREEGGEGENKPVGQVDDDDDWDKDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2X6</accession>
    <name>A0A1E3K2X6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035015.1">
        <property type="nucleotide sequence ID" value="XM_019173289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2X6"/>
    <dbReference type="GeneID" id="30190330"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="41744" checksum="2591D3D7F5ECB7D6" modified="2017-01-18" version="1">MPAQSPMPDISIPQARRIVVDTTGAQIVQEESPATRDSRGIYLPHYTEPVSHIAIDIGGSLAKVVYFTRSNQPLSTSPPSSGTTSPFLPPSQFVAQPAPLVNGEGSSHSPTDSPALNPHTHAPFDPSPPEQRRPTLNGALTPATLAENDGKIALPKSKRKARKAHERHSSTAPLPGGLLNFARFETENIEELITFLQELISSSATANRVSLEKMKQNVKVMATGGGAHMYHDVLTEQLGVEVHREEEMECLIRGLGFVTRVPEEVFWFSEELVYKVSHLSTNADNEVETTESLTIPPSELPRPSPTPPAYQVTFAPTPAEDDPMPHFPCLMVNIGSGVSIVKVDEDGKHERVSGTSLGGGTLWGLLSLLTDADSFDGKSHSMLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K308</accession>
    <name>A0A1E3K308_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034888.1">
        <property type="nucleotide sequence ID" value="XM_019173162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K308"/>
    <dbReference type="GeneID" id="30190203"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="547" mass="59445" checksum="0532E452B23343B9" modified="2017-01-18" version="1">MAHNQPYRPQGQQSHGLPARPAFAPSNAGPSTQNVYPQAHPYMAYPQQGFYQSQAQAAYGGYQANMSGGYPAGGFYPMYNPLFQQMPMQPVANAEGYSYSSAYLGSQTSAPSDTSAAVDPPAKKQRTNYPQASTGQSTKAWRNCSQAGCKFVGPGDQVEIHEEDRHLIYVPGKKVVRSEEEERFARQKGPLPPIQGTSITLNTPEDIEKWIAERKARWPTAKRLQEKEEEHKSAVERGEIPQNGRGKGRKLAPAVMAEEWGREARPMENAGVSRERDGMRGRGRGRGGARGSGGRFGGDERPDVPGGQRQQREIIPTTSEVADAAKLPALGGYDSAAEGSSSSSSSSSSSSDSSSDSDSSDSESEAENDDKKSSPAKAPAGPTKPICKFFAKAGRCKFNDKCRFAHVASEGSSAPRAAPSQKPELDKKQAKQPLQKRSNPFDRPSILGALLANPIQNTVSQLSQTIRFLVANDMLRNVELHPGQAEDEERERNKVTVVGEGEQESDAKLEEHINEKVARKDEKPEKSVEDERLDGQAVESGVEKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K360</accession>
    <name>A0A1E3K360_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER-derived vesicles protein ERV14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035095.1">
        <property type="nucleotide sequence ID" value="XM_019173369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K360"/>
    <dbReference type="GeneID" id="30190412"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="14066" checksum="00443355F34BAFF7" modified="2017-01-18" version="1">MVFFIIMFSDLECDYINPIDLCNKLNNFVLPEMLAHAFLTLCFLLSGQWLAFLLNAPLVAFNVNKVLGKNHMYDATEIFRTLSGHKKESFIKLGFYLISFFYYLYRQVSSDVSSLNKQANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3R8</accession>
    <name>A0A1E3K3R8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034654.1">
        <property type="nucleotide sequence ID" value="XM_019172928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3R8"/>
    <dbReference type="GeneID" id="30189969"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="205"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="60475" checksum="544346F23C853F9A" modified="2017-01-18" version="1">MASEECDALQNDELTVLESIYPTLLTTHPNPQSKPGRLLTLTLPITLPASTQTHLSSTFKPRQSHSETPTGTLTLDHLPPLILRVLLPPIYPLSSPPHSISLRAPLPQSESVENKGNWLPKSVLKSFDSMLGQMWREEKEAMGEGQGVIWKWMEWIVNGDCLAESGKIVDGVLNLVVPPTTNSSAFLASLKSYDATQKHSEFERTAFSCSICWENRKGNKCVQLECGCIFCTQCLSDCWTLAITEGTLESVACPSPLCVKQRALRDKMDSSSDVPSDLLESVVGPELKERWANLKERRMAEIDPSYTVCPRPTCQAAVPPPAMPDTPTSAAPSSSKVIRLADISSNPAPSDPAPPEAPIAKEDRWAAYRSCPKCHFSFCLYCASTWHGPHTACSFPQVSGIVKEYLSHPEGSMERARIEKQKGKANIDRLVRQWQEDEMNRQWLEGRTRACAGCGVRVEKSHGCNHMTCGRCNAHFCYRCGDSISPLDPYQHFNTPGRPCFQKLFEVDSLGEPINVVLPEPEVEGTGDDFDEMDQWDMRLLVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3V4</accession>
    <name>A0A1E3K3V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034694.1">
        <property type="nucleotide sequence ID" value="XM_019172968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3V4"/>
    <dbReference type="GeneID" id="30190009"/>
    <dbReference type="OrthoDB" id="2573119at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="117" mass="12584" checksum="C8275D620B8C37F9" modified="2017-01-18" version="1">MPQNSSPDRSSPIALSPPISIGGRHTQSAHRSARPPRNDRIGGDVVGDIKRGTRGSKTASGGGKASRTKVLLAVALLLFVILTSVWVMRLNRRVQTLGGFGGMLSKAQKRWAQREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4M0</accession>
    <name>A0A1E3K4M0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034669.1">
        <property type="nucleotide sequence ID" value="XM_019172943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4M0"/>
    <dbReference type="GeneID" id="30189984"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="143" mass="15962" checksum="249A2680A5431C84" modified="2017-01-18" version="1">MEGHDPSATRRQVHSAVLSLLVDMVLYDVQWGVLTNYEAWLFFSRSSDTNIFYCSPVVFRMVGNQEGRGEAQEHRTGEEKASEPSIEVRGAWWADEPLRALLGLCLHITRDRLDINEAPGENVDSEAPEIVCVSTSANILAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K568</accession>
    <name>A0A1E3K568_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034869.1">
        <property type="nucleotide sequence ID" value="XM_019173143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K568"/>
    <dbReference type="GeneID" id="30190184"/>
    <dbReference type="OrthoDB" id="2575599at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="40749" checksum="09FAEE4EF089A608" modified="2017-01-18" version="1">MDLPQNGESSKSLFHLTPTQAQGDEMNAGGERRDGDGDVEMSDGPGEEPVSGADTKEQKRGTARLILPQWDIPPPKPIHSSQDLISLLNLDTLYNAYVRPFADLPGESDQPNGVGGEDGKGGGKKKGPPGRRKMEKGYQHLVEDCIDPIPLGTRVDAPSFLPLLNDVLHPPAPPPPFAEGIVEELPKEAFKVARLEAGSQEGYHGGQKAGVREAEEKRRRKRAARTATHDPMSPIQSTFPPNIQSTGGRSSTPGTPMLPVPPPINVRPYHTPGTPRRGTAPPGAGTGQGVHPFSKLGPGSGAGGRPTMPSSKQRPASMEVPNSRKAASRSASPLPPSSLGPGAGGTANQQRPFAANRNKRPGSADVQGGPGKRAKENGSASPLPGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5E5</accession>
    <name>A0A1E3K5E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035156.1">
        <property type="nucleotide sequence ID" value="XM_019172214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5E5"/>
    <dbReference type="GeneID" id="30189237"/>
    <dbReference type="OrthoDB" id="2575514at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="230"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="37249" checksum="9B097F904BAA06FF" modified="2017-01-18" version="1">MPQADDTLAHLASISLPSHSPAPSQYTPHLAPAFTRIYDALENLKHASTASSHASAAQTQAFLELERTVRALNAGIVDDVQRAVEEGVRKGVREGMEGMVLRVEWKEPGVGCAHPQPQPQAQQGQGQQQQREEVRAAPVNATAGPSRPANNTSSPTAWNLSGLTGLGNLSSAAETSQLSSLFSLAQQSQQSQSIPHPAVHTPSHPHPHPIPPSSDTPLSSFSLSTPSQNFTMSREVKSVPDLWKEYTIGWDGQPAVRDIYEGNPRKRRRGKRFRDDSERKFYRRRKKVLEMVEALVEKGVGEEEAVDRVERLRERRKCTLNKLGEIIPEMTSEEIALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5P4</accession>
    <name>A0A1E3K5P4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium binding protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035327.1">
        <property type="nucleotide sequence ID" value="XM_019172385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5P4"/>
    <dbReference type="GeneID" id="30189415"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="42548" checksum="E48420FCE3809D88" modified="2017-01-18" version="1">MNFFSRQKTKSPADNVKSLRDNILRLENATGEGSKKVSRAGASFGRWLGLPGCACSAILATHHLPRWDISDRQLTPSFYPQINEEISRQIAAVKAALSGESDGEPSPDIVAQVANEVYAQDLLSLMVLHLGRFDFEARKDVCNIYNILLRRQLGTRSPTVDTIATRPDIIFDTLKGYANPDVALNTGMILKEMLRYEPLARIVLYSDQFYTFPNYIENTSFGISCDALANMKETLTRHKPMVAQYLEANYDRFFAMYNTLILSSNYVTKRQSLKLLGEILLDRANYNIMTRYIGSEANLKMMMNFLRDKSKNIQFEAFHVFKVFVANPNKPAQIASILRRNKDKLLVFLKEFHNDKDGTLYTFPSLQTLTGHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6F1</accession>
    <name>A0A1E3K6F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035497.1">
        <property type="nucleotide sequence ID" value="XM_019172555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6F1"/>
    <dbReference type="GeneID" id="30189587"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="72" mass="7994" checksum="23BDC50F10883F42" modified="2017-01-18" version="1">MTSSKLLSRAGTEAQARRGARGCRIQQEAQFIEEKKPSWDAVAINPPYVLGEIIHQCDKPESLNTSVAAFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7N0</accession>
    <name>A0A1E3K7N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035393.1">
        <property type="nucleotide sequence ID" value="XM_019172451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7N0"/>
    <dbReference type="GeneID" id="30189481"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16466" checksum="E6EF3F5FDE4A04A8" modified="2017-01-18" version="1">MVVVVEEVRDEAAEHIAPQENESDFETESETDSIFSDDDDFNPTDETFYERVTALKDIVPPETRVSLYKQYRSTAEWAWWSVQSAGTLAWWVSTSALLVGLPLALAIEDEARVVAQEKEMQMQSAGQQQLLGSSQQGGQPQGVLPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBV0</accession>
    <name>A0A1E3HBV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">L198_08293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000067">
        <property type="protein sequence ID" value="ODN73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027761.1">
        <property type="nucleotide sequence ID" value="XM_019180258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBV0"/>
    <dbReference type="GeneID" id="30197503"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN73605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="174" mass="19924" checksum="A4D6EF8D8E2824E6" modified="2017-01-18" version="1">MPLQSPINFPKWIEENKHLLKPPVGNKCLYKGENFITMIVGGPNTRVDFHINTTEEWFYQYKGAMVLKVVDEGEIRDIVIGEGDMFLLPANTPHSPRRVADTIGVVMELIRPGDAIDKMRWYCPNPTHTALTQIREVTFHCSDLDTQLKPVIERWMGDEEWRRCGECGEVAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD36</accession>
    <name>A0A1E3HD36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000061">
        <property type="protein sequence ID" value="ODN74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027799.1">
        <property type="nucleotide sequence ID" value="XM_019180217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD36"/>
    <dbReference type="GeneID" id="30197459"/>
    <dbReference type="OrthoDB" id="2577265at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="413" mass="46722" checksum="1A1F8B713F3DF6B6" modified="2017-01-18" version="1">MPAPPSTPATAKRSNKKTDGDDASGWRWKHNKKNSTICVGPDGRTGEDYLIDWMSVPKNWAAYSDSNDRAKFAATVIYKWLLKKQIKNFDKAKASGVQDRIQKMQKAFDEVLAIQKPTGEGVTEDDLARGIETWEAKIKEKCPFFFTLLPSLKDRNANITAQSSVHQMGDREVSITPSMARRVSSRSDIEDQSVGMEDEADENDDIFSVRGTRANSLSTDITSNNHGVADEPTSGARGAGSLSNGSRAQASLNAQDTPTSGKGRRGNANMNEQLQGLFKDHSTANVKGRKEIAEQQAQAALALEKYKVAEQARRFEGEMTMKNKRLKVEDTRYEAKLQIEQEERKLKRKRDEDDAKWRNVKAQREELRAKDEMAAKKWEFERELIKEYVTEGDTREEAKRKAIEDTKRRFTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD53</accession>
    <name>A0A1E3HD53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027808.1">
        <property type="nucleotide sequence ID" value="XM_019180207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD53"/>
    <dbReference type="GeneID" id="30197449"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="322"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="661" mass="72040" checksum="4D350FC012D9487F" modified="2017-01-18" version="1">MPILTISPHKSQPTPEFWSALTAHKLDHLKLDDSFVPIHGYLEQGKRVVIDRNASQESDDNRVGIDGSAVLGGDAFVAGEKSLPNTMPMRGTLKLFNTIEEFSSTDLKKKVFHEVVQQMLQSFDTDTPLLNTFLLVTFADLKKYKYHYWFAFPGFVASPPWNLNGDLSPANAEEIEEIRALSSKLDNQEAYIVRGSTGQRQVAPLTSCSAFFDQGEQHQVTIAFHDPSSSPSSPGWPIRNYLFYLNVKHNVHTARIICLREGGSSLEGIVNLDKTQNAQEAKAVGWEVNKAGKLGSRVADLGPLLDPARLAAQAVDLNLKLIKWRIMPSLNLDKISQTKCLLLGAGTLGCYVARVLMGWGVRNITFVDSSTVSYSNPVRQPLFTFTDSLSNGKPKAQCAADALKSIFPGVNAQAHAFSIPMPGHPPGKTVGEDVERLEGLVRDSDAVFLLMDSRESRWLPTVMGAREGKVVINAALGFDGYLVMRHGAGVDAAREGAGGKRLGCYYCNDVVAPADSLKDRTLDQMCTVTRPGVAPIAAAMAVELLVSLLQHPLGINAPADSSTSSTIDTPSPLGLVPHQLRGTLHDWKTHLVEGAAYDRCTGCSKTIVEKYKSEGLPFLLSVFNNANVLEQVTGLDKLQEEGERMMEEMGLGSDDEDGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD74</accession>
    <name>A0A1E3HD74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027827.1">
        <property type="nucleotide sequence ID" value="XM_019180198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD74"/>
    <dbReference type="GeneID" id="30197440"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="22420" checksum="CDC798E7FFC99F0C" modified="2017-01-18" version="1">MAPLARSTNAFPSTGTSVPDGGSKPGDRQRYHELDAFNAYNRSSPEEGTNNPGGDVHRVHNAGEEGNEAASKARVSLGIISGAAHQVGEDDDVGGESDNEAPQNEIHSWARRSAMSFRAPEFFPPSSPPDNQPPSPNDSDLLNDLDDASAMGTGWYEEFGVPPSSFNLNPVLESTMDAILERIFSGQDPLPFMESEGLSRMKEGSGDTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HDR3</accession>
    <name>A0A1E3HDR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nipsnap family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_08240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000060">
        <property type="protein sequence ID" value="ODN74275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027810.1">
        <property type="nucleotide sequence ID" value="XM_019180209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HDR3"/>
    <dbReference type="GeneID" id="30197451"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="214"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN74275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="313" mass="34994" checksum="197F1C537EB53692" modified="2017-01-18" version="1">MSRSMLPLRPLRAGPLRLRLRASLHTTPRLARPTKSPAVPAESDAQEDDPKQGGEGFFGTLIYGSKEAKAEGLVAGEGDPAHHPHSALVGRNKYIHEKITHSVPPSSRDAYLSAAEKYYKALIGRGAALGGIKVMGSWENIVGDVGCFTHILEHEGYKGYDQSLRGLRHDPELSQLQSDMLAHITSRQHQLVSEFSFWPSSPPHSSGYPDGGIFEMRSYLLKPGSLLDWEYAWRQGLEARKKFVVPVGAFFSQAGLLHEVHHIWQYPDMETRKRTRDQAWTVGSWSNTVKDTVKLAYQMRSQIMVPTPFSPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF92</accession>
    <name>A0A1E3HF92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome assembly protein SQT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027867.1">
        <property type="nucleotide sequence ID" value="XM_019180141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF92"/>
    <dbReference type="GeneID" id="30197381"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000513">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="189"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="430"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN74984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="467" mass="49249" checksum="E3DC54153B726B04" modified="2017-01-18" version="1">MSAQEEHQEQDQQINDEDIVEVVEDDGDDIGMDSDSDGDNDKYDGEIIIGGPGPGEEDEMMMEEEEGEGEQQREDNSVGVNSVHAEGQSVFTIALHPSFPNPPLAISGGEDDVGFIFCPIPADPSGILPFTSETFTPIKLDGHSDSVVNAAFNFDGEMVATGGMDGKVVVWQRTKPEAASEQATVEEWSNWQKIQELETGTEISWLQWHPKGNVVATGCEDATVWLWNLPSGNTLNVLSAHTMTSTVGLFTPPGKQLLTASIDSSLILWDPRDPSPIWKSSIFTPPNWPDLDPSEHGITALAVSPNGQIAAVGSAGGQVKLVGVAKGDQLATKLVGHAEGESVEALVFVDLLNGATGGNKGVVLVSAATDGKAFVWDVATGRVRAELSHSEPITTVTAHPFPQLHLVTTASADSTLKTWDIRTGALVGTHTGHMGVVNGVAVAPAPGGEGKALVSAGDEGVSLIWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HGW2</accession>
    <name>A0A1E3HGW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027879.1">
        <property type="nucleotide sequence ID" value="XM_019180153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HGW2"/>
    <dbReference type="GeneID" id="30197393"/>
    <dbReference type="OrthoDB" id="2596802at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="499"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="698" mass="76345" checksum="674C552277E48964" modified="2017-01-18" version="1">MPLTMPPLGPLQPPGDTPRVPVRQIMAEFVPSALDFGSIDEEVSRDSTVSSVDVLAETEGDGVRIIKDTGMNDRFLAALDNQLPAHILASKRLLTIIFRKQALDERYGEAGNQHIYSERDLPVMMEETFWRYVNLVMESKALDKNLRGEWRSCGSRNGGVRGWICVRKVDGKVQALSETIMPSMLRETSDHAGRVQRLLEEASKPGGMRVIVTGEKSVGVVEEDGAEVPGMEYWANCIAQFWEKYRLFDTANIMLLSSSEIYLPLERDRSAPNILRVGLPIVRDAGMTGAGDGALTCLELAIASTLSLPAPSHVLPFPPLPNLKIESASSEGQGGTLAGVFTSMCRWAGIRGSKEAGKQRKAKRRRVSKQGQDLSENRFESVRRSSGSAHPFVWARLHFHGCSLSDSGRSLAQHFFGPIGLSDSSIYGWIDKDLAHPHLDDCTNIFSSPPLLPIADPPLTPRANPRKEAPITAAITLSSSPTFSVSQPIDASSAVDLEFSIGSLIDRGRLSDVYSLTSRVPANHPDDLPPLVVKTMRPSTFDDAKGSAGYGTGAGAVDAWEAEVELYGGVLSCLQGHIVPRCFGAPRGLMYVSREWESREINFLILERVGSAVCAKDEDLPLLPEQTKLAICSLYEALHSVGVIHGDIKRRHIRRRADGSLCIIDFEGARRVSDGAWEDEMLADEMEEVKAMLGFGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ30</accession>
    <name>A0A1E3HJ30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027944.1">
        <property type="nucleotide sequence ID" value="XM_019180090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ30"/>
    <dbReference type="GeneID" id="30197330"/>
    <dbReference type="OrthoDB" id="2564630at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN76343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="345" mass="39436" checksum="62D6CED9FB664882" modified="2017-01-18" version="1">MGSDDSLLDNIPPFPPSSDTKRTSSMSLSAIMKGCKDGELAVRHFDSNTISGLHPHLGFSSISVQSTRGKDAGRKASLHNSRQQRLDGGAITTLVPSMYRHVLGGWRGWWKADPHPSDWISVSTDPLYALFMAANRLGQGRQSRVFLSIISSMPGKDEKVLVVDPREEEEKFRSHTVGFDFFSLENIRARNFMRKFSEKLFYKSIPKSYIVETVEITHDSIPWDDIPLGWFQGGATNEPFSSIRWNWLDYLSFNPYDKLVKYGDAQGIIWAERKEIEEMLIRQAREIEEAEDEDLIEEEEETKEALDWLLLGVEEPVHYLYEEDMKEAKIEEGTELEKALHAMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPB4</accession>
    <name>A0A1E3HPB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028084.1">
        <property type="nucleotide sequence ID" value="XM_019179962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPB4"/>
    <dbReference type="GeneID" id="30197200"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="134"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="50482" checksum="5814C480CEE29A10" modified="2017-01-18" version="1">MTAVQAPVSALTDSFKDLSVNAPLAGYSIGVDSQKRAHQKKLLSEAEKKAKIYETSYEPSLDWWTADQKAYVKPENDPLPEGFPEQDHAASDWDGRVLINQPEKFLYKFTPEDIALINKAHDHFISLHLHNNHISRSTFPIPEDSTLYKALRNAEHEINHGLGLRVLRGLPVDEWTREKQLAVFAGVSSYISEKRIKQGLQNVVHLRWVLFLLSSVKGQTSGNQVYHNDGSAGIIGLITLGVAETGGLSQLASVAHTYNELARTRRDIVRELAKDDWVNKQYPDGKPLFFTHNNRVISSYSRRPFFGFYEADADVPPLPTEKHLALDAVHFTAEKFGLDLDLEKGDLEYFNNLTVFHARTSSSDSPTNARHLVRIWLQNPSFYASSIPPQLAALYDRINEGEAHGWPLEAWDSADPYHEFKDAERKGKEGEEEGKEGGVGKPVIAGNAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HXA1</accession>
    <name>A0A1E3HXA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028196.1">
        <property type="nucleotide sequence ID" value="XM_019179829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HXA1"/>
    <dbReference type="GeneID" id="30197059"/>
    <dbReference type="OrthoDB" id="10625803at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN80191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="390" mass="42154" checksum="4E86AEE675587017" modified="2017-01-18" version="1">MANNLRGRSSRAMKMATTTASTGAVPSSVPETQPVCSSASSSQNQSLYLLEIIQTPSAIPPKPKKATPSLARSASETPPTRVRRGRALLLTPCPRKRAKRSYRPSELGMRAWNAKDANIVPQCMIWTPTTVRSPALNVIRKAYPAPCVHGHGIYPQAIQDGYANLCFTDTLSIGTNELSVRMIQDDGIEVIEKSLRKTPLRRSARASRPSLLPFNDEDEDRDNKDWDKHAIGLYDPAHSLFSLPTAGPLPGSPIPAAGYLSYSPLPAARPDSMTPAPHSLSPAPDTDAGEGSAKKRKRSDDDAGYAEADAEDWGTGEGIAGKEKVVTTAVQVFLMERRFYYYRTLIIGHGPISASLSVDLTHLFSPITGLDLTELLHLPSLGLLTLDCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYC0</accession>
    <name>A0A1E3HYC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028240.1">
        <property type="nucleotide sequence ID" value="XM_019179759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYC0"/>
    <dbReference type="GeneID" id="30196984"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="544"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="675"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="715"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN81289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="824" mass="88983" checksum="D71C56FB9D7B2AB7" modified="2017-01-18" version="1">MSSGSSAWAEPPSPSPAHAQPKPILPSFAALTLDPSLHSGPVPPSLPTPSPVSPSLAQPQPIPMNANPLADHGPLTPAPSPGPRGREDGRMDLESLGLENDFLKNWVDQQGALPPRGNVGGWFTAGGGAGHERSADSTAKGKGKAPVRPSHDTDLLLYQFTRLPTSARFNFLNSLVPELRLDEALLVSRKIAPLLRRDFLKELPIELSLHILSFVDDPKTLARCAQVSHYWNALLQDDATWRYHFSLHHLPDGPASLAALASYSPFMKRRTAEKEKSRSSSTPKRLTPFGIEKRIANLPVAKPLPIPGNTYQSIVALSYLSKTNWTTGGLLLAKHVSIDDSVVTSLCMDDSFIVVGMANHAIHVFNAESGAWMRALEGHAAGVWAMVLVSANVADDEEEPDERVGTETPPSWYQPQPASGAYRDNGQSRRSSFTGVAAAERVPPLGNPMGGSRPSSVMGYSSLGQFDYPSGPHAGSSSHRRPSPPPPPSPGSTRKKRREGGGGSDVTGSIKGWPGLGYNMAVSGGCDRDIKVWNVDTGECILTMTGHTSTIRCLKVLPGRPIIVSGSRDNTIRVWNLETGEELHTLRGHAGSVRCVEVWDLGEEGGGGRAVSGSYDHTARLWNLETGECLQVFSGHYAEIYSIAYNGFTDTIITGSLDCTVRVWKASTGECLALLQGHTALVGQLQLEGNRLITGGSDGRVIIFDLTSYTCIHRLCAHDNSVTTLQFNHQFILSGGNDGRVKLWDLHSGRFVRELTKPCDAVWRVGFRGDRVVVLCQRDGKTSLEVVSFRVGEGEKARKKSRPEGSGSRRGGVERMRKLSLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAT3</accession>
    <name>A0A1E3IAT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028538.1">
        <property type="nucleotide sequence ID" value="XM_019179500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAT3"/>
    <dbReference type="GeneID" id="30196717"/>
    <dbReference type="OrthoDB" id="2573290at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="558" mass="62011" checksum="76FE14656C44ECD1" modified="2017-01-18" version="1">MTGKSKLTRPPPLDIDEDPAATLTNSAQPRQAGKGIEYIPPSLESAADNESRKDGVGVVDHLRRAFSLHKYRGPSRKPGGGGMKRNQSDTRFHTKVSEGGGLNATKKLWSYPTFSMRDKRRKEISFEMILKEEIPAPQPHPSPSSSKGFHRPLPRLGCHSKSPTALERDADPTWPPLLPKPPAPAHPPKSTITSAQLASFRKVSAPILRKRPLPQPPAPFTDTGHSSFYHTQDGSIRHAPATIRLVTRPSAPPSPVPKPFGPSANFTTSTPLARRVHSASDVIGGKVTRRPTASLMPRKPVPRFLDVPFEGDDGHISGVTAFTRSPPASTPKPTRTATEFRSPHLPTPPTPKYDVYVDPFAPTPSRRPPDTYDDSYEHYQNTLFADVLNTWGLPLDLLAQSVSRSRRESLIEASKSSHGSRPSRSSRPTDLQIYSKPSIMSFPAVPTHPRLQNHKPSPLGERRILENQVTFQSEPRRKHGTVKKFVSMDERRLRQPVGRVKDIVDIIEDRQGDRTITPVRELGWILHRPSSVSSDNLHSESKRLMNEARSKARPPRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID59</accession>
    <name>A0A1E3ID59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028726.1">
        <property type="nucleotide sequence ID" value="XM_019179245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID59"/>
    <dbReference type="GeneID" id="30196448"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="817" mass="87061" checksum="A0D85D3CFF91C104" modified="2017-01-18" version="1">MPASQPPSSPSPSHNPAQSYPSAQSHPSLNHLSTSSTPSAASSPPRTPTSTRFPISNPSTPISLRRSPPSTPSPSRFAATPYTLSPPTVLRSPRPPAIPQFSLSNMVFTSQSNYLAAKVDVNFEQGGVVDMIGGPNTGTSYSLPGHIVLTFNSLPAPLEGRLREIQSLEVVMEGKSEFWDDAGRYTPMRLHSQTLSLATPSSPLLIPSTDPSRPHAAKFQLALPFDMRLPGWLPSTQASDMTATSYGCLVKAVVGWTGPSSSSSAASSSSSASSDVFMDDILPSRPYTKTSPASRLFGNSSLLPSSSHPSSSKFSSFTILRHRIAPPSSSAQAPEVQERHFTLKPEKDSTSPVECVVSVPEFVDVNGEEKSLKISLRIRARKDVFNQPSASSSSTPSEQSTQTEAEAEESTGELESVPMERESRQKKKDEDVLTRMVELGMEVEEVEWFSSTPSASFLSTFPVPDEQPSTHSSEHKLLSPPSPNLSSVFGQQDRPFKGTRSRSCLLSEDGNQRNFFFADEGLGLSEKWRKVNVVLPMPELGSHSQEKGVNGRPQAEYNGPFMRVKHTLKIRIVCKNAHGDDAQVVLLSTPIRFATCPTTLPSRSAKTPALPAYIQLFLENGDLRECDPLPLYEDCLPPSPPAPTPAPSAPVLSPGALTPLALVAPSFALIQPTPTTATPSYQSIFHHPVPVPQALPSPSPSTSSLEGCSSRSASPTPSSFAGSSVGSTTDLIGQLGSFSSPLPSFGTFGNLREGLGLGLGLGAGMGMEPRRSGSPALSSGDEDEAMSGSSLQPQRSQRPAGSKVMRPLSQRSAPRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFU8</accession>
    <name>A0A1E3IFU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029009.1">
        <property type="nucleotide sequence ID" value="XM_019179090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFU8"/>
    <dbReference type="GeneID" id="30196287"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22197" checksum="F57F8E16ED3EDA42" modified="2017-01-18" version="1">MSHLADAFWQPFSQGALRLLPKRGDGLRSKSKRADRIPDQAERPLVTDYHSINDPSIRIRVPKKVPTPVKVEAKVWFANERTFISYLSMGLLLSTIASGLLFGAHDSPSRSFAFVYAAISAGVLIYGWAVFQKRLTMISARDAGSFDLLWGPLLICAALFIAILANFIFRLQDAKKHTGINPLSFQNAWYQAGVKSTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGP4</accession>
    <name>A0A1E3IGP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028880.1">
        <property type="nucleotide sequence ID" value="XM_019179122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGP4"/>
    <dbReference type="GeneID" id="30196319"/>
    <dbReference type="OrthoDB" id="2409325at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="478" mass="50696" checksum="DA3641545D02DF09" modified="2017-01-18" version="1">MASVETPQPRENRGPVEELIYKRTKALGKKIQRFKAYASQKPESLNEDQKAGLASLPLLEGIYRELEDISKQVEYVELEQAGKVREMKEQSKKDAEAHGLTKIEEFQTSLSTPLSLFIRLHSLLHPARPSDHDHLTFGRLRLPSNMKEAVQATDVLRVGRWYDDLRAGGDRGKVVIGILVKGPQGTNEEDDRVHHLLKLLEESDSLPEEAEEEERQAEEAVAPTSQNASRSLTFNFLQDDELVAPAGTQPTVSEPPAPTPAPQTTQPPAPSAVASFDWAAEDDETSPATAPAPVSSASQASQPTQPEAKTSNDADADQIIEENVAANSHVLSGLAGTDAKQAPPTVGGQAAAPGPVKTVPSGPKKGRGRGRGGQGQPKSQPQQEQSPAQSSAQGGENGLAADGKQEQTPTPNGQAGRGGRGRGRWGRGRGGGRGGKASSGSTTPVEGKPAPQGQQQPKAPKPSKPAAQQQQQAEPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIH9</accession>
    <name>A0A1E3IIH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029079.1">
        <property type="nucleotide sequence ID" value="XM_019178985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIH9"/>
    <dbReference type="GeneID" id="30196177"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24265" checksum="9BC7601372847E2F" modified="2017-01-18" version="1">MRILNIVWAVFAFLLLAAGVISIVASVIFNSAGHPFLNMIATKVDFKLGIGMGVIYIMSCIVSVPAFMASFENPVMLKFLNWWLVGCMAVTLAFGSIFWVLSLEQLNTFSNVWKAQTSTIQQTIQDEFSCCGYFNGTAEGGFSTTAGFCSDATFAAAQTGCQNTITSASSPGTDFTLETIFSTVYGFEIILVSFFLATVCLINERGISVRFKRIDAKRGGSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKP3</accession>
    <name>A0A1E3IKP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin cross-linking</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029447.1">
        <property type="nucleotide sequence ID" value="XM_019178540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195696"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001012">
        <property type="entry name" value="Actin cross-linking, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1396" mass="151298" checksum="6F6EA48890DF74F0" modified="2017-01-18" version="1">MAFARFGASKYRNAAPAIPPPATWYRGDLPPLTPSAPTTFTSEIKTTREYIITVAPTGELSLRGYAGQAASIKVGSGGGVGDWDVSRLEDALLAVGGLDGAVSVYVLPAPPSTTQPSLLYSIPPSSSPVTNIAFHPTTPGILLISTITQPAAIYDLHSNPKEPKIILNAREPKGLWTIAWKNDGRLIAAVGRSGTAYTWNPRSSPSPSFSKPLQIQSLKPARLAWVGEDIFLTSFSKMRVRQYSLLSGSDLGTKFEQGVDTNQGTLVPLVDEQRKIIFLAGRGDMTLRQIELSGAQGFQESIHPLPFPISSSSLAGVHAGELEVMQAEIARVLVKGEDKDGVVLLPVGVRVPRRQLIDFHQDLYPDIPGSIAEQSSEEWFKGDDKLPLPISVNPARRGMWEKQVGQAAQSRQRTSAPPSAVNSDVTRVAEDESDSPAAAEEAVEAKEAPITTPSTTLSTKPTEEDKPRKDIASTTTVSGSEETKTPTPPTETKQSTEEENTVTSPVGSPDALAPKAEEPPKQPARTNAPATPTPEEPLPSPTPTPTAKTALPPLQEGETHSSTSYKVRIIGDFLADQVVEWKKGEKGKGPLMVGLQGPQGCGKTTLTGALVDYLSDEKELVGAVLSTDDLYKNHAGLKAVAAKHPTNALLSGRGPPGTHDLDLAERTLSAATKLNDSPGAYVHLPIFDKSKYGGEGDRSPKTRKVVGPVDVFILEGWSMGFAPLGEEELEKAYKDPKAASPKTSRVFFPDYPLESLKTLNEYLQPFASVLYPFFSSFIQIEPLSYDYVFQWRLEQEHGMKAQNGGKGMGDEEVREFVGRYMPGYELWAGGVWRKGKGWEGEGTGLRMRFGEGREVVEVGKPGEGYVDHSPSAPVEDGKVVEKVSKPSPERAGSVPAAPTKRPEAATSKDSPANPKLTATQPPTNPSTDRFNPSWSRKYLAAKSPLIPSYDSLPPLSSLHQDSHVLRLTPHLAFFPIQGTGGRLCVQPLKKKGRVAVGGEGYLSGGVEIVDFDAELGEGRRVAVAGEDGKVRVWRVGEEGVKGVGPEPGQVLHGKSIDKFTQILFHPTAKDLLVGVTNDRGVANIRFRDLSKGEEVKQVEVPAPAVYRLAFSPSGDRVAIGSKDGRLLVFDPRDTSTVVSGKAHDSPRSFQISWIDEEHIVTVGFSRGSLRKILLYRLPTTPGEEITTISSLTIDTSPSVLFPVYDPDTSILYVWGKGERVIQAYEINPSNEREPVAKLPGFTADNPQVGVVWLPKRMVDLKKVEVGKALRLTAKALEEVSFTIPRNKPEFFQDDIYVPTTDIEATPLTAEEWLSGKSAERPTINLHPAKMTPLSQAPKADTSTKKKFVPAANVMSEEEKKKNEMDRLFAKAKMDESSDEEEEEEESKGLDPPDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKR0</accession>
    <name>A0A1E3IKR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029472.1">
        <property type="nucleotide sequence ID" value="XM_019178565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKR0"/>
    <dbReference type="GeneID" id="30195722"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN89187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="348" mass="38897" checksum="107F7A997DB00D1B" modified="2017-01-18" version="1">MFIAIIGTPSAGKKVVLQYLEKKYGFQRLRFAKDQPKEEDISGRIAKIDVNGDGQVAAAHTYANANDLLDFVTHNWLSHFVTTDLTSFDDVEPFVKRPFFLLVSVDGPLIVRYERERARAESLKQTLSLEKFMTDHDALLHGPPPQTSSLPTLAHMQLQSDFRRVLDLAHIQVNNNFADISALHWYLDRLDLLDEGRLRPGWDTYFMTLASLASHRSNCMKRRVGALLVRSKRILSTGYNGTPRGVRNCNQGGCSRCNGSARGGEALNECLCLHAEENALLEAGRDRIGDDSVIYCNTCPCLRCSVKIVQCGVREVVYNQSYSMDEASAMVLKEGGVILRQLSMPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL33</accession>
    <name>A0A1E3IL33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029513.1">
        <property type="nucleotide sequence ID" value="XM_019178606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195763"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="9">
        <location>
            <begin position="1197"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="3028"/>
            <end position="3363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1881"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1928"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2124"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2280"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1881"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1892"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1934"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1985"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2013"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2031"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2048"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2300"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2329"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="3363" mass="370012" checksum="71131A936C1ECC1D" modified="2017-01-18" version="1">MKVKKSNKKQNPPLIIDSAQPDDVAALINKISSASDEEIAEVLEQFQAWRYPRGDLHTWVLVLDRFDEILAGVIQNYDLTKLQLNDFTPKTKKLLLEVLRVQRLLLENCTNRKLFNSYDRLSDLLLTNDLDVLQSAIFVLLRPAQQYAITTPLEPAQRQAILHRLVVLSRGWESLVHSGINLTSLASDQEIEVPDALRHVQVSFYPTIQPTGAPGEKSPIKMLSSAAVETPTRQRPVPHSKNSTPMARQVAITAPALSGPSLIDLGDVSISMRENFVDQLSALAEKEHIPLDDQYSVLNRLRLVLLMGDRCTRRRLLSIRLLALATYVYLSSEDAAQSNLFLYEPEMVSQLADLMRSSDTVGEDVTTGALIALCACAHHQNKMGEVMTSVSVNVNHGVMVTFLRRLVQRSTEGEAMSFEVIDATMAFIAYLATSPSHSNMLMGAGILRLLLEMLKTTDSKRETCIPRATGLIDSIIFSNPQGLSNFSGIDGVNALVLWIKSEIQQRLQTVDEAPSETMSEDTILAAVNNPLKSVLRSIQRLMQASGGTEGLRNLVDSDLPRSLKVIFQNSSRFGPRVFALAINTMATFVHNEPTSLSILQEMQLPQTLYDELEKDIPPSSEVLSSLSNAVGAVCLNQAGLDYTVAHPGIISNLVYTVVSPRHEQIFNERDNAKNLGLSLDELARHHPSLRPVIIIAVINVLKKAHEFGARFEPKDEERLDYLVDEISTQMVPSLETQPSKPAPTNKPLAAFTRVFKMLSGLLRNPTIVKDFVNEAGLDTLMLMTDSPCWPIRFGATTAAMALAHLMKYAIESCHAQFLDTIIKSIEASLGQSTEVWKVNDAIDHWQTVREGRANDSLKMKFRVLQSIAVRLTLFGDALYALSGSNSKVATAVIKSFNVQNDPAFIQSLGKVHRLCFRFHVLSRPPKAPPVEEGATPEQATEPGVRYLSTRLHAILSKFFKCLVRLIYIKRGRDQAHQEQGQLLSACVADILIDHLSDVPDSLPDAFAIDGFALGTVLSTLFDGRGLEGHLNTSLFLVFERKGGFDKLLESSRRIVDHIDHASTVPLENRSQEEKERHEEALQALKTVLFMCNTFVSTRALLGSPETHALASVQPGQAQHPFAPTTMFLKLRLAVFPLARHVWGASWLLECPTFIIKAVVNCYSTLMEGKHEEPLAIPAVASRGIHIIAQHHRPPVVTADSGHIDQLVDMGFTRGSAAQALVRARNNVTAATDLLLTVPHEFESELPAPPHDEAAEEVTDDAPAPVENAPPPAQDAEVEEPALVGTGIDVDPAATADDINSFKQQLHDLRDKDKGDLAERALAIVDVAEDLVMDLLSCLPSGKEGAMFSLNKLLDICREYQEPSERIVSARLRLASVCLRSEEGTSIDASVFAISATIIACLPLSLVNHNTSKPRWLTGLLLFGETLLSSYDTIVKVKLGDDSSVPVTEPAKVLGGVTDPLFLLCSTLVSSDDASREELVASLRLLVLLSRSSKPASTTAMLSNCLKPFRKISGKLEGCYSLLAMIIRHLVDDKWTLNDIIDGEVRSWLSPGRSKVVDIQHFVKQLRPIALREPSIFANAVEKECTLVDPTPSQSVYHIRSQTEEERESGVSHVSSTNTGLQESKHCQDVIDVILSELSEAIPGALSKVDSPSTSRDGDDFDIFSYSSLLMATLTELLGSYLVIKKTFLASLSQRVYPGGIKSKGGVNGVINDMVCCVILTPDVMSLPSTDSNSAAARRLAISSRATAMIVALCSDTTPALDKKDTSEDMVSIRKTVLDAISKAIRDTSLVVDVNVRYGRLWALGELIHRLLVARSNVSARQINSSGLHMAKTMLEKNYVGLLTNALGEIDLNYPDIRNVLVTLLRALDHLSKLSVKWGKASKDTKDSVDERSSEDDDDSDSSNAETDSDVDMLDEDQAPDLYRNSALGMLGGELGEDDEDDEMDEEEDEDDMEMGDDLTDDDDDTATQTSEDESMASVLDHDEWTDGPEDDLGDSDDEGNLGELEPEVILGSAEEDGEMWEGESDGHESFGTDEDEDADGEGVHAEGIFDDGFDDPEMEEFDEDDNGEGYDDAEIMEAFPEVVATEATGPWGWVQPGRSRTHDPLGNHRLLPGLSDEEDELLGASSAVGPSGRPAQHPLLAHTSSTSGARQLHRSLGGNFQELVTAIERLGGADAIHMLENVLANRHITGSDATWLSFTRDQLGNLTAMSVNGRTFPLNGNNRSNAPPGHISAEFVPMTTLQRWGEELNLAPISRTEGTSRLVLHLINRLLPEARRRAEELRKADEATTTNAPTVLEATESTEETEDGDETAEIVEGGDSAPHMSISEGDVEMSDTEDNTSGQAADDVERSENVDVDGPRTLISIHGREVDITDAGIDLEFLQALPDDMRADVVEQHLREQRQHQRPAASANIPEPVSQINSEFLEALPPDIRAEVIMQEAMESERRNRPQPPLASGPSRTFLSSIANQLRGVLGTQGEGSGTAIKAERPDGAKGRHREALQLLEKSGIAVLVRLLFFPHALKKSSLFKVLVNLCENSNTRNDLLDLLISVVHDGSGDLPAVDRSFQQMSLRGTSTPKATPKGKAAESPAAVIPSSLFNHLQAEHVPTFITQRCFEALAYIVTSNAHAASYFLSEHEQTAGLRKHSSKKSKGKEKSLPQTKFPIVILLGLLDRPVLAKTPGLMDTVTALLLTVTKPLAERKADGDQAKSALAAGGDSSASANDAARITAVQSAVEPTKTLPHGEGIPSIPAPVLRLIVNCLTSGDCTSRTFSQTLGAMQNLSNLPEGKDVILQELCLRCRDLGHLANEQLQELVNALEVEADVGPLTLISFSPPSSAQAQLLRLLKTIDYLHLNKVDPDPPSEQMTSEEQAVTQIFGTFDFGELWEQLGRCLSMVEARGNTEQLATVLLPLVEALMVISKYKSHLPRDTRSSSTPPSSTESADFFVTFTTAHRKVLNTIVRNNPSLLSGSFSLLIRNPRVLEFDNKRTWFFQKLKKKKSSIVPPGPLHLNIRRQYVFEDSFSALQRWSGEELKYGKLSVKFRQEDGVDAGGVTREWYSVLAQQIFDPNFALFEPCAADQQTYQPNKMSWINDVHLSYFKFVGRVIGKAVYDGRLLDAYFNRAFYKQILGRTVDMRDLESIDPEYHKSLQWMLNNDITGIIDVRFTTEDDQFGEKKTVELKPDGANIPVTEENKEEYVRLVVSYRLDNSIRDQIKAFLEGFYDIIPHELIQIFEPDQLELLISGITTVDVDELKNATQLSGWKSTDPEISWFWRALRIFSQEERSRFLMFVTSSSRVPLGGFAQLQGSSGTQPFQIQKLYGKEGGLPQASTCFNLLLLPTYTSYEQLRERLQFAITETGGFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMN2</accession>
    <name>A0A1E3IMN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic checkpoint regulator, MAD2B-interacting-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029584.1">
        <property type="nucleotide sequence ID" value="XM_019178428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMN2"/>
    <dbReference type="GeneID" id="30195577"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39029" checksum="00DC6E900E1538CE" modified="2017-01-18" version="1">MLLANYGSDSGSESEPDAPPAPPPAPKPTTAAQPHKKKKPVKITLDLPKSADAAEDEVDGEKRKKGDADSDDERAPKKARLPKGGKGNSSLLGMLPAPKRKLPAPPSASGSGSKGASGLVVNKAMARSQLPAPPKLAKAEDDSDEEESVLLPPSLARKQNKEEVVDLFGLSPALKPKAATASAIKPPAISSAPLAPDFVPPEPTSSDAYPGYYQLPSGEWRAHDPAYYASFFPSSSAQQEPEEGEDGRVGKHWDAFEKGQFKGQILDIDANQGLEEARKEAERRELMKKPKAPGDEFVYQASRRVVQRCKLTVSQPKGQIKGLASQRHQLTSLLSTAYSQREELEQRIAANKKGMQGAGHKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQC1</accession>
    <name>A0A1E3IQC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029909.1">
        <property type="nucleotide sequence ID" value="XM_019178190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQC1"/>
    <dbReference type="GeneID" id="30195336"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="94" mass="10653" checksum="30BE16FC23C8CF75" modified="2017-01-18" version="1">MTAESLAAQRQKDLQNSRNSHARIKRVAQDHKALNHKIADLESRISTVQTSLTMSEEEQIELFNAWAQAKAERGKEDSQLEFDKVLDGQTSNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRS4</accession>
    <name>A0A1E3IRS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029949.1">
        <property type="nucleotide sequence ID" value="XM_019177910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRS4"/>
    <dbReference type="GeneID" id="30195046"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="332" mass="36372" checksum="133DF5C12D328E1B" modified="2017-01-18" version="1">MSSIPTTTVAGKTVGRVGFGLMQLTWNPNPPSQEVSFAAMKAAVDAGSNLWSSASFYGNPGDNFANIKLIAAFFAKYPEYKDKIVLVVKGGVNYTNIHPIADIDYWRNEIKQMQEILGDKKLDVFSLARLPDAPVEEVFTNLKTLKDEGLFDGVAASELGAESLEIANKITPLAINEIEISLFSYDTPIRSAIAWHTKNKIPVFAYSPLGRGFITRTYKSPEDIPEGDFKRMLPRFQGKAFYENLKLVDKLDEIAGRKGVSGSQVALAWIVGLSEYTIPIPGSSNPTRIAQNIQSASISLSSAETKEINDFLDAFEVQGTRYPGAAMGQLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUM1</accession>
    <name>A0A1E3IUM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030037.1">
        <property type="nucleotide sequence ID" value="XM_019177998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUM1"/>
    <dbReference type="GeneID" id="30195137"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="285"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN91411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="535" mass="60028" checksum="B94EDB66869BFFC2" modified="2017-01-18" version="1">MANRMRAIFSTKHSLTLPAPVLHYIEDILEHIEEEEWVNGLEHWAKEYLKAEDSSSLVSLPALKKAFENLQMGAPDDSGEADPSEVNVESHFSVIDAFSMPPMRFDPVRAGFVSARTLPSIAGQANSRSAFLRERWAIIKEIVLRNENFTPPAIGGHDRANYLKLTSTRNLLGRSGQLFLLFGMLSRNEQGALCLEDGEGRVPLDMDDAVPGEGLFTEGCMVLIEGEYTVEETVRVFAMGHPPSEKRDVARSLHGHVDFLGGGAISLKEEQKYTPAVLANTQVSFVILSDVWLDHPRTLPALQRLFEGYANAAEFMPMVFVLCGNFSQGGWEGPEGLKRYTMGFNALAEILHDIPLLKSCHFVFVPGPSDPWSSSTLPRPAIPSAFTSRMLQRVPQARFVSDPCRLKYFGMEIVVCREDLMGKMVRNLVVVKDDAEVDMKRYLVQTILDQTHLSPLPLSVRPTIWEYDHALRLYPMPSAVVLADKYERYDLTYEGCHVFNPGRFVGGVGEEGWEFEWSMYYPATGRSERSVLTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVS6</accession>
    <name>A0A1E3IVS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030324.1">
        <property type="nucleotide sequence ID" value="XM_019177573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVS6"/>
    <dbReference type="GeneID" id="30194704"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="41788" checksum="5720D2F95793C554" modified="2017-01-18" version="1">MAPIPPSSSLPGISRHLNDIRTYQLPRLSSPSGAPLPTQLFDELVEELRVDLEGVRRGLEREKEMIAFGAGGAEAKAGVDEAEREYHELKSLFRSTVVQAKKNMAVRHARMQELSRKGSEKDESASKTTPVEEKGAARSAADMGIGGDDELQTKTNEVTSALRRTTALMQTELERSVLSVQMLESSTQTLTLTQTLHETYTSLLTSSHHLIQTLSRADTLDRYIILASLFFFLLVCGWIVKRRVLDKALGAGWWVVGGVGKGVGWYVGGSWRLVKMGFGGDGPATRPEGLEVNGFVDEGALPRVGQDSAAGSLDSEFEYIKPHAANGVDDYVAVAEPAPAGIATGEKGMNEIMRDMEKGGRVKVEILDNNERRPGQPLLAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVT9</accession>
    <name>A0A1E3IVT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030295.1">
        <property type="nucleotide sequence ID" value="XM_019177544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVT9"/>
    <dbReference type="GeneID" id="30194674"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF51">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="510" mass="56480" checksum="118CC2A4C065439D" modified="2017-01-18" version="1">MSVVYLADEKAPHLTDELDGETTSQDLKDGVEEVAQQDADAAIKEKFTYEQEQKLLRRVDWRLLPLLILAYLLKNLDGNSISYARVISSGKSTNILKELNITTDYYAWTSTIFTIPFILAEVPSNLLIKKQTPRLHVLRIVVLWSIAAGCHAAAQNGASLLTTRFFLGLFEAGLYPGILYHVVCWYRPDELAVRMAILGLLGQFSGILAALLAYGIEFIDGRGGISAWRWMFIIEALMGAALALPVYFFLPNFPDTAKWLTPDERHFLVARLPPNAARATDKAFDKKGISDALKDPLLYGFTLMQMFSNLGAYGLSFWLPSIIASFGFTTTQSSQLLNIPPAVLGIATTILFAWMIDRTFDIPRPWYGVVSKVVTIGAFIALATVTNKPALYALTIIATVGSSAFGAVMMPWRAQSLNGSTNAAFAFAFQNGLSQISGIIGPQVFRSKYAPRYTIPYVVCIVFLVLSFLALLVTWYLSAALEKETRRVAKVRRAEAKANRITQDEVVFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWJ9</accession>
    <name>A0A1E3IWJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030432.1">
        <property type="nucleotide sequence ID" value="XM_019177681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWJ9"/>
    <dbReference type="GeneID" id="30194813"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58303" checksum="888C616446036F5F" modified="2017-01-18" version="1">MHQQRRPHGESSTSYRALLTLLQHTSALGLLLACTPALATPLNRPPQQAPWLASPPAALPSHPWTSQSNADHDPTRLLEKYAPILKLSKDEKYFPSTVDYMLPHYEYIENISGDSYPANHTILTPSELDTLPFSGSQLFLSISEPHNPQPALLNAESHYLYGPAGQKGGIDFSSEGGRGRVNEPVYGFWVDQGRGIVDLWYWTFYPFNFGKPAGRFGVLGNHVADWEHFRMRTVNGTPISADFSTHEGGYLSAGTLRWEDVEKVGERPVAYVAMGSHGIWPDPGEHIGNILKIIDSTDDFGPIWDTKSHVFPVQYWTNSSDRQKLQHEGEDSWRNFEGYWGNKGDTDCWWHGIVGICQVVDAPPGPNRYFGGPPECLLAPISSSPASTISFYLSSPAIDWATNNSIAMVQVEQICERPKKDRGGEDVQNMESDTDYANDDDVEVYGVKGLTNFVGDEKHSIELPACKGLQSGVRGYRVSLCLLNGRCLSTSRERKICAYEEGKRGHKAGSAVVLDDVDDWLWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXP6</accession>
    <name>A0A1E3IXP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030495.1">
        <property type="nucleotide sequence ID" value="XM_019177342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXP6"/>
    <dbReference type="GeneID" id="30194465"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="167"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="532"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="897" mass="100090" checksum="83649516B86C0AD8" modified="2017-01-18" version="1">MVLGFNPLFRLAGLDSDGDDIEAAGGHSQSHGADDRGPIVTGEEEEEEKYSDEEFGPPEPRLANPHTAAGGEGEDEEVYSDEGISPTTVDDPSNSPVPFIQPKLPNTFLDFDSLDGIPPVKPAFNVPPSLLPAAPYILNKHTKDIYVPAHLNQFLKQYQREGVQFLFDRYQAGWGGVLGDDMGLGKTVQVIAFLSAIMRKSATATQDYGRRKRTLRQSGTGTISPQRWPTALIVCPKSLIGNWGYFEYEVLGPDNSEKTRTALAKGYLDILLMSYDTMRGHINDVKDLPFTVLIADEAHRLKEPLSMTTLSIKKIQTRICFALTGTLVQNRIDEMWSVLDFAHRGWAGTSQEWIDFVVDPIKTGHQSEGTAQQVVEAIRRLGIMTTKVLPHFYLRRDKTLLSDILPRKTDLVVFCPLTGKQQKAYTNILASDEIARLKQLNAPCPCGSRKRSARCCQLAEEQYLTEVLFKFMTALSKVANHFGLLYPGMSSLSPRETNMFFYKICTGSDTVSKELSSMQAALDTGNCGKWKVLERLLTQWRAEPCKNKILLFSSSVRLLKMLAKLLRSSSLLSSFPVDMLTGEVDNEERMRMVDRFQDQKQDHFVLLISTKAGGVGLNLTAANKVVIFDPSWNPADDLQAMDRAFRIGQERPVDVYRLIALGTIEEAKYERQIHKQQSAKQFNDGTFEPRHFQGYDGASTLDAQGDLYGAHNLFRYEPNGFVAQNLEDGICDAGDAFLEEDHEDDQEGEDDTHEGSDRVKQGGSQQKKKGRSADEHAKALMEDVLGLSDNPVATVKVAKDILDELGLTSIVHDKAFQDSPEERQIYELGVNLLRDNPELAKTMKANELAPKRKKRPREIAGGNSHKDKDGGRQKLSEKAWKRPGGPNQTRIELSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXV2</accession>
    <name>A0A1E3IXV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030529.1">
        <property type="nucleotide sequence ID" value="XM_019177376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXV2"/>
    <dbReference type="GeneID" id="30194502"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="162" mass="17548" checksum="6C18BDC899676778" modified="2017-01-18" version="1">MPLSHHATVTLSIPPTRQGPKRAETVQGRLWVTECRVIFAAHSMFSTTQSSAASSDPPGYDATPALTSFEIRHTSIQSCTYNLPTFSANYILLTFLPAPGSSLPDPGTGQSLELKIVVGQGSGHRLWKIIEGERSRAEERGTEADNEALPVYEPFGSVPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0C6</accession>
    <name>A0A1E3J0C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030516.1">
        <property type="nucleotide sequence ID" value="XM_019177363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0C6"/>
    <dbReference type="GeneID" id="30194488"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130138" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN93411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="22062" checksum="5355B43D8E6E4001" modified="2017-01-18" version="1">MRFATYVLAASAAVQSAMAGVYITSPVNDTAAIGGQVLEVKWADNGETPTVADIGPCDVSIYTGSVNNQIKLQNLAASVDVSKASSISATIDPSIGQDDSHYFVRFTSLSLKDSTNSQYPYEAFSSMFSIKSMTGAFNATVFAAIDASSSSSSAVSSSGKASSTASGSVAADVASATKSSSTSSSTSSSTASSSAALTRVGGAPMALALTVVGAASYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0D0</accession>
    <name>A0A1E3J0D0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030840.1">
        <property type="nucleotide sequence ID" value="XM_019177259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0D0"/>
    <dbReference type="GeneID" id="30194378"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="614"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="895"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN94309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123354" checksum="80CF5F67757E26F9" modified="2017-01-18" version="1">MAAPASMFQLAQLSLEEQHLPLSLPVIDPQFHLPELDEFALGTERLVGSLRGSSGYALQDRTKIPPWNPSETGDYLPEGLPSVGTEKDGEEELWQKLAEEPLAESQAFHPLRTWDPSETNFQTAFLSEGSTATFDAVLTSLEPPIQLPSLKSPLPPPAHDSVHLLDLMMRATLGTVTTEHLLWDAKRSKYGWKESGGRPIGMERITFSRVVEEFLSIATAIRRLELIINSQSLLPLTPTHHALLHAMSTYLTYIRERLMFAISQCEHEGKADWNKWILATRDVNILAQTLCEVMKWPLTSSRASALPTRASSLLSHLYSHLFSALSVCPTPTHSIPIALAFLFSESSGPWMSTLHAWLGLVPSDEEDDTDAKSQPWGDLGITRAKVNDRWQYDFSSKHMPVFVPREARRVLFEAGKSLRILREASNGQHPLCSTEKWDINVQWSWGDDNESGVSDIRGHLKRVRKEVECWKRSQRGSLSGSLSGRKTSRRERKGIPLEFRAPPSTSPPAGFQGEADPESEMERFFALLGQAPGSHLSAPPKKEEPDLNLWAQTPLETLHRFISRHSSPDDPLLPQSCPTLPIFVSDYILAPLTQHAGIVSASLVSLYLDDLRFLDHLDVLRAFWLGGDVDFMERAGGALFGKDSAGAGEAAGLGKRARTRARLGLAPGNDAGERSAEWGIGLGIGLSERSRWPPGGAELAYALRTTLMHDDIGGMLVKENSSVWQEVEDRVSFAIKELPEEGDTGRRARWLNPQAIEALDFLYLAYSPDPIISTLLPPLIMVKYQSVHNLLLRLSRVDLVLRTMYWDVVHQSESFDEPLKMGVDSGINRPPRAARFARRERIVHSLFPKGSQTERHLQSLRFKMSHFVNTFGRYVMDSAISIKWNAMRKRLGKLQQKIPGKDESRPGSPVDDDDGLGSVSEDEGQTDDDESEDNPASLRQLQSIHSLVAYHNLSLDRILRACLLGPQAGQQVTYKVLTTLFGLILDLGKTLKEVEKGFMGWEDGAEKVEEIMGEWAEKEAVFMHALERLSLRTTSSKRYHTEGGDQTEQDMLLLEGEGEGAGVESEADYWAKLGMGGNDLQELVLRLRLRGSTEGKGGRWKKENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1A8</accession>
    <name>A0A1E3J1A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04798</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030936.1">
        <property type="nucleotide sequence ID" value="XM_019176904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1A8"/>
    <dbReference type="GeneID" id="30194011"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="150"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="467"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN94657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="533" mass="59967" checksum="30C199EE14029861" modified="2017-01-18" version="1">MLNAQNHQQGPGRTSPMPPVPQVAQPNIGQPGSVRPIPSSSSPSDPSSALAQSQSSDKGPDYVYFERKPTQFSESVQGKAMGAKMKLELFYKEAVEGVVGRKERRTVLEKQLASDALTPDSLKARQLINLGRRESNYLRLRRTRIGLDDFRTVKVIGKGAFGEVRLVQKADTGRIYAMKTLKKNEMFKKDQLAHVRAERDVLAESNSPWVVQLYYSFQDTQFLYLVMEFLPGGDLMTMLIKYDTFSEDVTKFYMAECILAIEAVHNLGFIHRDIKPDNILIDSLGHIKLSDFGLSTGFHKQHDSAYYQRLLGGADVSGSSGNGGNRQSQVPTGAGARNSVMVNAINLTMTSKQDIATWKANRRKLAYSTVGTPDYISPEIFLQQGYGKECDWWSLGAIMFECLVGYPPFCSENAHDVYKKIIDWKNYLYFPDDVHLSREAEDLIRRMLCESDRRYTVEQLKAHPFFYGVDWASIRDIDAPFVPHLRSITDTSYFPTDELDQVPEAAAATGGEGGDAKKDLAFLGYTFRRYEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1J2</accession>
    <name>A0A1E3J1J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030998.1">
        <property type="nucleotide sequence ID" value="XM_019176966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1J2"/>
    <dbReference type="GeneID" id="30194075"/>
    <dbReference type="OrthoDB" id="10381258at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN94719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="350" mass="40231" checksum="5E69911590B8E373" modified="2017-01-18" version="1">MYQFPPGLSLHDAFFFLPPEVRAIVTHWFTNTPFTQSDLARMVRINKHHYAHFIPELYNAISLDRQNCETFFYPLINDTHDPREALDRHRYSLTEEWSKVNHGVTFIPNAAVRKLACLSCVQRVVLAHTDAVMRCKEAAEIAWYFNESDESSDSRGMAYSNSKLFPAAQWLAFGDQITQKLNTYFNVWMGPVIDLCGSEMLPPVIRAGISVCFHTKSSHKLGWEDDVLRKFSILSDVKDASLHNMYPTFVPCNLEQFERLRVYLPQEKPEGDASVIIEEWIKALRDVVTSAILWMARRGFRIDIYNTDITDIRAILANLEETPERVELWKEILHLHDSSSVESCPGCGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1V2</accession>
    <name>A0A1E3J1V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031132.1">
        <property type="nucleotide sequence ID" value="XM_019177100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1V2"/>
    <dbReference type="GeneID" id="30194214"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF51">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="683"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="82477" checksum="D9BE72C7F5B790FC" modified="2017-01-18" version="1">MFFSDDLLTTKKGSFGIVWLMATLGPRNKKITKKQLAAVDLAKTCELIAEPPEPMALRLSGALLVGVARVYNQSFDMFYADVTTFHANLRRSIAIDLSHPSNTMVGGGALELPNDGQIRSELITIGNTDFDWDMSSWDAEFAHVDWNDPLAPGRKRRASSVLSSSQISPASERDGVDTVEDGYVRDLEEEEDYEFEVGRMAKRSRFSASPAYTTLHRTPIHQRPPSNPLFSRNDLDFQQEVDLGLNLDLDFDGPAGVDDSFSGPSGGRGFEMPLAPMDDYDIGPDMPALMDNMEGPVIFYDEEGGPLGDEQQLPLSLRQPSPNANDLAHNDDYPGPSYQKRKAKQIKKVVFDSSLEINEDEERQARSSYRERMAKDRKDAESKEAERRLGLEVISMVDGAGGFQFYDAEMADMFSSLTKVARFKWEADLARSKSRRKGLISTSDQDIDIDERKERHAVNFPHDFDMPMAPMDDYDVQAGYMQDARQLPDGEVDFGQNDAYYPPIYDDYEVPVRDRDASMARLSDVEYGRRDSVRSGGNLPWEITAGSTPGGAYPDFADTSFSPGSLKFSLMTPQEARIRQNSRSGNNTGSQFARRHRIRSSSLMSDRPDDDPLMLARARSAELDLPSDVDLEDILPSETQQARLADLPDAFRPEMLATLEKQCRDFLTYMEKKMIGLKKENIMFDELVPRTSKKNWAAVAFYDCLTLSTKNIISVDQPEPWDTIHIRFADKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2J0</accession>
    <name>A0A1E3J2J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030702.1">
        <property type="nucleotide sequence ID" value="XM_019177121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2J0"/>
    <dbReference type="GeneID" id="30194235"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="456" mass="48624" checksum="6F95FF26221B0175" modified="2017-01-18" version="1">MAISSASRLALAPPVLNAAHRGGLLLTGKAATRALRHSSSVSPESAGVKRFPPSRTAPKIIHSKATLEEPSLGESALFLKDTESATHFMQALRTPGLSFTDGHGLKGLTGKGRQTRQMNLYQAIRDALGTALAQDSKAFVFGEDVETGVFRCTTGLVEEFGKKRVFNTPLTEQGIAGFGIGLASLGARAIAEIQFGDYIFPAFDQLVNEAAKQRYASGGAYPLPGGSLTVRAPIGSVGHGGLYHSQSPEGFFLGAAGLKVFIPRSPIQAKGLLLAAIRDPSPTLVLEPKILYRAAVEEVPVDDYTLPIGQSEMVRPGTDLTIVSYGTPLHIARRAISLIQSPPPALHALLPPKLRAPNSASSIQLIDLRTINPLPVADIVKAVRSTGRMIIVHEAGRSGGVGNDLIGEVDRRAFEFLEAPVGLVTGWDTPVPLSFERFYQPDVIRVFDKIVETLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3A2</accession>
    <name>A0A1E3J3A2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031309.1">
        <property type="nucleotide sequence ID" value="XM_019176834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3A2"/>
    <dbReference type="GeneID" id="30193938"/>
    <dbReference type="OrthoDB" id="2576102at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="470" mass="51164" checksum="71D0E4599740274C" modified="2017-01-18" version="1">MALSLADELAAFDNPQAGPSQSLAAEFGLDLETELGLGSGSGEFGMDGGATLDDELQFGGGFGRPINPLPTEETAEAQMNTATSSARGSIGSPSRLHDFDTSLSSPPSPSSPMSPTFEEPTTNPSTLYPLDAASHLQGVSSPLRPPNGVRGKGLRSENSWRSLRAGKEDDEPLLVLSEVMTTNSKFITGLRQIDEPHSPLPRANASTSSRSSTPQIKAIPKDTVDTLLHRHLVKMQESERARDEQLRELGVISREMGSVAWGDAGEPSSPRLDLLEEDEEKEDTADLGWVGESMVMPEDAPRLVDEIDRHLEDDGVEEEPFNSTDALLEDPFSTPQLAPSFDPSRTNHPNLPVLPSQTLSVISTSTSLSHALLSLSDSLHTSSSQSTFLSRQIRSLRAAVQGFREREGMEEEAWKGVEHWERSKVEEGLRGGKGFNMEMERVWEEFEGLWDGAKADMDRIRKGQVCESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3V7</accession>
    <name>A0A1E3J3V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031325.1">
        <property type="nucleotide sequence ID" value="XM_019176850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3V7"/>
    <dbReference type="GeneID" id="30193954"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="145" mass="16049" checksum="0B5D766E52A7F061" modified="2017-01-18" version="1">MGSNKPRGLQAARKLRTDRRENRWADNDYKKRALGKFYKTSPTGGSSHAKGIVLEKIGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFTDENDEVLISGFGRRGKAKGDIPGVRFKVVKVAGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4F7</accession>
    <name>A0A1E3J4F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031388.1">
        <property type="nucleotide sequence ID" value="XM_019176460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4F7"/>
    <dbReference type="GeneID" id="30193554"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="39413" checksum="0EA3AED510365641" modified="2017-01-18" version="1">MSGRPSVARVYAPVNEKLGRSWWDYDNLVVQWGVQDNYEIVRKVGRGKYSEVFESIHLPSDSKCIVKVLKPVKKKKIKREIKILQNLAGGPNVVGLLDVVRDSQSKTPSIVTEYVNNTEFKTLYPKFTDFDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRTLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNADQLVKIAKVLGTDELYAYLERYDIELDTQFDDILGRYQRKPWSRFITSDNQRYISSEAIDFLDKLLRYDHQERLTAEEAMGHAYFAPVREAAAKASAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4X7</accession>
    <name>A0A1E3J4X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031558.1">
        <property type="nucleotide sequence ID" value="XM_019176630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4X7"/>
    <dbReference type="GeneID" id="30193725"/>
    <dbReference type="OrthoDB" id="10416041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="230" mass="24437" checksum="C412796597203F0D" modified="2017-01-18" version="1">MSSPPLSPASTRNSFSTAREDNFTSAPQSFGAESHAEEEGGGESTPTRRLQVDTSHQPSSAVDDVASEGGHTPRSPMDFRSGPTPDWDYEAAKPKKAQRMSFVYGTTAGTSSQLPEESAPPASQAGDALPTGDGRRMPEVQRNWSDEVLVGRAPSVSRQSSLASGLVSASEEDDSGSDYAGETRRSVYVPYQSATRSSEGGEGQSQTGEGRRTRRGKMRKYISSCFTGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5D4</accession>
    <name>A0A1E3J5D4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031520.1">
        <property type="nucleotide sequence ID" value="XM_019176592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5D4"/>
    <dbReference type="GeneID" id="30193687"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130144" description="Purine nucleoside permease" evidence="2">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41883" checksum="94DB5F66ACAF16A5" modified="2017-01-18" version="1">MLTRLLSALAIGAAAVLASPVAHGHVEEKRWYPIAPKVMIISMFTPEDVWRTSLNLTQNVTLPGLSPLFPNVACNEAGEICQMTTGEAEINAACSVTAMVLASEFDLRQTYFLVAGIGGVNPYMGTTGSVGFARYAVQVALADEIDSRQIPSNWSTGYFLLGSSEPGEAAGNLYGTEVYELNTNLRDAVRAFTDGVELRDGETAAAYRARYDYAPANAPPAIFYGDVSTSDVYFAGNLLDEAFGNITALWTNGTGQYALTAQEDNATFEAMVRAHMAGKMDFSRVVLMRTASDFDRAPHAEDDAVTAFLAEQGGFTPAIENIYVAGLPIVQGIIAGWESTFAPGIAPQDEWLYNANIFHDLVERKREVREFERMLKRQGAARLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5K1</accession>
    <name>A0A1E3J5K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031201.1">
        <property type="nucleotide sequence ID" value="XM_019176726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5K1"/>
    <dbReference type="GeneID" id="30193822"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="61603" checksum="FF2BC88ED4B2283B" modified="2017-01-18" version="1">MNAIQDSPPGRALPWGHQVSTPHSQRRAGLRSSQAQWRSSAWFITLVVTYGIAIDTLTDAIVVPILPFRLLDLGYHNIASDTGQLLFARSAGIVTFTLPVAYFFHKYPYRRLPLEVSVLVMIAANVLFMLSTQFWTMILARYISGAASTVALTVGLTLIGENVKEVKAGRHLGLAMSGLALGQSIAPIGTVLYEHLGWKAPFTFCIGALCLDLFLRLFVLERVNIRVFHEKRLGLKPDSLKPKLLNGKITTPVHHHIRDFSYAELNKAEREALLGIDLNPWQVLKAMVRSPRGMTAIMSMFTYGLLSGTLQPVITVRIQELWNKSSDTVGLVYFIATFPTLISGPIVGYGADRWGAEWVMLPSMLLVLPWPPLMLETGGIGAFVVFFLFINLFSNYAFYPSGLESTIIARRTQGISEIHQFGIMEVAFATATAVGTLVGGHVYDEVPSNAGWDAVMWFLFAIALLSLPMVFFFSGDVPWVKKIFSRKQPKIAGQSVCMQRLGDDNEDNAGGEKKRMDDKAEEAWLEMKAKMEDDQREYSKQKKKSDSSNPAFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J690</accession>
    <name>A0A1E3J690_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031626.1">
        <property type="nucleotide sequence ID" value="XM_019176216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J690"/>
    <dbReference type="GeneID" id="30193307"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130151" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="215" mass="21153" checksum="4124DD4768D2D93B" modified="2017-01-18" version="1">MFTSSLVALAIAATSVLGANHTVLVGQNSTKTFTPSELTAAVGDTVEFQFVGGNHTVTQSTFADPCTNSGFKSGFVPGNADSPVSFTISINDTTPLWMFCGQTGHCKAGMVMSINAPSTGKTFAAFQAAAVGNSSSTDSSSSSNSTETAPASSTETKNKNKGSSTASETASGTGGSSTASAAAASASSAAELQLGIPSVSGLLMAIAALAVGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6I7</accession>
    <name>A0A1E3J6I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031714.1">
        <property type="nucleotide sequence ID" value="XM_019176304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6I7"/>
    <dbReference type="GeneID" id="30193395"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34096" checksum="20B95BFB79F2F040" modified="2017-01-18" version="1">MPPKRPPPLPKSLFLGTGPLAPGSATLPPSPTTIHPSFIIDSHSFVTSHEPTPDPIYHGLKAEYPRPPVKHAVQVKMNVSAEPAQSVLGVKPFSIHPTILNLALATPPSVTNIAKGAVDIIVPSTVPLTEKDWDLLDEAVDALDGCWGHKEEGKEPRGRIVISGLLLPPLTTPSSFLIHSEAYNLHLSRLASLSLHSNVYLKALPPVVDAALLKKDGSPAWWTNRPELESVMRMYIAHAIETFGTHRIIFGSSSALPLYDLERVSHTVTELEQPISNGEWYSVLRKCVTELGEGLEETTGIFGENAKAVYDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6J1</accession>
    <name>A0A1E3J6J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031723.1">
        <property type="nucleotide sequence ID" value="XM_019176313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6J1"/>
    <dbReference type="GeneID" id="30193404"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="319"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="747" mass="83063" checksum="AD596898A4521E4D" modified="2017-01-18" version="1">MLEHGYMALTLLQLDPELDSDAYAGPVINRDSFDLNAYRRELSGRNIPSFPSHKPLDASKPGHYRTTETSFNNADTPESFLRRFYAELSPATSLNHVVDEKDHHNQISVAGSMKWMGIRDEHWRYHGRSSHIDLVATLSGLQRNTAGRHKEFVAEVIKTKRPEFWEVPEWEVVVAQEGVQSVDLGPWPDEGLSQSIINAYFRHINIHLPLLDKKDFQNQYDTGKWRVNKGFAKLCLLVFACGSRFVDDARVLWPVEHNKPVGLPHHSSQYTQRQSAGWGYFLSFLRTGKSIAEGPSLSEIQCQVLTCQFLFGAALPHYVWTLAGSGLRSTQELGIHMRATLHQADPVQREMFTRAFWCLYHLDRLNSSIIGRTVAIQDSDFDLYYPSDVSGSTSGESSEVSVFVQLIKLDHVLGAALQTIYAQRASLRSKAMLQVSVDQLNNALNAWSTHLPETLRWSPTIPDYVLFQQVSTLSLQYFYCRISANRPLMEPSAYAKADPSSAFALSLDASRRILDIVNSCLARSRQEPFQAGPVLDISTALPIWQAAIIVLIDVYSSSRQTTKQRDASLQLVRVAFDANQELEGQWKMAGKFNDMLSVLGDTEVLPSLEGGESAQNQLSNSRDHPAGRQAPFQSFANNAASTSSTRSTLANDAVPIPYAHSRNPSHTPPPRGGQFSGFLPQQFPIDPVLASQDEQHAALEHEPLGWLLAMSNPGAQGNGEIAGVNGAFGDGDVWAQLFDGGSFFCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8J3</accession>
    <name>A0A1E3J8J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031652.1">
        <property type="nucleotide sequence ID" value="XM_019176242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8J3"/>
    <dbReference type="GeneID" id="30193333"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN96406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="231" mass="24825" checksum="8DB329E9FD6C3F66" modified="2017-01-18" version="1">MAASTPAQSLEHRAQNAEQVGEHKLHGLVQEDADSTESGLRYGNCLSSSCQGHRASREPIHCIQQVQPNLSCPPTDLPTASDVGEAFRPVVPPWVVTAAYGVSWAYLIGDVSFTTYKSSQLGPSPLEAANVSEPTRLSMVAVKRTVFQGLASMALPAFTIHTAVRYAGRAFAKSGNVAARRWGPTVVGIGIVPALPYLFDHPVEQATDAVFDKLEESFFRGGPVPEPKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8S3</accession>
    <name>A0A1E3J8S3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031844.1">
        <property type="nucleotide sequence ID" value="XM_019175931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8S3"/>
    <dbReference type="GeneID" id="30193018"/>
    <dbReference type="OrthoDB" id="2564489at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="40949" checksum="EF030F90C559308B" modified="2017-01-18" version="1">MASSMTTQHTTAASRAKRLSTSATPSLVKRGSVIMMRDGVGDGDVPLEKECASLKKINDGLNKTNNSLRIRISELETLIEQATGPEVERLSEEVLTLEELLSVTQRQAGELSAMDNEAKLTENEKQKQYVKDLENLLGTLAGPSWRIDHQLSAPSVPTTNICSASTPLPKPKPKQLSSSLRHSVSFSSGPPASKLHRRANSTINLGSMMASVGAGAGLGAVEEMRESGGQDSTPTGALRRLNGGRSVSARPGTSATKELEEIRVPSSPPVSHKRAAEQTSGRDNGYVNTDQLNKVLHLLSTIDPTTISSLVGRELQDQHRPGRGEMNEVTKGDKDRSILEKMFEEQERRLAAREERLDRLVQIVRIEEARYDWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU5</accession>
    <name>A0A1E3JBU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032174.1">
        <property type="nucleotide sequence ID" value="XM_019175684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU5"/>
    <dbReference type="GeneID" id="30192769"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN98312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="24607" checksum="FE67EB8BEB96E516" modified="2017-01-18" version="1">MYKERAKKSRSVMLYTFGTVIIAIGVTYAAVPLYRAFCGATGFGGTPMTDSSRFTPDRLYVTPETADRKRITVHFQCQSAEALSWKFEPVTKSVKVLPGETALAFYKARNYGDKDLIGIATYNITPEKLAPYFAKVECFCFEEQKIRAGEEVDLPVFFFIDRDLVDEPALDNLDDVVLNYTFFRARRNDMGHAVPDAPEDVIQKSQGWENVPLAKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBX4</accession>
    <name>A0A1E3JBX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032204.1">
        <property type="nucleotide sequence ID" value="XM_019175714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBX4"/>
    <dbReference type="GeneID" id="30192799"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN98342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="9800" checksum="BE517219EF76BBE8" modified="2017-01-18" version="1">MALSTSTYPVDAVAVSPNAVIAPIASWDLAGEVAGLFCDVRRAVGLLPTSTKSAMVAKMAATAYRWVENVPTSDINFKINGGNIIGETDVMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC01</accession>
    <name>A0A1E3JC01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032272.1">
        <property type="nucleotide sequence ID" value="XM_019175782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC01"/>
    <dbReference type="GeneID" id="30192867"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58869" checksum="1FA643EB20F97360" modified="2017-01-18" version="1">MTAFNSHFVFGTTAAFSHVPPVISLALALLTSTPDLVISILLHKNNEENSLSIIEGTPQDVVSRLKLVLIGEKTEWNSVSLSYIQMMELSGGEYAKILAASLSITDCAPWPTPTVFIGDYTSFFFIPVKTKVEENFPHLKPAKFIGYNPQMAAEALLCDGAEENGSLRWVDKALAEFDSEAVVSLQANQLLNGKTKSGDDKIMPPEEQAARMIKAYRACVTESKHVVKIPGWTPFHVSELWSLKIDWTQMNELAWFQWLSGRQAMAQVPEAWISCFPSSVFEPETIAAARKDEYITNGGKKPYFEVGWFERKPKANWGEGVKEFLDKYEAKSVVYISFGTVVNAGFGLPVIFDYLEQTKTPYIYACGNQYDSLPQHVKDTLAKSQAQGFCIAPNWVDQVGILSHKSVKAFVSHCGVNSALEGILAGVPIVSWGRRGDQVLLASIIHHKGLGVELLQHREGSTIGHATAHRPEVTVTGKPEDLKAELAAAFEKIGGPEGDKMREKANALATEIRAKRTGDWEETIKLFGQFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC24</accession>
    <name>A0A1E3JC24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032254.1">
        <property type="nucleotide sequence ID" value="XM_019175764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC24"/>
    <dbReference type="GeneID" id="30192849"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="306" mass="33876" checksum="4A6BACBED639C4C9" modified="2017-01-18" version="1">MSPPLVTIYTTSLTSAPTVRKHHDLLRSSLKGWEIKYVEHDLVMEEDAKRRWQRAKPTGKVIGLPGYLVGGEWIGTMDDFEDAVETQSLVQFLKQDLDIPDEPAPASGAAPGTAPKQKSIQEVELEKLMGEMTNDDLDKLMQDLDVGEDAGTMGLRHQVQAEAKKSEEAKPEKEEEKLERRPEEEEKPLEAKKGETEEKETNRLAIESTRKADPKQVSSGKSGYSLEGIIVDAITGKETAGLSVKPAEEHEEDDKEDPAPLTTKDVESVGTTRGEGRRTVVDEIKEANELEDKEEADITVAKSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC96</accession>
    <name>A0A1E3JC96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032339.1">
        <property type="nucleotide sequence ID" value="XM_019175849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC96"/>
    <dbReference type="GeneID" id="30192935"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN98477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="48487" checksum="B34B29E597F5C72E" modified="2017-01-18" version="1">MEEIGIDLKIEDPTLTAQASEKQILLDSLPSGSEELYSTWKRLEAHREFLQLQEEYIRDETANLRRELLRAQEEVKRIQSVPLVIGQFLEPVDERRAIVASTTGQNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSIAMLGADEKPDVKYSDIGGLDAQKQEIREAVELPLIQMDLYRKIGIDPPRGVLLYGPPGTGKTMLVKAVANATKASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPCIIFIDEVDAIATKRFDAQTGSDREVQRILLELLNQMDGFDQQTTVKVIMATNRADTLDPALLRPGRLDRKIEMPHPSRRERRLIFQTVTSKMNLGPDVDLEDYVSRPDSLSSAQIASICQAAGLQAVRKNRYVILPVDFEEAWKSVVKKSDETHEFCKYRLSLDATEFALTILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF53</accession>
    <name>A0A1E3JF53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032539.1">
        <property type="nucleotide sequence ID" value="XM_019175436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192519"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1456"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1554" mass="172536" checksum="CB9E037C790B54DC" modified="2017-01-18" version="1">MSGGNIKVVVRCRPLNSREIARGAKELITMEGNQTIIQPPDVAAVSARAIGKKPMTFSFDKSYWSAGPKTDPHYASQQTLYEDLGADLLDHSFEGFNTCIFAYGQTGSGKSYSMMGYGPEKGIIPLTTSELFRRVDERTANDSNLSYTVEVSYIEIYNEKVRDLLNPKNKGNLRVREHPALGPYVEDLSRLVVENFGQMMTLMDEGNKARTVASTNMNETSSRSHAVFTLILTQKRLDAQTKMTGEKVSKISLVDLAGSERQGSTGATGTRLKEGANINKSLTTLGKVIAALAAGSTGGKRKKEDHVPYRDSVLTWLLKESLGGNSKTAMIAAISPADYEETLSTLRYADAAKKIKTHAIVNEDPNAKVIRELKEELELLRSRVSTGGGVASDEAAYDPSIPPEKQIVTYRTKEGEVRKVTKLELQDQLEASEKIMESLNLTWEQKLSKTQAIHVEREKALEEMGISIDKNMVGVHAPQRNPSLVNLNEDPLMSECLIYQIKPGKTVAGAVDDDKAHIKLSGTHILPEHCIFVNEDGVVTIEAMPDARTFVNGKRVPPKARVRLLNAFRVILGDSHVFRFNDPQAVRAERQKLRQSASVDGLSNTPGARPDSPSVKADVELMDWSAARREVADIEKLGDQDLDKLYDDILKVRTQRKRPESRADFGDFDIDRSADPSSNPWAAPGHSLTVTSNSLGTPVGQEVDVHIYDECSEASTEQPFGLSTPASPAPGYQDQKSADVKLHQDHLTRQLKLMAQEVKRVRSEAARARALETVDMEPESWGVEELRKVRRVLERWEKLRGYRMAEEILTGAVDLREANVIAKQMGKQVTYNFLVVDGSLASPASSLDDSNALVEFDDVSNSVTHYKNGPVVAVKVIDWEAKAAYTWDLPKFKQQLVRMRQVSALKQKPNYSEHFQIDGLFTDTPPPSFSFVGVAKVPLRLIASQLSYSVTVPIMCQYTMEAIGSCRVAFRCGNPDSSSTSGIDTPDPFSHISDNLLSVGSKFTFTLIVDTVKGLSSTDYASIHAQTRLSSLVGPSIASEDTFASQAVDLDKASGTHLVLKKTVSVMVTLDILRFLREEYATIGFFAKAKHGYLERLERWDINHGTAPGSHLETPTQNGVTKPAMRRCETDFVVPERHDVLATVSILELSANGDYTSAEVFDDTFQLHQGLQRRLQLRLNHASGKSFPWTKLEHASIGDVRLMTKTGAASVGKSQVDVKVSDETVEYHTDGTSTLEAEGVFDTASLACRHLDKRTPSDQHLVIKFTWLLDVSTLSEPAVFHLDLPIRILGRDARRSSIMTFFSAARAFESITRVYSVECAPPLARSANELWRLDTSEKHVKGEESLGRWKPRSLDLLDDWRKMRKAQNGLGEVAITKVVLEMHGEEMDGGKGHGGNTELLERSLMLWNKAMSERVKVDITRQGSEEEAVARKLRKLLPDLETKPVPTVKLEPNIDNVIKYGPLLLLRDSTSDRWEKLHFVLRRPYLHVHQSAGQRELQVINLTGCHVTTSPEVEMLLERRWAFTVFTSTNSYILQASSEKERKEWMSVIGTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF86</accession>
    <name>A0A1E3JF86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032581.1">
        <property type="nucleotide sequence ID" value="XM_019175478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF86"/>
    <dbReference type="GeneID" id="30192561"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN99504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="79" mass="8993" checksum="7413002E7FA6954D" modified="2017-01-18" version="1">MNTDSYRVKITSGVLVTCDSAAKQILLHLDSLRDGNNKFVALDWGDENKVLIKKDYVEHVKEALQDELEKNTYVQDPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHV7</accession>
    <name>A0A1E3JHV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette, subfamily D (ALD), peroxisomal long-chain fatty acid import protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032578.1">
        <property type="nucleotide sequence ID" value="XM_019175475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHV7"/>
    <dbReference type="GeneID" id="30192558"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130371" evidence="9">
        <location>
            <begin position="29"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="514"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN99501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="831" mass="91803" checksum="F512408CF908768A" modified="2017-01-18" version="1">MSPPQISRTGQYSLLVLVLALVLARSDALDAPAGILNGWRDERKRRRQERKRREAETPLNTPALEKRLVDLYSPDPSSDSRTLLVPHMGRISKVQITPTSKELYKEHLPLFPRLKAGERLGVNKNFWRMLGAVLKVAFANRGGKEAFLLLLHTFFLVSRTVLSVMVARLDGRIVRDLISANGAGFLRGLGWWFALAVPSTYTNAMIRYLERKLALAFRTNLTRYIHDLYLNENLNYYKLGTGVGASTGTADQFITTDVAKFCDSLAALYGNIGKPTLDMIIFTSQLSASLGPLGTIGLFANYGLTAYILRSATPAFGRMAATTARLEGQYRAGLARIGRDGEEVAFYNGGKREKGILVGMFEALKKHVHSVFKARIPYGMTEDFVIKYLWSAAGYGLMSIPIFFPGATKALSTGGSKPHAHHAIAERTESYMSNRRLLLSLADAGGRLMYSGKDLAELSGYTSRVYSLLAELHGLDNGIYAAQARPDDLPADQPFYDMARVEGVTSIGPDHILLRGVPIVAPAEGAGAERGGEELIRSLDIRVEKAEHTLITGPNGSGKTSVARIIAQLWPVWKGLLERPVQGEGGIFFLPQRPYLSIGSLRDQVTYPHTYAEMKAHGRTETELMGILKAVHLEYLPGREGGWETRKEWKDVLSGGEKQRMGMARLFYHRPSFAILDECTSAVSSDVEGLMYEHAKDLGITLVTISHRPGLLKYHNRHLRLGDPGAPQPSRLASRAPSRHQSSLHLPLAPSTLHLTSLTSSLPSPYAELPQTPLVEKGWQFTVMSSGTDKEKLELDKEIEMLESILEKEVGEWEKRLGDINGELKGQVNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIQ9</accession>
    <name>A0A1E3JIQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MRP family ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032930.1">
        <property type="nucleotide sequence ID" value="XM_019175198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIQ9"/>
    <dbReference type="GeneID" id="30192277"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003849">
        <property type="entry name" value="MRP family ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="340" mass="36117" checksum="D398DDF79885960C" modified="2017-01-18" version="1">MFSPRAAVLLRPLAACRQLHVSARACSHENPLGIPRREANPAPTIPRRGAPPQKSRIKGVKQVVVVASGKGGVGKSTVAANLALSLLNSSPLGRAPRIGLLDLDIFGPSVPKLMGLENAGDPRLSDENKLLPLQNHGVKTMSIGYLLPPNPENDSPVVWRGMMVMKAVQQLLFDVDWTSASAIGKDDLDVLVIDMPPGTGDVQLSLGQLVSVDGAVIVSTPQDVALIDARKGVGMFNKVSIPMIGLLLNMSHFTCSSCSTPHELFGSAAKFEKAANDLRLEVLGKLPLVTSVSDGGDAGRPVMVQSSETGEEVRRTMSQVGEKVWRWLLDHTPASLGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLC4</accession>
    <name>A0A1E3JLC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032924.1">
        <property type="nucleotide sequence ID" value="XM_019175192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLC4"/>
    <dbReference type="GeneID" id="30192271"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="147" mass="15384" checksum="D5213D64DAB6ADF8" modified="2017-01-18" version="1">MNPGAGPFLNAQLSPDFSPLHPQSVIHNTRILGSISTLSACFSGLVAGILGFTNSHGFLLYLISSFVTALIVGTIKCGADLQRFVPGAQPQGKKAVSSAVNTGPSTEDGGLGASLKGWWSLSGIGQENFLGFLLFWIGSYALIHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLZ1</accession>
    <name>A0A1E3JLZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033130.1">
        <property type="nucleotide sequence ID" value="XM_019174751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLZ1"/>
    <dbReference type="GeneID" id="30191819"/>
    <dbReference type="OrthoDB" id="10326414at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="279" mass="31718" checksum="0E2A4A088D0E0831" modified="2017-01-18" version="1">MSTPLTPIPFSTPKRASEDDDEKPQKVSPVQRKTSDGRVLYKGWSDDSLDTLIVSSDDKGFYIEGCMLEGHSTVFRDIFSVQAATSPPQTPVSPSSSGSPHPRLLELTDTTFEDSQTISSVLFILEDAQYTLSRLIAFAGVRTVPILHHVLLFAQKWDIRFITSRLHEWICEVAIESHRAPYNKFSQYDLLKLAMLADLPYAGYTVIGSWSPPVALTVTYGFWRERSEDALDIMKWTKKAWAEWTPEWLYAFSTLQSTRRGMNRSVLLLSSNTSHRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMF4</accession>
    <name>A0A1E3JMF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033297.1">
        <property type="nucleotide sequence ID" value="XM_019174918.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191989"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000825">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="894"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="911"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO02045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1535" mass="168520" checksum="3EC86E20BAC744A5" modified="2017-01-18" version="1">MARAQLTRSRSTALDSYVAELGNDISYDKSLSSSRFLKTILARHKYGPIVLKIFIKPDSAMSLRVIQRRLKTERDALTSLPNVNTYQTFVETEKAGYLIRQWIGSNLYDRVSQQPYLAGIEKKWIAFQLLTALRDARNRKASALRPSVAHGDVKSENILLTTSLTVLLTDFSASFKPTFLPLDDPSDFSFFFDTSGRRTCYIAPERFYTSTSRVADKKRASEADAKGDVFGKRDGRVTEEMDVFSAGCVLAEMWTDGRTVFNLSELYAYKDGSLGLEGILDHIEDGPVRDMISQMLARDPPKRPSFDLILSTFREIIFPEYFYTFLEDYFNTLNEVAEASSVGAHADVGFPQRSAGQSGTKVDKIWDEWESISTYLGAGPSDNGPALLILNMITSSVRHCLFPSSRLHALKLFVNLLPFLLDEDKVDRVIPYIVELLSDDIAVVRAEACQTLVEVVDNVETITPQNATFIPEYLLPQMRHLATDNDTFVRASYATGLVKLANAAVNMLEMSQAAKGSVSAHGTEASVIPDYDSMLLEIQSVVEEQATTLLVDPSPYVKRAMLSSISDLCLFFGRQKSNETVLSHIMTYLNDKDWMLRLAFFDGIVGVGAFIGLRAVEEYVLPLMFQALADPEEAVVARVLYSMASLASLGLLARMRLWDVFFAVKGFLFHPNTWIRQGAVDFIATASRNLPISDVWCVLYPNVRPMLHSDISDMTEASIVSALLPPLPRGTLTAAKAAALQNTPAGFWQVTPVTLSTKVDLMKSAQKPSQKQGKLQDRGISATDEVKIEAMKEFIVKQAYAARAREGADRPTVPEVDLASAKSVSLTDLGVTPQTVFISPRTVGVDSRDDLRRLPSQTGIAGSRRTSFASKSNRGPVENPLEEIRKKLAALEPISRPETPQPPGEPPHSYVDSNASPSESGLSSTLDIAGMTRNSKRKVDSKAAPAIGASRTNAVGMTTIHDDPMSGRTTPNAAAMPQLGTGGASTPKATAPYASSYEGHDPGVRAFLEQIDLDNYREPLLDFGPKVTASHKKRSARVKSSSSSPQGVTMIAHLTHHEQAITSIVTSPDSVFFATSSEDCQILIWDTARLERSVTTKPRQVYRMDAPISTMCRIENTHCLAAASEDGQLHVLRVHVSGGSGGANARYEKVERIRSWRAQESQGHVKHVSYLSGELHLLFDSIITDATTDSSLLLITSTFLIAILDIRSMSISKSYQHPLDLGIITAVCPATHWLVLGTSTGVLSLWDLRFGLLIKSWAAGGAVTACKIHPARGRDRWIMVSVAPSTSFMPSPSADADRPDEAVSRPLVEVYDLETSRLVEVYEVRSRRPGKNFDPAPDPQEVTPDRASLIAELAKSPPSLPSPKTVDDFDASTPLPASPRTISDLIVGQSWASLPKAEDNMLMSVPEIGAAGKERDLSGRQGWMISAGEDRAVRYWDLVKVQGGFVVCGSQKEKDVTFRQTADAARPTMFYTLPNVHRQGQPIPRDKEKQVLRPHYDAIAKLGTLETPFSSCVISGDRSGVVKVWRMEGAPTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JML0</accession>
    <name>A0A1E3JML0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02829</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033350.1">
        <property type="nucleotide sequence ID" value="XM_019174971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JML0"/>
    <dbReference type="GeneID" id="30192042"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="34"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="417"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="574" mass="65379" checksum="6556E0D67F0E7A19" modified="2017-01-18" version="1">MASPLRSISRCPKWLGSRLCHSHAAPEANPVNARLRFAPSPTGHLHLGGLRTALFNHLLARKWKGKWLLRIEDTDRTRYQEGAVDSLRSALDWAGLDYDEGVGAGGSHGPYTQSERLDIYQHYSKQLVAKGEAYECFCTPTQLEAIKMSLKKQGLMHSYDGRCRHLTEEDVARRKKAGHTYVVRYKNESGKLDLPADMIYGDRQPTAVIGPDDFVLMKSDGWPTYHLASVVDDHLMEITHVLRGEEWLASVPKHHRLYTAFGWTPPRFAHLPLLCNPDGTKLSKRKGDTFVEHYIRRGYEPDALLNFLALMGWDYQSIISPSFDPQETPLDPHVRSDGHSLHELFSLTQLIESFDPSYITHRKASVDQGKLDFLNKMTLRRKAGRLGADGSMINALNKEGNSEKEKRALVQRFQTMLKEEKALRGCVRVDDLGYVEKVLEADLPRTVILKDMPLQSIFYFLPPTYTCQESQLILKTINPRLYCQYIGLFAETLQHYADKAVTVDSDLVWDVIHKVIDELHIAKKPQLLVPLRHALTERKKGPGVPELVSVLGLEESLSRLRRAEDFVRERLEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPF3</accession>
    <name>A0A1E3JPF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033044.1">
        <property type="nucleotide sequence ID" value="XM_019174665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPF3"/>
    <dbReference type="GeneID" id="30191730"/>
    <dbReference type="OrthoDB" id="2576314at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="611" mass="61443" checksum="90ADD972D660DFCB" modified="2017-01-18" version="1">MLTTEIGIAPIPIHIAYADPERVLILRRSVPLPVERSQGSVSALVARFQTAANRDQEAATRDTSRRTSLGPTATAGLTSPILSAAGGAGGVSGMTGGGLGGLGGFGRKGEEGGQVAGSPGGEQGEREESPGGASVAPAPSPAKVPVPSPAKPAEKGTTIPSPSPSTNEKPTRPRNSTPSSSPAPAHAQSTSSNKPSARGALGRSQSVKQPSTSTKRLTPSHTGATSRTVSSPASHLLSPPQKPRDKSTSPAPLNPQLTGTPSKPTASFLAKARSPPTRAASAMGAGVEGRKSSVGSREGAKSPRSSLGRSSGAAVRPRTSASDRPAGGAVKSPEGQEEREKKSSVGSSSGSRLMQGTAASRARAAANAVNAAGASPPSKVKSPPAKARPRVSNGNPHPPSGPSPKDGTSAAKSSATRPSPSTSASASASASASASDSASDSKTARGESADKPKAPQAPGRMVAKPRLGLAAARERKTSDENGDRDGRKPGKKEEEGRAPASNSSDRQEDKRPVSPSPTPSSPAMNSSTSAPTPPTSSPEADDVSPTKIVGDGHEELGEKDGEVDVGVEDGEQDGARVVGGFDEDRKEESKLDEEKDGGGDGEEELDEIPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRI9</accession>
    <name>A0A1E3JRI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033549.1">
        <property type="nucleotide sequence ID" value="XM_019174497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRI9"/>
    <dbReference type="GeneID" id="30191558"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="407"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="80691" checksum="9E88080E0AC0452F" modified="2017-01-18" version="1">MAHLPGAQQRRPIANLPHQHQRPQPPASRVTPYTPDNRELYAGPRNRLFLALRSSIPSEVDWALPRLVVASFDAPDSFKLDSWVDSVGALKEWPTKWLEGLEKEAAAFELRQGRLDFADVKGEDRSAKRLKRDLVLSTMPEWLSDPAVEKRATNSLLILRNASFSGPNAKTICKEPFLAFLNDFFSLPIPFLQHLLLRSPEPVHHIFATIQSIFPAMNTEIPGIRRIFGEVFPRLLIESSDIAVANDVLPILIMGQTIPNITYPPELVPYLLRLLALRPPGATLDLVLDLITAFTLNPVYARQILCDPNFMQHLKSLAVLLDHNGQNLSILYDGVPYMRAKAVLNPAGGAYKADESSKRRTLEREWAQKTIDPLSGRGLAMEVGTEPPVLSDAAKKRLFAMKEPQRSIAWMHEIFVYSSTAQVLQVTFWHAYRDFFSGPGSHEPLLSASEVIKNVTAAFPTAAAKVWNDAMGNQKFVIAGVGFRKGSDDSERFGCFWRDCAHREGATNPAQLIEHIQSFHVPPSTYTPCQWGSCTHAPCTLSHFLTHIPLGKPITQVPDYLSCYAGTSPDWFSRQVVTARLPPPTISRMSFAGRKTATDANRRPVGTPLLAALTVRNLARTLRTEITLALPEDVPTEDEVQAKKKHLLEERYGLPIPESVIKEEEKEQEEANQGAAGKEMNMSDEERERAKAAFESIEEKVERIMEENVGNIGHYLGDAFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRL0</accession>
    <name>A0A1E3JRL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_02347</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033551.1">
        <property type="nucleotide sequence ID" value="XM_019174499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRL0"/>
    <dbReference type="GeneID" id="30191560"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="60"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="283"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="640"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO03500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="803" mass="88649" checksum="1D666BD2677E5A03" modified="2017-01-18" version="1">MAAPTPSWALADNQTADPKDKSAGPGAQWRALNVGPDLIRSLLVRKFKSPTPIQRASIPTALSTPPRDILGMARTGSGKTLAYMIPLLQRTGAAHRSQGPRALILCPSRELAMQIYTVGKDLVRGMSKKGKGKKKVDEDEEMAEDDEAKQALRWAVIIGGEGMDAQFSKMSSEPDIIIATPGRFLHLIVEMKMDLRHLQTVIYDEADRLFEMGFDVQLREILHRLPSTRQNLLFSATLPTSVAEFAKAGLVNPLLVRLDSERKISEDLSLKFFAVKPTEKEAALLVLLREVLGKPNQPQMSETNASPQAIVFVATKHHVDYVAELLRITGYRTSLIYSSLDQVARQQQLAGFRSHKSDVLVVTDVAARGLDIPIMDHVINYDFPAGARIFIHRVGRTARAGRKGTAYSLVVKEDYPYFCDLHAFIGAERLGEAQYTLRSMPTELLSENVEYVFSSLEEIAPHLSALRGVMKKGQGMFERSRTKANPISYRASKALSTALSARGGARLDGMFENAMEDEVNEEKARLLKQVAEFTPDWTVFEVGKRESESAIIMQKRRKTVDEKKKRASKAEADQAAASGIERAVKAKERRRAAVLPQLPEKDWKDPSFFLDHTRSGADEEKGYSLKTGADVPTNLNNAVTDFTADEGAGPRAQKASQLSWDRKKHKFIQKSGSAEGVKMIKSESGALLPATYSSGKYKEWQKKRKNVVDGPVDPLSGAVGGQGRKGKHGPVGVKRKDREEGDGEESGPRGKGGRDGDRPGKPGKKGGVKQSSGIRSAEDIRKHRATMAKRKEKNARKPHKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRL5</accession>
    <name>A0A1E3JRL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033555.1">
        <property type="nucleotide sequence ID" value="XM_019174503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRL5"/>
    <dbReference type="GeneID" id="30191564"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="31062" checksum="5D021B311D557A92" modified="2017-01-18" version="1">MAPTPRLRLENKVAIITGAGSGIGLETALQFASEGASLVISDINLPGVQAAAELINKHYPTSGTVAVKCDVSKEPEVKAMIDKAVEVFGRLDVLFNNAGIMHPADDDAIATEEKIWDLTQAINVKGVWYGCKYAIQAMRNNKEEPEKGLSTGGSIINVASFVAILGAATPQLAYTASKGAVLAMTRELAMVHARENIRLNALCPGPIRTPLLMDFLNTPERLNRRMVHVPMGRFGEAVEQAKAVVFLASDDSSYINGTDFMVDGGLHKCYVTPDGEPSQAGPTGLLATLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRU8</accession>
    <name>A0A1E3JRU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033659.1">
        <property type="nucleotide sequence ID" value="XM_019174607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRU8"/>
    <dbReference type="GeneID" id="30191671"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130510" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="849"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117960" checksum="0DED2603699D56EF" modified="2017-01-18" version="1">MRLITLLSLGSLGLKQALALGDPQVVYFPTTDQLSAREYSYLPSHHSQQAAFDYPSSDKAEDGFILAAAHHRYTAPLLLSSKEDQAIHRAARTFVDDVFKVTGHRPDIYNDTLPSNVERAIIVGSLKSPIIVRELRAQEGVRAELDGKWESYDIRCLLSPLQGLEESLVLTGSDKRGTIYALYALSAQFGISPFHFFSDVPYPQHSIIAFDKSQVLSHGEPTVKYRGLFINDEHPALWGWAMEHWSKERWEPALVVEFYEKWFEMMLRLNANYFWPAMWASQFYSDGLPPNSSASTPGPNLLLAASFGLVPGTSHHEPMGRNKPEWDASHHGAWDWTENKQEMEEFWRAGAERGAEAGADIVYTMGMRGDGDEPLQGASNALVQNITSVQQEILKDVYKTDDLESKGVGQVWCMYKEVAGYYQSGLEVPDDVTALFADDNYGNIVSVLPPEREGHKAGAGIYYHLDSWDQMNIARAFNTTQIWIVNIGTLKPLEQPTEWFLDLAWDSERWPRGSWREWREQWAKREFGVGEEVGREVGDILGRYELLASRRKAELVDAETWSIINYNEAEIVLAEWTSLTERATKVYDHLPEERRAAFFELVLMLCAAQANLNKLHIAVARSKLYAYQARTAANVFAREAIDAFHQDANITETFHALLDRKWDHMWDQSHINYYEALEPVRDSLPPIHFVNPNQPVFPGIPLRPQDFPGQVAHMRVTVENSFGAWPGNTFLNCPQMLHCADPTLKTLDPWGEEKRWVDIGAGGPRDVEWTAEGSDEWVIVHPKRGKTKRDGSADERVWISIDWDNVPRNLEGKSVRLESRVEIKGNDYTNVTVTIPIFIPSDIPSSFSGHVEGDGYVVIEAPHFSRNSSSSGYAFEVLEGYGRTLGGMEVFPATTHNFSLDKGPKLEYDFWTHEGGVKDGEDVEITVQLGPTLNFLQGRELAFGLQLDDFPPREIHPIPTKHLGESDQSKVGSVPADWMESVSQEIRNVTMKVERDEGWESGEHTMTIWGMTAGIVVERIWVDLGGIRDRGYSYLGPPESKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRY1</accession>
    <name>A0A1E3JRY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033690.1">
        <property type="nucleotide sequence ID" value="XM_019174638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRY1"/>
    <dbReference type="GeneID" id="30191703"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="194" mass="21528" checksum="DDA7B4977F17DB4B" modified="2017-01-18" version="1">MLSYFEPPEEEHCYICFRLFLTQTASPPSPAAPLPTQPKSGNSPSQYRLSQTGLGLKRMKRTMSAEWDFSFLMRIRIKTTKSMERLATEGSFRSTSTFPSSIKFSRRRDNTAERAGPGGKTGAGGVWSKGGGDFRGFKVGLVKKGNSRTILRLLLSPFSRPHLLDTFILISLSPSDDVRNALQPLPTAFNGRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW87</accession>
    <name>A0A1E3JW87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033776.1">
        <property type="nucleotide sequence ID" value="XM_019173969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW87"/>
    <dbReference type="GeneID" id="30191022"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130627" evidence="1">
        <location>
            <begin position="24"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="360"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="70359" checksum="30412A0CE7056ADC" modified="2017-01-18" version="1">MRSRISLPLGVTLFAFTATAYQSAPQDLPVPTRQLEWKDANFLSISDSHGWLLGHQHATWPEPNYSGDYGTFASFVSHMRRIAEEKEVDLLLVDAGDHHDGSGLVSSSATSASSAEDIFSLLSYDIITCGNHELYKYKDAYEEWENQERWHGRYVTSNVNITIPKGDAFESVPLGKTHLKFTTKLGRKVTAFGVIFDCRGITVQKPSKVVEEEWFQDVITEAPDYFVVAGHMPVRGETGEFMTVFDAIRKKHPKVPVYFFGGHTHVRDCVQYDDRAIGVVPGRYLESVAFTSSSLPSYNDDGKPLDVARRYLDANPVSRWHTNTTDDTFNLDIGRRIQVALARLSSSLKITKLYGLAPHDYFLTRHPWGHPRSVATLFSDKVIPDILEDKERGRGQKGDVGGERLVVGNAGSLRFDLFQGRFDRNDELTVSPFGTTFLYTRLPAGLARNITDQMNRNGASKLVPSLTPSTPVEEEARVQRIYEDWMREQSLDYELQQEETRLRTVGRGDQAVLGLEGVSQVKPRTLGFVTKDKCPGKGDDIEHIPVPFYEAQPDFVSSPFPEDMPDDQEMDVVCMDFALDDFLTAVNTLDPTINLQPSHMKPYAEGLTIQDVFGKYAEKHWRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWL7</accession>
    <name>A0A1E3JWL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033791.1">
        <property type="nucleotide sequence ID" value="XM_019173984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWL7"/>
    <dbReference type="GeneID" id="30191037"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="38"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="615"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="707" mass="76272" checksum="CC2D17869F18F8AB" modified="2017-01-18" version="1">MPSAPIATPPEEVMNPADEEFYASWGLCILCVLLIGALCTSYYLQIKRIRAVHETVVSIFAGMVVGLIIRLSPGHMIREMMSFKHTFFFNVLLPPIILNSGYELKQENFFRNFATILTFAFLGTFISAVGIGVLVYIWSFLGLEGLKFTLLECLIFGSTLSATDPVTILAIFNTAKVDPKLYSIIFGESILNDAVSIVMYETLSQFHGEDIYISSIFHGVGIFLFSFITSMALGVAFGLVCSLGLKHSHLATYPHIESCIVTLVAYTSYFFSNGVTMSGIVSLLFCGITLKHYAYHTMSRRTQKTTKYMFGVLAQLSENFIFIYLGLSLFTQDVQVFKPLFILVSAIAVMASRYAAVFPLSELINWVFHTRGQRAEELPHSYQMMLFWAGLRGAVGVALAAGITGDNADALRTTILVVVVLTVIVFGGTTSRMLEVLGIRVGVEDEDASSDEEEGWNAYGGHGGLALQNGPGSRQYAGQNGRAGWDNPSEIDLHSPGDSPYSQSLKLSGQDARSRQSSRGYGVRSGFSTNSEESDEGEVLPAAGPSGYAQNAYDAEANTPTSDAPGGPGMIFRDGQWFTALDERYLLPLFSNSVTARRHNAKKAVKRGTAAAAAGAAGSASGGGSGAGTPRGVSFEMADEGYGGDMENEMGKNKALPRTFSGSVSDFFFSKPDSPVSSGTSPSLPLDERDPRRSLGRDQKSAGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX41</accession>
    <name>A0A1E3JX41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Pre-mRNA-splicing factor CWC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_02131</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034093.1">
        <property type="nucleotide sequence ID" value="XM_019174286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX41"/>
    <dbReference type="GeneID" id="30191344"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODO05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="351" mass="39067" checksum="1D6FA9992A7D2FB3" modified="2017-01-18" version="1">MSSSTAVAPKRKLKPARKQVAADEVDKSEGYQAGREYNVWYNKWAGGDREDALANKVHSQTRCVISRDSGYTRADATGNKFCCLFFARGCCPYGYECQYLHRLPLPSHQLADHSRDCFGREKHADYRDDMGGVGTFNRQNRTLYIGKIAEHPDKKQMEETLLRHFGEFGKIVKWNILYGRGVGFVTFETDHQASFAKEAMANQSMDGDEILNVRWATEDPNPGEKVAEAQRIEEIGQKAIAGMLDDELVEATQTIRALEDGDVEDLYEIEASADHAQNGEGGEGEGEGEEGRPAKRGKTDGFFGADALDNIKFYADLARKQAEERVKERKVPEKKVGMALLGGYGSGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX46</accession>
    <name>A0A1E3JX46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034084.1">
        <property type="nucleotide sequence ID" value="XM_019174277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX46"/>
    <dbReference type="GeneID" id="30191335"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="586" mass="64448" checksum="BF6613060BD11D52" modified="2017-01-18" version="1">MDDEHNAYEIERQKTIAENRALLDSLGLDPSSRSPFPSSSPAPTSHPNKSKPAKPAAAKKRKAPDSAPADDDGPRRRSGRLRGMEADGEEMKVKLEEEEREREVLRVVNRREREQVMGVGSMVEEGTEGEVKELESFLKDKSALENPRPYPSGKESDSDAYADSSTTSDDTQRLREAFSDMSLKANVKVTNERVFSMCVHPEKRKTIVFVGDKYGGLGIWDALGPAAAKAENDDDTNGVKDEEESQEGRVWRIQAHAKNSISCMKVDPVNGSGLFTSAYDCSLRHLDFSTLQSTELFRLPDEDLLINHFDLVPSGQEAWMVDKNGGLSHCDFRQKHNQSGRKRWVLQDEGRGAKLGGVSVNPAMPHLICTAGNDQHVRIWDTRLLADIPFAATTIDESKPPTPPPSALLRTEPVGVSDYDAVSTFMGTKPGKGLMRGKWQHGKSCSSAYWDPWGRRLLTTSYDDTLRLFNLSPSTLSSPTPIPSSLLKPTKSIRHNCQTGRWLTILRAQWSTSLSAPPHFTVGNMKRTLDVVSGVSGERVVALWAEGVTAVPSVTASHPGVVDRVVGGNTSGRVQLWSSGDGIYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JY82</accession>
    <name>A0A1E3JY82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033822.1">
        <property type="nucleotide sequence ID" value="XM_019174015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191068"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="194"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1628"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1866"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1902"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1962" mass="209139" checksum="2D48130DA34F5DDB" modified="2017-01-18" version="1">MVSILSFFSGKKKPKGHTARPPSPTSPARDTPERPAARFLSLRQKATTNPHGTSSRRASSELSRKRSQLQSGGSSPPIQLPKLDLGLEVSALGSPGDTALDIGSMGRPPNLKQEERDMLRELRWDVGEVKLAWEWFGSALKATGLDTRGILLPRGIDADPTTHFYLFALFALYTKPHLIDSLPSVASHLAKPTSERPSEIWHERLVTSLRDTDKPLDISEGLKFILRRLLPSATGEDPLISRQVYTTFVQAEHASSYPLSAFGEFLGPNVPAEVASYLHEMFETWAAIATHADQNTLTGGRLAYLLGWWAYGMNAGKVASFDHFYKTWKEAGKRLEHLLYAWIRFQSTKQRLPMRMLQLVNDYPFGEASASSEHLPLPPPSSSSRKTLHVVLKSSLPVNKAGSGPEEIIHAALRATIHSEVSAPQWSALTKDKVNPADIVSEDSLSLFKTLAPSEEPLSPASVLDLPSAQEPPIYRPFQTHSRGHSVLSGHSTSSKTRVEGEGSPDPGAWDDFEKIGFSETGEGTGDLKLDFSAAASTGPSGKSVTSPTQKRKSAEKPLNKSRKTTFRDSTELVPTFTVMSEAVIKIDDIFMSFFEDAKLDDVTASWPPFSLVRLSSPIDQPKPIEWLLVSIEHIPKPPSEPSEPEIIERPTSPSARSTASGRGSNSKGLRDFATSLSRRKSSAGGGNGNSARRSFFGIPRSGSGLKEGDLPTLEELGKKKPEPVSIGEMGEIVSPSRSQSAKNLASPLTASRIPIANKEVDNVSTRALFVPTPAGTVQNSPLPSPMPTASGFEEGTSLLGAISHDGGDKGADDKALDVQTTAAPHAVKVVPSATEPTKNLAEAESSDDEELPAPRRGERSLAPSPSLPPTIREPEIEEELPAEKGADQSSVTPETQSVKDEPVDQENGEGITGLLASGTSAIAAGGAAAIAAVAAAADLVLSDPEHPASSTPDQPQEDPVTEIRSQDASSQSGTLDVDRQREPPQQVMVADEETPLSKTDLQLEEERQNEERGAGVSSLKGAKAAGIALDIQPHQSEDHPAPVALSRTSEDKEQAVEAQPHTHLEGVDAEGHPFPPRQIMVANEEAPLPKSDGQLEEERQAERRGMSLGGIEGATAAGIALDFQSENQDLHSIDDQSPPHEDKLDSEESSLTAASTSASASTIEERDTETSYTQHIQESSEERHPIEVTVETVATGTPGTEKNFHFQPVETPAQTPALRDSEDATAGTDEPAVPSTDTIDREQVTTFEPAAQIVIANDVSKATEKDDLPPTGVDDRLIEQEAMSAQLATSEVVLAEPMGIETPIDNIGSVLAAGVTGSGLPEVTKAFGNSRVRDQGDIELVQTSNIMPRSDDTQDDVQETVEDEQSSVPPVLQEDGTGPSSAAEAVSAEIDGAVPNEDAEEPRGVTDDARSFHEASAISAPQTLNLHGFELTPSSPGHPSMSIAEDNSSPRATAGESPSFSLGPVITPSAGLPAASEEISAEETTPNVEEAQRTKDEIGETSVETKAVSKEAPSLNQQQDAYDYSGDPELSPATQQAETDVAEVQEPVIGPESALAFDEPVLGEEQVDVARQDPPMAQAAEDVPQPSEQLPAAIGSLGSLPVESQHKDALNVSEPVMETDVAPEPSEPASEALVAVESSSVAPDMSRSAEVEDFPVKDRQDTLDATQFLAGAVTLPREEAGTSESTDGPDQEKGPDSGPYNHISLAPTSPTPSDHAIAIDTAQHDLPVDTSIASSGDVPSHPERTSESMENKKPFETPQDGDAINATPVPIASHLENDVRGLEESDTVASTPALIRVTESPVILHGTPPASPPPVDGQAPELIIPQPLAAGPDDDQPAVLIPIEDASPVEEPEEEKVVFFSVPETVDEEAEVEEERAEVSKHSSKEAPAVSELSDPGALNHDVEKKEEVQEESKERETPSVDPTVYDQGDTLATDDAEIPRDEEEVAVAPKLHPSQDSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ33</accession>
    <name>A0A1E3JZ33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034161.1">
        <property type="nucleotide sequence ID" value="XM_019173456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ33"/>
    <dbReference type="GeneID" id="30190503"/>
    <dbReference type="OrthoDB" id="10566536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="196" mass="21040" checksum="B3FA036A0CDE2005" modified="2017-01-18" version="1">MATAEDGGAESDVEGETVVAKGMSEEEYDEKVLRPQLANLEKLQDRLEAEYRERHQKEGTRWGRVETADSNWSKANMERQNVTSEPPSYLASPSQAVAAHSPERKNKDARKDRNDHVPGGLSAFVGVALPALVPEKKRGRPPKAKGPGEAEPGPKKKRGRPRKNPIPVDPSLSVPSAGSSSALGVPSSSLAPSSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZA5</accession>
    <name>A0A1E3JZA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thaumatin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034241.1">
        <property type="nucleotide sequence ID" value="XM_019173536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZA5"/>
    <dbReference type="GeneID" id="30190586"/>
    <dbReference type="OrthoDB" id="2575363at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130666" description="Thaumatin family protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="53527" checksum="467A89C154E959F5" modified="2017-01-18" version="1">MPLFSHSSLSPVALIILLISTTVLPTTLAERKITVNNKCSSSLYLAVGGQGGNVTKTDGSAQPGGWEQEPGEYTFIAPDGWNNARIWARTGCEKSGDSLDCIIGACTAGTIECDGTEFGAAGATLAEFTLNGYSGQDSYDISIVNGYNLPMTITPSDSSCTKSSCGAETDILTQCDPYLAYPQGNDKIYSCNSACGNSFQFQDLTSGAFISADTDNSPVCCRQGSDGVASEDCPNTYIPFYMTMKSMCQDGYVYADDDLYEGAVFSCAGTDDLSYTVTFCPSGDGAGLDPPSLSSASSQDSSPGDNTGNLKNASGEASIWASGVTGTPISSIAGASDGLSASTSSATSARASSGVGSAAVSWTGGVLSDAASSTLAAGGTSISDIAASSAIASSGAAVATTSAGAAAATAAISPVSSSAAAAVDPALSSAAAVDLAASSVAVPAYSSKAWGGGGAGGGGHWGGGWIGAIQVATSSPAPVAPISTTVPAEGVTATYTSDGDVYVQVNVVETQAVQGRNLDGMGSLKRKRWLGERDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG9</accession>
    <name>A0A1E3JZG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034275.1">
        <property type="nucleotide sequence ID" value="XM_019173570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG9"/>
    <dbReference type="GeneID" id="30190620"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="400" mass="43156" checksum="251BFADF081A02E6" modified="2017-01-18" version="1">MLPSFARSRVCARPFISSISPTSLTSSLRPFPSTTSSLLRSRVLTTSSTSLSSPSTSSPLDSTRPAPVPETSSSKITSELLAPKEVLPPTAPTIIDKLVPKWAEKAKPYLYLTRIDKPIGSILLYWPGAWAITMASTVHHLPPSVPIFYMGLFGVGALIMRGAGCIINDMWDAKMDRQVERTKTRPMASGEVTQLGALTFLASQLSIGLAVLTQLNWYSIALGASSLGLVALYPFMKRVTYFPQVVLGFTFNWGALLGWSAVAGVVDWSIATPMYLGGALWCVGYDMIYAHQDKTDDVLAGVKSMALYFPDTSRQVIAGLYTTFVSLLAFTGHMAGLGPLYYLISCGGAAAHLAWQVLTVNFDSRPDCWKKFSSNGYLGGLIWLGVAADYVQQVVLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZN3</accession>
    <name>A0A1E3JZN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF747-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034343.1">
        <property type="nucleotide sequence ID" value="XM_019173638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZN3"/>
    <dbReference type="GeneID" id="30190688"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="704"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89660" checksum="6AF51E50C367D601" modified="2017-01-18" version="1">MKEGGAYDTAEAGPSRPPLDTQRACSANEVLATSSSRSPSSTSSALDEGNESENDQHEMEAQSVEDSIPNRPSFQQRQSHVTPRRKPHLPHLSLDLPLHTSASELFSHPQSDSPMIDGDGIETEGSGGAKMSYSSLPPSPRGEFMGTPKEDIKVSGKDLSNLLGDLEMKRRGLGEEAVNLDTESETVVEGEEFWPARSRRPTLSEEDSYRRSTDDDDLTSPTSAAADTDSTRRGSDVKLGPIQSKTDVLGIWDLLKDEMGAEDWDGWVVDGKWERIANFLAVPLAVEKTTLFGALLCLDGFLYNFTILPIRSLFALTRIFNSIGMGKGWWPIPLAHINSILRMLLLVIPTVVLLIATDASKMYHTVRGQDTIKLYVIFNALEIADRLCCAFGQDVLDTLFAKETLSPSVRKRGKGRKRQQARPAFFFALSLGYVLCHSLIFFYMLVSLNVAINSYDYTLLSLLISNQFVEIKGSVFKKFEKENLFQIMCADIVERFQLSLMLAVIALRNIIEMSGSEIAFLPKSFMKGKSLVDSILSPILFVIMSEMIVDWLKHAFITKFNHVRASVYERFTDVLAKDVLLAGSLSSSAPLSDKRRQLAGRHRILLDQSPLVARRLGFASIPLACLVIRVAFQAIGMLTTQHGSYADERGELGSGGSWDSVWAGLKVASWVGVGVCAWGCLVFLKIILGLSLLGFSAMRQEGMDEREEEDKVNDFGRSAVGESKEETEYNRQTKEYLTQPADNLPDYPSFATSNSYNGSVPLPRAKQSNDHREKGGFAEEKAKSGGGKKGKKWRLEEVERWTMVKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZP8</accession>
    <name>A0A1E3JZP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription activator snf2l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034391.1">
        <property type="nucleotide sequence ID" value="XM_019173686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZP8"/>
    <dbReference type="GeneID" id="30190736"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000382">
        <property type="entry name" value="Transcription activator snf2l1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="234"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="531"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="889"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127317" checksum="A42E8890FED74B19" modified="2017-01-18" version="1">MWLTRTQNPLLAASSAAQNKEQEEDQLSDYVPNSRDLSVSRAPSVITSEEPRHLNTAPQSPEKDGEEEQEEDDELGDDDLDEDELADGKKVTPSVAKRAAQANAKKAQIAERKAQHAEISKKRDAIEQAQFADSMKRFNYLLGQTELFQHFIDLKKSREPEFARMLDEQLAKTSGKGKKKANDARHRKSEKEEDEELLKNGDDEEQPFVFEESPAYVKGGKMRDYQVQGLNWMVSLHHNGINGILADEMGLGKTLQTVSFIGYLKFHCATAGPHLIIVPKSTLDNWAREVAKWVPGFNTLVLQGSKEDRADLIAERVLTQDFDVLITSYEMCLREKSTLKRFSWEYIIIDEAHRIKNVDSLLSQIIRTFVSRGRLLITGTPLQNNLQELWALLNFILPDVFSSSEDFDAWFKTKDESDPDAVVKQLHKVLRPFLLRRVKADVEHSLLPKKEINLYVGMTEMQRKWYKSLLEKDIDAVNGMTGKKEGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPFTTDQHLIDNAGKMVILDKLLTSMKAKGSRVLIFSQMSRMLDILEDYCQFKNHQYCRIDGGTAHEDRIAAIDEYNAPDSEKFVFLLTTRAGGLGINLVTADIVVLFDSDWNPQADLQAMDRAHRIGQTKQVYVFRFVTQDAVEERILDRATQKLKLDQLVIQEGRAQQVAKAGQGKDDLLDMIQHGAEKIINNDQSMLIDDDIDEIIKRGEGKTKEINSKYAGLDLDALNNFKSESLVSTWEGEDYSNKQQKRPLLWIEPSKRERKTNYSVDQYYRDSLKTGGPKADKPKVARAPKQVIVNDFQFYPPRLIELQDKETDHHKKTINYQAPLREPEEGETKADVEAEQKEEQVRIENAVPLTEEEIAEKDNLIGEGFHDWQRRHFQSFIRALEKYGRDELDKVVTDVADRTEEEVREYAAVFFERYKELKDWERIMDRVRAGEEKIKEQQDRIDVLHRKIKANRFPLQELKIVYGQNKGKAYSDEEDRFLLVRMHHHGIDRDDCYELIKRDIGEWPLFRFDWFFKSRTPDELRRRAQTLLLCIMKEDDKVEDEKKPTKGKKRPIDDLKSGAGSRDTTPSVAGGKSHKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZW5</accession>
    <name>A0A1E3JZW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034449.1">
        <property type="nucleotide sequence ID" value="XM_019173744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZW5"/>
    <dbReference type="GeneID" id="30190794"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="615" mass="66525" checksum="4B30F0BDF4962E46" modified="2017-01-18" version="1">MEPSPSTSHAKPHAPQAKQPWYKQLSFQKSKKVFWRHLQFVGPGLVSSVAYIDPGNWATDLEAGADYGYKLLFVVLMAGLAAVVLQLLSVRLGTTTGLSLPAQTRILFLRLKERYPKYRIPLTIGLWSLYLLAELAIIATDLAELLGSAIALHLLFPKLPLFAGVIITAVDVLVVLLFFRSSSGRQGMMFFEFVIVALVLAVFISFMILLKLIHPVWKDVFFGLVPSHTLVKPGALYIGVGIIGATVMPHALFLGSFLAGVDRLNMVPTPPTKNVPKNIPMPSLNPFRRNRSPSPADSELGACASSLSRTASNTNIPEESPELGTVKNVDLVVEDSGMGKEDEAFALAQREYEREVRMFDRIRWVDLHLFHVTIDTTLSLLGFALTINASILTLAGAAYYYNTDSSAENAADLFGAFALIKSYIGNAAAIIFALALLCAGQSASITATLAGQVVSEGFINWKTSPFLRRLATRLIGVIPAAIVAAAVGAQGINIMLVASQVLLSIVLPTVIFPLVYLCSKVDLMTVQGPEVEDFELRHVDTPALAPSAEQEPVESSERTAVETPTGNDVVEPVSEGRRSKSYVSPKWVTVLGYALFGLVVLANGYVIVELCLGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K067</accession>
    <name>A0A1E3K067_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034545.1">
        <property type="nucleotide sequence ID" value="XM_019173840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190890"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="1405"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1356"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1552"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1361"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1605"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1654"/>
            <end position="1667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1667" mass="183586" checksum="BB5C4124F468EC23" modified="2017-01-18" version="1">MSEPPQLTDLPAQDAQELTAFVEKRRWFETKLKSLEEIPPVYPFVHPSLSRSRDSGLFVRDGEDGSQWQLPDQEQVKTWRKERATIEEQVFEFDGGDLERMKKKTRAATLLPLTPPSTHLVSITLDLIVLIDRILSLLRRRGLLLDLTNLRLQWDQTRWAAMTESESLQKEVDAMVHDKARWVPVDMSTPAPVKAGRKSLGATPDTSPQTPIVRDVSSNSISSDMGATAEGATKRRSSTASVNFSSGRPIGTPDRSLHIPLLHSQLVNLRIRHKNLAKTHMSRSGALLDRMIDVASHLRDLGDTKGPISVEADEKKDGGAVPDELLDLQDELDASVGELGEKVEWCGELEQHWKLSETHHSSSVQAEQLALTLIDELQIALTRPATSSEHRRLSALLEIASKRLPSPITSSFPRPSHEAYPDNDEYNENVVRALVRTHESASEEIRKGREGLDWYARLVKAKEAVLEQHTKLLSEKEAIAHLVRCLDNGQDDIPRPDIDDTSCLMTDHATWVTSVPSWVSQLEPFQESVPITVRSGTLAVYQYRAAYKTAPKSLRESLPEEVAGDEVDVAEADLERLTELLKRSRESATRAEQDFRILNIAQPIFTSSTTVHQTGLELKSTLHIALRATTSPTSLTSHEDYSEIKEKIKLLDGMIKQDVATPLSSLHFLLKECGRKLPVLRHDLSERSSNLIDQQTHLRSLLDLLKRARQQREVAKAVEAEATKFMRKLGLIKDEVERVREQGKVGELQRSLEVILVRVEGLWRDVEKWEGELAERTPFLAAAPPPVDNRVIPKAAAPIPPTSSSVPPMTPPASRSNTPQHPNSDIPIDLAAVDRKVRGIINAHAVSVQSAIAHCRSSCQAGILDLWIIQCVQAAQILDNSFIAWQKTNNKFSAQVENLSNRVAVPPTSVNAAKATVQAIEAMTASHEPRLRAHEKEIKEAEEALQGAVGHKPEWLRDADDVRVEEWDRAMVTATTAAADAGEQIKALDESAWELLKVAKERLERAVQNPRVLISPIAPSSLEDVFGPAASSPSSRTASPLASPLASPVDDLLSGIQQIQQELEGLQVELVVDPRSVEMQATPLLRRLPSEEVAGKIRGGLDRVAAKTKGLHVPPGHPAGASLLYLEDGLREKQSMLPRLKQLVHFSTAVKGCDAAFNSLLELVDNYGEHQKSFLLSEHRRVETILKDVYQLAEPVEKDRRVAREVKRLSNTRKDLKALVDECMDPSKKSNFDDAASEMTRADSVLSMASTVLPRTPSQSFSRLPRLSNSAFKSRVTPNTLTTPLRVSASLQAPTQSSRNRSVSDTPNRVLFGSPGDTSSLPTRARASLPLHSAGLPSLTGLPETGSRLRKSSIPMRARLPSTTSLSSLAVSPQFNGKQPPRLRRTGPLPSALGHSRVKREYVANPKNKLDVAVGKIVNKLDVAVPVRPVNQNPPHQVEEYQDMSGQYWIGSEGKAKLCFCRILRSRTVMVRVGGGWMELSKFLLDHFADLAVVPPLQPAVTGNGMRRSYSSSTSLYNMGANAPMPLTSASLAAQSAQTSLPLSHSTSTVASLLSTPAEEEVSPAHLASLPEDDPNHLSPEKKPRGSFGRATPRTPGSADRDKSFTSTSPLSTSASPGTNGSPLMAFHFMRKAAESPSARQKEKEKFKGRRSTLGREKSQTNLRAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0S0</accession>
    <name>A0A1E3K0S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034187.1">
        <property type="nucleotide sequence ID" value="XM_019173482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190530"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1391" mass="148752" checksum="48914D607DA892C4" modified="2017-01-18" version="1">MAPTPRKPVQRHEQSCDSSDSDISSVEDGDAYESPDNEEEDPDQEYNVDAIPYAYSFREPEKKSRGRKSQARVMREEAAKAKPQWHYGVIWKGYLKALSDSPQPVDSFEGPKPPVIVRFWAGMGMTPSDGSLEPLDKIGDRYFLPSHAMKQWLNEEPTRSWKLFKKRQELQRAHVERVSRGQATGMFRCPKRYSDHYHWLKFKKRSEQAMGMKTEGRRPFSSRILNRSSDESDLTEDDDAVPLKATQAPRRKAAGQGKPNIPNIKTDKPAASKRKSVVTSSTDSDSSVDTPLSSSRRIKVPRPSNSRSGSQAGVPKTGKPTEVKVEERDGATSEERVSETVEGQNDSAEKAPRAGSDKEGEKTGDAVDFGELDHGIFELPPLGVTESTATSAPITSERRSLSTAPTSAQAPPPASEYPTASDGTDKPPSSEKSIPPLGESAPTTVTAQASPSVNTSSSIPAAASTPAQVPVTAPNQPVAPAKTDKPPSSKGSVPLADNSVQSAVPSKDPPAVKSPTPASAQTSAQVPAPNPEQGIVTFGTDKPPSSKGSVPPPGKATPSTVPSEAPPTVHPPSSIPATASTSTQAPAPSPEQTAVPAATDKPSSSKGSVPPPGKAAQSTVPPKAPSSAKPPSSTSSNPPSSTSLAKPPAGAQKKVKESYDPRKVPRKDPKREALHASSAAQQTPAVAKDWLKTMKIAKRTQPVPEPASSTPPKPAQPSHAVLSTSDAVNHHSVHEPRREAATASGSTRPLSGPSPHAPAAALPEPSAAGPGIQPLRVDQPVRSSSISDALVGESPVTVGHSPGQTGERRAFHPGSIDLTTSHNIETSSLPSSTPAAILGPGGKERPKYEQPKRIKHIGNDDEIITPQEARKRRMTGEDGASPVSPKRSKTSYFPHTSKTTQRKKDTDFLASTTRLSVGRASEEQQRPGVAQRKTSDGTPAQMRRVGSTTSSLAGSMTPPPVPRGRASLDRSREGSGVTPTRDGTYSPPADRAGKPLNGVTRQGSADQPKPSIAIYQPRNKAQVPPQPPTTAVQSNAPNDPRLSISATQETSQSQSPAPLASGDNVQSQRQQQGTSHLGLTIVSSPSTIKPNYIPTPTSARPPAPVDSSPKALPTTSIPTPTTARLPSPLSKSPKLLLTLQRLRSDTKFPDGPELSDNGQAVPLASAANVDPFLCPVQSLNVIPENVVTLSPYLLLKHPKMWVRVMKALRGTRRWGAYLTPSVLCFLKQTWDDHDYDLSPDPTESFSALISSLPLDGGHAFHTGAPWGEAYGLSVSCNPPMKKLKRPLMEWRLWLTDVVRQNDFEALVKKCIGVEQGHFEQMVARDAGQALPAPDPVDREEVILEQLRDLTAMKTNDELVYTRYVYVGHFELGDANRKKVERNYSHGVSPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1A5</accession>
    <name>A0A1E3K1A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034337.1">
        <property type="nucleotide sequence ID" value="XM_019173632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1A5"/>
    <dbReference type="GeneID" id="30190682"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="10446" checksum="F8B721C5F720DE18" modified="2017-01-18" version="1">MSAPLQQSTAQNTVPAQTAQPSFLQKKGLLGAAARGGVKPSNTVSPSDVLSPISAKLNNSKQRHFQKGRPVHLASQLSQLASQASPASKENKPKIDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C4</accession>
    <name>A0A1E3K2C4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034805.1">
        <property type="nucleotide sequence ID" value="XM_019173079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2C4"/>
    <dbReference type="GeneID" id="30190120"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="402" mass="43164" checksum="EC484DC15740E956" modified="2017-01-18" version="1">MSEPPSNPSGDSSTSTAAAPVPKPCKICLAPAKYTCPRCSSTTCSLACVKLHKQNDTCSGVRDPAKYVPLNQFTQGTWSDDYKWLEDGRRQVAGWGQGVKVEEVAGGGNAGRGRGRGRGGPAGRGQKRSRTDGMRRELLKLGCRAEFMPEGMGRKKMNQSSWNQKSGQLHLTIHLIIPHTLLAEPTTSPSSSSKTIAHPRVLFASNDDSATLPNLSSFLPPLNTPVAELQLLLPFYSTPSHPAPSHELHQQLFYPPLDADKPLKEVLQGAAWVEFPEIRVMLKDEWEKKIQKGEVVIIGREETQYDGIAGVAERTRDSGWGAKRSGAPLTAGGAEAAVPAKKAKVDAGTSLLALGDYASDEDSDEEVGEEGQIEEGEDEGEDPSLEVMEAVGRALIADLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2E9</accession>
    <name>A0A1E3K2E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034702.1">
        <property type="nucleotide sequence ID" value="XM_019172976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190017"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="123"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="968"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142619" checksum="C32EBED4C59E906A" modified="2017-01-18" version="1">MSRQPPGDNTPSRDVVLPHPAEDLSADDDLLSWVLVDQLGSMPNTKLGVHPQQVKFVGPVFKTDEVLNIVRETVTKGNIQAAMQRLQEFHLFRQHIDTKITAGQKERFIKHLRRYLLVLQPASRLEIHLTSRYTFITGHTELAVFATRPLIPGTVMQELQGSVVPLPNEWREEMDIGDDYAVEAAGEESDSEDENAMEEEDDGRDTESAAEGSSRRRRAREERKQQGQRRSDRTKRRDFSIVWSGLKRCYQLFLGPARFLNHDCNPNVELLRQGNYVTFRVTKPIKIGDELTTFYLCLTCEQQEKGGFAPKPPPTSRASSRRGTRGLSTTSDSQYRSRRGSTHDSTFVREPSSLRNEVTVKAEPMSDNEEEEEIDFGPSMTLLAQSGRGTEEGSLSAVAEVSNAVTPFEDNEDWGNVKRESSVATEDEENGPPRRERYARKATQALKPWLEPKHKGKYVEQEVQYVGNDEDVPCDFPRCATCAKPLTDQIWYNGRYFDHCQRCVRHALVFDLPWPAHRSQDIQEYPPAHLVPPGFIPRKISTVPLPSLSKAPRIKPVKFIVTEEQDGYHDGFYDRRARRLRDEIDAETFVIESLREAAWSVQEAREAAQEAKEEEKKRRLEEKRKLDATRVKGSGVWSRYEYVDEQAMRKKEEDRWKVQPGLTRRGTVRSVPQPDGDDEGEDQWQPITVKQEVQSEDEDSGAKTESEEDLNRRNANKAAGLAKRRETIRLAREKKQAQDAARRIRAAEQKQKRAEKLREEKEEKEKRKTEGASSSEEEEEDRQVFKRVTRSGGKHNPIVIDGEDDIQPAVRRPPRAVEKRPRAWGTQGAPIVIDDDDLEDEIRVAAVAGHGRAQMARKSGPSSKPARSQSGVGDGPQESRASTSAQRSKSTPKQTPRSGSTGVRSSGRKTKPTPKVLEQPVSGSRPRRKTADVATDASSGTPQSRTPRLVLKIAAARPVQLNGAEVNGASSPGPSSTSARLTTTPIAPSSNTSIQSESLRKRGRPPGTGKWQIAAAARARSAKDKAAHAPEQGDGAGPSIVNDMERQKEILLQAAVASTPEESTFGTGNFDSRSPEKLRANEAIRSPLNGKEKNNGVAGGSTHTDKGKGKAVHPIEYPDYSASASKVLKKVVPPASFFATAAQHAQSAKVHPPPWSYPSQPPAAQSSKVHPPPWSYSSQPPAIPKLADTTLNGASSYKKNLSTSAPRRSEVATPSASYKPGSFSTNGDHRQSTTKRLIPSEDMVARSAREDVKGKKRARPDPESPFPSPSQPLSKKTRTDVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2P9</accession>
    <name>A0A1E3K2P9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3 small nucleolar ribonucleoprotein LCP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034582.1">
        <property type="nucleotide sequence ID" value="XM_019173877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2P9"/>
    <dbReference type="GeneID" id="30190927"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="42518" checksum="E69AA60B29FED18E" modified="2017-01-18" version="1">MESDAEVILSTDEVLKLFGTIQTAVDATISSSTFLFNKVEQKDEALEFGQGLSLLNLRPHLLLSSLHQLVILLSLSLTSPQEEQPNPASSSSLTTPFTNPRSRPELSSLTDILTELAGELVMNQEVMDKTRSLENKLEYQIKKLVGLAEAEEKRGKEVVEDVEEDPLSFRPNPTAIVNRNAPKLREGTPSDDDEAEGGDGIYRPPRVAAMPYSEEGAPSRRERERRAPALLSEFAATMDSAPLLESTSGLSVRPTSSTLAKHSNSISAKRAAELKRINEFEEENMTRLVTSKRDEKRRREDEEALAMGFGVGPSRGRRGRNGLEAELEGVLGERGDKGVWDGVSGKFGARGEVLERGKKRTGGSGAGTSGSGGKAKKARFEKELARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2V2</accession>
    <name>A0A1E3K2V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034985.1">
        <property type="nucleotide sequence ID" value="XM_019173259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2V2"/>
    <dbReference type="GeneID" id="30190300"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="878"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="100389" checksum="096D0690914B78A3" modified="2017-01-18" version="1">MGGDHKCPLCSATFTRPQHVGRHLRAHTGDRPYACKECPLKFARSDLLSRHVNKAHRSPDVGPVDKKTSKKGRRKSVPASAHSSLERDKIIAEQQQQQQQQDYQRQQALQQQQQAHAQQQQQAARERSRSESHVIQQPQLQAQRMYPHHPLLAVHPVPPAQPGVPQESWNANPSGSVGTFGMMTMSPQPTYGPSVGRPMPVNPPVHSATYPLQPSFDPPFTAQPLKMSGSMDQHNPSQSMYEWDTKKRACDQCNHSKVRCDFADPCLRCKQRNLTCSYRKPQRPSSCMGPPLPPAQVAPVPSSSPSNMSISPHSSNQPSPQFTQMQMPSIAPTEPVVYRKPSVSSLPPNLGNVPNPNPSPVMSHGPAHAIGGWGSFPQTTVGGTWPSNMVAQQSLSFADNTAPGSITGQAFETSPNSLDVPLPAPASPIPPNANASGKISPGRMGLLQTPSLVSNTDSPSEMDEPVERRGSHNSAISAASSSAPAPFWTKGKGPEGTLGFQPNMPNIHTHQDISPSHSQSQLPFLAGSGSQLNDPQGQQQWHMRDSFSGSDDTSSILSSSVTSSCMFDPNSSVSGASAGHQPGHARRRSSQTAWAHALEQMTLGESQKQALAASMREGSESAVSAHSELSPEGGRQPAQLQPEGQQIMPTLSDVKDLWKVFMSEPMDLTGLAPVAEGDGSGMDLDHTHEITPRPGLGKRTLSKSNSMPDLQSPMINGPNFFSTFLNGLTPKASEAHASQSYIGVQVPSEQGHGQGPQEGGGSIPDIGSWKDQIQQRQSSFSLGAPGSRLGKSKLKGSQSALPLDTAVPPPSRPLPSVVQRTALDQTLAPERIPSFGLTPGLEMSTNPHLASKLLQSTTPALTGAAGLTSAEAQAGSKRMASSSLANEHGKRASFSVWGEEEPVAGDEDVQDPATGEPLYAGARDKVPLAGQQQGLVQGWAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K320</accession>
    <name>A0A1E3K320_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00922</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034820.1">
        <property type="nucleotide sequence ID" value="XM_019173094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K320"/>
    <dbReference type="GeneID" id="30190135"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="13">
        <location>
            <begin position="101"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="14">
        <location>
            <begin position="494"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO07343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="742" mass="82837" checksum="C7334986CD8C2EEE" modified="2017-01-18" version="1">MFRARSFMTGRRALVLTTSTTVAVGSYLYARQQNRVQLDWQPGSKTDVPDPLWNPPSRSQMVDHLRTSGLHIKRTQEGGPNPAIDVPTTDVEEKDDDDVFDLLIIGGGATGAGAVLDAASRGLKVACVEREDFASGTSSKSTKLVHGGVRYLQKAIMELDYDQWKMVKEALRERKIFLDTAPHLSHMLPILLPIYTWWQLPYYYAGCKVYDFLAGKENMESAYWMGKGKSLEAFPTLKKEGLVGGVVYYDGQHNDSRMNISIIMTAVQQGAIVSNYTEVTELHKKPDPSRGGQERIYAATIKDSLTGELMKVRCRGVINATGPFSDGVRRLDEPSAQEIVAPSAGVHITLPSYYGSQRLGLLDPATSDGRVVFFLPWQGQIIAGTTDSPTDVSQNPIPEEKQIQWILDEVRHYLAPEIQVRRGDVLSAWSGIRPLVKDPGSSNTESLVRNHMINTSKGGLLTIAGGKWTTYREMAEQTIDAAVKEFKLKPNGPCQTHRVKLIGAHSWNKTMYIKLIQDFGLETDVAQHLSESYGDRAFTVATMALPTGKNWPIHGVRFHNSYPYIEAEARYACRCEYAVTAADFVARRTRLGFLDVQATVESLPRVLDIMGEELGWDRARKEVEFDEVVGFLRSMGLPEVSQVSSSNDQVLRVKERYIAQLDLQQRRLLPAIETSLSSKIKNQELKLIHDTLQETHLRLRDVERNAGHIGPLGLAQKEEIEVIASNMPASHPEVKGTNFHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K365</accession>
    <name>A0A1E3K365_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034948.1">
        <property type="nucleotide sequence ID" value="XM_019173222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K365"/>
    <dbReference type="GeneID" id="30190263"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130724" evidence="3">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="193" mass="21022" checksum="8339466C503458A2" modified="2017-01-18" version="1">MTRITTLFIFCLSLFLLAGPASAAIFDDPGLSYCKCVCFTNSTIIPLYRPENPKKPCLSCTRQFCLDQKLAICKGAEVPELDTDVGTGTEGDVEARCFKRDSPRDQLFVTFFLLIVVGLLLYAAIRSRLRKAIEERGRPTDLRQWAEALIPEPLQQYSMAFLPGAQNRGDRAGGGMRSAGGSAGGYTPVSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3B7</accession>
    <name>A0A1E3K3B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035022.1">
        <property type="nucleotide sequence ID" value="XM_019173296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3B7"/>
    <dbReference type="GeneID" id="30190337"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="217" mass="23972" checksum="0A3906F4170620D5" modified="2017-01-18" version="1">MSTPTPRGAFIVFEGLDRCGKSTQVERLVGQLEKQGRKARLQKFPDRTTQIGKMIDAYLQSKAEMDDHAIHLLFSANRWECAEGIKRDLAAGITVIADRYAFSGIAFSAAKGLPFDFCLHPDTALPLPDLTLYLTLPPASAAQRSAFGTERYETVEIQQAVREQFKLVQEQVVQRHGEERWVEVNAEGTIEEVGEKIGVLVAGVAAGREGDVGQLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3C9</accession>
    <name>A0A1E3K3C9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Archaeal ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035032.1">
        <property type="nucleotide sequence ID" value="XM_019173306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3C9"/>
    <dbReference type="GeneID" id="30190347"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="156" mass="17387" checksum="60BBD6D5F4264CA7" modified="2017-01-18" version="1">MAPSKTTSGSKAAAKPQDVKAKAAKKAALKGTQSTNVRKVRTSVSFHRPTTLRLARAPKYPRKAIPHLPRMDQFRTIQHPLNTESAMKKIEEHNTLVFIVDLKANKRNIKDAVKKLYDVEAAKVNTLIRPDGKKKAYVRLTADFDALEVANKIGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3D7</accession>
    <name>A0A1E3K3D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035042.1">
        <property type="nucleotide sequence ID" value="XM_019173316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3D7"/>
    <dbReference type="GeneID" id="30190357"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="61344" checksum="82267106404E6560" modified="2017-01-18" version="1">MSITGSLLCRKSLQSSARSLLPLPTFLAPSVSVPSRVDRRHKSSASTPGAPEKKSLKDKYNYNTSIDFDGEPDPDHVRWRRVTAADLVARKEPPTRVKMLVRDFIDDSLYNPNYGYFSKNATIFTPPKEGFDIPTFRDTAHFQETVAEVYEREYGLEQTEGAKGGLSRQVWHTPTELFKPWYAVSLISAIIQSYKLYHFPSEPLVIYEVGAGNGSFMVDAMRYIKENHPEIYPKTSYRIIEISAALAKGQKERAEKEGFGSKVQVLNRDFFKWEGVSNGEQPCYVVALEVFDNLAHDMVRYELDTLEPRQAVVGIDASGEFSLLYEPVHDPLINRVLSYRRLLPPSPATSPPLAKPLLVSESLRKLYTSLPFAPNMSAPDFLPTKAVLFAEKLREKLPGHRLLMADFDELPEAVEGRNGPVVQTRYGNSMVPCETFLVKQGYFDIFFPTDFEHFRDLYSVIMNSPSVSAPQPPPPSAFNPASKISRDFFSHSSGVKGFRRRNVGIYTHAEFLEKYGGKDVLDKTRVRDGGNVMTGMYANAKMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3I7</accession>
    <name>A0A1E3K3I7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035078.1">
        <property type="nucleotide sequence ID" value="XM_019173352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3I7"/>
    <dbReference type="GeneID" id="30190395"/>
    <dbReference type="OrthoDB" id="10277295at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO07601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10783" checksum="AA913FFA489E783D" modified="2017-01-18" version="1">MSLMEKSRIPNPQFVQFMISNGLSCSGPDVSRIPNYAQKELLRKMFESVCAVWRVRRQWGRYPPGGIMVYQADGLCDACEARYFATLMRARHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K463</accession>
    <name>A0A1E3K463_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035090.1">
        <property type="nucleotide sequence ID" value="XM_019173364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K463"/>
    <dbReference type="GeneID" id="30190407"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="245" mass="27297" checksum="C0E55079118CBE19" modified="2017-01-18" version="1">MIDQDQHVLTDTFSSPAGRNGGHCAPYSFSALPELTKPLSEGGAGLSIDDALDVLDLERRVLLWVEETVHREGWEIDLWKGEKVEGAPGSLLAIAQRMDGLYKKWAEARNKSEKYKDIPLEWSWTWDEKKAQADTRFKGAVAYSKGPAGSIHPHKLASAFLRSALKSGQAELYSWVPVQGIQKVDGAATVEKQSENGLWEVNLGKRGKLRARNVVICTNAYTPGLLKGTDIERLYALFHSTRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4L8</accession>
    <name>A0A1E3K4L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034934.1">
        <property type="nucleotide sequence ID" value="XM_019173208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4L8"/>
    <dbReference type="GeneID" id="30190249"/>
    <dbReference type="OrthoDB" id="2564766at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="860" mass="91990" checksum="2BDC4A9954499AAA" modified="2017-01-18" version="1">MMEAGHGPIHPSGPIYISAQAQQPPPHGHAPHPFVHQASLPQQQHLYYPPQPARPASPEELNGVPCLQVTQPTPTKGRKYRTASDAGGSTSGESLYMASPTWRTGPMIPSPGSAGGSLDVSVEPLQHYAGPPVRASRPRSPDVEQFREGSEDGKEAKRKQRAREMGRERQRRKRERDKKAREEAMKGKSQSRDDVPSGRRTSNTSYTGSQNSLSITVPSPASAYSPLGTSSSYFSISPSGHQLGQKSGQSSPGAFFSPTVSTPSSFLESNGTSYWGEGKAGAGGLDLSANKPTRPVRPSRVSSGNVPTGATLKISSSTGLPVPPNSNSTSQPIVGPAPPTKRRKSEPKPDTFRATRENSFGRVQSLAALDWAKDDRPRLQRTSSDGAVLRRIDTKEKSRSLTPPPVPLLPEQFRHQSRLSMADTGELTGASSEGQYFASFIVHEAASSNSEDAVLMRERLGLGIEEMSSMKDNIAMAYDKWKLERGMSKISLGSDSIRPSTAPSASQSPRGSRTSLPDPNIFTPVSNMPVRYARVPNTLPMSTSYAQHQPQDSPLTSVAQGRGRSLSSLSMTAVIESAQWSVSDTPGAVPAGAMVKDDTGSPNTSSIHTPSTGQGAFPIMETNAPPKALWTDPVGGRMYHAYHNAPGVQSIQSRDEFNQKFVFGGEGQLLDSPLSMTGQVEGMRLDMPPPPPSAGGVHLPRQLSMSAPSAADRPTSSSSRHERHASASVVSTREAGHFRTPSGPRSAGLRNVQTQFTPPTPLSARGSGSIQSQQNTAPGYAADEQMDGMLFYTGVFGTAPQQSQGPQETQVKEALPQQQQQENFSFMPSQPYPSAPPVTQGSFQTSQPLATFSSQQSENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5K8</accession>
    <name>A0A1E3K5K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035287.1">
        <property type="nucleotide sequence ID" value="XM_019172345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5K8"/>
    <dbReference type="GeneID" id="30189375"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="358" mass="39130" checksum="72065560A9EA683B" modified="2017-01-18" version="1">MSSSEIKPEFHRPVRQSALRAPSITTALALGNAIDDGDESETEFKRPSLPPSTSGSSTDTPPKKRRGRPPGSTNKGAKASFFGSSKKPLGKAREGRRAGEACTWCRYRRQKCDERDNCSLCQKDKKGCVYLSKLPRHQRDALSKPISLDDWNDMKDDIQFIGAGAGTLPTPPPSPAVLQKKKFVNEMKSEATAPVPSYRRLSMDEDENDAMSGDESDSESPFPATFDTSYPTPSPNRATHLALSPRSHPFSLLAEQSQRTDFFGTIDPQRIHDPSSIAPGGLEHNALAISSCASGSSSEGAHVTLGDVELDSFEWCAEEFRVGGEEGELVQTHVDEFTEAAKKSWSTMNEFTPYQTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6A0</accession>
    <name>A0A1E3K6A0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate lyase subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035525.1">
        <property type="nucleotide sequence ID" value="XM_019172583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6A0"/>
    <dbReference type="GeneID" id="30189615"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000023">
        <property type="entry name" value="CitE, Citrate lyase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="335" mass="36540" checksum="B64B343513727A04" modified="2017-01-18" version="1">MASSSIHNTLKQWRLPVSSSRRLSTVSSTARLPVSRRAMLYVPGSNPRMLEKSLSSPADSIAYDLEDSVSPGKKTEARKLISDLLNGERRPRGEVVARVNAIGTGYEEEDLDAVLRTRHVEAIALPKTDCPDHIEYVISRINALSAPHKRSGQPGAIKIIAMIENARAMMAIESIAQSGKGHLDALLFAAEDYCADVGLTRTPTREELLYPRSKLVTTAKAFGLQAIDLVCVNYKDKSVLADESEEGKRLGFDGKQAIHPEQIDIIHSSFAPSEKAILKAARVKFSFEHHDNLGKGAYTLDGVMIDAPVYKQATKLLAKAEAAGLSLPRVTLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6D9</accession>
    <name>A0A1E3K6D9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035565.1">
        <property type="nucleotide sequence ID" value="XM_019172623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6D9"/>
    <dbReference type="GeneID" id="30189656"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="233" mass="25974" checksum="643AECC4CAC226BD" modified="2017-01-18" version="1">MTSFLRTNFLRTRLPNLASPASCSRIASTTRLFSSAAQLPPSEKDPSHPHLWYHPSSSYISLSFLPTKPAVYGSKTVIGYLPLGEATLDDFRDEPKFEKVLEDAVKDGLAKGKATTVEFEAETRPTDGWIHITDERAIPPMGRIGETEDIIGSVYVQEGKVITTAMLMCYKTMLTFHGVNMKIIADTYSAFPTYRLVTTNGVLRLPRGLDEHLVETLKKIDEEEKRESAATVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6S7</accession>
    <name>A0A1E3K6S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035644.1">
        <property type="nucleotide sequence ID" value="XM_019172702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6S7"/>
    <dbReference type="GeneID" id="30189735"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="645" mass="70095" checksum="5E3A88E2CD513385" modified="2017-01-18" version="1">MSRPSPHAPTSTRSASSPPVGRSPIGRDTTNAESHLHPSDHLAAIDQGLNDTRVPPPIYLRGSSAGGISNKGEIKIHLSQWYGYVQTTMRPSSSDYRRKAQVRPPRPFDNLSDQGIISPPSEDTVVQGSLEIIMNEGVRAKAISVGVQSVCRLYLGLDRGWEEDGIFERGIEILGDREEGIWLEKGSQSFSFTIVLPGTLAVTANSTFGRVTHIVTARVEGGEAASYFSSFISKAFSPPSIPSKISNIGDFDRVIARSDELALRRSRSASTSRAVPNNGPAMDGRTSRDSEDSGQGSTIVTAEGSPSVLGLYTRRPSFESSPARSPRRLPITPDGECPSPVFSPLNGEKSGWMKGDLTSHDGLIVFAVSPYTGDGMTLDVRKEGLVDGLGLWRFTAGADVFTVGSVLMLSVSISSPSPKTTIFYTRFLLSEDYTITSPRTPNLPATRPESAQRHLLYQLGRPHKPGEKRPGRDVDALWRGAGVGGCPEEAGWKIKAMARAPGHMKIKPTTHERTITPLRISHDLIFQIYYSVDGEKVDGEPIDGPGELRVMQIKVPVIMSSCHCVKDALSLPTYETAQCAHRGDGPFFDIPMDLKMYCVCRSSFAELGEAAMRRSQGNEREEHEERPVEGSGDKAREDMANQGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T0</accession>
    <name>A0A1E3K6T0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00633</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035749.1">
        <property type="nucleotide sequence ID" value="XM_019172807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T0"/>
    <dbReference type="GeneID" id="30189846"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="453"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="695"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1096" mass="118011" checksum="4725993654CB60B4" modified="2017-01-18" version="1">MTTAAPTALPASTHLEELVKLASSANNVEAKAVADGIALSLKKAPKTLNAIQDAKIIDVVLAWAGSKAASEKEAAAVLVERLSRSLGTGVEGVFLPLVPAILNLSQDKVQQIRTSVNSAMVSLIKAVAPEGVRSVFEVLIKVLDDSKQWRTQVAALKAMEGLVKAGSEEYVANELGHVIPVVEHAMHDTKSEVSSAAKKAATTLCGTLPNPDVLKHVDLLVSAMASPAAVPSTIKGLSSTTFVAEVNAPTLAVLVPLLTRALKERSTDTQRMTCVVIGNLVKLVRDPTVAARYLGPLFGGVKQLATGAAFPEIRAFAQTALDILIGAGASADATPLPPRDVTLAVTEALAVMAPHFDIAEFPAHPSLPLSASLPNSPVIAHAIEYQANIVADLVDARKWDASAWEGKALGSFMKLLQGAEEGAKSTAAIRQAFMDIDKAKFAPDVEDDGSEGQLLCDIQFSLAYGGLLLLNHTNLKLRRGRRYGICAGNGAGKSTLMKAIRDGKVEGFPPQDQLRTIMVEHAMQGEDASAAILDFICADPKLTHKTRAEVAAMLLSVGFSDEKQQDPVASLSGGWKMKLELAKAMLIGADILLLDEPTNHLDVQTVAWLEQYICSLTEVTCMIVSHDSGFLDNVCTDIIHYETKKLAYYPGNLSAFVAKVPEAKSYYTLAATSIKFSFPPPGNLVGVRSNTRAILKLSNATFTYPGAAKPSLKNLSCSLSLSSRVGIVGPNGAGKSTLIKLLTGETVPQEGAVHKHPALRVGYVAQHAFHHINLHLDKTAVQYIQWRYQDGHDREMMEKATRVFTDEDKEMMDRPIEGKNGELRKIEFILGRQKLKKSFQYEVKFKGYDHKYNAWIGRDVLLEKGFQKLVTQFDDLESSREGAGQRDTGATAVREVLEAVGLDGDIAQYNEMSGLSGGQKVKVVIAASMFNRPQCLFLDEPTNFLDREALGGLAVAIKEWGGAVCIISHSTEFVNALCPEIWNVDNGELTHQGKVAIVEDAFDNPSQPGSRVPSKAGTPRTIPGTPLTAATSGTATPDGSSAVEDVTDGLAKLMEKKKKKKKMTRNELKAQEERRRMRKVNWLAYGGEREPDTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K706</accession>
    <name>A0A1E3K706_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S small subunit ribosomal protein L30e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035724.1">
        <property type="nucleotide sequence ID" value="XM_019172782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K706"/>
    <dbReference type="GeneID" id="30189818"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="12458" checksum="A56B3483DA3A50CA" modified="2017-01-18" version="1">MAPVKKSKSARNSESVNSKLQLVVKSGKYTLGYKQALKQLRSGKAKLILISKNCPPIRKSEIEYYAMLSKTRVHHYEGSNVDLGTAAGKLYRVGVMSIQDAGDSDLLQDQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K796</accession>
    <name>A0A1E3K796_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035588.1">
        <property type="nucleotide sequence ID" value="XM_019172646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K796"/>
    <dbReference type="GeneID" id="30189679"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="167"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="462" mass="50117" checksum="3EED3CFFD835F48E" modified="2017-01-18" version="1">MSWNQYPGGGHQQQGGYGYQPPQQQQWQNNPPPPMGAQGYGRPPPPPMQMQGGYHNNPPPPQQYSAPSGGYSSGGGYQQQHSQPHQGNYRLSGGYVPPTNAPVESSYHQTGAGYMPPSQPQGQFAPYGNQGMPARPPTQSQHYGPQFQGQGGQQAQPYFQYSQCTGKKKALCIGINYIGTSSALAGCINDAHNVQKFLIQRYGYKSEDIVMLTDDARNTRQIPTRANMIAAMRWLVSGASPNDSLFFHYSGHGGQTEDLDGDEDDGHDETIYPLDFKQSGHIVDDEMHDIMVKPLPAGCRLTAIFDSCHSGTALDLPYVYSTEGVIKEPNLLAEAGSGLLSAGMSYLRGDTGGMLSGIMGIGKKVYNNNSGAAERTKQSKTSPADVVMWSGCKDSQTSADTQEAGRATGAMSYAFIAALTKYQQQSYVQLLNTIRDELKGKYDQKPQLSASHPMDTNLLFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7D5</accession>
    <name>A0A1E3K7D5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035304.1">
        <property type="nucleotide sequence ID" value="XM_019172362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7D5"/>
    <dbReference type="GeneID" id="30189392"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="137" mass="15239" checksum="B4C214F09F1E6A9B" modified="2017-01-18" version="1">MTYPQSWLCKEYEKWMSEKALKNPDLAFTASLRYTYKRAEGSKTNESCTSKNSLLYTVFDLKDDELLDIVCPAVFEVKSIVTSAATALVQEAAYLLGDHAACGWYLGGFAVDRGHACMIVLDDKTVLFEVPNGIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7I9</accession>
    <name>A0A1E3K7I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_00623</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035741.1">
        <property type="nucleotide sequence ID" value="XM_019172799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7I9"/>
    <dbReference type="GeneID" id="30189836"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="73"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO08886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="474" mass="51710" checksum="43E0AA98C71002FE" modified="2017-01-18" version="1">MSAPAPNSGAIITQPPPPSTLREQRIATHSHIKGLGLADDGTAMTTSQGFIGQVLAREALGLHLSLLKGGKYSGRPLLLVGPPGTGKTALALALSQELGSKVPFCAMVGSEVYSGEVKKTEVLGSCFRRAIGLRIKETKEVYEGEVTELTPSEVENPLSGYGKTISHVIVGLKTVKGTKQLRLDPSVYESIQKERVVVGDVIYIEANTGAVKRVGRSDAYASEYDLEAEEYVPLPKGDVHKRKELVQDVTLHDLDMANARPQGGQDIMSVMGQLVKGGRTEVTDKLRREINKVVDRYIEQGVAELVPGVLFIDEVHMLDMECFTYLNRALESPMSPYVVLASNRGISTIRGTEYDSASGGIRAPHGLPVDLLDRCMIVKTQLYTRDEIRRIVDLRCRVEGISHTPEALEKLADEGEKSSLRYALQLLTPAAIISRNKGKGEVSVADVEELGELFLDAKRSTGVLRGQEDFEKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7J6</accession>
    <name>A0A1E3K7J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_00237</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035364.1">
        <property type="nucleotide sequence ID" value="XM_019172422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7J6"/>
    <dbReference type="GeneID" id="30189452"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="160"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="268"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO08507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="422" mass="45681" checksum="6647BAC0C68A99E6" modified="2017-01-18" version="1">MSALTTLRPALRTVRPIALSATRGMVSKFVKYDWEDPLDLKSLLTEEEIAIHETAKAYAQENLLPRVVEAYRTAKFDPKIMREMGELGLLGATIQGYGCAGVSSVSYGLIAREVERVDSGYRSAMSVQSSLVMHPINEFGTEEQKEKYIPKLATGEYIGAFGLTEPNHGSDPSSMETTATKTADGWVLNGSKTWISNAPVADVFVVWARVVEDGEKGKVRGFLLEKGSKGLEAPKIANKIALRASITGSIFMDGVKVGDDALLPKSGGLGSPFSCLNNARYGISWGVMGALEDVVARTRDYALERNQFKRPLASFQLIQKKLADASTATTLGLLGALQLGRLKDKGTWSPDMVSMMKRNNCGEALHHSRVLLDVLGGNACSDEYHVGRHAANLQVANTYEGTHDIHALILGKAMTGLQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HB87</accession>
    <name>A0A1E3HB87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000067">
        <property type="protein sequence ID" value="ODN73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027764.1">
        <property type="nucleotide sequence ID" value="XM_019180261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HB87"/>
    <dbReference type="GeneID" id="30197506"/>
    <dbReference type="OrthoDB" id="2569417at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="300" mass="33574" checksum="3238D3214A37024F" modified="2017-01-18" version="1">MDRDDANLIGALLDELDLRDAQAPSFDSFSDLSASPLFSLPSPAQAQALPARLRDLRIQAGSKVLVYAICEDQPSCSAKRPPSADNLPSSIHPDYSLQTGNDFLLVTDDDVGFYVDRDFLLCHSELFHDFENMACDISNKDAIGDCIKSSVVRRDMPGALSKGLRVVLLNSADTDSTWPDFHDFDNESDWSPQRQTWPYTLEDLALAIKIANQYGFTSFSSQAHSKAPRKSLWFQYLLAAFESDERGANAIAKSTLYFNLETCCPLALLSILDKHNAPYATLLRDIHDFVLLQRIYRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD46</accession>
    <name>A0A1E3HD46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000061">
        <property type="protein sequence ID" value="ODN74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027803.1">
        <property type="nucleotide sequence ID" value="XM_019180221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD46"/>
    <dbReference type="GeneID" id="30197463"/>
    <dbReference type="OrthoDB" id="2540399at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="66472" checksum="CD80DDF2E2AE0651" modified="2017-01-18" version="1">MAAQRQLPYLPYFPTLDLAIAAADGTKRVWARDRLLGDRQGSKQYVVARERALYQELLRRDAKHRVYYEVLLSGTATRFYLDVEFERATSDAELSIVKSNVMHYFNDENDAQLRGSLMVRSRALKDTAFSEQTASKVIHQIQDMLATGLQARFDPPENVLAGTVVMTASTPSKLSFHIVTNVSIDDQKSSGAALAYDLGMSFRLYFVMVMREIHAADPGLTSQRAEVLLILLQLHKRGKSSFAMDLAPYARRQLFRLGGCTKAHQKRFLRPLAVNVPVITGADSPVPTMASLFPSSASWAATLCQGGHADLWPNDHEISYAYNSSYPWPKPVGADGNMDQYPHVSEFIHDHSTAERLRLAGQPGIRAAAPHVRLATVVPGHTSVLDDITVIVGEDGVSTRAFVEYREHEQVYCPRCETNAKTDAQGRTVGYEGVGPDPSAVITLSASGQNALYCFADCKTMFFCSLTFVRQPMYVQPHQEVHLASGADRINMNGRQDFKIDPSTRLSAVSAPTGAGKSTLITSYLDGHPEAKVLAISYRQSLACYQANRWSCKQWSPLLHDLTIFGRVSALAAFPRLNHFQPRFGINSSGINFCSRLGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HFU4</accession>
    <name>A0A1E3HFU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionyl-tRNA formyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027878.1">
        <property type="nucleotide sequence ID" value="XM_019180152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HFU4"/>
    <dbReference type="GeneID" id="30197392"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN74995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39745" checksum="527FDFED5FF72D79" modified="2017-01-18" version="1">MLLSILLHLSGHYRVPLELGSLASTAHPLSVSTSRAYGPILSTSASPTGASTTPSLPASFGITSTPAQQKIPLLVTSVDSFTQRVLSYLQILGFEHVSVRLAISNEAMLESAESWQPDIVLCPFLTNKVSPSIYNTWITLVVHPGLPGNAGSSSLDWDLLGDNGAVPFSTDLLPALLSTLPSPVAQRPHWGTICFQATEDLDDGVNLHSPAVMTAVITALIRVYGKTAGMDKAEGMNVAPEKGWQELSVSLGERFLGGKTHERPLLQFAKRKPDWEKHTAEDVLRILNASDSQPSAMLHPLTSASKASLFAYGAHLHKKQDIDNEKKTLKAEDAGVEEIEEMEVKWYLRKMDVCRMRIMCLHGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPE2</accession>
    <name>A0A1E3HPE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028081.1">
        <property type="nucleotide sequence ID" value="XM_019179959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPE2"/>
    <dbReference type="GeneID" id="30197197"/>
    <dbReference type="OrthoDB" id="2577424at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="14265" checksum="AD7E88F8CE15AF2E" modified="2017-01-18" version="1">MSTVTVSRPLAFPQLTLPTADDHSSAYAPPPAYEQKMQAYRESIDVELRDYDACKCQELKEWVEAWEMITSDPKERERIRPYAEAEFASEREELVKGLESDFQHYSKVWLLEDMALASAMNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUQ2</accession>
    <name>A0A1E3HUQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028162.1">
        <property type="nucleotide sequence ID" value="XM_019179858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUQ2"/>
    <dbReference type="GeneID" id="30197088"/>
    <dbReference type="OrthoDB" id="10275726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="390" mass="43913" checksum="3E9EC7B3667378A2" modified="2017-01-18" version="1">MPPSTANTDTSSPSTTPPLFPAEVEHVIYDNFLSFDPSCTLTRTLTLAKLSKSHYELFIPRLYQRIVVSDKTIERGLFEGLSARPAGGTEVVRAEGGPLGSKRDLLEHCESLVFVTLAARDATAEVVELWNGVMTAERYEAGGLPDTPGIFNNVAHIAFESDCLEQYAIGKLDLLFRQQAPAIKRHPWPLKKLSHICFRLPYPSLPSEYEQYLESLYHLASYFAPGVHDTVGNVTRFQNHDMSEDSISSINYVNWGETMIVDMLPLEHSEDSGGVEGYGRHVELINTYCKKSFWIWGQFGKKCPEDLPKALILTNFGTTVSRDGNFHYISSNKQKAILQKAQKDIRTRLQSVAASENLDTGVVDKIFIRGHEECEFCGDVCPKEYEYWDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HVH5</accession>
    <name>A0A1E3HVH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000043">
        <property type="protein sequence ID" value="ODN80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028228.1">
        <property type="nucleotide sequence ID" value="XM_019179806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HVH5"/>
    <dbReference type="GeneID" id="30197035"/>
    <dbReference type="OrthoDB" id="2567950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="72003" checksum="F7ED557C3E5D9739" modified="2017-01-18" version="1">MAPTFVDDHITPRKLTNLEIWHAWEHFDQLPKDVLYGLNDFQTPSMYPPLRLTYYRTAPAVSADLHSLRLSKMAIWEFFERLKNPFGDDPTMGGMMFRMSFQGVKYGESNNLKAQLDKVEAKREGANKLYRQGKFQDAMEEYTKAWKDVLPHYIESLSETDTQRPRLGYFEAVLFANMAATCIALAKASKTVKQEKGYLRMAFQCAWVTWEMRDFAAAITVRNATLRFSDVLRRLYQNSKSPYQDRHFEQMAAYFSGQAEALEGVNKEQLFKDVEESKRLTPPPIEALQAFGPRAWAQRWIKHLPGTSSPYILPPPPVSTLEERKKPRDLTPFELWAAWDEMPEEHREDLNETKMPLYHLQTRLTHSLTTPAERTALHYLRQAKFHVFRTVMSTAAGDSEFDAIVKMIKDKPVDQPSLEHKLAEAEMKKAQANKLYRKKEFPNAFAEYFFAWSVVLPYHTDALPAGDPLRIRLGKFESALWCNLAATFIAVSKDPLEEEAKEGFRDLACKCAWASFAERKYATVNSVKHACLRARDTFFDQSSQSGPSFVMTGQQPDASEPGTITKFFSRQAEKLEGLPKDMLFADVEASRKVKLPDAEVWDKYGPQMWLMAINTKEMASKPFTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY96</accession>
    <name>A0A1E3HY96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028249.1">
        <property type="nucleotide sequence ID" value="XM_019179768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY96"/>
    <dbReference type="GeneID" id="30196994"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="5">
        <location>
            <begin position="265"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="42493" checksum="CB3C0B8A8528D26D" modified="2017-01-18" version="1">MTMSKGMRRSVLVIGTGGTIASELTENGLAPLRQDSFFRRIRQHPSLASPASPSLTSSSVSTPNDLSFHSPVITTKVGKNTKYPKLVTPEMDDEGREVEYEILDLDRHMDSSEMTPAEWNTIAGLVSENWKGYDGFVILSGTDTLAYTAAILSFLFANSGKPIVITGAQIPLSRPRSDGWTNILDSLFVAGILPYAGVGIVFNHQVFRGTRATKTSPNLFAAFTSPCVPAIINLNVKITRDASPLPPRSLTPPAPLISLKTDPTVLSIHIYPGLSGSLLSAQIAAVPTCRAVILSAYGSGNLPLDPSNGVIEALKEMVEREIMVVVLSQCAVPNVYPLYTQGRMLLDLGVLPGYDLTHEAAFAKLLWLVSDESLPFKEKQQRFEEDCAGEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HYP6</accession>
    <name>A0A1E3HYP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="1">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028246.1">
        <property type="nucleotide sequence ID" value="XM_019179765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HYP6"/>
    <dbReference type="GeneID" id="30196990"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="648" mass="71851" checksum="6377057E0EFE6A8A" modified="2017-01-18" version="1">MPNNQVPNSPTSTSFSGTFSPGATAANTAANANAKDSSPSTPESPVMGQRADGKEQRLIVVSNRLPVTISKDANGEYHFKMSSGGLVSALSGCKKSMSFIWIGWPGKDIPMADREHVNQRLLEEYNCLAVYLSDELADRHYNGFSNSILWPLFHYHPGEMNFDAENWLAYREANMRFADTVSSMVQAGDMVWVQDYHLMLLPMLLRSMITGESAQGEMVRQELGRVKEGVDDSVVKEVLKMDPGVSEGVADEGVELLDDVEEEGGEATHAHGKPHFSRDMSTFQKQEAVAKENGKEGVRIGFFLHTPFPSSEIYRILPVRREILLGVLQCDLIGFHTYDYARHFLSSCTRILGLETQPNGIEFEGRYCQVGTFPIGIDPHQFTEGIQKESIRNRIRQMEARFEGCKVILGVDRLDYIKGIPQKLHALEVFLTQHPEWIGKVVLVQLAIPSRQDVEEYQNLRACVNELVGRINGRFGTVESMPIHFMHKSVPFEELTAMYALSDACLVTSTRDGMNLVAYEYISSQAERNGSMILSEFAGAAQSLNGSILINPWDVQSTADAIHQSLTMGPEQRSSNWQKLYNYVSKYTAEAWGVAFVKELTRLSGQRPSGPAVPAGRRRSNGSSSRTSSKASTKRRSVASGVQSSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I168</accession>
    <name>A0A1E3I168_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07763</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028298.1">
        <property type="nucleotide sequence ID" value="XM_019179751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I168"/>
    <dbReference type="GeneID" id="30196974"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="14">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="786" mass="85691" checksum="A0FC2FF1591C0B2B" modified="2017-01-18" version="1">MPPLVRRSPKAALPTLLSLSKLVGLVPRAAQQWSAASGNAPIEPEDPPDSPVFWWKLGLSAVLVLAGGCFAGLTLALMGSDDLNLRVLSTSSTDPKERQAANKVLRLLSRGRHWVLVVLLLSNVIVNESLPIFLDDVLGGGLYAVIVSTTMIVIFGEIIPQAASVCVRYGLFIGGTCAPVVWAFMILFAPIAWPTAKLLDYVLGTDEGHTYKKAELKSFLQFHREGEEPLRDDEIAILNGVLSLNDKHASEIMTPMEDCLILPADRVLGHEAIDEILLSGFSRIPVHEPGQKDNFAGMLLVKKLVSYNPEDEWPVSKFQLLPLPEASPNINCFQALDYFQTGRAHLLLISDTPGQKGGALGIVSLEDLIEEIIGEEIVDETDRYEDNHSKKAVKRAGTAAVMRKSSHFHHQRGIIERRRVLNAFSRVPSRGESQTPQVPPGGPSSSDGILVQINDGALVAEPVGLSENGANASVNPAKRLVISTPASGHMSPITEGSSPDAVIPELAKSLLKAEENAQANGEGNGTRVTRTLDERGQTEMFPDHRAFEKACRAMVSKYQHMTGTLGPQRTNRGWQWKEHKWMPNQGYLYRHLTCYVSPSSLSSESQPLATDSTSERDLEEEDMEEADDTALLAGEDDKPVKVDIEQHIVFSATYRVPMYCFRAWDETGAPLSIASLLKLNILHPDTPAAPLQFGEYGAALDTLMLPPDPSSPMTDEQGQQPFPLVQSTEHPTTGQLVFSVHPCKVGGAVDEVLVAECKDQCGDGGPLAWLEVWMMLTGRVADLRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5B7</accession>
    <name>A0A1E3I5B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRN6 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028371.1">
        <property type="nucleotide sequence ID" value="XM_019179683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5B7"/>
    <dbReference type="GeneID" id="30196906"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="229"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114316" checksum="57C4FEE3AF3EB830" modified="2017-01-18" version="1">MAFPPSVHHLHLPRTKRHHRAFQEGSQEDELDPTQPSQSQLRKGKGKNSVYKDDQRGGITDDVGVGGAVGGFGKQAGVRLDRDKRGGWGWNWSLEDPKGGTKEGRWSTGKAATYFPGTISTETEGMGMPFEDVLQSSVQYAESLCLPYERDGLRDVITEILTEDFPSAGPSGTSKQPGWPHLDLDLNPEMNKKRDVYRGARVVVVQNPKGRPARSFVAFPTGKVGHQLRDATALIVRLQTTTHLLNIHPLSSTPSPFSSTRTAQLSYVDTESRKHINIALDAEIWSRALVVDEGGGVWLWWEEKETKGGRLEKVMKLRKVREAVEEEEEEGERFWGVAFGTRPGTAIVVSAREATIIDIDDPDHPTRSLMTLNGPTRRFLGIERTAAARGSKWTVMCTTHEVFWIDETGKGVPSLGWKHGYEGADGMEIIVLPGVNKGECTTLLYSASDSFITVFTTPKSGPLRFIGQPYALSLNLPPESIPTTLTSLSISPNRHLSSLLGLSDDGTLSYIPLSATTPLPPSAEKQKPLEPIPTSWDDTVSELAKKDDRNEFGAGDGWEEKAKVGFRELNLRWAWLAIGKDDDGSDSGENSEAEGLDFAQADIEEEDEDADVQMMSDGEEGQWDDDESEVAEERWFVPELFERYLRETEAPVESVMTVAELARDSLVPFSEPERAENGQEKEKEGKVSKILPIPLHPSSIRPTLEALGKIDFSKHLTSLLDLQSFLPALASAQPPLSKDDIDPVTLYDSLCEAFPPQSARDKHATAQLVLSLFLFSKVISPEDFLPIPKSAHDQALEDEQAEVQRRDEVEQFVQAASRLTLDESGPGRIQFNVLQPRLTLRGEDAGNGEEEWADEEGEEAERAAVEADLQSRSAKALMEGWKVGEDPATWVWEDWNLDQSHTTPFPRATQSSTSQRAPPLPTIQTARPIRPLPSSRTLSNLALPSPNTPEPHQFSHLVPPTLSTSHSLPSLSRMPAQARSSPPPGWDGGGSQELSGAGQIQSQSQSQGAEWASTQVERGKFGGKLEKKKKSKKRLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I810</accession>
    <name>A0A1E3I810_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028406.1">
        <property type="nucleotide sequence ID" value="XM_019179638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I810"/>
    <dbReference type="GeneID" id="30196861"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="63236" checksum="275424DA8A42322C" modified="2017-01-18" version="1">MSGIPPIVDTVNVTNPPVPQAHSPSESIDDKTDLSGSEKDGVDPLNRTYNESVDSVELKFYEPPDTYESKHRWDPRAQWTIEEQEKLRRRLDIRVAAFACLCFAALQLDRGNISNALSDGMLTDLNMTTGDYNTGMTIFYCCFLFAELPSQMISKKLGSDIWIPIQMMTWSAVAIAQMGLHGKQSFYATRALLGLLEGGFIADTVLFLSYWYTAAELTIRLSWFWVSYTAITIIGAFLAAGLLEMRGIHGLAGWRWLFMIEGALTFVVGFWAFWYLPASPTQTKKWWRPKGWFTEREEIIIVNKVLRDDPTKSDMHNREGLSLKQLWFSLSDYDMWPIYLIGITAFIIPSTVQAYFTLTLTSLNFTTFQTNMLIIPSNVLFIIFNLALAFTSRKLKERLLTSSIQPIWHLVLLIALVTLSDDASRWVKWAILTLFMGYPYCHPIMVSMNSMNAGSVRTRTVSSSLYNMFVQAASLIASNIYQPSDAPYYHNGNKILIGLSVASIALFVFAKLWYVWRNKQRDKVWDTWTVAEKAEYLATTSDKGNKRLDFRFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9F3</accession>
    <name>A0A1E3I9F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028451.1">
        <property type="nucleotide sequence ID" value="XM_019179594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9F3"/>
    <dbReference type="GeneID" id="30196814"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25164" checksum="FB42E0DF519ED629" modified="2017-01-18" version="1">MPLEVKTILVTGANRGIGLEIAKSYLDKGWKVVAAVRDVGKMPKLEGDLLVLKIDAAYLTDAQEAAQELRTRHNIHDLTILLANAGVGLMGPTLAQTPVASFEESIQINTRGPLLLYQAFRDILGDGEGKTFAVVSSKGGSILTPKRIGFGVYGCSKAAVNFLVRAIHFEETKLKAFAIHPGWVETEMGIMASTKANMNGTTPQRLEYTVPGIIRLLETTTKEEHSGWMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9K1</accession>
    <name>A0A1E3I9K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028424.1">
        <property type="nucleotide sequence ID" value="XM_019179567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9K1"/>
    <dbReference type="GeneID" id="30196786"/>
    <dbReference type="OrthoDB" id="2596840at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="39747" checksum="731941F38B4D835B" modified="2017-01-18" version="1">MGPGPIILGGIAIVGTGYAFKKFVYDPHLAPLIEAAIEEARHRSRNHHFPWEIRPQPHAQHTGHESEAIAVPVSASTTALSPTHTTLRRRSVHKNIDDFEMGSRPLSRSVSGPGLEKQGPSDRRGWDGEEHDPFLDPPSYDTARIYQEQYHQPSSSASMPLGGAGVGASEKPLPGRSESAQDAEIRSLLFDAPDPSPFQGQEGVPFMAICPPHPSSFLPHHPNPNPNPNSPSSSSAGAGVLSDEGAAPSTTFSFLSLSPSQLPSPQTPARTINDLSSASTPAPASLLSPSTSPPSSTFTLPNDLAPTDLGLTFIHPHAQAPSSTFSSASDSAFGSPRRGPLSVVSMSEESEGGEVGEGGRGDSEWEEEDGWSDAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9Y0</accession>
    <name>A0A1E3I9Y0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_07540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028480.1">
        <property type="nucleotide sequence ID" value="XM_019179534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9Y0"/>
    <dbReference type="GeneID" id="30196751"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="312" mass="33753" checksum="08507D318657B9FD" modified="2017-01-18" version="1">MASAAYSTIKLFSGSSHPELAALIAKRLRIPLARANIVQPPSGETKVTIVESVRDYDVYIVNTGAGSIASARRITAIIPHFPYARQDKKDKSRAPITAKLVANMLREAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSMVQYIRNNIEVRDCVIVSPDAGGAKRATSIADRLNVDFALFHKERKKANEVSRMVLVGSVTGKIAILVDDMADTCGTLGLAAKNLLEAGATKVYAFATHGILSGPALKVIAESGMEKLVITNTIPQSENCEQCEKIEVIDVSRVLAEVIRRSHFGESVSYLFHEVPYSNGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBW5</accession>
    <name>A0A1E3IBW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028635.1">
        <property type="nucleotide sequence ID" value="XM_019179387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBW5"/>
    <dbReference type="GeneID" id="30196596"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN86092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="48232" checksum="CD3F410E4A78100B" modified="2017-01-18" version="1">MAEVIGLTPVTSQFSQQATETARGSSALAEQQQLGDEPESASALPPVDTGRRAWLFLAGATVIEIIVWGLPFAVGILHVYWTNTLFPGYGASTITLAATLQTGLLYMSTAFFGPIMAAFPRYQRHFQILGLSGACISLISSGFVTKPFHLVITWGCIFPLAGSLYMPCATLLFEWFFERRGLASGIMYAGTGIGGTVFPYIINSLLSSVGYKATMVSIGVAYAIIGGIALIPTTRRVPLSRYGSGEPGPRRQGLSLGFMKSFTFFMGIFTILFTSLGNFVPSLWLPSYADDLNLTSPSGTALISILNAASVPGNFLLGFMSDHIPLQIVISISCIGTALSCAFLWGWGTGGGTLVGFCIVFGLLGQSFTALWTQMIVYISKDDPLASPLVFCTFAFMRGVGNITSGPISGALLNISALRGATGAYGFRNYGILLIYTAVTILLGAVTGLLFKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID72</accession>
    <name>A0A1E3ID72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028755.1">
        <property type="nucleotide sequence ID" value="XM_019179274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID72"/>
    <dbReference type="GeneID" id="30196477"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN86572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="697" mass="77999" checksum="FA22C6A245C8DC42" modified="2017-01-18" version="1">MIEPVVPLGPFKHGMAWVAYRFTSTVLDDIWPGVVFFTGVAVMVACVSEFTSVNLGINSVMLTVLGTIVSLVVSFKTNNSYSRWWDGRNGWSNLTTHCRQLATLIWIHIPNAPAPKPDAPKPEPAQPPQTPDAASKSGKSPFTPNSTAQTLSPSSVAQESEEDVSTGYHVHGWRTPAQEAEAKKRFEDDMAARNDQQAREDMRGMIEKKTYIGLARLSHIQAFAVSMKHALRGERGPFYSDLYSLIAFLPKYNPASHPPITRDHLLALWQNGIPRQKSSRATDDIAVPLTVPIAFTSDALNQPNLPNPFDDEEKRIGEQVYGPAPDDYKEQAVRNASEYVGTDDPEVFVVTSKRDGRKSITQRRSIQVQGRTGQGGEQVTLETIELMPPRHPPPPRIWDFLPPLRIFKSIYDMLNWKKKKEISERAKGGKRRRSAMGTDMQIPQEILMYLSMYTADLTRRGLMPGPLTTAFANAILELQRAISDMEKIATTPIPSAYTFHLHLTVYAYLFFIPFQVYTYIGWVVIPATAVASIIYLGFLEIGMQIEMPFNYDQSDLDLDQFCLRIAHQIAQLTAFPTNIPSQHVILSHLNQPFLPTLRASAPDILGVPERQPMPNPRGFASSFSTYDKPPPSSPSSSSTEAQQRKPEVKQMQKSMRDVELVLNANWKDVTSDARNVIGKPRDQLENRTGLEVAVLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDV4</accession>
    <name>A0A1E3IDV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028796.1">
        <property type="nucleotide sequence ID" value="XM_019179179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDV4"/>
    <dbReference type="GeneID" id="30196377"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN86804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17990" checksum="D3AB376FC878958A" modified="2017-01-18" version="1">MSLWLHGEEDFISEAGAMNVFLLKEAKDGFLEFVTTPLSSGIVLPGITRASLIELLTDHASGKVDFPLEGVPKNIRIVERDISMGEIVEGLKDGSVKGMFGCGTGVVVVSIQHITYSGTPLTWLGTSPSRPAQRGRIADGGRGWAVEVPEWQGAGVAEKEGGREEVIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IES9</accession>
    <name>A0A1E3IES9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028874.1">
        <property type="nucleotide sequence ID" value="XM_019179116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IES9"/>
    <dbReference type="GeneID" id="30196313"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="93"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="416" mass="45640" checksum="8C9EC8F4966D60DB" modified="2017-01-18" version="1">MARSTPKRERSQDKPAPAKKPRVAKGKVWPPADIEPSLHPARHGHPVFELPALTTSPNGGIAPPSDRPQPMLLGAHVSSAGGVGTALLRAGLAGANGLAFFVKSQRQWKSKPYEDEVVDKFRELMKSKEEGGMGYGPESILVHGSYLINLGNPDQAKWETSYECFRDDIARCHQLGVKLYNWHPGSTVGACTKEESFASVAKAINQVHKDVPEVITVIENMANAGSNIVGTAWSDLASMIALVEDKSRVRVCIDTCHTFAAGYDLRTEEAYKKTMKEFDEVVGNKYLAGVHLNDSKADLGANKDLHENIGLGKIGLTAFRLLMRDPLMAGIPIVLETPAPDGPTPSDHVSIWSKEIAMLYEIQAIPDDEWDTKKVEIEARWRKERDAINPPKEKKKPAPKGKAKKGKKAESEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHH6</accession>
    <name>A0A1E3IHH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029115.1">
        <property type="nucleotide sequence ID" value="XM_019178838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHH6"/>
    <dbReference type="GeneID" id="30196001"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="291"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="59283" checksum="5004AAF83083CD7A" modified="2017-01-18" version="1">MGLASKLAASNQAGVGAGGASGAPAFQQQPQQAQQQSYGQPQQQSYGQPQQQQQYGTSSPAPGANQYASPSGAPPSQYGQQQGQYGQQSQYGQQGQQGQYSAPPGAPPVPGSRPGAAPGQTQFPSASGTPSQYGQQQGQYGQQPQYGQQQGQYGQQGQYGQQGQQGQYGQQGQQGQYGQQSQYGQQGQYGAQPGQHLPSQQYGQNPPAYGAPGVGAAQPPAQGGNNQNPQYLLSLLQQCVVDQNIQAFYPPGSLEPIANRVAQSGALNKIATEWKIPTELAADLVKLSLFDVILYIDDSGSMAFEGGGERIDDLKLVMSRVAFATSLFDHDGIQVRMMNSRVEGNGIKSEPDALRLIDQIKFSGLTPLGTGLWQKILQPLVLGPAQQNRLEKPVVVITITDGTPAGEPKDEIFNVILRTDQELKRTRYGPDAISYQFAQVGDDLKAQAFLEQLDVHPVVGGLVDCTSNFEAEQAEMLRKSGINLDPSMWIVKLLMGPIDSSYDTKGEFAFRFSSAGEEEEVPFEHSSTREGYHHLSSSLAFDLHLLEIGLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHP8</accession>
    <name>A0A1E3IHP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EFM4</name>
        <name evidence="5" type="ORF">L198_06804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029126.1">
        <property type="nucleotide sequence ID" value="XM_019178849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHP8"/>
    <dbReference type="GeneID" id="30196016"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000624">
        <property type="entry name" value="Protein-lysine N-methyltransferase EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="245" mass="27745" checksum="8E8FFC08CDED2BE9" modified="2017-01-18" version="1">MPVEELPPSKLGTKEHWDSVYEREVRVFDDCGDEGEVWFGEDSVRKMRKWAHTNLPSSSTTLRVLECGSGNGTLLLSFLTSPEPPARSFHLTGIDYCLSAKTLAESVEKSRREELEDEDDLEDEEVVNEVTAEWRVGDLLRDDFKGEIWDLVMDKGTYDALCLSNDPVEEDERKRLPSEVYPERITKLVKPGGFFLITSCNFTEEEIKERYGKEDLGISSVPHPTFSFGGKKGSTVCTVAFKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIR8</accession>
    <name>A0A1E3IIR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029292.1">
        <property type="nucleotide sequence ID" value="XM_019178809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIR8"/>
    <dbReference type="GeneID" id="30195967"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="62156" checksum="6B7E61DDC5A5FABE" modified="2017-01-18" version="1">MSTPEKNQGVFSLEDEKLSTEHIEVAPSATNYDGAEKGLPARKKRTANNQIDDAARLLEEAGGHVDYTTEDNKRILRKIDLFVCLPMCLVYFIQQLDKSAVSYAAVFDLRTEANLHGSEYSWLSSVVYCAQLVCQPLSSYALIVLPVKYWVIFNMTAWSIVTMCTGAAKNFTGLLLARMFLGVFEATIMPSFILITQMWWVRREQSYRTVAYQISNSFAAILGPLLAYAIGKAVEGSTTVKPYQGIFIFMGGISLALVPFVWFMMPNSPTTAKFLRGGNDRLIAIHRLKDNNTGTKASKFKWDQFWETYKDPKTYMWAAMWLLCAIPSGGIGAFGGLITKGFGFDTFTTILLQMPPGGIGIITILVGIYVTNKIKMRWPVIATICIFPIAGACALTQVPNSKTGALMASYYVAYLLSAIQPLLVSWCNLNCAGTTKRVLTTATMFGALTVGNIVGPQVYLDRESPKYHTGLYVDIACWCLLLLLVITMGFYLKVLNRRQEARRVALGMPANLKDVSIMNTEEADRYRAELKEMMRARGQGTGTGQGELNEGAFDDMTDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ69</accession>
    <name>A0A1E3IJ69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029094.1">
        <property type="nucleotide sequence ID" value="XM_019179000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ69"/>
    <dbReference type="GeneID" id="30196192"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="69692" checksum="374235897531FC26" modified="2017-01-18" version="1">MTEQHGDDVPPPSAPRQPETGRKRTRQVLVCMRCKSLKLKCDLEKPCASCKRANLKDGCVYKPWPSEDDIRPAKRKSRARRGSLSAHSSEHRAELHSPLGDRMEQLENTVADLVSQLHSQHSPRPALAPPAPSETQWRHLLDMLPPRDICEDLLDRFELFDIMFRSTHMPSFRRRATCILPGALSIGVRCPPSRSAVDLASPTIFPSHLDDLYRRLVSFTENKSDTKHITLDYVHALSLEGWRSMYDNDMTVAQSWILSGKVANAALFLKLDRDPSELGQAMETFEAEMRRRLWWQVVISDTFVTKYLDIPKSMISLIATSTRMPAAIPDISLEPPNPSLESGIPEWSYINSKIAFTSVLARLGEIKQSHGTVLPREDLRQCISIIDTYEQNLEPHLRANRGAVRLEPPWVYAQACVVSMGSCNTVIQLCQQAMATRLPDDRAFALSLAVERSRSLVTTARAYVDHRLFRWPDCPPLNLWTFGSKVFNAGIMLACSLLSSPRDPGFNLDPDQRLELVDMAIGALAFSIQENQGETLNERALKTLRTWRSKVANGGQELGSGEGLLNPYTGQGVSILEGKTGAVAVEDVWKSFSWDLQYLELFDWSTWLASMMTDACSTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJU5</accession>
    <name>A0A1E3IJU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029346.1">
        <property type="nucleotide sequence ID" value="XM_019178645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJU5"/>
    <dbReference type="GeneID" id="30195802"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="101" mass="11430" checksum="89DED272F6DC8081" modified="2017-01-18" version="1">MSSRTNKATMHELKLRRLLEHNHRLREELARPRVMVSVASMNLINHCRSTKDPLIPSVWGPLEKGDDPYAPVDNGNCCSRTSFIPTARLPGLPLLSIRMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IK02</accession>
    <name>A0A1E3IK02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029406.1">
        <property type="nucleotide sequence ID" value="XM_019178705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IK02"/>
    <dbReference type="GeneID" id="30195862"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="20992" checksum="0A3689A6C7C8E0BD" modified="2017-01-18" version="1">MSSLHDTLEAIRRVGVFPEGAEEIPGVAVQPGFAVQPGVAVHDFGAVDNIRPPREMGEASRDIRSLFEKGSGQDITRSPLGSKAWDIDVNYSQNCLAVSSEYTCGMTKSHKPSVAPLGVDPSSTKSPGKLPEDGYIEAIAAAAQLLEAGPESAMKDSLFSYYTPSGHHASIGKRKNHMRGADWLISVGKSKVSEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKP0</accession>
    <name>A0A1E3IKP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear pore complex protein Nup98-Nup96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029452.1">
        <property type="nucleotide sequence ID" value="XM_019178545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195702"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="937"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1085"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1921" mass="200548" checksum="50AD1F28E0A0B79A" modified="2017-01-18" version="1">MFGGTSSWGQNNQQNQQQQGGGLFGGGGTGGGFGQQNNTGGFGQQTNTGGGFGQPAQNTGSVFGGGAANTNTGGFGKCGFGGANATQPANTFGARPAFGATGSTFGQPAANTGGGGLFGSNNTANTGFGAPANNTGGGLFGAKPATSTFGSGATSNLFGAKPATGFGAAPAGQDGLKGPNELQQYRTDAPPPPPPSTGTANPAYYPTWQADPSTNTSLGKEGPPHLFHSVSAMFPYRGASWEELRAMDYQQGRKEATPQQQQQQNAFGASSGGFGQQPAATGFGAQPAATGFGAQPAATGFGAKPAGTGLFGSSAPSTGFGSTPAAGGGLFGQSQPQQQPQGSSLFGGQSNTNTGGGLFGQSQPQQQNTAGGLFGSSTNNSSPFGGQQNQQQQGGSTFGGFGQAAKPAAFGSTGTGGFGSGSTGSTFGQQPAANTGTTGFGGFGQTQPQQQQQQPAAGGGLFGGGGFGANAQQPSTGGGLFGSQNSQQQQPAATGFGAAPKPGGLFGNSTPAPASTGFGGFGQTPAAQPAAGGGLFGNTGAAQPSTGGGLFGQSQPQQNAQQPAAGGGLFGSASTPAAGGGLFGAKPATTTPSTGLFGSQPAQPAPSGGGLFGNAGASTGGGGGLFGSTNNNAAGQPGQQQQSGGLFGAKPAGSGLFGNTGAASTGGLFGQQPQQQQQPQAGSTGGLFGNLGQSQPASSGLFGSTAAQPQQQSTFGGGSLFGGMGQSTAQPQQQQQPSLTTSIDQNPYGNNPLFAYNGQKLEVGSQSKKPALPPLTASSYRLTPSTSKSKLNKLRGFASPLTASQSTPARAGSPLSVSSPGKTSLFNSPVAPDRYKGLSDTALTPNAFVPRPNIKKLSVTPKLGGSLGGGDQLESVLGKSALRSSTNSIPGSPAPRQVPLVFHPTANATPRPESVASPRANGVDSPRLAGSERPPKKGDYWCRPKLEKLKQMSTDELSALSGFTAGRRGFGEVTFLEPVDLTRAPLDDILGAIIVVDQSELSVYPDEYPDKPEMGDGLNVPARIMLENVFTTDKATKEWVRDPQDARFQKFVRRVKAIPDTEFVSYTDDGTWTFRVEHFTTYGIGDSDEDESVASGSNGARDSSLSPSGSEDDEDMMPPVKSIRDLEGQHDSGLSEDEFTGESIADDFDGGFTDMDTSGEFDLPSHPSIEIPLKSHLGPEGMRNLKEMQSSFFGSSAPTKRPARELVGSRKRGAEQGSFFREAEEENMMLDQRAVKRTSFGELPVSLPIIRQKRKYARVAVDESIEKGKEGINVDAGLALGRSWRCSWGPNGELVHLGKICGPRAKTFCNPDAVVNIEKVEILAESVNVEKSKAERLLALHLETSLVEQIEGVPVATVNPDIRFGDFASRFDAGDRSHEANVFRLGVALFDEIDLRLPEDSSEELVHRITSLRRKLALSKWLEDAVASSVDSDLITNSDSRPNKLFTLLSGHQVERAVEIALEGGDMRLATLISQSGGQQTFKDELLLQLEDWENHKVNPFIAAGYRRIYALLAGITDVLKGSPPGRASEKWPQVLIAEGLDWKRAFGLHLWYGMPFENTVSDVVSSFANSLSAANPPAKPLPPYLEKPSEGVRSWTLPTEPTDVIYNLLQLYSDDAVSLDQTLRSRDTSSSPFDVRLAWHLYILLTRVFSRRDFEDREEGYSASADRLTEGYAAQLEESGEWKLAAFVLLHLETVEGREKSLRALLNRHPDVTADDTSFLVETLRIPAEWIHAARAAAFTSSGDAWKEYHALLEAKLFDRAHRVLLERLAPEAIIRDDRALLKKLCLKLEGKGVAGWEFGGKLFLEWNEISEDTAPLLVSVLRSGSQPDPRQVVELNERAQALPRLLQLLPSLFSDRNDVQQVAGLSEVLSPLADLASALSGAGYIAKQPVSANLVDEDRLHLLRESAFEAFNRTLAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKZ6</accession>
    <name>A0A1E3IKZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette, subfamily B (MDR/TAP), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029473.1">
        <property type="nucleotide sequence ID" value="XM_019178566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195723"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001982">
        <property type="entry name" value="Serine protease/ABC transporter B family protein tagC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1332"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="252"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="624"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="952"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1670" mass="183068" checksum="FD20201AB451A9D0" modified="2017-01-18" version="1">MTATHTSSPSSPTPRTPRTPRIPRTSDVPDFPYPPVRSLVTPTSPPGRLPSTPRQSSHEYPQSPSSPSSTLRRAAGTSLPLSPSSGLYYSSPPSTYPNIHNTLRNSDEVELVALTPRQLPPSVETQDESPFHDRHSVMSEREDLFEFESGRQRTMPGYKFASLSPPGTDERGQPMSFGPMLDQVSRPPTDWRRSLYPAEPQSIPTYDYPGLPTPSSPTSSRYSLLPEAVRPRFRRLFTFTTWRDYLFVFVPGVALSIVAALIQPYMSVVIGDAFEIFATYPMVMSAVTETDKQTLKDGVRDTCIKLTIAGVLALVLDYCKGIVWTLYGETVANRLREKVFKGVQDKSMKWYDMGMGMREEEQGEGKENDAVGAGGLMTKFNRETDDVRLATSLSFGLVVQDSFTFLLCFILAVVYSPKLAFVTLSTIPLIVLTQIITQVTCAPLLATERRVLAEASTNIERATGAISTVKVHNAQSAEETRFLTLIGRGMGTMIKQGLVWGISIGVTDFFLLGTFVLGFWYGAQLIRNGSATSGDVMTCFWACLFAATYLQQVIPHLTTLTKGKNSMASLLTVIQDEPVRPVSGNPFSPGSTPTTANFNIAKQPKVKGSPTFEGLRPNKCHGEFNFTHVSFSYPSRPDNLVLRDVSLFIPPGETTFVVGGSGSGKSTIAQLLLRLYNPLTGEITLDDNSFDFLDASFTRENIAAVQQGCILFDMSVHDNVAMGLAGSGPDPKTGIKRSPKDVTREEVVDACKMAMIHDFVVGLPEGYETKLGTGGSSLSGGQRQRMAIARARIRDPTVLILDEATSALDATSRVLVFQNLKAWRNNRTTIVITHDLSQIVSDDFVYVMKDGIVAEQGFRLDLVKKTGGVFANIAAEQAITPFPAKDEGDEQWRENLENLLDMEEDSEEVLDVRSATPAFSKLLNRNSGVYNDMYDEYSRGQRLSHLDRPRSRQSTAQKRLSWTPEQHGRTQSRQAFGASGGSRPVSRNSRPASRMDVSPRPSSRMSLKTMMADPDSTPRQGNRSQRSLELPSSGMLHAGWTEKSSPGQISLRERQKKTLSENLEDDLKDSVSELDNPHTAIEVESEGPKPIPGTFALIKLYFPTLPHKYLLFFGCLGSIGHGATTPVWSYFLAKLMTIVGAGGADVGALTKYGLVVLALCACQGLCNCVQEYSLVNLSAQWSHMVRGQAYHKLIKQDKAFFDLSPNAPSRLVQLLIKDADDARTLMSHVIGKAVTVITMLGLGIFWAMAVEWRLTLIGLALGPIFGGCMALNSWMLGNVEVACKAAREDVGRVFYESVANVRGIRAMALEGAFEDRFATGAKAAKSIGKRSAWNMAIGGAIGGCLPLFAQAVMNFAGSEFMIQGRMNYEEMLQVYNLVLFSLTFGAGLLDFIPMMAKARVAARDFNRLLFLGEQTTESEGELRMPINGHIAFNHVAFSYPSRPEVPILTDVSFTLTPGECVAIVGPSGSGKSTIAALMQRLYMVDAGEIRIGNYNLKQTDAVWLRNHIAVVSQSANLFDASIAENIAYGTPNLPLSEIYRAAQAANIHDFIQSLPQGYDTNLGENASLISGGQAQRLQIARALCRTSRILILDECTSALDSDNAKAVLDTIVKIKAHRTTVFITHSVEAMQRCDRIICLGEGRVEEEGTFEDLVRRGGVFAQLMKTGEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILE5</accession>
    <name>A0A1E3ILE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029324.1">
        <property type="nucleotide sequence ID" value="XM_019178623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILE5"/>
    <dbReference type="GeneID" id="30195780"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="81" mass="9064" checksum="DE26C12B96540E3F" modified="2017-01-18" version="1">MLRSRQAKPFSQADQGLNLTATFPSEIYFLDTCSPLVYKHVTLNEGNADNFFLGLADGKMKKGEMQQVPDKRVLGDITWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILZ6</accession>
    <name>A0A1E3ILZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029528.1">
        <property type="nucleotide sequence ID" value="XM_019178372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILZ6"/>
    <dbReference type="GeneID" id="30195518"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17666">
        <property type="entry name" value="PTP-MTM-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="130"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="362"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="828" mass="91558" checksum="02B69AB500B45D15" modified="2017-01-18" version="1">MDALRVARVDDVAIELPQPPQDTAARITGDLHLTPHHLIFSQSAPSTNPHPEIWIPYPNITLLTRLPQTIYGLYPVQIETKTFESYVLLFNKDREGGAEDVWQSVKDCTVKNSVEQLYAFFYVAPSPGKGWQTYNARAEFARQGLGTRTKAWRFTDINKDYSFSPTYPNKLVVPSRISDSTLSYAAKYRSKARIPALTYLHWANNASITRSSQPMVGMKNSRSSQDERLIECIFSSHHFLDNAYSSTSTPIYGATSTNLIIDARPTTNAMANVAMGAGTENMENYKLGKKAYLGIDNIHVMRSSLKIIAEAIREANARPTIPLDRGLLRKSNWLRHISTILDGALIIIRNVHLNASHVLIHCSDGWDRTAQLSAVAQIALDPYYRTFEGFKILVEKDWLSFGHKFLDRSGHLSSEKYFSVTEGEDDLEEEGPGGGAQRAAQAFFASVQKQFSSTSHLKEISPVFHQFLECVRQIQRQFPERFEYNEQYLLDTYRHLYSCQFGTFLFNNERERQASHSGKPYVERTASVWDFIEQPSERAKHVNPSYDPSLDKSDVTSGTPEPGDQGVLLYDPKDVKFWFRLFGRGDEEMNGSPVSLAAGVTGVDSSSTVTGSEDNPVRVEGIVRRVTPVGAPPTDPLSVHATPLSPEPATSSPGPKSWNWSQISGTAFNAVQSAARDFRTISTDAFAQIKAEADELEKHGWGREDGRKRLGSGVTRDSGPVAPSTGLSRMGLRVPSEANPWASESPRSPPLSSPARPDLAPSIPAVAVRPGPSRTTSNPWATAPTPIPSLSGLSIEDGATNDAAVQENVEATKIRKDNDESWDPLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INN7</accession>
    <name>A0A1E3INN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CMGC/RCK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029742.1">
        <property type="nucleotide sequence ID" value="XM_019178304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INN7"/>
    <dbReference type="GeneID" id="30195450"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="933"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1250" mass="134794" checksum="2A9D356A73AF5ED8" modified="2017-01-18" version="1">MSDFDIYREPSHSHALYREGSNQTTTSSYHLPTPDSMASFQHQQQAALQRLQQQQQAQTQAQQAQVQMYQQPVYGNGGNGAFNRRRQESEDVEGDGRVGVEDPRQDRQYTELKCLGDGSFGTVWLCDWHSGVTPDVTLSAMQCGAGARPEWSGKRLVALKRMKRVWENGWTQAKTLGELASLRNIPPHPAIIPLYDAFISPKSRELYFVFECMEGNLYQLTKSRRGRPLAAGLVASCFHQISSGLHHIHRHGYFHRDMKPENLLVTTTGLADYLTADTLAAINERRGGELKYEKDVSVIVKLADFGLARAVDSKPPYTEYVSTRWYRAPEVLLRSSNYGAPVDMWALGTILAEMLNLKPLFPGVSEIDQVYRICDTLGDPSGEYGVDERGIGVGGGPWNSGIKLAKNVGFSFPKRKPMRFRSLFSEHVPQSLVDCIAELLRYNPRYRLTSAQCIDHPYFHETLPHLQQTPPLPHIPFSSGQPLPHAIPKPNLGAAPIQPEPPRQLPPSHAHTPHTDLPRPAFANDDLRTLPPPLSTPDSTVSSAHMHQHRMFFPQHVHGSSPHASSSALVNQLRELDLPTDDLASYGHRPALSPASVAREKEKARAGSQAQAHAAHLHHYVGDLNINGGQGGTGTAPSSSSRRQSTMYDGSVFEGSVDAGGRSTQAQAQAQAQAQAQAQAQAQAQAQAQQQSYGRSSANVAAYLQQQQRYAAEHGAHLQNPSQVSLNSLTSPSNPTIGGARPEKLGVTGKKKKWGLSSVFGGDKSSANLSTVDEHDYSGTSSLKRTQSGHRPGERSEVHLAPAAASSMALGSSPLAMQSTASVINPDDPKKAKKEADRQAKELARAQRDAAALKQKERARAVMQKRNQLIEARTQTKTKGEIEFSSGTLGLEAPYTGSTANLESTANLGSTANLSQMNVPLGSMRNYAGSHASNSLASVHSHDSGHSGRSGRSGLSARALKEYEERMASGDDEARHKARRRDDDDDHSMSSFGMGLGAGSLRSRSVLTVGTVDSDPGPRRSRSRSGWEDPLIRHSSRAPSASSTSLPPFQSPTNRSHPLTSRSNVSVESQLANDFKARANMGAAASSTSSLGRLAHSHSHSYLAQVPVHGSSQASLHGPSASQRSLPLQGHGYGLEVPGGYPATVLEQGHESAPTSAYGHPKGAAVSLGAGIARHPGSSGLGRPPMSGGGTALPSISSWGEVEGEGSEPGDGQINPMFRVPPVAYEQPNQQTLPPFSDIASYASGHQQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ56</accession>
    <name>A0A1E3IQ56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029831.1">
        <property type="nucleotide sequence ID" value="XM_019178112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ56"/>
    <dbReference type="GeneID" id="30195257"/>
    <dbReference type="OrthoDB" id="2507647at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="48760" checksum="524F9C7481D76BA2" modified="2017-01-18" version="1">MPLRRNYYRAPSLDSEDDDYEPLQSIQNRQRHPARRIQPPSRANPPTAASRPSAISSSRSISHGIPSAPAQAAPGPSRPAEGGPPPQISGRPNVPEDEPVSSRDRYAVARRRLRRRVEDDEDVVYTGSSGAEDGQALAGPSRPRNRAPNHHIQRLNAALDARPRRDPDADRRQSLSNDSDLEDEIDLPPARPRIGLGGAVFRRGGARRQFVLGRPPTSPPQQHGQDAMAAPGQQFFLGGNNVGHFMMNALGAGMGFHIGLGGVGIAFGGAGPARAEADIETILRSVEVPKYPAPTAGFVANFDMEEAQSKQAIEIDDNGVVKKKRKQPILVCAKCKDPLLISEAYRTPADRIWALRCGHIIDQKCLDEIQAPRSIMEMASVDKHPDVLDEQPAKRRKGVRKAKEQEKPADEYTWKCPVEGCGKRHMSKDIGGSWVMGEGEGALQVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQR2</accession>
    <name>A0A1E3IQR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029867.1">
        <property type="nucleotide sequence ID" value="XM_019178148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQR2"/>
    <dbReference type="GeneID" id="30195293"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129962" evidence="1">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="120"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="40795" checksum="751ED05E93B5F0AF" modified="2017-01-18" version="1">MTLLTPLLVAALLSLAPSPSSAVTLQSIIDAYGLDSGSYNFTWPTETLDSSDATSWINQEWSTNGNKVDWGGNNIVFTADPSTTTSTLVRRAHHSTKTGSSSSAATSAVTYPTITDLSGEAPALRIEYPSGSYSKQTGGTQFYAQPLNASSSDASDAVGNSSRNGELERMLLAYDIWFPTGFSWVRGGKLPGLRGGNDPHGCSGGSEADGETCFSSRLMWRTSGAGEVYAYVPTSQKGFCTETDVTCNSDYGTSLSRGGYSFATGRWQTIYMLVILNEVGTANGQIELWYNGVPAVAHTDLIIRSSDSISSIGGLYFSTFFGGDNSDWASPTDQYVYFRNIQLYGGQGASNLTGSNAESGAAPSAGGSIWALGMGVVLGMVGVWMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRU6</accession>
    <name>A0A1E3IRU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029956.1">
        <property type="nucleotide sequence ID" value="XM_019177917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRU6"/>
    <dbReference type="GeneID" id="30195053"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="907" mass="100001" checksum="2F37E0CFB5527B04" modified="2017-01-18" version="1">MSSPTPHGESSQPNATSTSSLESLATRLDASVSPTSFLNDLFAPLLPPPLPSSQRPAPPALPPVDQSLQDLLTRLSMLSQDTAGEIETVMGDVGRTVPRLGYDLQFMRESASGLAVGLGMVQERVARQADWEPVEKKGKKEDESEAVKTYRALEKLTHLDKLKGRLESARDTLREAESWSTLESEITTLIGEKEYAKAGQRLAEANRSMVVFKNVPAEWEERKRLLVSLGDELERAAGEALREALRKGDEGLEQVRGFWEVFEDMDRDDEFRKWYFNEKGRGVLDLWKGAVLEEGAVEASRFTTFLPQFYSLLLQTLTSELSSIPLVFPLDQAPSTLTAFFQSTLDALHPPFSNRLSSVADHHGDAALGELVKSWEATVELGKGVQGLVDKIVFNTQGGLLSGGLETDSPSPLATTSPNALVSPNNHRRSPSHAIGMTRTNSHTKRHHSISRRFSRAPTASFDTSSPGTVDDAWETTLYEPFLDWQSSYPSLEARYLSVELETMASVWAREGRRDGKSVVGEMVKRGEGVWEKAREAGERCSAFTLGYGARGLVEAVDMSLKKVYDDQRRYLLDLAKSQAAAHSKDKGDELDFEGGLEDWASFQTGLHVLEACKRLAEKLAHVEEELGRTISEYGSNLGAKRESWGAEKVTWGAVSLLQQSTLNTAELHTLVSSPTSPLFPQSRASLITTIQSCQENLQSTILSPLLSQLSTYPTLSVWQKEPAKSKSGFDLPEFSLSPTGVISRVSEGLLDLLRVFEVYGKEEGVGWSLGTLPFTPPGSHPSGLGEAPTLEIIQTTWLSSLSLSLLSHFTSTILPGISTLSTPGQAQLKEDLGYLENAVRALDVEWEELGIWEKGVGLDEAGWRGAMKEVRDGKEKEKEKEKERREAGKAEEILRRIGRMRGWRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS13</accession>
    <name>A0A1E3IS13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030039.1">
        <property type="nucleotide sequence ID" value="XM_019178000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS13"/>
    <dbReference type="GeneID" id="30195139"/>
    <dbReference type="OrthoDB" id="2565142at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN91413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="406" mass="44205" checksum="CD77D6D9526FB6E8" modified="2017-01-18" version="1">MVQPVPWGDWDIVLPGAVSGIATGMAYYWEYLMKAILGSIGFGELGPIAGTSLSPLAPPSFTVASPPSTKSYIRQIAARGIFATLQSAAMGGYGEAIIGTMIRLSFGSMAVVSGGLVIIPLAVDLLEYYEGVDNVKDLAVLVFHQAEDGWRWIKVHIGEALRKRHLETGKALQGRFVDTRATIDFALKEAIRLRDDVDHATSDLWGGAAEDARRIIELANDLENQDQASLIRLGKAFGDKLREELRREQAEWAMIREGIQGLVEVVKDGWKGVLGWWTNWRTPELVHIWSIDSRSLQNSTESTSSLSTGAEADSFAQSPSTLPADITPAELLLAPHDPTSLNSQPSPLLGHHFSPSTEALHLSLVGVFVVLFFAGGLSAYLRKLRSSKKEKKALRVRKASYGSIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU26</accession>
    <name>A0A1E3IU26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose transporter</fullName>
            <shortName evidence="9">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030247.1">
        <property type="nucleotide sequence ID" value="XM_019177863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU26"/>
    <dbReference type="GeneID" id="30194997"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN92113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="45921" checksum="CC6B4007C5E5AB6A" modified="2017-01-18" version="1">MAPYTPASSRPHTPLGLSPRGSYTNLASAAYEASTPSGLVSPGGNALGAINDEKDRMRAEREVQEALQKAQDEEEKAKKQEAPAPAGSPVLPILAYCMASIMMTVVNKFVVSGRQFNMTFLLLAIQSFVCVACVWVAKRIGMITFRDWDITDAKAWFPVSSLLVAVIYTGSKSLQFLSIPVYTIFKNLTIILIAYGEVLWFGGNVTPLTLVSFFLMVGSSVIAAWSDISSTLARISAGMAVVDPTSGADVPLIAQAGLGGFNVGYAWMAINCAASAAYVLFMRKRIKVTGFKDWDSMFYNNLLSIPVLFIASLVVEDWSAASFSRNFPIEGRTFLLSAIAFSGAAAVFISYSTAWCVRITGSTTYSMVGALNKLPVAASGILFFGDPASFGNCAAIAVGGVAGLVYAVAKINQGKEKEREKNGRKGDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVS1</accession>
    <name>A0A1E3IVS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030340.1">
        <property type="nucleotide sequence ID" value="XM_019177589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVS1"/>
    <dbReference type="GeneID" id="30194720"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="120"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN92713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="227" mass="24305" checksum="C00C1FA130994BBA" modified="2017-01-18" version="1">MAFPAFRTTFASTSRVTLHHLPPLTHFARSGSSLAHHVTSPSPQSYSPTSSPAYHGSVGQQGQLQHSGMMSGGNGKGGVKEMHVAPTPTPPAAPAPKVQPKASERPPRRTGNLRGKKAPITMTPAAIEHLRALVSSPTEPRLLRIGVKTRGCAGMAYHLDYVPPPGGKFDEVVEQDGVRVLIDSKALFSIIGSRMDWRDTRLSAGFVFDNPNVVDTCGCGESFNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW73</accession>
    <name>A0A1E3IW73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030439.1">
        <property type="nucleotide sequence ID" value="XM_019177688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW73"/>
    <dbReference type="GeneID" id="30194821"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="588" mass="63715" checksum="6D60248BB7B78C16" modified="2017-01-18" version="1">MPGDHSTSPTLIDEIRGGLSGEGTPFAAEAPLSRTSSKKLSHHDTQSSSTEKAAELPKHEDAAPQADESGLLSGARLYLVFLAMMLCVFLLLILFTDQSIVSTAIPVIVSDFNAFDQVSWIITGYFLTQCGLILLVGQMLTVIKSKWMLLGSVFFFELGSLICGVAKDMTTLIGGRAVQGIGASGMFVSILTIIAIITRVEQRAAFMSSFGIVFVISSVVGPLLGGVFTERVTWRWCFYINLPFGGLAAAAVVFLLPAHAPAKSGSDDTTERSVLHKILRLDWLGTALIFCCMTCLLLALSWGGNEYSWKSWRIILLFILGGLLVIAFGAWQWFYDKRALIPVSLFKNRTLTMSSGAIFFWMLSMLGGTYQLPLFYQAVRDHSPEKSGIDIIPFMLAICISIFISGGFTTKFGRYWPFLVAGPPFAASGFGLLYTIDSSTSSSKIIGYQILAGFGIGLSFQMVFMAINAEYHERPALLPQATGTISFFQLTGAALGTGIINTVQSVYLNTEIKRLAPDVDFNLVRQSVSAIYTLDPAQRPPVIDAYVISITKSFIPIITSVCLALVFGGFIKNHNMLTKGGAGGAHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWP5</accession>
    <name>A0A1E3IWP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030255.1">
        <property type="nucleotide sequence ID" value="XM_019177871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWP5"/>
    <dbReference type="GeneID" id="30195005"/>
    <dbReference type="OrthoDB" id="10320337at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="391" mass="43916" checksum="668FC56F22F19056" modified="2017-01-18" version="1">MQGGHPYSQGGYPPYSTASGTHPYFSPTADSYYATRPGSFSTNGPSAVPGYTTPHYGSGQGRRPSGVWMGSMPYGSPPIRPNTYATRSRDAFSGEEDEPEYERSRPDMPDWELKPEYESPEEESDADSDYDGPPRAPIPPTLRRSKKKSLGSEYIVEEMDNEGETVRMDYPAPRRSGRRKTTADGWRRQSNGAAATSSRSEPAATSAPAPSLPRWTMRNFTKNHEHSSSDRMVIIIQDRTCYRLWESQLPEARQKGEGERMHPDKIAIARAESWLSERSGTSLSGGRYIPAKFYAADTGRDTDTVFAVPSPYITSRGEEEKKAWVQSCCSSLWPCLRPEFDQQDGRRSMLKKMKEGSRTFFGSQFKHYAKQDLGQEEESDDEDEVVMQGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXS9</accession>
    <name>A0A1E3IXS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030504.1">
        <property type="nucleotide sequence ID" value="XM_019177351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXS9"/>
    <dbReference type="GeneID" id="30194474"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20175" checksum="9D6AEC6B9A351A2B" modified="2017-01-18" version="1">MYSTVQRLNHLSSLATTYLLALLALVSLASFLAQPPVSVGSVHVKDLILTKGRLNRLGARPEELASLRFDIRTDLNPLLNSYNTKQLFVYLTATYEEESSSAVHDVVLWDRIITRKKGRGNVRVEDGKNKYQWHNPSHTFKDIPTANFTLHYSLMPYVGVLSSGVAAVAEGPVAIPELIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXV7</accession>
    <name>A0A1E3IXV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030578.1">
        <property type="nucleotide sequence ID" value="XM_019177425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXV7"/>
    <dbReference type="GeneID" id="30194551"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17835" checksum="2D9AC2A0BEF79E2C" modified="2017-01-18" version="1">MSCIALRALPRTRHLISPSMRIARACASSSAALPTPPTSNPSPISMSPVQSDAIPKITPTPLSRDVLVKLHKLSALHPPPEGSAEEAEMMEELGELVGLMDLVKQVHLPQEEIEGLLGEGIGAIKIGQSEASGKEEETLEKEESGKKLLAYSPTRVGDFYSSALKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYM2</accession>
    <name>A0A1E3IYM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030630.1">
        <property type="nucleotide sequence ID" value="XM_019177477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYM2"/>
    <dbReference type="GeneID" id="30194603"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="444" mass="47760" checksum="F9DCBD1A4F4F6DFE" modified="2017-01-18" version="1">MPSAAPSPFHTLRTHSSPLATLHFSTSPSNGLLYSGDQEGWISVLDLRVRRVVAFWKAHEGGVLGLGEWGGGVVSHGRDNIILFHEPLKRPYIAIPTSTNPDPTAHGPKIANALPTNALNFCRFSLTQLSRNGTEGSKGKGKESEGLMAVPSLIDSELVDIYHVPSLKRLHASINLHSQPAPPPSGVDLPGTSKSGLVMSLNLFFPDPSAISTEDHVGLMITYESGHTAILSTPASSLSEVYDARMSKRPNPWDCRWMGKGHNEAIMAGTCDSRGRRGWTVSADHRLVRYEFDQVWDGKLRKDDEDVMKPYATKQIGNSSIAVSGDDRVVAVGGWDGKIRLFSAATSKPLGTLSSHRDSVYALAFAHRPSSSPAPLLSEQDNLTQTAESTIVPLSDDTSDKDDGDSDEDMDGVPPKERWMASGGKDGKVALWGLMDFGKGSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYQ2</accession>
    <name>A0A1E3IYQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTPase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030660.1">
        <property type="nucleotide sequence ID" value="XM_019177507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYQ2"/>
    <dbReference type="GeneID" id="30194633"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="128733" checksum="6772AD43E68B0B3D" modified="2017-01-18" version="1">MSPVPPPPGAFVPSDDWTDDPSFDLSPNASQLALPASPSPSSSSSHRSSISRSHTSSPLRQSFSSAGKSSGLKLRQHQKQEMDALDDDFDLPEGDLPPLSPRPTPKTQSRPRSSTSSSSSSLITRTIVGNGPQGVGTITKMGFTSPPTSSGVMAGTVKARARALEKAWEADVDLDELDQAVDKAESVGGTLRTKPSFHGRPLPPKDLPGEDALDGFGDLDDATFKPSKLQLPPKPSPSPSPSSSKMGTVKLDKAAGWERFGSGSSKGGSLRMKPSFDGRPLAPIQREQAGADALDDFADFDDDEATFKPPISGLPTKKATSSKMKTISLESVSRGGTLRMQPSLEGRPLAPPKQKQPGADALDDFDDLDDDTFKPPKSQLPPKPSNPRMGSIPFDQGWENFGQVAGRRLLSPPRKTRPGAEALDDFLDLEDEDQATLKAGATIKALLPPPKGKKHSVSSIPDAPAEDPELEADFALPLNLTNLALASQPAAKPRRKGPRDSAASTVISEWDSPSASSAASGRKQGWGWGSEDSPSGKRKSETSATSVSDDLEKDETKKEGDMLDEEEDLESGLVFEPAFFSNDRAKDLNSILDRKRRPQFAPQPQTPPGARRGGDDSFEDGLMLDEPGVELSRHRLRAQKRARDKLPAPSSTLRKGIQPQPQKTVVKEREKAWEKQREAAWGRNTPVQRERTQSSLGMSLRSHSISTVARETPRGAEPAVTGREKEAMRSRSGHLHSMLPPPPPVPSSQPPTPSSSRLRHQKSHYQIGAPPQSPSLTRKQSLSSLQDAIAERNYGTQHFDALPPLPVPTNRYHNSTSRLTMPTSSSRAKIRPPVTSIFPTSSPSSASTTMSDQRDRDREIRSRMYSTPIPRMVDVPKKSRDYGDGTELDGIDDLRVEEDAREAQRSMVGLGLGKPSRLDHEPRTTSHGKEKSEKEERRKKSGGTTTTGLATKKIRRRGLIKHLGGTDKRKVVGEMIWNPNTLRWEGNEAVLRDFDTISSSRPALITHYTGSSVGVGGLSSPVASVAAAAPRIVKDMQFDPIQMKWVSVHPEDDEPDPFEGMADDEDEETGRGTIRAGAGRKYVPIGGSSMGPGSMAATSSTWSHRMASESSMAASTASWEDRASHHVGVAISSELWSECKEAEERHRKEMKGWGLRAPSGSSELRERERREEKRLWEIRHLAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J093</accession>
    <name>A0A1E3J093_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030834.1">
        <property type="nucleotide sequence ID" value="XM_019177253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J093"/>
    <dbReference type="GeneID" id="30194372"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="801" mass="89792" checksum="D0FB32F0AB07333E" modified="2017-01-18" version="1">MIRKQRPTFTNAELEMQLQQVCPPLRLSHAHPPQINLDPTSTTENLEALAPLIKSIQDTDSEQLYLKSLDAFVDEKEKEIEAICAGNYEDFVSSVSNLLTIRQGTGHLRRRIGELDGQMGDVGRALGEKATQKRALLEQKKVARNMDDAIETLQACLRLLDLVHRVSDMVREGKYWGALRSLEDLLHLPPASISQTPFYAHVMSSLPSLRLSIKDAVTASTKSWLFDVRESSAKVGKVALDQMSVRIKKWRARREKEGGDRLARVGGSLELVHNERVEFDALDNDEINVDFRPLYQCIHIYEALGAKTELQRTFQDDRKTQAALILSSRMATTPATLVTTLPLLLQELVGFFVIESHVLDTMPEFRTQRDVDELWDEMCKNIVDVMGQGLKGCSDPEVFLSTKSEVLLFVQTLDVYGYNISELNGLLIALFERYSELLLNKFSSDFEQASIVTDDDNQPMMVNDQEEFDQVAGVCWLATGEAESLAMQGFPQAMPFSQTYPMCCINTRNFVDQFYQFTDGVAQQHLDIDEVLRKSLDGLLSTHVSKQIAKRLLSMANLSQIAQIVINLEHFLTACDELESVLMNLRASQRGGPIKLSAGASFTSTLAIAQSRIDSVVNSKLESFFELAEYDWTPARPQSTVEEPSTYVFEMITFLTAYVDSVLIGLSEEVKTRAYSNALGRINKWLMDTLTGSSVPRLNESALASVLADVTFIETEIKRLEKRELDRVFDETINIILSDAVQAYMEPSVRSVSYPSVKPLRLAMILAKLGKAAAAQGGQANLFKAERRRGEADEVARLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0L5</accession>
    <name>A0A1E3J0L5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030905.1">
        <property type="nucleotide sequence ID" value="XM_019177324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0L5"/>
    <dbReference type="GeneID" id="30194446"/>
    <dbReference type="OrthoDB" id="2577873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="560" mass="58354" checksum="4811A6B5023EC270" modified="2017-01-18" version="1">MSDNCGFVRLIPVSQALADSLFLSSALPGFPSPSPNTYTTTNNTTNNTTNNTTSSDGNAPEVQLYDSSGIFPVSYNLSTVPCAVIGRDLNALGIQLSGHSCALPASYTPSTINYTSSTNDDGNALGPQLSPVTPSPASSGDKAKPKARSSVHATNTRSIKASGKEKKKHAEGYKRKSMSCEHCKQRRKECDGTDFNACTRCTCDGIECKYVLAKGKRGSQKALKKLAAMGRAPSADGVYIATPSTSSLASSSGTSSMSPITPITPMTPARSAVELSSGPSPASVSAGLTSGFATPHIFMPFVPPAQLPVAVGANGMLKDHPVVEMQQALFDNEFDSCCSVLAAAPASKAAARYHPPTPRTTPVKPTYVRPVDVSPVQAPTFSLNNTSVSSTLPPVVASQPQLPAVTGQGLSESERLAFDELVMDFDLDDDIVSVPAEVPCSAATIASLPTSDTTTLKPTVEMSAVSDSADHTSINFSYAGFLAPDNTPWYSAPQAQVGNEAAFVGNENVGWGVCGTEEMETSNAGSWGAIESPFNTTPFGDSFTPVADEAADCGMRGLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0V1</accession>
    <name>A0A1E3J0V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030676.1">
        <property type="nucleotide sequence ID" value="XM_019177523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0V1"/>
    <dbReference type="GeneID" id="30194651"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF1">
        <property type="entry name" value="DUF659 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN93571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="501" mass="54088" checksum="4DBA9219AD3C2157" modified="2017-01-18" version="1">MDDAYGSYYSYYSRPRDAQPIVRPDPITDYNIQYVEGSGSSRGKSIDLVFILDCTGSMQKYINSVRDHIIGICDMIRGEEGLNGPDDLRVAVVNYRDHPPQDSTYIYKFHPFTSDIPELQTYIKGLTASGGGDGPEAVTSAMAATLTELEWRREAARMAVLVADAPPHGIGEGGDQFKGGDPLGHDPLVVARTMAQNGITMASIFMVACEDTLSGYSHAVDFFQAICNMTSGVMLPLFSADLLAMTIVGSVLENMDMERLITEIGMEVAQRIKEKGESMESVEEVAQELHERLLLRNEQTKQVRLPEVYVPHENAKKNVSTWMNASCLGDAVPHILAVPGKRLTEKFRKQNYAAGFNYTPGGRLPPRRSTSASISSPPSTTTTSALGIPPTPSSPTAHSPPTATSPSRRVVSDFKPFGAPAAGDGKGVSVFGAPMLSTPGPGGGMFGSMGRAPASNGGLRERQEEEDDDDDDEGARLRREAISLDQARRIATQAVFRAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1H2</accession>
    <name>A0A1E3J1H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030978.1">
        <property type="nucleotide sequence ID" value="XM_019176946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1H2"/>
    <dbReference type="GeneID" id="30194053"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="311" mass="34224" checksum="D13C9CA56FB78750" modified="2017-01-18" version="1">MSQPGFLSAARYGKDLVKVARVVRDGEQHHVVEYVIRVLLEGEIETSYTEADNKCVVATDTMKNTCHIFAKTSPYVLDAPIFALHLALHFVTKYAHIHKAFIDIIDLKWSRIAVDGKPHKWSFVRDGDEKAIVECAVDASKGVESATADLKVGVKDLLVLKTSGSAFEDFYRDENTTLPEVADRLFSTSVALQSLITLPPNIPLTIDNLAEIQKELNFKDLKAKVTTDVLETFATDESASVQATLYTTLQRILTSCPAIKEVSMQLPNKHYIPINLSPFGLENGLTKEGGADVFYPAPDPSGLITATVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1I2</accession>
    <name>A0A1E3J1I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030988.1">
        <property type="nucleotide sequence ID" value="XM_019176956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1I2"/>
    <dbReference type="GeneID" id="30194063"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="205" mass="23819" checksum="671E2F0C68EA968C" modified="2017-01-18" version="1">MSEPLSRIAVDHESDWIRVQKNVAQAITDSMEARLATMPGGKDGEAARVMRIELEERLGKIQERMWHMAKYNIQVNGQNYEDYVQATEGFDEVLDRKIWGLNTERVEHETRIAERRKRMPDAINQMEEDLEGRREEAEWLPDEQEEETDASNAQEIPKPERYEEVRETFEIAAANLAEVARSAPIQLQRAQRAQTVQEEITNMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Q0</accession>
    <name>A0A1E3J1Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_04923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031058.1">
        <property type="nucleotide sequence ID" value="XM_019177026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Q0"/>
    <dbReference type="GeneID" id="30194136"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01226">
        <property type="entry name" value="PH_RalBD_exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="13">
        <location>
            <begin position="459"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="701"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN94779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="812" mass="90546" checksum="25BD5D7E532721D5" modified="2017-01-18" version="1">MASLRRPSAAPPRGSNTGPIQSGPRPPLPNGNQKQKRKSKVGDKIKKRLSMRYTDNQSFSIAPPMPSQPDYLDNDPYGGMEELPPDDGAGGTMFNEYGSPEFNESAFTQPLRVTDRSSDRQEHLADEGIRRRGATDATANEEWDLTQLGDEKLDLQAYVKKVLTGADEEEKKRLKAALLRERQSNKKELQRSVFKHYAEFVTISKEISTLENDMLELKELLGQWKDLPQLMGMEDTLAPTLDKNVERKRTQRNSVLDLQNLYRTQLTQLWSIVEGSQKYLPVVPGRHLVFESHNVIELNAATYKPKQSCSMFLLSDVLLIAGKRRMKGGGSAEVGTQDKEKERGRLVAERCWNLSELVIVDVKDGGDLVNVIKVQRGKEYCVYKTNKSDEKRAILSAFKQISRELNEKKRKDNEKEQERRKTMWLGGNDKGGDSLSVMGTPGRALSTIGLSMTNSKDLRWIDEFGDDLTMAIATRDWEKALALVEKGQALAKTIESDPSAHALITTRLDQLVPTFVSSLCHDLSSPSLRKTASARLISLLIQLDRSELARDTFLKARREIMMRRVRSIKCEGDISSYINELAVVCFTIVRHTSDWYMNAFKESRMASGFVTWAKEQIETFVDLFRRQVDVPDVDQSVVDECLHVTASQNRKLLRDVGLDFTFLLTSLLQPSAGAQTYFAITSPHPSSTPVSGRSRDQTFSAYSALSDSTSRPSIARDRSNSGYTTSPTKIRERSTSGASRVARERSGSSVQQSVPPLNLGRSLPPAGSGANGNGMGMDNGRQTPSAQGSPSLPPRSERRAKAVPKTNMEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V8</accession>
    <name>A0A1E3J2V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031164.1">
        <property type="nucleotide sequence ID" value="XM_019176689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V8"/>
    <dbReference type="GeneID" id="30193784"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46262" checksum="6C2FC984CD4F453A" modified="2017-01-18" version="1">MTEPRPYRAGLGLPPVFTIRSGEAPSRDAHDNIVEHDFDAEEDQDQAEGSHPGKKVESKEPIVFEALPKHLAWPEWNVNPYKHGPERLKRPPTFVKSTITYDELGRSVSDGVEVDIDTGRSEAVEAAKEKREVDSGDKVKDWYLSLAKGSGSNAASVPAAASRPVSLTPTYIPPDPPKDPLHMPVKRQDWFVRRPLVTSQSLPSSRPSTPAPSSISSLLSLPSIPNAKASNKGKDKAHYYALGPENKGYGMLQGLGWGGGGLGKPEGWTEVPDDGTPPSQECSIRKDDKGRRKRAHSRPEDEVQETDPKGNPIIDLTLSPSLSPSPSPSVSPEPSPMSGPGRVTPISTALKLDRLGLGHSHTSQAKITHTQKEIVKAQKKAKMGHKRVFKGEEAGMSKKEKVDWKRKNKKDREDRIRLMAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3P5</accession>
    <name>A0A1E3J3P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase GliT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031265.1">
        <property type="nucleotide sequence ID" value="XM_019176790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3P5"/>
    <dbReference type="GeneID" id="30193889"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="37223" checksum="81D89006142F16B6" modified="2017-01-18" version="1">MTSRTQVDLLVIGAGPAGLAAGQMFSRLKRSCLIYDSGVYRNDVSDHAHAVAGFEGVNPAEFRRKYRQDLIEFYGDTTTFKQGKITTLNKVGEVFEAKDENGNEVAARKVILATGLKDKLPDIPGIADQWGKRAIHCIFCHGTETANKPFAFLFTAPNAWINTGLAGTMLKLWPSLKHDPVYVLTHGLDVNTAEGRKAAGLEPYWDIVQKKGYTIISSPITSVKSDADNTTLTITFQEHSSIQVPYMLLFPEKCTPNDHALPFVNEQLFGLPLGPMGTIPFDPASQKSGGGGGMPRMGDSPKTPVKGLFWAGNSGAPAGNVAISVAQGQMAGAVAGDELGDEDLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3R6</accession>
    <name>A0A1E3J3R6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031285.1">
        <property type="nucleotide sequence ID" value="XM_019176810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3R6"/>
    <dbReference type="GeneID" id="30193913"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="234"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="42478" checksum="E20BF0574400C955" modified="2017-01-18" version="1">MFPITHPEPVKEYIETAHDVERLLRELKPDLVIVDTMFGPARDAISKMADVRFITLSPNTIKELAVGDQGLGAFLWPAHTTGFPFPVPWYLVPLNIIALLFPLLYFTFSSYHKAFDKARHAYGYQKRVPLFEIAQVRPSKTLCMSTPGAEIPAIIPESLLCCGPILQASTPLELADKELYDWVTARPTVMVILGSHFLTREPVANNMIAAFRVLLDKRRDIQILWKLRKYGEYELQGLEEVGDRLRVVDWLEADPLAVLETGNVICSVNHGGSNSYHEALFTGTPQVLLPAWFDCFDFGSRLAFLGNGVWGNMSSGLAVSQPEFTKALLRVIGATPDAPEAAKILARAKELQDIVTDKGTRLGRDVAAAHILHELEYGPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3S7</accession>
    <name>A0A1E3J3S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031295.1">
        <property type="nucleotide sequence ID" value="XM_019176820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3S7"/>
    <dbReference type="GeneID" id="30193924"/>
    <dbReference type="OrthoDB" id="2576155at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="284" mass="29246" checksum="12F27E73EDF35CB7" modified="2017-01-18" version="1">MDVDKSLDDIIATKKQDNRPKQAQRPPIPRHSTGSNGGSRPTPYARPPPRSTGDRWVHDAYPGRGGFNGRQGRAAPNPLIAGTGATFTKENQRIEIVGLHYEVSNQDLKTIFSQAGTIADGPQIRYDRSGRSTGAAWIEYTTVAAAKNAINKFDGAMTKGQTISIRYGRPPPIQNPGPANGAGPGPARNGSTASLLSRIQPSAPAGGKAPKGPKGAANAPSVREANGNGAAGAAGGGRRGRGGRGGRGGGARGERPGPKSAGDLDSELDNFMKPADSAGDVEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4A8</accession>
    <name>A0A1E3J4A8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031363.1">
        <property type="nucleotide sequence ID" value="XM_019176435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4A8"/>
    <dbReference type="GeneID" id="30193529"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130118" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="147"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="276" mass="29718" checksum="4279F19BCE49A353" modified="2017-01-18" version="1">MLSVVKFLVATHGIALGWGKAIDLGANDQQHSPEARWITQSYRVGESFTYDSDMLAITKISEASNVSPIIVTSTLYISVYHGTTDESAHPTATSMYDDEGVVAVAISTSSGATSLIDVSFTDSHVTPPSTASTKTHSSASSTSSATADSQTWVDAHNRPRSQYGAANLVWDDQLAVVAQQHANLCNKEHTKAAENLQWGSAAYNWNKPGYSEATGHFTQVVWKDTKRVGCYIAQCPQGSVVDEKYTTSFQTACEYDPAGNYVNEGEFAQNVGKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4H4</accession>
    <name>A0A1E3J4H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031140.1">
        <property type="nucleotide sequence ID" value="XM_019177108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4H4"/>
    <dbReference type="GeneID" id="30194222"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="208"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="62231" checksum="B1726B10A934432D" modified="2017-01-18" version="1">MLRPWTTASEKTWGDMTPEAIQALCLSSAPRNPIYRHPLFRRIYLLFFVLSTLVCLLPIWALIYLPKGNRPRDGWSLQRCLRARWGRRLCGLVARCEIDYLGRDLALDMDTTSLRHSHPVTIPPAPDDLVRGHIKETLQQLHDSRGAWDPHFVYRKARKAAGAWGAWNLDDGHHRDFGFEPVKGFWFTGEKTSPVQPPTPRLEDDPVMLHFHGGGYLCGTAAETDLTSSICKSLVKYSPIHHILSVDYRLAPKGPWPLPLMDAISAYRWLVRDRGIGEADIVLGGDSAGGHLALALARWLRDEGAAVGLNMPRGLVLFSPWSDLGFTNAWGKDEYRFNADSDVIDDTFGPFACSLLMRAQPISLCYASPYVSPASSTIPTEDLFTNFPPTYIAYGSAERLARSIQTLFRRLQSGRVIGKQVVQDKIFVGPDAVHDFAIFPWMEAETAMMYEDLDGWLRELLSTEVDIEDEATEEADAVSPQVFASVFNSPMDDSASYRRLSRHRTNESLKSCKSPVMGATPDSGMMRIVEDMKGEGMSMIDIPKLDLDAPASRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4X6</accession>
    <name>A0A1E3J4X6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031569.1">
        <property type="nucleotide sequence ID" value="XM_019176641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4X6"/>
    <dbReference type="GeneID" id="30193736"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF2">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="160"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="456" mass="50589" checksum="672398CA3636E6A2" modified="2017-01-18" version="1">MASEATKGKLTGRVGIVGTGHRARLYTQAVADRPNVTVVALCDTNEARMDWHNKILLEAGEPEANKYPAEQFVKMLKEEKLDILVVTTIDYTHDAYIIPAIEAGIKVLTEKPMTTTVEKSKRILASTKLPNAGSLTVLFNYRYNPVHWKVAETLSKPPSEGGIGEIKSVHFEWLLDSVHGADYFRRWHRYKDMSGGLMVHKASHHFDLVNFWIQSTPASVFGLGSLGFYGKENGQKSGWARTYDRALDAKEAEDDPFAIHLEDEEGLKGLYVDAEHLDGYHRDMNVFADDITIEDDMSVLVHYDSGVNMTYHLTAYSPWEGYRVMFNGTHGRLELEVIENAFRLPIPKGSNASEHVHGTAALPNEGHSKITLHPLWQQARDVPFEVGEGGHGGGDEAMLDEAFGPRKGQKERRCPVNGLGADERDGALAMAVGLAANESFKTGKQVFIKDMLGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5J6</accession>
    <name>A0A1E3J5J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031580.1">
        <property type="nucleotide sequence ID" value="XM_019176652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5J6"/>
    <dbReference type="GeneID" id="30193747"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="814" mass="89521" checksum="00F15C49B854CA03" modified="2017-01-18" version="1">MSVIAHVDHGKSTLTDSLISKAGIIANAKAGEMRFTDTRQDEIDRGITIKSTAITMYFPLDPEDVKDIKQKTDGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQSLTERVKPVLIINKVDRALLELQVSKEDLYQSFCRTIESVNVIISTYTDEALGDSQVYPEQGTVAFGSGLHGWAFSLRQFAGRYAKKFGVDKSKLMPKLWGDNFFNAKTKKWSKSADNGGERAFNMFVLDPIFRLFDAIMNFKKEEIPTLLEKLEIKLNNEEKELEGKQLLKVVMKKFLPAGDSLLEMIVINLPSPVTAQRYRVETLYEGPMDDESAIGIRDCDPKGPLMVYVSKMVPTSDKGRFYAFGRVFSGTVSSGPKVRIQGPNFVPGKKEDSVIKSIQRTVLMMGRSTEAIEDCPAGNIIGLVGVDQFLLKSGTLTTSETAHNMKVMKFSVSPVVQVAVECKNAADLPKLVEGLKRLSKSDPCVKVMMGDSGEIIVAGAGELHLEICINDLENDHAGIPLRKSDPVVGYRETVTAESSMIALSKSQNKHNRLYVKAEPLGEELTKDIEEGKVAPRDDPKTRARYLADTYGWDVTDARKIWCFGPDTTGPNVFADGSKAVQYMNEIKDSCVAAFQWATKEGGIAEEPMRGIRYNILDCTLHADAIHRGGGQIIPTARRVCYAAQLLASPAFQEPMFLVEIAVPESAQGGVYSCLNVRRGHVFSAEQRPGTPMYTLKAYLPVSESFGFNADLRAATGGQAFPQAVSLQLSADPTEVGSKTNLLAVQIRTRKGLKPDVPPLDYYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6R5</accession>
    <name>A0A1E3J6R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031611.1">
        <property type="nucleotide sequence ID" value="XM_019176201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6R5"/>
    <dbReference type="GeneID" id="30193292"/>
    <dbReference type="OrthoDB" id="2574658at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="58317" checksum="DD0F73AA115BCA61" modified="2017-01-18" version="1">MPNSKPPADPFATILLRTSSARRPNPSKLSEPIPLTPLQGSRLSEDSSSGPSSLRGKPRSRPTTPKSDDMGETRSLSRPSSKRGKEVDAGTTKDSWGRQRAEQAGGNPERMKEDAAMEKWRKWVIEQPLQSGVPSTSPLKGKGSPVNGGQKIPSVSLNNTHRLSVTNSLLRTPSAFDTRGQSDPETSITSSLRTTSPRASSALASPFYPSGFGSPGGGGEIYNTDSVLALRDVELAVGDDAWSNAERAKAAPRRMSNKPRLSQIPNPFGDVATRLGSRRVRPIVLELIQALGHFLDVVWSTTYPERSCPWIIDNTEECPVTPSVRKTKRARHTDSDPTITSELEWKSPMITAVQEGKRTGHVPTRPTSKDLGFWRDEVEFGIRDVDEVVGVKKGLGRAFGTALKEGRYGPPDAGNALGQNGEGAGDFDPYALLDESELMAGGASGMGGAHPKAGSALLVDLLGASSSSSGTPTTSGPSFDSLPDFNVNLASPVEDSIKAKEVKSKQRIEVLIPGIESIEGAEGMTLEELGRRRHREWLASRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6S1</accession>
    <name>A0A1E3J6S1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031788.1">
        <property type="nucleotide sequence ID" value="XM_019176378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6S1"/>
    <dbReference type="GeneID" id="30193470"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="604"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="668" mass="70382" checksum="E02238495A8B6E45" modified="2017-01-18" version="1">MSISFNDPDILPAYNAVKDATADYDWALFNQSGNDLRLQATGSGLEDLEEEFMDGRIQYAFARVKDPSSKLDKFVLVSWCGEGVPEFRKGLYFTHAAQVQDKFLRGAHLVIQARSDIDVTPAYITKRIQESSGSKYISHASTPTTAPAPKAAPSYRPSQGLGGSQGKPAAVPAPASTFARPTPAPPARVPAAPAPPFRQPSPPPVIKQEAKPTATAVMSANTPAEPEPAKPTQDDRIAPVGTAYTPIKLQPGKLADRWNPAASQPDEEEAPVKGPSIKDRMSAFSGAGTAAPSAPQPSGKKLTWSERQAEAKKQREEEDKASAAAGAAATSRGGISSAVTGAPAVAAPPPPARAVPDSAEKKEDDDDWDAPKVSAPVPPPATRAVPPRPVSPDSDEEKEDEDDWDAPAPPPPAVPFRPSPVVEDEPSAPSAPAPPPPPPPPPPPPPAPVADPQIEELSRLKQDLTLGEAPPAGPPPIPVDSRPKVAEETAVAGKTAKVLYDYEAAEDNEIDLREDEIITQIEELDEGWWSGVNPAGKAGLFPANYCELVEPTEAPAVESSAPAVESREAPAVETTESFAAPPPPPPPPPPPPPPPPPAAAAPAAQKEYMVAAYDYEAGEDNEISFAEGDHITDINKIDPDWWQGTCNGKEGLFPAAYVVGPDEYPLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J708</accession>
    <name>A0A1E3J708_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031711.1">
        <property type="nucleotide sequence ID" value="XM_019176301.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193392"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="122"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="10">
        <location>
            <begin position="911"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1272"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1351"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN96465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1362" mass="149139" checksum="B2E1D1EAEDED9703" modified="2017-01-18" version="1">MDLYHASDGGLFRTPTPLQDYPNIDALYQHVAAATAIPDHHILLFLEDGRELQGSVLHQLQNEPVTRAERLPLKVYLYNRDTFWSDPEAWAAQFQEELQLPPHIDLSSLQGIQHPFLIAHDHLSHLQSLFDAQSSALYIAYTNLSQHLQPVVNEFQSFASRVETSFKSEEELIKSSKLDMALLPKLAINPVMLKKREGEEWKERTMGDYVNGKKMEQVRESCRVLHVESVERFNSIADNLDELVEQSERESEAYDTRAAQVRNEFSDGLARLEVALGQLAQLIDSGASDVEEGNTDFVELDQAMREDLTALTSLKNEFTLDVHVHLRQVASLQSQTHDMLSPIRKLDADLSTQKEKSAFPHLQRLHQIPFAYATAVAEMIKRRDFGQMLGDWTKRLKGTLETFVQVEHKRRQMVQGEWLSQLPFSIPGLGENQPPRVDITVITGSEGISNVTLGYEEIEKLVAWLESIQDDPDVRAVMQEGDEERLKDMQIGIESLVSRLDTAGMELDRAVERGVLHPKSLPQSRSTSTSRTTLHLSSQLRATTKERDDTIQLLDTQNSLVESLQTRQAELQDELVRLRSDLEEEGLARQALSQELEEREKEKEDRSKEDEDLIKGLQAEMAQEKDRATDLGVRLQEALLDVDGLRNGERTLQAQLHELQEERSNALQDQQAAQAVIANLESEVAGLRAELGTTVNQLEQAREYRETALKHQMAEAERLLRDQIAEADGDRAVLDQQTLTLTKELEDLKVDTQRQMSAAENNSIRQIDGLKAELSLTKAQLKDNQQRELALKDELAVAKDSLTASVQDKSKLGDQTREAVALAGRYYEACQRLFDAINSSTTISGTAAQGRSRSPTFHQSGSLPAAKSHFETSYETKTVPGSDQLEASSTSAASFATSPASSFDIQAFADAVTKTIGMAKKWSKSCRQYRDQAKNKISFTNFSKGDLALFLPTRNTATKSWAAFNISAPHNFLKLNAALLEQIRTREWIIARIIKIEEAVATGGESLNTNPFGLADGLRYYTHTVEEYNPHAARPSRRTPSASFGGSQIMTSPQRMLSEGASTVGLGVMTPLKVQSGITAGMPGVGRGRTQSGYFPPMKSLDEQALGSGSEELGEKEAADKAGLSFSTSSLRGSTSPSPAKRGSPLPFGRPLSPLADGSLSPKAGPITVPASATRFTTSAHSPAQSNFPSRASRTSLTTFITARATSPPSQAESQQHLSGLNLGNDRVSGRPASVTSTASSYPKGLGIGIPGGKTAPSMAVTTSHEGEDAASSRSPGRSKSPSVLPEASTSPGHKSRRNRPSSAQSKRASFSLLGTAPDIGTGPSGGPVGAESGNGKPSDGRKGSVSAIEMLRRIDKGSGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8V3</accession>
    <name>A0A1E3J8V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031597.1">
        <property type="nucleotide sequence ID" value="XM_019176187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8V3"/>
    <dbReference type="GeneID" id="30193278"/>
    <dbReference type="OrthoDB" id="5540949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="242"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN96351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="489" mass="56865" checksum="A5BF569BCE2A2B21" modified="2017-01-18" version="1">MSDIGQRRAEAETIVNILLVVATLQQTLDLPDDFDSCDPDFTEYFLQLIILLRASGLPNWQSHIGWLGLFSPKMTLLAMDTFSDYLQYLQQTRSVARPLTYNRCQRLGENVWFVIFDHQSDKDFKRNARMFKKTFHSLWEAIRDDKAFHNNSRNPQEHSAYQLYTTLVRLGRRGNGMSHGEVAEKIGIQAGTSFLWTMRTLEAIHRSLGSKNCISWPDPDERKRIHREFGLRSPFRKCVGLIDSTLIEMEYVPGREDKRLWYGRKDTYGFNVFVVADHECRICLIQSGFLASSHDQRVYHNTRMFQEPQDFFSDGEYLLADSGFTPNPNCLPNYKNNAGGRNRLAGAARDHKVFNDHVKKVRVRIEHTIGYWKARFQSNKLLSPQLKSSDHHVLNMSVWIVVTALLHNWVIDHENLEDEEIIDPNDLEEIMREEAVASDRLDQEAVQELTEAERRDNGWRREAVRKQIEDMQARGQNVAYVDPELPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J903</accession>
    <name>A0A1E3J903_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme oxygenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031936.1">
        <property type="nucleotide sequence ID" value="XM_019176023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J903"/>
    <dbReference type="GeneID" id="30193110"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="40687" checksum="574E33B7BFAF26CC" modified="2017-01-18" version="1">MVHNACPFANMAAASQLHANLAASVPLTPSFQPNTPDPEKVPRPSGNNVRDHASIIADIPELDYTQPLSALLKLGTQRAHVKAEHSVGAAALVQGTLGLEEYIRWLAALWRVYDVLELSLQLNSSNPVLAPTYDPTLLARAPTLAADINYLLTLLPPDTTPVSLPASSQSTVATPLPPFPLPSFLQSIFDDAPSPLSAYVDHLRTLSESPITAPGLLAHAYVRYLGDLSGGQFIGARVKRSYGLKGDEGTSFYQFDFQKEGAAGGDESRAELKKQLGEIKDWYRRGMDEAVGEDQKLKADLVEEANLAFALNTDLFSIIRVPSSGEKAGSKIAVAEQPKAGVKDFITQSMWFVAAAAVGMLLNIYLGPIVQDWRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9A8</accession>
    <name>A0A1E3J9A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032060.1">
        <property type="nucleotide sequence ID" value="XM_019176147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9A8"/>
    <dbReference type="GeneID" id="30193235"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN97458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="439" mass="48081" checksum="55FAEB5B2EF24577" modified="2017-01-18" version="1">MATPELVAYLRSLDAVRNRSSQVYHLAVEGKLNHWHFDQAKLGDVADYCAKIIQRDFGTDYASIPPHCRRNHFITPKRNRITTLLSTPGFPPPSDPLARASALTDLYLVSVLLDAGAGPDWEYIEVDEEDKENVVWKGGRSEGLAVASYNMFKDGLFSHTDNKFQVTAEGLKNLTPKLLAKHLQVSTANPMAGLQGRTDLLINLGSALQARPDLCPTGRPGDLIQCFGDKITDNILPLADFWSTLFELLLPIWPSRTILPSYPDEALGDVWPCAALSSALDQAGAGRTEGDDLVPFHKLTQWLCYSLVEGIESQTGWKVDRGRGQTGLPEYRNGGLLVDLGALTVKAETLGEEAYSNGKEKPPVLEPSHPAVIEWRAVTVISLDKIHEILCEKLNVDKLVLGLAQVLEAATWKGGREIAKEKREGGGPPVEIVSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBB9</accession>
    <name>A0A1E3JBB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 (Mitochondrial citrate transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032008.1">
        <property type="nucleotide sequence ID" value="XM_019176095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBB9"/>
    <dbReference type="GeneID" id="30193183"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="245"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="336" mass="36191" checksum="5140D00B07A0E603" modified="2017-01-18" version="1">MSFSAYNTPARLQSVAPKDRDAALPLPKGNAGKSQAPLSTHLIAGGTAGLAEALVCHPLDTVKVRIQLSKTQNAAGSRSNGFFATGRHIISQEGPLSLYKGLGAVVSGIVPKMAIRFGSFEVYKSWLLQPDGSISPQATFLAGLGAGATEAVFVVTPIEVVKIRLQAQHQPVLAGPMGAMRSPRYRNAAHAVYTIVHQEGLAAFYRGVSLTALRQATNQGVNFTAYQQFKRWALDLQPQHAERGLPSWQTMSLGLVSGAMGPFSNAPIDTIKTRIQKATKVKGETARSRMIKVTSEMFKHEGVKAFYKGITPRVLRVAPGQAIVFTVFERVKKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBS3</accession>
    <name>A0A1E3JBS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032192.1">
        <property type="nucleotide sequence ID" value="XM_019175702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBS3"/>
    <dbReference type="GeneID" id="30192787"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN98330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="458" mass="51657" checksum="3E043F501D3AC603" modified="2017-01-18" version="1">MVFWNYRLVVTTSPGEVPDGWRPTMGALDGLEVKRGTHTPRYCKTCEHYKPPRAHHCRSCKTCWVNHCPWVGNCVGFFNQGHFIRFLLWVDIATTFHLLMMLRRVMAVAHYYIEPSLSDVLFLVFNFAACIPVWLCVGMFSIYHLYLASGNSTTIEGWEKDKVATLIRRGKIKEVKYPYNIGMYKNLKSVLGPQPLLWLWPQKMRGDGLSFPVNPEAGGESASDDWAGIVAPNRDLDGPRVGGGTPSSTAGGSGSGTNVGRGTGEEHHDCQYFWPPQDPSRYPNPPPRPSTASPFTYGDGFNPNLRPSNALRSRASRYHEHSLDPNDPNHTFEEGEGEEAYSSGEDRDNDSIRTSSSPEPYLSDYDEYNEGPLAPGERMTRVRRGSEGWEVMPVRGGWYAGGGPGVGYEEEEQGTWQEQEQRVWDDQAGEDGESWEGVRGSHRPWEDRGRYNIYYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBT9</accession>
    <name>A0A1E3JBT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032179.1">
        <property type="nucleotide sequence ID" value="XM_019175689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBT9"/>
    <dbReference type="GeneID" id="30192774"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="138"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="55705" checksum="384533346E6AD8E4" modified="2017-01-18" version="1">MPPSFLRKKPRHSNQTPAPKNPPAIRHSLSLPDLTTPLIDTSSWEEVPPFTFSSAQGDSPVSPRGPGSPVSPLGRSSGTRNRKPSMVGGHGGEVQFHRPFTPKLVINSSPHNVSWGGDFRVSAAQWGRDASGKAQGQGLGRPDVRQSMASVASRRKFINLMISSLSAPSPEQLKPTLNPAPTSRPQSHTCLSTHSQDRILLRLIDTPGLELCPDEDIVGGIAAATALGHGVGVKGKERERGVKGLLRILEERFKYTLREESKVQRRVGADEGLVHLVIYLIDAREVLRPEEARKPTQEIDWSCVGLFDDEGLQDPDHEQTDTETSTFGPKLSSIEIDIIDRLSIRANVLPILSRTDTLTVSELEAVKAAVQRDLSAAFSKTPGRGFGVFGSDEESLSDSINIKEEDMEVDQPDPRPPTPNSIHSTASLSAPGLPWSIFIPSPSVSGGPEVTAGVRQFPWGTATVLEPEHSHFGLLLDNILGEYTKVLRNKTREVLYENYRTERLLAKSQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEW3</accession>
    <name>A0A1E3JEW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_03262</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032497.1">
        <property type="nucleotide sequence ID" value="XM_019175394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEW3"/>
    <dbReference type="GeneID" id="30192475"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="101"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="206"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN99420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="517" mass="55591" checksum="CD6DBAFDBDE84EB6" modified="2017-01-18" version="1">MSLPIPAAPGRRASVSASDPANHIPIPANTRGIPQTSFSPQSPPTGASPIQKFSSSPSGSHMRGTSIGGAFQGFARQLTAFLPPSYPTEQGHEKRQGKTRILLLENINTDAANFLKAQGYEVDHVTKAYSEEELLAKLPHYQAIGIRSKTKITAKVIDANPQLLVIGCFCIGTNQVDLEHAAKAGIAVFNSPFSNSRSVAELVISEIIALSRQIVDRTAEMRAGIWNKVSKNCWEIRGKTLGIVGYGHIGSQLSVLAEAFGMTVIYYDVVPIMPLGSARQVEHLDDLLSNADFVTLHVPEIPDTIGMIGAEQFAQMKQGAFFMNNARGKVVDLSALADALESKHLAGAAVDVFPKEPGSNGPGFDGALGDFIPRLRNVPNLILTPHIGGSTEEAQRAIGSEVATALTRYLNYGTTLGAVNFPEVDLRAITTADERHIRVCHVHRNEPGVLKGINNILADHNIEKQFSDSKGDIAYLMADISGVGQEEVEGLYSAINGTKSNTLTRLLCEFFALSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFL7</accession>
    <name>A0A1E3JFL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032694.1">
        <property type="nucleotide sequence ID" value="XM_019175591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFL7"/>
    <dbReference type="GeneID" id="30192674"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="559" mass="61525" checksum="9700A42535D86916" modified="2017-01-18" version="1">MPPTPTDKGSSRNAAAHPYQRPAPSAPAHVSPSTSKASKKSKKKAKREKKESIVCQPTANSVTSLAGPSPDKKRTKKKRKSHSREMQPSDAPLAAVVPVPPKPAANAASCRDAGPSSIAPIVLPKKPVLADSETNVPVSSPAQTIAGDRPQKSSIDREVARMREEAKQREASRLELSRAHEEIEQLKIATEVAKKQQEDMQRKVEELEKAAAQGEEQKKAFDGVLQRHDATKNDLTEALSCNVCFDIYRDPYILSCGHMACKECLHQWFRSSASFRQPLVSGEISPLSDVSHRTKICHMCRCNIVRRPTRAFFLRTILEPLGLYNNTIEEGSGNQAGPSDPWHLTFPVDPQSHKLHDEADGIWRCPECLGEIADGACLGCELEFSESEGDEEDEGDWDHADGRIANIMSDMFEGVYRRVNEGLRNEGDAGDESDSSSESSHAWERPIRQSPPPRANPWLGGSDHDEHSGSEEDGYEDSFIDDDEPEALSGEDDTFLDDSFVDDESDERIPARGGPPPRVQTIASDTEDENDQPVFMGRGRRTNGRVVIADSDSSSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIL0</accession>
    <name>A0A1E3JIL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032902.1">
        <property type="nucleotide sequence ID" value="XM_019175170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIL0"/>
    <dbReference type="GeneID" id="30192249"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO00710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="287" mass="32877" checksum="63F2B57DEE15E827" modified="2017-01-18" version="1">MSKAVLSAAEKNKFKDKVAPAEGPKPRKDKVLLLSSRGVTQRMRHLMRDLETILPHTKKDAKLDAKSSLHLINELADLHSCTNTLYFEARRHEDLYMWMSRTPNGPSLKAHVQNLHTMDELKMTGNCLKGSRGLVCFDGAWEGEHWELMKEMFTHTFSVPRTSRKLKPFVDHILLFSLLDNKVWFRNYQIIEKDPLTPTGPPQSSLVEIGPRFVLTPIKIFEGSFGGPTLFSNSEFVTPAAMRASIKRDAGEKYRIRKNNENEREERKKKLKEDAGEDELARDIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY6</accession>
    <name>A0A1E3JIY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032997.1">
        <property type="nucleotide sequence ID" value="XM_019175265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY6"/>
    <dbReference type="GeneID" id="30192345"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24787" checksum="42413BB20C4A5AA9" modified="2017-01-18" version="1">MASPDRTPRDLSPDSHAAGSRPAKKPRTTVADLQRRQLDKLLANPEKEVVLPTGIVKKELRAPLDMMKNVQGSSAGAGSGEFHVYKQSRRREYERLRMMEEESKAEEEQAAFAKRQADRDAEAESKTAKNRAKRQRRKQGRNGSKPAAIENTPTGGGGLKRKIEASGPKIAFRRPGEDEDGEDEDGEEEEEVGPAPPHVEEKVEEPEPQRAVEETKITIVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRE0</accession>
    <name>A0A1E3JRE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033444.1">
        <property type="nucleotide sequence ID" value="XM_019174392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRE0"/>
    <dbReference type="GeneID" id="30191453"/>
    <dbReference type="OrthoDB" id="2576283at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="219" mass="23200" checksum="FCAE6EE3A5CF0F06" modified="2017-01-18" version="1">MPLIRLRDSDSDAEAARPSSISSYFFPLLLIILACAGYMYWRRSTRPSAPGIPLNISGERPGIRLSEDGPPTHTFITNNLSSDSLPSHALSDLPELPESRDQYRDQPQQLHSSESSSASGSAYVDHPLESAAPGMPMTRFSAPKPGSGAPNPLITGASTRKPKSGGVKGMRRSQRGRAQGVAVEASDDDESGSDSGAEMSSSGRAIFDIGDDDDGPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRU1</accession>
    <name>A0A1E3JRU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 830</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033631.1">
        <property type="nucleotide sequence ID" value="XM_019174579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRU1"/>
    <dbReference type="GeneID" id="30191641"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="266" mass="29236" checksum="53CF53B589AFFBF0" modified="2017-01-18" version="1">MDAKSLLRAKKAEARITHPYATYNASGVLRCSICAVPAVKQWDAHLLTKQHRTSVAREKAEKEKAERVKRPRGDEAEPSSKRPKVQPQPSTGPSNLPAGFFSAGNAPPPQEPEPEPEVEMSAPVVPPPKTGDADLDDFFASLADDTPAPVSSTAAPPTAATQAARRKTYQEDLIPGQASYEAAPVRNVPKEEEAAQEPEEEETEGERKERLEREEREEIVQRLEDEERAQEDADSRVTALKQRMELMKKKREARANAKGKGKANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRX1</accession>
    <name>A0A1E3JRX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033671.1">
        <property type="nucleotide sequence ID" value="XM_019174619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRX1"/>
    <dbReference type="GeneID" id="30191683"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130524" description="Histone chaperone domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53667" checksum="3C084AA251A3D33C" modified="2017-01-18" version="1">MSPNLKPMIPSLLPLLLSTTPRIIALAAQPGGPLEREEYTMGIARGQIEDAMGLIRGELGKKEWKRVVKRVVQEEISEQEDGGVGSDQDGQKEEQVPMAPTPSPSPSPSPSPLPSPSPSPPPPKHKPTTNKPKPPASSPPDISPISPKRPPASNSKRQPPSPIGRKQEPTVIEILSSQPSHPFSPPPPPRYGKKHVVIVDDEDDGSEVEVIEVEEEEEEEEEEEEEEEEEEEEEEEEEEEEEGRGGGGGEAEQDAPSQMSSVYDTTSQARRAAKSKAGVTPSPSPSPVKKKKKKKRANRGDGDEKKSMGSDLEERKEKKEGKGRKRKRTVEEDETPKKKPAPRSRAKKDPHEGLSAQEIKVVELKKIIVACGLRKRWSKELANYPTPSSQITHLQSMLRDDLGMRGTPTLGKARSIRVRRELAQELDDVKAYEKERGRSADQRGNKSRSTSDDESTATEKASLHDKLTKEGVCADAIFGYRVLWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWJ7</accession>
    <name>A0A1E3JWJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S small subunit ribosomal protein S21e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033771.1">
        <property type="nucleotide sequence ID" value="XM_019173964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWJ7"/>
    <dbReference type="GeneID" id="30191017"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="139" mass="15388" checksum="3CD7A584B410631C" modified="2017-01-18" version="1">MGRKGEVLLESLVHGSYGRDGVCKCGRERLGIVSWNRWRRRIDIWGLSLILSLENDKGTLVDLYIPRHCSATNRLITAQDHASIQLQVADVDADGKAIKGSATTIAICGRIRAQGDSDDSINRIATKEGLLKNVWSYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWX0</accession>
    <name>A0A1E3JWX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear envelope-endoplasmic reticulum network protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033948.1">
        <property type="nucleotide sequence ID" value="XM_019174141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWX0"/>
    <dbReference type="GeneID" id="30191198"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="210"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="44333" checksum="8B910DF78177A2F7" modified="2017-01-18" version="1">MSAGLEGLRELGERVLVNAGISPPEEENDHGEEGSEGEGLVDPVTRGPEGAESLEEVPPGEDEFAATVSGEELQLDLGADEETIRAAGPDPNFTFRLRSAPQRNNEDGVSSGRSTPSRKPIPFQRPPSPTSILENPISPSPVSQLRITPPGPDEKPLQPAPRKASGGKLLANPISTSLLDPSVPAPASNAESTLFRKPSPRLPKAIPTTPFHLQKTLILDLDETLIHSTSRPLNYPGGSSGGGRILGLSLGGVLGIGAKGRGREGHTVEVVVNGRSTIYHVYKRPYVDHFLRKVAAWYTLVIYTASMPEYADPVIDWLDGGRNLFAKKLYRESCFQQPNGSYVKDLALVEKDLSRVCFMDNSPISYTNALPIEGWTSDPNDEALLHSIPVLDSLRFVNDVRRVLGIRGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZD2</accession>
    <name>A0A1E3JZD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033917.1">
        <property type="nucleotide sequence ID" value="XM_019174110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZD2"/>
    <dbReference type="GeneID" id="30191167"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="4">
        <location>
            <begin position="71"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="620"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="3">
        <location>
            <begin position="749"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="951" mass="103987" checksum="11570430756D2D76" modified="2017-01-18" version="1">MAATADPHTKKKQRKQPRPAPPAAGPSTSQQPSTGRLFAPFRALGYVTDEIPFAMFVHTPNGALATPTVNVTTSVGRSWLMWDAARMTLVFAGPDSGDKINGLTMTGTDIYASAGPRVIKYHRGKEVAQFDSPDGSTLGKMLIFGEDFLVLKNDGTGVFVYDMATRHLKNQITFHSSFTATTIMHPATYLNKVLIGSREGEMQLWNTRTCSLIYTFPHENPSEPSAITTIVQSPAVDVVAVGYQDGAIRVHDIKHGDLVMQMKNDDGAVSALSFRMDGPPILASASVVGSLAVWDLSKGGRILHTMRGAHDQGITGLQWVQGQPLLITSSADNSVKQWVCDSPTGMPRLLKMRGGHHAPPSCIRYYGEDGKQILTSGKDRSLRYTSVVRDSRSFELSQGSLIKKAIGMGVTVDTLKLPQISSISSSSTRSKDWEDVLTAHTEDSVARTWRVQDKRLGAWTFDLEEGYAQSVCVTACGNFGLVGSSTGEIKLWNMQSGKERKAFALSGAAPGNTKPKIIAQSKNGTKPKAVKAKDAKGGKSIKAITGLVTDALNTVVVAGTLEGKLYFFDFHTTKKIHEVQLDSSITAISLHRDSGLIAVTCDDLLVRLVDIETQRVVRELRGFKGRILDVIFTPDSRWIIATSLDSTIRTFDIPTGKLVDAFKTSSIATSVTFSPTGDFLATAHVDSVGVYLWANKAQFTDVALRHLDEEDDVVEVALPTVQGLDEDAAIEGIDPIGAPEYTDIYTTPDQLDSQLVTLSLIPRSRWQMLLNLETIKQRNKPKEAPKAPEKAPFFLPTISGLETRFDLSGVDANKDEQDKGQRLGLAGDWLESDFTRKLSAEKEEGDYNSFFEYIKALSPSNLDLEIRSLVSLDHLATFLNALTQRLKSHRDFEAVQAILSVFLKVHGDVLIANGEVKGALQELRNEQRRESKRLRELVGYTLGTLGFLRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG8</accession>
    <name>A0A1E3JZG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Enzyme regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033957.1">
        <property type="nucleotide sequence ID" value="XM_019174150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG8"/>
    <dbReference type="GeneID" id="30191207"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="42216" checksum="95EA08EEC1EF775E" modified="2017-01-18" version="1">MSDPAPASDPAAADVTQDVTPTDTEPSTKSTKPRARLGPMEIVQLPASDSEPEDDDEDGDKEDDGEGGDPDFLKSYPEDTEELHLLHLRLKTPTLIPLNFPRFRKHLTRLCLRQNELTSPLPSEAFEGLTELEEIDFYDNRLGPVVHDDELKGAPNVTSVDFSFNNLRHAPKLVSLKKVDTLYLIQNKISRVEEGELDWCADTMKSLELGGNRIRAIENLEKLVHLEELWLGKNKIRSLDNLSTFSNLKILSIQSNRITKLENLEALVNLEELYLSHNGLTKIEGLEHNTKLTTLDVGNNAIEEIENISHLQDLEEFWASNNKIANLRALDTQLRHLTNLATVYLEGNPCQSNDQGGYRRKIMLALPQIKQIDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZH7</accession>
    <name>A0A1E3JZH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034398.1">
        <property type="nucleotide sequence ID" value="XM_019173693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZH7"/>
    <dbReference type="GeneID" id="30190743"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO06298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="32443" checksum="1BA4EAF7DDBDA4E0" modified="2017-01-18" version="1">MPVPQVTLNDGTKIPRIGFGLGTAHYGKECTSHLLSALQTGYTYIDCAEMYANGSSVKDALKQWDGKREDLYILQKCGGGEFGTKNPKEILERLLADMGIDHVDLYLLHSPLLFSPDYTLSEAWAIMEDLQASGLTKSIGVSNFREEDLLEIQKTWKVVPAVNQIEFQPYNYHAANMTRLFDLCSSENITIECYGPLTPLTKAPGGPVDPVVSRIATEKGYETSQVLLNWAAQKSKGVVVTTSANKTRQTTQLDAIREKEPLSEAEMEEISEAGKKQFKRAFMEKVWNAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZP9</accession>
    <name>A0A1E3JZP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L198_01498</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034366.1">
        <property type="nucleotide sequence ID" value="XM_019173661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZP9"/>
    <dbReference type="GeneID" id="30190711"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODO06266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="41159" checksum="7ACB8710250357C1" modified="2017-01-18" version="1">MDAPVASSSRHPAPPTQEAVDAYANVSFEAASQAQILRAHQRDTAQVYRLTELVSEILRSLAGTRWLAHKQTLVDLLVRGVYLTLTFGRGSQTLGEEYTDILPYSTRRRNLPSRRSRSLTILLLLLPTLLVSPASTNYIRPAPVQRPDSGPESRWTRKREKLAKFLESPVGKALPELHMILFLFRGRFFEFARRLTGISYISTLPPRRPEQRQASYEPLGLLMLLPFLYRLLPRRQPEDQSAILPQASRGTLAGDSEESPILAEPVGAPKTAEQTVLMSSSAEYDKPNTYLTQKAIALPERQCTLCLEPRGTGEGSGGTVAVTECGHIFCWGCLGGLEKVRLDMRGRAVLTPGIAGMSAVSAIAENGETHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZQ6</accession>
    <name>A0A1E3JZQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034037.1">
        <property type="nucleotide sequence ID" value="XM_019174230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZQ6"/>
    <dbReference type="GeneID" id="30191288"/>
    <dbReference type="OrthoDB" id="2564234at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="65513" checksum="B35345F7791FBC05" modified="2017-01-18" version="1">MNIQLDDVSPQIAYYAAAGSASGWIVDHTSDKASMVSSYSKGTFHGTYGDGDYMVYKFNGSGVAIYGAKRDNHGIYGVSVDGGDVLMSDGYSATTLFKQVLFSRNGLDDSEHTVTITNYPNAGTSAVAGNHWLDIDYIQSTPPSSTLLFPETDFVSQATSSTSGQVYTTMIDDANPVITYTSWSTYVDSNRNVAFFNLTDHTTSTEGSIMTVPFTGSSIQLIASLNDVHGNYSVSLDGAEAEVFNSNFFTPIYQVPIYTASGLDEGDHTVTVTNLGSGTRSILSFDYAMVNSTSPPASSTSAIVASTLASTAVGSDSTTSNGAGTASSSTSSSSSSAVVAGASEDTNGGSKTNVGAISGGVAGGVVALALLAVLAFWFFRRRRNSASSSQFSEDGSREGSYFDYAPGPAGAHSRKTTPSSRNMVDLGSSRGSAGRHTPRSMLWSGGTPRTPVTPFVDHPNQPQQHSYDERSYHPPPSSGGSSSGGGTFLYNSSAPLSPGSQDATLVSNATANSPFFPSMPPPPGSNTSSYPRSAHQSSRGAMPATFTPFTGTGGASETLMQQGQGVGPATVSTAQLSEKSRPGTGGSGGAPTLPRMNSMGSFSALSHFTAEQAGGDRQPPEYVQAVQPRGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZQ7</accession>
    <name>A0A1E3JZQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034375.1">
        <property type="nucleotide sequence ID" value="XM_019173670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZQ7"/>
    <dbReference type="GeneID" id="30190720"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="43843" checksum="4D7F0CEA7261F18D" modified="2017-01-18" version="1">MSNNTQSFDLRAEEDAARRLNVGRVLPTSGSASTSRAKVSEIVGRAFLRQKADAISKNHGVKFDDDATLYLTSAIESSLRSLLELTRTAQIHRTSSSHLHPPPLSEPPSKSAPPSASPKPLWSHSLTSHPASVLDALNRQNRDAEQEFRKQRMDRLARDAELQKARERRERAEAYARDNGLATPSGVDGNVAGSGDGSPAQSSGSSPSTPAPGTPTASGTKKKPPKKSTPSASTPASGSGSSRDLSAEVQHKMTNLTAMRSAGVGKKYNWMMGNAPSVSSPLAGKKRKAEGAAGGAEKGKGKSKLGMTGGAEDDKDEEEGRKAKKPRGIPIPVRRMVNVLAPPPTPGQSHNPYSSNPLQSQQTSGQGAGSSRQVEDDKALTLTDLVFALEHGGLGAAGGQGWGSTTGDALQGVWARGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZU3</accession>
    <name>A0A1E3JZU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034077.1">
        <property type="nucleotide sequence ID" value="XM_019174270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZU3"/>
    <dbReference type="GeneID" id="30191328"/>
    <dbReference type="OrthoDB" id="2560796at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="17848" checksum="E07BC3753C73536C" modified="2017-01-18" version="1">MSSSADHEKAKKAAAEKEKEKKEKKKAEEELKAARKKYMDKANPKTVDQLLGEKDLEKDYFKEGEWRPSWAYVEFNGDACLADVLEKKVEGFYVPAGTMLPLGAQMFEMTVVKYGGYFPEGTSFPGGVMVPMHARMVNLLPKETKKGAAKMEESLCLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K074</accession>
    <name>A0A1E3K074_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034600.1">
        <property type="nucleotide sequence ID" value="XM_019173895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K074"/>
    <dbReference type="GeneID" id="30190946"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="193"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="714"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO06500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113213" checksum="41F1C34AFB3C5F38" modified="2017-01-18" version="1">MPAPPTDPAAPADTPAQHRLVMDAPQDLEENPEQIELLSLRYRMERDRKRVKVYELRDASWFDRGTGFCRGVVDDASGEAIIVVEPEEDSPEAEEDAGGFLTRELLLHTKVERDDIYGKQQETLIVWTDPATSLDIALSFQDAEGCEDTWQFIVEVQKHLLTLPGNHYAMADPRLAWQPPSLANIRDQEFCLRAQAKSAAGRERAMEHILNEEYIKQLITVLEQAEDLESIVDLHALCSLMQTILLFNDNGIFEYILQDDIFLGVIGMLEYDPDFPDLKASYRQYFQENARFREIVHIPDAVIRNKIHQTYRLLFLKDVVLARVLDDPAFNILNGFVFFNQVDIVNYLQGSDTMLTALFAPFQSSPPGPPPADGQPGEPLDEKKRDTVMFLHQLVGIGKAIQLTPRMALYRTLLERGILHAVEWALQRPEAKVLHGAAEILTLMVEHDANMVRMHVFREEEKKERTLMVEIIGLLHTTKNGGLMGQMADTLRTLLEVPADTEVSDISICWDRLMSDVQSFIAKKEAPLSDTFNVYFYESCGALLFKPLLESSDFKSQPVTKLARNYTTLLQNLTELLSYCVTTHGHKSSYFILSNPISKKVVGLLYIKDKPLRHAALRYLKACLRTPNHFIHRHFVKNDLFEPLLTLMEDETTKDNMMSSACMEVVEQIRKDNLKTILNYLFDSYTDRLEALARRPLLRTCLVGLKARWEMNNEPPPLPPGLSPSELAASASKTDVGEGDSWIEGEKREEDYFNGSDDDEGSSPSGPSKSEEGSVPAKRKRHPTTSSSGGSKKRTLRSSTSSSSLANSSTTGSAGPSSGVLGLDYDDASSDPESPFSQDQGGEDEDEELGTEDGAVPLTTSTSLLDRTISRAQALSPPDHSKPLTTTAPFAPVSISSTAKPDEKSSSAKEDEGMDIGEVTAKMREKRRREEEEEEEGFAGLVVGNKPRPVATVAARVSSASGGGTVGAGKGEEGTNPNMEGIVEEVDVGDGDKEGKGKSRKGVKEMGNKIRLITQKFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0E2</accession>
    <name>A0A1E3K0E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034583.1">
        <property type="nucleotide sequence ID" value="XM_019173878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0E2"/>
    <dbReference type="GeneID" id="30190928"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14842" checksum="B3F7CF5B05201684" modified="2017-01-18" version="1">MFFRAYDGTINHALQGLDQLALPTDQREWEEGIIELQPSATYENQPDVQEYLKLLGSDMAQDRDDQIDEGRKKLLDASQKGFGHFWAQLLSDPCIRAKIGHDVLDRTYTEHSEKYRWDSVLTIVSEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0S7</accession>
    <name>A0A1E3K0S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_01328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034197.1">
        <property type="nucleotide sequence ID" value="XM_019173492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0S7"/>
    <dbReference type="GeneID" id="30190541"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO06097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="692" mass="78242" checksum="1BD35817543D6328" modified="2017-01-18" version="1">MSSVKQCPQCGPHGELVTDQSAGNVVCMSCGQIIEEGILVSEVGFAEGSGGRISVQGTFVSNYATGVAGTRGGRGGQQNTENIKANGSAKIDEVARKMYLGSGISIGAKRFFSLAVDNKFNRGRKTSYIVASCLYLQCRLKRDARMLIDFSEHLAINVFELGATYLKLRSTLNFTDPMPEVDPAIYNLRFAHRLNFGPLVNTVAADASRLVRRFRADWMTQGRRPAGVCGACIIIAGRMSNFLRTPDEVAQVVKVHPNTIKKRLLEFAETDMAKKTVGEWRALSDAQLDAVSTEEKPPVVKQQARKREKELKKHLMMGIVYDEDEETENGDENDEDGPNKRAKLEKGKGREVDEADALQASAAFETTSSVDDEDDQLDPLAPSDYVSQLESARDDPASAREERRRASKALMKEVRGVDDGVEEDEEGMDELEALAEDVEKEDEEGEDEDEGEPSTQLNTVSQGNPKNTEFTDWDDEIAVLNFFERKYFAGEKDLYQNKMHDRIKMWFGARDPKEIHQEMEAVKRARWLREKGSKVVEEDRELADLDDEELEGWFELDEDTKQARARMWLSSNGKWLEEEKEKQERKAAINKAKGIDPSKPRQKRKRAAPHKGPHKNYQEAIASVVAQKPMSRRLNYDICRTLNVKPGTLFRDRQSTAGLQTMDDDKEEEYYDEEEEERGDDDKEETYEDYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2F4</accession>
    <name>A0A1E3K2F4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034835.1">
        <property type="nucleotide sequence ID" value="XM_019173109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2F4"/>
    <dbReference type="GeneID" id="30190150"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="361" mass="39781" checksum="6FDB25F5576E91CB" modified="2017-01-18" version="1">MGTNDVTQETFGSADLLCGGAFAEIKADDKVKESHVTDTSKDLFPEDQDQLAFPSQSSVLQNSPSSSVDATMKEFFSQVICEAQVNRRIRGIVLLFSICSVVRLTKDNEIHISHIVRRDAPVPGNTYTNCTASASMATMMAAMARLRSLDPHHPMQVIFDRRLAGPSVQIPTSSSTHLPSTPDKKQGSGRQMRESQSDHYMTCVFNSKLRFVPPTSQPSFETFRLEQVIPPDVAPDSSHAPPASSTHASVSNSHSHQIESTSSRATASSDKTIIPKHAGHFQTLRFGKLMGRGALWDVYELPDTPGYVAKFCSPYSVLLQRGYDNFDDLDIILNELVTDTLLSSDLWPVERVLGSGKYDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2N9</accession>
    <name>A0A1E3K2N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01704</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034572.1">
        <property type="nucleotide sequence ID" value="XM_019173867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190917"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="11">
        <location>
            <begin position="401"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO06472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1478" mass="166913" checksum="BED012973771F14C" modified="2017-01-18" version="1">MSTNTQRHILHRTVPLICQALITSPDDETVWTEGFRILSNTKLQQVLPLTTSIWLPLLLKGLETTRPRSVIEEALKLLVGAAGTLEPMKSCIIKPLRALGKSGDMGVMEYLTKAVERLDITVRNEDNQLIGKGPRSNTSYQGQDPKLVSRVETATQHPLLAEILAHNLPPKPRSVQHAWTHTLLSSAHDSPSVWLHNFYQATLEASGIPEVVITSRLGSMVHGDIFQTAFFKCYVSLEGDPMFMSCVDRALIDLLSDRSISRDILVVILDLLAFFSKERKSPLSHGVQEAARACAFESFRGALNQPLPGVILWYMEQYTEMYPTQENVSNIVEANISRVGSSGYDAAWSSLLWLENDWNVEPDPMWITSLSHWQQGLDAQIKIDETQETTMYSSFNIRMICYHALGDYQKGYELAQNYFEGLNDIERRTSAHWATAAAWHMGDFDTMADYLAFHPKGTSKSLYKAIIDVRNEQYASAFHHINKAQSLSYDELQVKLGVGPQVALKSLAKTEFLVELQEAIQYKSQPELRESILNTWKSRFKRSHADANSWLRRLEIWTLACPPTTFELQSCFLNTAKLCESAGMHEAAQSIIRRTAPEVTPPGCKVEYTKLRFDWKDAFQQRDQAAMEAVLQRLNDHTDRYLQHMGLDRDKIEASGLGLQPVSDVISNQERLTKLIVARRYYRLGEWTAVLQGSDWLQDENSLVLTYTSLASKLDESWYGASFSLAERSVTLFESSGCSKSDGVAVGSYIVPALRGLFQASRTKESPEFVIKALLRLVTLWFSFGESQAVLVEVENQLNITQVDTWLAAIPQLIARLGTPHKDLQYMLINLLKTISSRYPHAVIWPLLTATQTQKVEHHEAARVIMNFICTMPDGTRLVDQAELVGKELIRVSISLMEKDHGKGLARTSKVLGRRHDQATGASLVVKMQYPETPDEEKFVQRFGNVLLRINKTLLRYRSTRQMSLVNSVYTELYKLWGELDAHLNQWKVTGNKLHLGSTAPRLLTLRDCILTVPGKYDPHIKLDDQAFIDSFHPTVHLLFSKMLPRKLVIRSYMADHTFLLKGNEDLRGDERIMQLFSLINTLLNHRPDAFSRNLHLLPYEVIPLSPSAGLVSWVPNTQQLQSMIQTKRDKYHQQWLNDAETSSILGYDPENGRPKPDQARMDVSAEIDRYDKLPVNTKVQRLKSALSHSDQSDIRDVLWQRSPNSDVWIRRRTNFARTLGVGSFVGYIIGLGDRHGSNILVDQLTWGALHIDFGDLFDVAQERSYLPEKVPFRLTRMMTNAFELASRGGLETPGSRGSYKQASLIAMGVLRDSRSTLLAMLEAFLYDPLLSWTNSGEPSSNVDTTGAPTPDKEAQKVKSPHRPSYVVPQSVAQSVAVNNQSGDMEGYYKFENSLVSTYMQTDSYMAKVEGNGMTNGRALQVLGQIEKKLIGFHKDNEQPLSVNKQVQKLIEEATDLKNLSQADASTVGYTLGWMPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K386</accession>
    <name>A0A1E3K386_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein 8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034973.1">
        <property type="nucleotide sequence ID" value="XM_019173247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K386"/>
    <dbReference type="GeneID" id="30190288"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="96" mass="10809" checksum="F2952E19A645D7A2" modified="2017-01-18" version="1">MADVDMNGSGKDFSWATKSVEGWIISVTNLHEEATEEDLKDFFADFGPVKGLNMPLNRRTGYVMGYALIEYETRQEAEKAIAETDGTQFLEQTIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3K3</accession>
    <name>A0A1E3K3K3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035098.1">
        <property type="nucleotide sequence ID" value="XM_019173372.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190415"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1935" mass="206917" checksum="46540D5FAA284885" modified="2017-01-18" version="1">MSNIIENVVGGVRELVTLAEGYLSPPDADESASEGSVPSRRPSPAQPLSIPTASTVSAATTSSTTTQLSTSKFSLPRHASLIQTFDVPSGWIHLPATYLFGDGGGDVGQRQVRSFGLRNVGGEGRDVEVEVESDLKGQLVFWVGDDEKSIPSSSSSTSSLSTTTGSPSLILHMPPSSTTMIHLAFQPLLSNRSPVPSSPSFSDNDGGFTPRVKPVLDLTDSGDSGRLSPVGLDDAASGNGSDGVSVSAGSSQSIAGSLNSQIIPESTKRGEPIHRAFSVHGSISIRAVSALPPPAPPSELSHQMIALPFYATVCRSFFTAGAISPTSGLVSGPQQSSGELVLDFGGENVVGKRYHRDVLLVNRSEIELVWGTMVVNAPDKEKVWFELRDLDSENVFGVDHSAGPVPLPALSSRHLRLSLHSKLPVQDFSFSFLLTNPHQPGNTLTCLALGSILPSPPDESLQILTGPTLDFGKATDKVWSRQVIAVRNTGDRAVDVRFGKEEGYEVVFRLAGVAGEDVEEEGLVPIDSSGADGSGLGRVPKPVLARGTSRDKYSSTRASSRDHPSNASGATISETAYSSSLQPTTEEDPESLASGSPSSRSLSRTTSRGSSSQQAVGYDGFGHESEGEEVEPPFFGGSDLPFVVGGSVEDGDGNSAEREYTPTVPKPTPAPTTEEEIIPNQIEEVTMRPGTEYRIAVLHRPRPPSAASFSSDGENWEENAGKLRKSSFKVFLDAVPSSVRSNHAHHGSNPPGKSRRTISCSIMSCTSLIRLSSGNVIDFGQVTVGASKTTTIKIENLSELEARVEIAAMSKVLSAEKGLIMIPAKGTVEEKMEFFPRRINEKYEKQIFVRNRLNRANDQLVEIKSRNVDVYNLTLHSHLYRILTPSGSNFLDFSSVVINYPTVRTIHIENLSQAPLVLDLSASQPEDIGLFVREEDSIAKVRPGLMGRYAVEAQDYEQTSADGSGNGGNGGGKGKEGKGGELKERFMEELNEKSVNGKAAESKGKGKKGREKSETGGPKKEEGERPVGVSVGAALKKGSRGKPVQLYGNSVVFKDRSLLQPHEYLDLASGPPIASHRFSPRSKRAQLLESIEWEDKSKLSGQHPKVPKLDFAAGAKATGSVGKEGKKKKANGTAISGGGKEHQHQVAKTAPTTGEHTPTTPTKRPHLGSLALLNKLLPQTSPSLKSPALTAKRVEPLLELPPADTADVGKMSIDQLLAAVEAHDAKKTSMTHTTLEEEEAFVKRTISLRKELQGLVGSGKLVPARTLSVGPGQSRAVVVIMTPNPSIRPHISTRAKRADSRIFIKLVEFDKSLLNAARINAAGSRPGTPGGDLGMPEGAELPIRDLIIRSSCVRSVLEVQQSSINFGACDKGEVKSKTIVIHNKSDTIGLFRLRTSGSIASGDLKLGLGRYGVISAFGRKQFDNFSFTPSLVGNYQETITVENVLDSWNDQALAVKGIVRKVPAFRVEPVSLDFGVAEKEKDQDKTQSFVITNILRHERTFLVSVQQLDPSSFARIHLTRDEHDAGTALSKSEEEELEAMMQKLKIARRKGKAEKIVKYETRLLELGVPKDQLGAGMDGEGEEKEVDGAKSPAKKLAELATSVLVPAKEEKINIPSECITSLNLNLLPNQKTKILVDLIPRTALPPAEGGGEEGETLADVQACITVHDRKNTDETVSVSVMAARTGKPLGSRSIEASGSGGNEDEPSSPETASQTSFDPVHLALIRHCLKLTLNCEVSPTAFCVGSTLFLPAASQYYGVLKPYFEAFPQSVLGEAKGLILADGWSRQIPGNTHAEANALTNLQARFAEISGEEGEEDDKSVVTLSTLSLEIASDGEEGKKEEKGKGEKMPRVEEVLKDAECVATMEPCSYRTSGGPSCALELVKAGVRAVYLGVEEPPDFVECEGARILQSGGVQVVRVVGLEEECLKAARRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4G2</accession>
    <name>A0A1E3K4G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCY1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034874.1">
        <property type="nucleotide sequence ID" value="XM_019173148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4G2"/>
    <dbReference type="GeneID" id="30190189"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="925" mass="99486" checksum="5765A7C08809DF8D" modified="2017-01-18" version="1">MFAIFQKSSYLAAYTVHSPATPNPSSTHLPSLAASTSAQKTFNVGLWKVIPATHKTTGKEVSLWMLEKRVLDGIRAGTAFGGIPGKDWVIEQLKKEASALSRLRHPDILHMVEPLEDSRSEMTFMTERITSSLSSLAADASASSGSYRSGRPPTGEERGQGELDLDEVEIQKGTLQIARGLSFLHTQAKVVHLNLGLEAVVINAKGDWKLTGLSHTTPLSQPDGSATKYVFPEVDARLPPQVQWKLDYLAPEYALDNSLNQSNDLYSLGCILYAVHMGGKPPFENRGSMQSLRENIENKLVTREWASGSRWDRCSSELKDLLPRLLTRHPSTRLSLPSLPPHPFFSSLAISTLSFLDPTTFASKPREEKATFLRGLVRVLPGFSERLRKGKVLLSLLEEMKDSYLLPFILPNVFEISKSLSKEEFNTVLVKLQPLFALKDPPQNMLTLLEHLTLFEEKTTPQAFRDNIMPLIYNSLESEHLPVQERALKTIPHLTSILDYATVQNVLLVKVAIVFRGTRVLSVKVQTLECFGAMVGTLDKATLTGKLVPLLAKIKTKEPAVMMATLAVHEAMGSKVDREAVATLVLPQLWSMSMGPLLNASQFAKFMAVIKTLGSRVEEEHSQHLKDVGRIEAQTASLAAANSAALNGGSGHNQGGEVDFETLVRGSNSSPALGFNVNSTSTPVADSSTTITDPWDDENWLSQPSDAGLSSTFPSLSVNNTASTFPGLSAPASPKPPATNGMASLQPTKPIGAPKLKAKPVPAASFNSSAFAPPPSAPSTSTTSQPTSMSSLPPLQPTSSSFGTLQPQQASRTPSYTSTTAGSGGGGGPNYNISLSPQPPTQSSYQSSPLSFMTPQPAQATRPLQPSQPLQPARPAIPTMQPVVSPPPGWSSGVMQPTSAPKPTWGKGAAASGASSDWGDFDPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4K3</accession>
    <name>A0A1E3K4K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034649.1">
        <property type="nucleotide sequence ID" value="XM_019172923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4K3"/>
    <dbReference type="GeneID" id="30189964"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="843" mass="94480" checksum="FE2E716DACAA3729" modified="2017-01-18" version="1">MPDTFLDHKPFLSDAFDVHAYTNAILQGRQYRPDDEENDAATEKEKGDSDVGSELARLNFGIEDVTKQLRQEITSSHHLLLNHLTTSLSLSSHLTPIRTSLTSLSTSIDRLHSKIHTPYTNLSTLVKRQETLRQVSEVSRRASRFVILARRLERQLDQMNNVKEEEGKEESDESEKRRELAKAALSCAELDALLKEPATEEDDGEVQISLMEIDFVRAYAPLVDQARDTIIEEMESMVVAGLQDLNQSLLSSALQTAHNLRLLPDLVSNLLADLNDAVTLRVTKAFDSAAIGKEVAAKEGAASQSAIKFARSRPATEPTSSTAPQWINVLWKRLERVIEDVANCCVKVYTLEKILKVKRDTVTQVEFLDEVMKRLEEKPSFTFWTTLAKAFETQSKESSRSTWIQLALSTGYPRLLRLFHDFFAKIAVHTDTVYTREHQSPEAVLVLRSVSTFETLYLSRSTERMNNAVTTGVGQYLSGRGHPPGPGEGVNIARTMTNELDSARFDPLLVRTVARNASKVLDGFVKKIDGMLVKDFTANSMIGPNATPSQQINAQLVGCLYHCWLNFVYVKQDYIGKVWDILTPSVNSVETTFKRITDALDAALRKEITSILSRIHRVDFAKPVDPMSMGMDTGGGSPYMQDLVDKLSFAKREILSRMGLGEYMKEWVLELSKFIIRTFLLHGSIARPMGESGALKLTGDMTELEMSVTNLLNTGRVQGSRGGARVESVGEEYQALRSFRTILFADLDTLADPVETVHIPPLIVLHHIIVRSPLRLPHEVHGWSEAEYILWVGKHDDEKPQLELVEKAVDAQIESGGQDGEEEGVYVKLIREVLVHARHEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K556</accession>
    <name>A0A1E3K556_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035191.1">
        <property type="nucleotide sequence ID" value="XM_019172249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K556"/>
    <dbReference type="GeneID" id="30189273"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="300" mass="33548" checksum="72BF74E0611AFE06" modified="2017-01-18" version="1">MPRFYENKYPEVDQLVMVQVQSIEDMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVVVVMRVDPDKGYIDLSKRRVSAEEVVKCEEQYEKGKAVDSIVTQVAKKGGVTPESLYEKIAWPLHRQYGHAYEAFKLSISEPDVVFGSLGLDDETLTDLRAGIARRLTPKPVKVRADIEVKCFSYAGIDAIKRALTAGEAVSTAEVPIKVRLVAPPLYVMSTTSTDKNGAIELMEKAVEVISESIKADKGDITIKMKPKVVSETDDLELKKLMEQFEAANIDQAGDDDSDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K597</accession>
    <name>A0A1E3K597_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035231.1">
        <property type="nucleotide sequence ID" value="XM_019172289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K597"/>
    <dbReference type="GeneID" id="30189314"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130764" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="463"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="579"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="695"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="799"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="896" mass="89291" checksum="3B97C4A82CFF3CDB" modified="2017-01-18" version="1">MSSVIPLLLLASLVNGAAIRPDTERRDLFWSWGTSSGGYYTGQGNSGSTTSSSQAATYLAQAQSSVSGLDQGWSAAGCYDDSNSARTLASASTYSWWMDYSTCTTFCGNKGYTYAGVESSNCYCSNTINRASTIQPYYKCSGTCSGNWFEDCPSNNYINVFTKGSTTTSSAKTSSAATSTAKTSTTSTAATSTAKTSTTSSAASTSTVKSSTSAASSSLSSAASSSSSAAKSSTSSTSVAQSTAAQSTSASSSSVSKTSTAAVIPTISVPAVNTTSVISAAQNVVSSAVVSVASEASQVVSSVSAQVNTTSVASQIQSVASQVSSAVPAINTTSVVSQVQSIASSVASSVEAVPTSVASSVISEVSSFASSASAQVVSAVANVTSSIASDIANATSAVSSIYSEATEAASSAVSSIASDISSAYSSVLSEESSAVSSVVEEATSVISSAAAAASSAVSSLPTGWAVTACIGEGTSGRALPATSTSSSDMTQAKCVSYCSNAGYTLAAIEYASECWCSNVLQNGASLTKTSDACTMPCSGDSTSICGGPSALTLIANATAIASLNADLTSGTVSLPTNWAVPSTSCIAEGTTGRALTGSSYSSADMTLAKCSSYCTSEGYGIAGVEYSSECYCGNQLNNGASLTLSSSACTMACSGDSTTMCGGSGALSIAVSSTITSKLSSDLSTAVVTLPTGWEAASTVCIAEGTSGRALAHESYASDDMTLSTCLSYCGNLGWQYAGIEYGRECYCGDYLANGASLDLTATCNVACGGDSTETCGGGNALSLYVNPTLALDLTTVLGYNLQGCVQEVTGRLLSNNSFASDSMTVDMCVGFCSDQGLALAGLEYGRECYCGSALTSAQVLSTQCDMKCAGDSTESCGGADAIKLYLAGDSVLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5E4</accession>
    <name>A0A1E3K5E4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035281.1">
        <property type="nucleotide sequence ID" value="XM_019172339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5E4"/>
    <dbReference type="GeneID" id="30189369"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="687" mass="75147" checksum="EDBAA4C863EB16A9" modified="2017-01-18" version="1">MAPRKNKEAASWEVNKDTPKPQGETRPRRAYCVKELVTEPAPGVTTVHDLLLYAAKTHGDKKGFAARDVIKVITEEKEVTKNVGGKQQKEMKKWNYFKLSDYDWLSYNQFLDFAKHVGSGLRQLVGEDSRKEKFFNIYGQTSRNWMLVAQACAFNAVPISTAYDSLGPDGLRHALNEAEVRGMFTNADLFGTLIKVIEQTKTVDLIVYDGKADEKLLEQIKGVREGLKVIHLDEVVELGKKQPVEAIRAKSEDVYCCMYTSGSTGTPKGVLLTHLNVVSAVASVWTLLYEYLTPKDSYLAFLPLAHILEFVVENSFVFAGLPIGYGRVKTLTDASVRECKGDIAEFKPSIMVGVPAVWELIRKGILSKVDQAGGLKKSVFNFALKAKTAANAYGIPFVAGLTDAIVFDAVRAQTGGNLKIMFSGGGAVSKSTQQFLSTALVTMIQGYGLTESTAMAAILNPGWMQYGAVGGPVPAAEVKLVDAPEAGYLSTNDPPTGEILVRGPAIFKGYYKRPDLDKEAFTEDGWFRTGDVGQWNKDGTLSIIDRLKNLVKLSGGEYIAIEYLESIYKSCPLVANGAVIANGEHNKPAMVVVGHPQNLPAFAKKNGLGDSEDLEHLCTDEKVVEAALKELNAVGKKAGLKGMELLEAIVLVADEWTPESGFLTAAQKLQRKTIDKHYEDRIKAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5R2</accession>
    <name>A0A1E3K5R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_00220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035347.1">
        <property type="nucleotide sequence ID" value="XM_019172405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5R2"/>
    <dbReference type="GeneID" id="30189435"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000207">
        <property type="entry name" value="serine/threonine-protein kinase dst1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="330"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="536" mass="58663" checksum="37B4E10E7075CB10" modified="2017-01-18" version="1">MSTYSQTNPNNPHADPELFYVRQNRIGKGSFGEVYKGYDKRTSLPVAIKIIDLESAEDEIDDIQQEIQILGQLDSEFVTRYHGSYLKGSHLWIIMEYCSGGSCSDLMKAGVFREEYIAILARELLRGLDYLHEEGKLHRDIKAANILLTANGDVKLADFGVSGQLTATMTKKNTFVGTPYWMSPEVIKQSGYDHKADIWSLGITCIEMAMGEPPYADLHPMKVLFLIPKNPPPQLDERFSRPFRDFVSLCLQRDPRNRPTAKDLLKHKFIKTARKASYLTELVERYEQWKAEGGAKPSDDGSGGMSQEPGYGPAADALWDFGTVRNNLPGTVSRAAGRTVPPTASLSGTAQTRNTSTPTKSTHSATPTRSQTEQSLPPSMSGRALPPTPSRGNPSYNNGTPSYNNGTPNSVISGHSQQGSATPTGTRAEGGDVMYPTVRGAVIPPGSSVPVAGQAQPEAQAKQQQHIDDEGDEEVMLEGVIIPAINNLATRVPNDYARATLARLREAFIEAERSIPGVTSAFVLEIVENVEQVEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K662</accession>
    <name>A0A1E3K662_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
            <ecNumber evidence="7">4.1.3.27</ecNumber>
            <ecNumber evidence="9">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_00078</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EC" id="4.1.3.27" evidence="7"/>
    <dbReference type="EC" id="5.3.1.24" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035210.1">
        <property type="nucleotide sequence ID" value="XM_019172268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K662"/>
    <dbReference type="GeneID" id="30189293"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16 24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="21">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="21">
        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="22">
        <location>
            <begin position="225"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="23">
        <location>
            <begin position="544"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODO08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="748" mass="80232" checksum="7F1C7C7AE0968F8C" modified="2017-01-18" version="1">MGFTLLIDNYDSFTWNIYADIAAIGGNPYVVRNDKITLQEIQKLYETDQIARIVISPGPGHPRTDSGVSRDVIQWGMGKLPIMGIGYAGEIMHGKSSLVTHDSIGCFHDLPQDLSSIRYHSLAASISTIPQCLQVTSTSKESGVIMGVRHRVYTVEAVQYHPESCLSEGGKGLMANFLKLKGGKWGGENAWCGVVPEGEASTEPAEPKKVTSSNGTGAPSLPTILNKIHSQRLQDIDQSRTILSTTPDNVSKSIALHTAPPLISFYDRVKNTPHTAIMAEIKRASPSKGDIAPDASAPEQGLKYALAGASVISVLTEPKWFKGSLIDMLAVRNAVSTLPNRPAILRKDFVLSTYMIDEARLYGADTVLLIVAMLDPDLLSTLYNYSVSLGMEPLVEVNNPKELELALQIGSKVIGVNNRNLHDFNVDMSTTTRVNAALKGRGDVILCALSGISQPKDVETYVKEGVKAVLVGESLMRAKDTGAFLRSLIGLPEPAQKQVQEQPLVKICGIRSAKEAQLAIDAGADLLGIILVPGTKRCISLDTAREIAQVVRTARASRPFPSSPAIPSSPEPWFRHNLTTLSSRPKPLLVGVFQNQPLASVIHQTTAIELDLVQLHGDEPQQWAQFIPVPVIKVFRVDDEGKVRGGEVARPGQNSFILLDKGTAQGGGGEGLSFPWKVAKSLISAGEANSLAHPLPVILAGGLTPENVGTAIEETGDGVWCVDVSSGVEGEGGKDEEKVRAFVKAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6I0</accession>
    <name>A0A1E3K6I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric-chelate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035649.1">
        <property type="nucleotide sequence ID" value="XM_019172707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6I0"/>
    <dbReference type="GeneID" id="30189740"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="290"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="635" mass="69951" checksum="39F458F271A5475C" modified="2017-01-18" version="1">MSNTKRFIPIPSQYAIYNSYDVDPKWQIKFTIIWTSILAFSFLLSLPYVVHHLRIGRLYSGWAIQEYLDPPERDPAPAEPSKALSNQQTFHGRVCKGIGAMVQSATLLTLPMPNISFWKTQVSDCCRRAYFTLSVWQTALVGGYMSAVVACFVVGAQLTQNPNRPGFLALAQLPVILLFSLKSPIPLPIFLPSLSYEHYNFLHRWAGRTLFLSVSVHGGMWINQFVTTNQYDQLSAEKSKRGMLAYGMMGMVVLTSLKPARRMCYQLFWMAHVLFFLGFFAAISYHTPYSRPWVWPCVSIYTYDLCVRMFRYRIKDATLIPIDSTLTMIHIPDCDAGWLPTQHILIRVLSGSGVFESHPFTITNAPATAFSAAPRGIILYAKVAGDWTRKLHNLARDTTCEVGDEKECLLQQQPSQESGLQGTDHPGRKVQIVIDGPYGGLKMDLDQYEHVLLVGGGSGITFILGSVEEALRVREKGRGPAKVDVAWVVKELSAIEALSPTLLHLHALSQRLGLELAYNLYLTDPPHPLPPSPAVLPSTTTLSPYRPEVAQLVRESLPHPMPLRGGSSLEMGATDEEGHLGGHGGVGKGHGGGLAVIACGPANLISEASNSIAGLSIAERVRCGGIGFHGECYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6S0</accession>
    <name>A0A1E3K6S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035419.1">
        <property type="nucleotide sequence ID" value="XM_019172477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6S0"/>
    <dbReference type="GeneID" id="30189507"/>
    <dbReference type="OrthoDB" id="2576275at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="218" mass="23669" checksum="AFF4963EE987DF5C" modified="2017-01-18" version="1">MPSNSPYSAERFTVASGSPSQTQSPRDHRHPPPSPDKMVMNRGRGQYGPQLGARESTEHGERQREKEPMLPPVALTRPRTQEPMVPQDESSVPPAPPPTTAATAPTTPASGGEQIPLSKRLFHALVNKPKLSKTWEKKSFTDELRSAPAALGESTRRGRTGVEPGEGFASPRSRPTSLYASPADLASFRPLPLMMEERHHHSDSEVGDSARTAEGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K707</accession>
    <name>A0A1E3K707_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035499.1">
        <property type="nucleotide sequence ID" value="XM_019172557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K707"/>
    <dbReference type="GeneID" id="30189589"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="184" mass="19876" checksum="5ECAA3AD59E87472" modified="2017-01-18" version="1">MLHVWHDSVLSDAGKQTEYGLTTSFSSLNLTSEEPTIPISSFAAPLQLAVLVLAVRRHNLHQAGTPAEDPAWKNASVKPESLSAVSPSDLNHMSKLVLDMFALAKQRGVAASSAGRLQRAIRGRNDAESQLATKSTQLETTHSMLERAVVKMGQDGTTPEDIAVHIAMPLDQVKETLLRFGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K750</accession>
    <name>A0A1E3K750_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_00630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035746.1">
        <property type="nucleotide sequence ID" value="XM_019172804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K750"/>
    <dbReference type="GeneID" id="30189843"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000018">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="307"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO08891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="857" mass="94817" checksum="E01E6ADAB950D5AB" modified="2017-01-18" version="1">MAEAQPSQAPVFQDELTQDRTRQFIEFLDDESQPGYNYKESIRRMLDDEQVRLIIDLNHIRAYERTYADGLLLQPMQFVPALDAALNQLVESVHNPNKHKIEGKQYYAGMIGSFGQQHCNPRTLRSHQIGKMVSLEGIVTRCSLVRPKMLRSVHYAPQTQKFHSRSYNDSTIIQSSSTMTGTTTVIPKDDGDGHPLLMEYGLSTFRDYQNIGIQEMPERAPAGQLPRSVEVVLADDLVDCCKPGDRIQLVGVYKSAGGGAGARGFQTSIVANNVILLSSKQGGGIAQTPLTDTDIRNINTQSKSPKIFNLLSQSLAPSIYGHDYIKQAVLLLLLGGEEKNLDNGGHIRGDINVLMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKDTGERRLEAGAMVLADRGVVCIDEFDKMSEVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHRNIALPDSLLSRFDLLFVVTDDTDEQRDRMISEHVLRMHRYIQPGSEEGVPPIENLDQNLDVGGDQTESRTTETAVFEKFNPLLHSGVTTTSGRGANKKKVVMSIAFVKKYIQYAKSRIHPKLTKGAADWIVNVYSSLRNDDMAANQKRTSPLTARTLETLIRLSTAHAKARLSSRVDERDAIAAEEILRFALFKEVVRPERRKRRKINHQGQSVEVDSDEEEDENEVPEPAAAGQEDAELEAGVQRLNVTDSQRDRTREKNRRADGTQAERNEDEDEDFDMAEESLGLAQSPDPAPAPEPVELSAEQLDYFRATMSTIFESELDEDGSISLDALLPKVNEGKTDADRLSAGQVVDGLKKMNEKDELMFAEGDGTIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K786</accession>
    <name>A0A1E3K786_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035578.1">
        <property type="nucleotide sequence ID" value="XM_019172636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K786"/>
    <dbReference type="GeneID" id="30189669"/>
    <dbReference type="OrthoDB" id="2596783at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="292" mass="32937" checksum="5DB0493F2EC2C03B" modified="2017-01-18" version="1">MSSSPLNPFSHPPSVPDPQQSRHAPSSSPPANPMSSPTPFFRPSPGGQGSSSGPGLGKGKLSTRYTRPARKSLPSALASYSPAGPSNGDLFSEGTTPLEGAMWRERFTRRMGERTRRKQVKERNLEMRRGIGRPLFTDDIEEDEDELERKAKEDDDEIYRRITILQRKKAIHAQLVNEEYETGGSDPNLPDFWEDELEQMQREERDLIRRLEAGIPEGIEDEEEVPEELVREAEEIDMGEGRGMNMDAAVEEDEWDMDITWEEMEVARKVEEEAFGASGNLRRSDGDGMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7C7</accession>
    <name>A0A1E3K7C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035681.1">
        <property type="nucleotide sequence ID" value="XM_019172739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7C7"/>
    <dbReference type="GeneID" id="30189772"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="221"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="488" mass="53609" checksum="E2D075880D327097" modified="2017-01-18" version="1">MATDPQFLKYVDDHQQDYIRRLANAVAIPSRVCYSRNYTNSVSGNLSYVKDVEAMGEWLIQQLTSLGVKAEKRAIGTHELEGQTVDLPPVVIGQIGNDPKKKTLLVYGHYDVQPALLEDGWLYPPFELTPDPNGSGRLYGRGSTDDKGPVLGWLNVLEAHQAIGKELPVNLKMVFEGMEENGSINLDKFIESEKDKFFAGVDCMCISDNYWLDTKTPCLTYGLRGINYYEIKINGPDRDLHSGVFGGTVHEPMTDLIALMSRLVTPEGQIIVPGIKDLIAPVTDDERAKFEAIHFEMSDIHAAVGGDVTISDDTVATLMGRMRNPSLSLHGIEGAFSAPGSKTVIPCQVKGKFSIRLVPNLTVASVTDLVVKYVQDEFKKLGSKNKLDVYLTHGGEPWLADPNHYSYQAAHKATEAVYGQVPDYTREGGSIPVTLDFANILGLNVLLLPVGRGDDGAHSTNEKIDTDNYIRGTKLLGSYMYELAAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH45</accession>
    <name>A0A1E3HH45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027911.1">
        <property type="nucleotide sequence ID" value="XM_019180101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH45"/>
    <dbReference type="GeneID" id="30197341"/>
    <dbReference type="OrthoDB" id="10314960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="20766" checksum="B92ADFEADF8A46CD" modified="2017-01-18" version="1">MPSSSPHPKSLAVYWCSSDVYQTSLVDAQKFCVAKKIDFDDQFKKVPLDLFLTESEGSIQALKLWAHRVQDVCEKYAYRRNILPIALLFLAESYLDVSIVLCQEILSYHGEHGKLSPELYTLLDSVSSEGLVILDHLSRLEVARLKPRGNFDILDKKVNLAADAFRRMEERLVSLILQHRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLU2</accession>
    <name>A0A1E3HLU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027968.1">
        <property type="nucleotide sequence ID" value="XM_019180067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLU2"/>
    <dbReference type="GeneID" id="30197306"/>
    <dbReference type="OrthoDB" id="10338585at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="299" mass="33529" checksum="C9FF4306192883CD" modified="2017-01-18" version="1">MSNNNSKGWKDVNQDSFRFYDPSTNAFISSAPESVPAFLSASSLAYDTDMDNDLLWPEEQEGQQLGPEKVDAARQRVAPQATSWAEEVARVREAVGIDAQNPIIERQLSYLRSRPSRGVDWMRDASEWNRKVVSDYRDSRPSVNLTNVDVTQLRFWNDRARLAAWAISCGNLGISVPDTVMARMNESNADFNDSLSELNIEGFPNLRPNDLTEVMPIRAMIVSVDLNQGTLRDIQEGALEVVTEQQLEETRVANATIRRLYYQEGWADLNPEFQTLVGSWSESLEALRSAGITGLPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRS6</accession>
    <name>A0A1E3HRS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028092.1">
        <property type="nucleotide sequence ID" value="XM_019179916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRS6"/>
    <dbReference type="GeneID" id="30197149"/>
    <dbReference type="OrthoDB" id="2576574at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="907"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1007" mass="107912" checksum="E10E1780E13EE0CB" modified="2017-01-18" version="1">MSLDVAHPALTAARQAIADPADRTTWFLLQYNPAAPSPQAIPLAAGPLPVLPAWRRHLHETDQGVLFGYAQIADKGLVLLYLRPDVGGVKRARAIVHSRAIANMYPEYSCLITLADPAELTEELISERLGLGVPAPVEKARVEIPGGDGPNPLAPGLGRGIPPQKQRDATPMSAAAGSETGSPSRTNLSERRKPPPQLSALGLGTPSPPEPQAIALPSVEQLKEKEKDDRNRKPSFTSRLKHTFHRSSPSIEDTPTSSPSNTDKPTPLTPTSPSSPSMGMGSGRFKAASLGKVFSKKRAGTGEMESLRADGGGEPPRPISHDFSPALPPKDAPLSVSVPISQTSQTSQTSASPSPLAPSAAPSLHAAHGHSPYPAPSATPSATATPPGGGGPPLLGPPVPLVSRDSTKSESDAPSQSESQSQSRYHTPLGSPSPFEEEVVPNPRSTSLLTPLLTPGGGEAGLSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPSPFAFAFAFAFAFAFAFAFAFAFAFAFAFAFAFCSRDLSLSGKEKEKDQEEKEKEKEDDGRGEGQGGGRGQGEGKGGSDGYESSTRLAYDDPSTDTDTDTEDERVNPTPTRGAREREGEREGAVEGERVGVPSLDALPVSPVDDVPVPVPGGGGWGGGLGGDDPDHDPDPATSRGLIGRGAFPSPPPPPPPPGGQGLPEPEPGPGAETRETETGTRELEEGRQAGMAMAMMRDGMSALHTDTDTDTDTEREGEGEEGVVREAQAEAGAGAGAEDPAGRKVEWAEEKAREEEERERRREEGEERERERRREEEEEERRLAEEEKLSVLAEEEERRRLEVEEEERAKVEAAQAERQRLEEEERARLQVEQERKRVEEEALAAKKRAEEEAERQRMEGELAKKQAIKDGLLSGKRDGGVMLRGWVTAQTYKSMTWRRRHFQLLPTEMRLFKNESDAKPIQTIFFGPSTTISEAYEESQVKDSFKLISSLPEKGDEEFFLFTDSAEDKEVVLEGIRLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV36</accession>
    <name>A0A1E3HV36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_07841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028189.1">
        <property type="nucleotide sequence ID" value="XM_019179822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV36"/>
    <dbReference type="GeneID" id="30197052"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="36195" checksum="5BB4A1FD9A3657A5" modified="2017-01-18" version="1">MDSYGYGEPSSSNQPQTIDVPVGPTNQPKILLRNLNDSEATFHLSGTELAFANSLRRVVMADVPTIAIDQVLFLQNTTPLADEMIAHRLGLIPLISRGVEKGLRYTRDCDCDEGCYYCMVTLKLKVAFNGDGFMKITSDMLEVIPIIMDHRDNEMGIPIGKGNAAIPPILIAKMGKGQSIDLVCKAYKGIAKHHAKWSPLSTVAFEYDPYNKLRHTTHWFETDERGEWPLSNNAIFETPPEPNAPFDYNAVPSTFYFNVESVGSIPVRSVIEQGLDILVENLAGVILAVQKETGGDEEEGEGGEQGGIMEPNMQGMGGMNGHAEQGYGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I537</accession>
    <name>A0A1E3I537_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028342.1">
        <property type="nucleotide sequence ID" value="XM_019179654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I537"/>
    <dbReference type="GeneID" id="30196877"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="702"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="702"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="793" mass="85578" checksum="04C9FC681C11F326" modified="2017-01-18" version="1">MLSPIDTAAPAAPYNGLPSRTTTPTTPSMDQTPNTVDLRTPRPTTDHIGPEDIRDRDAERREQQESEGFGLGMGSGLGSASGSERSSLDMGPPLSTEKGNWKGKGKAVEADVLEHEDEDEAEFDPSLYQSYQSRLGEIAASERAGDGWSQRDELLQMANTLLPVATHQAPLLQEQIAAQQRTISDLQQQSKLSQQLIATERERHAVERKSWQTETQAIIAAKDAEASAKSGQRKVLDLDVGYHKELEAANKRLEMDNRLMAPRLVDTQRQIDRLVNELRLLRPHVILDSKPLHSTSTEVDVKPDISAKLAVPLPRYMPQLNTSRSARTTMGDARAEHLLLAARTIRTIRKRDTKIGRMTINELRKAGVSGPEGGLGYKEGYGEEALSETDDYSEGEDERRPSVSAKAKVKVQATPATGKIKRGVKRAAPGSSVPQTPSRPRGAAPTFPETTPGGSNFNDLLRAAEMATRPSSPAVTDPTILQSVSATRSTTRVCPDDDAERGSPKRRRGSAWGENEPHKGHAPSSSQGSASALDLLAQASQLDVAKTAPQSSPAQPIASSSRHPPRLTASSPMESSLGAPIDLTPRNGRPHLNQSSSMTDDSLDPSLQTPKGRMRGSSNASEYTPAKYLESGGPSSNNVLTTTPLSSVPPNPQAAAAAASEGGGGGPGAFASPTGRVVPGLGRYWHYTSEMPIKRVRSPYLKWTVEEDELLARAVAIHGEKWDLVSKGVPTRSYHQVRQRWLRKTGAFDKKNQSAPPSQLQNGVSYPNGTRYDPLPNEGAGASQKSASLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAS3</accession>
    <name>A0A1E3IAS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028528.1">
        <property type="nucleotide sequence ID" value="XM_019179490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAS3"/>
    <dbReference type="GeneID" id="30196707"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="55" mass="6035" checksum="72800262A3A87FDD" modified="2017-01-18" version="1">MTAPAFVNGRHAVPELNENEKKGVQKYEARAQAESQLAKQDSPFFSNTDKPGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB35</accession>
    <name>A0A1E3IB35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein light intermediate chain 1, cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028554.1">
        <property type="nucleotide sequence ID" value="XM_019179413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB35"/>
    <dbReference type="GeneID" id="30196623"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN85849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="579" mass="61530" checksum="E24BDD35F5D6ED62" modified="2017-01-18" version="1">MTAPGPSPGPSTPTLNLTNNNRTTSDDNTDGSLWTEILASTDRQQSLGRKNVVLLSERNHGRTHLLSQLTASSRKKKVPKPSQPHTQAAGEAGQERRSRKGLALGYEVIEVGEDEDSAPPLSVFYPPSSHASLLRLVPSALPAKSLSDTAVVIVLDWTKPQSMLQELLTWLSWVETWASEAGERGEVEELHERLQSHLQHYTEPSPANVGTTTYAGVGPLLPLGSGTLTLNASGIPIVVVCTKADLMDNAAEDVGVKGGGWEEKTDRAQQALRTVCLAYGAALFYTAPTQPTTYALLKSYLLHRLYTVPPPLNPPPTSPNTVSAPAIVGSTKFPFNHRANVLDRDAVMVPSGWDSWGKINVLRDGFDPALVEKGWKVSLSRYIAKSAGQEPEEDDGEPLEDFWQALLPSFASPPPPSPANLTTVTEPSQNFLSRQLDLLMKDPNRDPRQSFRHAASATSSSNVPSATNPGAGGFNNTAVGPMGGAAEGLSLPGVEKVMQEMEGRIGEGDDAEEGELKDKFARLGRKDGKAAPGTPAPAMPNEALHNFFQGLLANRGKTGGSAAGTPTKGASAEGAGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDC4</accession>
    <name>A0A1E3IDC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_07289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028777.1">
        <property type="nucleotide sequence ID" value="XM_019179296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDC4"/>
    <dbReference type="GeneID" id="30196500"/>
    <dbReference type="OrthoDB" id="2563735at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129722" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="58727" checksum="26EF44CDB39AE363" modified="2017-01-18" version="1">MSLLRLAPLALAVVPMVAADAAQFTFAWPGSPRLCDVVPLTWWGGEPPFQAWLIPTGGQPFIYDIPDSYYINGTGTYPILLQVSDGYAYTIMMSDANGIASGGTSEASIVQPMLSSPNSNTTLLSSQAPCLRNASENSTSLDFTFSVSGQVAQCATGLEVEWTGGKEMEPYNISVIPMDQGFSPWEIVMEKGTSWANRFLVNMTAGSRFTLMMNSKLGYGRGGVADIYEVTPSSSKSVNTTSCITQPSLPTGSWPAAATILSPLPSASRPPSPSNSSSSASYSNWGSPAEKKGKLAALSIGVTLLIALLAWGIWWLLMRRRRGSRMRVREKEGLESHFLTTTTASSSIVSPFSPSPSSATTPATNLYSLDLASSSGESVLASNTPSAGIRKLDTGRGSSLIGARDRSSSPASLRRTTSLHTLSDSQQMAEVQTEGGEEEEEKHQSYLPTPTPALRLSNPDTYGDVEADPQSHSLSTIPSSPHSSNRRRPLRPLRPERTYRRHADAGRLPDPADGRVGEGVVVDLPPLYSDVPRDRDGDGDGTRLGGGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFP2</accession>
    <name>A0A1E3IFP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028744.1">
        <property type="nucleotide sequence ID" value="XM_019179263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFP2"/>
    <dbReference type="GeneID" id="30196466"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN86561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="41339" checksum="B1625ABC39022F32" modified="2017-01-18" version="1">MSPPLDLTPVDKLEFLILVDNCQSLFSTLPPEFTHELPQHLASPRNPIDPLTGLPMIDLDNYCCGAHGLSVLMKTTVGDEENQVLLDSGPEPSSIARNISAMSVDLTSLDALVLSHWHRDHSGGITQVLNLRQDQLHTQGRNPEHDKLKVDLHPDRPIRRGIARFPATEPHCVLPPDPTFQEVEGSGGKVDPHSDPHEVLGRDGRKTGVGVSGEIRRIVDFEKGVRGGVRWEEDGDGKGEWFSDTMIMDERYIVIDVKGKGLVVFSSCSHAGICNVITSLLPLDRPIYAIIGGLHLVPTNIQPAAQTVDFIAHKIKPEVQYVLPLHCTGLEARGWLREEMGDRCVPAGVGMKGVFEGGSDEGYETAIGREMGFRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHL4</accession>
    <name>A0A1E3IHL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029158.1">
        <property type="nucleotide sequence ID" value="XM_019178881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHL4"/>
    <dbReference type="GeneID" id="30196061"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129763" evidence="10">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="185"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="535" mass="54736" checksum="808A660A9C5694CC" modified="2017-01-18" version="1">MYSTLKAATLFALLTGLAVQAAPAPQSGTSVTCDSDTQWHDDYQTQTCPTGTVCQADAGGNPCVWPSSGAATGVTSAAAATSAEDVGASASVAGGASSSAVVGGASSSAVVGGASSVAGGASSAGGQATSAGAASSTVAGSSGAAGSSASGVSGSSASGGSATSSAAASSGTASTTTNSTSSSGTRYVLYWDNYANMGGVEASQLTGATHVILCTIPFADMTSWATKVDSAAMAFQSSSDGNFDPSTASTLKGMVSGLKVTGALGGWGLDTPMATAVQGGESTIETLVDNAVAFAKAFDLDGIDIDWEFPAASDVPNLVTFLTKLKAGLPDDSIISVALGARIDTTDAAAYTSDTFSQLKDLVDMWNVMTYDYVNRYSDKTEQQGGGRVVETVMDYYEKQGIEMEKVNIGFAMNAKYFTGVTDCTTDNPIGCTLPGKAYYEDSGKDNRKSGWLRFNSDLDSTLGTDGTTWMEKVRPQFEKRPTDGSTEIADDVSQAWYDEDNQTFWTWLEPSDMSSVCSTWKSKVGGMMVWSANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHM2</accession>
    <name>A0A1E3IHM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029160.1">
        <property type="nucleotide sequence ID" value="XM_019178883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHM2"/>
    <dbReference type="GeneID" id="30196063"/>
    <dbReference type="OrthoDB" id="2596590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="704" mass="73141" checksum="BBE4D9A31FF75921" modified="2017-01-18" version="1">MSQDALMDAPGDPGHHTESPNPTQNSPDVPSTQQQRFATSINAFGLHPPAASSPALANALLSSREGYFGLTDQAVRKVRRPSMLSLTQNASFQSDGTPSEGAGPRSPLVGTSKQSSGMAEDKPGQAGEGRMVMDMVQDPSSSNAVNQFSSATSPNGPLQPTPRWPSVGSFQDSFLKRSTSTSTIPIDGLKTSTPPAPLDPSDAQRRQIGQDTEMAGTSPNGEGLKWSPSTHTETPNNHKGKGRESPTSPNSSKLHQPPFTGRPLPSALLQTLISESAPLEHEIQSEARLQRLLISHPAKLPLTPRAPRGSRGRFPEQVGGDDDDPDATFPDTSSLSALSRRWARDDSDSDSDDEHDETVGGEVNAAFAAGMDMDRPGSSSSAGWQTVLDRREREGSGKSTTTSGNDHRSSTGSAGQAGFPFPPNVQQVFSTPAPNSGQQQPGTLKNTRLNMPNSAGGVGPSPGTGYTLPNAFGGMGMGTPLGSPTVERGELAGSPNASMSSPGLMQYRESGSTGMRMGKRKAQEDRFDPYKRPRGTSPSANLLSSSPFPLSPSRQSSIPIPASPSHLPIYPSSLGSITPLGSTLGNGRGQHPSASRPGHPYARTIASRSRAASPALSIGSGAGSLGSGRGFLGQGGSTNGNGNGNGNGNGHQGQGSLGGLGLLSLANRVREEEEENVDPGPGPKPHTGDGEGEGVKESDRMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3II53</accession>
    <name>A0A1E3II53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cu-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_07035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028971.1">
        <property type="nucleotide sequence ID" value="XM_019179053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3II53"/>
    <dbReference type="GeneID" id="30196246"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129768" evidence="7">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="72"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="200"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="476"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="642" mass="69244" checksum="C7FB97D05E09F9FA" modified="2017-01-18" version="1">MRHSLLALFTPFPLAPLARVLTATPNHLPSPDPYLSARGSDVAVVDPSVFVPLANNFEITADTVTREYTFDITNAKASPDGFTRDMYAINGILPGPLIEGNQGDTVVVHVNNYLDQGQGIHWHGLRQNGTGHMDGVPGITQCPIPANGGSYTYQFTLDKQAGTYWYHSHFGNTMADGLGGPIVIHSPDEGVQAGGDYDEERIVWVTEWMHDDSETIIEGLKSSKGYRGSTASPQGDAVLVNGVGQTHCTNTDDPSCFSPSPPEIQVPTNSRIRVRFISAAAHAMFRMSLDTHELTVVESDGTPVWGPTVHEVPLAPGERYSVIIDTNGKTEGDSVWLRATTALACMPGGKDQVGLAVLRYGSGSTGNEAVGGLPNTTAWGDLSAAQAPCRGLDQYERLSPRENIGADNNALTSQFLNSERGTFLDHDGNMFDGQGFNNISYQNQINDPLLSILQSGGSCNTSLVANATFPHIGPGNIIINNLDSGIGHPYHVHGNESQILARGEGKLTAEDVDDGKVGLGLDNPVRKDTLWIPGGQWALLRIITDNPGVHAVHCHIGWHLAEGKLAVVIVQPDAIKNKNFPSAWYNLCDGTNPDEFGPSRRTLSAPTTEPRSLFTPFTKIRNNLSLDGLKRRMILLRGEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIL3</accession>
    <name>A0A1E3IIL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029242.1">
        <property type="nucleotide sequence ID" value="XM_019178759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIL3"/>
    <dbReference type="GeneID" id="30195916"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="246"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110093" checksum="6E473F4C84FA243A" modified="2017-01-18" version="1">MIRPRHLPLRSLARTPLERPTYRPAPLARRLLSTSNTPNTPRSTGSFYISNVFPIKFGRFDPRPALASLEQETLLDQLHAIASGVDAHGFTVESFEVSWKDGGVFMHYSYVPPTEDVTPTADAEAAEEKVARLGVEPGLASWTKNLPGRLFIPHLEESAKAHGGWPSWLGKYWASKQWSDRNREVPGHTLYSAVEEDVDGTVEEGGGLRKGSVGGVRGLQAAAGGGRVWVVKGKQWTEDMNRFASNRLRVEFEGPDVSQEMLYTLFRPYGRLADITPPSPVPSGSLRYAVVSYSGLTPAAIAINSLHGYSTATNSADFSLRVSSARTQGEGEEKKPIPMSRLRLYYERPLKAHAMRDWVSSHPRLVLPVVAFLIGTLSYTFFDPIREFFVRSKLEGVWDIEKYSLIKTLRSKFSLPTSFSSSSSSSDSSDEEGLGRNAWKDRVEAEKGVESWLAEYPSTFIAITGPPGSGKGSLVQRVLKQQDKPAMVIDCEAIAKAKNDAGLVSALAEQTGYYPVFSFMSSISGLIDLAAVGLIGQKAGFSTPTDQQLRQILETVGSALKDVTAHALKSHADDVQYQKSNLELEKLKDKRREMIRRGWHDGRLDCVAGNGLSELGGGEEPFWEDDMDQTVAVTTESLGTIPSQPIMPQPASETQQSNELDPESDAIKSLPIIVLKNFAQKTAKGDLWNVLAEWGASLVENKIAHVIVVTEGPTATKALTKSLPAKPLNLVGLADADETNALAYVSEKLRHHSSSARSSLSDDKSVNTLSAEDSAQIAKLGGRMVDLETLVYKVRSAGLKIQDAVDDIILRNVVELRKAAFGDDSVDAKGLAWTRAQAWKVVNELAKKGEIPYANLLQEFPFKGSEQSLKALEEHELVSVSYVDGRASMVKPGKPVFRYAFQALVNDPVFKASSQIEYNTAVIAKSESDIQKYEQELQQLKNITSDGGSEALGISSGWLSLGLGGNRAIRDRGRWLLDKMGDLVDKVGNLERENKECVKVLKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ00</accession>
    <name>A0A1E3IJ00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029024.1">
        <property type="nucleotide sequence ID" value="XM_019178930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ00"/>
    <dbReference type="GeneID" id="30196116"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129789" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="134"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="683" mass="74409" checksum="D6613EE358DB566E" modified="2017-01-18" version="1">MTTPNSHIAIVGAGIFGLTLSLNLKQRGYKHVTVFDEQYHEEEDEYNVHGDRDVDAAYRYSRKTTHETLNGSSLPLWKQWNTQIASTPAHLLPPGLNPSDRLFSPCGFLSVSGGLTLSAKDRVTVDAHKAAGGRGTIYVIRDPIDMARLRTSTSLNPSSSHWIQKAQLFDHPHPDPIHPLTNGFLNISSGSTNAPKTKLWLRHLCSQAGVNFISGGSRGKVEEVLCWEGVRRSRRGSREGEGKTKKVRAVKTGDGKVHEADFVILACGGCTPSLVPEVDELVERTMGSEVIIQLPTDRPDLWDKFSSERFYGSPRKEDGTITFGYRNSPKPTKPPLSQSPLTTKSSFPIPLPLSSPNTLSNPIPTSSRPQTARNHSKPLPTSLPIPTLLIIRNAISQIFPELRGVDVNVVDTRMGSYTDLVRPGSSARGGAGGGKVADWAPGYDGLFVVFGQDEQGAGGFVPDLGKDLFESLEKRANPFPWPSDSLPIRTPTPLALPTPNPLPSPVSYSYPSTGYQDHQRHNSLTGADPYAYSHGLPSFTGYPDHSTGLLSHHTLTDVHTAAEHKGVFPPFSPVSALRHSAEPPPPSYSHPAQGRGHDVGGGEHFNPSPSQQQAQQGYEDFENFEALGGLEGLAMVAAGGELKREREREEEREKRERERDDWVWAKVEAAAGLASAMVNGRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJP0</accession>
    <name>A0A1E3IJP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029375.1">
        <property type="nucleotide sequence ID" value="XM_019178674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJP0"/>
    <dbReference type="GeneID" id="30195831"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="171" mass="20377" checksum="2621A48EF3D8E3A9" modified="2017-01-18" version="1">MVNEDHPPQQSQSPSQKPKPLDDAILEEFYKYVNALVPTEIPKDKRLEKWTKVRVGDLLEVGFLDEFVFQGQRTPYRELMESAHSERIDEECAHETEFSKVLFPELRRPETFSRTDLPKRNQVDLARGRMNTYCFQHQHWKLDRTLDRFLISMSPWKSSKHRWERTGSDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKM4</accession>
    <name>A0A1E3IKM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rrn7/TAF1B N-terminal cyclin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029439.1">
        <property type="nucleotide sequence ID" value="XM_019178532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKM4"/>
    <dbReference type="GeneID" id="30195685"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="86"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="758" mass="85632" checksum="E013C58544368B9D" modified="2017-01-18" version="1">MARKCPLCGSRKWKRDRVTGNAVCEDGHVLQDYRSELLVIDGGVNFQLQRRRTAKGPRTNKQRTEGRKNKELYHGNEAEYMKIQGLQLLIRHQSYTLSKLWQLPEAFEMIVRDLWAYQLSISVLPDIPAPPVAEEETPIQHSKSLPKLRIDPDPQPDTRDEHSSSDSQSDSDEGESEPDDNIDPELLRDLEEGDGDGEDVEDGAKEDKNTRGDARWKRKRRLRAADTITTLVLALWMMRVPVMGSDIESLVNSVQIPYVDFGHSTYIPENMKKRLNRSAVQALSPRRSPSPSKIHDSCRIFARILYRKYGVHVPLFNFHPVSWSIASSLGGTQAHLCPAMMHALLLRLMDLISVPFHLTTHDLSTITRKPRAQSSYKSRSKAKPKTKKKPRPTADDEDGDSNQEDAPRDEQEEGPRWEKYERTKRMYDELPPELSIVSAWVLLMKLVYGLDGRPRAALLSRDPAIGLPKGEIWLRELDRRLGEGILSARKKAPRISQAYFVSMEDADINSFLDNAEHILLDHHAPGSDATHFPLPPSSPVLKPNKKSWTAFHSDLTPVVHTRPPLAQSSQTLPLMPGEKTRSYDTKDAFGLYPREMEVVLKSAGEAVGFDWKEVGKVVKHWERKLEKVKGERRKAGRSLVSGYHRTKHRPSKRPSRPRTGSSRQPTSRDPSRARSKKRTGSTSVLASREDSRARPRTRASSRAESESFGESSEPSRVRGSVPGTPVLSRAGSRSRQSTGSPRTARRFAERSGDSSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKT4</accession>
    <name>A0A1E3IKT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcofluor white hypersensitive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029492.1">
        <property type="nucleotide sequence ID" value="XM_019178585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKT4"/>
    <dbReference type="GeneID" id="30195742"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000100">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="301"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="494"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="716"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114869" checksum="056CEE8BEB3D6A9C" modified="2017-01-18" version="1">MTVLLEFPAKWVTHAHTFTAALAFATALFLGWAAGLWKKLCANSVARWPVEWFPSVSATIGDHVPTRAPFQILIALCATPRFLLLIVQWLVHRNPSLKSRPSGARRPNTALADVEFIVGIVRTICCGGWVYVTSRDQPDVHDFFMILYLLLTVPWMYLSASNCSSAATASRRRLPMYGYLCTIPPLMWMYYRHSSLKIKGAYTYYSILEWTLVFWDLAFDSLSTLELGHLQIAFVDSSSPSTDNLSSCQRTTTFTFAKQPSELKPSADEPLVDWTNHGNGRPSSSLRLGLAWISDVYFGICFWTVFTGLSFQLFYWSVWKLALAGSELALMGNLAGYLFHSKSAFRYLVSRDAQITHRSITIFFGMGCYFLPWPFARLVCLVVGTWAGWSALLGTWVRVQGSEEILAEGQTLGLGIAITMLLKYVNYSNNPFWSLLNGSSGGWNKTGLVLGAISLAEYIYRPLDLHPAPPLPEAPGKDKGQARSAPPTALQTRFMSLGLGTAIHLIQTFLMDAGTVISWTWTGYPIKGPTLHPQAGFIIAATALGLASIPNALHPAWSTIGCLGALALYAFPDWTGFYGGVVLTYYLSSILPPYVRAASACSPATTFGNALLAYIVFDVVSVVTAAYAFVPMGWLLRERTDVVLGACMLSTAAGAWAGYSLDLPSGSSLPRRTHRRTKAVQRFTLISAGLFSLLSILYSFSRIPVQAPAPYYPEHRIFSAGIWTVHFGVDKDGRDSQRRMRDLVQGMEVDVLGLLETDLHRFVYGNRDLTRVMAEELGYYVDLGPGPNKHTWGAVLLSKFPILNSTHHLLPSPDGELAPAIYATLDIHGEHVNVMVSHNGQEEDLRDRTLQTTELARLLRETADKPTVFIGYLVTRTGDRRPWPYQILMEDGRMWDIEIDDRWRWCEYMAFRNMWRVAYARVHESDISDTELQVGKFMLGKPGQKVIYEDNQQLYWHVGEGDIPEPWRLPSQFRGNGVRGHRYVVWDGPLYYLPPKHSELRGYGWDWSTALDKTATIERIGGVIIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA0</accession>
    <name>A0A1E3IMA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-binding cassette transporter YOR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029636.1">
        <property type="nucleotide sequence ID" value="XM_019178480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195633"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="913"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="224"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="547"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="875"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="789"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN89727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1446" mass="160309" checksum="13D2E0A4AA8BD72D" modified="2017-01-18" version="1">MSRKDSPSTPAAVGQVAEGKVGDGKLDGSKDGSVDIPATRATGYRDLSDSEVAQFPGVKREHWWELWRPRHTPPPPKVSLEDADIIPLATASILSKLTFRWVTPIMVKGYQRPLQATDLWKVSISHAASQPLSTRFMECLEIRQKKAREWNESLPTATPTRKQRVKWAFTAATRRRLASEYARHGSDSTYNERMATLEKEWRECSGKRHGSVTWALNDTLSGFWAGGLFKVFGDTSQIMIPLLVKSLINFSKEVYAAHQSGEQEPNIGRGVGMAIGLFLLTVMQSICQHQFFFRSMATGVLARGVLIAGVYKKSINLSVEGRTAHPNGRLLSYMSSDISRVDFCAQCESHQYAVWTAPIQLILTLILLIIQIGPSALVGFSLFVILAPLQTWFMKFSFKIRKKSMVWTDSRSRLLRELLSSMEIIKVFTYEIPFLKRLKDFRKKEMAGVRKILMIRAANQALAFSVPSLASVLAFVTYAASHDNMDPALIFTSLAFFNLLRQPLMFLPRALSSLTDAQNAMERLTEVFEASDRAESTVIDPSIGMAIRTRDVSFSWSKLNAADAKEEKEKNFDAPFGISSLSIEIPWGKIVAIVGPVGSGKSSILQGLIGEMPQLGGSVTFGGRLAYCQQSAWIQNATLRDNITFGQPWDEKRYWQVVRDACLVPDLEILGDGDLTEIGEKGINLSGGQKQRVNIARAFWSDAIIQLFDDPLSAVDAHVGKSLFENAILPLREKGKTVVLVTHALHLLPQVDHIYAIRQGTIVEQGTYTELIACRGLVEKLMTEFGGLGGAEEEERAAEEETALDEEKSESTKRKPGQVQEASDGLKEAGKGKAAGTGKLEGRLMVSEVRKTGSVGGKVYKEYLKAGKAKYTVPLTILFAIIMQGSQVMSTVWLTWWENSTFHQAWSTYQGVYAVLGISSSIFIFAMGATMGIIANLASKKLHSQALENVFYCPKSVFDTQPLGRVLGVFGKDFDTIDNQLVDSWRMMAMTLVTLMGSIIIITVYLHYFIIIIFGVGIGYWYFAMYYRTSSRELKRLDSMLRSLLYSHFSESLSGIATIRAYSETPRFIKDNTYYVDLENRAYLLTATNQRWLSVRLDFLGALLVFAVAIMCARGGGGITASEIALCLTYLTSVTQVLGMVTRQSAEVENNMNAVERVLWYSNANELPQEAAHHLPSTDPPMTWPGQGAVEFKDVVMSYRPGLPPVLKGLSLSISAGEKVGIIGRTGAGKTSITMALFRLVELTSGSISIDSHPIDSIGLSTLRSRIAIIPQDPVLFSGTVRSNLDPFMEKEDVVLWDALKRAKLVGQGGRGKEEKTFGLDSVIEEEGSNLSVGERSLLSLARALVKDSKIVILDEATAAVDLETDAKIQSTIHREFSDKTLLCIAHRLRTIISWDRILVMNAGQIEEFDTPLSLYDREDGHFRALCDKSNISREEISKARQSEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMA2</accession>
    <name>A0A1E3IMA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029639.1">
        <property type="nucleotide sequence ID" value="XM_019178483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMA2"/>
    <dbReference type="GeneID" id="30195636"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129835" evidence="1">
        <location>
            <begin position="20"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="512" mass="56790" checksum="5EA1699697A2CFF0" modified="2017-01-18" version="1">MTLALVVFRLLLSAMVVMAASIPNVGKRYISDVLSEGYRNLFDDSMKILDNNFALPFLWKSPKLSSWYAVGLLARNEGDDVEIANKLIHNIVTKQYTDPSFVAYGTFLGDYHGPYADGESLWEPKIYGSYDPNNALFVTIAGIIIDHDFASLLEPEVLANLRKAMYMAVVGDGYRVGGESGDNLYPGYSNPWYMRCVSAAYLGHMYDDANMTYWAENWAQEAVDLFNQYNTLAEFNSATYEGVTLFALSLAQYAPDNSTIYKEAPRLLEAIWDQISETYNPSLNTLSGPWDRTYGFDMTQYYSVLGSAITGITGKQKSDPMPNPLDGANHYTDMAMMPMQAYTSPYIMSHISSSAKSRFSSLYAPHSYTAQSISPPWDKRARNYTFWLEKGLSVGGMTFDEKEVGGPSLNQPSFSPGVIMWDAGKTGTGAGWISYYPTNPACEILASSTNLTIRYPPTQDWPNGTTSSSIQLLIADPRINEALSNILEGSDEKDIGFGKEASAYISAVYQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS0</accession>
    <name>A0A1E3INS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029775.1">
        <property type="nucleotide sequence ID" value="XM_019178337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS0"/>
    <dbReference type="GeneID" id="30195483"/>
    <dbReference type="OrthoDB" id="2577913at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="246" mass="26707" checksum="70168184512C341A" modified="2017-01-18" version="1">MRLTPPYSVDEAIGATWTSIVHDGKQESPIHVYQGEMERFTSWAQPGSVRRVLRYDSDPPSPRDQPPSVHGTVESEPVNREFVVEGRLIKCFISRLENPLPSLCASLSTPPPSIVCSVPVRRCYGVEEEQRNGRFGGLGGHRLAYKSTVLLGYADEGMSMLLRSWFRDMENEQVAPPATSQPTLGAAASNPLLVASSGLIGAALGEEDMRFSSNEAELAHELPPVAVDLSGTNALSPHDGIIPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INT5</accession>
    <name>A0A1E3INT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029789.1">
        <property type="nucleotide sequence ID" value="XM_019178351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INT5"/>
    <dbReference type="GeneID" id="30195497"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="154" mass="17474" checksum="38BB6846BAB304DF" modified="2017-01-18" version="1">MGTVFSLFKRSASAAMGAPKYVYKIVPHSSVDPRFTFPVPIPTSHQFILPLDLQDRFIHLSSAAQIPKTLGLFFKEAESVVLLRVETERIGAWKKLEWVMEDQEKRTGDMPYLCAHAWPVPLEGEYVESFKEVHRKGGDWDAALAQGELKSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ76</accession>
    <name>A0A1E3IQ76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029859.1">
        <property type="nucleotide sequence ID" value="XM_019178140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ76"/>
    <dbReference type="GeneID" id="30195285"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="54173" checksum="8003AFD0D6A069B5" modified="2017-01-18" version="1">MGDPPPQSSPVAEGPPGPFSRLSENAPTPLIHPEPEPEPSQTLDIDPANVGSAGAPGTPDTGEEDSKPIEAENAPQIPPASGAIDNDVEMHDASEEPSSSGHADFTPGPSTAASSPSKMEAVDLAMSQSNGSSHSGANKKSLTNGLKSATSSAPSSKKGKGKTKVDELKGTRDGIPDSRSATPPTPTTPTQYTSPSGAPVDGRAVYCICRRPYDEEEDEGLMVGCESCDGWYHAECVGLDEDKVDLLDVYICKSCERSTAQRTMYKQACKRDGCYKSVAGSNSKFCSARCAYRYSQAALGAVTSKQSLKQLTKGLANFPSPNLGVSIIHHIPPTTPDVSQSPYDDVQFQLSMIQSQLESTLKAINIIQKRQAVLSAAIEKCDNLTPIVFDDGAPPKKSKKKGGGPAPPKEDKPCGWVVVLIAEDEEVDQGVKGHGAGIVVEGAEEWQVCMLPRRKCDRHQGWQKTIASRTQNSLLECQRSIEEALETQRISTEARDSFVAKRDSVKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQM5</accession>
    <name>A0A1E3IQM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029758.1">
        <property type="nucleotide sequence ID" value="XM_019178320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQM5"/>
    <dbReference type="GeneID" id="30195466"/>
    <dbReference type="OrthoDB" id="10488477at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="195" mass="21460" checksum="C4832FB73DD0DD6A" modified="2017-01-18" version="1">MASSQVTSQVWPVSNDDNCDDEACFSIGGILEKGGTQSPSQAGEEQTEKEKKAHIWSCTFIEPDGEHIYRGSFTTCSRASKSSKAENADYITRANELSMALYDSIRMTKSLWGPACRTSGNVDHLIEAEESTFHKLVEDMPERYGDIAWHEADRNNAVRTVMLYDEDSSQGTSSMGDGSDVEEVVAGMRLVLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQU8</accession>
    <name>A0A1E3IQU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029917.1">
        <property type="nucleotide sequence ID" value="XM_019178198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQU8"/>
    <dbReference type="GeneID" id="30195344"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52598" checksum="A22528F40B83D11F" modified="2017-01-18" version="1">MSSPPTSLSDPIAYLALLKFHRLLPRCPRTNLPVSYADLGDPGGVVVVYLLPSGCSRWVAAPMDPVAIKYGIRLIVVDRPGTGGTGQVPLNERIARSCEMVVSVLEHLDVKPAHMLATSAGIYYALHLLINHPSTFQTSLNPPPKLWLIAPWVPLLPSDDPDYWPFKWDWIPTPLIATQHITTPHLIKAAEQAQKVYNQGAKAYDTGKAFALRWYKSYFDPPASSSSSSSSLNQGSGVSSPVPSRSSKGYAAEGKGGEQDLGGDTQKLLNGIRGAGMGEGTEVRAPDPTEEGEGEGEEHDYDSGEWPPRERFWGKTPCCITCTISGYMQAENAQGIGQEHLICLNRGLQNTGAPYLLTALSDLAATIEFAQSPVESEARTRLGKKFGMSVGERLRDSETGGGGGGGVKWPLEVNVWWGWLDDMVPRKGQLWFNDLVGQYGDAIKLSIHDVPGGDHADLLARQEGIHQCFQLIQFQGNSTAPTLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISC2</accession>
    <name>A0A1E3ISC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029981.1">
        <property type="nucleotide sequence ID" value="XM_019177942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISC2"/>
    <dbReference type="GeneID" id="30195078"/>
    <dbReference type="OrthoDB" id="2577721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="95" mass="10723" checksum="13D1136A82AA324A" modified="2017-01-18" version="1">MPSISNSHLPHLRLLAAIRKAADLHLGDKVGQILLSQVETDDLALIKHAMRAKFPILFADGSRFVREWPIESLLKQRLENSKKEARRKAQETTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITR0</accession>
    <name>A0A1E3ITR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030131.1">
        <property type="nucleotide sequence ID" value="XM_019177747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITR0"/>
    <dbReference type="GeneID" id="30194881"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="83" mass="9037" checksum="D733FE0EC4FB16B8" modified="2017-01-18" version="1">MPADTPAQPKTQQDTPDPNPTPSADQQTSPEDHKTDLPPTSPSRQEPADQQEAEVRPYPVPPSAICPTASWPPSVLHLYQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU66</accession>
    <name>A0A1E3IU66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Kinesin family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030232.1">
        <property type="nucleotide sequence ID" value="XM_019177848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU66"/>
    <dbReference type="GeneID" id="30194982"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="86"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1116"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1137"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN92098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1193" mass="128699" checksum="A286F62BB7DCAFE9" modified="2017-01-18" version="1">MSRRPTTSRAGISRTASSASIAMPPPSRVPNRPPSAMSISQASQRGEDAEGRPTSPSRRARKVTGGSISSKKGDQGLHLNENGEINIQVVVRCRRGRSTQEVTQASPIIATTGGPLSKQVTVETTPQISSTMSSFTTASTYGGSHQPSTKTYPFDKVFGPEADQTMVFDEVAENMLAEVLAGYNCTIFAYGQTGTGKTYTMQGDLELTNLGAPKSTAGIVPRVLHRLFNILEADTESEYSVKCSYVELYNEELRDLLAPEYKGEQGGNAGLKLYEDGKKGVNIQGLEEAGARTLKEALGIVDKGVKRRQTAETKMNTESSRSHTILTVTVHVKESSMQRGGEDMLRIGKFNLVDLAGSEAIGRSGATDKRAREAGMINQSLLTLGRVISALVEKGSHIPYRESKLTRLLQDSLGGKTKTTIVATISPTRSNMEETLSTLDYAIRAKSIRNRPEVNAHMTKAGLLKEYVGDIEKLKAELTATREKNGIYIPEDQWRELQAVQHRQKSDFDEARERAGAIEVALKTAKKEFDEISVKLITTSDELAQVREVERTLNEMLDETKLVLGQMKVKLDEEEAVSQAYMQGEDRLDAVAGSLKQVATESVNDVGSLFEKIARKAKVLGSNADAATAFGGQMQGLSQGLNAGLAQLLNAHSAFGDSVRSEMSALALTGQQATQHDLAHLDKSFAAFTDLAQKLSASNEKGQRESADMSKSLLAVKDEVQSSVREWAQGVSERSKSMVDELLEHQQLHLTAVGSVLASTSDLVEAIIATSQQHLATEAAAALRARELAVQRSTSEAERLRSQNNLLMTLLANEKSKTAKLRTELVGNLTSMIEDFTDAQDKGWSEAVEKAKRENQAGIVSLEEFGDEVGEAWTEGEERRKVFETEATTGREAGARQKELGQQALGQVREGLRQRLIDYGRETMGEAEKHVQVVDGFCVKLTKGASNVASKTSARGKKNSELVEAMTKNASSTHEASKARSTAMAGSIEALTSTLLASQSNASATFAQNHSSAESSLQAIMSSAATFLQSGIEEDVPTGITPRKKTWNVQSSWGRTGPREAILADWRRRQGIPEAEFGTSGHAEESSIGTDDTVKGDIGQLSCSSQPISREGSIVFPSQTSSREPTPSSIPPPHFLNASTRQASGQTVPKTKALRLPAGKKLSCDGADEPRPVVAVLGEGGVNLPRRAGRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU96</accession>
    <name>A0A1E3IU96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030276.1">
        <property type="nucleotide sequence ID" value="XM_019177892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU96"/>
    <dbReference type="GeneID" id="30195027"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="93"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="357" mass="38919" checksum="F0DDDD274A666CF2" modified="2017-01-18" version="1">MAQNQNHHHRKYTHHPHASDSQPPYWALALRAKGLRNAAVIGFQMHHYASPAAPSPTRTKWIDAILGDKQGKNTIRLDIYEPKEAKTGRPGMIVFHGGGFVLGHGTDDARWAAAANETLGAVVIAVSYRCAPENPFPVPVEDCASSIVHLAQNAKAYGVDPTKLFLSGFSAGGNLAFSSYLLLRSAAKWGYDLPCDPPSVQGIIVFYPLLDYSKSRPEKRDACANPEFTLAPSLTTLFDSSYLPPGIDLVDPRLSPGLVSDELLDTLPAVHMTLCEYDMLLAEGLDFQKRLEERGKDVSVRQVPGEKHAWDKPMPLYPKPSVKVEYDAALDVIKGYLSGNGSTKAQESTNGSDGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVN6</accession>
    <name>A0A1E3IVN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030307.1">
        <property type="nucleotide sequence ID" value="XM_019177556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVN6"/>
    <dbReference type="GeneID" id="30194686"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110481" checksum="507C65720031756A" modified="2017-01-18" version="1">MSAANAIAGPSRPSHPYTAHSTPLLRRAESTFSLSSGTIASSRPSTPLIASHGPRIIRSGSVFSKEQWKKEEISRRRQESRDKLKSSWDVLFDKYKDVEDDDEVDLLTGRIVKDRGSLRSLLRPMHFGEDVDGEDEDSSVNGNHEFESDEDELGDWEGRSGLDSQLPEYESVVDSGPAWTTEDDEDFREFLRAEERRKTMYGDEEEEDPEDDAQPLAKGMNSAFADTERSPRSLGTRILATPTLADLFQSGSEDEFEADIRDTHDEASRKTPAPARVSSPIVPPKPVQVRRRPRMTVQVVIPCRPRSRSFISSSSNPPPAYPSIPKSASAPTLADLFTPPPMGNLSISKIDKGKQRMIGERPAEDVPDRSTSTTGFYWTTKIYMADGKPFTCKDCLRAGGDRRAKAGLCKGRTSDCKFASIDSGSVTDSASARQELSRPPVPRSAGGQRKRICRLCRDAGGERAEMAEQCLGKHSFRRCRYFDQYREDDTDGGESEGEAEKASRTPTLHSRERRTSTKPHSPRPQPESIERGPPSVIPSRSATEPVVIVISDDDEDVPTPKPTAPLPRRARSIAKRPTPVNLAAPPSPPLSSPLMAQGRASRMPSLPPSSPPHPDVFSPVRSTQRPTMSPSNSTSRSRLLDSSPMTTSYTRPSFSVSGGQVFQPTPPPSSTDGTRSQSLSSDVPTSSALKKSALRRPSESLLLGPGFSAKRTRFSLAPRSPPKYPGSSSTEPESGDESQDELDLLSSSDRSDDKFPVYESSSSPLRSEFSVRAADLGMRLGPEHTGRLPSTMIKSLVPSMSNYRSSSTLGSSSTGFTLPTPPPSSAGSNGSRSSPAPSATLKSGSVARNGNSAKRNENPKAGLMLPPPIPSHRLKSATPSSSPLKTTLSSTPLRASTLARPPASAPTAGAGIRFVSMSPAVPQARPRSRSQSVSIEPGRSQSRPATPTHPKTPRATRTSSIVPARLARTSPAKKSMIYKSLEKAVREVGDEDGLEWGLDEETDDGGRMWRDSSVSAYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVV3</accession>
    <name>A0A1E3IVV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030377.1">
        <property type="nucleotide sequence ID" value="XM_019177626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVV3"/>
    <dbReference type="GeneID" id="30194757"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="72"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN92750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="523" mass="58210" checksum="DEB9BB652C9BDEC8" modified="2017-01-18" version="1">MAKFDTIIKNGVVVTAGDISQVLSLSVLSPMANMDCRQYWIGIKDGKIKSLSETFDEEEMAGAEVIDAEGAYVMPGGVDCHVHLCQDLKTGGQCADDFNTGSLAALCGGTTTIVTFATQTRSDDDKSLLGVVEKYNARAEATGSYIDYGFHVIIVRDDPEVLEDEMPRLVEEWGVTSCKLFMTYESQRLKDRELLDVMVAARKNKVTTMIHAENGDMIEWLTDKLETKGMLAPYYHALSRPPLVEGEATNRAIAMSELVQNPILFVHIGSTLGMNNVRKAQTMGLPIYAETCPQYFNLTWDDLKRFHSPTCFENSKMICSPPPPPDDSDRELLFQGLHNGTFTIFSSDHCPFRYDSPHGKPSGILDHSASMAVEFIPNGIPGVETRLPLLFTGGLLEGRISPQKFVELTATNPAKLYGMYPQKGTLQPGSDADITIWHPQERFSPFQLRNEMLHHNVDYTPYEGQTFNNWPRYVLVRGQLSYAEGAVKGKLRDGRYLKRGPSQLSTGLPGKKDPRRVAGWLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW05</accession>
    <name>A0A1E3IW05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030369.1">
        <property type="nucleotide sequence ID" value="XM_019177618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW05"/>
    <dbReference type="GeneID" id="30194749"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN92742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="18242" checksum="B6F5186FDC307E00" modified="2017-01-18" version="1">MINYVMLVSRQGKVRLAKWFQTLPPKTKNKIVKDVTQLVLARRTRMCNFLEYKDTKVIYRRYASLFFITSISPGDNELITLEIIHRYVEVLDRYFGNVCELDLIFNFQKAFAVLDELIIAGEIQESSKKTVLKIVAQSDAIEEGELLLTDLKDSGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW49</accession>
    <name>A0A1E3IW49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030446.1">
        <property type="nucleotide sequence ID" value="XM_019177695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW49"/>
    <dbReference type="GeneID" id="30194828"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000143">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="632" mass="70354" checksum="52B65525F3AAED6B" modified="2017-01-18" version="1">MSGDDPGPSSNYYRAFPATADGPLRPPEPPRSPILGATLPPHQPDRDYYALLNLPKDAPDSAIRDRYRSLATTWHPDRQRSDSARLAAHTQFTEIQRAYEVLIDPMKRTVYDMFGEEGLKTSWEVGPRVKTTEEMRKWFMGQAYEKKSLEAEVLVKPKSEMEVVLDARAVFLPRTYFQDPDQLKHDPISRALRVRPGRAVMKHSFEIPVSPNTQFVIEGQALSRNGRGGANILGTVKHQFSPKLWFEGGITCLNPRIFRAKGTYTIDEDQYLTANIVAPTVAAPPQLGFTYGRRLYQDTTGFMTFEPGSFSLGPWGASRTENELSPSSLSIGITNSTRSGSGWTVQTSASLASNQVSADYSIPIPGGLKMKIGAEAGLGQSVAGFVTAEGKLSENVRAGLVLQMEIAGGIILKLRFNRLGQKLSIPVLLAEKLDPKVLLGTTLLPAISYYAIYNYYLVPRKKQRLRERVRELREENKEFIRQKREEAIGAREVLEKSVATKVVQEKERNGLIILSATYGLASKIDNPIEALSEKPIVTEEDEEEETIDVTIPIQALVQDSRLYIPGGKGKFNVLGFYDPCIGENKKLKVQYSFRGRLHEVVVEDASPLRAPVRSKSIQPDVACVLRVLMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWL9</accession>
    <name>A0A1E3IWL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030452.1">
        <property type="nucleotide sequence ID" value="XM_019177701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWL9"/>
    <dbReference type="GeneID" id="30194834"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130063" evidence="1">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="242" mass="27645" checksum="66DF7D2E883B4381" modified="2017-01-18" version="1">MPFGLLTAIAACPAIIGTTEAIQQGQKTNAREQHRGKKVNLTVKLHGADMYREKFEGALVVLKDNKLWVEHSDCIELEGSHPFSGYYLPHPQHQSRWKGAGFKGEGLVTTTNAQNMLNWVYVDKDTYELKHGIRVQAQDHLTGPWDCTQIDRRMTFEGWEGFVVVQVDEERDLWGLFFDRDDNGLSGPGQIGEVKEGEKRKRMLQVELVRSEMEKTRYDAFEERRERLKALAIKQKQAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYH2</accession>
    <name>A0A1E3IYH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030580.1">
        <property type="nucleotide sequence ID" value="XM_019177427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYH2"/>
    <dbReference type="GeneID" id="30194553"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="213"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="40445" checksum="05079027A2458353" modified="2017-01-18" version="1">MSTAIPETMNAVVLKQPYKVALEKVPTPTLLKSDDVIVKVHLAGLCGMCILLRLLSKLLTMRMTGSDLHLYRGTEDAGKDYVMGHEVVGTIVRKGNDVKEYSIGDVVAVPFTISCGKCYYCKSSLTSRCTSAALFGTPNLPGCQAEYVRVPLASACLLLKPPQLPEELMLLMADILPTGYSAAYNAWKLLGWGEEKGGKGEKRGVCVVVGCGPVGLCAITSALTLFDKVFAVDPTSSRRELAAKHGAIPVSPSDLQSSVFSATEGRGADAVLEIVGNQSAIDTALSVVRPYGAVSSVGVHAKELKIDGGLLYDKNVKLQFGRCSVKHFYLAALELLVDNQKLFESFIAHTVNFDQAEKYYELFEQGKVPKTVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYJ2</accession>
    <name>A0A1E3IYJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">L198_05360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030600.1">
        <property type="nucleotide sequence ID" value="XM_019177447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYJ2"/>
    <dbReference type="GeneID" id="30194573"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="56365" checksum="D98415CA6B2081B1" modified="2017-01-18" version="1">MIGFSSFILRNYYSAIGWNEDNLYSSFTRSSSGESLVDFQIPQSLILQLTNAPTPVFFTSYALDALPQLNGSLSYITTSEALREIGPDRKLAFKDVVERFRVLPPPKRPQPKDEVWLGGKRMEGRDYLLYSRLHLPSLHLSGLATTRFGPTLQAHLAFLSQPGPPTPTRPTSPNTAPSHSRQPSEPSAPAAPPTPGNVFLSLQHDTGRYCGEYTYSAQDGMFGIRQLYNFGWHGEEEEDKVEKRVKDIREGKRIDEEDWMEGGLKGRFSAGGEVYFSAKQRSFGISTGLKFTTVPPTLPLPPNAPAPSPPTTLTLLYNPLIGFLSSAYSAQVSPTVALATRFGVNVYSYESDFSVGGEWWIGRRRGKRGAEHEDALARIAQAGDAVGPAVEENRELAQLMAKKAALKDTTLREEVIEDVVAEQQLDSPVPLVTDANARKVLGRAVPQTQTREPVDDERDGVLKARFSGNWQIALLYEARIRNCLVSAGINADLTGTQRPIKSVGLEVQYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B2</accession>
    <name>A0A1E3J0B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030506.1">
        <property type="nucleotide sequence ID" value="XM_019177353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B2"/>
    <dbReference type="GeneID" id="30194478"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN93401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="322" mass="34783" checksum="44584E6ADCF39D60" modified="2017-01-18" version="1">MQVRLRGPQGVSTLELDPESTVHHLRALVFAATHIPPPQQHIKYGYPPKPLPDNTPLLSSIPITNGEQFIVSAVPAAITSEPAPPMIPAPKIEGPDSVALPGRDAGYLQLRVVPDDNSCLFSATAVVFEGGIDAAQRLRTVVAEAIRADPETYSQVMLGMPRDEYIRRILKPETWGGAIELSIFAKQRVASTTSSAILIPSLATRLKLLHSMSLPVDATGLARTNTTLDYDAITLSPLPVSPPDFHTSVFPSVDQTILLTADNLVAQLRARHYYTDTSNFDLRCGVCKQGLKGEKGATEHAKKTGRECDSGQVAALLIADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0B7</accession>
    <name>A0A1E3J0B7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030783.1">
        <property type="nucleotide sequence ID" value="XM_019177202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0B7"/>
    <dbReference type="GeneID" id="30194321"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="246" mass="26479" checksum="3C8702037D002270" modified="2017-01-18" version="1">MGIFSNSVEDDLLVSAAFPETNAFGNVVNGEKNPLLIQLVNAGSKNYTLLGATSSFHDPNNHWSLIRNGTSLKYNVPLITGSNFSAPYHTYSEFRPQELGLTVSVKVSEAGSKDVQWITALNRTVGIVEAPGSWLDFQLIFLYLVIGAALALGGWWAYDAFLAPPVSKKKSGLGPKKVQAVVPGKDAAYPEVKPYEEEWIPEHVLKSKGSKLKQRNVEGTVSGGDVTSGGETSGGEVKGKKRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J184</accession>
    <name>A0A1E3J184_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030929.1">
        <property type="nucleotide sequence ID" value="XM_019176897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J184"/>
    <dbReference type="GeneID" id="30194004"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130061" evidence="9">
        <location>
            <begin position="24"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="798" mass="87795" checksum="9B1A47ACB5A96C9C" modified="2017-01-18" version="1">MRISSIVHFITALLTFAPLRALAADTLYTDAVTYCAEAKAVIVDEFGITYHRSNQSVTFSFSLASVESNLNVSANLYVNAFGIEVVNQTLEICDLLSGVACPLPQVNFSGYGTYPIPSRYTQDIPSIGFSVPNLEAYARVELLRVENGEVAACLQATLANGKTTKQRAVVWATAIFTLVAFLVALAHTASATSPSPIQYRWFDILFIFQTAAATGLLHLNYSLSYSAFVQNFSWALGLFHSSNMQSSINKMRAKTGGTMDSEAYSDVQYINRKFSPYNVYANVNDIGSSTESFNTFVAANSISKRDLEAHHLSKRVQIASALAQNATTDLNTGLPVYTNTINIPEANAYSTVWFAFLALIAIFIAFHAVLFGFVILFEKMGHGRKGMYWAPRLRKMWWPFCIGNALRLCMIAFFPIFIFAFWQFHIGDSGLAIFFAVFGILLCFLPLLAAFLLTLRRSRTTSQLNPQVNPIYVSYRYFHSLGVLYRQYRAKYNWFWFAPFVLAMIARAGFIAFGPANAWAQVIGNIVVEAIVFVAMMITRPHKDKKGDWLGGFLSMCRMISFGLLVAFIPSVGVRPIPRAVIGFVIIVFTGIPVVILFFGFLWNIGYGYLWRKDTTRIEDGLEVERFSPTSSNSSVPAPIMKEMDAHDFVSSDAAARSRASLNGYGAGVGAGAGLAGAGRRATDHSGSGSGSSSSELHTPIDPPYPGHNYRPSSYPSGKQYTSEPYSPTSPVSQYHSPTSPTSASAADAYAQAANGSYPRSSGGYGQVDTESPSYRYSRDADGYDDEERAWAEARRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1B5</accession>
    <name>A0A1E3J1B5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030932.1">
        <property type="nucleotide sequence ID" value="XM_019176900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1B5"/>
    <dbReference type="GeneID" id="30194007"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130058" description="Protein BIG1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28594" checksum="FE6D419B25483A0C" modified="2017-01-18" version="1">MRSVLALAMLALPAWGMRDTAPFLVWNDNEDSAWQQALAGGKALVEGEAVYKGLKYLGCAWDNAVVVHVDKLHHSKLDAYNTPSDAHLHIPYLKGPSRRGLSGGLEDWASACEAEVVGSLEELDGGRQVVDLWIKEGEVVPWTEIPSAALIILTGSPPTHTKRQEYPFPSNPSSSYTYSESQTAPSTPTSTSRNSTIPPKTAPLLDRVQILTTPIITALLITFGIFIPLLAFAITQLVGIQVPPMMLNIIPREKMGKERKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1F5</accession>
    <name>A0A1E3J1F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030958.1">
        <property type="nucleotide sequence ID" value="XM_019176926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1F5"/>
    <dbReference type="GeneID" id="30194033"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="12742" checksum="F8A393E8931AE846" modified="2017-01-18" version="1">MVVIGVYTREEIVNPHPVAKRIGRMSPNKDESTQGTEMTSVSGGGSSSRAAWTTPEDHYTAHSDASQAADDLGHSIENAEAGQMSQGAIDDFKERQEEERRRKEELEGEIPSLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1J3</accession>
    <name>A0A1E3J1J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_04881</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031016.1">
        <property type="nucleotide sequence ID" value="XM_019176984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1J3"/>
    <dbReference type="GeneID" id="30194094"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="19">
        <location>
            <begin position="422"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN94737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="755" mass="84241" checksum="6859613E0FFDD155" modified="2017-01-18" version="1">MSSYVGKGTVPSWDALTKETPDEEADYGDYTYASRDHVLFCIDASATMHKPFPDYKDEQGITVKGKSALHQALEVVMRIQRSKVISGPNDSVALLLYNVDPSVVTESPGNHETGTFAYQSLRTINAEEMKKLVQLVAAAKEEYENQNPKEDSQEPEILGETFRPIAKSEEMNIANVLRACMFLFRDGGVALAGKKRIFLITDQDTPVGADGNRAPARTAIIDLGGYDVSIDTFFIDHPGHKFNPNVFWNDILQRDYGQIDEDEDPDADGLAKLEEVMNNLVIKYAPKRAQFHVPLKFGGKDGDIVIGITGFSLISEQTKGQPKKVIMSGPVVQEVEQKTGYTSSKTGTLLSANEVASAFEVGDEGKIRNVLEPNWFEGSDQEDERQEMLDDVLQEEKERRMREDDEGGGGSDDDKERYKDQAGQYMSQKGKSRVVARTRLQFSPEEVAQLRAVGVDPQIKILGFQSPDNARLEHSIKHATFIYPDEDKYTGSTRAFAALLKSCLKLNRHAIALCRLRTNWTPFFGLLIPQEEVLGSDGAQEYPPGFHVIPMPFKDDIRGKWPKATDNIPANETQKESMVNIVRRLRFKSGIYNPDAYPNPSLAYHYAQLQAFAFEEDLDPEDPDFVEELDRTRPKVKGQHKTAGAFMEEFNKAVELDERADRAEALAGGKKRGGKKKEDKVINEEDLPNVRGMYLQGQMGKLKVAELNDFAQYYNVPLEGKLKANLIDSISAFLKAEIDGGGAKEGDGKKKARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N5</accession>
    <name>A0A1E3J1N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031017.1">
        <property type="nucleotide sequence ID" value="XM_019176985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N5"/>
    <dbReference type="GeneID" id="30194095"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60045" checksum="A2DDA075EA3D3B49" modified="2017-01-18" version="1">MPPKPDPSPPLPSLSSPDSRPPSAPLSPPRHRPRFASPSSALLKRDPSSLSSPAISRLSSPDLDSLQGPSTSALTFSEVNPLFIHAHLDRHGSLADWLKQRMYKARERPPCVPDSELRDAFSAEEDGIGTLSRQLAETAQGVRDMSKELGETKVRSRIQNVLIVTKNNDEGLINLTRDLALYLMQRLPPPSPEGASDRYGGPSQDRGMVVYVDIALKESERFDAAGLERHHPELFQPMEPRRTPSSTSIGNLSRLSSAFTSASSANDGSKGQKGEDGQLRYWTSDLCANKADQFDLVITLGGDGTVLLTSWLFQSVVPPVLPFALGSLGFLTNFDFNKYKAIVDKSIDEGIRVNLRMRFRCTIYRRKGESTKAEETFEVLNDVEIDRGFAPYISSLELYGDDHHLTTVQADGLIVSTPTGSTAYSLSAGGSLVHPQIPATLITPICPHTLSFRPMLLPDSMELRVCVPRDARSTAWASFDGKGRTELHQGDHIKITASRYPFPTICADKANTDWFSAIARTLLWNERAKQKTFTIKEEDGEDGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J393</accession>
    <name>A0A1E3J393_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031308.1">
        <property type="nucleotide sequence ID" value="XM_019176833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J393"/>
    <dbReference type="GeneID" id="30193937"/>
    <dbReference type="OrthoDB" id="10286818at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="264" mass="30019" checksum="FE2F4D14A4442DA3" modified="2017-01-18" version="1">MVCSYNVVVPEEDSETHLLPVLLSHDNDIPALPARLGHMLIHIHVTPALKYSLHPSDRSRRLTATISTTQRLGIAHEHTTNERAVFLHLYIQNMVEYLGLCLAEGDDQIGTPISASVWESRVWMLRIVTARIWIGFQKAPFDSVDYDMVHGFEALQAPSKSLFTQCRKQVLKSELPSYVHPDVFHLLEMKAALALKDDLNYVFGCLQRFLLEIRIKGMDSIIAEAEDKETFLKKKGMLERIRRRKGMFSPFVDVCSIVGRGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3B8</accession>
    <name>A0A1E3J3B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031323.1">
        <property type="nucleotide sequence ID" value="XM_019176848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3B8"/>
    <dbReference type="GeneID" id="30193952"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="11">
        <location>
            <begin position="960"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137725" checksum="01D4DCF9A2BA6EF0" modified="2017-01-18" version="1">MPDLLSSSPSTPLSGTYILQLSTPAISVRRFTPFLPGDTSGGEGDLSEILWRTLAERASAEVGSMLDSGVGAVDANREVWLFSCSKVDIDLPEAFEELPIQTLTPQTLLACPSHPNPFECLSYNTCLISLKQTSESLKMCDMLANAIIETFAWKKGGRALFRASGVVPIESRWRPHVYPLSSTSLLLTITSPCSPAPPTTCTHHLLPLSLPTTFLSPLKLALPQTIRLEAAFDALIGRDWKKGRKSLLTRELVMGQKDTHEWAVYWVPLRQEGEGVLTVWPGHLAAPIKRVQEPEPSEPIIHPPKPESFDMMGTAHDLFEFFSSYREPSPRADGGTQAEDPDPAEDEDEETIDVDKPPTRPTSRRQSIVEEDSEFDDLFDSPSSSPVRQPIEPYQPPLAVAPVQPEPETDAMDFGDSLVHIRDPTPPPATRTRETVEEREPDRRDEVGLVTEDDFAFFDSPGFGDFGGMGVDIDSASLIPEAPPVNVAEGEMDVDDLLAGFGLPVDAPAPAPEPKEEAAEDETKPEPSSPSPPPLPPTPMTIPPKTKPPQLHPLIPHPYAPISLQEPPRFHAYAPPSPAPTPETSLVERLSAKRKQSYADDWTFEQSSDDGYNDGEEVDYTGPPTPVSDILSDSDEPTGTSSSRASLARDHTPSNSMTGAGQTEIKWHGTRCVGPEWVVLRDTGVEEVKTTWDGAWRTPDMMPLVDNGLKAGARKSADVDWEKVVREVITNRSFRRTVLGKRDADNERGRGVVDDVVNGGDALSAFSETRMTVPPQPQITTSTVHTPLILRLSISALSYWSELGLTPQSGRKNIKLGVVSDDPGQGREMVDGLKKGWEDLRFGQTEWVNVGKDGVIAGVQTFLDTSFSTLLKLLEAEHHLVLFIALPPGTHPPSRLFSPSFFTPANVTLIPLHLPAFPNRLTLNDYRVLSREAYDRLPLLLTPIQSRGEPLWPHDRYISAPAWTLASHKEQKPEFQLAFPIEGWDVLNRWRWWHLSYDVVPSTSSVLSKDVAVVVWISDDRGEAWELQVLSKEKDWKERVGKIHAWGKKVAGSGTTEWNLSVCRVGAMDREEWQAWRDIIANEPLTLLLSTPSGPATTCLTDPCPTAPPRPRAIANISQAILTDPNTSIIDTSLAGHITHLPFALPAELLSSPSLLPQTIYPQSTFLVTLPGKDGVEHKTVSYHLLSHKPRRPSQEKDKEAEKEDVKAVASEMAEEYYRLSCLARQRWGGEGWLDAVRWGRGVIEEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3C5</accession>
    <name>A0A1E3J3C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031334.1">
        <property type="nucleotide sequence ID" value="XM_019176859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3C5"/>
    <dbReference type="GeneID" id="30193963"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="626" mass="69764" checksum="7D92322E2AAB7945" modified="2017-01-18" version="1">MALVHPATVPEDSPQRPSRAKSVPNYADLLPEDASDASSVSDGASEFEPEVNEAVVDDVLHEMSRGEEELRGFVPLPPALSEASAEAGPSVVRAIPRKRVSVAVSAEASSSKLPSSEGAKRNYPSRTQKKFKCTHEGCEKAYTKPSRLAEHEMTHRGERPYKCVQCDQAYFREDHLKAHARTHLKVEVKPFPCTEQGCTQSFWTPSKLKRHLEVHDKERTYKCDHCDAMFNKHILLREHVVVVHMPAGTKPFICSHEDCSASFSMKAHLKTHEKTHDPKRFTCAHPSHTDDLPIFSKWSEFQKHMTDAHPPTCPHPECNNRTFKSNPRLRDHLKVHAEQEADRVAKEAREAVAVDGQKEPIPQLVLEGMMKSRRKRKRESVAADDDKPKKLKKAEGDAGKDHACDWMECEKRFKTASHLCVALELLLTSLQKYAMETHRNVVHLKIRSHTCPHADCDKAYAHKATLMQHLSKHDTAPPPGVDGESNGGTPGPSSRPASRRGSQSEGAMLTGALRELRRFVCPAWALGSAPPALETASQMALDPNIDPALQEDKHGNEQLLTISSPIQGEGAGISGVEGENEGEKGRCISRFWRVYDVRRHLKSEHGMELEDLQVRMLLVKTGQDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3L6</accession>
    <name>A0A1E3J3L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031235.1">
        <property type="nucleotide sequence ID" value="XM_019176760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3L6"/>
    <dbReference type="GeneID" id="30193857"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="16357" checksum="A2DC7CB09F8B6CF8" modified="2017-01-18" version="1">MPVFPAALKPQARAAYRDMLRSARVTFQGDPTRHQALLTALRATFSSPTLTPPPSASAEGSPAKVPIVQEESIGRDDVARRINEWKDVAKFLRKNVVQGVKSDDGVFKLRVHEDTELGDNADIKKPAALPTTPFPNRNRRRCGEAAPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4I5</accession>
    <name>A0A1E3J4I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031418.1">
        <property type="nucleotide sequence ID" value="XM_019176490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4I5"/>
    <dbReference type="GeneID" id="30193584"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="583" mass="61673" checksum="C9FCBE852214981A" modified="2017-01-18" version="1">MSAIIIQASAYPSERTPLISPDSRSASAPPSPAKDAPSKAPPLKDSISFTRFVTVLIGIWSANLVFAFQSTAIPTLAPEIGSWFEHAELASYLGSMFTLANTAVIPIYGVLMEVLGRKTAIVIACVLFGSGTILCALAGNMYTLIGARVFAGLGGGGLLTVSSVIVTDLVPLRDRGFYQGLMMTVFGSGSMLGGPVAGWLTDGFKVGWHSAFWVQLPVTVFCCIIVVTFLPSPAIPPTHTSLLSGLASLDWLGTILLVTSISALILGFSFHTSYLKPLTSPVVWGLLLFSIISAIAFLLVEMKVERPVLPLRLFKSNHLAAVMLSGFFLSIANQSFTYQIPVYFLVILGTTTAKAGLIISLCSGLGLATGSLLAGQYIRSGYPYRWLGPIALVPAVTSALIAASWTVQWPWWGYYATVFPSVLGYSTFLCVQLGKSSALSAHHHQPKATALLYATRSLGATLGVSIGGSIQLGALATQLRAQFQGVDHQEQIIDAILHSKSAISLLSPSLQPLALAAYSSSLSTVWLVSSAVAVLTLLCSFFIQVHHVDEEENKVFQGTGGGLNDDPPFGQALGEASSEGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6A0</accession>
    <name>A0A1E3J6A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L198_04098</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031630.1">
        <property type="nucleotide sequence ID" value="XM_019176220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6A0"/>
    <dbReference type="GeneID" id="30193311"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000109">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="276"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="463"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="481"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="504"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="654"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="664"/>
            <end position="668"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODN96384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="741" mass="81481" checksum="2669D27483BDE0F4" modified="2017-01-18" version="1">MPGATDTVIIALTILLPLLYFFRNSLPFIGGKPKNAPSAALSEKTAVEEGDPADFVGKMARAGKRCAIFYGSQTGTAEEYAIRLAKEAKSRFGISSLVCDPEEYEMNLLDQVPEDACVIFVMATYGEGEPTDNANPLMEFLAESEPEFSQGGNTLENLNYVVFGLGNKTYEFYNEVAKKLDSRLTELGAKRIGERGEGDDDKSMEEDYLAWKDPMWTAFSERLAVEEGGAGDVADFVVKELPDYAPEKVYHGEFSPRALLASASGGSTPVGAYGAKNPFPAPVLASQELFNVGGDRNCVHIEFDITGSGMNYQHGDHVGVWPSNPDVEVDRFLAVLGLSDPHRRQAIVDIESLDPALAKVPFPTPATYDAIFRHYLDISAVASRQTIAFLARYAPTEAAGAKLTQWGNDKEAYAKEVDGPALKLAEVLQAASGDSVEEPFASQTVWCIPFDRIVSSIPRLQPRYYSISSSAKLHPNAIHVTAVVLKYQPDASPVHHHEPRWVFGLSTNFILNVKLAQSGENAPSAGDAAQQVTMKKIPQYKLAGPRGNYVKENVYRVPIHVRRSTFRLPTSPKVPIIMIGPGTGVAPFRGFVQERVALARKAIDKNGPDALKDWAPMYLFYGCRRAGEDFLYQDEWAQYEEELKGVLKMKVAFSREMTKPDGSKVYVQDLIHDLASELAPLIIDKRAYIYICGDAKNMSKAVEERLMEMLGQAKGGSAAVEGAKELKTLKERNRLMTDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6K6</accession>
    <name>A0A1E3J6K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SUS1</name>
        <name evidence="13" type="ORF">L198_04213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
            <location evidence="12">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031745.1">
        <property type="nucleotide sequence ID" value="XM_019176335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6K6"/>
    <dbReference type="GeneID" id="30193426"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.140:FF:000003">
        <property type="entry name" value="Transcription and mRNA export factor SUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0010">Activator</keyword>
    <keyword evidence="4 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN96499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11262" checksum="ABB0474D0A29FC77" modified="2017-01-18" version="1">MSQTTTPDEATLNAIRQRLMETGDWERIQKLLRAHLEESGWVDDLKDLAKERARAQETPNLEALVKEISENAAGMVNESVRRDVTVEIESVLDREVDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6Z6</accession>
    <name>A0A1E3J6Z6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N,N-dimethylglycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031541.1">
        <property type="nucleotide sequence ID" value="XM_019176613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6Z6"/>
    <dbReference type="GeneID" id="30193708"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="393" mass="42302" checksum="49FBE054429B115E" modified="2017-01-18" version="1">MSSYIPLPSRPTQRIVIVGAGIVGSCLAALLSEHLGPNIVLIDRDIEELPGSTGHAPGFVGQYNELPVLTELAKRSVGYYSHIDGAFDQVGGLEVGQGLEERAEGAKKAGLEAHVLSKEQVLKIAGDFVRDDIPEGPAGVLYPLDGTANPIAIAHSQQRKASQNGATLLSVDVQSISDSRNGRLVRTDRGMIDCHSVILCTGIWAAQLFPKFTESVVSVAHPYHYSLPNNHESKTPFIRWPKQHVYARDHGMLDGIGSYAHAPIHVKKDELTDTAYGKWEPSFDDVLQNALTLLPSKTADTFKQGQKFNGLFSVTPDGLPLVGKVEDGLWCAVGVWVTHAAGAAGLLADQLLNGGAEKDAEVRKAVDPKRFEGVEGLEAKSLGKYNDIYNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Y0</accession>
    <name>A0A1E3J8Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031932.1">
        <property type="nucleotide sequence ID" value="XM_019176019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Y0"/>
    <dbReference type="GeneID" id="30193106"/>
    <dbReference type="OrthoDB" id="2129662at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="850" mass="93363" checksum="85A595568F7F9182" modified="2017-01-18" version="1">MDSHTNPQGAHSQSPNGEPRQPSPLNQDYSGFVSSVFPIPGSRRAGVPSSVSQSAEIPPQDIERHQRSSNGSIPSDPFHDARRGTFPTAGALPPHGRKIHVSYDLAASPEQPGSSHSQIHPISNSPQMPMSDNDSISAFLAEMPTMAEDPARHVLWTELVRLKTKSLELQIAEAKRKEKEAELELARLQSGAVSRNDGGSNAMAGPSGSNDLSAADIAGSQDTSSYGISQQIMPPQHQLEHHQNQQPYNVAQHQLYGAPQSGQAPCAMSPFDLDALLQTDTNNFLSWLPDFGGHDISQSDQAAPYGAMLSTSHDLPSTSEHKLVAQPSPAPPSPPDIHSPPTKRSKRTTEKKTVVEQACICTSCSEPLARVLIRAPKSQIPNPINVSIKCLKCAPVQQPSTLPDPNQTASGSAIGTVETRKRMRTSMEIDDEDAKVVERRAWCDVCQKVVGSGQLIGGRQKENISHMAEIVCVSCDSKYQRCTDCGGGGGPRVGIGKWRMKQVFHPGRKTCSLSHTRLGDRTRELGVHVTPTDFTPEQMKEVLSRCKALWNEKTLSRLAIPEMLEVDLPADFANPLRDFADVDDIVTRNWPSREAMIHGEGIDQTRFKRLLSLIWAHSKPRRTVRTVDLEEEWTKQADENDHQDMSTVLANVRRTNVVIPAGSELIGMWGGEWDMQNGSLLISTFIPFEGTDGDDSTALSVGEMITKVQGLLQEINTARTVQAALEGRQPVLLPPCQHLWTVSGGYIPLVRERFADVLVKKRAFVHLEEYLTRHPEFIECVKARPVGLHPDIHRPIPVSDSNDADASTPRPLILVRWLGNDFDAQKFLEIKQMEFGGAKGKTKKRPRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J932</accession>
    <name>A0A1E3J932_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZNF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_04155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031687.1">
        <property type="nucleotide sequence ID" value="XM_019176277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J932"/>
    <dbReference type="GeneID" id="30193368"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN96441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59989" checksum="43C21FADFC53FABD" modified="2017-01-18" version="1">MQSTSVRLANGEVVVANDHVYVSLPWSDRDGTPYNIARIIEFLPSSHSKKGTRATGSSDGLVRLSLYYRPADISTRNVADHRLLLAAIHTDVQPVSSVRGKCYVKHKDRVGDLLEWKRLPDHFYFAKFFDPYIKREFEVIPTETVNNIPHDVKIVLRSRYEYIVTERELVADLTDDYRSCCRCQGWASYQESVKCDTCKEHYHMKCLHPPLHAKPAKGYSWVCPPCSFQRGIDVENQKFRFGLQSSSGTAKAKPVKAKHRKVNLENRPPVTFRGWQWRYFGLRRPHIPQGGHQVDSFMDEIRKLDLAVPPWDVKRLNLAISSFTTLGFQPALEFMRTRKPQDFDLITFTSEERSLFENELERIGGLDTHSCGQILRRSPSEILRYFYIWKNNQLRVENEAVRQHHPLVTPHSRQPKTLGPPSLGKIRSAGDDRKENDSASVYGKATEGEHHFTCATCSTRLGEIWWKCPRTVPGEAMCNVCGSNYRKYGVITYSRSEDSKKIERKDNSLKRVKAVTGSIQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9A6</accession>
    <name>A0A1E3J9A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032045.1">
        <property type="nucleotide sequence ID" value="XM_019176132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9A6"/>
    <dbReference type="GeneID" id="30193220"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20844" checksum="F9292CB445D1E91A" modified="2017-01-18" version="1">MFRGPRSLQNNTKASSNTRCQKCLKLGHFTYQCKNAQPYVPRPSRSKQLESGSFGRDKPSVEVPDEFKNEGKGLADKILAAKEAERKKQEELKKAKSKKGKSSSSRRKRGGSSSESSTESDSDSSSSVSSRSRTHRRRRYSSSVSPHLSASPRRQKYDSGDEFEGDRKPRRRSPSPSVSRSPRPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B8</accession>
    <name>A0A1E3J9B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031777.1">
        <property type="nucleotide sequence ID" value="XM_019176367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9B8"/>
    <dbReference type="GeneID" id="30193459"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN96531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="289" mass="30745" checksum="E367E09EF72A68E2" modified="2017-01-18" version="1">MSRSTRPDGRSPSQLRPVHISINELDRADGSGRFAFGSDAILASTSGPIEVRLRDENPTQATLEITHRPLSGTGATPSRALTTTLERIFSSTSVLELEKFPRSLVQIVVQGLTAPSVVGGAAGGFGSIVATEEGKGKGVWPREDIEEDYIPASVLEERKVSPLSANSYTFASRAASLNATTLSILSAGSVPIKSLPIGVAVALGTKGEFLMDPEAAEERRARARFGFGWAWGKGIGEQGAELVWVESEGEFSREEWQQALQASKAASKQILDTIKLELANNYISSGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9C1</accession>
    <name>A0A1E3J9C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032051.1">
        <property type="nucleotide sequence ID" value="XM_019176138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9C1"/>
    <dbReference type="GeneID" id="30193226"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="59538" checksum="B7B61FB361FCCD69" modified="2017-01-18" version="1">MYQRDPRAGLFLGGSRTSGAEVRDANVAACQTVSNVLKSSLGPVGLDKMLVDNVGDVTITNDGATILSLLEVEHPAARVLVSLATQQDKEVGDGTTSVVLLASELLKRANELVRNKIHPTTVITGYRLACKEACRFMAEQLSTKVDKIGKDSLVNVAKTSMSSKILSADDDFFAPLVVDSMLAVKTINAKGEAKYPVKAVNVLKAHGKSARESIGVKGYALNCTVASHAMKTRIQGAKIACLDMNLAKQRMHLGVHITIDDPDQLEAIRARESDITLERVRKILATGANVILTTKGIDDLCLKEFVEAGAMAVRRCRKEDLRRIAKATGASLVSSLANLEGEETFEASSLGYAEEVVQERISDDELILVKGTKMVNSSSIILRGANDYMLDEMERALHDALSIVKRTLESGSVVPGGGAVETALSIYLENFATTLGSREQLAIAEFANALLTIPKTLALNAAKDSTDLVAKLRAYHNAAQNAPLNDPKRGLMFYGLDLINGEVIDNRQAGVLEPTISKIKSLKSALEAATSLLRIDDSIQVAPEQKPEVDEHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9Q7</accession>
    <name>A0A1E3J9Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_03969</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032007.1">
        <property type="nucleotide sequence ID" value="XM_019176094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9Q7"/>
    <dbReference type="GeneID" id="30193182"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="548" mass="59077" checksum="5903F46CC234582F" modified="2017-01-18" version="1">MYIPPLVYLIPFLAPAPPPPSTLTFKPSYAHSHYGPTNGSAAPELFLRDSSESASFHAQDYSLEGLDIFGLTQGDFDASLLLAEGEKEAGLTIRTKKGLIRRPKHRPPRITSWALSQRSKLSLAAYNSSSAWVAPSTSYNPDEWIEEEVTVPDVSDRQTLIALAKMASNAYVLPGGDGWYPVEGWNGNWSDSSGKGTVPFGWEEGADGLRGHIFADEKNETVIVSIKGTTAGVLGSGGPSAKNDKFNDNLLFSCCCARVDFSWSTVCDCYSGGNKCCQTCLEDAVVAESVYATVGTNLYNNITYMYPNATIWLTGHSLGGSVASLIGLSFGAPVVTYEAPGDLLPASRLHLPLPPGLPADLTGITHVYHTADPVPMGVCNGGYSGCYAAGFALESKCHTGETILYDTVQEKGWSVDIRTHRIGEVIDKVLKDPWPVNGTGEGKKQVDVSGGAWEAVSGLIQYLVDPARLALKPAAEPIRAHGTGEDDASALGAIRAQWGWGRRGPKKDKNKKEDDDDDDQWHKHGGVPKPVSEEDCVDCFKWEFGDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBR3</accession>
    <name>A0A1E3JBR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_03914</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031953.1">
        <property type="nucleotide sequence ID" value="XM_019176040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBR3"/>
    <dbReference type="GeneID" id="30193127"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000072">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="261"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN97351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="419" mass="49056" checksum="AD5F715311D72509" modified="2017-01-18" version="1">MAEGLEEWISDSNEVLILQLVRAPHDADVLSHEEVQAIEPFNPSFTYPIFGDTEKIFGYKGLDIKLQFASGSLKQYLNVVYDEKLASTTTPPDEIEPTLYKFIPPDYTKSDIQFETTVKEDAETFKPFGEKLGSYKLPSSSSQKNKKGKGKAQAVDTASLDENSEDTVVFEMYKASWNTPGFREYHRRMQLFILLFIEGGSYVHEDEDAWEFIVLFERRKRPESDIFTYHFAGYVSVYPFWCYPDRVRLRLSQFVILPPYQHQGHGSKLYSSLFHHMLSRPEVAELTVEDPAEAFEDLRDRNDLRLLVKEGLLTDPMFQSGVGQGKREARNEWESLTRKKYKIAQRQFDRLLEMLLLRQLDKKDEAKVKAYRLHVKSRLYRFNYEMLVQMTPEERKEALAKTYDSVVEDYERILEMTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBY9</accession>
    <name>A0A1E3JBY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 32 (Vesicular inhibitory amino acid transporter)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032260.1">
        <property type="nucleotide sequence ID" value="XM_019175770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBY9"/>
    <dbReference type="GeneID" id="30192855"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF696">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="70"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN98398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="511" mass="55058" checksum="7DCD8120CAE73BF7" modified="2017-01-18" version="1">MSAGSHSSTISSQNHGISLAASSATLVEPSESTPLLHGSESIKGNISQEVYSDCEEEAEGREVDVYVPGQATFNQTLLNVLGDLIGTGLLACPIAIAHAGWVFGPLILCAVCGITLWTLKILVRIIEKDRSMRNFADVARYGLGPRSEKWIAALFISDCCIWMVALIVLFSDSFEVVLPMLSSNQWKVVGLAVIVPLNFIPLRYLSWTSALGIISTWTLVAILIFTGLATPTSPGSIWHPAPTDLWPVHGPVKFGLSFGLLISGFGGHFLVPNLIRDMKHPEQGERVCEVGYGICIVVYALVSVFGYLMFGRDVSDEISRDLAKTSAFSPLMASIAVWMVAINPLTKIPLGLRPLTDVVYSFFNLQPTIFVPKAHSSSASPTIPKPNPNDLPSSPSSSVSSTATLEDPHYLHALSNAQRHHDRRETLKSVFRALVAICLLAFFVAGALVFPSFETLLSIMGGGMSVVTSILIPIAAGANLWGWSWYSRSLFGISSVVCVIGLLCALLNNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCA9</accession>
    <name>A0A1E3JCA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032380.1">
        <property type="nucleotide sequence ID" value="XM_019175890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCA9"/>
    <dbReference type="GeneID" id="30192977"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="782" mass="86998" checksum="DF5F1271F0CAEDB1" modified="2017-01-18" version="1">MDTQTLYLKPEAFKNGGAPRWAATGRTLAAALSPAAGEAAIWVSKKPSDSPNGIEKLPDASLSLSDETILFTSLNSFSQPLTHLYTESHLLFTSLQQIFADSGRWRLSSVGVGMGGGADAWDGKGNFGVQDLLGPPDAETVINMRRLADLYLDQLGDLKQIPDIDDSLRERFAEAYNILNLAEILYLPVDGKGEGFIGEELLDWVNEVDVAPDNQLGNEIMSCQHAWEHPSFWPYISRSVLRGFHLPAASFLRSLSSHSHQPVQKLASLLAQHLSIFPRSSETRWRVDLEFLQAHRQWLSRFRSELATHLGGKGKGKWFEGIQDGQKWEGDFRSVVELMEGKMERVLEESGDWREALGAWGVLVDVDLRRDHLPEIMGLITEKIPVETSIQEHVVESALCSADVIKALMASYSLDPWLSAHLSDLLDKLSLIPDDEEHFDISLRDFFLLEYAQVLQTHPAHKAFWRVTCDYLAFAGEEGRGRLKEHLRRIDIPLERDIKGKNKETPVHADVGMDVEVTPAETQPESIKLLDEVRSACTEFQLDDVWREISQVLATRLVHARQYGMAATLALMARDGFALSRIAEKVLQSFVDEGPEEYLALVDTLPPTLLSEAPTALLQLQESASAPLSFPSSNSISVFASRITFLSEFRDYILFLGQDGGREQAAGKVVALLTSGIAPTGFWGVLLVESISLLEDPEILFSTNETFELLRILEEVITNASFAEEEYLGQIALYLDHRSPKQEQGSKSGKGKATTHDARRKLEEARLALSRNLARAMVSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JDR5</accession>
    <name>A0A1E3JDR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032108.1">
        <property type="nucleotide sequence ID" value="XM_019175618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JDR5"/>
    <dbReference type="GeneID" id="30192701"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="861" mass="92589" checksum="29E46A61250AB314" modified="2017-01-18" version="1">MSPPPQRSEEGEDELSPPELPPPPPPLDDDPTSGITHIDPNDPYPRRPIITPINKFNLRPPPSSDDDDDQARYSFSPISDDDEDNYSNFPPLTYPQPDDPVVQALGVAASSAAIANGHEEFSISHEDMRRYRTGAFVRVSCDVEGPVSKDALSQMTVSEAVWRKWEEVGGLAKGAGGLFRFAYDKGGREYRPEMTHIQAIRLVISASPRRMMTLAQIYQAIEERWPWHKTAGSTWKNSIRHNLSLNDCFVNADRPNHEGGSGKGGYWVVNDKLSGRTARKGKPRAPQSHQDDLYTITPTTPLSLTPLSTTHFPHGYPIDPSTIPAGYSLDRQHVGQVPPGYTVDYMGKLVKGVKHPKRRYAQEDDSSSSSSDDDLPPHGQSPKKSKSSLPPSSSSTTISKRIKKYRARNSVFPSIPIELPVRGPNWEPREKVHRPFVRPDWDMPLDNPRVGVWNQIPVGFGESREREAGRDGAEEGASRDAERGRAGGEGKDGQGRGWTSNHPVLETRSSKHHSAPSTHSTHPPPSPSYPTPNTSHLPAPFQPHLLPSPLGRQGSAALPPITIGGGAAGGGAAGGGAAGGGGGSGGAGAGVGLGMGLPGWDSGIPHTTDSPGSTASPPRGSPTKGIPPRPHALSNSNSTSPPRAGGPQTPLTPSHLFPPSLSSNAKTHPPPLCLSVSVSISPNQPHPQNQNQNQSLPPLTSVISKAHRDPASARRKTKEELREERERKERRVERLRKEGVAFRVAKAQAQAQAQAQAQAQSQAHGHGQGQAQYVPGQGQQIQVSMRGREERPGQSGQVQMDGLDGMEGVEGVEGMEAVEAVEGMDGETERRRQRDEQLDRAAEGVQGVELLALAAAAEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEZ6</accession>
    <name>A0A1E3JEZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032479.1">
        <property type="nucleotide sequence ID" value="XM_019175376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEZ6"/>
    <dbReference type="GeneID" id="30192457"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1117" mass="117308" checksum="6E1E95056F958D41" modified="2017-01-18" version="1">MASSPNPLTPLPPSIASSADSSHTAPNTAARADQVLYRFYLKTVAVLVEARLTHYGSQTTDKKDRWFNLILPEIDLHKADLQVYRSISTYQPFTPPELPSASADSCSIPPLLIAFILDTSDVPHGQALLWNRSGGKVALDIGSQSAKGKGKEKEERLGIVLERWTVRAETIAQAPSGSQIAPHTAYRLGIIHFRALHSLVRLLPAYRLYRRLRRSNTGLRMGIKLWGAEGYDNSPQGLKEAWEVMESDLTSLDKGLEELVLGGEEVEPESVEKYDFPRIDLFGNGYTVQAEYRPEVDFTTGDLEAVLSEKFVDMDEDWFTPTVAARRRSDSVAPSTPENPRTIRKSSLPAPIPSSNSTTSPIPQRQAAATVGSFASGGSYTRRRQVSAAATAPPSQKKDKWGALGEGLAFAGRSPAASQVEGQVPPSPNPGGIVAARRLSGHSIQPFGSSSPSASLLRGTPPHPNTSGGAPIPTTSARPSIATARQSTSVGRTSSFLSQSGRSFTHAQIANMYSGSASPPVTGAMSGIHQPPSPTAHQGLWKGDSPISPSSLTFAKQPVPRRVSNSRAGFTPGSMGSPFVPGSIEKDGSLSTSANAPYLIKRYSSSISSRPSSVNQRTALSVSHGSGDSASGSYGAGGGLRRTNTRESGLRHSVEPKREATIKVADADDIQAFLRTLDSAPAPSSRNQFGMPGGSAYTSMGSSHSRGEIPTSPLARSRRQSPSQLHTNGQVPKTRAWVDEELKRFAGRFDSPGDLPISPGLSKNPSQSATAMSSARGSFSQGPGTPGLLSASRPSSAAIKIASGRGQGERDAELVFGSRRRSSGGPSPLSQGLVAPGKSPLGSPRRTLGSVEEHGALNRPALDKEEVHGGQGARSLPGSSLGVTTARDRSSDPPLRSAAPYGYPYPTPYPPVSSRPSDLSPQTTGSASTDSYTTASPVAGAGRTQRRGPVLLKGGFGGTSASNTPSHSPVRDRSRAGMPSSSGSTGLGVVYGHGKEARAGSVPLDKEDRVDIGRRGSTSIAQVHAYNSGLPSPAISERRTSTLDGLGGLRSASGSGIARIVGQRTAPSSLGREDHTRRGGAEARRGRSDEQSTEGQEEDEGAEGIVGDMSGLGFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI73</accession>
    <name>A0A1E3JI73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032776.1">
        <property type="nucleotide sequence ID" value="XM_019175044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI73"/>
    <dbReference type="GeneID" id="30192117"/>
    <dbReference type="OrthoDB" id="10620495at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18623" checksum="A41E3491D5C47482" modified="2017-01-18" version="1">MITVAHDRTWSELAPSQGRTHPSNSLTILRDNDILFKDGNLSPLPDSTVFIVSNIDFDADKKNLSRKTIVFPRYVEGATIDDYSKSAATASRMNKDIFEGLERTEDDWLHEAFTNKDPEVLARQEKDLLSPLLDTHDDYKSVQILSVGENDFKLAESSIYDDMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIM8</accession>
    <name>A0A1E3JIM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032900.1">
        <property type="nucleotide sequence ID" value="XM_019175168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIM8"/>
    <dbReference type="GeneID" id="30192247"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24507" checksum="11AEAE312275C1D9" modified="2017-01-18" version="1">MTVVSPLIRRTTIQVGTAFEKHALAFLTASMSMSLRRVGGAGDGGVDLKGWWWVPADASSDTVARREMARRLRVIAQCKAEKKSVGPRAVRELEGVMSQLDYRGEQSSSEATVALFISQNGFTKNAMIHASQSRTPMMLLHLPGGQYVDAPLLSSSPGSNSNVETSIKVESAWWNRALSHGVLGGRLELRREMVTNGRGVVGTNVGLWMDGARVDRLVPETGVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIN0</accession>
    <name>A0A1E3JIN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032877.1">
        <property type="nucleotide sequence ID" value="XM_019175145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIN0"/>
    <dbReference type="GeneID" id="30192223"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="664" mass="72850" checksum="8E99AEE8554BC75A" modified="2017-01-18" version="1">MPPPPQLTSHLRHNPPAPSTSGDSESTALPGAPVEKGVEVGILRELAKTALVESLNDIQGAKSLVLDPALAGPLGLVTEVALLKNQAVDKMFWLEPGPLSVNTRNVVWLCRPKTGFMRVIADQIRAHQRTPPPGGPLHYTILLVPRVTELCRKVLEDQGVAGDVTLSEFKLGLIPMEDDLLSLEMEDVSRDIYMNGDDTPIYHSSLALMTFQRAFGLFPRIIGKGDAAKKLADLLRRHHSSGPSQYTEIEPSSKIDSLIIADRSVDWVTPMCTQLTYEGMLDEFVGIKNGHIEVDPSLLESNPAPPQPSSSSLPSTPLAKKRKHHLASDKDALFSDIRDRNFAVVGSRLSKLAKRLKDEKGNAKNLKSVQEMRSFVGKMGGFQSEQQSLKLHTELAETLMNVTKTEEFNKNLEVQQNLVAGYDVAAQYATIEDLMYQQAPWQTVLRLVILASLTTGGLKPKVLEGFKRDFLQIYGYHHLPLLVNLQSLGLLRAPPPTPQTFSALRKSLRLIVDDINDAAPNDISYVYSGYAPISIRLIQCITQKNVILSGPSEEDVQGRRALPRAHGISGWKGFEDLVEGLPGAVVDVKQETDVARDVPRITEDSTTTTVVFFLGGCTYTEIAALRWMAKQAKGRKFLIATTGIITGNSLIEGFGDKTPVPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIQ8</accession>
    <name>A0A1E3JIQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellular nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032963.1">
        <property type="nucleotide sequence ID" value="XM_019175231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIQ8"/>
    <dbReference type="GeneID" id="30192311"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130437" evidence="3">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO00771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="20157" checksum="88DD3DEEB4A481AF" modified="2017-01-18" version="1">MTGSVCHLHAFSLSPSGHVAAACPAADPTCYNCGQPGHLSSGCAQPKNKACYTCGAEDHLSSACPQNPNAGGGFGGAGGAGGECYRCGKPGHIARMCPESGDAAGGAGGFGGYGGGYGGGAGFGNKSCYTCGGVGHIARECPSGAARGFGGQGNFAAGPRKCYNCGQPGHISSQCSQEQGRTCYSCGQPGHIASACPAAGGAAPADAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW0</accession>
    <name>A0A1E3JIW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM50B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033031.1">
        <property type="nucleotide sequence ID" value="XM_019175298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW0"/>
    <dbReference type="GeneID" id="30192379"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="333" mass="38317" checksum="65496CD403E12573" modified="2017-01-18" version="1">MSGPPEESLRTLVLTKQREKEAAEIQRQKEAITKDSQRDHTVDRFVGVTENLDERLIKTTVGLVSLSEFQKTKSDLEEAQRKLAAQVKTDKPNSNQKVRKAKKKNRSKLSFDDEGEDDSGLAEFSVDKRGEPDQNPKKKSFKNPGVDTSFLPDRNRELEEAQERERLRKEWLAQQEKTKNETIEITYSFWDGSGHRKSVECKKGDDIASFLNKCRQQFPELRGTSVENLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDVRMVSDATVEKDEASHLLSGIPNETDNSTSLMLERWLNDRGITGINTFFQLPDGRYTIQTKSTVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJ46</accession>
    <name>A0A1E3JJ46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Niemann-Pick C1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033025.1">
        <property type="nucleotide sequence ID" value="XM_019175292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30192373"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1188"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="588"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1333" mass="145799" checksum="7DA7AE971E63B6A0" modified="2017-01-18" version="1">MSALSAPPSRGPGICAMRGSCGRTSIFGADLPCPDDAHATQTSDGLLQLMANVCGPSYTPPDHVCCTYEQLATLSDRLQQAAPLIASCPACINNFRSFYCDFTCSPDQSLFLSVTSTQKTTEGKDAVKEVDYEVSTEFKDGFFDSCKDVQFGATNGFAMDLIGGGAHNASGFLKYMGDLRPGLGSPFQINFPDNDDSRYTRQPLSCSDATDINARCACVDCPSVCPELPYVPPPASNKCHVGSVSCLTFSLLIVYSVTILCGILFYTWKQALKSRQRRYERVALLDPPQSPTLAGNGNNGLDGLIGRGDDAESGPSGSIHFRLGRGASLLDPLEHLQPKQNRINASLRRFFYRLGLACAQRPLQVFTLTAFVVGLMSFGWKWFEVETDPVRLWVAPGSESATQKHFFDDNFGPFYKSEQVFITLPGGSPVNHDTLKWWLQIESDIAKLKTNNGVGLEDVCFAPAGQGTPCVVQSISAWLGEDMEEWGEGWSERLADCAERPGECLPAFGQPIDPRLVLGGAEGDWLNAKAIVTTWVLNNYNDDRVNPAEEWETVLKSYLISLKHPSIKISFSTGVSLEEELNKSTNTDVKIVVLSYLVMFLYISLTLGGGLPPNVIQAFTRQLYRAATRIGVYTRILKEPQEDNSDPSPSISLIPILLSINSRFSLGLFGITIVLVAVASSVGIFSMMGVRVTLIIAEVIPFLVLAVGVDNVFILVHELERQNSLHAQEPVRDDDADSVHSGRQPSGTSLAPEERVARAVARMGPSIMLSSVTEVVAFALGALVPMPAVRNFAIYAAGSVFLGAVMQCTVFVSAMALDLRRAEAMRMDCFPCIRLRPPIGLYDSDTPRSEGVIKRFMRTTYAPLLLRHEMKQLVLVIFGGLFLVATIGIQHITLGLDQRLALPSDSYLVSYFDALDSYLDVGPPVYFVVQGGDASSREGQQRLCGRFTTCLELSVANSLEAERKRPDSSFIASPPASWIDDFLQWTNPTFESCCRVRKRDPSVFCAPRDSERLCRPCFEGSDWDSTMSGLPEETDFMKYLEQWLVSPTNAECPLGGQAAYGAALKLSEDNTTVAASHFRTYHTPLKSQTDYIDALTAAQRISSEISHRTGLAVSPYSIFYVFFDQYEHIKSTAVEVLLLAFLAVLIITSTLLGSWRTGGTVTFTCALAVINVMGIMGFWGISLNALSLVNLVISLGIAVEFCSHIARAFMGAGSGLPLDKADGRREMDERAWTALADVGPSVFSGITLTKLIGISVLALTRSKLLEIYYFRMWLSLIISGALHGLVLLPVLLSYVGGQGYALEDTDEDWVTSQMRRPMDYEYAPFADTDSMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM20</accession>
    <name>A0A1E3JM20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 zinc finger protein Zas1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033146.1">
        <property type="nucleotide sequence ID" value="XM_019174767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM20"/>
    <dbReference type="GeneID" id="30191836"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="928"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO01894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1184" mass="128906" checksum="2896814AF4DB3647" modified="2017-01-18" version="1">MAAIPAPADSPVVTEPSPLSLAPPPPPTPATGGSGRGRNKDGKEKESFACTFPGCGQSYSRMEYLKRHQRKHQDDRPFQCKDCSKAFARSDVLLRHRRRCHPTPPPVDRDTSPPPSNRIYNNMPVSSSRTDAREQSPPRARGRKHARQSDAADDQRDRSRPRIDPALQHEHEPEYAAEHGANGEHDERYEEERGYDGNVYGQYYGQTNQDDHPNYSSHLMPMFAQNQAYHSLNDPNHLEDASVLLSMAYPSGVPGGEGQQEQEQRDLPDWASNPTINLIMETAVASANGEHDALPKDTNGDGQEGADASAEKENGTTQAEPTAAQVISNLAEAAAAPQPIPNGTSNDNPAVNGDSTEGGISSEVIDPTLQDGTPGSEGFLNAMSWLSGLDNQGVLNLNKSSTLGTSTLKMGFTPEENSFLMTSLFSPSALNASLGGNSNDGSTEQASTPHILYILEQLAKYEVPQTIANPNPERPLLRLDHAAMALRAGEAFDQDSRFYLPAERFAGCYQIPHWALPPLKTLSVMACRTFHTVLNHFSFVHLPTFKLVDTAACLAFAICTVGGIKTGNASLSDRFLWRSPEGNGRPSSVGAGALDGPVVPDQSWESLYEDNWYRCTEPARAAEVKNVANWANGPVVRSEKTNMLVKSFSLAKGVLMTEYNVALLQALILYHAPNFLSENERERVPANMFLGTIVNITRQIGFFTTENDHVTPSISLPSEPFTPHELDRAWHDWIQLETRRRTAFLVYQLDTISSFESNIPCILSGCEVAYLPLPAPDSLWKAPNAQSWLKGVKNYRPMTLDEAMRRTFFLPTYGAFDALHEKADTQFYNLLNQSDYGPFARMAMVITLLRGIIDIGEGKRDRGDWRDLTDLWVGCSWLKPGKQIIAQDGTDLGIITRESLKERFRLGLQKWREGWDFDSLCSSPTRAATRHYKRPGAASAGMSPESDSTSPREDEQSIPKETLNYCEDALPLYWLASGLLGAIISNTTHKPGQNMFSGFNYGDMLKSARTFTRTGEGVPVKLRNMSASHARNERHPSAGPPVYGDASRNPNMPTPTSASSSASSGPPSNPPASLDPSTHSSHSTIPTSVSPPDQAGNDIMNQELSSLAEGMSDGTFAGIMQALTAGSGDLSMQMGLINEQGEGEGVREGAGAGAEGGNEGNGGGEESLQGLSDQDIAKQLGFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMD8</accession>
    <name>A0A1E3JMD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033266.1">
        <property type="nucleotide sequence ID" value="XM_019174887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMD8"/>
    <dbReference type="GeneID" id="30191958"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO02014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="12053" checksum="1C6EB136449B933A" modified="2017-01-18" version="1">MTLSQTPQVVTIDASEPVEKIHEIIARDGGVIVSNLFSPELLKETEDALKPWFDKREGSSRIYGLLGKVPEPTIKALRLPIWQSVMAMLLNDEYFSYVGDKHLPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMF5</accession>
    <name>A0A1E3JMF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033292.1">
        <property type="nucleotide sequence ID" value="XM_019174913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMF5"/>
    <dbReference type="GeneID" id="30191984"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="238" mass="25160" checksum="8A8AC2FC31368A0B" modified="2017-01-18" version="1">MIAITYPTAHTITVQNPRLQLLNNLRNKVPALMTFIAIPSVRHAQIMALTGLDGVIIDCEHGHIGDDQMHNSVSAISALGVSPIIPVRGSQPDLLKRALDTGVHGFMVPMINTAEEAASVVKYSKLPPQGLRGQGSALPAIVQIETREGVENVDAIAAVPGVDYLFVGPNDLAQSLLGYTPAKGDEPVFVEAIAKIVAAARKHGKWVGRLVNDGPLAVQALETFDSVAITGDTKAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JP56</accession>
    <name>A0A1E3JP56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033169.1">
        <property type="nucleotide sequence ID" value="XM_019174790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JP56"/>
    <dbReference type="GeneID" id="30191860"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="457" mass="51379" checksum="B27769867E94A3CA" modified="2017-01-18" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR65</accession>
    <name>A0A1E3JR65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033422.1">
        <property type="nucleotide sequence ID" value="XM_019174370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR65"/>
    <dbReference type="GeneID" id="30191430"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="224" mass="24885" checksum="B8081F040282E8AE" modified="2017-01-18" version="1">MTGHTIVVGTSLSKLTPQGTVGDGFDVHVAIGITKSGAQPSDKAKPQHAVSELTARTVCHTVLMAISLVSACHELTIANMDEKTKAGTDLAQLERQWQMLVYEMAWKTCTKDGRMKMGHNVEFSKLTTCRAFDKAVGLQSAHPKAFLSFLRLRYKVRPNPLLSPKVLTDVRAWGTNSAKRIKQWVAEEPEKRDVVEYIEQVNDPYVTFFLARGAIKEALKSQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR96</accession>
    <name>A0A1E3JR96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033441.1">
        <property type="nucleotide sequence ID" value="XM_019174389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR96"/>
    <dbReference type="GeneID" id="30191450"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="297" mass="32860" checksum="973F38A46841E87C" modified="2017-01-18" version="1">MPTTGSSRSASTRFTQTPSNKPSKPPHKDPNPPSQKKASNRGPYAEKACYPCRKGHRKCRDIRTITGKPVCGLCADQELECTWPDDGPPTGHGRTYDRWNNTYTSRDPPHPSWDYTSSEYDAEGGDGDSNSNITDEDEEGWSSEHASGGNQGVDAHETHHNSIAQQIDNQSSPARTHHHFPHTVRPRPRTQQTPRVPTTGLQLPLFGQQQPPVPAATASATDDTSVSDRYRQPSNSHQAPPPQPRYPDRLELLATAAAAVEGNRSDLGRSLNNGAYGRLRIKDEDEGDDDEEYEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU33</accession>
    <name>A0A1E3JU33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033708.1">
        <property type="nucleotide sequence ID" value="XM_019174656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU33"/>
    <dbReference type="GeneID" id="30191721"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="514" mass="53369" checksum="71C32627EA8F490F" modified="2017-01-18" version="1">MPGGMGAGMPGQYPGGMGGYGGGGGGGMGGGLNPMMTGGGMMPGVQGMGGMAQGGMGNYCQALHNLGYDYNPPSLGYTAKADWSPWDLANAQYNGAHLDRGFFDNIVGLCREHQALKNQASLQDPLLHPHPHSFERPHTPPSPLRRTDTPRRTRFALALDSSDDPPAERNILPSTTIQKISTLTNFFTSRHLSEESARDAHRRVYYANEGADAGNKTLGGAAAYQAYLIWDRDHYSAYHANPSQENRERLVGLAVAELFSLWDRVMPRSTRASIEDASQYAAATAKHLFDRHYDIDRNYNNYTRSNAGGGSHYYGYRDDSGASDVEERNHRRRSMYGRTQPPGVMGMNGGLGQQMGAGQMGAGMGAGMGGMGMGMQPGMGGAMGGMGMSGMPGGMGGMGGMGAYGPGAGMGGMGGMGGMGPGMGGGMGGGYGGGGGMGGMGGGMGGMGLAQGMPPHGSFGEGQAAPGMHPYHYGTQSGVAWGNQPIDSGGNNTFLQGGGQRGFYGYGQPQSRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW57</accession>
    <name>A0A1E3JW57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033746.1">
        <property type="nucleotide sequence ID" value="XM_019173939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW57"/>
    <dbReference type="GeneID" id="30190991"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="9">
        <location>
            <begin position="473"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115982" checksum="7D4FE7851AD3532C" modified="2017-01-18" version="1">MASTAAKDYGNFKLLKSFDVDFAPIQVSKWKSEKTGLTVVLGKHDAPITNGYFAIASEIFDDTGRPHTLEHLVFLGSKEYPYKGVLDQLANRAGSNGTNAWTANDHTAYTIATAGSEGFLKMLPVYVDHILHPTITDAGFVTEVYHLNGKGEDSGVVYSEMQARENTAGDVMALEGQRTLYPETSAYRSETGGLMHKLRVLTAQQIRDYHSAYYQPYNLCLIIDGAVSIPELFQVLNDKVEPLILANKPTTSQSVAPADWKRPFVESSTSNPLSIGRSITKVVEFMEEDESVGEVMITFLGPPPIDYTKNLALSILDSYLTQSATSPLSKEFIEIAKPLCTDFSFYAADRVNKNEVVVYISDVPAKHLEDIADKLKAKLAKIVKEEGIDMDRIQRVLKRDERKLLDYIESQRTDVLSDAIIGDFLYGAADGSDLPAAFNDLKDYATLHSYTAQDWVNLLDQYFVSAPSVTIVGKPSAALSAKIEKDEKERVDKRKAELGEEKLKELEKKLEEAKKASDVPPPSEMIKDFPITDPNGLTWIPVETALNPAVGDNARSDQGEVQNIIDQDGENLPYQAHFSSVESNFVTVMALFDTINLPIHLKPYLTLFQNALFSLGVKRADGTVLSHEQVVNQLDDLTVSQLAHFEIKGNFAEVMVVRLKVQKDQYEEAVQWLRDLLTGVIFDKERLGVIIAKLTQELPQEKRDGNTIAVAFANQLTYDSSKSASQTCDLLARLEFIPRVGEMLAEGGAKAEEVVNALEELKQTLLDTSKLRVAVQGDITSLPNPRSVLARSFLQVTQAQALAPLSTSRETLTELGKSPSKKCIIIPMPAIEGSYATFYASGPAGHAHPDLPALRLASSVLNALESYLWKSIRGSGLAYGAHVRVYPEAGLVGFDVYRSPNACLAYEAAGKIMRGLVDGSVELDQDLVDGARSSMTYDYARRSETAATAATTAYINETLKGLGKNADQDMLKQLPQITLPEIRKVIKKYLMPIFESETAIGAVSVSTSKAEEVEKALEGLGFEVERKELPVLKGDEDSEMGSVSGSDAGSESGSDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWG1</accession>
    <name>A0A1E3JWG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033856.1">
        <property type="nucleotide sequence ID" value="XM_019174049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWG1"/>
    <dbReference type="GeneID" id="30191103"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111839" checksum="8B916B1D4D831379" modified="2017-01-18" version="1">MSTRRRQSASASTPRPDGDEQGAPRRATRHRNPLPPTSGPLYPPLPPKQPKHATTEGSSSRSPATWGAKEIMEGDEDAESDVARPGKPSGGLDAPAELNESAVVLDEDEDDKDGRGPHSGSNTSLTPPPPTSDNEEMDLDIGLEAQEEKEVEAGSASRKDGDRPEGEDDQGSPQHQPAERGPGDDEVKSEPEEENPLPSAPIHANGDDKVDDAEVKEDEDNDETVPPARTRNGKPSRLSHIPTPYDTPASSATPDTAMARSGSRQGRKRRGEEQLLLDDHLLPAEIRRTTVKKTEDDEEEEEEEDDDEEEGDGEEEQDEEGDDEEGKDITRCVCKREDIDVMMIQCDQCNVWQHGECMGIWGDDEAPDEYFCEECKPERHQALKKWLRSRGRNTAPFIPPAPEKLEQLHSNRDPFPPSQSKRWSEPSVIEAPPPPPISKSARSHHKKDKDPLPSPVETADSRRTRGRQSTVREKPPSTSYKKEGRRSRKSLGAEESDEDDSSPQPSNSSAPAKKRSTMNSRDAAYEEAVKAALEASKREMEGQEGDEDIEVVEEKQPEEKKEDKEKGRGGKRRRNEDEEEEKEEEQEKPKKGKRRKEEDPEVESGAPASQSNKPKHPNQYTYRPKPPSSAAPAASPSRRMGTTPVPSSSAAPLHHEHGTRRAGALASAPVVFQPLSVESANHLNWNLPDHLIPFAEALPSDHPEALEVPAPRVMAYLPRNHFHNQQYGPFTENRDEQGRLRLPTEQQTRETVGHQTTQLEPPARIKFPPKRVTSVDIKRRIRTMLEFVGKHQVDESNRVKRAKLIGIETTSTGVIKRREERREHAEEKERRADKERERLERAQEDGEGDTSMEEAEALPELGRTPSPPPVSAEAPQRKSVQLMTELTERLIAFQEALSSNDFTALENGYAASVSVSPRLPEDSVTVNLSAPKEGKSNHISEPHLVPRIQKDPTPMSNGAPIHETTSEIDGASEGIEVYRAGLVNKVMPMDETEREVARKVEEIIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXC3</accession>
    <name>A0A1E3JXC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034061.1">
        <property type="nucleotide sequence ID" value="XM_019174254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXC3"/>
    <dbReference type="GeneID" id="30191312"/>
    <dbReference type="OrthoDB" id="2576597at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130636" evidence="3">
        <location>
            <begin position="39"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO05406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="621" mass="60650" checksum="012FB56AA09AADED" modified="2017-01-18" version="1">MPSSRSNTRTKTKPRPLSSLTRSTPLLLLLVLAKRATGQYIPPQAAGLRRAAGFGRDDSGERWVEGMGRDLEERDDGGDDTQSSTSRSLYLVSSSDFCLFGPPSTSSKISETGGNVVSWCTREQHGNRLIPDGTLRGVTYVKAPGWVQVSGTGDFTQINIAEGDYGGQFDSGDNTPDGAVLYTTDDNQAADSWITMISADTFCLRACSDPTYCPLGYDEMGCYFYTSNGVGWDGVYQDCAGDDGDPPGVVDGVTYTQGNDPTPTPSTPAVSNCNPGSSVANGQSATAAAAAASSDSSESGSSSDSSGDASESGGGSTSWVPVQTCVPCTDTASASGSEETGSGGASSAAGGASSGAESGESSAASSSAKSGSSASGSSGSSAAGSASGSGSEAGGENGGTQQVGITQLSGGSVAAVQISAASSVNASTYSGSLPSPSNSASESSGSSGGSSTITSAPASTGTSAAGGENGGDALGARGWLVKKDEETTTSDGKCCFTTWTPSVVGGAQETGAASSGGGSSSSKGNSSGSGSVVLSGAKTAGSSSTGVKDVSESSTSGSVRASGTLGSESSTASGNTSGNGTNDTSGALRLEITGIGSGMGMLLWTAGVVVMGTVVGGSMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYV8</accession>
    <name>A0A1E3JYV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smad nuclear-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034052.1">
        <property type="nucleotide sequence ID" value="XM_019174245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYV8"/>
    <dbReference type="GeneID" id="30191303"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="30985" checksum="7577B80087CF5FB4" modified="2017-01-18" version="1">MPASPSHRRPSSRSPRRDQDRGDRDSYRRRSPDRRPKDSGYADRDRIRDREHSRGSREPRMNGERDGGYRGGVKREKDGSYGAREREGERSKDRKRYDEDAGRDGPDGPAVEPEKPNFGTSGLLAKETNTVKGVVVKYNEPPEARKPTKNWRLYVFKGEEQIDLIHIYRQSCYLIGRDEVVTDIPIAHPSCSKQHAAIQFRQMTERNEYGDVTSTVKPFLIDLESTNGSFVNETEIPKTRYYELRSSDVIKFGTSSREYVLLHENASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYZ2</accession>
    <name>A0A1E3JYZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034129.1">
        <property type="nucleotide sequence ID" value="XM_019173424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYZ2"/>
    <dbReference type="GeneID" id="30190470"/>
    <dbReference type="OrthoDB" id="10439709at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="23386" checksum="1703B483FE1D20AF" modified="2017-01-18" version="1">MSQIHSKFCSPRATAPTIPYDISSLDPLPIEIQNVVYDKLLADPNLTFTLASLSKSHYTTLIPRLYERVEVTEQAVERGLFEDLLTGADRLEARGEGCLPSKRDLLENCKSLVVASLPAFDAITDAIQAWKALLAERRETGTVPDELDGIFNGVTHLAWGPTSSTPCAETKPKWTRTGSILETGITDVACRSRTFTTSVCVSPILSPRRHVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ85</accession>
    <name>A0A1E3JZ85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034324.1">
        <property type="nucleotide sequence ID" value="XM_019173619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ85"/>
    <dbReference type="GeneID" id="30190669"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF5">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="106807" checksum="C6B9732BD6ACA7D0" modified="2017-01-18" version="1">MLPTARKAYTRHASAAVQLWSQALPAESSRQALLRARRVHSHAVAAVEEQSQPSAVESKRDSYIQFKEKEWGRSGGLAAGDEYNPYAHLPAKTSKTSNVPSEWLDSWLNLHDVSALPPSPLPLLETFRGLTPTHPILALLTLPKLSHNDIIALTHNDVRQLLARSTEVAASTPAVLHRVKTEDSAKALRVLRAIIYSLPSPGSTSDPMMGRYLRGKCLRQLINLCYRLRCPALAKSIFQERLREQLATECSPSIVPFKDIAIDLARTRDWKSIVKLFSPETFPHRYYTGRLVELYMQAHLGIRQSSKVPTIFELHDVLSLEPTVTAVNHLIQAYMEMGDLPAARAIAADANSGEPRDIATQQLALLKGYRVLGLEENLEKKVLSDIERLQLPLQGALIHALARLRLNVGDIEAAETLLRKLDLRRWGGGEGEGIEGSEHTKTMLFSLAVENEDLDRVRWFWKDFAQTPRTITDEIIKDLLRILIKGEKVDDASAVLQSGLPNSPESALANEWKLPAGVRPGLQSLNFYLGAMAGLHGLSGIETAMSLFHLYRIKPDSASLKIIVDYARASLVHRPYDLAELVSSIMDVSPDLAPNPALLDSLLADAVASMGRHSNRTIAYPSILRSHSEDTFHPTAGLELSPDLYEPLASTITALESAGAQSTARTISSRLRFDAMSNSTISGVPSARIVWNSLLARGFVPDARHIQALMQGYVEIGHMLEAQDVMLLSQQMRIPTTRGMHAVLLAGYGKKRKPMLARRSYEHIKELGETDPNQGLDLSVVTAMVQAYVNCGWYKEAANLCYVDLKNLDATLDEKATIVIAQTLRANGDLRGALKVIEASEMSLGRAGAKIIRGSRQHALKQLAKPDISEDAKQEAEEVVALAQELLKERKTQEGKLKHTWAGLREKTRKRLSSAWTGMAGVKEGAGAGAAREGLRRVVVGNGKGTGIQALRARRARRQAIAKMRQKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG2</accession>
    <name>A0A1E3JZG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034364.1">
        <property type="nucleotide sequence ID" value="XM_019173659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG2"/>
    <dbReference type="GeneID" id="30190709"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="270" mass="29973" checksum="627E7F6F5AE48173" modified="2017-01-18" version="1">MSTLATADLSSDEEDVDFVPAAPKTKRPRKTKGKTKKAKSPGSASDSSSCSSSDGESGDEEEGDEEERIAKKAKLEEKEKDEAEERRRKAREEFEKMKAEAAGPAEVRQAEEEMVGIKRPRWFAGETILETVKLRASDPEAIAYFEKLQNGDEKPVLPAEESVTKPETPLAETSASPVPPAPQAPKPKGPPRRKRQTLEQMSAALDKGKKMTTLEKSQMDWKSHTSSSTKMEDELAANRRSGGYLANRDFLDRVGERKSETYDQQGTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZQ3</accession>
    <name>A0A1E3JZQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CMGC/CDK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_01533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034401.1">
        <property type="nucleotide sequence ID" value="XM_019173696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZQ3"/>
    <dbReference type="GeneID" id="30190746"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="163"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO06301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="758" mass="82620" checksum="DE77D605114C8834" modified="2017-01-18" version="1">MVPSFKYDVPAPYGAEESKYSKDEAPEKDESASKFRPITLKREKVRRSDDTRAASTVSHTAESARPPTPNAPPPPPLSPPPATPPAPPTVPHAPLLHQDKTRPPSPEREEGEYVEPPRDKSHKEKGRGRRKDHEPERFGMRTVKEEEEAYGRVFVGSSTLMGYETGRKLGEGTFGVVTQATERSTGREVALKKITTHNTRDGAHITTLREIKILKSLNHPNVVPLIDMVMSRGNPQNRKVNTEMFMVFPYMDHDLCGLLGNPDFQKRPSVHKSLMKQLLEGMAFIHANNVIHRDIKTANILVDKHYRVMIADFGLARPWTKEADMPPHLAREYTNMVVTRWYRAPELLLGATRYTPAVDLWSIGCILGELYMKRPLLPGGGDREQLAMIVAKCGPLSQETWPGWRSLPGFVDAPGHDWERSPRERHIAEDVTAYGLDRAGANLLGKLLTLNPSQRPTASEALDHPWFWIEPLPINPKTEAPLRLESSHEMSAWHHKQPAAPAQPPPQPVMPPRVAFSQAPQANPYANNPYAAPLSAPVQQPLNNYPHQSQHQPAPNPYQPLTGHASNQSQPGHNAYRPRPAYAQQQAQQGYSQAQPSIQPLATGYGAGPPVSSNVIGAAHAAMGYGNGGGYGGQPGGYDGAVQGGYGQPSLAPLPQNSFPAPPPSGMRAPPGSLPKRPTGPPPGFSLAGGGGGAPRNRPPQNQNFGNGGGGNARNDGSYGYQAQPGHMKREHSNEQFNANKRHKPDMTTGGGGGGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K0B1</accession>
    <name>A0A1E3K0B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034596.1">
        <property type="nucleotide sequence ID" value="XM_019173891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K0B1"/>
    <dbReference type="GeneID" id="30190942"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="161" mass="17808" checksum="34D6F583B2C76D26" modified="2017-01-18" version="1">MVRDSKSYENESLILLPACLLQSARTVDIPQSVLEDLKNFRFKNAKGTTAISIKIVKSSLTMAVDEEFEDQSIEEIAEELPESGPRYVLISHELKHPDGRTSYPIILINWAPPSSPIGLMTLHASALSYFHQVSEVSKVLEVRDGAEGLTTQAVNEKLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1H2</accession>
    <name>A0A1E3K1H2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_01271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034142.1">
        <property type="nucleotide sequence ID" value="XM_019173437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1H2"/>
    <dbReference type="GeneID" id="30190484"/>
    <dbReference type="OrthoDB" id="2594386at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO06042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="119" mass="14064" checksum="81A7EF843CD4EA6B" modified="2017-01-18" version="1">MREAYGEEWWQLDDDEDDYVRRHHDLGLEFNSYGVDAHRLWSANPGARERKKEKTVVEPVKSMSPYLRDILTNAAFLEWLDGEMPPPALYQEDFGRSRYDLCVARVRAVFERNDVDQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K231</accession>
    <name>A0A1E3K231_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034705.1">
        <property type="nucleotide sequence ID" value="XM_019172979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K231"/>
    <dbReference type="GeneID" id="30190020"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01849">
        <property type="entry name" value="YlqF_related_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="264"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="645" mass="71788" checksum="E6D6D54535BB0C37" modified="2017-01-18" version="1">MPRIRKKTSNRQNTRDRAKITKKAAEQKRKNKKAGKKDQTWKSNKKADPGVPNSYPFKDQVLAEIAEEKRRAEEDRIARKEAAKTKKQEEEEVDTPGISSVLRSVMSRNGPLTATSALPVEVEEEDSDIPELIDTALPTLQEALDRADVICEVVDARDVLGGRSAYIEGLVKEAEGRVVLIVNKIDLVPREALQSWLSHLDIPTFLFKSALPPLPPTAGSSKNPGPHFFMEPESVLGRTEFLAAAKKWSQNKKQSTKSAEPLVLALMGLPTVGKTSILKSLLPSTANKSRHLVTPIIPPAQSSKQPQPTTKAPVEVELDVDGVTIKIIDTPGWEPVEDDEDEEEEETEEEEDPEKWDKLEARLAGDLLRRNMGRIDRVKDVFPLVNYIVQRCNHQDLMLAYNIPFFEKGDLQAFLTGLARAHQRIKKHGTPDLEGAGRVLLRDWAYNTFPYYATAPAASSADMEVEEVEKFDMTAVLEKCKGKKDMKKESAKGIVRFKSGDVDTRDIILDDDYTEMAAGSDDGSEDEDEDEDEDSEADLEFDEAVTEEGDEDEAPLLVGSEDGEEVEFDNDVEPSDDDEEAEEESDDEPELPSPPKSTLKSNKRRISEVSLAPKKKAKRVSFAKESKAGKAVKGSKSQKKGSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K327</accession>
    <name>A0A1E3K327_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035055.1">
        <property type="nucleotide sequence ID" value="XM_019173329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K327"/>
    <dbReference type="GeneID" id="30190371"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="605" mass="65140" checksum="D2D78CBFD9086774" modified="2017-01-18" version="1">MASASQSNLAIDADDHKKLSQDVEAGPSDELHYGEQGDEEVLTGVSKVEAAAAVWGPKSQWFLFIGIALSAYIYSLDSNTTWQYLSYATSYVLEHSVSGTISTANAIIIAVGKPLMAKLADVVGRGETFIIVAVLYCIGYIVIATANDVGQIAGGQVIYSFGYTGLQMLQQIVIADMTNLRWRGLVSGLVSAPFIINNFVAAEIATDILPNWRWGYAMFAILVPVSLAPIIVALLWAQNKAKKQMMIKYSRPPITKGWLVTIKDACWEMDFVGLILIAASLALILLPLGLAPSASNGWKTPSMIVMIVIGGLLFPVAMLYEAKVPKKPVVPYRWLKRGPILGACLIGFFDFVSFYLQYTYLYSYVYVTESWSTRDLTYFSSTQSLGLTIFGILGGIIMFSTQRFKWMLFTGLLIRLLGVGLMLHARSANGNTASLVMCQILQGLGGGFAATAIQVSAQAAVAHVDVATVTAMVLLITEVGNSVGSAVAAGIWASYMPGELAKHIPSANATTIASLYGSITQIALYPTDDPVRTGAIAAYQAVMFRLVLGAVIVAIFPPIFCFFLTKDIKLTRAQNAIENKTIGGEKTEEVADEKTASEAGITTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5A9</accession>
    <name>A0A1E3K5A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034909.1">
        <property type="nucleotide sequence ID" value="XM_019173183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5A9"/>
    <dbReference type="GeneID" id="30190224"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000609">
        <property type="entry name" value="CMGC/DYRK/PRP4 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="495"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="827" mass="92180" checksum="EDF65E0FC1D91DB1" modified="2017-01-18" version="1">MSSGIKRPHADDAHSASGRSDRSDRKKPRDWRDAFLDDGAPPRDRDRDHGRRDRDQGRGGYGDRREMNGGRHGGYGGYYDRDRGYDDQRGPSGGHGSTRDREDYREREPSRGEYSRRYGDRNDYRQDSRYDDRQRPREDDPRRQQGQQGQQLRGGPPPTHASRPSPSAPQISVKLPPAAPPQGKAGMDQFFQAEPEEPEPEPEVVEEEQDPAKMLEERRRKREEIMAKFKATGGKPTVPNVVVNEVGGGAESVTSGGTRTGLQTSTGKSLACSDKSLADSPIAATPMLNNLGIQSSNPPSATPTITEQPSLAHTPQGKAFDLAKHPFASNDSAPLPPDAQTPSGVHADMTVSAADYDPTQEALADHEKRQKDLEAVKPDPQNATAREIADGVGEPVTVEDDDSPKEEEWEEVEIEVDDEEDDEFDMFDAFGDDEKQKKKKKVTVRRLKNGGQAGAREEIINKPASTIAPEVVDNVDDADGYYRITPGEIVDDGRYQITISLGKGMFSAVVKAKVLKAVGQERRQDVVGKEVAIKVVRSQESMYISGRKEAQILKKLNDADPDDKKHMLRLDRIFEHRGHLCIVTESLSMNLRDVIKRFGNNVGLNMRAVRAYAHQLFLGLSLMRKCEVVHADIKPDNILASHSTTTLKICDLGSAAEITEGEITPYLVSRFYRAPEIILGLPYDTAIDMWSIGCTLYELFTGKILFPGRSNNHMLLLMMELKGKINHRMIKKASFGTMHFDEAMNFIGLEKDKITGQDTLKTHVINKPTKDLRARLVPSSSEQLKMKDDELKQLLSFVDLLDKCLHLDPAKRITPRDALLHPFMTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5L3</accession>
    <name>A0A1E3K5L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035236.1">
        <property type="nucleotide sequence ID" value="XM_019172294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5L3"/>
    <dbReference type="GeneID" id="30189319"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="48598" checksum="FDAE6D7927F35A23" modified="2017-01-18" version="1">MDNTPRQLFQTPNNVYVLQQPWQFVKELGQGAYGCVSSARNSMTGETCAVKKVTNVFQKKILTKRCLRELRLLHHFRGHKNITCLYDMDIVFDPPGSGQFREVYLYEELMEADLHAIIRSGQPLSDAHFQSFLYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFQPGAVQTDQGQAGFMTEYVATRWYRAPEIMLSFANYTSSIDMWSVGCILAELLGGKPIFKGEDYVDQLNKILNLLGTPTEDTLRRVGSPRAQDYIRSLPIKPRVRFETLYPTASPLALDLLGKLLTFDPAKRFGCQEALEHPYLAVWHDPTDEPLCEVPFDFSFEEEDSVSGMRDFILNEVRSFRHLVRQTTPPPARREQHESHELPPAPVANQHTGAGVGPAFHETANEGADSEEHPGSALEKQLEQGKSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5N8</accession>
    <name>A0A1E3K5N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035256.1">
        <property type="nucleotide sequence ID" value="XM_019172314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5N8"/>
    <dbReference type="GeneID" id="30189342"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33513" checksum="45EAE331A7BE2032" modified="2017-01-18" version="1">MTSRRTNANMTAGIAAAVTASPVIRWLPEWFDKRKGTAGGIMFRGGGVGGMYMPFLFEYLIARLGYQWSLRITAIFTAVIASIAVYFENPRIPISTRAHINCMPMPPFLSTLAMEFHGDLRLNVVLFLPRFSDTPNGAQGAGLLAAFNRMKPPFAMAICSSLGVLLVFTLWGFGGNQGLPVLMPFAICFGLPASGFCSMWFQNAGDIAGPDKEQQSLLSAGWSIARGLGAVAGPTIGSALYRTPSVPGSNRWGSAGSPGLVGLVAASLAGSALVVLVFRYAGNSVKSLRQYNNSEMGQRRPTSEFGVELNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K600</accession>
    <name>A0A1E3K600_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035150.1">
        <property type="nucleotide sequence ID" value="XM_019172208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K600"/>
    <dbReference type="GeneID" id="30189231"/>
    <dbReference type="OrthoDB" id="2564618at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="833" mass="88522" checksum="FA961B29E8EE969E" modified="2017-01-18" version="1">MEQYTSGLFASSPKRSPNKSPTKRRLPPTTPRRHRSSILPSTPSNPSPQKYKSSGGEQSVERSFEGVMKTLRRMGISTPGKGQAVNQSRWSAWSSEDENEPQQEEGEGFWKGRKSSDTTRSTRSKLSFRARKGVPQVWSGNDPASVYEEEEGRKSSDGRSVKSSRSMRSVKSKRERGRKSEDVERPAFDEERVPDVPALPKAMEAPRTPGKKAKLMSGLVRRLGLTPRKKGSSMAPSETMVTPFDPSQAPPLPLPCTPRTQIRPESNLPPPPGIRDDLPLPRKTSLSTLRSALTKKGSATTLRSVRSNHTANTARESNFGASCTSLAGFEMDLDAPPLPPGLPRPREWGSPKTPRRGGGDGKRTPKSSIGQPKLKEETSPSAFLEQMPRRAPETPKREEFGGGEGTPGLVGGDGDVVMGEDVTDESLETTAIITPPAPGPVPDVTQKHPFASSLRSTTAIRSTSPLGNASPYSPFSLNSFSPAQSSTPLTAKAFAQGKERKSSRLGSLLPALGPAPAAVGHGSKPLRTLRSKKSTDALSVSGASVLGMRDVNAMGLPVPPRSATSLGAYSSFDGASTGKKESNKLMKKSKALAGVAVGQTRVSLGSKVVGLDVDGCFGERGNPFESVRVPTPVPSLVAGSHDSPPPSYQFPAPPTSLPAPASTAFAPEAREDEEMLDKSRTSFNDDDIPATAAAMGGGEAGMSFDDGSFYTSEEPSYVEPLPFTFPCPRPTHTPQLSAFPPPSSFSSSSPHTQNKHIPTPSADSLLSLQSLATSESFGSALTHDTGVTAQTARTRGGGVDSWELERYLQEAERGEERDRGGGVGVGGGRGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K607</accession>
    <name>A0A1E3K607_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035129.1">
        <property type="nucleotide sequence ID" value="XM_019173403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K607"/>
    <dbReference type="GeneID" id="30190446"/>
    <dbReference type="OrthoDB" id="2526979at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="712" mass="76064" checksum="FBFA2415D9B22EEB" modified="2017-01-18" version="1">MSKNPAFPPTHTARTQPSRPNSSFASLSKFFKFSKSSSFPDELDSEQDDHASPPDTEEAEDEQALMWDAQIALIEHQPNLAMKLYAKAALPPHASPAACLALGNLLIRGSAVMEATSTLSMERPVSPAASTRAAEKPYATSFWSRFFAPSFSPSPSTSPSPSSANALSPPLSPSAARKKHDLIAAGWHIPREGKRAVRDVEGMGVAGAWFVLGLGWAVERAKERQRVVAAAAAVAAVDEQGEYLVGRKGSSDEEAIVFGSKKGKGKGMQMPLAVESPSTPGLAASSGANTSATDDSIETPREPAGGLFDKVDDVDAELLSVIYELLRPLLRLYRHGHIQSHDPVALPPISLQQLPPALKPRTEMEKGRNVWALGRVVCGKVKELGLVCDRREKGKGSDQVRKAVMVLTDYILAMTCPPFQAAFHFRHIASTSLIGLEVADDLIVQAGKRLKTIVTGTPRDEAGLGGFPFPALTPTPKRAENEKERTASITSLASMLSPPRILHSTKSTASLVALADPEPDNELQSPVPLSSEAKAGGAVETLKRVQVKNGVWDGVEISAGEVDGEVEQGLGLDVPNKTIRAVASSPQLPSLLSVPPSHTNRRRLPFEPSQHDAIMPIDPALAEAERRSALTKNVKCGVCMMKGVNFPECRRCGMTFCGRECRVGEEKAGNGKRHICGAWESRKLLSVPTAAPGRRSGSNGGLATSPRVAKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K666</accession>
    <name>A0A1E3K666_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035283.1">
        <property type="nucleotide sequence ID" value="XM_019172341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K666"/>
    <dbReference type="GeneID" id="30189371"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="222" mass="24954" checksum="DB2005B17CF5E41D" modified="2017-01-18" version="1">MSALQRFLLDPANHDLLAILKGARNGLVYGCKIRFPHALVMTFLFSHKPLPAKIRGIFTATKTHALNLCKFVTIYKTLLLLQKKLNGGKERNLDTLVAGGLGGYWIFGDRTPINEQIVLYVLGRNILALLPRLYSQSTPPAHPFQPLSHPLPSITSPAGNPKPIPPAQVPFTIVATLSWAVAMYMFRHRGERMQPGLSNSMRYLYRDSETWTSLKTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J2</accession>
    <name>A0A1E3K6J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035663.1">
        <property type="nucleotide sequence ID" value="XM_019172721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J2"/>
    <dbReference type="GeneID" id="30189754"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="735"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO08808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="855" mass="92346" checksum="612BAA2814768CAB" modified="2017-01-18" version="1">MSGHYNLKALIKAIRSCKTLADERSVIQKESAAIRTSFKEEDTLARHNNVAKLLYIHMLGYPAHFGQVACLTLVASPRFADKRLGYLGIMLLLDENQEVLTLVTNSLKNDMNHSNVYAVGLALCTFANISSEEMCRDLANEVEKLLGSSNAYIRKKAALCALRIIRRVPDLSDHFTSKAKGLLQDRNHGVLLAGITLITEMCAIDEQICAEFRKATNLLVKHLKNLVSTGYSAEHDVLGIADPFLQTKILRLLRLLGRGDAAASETMNDILAQVATNTDSSKNVGNSILYETVLTVLEIEADSGLRVMAINILGTFLTNRDNNIRYVALNTLNKVVTMDTNAVQRHRTTIVECLRDGDISIRRRALELSYALVNEGNIKLMTRELLTFLELSDNEFKLGLTTEICLAAERYAPNKRWQIDTVLRVLKVAGNFVRDEILSAFIRLTCHTPELQFYTAQRLYAALSADLSQESLTLAAVWVIGEFGDILLQGGTIDDGDEVKQVSDTDLVDLLEHTLNSPYANSLSRQFVLTSLAKLSVRLSESSSTPFPNAGLQDRIAALLASYSSNLELEIQQRAVEFGSLFGMSDVRMGVLERMPPPEIRATIMGTVSERKPVGSTRTDKDMIVDLIGDDSAPNTSGVAGSSGPSTQDLLADIFGSSSEMASPGATATGQAPKSAANDIMSLFDTSATSPPATVAASSGGGSLFDLVSPSSTPAPPSAPSPAPAPVPSAAPAKSQLQSYPAYDKNALKITLTPRVSPTQPGVVQVLAKFTASGGEVIENVNLQVAVPKTQQLQMQAMSNQTVSPGAGETQQMRIHVPVGAAIRLRMRITYTKGGQNIADQQDFSGFPAGLTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6J4</accession>
    <name>A0A1E3K6J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035340.1">
        <property type="nucleotide sequence ID" value="XM_019172398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6J4"/>
    <dbReference type="GeneID" id="30189428"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31523" checksum="744BD9D7E500F0D8" modified="2017-01-18" version="1">MAESPTAPSKQTPPTVHEDYQKGDVHLLSSDNVLFCVDGYRLGKASKVFSDMLSVPRPITSSTSDADAKVDTGIENSSTRAPSTGAPIEMEETSATLQCFLELAALSGNRTFPLSVDETGNLFLFHRKWDLNDKLSRKIVDEFYRVAIYHDPWGWFHLASQWGDVEFAARALHAMGDGKTFLEGRKDVGFWRSLRELGGSWDIIVLEEAFGNPGRYEFVNYRWVSRKKYHYEQTSIFDGLPLNAPWEEVCEVLKERFKAAGGTEEGSVASLEEEEAGQVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6N6</accession>
    <name>A0A1E3K6N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035709.1">
        <property type="nucleotide sequence ID" value="XM_019172767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6N6"/>
    <dbReference type="GeneID" id="30189801"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="345" mass="37525" checksum="E189F2F4D99273FA" modified="2017-01-18" version="1">MSSPAPYWVSTDDWHTAGEPFRIVPTLPAHCHTLGPTVKDRRRNILSSPDHPLDLLRRVLCQEPRGHADMYGGFIVPPNDDGAHLGVLFWHKDGFSTACGHGTLALGFWSIESGLVKAPSDGVTDVVIDVPSGRVTARVTTQGGKPVHADFINVPSYQVVDQLSVHLPSLGKDISLDISWGGALYAFVDSTEFICLKVIETNHDAFVSLGREIKAVLGNKARHRDLELYGVCFYDKLASDESSLTQRNCVVFADGQIDRSPCGSGSAARVALLYAQGQLAEGQVLHHHSIINTVFDGSIVSTEKVNPFSPYPAVIPMVRGSANLMSQSRFYIDSADPTFPGFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6T6</accession>
    <name>A0A1E3K6T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035715.1">
        <property type="nucleotide sequence ID" value="XM_019172773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6T6"/>
    <dbReference type="GeneID" id="30189807"/>
    <dbReference type="OrthoDB" id="2596711at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="680" mass="73579" checksum="52BBCEC239E2E2E1" modified="2017-01-18" version="1">MSLSSQTTLISQPHLHRRASAHHAHPRRRPSHAHARRGSESEGRRALAAGLAMHTLETGKKKKPAEQRPQSQHTSRSDTNLPHLSRTNSMMSNTSHASQTSNNSTVSRPGAKPRRSREQVQILDEQGREIDPDEEEWESGEEAKRGKKSDKKKDRTNASALATSAAMRRTVSDTSANKQEQGDDEGGDQRPPLTQRTTGFAGAVQPLDPQIAAEMPSVEPPVIQNPIKRVASSKSLVGPISAMTSVENTPDSGIITEAPKSEQERLRKAQENSLLSTGLSRDHPEPKEESPSYPFPKMPSPEEPLKPPSPPRPESPLRKEGGQHREREASSLPGSNGTRSRQVSNRNAPSLRHRYSNSSLRSIQSLRAPPHPLNSPTGYRTMRNSTAAYDSPSKNSTDEKRTRVPSMHQPPVPNPQVNFEVAQGKGWDQIPEEEALGSGTSAAGTSRSQSQQPAQPQSHRRSSVASTRSLRSIFAGTLAPPPAPDSSQNSKRLTAHEAASAAAKRPTTNNPVLYHHSLGHPSSAAESCFLISRFLPEKKLQRPSWEVDPDLTEEERAQDPGAKLTNGEYRTAHETLVHTFRHLGSGVQTQKRSLSRNQSYGILPSSLTLSSVAAATGVASHIAQNGVAGASNGVASNGLGSVKGKDGSRFELSSGGLNGMSPFEMSVQRVLNQRPGRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Y1</accession>
    <name>A0A1E3K6Y1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035154.1">
        <property type="nucleotide sequence ID" value="XM_019172212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Y1"/>
    <dbReference type="GeneID" id="30189235"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="581" mass="63745" checksum="3DE3D342F99A02D4" modified="2017-01-18" version="1">MDHAKETPATLAGSAFSKVSLEDSLSSPSAMAPISLLKQSPSSLSSNPPKTPFPGTGTFSNPFIVDYLPSDPLNPYNWPKTKRWGVTMLIGVTALCPPFASVSYSATLGDVVDDFGISRELATAGISLFIAGFGFGPLIWAPLSEIYGRVPAFLFSYPIFTLFNLGTALSHSTAPLMVTRFWAGFFGGVTLTNSGAQIGDMWAVWERAVATSIFALAPFLGPVAGPIVGGYVAEKCGYRWVYWIQFIFAAVMTVLCIIFIPETYAPTILRREAIRLQNVAQEEGRDEHFISKYDIERKSKREIIQIGLHRPFQMLFTEIIVACLSVYGALIYGILYLFFTAFPIVFQQTRHWSIGQSGLAFLGMGVGLMAGVAINPSISAYFYTRSHLIDGRPPPESRLPVCCIGAILAPLGLFWFAWTSAPPVHYIVSIIACIPFGLAFLLIFTSMTNYLIDSYELYAASALAAQAVSRCLFGAIFPLFAKYMYEGMGLHWAGTLVAFLALACTPLPFLFYRYGAFLRRRSRYAPSTSIVVPSSHDEEKGEEKEEEGLSKVRSRGEEGLEPEWARDAGEGAGREKRSVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K716</accession>
    <name>A0A1E3K716_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035734.1">
        <property type="nucleotide sequence ID" value="XM_019172792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K716"/>
    <dbReference type="GeneID" id="30189829"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="15428" checksum="FF2AAED469DA46CF" modified="2017-01-18" version="1">MNKNAESTNASSVANRKSSVYVSGIAPAVNEEQLLQAFVTFGDIIEIKIPHEPHDPKKHRGYAFITFSSAADAQEAIDNYDLNQLPGYQGSDKFLKCSLAQPSKYVDESGRGDRPIWETEEWRAEHGQPKEDGEGNAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8F2</accession>
    <name>A0A1E3K8F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035369.1">
        <property type="nucleotide sequence ID" value="XM_019172427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8F2"/>
    <dbReference type="GeneID" id="30189457"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="55"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="518" mass="56032" checksum="60FD20B54AF39F29" modified="2017-01-18" version="1">MVPKSLSRLPSLRSRGLCAPRDIRLLSTTPSKSTIPKVPLWISGKEVFDSSAGTVTQEHTRTRQDSCEVVVAGEKETSEAARVSREAFQAWRGVSAWERRAILRKVPSLMQERLEEWKRLLLADTVYGEVMLGVDLHNALHLVDGAAETCVCCGSLPPTVDGSLGLVSRVPYGPVLSIPAFNFPLCLAMRSIMYPLACGNTVILRGSSVIPQASAFLGPLFADVGIPEGVLQILNFSEHDSGARTSQLIADDSVRFVNFTGSTKLGRNLARQCGEHLKPSVLELGGKAPALILPSADLELAANNVLFGAFFNSGQICMSTERVIVHQDVAAEFESILKREAEKAKWNGGMELVRPSGVETAQAMAKQAIDSGARIVFSAPESSTDFPNAVRPTIFTDLPSTATILNEESFAPFFTLQTAPDIPSMIRLANSHETGLSSSVFGQGLDAIEVAEKMEMGNVHINGMSPHDQHVLPQGGTKNSGWGRFNGKSAVESFTQMKVIRIDRQRTRYPLSALYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8W0</accession>
    <name>A0A1E3K8W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035812.1">
        <property type="nucleotide sequence ID" value="XM_019172870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8W0"/>
    <dbReference type="GeneID" id="30189909"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="162"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="784" mass="82916" checksum="5E277457A6688F92" modified="2017-01-18" version="1">MDSAPLTLRILQLTPPTLIPSSQPPTSSSIPPIPFPPPTPTHDFAFSPTPNYPPPLGSIYMGSQLACRVALENTHRQRYPVLGVKMMLELQTPTTRTRLGEVIHRKPSMAASALEEERNRVEPVKPGEEDIPELAFGERVELSAETEVKDLGLGVVIAITPLSIKTRIQSPTHPNTLLSPSLRHQTFLEVLMQNTSPTESLLLSTVGLQPIEGLVVDKVSGDALGLEGEELKVGDVRQYLFVLSPISPPSKTEKGEEVSKFPPTHAPGEILPLGRLSISWISGPYHTPGNLLTSMLNRRAPALASLPAAASTAGARDSLKPPGKGPAPGPATPGKLPVHQPLPIPASPSPLRRDPSSSEHPLPVIPSGADNGEETKWTYDLVMLSGRRGLKKENTCPLKFRLSIRSAEVINASLISGKKPTLPKLAIQYLTPLLPPTATHPHPHNSTVPQLAISAPSLPRTPLSHPPPSARSFTPSSAPTALGYTAQGQGSTSRPMTPLRAELKSAVGGFINNGTGSSRPGTPTATSTAVAVADKRESLQPHGSSTRPALSGPSELQGGENVLMGTRAPWPPSPHVAFNSPYRPAAYPAAMGVAAAMSRIGSGQSHTSASGRGREAALAASGGGGEAKVVEVYHMGNSLTFLDVGEGEGEGEGEVREVVDWSSIPPPLLEPAPAPAPDLSAEKAEEGADKSEGENTPIPEIKPSTQEGKKYWEASVEWSWDFMGWDTGVGVLGGLRVLRFADDADHGEKGEVVDGETADRTSGCRGQKGTVEREWDCLGDVWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HD69</accession>
    <name>A0A1E3HD69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000059">
        <property type="protein sequence ID" value="ODN74290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027819.1">
        <property type="nucleotide sequence ID" value="XM_019180190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HD69"/>
    <dbReference type="GeneID" id="30197431"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN74290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="15581" checksum="5485FADEAFFEBFD5" modified="2017-01-18" version="1">MGDQTINAAAPQHPFVDPKRAPGHEDIEEGDGNDNLNQAKNVLRVAMKKRLDHWKVTSENALSLKSICHSSTSPFPSHPSLTGAASLTFTRSSSRRLLKTRSPRLNNFPPLVLKVMSLLTFDEEADERKETGYEKRRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF45</accession>
    <name>A0A1E3HF45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027866.1">
        <property type="nucleotide sequence ID" value="XM_019180140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF45"/>
    <dbReference type="GeneID" id="30197380"/>
    <dbReference type="OrthoDB" id="10515297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="183" mass="19113" checksum="5743DFF969546692" modified="2017-01-18" version="1">MSQPQTPPQSQEQLQLPTYPPPPHESSHHPSSSPSHSPSSPTHSPSSPSPSPSSSSPSESPQQEQQLEQQEQPQAHAGWQRTDLGLQLAVSFLFALHAIFLGAGLVMTWKGRTVPGGRVYNNAGPGFGIIGALLSFPPLIAACRKVQGTESTALGWLAVATAALVLGIVSTVGNMVFSSLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HF96</accession>
    <name>A0A1E3HF96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000056">
        <property type="protein sequence ID" value="ODN74997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027880.1">
        <property type="nucleotide sequence ID" value="XM_019180154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HF96"/>
    <dbReference type="GeneID" id="30197394"/>
    <dbReference type="OrthoDB" id="2577681at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="518" mass="57454" checksum="6B165A1253C656EF" modified="2017-01-18" version="1">MPESHRLPPILSDSPVITTRQMLANFVPENMDYGHISATSTGAPTAHTRKVFRETVDNGVRFVLDPGLNSRLKEALDDAVPLHQLAPDDLAQTFSERQDSLAHKRHEEDEEDEDEETGDEHEGREEGERDEGGQYTIFNEPQLSARMGSVFWEFINFVTLSKIIPIRSCGFWRPSSVPESGAPDWVYVRKREKTVASFAELKLHTVLPAAKVQQLMTEAGKPGGMRIIMSEEEHWANAGSQLWEEFYMYKRASVVILSSYELFIPVQRDPFAPNVVRVGLPIGKTGPVTGYGVGKLTCAELAVACALPCIDPMPSTPFPPLPKLKPETGSTGASRKRLVSSSNIRTADIARQDLALYRKHQLQPPLQTQQQQQQIQQLQPPQLHIQPNQPQPPQPQPPQPQPPQPQQHQDRPLWERVDLFLQMAVVFFLSLSAICLAVGLWRDYKHPTVAGRALSSYAGSGLWIVGGLLSFPGVIAACIRGPGAGLAARRWLAAMMATLLLGMIDAVGNFVVSSRRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HHU1</accession>
    <name>A0A1E3HHU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_08142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027923.1">
        <property type="nucleotide sequence ID" value="XM_019180113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HHU1"/>
    <dbReference type="GeneID" id="30197353"/>
    <dbReference type="OrthoDB" id="637503at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN75685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="34939" checksum="9F0E4D4179E3513D" modified="2017-01-18" version="1">MSDPISPLPSTWDTCDSWVTSLKDTVSSVPLLTGASNYLPWAESLQIALAGVRGCLCLLDETPAAYLPSASTPSPSTTSLPAAIWKHLDTALALVLVRSLHPDLVPLFQSLVLANPSCAARTLWLKLEADYGGRSSYDLWQSVQALNSEPQGSTPVTEFMTARKNKFEAIKAAGYTLDRRFLDNLVVGLGPHLGPTVRGLDFSSLTYDSLYAAVRGVDDSHRLHAALPSSSMALAAVVTPAPSPVPSLASPVPSADFPCDICRSPTHWSPACPERHAPDARARQEASYRARHARRAKIPGQIVKVIEYSRLPALGSIVPPPDKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ11</accession>
    <name>A0A1E3HJ11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol esterase</fullName>
            <ecNumber evidence="6">3.1.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_08123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a sterol ester + H2O = a sterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10100"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:35915"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000053">
        <property type="protein sequence ID" value="ODN76347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027948.1">
        <property type="nucleotide sequence ID" value="XM_019180094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ11"/>
    <dbReference type="GeneID" id="30197334"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000108">
        <property type="entry name" value="Lipid particle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="657" mass="73386" checksum="56923181CDED6408" modified="2017-01-18" version="1">MTSFIPSLPSPLALINATAAIIAPSPISKPQSPLTPTRGAPLSGDANLVPERYLGEKPLDTSIPSAQNTSFNPHPTRLVHSQPSPDPPPVFVRSPPSTLLDAPARAAMSLPNQQTAQAQARAVRGSDLNTPEYEVDEDTAGRKGESAPLLAPQPVYPGGASPSLSRASSTGSNRGILRRIFIDRSNTPSHHLTAPTFPPPSLSTYSPISPAPLTIGAKLNLIFIQSVSIVLSTFFLAAVVAWAMTAEVCKALPKWVWPDRPMKFPWDDEEYWKKEKTVSKDPAFYARQVGMDIEHQTVETEDGYFLKMHRVIDPDAQTHSDGRGGFPVLVLHGLFQSSGSFVTSEDRSLAFWLAREGKYQVYLGNTRGVFDMGHRNFSRNDPRFWDADWTIRELAMYDLPALVEHVCRETGYDKIGFIGHSQGNGLAFISLSLGMCPSLGNKLSVFIALAPAVYAGSLTTGFPFTVLNKVEWPKWKRFFGVLDFIPLMRWAYDYAPAKLFATLGYIMFAFLFRWTDTNWLHRRKTKMFRFTPTPVSSASIFWWCGKGGFADRKCTLDDSLPRWFDDRFPPLSIYHGGRDFLVFADPLLERLEEKEKDVKVIKVTKLDKSEHCDFYWAAEAVEWAYLSFLDDIESTRPRYPDEEDLPAGNNGTETSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJE9</accession>
    <name>A0A1E3HJE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027989.1">
        <property type="nucleotide sequence ID" value="XM_019180042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJE9"/>
    <dbReference type="GeneID" id="30197280"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN76474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="490" mass="53381" checksum="833A700DA78FC526" modified="2017-01-18" version="1">MSTFPQPFTSTVSHWQATNRGKDSLFGHNKDKALPGDVVDYCVVGAGMAGATTAYRLTRPGVEEGKRVVILEAKDVASGASGRNGGHCAPYSFAALHNYLTPQAQGGVGLDMEEALEALDLERRVLIELREIVEREGWGEKVDFWSGEKVEVRVTPEGAEKMDKLYALWSSARAASRFKDIPLEWSWTHDPATAQATTRMKNAQGFSKGPAGSLHPHKLTTAFLKSALSSPTSNAELYSWAPVQKISKEDGLWVVDCEERGTVKAKNVILCTNAHTPNLFKGSDIDKFLTPFQGQAANVTPPPSYSGSKALDNTYTTDNGTYLINTTHAGIVHGLYQKTSLGKGLMERKDVWGNVDDSVVHPAARKWLAEYCANNFEGWEETAPGEGGMRFWSGIMCATQDTLPLVGQVPKEQVPGGDSQGLYIAAGFHGHGMGRIVLVTKYLVDYIISSKEGEGQWDGGFPKSYVISQERLERGNAVEGYLDEGSNRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLR6</accession>
    <name>A0A1E3HLR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_08038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028010.1">
        <property type="nucleotide sequence ID" value="XM_019180011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLR6"/>
    <dbReference type="GeneID" id="30197249"/>
    <dbReference type="OrthoDB" id="10298493at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN77303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="442" mass="49877" checksum="EDF047D41E6B266A" modified="2017-01-18" version="1">MSSNPETGDVKSEIIITTILLEGSYPTLVSTDGASGRDLQRQVEHPLIERRLTLRSSSTNENGEEVLASPAHETVVAMGQFMARVFRVCDERQYESPLPILPQWRDPSGRFRQYTNESFARHQNHLSEAMQNEYASRDSWPFTYRVHSDVEDYLKDGGQLTGPGDMPRRPREYADRSRRAVKSAKSFDELCAVAPDTVKIAFTTDVLEPFKLMRASSSRSGEEDDGRSLDDWAISDVKPSVECRITDDSPEWVKSDKRVQDAYINSIFESIDKSFTPEPAPLSRDRTADDFVQDTQRYEHILFEEAAFDVAHQLSFTSDQERTNEEEVLRGGETGDASSEVGQPVDGHLVNVAWLEPSMFELFCGLPPKERRFYSKRLVEYETSIKEGLAAMKNERDHQVTGTGDAVSSGKKTWGTWPQRQEDLSEAVGAPDVAFARIELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HPA6</accession>
    <name>A0A1E3HPA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028074.1">
        <property type="nucleotide sequence ID" value="XM_019179952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HPA6"/>
    <dbReference type="GeneID" id="30197190"/>
    <dbReference type="OrthoDB" id="10446094at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13337" checksum="01BA53120D4EA9D8" modified="2017-01-18" version="1">MSEAYQKDANPIDPSVEDDRSNPAEDGRSADADPNKETEPDDPFLNGRTSGPSFPPCYGLSYIKNGAPGGQNSETGAHYLELGKYNGNEWASTWGDAPGLKIDSEWSASDMRTQLDMYMRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUP6</accession>
    <name>A0A1E3HUP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000045">
        <property type="protein sequence ID" value="ODN80068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028163.1">
        <property type="nucleotide sequence ID" value="XM_019179859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUP6"/>
    <dbReference type="GeneID" id="30197089"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000067">
        <property type="entry name" value="Endopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129413" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="104"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN80068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="450" mass="48160" checksum="30D91C580DEE3FD1" modified="2017-01-18" version="1">MLLLTALLPCLLLASAHPHHTRSHAPRSAHGEVSAHPSIDLTLLPTRQFSECLEDRQEWLHEQTDTLLHKYAALIDDSWKKNTSLVKKDVGVAQLTDVNYDASYLGTVHIGTPPQELLLVLDTGSADLWAAGTDCANCGDGERFNPSASSTYQASSGTFSITYGSGSASGDLGTDVVELANFTVPNTTLAVVDQASSGLISAPLSGIMGLAFSRLSNARATPWWETLVNAGRWDSPEFGVYLARYRNDPSASTVEGDGGAITFGGIDTTKFAGELNYVPINDSARDYWRIPLEGLTINNHTPLNPFLPQSSTSNRPQAGIDTGTTLIGAPPSTVQAIYAQIPGSSPLPPWIIDGQGLWQYPCSQNVSALFQFGGQQYSMSNTDMNLGPFTSDSSMCTGAFFEMQMSPNSPIQWIVGASFLKNVYTSFRNTPTAIGFAPLVLNAASNNTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I150</accession>
    <name>A0A1E3I150_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Preautophagosomal structure membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028285.1">
        <property type="nucleotide sequence ID" value="XM_019179738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I150"/>
    <dbReference type="GeneID" id="30196961"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 11" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN82330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="96" mass="10934" checksum="4115BADF38132619" modified="2017-01-18" version="1">MRWMNTRRRIQRRASAIVVRFKSIGAAPIMKNNVFKATAGHKFQAVIMFLRQQLGTKKEDSLFTYINAAFAPAPDDTVGNLYKAFGTEGHLIVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5F3</accession>
    <name>A0A1E3I5F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028344.1">
        <property type="nucleotide sequence ID" value="XM_019179656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5F3"/>
    <dbReference type="GeneID" id="30196879"/>
    <dbReference type="OrthoDB" id="2576593at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="249" mass="27134" checksum="6CAB5B2C0F575A96" modified="2017-01-18" version="1">MSDKKQNSPVPHILAILLTLISTVFLVLVVLYNVPLSSSDRSNLSGRMWLLTVKPATSSTFSSSSGGDSYGFGIWGWCSWSDGGHGDCTNDSFWKITSATEDVGSLGLPKSIAQSMSTAAFLLTFNLVTTIFLLCDLLYTIHFHSHAQPRIIAPLKLLPPKKIKMRTWHAQVLRNLWACCLAVVFLLAWSLPVIVIVGVGAGDVDGSWRGKIGVGWIFTLIATILLIAVRVLLLMGGLWNNPSHSGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5M6</accession>
    <name>A0A1E3I5M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-aminobutyrate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028385.1">
        <property type="nucleotide sequence ID" value="XM_019179617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5M6"/>
    <dbReference type="GeneID" id="30196838"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="479" mass="52001" checksum="7A9F55DFE42ECC8E" modified="2017-01-18" version="1">MPAFRPSPSHLAVLRSTATKPLPLTTSTVGLQAIAEKHITKGLGRLRDHVVKEGQGLRVLTTENRKLLDFTSGIGVTSLGHSHPDVTEAIIAQAQSIIHVQCAIGLSEPYVQLVESLLPMMPDKSLDSFFFWNSGSEAIEAAIKVARTKTKRNNIIVMQGGYHGRTSGAAALTRSKTSFFKGTGPLMPCVYTTPFPYWHALNLPKTTSEEALVEHAIIGLESLLQQQTAPEDTAAIFLEPVIGEGGYVPAPVEYVRHLREVCDKHGIMLVVDEIQTGFGRTGKTFAIEHSDVTPDIMVYAKGFANGMPISGIVTRKEIMDVMLPGSLGGTYSGNVVACAAALATTRYMRSHDILGNVQARSEQIFKGLREIQADEENGGWFIEEVRGKGLMIALEFKSPSSRLTSTPHPSYPEATIPPNLHTLVQNACYDRGLLVLTTSIYPVLRLIPALVLSEEEVNEALATIREAVNEVARGVEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I619</accession>
    <name>A0A1E3I619_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028403.1">
        <property type="nucleotide sequence ID" value="XM_019179635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I619"/>
    <dbReference type="GeneID" id="30196858"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="29"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="527" mass="56963" checksum="4C85483D763229BB" modified="2017-01-18" version="1">MTRTDERTPLLKQPIVDPLALSPTRKRLIVITAMLTGFLSTLDLTIVATCIATISSELKSSDQEAWIGTAYLWSNVTFTPLYGRLSDLLGRRGAYLQALVLFTVGTFFCGCAPSFGWLVLARFVAGMGGGGMGTVSSVLMADIFTPAERGFYQGISFAVFGAGTGLGGPIGGILTQAFGWRAAFYAQVPIAILSIFLAFLTVPNFNHEPFDWRHLKQIDFGGSLSLLISIGALLQLLSRTGGSSSLADDPFGIAMAVICPLFFLIFIFVELKLASKPVLPLSLLSRRTPLCVGIIASAIAVVNYNQMYHLPMVFEIVFKQPVSLAGAHLLPNSLAMTISAPIMGYIVKTSGRYKWLTVLNCAGPVVAMTLLTRLTPESSWASQWLSVLPMGAGFTAMLNSVERHEIATSTGFVFVWRSLGQVLGVGLSSAVFQGSLSNQLSQRFSNPAIIDKLRHASHSIAELPEKWQRVQAREAYGISLRNTFLFGLGGAVLVFVTSLFIPDDVIHDPKTPVPIAPIPDEDFDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9H5</accession>
    <name>A0A1E3I9H5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028452.1">
        <property type="nucleotide sequence ID" value="XM_019179595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9H5"/>
    <dbReference type="GeneID" id="30196815"/>
    <dbReference type="OrthoDB" id="10473783at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="329" mass="35166" checksum="2475FE43505F0287" modified="2017-01-18" version="1">MIPTETPTTSPTPAPSPSPATPMTPPATSPLPPLFTFKRWGSSSRKSKRARSEDVDPFSGTAGGEDDVLRRSVSIDDGMEVEDDGLWEDDGLRKKGRRLSIPAARPLVRARSSKAKLKKVESLSSSSSTSLELARTISPDSPEPAAKRARQRSSSTSSTSSMPGLTGVLFEGKTPSSPSTSPEAPVDATMPLPARPPTRPPQIFSYIPSPLATAPVMSPTLSPPTPSSPAPPQLDLPLSVPLPLPVSPREDAEVIVATAQVTKSKAFWRDVEDLGAELGNVLKLGFGRGMNRGAGGQRKPSRLRSSLIVDEEAAREEERRERYGRMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA49</accession>
    <name>A0A1E3IA49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent Clp protease ATP-binding subunit ClpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028478.1">
        <property type="nucleotide sequence ID" value="XM_019179532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA49"/>
    <dbReference type="GeneID" id="30196749"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="118"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="521"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="695"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="841" mass="92382" checksum="F039603DADB22CB5" modified="2017-01-18" version="1">MLARKHLIRTARIPSIPPPAIRAARLVRPSLPSLSLAAPHPAPALARGYASQPPGGGGPGGFGGMRFPGGQAQGPEKGETLRQFSQDLTELANEGKLDPVIGRDEEIKRTIQILSRRTKSNPVLLGLPGVGKTAILEGLATRIVNREVPESLHGKRLLALDLAALMAGTGVRGEFESRFKALLKDIEAEEGNVIVFIDELHTLLNLGKAEGSLDAGNMIKPALARGLQLVGATTLDEYKKYIEQDAALQRRFQPISVDEPSVESTISILRGLKSKFEVHFGVQIADSALVTAAVYSDRYISDRFLPDKAIDLVDEASSALKLAQESRPAELEKLDREIVTLEIERESLKNEDDPFSASRLEKVEEELETKKEEQKRLADLWSQERERVGEIKEIKEQIEQANVDLEMSQRNGEFERASRLRFSTIPQLQSRLPKAQAELVTENEAEPGMAVKDRVTSEDIAIVVGKATGIPVNNLLKGERERLIHMEDSLKKRVVGQDQVVHSVADAIRLSRAGLQSPTRPLASFLFLGPTGVGKTELTKSLAEFLFADEQRALIQLNMSEFHDKHTVSRLIGSPAGYVGHGEPSQLCDAVRRKPYAVVVFDEIEKAHPDVANVLLQILDEGCLTDGQGKQVNFKNTIICLTSNLGSEALYEPDACHPDGSITETTRTNVLDHVGRFFRPELINRLDELLIFNKLPPSIIIDIVDLRLREVQKRLEDRRITLDVGDDVKAWLARKGYSEHFGARAVARVVRDVVTNKVAGKLLDGSIGDGEIIKLALGGEITSRPDPHLLHPAAESSASAEGTGPRNPPTDPENEARTLEILEDGVEEDGDEEKPRRTVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IA54</accession>
    <name>A0A1E3IA54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha 1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028505.1">
        <property type="nucleotide sequence ID" value="XM_019179559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IA54"/>
    <dbReference type="GeneID" id="30196778"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="60957" checksum="DEE820EA09C77234" modified="2017-01-18" version="1">MPTGSYAPLPSTPTTTTRSSSPSSPTSYRPSLMPIPFTHRLKARNTQVALLAVVLLLVTLPFAHYNREKVQDYWAADYITTDASTQHVPVASGGLANIPLTLEARIQYLLTRPALAQWEAELPSRHGCPFYTYSRNTYFFHDGKPEQWEQIGPNDIVRYRAKIVDYFREVEREGGKLIWDQSMEAEAKQDRRGIIFTGGEGKTLERLKLSLHMLKNVIKSTLPVQVYHFPDELQDPDSRAVLEAFGVELVVASEKRPDGKSWHIKNAAFLATRFTEFVYMDSDNIPLNDPRELFDSVEYKQSGSVFWADLNKDHPDNAIFRIVGKSCTDDHWPAETGQIVFSKRANNGLNLAILHLSNHMMSNPDMYGFLSYGDKDTFRYSFYALGLPYQQAPKIFATAGGYQTQNGEDSDKFCGHSMIQWGLTPWTERHNPSYHPKPAFLHTILGKHRYNLQPSKLFSHIHRPRLDGINEPLLVRTPYDFTGDCFALTLKGPDGAPGAVNSMGDGQGVETVAMGDVIGDDNLWGELKGLSKTFVHINHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IAM1</accession>
    <name>A0A1E3IAM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028511.1">
        <property type="nucleotide sequence ID" value="XM_019179473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IAM1"/>
    <dbReference type="GeneID" id="30196689"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="110"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="558" mass="61912" checksum="EF04C798389E72E5" modified="2017-01-18" version="1">MPFIPPYLCDSLPPSAVPIDPPPTRPQPAPSRHERRPDAHLPFPPSHARGKATSSSLGLGLPSISTNVSDLLLSSLLPPDLPKIPSGGRPSGVGVGTGGPRELTTQREGLSVPVLSNNFRRFVTRVGPIFWLQDRVEEVVFWRKPVWTWGWMLAWAFICFQPRVLLLLPSLGLLVLLLHIHERNHPLPSLLGIIAPAPLATTRVEQQGSEKGEDSPGRLAYTSTTTRDESGEVIGVPAVPPKEAESGVDYYMNIQAIQNLMGLVSDAYDYIAPRFNVIQHPSQNTSPTSLPFTHTHLILLLLPPTLILPLTPPQLLPYLLLPLGLLPPLVFHPNLTPWLLALPHDRRVRRVRDLVEHWLLTDRLPDTFSGKTISQVCVWENERLDPKLPAPGPIPPTAWSSRYLRQGDRQAWIKSSEPALNLESSAEDKEGAGCLWKSTETTLSPEADEGVEAQVLALKPGWEWVPGEEWRVDMSGEWSGFGIDDEGWSYTDDSWQNASPTPYTEADVPNTNTSSSASAFANASAYGSLSLGRDMPNLGLRRVTRRRRWWKRVYRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IDL8</accession>
    <name>A0A1E3IDL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000031">
        <property type="protein sequence ID" value="ODN86588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028771.1">
        <property type="nucleotide sequence ID" value="XM_019179290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IDL8"/>
    <dbReference type="GeneID" id="30196493"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN86588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41755" checksum="FE0A83F85A3A571E" modified="2017-01-18" version="1">MTDADPPKLPYLPEDVLLIILELVEPTASPSTLASLARVSRSLHQKFIPLLYKSITLTQHNCSAFFYGLSSADTISEDERDEWWEGELEDKKSAVARRLAMLGYVQNLRLEDFDAITICHSAIATFLSLELKAPPKSWYDPKKPTDDTRSRRLLFHNRIPTNVHLSSNLLDSLRTSEVPLNTKTWWNQLLQRMLRNSGVLSIEQPEGPAMPYVSRCLEPICRQVCPRLLVLDNVEEAGLGRMLSASQRGVAIRFRDVVDVDSRINGQHFEAMDLISIHMRRTPKPLYYIIYNVSSKGVPVSLGVTTHKGVPVPISEERIRISIVSYAFGIAGQNRRQRRVKLKVVMAGVESEVSVDKMRNDLVEFMKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGM0</accession>
    <name>A0A1E3IGM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NAD-dependent histone deacetylase SIR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_06970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029083.1">
        <property type="nucleotide sequence ID" value="XM_019178989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGM0"/>
    <dbReference type="GeneID" id="30196181"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN87740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="599" mass="66559" checksum="B52C578C9D5AA8FE" modified="2017-01-18" version="1">MSEGSTETPQVKPADTYQIDSDEYDSDQARDELSEVEYDKLVEEAENGYNSEEMDDFTHQLKETGIVNFLRSYLVPDASGEMRSLRKLLLGFGIIPPLPLCTPSTSNLALLPFAKVTLSRILRRRSRLPDLFSLSDALDLLKNAKKIIVLSGAGISTSCGIPDFRSSTGLYAQLQNEGKYELDDPQQMFDIRYFREKPEVFYSFAKQIYPSNFVPSPCHRWIKMLEDRGVLLRNYTQNIDTLESLAGVSKVLQCHGSFKTASCLRCKTRHPGRFIEPHIMAQTIPYCEPCKAQCAQEHAVRKTYKEQLKKLKAKANGKGKGKASAWEQEESGDESGDEWGGGEPGIIKPDITFFGQALDSEFDECLFKDREEVDLLVVIGTSLKVAPVSEVLTHIPHSVPQIFINLTPAYHVQPDISLLGDADSIVTYISDRLGWSIPSPSALPAPKSEAEDAKRRVERESPTPGQKDEEKMKKASHVSIPPEEAEWLEVDDERHFHLLRRKGDPLLTRPLVDVSDEDPSTSPSVQAETNGPSSVPPSVPTSVPTSVPFSQAAAEDAIMSSLGHVPTALGNDIEEGYASDEESEGEERPVKKMKRQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJH4</accession>
    <name>A0A1E3IJH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029322.1">
        <property type="nucleotide sequence ID" value="XM_019178621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJH4"/>
    <dbReference type="GeneID" id="30195778"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="173"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="573" mass="62619" checksum="384EBA0C56D0388D" modified="2017-01-18" version="1">MAALARALPAPIRQTEWEDVFPASSLPTAPQGPQLPKYGARKGWKPKTAADFNGGGAYPECHVAQYPLDMGRKAKGAGSTLALQVDSDGLVRYDAIAQHGRAAGSKVQSSFKDLVPLANRTDVSESDRQMERPDNASVNETAERTRLALERITHGKIKAAQPKHVPKTNSDATYVRYTPANQSAGEGKQRVIKMTEVQEDPLEPPRFKHKKIPRAPDEPPAPVLQSPPRAATAQDQKDWMIPPCISNWKNNKGYTIPLDKRLAADGRGLQDIHINDNFAKLSEALYIADNHIRDEVRERANMQKLLAQKQKTAQEEELRLAAQRAREGRSGITTPSIASGSKPPASLGMGLGGYGSGSESEEESEEEDEEEEDDEAIKERNLVRAEKKREREKEMRLSNMGSEARAKLLAKEANRDISEKIALGLAKPSASKETLLDSRLFNREALSTSFAAEDSYNLYDKPLFAGSSAAAAIYKPVGASHGNDESFGGGTEDGIKEEMSKDRFALGNATRGFEGADKADAREGPVLFEKDKVIALDGSSDPFGVEQFMDAARKGGKRQADDTDGARKRQRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKM8</accession>
    <name>A0A1E3IKM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">L198_06472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029438.1">
        <property type="nucleotide sequence ID" value="XM_019178531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKM8"/>
    <dbReference type="GeneID" id="30195684"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="360"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="627" mass="70292" checksum="AFE796B675DCC537" modified="2017-01-18" version="1">MAKIKRRGESGAAKNYVTRNQALKKLQISLSDFRRLCILKGIYPREPLNKKRANKGSSAPASFYYHKDIQYLLHEPLLVKFREHKAFAKKLARAVGRQEWGLAKNLEDAKPVARLDHLVKERYPTFTLALQDLQDPLNLVHLFSTLPTNPVPGKTLVPAEVIAECGRLISEWKVWAIRTNSLRKIFLGVKGIYYECEVPGQGGETVNVRWLEGHEFQQHVPHDVDFRILLTFLDLYRTMTGFVLYKLYTEENLVYPPPLDVSLDEQGESVGAFKLVEKKNNEGAEGKGVSKKAVRKAIKGIKASGDADVAMDDDAESDDEESVEEDFVERPNKDAATDVASAPLTTYNSLLATSSSSTLPKNLLFSPYTFYLSRETSSRTWEFVIRAMGGRVVTSLSAPSPSEAPQADAITHVIIDRPITAERMREMEGGRKWIWVQPQWVADAVNKHKIISTEGYHPGQELPPHLSPWDGEGELDRPWLEKTEEGAEAEEEEDVEQDAEESDDEDEIVAESSSPYPPALLAAAQNPSNSTYLHAAELEAEANGVSHADFRAQLKEATKLAKKSGGEKKVAGGKKGEEDLRKIMMSNKKSKLYEKMQYSNKEKAAEKENLDKKRKAIEKRKAKESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM24</accession>
    <name>A0A1E3IM24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029541.1">
        <property type="nucleotide sequence ID" value="XM_019178385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM24"/>
    <dbReference type="GeneID" id="30195531"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="653"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="767" mass="82184" checksum="6A0BF0F819DA2142" modified="2017-01-18" version="1">MSSQPPPNGAIPATKPNLITQGLPKIIFAGKTGRILCVADIRGDYHELNRLIKEHDATAVIHTGDFGFMTAESVDRMSDKILRHLIQYSPLLPPATRNQLLSIPPPAGRTALINQLNNSSVHFPLSQFPHLISGAINFPVPVFTTWGLVEDVKVIEKFRTGEYEVQNLAMLDEATSRLVEVGGVKLRLLGLGGTVAQHKLFDYGEGHGSIAGGQGTMWTTALQIGELIDTAQRSFSPDETRLFISTAAPSKDGLMKLVSNAVRADMTVSCGLHFRYPVSYNEFSVSPDFDCYRKKLQEAKDEFKGLFEQVREKVFSALGDKQTALLHKTLSAIENVPLSDDGMWINTWHWSLCDVGFGNMVLSIADSRISSETKSSGANFSHRIGRGPVPPTGAAQTSIAPNPTSAIKAISSRSNQAGPGGPIRPPLNAGPGPVNGVAQSHGRLSSGPGGGPGGFQARPPHTVRGQRGNFGLPVAPNAANISQSNMFSQARASGQAEGKTAAGVPFDTVKKEDVSTTPQKGDHKEEAKEKKDDEKPKTKGEKKADRKKEEKEKGRAAAQEKEKEQKDPKKDDKEANPWGSDKTASSPAAALATVSTSTEQSKEPQSSPWADDDSENKAPEDKSPWEVDGDEKSKDGQQQDKGAFPDDSRPKRWSLLIKGLPSPASIEEVKGAFGEESGKITNVKFIIDPVTKKNRDFAYIDFASEEAMVAALEKSPTSLRDNPVIVSVAPAPKFTRGPFGGRGGFRGGRGFRRGGGSRGGSAGGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM70</accession>
    <name>A0A1E3IM70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029606.1">
        <property type="nucleotide sequence ID" value="XM_019178450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM70"/>
    <dbReference type="GeneID" id="30195600"/>
    <dbReference type="OrthoDB" id="2576380at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129836" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="53370" checksum="08B9889BE3BE5782" modified="2017-01-18" version="1">MFKVKSGLIVPSLMLVLALLAEPAFGSDQRERGALHHARNLAGRQEVENAATAVSSGSGGIASATISQVAETVVATSTGSSGSVIESSSVSVSQTSAVASVLASDSTVASLTSAPGSSASSTAYEIALASSIVSLAQPVSNCTSPGGGCVIFITSIADCSNDTCACDLSYPAQVCAQCIASQEAVDSYNDYLESCEAGGLVEPESTVEVEVDDCETESGEETMVGSTTSLGDVSLTGSAIAATMTNLENASAASGSASRSTALTSSGADSPIALEIGNDSSDTNSSVTGTNVSSDTSALDGVMALATDSPSDTDDDLVTTSYSTISPHAAMTVSSSLGVVGPSATALSGQMSAAQTLSGAIFTQTSQNTSTTAALDSAHAFFSIDIDASCSSDCDSWQQLAQTCTDDTCVCTSEGVSAASNCSSCIRSSSSSNSSSQLASYASFTSNCTSSAYQAGMSGSSGSGMAFGSLTTSASTNPFATGVSRITATPTTSGVNVAEVNGGSTTTVTGGSGFTSEARKIGVSMGSVVSIVAVVGLIGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ING9</accession>
    <name>A0A1E3ING9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029666.1">
        <property type="nucleotide sequence ID" value="XM_019178228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ING9"/>
    <dbReference type="GeneID" id="30195374"/>
    <dbReference type="OrthoDB" id="2577922at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12097" checksum="E2B846FC36A63E3E" modified="2017-01-18" version="1">MPKYPDPDDDTDSMDSDLTSSADAPLEQIMYLLSDQPSIDQANKLHLIGQYLKISGYFKGMSFPPKLIEDYYRSLAPQARDPKQLRASADGAQEAVVPGGGVVWSHGVLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INI8</accession>
    <name>A0A1E3INI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029674.1">
        <property type="nucleotide sequence ID" value="XM_019178236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INI8"/>
    <dbReference type="GeneID" id="30195382"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="209"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="411"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="933"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN90152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116410" checksum="75DD49A9539BAD9D" modified="2017-01-18" version="1">MTSTTDGGAAVSSLVANYEKTLSQVSVKAVGSQLALMTGISIATLLAFSFFRPREKKIKYQLPRPEDLSEDPDYEPPPPPISNGFFAWFSPVLHLKEEAMVANIGLDAATFLRFLRMLRNIFSCVSVLGVALLTINIVYNRKNVDSSNRNALSLTTIADVEGGWMWPAVGASYVINAIVMFFIWRNWQQMVLLRTRWFRSPAYQTKIYSRTLMVSHVRKDFRSDAGLLSLMGLLKVDGIKIGPQIEATCIGRRLQDFPEMVEKHNDAVKDLEKHLVKYLKNGQVGTKRPTVRKGGFLGLGGTKKASPINTEMPVSNIAQDAIDYYAKEIKHLRDKVDAKRAAIDSLIRKERHARENYGFVTFKTIAEAHRIARTHRGKLKELFGASLQLAPMPHDIVWENISKEPAELGSRRTFGWGLIAIICFFNTIPLLVVSILANLSALTVYVTFLESWKDAGNWGNWTFSLVSGILPSAVAAIFGYLLPLVIRRVSKYQGAPTRSRLDRAVIARYFFFMIISNLFIFSLLGVVYAAIARVVVQIGKHQSFSTIIKGFNDIPDQIQGTYVQQSTYWLTWLPLRGFLVIFELIQLIKLALVSIKRFMFSYTPRDIREMTKPPFFEYAIVVVNLLFITAVGLIYAPLAPLVAIGATCVFWFSSVVYKYQLLYVYISRAESGGRTWNVYVNRLLACCVLMQLLMVLTTGLIRSRWLDCIAAAPPVLIIIAFKFYITRTSEHKFRYYKPTVEEQEQEKLALMSGEKKRTKHSDMEKRFLHPALQHNKLFTVMVHKQQESVAREVLSAYPWFAGKHEHDGVEIRAVREENLEYNPDRDGPADEIHQADWDARSVASTDMLSTLGSRSNYPSPGLEDYKQYPLPLVESSPSLHPSVPLDNPSTDRLLMDGSRSEFYGGPQRKASRPYPAPVHNRDVSDLDMADAASPLLGQDPWGGPNQGQGVPYPPSAYTQPPLGYVPPTMRRAASGHSEEDVGVTRWDGGEREHRPALSRETSSDSVGYAVARGGQQGYNSRGYPSSGYGGYEGNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INJ2</accession>
    <name>A0A1E3INJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho guanyl-nucleotide exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029691.1">
        <property type="nucleotide sequence ID" value="XM_019178253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195399"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="619"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="843"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1637"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1678"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1786"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1681"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1711"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1734"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1805"/>
            <end position="1817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1848" mass="204946" checksum="F5524A6D2F3E27F2" modified="2017-01-18" version="1">MGDDSPRSLPLPPGAAQPLPRIPSPAPSQLSEFASVNGTNGLYGSTSRRPLPQPSPSKSSLAPNRYPNRPQGDTEAPRIVSGRRALPTPPAVSNGVVSRSDEAPRSRALPTPPSGPPPPPPPRPPSDHTYMDTRAKPHLPVQPDRAAALRSGGSSSSMSTGQSYRPESERSSIYTSEYAPSDYSRDAGTLPSSVSSHTAAKPPLPKVSIDNADKEWLPILEKFNIPSGEGTLQAPSAAKDPNSGPGTPTQRDWESDYFQQPSGGRDRAASAVTMKAGDDSIYGPLTPRNDDASSVRSSVATPGNASQAMNELWQQDSLKHVETPDSGPSLSSPSVRHVPDPPHRQSSSTSSLHPSITSARSQQSQFPLSPSWTQQTQPPSHWVERKLQIHASHRNSGHSFDDGFEEGPSGGWEEDEWEEGEEEGEEDVDEGRFFQPAFLSEMALQLRDRVERRRHIKSGIAWVGSFTGKDIVTAIQSMLPSHTREGPNDRRFALTLAQSLQNQLWFVEVDWDIKPLRDSPDDVFRFMGEMEGMGSGGDALTTELPKGLMTMATRCYAPSCSGDGRCYAPRCPYRTGPNAFLPRKDTTPLPTPASSIRGVGWKEDLDPITLHGLSPQEITRQDVIRQALASEVAYQADLAAMETLYVNHLRTAEPPIIKDPRDRENFIQDVFHNAGQLREASAALIEEFTIRVREQPVIRFVGDLFLQAATEFRNIYPEYTGKLPQAEAALSKELEENPELRLYIDQVVRENDRRRDLKHLLTRPSSQLQRYPALLEGILNVTNPADADYDFLSQALQSIQSIMSLSQLKLFHASKGRGPAAKIMWFDLVGEEARAEIPKKEQKRQMHIWELVQGEMEYVADLEAIETLFVDGLRTAEPAVIDRNRLDVFLDEAFHNYRSLLEVHSRLLHNLQQRQLEQHPNVGMISDLVFDAALNWQEAYMEYVTHYPIAKAKVQEEEHKNPMFAAFLKTCLKDPASNRQDVYHFINRPIPRLLRYNLLLADILKCLKETKPADDSDIDQIPQVMEVIADLGKATQKGVAVNEAKVELWGFQKTLDGGRFGRKMVDDLDLVNPMRELIHKGKVYRQPEGSITSGWTELSVLLFDHYREASRSSKKDQRQVRSIVNRRPIPLELLSLGSFGDPPRTQRMAGRLFGVGGASHNDASADGSGTDTSKLYPFSISFIGGQERLGGSYTLWTDSYAARQEWQEKLQHAKVLRNEVDDAGKVFEMNPLSVDTFYMPPSYALHKDKEKEFTGRVTCSCPFTTQDGRRLTAVGCQDGVWIGLRGDARSLRKVLHVKAVTNIAVLEDFHVFLVLSDKAVVAYQLEALVPSAGQKPVKSTTERISGPKEEISSFVVGKMADESTNTTRMLVVMMKIEATQTVFKVMEPVAKETVEDAARQRRPFGFSLSAKSDWFRSYKMFYLPAETYGVHFLKKQLAIVCSKGFEIMDLGNLKGGPIPMFDAAKVKEKPALAELESRCSKGRPMGMFRSTETEFLLCYDTFGVFIYRYGEPNRDYRAIEWEGKHDSVAFHPPYILLISAPFIEVRHVNTGKLLQIYTGSDMRLTWDGSGGQRNAPMLKPDKYGYGDETKIQEPQIHIACRASDQKSGKGGQPIGQVVYELSPTLLLNNPLMNPFNTHDSNYLPPPPLTSHVTPQIRQARPPSVRITHSVDQAHNAHGMYQNANPSGFIGSSNAASYAGHPPLQQRPSSLVHRESHHSRDSMSYPESGSYGHGASSQDSAGQFHQSQQSLGVYNSERNHGGGYGGHGQQYSQEYGQYGQQYTQQPAYPGRQASLGPGVPPPQAPQAPQAPQAPQAPQGYGGGYNDSAIRAWAQGGDYRGSNGGYERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP03</accession>
    <name>A0A1E3IP03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019178409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP03"/>
    <dbReference type="GeneID" id="30195556"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="434"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="550"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="434"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="550"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="749" mass="81113" checksum="2F5B6A0127B1023C" modified="2017-01-18" version="1">MNSNTAPGAPHQQWTSVSHDAEGTKKGSSPPLSTGDSPYGYQQQYQQQQGYAALGLGSYPYTPAPTGINSLSNPYNAPRSSPSAPSARRSSSQKIATPPQPPQASPIPSSSARYYGSGPEPHSSPYPSSAPPQTLTHPFSVPGQPPSAHPSYQSYPYEPRHGQWVQYPSGFPHQPKHPSGPSPTVHQSPSLGERPAPAPGYEYPSPAYQQWQGPDAKPPLPMGHWQNGQRLSQSAQPPQQPNAASQSPHAQSSSPMFQQGQWAGYPSMSGVPPHTMGGNGMMGAQPYWMQQQQQPGWQGYYPSASQPAPDGAPAPASTAALTNTALLPRDSSAPAPSTPKTVPKKGSGKEPKKKKEEPAPPPPEAPQVSQEYAGLGKRLSEDGLEEIQDKESGSHSKRKKKKVEVEEQPPEEAFERLERPEKPVARPKSKLHPPKQAPSAWQLFFADELARAKALEPPPDTSPGGTVHPHKFNVANMAKEAGQNYANLSAERKAYYAEKVKIAREQHAKALQAWQATLTPEDVRLENLFRAQQRKEGKSRKGNIKDPNAPKKPLSAYFLFLKAIRENQEIRDQVWGEAVATTKQSILAAEKWRNLTDLEKKPYLEQAELSKQAYEIARKQYEEESAARARGEDIPVRTPIDVTSSPPKPPSSILQTRPPTQMPIQVPLQIPSSPKPSSSHPLSDPVSSIGPLTTPVMATSANPMLSVAPIGISPQEVKPPVAFTDLAPPSPPAGDFKSSIGDVFDFITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP71</accession>
    <name>A0A1E3IP71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029635.1">
        <property type="nucleotide sequence ID" value="XM_019178479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP71"/>
    <dbReference type="GeneID" id="30195632"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="149" mass="16322" checksum="7D93E9F99F365737" modified="2017-01-18" version="1">MSFFRLNILRPALSSSAHLPRAQVFSSSASSRPSLLSLSSASSPLASLRFRQQRLPLGGAVEGMELGGRREFAWSRVVEANPQKQTKLKSHSSSKKRFFANAKGMFKRAQAGKAHLNTPLSSSSINRLAKGVRVTTTQARKLRKLLPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQA5</accession>
    <name>A0A1E3IQA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029881.1">
        <property type="nucleotide sequence ID" value="XM_019178162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQA5"/>
    <dbReference type="GeneID" id="30195308"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="900"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="807"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1139" mass="128097" checksum="5CD6CEA8E2DA782A" modified="2017-01-18" version="1">MSIKGSVQLGSVTIELLSDSALSSPSTWSSLDPLKLQTIKNLASPASGPKVDLLSQAFRDPGLGLQAEWRDIGNGRTARIRCFITPSDVGGSIWKQVLWRGREAVIKGLLNSLTTEWEIEDNGGRTILQLTDEDNHNMQDIYASVPSPTDPAFEPTESPVDQEIHRSLQHYENPEGVKAEMYLYQIRSAAKMLQMETQPKRLIDPLFTPLKEAGADRIYYVNLSNWDIQRHPGWYDLPRGGVLCEQMGTGKTLMCLSLIVATLHQSTQPPTTEIDITPTSTEIAERSYPFTAYSQLRSLTGFPTSRTNFIFPSLVELCANVLSVHDPSSISSPYLPPHLTALLKRNAFYCSLPPPQECVREAKRNAMRRDVKKTYLAKGTLVVVPQILVAQWKGEIEKHVEEGVLNVYEVSGELPPVDKLMEYDVILMDVARFAHEESSRRETHKLPPSVLLQARWKRIILDEGHVAHNKSTNGMLFARQLSIERRWIVSGTPTRHLQQGGEIELESMDTSSPAPSVLTNAQPQSRRAWSKRDMEDATRLGTMIGGFLAAEPFKSEGKFQQLVAAPLRRKEGPAFGAVGRMKYLLGGLLVKHGPKVIDLEAQLPPSTTIKEVIQFDPMQRLTYNVLAALVASNVYTSGGEDADYFLHPRNAESFHQVVTNLHLACFWYSARDMDTFGCLLRTREWLEKHPDRPVHIRERLEEACWHLERAVKEEGWVEWMGNAISMPCDGSLLPSILKEGWSDSFDTKPDMVDIHSLNILRELNVKGASLQGLHMAGWASRVEKCDWYWEVLGKGYTTTQIRELLGDKAPKAARPKKEKKKEDAKKGVTATTTAAQAPREAPKSPSKPRRGKKSDGDEIDSRLDEAGRNARLAEALNDNRPTPLSLSIQTKTRSAKVNFVLRTILAAPEKDKFVIFGNTYELGHLTEGLDMCDVTTCFIGHTLDAKHRRQALDRFESPEVKVCLLDLRLAARGLNLVVANRMIFLAPIWSPDIQAQAIKRVHRIGQTRPTTVQILITEGTFEEDIANRAKSSRSDDEEKMYSRAMIENPRFAYAEKEEEERLEVRFCPKRDWALDREKREKREGPASPPPPAKRRRVMFASPTPLPEPPTNGHVKSEALKKEAEDRPKEPKKKARISFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRU3</accession>
    <name>A0A1E3IRU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029960.1">
        <property type="nucleotide sequence ID" value="XM_019177921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRU3"/>
    <dbReference type="GeneID" id="30195057"/>
    <dbReference type="OrthoDB" id="10381369at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="70157" checksum="4257122BCD19D6DA" modified="2017-01-18" version="1">MATVPQYFRDLYPTSCENAPAPHTIKNKLKHIDKDSYENPVQHLWDHLAQEFIGSLEPLEPFSEHTRKGGDFSAYQNFPLDRIRFEGPQGTTCSYSESSFCEAYTRWRSEYRIDDSQEHNRPDLVFAASRAHEPSTKRDKKRRKTNEPKTFPSQSDQSTHSKTSKFYRDFKLQSNEYLDLILSLVFEVKGRDKLPSEPFLQEAVYLISSYDACGCYLGGFAVGKEFACMMVINKETILFEVPEDTPLTTLGIDDMMDFLADEFTFPHEFSNDTEALDFIWRYFNIAWDAIKDLPLGRRLQRVRQPPWVSREGVRERLTPPLVELGGIHQGLAAFLEHAHGLKPKTATHPEEVTTPSSNVSSGNLDSDPTASRTRSQSPPRKYGSHSGAPSSLTPISDFEHEEEMSNVDDEDGADEEHDDEEHGADQRGVARVGGNGLGLASEMGPQRLLTGKTSEEILKTPIVGNHYSTRDVYDWLSCIPTFTPHDLLSSENYNTLTDKPPSFSKTKGSNNTSEDKSLGVGEVEERPAVMAGGVGFKRKGQSATAGIGEGADFGMMKDEGRAQEEREDRSETVERSESPCRSEDEGGSDILAFHDILLKRNIKFVLTEKSLFRAIVDNVKATPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS51</accession>
    <name>A0A1E3IS51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030079.1">
        <property type="nucleotide sequence ID" value="XM_019178040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS51"/>
    <dbReference type="GeneID" id="30195181"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN91453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="926" mass="103912" checksum="CDE03E9E0680CA31" modified="2017-01-18" version="1">MTELTKENLDNGPASPSSSHGSRAPSLHQPQLSRRSSMSAGHPNSFKQVDTSQIGIPIVTPRKERPSHKRSLTGSYFPSQKGVVDMPGEWPIGDEDTWRKSLADLKIDPDNTQDVATSIVRHINTSLGRQAYNVDEVAAYQATALSVKDQLLERWNNTAAYHTAKAPKRVYYLSIEWLVGRSLDNAVLNLGMRNTYEEADRKLGFNFEDLLNEERDAGLGNGGLGRLAACYIDSMATLNLPGWGYGLRYNYGIFKQLISNTGEQLEAPDPWLDRENPWEIPRIDVSYPIRFYGTSTPIPGTDRSSWTGGMECLAVAYDAPVPGYNTKNCANIRLWSAKPVQGFDLNSFNAGNYEASVAASSEVENITRVLYPNDNMYAGKKLRVMQQYLWVSASLQDILRRFTKLDLPWSALSDYVCIQMNDTHPTLAIPELMRILIDEEEVSYAEAWAITQKVFAYTNHTVLPEALERWQLDLFESLLPRHLEIIYKINFEFMNQVAKRWPGDTDRLRRMSIIEEGTPKYVRMAYLAIVASFKINGVAELHSQLLQATIFKDFVEFKGRDAFTNVTNGITPRRWLLQCNPSLAELCTHTLGSDDWLTNLKLLKQLLPMAENPDFRKAFVSIKKDNKRRLADLVEAELGIILDVDSVFLTQIKRLHEYKRQTLNIFGVIYRYLQIKAASPADRKKFTKHTHIFAAKAAPGYYVAKLVIRLINNVARVVNADPDIGNLLKVVFVPDYSVSIAEILVPASDVSVQISTAGTEASGTSNMKLALNGALLLGTVDGANVEIAEDAGEDQSFLFGYLAEQVDGIRYTNTYQPTPLEQRSNELAQVFKAIENGTFGDGGTYAPLLKTVYEHDYYLVSNDFGSYLSAEKLMDDCFANDPTEWTKKSILTAFNMGDFSSDRSVQDYADGIWSVEPCEVPENFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS82</accession>
    <name>A0A1E3IS82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030065.1">
        <property type="nucleotide sequence ID" value="XM_019178026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS82"/>
    <dbReference type="GeneID" id="30195167"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12693" checksum="3EFAB2182E81175B" modified="2017-01-18" version="1">MSGVRSVVLFLMRHKIAVTDARSLSKEAKIHTRFVYPDREKGSYSIQNKGDIKWYFISAQEPSDVLLFKQYDSENPGHVVGHTSILDERFDGQPGVVARWNIETRSVVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITZ8</accession>
    <name>A0A1E3ITZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030214.1">
        <property type="nucleotide sequence ID" value="XM_019177830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITZ8"/>
    <dbReference type="GeneID" id="30194964"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="123"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN92080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="464" mass="50969" checksum="B1BC647FC1B8FEF5" modified="2017-01-18" version="1">MSSLTELFQFLDSQNPSARQLALQNLVGHTPKSAPERHIFIPSSFAGSGATGGGLVPNKRKDGTEEDEIKLKALKDLTLLCMDQGTIAHDALSALVNLSDTLAVAKHIAYRDFLVWLVSYTAYTTSPLSPLTSMLLSNITSHPSLIPVLANLTIPLIPLPKSTHYPPYYLPASGSSSSTIHPDFRDPSLGLPPNAEVGQEPEREVEAIRALVQAFEDGASDGVRDAQGKRKGECHFLASVFANISMAPVTRQLLLTPRPPFPQPAEAQPSEDDEPLLSKIVVYTGHPDLIRRGGALGCIKNCAMDRASMVWLLASEDDRVRLPSDPSRMIKGVDVLPWVLAPLMGPEEYDIEDMEKLPPTLQFLPPEKEREKDTVLRMMCVEILLLLATTFTGREALRNRGAYFVVREHHKVETDQQIKDSIERFVGLLQRDEGRESKTDEVEGIVKGGAKTEEGEGELDVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVR4</accession>
    <name>A0A1E3IVR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030337.1">
        <property type="nucleotide sequence ID" value="XM_019177586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVR4"/>
    <dbReference type="GeneID" id="30194717"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="92" mass="10230" checksum="7D5E844E821FE92E" modified="2017-01-18" version="1">MKGMAGKLRKAENIGNSRKTRKGEKTRKGGKGGKGTKGKEVGHEGMGNAGEMKMMCPWTEREENMAVDKFIEILSNYVREQVEASLDFSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW44</accession>
    <name>A0A1E3IW44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030444.1">
        <property type="nucleotide sequence ID" value="XM_019177693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW44"/>
    <dbReference type="GeneID" id="30194826"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129975" evidence="3">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="173" mass="17003" checksum="D9FC5AD9A13454F8" modified="2017-01-18" version="1">MFATKVFAALVAASVVLAAPASQRSGSASGSPTASNSASASGTASASDSGSSSASGTASSSAASSSASLSSGDFSGQATYYTVTGTGSACEVTVTDDDYIVALNQPQYTDSDHCGDTVTITNTENGNTATARVADECPGCDSGSLDMSPGLFGALNDDDYDEGVFAITWSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXR9</accession>
    <name>A0A1E3IXR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_05274</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030515.1">
        <property type="nucleotide sequence ID" value="XM_019177362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXR9"/>
    <dbReference type="GeneID" id="30194487"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN93410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9474" checksum="4D8FAD4F2161CBBF" modified="2017-01-18" version="1">MSSPEPQDATQPATGSPSEFLQNIVGKRVKVRIGSGVDYTGLLTCLDGYMNVALENTEEWAGGVKTADYGDCFLRGNNVLYISALEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYI2</accession>
    <name>A0A1E3IYI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030590.1">
        <property type="nucleotide sequence ID" value="XM_019177437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYI2"/>
    <dbReference type="GeneID" id="30194563"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000187">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="145"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="585"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN93485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="814" mass="90111" checksum="0A27979EBE216580" modified="2017-01-18" version="1">MERTRQQVPQATPKVASRARAIFGPKTPSAKPHPLSSHNSNTHDVPALPHGISPKDGMSSVKLKIKSSTTPEARSRVLVKPMGSKLPGAGSRPVATPSMKLVTKTPQARHEDVFEDQWMSAPADASDAVMPAYDEYQQDLAETEAVQVSIRVRPANDMELRTDSRCVWTMPDHDPHVLKLAKGTEGSREDRDWLFDRILQPHCNNSNAYHTSARTHVRSAMEGYNAVIFAYGQTASGKTHTLTGSPSEPGIIPLAISDLFSQIRSTPDREYLLRASYIELYNETIFDLLHPNHGHELHLSETKKGITINGLTESPVRNEYDVRQLLRSGEEKRRVGATDWNSRSSRSHCVFRFSIESRARSSSGEETPRTPGRGDKTTRSSTLSIIDLAGSEKHTSSKERNAEGRHINQSLLTLKLVISKLADLASKRNVTHIPYRDSKLTRLLQNSLSGDALISVICTVSPSGLNLAESISTLAFAQGLKRVVLKAQKKEVVDPHALIQQYQNEIAELKAQLAAKDAGAGTVGSKASKNEKENNEAMEKRLNELKSMILTSVNVKLPNLGDQAMMPPASPAKMKYPKLDYDRPSAELQEELHAEQLCRAELEDEVARLRAELATRPLEPNAHIVQLQNEVSELKLIADDYERHLLEPSRKVREDVEKEFRSKMKTLENQLDSKKIWANRLDENVRFLSTENKQLKARSVEAEAKVSQIIEWINLALLPPGMATASSADQPLESLVVSDDFSPVPSVNTSAKNTLTLSASKMRATFSQMDLANFNDKFGTLTMGGNGGRGLGSDLVREESHFDLAEVASDDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J026</accession>
    <name>A0A1E3J026_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030758.1">
        <property type="nucleotide sequence ID" value="XM_019177177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J026"/>
    <dbReference type="GeneID" id="30194294"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="489" mass="53793" checksum="9DE935DB1284C4AD" modified="2017-01-18" version="1">MVKETQLYDLLEVQPDATDIQLKKAYRKLAIKYHPDKNPSPEAGERFKEIGEAYQILSDPDTRAFYDKVGKDGMSRPEEGNFDPQEVFSQIFGGAAFFDYIGEIALVKDFTTTMDVVMTEEEKEQMEAAAKADAEAHSEADAPTEKTSAAAAATAATTADPLGQPAAGATKDAAVDEVGEGVQSIALHSGASNAPAPSDKAEIESAQKTESAKKAKAKISPEQKAQLEALEKKQEEEKEKRIKTLQDKLLLRIRPFVDAKHPGDINDQETKVFESRIRIEAEDLKLESFGVEMLHTISQVYITKAGNFLKSKKFFGGGFIGRLKEKGGMMKEGWNLLGSAVGVQTAMAEMERLEAKGDATQEELEALAQEVSGKMLLTTWRATRWEVINVLGVVVDNVLYEQGISKDVAAKRAKAIMCIGGIFKDVQPDESDDERRELERLVMNAGKKKKDEKKDEKEKKGWFGRSSHKHESVVTAEGTEAQETPKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0C5</accession>
    <name>A0A1E3J0C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cerevisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_05194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030868.1">
        <property type="nucleotide sequence ID" value="XM_019177287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0C5"/>
    <dbReference type="GeneID" id="30194407"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130050" evidence="7">
        <location>
            <begin position="17"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="184"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN94337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="508" mass="53097" checksum="278809A936B51A44" modified="2017-01-18" version="1">MRFTAALLLLPLAAIASPIAQPDLAPLQAAPEGNHLDDSYIVVFKKGVNPSQIALHLNDVEQIHGANPLDSFTADGDVEEGGLRHVYSPPGHKAESGFFGYAGKFSLDTLQAIRSAPEVAYVERDQIMTTLEVPRGVDDVEEVSGSSAGITTERGAPWGLARISHREQLHLSTFTKYLYYSEGGEGVTAYVIDTGINVDHVEFEGRARWGKTIPKNDVDKDGNGHGTHCAGTIASKKYGVAKAAEVVAVKVLGSNGSGTMADVVAGVLWAAEQAAKDAEIAAHEVAATGKTKRKGSVANMSLGGGKAQSLDDAVNAAVEAGLHFAVAAGNDNKDACSYSPAAAQKAVTVGASTLGDDRAYFSNHGKCVDIFAPGLNILSTWTGGNETTNTISGTSMASPHICGLLAYLLSIHGTETFTLLESDLEAESTSGIYAKAYAQAWSLLPGLAQSILPAPETELLRPVPKEDLTPAQLKKALIKLATPGVLSDLPSGTPNLLSFNNATLPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D3</accession>
    <name>A0A1E3J1D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030917.1">
        <property type="nucleotide sequence ID" value="XM_019176885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D3"/>
    <dbReference type="GeneID" id="30193990"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN94638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="448" mass="49632" checksum="067F698C921B1E87" modified="2017-01-18" version="1">MSQSPLARSTRKSLPAFAHAPSKLGKSSIKPEDPPSPASPRPWPDRDSTPSKGTPSKSTQSTPRYRNAGFSTSSPHTPKIHYSPHALATPPQSMSKSASIPFDMAASAKAARRAEEEMRRTPMEQSGKKKRFVRRKPLHERIIGFPQKVVDTFLFHTPASVLDVLPEPHLANPIALGVHVLHYLLVAPLFTAKDDYGSVLQSGRSQSAVSSRWHDVENAGKTGLLGVSTRFFLVALLMALALGNALYLFTRFRTYDMLLRNPTEAPVHSPHASPVPAPKAKPQSDDEEDNVFKAELKEPWFPKLLKLTGRALLYLVKFTFHAILSAFGKPTTGPSLKDIGASGHTVQSLRVWDPPPFCLAFFSAYPPTAPILTHLLTPINPLLTPVLHLSTTFLLAHLEQAFSQLVKDRMILSAEVMREYDQRFVYKKIFSNKVDRGVSTHECELFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1D8</accession>
    <name>A0A1E3J1D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030921.1">
        <property type="nucleotide sequence ID" value="XM_019176889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1D8"/>
    <dbReference type="GeneID" id="30193995"/>
    <dbReference type="OrthoDB" id="10337575at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="251" mass="27094" checksum="DB7503AF4F31A591" modified="2017-01-18" version="1">MAMGQWTPTEDPSTLLNPPQTAPPAIPSVKPAPKRKASAPKASSSKTILPSKSMPPPRAPPRHTIIGDLNGDYYPSAGQQAEGSGSSIASGSRTNGLSAYQAAKQKQAEDGEWSDGEDSYGCGFDGDLEIMVNGVPRGQRLAQDSWAVMAQVLQNQPPSSATTLQIRTDAERYYQALVQISKNPGPHQEHPWGDRMHRLLMFYTYVSDVGDKIVCARACNSLGSDFSTRGLRELLGDAEYFETTGSLIRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1S2</accession>
    <name>A0A1E3J1S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="13" type="ORF">L198_04964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031096.1">
        <property type="nucleotide sequence ID" value="XM_019177064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1S2"/>
    <dbReference type="GeneID" id="30194177"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="307"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN94817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="485" mass="54730" checksum="E84DC992CAF080F6" modified="2017-01-18" version="1">MSSPPSLNTLKLSGTSSISPPKQKGMTKLDRSAFDISIDILGVIVEPRDVTKIRALRPVRELLLELPKIRPITDCPPDQIPASCKDSQNLKVLWLNVASFDDIAEETRALLEQYTKGTARDTVAMGYDNFGPTEILEACLPTDKSDDFPSSFTTTGHIGHMNLREEWLPYRFLIGQVILDKNPALRTVVNKLDTIHAQFRYFDMEVIAGETDYLTTANESGCSFTFDFSKVYWNSRLHHEHERLISLFPPQSLVADVMAGVGPFAVPAAKKGCYVMGNDLNPESVKWMRENRLRNKVEPTLRVTEVDGHEFIRIAPLQAWTDPFEPALPPRAPNRKEAREARRKRDEAKAQGLPAPVEQETEPKLPPAPKLISHFVMNLPDSALTFLGNYIGSYSPLLSEPTFVEQYGEAGEEKVELGMVHCYCFTKEIEPEKAEVDILQRASHYLEYDLTPQAQDYNLHHVRSVAPNKDMYCLSFRLPRQVAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2D0</accession>
    <name>A0A1E3J2D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031104.1">
        <property type="nucleotide sequence ID" value="XM_019177072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2D0"/>
    <dbReference type="GeneID" id="30194185"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000135">
        <property type="entry name" value="Peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130075" evidence="3">
        <location>
            <begin position="20"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="132"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="748" mass="77425" checksum="92348C1E5E8EFA64" modified="2017-01-18" version="1">MVHATHFLTILSLLPLSLAVSVSNTTTQPAPNPPFANLALPPAHAARDVLGVAHPSPSTTHSHGIKRNVEKSRGVRAHSPRDLPAIVGDIPAITIGGIDLPLIARSHSGSGLSKRSTDNATLLPLATTENTFIVPVSIGSPPTTYPLQLDLASSDLLLASSLCTSSSCPSSSSTNPYYDVAKSQAGWEEVNGNGTLWNTSYADGTVASGFIGREVITLGESVVQGQVFGVINSTNLTLSDQSISGILGLGFPRLSVMGHVLLRESEAATTLNATPTATDNTTASVTGTSNSSSTSTTSSANATSTDIAYLPTLLENLVRTPHLPYPVFALALAPPINDPSSSASSSAASASSTARYDPSHGSLTLGGVSAFYVDEKEGSGRTVGDIEWFDVVPFGQPLTNNDTTTNDTSAESVTTSDATATATASSSASSMRKRSDESQIDSLPASTTALSQEEYLQWALTLQNISLNGTVITPNSSYASLGLGSVALLDAGFNGIAGPQQDVTRIFSTITDAREVQTGQWVVPCNTKMTIGFSFGGRYIQLQPSDWIYAGVENSELCMAWPIAQEGTGDGIDWQLGTPFLKNVYSIFSYGINGKQAPLVGFLPMEYSSDTSDNSTTTSETSTADPDSPTPTTIEGLSLTTTLRTRLPNAVLASPTFPTPSYAYSSSPYVLQTGALQFMGLGNDTEYEVGDVAVVSVDSSAVSSIAVGGGSSNSDGAVSGAERRVLKSGTGLGVGMIAGGVLLGTMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2M3</accession>
    <name>A0A1E3J2M3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030897.1">
        <property type="nucleotide sequence ID" value="XM_019177316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2M3"/>
    <dbReference type="GeneID" id="30194438"/>
    <dbReference type="OrthoDB" id="2564214at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61509" checksum="B399B825CC9D979B" modified="2017-01-18" version="1">MVFKSASFTDIADALKFGKKHSGAVTPPALTLSLPRAKSSVSLYPETSLELHHTANIRSRKNASGHFPTPILKRILSYCDTPTLRACLTVSRLIFHLAGHLLYSEIELHPKSMQDVLRGSVIVHEAATGMVTGGRKRFKDRLLKRVSEVTVWSHGEDDDDDEPSPPCCPPVTLNYLLPKLDSLRIVLGEAFDYHMTFCPRYPPTCPMFRDLVVEKLVILGARSPMPVLPLAFPHKYYNTPTTPTTPGSVGTGSSVGTTSPNTPLIAVTEGEGEDDHLANDPLLLVPNANPSNVSALYRASANSFLPANSFFPPTGKHHTRTASLAPPAQVLPKIKNGHTRNTSLPKSLSSLPLPSPPATNTTHSPRLPPCQELTIVMPTGLSYDAKDYQPYSHCFRHRKTLLTLERFVLVFYSPPKLGRPWQIAFYNARKDGSSTSYVSLVDDVAGTCLAVPFRTEIEIVGTETMDGELLNMGLNTMRTGKVGKVMQDRLRSRIETKWYAEGMKGDVKDRLRRVRFRTLGEWLEGEGEGVVEGWDLEKWGELGGADYGEGSSDDSEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3A0</accession>
    <name>A0A1E3J3A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031302.1">
        <property type="nucleotide sequence ID" value="XM_019176827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3A0"/>
    <dbReference type="GeneID" id="30193931"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130097" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="11">
        <location>
            <begin position="128"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="278" mass="29852" checksum="EFC5BA404AFF049B" modified="2017-01-18" version="1">MLASPFVLLLLGTSVPLVVSNPLNVLVANGTLNNTQTSSSEAETAVTFSDRPALNISSHHTSNITYISPQVPAPLKATHANPSSKWDEAHDRARSYLSKWTVAEKVSLTTGLGWQQGRLASGVRSTDYVSAFPAGINAAATFDKDLIYSRGYAMGQEFKGKGAHVALGPMTNMGRVAAAGRNWEGFGGDPYLSGWATDATVRGLQDAGVQACVKHFVSNEQERNRTTSSSNIDDRTLREIYTHPFLRAVQAEVASVMCSYNLVNGSWACENPKTTPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4H5</accession>
    <name>A0A1E3J4H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031408.1">
        <property type="nucleotide sequence ID" value="XM_019176480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4H5"/>
    <dbReference type="GeneID" id="30193574"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="107352" checksum="BBF3194318C1AE0B" modified="2017-01-18" version="1">MSDDILRNSAALNALKRHQLVSLSKKYGLRASGKNVEMIGRLQVYADDHAGDLDFYIPEPAPTPARPLPAEYPIPSATSPAPSPDHLPQILLKPKAQLNHKESFMSTASRLSNSWDVLSEGNASLISKMEDVVEEEGEEKYGSMGSWKSANNGEPLNEFGGEAPEHVKRNSSMKAFASSISKRGSLILLGRSDSSSSNRAHGEPGYEPPADPETVQSQPAEEQQEMIVDTPPSPASTVGVPRRHSRHTLQERPSTIRLCSPAPFQATSDSTSDHSNDDLPFVGKARDLKERRSMAPLRSPAGAPSLGAFERKSMPALPYSNSASVGNVYPSLPTMPVEYASLIRSSESASDATPIPGAFPPLPPTPGRAQILFGDRTGTGVSNHQFSEAAQAVLKEMNAKLPQGSFKFGEELLKGRDAELAKLVQVNKDVGTGGWGLSGGGLTQDRYAEAHQKEFAKMRSISKSSIRPGPSRTASSGSVTRPYMIPLAEGSKAAKRKLAGSTSTLELPSAPNGLPLHSAEEDVDSRQSKRTRLSTHPLGSLRGAKKSLANMLGEEKGLSQHTPRKQKDRKEKRASMLGRGNSMKFPFLKKKSTLGPDSLSASSSLPSISHPRALPRTLPSGPETGASNTPLSSSTHKRLVQHSTDNGQSQKDRGRSTSAQTMMSQASGRTPKRSRIPDFVPPLPSAKQDKQASLDATNTLGLPKSSSVVKSTTSFVTNTSSTSAARAYKRQSQMDLLRNARPAPLPPAPVHDLQQKSKASSATSASLDRALSSFVLAPETKPKLPSSFPQTAEEYPRVPSSSSTRSLITPAAPRPQAASNPNRHSTLFQPTAASLARMQATVKPRTDRPLPTLPSTPSAMVQPAIQPTQAKENKRENGDIEVISPSISFNTIQPFGNASSRENAFESNFMSKPSPSNTKGSLNGKSSTGPKTTLMKKGSTASISAVAARNRARSNGLSAVKSRGDLRDKEQDMKRRKEEMKATMERRKEERELRELLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4X3</accession>
    <name>A0A1E3J4X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031574.1">
        <property type="nucleotide sequence ID" value="XM_019176646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4X3"/>
    <dbReference type="GeneID" id="30193741"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="473" mass="53817" checksum="D39C8AB6305EE4CB" modified="2017-01-18" version="1">MEYETITSGRAKRSTAGNRMRELLEKAHQEDDDELFQEVEDDEEFVAPVDQRDVYLDEFADTDDEGSGDDEERALQREERHVKNKEKGKSKALYDPLAKQPKKKKKTAIEGAGEFKQSDLDMLRAEGIDPATMAPSTLTLEIRKRRREMKRQGRSEVRRSNLRASTIKNEAEIIEREKLSLLALEQPGRKGRKSQHTTGIPQPHKRKFTQDELIAEALEEEERNKEALRDWLKKEDEKRMLRKVGRKRVKGPRWTWVSRTVGKLVDEVPEAAKDVEDDPPEGEPSEPQEASKAVTTEAPKAEPEKPPVPILSPSENAPSQYTRNYIILSQIPGGLPAEFGLVLGDHVAWDELKVIPARNRPINRIPPLCPFTGLPARYRHPLTLTPYANAEGYAAIQDLLAERYVWNGEGMCWMGGEEEQWADGMEEVEGWAEAVGLGWRGGEELVKREVELNGKKRGREGEPAPKRGRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Z7</accession>
    <name>A0A1E3J4Z7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031578.1">
        <property type="nucleotide sequence ID" value="XM_019176650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Z7"/>
    <dbReference type="GeneID" id="30193745"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="204" mass="23479" checksum="BD3B499988B72099" modified="2017-01-18" version="1">MNAQDPLGEPFAFWELVKPQRPSPECSDCGKLFSSMKWKIVQHLWADHGVSTAGETNTTNFCHWCREYFVNPHRWEDHCASHHQKVVQPMVEMAQCSAPGDENLKWPHLIEFESSVCSNRGSARFASSRSQLCQVTRSSCGNEGFCVKADPAQIRQILEPRERHWDAHGFDRARRIKDLATDPTLPYQAVQWRLLYKDYFGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J546</accession>
    <name>A0A1E3J546_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031430.1">
        <property type="nucleotide sequence ID" value="XM_019176502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J546"/>
    <dbReference type="GeneID" id="30193596"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7388" checksum="009534F3E67E84A3" modified="2017-01-18" version="1">MSDSAHQNHVISGYKATLNNPNVSDEAKSRASEGIENFQENGSSAIEQSDKNNGNADHHENQVLGGHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J552</accession>
    <name>A0A1E3J552_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031226.1">
        <property type="nucleotide sequence ID" value="XM_019176751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193847"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1467"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1897"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2120"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2675"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2864"/>
            <end position="3041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2691"/>
            <end position="2710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2938"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2955"/>
            <end position="2978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2979"/>
            <end position="2999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3023"/>
            <end position="3035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN95246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3041" mass="339801" checksum="12817AF38E84A9F4" modified="2017-01-18" version="1">MSKGTPCPPPGLIENAMPSFNTIALTLLALLITSFIFRFHILPFLLRSSFPNLRLDYISLLSARGVEWRRPGGDEGAPTVTVERAGFTWGGAKGEVTGLVVLRIEGICLRLKQGSFESGRDKKERVKKQPGRLSSTKTRFISNVLQLLIHHYPSVTRVISVQIINCRIVSEDLNEVEMTVKELGFGVNVDFQGEADLPDSPFSTSHPKHTYKRDHPLHILSPVLSPAASGDESDFITSPTQFSPPASPLNQHSFTMPPSAPSEPSEPTRPKIHRTDHSYSRLSHARRRASVFQSRMSSTASKIWTRAAGRKCGSVCLSAYIDTIRCSEPSPSPPGSAKPSVTDLKPPKSPFGRAFQSKRRPPPITVTIPDAGVEALVAVEERSRVKLSLGFGPKKGLLGEDTLSVDAGMGKLSTTLEAVERIKTLLDRVKKEPAEKKAKTDQWSSHGSARIMLRALESAKVTFSHITFTHYLKNPHLKPSRPVSATSSISELDISGQPGDDRYILALELTDISCTLSAADSSNNDRARNAFGTNFSPASVVRGVGAQISWQKIEFQCVAPGEENHEKSQLLAIRQAEFTGFSSWRPQGWSREEMLFASDPNLALVVCFGKVTSVDLAGDMQLLHELEIAWKATHPKVHKAAKKENSELLIGWLPPRLRMVLDVGSITAVLADRVSKETTTLTFHLDGLHYGTYTSFTDIVARRRDRSAARTAFEQEEQLQERRETNHDVDYAMHPSMLPQAVRRLSTANKAELRDGLSICMRGDATIRVEPIQVNMTLAGDRIYELAEIGRLHGTFTGDVLGRCEVKEDGSESATLDFSSISGRLDMGLQEGITVDLWRREVVEALVIMGEAHQKRPWDERPPPPPPPRPILDILPSGISARVSLGKVNILMGVKDPNPGCHLGLIRGVWFQSVVVLEYAFYKNAIQALPWRHTLTTARRAKLRLPEDITTQALAFAAKYQPGRGGAALVAINTEDTYVQPVFNGKRFVEKGGVKHSKMPKDKPKAKDEDEFVGWAFQRAALRKKLGVNQFANNVRPLDLSDAAQASRPWLRIPTSRTYVTTQQSSQGAETEFKITSKTEGVALISDLSHVYCNLLAGLAIKRMILAWKRPKPPRPASLPPRNPSSLSIDFTIPNFQAHFAFPLDEQIYVYAHSVTLRKKPYTGLIAATDHILAYVPSPRLIGSWEELLRVKTLAVALSDPHLPLVISPTIESIRFRIPFAYKLNNLVLNINVTIKALKLLRNSVSGKTPFTTVSRPAAEMPKRIPMVSISIGYMSLEAKDDPVETSLNLIWRAGMVEQTKRNLLEDQFAKKLLLISDPEVQPDVQDEAKNTGGRRVPVLTKKHTVSAERARWALDTLITQSWTRRIRAAKHEQARRENVALQPMMGCGTSTKLPIKIAASSKTAPLFRAAFQDVSFVVADPGLVREEIIDYMGKVSSPFRSDAEFSLMVPLSIQWSMGEVKCSLRDYPLPMLRVQRVESGESQPAFRMETTMIIAEELGDEQSVFHVPVTVIPEACGDKNAAAFVVQVAKTISPVKTYAEPRFKIASKRTTEFTWGNSYQPAIQDFMKVVETLSHPPADPSPRVGFWDKFRLVLHWKPIVDFVGPCHLHLKGSFDPYSVSGIGSGFCLAWRGSTRLLIDQPNEEGETIQIIADELVVAIPDLAPFHDGAAIGNNRNGQRHDRHHGQSQDRHKSGDFEQTLIERRYTKPCARFVNGVKVGFGFEFERTCRPWTCDTCGKSENVMHRKCRLFEFKQHQDVRLRSPAAIAKDEKELGRKIDSYEGFRSDFVHFSISLSAPNGNEDIQSEEYHPDRVNSLHFAPKASHHFLAWWKLFSHQMSLPIRHGSLFPDSPPPSKKFGRSLGTIKYRFDLRPVYISHMYFQVSKDHSATGKSESLGIKGRIGRIRADAHQRAQEKIERHEKLGRSTVVVHKPFYAVDILADDIKVKGLRAHFDEHIGGPGENGGEAGVLHPKASELPLGHREWYNYLDYIDADRKPIDKNPRIELVNFGECPHFFYCKRVKARTSTSGDDSPSQATLGLETSKFGHEPTHPCYLGTAEGVREVQQSLTRQRINELREKLSNYPLEGLSQDGDQLDKTSLVQRINILEKHHQDLAHETRRLSDHTFTDPNAPRDNSTGAKEGFEDTIHVHGPRLFLSNSSRNIAIKYMYMMGDRKKEEYFTSYSSLRSILEGFQQRMTRQRSYSYDEQVVEEQSAQQILNDLVSWLVEKPASESIHHVEDPVMAAEVRRGLPDVCDVKPKTKILVFMPQIALRSEAHPDAILLMSMEEVSFKRFKVLDEHALDNMMAEVLNRNYVTMSGLQGFYPNENALNRERTGLGLPHGLDFIPLEIFLDVKSEAKDYDRVLQKTTINVAMDKFNHIRMPQGLEWPEAVDDRGDVIKHLRLHQDFTAIVAPTLTVTANSQNFAALYTIVTNLLMYDDPEHKGRSDAVDDFSRTFDAADRDIPRLIADVNALQTHMRHLVGLRHGYESHFDQLDKDGQEELFKIRSELHAGYESMYTVNALIRATLAKDDARAAMKTASKMDVRIGGVAWHMLKDQRLETMAKVDITGVLFSMLNNKNGTMDNAMVLGDLKALNGRSNMLYPEIIVRDEPAKRKIKKAFSAVYWSTRPPIGGIPILPNVNIEFVNILFKLEESVGLEVMDYIFADRTRRREATGTAVKGGIENSATTPNSSFFGKGNGNGNTNASASTDDLGSRRANASTTDFGSVHKSKSQVSLVPSQADGDIALIKMIEDTREMRLRASTNKMFGTFRLQGMGLNLSYKSDDSRKHGTFSMPDCVDFKFKTPEMVYVNKVWAMEDLFEHIKRDIKNSAWSQSGDIISQIFKKTSLFRSKERLKQAASVTAMAEKAQKGKKKDQGNPPISPSNLRYTMDHSSPSPEPDPELLSTLSRALSRDAELANNNSINRMRSRSTHRAMSMSAQRPSTPQAGRRESAAASNGLQTSSLGRSSGSRYASTSLEENRGETRDSGENGDNEEKSRIKGFFGKLKAKNLGHGRESRYSEDSSLSGSRVSLRQQAHPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5B5</accession>
    <name>A0A1E3J5B5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mutanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031500.1">
        <property type="nucleotide sequence ID" value="XM_019176572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5B5"/>
    <dbReference type="GeneID" id="30193666"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="51840" checksum="6B28F56CD0F85DEC" modified="2017-01-18" version="1">MVGFVDAYTQDDWTRDIELAMSKGIDGFALNCDGQDANAQQLTFAFKAASASSTPFKLFISPDFVHYSTEDHEPVSDLLKSWITEDAYFRYNDKPFVSSFWGEGTDWEAVRTDVGQDLYVVPYYYASQSAAGTKGVDGLFSWSAWPGEGTEDVVNQNMTTDKDKEYLDLLGPLDKTYMAPVSPWSSTGYSKNYYLYSDTLWPTRWQQILSLTKSHPDQLKFVEIITWNDWTQSSLISPYRGTETTDGNEAWSKDFDHSAFMDMMGPFITAFKAGSEDVSVTENRLVYWYRPSLKDAECDSTDSVGSKPSGAEMAADSIFVAAMTVGAATITVTSGSSTSSQIVDKAGVHTLSFPMEAGAVSFEMKMDDGGRASGKGAIEVTSGCYNDVYNFNVLSGTITVDDGSTGDSASSSPVVSETTATSTGTVNDSSPSINAVSEEPGLAAGSSSSNSADTIQTAVSRPSWGITTCDTQPRALLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5L9</accession>
    <name>A0A1E3J5L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3A subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031221.1">
        <property type="nucleotide sequence ID" value="XM_019176746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5L9"/>
    <dbReference type="GeneID" id="30193842"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000003">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="217" mass="24813" checksum="1EB1CC273885F452" modified="2017-01-18" version="1">MDYQNRAGANKGSGGVAGASETAIDRRERLRKLALETIDLAKDPYILRTHLGTLECRLCLTLHVNEGSYLAHTQGKKHQTNLARRAARDNQDQQLMIQAPQVEQTVKKAFVKIGRPGYKIIKIREPVSQRMGLLFTVSLPEIKQGERPRRRFMSAFEQRREVPNKALQYLVLAAEPYETISFAIPSKEMVDAEEDPESTWEHWDGDEKVYSCQLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8P3</accession>
    <name>A0A1E3J8P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031840.1">
        <property type="nucleotide sequence ID" value="XM_019175927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8P3"/>
    <dbReference type="GeneID" id="30193014"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="140"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="578"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="860"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124099" checksum="A1577829E4C25CDC" modified="2017-01-18" version="1">MPPQDSGSPLRLKPPAITLVRTDLESEPSNGSSHDSPDDRVPAHFRLPALQSPKRNHVRIESQDTAALPPSEQDAEDHRSHTKRPSSAITAEGKNATNTSRRSLSGDDSGDRAMRSWPEKMVTFAQLRAQKIAEHRYFSWIGPKLTWGKLKPVLRSAVSSWLGLVLIVIVPVERAIGTGSFFILIVGFMMPPYEPVVQTLEKYINLFLFASMSWVWVIIAIAIAGATRGPLDLDKVAKAEAKWGFLKESNPTKYQQRIIFDGTYLQAKPAVVCAVFLSAGTGALLWWKLRTSPSPATFPLVLSCILIDVSLTTAVFYPTNVYDIGLIFFLPMAIQAGIGTLCSILIFPESVGHSFQSKFGGVLDPLASAMKSIDELFSEAEQTVADSEDDDFLSARDTQREREGCADRLENWAGRCKGIRTKLLQSLTGLPPLRAQQRYLSVDISYSRLSGEDLRNLFDHLALLQARSGGMAFFFDVIITNAKHSHLDSSAWSVQQVAQSRPGSRATSIRNESLDDRHDNGEYEVRDDDAATPALELEDSADGSHNPNHYFGSKRFSMPGILRRSGSPHGISNSHKGSHMSLLDHLRKSQQPVGIYESTRYMDIERNFAVDTAQVLEQLDILARGCVPVIRGCQSALSKASQWIVNVNHDRHIMTWASQQTQNHKKGALDDALSQVIATLQGALDDFQISRLQIIQPYKHLFDPNYPAETGLRGKIHFRGLFQNFVAQYHLIEFSTALLELLRMMQDLDRSRPDRRLWFPRISSMLSHLQHSQKEKHLTEGDEEGHDNDAAFNRDEDELLGEAKTRNPEYKPFDSSWLNLVAKAIKVLDIFQSRSSMFAVKAAMLGALTTLPNFIASSASFYYFNRGVWCTIMAQLSKHLGYAGDTATAWLSRVVASSWGCLLGMVIWYISSGHGQGNPYGVAAACAVIFPIAAFFRVHFPGPVLTAVMLPVTMGLVIGYSYYNGTIGPLTHAEWGWDVAWRRFLCVLIGISAAWVFSYVPPVYSAKRAIRYSYARTIGITGSILCEILSHANDPHYHLKEDDEILKQLIAWRSKLNKLGARHINATREKSLRGKWPEERYKLSDGGCTRVQQLYALRPGNHYYVLACVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8T6</accession>
    <name>A0A1E3J8T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031869.1">
        <property type="nucleotide sequence ID" value="XM_019175956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8T6"/>
    <dbReference type="GeneID" id="30193043"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="377" mass="41780" checksum="6322875FCA541164" modified="2017-01-18" version="1">MEHPVMGTAPSDRHQHEEADEGHVDDYLRHSPGESPAESSPPPQDERQCRICFSGPEEEESMGKLISPCLCSGSMRKAYMECPQCHFKYRIQRTRISGLATSKPVLILSTLSLFSLLTLSLGSTFHFILAHSSTLSRTFLSPSSGNLRLGGPMDLFDDGFMDQGNVIIIGSGGGTLVWDVLVAAIQTFASIADKLGRYHSVLVTRLPGPLATLVLGIAIRSLLGIALLGSMSFLSLSISMSLFGPLQLANALRGGFLGSWGRRRLARGGRGGAAIVVALVAIGTLNTLRQVYRRVGRLATRLLKYVESQILEVNPDEEREGERRRMARREKWLRQWLVERRWGTVHGWKEAGYRGWITARGWWDDIWEDVAVDAHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Z7</accession>
    <name>A0A1E3J8Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031950.1">
        <property type="nucleotide sequence ID" value="XM_019176037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8Z7"/>
    <dbReference type="GeneID" id="30193124"/>
    <dbReference type="OrthoDB" id="2562239at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN97348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31448" checksum="DA55263B13DC8F03" modified="2017-01-18" version="1">MSSNTTDISDFNFTGGFPTSTDLAPSIVFLAIHQYVLAIPVLVFRLVRKQDRTMILIRPAVFVACRLGSFGLRAWMSKNTYNESELIAELVMISIGALFLIAPLISCWTNHVESEVRPEDRPRWLSLLSKALHLLLMACIATAVVGSSMIGSAIKDPSKMDTVTGLRRASLVLSVVVVGLVGAGITLTAVNYNLSRRGTAWLYVLDGCLLVITVYKLAQFENTDSDSVAQSRVAFWILQILFAFSLIMAISLPTWFSSVDHEELLLDIEMGGQKNMGNPSMASLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J940</accession>
    <name>A0A1E3J940_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Large subunit GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031964.1">
        <property type="nucleotide sequence ID" value="XM_019176051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J940"/>
    <dbReference type="GeneID" id="30193138"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="744" mass="82901" checksum="3A6E60AE2547F396" modified="2017-01-18" version="1">MPPRTKTQTSGLGKALKNRKAKEAVAPKESQLYTLDDNNPLASVTHERDLDEFLANAALADQDFTTERSKMRIISAPGMPVPEGNPFLLSAAEEKDIVKKKAAFEGGLTVPRRPYWTRQTTRLELEKQEREAFLEWRREIAKLAETSNLLLTPFERNIQLWRQLWRVIERSQLIVQIVDARNPLGFRSVDLENYVREIGSDEGAEEITVPGKGHRRSLLLINKADLLTYDQRCAWADYYERHNISYAFFSAANAAALQEQAEKQRLRALGEYPGDQQESDSSDEEAENSVEEDDDAPETELAQDLDETHMDDEDEEDWASDEDDNVEQGKLEKTLVDEKLEKGETIPLEKVAQDVGAKYGESTEEEEDIRTRVLSVTELEDLFINSAPGLEHFATPQYPNPKLMVGLVGYPNVGKSSTINALLGSKKVSVSATPGKTKHFQTLVLSDTVTLCDCPGLVFPQFADTQADMVVDGVLPIDQMREYSAPVTLLCKRIPREILEGTYGIRIDVREVDEGGTGEVGWEEFLSAYAIARGMTRSSFGMPDTSRAARYILKDYVIAKLLYAHPPPGISPDDFMATSREESIARLEEEFEQGRKRAPVSHVSRNADTYVAPAGSQGVDAAMPEDAVENVKRERQATSKQIKANAASAPARSGRERISALDNVYFNEGGQQPRLVVKGRNQPGELQEGGQGFSRKTMYPHQRMLGPDGMPIIGAGDKGSEGADNGKRHFKRKEGKKRSGRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9D8</accession>
    <name>A0A1E3J9D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CORD and CS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032069.1">
        <property type="nucleotide sequence ID" value="XM_019176156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9D8"/>
    <dbReference type="GeneID" id="30193245"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="248"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN97467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="378" mass="40651" checksum="1991EC33FFF56633" modified="2017-01-18" version="1">MAIVKCTNQACGKEFDEEKKEEGTCAYHPGGPVFHEGLKSWSCCKDTNKPVLEFDAFMKLPPCTTGTHTSVPRATPSVPAQKPDTSNSAPAMTSSKDGVETYGSVPPPSASSGSGPKIENQTPVLPTPAPAPAPTAAIVGGGKQGGAEEKKEVKEEEDDVSLPVPEGARCKRTACGAAWEGEEVSRGEGEKATCRYHPQSAVFHEGSKGYLCCKRRVLEFDEFIKIKGCKEGKHLFVGQKKDETKEEFVNCRVDHYQTPTQVHVSAFAKNADKQLSKVTFTDTTLHLSLHLPSLRRIEKTITLYGPISPADSSYRILGTKIEITLTKPKAASWPVLELPPAGTELPPGYALTFGVRGRTGTVGGKEIVLAEEEVGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBR1</accession>
    <name>A0A1E3JBR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_03562</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032180.1">
        <property type="nucleotide sequence ID" value="XM_019175690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBR1"/>
    <dbReference type="GeneID" id="30192775"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN98318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="487" mass="55435" checksum="5FC2225E299FA4B7" modified="2017-01-18" version="1">MRCTSLTPFSTDVIETFFDSRLDLFNRRLKAQSSRLKNRAVELLPKGLRTPKGGGILLLDEEEEEDSDEKAERVNPADKYRRDVEREVDRIKVKLAAKVTHLSATWRSDQVIRTRDKVCFLFGVLSLAFTAFVYGRCPEWLPVAYTVQAAFYLPLRIYTYKKKAFHYFLFGDLCYFVNVLDLLWIWIFPSSTTLLIASYLLTLGPLASAIITWRNSLVFHSIDKVTSIFIHIYPPIVLTVIKHMYPGREERFPGLQGVDDWSWYGMILVAGGPYIIWQATYYKFISIDRKTKIESGQRETSFHYMLNDKRGPIGKALKGVPVAHRELWFIFGQLIYSIIFMIPPAALLIHSANASYIFIVLIFAASTWNGASFYVEVFGRKFERELEKLRKEMEEASRTLTPGPGSTPAEQTSPASTYATISPSPTPPPEKEKRKIKKDDELANSPLVLPGARKSETAGEMEVPEMVLGKAVEEAVGESEGVRQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBU8</accession>
    <name>A0A1E3JBU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032189.1">
        <property type="nucleotide sequence ID" value="XM_019175699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBU8"/>
    <dbReference type="GeneID" id="30192784"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="272" mass="30438" checksum="F1B6854BF99C5F7C" modified="2017-01-18" version="1">MSFSLPFKYINAEELAELIKAKPVSEVKDWAVVDVRDSDFAGGNIVTALNYPSDTFHAKVDELAEKLETGARVSSTSFRHTCRGPKAARIYAETRAHHYPNPSTPQEIYVLRDGFSGFQSRYRATGVVPAFNQIETHPSLIQPELYEYANKKGIVIIVITAYSPLGNNTTGKPRIVQNPDIIKIAEKLKKDPAQVLVAWGAYQGFSVIPKSVTASRIKSNFEDFELPKEDFEAINKIGKANYARANAPADYDLVWPINIFDTESEKQYKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBZ1</accession>
    <name>A0A1E3JBZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Arginase</fullName>
            <ecNumber evidence="2 10">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 10"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032033.1">
        <property type="nucleotide sequence ID" value="XM_019176120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBZ1"/>
    <dbReference type="GeneID" id="30193208"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="394" mass="42107" checksum="FC2BDFBFD0350EE9" modified="2017-01-18" version="1">MLARSSPLLRQSLAGPLRPSRLALPLHRTLHSSCPAAEYKVTAKPAEDSTFKTPNYEYKFLNKPATATLVGCPFSGGQRRAGVDLAPNKLISAGIIDQLTGLGWHVNYESQDTFLDIPYNPLPSSSPAATGTEAAPSLSGERMVQRLPDPDIGIMKRPRLVSAVNEKVAKAVGDIAGRKELPVTLGGDHSLAMGTIAGTKSQYPDAGVIWVDAHADINTPLTTESGNLHGCPVSFLMGLEGCDVEPFNKWLKPCLKPKDIVYIGLRDIDNGEKAILKKHGIKAYTMHHVDKYGIGKVMELALQHINPTGERPIHLSFDVDALDPTVAPSTGTPVRGGLSFREGHYITEVVAETGCLVAVDIMEVNPSLLDPKSVEMTVAAGCSLARAALGESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCD4</accession>
    <name>A0A1E3JCD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_03779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032395.1">
        <property type="nucleotide sequence ID" value="XM_019175905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCD4"/>
    <dbReference type="GeneID" id="30192992"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN98533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="108" mass="11578" checksum="906507E4086DC3C4" modified="2017-01-18" version="1">MARLGPEPRINSRYLNDHIGETVRLAAKVTGVSGDTATIQTSDGGTVGIHIPRDMHIQDEYVEIIGTVKEDSTVKAHTHIGLGKSLDMKAVNSVVDFSHSDIGSGVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCE4</accession>
    <name>A0A1E3JCE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_03775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032391.1">
        <property type="nucleotide sequence ID" value="XM_019175901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCE4"/>
    <dbReference type="GeneID" id="30192988"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="74"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN98529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="410" mass="43526" checksum="6841465887CFBFD6" modified="2017-01-18" version="1">MPILGLKAPGPSAPAHFDLEPLIRPNILALQPYRCARDDYSAGVLLDANENAIGPSLPRLSSTLASDDASKVAAETLSLLSEAEIANLNRYPSPTHDDLKREIAKLRGVPDENWVFLGVGSDEVIDMLYRVLCVPGKDRVMTCPPTYGMYKVTANVNDVGVLEVPLITEDGSFQLDEPALDAAFESNPDVKMLFVCSPGNPTGTLIPLPAIQKILENPKFKGVVVVDEAYIDFSPQGSSAASLVNEYANVCVTQTLSKSFGLAAIRLGYLLAPPPLIQILTNTKAPYNVSVPTASIALKAVSTEGAAAMSCAVATLNDNRQSLIDALSSTKGIGRILGGNHANFVLAEILGENGKPSNQKALEVYKTMAESKGVVVRFRGTEKGCEGCLRITVGTAKECEEAVQSIASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF89</accession>
    <name>A0A1E3JF89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S small subunit ribosomal protein L7e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032584.1">
        <property type="nucleotide sequence ID" value="XM_019175481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF89"/>
    <dbReference type="GeneID" id="30192564"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.15.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="250" mass="28297" checksum="696567899213B978" modified="2017-01-18" version="1">MAASTTVPTAEQIAVPETLLKKRRTNEATREAKLAAAAEARKAQKAKRKVIFKRADEYVKEYLNAEKEEVRLKREARKTGDYYVPAQPKVYFVVRLKGISKIAPKPKKILQLLRLLQINNGVFIRVTKATTQMLNLVNPYITYGEVNLKAIRELVYKRGYAKVDGQRIPITDNAIIEKQLGKFGIICLEDIVHEIATCGPNFKQVTSNLWPFKLSNPNGGWRPRKFIGYVEGGDAGNREKAMSKLVHQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFC7</accession>
    <name>A0A1E3JFC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Na+/H+ exchanger AnNHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03422</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032655.1">
        <property type="nucleotide sequence ID" value="XM_019175552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFC7"/>
    <dbReference type="GeneID" id="30192635"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="889" mass="97793" checksum="B3C0740BE78BC506" modified="2017-01-18" version="1">MPAFSPFEVNAAHLAYTFLGGFVVLFGMLSLFLKEKLYIGEAPLATVIGIIIGPHCLRLFNPSGWANGNDDTVDEITLEVTRVVIAISVFAVGVELPKAYMKRHWRSLFFLLGPCMLWGWMISALLIWGLIPGLNFLASLVIAAGVTPTDPILAQAVVGGKFADQHVPAHIRHLLSAESGSNDGAAFPFLYIALYLLLDNSPGHAVGEWFYMTWAYEIVLGILIGAVLGFSARKFMKFAERKRLVDRQSYVAQYVSLAVMTIGVTSLLGSDDLLSAFACGCAFAWDGFFNKATEDAVFSNVIDLLFNCAAFIYIGALIPFSNFNTPDVSTLRVWRLVVLALLVLLVRRLPAMIACYKFIPDIKTFREAMFTGWFGPMGVGAIFISTLARTSLPEGEADMNTEVVDRLREVIGPITAFLVLSSVVTHGMSIPFFSLGRRVHSITYTRSRNLSMDTRGDEPAWTTHARRVVPGQDIVINRDDDDEEGDLGIVRRDTLHSEANVHLGGKIVEEDSGGSSSSGGRPGEDIEMVEKRRRSSRGSEEAETVELEPRRSRTSRDESPKSSVEQAEEEEGDEIIHSGGRSTPPLAEYREGPHLVIERKAKDSDEVEVEVIRNHFSDGKKPERESFTHPHRLKSKELDELLQHLPKSLEHATSRVQDGGKNAVDRLGLGLMRPAGTPVGTPSEMSESPFRIERTDSPESLAEEGRMGHHNHRFSHGSEGVENEEDYEDVEGEEPTRQARKYQRPPAIHVSRQNSAGPPRRSIRARLFGRRQQSSSSPSRLEEGTAIPDSSLLAPSSALNRPQSVPDDSRTQSQSLGIPLTRTMSSSRPAVRFAEDTSMSSETAPGQANYGSNNPGFRRNPALTMSRTASVQSTGDGPSVSFVEPEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIG3</accession>
    <name>A0A1E3JIG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032881.1">
        <property type="nucleotide sequence ID" value="XM_019175149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIG3"/>
    <dbReference type="GeneID" id="30192228"/>
    <dbReference type="OrthoDB" id="5514856at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="64" mass="6913" checksum="ED85E10E851572D6" modified="2017-01-18" version="1">MAAPQYLGPATTQEPATLISYLKDQVTNPQHREGNLNILKATTIFVLGIAFVRSDLSAALVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIT0</accession>
    <name>A0A1E3JIT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033001.1">
        <property type="nucleotide sequence ID" value="XM_019175269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIT0"/>
    <dbReference type="GeneID" id="30192349"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130388" description="PLC-like phosphodiesterase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="37989" checksum="0BEFAABCD847AF55" modified="2017-01-18" version="1">MPSLPSLLALPLLAALPAIVTAADTCNGHSELCSQLYSNVTFIGAHDSYAVGSSVASNQDKDVTSQLNDGIRTLQVQAHNATDGIHLCHSSCSLLDGGLLSDYLSSVASWVTDNPNDVITIVIVNSDNLAPAAFESAYSTAGLTDKAYTPDSQPSSLSDWPSLSDIIDSGKTVVTFMDYEADVSSVGYILDEFTAMWEDAYDVTDASFGCSVNRTSGDSGSQLYMINHFLDSTYSFAGTQFYVPDQSSLNTTNSETGDGSIGYHVDNCNQIWGRKPNHILLDFYNSNENAPFNVAASLNGVSAPTSTVAAGSVAASAATASSTSTDAAVSSQSISGAEMKMRHGTLSGLVAVAGLVMGMGMVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIU9</accession>
    <name>A0A1E3JIU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectate lyase</fullName>
            <ecNumber evidence="5 13">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5 13"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032947.1">
        <property type="nucleotide sequence ID" value="XM_019175215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIU9"/>
    <dbReference type="GeneID" id="30192295"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF8">
        <property type="entry name" value="PECTATE LYASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025091987" description="Pectate lyase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO00755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="253" mass="26496" checksum="E313D125393CA3DD" modified="2017-01-18" version="1">MLASTLLSLLPFLAMSSATPQIIPRSSSYTLPVPTSQGNVTYSSAQSISGTFDGELKTYGRGVSCTGQAEGGNSNAVFLLEDGATLKNVIIGEDQIEGVHCLGSCTIENVWWVAVCEDALTFKGDGDGSVIGGGATGAEDKVIQHNGIGDVTIDGFTVVDFFGELYRSCGNCKNNGDTRNVNISNVKAYNGKVIAGINSNYGDVATITDTCATSVKQICTEYEGTSDNDEEPTKLQSGVSDNCVYTESEITTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIW9</accession>
    <name>A0A1E3JIW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033023.1">
        <property type="nucleotide sequence ID" value="XM_019175290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIW9"/>
    <dbReference type="GeneID" id="30192371"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000065">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="43"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="254"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="339" mass="35835" checksum="B1A5B78AEB9A00CB" modified="2017-01-18" version="1">MSTPNRCLVRGSISESPAILHNRAHQTVSDIDEFFHLPHIVRPGETISSTKLTKRAGGKGANQAFAVARAAGQVDLDGAIGQDGVWVQDLLASAGVGVKRLLTVDDEVTGRAVIQSSQDGENSIVLHAGANYHVPATNAPPSISGYTHLLLQNEIPLASTLSYLSSAGQSSPPVITVFNPSPMLSPQQLREFPWKYLSWLIVNEGELGDLLLAFGSTANPGTASEDELREKASAGILELAANEYFSPSVGIICTLGAKGILYYQPGQKVGYYPAAKLQYPVKDTTGAGDCFAGYFVAGLMSGQSLEEVLQSCLTACAICVESEGAMESVPTREAVAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY9</accession>
    <name>A0A1E3JIY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033010.1">
        <property type="nucleotide sequence ID" value="XM_019175278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY9"/>
    <dbReference type="GeneID" id="30192358"/>
    <dbReference type="OrthoDB" id="2564755at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="41940" checksum="B69BC266DB5AFB19" modified="2017-01-18" version="1">MAVPGPPPDLDGPISGADFRRLARGNPLPGERPHPVGGGRRIAEAAAPPPTQNEDFSGLEGLFPGISTKTGAWTPGGAIQQGLAQGKGVHQIPGATTLPPPDHPHAWASPGQQANPNPMSASLWRGYDMPDKPGGGLMDKFGEWWKGPGGASDPWTAYPTSALPGLPSSIPPSHRPLPSGKDLDADWGSGMAYPYSGGMGGLGGGLGGGLGGGMGGLGAYKPDLMGQISFGQLSREEQRRLVKKHEKQMKEQAKLAKTAEKLRDKEAKRNKKKQAKKVKTEKKAVKRLEKQMMSGKHPWGGYPPPNHHPIPLPYAASVTRRPEATKPSPAVQPNPKNEYKFMYFPTSDFGLVKPPNSTGLPKEADGKEKWPAMTNFGMEDKHYHMRVINQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLS0</accession>
    <name>A0A1E3JLS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033067.1">
        <property type="nucleotide sequence ID" value="XM_019174688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLS0"/>
    <dbReference type="GeneID" id="30191755"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO01815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="448" mass="50094" checksum="F40C817DC1A5203E" modified="2017-01-18" version="1">MSSRTPDQPIVGIIGMGDMGRMYAKRFEEGGIKTIYVCDKPDSYASLQADYANSTITPLKDGHAVSRLSTFIIYSVEAAALPAVVREYGPSTRVGAVVAGQTSVKAPEKDSFEKWLPEDVGITSVHSLHGPSVTTEGQPLIIIHHRGPQGNVKMVEDVFRSFKSRYVYLSYEEHDEVTANTQAVTHAAFLSMGTAWQKSADYPWETTRYVSGIEVIKVNITLRIYSAKWHVYAGLALLNPSAKTQIHRYAQSATELFKLMVEGRGEELEDRVWKAREDVFGWKRGEEAGEGDKTRAPILLGEDVLDQFSLGKAPEQGRERASQNSHLSLLAMVDCWAKLGIRPYEHLDVAGTPVFMLWIGVAEYLFRSPTILSSALSAALSDRIHRPDDIEFVVAARGWSECVDVGNFEWYRRRFEETSEFFAPRFEEATQLGGKMIKAVQEGRRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM26</accession>
    <name>A0A1E3JM26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033125.1">
        <property type="nucleotide sequence ID" value="XM_019174746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM26"/>
    <dbReference type="GeneID" id="30191814"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="282" mass="32465" checksum="714E6B1F543C05D2" modified="2017-01-18" version="1">MFNSAKQQCNKRKGPSYIDLTSDGLDTDSYADQKKPPPRKLAKSASMWTDDSHDVKLVSSDEEAFYVPSYMLKAQSAVFRDMLSSELLDPFLSRSDGNAKLPPQRHHHVLELIDDELENAENLTIVLTLLDSLDYTLTDFVTTHKSKTPTIMWSILLFAKKWDMPFLCSRLSDWICQLAVESHKPPYNKFSQFDFFKLAACSGLPHAASVVLSTWWCPKDKPEWTVWAFTGCRPLNPEFLTRREWVALPPEYKRALQRSLTLHPRDRLARAREFQAMVTTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMA1</accession>
    <name>A0A1E3JMA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033240.1">
        <property type="nucleotide sequence ID" value="XM_019174861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMA1"/>
    <dbReference type="GeneID" id="30191932"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000535">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="162"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="452" mass="48629" checksum="75E851CB273EEE30" modified="2017-01-18" version="1">MPPKASAAHHAPSPSPPPHINHGQDLLVIQDIADTLDQIPPELTRVHSDLNELGAVLYSTLVSLEKKLHTLIGWIQDPTVTSEKRFELLQEIAEEAARYKLGGDDKIRVAAGACDGIMNHQKHISTLLKSATLLNPSPPSPYSQALTLPFPAPAPTGRRVARAVNSPFGGKGYSGSNAGPSETRVGDTPTKQKKRSRVQQLGARDDDESSSAGGGPKKVVKRRKQNRAASPTESVVSTSGFGGKAVEPRTARQLAAAANRARREAEDVNSDTESRTGNDDGPSTTKKSGPPMQPTFSTDSKGLGLDVGSREGSRSANATPTLAYASTLPSQTDVKRPSRRGGKRPNAAANENDDEEEEDVYEDRRDAQVADMFEDGGGAGDEVDSNVYCTCKQVSYGEMIGCDDDDCEIEWYHIACLGLDKTPEGNWICPTCAERRRKQPKVKKATRGRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JME0</accession>
    <name>A0A1E3JME0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033293.1">
        <property type="nucleotide sequence ID" value="XM_019174914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JME0"/>
    <dbReference type="GeneID" id="30191985"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000004">
        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="117" mass="12818" checksum="9F60E526ED770444" modified="2017-01-18" version="1">MSRELISNEEFPTKPHNCPAVKVPGLVFCAGQTATGEIKQATLKVLTNLKKLLELSGSSLDQVVKYNVYLKDMKDFAAMNEVYIDFLPKAMPSRTCIQAGDLPGEGTIIEIECIAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JN72</accession>
    <name>A0A1E3JN72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">L198_02837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033358.1">
        <property type="nucleotide sequence ID" value="XM_019174979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JN72"/>
    <dbReference type="GeneID" id="30192050"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO02106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="338" mass="37725" checksum="55809A7FE38860FB" modified="2017-01-18" version="1">MSLRTIPLPLRSLPRHRALPRASSITSRHLTTFKSLRSAAPSAFSTINASEISHFSKLSSQWWNETGEFALLHRMNPTRVEYIRQKVALAPTGNEEWSFETRHLDAQREAGKGTGRWLDGLRVLDVGCGGGLLSESLARLGGRVVSVDASESNIGIAKTHASQDPFLADKLEKGELDYRHSTAESLRDAGEQFDVVCSMEVLEHVDEPGEFMKCLGEMVKPGGHLILSTISRTPLSQLLTITLAEDVLRLVTPGTHTYRKFVRPEELRRFVYSDMGGFGIWERNEDASDIRDGEVGETRGIIYDPLKGGWNLWGGVEGSWFKDLGEACNYMFYAKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPZ8</accession>
    <name>A0A1E3JPZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033234.1">
        <property type="nucleotide sequence ID" value="XM_019174855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPZ8"/>
    <dbReference type="GeneID" id="30191926"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="128"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO01982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="39349" checksum="690E6137982FCAF8" modified="2017-01-18" version="1">MSHPNATASSSKHKKDKSHKKDKHRDSKDKKDKKHKHKEVKKEGKHDKSPFEHRISRMRISVPPKFAGDVMMGVREQLDGMVMRYVPQMGGVLLAHWEHSFEDETAKIVGECPFGVVEVEFHSVLWAPKIGQKLFGAHSLSSPSHLSLLFSKTFNVSIPLQHIPAELYEFEHTDETAPEEDSDSEDEVEYLGGMGNLASAVEEVGRWREKANGKALGGDIKFTVIGMQVTNQMLSLTGSLLSDPFNPPALPEPVAAPAHSPSPSLSPEPQARPQKKARVINNAPEPKEEEVDTTGMTPRELKAHRKEQEKKKRDARKARKGDEQGEEDEQTAGTKRKADEDNAEGRKKKKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA1</accession>
    <name>A0A1E3JRA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033426.1">
        <property type="nucleotide sequence ID" value="XM_019174374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA1"/>
    <dbReference type="GeneID" id="30191434"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130503" description="Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57997" checksum="FFD3C556F745AD29" modified="2017-01-18" version="1">MLLVLTVFTLIAGIIDSAIGSDDVMERFNSWSTDKLDYLTLFGGGEVRACRGWDPAAPEWSDPAGCLKAKQYRQAFKVLERERSRKHNHYHFAIDHNIATLEVMLRCFLPTSDAEYTPCHEKPLIISGWWYTAAVLTDSTTGEVVWQRFITQQLEKLGYFWIAVGPYTNWIEVAEIMPDVYNTLWNNDVETLSCITDPRCIAKEDYVPTEGGEDLSVGVSDEERGVIPLWALNVVDYWGARPKEILHNTHWWGLKDPWPLPAGHHHLPYSMEEECLARPTTPLEERKDAGLILAKRSSYFHYHHVSPPELWTNLTQNDGVELISVANVEEGKPMPVGLETIGKQTVQDYTKLVGDVKAMVGIGIPVISPSVYAAWCQATPVVIPIFHDEDNSSPWHPYSDYSQHGPALSVGEPYAYSYHAKNYTQLVEAVHKAMSTPIERFIPDDMPLSHTMKALEAYMNRDLVKMMELKVKANGGKIPALKAGLRERCIELDRCMPELPPGRVPSGPSSFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRC1</accession>
    <name>A0A1E3JRC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial intermediate peptidase 1</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_02242</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033446.1">
        <property type="nucleotide sequence ID" value="XM_019174394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRC1"/>
    <dbReference type="GeneID" id="30191455"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="212"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO03395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="722" mass="80042" checksum="9AE886C3F9712F62" modified="2017-01-18" version="1">MSPCSLKRLTNRTLVHATAIVDRIVSAPFDPTGKELRLVIKNLDRLSDLICGVIDMCELVRNAHPDQSWKRESDQAYTVLCGFMNELNAKRELWESLVKATTHPHPEPLSSLELKVAHTFLADFERSGIHLPPVARANFVKHSDNLIPLGRSFLSSAHSGPSPTPAIEIPRPESLLGDNLDAEFVHQLPRNGRQGPALVVPGSWEASMISRHARDGEARRLVYMGSMREDKDRVRVLEEMLTERAKLADVLCKESWAHIVLADKMAKTPHNVMGFLESLLQHNHLAAQADVARLQGLKWTALTGSPSESSTRVRHLAPLYAWDKEYYSRKYTSSLSPSGELPSIAPYFSIGTVMAGLSTIFSKLHGISFRPSSIAQGEAWHSSVRRLDVLDEKEGVIGYIYCDFFSRPGKPTGVAHYTVRCSRRVDDDDVDGDRMSPGWDKSYGGGLETRGEVLQGKEGRFQLPIVVLMTDFGSVAEGSPALLDWNELETLFHEMGHAIHSMIGRTEYHNVSGTRCPTDFVELPSILMEHFVSSPEVLSTFGRHYITGEALPIDLIESHLRLNQSLSALEVHGQISMALLDQKYHSFHHGKDSLDSTAIWHQLQTDVGVIDPVPGTAWQTQFGHLYGYGAMYYSYLFDRAIAGKVWSTLFTGPSPRGIFGDADAGGILNRDGGDVLTDRVLKWGGGKDPWEMVGDVIGGHEGEVVSRGDKRALELVGSWMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRU5</accession>
    <name>A0A1E3JRU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033447.1">
        <property type="nucleotide sequence ID" value="XM_019174395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRU5"/>
    <dbReference type="GeneID" id="30191456"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33407" checksum="4FD55801173F6D51" modified="2017-01-18" version="1">MPVHPHIHLFLPSSDASISLEARLYLPLTANRTQPPLTLTDKLSSFTSNPVRLDELSIETVGSIRGLGVERLVVAAHPWGRMGGNMLDPNLQHLVSAVFSPSEMKDPGLAASSNGEPPKTAVLTYNVRGIGCSQGSQPWLGVGSDPADMAQVESATADLLGDIKDIFRFGYSWGSLLVTLAPPHTLLRRLLLVSPPCTIFGGITYFSNRSFRGSLGDLLAEGVHVKLIYGTKDEFTSAKVFQTFGEDLPAVIKKKEGASDIGTWEKVEIDEADHMYRRDYGEMLREELGKWLGWSAPVYTPLSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS20</accession>
    <name>A0A1E3JS20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L198_02473</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033674.1">
        <property type="nucleotide sequence ID" value="XM_019174622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191686"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000205">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="71"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="190"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="784"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1112"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODO03623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1583" mass="176244" checksum="889840D1064BDC54" modified="2017-01-18" version="1">MPLNIHLPKVDPTATGKRTPKTPQDEAIAFFSGEQDGEPVQVWQLALEDDGGPGPGKVYIRLPPPTRPYILRFSLEPGTDVTRNGVLRTDFPIDGGDFKRDDFKERKLPSNLSKPIEIDLPIAAPGAFCYFLEYDSPSGQGRIQGRRGYFNVDPIINLPARTPFFPDDSVTTTNPLKDESSGAILPKNATLKLDSLIIISVLAKWMGKTDEWEPFFAEASRRGYNVLHWAPLQQRGISGSPYSIKDQLTFDPEILKNPDAKDGGLEEIEKVLAFAKEQYGLGGVTDVVLNHMAYDSPWLEQHPEAAYSPYNTPHLAPAVELENALLDLSARLPSLSAPSTLHSESDLQALIPHIKAAIDSAKIWEFYVFDVQAEVRAVAEALLNDKSNKWDGAEVQGKGYEELAEVVKSSNIIDNYRAYSGRFITSVKPATAAGFIQAAYPEASPENQASKWGKVLDVMNVDLYNESNEDVEAAIEGVVGRLRFTRLEEGGPKLGEITQDKPLLERYFTHLPDNKTTSKHPESARYIANNGWMWAADPLKNFAEYPSKAYLRRQVIVWDDCVKLRYGTQPSDNPWLWEHMIKYAELLAGIFDGFRLDNCHSTPIEVGKAVIDAGRRVNPNLYVMAELFTGSQEMDLKFVRELGINSLVREAYNGDSVKNFADLLWRFGLGKPVGSMDVACLTSSGEINPSLPSSSSTTPRAALVTPLQGSAPHAVFYDLTHDNQSPADKRTAADALSTGALVTFCASALGSNKGFDDLYPKLLDLVTDNRKYEVVSKEQERESGIGGVKRVLNALHVEMMEGGFTEGHVHEEGQYLMIHRVHPITHKGYMLVAHTAYKGFEGRGWVKPIRLGRTSISYLFGAGIETKIDQWSDDPSTHRGIPSKLVDIAEPEIKHGEENGEAYQEVVVPENFAPGSILVFGTRMSEISADLDAFCKEGAEEAMKGLDLVDLNVVLHRADGEEKDATGGDGVYTIPDYGALTFCGLEGWMHPLRTITKTNDLGHPLCQHLREGTWAFDYVVNRLQNQTDDLPHLSAPAAWLASRFDQIKATAPSFMRPKYFSLVILEAYKAARKAVIEQSSEFVASGHSLTHDLAMVSVQMYGLVKSASIDPGRAVPSLAAGLPHFTAGWARCWGRDVFISLRGLFLTTGNFEAAKAHIKSFGSTLKHGLIPNLLDSTRNPRYNCRDGPWWFIQNIQDYTDLAPNGLSILEEKVKRRFPADDTWVAWDSPRAYEWESTVAELVQEILQRHAEGIEFREYNAGPNLDMDMDDRGFDQKIWVDWSNGFIFGGNRYNCGTWMDKNGSSAKAGNKGLPATPRDGSPIEITGLLKSTLTWVGKLSEEGKWPAQGVNTTVEGEKRLVTYKEWADLVQANFEKHYYVPSDASEDDKYVINKSLVNRRGIYKDVYGTPGDREWSDYQFRSNFTLPMVVAPELFTPSKALDALRVADAVLRGPLGMKTLDPADQQYRGDYDNSNDSDDKAIAKGWNYHQGPEWGFPLGWFLMAYLAFDQRVGEGKEDSTKTLHYISSILRKLSHHIENDPWRGLPELTNQDGQYCYDSCNTQAWSASTILDVLQLMHKVGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JSI7</accession>
    <name>A0A1E3JSI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033677.1">
        <property type="nucleotide sequence ID" value="XM_019174625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JSI7"/>
    <dbReference type="GeneID" id="30191689"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38470" checksum="AAB14129D46469CD" modified="2017-01-18" version="1">MSPFSILSKLTNPHAPSLPSSFGSSKQTTYYLSTSLPSPSIQALQARPPPHQLPPSSLIFCLKHPRLDTSPATAFFLQCLPDPIMFLHYAALFIRPRLALGPGGDGDGQAEGGWRHQLITLELEEKEGLAATSGGKIGVSLDWVERSRQEVMGGKKHVEQALREFKGVLLHEMVHTIQHDGGGSTPTWLIESIADLLRLFAHLEPAHWRKYGQGKPDKGWEASYDTGARFLGWLVGYDEAEREQVERGEGKLVWEPEVVAGTVPGPTPTGPEGAQATRYAEPPSVAEQKPLGRPNPRKERSGPYPDFVRLLDSRLVYERWDEGWWQEMTGRTLPQLWAEYLAYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU23</accession>
    <name>A0A1E3JU23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033688.1">
        <property type="nucleotide sequence ID" value="XM_019174636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU23"/>
    <dbReference type="GeneID" id="30191701"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="50052" checksum="F414437C93819041" modified="2017-01-18" version="1">MPRSPDRSEDYDVRPSKIRLKTTKSERAEKIFAREKRRFEKDQHRISRANGYAVSPPPSSSSHYRADSISPPRNKPRPQAKHYEEEEGQEGEWLGAMGRKVKEERWKREKAEWEGKMRWMAGEEGGGGGLEDWEDLEVPRWGHAGRAAESLPSRWRSAPSRPFLSPSLFPPPPSPFEPGSRPTRPKMHHFPSQPPPMGAMSENDYAEYIRTGMYAQKHASALLEADRIKTERMEKEAKRERERERREREEERWRRKQEKEEWERYRRRAREREEAEEAYRPVPPPRESATPPYRSSKTGQAKKDDPAKWTARWDALQAGGEIESSNLSFNDIPWPIFLSNLPSTHTPDDVLSALSLENVKKYMVTVASYKENTGGEPGKVRRVVREAVRSFHPDRFTVRVLGRVREGDRGMVKEGADVVSRVLNDLARQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU29</accession>
    <name>A0A1E3JU29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033483.1">
        <property type="nucleotide sequence ID" value="XM_019174431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU29"/>
    <dbReference type="GeneID" id="30191492"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000011">
        <property type="entry name" value="Related to DNA-directed RNA polymerase 13.3K chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="164" mass="18041" checksum="0FBBE995BD57BF1B" modified="2017-01-18" version="1">MNQPNRIDSWLLQDDEKPLTITEDPKLPNASTVTLRRQDHTLGNMIRAQLLLDPTVLFAGYKVPHPLENDITLKIQTDERSNPADALKRACHLLIRQTMQVKTQFQQQAKNIEMGMGPEQAPVAGGAAGAGGQAYDPYGDGFGREGNVVVGGQAREQGQDVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUJ3</accession>
    <name>A0A1E3JUJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_02452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033653.1">
        <property type="nucleotide sequence ID" value="XM_019174601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUJ3"/>
    <dbReference type="GeneID" id="30191665"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="3"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="13">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODO03602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="448" mass="47966" checksum="391065F99E0D76D8" modified="2017-01-18" version="1">MSSSSNAESIAVAARRAFEASQLVDPSERNVALYAIREVLEVHKDEVVAANKKDMEDTGKLSASLVSRLDLSRPGKFEAMLQGISDVGSLPVPTGIVNFAKELGPELELHRVTCPVGVLLVIFEARPEVVVNIAALAIKSGNAAILKGGKESIHTATLLSSLISQALSKTSIPATFVQSVSTRSEISSLLAQDRYIDLVMPRGGNELVKSIQNNTRIPVMGHADGICAVYLDESAVEEKAVRIVVESKIDYPAACNAAETLLVHSSLLNTIWPKVASALFSNDVRLRCDAASLGALHENAITQAAQFATASSPEDYREEFLGPTLAVKVVENVQEAIQHVNSHSSHHTDSIITEDEQAMSAWCRGLDSANCYVNASTRFADGTRYGLGTEVGISTGKTHARGPVGLDGLVIYKYMMRSRKKDGSVVGDHEKGGAGYTHRDLEKGDAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW89</accession>
    <name>A0A1E3JW89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033779.1">
        <property type="nucleotide sequence ID" value="XM_019173972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW89"/>
    <dbReference type="GeneID" id="30191025"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="169" mass="18185" checksum="CC24849206203029" modified="2017-01-18" version="1">MVSSIPAFRLVPATAQSSQDPHVVSTQPTAHAISGTHDTFRYGLRSAAQSVAPDNISPLQARLEKASPWKQTQLELQQNMQRTTFGLAVPMKQAMEMKLVSEASLINLHNPLLDQATPSGLPLGGGHNIALEILEGRDESIDADEFMGGGINFGEVLDVNGAMERKRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWH9</accession>
    <name>A0A1E3JWH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033808.1">
        <property type="nucleotide sequence ID" value="XM_019174001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWH9"/>
    <dbReference type="GeneID" id="30191054"/>
    <dbReference type="OrthoDB" id="10453192at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="210" mass="23051" checksum="4506C024588E2F2E" modified="2017-01-18" version="1">MPSRVAAPARARNPLLVLPLPGNQSLGLPVVKDKVEQTPVPSRPSGRDLNLAVCPDLIIEDASAPIGIVRFQDVHDYHTYYRCSACSLTGCYRGKLADDPTALNFHLSSDGHNQSVSYYMRSRSYRQGETRTTPCPSIIAPIPLRPFSSARSPILLKRQLSEDQTHFPDRVGKSSRVSSSANGRRHKEGVVSDDHPHASLEILAEIASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWI6</accession>
    <name>A0A1E3JWI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033815.1">
        <property type="nucleotide sequence ID" value="XM_019174008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWI6"/>
    <dbReference type="GeneID" id="30191061"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="926"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO05160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1217" mass="136437" checksum="754C6FD2288A388D" modified="2017-01-18" version="1">MSSPLTSTSEDGASEPLTSRRSSRRAIAPISSPLTDMANPRLEGKGKQGNARQQRESLPSGRRTSNRLAIQADVKPRKTRPMRSERTPVVEIPRLSPSERELYVAWGPSTQDTVPNDVTQTSVKPSEQPSSAKDSQQYDPSMIDDSDELDYQPNADNGVDLDLSSELTDQEEEEDGDRSLYQESGSDIRGSMTLKIRVGQEKVIEKQVGLKRHGVVSESDIDHWALESSETAPLSSNKRERAGKRGGKSAARRSGRTRKNIIPDSETSERDQSSVEDPLPKIPRIRLKRYAGEMQTEEEGEDEVDELQMNWDNDSESPRTKPRRRGRNNYSAPIPPSSPSSTPEHAPESTLAAHRDYCERCSRPPTAVIAEQLKTRKKKPGPKRKKVDEDDDIVSDGELVQTLGGWVTCKSCCIATHYDCLGGAQKKTLLQELHTSDVAAAVSLVQDPSQDLEALEAMRKTAENQVPKRKEVRIDEEVEFICARCNESGRCFVCWETGAEVHTAPEGKIEVDTQCAVGLSEELPKAPEELPNASQATGLGQEKTEQVKRVLFRCRRCKLGAHYEHLRPPKTLGGNPSLPDVALQYQTQTHDGNSWTCHLCRDFVWNVDIIIAWRSDSSCPLPANPTLNQPLFKADLPREYLIKFQSRPFRHVVWVPHAWLSSIAPQKLRRFLEKGPLLEIVTNATMTARGDELGVGPGGASIAKVLEMEGNNEQGFVGPEEDAESNLPELWSTIDRVLDIKLLRPTKEQINPKTRARETKQQRKRQRILSISPESDDTAAKPTAHLVEKSLFELAQEKFDLPDGMPPPIEEMVEIEEWEALMGRDVGEDDVDEIVGHVAWIFVKWEDLQYDQACWDTPPPLSSPFYPAFKAALGRFLRARHITIPVLTPAQALARDAKAAKGFVPPQDQPACKLMPFQMEGLQWLLYKHFKRESCILADDMGLGKTVQIASVLGYLGSAEHQIYPCLVVVPNSTITNWVREFEKWSPHLRVVPFYGEKIARQIIMQYELFHKGQQGKVAGLKAHIVLTTYDMVTGSEFKVFSTVPRWEVLCVDEGQRLKSDESKIFNKLKTLKSVHRILLTGTPLNNNIRELFNLLNFLDRGTFSNLKAMEAQYENLDEAKVQKLHEMIKPYILRRIKADVLRLPPKVEIIVPITLSPMQKQVYKGIFERNAEVIQEILRVRQKRSKAKKAARITGPTSEDTALPSVSTGAAGPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWK3</accession>
    <name>A0A1E3JWK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_01931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033896.1">
        <property type="nucleotide sequence ID" value="XM_019174089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWK3"/>
    <dbReference type="GeneID" id="30191144"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="443"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO05241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="609" mass="66577" checksum="402A39E9C377E571" modified="2017-01-18" version="1">MSNLLTKGFAVKATTLDDPSECFGAVLQVLNVKRISAGSESAIDRFRAIVSDGDHFCQAMLATQLNHFVEEKLVDKHTLIKVNNFSVNNVANRKLLIILDMEVVPGGGDEKIGSPVSIEGASKSAPAPQAAAPPPPAASRAANNSRPVAGRSGYGKGSKTEASALYPIEGLSPYQNKQARVIQKSDIKHWSNQRGDGKLFSVTFMDETGEIRATGFNDAVDNFYDKLEVGKVFFVSKARINIAKKQFSNVNNEYEIMFERDTSIEPCEDDTVPQVKYNFKGIGELGELQKDDLCDVIGVVKDVGDIGSITSKSTNKPFAKRDIQLVDQSGQSVRLTLWGKQAESFQGDDHPVIAFKGLKVGDFGGRSLSMMSNATMVISPDIAEAHSLRGWFDAEGQSTSFTAYTNSGISDGAGASASVKPTELKTIAQSKEEQLGMSEKTDFFSTQATIAFIKQEPFSYPACANKEGCAKKVVEDGGSWRCEKCDRNYDAPIHRYILNINVMDHTGSFWITAFNETAEQLMGISANDLMALKDDEEEGEGKFVSYFVRAVGRTYNLQMMAKQDTFQASRHINTRGAMLTKLDRTKKVALPDYVGESAHLTELIKQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWT7</accession>
    <name>A0A1E3JWT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033861.1">
        <property type="nucleotide sequence ID" value="XM_019174054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWT7"/>
    <dbReference type="GeneID" id="30191108"/>
    <dbReference type="OrthoDB" id="10314873at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="225" mass="25605" checksum="306DD42995ED0839" modified="2017-01-18" version="1">MPPTEQQYSDAGFTIVQRRGSVPSIILCQVCYGTDTNKAFPTSTYGSHIKGKKHLMHFPRWRDQRVHEEQEQIRWRGHYEHHSPYNLPRDQQQRPPPVTIPQRFPSDAPHTPSHLLPSSASASASTISPISPISPVDSHHGVMAGQQAMLSPPPHHMSSYPQMMGYPQYANVAPYQQQQVPQQYHHPGAVDRRTQYMVESDIGMGRMMWQQGYEDVQYGRTIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWY6</accession>
    <name>A0A1E3JWY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_02052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034014.1">
        <property type="nucleotide sequence ID" value="XM_019174207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWY6"/>
    <dbReference type="GeneID" id="30191265"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="400"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO05359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="877" mass="99726" checksum="6E93EBC11F7623E2" modified="2017-01-18" version="1">MSAQAAQPAQEDMAVVAPNAEADPANNAAHAPQIDEDSEMSEEEQPLKKTNGARKRADSSDEEEKPLAKKTKANGAAKRRVVASSDEESDEPLSQKAKRTTKKAAASDSEEEEKPLAKKATNGKSKVRKEIPASSPPAESSEEEQKPLAKKPARRASTKKAVKEESGSEDSEDEKPAKKKPAKRAPAKKVKKEETESEEEEKPLAKKAKAAVKKEVVKSEKGGKKKTKKEEEEEEDKYKWWEEQDAMGDGSSKWTVLQHNGVLFPPAYVPLPKNIKMKYDGVPLTLPPETEEVAGFFGALLETDHAQDAKFQENFFRDFKEIAAKFPPEEPVKIKSFEKCDFRPMFEYFEKEKEKKKAMTKDEKKAIKEEKDKLEAPYLFANVDGRQEKLGNFRAEPPGLFKGRGEHPKKGTVKNRLRPEDIILNIGKEATIPIPNVPGEWKGVQHDNTVTWLAYWKENVNGNTKYVFLSAGSAWKGQSDRAKFEKARELIKHVDQIRKDYTTDLKSKVMADRQRATALYFIDILALRAGNEKGEDEADTVGCCSLRYEHVTLQPPNTLIFDFLGKDSMRFHQVVEVAPQVFKNIKLFKAEPKKKGDDIFDRLTTSLVNKHLNSMMPGLTAKVFRTYNASWTFQQQLDKNTPEKGTVAEKIAAYNDANRDVAILCNHQKSVSKGFDSSFAKAEDKLRALKYQRMKLRLQLFAIDPKLKKKHKELAEDESDVDDEFIERHEEELLEKALETAKKKFDTDNVKAEKDDKPKRKKKDLEERLDEIKAEFKELKKERKSKKLEPKRGATEEKLLAQISKMDERIATSKVQLRDRANLKDVALGTSKINYIDPRLTVAWAKKYEVPLEKLFSKTLREKFPWAEAEAGPDWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ70</accession>
    <name>A0A1E3JZ70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034250.1">
        <property type="nucleotide sequence ID" value="XM_019173545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ70"/>
    <dbReference type="GeneID" id="30190595"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="309" mass="33532" checksum="DDEC7781C334EC44" modified="2017-01-18" version="1">MASERAVGPSTIPKDASIASLPSTSYPPIHQGASLLLALRLQDRPILLIGGGVVAASRVYFLLESGAHITLIAPLPLDPSIAHYISHPDTASQFTHLAREFKGREDEIKVKDFDLVLTAIDDNDLSKEVCEICREARVMVNVADIPPQCDFYFGAQMRRGPLQILISTGGMGPRAGAMLRDLIVDALPSDVESSLQGVGALRRDLRERAPGVGGERGQRRMDWMKQTCDKWGLAEMGRFNDEPTRTRVLEEGWEKGVVLGPSDLEGEIGSGWWKGLKGKVGPEGVWGVSGLALGAAIATTTTLWLSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1R1</accession>
    <name>A0A1E3K1R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034232.1">
        <property type="nucleotide sequence ID" value="XM_019173527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1R1"/>
    <dbReference type="GeneID" id="30190577"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="297"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="341" mass="36218" checksum="542925C3A411E141" modified="2017-01-18" version="1">MPWVGQDNNPSQPYIHNTYAPHLQQNYYGGVPPAPGIFNYSNAHAYGVDGWQQAMRLGLGNQQGSYNGGQPGHFYGNQQMIPFQTSPSQPSLFQPSLPSSPYQPSLFQPSLNQPSLYQPSLYQPSLYQPSHQPSSAPMTTRMQQTARKGKGAARRGRGRQGGGSSGVNANPAAAALKARLKKTARCSLAPEGQASQGCSNATTAIGMMWCWSTMMHMTMMSMLMPPNAPTYIDSIAADLAEQPQEQTPYSGDMFVKALHSESSAEDPKVGGKAGGAGQSARPMEGKQVGFGADKIGNDNVGHKLLSKMGWAEGEKIGKAGGSGIDMPIVAVVKNTRKGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1W7</accession>
    <name>A0A1E3K1W7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034292.1">
        <property type="nucleotide sequence ID" value="XM_019173587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1W7"/>
    <dbReference type="GeneID" id="30190637"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="504" mass="55040" checksum="38650148BB5BD6B8" modified="2017-01-18" version="1">MPHNDNSHDAYNALLPPAFIDDNPPPSRRFTVSPAHRVFLTILVTEFAFCLTDTTLLYAFKRMICDEYYKDHEWDHTGRHKCSVPAVAASYARSYSLAIGIMTVAAVVSVFATNSLITKYGPRKVFTLQPVSLFLCILIQTYGLSVGGLTGVHILQWSGLVYLFGSGAGLRIASNVLITRLVSEEERTGAFGVIDGMFKIGTALGYAFDGYLYDTYGLYAPFKTGLAMSVICIIVALLILPEVPEADRVSQETPSESLISPLKVFMPRKNHGPSGRRGGLDWNVTLLGLGIFFTVMVTGYFPRMLKMAGMDMFGMSAKTNGIMTSLNMLLEALFLTIFFPRVIKWGRSRAPAPPSSPSPLSPLPAQDSFDLYFLQASALYETIVTFITTLAQSSWQIFTIAMVLPLSSGLSPACTGVLVNLVDESQQADALSAISLVGWCAYLTAVSLFGTIYASLNKEALGRLIFLVNGCAVLLAFIMFILIRKRRVSRLPGAYVQLQASPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K237</accession>
    <name>A0A1E3K237_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034711.1">
        <property type="nucleotide sequence ID" value="XM_019172985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K237"/>
    <dbReference type="GeneID" id="30190026"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="34370" checksum="40DFD5E32F9E941F" modified="2017-01-18" version="1">MVRTIKLSDGKTLRAIGWGSGSGGIKGKDNNRLAIDAGVHALNANIRHIDTAQAYETEEATGLSIKEAGVDRSEVFVTTKISGTVANNKEAIKENVLGSIELLGFKPDLLLIHNPFVVEDGNIAKFWTSLEELVKDGTLEGVSLGVSNFRPQDLEAVLKIATIKPVVNQIEFHPYVLVHLEPVLKIAKEHGIVIEAYGPLTPVLRHPTGGPLKPVLERIAQRLSKDAGKELDSTAVLLLWTIQSGVVVITTSKNEERIKGLAALDSVPDLTAEELKEITDVGKTHHFRYYSEHMTEDFPDPDLPTVDFPKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K297</accession>
    <name>A0A1E3K297_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">F-type H+-transporting ATPase subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034775.1">
        <property type="nucleotide sequence ID" value="XM_019173049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K297"/>
    <dbReference type="GeneID" id="30190090"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="153" mass="16400" checksum="325FE12AD3D3C435" modified="2017-01-18" version="1">MRPQLAQAARLAGKRFNSTSAQNPNVQKAVESANKAYAQTAATVKKVAGPVGEKIGASLGAYREPIVYNSKVVASIAKQVYQAEKLAPPLDLNTWARAYSEIYHKATNGGYWSTLLKTGAWAGLGVAVVEAYGIFKIGEIVGRRNLVGYSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3J6</accession>
    <name>A0A1E3K3J6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035112.1">
        <property type="nucleotide sequence ID" value="XM_019173386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3J6"/>
    <dbReference type="GeneID" id="30190429"/>
    <dbReference type="OrthoDB" id="10460049at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="302" mass="33954" checksum="FA0FE47D21D17F0F" modified="2017-01-18" version="1">MELVSVPYEAERHKAEVTKEDRDDDIPLGREDIIVASFVSYPLDQPADLLVARQFDIYLGYLLIVSGTSPWEGHILYVHRFTFETVEEERGARSRNAHTVQRTTSLSLPTSPPVTRSVHSFGLGFKPASRRFDENQVFWNANIPYSDERVTSACTDWLDERALDARITFEKEEQAVRKKRDGEAKGQSAMTAQVFEDASKAARGLQRVVSQSGDVHALSEFNSLIQALGQLSAELHLKRNGRDEVPEAQLRATVATWAGWRAFDVATGNASLDDVRSFWDHHEAEKRVTSQNHELPAVFTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K577</accession>
    <name>A0A1E3K577_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035211.1">
        <property type="nucleotide sequence ID" value="XM_019172269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K577"/>
    <dbReference type="GeneID" id="30189294"/>
    <dbReference type="OrthoDB" id="10548472at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="255" mass="27566" checksum="47C1C4A2A0AAF805" modified="2017-01-18" version="1">MAYHKFSTASKYKRVVTGNNCPLDRQLRGIKASRHEFRVTHAREVAANEAARKASIARKVQHHRAEAQASQWEDVPMAPMDDYDMGPGDHSFDFVDERLKWLNAPSSGSVRKGAEVSIEAASTSQNPPTALPTSSTPASGASAAPSVEEGRPTVIPQVGEKRRRDDVDIAEIGVDNGGEKDVGGDTVGNTHKTSKHSPIPPDLDRTPQPSSSPSLTNDTPPVSEHEQKHRKKSERGADVDPLHPLSEPVQAVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K615</accession>
    <name>A0A1E3K615_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035385.1">
        <property type="nucleotide sequence ID" value="XM_019172443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K615"/>
    <dbReference type="GeneID" id="30189473"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="202" mass="21716" checksum="AAFA0FD848A14B67" modified="2017-01-18" version="1">MADLAAAFHAVPPVTRTLLLALAAVTAQVLFPAPLSLFWGPVARRFELFNIPIGLPFLFRPLLLAQTYVWCRVNPTVRVSIFGLFTLPTSLYPPALILLDLLTGGPAKALGGIVGLLAGHLWWFLSTYLPSHAPSHLRRANPLATPLFFKRQFPASQPMPQTVTGTGSGYTQATGHSTARSEASQAARHRWGGGQRLGGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6H1</accession>
    <name>A0A1E3K6H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035534.1">
        <property type="nucleotide sequence ID" value="XM_019172592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6H1"/>
    <dbReference type="GeneID" id="30189625"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="952"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1141" mass="122862" checksum="B4BCCF37EB894484" modified="2017-01-18" version="1">MAQLPLASPPPLPLPRQPSPLSFSSVSEDQGPSPLPSPALGGGSEFSSRLRQPSGSSHHSTPRVSSGTIPTTASQNAQLESLLPIKPVPDSLLFKHTLSALDSSASTFKRLSKTVLAYAAVAHTLSEQLEKAEDDLFGAVGELGRWLESGYDVQVKGEKSGIWEDDGIRKINKEKRRRERVETQVRVEQGLKDVKAHLKRRGLAGGGAQNKYETNAKQFYHATSVYLAPQSPPPSSSHTQQASASSTASHPAYDQAQAVRLAQWDLTRYTHHSMLLSAAPPSSEELLNLLVGLYGWAGAIVGEHPTAVLEGIDENSSTMIRRSSQSRPEQLRRSSTPVQTPQHLKTSLSSCLSQLAFTRSDLLAAWAQREEQTRLLQDEAYKRQTELDVWQDNSSNVKFGEGLELGLSQGSGNAMASVSSSGVEYKKPKKTKLGRSMGGRLREFLSPSSSSHSLASGSTTTLPSNMDRSSRASFDGARRETKGEPIRRSSTIGIDKLSTHKETPDHHIKSTPTLVATKSPPTPTSILPSASSHDTNTSSMPTPSASAHVAASMPPPPPPKTTARPLMTTRHSVHMPGADYIAPFITTMSSPTDYDASIKLPSPFESSPDLRLGISSEKLRHSLDSSRPLNFGPSPTPSLTQPEQSAIGLGHPTGASIGVGVGGVGGLGAGGDEDEQREEAGRKKEGVLWGMGTWEGLNKGAGGKGKWEKYWVVLDHSSIFEYRDDGSSGPPGGAHAAIDLRFAIFEIVTPSQGRRLYQATSDQEMKQWLYAICNAIESCINGTSTVRTIDQTKGRGPSGAYDDHALPTRSKYNLAFSGRSMGLGLIPNGRKSMPPTPVERDTAEPRTRKTSLKKVLKSSGERFSTAMAGGSGSSEHPEKSKRNSFGGLEISRPVFGKGVNRQSLPPSAPETASRHAEFSQSQLLPSISTPPGVKSSWADGEIEKRVLEMSGLGLGSSPTTATRLAPGESPTSAKRRVKSEAVRKHSQKHQQGGEGMTRSKSDDGQLEEADEKRVLRKIAAEEGNSRCADCGGGMKASRWATISLHGKPIVLFLCIRCIGIHRSLGTHISKTRSVDMDNWTLEQVASAREWGNIRANTVWEALLEGGRRPASGDEMKAFVKSKYSDGKWLKDEDRARFGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6W6</accession>
    <name>A0A1E3K6W6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035666.1">
        <property type="nucleotide sequence ID" value="XM_019172724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6W6"/>
    <dbReference type="GeneID" id="30189757"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="106766" checksum="82B34F57A71718E4" modified="2017-01-18" version="1">MAPCPPPPSKASVHPFFSSTPQQSNRDPIPAQAKPANAAPKRKRALGAANASAGPAQATLGLSSNDGGRKSLVVDNKETQPTVVEAEASHAATEVSSSSDHEEDVVISHASQNDPDPSKSQTVSKRPRPKRARPSIPLSTQASSSSLASEIIDLSSDQEDDYESTPRAKAKAPHMLNSRPAIFSKGIARSFSRTGSTGTNPEAPIEVPEGSPSPVKMRNTSSKNTSSVADKGKPAHSFFTQVRSRTDHDSSSSQILDPVEPLSGRDGAPYEADNGFKHKKKENVHTFFSLQQGKSEWKLKDGWGTEEVETPLPQGPWPSHVGSSYSQSDGPMLPSRSRKPAPAEQGNFWGDIQSRVCRPCAPSIHRSEPINILPFILQHPAFSSLQLKASSSSANREAWVDRYRPKRATEVLGNELEATYLRDWLSKLAIGHRIQGPKIIRKVVKRPKAALVDDFIVDDLGVCGDAFDEDKEDEQIHLDDLEEPPIDSDITARPAEYPPLDMRLTNTILLTGKSGSGKSAAVHAAAQELGWEIFEVYPGMGRRTGGALMGWLGDLGQNHIVPQAERKPAPKKSKKGRGTEVKKSKAGGIKSFFDQNFRSKPTSSVPFSNDLTQETTDSDEDDPETKDDNVAASTESKYKQSLILIDEADILFEEEATFWPGVLALVSESRRPVVLTCNDHKRIPLAQLPLQAILQFHPLPSSIAMSYLQAISDAEGSRRGYRVTADAATVYKSAMRDKHETDIRGDGPALPNGHERVPYFDLRQAIGQLQLGLQADRIEEAGSAKECEDDLKTLFQRMEAQSCADVAGMKPWVSMDISDIDRLERTSDDELNVSLLQKSAPPETYPILALCDQSPAIVSTVVSMSGGGLPPMGDLGLARTKYIRSTLPVLDPLIPLSSPLLPSPSIFLHTLPAIITILLFDAMYEKIEKDAIERGEERINPKTGKPMRRQQGAVYGRYWDLGGAEEAVEEISRLWLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6X5</accession>
    <name>A0A1E3K6X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_00010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035144.1">
        <property type="nucleotide sequence ID" value="XM_019172202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6X5"/>
    <dbReference type="GeneID" id="30189225"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="315" mass="34601" checksum="A8841163C9C8C5F0" modified="2017-01-18" version="1">MSAPVSSFRTLLASSSRSLRPTLKPRIQIRPSSSSSFPPPTGPRFTTAKPKSEWKKPTTILLIMVPFVTGYLGWWQIQRLRWKLDLIDEVDRNMEKPPMLLPSHINLAAIPDFSFRRVLVKGQFSGPPILLGPHTYDGIAGYHLILPFHRSDGGSTILLNRGFITTTRATAIRNRSQSVPGLTADGQSTGEEVVIEGLLPKTGEKSGFTPDNKLETNEWFWKDVDLMAEVAGGSEQNVQPVLVDAIAEPEISPTLLMQQGTPVGRPPVVELRNQHAQYAAIWLSLCASTTVMVGWILTKGRAGGKGSAGKRPKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3H9U0</accession>
    <name>A0A1E3H9U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_08298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000068">
        <property type="protein sequence ID" value="ODN73107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027757.1">
        <property type="nucleotide sequence ID" value="XM_019180263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30197508"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013380261" description="3-hydroxy-3-methylglutaryl coenzyme A reductase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="307"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN73107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1285" mass="136897" checksum="C663E8A43031A4A8" modified="2017-01-18" version="1">MLRPLLISLSSLASAAPIEVITTTFILATLSYFQLLQAVKHSDFFNVPAVSTPSRPAHLVHLSHQPQVQVEDAPYILPSSHGGSWSNAASGSGGSEYAGAGDWQPVTATEFRRILEENALDGGYVFPVEAGGNTAGEKATVAIVKQIVLTREGTEGSTDDWEKWLLNDLSVTYEGSRYTYRDLCFNSSSVPSFTPHPLHPSQSTITLFFQPPSPGTPTIPFLHKLNHITPYHIPGSNSTLRLLPPSGSSWGFLPSIDGVGLFSGLGDGLNVGDEEPYAVQNAKWIAFAMSALVGRIWTLAMNADSADIFVVLLGYIVMHGVFANLFISMRKLGSSFWIPIATLCSSTAAFLVALHAAYLLDIPVDPICLSETIPFLVITVGFEKPYQLAKAVLQNPDIDPVPSSPALSPTDSSLGSSLGLDLDLGALHKELAPLERLQRLAEGKVKWVAPVAARKIVVDAVKNNGVRIVRDYALEIIVLCGGAASGIGGLREFCWLAALIMAVDCVFLFTFYASILSIMVEVHRIKLIGGNRRVKSVKRVSSSTSLADGASSSPTVKGFWSRSTSPDKEDQPENPVVRLKLLLILSFLVLHILNLCTTLTEQTSLKRHSTHSVPQITSRALLDPRSASLSPVLQVLYDNQPAETDMAIQIIPPTQIIMSSDNIVPSRMSSFDHFMSEWTSLVGDPVVSKWIVVFLGISIMLNGFLLKGIALNSMGGKGPVAAAAQALVGIFDAERGQRALRETTTTPRGRDGALPGTALRAPSNGNVNVRDGDSTPRVDDSKTNGTIPIIREPTAPSPPCPPSAASASPDDGIITFGRRSLEECIEVYAGGVGVNNLSDEEVVLLVQKGKIAPYALEKILKNLERAVRVRRAVISRSSFTKSLEASLLPMNDYDYKQIIGACCENVIGYLPLPVGIAGPLNIDGQLLHIPMATTEGTLVASTSRGCKALNAGGGVTTVLTHDAMTRGPAIDFPNIVQAAAARIWIDSPEGYGTLKAAFESTSRFAKLQTLECALAGRTLYVRFAVQTGDAMGMNMISKGTEKSLEVLRERFPDMHVLALSGNYCTDKKPAAINWIEGRGKSVVAEAVVPGHVVKSVLKTTVKDLCNLNIKKNLIGSAMAGSIGGFNAHAANILTAMYLACGQDPAQNVESSNCMTLMEPINDGQDLLISCSMPSIEVGTVGGGTILSPQRAMLDMLGVAGAHSTTPGANAQRLARIIVAAVMAGELSLMAALAAGHLIQAHMKHNRSAPVTPGAVTPFGGITPLRESVLINGPPPKKSDELRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HBB3</accession>
    <name>A0A1E3HBB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000064">
        <property type="protein sequence ID" value="ODN73627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027773.1">
        <property type="nucleotide sequence ID" value="XM_019180243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HBB3"/>
    <dbReference type="GeneID" id="30197488"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN73627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="165" mass="18829" checksum="D7BF6C2BF511FE9D" modified="2017-01-18" version="1">MKELRIEKLVINISVGESGDRLTRAAKVLEQLTGQTPVTSKARYTIRSFQIRRNEKIACHVTIRGPKAEEVLERALKVKEYELRRRNFSETGNFGFGIEEHIDLGIKYDPGIGIFGMDFFVVMGRPGMRVARRKHATAKVGSSHKVRPEQTVAWFKQRFDGIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HH52</accession>
    <name>A0A1E3HH52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_08137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000054">
        <property type="protein sequence ID" value="ODN75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027918.1">
        <property type="nucleotide sequence ID" value="XM_019180108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HH52"/>
    <dbReference type="GeneID" id="30197348"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF289">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="126"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="341" mass="36944" checksum="92963A96559CC2C2" modified="2017-01-18" version="1">MTLARGSKVLFLDSIKLAKTQLAAFQKVATVVPNTSTTREQFISDLGTKYKDVSGIYRHFKASESIKITGRFDQELVSKLPRSLKFIAHNGAGYDQIDIPACTTRNVQVSNVPTAVDGATADTAIFLILSVLRHFPLALAHAQAGTFNSALPLSNDPKGKVLGIVGMGGIGSALAVRAKALGMQVVYHNRKRVDAGKEKELDVRYVGSLEELLKTSDVISLNLPLTPSTHHLISTPQFDLLKPTAVLINTARGPIIDETALIQALKDNKLAGVGLDVYENEPKIPKELLDDPRAVCLPHVGTVTVETQEEMEAVCLRNLETGLRTGKMGFVVAEQKQLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HRL5</accession>
    <name>A0A1E3HRL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_08010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028044.1">
        <property type="nucleotide sequence ID" value="XM_019179983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HRL5"/>
    <dbReference type="GeneID" id="30197221"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN78091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="160" mass="17990" checksum="88A7A55738019640" modified="2017-01-18" version="1">MSALRTSLVRSARSLPSSSRVVAFPRQAALQQLRPREAIFRRWNSSANHNPAIEAPLPGSRPQKIAQIEPRLQMTFTCTADGCGHRSTHEFAKRSYEKGIVLVQCPECKNRHLIADHLGWFKESLEDGKLKTVEDLLRAKGEKVKKGRVNFDGDIEIDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I159</accession>
    <name>A0A1E3I159_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028295.1">
        <property type="nucleotide sequence ID" value="XM_019179748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196971"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="738"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="932"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1389"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1389"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1447"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1482" mass="166048" checksum="8F549B8BE7EEA28C" modified="2017-01-18" version="1">MGIPKFFRWISERYPLTSQLITPNSIPTFDNLYLDMNGIIHNCSHPPSSENDPHFRITEEQMIIAIFAYIDHLFTKIKPQKVFFMAIDGCAPRAKMNQQRSRRFRTARDAREQRLQAEKNGEKLPEEKAFDSNAITPGTPFMARLSEHLKYYVRKRISEDADWRNIKVIFSGHDVPGEGEHKIQEFIRLNKAQPDYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVVFGRKSKKNTELANANFFLLHISLLREYLNLEFSSLQHEIPFEYDLERIIDDFILMAIFVGNDFLPHLPDQHINEGALERIWGYYKELLPTIDGYLNEHGTISLPRLQLLLDKLAAYETMKFEEDLQGQVHYSGNHTKDTVAIEKARKKGKKGKTVITKYQKKILDQIRTFVQQHQKKPTDTKRLTLVDTKDQRDNAFIQEVGDELHLRVTWDEVDDYGQNVIALTFDMEGVSQNGSAKGENDSEESETDEEDEGTQAIQRVFAKWNKAVIVDTYPEEVEQSMDARLKEAMDNVKKTYYHDKLEISYENPADMHEIVHHYIEGLQWILNYYYKGVSSWGWFYKYHYSPRITDLKGIADMKFEFDYGKPFLPFQQLMGVLPADSQEHVPLAYRDLMYDPTSPILDFYPKDFELDMNGKKADWEAVVKIPFIDQNRLLKAMAARDHRLTPEERSRNQSGVLSTQFVFDGELEENYPSSLPGSFPELTRCHCKASPFNLPTLGNGVNLILGLLDGVHLGSSALAGFPSLNTIPHQGALGFHGVVVFQSESRNPSMVITVTDKDERPKTTEIARATIGQRTYHTWPYLQEGLVVAVSDDMFKCEVQQMGHVAKIVQSPHHGADAVKWKRQADNVERHYGRRYGVITGPVEVLLHIRPLKGLKHLDNGALIKDYEGPEKEIVQAYQMAVSNVAFEDERFLEQGPPDLNIEYPPGENVFFLGDVNNNYGCAAQVSKINDKTQTLDIILAYFEGESRDNLAFRDLATQRPSSKWWPSPTLSRRLGISALALSRITSTLLVQLEDGSKTNIGLPLKFESRGLKVLGFTKRNDRGWEYSEKAAQVLQEYKEAFPEVFAKIENRSGDLAKSLELCPSADDPDGVIKAMKKWLKERDLVDFETVSLFADQLEKETCEAIEKLADHLYAHKAQSQQQIKKQLLRSVPRQSLLKPAQSIYRLQGQVFEVGHRVIMVQDPAAGGVPAGMRGVVVGLGAKSVDVIWDTPFMGGTTLQGRCSEYRGSSVPFSSCLNLTRRQFMITESSAPKPVSQSAFKPQFGPRPAVQGPNYQSSTVARQPPSAGNKTLFDPSSAVKPVTARSGVAIVGTNGHLHYGNAAKGIKPEVEAPQHVSHRDQIANLLGGGFKLSQAPRPQFSHPASYAPAQGAGIHPPGNAFAHPPPAFANRGGPPARGRGRGRGGFNPAVNPAGTHVHTPAAPFNGNVASQADGAGRGGARGRGGRGRGGFVRGRGRGGANGVANANGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB81</accession>
    <name>A0A1E3IB81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028567.1">
        <property type="nucleotide sequence ID" value="XM_019179426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB81"/>
    <dbReference type="GeneID" id="30196637"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="77" mass="8607" checksum="204F96E4ECC46626" modified="2017-01-18" version="1">MTAEEPDKGRVEKVVETRQEVEEAENLPDRDVASEPTIRVSDLPPLFDMIRKITAKVLSATLQTQRNISARAAQMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFS8</accession>
    <name>A0A1E3IFS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028989.1">
        <property type="nucleotide sequence ID" value="XM_019179071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFS8"/>
    <dbReference type="GeneID" id="30196267"/>
    <dbReference type="OrthoDB" id="10299345at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="189" mass="20889" checksum="03EC1D7171872126" modified="2017-01-18" version="1">MSEGKREEEEEDWAIPGGFSLGYGPSTFGSPTEDTTPAPSESRNEPDTAPLDRSANTGGGAESRVGSTQLTLSPTHWQEMRQACHTFIQEVEQQPEYDVAPTDETTKALAALNGTTPSNLNPTFSEQSVVAASHYDTWHPPFRSFERNGKPAFDYLTAKTLFSCKEEPNEVVWLAKYSVSVARLRSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGH7</accession>
    <name>A0A1E3IGH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029042.1">
        <property type="nucleotide sequence ID" value="XM_019178948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGH7"/>
    <dbReference type="GeneID" id="30196136"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="6">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="1227C72A8DC4882E" modified="2017-01-18" version="1">MSSNSNTILRCTITNIGSTPGREIIQTYVSALLSSISRPSRELRWFVKTKLSSPGKVKWSASVSIKRLSHITGRRGGQWKLEKDEYQVLVGASSVDIRETIEEDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IH46</accession>
    <name>A0A1E3IH46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029088.1">
        <property type="nucleotide sequence ID" value="XM_019178994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IH46"/>
    <dbReference type="GeneID" id="30196186"/>
    <dbReference type="OrthoDB" id="2573025at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1128" mass="123401" checksum="9C3CD2ED9332E153" modified="2017-01-18" version="1">MARPQPTDSYGEVFVDSEPSEPDDEADEDYAPFSTAKLQRWSSKRHSKPIVKGRKSDGQRVAREETTREPKHAQRERSASDNHPSIPQGPSTLYSQTYLGSILRQASKGEAYPPHPPALQLNAANYGGEAAVQSDMYDCRPSLQISTTEPIIRSAPSSSKPSSSSNPLLSNQSLYALQDGQSARVPVHHPMETTWGQAWPQLGTQAVGARPNPLNVDLAAESLKRLTSLPSRSMFQPSKKAKEDTSPPEASQSAGVNPNDLKLPSGSSPLDGPGSTGSMVDHSVMSGSQASVGSVFSSQPPVLAEEALQRPRLSLPLLSRDPSSETTVTQSDDDCFDMQQRHQPFAFYDSSASSQQSSQLQHALLSKSVDPLSSVTSTNFAFDFRPSTANSYTSFGPSEASSLAGPEYAASPMASMPPHDATGQHYSPYGVLSQSMSGRPATSHGPYMMPSFSHQMNHYAPSFAAPLPSWMQPRLQQQAPSPHMSRPQTSLPLSSTFSSADWRQRLGKRRSQTLPPEPTAIPGSGTYSDMYGTPSMFQAPFPIGERRMSYPGFGGGAKYGQGLGWAPNIMSTSFMSSALAPAQTPGESLNSAFDNRSQSLSQQQATILHPPPFASPSHIKRGHRRPVPGSNQQTAYPPFSQPSVKQDQPRSLSFSHPKIPTSAQLDTRRRSMGSGPTPKSALARAVFFDEPEITETEVAVSETEGEDDEGESDQNDDAEYEEKSGHVSSSSEDEPLRLSSRTSRASKSKAKPKATYSFSKRTRSSKSRSKSASHGSRPKTPMDMSETHGQMVCACPLMHMARPADGDNAEPHLCTTKVTANRLLVQGHKLCSYCIGRDGHVEEYVKERTRTKTVDRLCFIYVIYRELKIDQTHGEGQRWQKYWEHHRREPVDEEYGKKMLASWIERMETEKRNWEKHQERAAKREAQAVKASESTRAAKAKADDEDKMESMEKEVKARAKSRSIASSLEPDPADFASIPEPKSVSVSDSSTSCDDWAPNPYTHSSTSLAIPKRPIKRGQIKLEAQPHRPTHRSVSTPNPAIKNSTTMTNIPNSSSPDSRISASPLKDKFWSMGSAAGLAGVADVEKWDGRVSLSLTPPPAEERVESKEVRDWDVDEAVWRALSSSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHG8</accession>
    <name>A0A1E3IHG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029107.1">
        <property type="nucleotide sequence ID" value="XM_019178830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHG8"/>
    <dbReference type="GeneID" id="30195990"/>
    <dbReference type="OrthoDB" id="2570740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="531" mass="58715" checksum="F6AE51F9AF3D451F" modified="2017-01-18" version="1">MSSLTDFYPYAFSDFFGSGTPCVYKTGPAWPIAREQKIVRAARPIYNHPIAPTWLETAWAIVAQLDLLQLNWNTVNPLAYANAGEAALICDFVITIGVQPRSLAYPAAVAAAQAVVEILEAAGFPEIQVAFIESVYRRHMSHPKRMSFNPILDSEGLPALRKPFTPTLSPSIAPLKSPYYEGSGGLYFRLNAEEGDNRVALLTCAHVAHPPPVSENKVYTRRNDSEAREEIILLGTGSYDAAVATIMKFINDRTIAITSWETARGSLPAQRDGEPKGVTSKRKALTDLIDAASNKIEKANQLHTDVTKHLTTTVSRVIGFVVHCAKIEVGEDQFMYDWSLIQMDEDKTEWDDFKGNKLFVGGNKTAVDWVNYMFPQEFKDRRGFHAPEDMLLALKDVVPEAEFRNPQNFDIHNVRTLLAVKNGRSTGTTFGRVNGLESITRHYPEHGIAQRTLEFIVCGYDTVRGKNDKFSDDGKSGSIVAGRDGRIIAQITGGGGPTDEADKTYVTPFYALQGAIKKKYPNCYLVPATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHH9</accession>
    <name>A0A1E3IHH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_06793</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029117.1">
        <property type="nucleotide sequence ID" value="XM_019178840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHH9"/>
    <dbReference type="GeneID" id="30196005"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="171"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN88049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="687" mass="73651" checksum="5130185FF08B5CF0" modified="2017-01-18" version="1">MNAHSPPLPNLHALSLDTHGPGGYTHPPQHTYRYNAVFGPPVGMPQPAGSPDWSSKRSSRSGLPTNWYDPNEYRPASPPATLSPPSSAPTTAPAYPYQPQPSYPDGSYGMPLGMVDTPSPPPMGYPPMGFNGGYPVDQRRAQQQAQGQANGWRNGYAMPAIPHQDDDVIPTAIVIKNIPFAVTRETLLGVMESLGAPLPYAFNYHHDNGVFRGLAFANFRAPEEAASVVAALNGYDVQGRKLRVEYKKVLQPGEKDKIEREKALKRMRSLQFDREKMPPPLNLPIRHQQVPPIPYDQSPPHSASAASTSSADNLPPLDMNDPATLDIYSRVLVFKEDRMRDELAFSKNLTPQERRIVHSVAQRLGLSSRTRGEDDQTVVVSREPQPRPQLHSSTSLQNNYYDPSPQSSAPEVSPNLRYKKSMPDLRGFNGPVVSRDPSRSLTPQRSSGNIREMGREYASMGAAGGRQASRQQPSNPQYGGAFNGLFGHSIDIPPVPPLPSGMGMHNKGHSVSSISGISGQPHHSHSHSYSQSNQAFSSHHSNGRASPEDLLSPISSSSLSHAQSLPNNNHNNATQPVRNPRGPAGESRGFSQTLRPVASRGMMGPPHLPHSSGSAGSSGGSTGNSTSAAGLSSSLPRDLGREAAGTIGEGPGSVSSRRDSGSVKSGTGSGSGSGDEGIMRTRESLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIG6</accession>
    <name>A0A1E3IIG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029201.1">
        <property type="nucleotide sequence ID" value="XM_019178718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIG6"/>
    <dbReference type="GeneID" id="30195875"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129775" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="16783" checksum="13A97B38F1F2D2D9" modified="2017-01-18" version="1">MKLSTISLLLLPTLALAAPSENGALEKEGERAVGDSTSVVSLNDDSSTLSSLVVFNPSSSAAAAAASASGSGAGSSAAASSAAESAKTITSGESLAFTPGASSTSTLSFIGNVSTATGAGAGAGATSAQGSGSRVAAAAGTTTATGATGSARSSSGAVVGRGMAWGWGGVVGVCVAGLMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJP6</accession>
    <name>A0A1E3IJP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U4/U6.U5 tri-snRNP component SNU23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029385.1">
        <property type="nucleotide sequence ID" value="XM_019178684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJP6"/>
    <dbReference type="GeneID" id="30195841"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="263" mass="29945" checksum="4643104481C2372C" modified="2017-01-18" version="1">MADKPKTSRPTWDKSEYSTLAKDKDRQSYEHAKEAESSLQSGKAPGKKSQYDDLPKPTELLKAREQDLGLTKNLNKTMLVSMGGTGQKGPRGGGFYCELCNRTFKDSLSYLDHVNGKLHLMKLGQTTLVHRSTLSAVRARIATLRAASQSSVTSKNFDFQQRLKAVQDYKTSERERKKAERQKKREAKKEEEERRRMGIFDEKMDVDPKEGEGVKEAGKRDRKKERDNRRAKEGDQEVERALQENEDMSAMMGFGGFGTSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKU6</accession>
    <name>A0A1E3IKU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029508.1">
        <property type="nucleotide sequence ID" value="XM_019178601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKU6"/>
    <dbReference type="GeneID" id="30195758"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="257" mass="28132" checksum="AF955178D4EA05BB" modified="2017-01-18" version="1">MTTPTDVTRTFGDCIEILWWGWNATVYQNASGMLLGRGVPNPLVHEEGGRDQVDAARPIKILGFRHPQAFLNADGYVVAMENGTTSIRSWDDVVVTELGACYAYQKGLGVFYFDTLNHLLLDQNPFGPFKHPLIRQDTPLKLYAAESTVYFLTQHGTCHVLEAVDARALPPALKSTCPDPVQIQLVEELEGLGVTHIVPGSSNRFAALTEAGDAYILAPKMNLELLDVGDDVRLVGVGSDFDVVVTKDKIFVRGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM78</accession>
    <name>A0A1E3IM78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029613.1">
        <property type="nucleotide sequence ID" value="XM_019178457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM78"/>
    <dbReference type="GeneID" id="30195607"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="411" mass="45042" checksum="8CC336739F2BA682" modified="2017-01-18" version="1">MPVHSLASAVGDISTSHLLVAAATFLVIFSLKVWSGGKKNTWEREWAGKMILIVAPPTPTILALIDQLLHLPSPPQILFLPPIPSPLPEELLTLLHAIRLSAAKNPVAQLHCESLPRSPVAVRDFTKKWASVPTGTAGADGRRIDAVILGEGWEIRPKELKLQSQWTTHEFHYHLLTSLLPYFLRAPSERSIRVISLVSPAWASAVPSLKNAEPREDIVFNTGRRSINTVLLMKHFQLILDTLAAAALGMVKPVPGTADEEVTKKRDESVKSNIMSLSVVMPWAREEVLKAAIVESLLSKILWIVFYPLIIILTPSPAKAAQTIMFALSAPVRYAAIDETPKVKDQGKELDEVRRAAVGGGDVVRDCEVIDIPPVLRDPALAKATYDALEKQVEAGVKDLESREKASTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IN83</accession>
    <name>A0A1E3IN83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell polarity protein mor2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_06483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029446.1">
        <property type="nucleotide sequence ID" value="XM_019178539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195695"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="396"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1756"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1988"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2408"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2429"/>
            <end position="2441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2558" mass="279900" checksum="2CFEA5226D79F8BD" modified="2017-01-18" version="1">MEEIVIPNLEDDEDDYLPSHSRPVFGAASSTTSLPDTDPYSNSHRSNLSSDSSYAPSKLQTTTPTRPGLQKTSASFSVGAPTLAHGFGQQQTPGSLGKFNNASSSSLVTPGTSISSSGAVRRPGLATKGSFASIKNAFKQNHSTPAPPLPAFDRTGPPGYPALKNPFSRYDSPMSPRNPAGFKTPVKGKNLSSSTTASPMSRGNTADGQGRKYSIASSHRSQGGRSMTSNGSVNFRADDHPMPALPPIPSRQTPSRLGGRHGSDVGSYLGRMRAGSVDLDDGEFGRTPGEEALRVVFIEFREAAGNKVQRVCARPLNSHPSLSTILEAGIDPQFDNTITSLSQSATRHARRVVDLLISWCRDYCGNIGASEVRSHLDRSMGLQMKVEDAAAILQARKSSAARFIMNRALIELLKIMPKDSLDQELGMTLENNAFNAYRSEKPEDVMQFPHKKAVSQLQIQLLGQLSKTRFLTVSDRFVRELSKYATNQQPTKESEARIEHLLKGMRHLQLKVYPEDELEMSAEFIQSLSAFYASTHGQSLKIAYAETFTHLLHPVIETATAEVNHPVWAQAMAVILDRALGMVGKARYWNAAFPLMVTALGASPREVFIQQWQNVVDAIMAKFKDRNTKSVAMGAFIRLLWVYLHRCHESSTSTRKRLDHLIRVLFASSQYLYPSEIPFEGFIAVLHYVMTRQTDYGEEFVVEFLGARSATDSGAERSTAVVKAVNLTLRVIELEKHATWPQSPDFTNFDHDSFAFESSGETMPFDTETKPEVSDLLKKAGPAFMNLLVECDNDVRNLLLSNDSVAIAGHASSNTMDNPVEIITSKHGDVYVSYPARYAGKMRLMEAVMEALPRCLPKDPKWAELASILCRATFSADPNVCVAAGNALKRMAQDPQRCLLLVATYRGFVFETRHIFKDTFVGAKLMDSHFERVVKLWLDMLLLLVGHQRVAEAQADDEDGQKAPTADASQIAQIEASAIFLLCSSALSLRKLAGQILVAARDLESQQRLPSAAFRYSRLVPDKPASAGHVLDIYEHVLNEKDIDALNQIPWLSQPEKARLEIVINNRGKEGGKLLQRIAEGESSRDAVLWLSVLPIFISRVADRLPKVSQELRTVVGGLVLRLQAHVALVAGGVMRGTPNRTGGSLATRSSSDIAILADHWRAYLSILCVTLNPANGPAPSTPPVQRSNAKDVIILNQEAISTPVLFTYLTSLLGWEDTRFKDAAVHALGSIRQGMMRPLAEQLLNVTRRLMDGAKVGTAPREGTTKKTPNSTIWTAVAHIFRLISPLILDHKSSNHLTNLSSMIGFIKVTWTLLSDRTVKEDYDLQNLRRSFCIVVENLTNALGKLDSSDRFLGEEMRGAVFKLCYEWCLVGRRPDVAKARESQMLQAAAGGYRGERDRASYLDNLQNKTKLLSMAAAEAMAGLCQGKLISVSDSTPAQQASDHIVEPLLVLRWIRGMFGSANMSHNATAKRALFALIKYNWDCERLLDEVLHQSFGEGEQFTLESSFFGVVADLLSEGHLDLPVEQVACLALSKLGHPVSTIRQRAFQLAQSLLSHPGDMLVFSKLLPSVGSSSAAIYRQAQDAISGQLASIYADNAFSFLSECTTRLSQLEAPRRQATLSVIRSWVQYLDMASDMSDLSPEDASLQHQALHNLVYLGVRFGEDHPEEIKVIVLSFAGSSSSQNTTALVKFLFEQGGKRKSPDFVEHAQRMVACLASSSAGDNIFEDICNFVEPNAMVALPEADVPPSPMSSLANLDTIMSAPSARSQTFSTGQLALVFAGELLPHRLSDSELSKKLPALLQAALIQCDSASSALRDQSQTVLFQVLRAWISDVSLVSPQDAHAIWASAETKVTALAMKKQGIFWKSDDNGGSDVAFMAPPKMTDLVIKILGILLPLQPRIRQQWGELALSWATTCPMRHLACRSFQIFRILSPNVKPRMISDTLARLSSTIASSSQEIQAFNCEVLRTFASIVQSLGPTEAQSNPQIFWCSFACLTTPYENEFSEVIDLLSHVLDKTNLSDPNVVQLLNKYRPADWVGPAPYLQSLLLVGLRSSKTSFMTFDLIRRLTSASIDELVDAPNDRLIHGFIAALPWMLHSTYLGEPNEELAEMALDLASIADQQGRASFSRLLTSFAKVRFRSKDDFIRQAASLLRDYMPTHALGIVTLLLGFVLNTHDWMREKSMQVLKLILQSPEARAPLQTHGNELLQPLLNLLSTKHATQALDVLDMPITATTAASVDNHAPASPSFSGDIFGLVEESGWSVPRAKELSSLTRENVRAVFNTCTTETRAASAHFSVVQFADMRPFDFNASQVSLDLPSSPPINGEGAMANASIGDLVGALHSLGHFFEDGDTMAGLGNGTSSPLPNYNMSRHAASNSDVSERRVRAIMARSHQHQSSITSPIYETSPAHSRINGRPFRHNHTRSDTIASESSMTSSSMDERENATQRLNFSIQSGGSSTLGSLTPVKSHGQSHSTGSVNIPLGVSESRRIHLPNDSMSSMSDIGDQSAFGLDEEAAASSMGGLPSTTSMTSISSAAGYGVAVGRQGGWNERERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ77</accession>
    <name>A0A1E3IQ77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029856.1">
        <property type="nucleotide sequence ID" value="XM_019178137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ77"/>
    <dbReference type="GeneID" id="30195282"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="531"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN90754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="683" mass="76911" checksum="62EC4DCC01525E59" modified="2017-01-18" version="1">MLRARPPAGLLSQRLSVLRPMPPQASFRSFQPKPIPVQSLVVQQAKPRFFHSQHRPTFRNAQRGLVLRSLHIPSFPPDSFVAKYPYFSILVRLILSSVLGLVVLTGVILCHDAFTYSERHVDRVPCNPLALTPRRGGKKNLPIIEANLDSEEDDTKRAMRDKPRLVIVGGGWGAVALIQSLPAHAYNVTLISPQTYFSFTPLLPSACVGTVEPRSLVEPLRKLIARVRGHYLMGSAVDLDMAERLVEVEVRGDEGKPPSRCYIPYDRLVIAIGSTTNHHGVKGLEHCYQLKTVPDAQAIRRKVMGNLELASLPTTTQAERKKLLSFVVCGGGPTGVEFAAELADMMAEDVLKYYPKILSNEVNVTVIQSRDHILNTYSEKISQYAESRFARNDVTVITNARVQEVTPDQVTITVKDPKNKEAKPETRDIEAGFVLWSTGIAMQPFTQRLVEVLPNQYHSKAVEVDGYLRVQGAPMGTVYALGDSATVQTNLMNDLYHLWDKFDINKDGSIDYDEWQQMVKYIKKKHPLAHRSLSKMRDVFTEYDRDKDEKLTLNEIAELFAHLSKKVTSYPATAQVASQQGKYLGAKFGKLAKQRETLAKNGIMDLDDEAYYKPFEYMHLGSLAYIGNSAVFDYEGWSVAGGLLAMYAWRSIYWSEQTSMRTRLLLMLDWVKRGIFGRDLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ78</accession>
    <name>A0A1E3IQ78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029862.1">
        <property type="nucleotide sequence ID" value="XM_019178143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ78"/>
    <dbReference type="GeneID" id="30195288"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="36" mass="4050" checksum="8655F4375AB7BD59" modified="2017-01-18" version="1">MSSCCRRGGGGGGGDYLQMYKWHSNKWHSTRSHLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQL2</accession>
    <name>A0A1E3IQL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029817.1">
        <property type="nucleotide sequence ID" value="XM_019178098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQL2"/>
    <dbReference type="GeneID" id="30195243"/>
    <dbReference type="OrthoDB" id="3597994at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19262" checksum="A9074B7F4C595608" modified="2017-01-18" version="1">MSQPSTSQAPQPNDPPVDSPTSQTNTSLHRAKVNASYLLFGSAAAVAPASFATRSALTTTRYALKYIIRRLLRYTKYALIGGAVAALGGGLIGTLGSGLAFFAAPGIGVGMGIGVITATVKFGWRHRGNHFRGGIWDGWAGMKERAAEGRDPAQDEENDAKGTAEQVKVENQAKRADVWMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQW7</accession>
    <name>A0A1E3IQW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029937.1">
        <property type="nucleotide sequence ID" value="XM_019178218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQW7"/>
    <dbReference type="GeneID" id="30195364"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN90835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="251" mass="26855" checksum="CF2A8E1FF35C6493" modified="2017-01-18" version="1">MSSNLKGQNAVVTGGGKNLGALIAQTLASQGVNVAIHYNSPSSKKEADATLEKLKKTGVKAAALQGDLTTEAAVEKFFKDATSALGVSKFNIAINTIGKVLKKPLLETSEKEFDSMFLVNSKSAFFFLKHAGKNVEDGGTILGIVTSLLGAFAPGYSTYQGSKAALEWFTKSASKELQPRGIRVNAIAPGPMDTPFFYPEEEDAAVEFHKSQALNGRLTKIEDIAPLVDFLVKDKWITGQIIFSNGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRY1</accession>
    <name>A0A1E3IRY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029965.1">
        <property type="nucleotide sequence ID" value="XM_019177926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRY1"/>
    <dbReference type="GeneID" id="30195062"/>
    <dbReference type="OrthoDB" id="2574774at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32220" checksum="475BA6A565A978D6" modified="2017-01-18" version="1">MSTTDTEYAVSETWKATDGKSPSIKVISSDNVVFHVPEYLLRAHSAVLRALLEDIPPPTLSSSDDAPTPFEDPSRIFELTDSTLESASTLTFFLSVISGKDLDIALEEITTEDYVLTFYYAMALAKKWDCALATQVLRLWLMQLAEKGKAHAHIKPLDIFLIAAKYDLPDVAARVIAVYKVDQSCLTRPSSGRWAFLPSNKGFETQHFERSAWQETPGAYLHALALTPVSVDLNVKCDRCRNQGRDYYGEAQCSLNSGEFKAGFIQVSSSKRAVQFIEHLQVKYTKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISC6</accession>
    <name>A0A1E3ISC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030105.1">
        <property type="nucleotide sequence ID" value="XM_019178066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISC6"/>
    <dbReference type="GeneID" id="30195211"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN91479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="42439" checksum="8C20195D7CFA1DAC" modified="2017-01-18" version="1">MAKWKPEPTGDDTAKYSLSAEFEPAHSGDVKAVLAVDDDLLVSASRDSSVAVWKLGKERFDLVALLEGHGAYVNSLAYVPPIAEDDNRYIASGGNSGVILVHNLTTLQTTSRACLIGHALNVCALSYSSKQQKLISGSWDMTARVWSREKTQCGEGEGQGYGEWKTDVVLEGHEQAVWDVAVVEGSTERQYLTSDRLVNLWDEGGQLLQRFKGSPEPVRSLAILPSNDIFVTACNDGLIRLWDFTGSVLQVLRGHTDYTYRVIVGTDSQLISCGEDHTARVWHEGEEKDILPHPCQTVWCVASLPNGDIATGGSDGVVRAWSRASTRIASEDIQKSYRERLPVIPDRSVSRAPSLTAAPEAAAPVTMTIDIDLRYLRHITNLNLMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISM9</accession>
    <name>A0A1E3ISM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_06027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029813.1">
        <property type="nucleotide sequence ID" value="XM_019178094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISM9"/>
    <dbReference type="GeneID" id="30195239"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="333"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODN90711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="695" mass="74910" checksum="6DFBBCC18DBDDFB1" modified="2017-01-18" version="1">MSATVSSTAAAVANTTVSAARASLKAKIAAEKKIMTARSLHMVYDDWIGIAILFGICWFFIIPRFIARVRAPTTPRGHSLTRGWFLRKGTDESIDGTASETSSQTVTDVGATTTPPTHVKPLISYIPGGSTLFFYRPFQNLRWGFKSFAKMYDVYLLALYLLLVCFTIAWRSPLKLKDATTGYVADYKRSGYVAIAQFPLCIALGVRNNIFGYITGKAYDRLKIYHKVTGRIMFAATIWHVASYLNRWVVNGVFYRNSAKHYAKFGWLAFGAFLIIMFTSLPWVRNRCYGIFKAAHVIGFILMLVGLGFHVDREVSVPITVSSGVVYGVSMICSLTKTRFASAEIVAHPGSDVVTVTIPALKSGWRAGQHVRLRVPATGGVHFLEGHPFTIASAADTEGAVLMIKNTGDWTRKLYKLAAKSAGDAEAPGAPLKTTVIVEGPYGGMGNTLPESFSSVLAVAGGSGITHSLGLASELIMAAPSGAVRPRTVDLVWMVRTTAMARPLLPTIHGLVNEARGWEVKCLASKEQTVQPTALRVHIHVTQAANAADIDVMNFHSVPALENEKVSVDAPLAPSADAAEGNVTPPALSPADEVDPEKLAYMTNHPGSNSQLASTVLSGVVIHPGRPQVGTFVHGIVDETISRHAETGAKANGVCVAMCGPDELLVDILKAGWQVEQSKQKACGGLEVEEERFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU42</accession>
    <name>A0A1E3IU42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030268.1">
        <property type="nucleotide sequence ID" value="XM_019177884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU42"/>
    <dbReference type="GeneID" id="30195019"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN92134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16803" checksum="13751B9C586501CA" modified="2017-01-18" version="1">MAPTTTDEIVTHLFARPLPPLEPGTQIYDTSIISSISALDEHRFVKAALHLANDDINHCHLIAQDSEGDSDADLLHATLHRREGDYWNSKYWYSRVRKHPVIPDISKAKSFVDACEKVKPGKDTQLREQQWEELKKIVEWMRDNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU51</accession>
    <name>A0A1E3IU51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase (Ubiquinone) 1 beta subcomplex 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_05817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030278.1">
        <property type="nucleotide sequence ID" value="XM_019177894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU51"/>
    <dbReference type="GeneID" id="30195029"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN92144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7033" checksum="0356FF15D833552B" modified="2017-01-18" version="1">MPGPLYRDPWAKREAWRKSPIFSNRAMFKGMFPGLGTAIVAFTAYVIYDDFFAARSSHGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU57</accession>
    <name>A0A1E3IU57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030222.1">
        <property type="nucleotide sequence ID" value="XM_019177838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU57"/>
    <dbReference type="GeneID" id="30194972"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000077">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="472"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="858" mass="95750" checksum="58A95C41A358A7B4" modified="2017-01-18" version="1">MSTRSTSAGSGAAVPEGKARLLYCKSHVAIHPTAFKTDNISGYLGVVETQSSKPQPADEEAKAGQLSVAGEGLLVTWVPDEVLERMDEHDRDVYKKLGHKEEGDEEEDGFVFVSVPPPKGEKYAFSVPVTNIYSILVYPPSLSHWYGSATINLTGGISLPTLYFHDDESPLLASPKPSPQPDAAARPTPRARWGFPPILSLLESRAVLVRSRLLQGKRSMGAELWLVNPSKSDREVHEAGVPDEEPETVPTRKPPQTQQTNSPRKAEYPPKPDYPAVYPGFAGIENLTPKQSILTGLSSLTSLSRRKASQLLSHPLAQPVVPHLPPAFKSLVNVPGEWERNGRTQGANAQNGGRGGSDVASEFESARLYLAKWARVVAEEGERARREELAAQARIRPSSPTASTADVDEDLASSLGVFSLLPKSYAKRPVPSSTRHPQNPISLQDWVTFEVEGKDELFVRQQIFRRGFSTLPVDGQALREGWEVLLSIVPWHIGGADTSSDGLGKRCQERNEVRDGKRQVYEGLKRKWKADADEGRGDEGWKEEWHRIDVDCRRTDRNQPIYAVPSDLAKANAHEKEGSTQVHEYGDGNDEDEEGGMAPLNHHIASLRTILMTYHTYSPELGYVQGMSDLLSPIYVIFDGNEADSFWGLVGVMKMMESNFLRDQSGMKKQLSQLQQLIAVMDPELYVHLERTGSLNLFFTFRWILIIFKREFPFTTIPRLWENLFTGYYSNQFVIFVALAVLQSHREVIIRYLVEFDEVLKYANDLSGTIDLESTLAQAEVLFISFQAMVEDIDKSTAEEPQQGELRQRITGKGKGKEAEPQEEPEVLREEQQKVQAKKLISSDLRELLVGWTPGQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IVZ4</accession>
    <name>A0A1E3IVZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030417.1">
        <property type="nucleotide sequence ID" value="XM_019177666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IVZ4"/>
    <dbReference type="GeneID" id="30194798"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="402" mass="44697" checksum="7C8C73C152C0F38D" modified="2017-01-18" version="1">MSPLQAYHAFLLSNLESVQTIESSLSNITWLLPGRFQDAELASEGLYSVVSLIERYHDTILTKHLSSSLSLPPHPFAQPRSPTSHISGSPLAPADPTRIHPSLPPASDHARYTRYWTDRSRLYRRASRALTTVGYLELLVEMVARKKLGERRRWKVVLGLEALKTFLRLILLFKTRRPVLSPSTPQREVDYASLPPEVLNPTASPNSETSKQSSQPLTPSLPAFSPLRAHLLPMVGNLPEEYLEHPLDLIPTLKGSEYVAEIIAASVGLIRVLLLLRASRKSPSSFHPYSLPTLSRSLPPYLIPLLLLFIYRHLRSGSSSSALGSPLLLSHNATQDRRLAMQAFLTGPLWVGWTRPKIVKVAQGLERIPLVGLVGELVEGYLPLVDDYFYCEFGLLGSGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW51</accession>
    <name>A0A1E3IW51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030270.1">
        <property type="nucleotide sequence ID" value="XM_019177886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW51"/>
    <dbReference type="GeneID" id="30195021"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF107">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 92A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN92136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58007" checksum="4728A323D0C68556" modified="2017-01-18" version="1">MPSGNKHLVTVPVAMWGHIRPLLHLILNLLRMHPKLRVTLLLTPSVTSRVTQEMENTQGFDTRDMDRLQLVNCVQQALRAEGQTLAELAEAASFTTALPVVMSELFNGNAEVNGNVNKFEGVKPTVIVYDLCQHMVVSIVKQVAMFLGVSLPPLLMFLPCNAAAAFHMFASERNNGVWATVIRDTQEEIAKGATPVEVFAKHSYRNTGKAVPLPGLPTKFDYEWWPHLATCPLQPEMTMAILPSYHALQDSATKGVILSSAAELEPVAVEALEAEIGKKVYMAGPQFPGVMWEGHSTIQTHSADDERVVRFLDEMKIKHGSRSVCYLSFGSAFFPLLRPELVRYIVHTLRQTDTPFVFAYASGIGPVPEDLLRECEEVENGCLVKFAPQWAVLNHEATIFFITHCGSNSTGEAILAEVPIVSIPFFGDQAQYAALLTEVLHVGINLKQTKTFQHPDLYNTLYDGTVVVGTEAAVKKEMVEVWGRMKGKEGEEMRIRMKKVRETMSRSRGMGLSLLSMKELGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWG4</accession>
    <name>A0A1E3IWG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030175.1">
        <property type="nucleotide sequence ID" value="XM_019177791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWG4"/>
    <dbReference type="GeneID" id="30194925"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="49226" checksum="A589B0BF8A1303A1" modified="2017-01-18" version="1">MARPAKPQFFLAHAPSPTPSPTAGHHPHHARTSNHPRLGPGVMLGDHSRAGESTESLKRVRTLSSDFDFQGTHGSAPHLRFDASPAESVLLSQAECLDAVMEIHKILYLGQDGTEDRAWDDKVQQVQNLLSECFEGDCVYDTPLSRVSSRSSLLSHFALLHLCSTLYLPSLTPTSLVLHARNATSALMKRAAGIERVDKNAKPSDLAKSDFGLEEVWLGLPEPECPTEGEGWWRLWEVRADCREIGEMECYDGYHLAMVDQIISLQFLPSLVRRMPGSYTSTPLLETPSPIATPNSLPSLPSPSFTSRLATTVLNELEVVLHWELPVTTFVELNEVGKATYIRDKVDLRDAVEAVVPFAKRLGWLTRCFSGMMSSFVGDIILGSAGPASLTGDRAEAAVGMAYKTKEEGFGCVAALNGEAAREGTDNTLGLENVGSAPATAHAPDVDPEAAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXN5</accession>
    <name>A0A1E3IXN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030485.1">
        <property type="nucleotide sequence ID" value="XM_019177332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXN5"/>
    <dbReference type="GeneID" id="30194454"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="101" mass="10702" checksum="A2FE8648D329493C" modified="2017-01-18" version="1">MATFLPTPSSSSIPSSLPSSSDGATATLASTDIPSPITKRPIYFLRISISILFLSISQGINILECFPPGAAHSQWVFEQAARSAEVAWKGRPKNIDIVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXY3</accession>
    <name>A0A1E3IXY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05342</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030582.1">
        <property type="nucleotide sequence ID" value="XM_019177429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXY3"/>
    <dbReference type="GeneID" id="30194555"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN93477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="427" mass="46274" checksum="9E073DA0EE6DE6B8" modified="2017-01-18" version="1">MSRLSPLRNIARSLRQTAFPRALPAFQARNYGKGLQTDMMTGELISRHGEIDPSALKIDKTTSAKTQLPHDKLVFGRTFTDHMLVIPWSSATGWDVPHIKPYGDLSLDPSSTVFHYAFTLFEGMKAYRQEDGTVRLFRPDMNMARMNRSASRIALPNFDGEALTELIKKLVVLDSEWIPKEKGYSLYIRPTMIGTQNALGVGPSSDALLFVICSPVGPYYASGFKPVQLLATTKFVRAAPGGTGGFKLGANYAPGVVPQSEAAKEGYSQNLWLLGPEHALTEVGTMNLFVAFKQADGTVELVTPPLDDVILAGVTRDSALQLTRDHASGKAKIPGLPEKLVVSERKVIMKDLVDAEANGTLFEVFGTGTAAVVSAVDKIGYEGRDIQIPVGPDGLGPIAKGVLHQMTAIQTGEVEHPWSVIANDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J022</accession>
    <name>A0A1E3J022_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030693.1">
        <property type="nucleotide sequence ID" value="XM_019177112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J022"/>
    <dbReference type="GeneID" id="30194226"/>
    <dbReference type="OrthoDB" id="683469at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF187">
        <property type="entry name" value="MUTATOR TRANSPOSASE MUDRA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="749" mass="83865" checksum="7791DD04BF7BEC9F" modified="2017-01-18" version="1">MDDASLDGPASLERALDIAAWAEDDEQLQDTLMRSSPIQPVVEEDEDEEDEGTPSPADFRKFQGNGTEEELSSELRSGMEFDNADSAKVAIIAHSLAQSGASAKGESNAERIRYECGSKVDNGGASAACGYHVTITYRKNVNKWVVANKKRSKQNLVHTCTPLAGERLSHSCQIFVEAMLRQHCTVTRTSPAKDLQKILKDKLNCEVPLQAIYSAKLAITDGDVDRQAAAFRQLSAWVERFVALQEGNVAECDTRMGASFFAPRLSQLAWPHLRPLVSVDGAHSKSCHDYVLFLAVASDANKQSVTLAWGHAKTEKRESWEWFLSRLSDCYPGLDSKGTVIMSDRGKGLVPAISNVLPLAIPSHCAVHLIRNVRNRKHIGSTKEAVNIFKKMIWAETPEEFQRHRAELSGPARNYVDTFDTAQYACHAFPTTRFGLVSSNTVEQLNGWLLVARGGDIISLFSTIYDHLRASFRDRHNLLVVKPRLVERDIIQDVYRKVRGEKSKAKDYRALVTAHAGRGGADEEEDGADEEEDDEHMFLFSHVHRNGMDGIAKQRIVRLELPVGTGEFRQWALPCRHVWAVLLNDYVLKRFEKRLNPLRYIPHCHSSLAFRKTYSFQFDPLPTDNFEETQFNLPDKIAGLGRRSKKRGQSGVAPTQNSQLRVEGGMSQPGVVKKRGRPKTSKKRKQPDGTLAPLGKDELLPAGKRCYQCGLCEGGARHKARSKKCKYFGRAVGEELEVPRDVTNWRDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J028</accession>
    <name>A0A1E3J028_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030725.1">
        <property type="nucleotide sequence ID" value="XM_019177144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J028"/>
    <dbReference type="GeneID" id="30194258"/>
    <dbReference type="OrthoDB" id="2573365at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="2">
        <location>
            <begin position="407"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="60439" checksum="CC0861AE20270A3F" modified="2017-01-18" version="1">MDDPLQSLSKGVFVLPFSPQDEATEVPPDQSEPVVQELFDEIYASTLNSIEEAYSVYEEQRTQQQISNVLSWLERCNEPQTIQLIRPIHRLPVAVLQNASESLPSHFSQLDIYHHTVQGARSFTDLASAIRSIAIGFIGDATVSGKRTGRSGIDELELWWKSKTERPLLIHVRDAQMIPSSVLSELIFTLTLHPAIPLRVLLSVPSSAVFLSTWGHIEPSAVDMCILQAGRIKKKAGGVDAIIRAFERAPLKISDNLADELLTQEDQLDGGPAAALKTLKWALLDFYVDGPLAVIIQNADTAEKQRKILQLFKIIRANPAKPDVPESVKYLLNLTLHDNLLSVHDPSPRLSFLHALSNPEQFVSLFDAYNGQSLSTDARDIAPGPSERAEKQSAERSNKRPRLEAPRKDESVRQVDLAEELKRLKVLFGIWKEAGKSVNLWDWLEEFRDVMDESNAEGKENAGGRGEGEGKESELEISETHAEHGVGGANGNSNGDRIGRKQEAEEEERLHAIFVRFVEEARMLGLIRAKGKKADEVLKSVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J088</accession>
    <name>A0A1E3J088_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030831.1">
        <property type="nucleotide sequence ID" value="XM_019177250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J088"/>
    <dbReference type="GeneID" id="30194369"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130137" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="219"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="446" mass="46182" checksum="C1CAFA5B18C61D04" modified="2017-01-18" version="1">MVAINLLPLFLVLPTLALASHNSPLDARSPHRRHNHARAASFAVGHASDSVMKRAASGSIEEKMARKRDGKDMANVAKRGADGAKCRKRGESYTPTGVSSTLSASSTVVSSTEVISSAASTTDVSSTSASSETVETSASTQASSTDAESSSIVNQQVWVDDATSTSSSVAAAPSTTSAAAASTSSASSSTGSSVVSYANLTPNGNKAGLSAGDALPWVKDHIGWWYDWSANPSGDSGSAVAIPCIWGSGSADSSDASRLSVFSAITSTPSYIIGFEEPDCDAGSGSSGFDIATGIALWDSLVAPHGEAGSVLVGPSMCKQAAESGWLSPFLSAVTRKPDIMNIHVNKNSAAGINTDIDHYWNTYGLPIWVTEFACVDDSSSFIPCTDQSEINTFIQTAVDIFENDYRIAGYAYSNGDGLSDAWAMVKNGALSESGQTYLAAISKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0I3</accession>
    <name>A0A1E3J0I3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030853.1">
        <property type="nucleotide sequence ID" value="XM_019177272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0I3"/>
    <dbReference type="GeneID" id="30194392"/>
    <dbReference type="OrthoDB" id="2597011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="624" mass="68536" checksum="5653F7775A58A4AC" modified="2017-01-18" version="1">MPFSSTAPSTGISSTSPLATSTSSTLPLLLTRPLRTEHRWQPKKNNMSVSLHSLADAALADASERPSSHSRSRSSFALPPIADLLNPVTDSQSSAARSRPQTPTRQPLVKGWSPTTPSSQPRPSQVSAEQPAQAFTSQVPGEQAQVSFEYNVRRYKRGGSSRPSQPPAQTTRRHTAPVIPTTATCRTDLSCNDPAQNHGPSSAKGKEYPLQGVQLDKHYPELSIHGWHEDARRLLQPPLAFSPSYVQRDPSENAVRRSVSQGSYPFTPVESGVQVRVQHPRPCWPEPLPQLPCTYVPYHPYQQMPHHVPIIAEPQPRPRQRSYRFISQNEELANAARAGPLQASASQSCFGIERPAKRQEERKKVSASAPVSPRSKERPPLATAASSNPMTPVSSHEQRSNRWTRHASPRSSYPVRPVSPAQSTLSNASTILPIDGEPGLDMSSTTSSSGSEPFDGTDMDHDESDSDDDSDARDMGGKRKRTLQKMTSPTNSTLSTPAKRLLDSSQQGSTPTSSTYQDCSPESLAKRQRTSRTGRLYDGAIGPDGKPVKRSQGRNKEKRREQNAVAQKKFRWKKKQLTEKMATDLESANATIKDLEQRLEDSQGLVNKLQSELYVSQKTAEGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Z8</accession>
    <name>A0A1E3J1Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031137.1">
        <property type="nucleotide sequence ID" value="XM_019177105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Z8"/>
    <dbReference type="GeneID" id="30194219"/>
    <dbReference type="OrthoDB" id="2574383at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="242" mass="26728" checksum="38C3B6E8C0C76DE0" modified="2017-01-18" version="1">MPSENRAPKSSNSSKPTKSKNDIAASAHKAKDAMSQNTTQAYGALMGCFGGEKKFNEVIQKYNPAFFDYAENVVLKSAPIEYKASKLFVTLGVIGMFQFAIPIVHWPLEVIAKFLQFSFLYTCGAKELRKGFSTSSSVNLVKSLLITFVVVVSLQTIPSLLFDIHYHFGALWHFCLPVLLLSLPSPQENDRTVAIFLCDVFLSSFLNTMTATMTGMLPEIDLQDDAQRVPALFAFSAFAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J246</accession>
    <name>A0A1E3J246_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-40S ribosomal protein S27b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030727.1">
        <property type="nucleotide sequence ID" value="XM_019177146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J246"/>
    <dbReference type="GeneID" id="30194260"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN94196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="140" mass="15951" checksum="C64780203DA56534" modified="2017-01-18" version="1">MEWQSFSPKTNEFAGQPHLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALANKYNCDKQICRKCYARLPPRATNCRKRKCGHSSQLRPKKTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2X3</accession>
    <name>A0A1E3J2X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031190.1">
        <property type="nucleotide sequence ID" value="XM_019176715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2X3"/>
    <dbReference type="GeneID" id="30193811"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130095" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="146"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="867"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="928" mass="101225" checksum="4B7E8FCAC2B97E95" modified="2017-01-18" version="1">MRLTLLALSLPLALAQASSNSNTQSQSASQTASTSSNATSSASTNSTSTQASTTQTTLTTTLTTFPTTTSLSENPAPSTYTLTFTLSSSSDANSTSIDDQLASLNTSISNGTYTDDIAPDNGTLWHEGDGWIPFHIVIDPAYGIAGAFLIITGIPVATLGGKNRWSALAISSGYALMLFTLVLILRFGVEPDINTLNPNPPSKTTRGLYLLATLVSALIGGGAGIFFFTFAKHAISAGGGFTFAWFLLACKEGGLVPKTLGRWGLIGGMTVAWFVAGLPKLTNEWMMLVSTGFIGATAFVLGVDCYTRAGLKEFYIYNLGFHDLFPKLNGAKFPLTQTMMIELGIIGAFVIVGAAIQFRVLNILSKKLKHIQEEEDAKIEAVEVARAAERFKNVGVELEEWEGKYGVNGTGGEVVEDKEKQYAAYEAGYRERQASAQAADRSSVLLPQLGWDDSLDSRPSEETSFTHTRQASSTLSLLNHDSLSRPRRPSSSLSLLRQPSAPGAKDKKGLYESVNPDTPTPTGSIFGNLGMEELKLDLDTTPRSDPSSRPAPGMSTDDDLEEKIRLLDDIKKARESLRGSLDMLRSGTPGSSSLGENDRERRYSSASGKLLDDPRGRTTSVGSMPLSGRSTPLEPVMTQPLNDAVRPAKEAPTSEWDAYLASRQIVTPTPTSPHSSSHSPYPTQPTSATASYFPSRERPRESEYIDMPMSVARGIEERRKKTKSMLDQRVSDFGPRDGGAGGATYPQEQRHGRSEGHGRESYYGHGHHGSFSSERLLQQRFSSSASYYQPQPSSQPPPPDQGQGPQPERRSRTMSYDQLALRHRNRLSQLQMPVTHKLREGDEHEEKKKIEEEKKKWEIRQKEERIRAERAGRAREEGRESMAGRGEGRRKEEMEDWRRSVVLDAAAPALGPGPGGKKVEKRQSRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J332</accession>
    <name>A0A1E3J332_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031239.1">
        <property type="nucleotide sequence ID" value="XM_019176764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J332"/>
    <dbReference type="GeneID" id="30193861"/>
    <dbReference type="OrthoDB" id="2561583at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="894" mass="98332" checksum="FF871B4B623E8893" modified="2017-01-18" version="1">MSPGSPEAQPAQEAQAEHRGLKACHACRIAKVKCLGGGPALKCARCASAAIECRFSESRRGRVKGSRNRKTLERLAEQAHQRSQLYPKPNPSKPPNTPSGRAISSPPNRPQSSQSDGTSFGPFSRPQSSSRSSNATQPSSSFDRQNLRVLERSFPTGSERVPDSSQIDAKEAGGQNDLHNPLLFLAECARKGWDSTSPWESPLVMPVPVGKLPAEDAKNLEGWRLRHFEEVVEDQRSYFQHGLHGSKRDVGEGLDPVSWRIIVDKQVEPLFDAYFLYCHKHWPMLDRNLHTPAFVRNRSVFLFTVILALGATSLATLPKSSTRERTTATKLFAHVEKLQLVICATAAKSIEIVQAELLSQMWALRTPRLVDDQRAMRLGMALRMAGQIGLQHPFRHSGAVPLDAFAKNDLMLRVSLILTESRWESIADRKEVINVGFDLTDSERSILHRVHPLDPEAIIASDYALYGFEVESKVRISSNPSDPFLLDTSLDAELSFIHTYLASWESHWVEPQTDPLERWSFQYAALRSLLVGLLRLAKARGNRPGPWTSNFRKDLYGVSTRILEGALSHERALHMLRPTSVLVFVSTIVIQLTDREARERDLILRVGLRLAGEAGREEMKTFATHNGFQILNMLCLSREEAGQRRAARILSFSDRVDGERQGSNQPKHSHDAHQVSTSPARSHQFSSSLSSTSSSPLDRSRQNFAQQPSDYYLPLPVTSQDLYNVEPQSPNQEPGHMNAGNSGLDQLLAFSLDDVDFPYISDNAMAAASAALHNGETLGQRGFSHSAYVSDPVSFTNGVSGRGNESQIAGGEPTWSDLLAAIVTGRDGGEGGMSDMSGLCSSEDRGIPTSEGVGGMNWAAYHEPAGQGTNTASGPEGDRMTTELYFQLASALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J397</accession>
    <name>A0A1E3J397_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031304.1">
        <property type="nucleotide sequence ID" value="XM_019176829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J397"/>
    <dbReference type="GeneID" id="30193933"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="424" mass="45919" checksum="D9C2C1C34BC8CF72" modified="2017-01-18" version="1">MCKPRWGQSRRCINIIINNGTVSEARIDDMSQRIMAAYFLLGQDEDYPEISFDSFRLSGSNMSHVDVRGDHHKLIHHIGASSTILLKNENNTLPLSTPRSVALIGSDLAPPTDGANGFTDRGGIGGHTAMGWGSNSGSAEFPYLVDPLLYAISRGAEVAIVGVHAHSGEEYITVDGNVGDRNSLTLWANGDNLVQAVASTNNNTIVVVHSPGPIIIESWIDHPNVTAVLWAGLPGQESGNGLVDVLWGDYNPSARLPYTIAKDRADYSADIVYTNSEYPVQPQIDYTEGLNIDYRHFLSEGIEPRFAFGYGLSYTSFELSNLSVGAIEGAGDLEKRDVLLNPPQVDETPAEETVEIGKFVFKSLHKPRWSLNSVYPESAGEPPKVLRDFARINLDPEPPKLSLGTSPNTTSPSGMLRAGQVCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4F5</accession>
    <name>A0A1E3J4F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031425.1">
        <property type="nucleotide sequence ID" value="XM_019176497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4F5"/>
    <dbReference type="GeneID" id="30193591"/>
    <dbReference type="OrthoDB" id="2591431at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130122" evidence="3">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="553" mass="57206" checksum="760E473EA03A8792" modified="2017-01-18" version="1">MPRLPLLLTTATLALLPGLSAFSFSFSHGPASCDQAVVTWSGGQSPYSLTIIPAYDYPTTVSIPDSAYDDASGTGSYNWTANYPSGTSFVAMMSDDSGTGTGGVSELFNISSASSESSCDMRSEETDFLFYLNETSLTQCQGVEVYWDDSAVSPVSIIGAIPGGQVFQLVSSDEKTTSMVWSTNVQAGTDVIFAAFDSGTHLQGGSSDILTIQGSGDNSCIDDASPSSTPAASTATQTGASGGTKTNAGGVKTVTAVTTQTASAASGAAGLSTGAIVGIVMSAVVVVGAIQIALLWFCCRRQIRALIYHRKEMRGTEIKPSGGVDLGLASRASFTSGRENDAGMGELAGTERRGSRYSTVRSHGAGEDFEAASSISPFWDGAAAIPPSGSVMSLNALGNGRPPTIGSLGFDSEGESLRPPRGAFGRDRNDSLSSLTLTIPETIDESGQPSPAYDAAHPSPALSNSSNSPLVPSSAALGGRGNMSKAQMAASLSAQNADREGERDVYFGARVPPPEAPSGGFRRHVDAGAVEDLPPMYRPEWENSPRNSQHERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4G1</accession>
    <name>A0A1E3J4G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031392.1">
        <property type="nucleotide sequence ID" value="XM_019176464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4G1"/>
    <dbReference type="GeneID" id="30193558"/>
    <dbReference type="OrthoDB" id="2574139at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="517" mass="55361" checksum="CDC256CFDDDA10CE" modified="2017-01-18" version="1">MPPRDLPEPLDAVPRLPLDTSLPSALAHLVHHLVDPLARHYPQHTTQYLLEQLKRDLFRHFQPTWDEAHPQVGSGTRSLICTRHLGLPMPMRGAGTRSGVEERVWRKAIAEEGGRSGDVNMGEEWEVWCDPGQVVWRWGPWEWEDPEFEPSKIVRESLQVIWQSAADGDKLSPTTPAKTAQGTPSRPSYAVPIRAPTLLAIPPTPSRGQGQNEAIAVQESLLPAFSTLGLGRPSDGGQNRVSSGWSSSEEASSRSTSMTYSEEQPASPEHRSASRTSHRGSESQSSISSSVSDSNSGHTQLLTPATRPSTADPFTVSIVPLRESFRQESVDVFGDRESSEKLKTTPISQSRGRASPNALCESNVQPATPTTENTITPRVPTPTVTPYDGGNVTVLGGGIKLGGGAGSHSRSSSVQSSHRTPIDRTRSPSVSFASRALSSATGPNGEPRKQRTRRRIMPTYLGHLGQPGVGGPVMGAFNGVVSPGTSGGMGYGFGAHVGVGVSPPQVGIRGPMPRMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5E1</accession>
    <name>A0A1E3J5E1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DIL and ankyrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031306.1">
        <property type="nucleotide sequence ID" value="XM_019176831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5E1"/>
    <dbReference type="GeneID" id="30193935"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="447"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132157" checksum="2526A2F4BA17B072" modified="2017-01-18" version="1">MTTTTPQTPQTPTLSSPFTPTRRRTSQQFSPISTPRMGSVGDMDTPHVLQRAVMEGQDVPESPIIDRGFAMMLSPGYRVGESSTGGIGGAVPEPRFLSDPSPQSIFPLLDEDEHNATQETDLRKALILRHAIHWGVERGDVDLVNWICSLDGRWRGVLDKEVETLEDSENWGIVGMAVMCTCGRQEKEEIVRAVVQRWGVSVGPRGGRDRNGWTPLHLAVLVSTPPLVSFLLSHGASPHDTNSRGLTPLDLVVGIPDREAITLFLEHAISVPHPSTPLPSSSFVPPSSTALTSLPPTRQKMLGRRRRKASRYLEKMEAQGRRERVEAERERWVRDRVRVVDVRPELVLPRKEVKRINGLEVDLDLELDAQDQADDEEQEEINHLEFNSNMLVFSLVNLPEIFDILISDYTPVSQPLAKRTLPANVLFYYARFAWYMCDEGWLEELIEGAVERVEEGVYDNIEDLAFLAFWAYNSCVLLHHLQSDEKLRVACEDLGLLTMVEELVNAIHVFVIRIAERRIDSVLDSTILDYETLDDFADVRFEGEWSLFRSFVPKKKREMPKASSIFSAAGTSPGGLSTSSGSRQSIDLSVSPGVASALRTPTRPQSMGDLRLSSSGRSSSHESGTSSTFSTPGGNTPAPEVDSGPGKITEILTGVLLVLQLYEVNPALIVQAFSQIYFWIACELFNRILTRKKYLCRSKALQIRMNLTALDDWIRSNGLPAKIATQHLAPVSQLLQWLQCLSQIKEFDTLIGTMQGMKAINPLHMRRAVRDYRYEVNEGRMADDCSQYLVQLQRDWERRRLQQAGADAERRKSHSSEWSEESWGSEQIGASGWSGGMEEPTSVDALFDGSIVLAEFTPHTAPESIGELLDSRYMLPFLLPEEEIYLIAAPPEDAAYQSLHLPSSPFVTDTPTGRPFSRSSFSSSRPLGYRIPSVGKIRELTPDFFKWMKEREVEMKLSREALKIEKRAVPALVHPLGPSHRGAMTINTTMRPPDDKTNLSPTPTRTINKKRSGNFSAVSPSPATATPPAVKEADISTTLSMLYPTPTKPGANLPSPGLRSTASLNELREKKIVGNAFNDIVEEEGDEVHGHVRSESFKMRAMAREGSGDSLSSNDSQPTGPAFLTSPSSIESGGGSRWWRLGKGEQDSETERRRRDASEDTIAPGDGWVPGDVKTPDAKTPLSAKRFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5H6</accession>
    <name>A0A1E3J5H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031560.1">
        <property type="nucleotide sequence ID" value="XM_019176632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5H6"/>
    <dbReference type="GeneID" id="30193727"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="85749" checksum="BEF7F1485A141297" modified="2017-01-18" version="1">MSAPAWENQAPRVHPQPHPFPPPPHPIYHPPSQHPTAQWHPAPATRKMHPPPDPSCTPGAPIPLPLPHPSHDFPTLNTVDAFPRKGEPEDDLAGIEALDPALYDTPPATAMEVVPQHARGRSQSVASMKEGEEGSTALTFFPNPTQPPIQLKGARKSGLLPAPAGCKLEVNQLLILRPPQASASQSFDGQTSKWEMYTCRVCSKTYDGKNARSVARRHLQDKHGVPLSLQARRSRWDYAEPKEKNTPELREITLKSKRDWAVKHRQQSKIEKTHAEFLEQFGPRGLSATHGIILIAPRFRGPSGALEAGDSPFIDGINGSIVIPEEILTAVSILRANEKRLKSESAPTMPLRASTPPDRLMSALTVSPKSPQRFPQPPQSTHHEIYQHQLDHLRRQHATRPFGFADVPMADRHPGGYGPPTRGVQGVMVGQGQMSMPVYQRAAGEGVSGQSVEAVAFASAHPETRAPPQQAPQPQVLEPAPEIVSDQDESSRGASKDSMDIEAEVAAESLLNLSTPIRAPEDEDPPTADPATRPAPPAWKLLDAPSIGPATKPRPARSKSSLQPFRDPRPEVTRSLSFEQTPGMDDDPFGFGETPDRPTSSATGSSRTRAVTSSRASRKNMPSPSPLSASTRKRKAPPSSPFAPPSKTQGQAEAISRPALRPLSTSFSNSNRGFTTLTATPIRSAISTTTPHLRAPFSHTKNWLLSSPSKQGDDDGAASLGLVPTHLAPATPGMMRGIIGVETPDHWGVEVGGKEGSVAGAGAGAGAGAGAGVKGKENGGETGLGTGKVKRKKVVLDTPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5S7</accession>
    <name>A0A1E3J5S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031281.1">
        <property type="nucleotide sequence ID" value="XM_019176806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5S7"/>
    <dbReference type="GeneID" id="30193907"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="104"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="717" mass="78388" checksum="E0015742E345A460" modified="2017-01-18" version="1">MPASPAPSSPLFSLDHPSPGSRTGSDDDEMLDTVDLNADPAPEDDPWRTVPLAAATPSVAGASSRDSGASFRTDTTQRLSRAVSTPATEFTPTTEEEGKDIDVAGIEEGETPMVLGVAVIGPTVEFAHPASLQDALANDEDLSRLLPFLALPDGAHLSEEDYSFFHCTYSPSDSRVHTNVPSSQTLFGISCNRQLASTELLKRPSDVTRSMVQKAVIVVASKPVFGPIRDRLGVVTRAYFAQRDFTHTQILEDFYHSLETSLQGKSGEEAIYMGTSLRELVHKFRHRTLILLKLLMLQKRIMLFGYPVDKLCTYQYSLVSLIPGLLMDLYESGRPELEKEMKKARPTSLRTSDRASLLRFMGLPLRVFGNGAFFQPYMPLQEIDKLKCKSWLVGTTNQIVTQQKDCKYDLLVNIDNNTFEFTDPKLEKTVGLTPADRKWMDDVVQTVEESWNLPEGERPSFRGSDDDLRARFEEYILSALSSIKYADFLTKGKASDISIIAETAGAPGSEGNVIQDFSEQWIIAFKETDVYEKWNGMTDPVLFDIHEPKHPCEGKAGVVSDIGLRLAEGLHDLHLDQQLAPTREVLSSAFQAGSQSIFKAFDGVRSEVDRRMKEREEQARARGAASPGASGNSTPTAKPGTPTGQDLKSTIGGIGSGIGSFFGSKVASFRAPPKDESPKGLRPMSLVGSVSSSSPKAMARSGESVPSSISRPSSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6M7</accession>
    <name>A0A1E3J6M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031763.1">
        <property type="nucleotide sequence ID" value="XM_019176353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6M7"/>
    <dbReference type="GeneID" id="30193445"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN96517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="280" mass="31582" checksum="AD9CDC75E845C807" modified="2017-01-18" version="1">MLTPPQPPSSSVLNQQFRAITGASAAEATRYIKKYKSVENAVDAYYNDNDDEPFAVADPAQEKKLGAIWEKYKDESNPKLITIEGTLQLCEELGIDPENDSVLFCLAADLGSKVTGEWEKAPFVAGIQSYPGTIDTIPKLKNYLPTLRTKLNTDPVYFKKIYTHAFTLGKGSNEMTRSLALETAIPFWSLFFPPAFNSTPSALSHVPDNSPPQFTQPELDLWIEFVTQKNRAISKDTWSLLVDFARQIDKEFKEYDEMAAWPSMIDEFVEYAREKKGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6T5</accession>
    <name>A0A1E3J6T5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional activator SPT8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031816.1">
        <property type="nucleotide sequence ID" value="XM_019176406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6T5"/>
    <dbReference type="GeneID" id="30193499"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="132"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="500"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="685" mass="73071" checksum="3D6398121E7BDF4B" modified="2017-01-18" version="1">MRSDEEDDEEEFYDENEEDEVNADGEEEGEEEGSDDDGSEEDNAEDEDEDEDEDEEGEDEEEEEGGDEEEDGSEDEGQPMDVDAPAENGECPVSQPPQPARSATPPHLVRRSFLKPAFNLQYPPRSLSVEVVAGIPLPTPIHSLGSSNCMSYLLAGGQDGFIRAYDFWGTVNGTQTMTAQQRSVVGLGETVNKAGVARGWWTNEVEGIVGGTLAKRPEAVYSMACEGDALWTLAGTQSGPINLYTLRHSPGHLVHTLKGHTNVVSCMTLLPEEKSFISGSWDGTVKEWDLNTGQATRSYPSHKAQISSIALRPTGISSSPPSSPAPQKDEDGEETGNGLAANINLSVGPDFFQKKDGPSENENSLDKASEGKKLSGESGDVDMASATTPNSGAVDSLFGDEASESEQPPASILPTNEPPPSLPSPDKPKTLGLALPGQRPTITIPPQQPQAQSRGQNQVSQQIPPGPPSAPLFKPLLPTSAKQAAANHIPVLSPAGYKNYSDDVLLTSSMDGQLVLIDRRVPSYEGAGSGVGRLVAGEKTPPWCMSATWLSNGNQVLAGRRNGTVEVWDVRKGSNAANTNILRTLRTPAGSGPISSVVAFPDGQHIATSSTDNLRLWNAAELFQPEDSIKRSKGKTPFRIIAGHHGGTISSMIVDSTCRFLVTASGDRGWGGESTKAVLIHEIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6X8</accession>
    <name>A0A1E3J6X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">STE3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031681.1">
        <property type="nucleotide sequence ID" value="XM_019176271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6X8"/>
    <dbReference type="GeneID" id="30193362"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN96435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42538" checksum="7B1A21DE1C60EAC6" modified="2017-01-18" version="1">MRHPDYPVWNFLALVLVLLPAPWHWRAKNIATMALVLWLAICNLVGFVNTLVWANDYIDRSPIWCDISSRVSLLAAYAVPLCSLSLMRRLESVASTRRSVITVGSRTKRIWEEVILCVVCPVILAVLQYVVQGHRYDIIESIGCNNPTFMSAPGLIIRYVIPIVLSVSSLVFAALAVRWFLIRRLQFRAILAASDSNLSISRYIRLIALAVTDSTVVLVAVVYSSVSALTDDSSPMEPYTSWSSVHSDFGQVSQFPEELFASSWVTVVLIVYAPILYSILFFTFFGFGEEAIVEYLAFGERVVLWMEKIGLKQKSFEPAFGTRPLNLGSKVVPAVTASHAEGVVRDDVSEKCFQGLESRSDLAPLSHGSVGVGGITVKVERSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8Q5</accession>
    <name>A0A1E3J8Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031839.1">
        <property type="nucleotide sequence ID" value="XM_019175926.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193013"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="235"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="564"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN97237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146316" checksum="2BBCD9913161461B" modified="2017-01-18" version="1">MSRAPSTRYKISNPQPLPSDLRSAYSTDARPYPSFPTPLPRQSSQRDGTSSNVSITPSKDHGGAIIKEPSTSPARPARSRMRDMPQPGVPQRRNADTRTGPGLPIQTAQISARASPQSDGLDIPPLSPMTPSVQGHDQELSETTDVFANDRSQRSELRAQVSAAVQQSQQPFRAHKGTGSDQVRNAVGAFMSAGRSRDDAAPPARRPKHHERAKREVKEEQWEDDFRNGEASDIDLTLRQVRKDWPFVMESDFSASTLALSLLSGHPSSSLPEHPGISPFLRLHDSLSTALQSAVQSESKPFAASLPGHQNFLDILAKAQEQVRESKSDLKAARDGFAGKGKTELAIVRTREKTVRDMLKILDTIDHIKQVPDQLETLIGDKQFLRASLMLVRSLKTVSKPELLEIGALSDLRSYLTSQETTLSEILIEELHNHIYLKTFYSDSRWLPYQLGQRELPIIDPQEDESVLSRSPDPSATKSKKSDQLTSRFSRYLAQLDQKPSADPLLLYSDDLAPPISRSIDTSHGLKASTAHAFTKSGSHGSLSSLAGDAEGPPEMLSAIGSSNPEVESFSYIESLLEALAAMGRLGQALDVVTQRAPAETHGLVESTLDEVDDRSQRRDALDVALRTHSSANPDIFAMPMSSSQRTRASLEASKFDVSLEATGPPQHVALLNDLFWTLYSKLCAVLEGHRVLYEVSRWIASRRDFRNVTTQTSSSMSFNAPISEMWRPIQQEVKSILSNYLTDDQQGSTLNRHHILSVNEFMRDPRVSRDKGRQLFKFTESDARAVQSEIKSVDDSVQEALHSSVPGLVNPNTEQPVLFTVDNDDRSVSGRYRTLVPPNAFNVTTLFQPTLAFIQRTSQIVPQGFEDETGGIDTVLEDFVVKVFLPQLDEKVTAGFQQAVSGYDAYQVDRALLVDTPQPPTKSSARVMTLIHTLCVMLQTTPFHRENYSRLIIGVIVQYYQQCSTHFKDLASVPSTMDNPSDRPLTVPAIWAQREDVTVYLSELRFAMASSTPAALSSIYRKELSIELDLLGSKAPTESQLINSQRKLEALGDLLRSLRWFVKALVDLESVADETTLPEGDPLNVNLIANTRPSINDEEPRLPLTRAMAERYRAIIQTYEQLAEMILNTIRLEIRCRVMCNLGAFLQNSDFRLESEALEPDSDILDLNTNLVEAEELVRNAVSCDDHEFVFQALGPLVDHCFTGFASRRIKCVNGAGVRKIKRNITSLQQILRGIGTNSDNGTLSKALGYWGLYEQGPKKMLEGLKAHKGRPPFAFEEYNTMLKLQCTDDTDELNTHLIDLHALSMEIDGWDLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC49</accession>
    <name>A0A1E3JC49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCF-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032322.1">
        <property type="nucleotide sequence ID" value="XM_019175832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC49"/>
    <dbReference type="GeneID" id="30192918"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="496"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="79413" checksum="BD060EB1A65DF95F" modified="2017-01-18" version="1">MLSLKDIPSEVILEHLLPVLPLRDIASLSAVSHFFRNVSRDPAFWRLKSTSDFSFSPASHPPAPSPDWWRRVYLGLLNPRAYVWGTSTNGRLGGAENGQGVRGNGPHVYEPAEIAWDRTSQQVTGGDSLAADPSSKDESKVSGVVELQAAGWSFTARCSDGSVWVWGQMDGTGFAFRPFGWENKHAIIRSPTVVPLPCKAEAISTGRCHLLVLDADNLIWELRSWGRAYHHTAPALTAPVNHGSNSHPPHIVQLSAGWQHSAALSSKGTIHVWYPFTPAYRESLSADDDLNGPIKPPNNDGGDDDDDDERALRWGKVGPDVVHELPSIPDRPGLDEEDDKRSEYGGRDRGGHTSQELRALWSEYESTTSRNSQDDQRVVKLASGADFLLALKANGEVWHISLKQDQPLRWRYLPYFSSPSITHITAQFQSITSYATPTFTSDTSALCHTRLEDDVPVSENPDILLHRPDALPILQDKQIIQVASGDYHYAALTSKGEMYTWGKGNNGQLGLGDLGGKGEEVPPTKVEFDHDEDDDDDEGVFVFAITAAGWHTGALVLGNLDSTKSQRAKVNTSDKKAVKAAEHGPSTDVWRGPEIRHLPLPRGRAGFRGRIGYAGRGLFQGIRGGHAPAAGGGHGIAGQEESQAGGGEASSGQDSSGGAEETTGEGSQQVAGTSAGGVEGQESQQMSSNNHPLQQPSHRGLRGLPHFRVGLAGRPGNLARGGGENNNGVGFNPDGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCC8</accession>
    <name>A0A1E3JCC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032197.1">
        <property type="nucleotide sequence ID" value="XM_019175707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCC8"/>
    <dbReference type="GeneID" id="30192792"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001277">
        <property type="entry name" value="Elongation factor 1 alpha-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000107">
        <property type="entry name" value="Related to translation elongation factor HBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="453"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="886" mass="94855" checksum="2A4ECCBF7B7BBD40" modified="2017-01-18" version="1">MTTAEVHEANLSKAMAVAKNLLKDVKPPIPDGEIADSVWHYWFDGEKAAAWLRSDREKKGEAPPSYLQPTPRQNPRPRPRTTLPIPAITPSTGDIEPPLTALQRLSLSRRQSPAPASSGTSLPSQEDKPMSKLALLAQKRREAATNPATPSLPLRTPSRPSTPATPPSLQPAASSEAGEKKPLSKLAQKMAAARIAREEAAKAAAEAKAAHGEDQMDVDEPSVDVVPVDDAVLSLFSVKSLPDPSRVVPSPSCPSSFFSILTTTCHPHEKVNGHLPPEPVSVNLHAPLVTDLSRLVKQFESAFGESPDEIVLKKRQGRAGTGNMDAAVPLTLALYAAAKQKQAQAKSLSLPGKPRTQPPATHAKSKLAASQPNSPTVSSSKGSSKPGSTGGTPRVGAGKNGLVNDMEALGLSEEMTEAEKERERERYKEKVVISLKQEELIAKAKEAEEQSGKKNVSLIVVGHVDAGKSTLMGRVLYDIGELTEKEKIANERGSQKVGKSSFAFAWGLDALGDERDRGVTIDIATTHFTTPHRNFTLLDAPGHRDFIPAMISGAAQADVALLVVDGSPGEFEAGFERGGQTREHAWLVRSLGVREIIVGINKMDVVNWSQDRYDEIVESLKPFLLSAGFNATKTTFLPLAAMKGINIVGNSLPALKEWYSGPALIDALDTVEVPARPYEIPLRIPVSNVFKGQTAVASGVAVSGRLCSGVIQVGDRVRAVPGDEVANVRTIEVDEDSAPYAVAGQNVTLYLSNIDPVHLSIGTVLCPTSLPVPLITRFSAQILVFDLQSPIIAGTPVELFHHSMNLPATISRLISILDKGKVVKEKPRVLQKSMTAMVEVTLRANSSGRVPSIPLETAADNKEMGRVLVRRNGETVAAGMVMELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JDX6</accession>
    <name>A0A1E3JDX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032168.1">
        <property type="nucleotide sequence ID" value="XM_019175678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JDX6"/>
    <dbReference type="GeneID" id="30192763"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="791" mass="84669" checksum="A3C888538067DB3B" modified="2017-01-18" version="1">MNNPYTPRGYDLPAHHQAAYPPEPPHSPFGYPALSQPQSFASHYSPLHPDQHPPYRRQTLPQSSPDTYSSAPPPAAGDRWNWDQPRTVPVPDSYSSYPLGPPIVHQRSPLPHHHASASYDHPPGPSGDMAGDLDHDSYQYNDLLPPHHQIRPQGYTKSSEEEEPPQQHDKAAVGKKKKGSKKTEGKQPTFLTKLYSLLGDEATSHIIRWDESGENIIIENPEELADKILPVVYRQSRFASFSRQLNIYGFNRKLSLRNVERGICDPDASTWSHTSLTRDSSPQEILQFKRRVPPRPSQSAKRSLLAQIGPTPAASGTGYHPILPGSNYNSSYANMENYPAFPGSGDDGASPTSSESMSGGGEAKEWRSPPDAYQINLLPDVAEEPPSAIYPSKEYLGFATQAGYGSIPRAYDGWKSGHAQGLGEDVVGSGVNFDYGTPERDLFYQGIPQHLSDSPKRVGIDIPRVHPSLPLPRQPLQAHYPSHSLSSAPADKSPTSLVPQSAPANSGGFSFPIKVQQQHVRTRSVQGEPPSAMLFSPMADGTWGDVPEPAQQQMQGQMNPPPSAPTAGQFDPLDPAAWVRRGMVDISAAAGSGTPVPFDSGTSSRMGSSPASLPNNIGGFAPRSIGHQHFASGGSIPGMGVLGGQSLGALSENSPSTVSPRAWKSMTGGAFSLPSASPLQSQLNLPPVTSNVTGPTNESPRPPSAITPAQQARQERRASIPSSPYISQSPRQRPMLLPGAGSWTGASLSPLRTIGSERGRRGSGVAVPESVESMSQGSVSGDEASSSGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEK0</accession>
    <name>A0A1E3JEK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032193.1">
        <property type="nucleotide sequence ID" value="XM_019175703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEK0"/>
    <dbReference type="GeneID" id="30192788"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130295" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="9">
        <location>
            <begin position="664"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="499"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN98331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="742" mass="82509" checksum="E79758C7E4252674" modified="2017-01-18" version="1">MAPLLSNGVRIVLALSAISLIPSFALAASRIQVNGLNFTLSGPSVSYQFHVNDDGDLIHDYFGAFAADPIRDLTEPGNGWRSPLAQHRREFPDQGRGDFRLPAFHIRHDSGSTVSQFVYGGHVIVEGKPALDGLPATWGNASDVSTLQVYLVDQKSSLTATLSYSIFPDIGAITRSFKLKNEGEANVTLERAMSWSLDLPPDDWEMVQLSGDWASEGRAMRRPVYTGIQGFQSSAGYSSHFHNPFLALVHPDTTETTGSAYGFNLIYTGSHTTEVEKFTPGFTRVLMGLNPLHLSWVLSPEETFTTPECVAVYSEEGLGGMSRAFHRLYREHLIRSKWVDQTRPVLINSWEAFGFDFTETDLEGLAETAKDLGVELFVLDDGWFGNTYPRTSDEQGLGDWQYNTERFPQGLEHLVNNITSLTTARGEAMKFGIWVEPEMVNPRSSLYDAHPDWVLSSSSYNRTETRNQLVLDVGRPEVQEYIINFMTDLLSNASISYVKWDNNRGMHELPQPSSAHSYILGLYHVIDTLTSRFPDILWEGCASGGGRFDPGLMYYWPQTWTSDDTDAYQRLFIQFGTSIPYPPSTQGAHVSAVPNGQLERTTPLEFRAHVAMMGGSFGFELDLGNMTEGERGQVKKLVEVAEKVNPLVISGDIYKLALPETSNWPAALYVSKDKSEAVLLAYQVRSTIMTVIPALKLQGLEEDATYNVNGTTYQGSSLIKAGLKLGWEKGDYLSKVVWITKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JER7</accession>
    <name>A0A1E3JER7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L198_03215</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032450.1">
        <property type="nucleotide sequence ID" value="XM_019175347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JER7"/>
    <dbReference type="GeneID" id="30192428"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="200"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="572"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODN99373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="643" mass="68435" checksum="4EA4616FCCD0EBB5" modified="2017-01-18" version="1">MSNGIEGQMSMHLSTPTARAHPAAETMSLSGAAKSYIPPHLRNRPAAPVAPPAAAAPAPAYRPSPTGLPTPATTPPTRSMPPPSAAAPGASGWDVPAARVKRTFDGGAPPGFGTWKDGKHIVGARNPRTEKELYGEVGDGLHQSTGINFDRYADIPVEISGEGAPEPVTEFTSPPIDPVLIENIMSSRYTTPTPVQKYSIPTIAQGRDLMACAQTGSGKTGGFLFPILSALYTYGPVAPPAEADSGFRGYGGRGRKAYPTALILAPTRELVSQIHEEARKFAYRSWVRPAVVYGGADIRQQMSQIERGCDLLSATPGRLVDLIERGKISLTNVKYLVLDEADRMLDMGFEPQIRQIVEREGMPGVEDRQTLMFSATFPREIQHLARAFLKDYIYLTVGRVGSTSENITQRVEYVDDQDKRSLLLDLLLAEQTGGLILVFVETKRMADTLCDFLCQRRHNATSIHGDRTQREREAALHAFKSGRAPILVATAVAARGLDIPNVTHVILYDLPTDVAEYTHRIGRTGRAGNVGTSTAFFNRGNLSIGRDLIELLKEANQEVPQWLVEISSESRGFGGSSYGGRGRGGRRGGGGGGGGFSSGGRDLRQSTGGGFGGGSRGGYGGGGPSFGGGGFPSAAGGSSASWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFC2</accession>
    <name>A0A1E3JFC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032614.1">
        <property type="nucleotide sequence ID" value="XM_019175511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFC2"/>
    <dbReference type="GeneID" id="30192594"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="600" mass="64405" checksum="C15A40EC1D41AE5C" modified="2017-01-18" version="1">MPAEGSTRKPRRSSTSFILPAINNIPQSATPTPAAMNGANKEGKDAKDPYANLLVNYYDAAPLFWPEFKDPAQAPLQLKGCLPNGLLPCPLGPGWSIDVNDLLILHPDKIKGQKGYTEWKLITCRACGKTYDGKNGRSVARRHLQDKHGMPLAAQSRRSRWDWLKGMGDGDGEDIHGKKRKRPSTAPRMQAKLEKHYSDFLLKFGPAGLATSYGLTLIAPKFRPAPGEIPAPFTIHPQDAGHYKIKPAAREQWIDGSYGKVIVPEEIARAVGAIWDGIDFAYAPEDAPTEKAVKMEALEESARGQAENSAVESNRDKQPSHGNGKDAQGEPSSQARRQAQPQSHNASQKPLPRTSNSAEIPSTMPSSNPVARAEPDTPSTEQSSIPPSGPIPARIPIVPIPPLPHAQASQPIAQPTPSTHTHAPEALPAAAPEAGPCVAQPRPNFSIKVQRLASDGQAVVTNPIPLSLRTSQSRSPAGPSQQIPPALVANQIPTSIHPIPNEFAPLDPAPLHSAGDWPTFVAGSQPLQGLPIGYHSFPQQPTPGHVLPNVAMPPDLGQMDDATRAMLFSQMQHSWDGSAGGREMGESFGQQMQMGQRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFK5</accession>
    <name>A0A1E3JFK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032689.1">
        <property type="nucleotide sequence ID" value="XM_019175586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFK5"/>
    <dbReference type="GeneID" id="30192669"/>
    <dbReference type="OrthoDB" id="2572975at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="566" mass="61471" checksum="4814A44A49931554" modified="2017-01-18" version="1">MQHSQSTYDGPLPSSFLPRAPFFTPAPSPNKAWQPSTNVPTPSSPPPSSQHRQVAARDLFLRGKGKPVATASDKILAAVKDLGSQISDLHSEVSSLKKDNRHLCDQLHELQLSVRCLPSRDEVTDEIINNITPELQECLQSTLSRFESTTAHFPGKVVEAIAPHLSNLQAECKRLGQDARPGKPGNESHSQPLHDLLSHVIAKLGAIETVGDSVQTIHNISQIAGDVALCRESLNCLPKITEEMEATAHKSRETLLSIQQSVQGLHHCLDRTPHSSQAIGDANQATATLKIRELLTLILTRQNEMKFLLGRLSALPLALSSSQRQYPTSSFPDFPASSQDESQPVMTTPVSEGHIGRITLSSRESSTQQDSSQSSLADDRPLVGDSLADIFGPKAFIPGPVRATSDRQDTRQGGSRMSVDEAEPPLPVLSYPQAVFSPSPMIEMVSNKKSHKRGRLQKKKQPITAQLSTITRLPLDDSAPGKHAPILSPGDEPRRQTRHSSRIAQNASGTQQSLPHADAESSLASRDTSKDGTAENKECPSQYRKVGQGGGSKAKKRTWDFSSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIE2</accession>
    <name>A0A1E3JIE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032832.1">
        <property type="nucleotide sequence ID" value="XM_019175100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIE2"/>
    <dbReference type="GeneID" id="30192174"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="33028" checksum="653EE22B76790BAB" modified="2017-01-18" version="1">MLRRQTRERREYIFKKSQESQERAIYERKQKIKDLLAQGKSLPTELRNEVRELGGKELVLDEAQQDPSALIDDEYAKVGTYDPKIVVTTSRSPSSRLLQFSKELRLVFPNSYRLNRGNTVIKDLVGACNSQGVTDLVLIHEHRGVPDAMIVSHLPHGPTISMTLHNVTLRHDVSSNSSTVSEQYPQLIFDGFSTKLGERVTQILKALFPVPKEDAKRVMTFVNDSDFISFRHHVFAKSSHKDVQLAEVGPRFEAKPYEIRQGTIDQTSADVEWRLRPYLHTAKKRNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIG7</accession>
    <name>A0A1E3JIG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032805.1">
        <property type="nucleotide sequence ID" value="XM_019175073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIG7"/>
    <dbReference type="GeneID" id="30192146"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="172"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="32169" checksum="70FC7A18A04D6F7E" modified="2017-01-18" version="1">MPPRPGTETATTDPLSSPQQHAHEEPFPSLPSLLTNQTSQPEPSSRPSHPHEETSHENQNGGQRRSFTVNRQSHANGHGGGPSAIGSTTVATGPGGDGTGVAAFGVGMDDWEQEYERQKNRGWDEKLEKDLEGWRGGHGKPRSAYPRQALPPMSYYHTPVTGVIGQHLPKEMVRIERDWTDGEVCQFETVFPIELDNRISPQALSSFINTLNAQLQEAYKPWPNALDNVIGIASLWTSLWWRQSHFEKVLQALEKYIENVNHDTFNPAGLNVLSPRDVALQFLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIP8</accession>
    <name>A0A1E3JIP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032953.1">
        <property type="nucleotide sequence ID" value="XM_019175221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIP8"/>
    <dbReference type="GeneID" id="30192301"/>
    <dbReference type="OrthoDB" id="2570790at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO00761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="593" mass="66185" checksum="6F339C0C401D31CA" modified="2017-01-18" version="1">MEDLSSLSNSLREILSAPAQDQESLGKVLKKYLDTDDTNVQQVVCEVILEVLHEGNAQTQKQRRTLLLEDHALDYTASILQVTHSSPEIVMPLIQLIAIYGKPREVLMAFSEALQYVVDRAEGFEVSDGEETDEEESNVNYDELWVEWQMLIMGLTIAIPRLPNTRSTPTLLSLQELLSSSIFSLGAHAPSIWPRTAILVLCRLTDTLWRWVQTTTDKNGEQASILSNILFEALAILGPKADAELTERWFLKTFPKYSQGPQVSTVSQDPAMDRETPQGWQQAAMVFNQALRVVEILNPNKPLSDRVFFSSSRSTYGTFAAFNLLASTIPDGKLNGLLPDPLPSTTLEDLMPVLCAALSGTSVDAGIVWLWWIVNESQNGKKGALNVGYEEVTMLLELLVPLTAQHASPTVRLALFKLVGTLVSLQEGRDKVLALRQLLEPENPFESVRVESLSILRQETSNSPEILNTDFLAQLNPILFPAPVPNDKTCPFSLQPEDLLRNTFYASWWTEVAQYVWFLSTRDKENATGIRSVYKDIVTRWLSNTRRQLNKVEEYVKGLDEATIAEVTGGQGADFLLAKWSDALDRATSSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIY7</accession>
    <name>A0A1E3JIY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033032.1">
        <property type="nucleotide sequence ID" value="XM_019175299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIY7"/>
    <dbReference type="GeneID" id="30192380"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="7">
        <location>
            <begin position="187"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="34981" checksum="8B26DA553DFECD48" modified="2017-01-18" version="1">MAHSDPYNDPYGRQQQQYNTSHAADNTNYGQQPYHYQEENPYGEEPRYPTYSSDPTAGDYLNSSTEKVADESYPQGNTARAQPGRSGMARPTTSFAEMGPPPRSTGILRVWRKDERGKQWSRGGGVRTSLRFCCCTITTAIIMIISVVLAVLLYIRPPSVTLNSATVDSGSVSANTDGLSLKFDLNISVANPNWFDANFKNIEATVSYPGNNTNNFGGGSMSNVNFKGYTDSTFVFPFTLNYTLANDPDRTVLNDLISKCGILGTTTEDITVDYDLNLNLKILGLTVNPTISNSASFECPITESDIESIVGSSGLSRLTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JJH2</accession>
    <name>A0A1E3JJH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032978.1">
        <property type="nucleotide sequence ID" value="XM_019175246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JJH2"/>
    <dbReference type="GeneID" id="30192326"/>
    <dbReference type="OrthoDB" id="2573087at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120936" checksum="C3585C92CF6F8DBB" modified="2017-01-18" version="1">MVEVHAAPRVAIRSSAKSAQSIVVVCFLILLLYIFFSGGRASEKLEKASKNLGKVGKNIGDAFSSREKPSTSSSNRGDRREATAPDSDVISDGGHDAPRSRKRGQEVEGGKRDNKQTSQEEDHQQAVRKNHHSRSSVQSPSRSDTTPIFTSDTSASTAEQDRQRQERRKKRKDKEEEKREKEKRDSERRDKGRRDREKRAGENVTESDTNETTERSDQEKIEKDREAKKKKEQEKQKKKKKEKKAKKQEQVEYEKPDSSPNLTPLPDHRSARPTRSIHRRRGSDDSLTPSRNSSSGSHVSWSDEEGKSPHPVTKHFRKWGDYVGLTEDKAPFENVPEKIEPKWQTHRKLPVDPAERCAKALRGKGILEDGVLKLMEEAEVVAMAKPREKHWIQALNDQWDNHHGSIPAVAVMMSQELSKLISIKDIELLETALEARKSAKKATKPKFDAKIDKKRDYGKFKDRVGVRPDDPLFVYKFILAWYCEHYRCRYYDERMGISEEPVPMMSDSKLGKTAQILGWMEYLGRLNMGQRLFIGLDLYGLSMRAQAMREGDGYRLDLTVFMPGGPPEKPENDPMKEWAIKLEDSGKAFRTIHFELATMLYKTEDDTMLKDPFVRRRLIFRPGWSLRGVRSDKLGKPEPERSVAQRTLIERPSEVLAIPNNINERITRALRKPSKNTRNALSRLSPGEVCFQSIRQYAWDKNSVTPENSKLTPLTFWIAWSFSGEKMQESKGPGDVHQDQRSHDFVRSIDLGGYIPLFKLQPPRFVPINGFPALEVLVLSYVPLGKAGATAELLLNKDYGLFDELKKIKEPTRHLSKQVTKLRLFISIADARSSRSIIEDLDKQLAEDGRRQLVGGKSPDQAVINMRGLARDALGEAFLVDEAQAGNAEEGLLPKGIPLRYDSAGAEKLLGIGKNHQPPADRESGQAPPSESNDTSAIPADPPAPPAQEGKTNQPPGPAPPVPVHLPSPTSELSGANLGGHPKRVPPAPVDPIPSGRSAGAAAEARRRALENEREAQPSPVDRRVNGESLNQDGQSGYRSPTVEDDPEGDESDVPKDKKSRFGSLRDIESKFRGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLA3</accession>
    <name>A0A1E3JLA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032904.1">
        <property type="nucleotide sequence ID" value="XM_019175172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLA3"/>
    <dbReference type="GeneID" id="30192251"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO00712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="811" mass="89553" checksum="38C4AB0732D31693" modified="2017-01-18" version="1">MEADMDASVMIDVSMGDEDGFDPATLANLAALSSIINDDDEPLSGEQTQEEARGETEEPLDTGGSREPLTREQVQDLMNQLAQRDKGKDKEDDARRRGAESQATSERGQSRADDGDEGEEGPDTMDDEEYGEYGEEDRNEKGKRKRNRTVLSCTECHRRKQHCDRNIPCSRCVKRGIPSMCQMEHPVLPQRKRKRPAAEDEALSHELVICAQSLETLLRGTDSYLDTNSTHAAVEVTIRDASRAAKAGSTEATNALQQLAQPLEGMNKEEQSKMLFEVLQLLAAASTGKALNAGVMGGDQRGLELWASVPSAAPETTVAVASAFAANEAPTKVNISLFGYRDVGGKLFIPPTVRYAAKQIQNEQLLLVEPLSIDGYAPFLDAGVKFAYGADSYPYRHKRIAAVQAVSLTGALRLAASFIASLPNPTPASSPRPIFIPTPTSHEDYNTLKSSGLDIRSFRFLDPRTGGVDWESLREDLSAAPVRSAVLLYVSGSMPSGAELSTTQWRLIASILAAIMAFQGLSSGDTTRDAQALRFMVHEGLPVVLLQNFDTTMGLYADSPSIVSIVVRSPQDKAKVEGQLRSVARGMWAHVSPWGARIAEQILTDAKLHPAWLNEIGKMNKRLISARGKIFQILTDKLKTPGDWEHIKKGTGMYCTALLPPKQAHALTAKHNIHLLPRACFNLACLDMPSIDLLTRSIDSVVRAGIREAEEAHAQRLAAELAAQAAKEQAAREEAEREQQREEAEREKARQEDTLLMERSIVQAMERQKQEEEEEKRKEVQRRRDEEMARQRREREEIARQAEAILATIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLU9</accession>
    <name>A0A1E3JLU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033080.1">
        <property type="nucleotide sequence ID" value="XM_019174701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLU9"/>
    <dbReference type="GeneID" id="30191768"/>
    <dbReference type="OrthoDB" id="10356180at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="74399" checksum="837427166E9080C9" modified="2017-01-18" version="1">MPRLPFIGSYDLSLFYNPHEDTSTLPAPSPDINQDLISSWPTLGPADGAGASTGTEGNGTSKRRSSSPKSFLRRRVDLFPPDGVNDTTTRRNASPISQLPSIPFSFIPDVAEQPEKMYTDARGESSKSGSLKKTHQDNHGASTSLDSQPVSVNLPSHILSTRKQTTVQPLPSPSAAANDGDTLPDHPSLEPLSIAETGQTQARGAGEEEAESIMGLEKGELGVVKEPGCDTTEDEYPPESSSRPAIAARSKASNTRTINLAGGHDTRPETIITSSADVDPMAATTVTEKPDGKSSDLTPAQPKLSLNQKKRQKKKTAEARKKAGMERNETGFWWRYGSSSGSSETTLLSRRAISRGHVFLWDHPITFLGPDFNVNAANAMYDSIADKPEQKARVDGLRRSEGREREGDSVYGKLMDNSFALQYPAGWRVVLEHIPFLKVSCDPNTNYVWDAQRRRGQLVSLKDIPDNTPLMVRAQEGFKTSHHRQKRYTEMRMTCHCAFCQRTPEQHKHSDQNRYNMALLNHAMQTALSSPDSSPDSSLPALLDNIEQTLLLMSTEGFVEMYHDAFQYGLAVCAACGDEESAKEWAKGVRDTACLGQSQVAGGWGEAERMVEDPKRHEQWGQRGVEEKGWGPRREVILKTIGEFDFHEWKKEMKEKHLGEYAYPPDLEDEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM51</accession>
    <name>A0A1E3JM51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033182.1">
        <property type="nucleotide sequence ID" value="XM_019174803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM51"/>
    <dbReference type="GeneID" id="30191873"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="386" mass="43612" checksum="8408C656AAF79C81" modified="2017-01-18" version="1">MSTTPVPSQSLLPLVIQADHLPAYHAPYPSRHPITKQRIVPLHISFQDFQNGLPPVGLITKPVLKALEKEQALKFFSLAKEIKSCDIKKDGRRVECGACSECLQKQKQDKSRAAYKLSVLCVFFAEEINEKGKEARTEAMADILNRWKAEGRFPEATKLWMDELFPIYAYPQSRAFKATNSTARQPFGNVAFEMERAGVPLFGCQAFGVHMTAYEGEGEDMKIWIPRRSADRHRSPLKYDSSVAGGLPAKHTPLEGLLKECEEEAGWPEELIRKYVKSAGMVSYYEIMEDGAILPSTYTYDLPLPPRSSPTYIHPSPNDDEVDSFELLPVQQVILSLHKDKFKPSSAMVTIDFLVRHGFVTPDNETNYQEIVRRMHRRIDVTGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM69</accession>
    <name>A0A1E3JM69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033202.1">
        <property type="nucleotide sequence ID" value="XM_019174823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM69"/>
    <dbReference type="GeneID" id="30191894"/>
    <dbReference type="OrthoDB" id="2574195at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="891" mass="97859" checksum="817FB4EE7FD1CCD7" modified="2017-01-18" version="1">MAPLRDSQSTYEPTTAPPTSPPPHYRQSDISDDLHERPFQYSTAGPPTVYSELETAWSQPTRVQLSPGQSLPSAQRTPIAYHDSPFGGIEEEGEDDELYHRSDWEDHDNPKTTATPWSRSSWAGPTTGGTGISRWGGGTTRGRVQEGQEWIPPVPSRASAPALPGKRSQEQVVYAYEQNGIMESPGMMTPHDVGRYSGSSPHYRSSPQRVSQFIEQDRRAIERQRDSTLPSIVDLQDLARPKVSSNSSQSIVSPGSAGSDPPIQQMQQAQKPALTCRGPYTHETTPDASNTWKTNRVSGESPKLMSPEAQQRLGRMSMATARYTLPPQRHGGSEFVPHSIRKASTSVPFMARSKIGVVYLSYRPFIAPLLALTCALMLTITNSTSTSSISHFLKIGLGVFKGSQGGGTGAGNGINLGAWGWCQSGVSDPQCESYSRGDFKNESGSFTIPGDTSLDNLSSLLTSLTALTWLLAAYQIITAFLHFYLFFSLSIPFSHLVTIPKDEVAKAEVDLRVKLDRQNDPWGEELREMGESGNERGGWVWWAWWAHRRSPLGCFFGFLVGALSMSTLALTFLFKKAVRNGTNSDDVHYGAGTYVPLITLMVTLDTFILSMWYLISIRSNLSTFFEPPDPSPTALLLPPSEARRMHHVRDHNGASFFAPRSTHAVADTANIGDGNGTKSMFYDPNAPPLPVTAQTPMTEELDPETVRWLAAYPSDEELVPLISDLRMGKLNDDFLLSEVGLLYLRPLVEGEEGQALLVPPKGAIRQELVEDSHLDPSPFGEENDAVGGVAHNGAEVMAATLQQTFWWTSLPSDCYAHISKCPFCRQRQEEAEAMERRERMEEKAGMTAVPWTGITGWTARETEAGGGVGESAMAVEMAYAMRKAEEEANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JME2</accession>
    <name>A0A1E3JME2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Syntaxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_02759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033280.1">
        <property type="nucleotide sequence ID" value="XM_019174901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JME2"/>
    <dbReference type="GeneID" id="30191972"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO02028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39458" checksum="843D817526F27B68" modified="2017-01-18" version="1">MSDIRDISVISTKQLDSPKPHTVYIIQITTPTRSWTVTRRYNDFVDLHTELKSSTGSEPPAGLPPKTWGLAFGKSNEEKVRQRKPLLELYLRTILNTKNPLWRTAYTFSDFLSVPSHSTTASAPGQSGGLKFTPQSWMLEHGAIQTLLRTSRSSLLKRDALASMSNASGSRSAAVEAKRHLKEVDAKLDVLEKGLKSLQGLGEGEARRREEMVEGLKVERQTLGRMAEAGVRTAAPPGGASLGGARDGSSNPWAPAGQTIPGALPSGRVFGSKAPPQETEQTRPLDDRQLLQYQNSNMEQQDEQLRGLSRLLQTQRRMGEEIHVEIESQNELLEGIEQGVDRTGKKVGKAKREMNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JN45</accession>
    <name>A0A1E3JN45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033328.1">
        <property type="nucleotide sequence ID" value="XM_019174949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JN45"/>
    <dbReference type="GeneID" id="30192020"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30762" checksum="F6DE7B3B50F9D06C" modified="2017-01-18" version="1">MITLTIVRHGESTDNLRPLWAGWADAPLSNHGMNQAKALGQSLKDTRFDYIVASDLKRAHWTAQQIQSNQATQPPLDTTQFLREQGFGEAEHQPFGNSDGKWYRKPGRTFAFPGGETLEDVRNRAKQAIEQYIEPILQESRGKPSSDKHVAVVAHGIFNSEFLGALMARRQGNAPLEWQYRGMTNTGWTRAEVGYADESGSSTTPKISTNPSEPVHPSSNPSAAPPAKAKDHALEPLTIKIISTDVTSHLSGVVRQKGGIGSQGYDAKQEDIRKFFGGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR54</accession>
    <name>A0A1E3JR54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033395.1">
        <property type="nucleotide sequence ID" value="XM_019174343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR54"/>
    <dbReference type="GeneID" id="30191402"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO03344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="925" mass="102002" checksum="B5CFB920D80DC85D" modified="2017-01-18" version="1">MDSMHPDPTPGIPPSLPDLKTQVARLEASHKEKGLPLSGRIIHVMHHLPVEIVRVVPADALEAAGSGVLSPPMTPEFKPEDAETTVESAKWRIHARTAHPALVSGIKSLSDTHDQVLVAWTGEVLIQPDSTASSQAPSNKGTFPSIADTLAAPFSGATEAPPPPQDGPLMVFGGEFNDTDRKELKSELDRFSQAESGKDTSEKLQYIPVFLPPDVSKGHYEGFCKKTLWPLFHYLLWLDSTATVPSPDPSWLAYEKTNQTFAHAVAEVYRPGDLIICHDYHLLLAPKMIREALGQPTEIMIGMFMHTPWPSSEIFRCLPKRKEILDGMLGANLVSFQTYSYSRHFVSTCIRVCGYESTPGGVDANGQVTAVGYCPIGIDIKRVIHDRDQAGVIPKMQALRALYKDKKIIVGREKLDVAKGVYNKLQAFEKFLQVYPEWRNKVVLIQVTTPALSESPKLERMTAELVSQINGTYGSLDFTPVHHYHQALEKDEYFGLLSVADLALITSLRDGMNTTSMEFILCQDKTAKSPLVLSEFMGTAPSFASALQINPHDLLGVAHAINKGLGMGEQEKVERHANLLEGVLGHTSHTWAATILKQLLENVGGEHTAHQTPALDLAKFVDGYKKAKKRLLLFDYDGTLTPIVKVPAHAVPTEQTRNAIAALAEDPKNVVYLISGRDGDFLEEHWGHLERLGMSAEHGSFVKQPGEDGFINMTESLDMSWMSEVEEIFKYYTEASLLASTTGSTIEVKKASITWHYRNSDPDFGDFQCKQCLDLLESSLAPRRPIEVLVGKKNLEVRPLAVNKGEIVRRLMYENPDADLIFCAGDDKTDEDMFRALRTIFPPGGIVDNKVVMKPPVAVTSTLEPEDVAELPDVELSIRPNEVFAIAVGPPAKKTLANWHVTCPEEVVEALETILDENVIGISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRA6</accession>
    <name>A0A1E3JRA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033462.1">
        <property type="nucleotide sequence ID" value="XM_019174410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRA6"/>
    <dbReference type="GeneID" id="30191471"/>
    <dbReference type="OrthoDB" id="10298089at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="482" mass="53502" checksum="6714D7F406F5D818" modified="2017-01-18" version="1">MCFSHLDQLASQNKCAPPIPPPLISNPRLLRPLRPKRLGVQYAPRSLLATYLRPKPSIYELCHCGMNNGGRYSEGSFVSRTKSYGPLNKPGHDLMLANGSAHKRVSLTSFASNGHRDKQYSCLGRPITPADTWPVEELLCASLLASRATITPPLACPVSTPPVIRERVFTPPPKIDLSSEEPLEREIFMQEIPGFATSQLEREIGLVAPDCASPHIVTDNEVLEVEVVTELSEGLDIFDEEDVTALFESESCGSHDLERSGLKKSVTFNEETEVYWFEISRGTSSEAHLDLSFGYESDIEDNLTPTQLLRKQYRIVPASPPPVEHREFWNVVASLGISSPLQDLSDTSIQSPTRNSLPSSLEAEQLSPHRQSLSRAEDASLDSVDEIVSRPEDQDIDLSSDTTPIPTQHISLHASSIHLSESFDDTPTKMVTAPRILSHTVRPPIMSLCPTHLQGKKNSRHPRRDRKPTLTPVLYARSTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRP2</accession>
    <name>A0A1E3JRP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033602.1">
        <property type="nucleotide sequence ID" value="XM_019174550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRP2"/>
    <dbReference type="GeneID" id="30191612"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24630" checksum="332133BB48944874" modified="2017-01-18" version="1">MPKRLLNSAVRLYNNNFQRRPDTTLIVTNGALNGIADALAQASSILLHKPTPQSPLAPKYDYARTLRFTIFGMAMGPFVGRWMSFLETRIPMGNIVRSGRVVLPGRVVKQRGGDNAQLAKRVLADQVIMGPIDLCLFVGSMGIMEGLSQASIIEKFQDVLALIADWAYWPIAQTINFKYMPLQYRVPFQSTCGIAWTVYLSILNADENKNLKEQHHTPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRT7</accession>
    <name>A0A1E3JRT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033625.1">
        <property type="nucleotide sequence ID" value="XM_019174573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRT7"/>
    <dbReference type="GeneID" id="30191635"/>
    <dbReference type="OrthoDB" id="3364608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="482" mass="52469" checksum="5284BE12F6A76A00" modified="2017-01-18" version="1">MESPPWMGNPGRTGFRHSGDEHRAKRRRGRNVDVIASPAYYNPLPTPETVRRPHKSKLASQPAHPPTPQTQRHIRRAPSPNLAADSHHTSPSNQATSDPSTYQTATRPEKTSRRRPGLMFAQQMGLVDSRGVGVGMGGHRLGHAKGALKAVKEEENPFLVSSDAPPAKRASMGAAMGLASPGAIQRRSDDEDSHSDADDAPAPSRLSLQSPATGLLSPPPTKHAPRISDPSSQTVRTRAEQASSSKHARQSIPLDMLDPEHNPFLEGPSEPARRRPGPSVDEDQATITYIFRGAKRVFANPLYHSSAPFPQADLQPEDEEFEPHPLPKPRLLWPEGPKESGKRINVQEIRRRGARTPSPGPSKRLLSYSTSASLLTPTTSTARRFGNVTRDSPNFGGGSSAFTDEELEQDAEGEEEESDDDEPFKPLKSAGAKLAELGKRGEEEEELPVRRGLLFGAGAGMKRDRDGGEEGRVKRMKGAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRZ8</accession>
    <name>A0A1E3JRZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_02455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033656.1">
        <property type="nucleotide sequence ID" value="XM_019174604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRZ8"/>
    <dbReference type="GeneID" id="30191668"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO03605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="31336" checksum="9AA7BBCAAB71175B" modified="2017-01-18" version="1">MPAPAPVTSLDGRLKMHDGYTIPQFGFGVYEIDDDETYQCVKWALEAGYRHIDTAEWYENEAPCGKAVNDFVKSSGVPRSDIFLTTKLKNNSTYDRAYADLKKSLKTAQVEYFDLYLMHSAIGGPEVRKNVWRAIVDAQKEGLVKSIGVSNFGAQHIQEFIDQNVPLPVVNQVDLHPFMRHPSIVKICEENNIILEAWGPLARAMRFDHPVLVSIAEEKGKDVAQVMLRWGLQKGYVLIPKSVSQKRIISNSKLFDWELSEKEMGEASRAVERDFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS17</accession>
    <name>A0A1E3JS17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033676.1">
        <property type="nucleotide sequence ID" value="XM_019174624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS17"/>
    <dbReference type="GeneID" id="30191688"/>
    <dbReference type="OrthoDB" id="2574175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="417" mass="47802" checksum="75A7D38354E5F7C3" modified="2017-01-18" version="1">MPRLYSPAPLRDMTTLDPLPTDITDIIFDHLIELIPLTLAVLSKACYNKLVPHIYKTVIIRKANASRVLYGMCLEQTAELPYPYGGLLFGKRKAKAFEYTKKVVFKDIWAAEALVLAAREFPTHEFGFMATENSYPLLFPHTTHLLLGKALLRSLPDCARDVSIAEQKRWETNHVLRFQDGATQKDKWVEHFGNWFVTAGEFEDLLFRMVDPEVICFDMQYVECDGNSMSGSRVTDAIGLHRPKGRVVIHWFFYSAEEQRPLFGEIAMSTPITIIFHTSPPPNEEITDPEIALAHSIFTSFTPLQAARELALAVDRMIEEILNFTDIISDDRLPGEEECESCEIELVLPQAEEVRRIWKWEGREDRTEEVVEFTETWERIVKFRDVQEVGACEACGRELEMWMDDRGRVQGYAGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JU17</accession>
    <name>A0A1E3JU17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033473.1">
        <property type="nucleotide sequence ID" value="XM_019174421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JU17"/>
    <dbReference type="GeneID" id="30191482"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO03422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="216" mass="23507" checksum="99EDCF87BDB4E778" modified="2017-01-18" version="1">MVPQTISGFFSPLSKESLKSGVTPTSSRTLHPILAKAETIYETKPDGFILTSVVYGADGDIPDIFIEVCSPRASHQSYKDRHDALVIQRILNLVAKNALASATEEGKGIYRTARQAKQAVHQAIKDLHGIHSKAGYFRFAHVHFRSFDKLKEARMATKPYITQGQGASVHLEQASLGERVVRAEAEKDAVCGEEEDVGHGFVGGQENGSLDSGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX39</accession>
    <name>A0A1E3JX39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_02093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034055.1">
        <property type="nucleotide sequence ID" value="XM_019174248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX39"/>
    <dbReference type="GeneID" id="30191306"/>
    <dbReference type="OrthoDB" id="2567960at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO05400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="101032" checksum="4CFDE86FEC911235" modified="2017-01-18" version="1">MEIPSETWKTKTNKVAQTLRIPTSWSGPSIVSPSLLSDALWTVKDGLFMCTCRTPHNEDHYLVEDRIVKALQNALLVAATNEAETPRCLEKKRIPTRSAALNWDKSFRQDEFSWDKEGMRVRIVTLDEVAMCSTRKLESLKLVEMTSLKCPDKHLDCVYVCRVLTKAKVEDGIVFQVEDPQGRVLPVQVKFPTATPCYALNLRSTLQEIYPVGAILAIREPEVRTGMKGGYVIIVDVPTDIQELHRSHPLAQMFKGVAPAALIHELTWEEVKDLGNKALKAKNPIIAAKHYTTALRYPEVTSDPSRQLTLYLNRAQAHLDQKLYGTAYRDCFHAERFVCDPDAPATYAQLAKLYWRMANAAYGLRLWSTAERLLDKCHVYSEVLEPLTAMKAKLETRKIERQYGHYNWTSILQDVQRSNAPCIDVADYQGPVDIRIIPKRNTRGLVSTRAVRAGELLLVSKSLLTSYSGDAGNAITPCIDHLNEDYIKPSSYSAISRAVHQYLDDPFSAQIFSSCDFYEHGALSMLPTWQCAEAKRLEELFKPVSDIDLRRIRNVIRDIKVHDSPVSLKATVIPRSTTNEESREWPLMVFGMPGVMVHSCRPNVSIKVWGDVAVVRALYNMPKGTELCSNKFDTSLTYTPRSEVAFEKGFKCSCSLCRSDAKTEYDLRFRLLEEVVPKLKADFHTMLMAKMDTGTPSGWNKGKEWVKVWMQMERKLMSTYADSNKWMRGDLVETRKMLMAAWLLLDRRKAIQAMKDAMEANGCVWSSADERMSHGRLLERICAGDDSLVKDLLYPVKSFSRIKPVSTETRAFISFWARTAFWAHQILFGGDLAFFKYRFSSELPAEQEGLIYWEYNEETKKYGNGIDVPANNAPIDVKFFQGGKQQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX40</accession>
    <name>A0A1E3JX40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034046.1">
        <property type="nucleotide sequence ID" value="XM_019174239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX40"/>
    <dbReference type="GeneID" id="30191297"/>
    <dbReference type="OrthoDB" id="10404456at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29699" checksum="7E5BA01E6D9A9859" modified="2017-01-18" version="1">MDDSNNRSYHPSYKHPSQPTDASVDLSTPYTTVTSRGIKNYYPPVPLEDVNDGFSATVGPPPSLLPTTDLNQNLGPRCLLSFVDPSLHIPQQNASSYHPFSKPQEPAWGTMIPTSHFPARSLSSFASATATADDHYGKSSLGSEPEEHEDDDPDEEEMVRLRKERTNAASVRWRRNKKIKDAQLRSRLADQEKLIDELNDSNSNLTTQNLELTRKLALAESELNGWRSGYATSRRAQEEEECTGWRGGARPRGGYAVDLARGARCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JXE2</accession>
    <name>A0A1E3JXE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034081.1">
        <property type="nucleotide sequence ID" value="XM_019174274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JXE2"/>
    <dbReference type="GeneID" id="30191332"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="138"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="434" mass="46627" checksum="B9DB14DF86B84354" modified="2017-01-18" version="1">MSDIFRKSLLSRLPDLPPTRAPWADEPLAEGDEEVEELAEESEGIGELPAGQMKPPKTRGPNKADMQDYSPLSASGYFDQAIEVQPTGSPCTFRVYLTPPSTTTSSNTPSGPNLGPGPAGPAPKIQTQQQTNPHGTYLICHHGGGSGGLSFAALAKEVKRVSGGEMGVLAFDCRGHGKTRTEPVELENDLSAETLLSDFISLIETIFPNPKESPSFIMMGHSMGASPTISSVPLLIQKGYLVPGTVVLDVVEGTAVESLPMMESILGKRPGGFQSVVDGIWWHVTSNSIRNPTSARLSVPSILTPASPSPSPSPNTSQTWRTPLLQTSPFWLSWYTSLSSRFLALPSARLLVLAGQERLDRELMVGQMQGKFQLDVMEGVGHYLHEDNPAALASTLITFWRRNTRVLVLPPKIGSAPKKSGEEEVVAVRPVGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYV0</accession>
    <name>A0A1E3JYV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034120.1">
        <property type="nucleotide sequence ID" value="XM_019173415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYV0"/>
    <dbReference type="GeneID" id="30190460"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="761"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="906" mass="98212" checksum="5F3EE90C497A39DF" modified="2017-01-18" version="1">MPPSTSPLTTHYALVIDAGSSGSRLQIYSWRDPDLERAEILREVQDAQSLEGKGKKSKGRWWWGGEDGYRIGKGKGKEREMEEKALRRLVRVGKGVEGEDWVKRVEPGISTVNPDDITEYLAPLLSHALQHIPPSAHANTPIYLLATAGMRLMPQERRDAVLKATCDNLRDSYPFQVDGPSDAGPCGESVRVISGEEEGMWGWVAVNYLMDGFGHAPTLSSSSDNLLPLAPLADPPPDSSSSSVTPVDVNHHSPTFGFLDMGGASTQLAFSPSPSELDSSGFPVEDLRTVGLKLLSGEEVEWPVFVASWLGFGTNRARERYTTALLESWAQAHPNPTGKDLSTPLPDPCLPSNLQTPSTSPDLPGLIGTGSFSQCLESLVPLLEHSTPCPTEHCLFAGQPTPRIDFERHDQRGFIGISEYWYTMEHILGVGGVWDWGEWEKGMSEFCGKQWGEIEKEREEDRFKSVDLDPTRLEMQCFKGAWISNVLHEGIGIPRLLDVGGNDTLTGGDVGDTNAEAERRAREKGLLEGAGNGKHHFQSVDEIGETAISWTLGKMVIEASKAVQPRDTVREGAWTKKLGLGLPAKLENRLEDMGIQVVWAYAFLAFVLLACAFGRKKRYTSTPGRRRKPSISDPYGSSSNATRMWPFSLWAQPEYSVEDGPIEPMLSAGKRSISAPGRLRLYTRRFSNLLFKHIPFLSPPQHQPSYGLSQPRSRPSSANLSQFIPSPAYSAPSSPRTSTGFFVPAHQAMYNGLMAAAPIGGRERNSLTPDTMSGVASASSISPVPSVGSSPPSMSRSTLNYGRPLKSRQNSYHIPQPASSPSGGWNDPPSSMLLSTPTAATSSSSSDPLSPPAAGVLTPTANHGSLQTGARDGLAGMLSRNSSRVGLNELGLAQRSMSRAGTPGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYV1</accession>
    <name>A0A1E3JYV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034148.1">
        <property type="nucleotide sequence ID" value="XM_019173443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYV1"/>
    <dbReference type="GeneID" id="30190490"/>
    <dbReference type="OrthoDB" id="10376248at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="290" mass="32894" checksum="C5ADFFBA12A03C4B" modified="2017-01-18" version="1">MGQKSSSQRRDRLAQTSVMRYSTPATVAQYHPPPPEQNPAVTNDIVPSPAINPPFDIYLNNRQDPFDRNDSSGLFAPTQHNFVIETFRGSPIISEAVGVVHHHANPEPIAHESIKLLKEGVTMIRNCDPSFVFLKEAEAIMRVVDKMVPKAEQLFELSESRRMSFAWIATVAFWTAEFLCGAYEFQHSSQPGLLEYDQFTPESIQKLIKSGFAPFARSGVYDDELVDDEKKTGESRNKRRKAVGKRMLADKKIMVKAFPAFVVRLKPPFPGTEYLREATRKQMCQRPSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ30</accession>
    <name>A0A1E3JZ30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034169.1">
        <property type="nucleotide sequence ID" value="XM_019173464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ30"/>
    <dbReference type="GeneID" id="30190511"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="258" mass="29458" checksum="61466F6A67DAA33F" modified="2017-01-18" version="1">MHPFPLPASNISPAFFSRPEQRTMTFLTAPPPLADTITLQVYYGVSSPWAFLGAPEIDRIAKQYGLTIYLKPITVIVENGGIRLKARHEARQAYHALDLIRTAQFLQIPLKSSPKYYPQPPGGIELSAQAIIRIQRKFGVGAREARRFSYQVQRCIWETEEGDHCDLEVLKMLGRKAGLEEGDVQELIVDRRGDARDEAVKEWNRNHVEALTKMLGIFGTPDYVLNDEIFWGQDRLWMLEARVKELLEHGAKPLKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ90</accession>
    <name>A0A1E3JZ90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034298.1">
        <property type="nucleotide sequence ID" value="XM_019173593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ90"/>
    <dbReference type="GeneID" id="30190643"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="89"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="38132" checksum="969339E50EEA49E9" modified="2017-01-18" version="1">MRPSRLIASTRPIAQTCVSSLPLPCTSLRPLTSTTLPPPSPAFTQIRANHSHSYTTPPSSQIKDKVPVELSYDVVEPSKPSPEAEGQSLVICHGLFGSKQNWRSLAKAFAAQLGMPVYTLDLRNHGQSPHASPHNYAAMAADVHHFFQARNLTSGVNLLGHSMGGKAVMAVALDNKLNGALRTLISVDMSPARGKISPEFASYTQAMIDIEEAKVRTKQEADKILQNTEPMLPTRQFLLTNTRLSRDGPEPHLVFRIPLQLLSKAIPQIGDFPYKPPPPVTDASPEWQGPTLFIKGEHSKYINKHNIPVAEQFFPNMKLEVLETGHWVHAEKPAETVELVKAFIQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZM2</accession>
    <name>A0A1E3JZM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034336.1">
        <property type="nucleotide sequence ID" value="XM_019173631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZM2"/>
    <dbReference type="GeneID" id="30190681"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="281" mass="29563" checksum="6C63901DA4C0586E" modified="2017-01-18" version="1">MSDAQLTGDRINEERAFIKRYTEGLASRKLEYPADYATPPDERPRKIPAVAVPVAAPPVSEGMDVDSPAPDTSISLTIKSLKPSLTIPVTAQLTDTVADLKAIVASSSSSAPAADSQRLLLKGKALADSKLLKEYTIESGATLHLMISKAPSTPSLSPPLSSSEATIPPPSSTAPNPPSLTITTSIDDASKAGTSMPLTVADQSAAPIGPQPEVSSATFHTTVSEPLFWQRVHALCISDFETEQEANLAWETMFVSLKGRLSASEVAKIRDVVGVLGMNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZR7</accession>
    <name>A0A1E3JZR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="3" type="ORF">L198_01518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034386.1">
        <property type="nucleotide sequence ID" value="XM_019173681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZR7"/>
    <dbReference type="GeneID" id="30190731"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="19230" checksum="3A9344D20CB070B8" modified="2017-01-18" version="1">MFARLAFARSIHTTPRLFSATETIEASLRNALKAAMKSKDKPAAACLKSILSDVTNAAKSGPNPNEPATQESIISVLRKGLTQRTQAAESYAPSSPSAHPENHASLTKEISLIRSFLPAAPSEEAVQAAVTKIIQALPEDVRSSKGAAGKVLQTLWEELGDGKAAVDKKAVGKWVQDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K040</accession>
    <name>A0A1E3K040_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_01623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034491.1">
        <property type="nucleotide sequence ID" value="XM_019173786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K040"/>
    <dbReference type="GeneID" id="30190836"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="588"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO06391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="720" mass="81241" checksum="D0FD5512B9E6042A" modified="2017-01-18" version="1">MKGLKKAMNLSRTKSEKSKSPNPPAHKPQPGGSNPSSPSVNSPNRPAADQGNGQSQGASSSQGLQGGAPITPRRSPVSDKTSPAPPLVVISGAPQQPPVNSEMPSDPIPHSPHGRYGSPERNLGPDGQPTPPKAGPLNRLRGPKDTIPVVGKTPRKQRSSRFYVTEKVEIEKLPGFNEVRPEQRNELFVQKLQQCRVLFDFNDASSDLEGKQVKSQTLHEMLEYITTQRGVITEAIYPEVVNMFATNLFRSIPPQVNPTGDAFDPEEDEPVLELAWPHLQIVYEFFLRFVESPDFNTNIGKRYIDQSFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSISHVFFQFVYETERHNGIAELLEILGSIINGFALPLKEEHKTFLTRALIPLHKAKSLALYHPQLAYCVVQFLEKDPSLTEEVVLGLLRYWPKVNSPKEVMFLNEVEEILDVIEHSEFIKIMQPLFVQLARCINSSHFQASRLSVAERALYYWNNEYIVNLMGEHISIVLPIVFPALYQNSKSHWNRTIHGMVYNALKLFMDMNQEVFEECQNNYREQRKAESDKALERYDEWIKLRSQATTNWHQSHPNAPLPTSLTEPPPERPEPYEEEPIMDVSVDMTANGFDPSESFTLDRSMAEEHVPLADPGVDRAPMSPASPTQAGPGHPQQGGPADGTPPHMRRKSVLPMDAGVMRDLQVSKYALLDTAVADDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K276</accession>
    <name>A0A1E3K276_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_00819</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034717.1">
        <property type="nucleotide sequence ID" value="XM_019172991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K276"/>
    <dbReference type="GeneID" id="30190032"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000008">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="12">
        <location>
            <begin position="250"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="451" mass="50006" checksum="53F993ED5DFADB75" modified="2017-01-18" version="1">MGRSVREIVHLQTGQCGNQIGAKFWEVVSEEHGIQADGSYKGTTDSQLERINVYYNEAAAGKYVPRAVLIDLEPGTMDSIRGGPLGSLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRREAEGCDALQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMCTFSVIPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICSRTLKLNTPTYGDLNHLVSVVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTARGSASYRAVSVPELTQQMFDAKNMMAASDPRHGRYLTVACYYRGKVSMKEVEDQIQSVQVKNSAYFVEWIPGNISAAQCDIPPRGLKMSSTFICNSTSIQSLFKRIGDQFSAMYRRKAFVHWYTGEGMDELEFSEAESNLQDLVSEYMQYQEAGADDEIYGDEEIPIEEEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2C6</accession>
    <name>A0A1E3K2C6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034646.1">
        <property type="nucleotide sequence ID" value="XM_019172920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189961"/>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1365" mass="146349" checksum="C28FEE43A82B6C84" modified="2017-01-18" version="1">MSSTVSPSKRRSKQLEEEVWDDDFEFPVQKKSSISVTKDEKSRKSLGDDWDEDWDESPPKPVVSSPSRHGLSQSRPISKVPAPLNIPNHGYDQSRISPGLTADLSIPSPSPMLLSSSNPHQPLLASRSNSSLSIGQDPKPRSRAGSVATTGSGTVRRKLVKRHPSTSFISMPGNRSASHLPSSASSTSISSSHNIVSPVEEFPVPPLPANMPRSTSGEQMPPPPVPGRGESGVSALMRRKSKSKKQGARPSPSKEKSFLGEGKEQRKGFWNRLSGEPTEADGVHSHRRRRSSSVGATLAKPDSPQPPMPPLPSNLRSPSATSTSTSSSSHSHNRAQGVTSVFTSMLRRSSSSLSKSSRGSKEPPSAYPYAYPGGDGGRSRSSVSVGIPIPEKTDGRTTPEQPQSFSRGFHLPSPSPHSPYHSKPRMPLPLGRPPLPHHTSSVSLLSGKPPSLNTMSIDADDSDEEGDKTPRRRKKVPLASLQTSPGKKGHGESYEHGSPASASIPGLPRSSSTSPWPSLGSPTKTRVNPMPLVPSGGGGENESISSGHTGASGNGSGFASTVRRLGSISKKHGRRLSGGWKFGTQSSNSSSNSGGGVAFAGSVFGQPGDERAVLETVVGSPVKDRRDDDLVDSPVVVQHPLTPDTKSKPKHRPRPSDQWDQDFPSFSAPNANQSSTTLARLDKVEKSATQEKLLLAEADKKRMEDKQKRRQSWNDFVIPRNVLEKQKELKEGIGAVKLFARGVNTLKTLSATHAGLRKRIIEDGSETDANKFSALETEFAQWWEMAIVLIEVGSTGKESGSQASVESPRRERRVTLASEEARAAGDALRQASGGSFKSPYNSPVQWNYETHSQIVGPSQKKISLPDPSETSQSTFHGPPRASPLPEQWRASTGRQDLSKRQLEVLRTMLKTPMPSGSVSSLERPGMSRGASTISMRTGSSLAERFDAVHGPGTATVAAPPMPRTHTPLRIDTTSPQGLVVEPPTATANLDQRRMSKAGLAGLKEFLRFLKKDGGGEKKPTPRRMKSHSKALRDAPVTSPSDKIDYRGKSSMSPPSSPSSPTTKQWSRMPQTAPPTQTTTRGPYETSRSSFSVFGPQGPSPLPTTGSVSGTPQSQSSSRISWQAQPSASQASSQPNPKRPSLRNIFRTSSGNWSELAANSTPNPSNGSPGLRKRGSVQILGQINETMGKSPQQREDKERERAHAQAQTMGSLTGRVPGVARSSISVSDPLPHPQVRSVTEMGARVKGESQGEGDQTLKPRRKGRATPLGLGLGWPEKRAEEAGLARSPTSPLRGRPHAASTSTMNSATTGGGETGDEELVVALTPENLPTLLEYLRQCEMKLGEWKELVEEEGLGEKLVEVEKGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2E4</accession>
    <name>A0A1E3K2E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_00742</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034640.1">
        <property type="nucleotide sequence ID" value="XM_019172914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2E4"/>
    <dbReference type="GeneID" id="30189955"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="383"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO07163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="734" mass="78756" checksum="5E08C8ACC402FC71" modified="2017-01-18" version="1">MSLLVSNSSAAATAHSVASNMVMTATLASASATATAVNQTKIIALENADQASTNMAMPGVIYLAAGGLLIFCMLLGHTRFLARLFASFPKSKSWPSPKSSGDLQVTTTPDLSARAVGGGDLKTGWLLSKGPERNIEIFSPCTPATAQTSGPFSPYHDARQHGYFPSVARPRLQPPPHIVPLLHYVPWSSSLISMPFYRLPSHLKSLASMPALYVVLGYLLCSAFALVWKSKLAVASADSGYGSDFKRSGIVGVAQLPLVIALGVRGNVVGLCVGQGYEKLKLYHKVVGRVFFAASTVHSVGYMYTWASAGILQTHSAKPFAIYGYVAFGALILVTLSSLPFIRKGYFRLFKFCHFIGMVATLVGLAWHIDSAVPYCIAAMVFYFVSALCSLTKTRLATAQLHAVPSSDMTIITIPELRSGWRAGQHVRIRVPNLGLRQGLEGHPFTIASAPNGEGLVLMCKRAGDWTTSLFNLAQNLQTPDAEAQQGQGVTIVLEGPYGGLGNTMPSSFSSVVLVSGGSAITHALSIAHDLVLRAPTGSVRARTVDLIWMVRTEQEAKPLISTLTELVDDARAWETTCIENMKWGDAYIPPTALRVKIFVTRCPASSPITLLSDIQTGEKVNVDLSPADQEKMSYLARNPSAASTMTCKSRRNLPFSSIAANPARPNLGILMSSIADETIAHHGRSLTNPSGMFVSTCGPDGLMYDSMLAVMKMEEYRATGVGGVEFEEERFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2H1</accession>
    <name>A0A1E3K2H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034855.1">
        <property type="nucleotide sequence ID" value="XM_019173129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2H1"/>
    <dbReference type="GeneID" id="30190170"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118581" checksum="3048410C889E45B4" modified="2017-01-18" version="1">MSHTNEVPLSPRRSIPPNDPPSHSRVRRGPDTAASGIDAEHLPRQQFFPEGSDGDEDFDEEDEGDDADVFAFRRPATAAQPGGVKASGYGTAPAPVAARPNTGRPATGAVSWAPSPLEETHESTEHVGSSTGPGTISYGDVPTLPLQDTPRSVNPNPQEKDNVPTPTGVIDIGGHLPYTTYDKANPPPFSGRNNPNNSSFAFNMSNPPKARRPRTGQSLLDKIQRRRKPETGESSITTTTGLTGGEGEHDADGFSDIASLPGINDIVPHSARRRSSNTKSMMSGSSFVTESEVTSDDRHTRRSRRFSRGSIGLTEMTGDMTVPDGKTTWGDGYGGRKGEEAEGDSMADLDMDMVEEDSPYPEVRASVSNIDDPDMPAMTIRAWFLGILFTILASACNTYFHFRTPAPYISPLIVQVCAYPVGKFFAWCLPINDYTLPRWLGGAEFSLNPGPFNIKEHTIIVMMANVAIGPAYALYATVSSELYYGHNWGIGFSIMFLLATQMTGFSLAGICRRFVVWPASMIWPANLVVATNLNTFHAEEDGFTGGMSRFKFLIICGSSAFIWYFFPGFIFTSLSYFSWVCWIAPNNNIVNELFGVSTGLGMGLLTFDWTQVTWIGSPLTTPWWAAVNIGVGFVLFYWILTPILYYTNVWQTAYLPISVVQLADRFGSTYDIYNVLTEDITLNETAYAQYSPVYLSASFSVTFMVAFALSTALIVHTALYHGPRIYRAIVNVKTEADDIHLKLMKMYPEVPDWWFLALFLVVFVLAVVSLEVYHTELPVWGYIISVLLPMVYIIPSAFIYAMTSQQVTINLLAELIPGYIFQGQPLPGMIFKVFSVQSIVEALSFIQDQKLGHYMKVPPRATFIAQLTATTVACFVQSGMKELLFHVVKDICTNAQKSLLTCASTKTFFTSSIIWGLIGPERLFSKGSVYYPQVFALVAGAILPIPLWFWVRKYPRSIFRNMNFPVMFSGSLAIPPASGINYSSWIVVGFVFQFWLRRKRFAWWSKYNYVLSAALDVGTALSAIALFLFLDLQGASLSWWGTNVHQNTADWDGIGATYLTAPAEGFGPSTWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2R0</accession>
    <name>A0A1E3K2R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034750.1">
        <property type="nucleotide sequence ID" value="XM_019173024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2R0"/>
    <dbReference type="GeneID" id="30190065"/>
    <dbReference type="OrthoDB" id="2569915at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="97" mass="9938" checksum="BE36FD41D3E53EC5" modified="2017-01-18" version="1">MAEDRKKFAAPPGVGAGRPDHPFAVTVEEPIPNAIVPDGYGIKYHAYHTITEGVFLPAGTSLPGGAVLPMSSVADFPMVLPLGTKLPGGVMVPVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K306</accession>
    <name>A0A1E3K306_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034997.1">
        <property type="nucleotide sequence ID" value="XM_019173271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K306"/>
    <dbReference type="GeneID" id="30190312"/>
    <dbReference type="OrthoDB" id="3255427at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="433" mass="47730" checksum="820129662990C882" modified="2017-01-18" version="1">MPLHLPKIIHRRSHSGTESPFINNTRSSSDDSQPLPGTSPSASLQSAGSPVLASRSPRPVSFMEQSRRESSQSGSQLHGILRNGAPSVNGSDSASGNGSSGGSALASLHKRMGSLTFNRTNTIETMFSLDGDTDRDEHPRREDSTEPSSPSTAATSVSSLSQFCPLPDTQGKGFPFFMMTLSSVSTLSFVALPPLLRTIVLDAVNRAWKRGVSKIQEVDYQPELMRRHKEKGCEGGVWEVTFRGEAWMPTSSEQVSSKRIILNLLTEFARQGYSLTSSFRTSAKDSGKDSLVFLRSSAPPDPEPVFFAVAFYSHDRIWIIDAEAEVGQAVEEGIKSWWMDGVRDARVRERHCRELRLRGAPWSAHSTQGLISSRVIHLTIMKIITQRAMGYDFVGSVDMADKEEAEMPVTFYRRRWGPSTRAVWGEVSEETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K437</accession>
    <name>A0A1E3K437_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035060.1">
        <property type="nucleotide sequence ID" value="XM_019173334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K437"/>
    <dbReference type="GeneID" id="30190376"/>
    <dbReference type="OrthoDB" id="2573468at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="122" mass="13022" checksum="4394CFF10356298F" modified="2017-01-18" version="1">MSSTTITLSTRPTSTTKPIAIPSSKSHSQAQTKLRSVPSLDSGYFENNSPPPSPPPTAEERLSVPMLADEAIGLLEKQDAKVGFFPLSCWGAARLSRPHLESAYRTPGSAQVACRVSSHLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K438</accession>
    <name>A0A1E3K438_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034784.1">
        <property type="nucleotide sequence ID" value="XM_019173058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K438"/>
    <dbReference type="GeneID" id="30190099"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="556" mass="61211" checksum="23A350019337E0A6" modified="2017-01-18" version="1">MSSQLDYEKAHANVALSAQERRRAALAEIDEAKFSWFHAKACIVAGVGFFTDAYDIFSISIAATMIGYVYHNGGSSTTNQDLGVKVAHSIGTFFGQLLFGFLADHLGRKKMYGIELVIIIIGTLGQAVAGRAPGINIYGVLIMWRFIMGLGIGGDYPLSSVITSEFAARRIRGRMMTAVFSAQGWGNLASAIVSVIVVSAYKSSIHSEPLTDLRAVDQSWRLIIGIGCVPAVIALYFRLTIPETPRYTMDIERNIKQASQDVDTYLTTGEYVVDPIHNNERAEVPKASWKDFCRHFGKWENGKVLLGTSWSWFALDIAFYGLGLNSSTILTTIGFGSSTTLGTKQENIFQTLYNVAVGNIILSVGGLLPGYYFTFFLIDIWGRKPIQLMGFVLLTIIFVCMGFGYDKMLSTDSGKKAFVFLYCMANFFQNFGPNTTTFVIPGETFPTRYRSTAHGISAASGKLGAIVAQVGFSRLINIGGKNKFLKHILEIFALFMLTGVFSTLLLPETKGRTLEDLSQEDQEHFVQDSDIPAPLVSKRRPAVSSEPDDEKVMHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4U3</accession>
    <name>A0A1E3K4U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035004.1">
        <property type="nucleotide sequence ID" value="XM_019173278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4U3"/>
    <dbReference type="GeneID" id="30190319"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="430" mass="47898" checksum="C7389321D8B00359" modified="2017-01-18" version="1">MSILSYFTARSPTIQVFLIALATRIIHLSILHLLTRLVPLFDSSPELLQHSPLPGLRWDAIHFASVASRGYEYEQQVAFQPGWLGIMRSAGEVVRWVRGAAVVDIGDVVLGGTIVANASTIGATVVLYKLSTHIFDPTYAFITCLLYLLPPTAILGSSYTEPLYALLTFTGIYMLAIEKQMFISALFFAGASSIRSTGVFNALFIFAYYVCGSVALDDPSDLRLLKGVVLRTAETMPSNLLVIAPFVAFQWYTSVGFCTSEAMSADTARPWCHNDPRLSYSFVQSLYWNVGPFKYWTLAQLPNIALALPILYSSFLGTSTFLRSFFRSTIFPNPGRTLPKPARPLPELYLVHILTMALLLFASHTQIALRVSLGDPVVWWNVVGLAFEWDKREKDGRLEMTQLGRCWVGWTVVWGSVAMVLWAGHYPPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K569</accession>
    <name>A0A1E3K569_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035205.1">
        <property type="nucleotide sequence ID" value="XM_019172263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K569"/>
    <dbReference type="GeneID" id="30189288"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130761" evidence="2">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="189" mass="17135" checksum="9A307561AD728A34" modified="2017-01-18" version="1">MRFAATFSLLAAVAAVTVNAAPAAESAPLSLSSIPGSPSGAPFGAASGVPSGGNFSAPSGNFTGGGGPIDNSTAPSGGDFGASPSGGNFTAPSGGNFTAPSGGNFTGPPGGGNSTDFPAPPQNGTAPSGGPSGAPSGTPTEGSSLLLASADKEASATAASSAVSSGSAGVVDVDESSPVSSSASASITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5X5</accession>
    <name>A0A1E3K5X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035346.1">
        <property type="nucleotide sequence ID" value="XM_019172404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5X5"/>
    <dbReference type="GeneID" id="30189434"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="277" mass="29632" checksum="AB9AA53CB68E0E72" modified="2017-01-18" version="1">MGQGSSSLPSSLPDLALHCLRVADNSPVDGLVEPYFDYLVGVQIHSSPNEPTSTSSPSAFKGTGEREGGIGINGVGDDQALRPEVLGRILEDNEGKRIGLRVYNAKSQRVRDVYVTPSRAWSEEQTRQNGDPDAKPSLLGLSLRVCNPAHALESVYHVLDVLEGSPAEMAGLVPWGDYVLAWSGGPLHSENDFYKLIEGHVDKPLRLFVYNSDLDNLREVILYPTRQWGGEGLIGCGIGYGLLHRIPRPSTPPSGPDSGADGYFGNGVTSGVLVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6F5</accession>
    <name>A0A1E3K6F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035623.1">
        <property type="nucleotide sequence ID" value="XM_019172681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6F5"/>
    <dbReference type="GeneID" id="30189714"/>
    <dbReference type="OrthoDB" id="2745718at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="736" mass="83559" checksum="EB279DEB38458776" modified="2017-01-18" version="1">MRSPPLLALPPEVLEQVFLALALPDSLRFMRTCSLLRDIYNASAHLHYLALLQTSAYVDCLAQSSTPLDRHDEQPLSPTSSAPGTPIARRSNKPLAWRSPHTGKLRSTVSSVTLPPWPNEPPQSQPFSYPTSAAEKASKLRDREKRWETVDFREQRLLKVRGREGVYELQEGIFLLCNDVSDEEEDKPSSIRLIPLPSTDDPNLEDPPIQTKANELQMSISDLTMDPSQDLIVISEYNPASQDAMHPTPTHRYHLLSMSTFKPHPLATFPTLDFPPRTDTLPRTRQLLQVMGDTLAVLVAKYIPFWILNAFNIGNIWQRTHEEELVFWNWKTGRVLSRFPFTEKIWFSSFALLSPTTFMVTNTSLTIPYAGPPTPGISARDRRPTVQVYSIATDPLHMVIPSQPLQNEVMDDTTPRPVLLAVLEMPKLDSDVQVAGFDVRPDPPFPARPKDKAGQEPAPTLTRHKPFTQDPSKGIMVLDFVLTERVVLGENAVDRIETWPFELFLPRETLVKLGEEGEERLRDAWSAGGWDGLGVRGAQRDLEWEEWGEKGARLVDKIMPKRSWVCSCSGYRYISILPQDKSPFFEYDLDDQAPDDDPPQRDPNIPYDPQPSHIMLLDFSPYNVQKELSQTVPYPDSDDVEPPRRRQWAGETFVPPFTQGEGWKSRVVTEPTVLRKKNVWEGDVVSGLPYREVWREYGGLANGVMIDDQRVIVIKTKAQRNGDWSSISQEMTILCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6R2</accession>
    <name>A0A1E3K6R2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_00337</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035462.1">
        <property type="nucleotide sequence ID" value="XM_019172520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6R2"/>
    <dbReference type="GeneID" id="30189551"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="768"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="465"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="533"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODO08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="812" mass="92726" checksum="1D4AD40BBB0B49EB" modified="2017-01-18" version="1">MQRGTAPPTTRRHTPDYSPWNHRVPPSAYGSASHPNPYTDTPPSPGDQLHSALPLHMDDTTDLKRRLSEKQPLNEPTHGELSLDDDSGKWAKGHGAGPGFGGRRGLPPKQRIPGWKGFAIEHEEWVWAGIYTFLSMLTRYWRIGAANYVVWDEAHFGGFASRYLNREFYFDVHPPLGKMLVGLAGLLAGYTGNFDFKSGVQYPPDVPYTAMRVILATFGVALVPLAWFTAGELGWSRFTRHWVTICVLCDVGWLCISRFILLDSMLLFFTFTTTLGLVKFHNQRHDAFSDDWWIWLVFTGWSIGCVCSVKWVGMFITAVVGIYTIQDLWAKFGDLSMPFRTYVKHWVARIGALMVIPFLVYAACFKAHFMVLNRSGPGDAQMSSLFQAHLRGNDFGESPLEIAYGSKVTLKNYGYGGGLLHSHVQTFPVGSLQQQVTCYHYKDENNNWDIIPPWYADPIDPDGPIHFLKDGDVIRLVHTQTGRNLHSHNIAAPISKEALEVAGYGNQTIGDDNDLWVVEVVDDTRPSKSAKEDGKIHSLTTRMRFKHRDLKCYLRAANGVLPQWGFKQVEVTCTKENNPKDPHTYWNVESHWNPRLPAGDVKLYKSPFWRDFIHLNVAMWTSNNALVPDPDKEDILASQPFDWPLLHLGLRMCGWGDHQIKFYLLGTPIIWWFSTASLGIGLLLAAWYVVRAQRGYKDWGKGEWEHWLWVGQVGFSGWALHFLPFLIMGRVTYLHHYLPTLYFAVLIAGHVLDHFFFSSRRLSQKQKIIWFALWAGGVILSFWWFKDLALGIRGSVNDHHGWDWRSTWNIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6W4</accession>
    <name>A0A1E3K6W4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">COPII-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035779.1">
        <property type="nucleotide sequence ID" value="XM_019172837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6W4"/>
    <dbReference type="GeneID" id="30189876"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130803" evidence="9">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="199" mass="22661" checksum="0568B5C9C1DF9E0D" modified="2017-01-18" version="1">MLHRATSIFAFLVLLLVPLAAFAHRLELEAGEKECFFETLDTQDKMTVTYEVGGGGHLDVDFYVMDPNGNVINKQDRKPQGSFSIQVDKPGRFTYCFSNEFSSMSSKTLSFNVHGQLFMGDEEQIAPVEQEIRDLSAGLQLVKDEQAYLVVRERVHRDTCESTNSRVKYWAIAQIGIVLAVCAWNVHYLKSWFEVKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6X2</accession>
    <name>A0A1E3K6X2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035745.1">
        <property type="nucleotide sequence ID" value="XM_019172803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6X2"/>
    <dbReference type="GeneID" id="30189842"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="295" mass="32788" checksum="EEF659FF6EDD382A" modified="2017-01-18" version="1">MTPSPRPLVIWHGLGDTALSPGISNFINRTQEIHPGIYVHSVQVPEDGTEDDERKAGFWGNAVAQSLEGCEQIKAIDELKDGFDGIGFSQGGLFLRWYQQYCDGPPIHNLVTFGTPHYGISALIPCPTPPTLSCLLAARAARAGIYRPWAQEHLVQASYFRDTERLEEFWEINGWLRDMNGERPFGRGEDEGGQGKRGEGKGLGALDNLVAILFEDDHTVSPAQSSHFASYAPSNKSEIIPLHDQDLYKDDWIGIKSLEEKGGLQLEKCPGEHMEIGGEKGCGERMVRRWIGWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8E8</accession>
    <name>A0A1E3K8E8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine-rich RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035359.1">
        <property type="nucleotide sequence ID" value="XM_019172417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8E8"/>
    <dbReference type="GeneID" id="30189447"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="13810" checksum="590A7538E8F3436B" modified="2017-01-18" version="1">MKDRETGRSRGFGFVTYGTPQEAEAAIAAMNEQELDGRRVRVNLANSRGAGGGGGGGYGGGYNSGYGGGYGGGQGGYGGGQGGYGGGQGGYGGAQQGGYQSGGYGGQGGYGGGQGGYGGAQQGGYQSGGYGGEQQGGAQGGYGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJF1</accession>
    <name>A0A1E3HJF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_08058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000051">
        <property type="protein sequence ID" value="ODN76463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027978.1">
        <property type="nucleotide sequence ID" value="XM_019180031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJF1"/>
    <dbReference type="GeneID" id="30197269"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF54">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN76463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="515" mass="56635" checksum="533E6A24AE915F38" modified="2017-01-18" version="1">MSTVDRHPTTTALEDEKDLSTTHEKDIVVAEENPEYIEFLALSDLYQGDALNKLTKKIDWHVLPQLVFIYLLSYIDRGNVGNAKLFGAMQDMKMDSKMWNLGLSLFFITYAFAGPPCSILLKKLGPKLVLSGVLLGVSLILICSGCSGSIASWFPLRLLLGLFEAGMYPGCAWVLTTWYTPDQIHSRHTIFYCGACLAGAFSGLLAYGIGQLDYTWGYRGWRFIYIIEGVFSTCVAVGAYFVLQETPAKQGGWLDDQERRFLVLRNKFAYGKDKGGSADTLNKKDVLAALTSIHVWILSFGYFCVGCWVYGLSFTIPTIMNNMGFTAADSQALSAPPYVFATFCVVASGWFSDKYKTRALATVLPALMGFIGLLICVLSVTHKHLVALTYVGVCLAQGGSVCLSPAFSVWTSLNAAGSGKRAVAISVAVVWVQLGGLVGSNIYLANESPAYHTGFGVSLAFLGLGNIVTPILYWFLIGHINGKRDKMSEEEIYEKYTAEELQEMGDLSPLYRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HLS6</accession>
    <name>A0A1E3HLS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L198_08034</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heteropentamer composed of five different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000050">
        <property type="protein sequence ID" value="ODN77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028006.1">
        <property type="nucleotide sequence ID" value="XM_019180007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HLS6"/>
    <dbReference type="GeneID" id="30197245"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="146"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="286"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="492"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODN77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="711" mass="78647" checksum="F183D0AFED666F72" modified="2017-01-18" version="1">MAFPRPKPTTMETLAVERADPPFNVRKLAIKMHGSERALLLKEKFMAEIARHPAFKLSDIHDLSKEELRERTMEKFSSMVYFVTTESLEVFGLRMQLISMADPSFWTRFGVAYGLFLGALRGGATPNQFSYWIDKGVLGLNGVIGCFAMTELAHGSNVAGLETTATFDRETDEFIIHTPHLGATKWWIGGAASTATHAAVFAQMIIDGKKHGVKTFVTQLRDTKTFQLLPGITIGDIGKKMGRDGIDNGYIQFTYVRVPRAHMLMKHTQVSREGAVTEPLLAQLTYGALLAGRTTMVTDSSTTAKKALTIAIRYAAVRRQFSTGKNEVETQLLDYPIHQRRLIPLVAQAVAIGFTGLRLTKMYEDMTQALDTMDPSDPNLGATLDKLKETHSTSAGLKAFCTWACLDTIDKCRQSCGGHGYSAYSNFPGMYADFAVQCTWEGDNTILSLQAGRSLVSAWGDAMKGKKLVSGVAFLNDRSVLTATSDSSLSLTDIQRAWHCVAANVIKKAAEEYLSLMKDGKTKEEAMEACSQSRFVAAKVHVIGYIFGMFREAVEESGKGPETEVLESVCKLYGLWQIEEQQGYFLKYGYYTPEQIDKVQIAVSALCADVRTVAVPLVDSFALSDHILNSPLGKYDGSVYESYFAQVQAANPTPKVHPYFERLIRPLLERQNEEMQDPGSEMGLDEELGAFAAERKEAAKGKLGKVRREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HS32</accession>
    <name>A0A1E3HS32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000046">
        <property type="protein sequence ID" value="ODN79160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028127.1">
        <property type="nucleotide sequence ID" value="XM_019179891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HS32"/>
    <dbReference type="GeneID" id="30197121"/>
    <dbReference type="OrthoDB" id="2577952at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN79160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="269" mass="30658" checksum="EE6405DCB8CC4BF2" modified="2017-01-18" version="1">MSTTSNQAHSGGEWAGELKEYTVNTMYYYKGNVHFITSDNVLFPFDLDRLAKVSSVFRDLRNIPQPSGKEIGAPISGQTILEKLNELSLNEREDISRHTDAVIIFPECNAKALQPWLNLVSDGGAYGSGLRISCEDCKELYTLMDKYGCDDSLYEVLRSQLSFMGNDRPWDLFIMASHGNDRVLGSRVLQSMSNDTFFAGGFVSRLERLSDSWAMAVYRAVFNKDVNLGLTDELTETHRYMKRLPVEPPKYINFDFWKDNLYETFFAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HV07</accession>
    <name>A0A1E3HV07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_07834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000044">
        <property type="protein sequence ID" value="ODN80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028183.1">
        <property type="nucleotide sequence ID" value="XM_019179816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HV07"/>
    <dbReference type="GeneID" id="30197045"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000501">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.172, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="14">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="465" mass="52302" checksum="2567BD5A08D9F01C" modified="2017-01-18" version="1">MSSSDVRSILNLPQAGSSSHHPPAPKKLPQPKKPDGISRELYALIGDNAPSLADAQASIAAVKYREKPAFKSKKVHWEWTPFTPAARQEEGNLKLGHWARVTDSDPEASVEYFGKFNNHGPSSMEYSQYEYDQHLIDPNWTPHETAYLFELLKEYDLRFIVAADRYAYMGPTGMGPEKKRSVEDMKERYYFICKRLVETRTASDPHAQNLLARQYEFDKAREIKRKQYASELFHLTAAEISEEEALYVEIKRMEQNERRFRADRDDLMRSVMGLDSGLVNVDQATIEGVFGADKNKKKRKADDDYLAPSPAPTPKRTPNAAFDNAHCIYHVPTPAEPQGSSYLSTKHPAHLPVYLRSSKLPLPKPTAAIRVTELLAELGVNATKLVMPTRQNLEVLEGLLGAGAALVEMKRQVDRVEQELRTVRAQKEGLLPMATPGVEPSQQSRADSVVSTDTTTTTNRQSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY78</accession>
    <name>A0A1E3HY78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028254.1">
        <property type="nucleotide sequence ID" value="XM_019179773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY78"/>
    <dbReference type="GeneID" id="30197000"/>
    <dbReference type="OrthoDB" id="2575682at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1261" mass="132222" checksum="8B7BD700640B60EB" modified="2017-01-18" version="1">MPLIKKRQPQDGASFFHFDLASLRPKSSRTATPSPNPSPAPTPTSPAHSFSPFSNNATSKASRGSKGHKSLNGMPSIQHVMDAYDIPTHPAPSAAELYKEREGRSRRGTMKLPVMMPPPSGSSYGREGRKRDSWEMEWEARGGVGGGSSTQPSTPDVPSFHGSRQRTQSMKVPPVRPPPLPPVPPGAAWAPPVAADARSGWEGEDDALVMLEKLRGRVEGDGWGYGSKNAGGTAKRHTYTTPHGPLPPPPNTAPLTRKKPRPPPPSQPRPSLESIYSRHRPETQAASYRLTGRHIPPAPAPRGLPPPPPGAHVDTKSSVVGTRYSSASERAPPIPRRSSARPSYPSSKPDRGPGGPAPAYLGDRSYSSFPANTSSISLLDPSQPPPEYPSSFNTTPRQNTLSTNTLKPRGLTVQDMFRPRSSTSSSGTPSVSAGAGGRVREWVKVDRRMESDDEREGKMEVINVPAENVPRSLTGIPLPGRGASASISPKSGTMGLPSEWSGSTRIKTGPRDEHSMGFSALDEHYPSQSLAKAQSSTSPPPPSAMHTRQTKPRANTSSSSFSSHSASFSLSPSASGGPPPTTPRHIPRKASSSARSVSSSNSSTSVVSGAVAAPGSRGGQVSGMDAVGGLPDFSALGSVMKGLRGRLGQKKGGEKVASSPRSPPGGATLYSPPNSQQSSRTSLPSPYPQVHSQIQVDSQEGIARPWTDRLAPAPLSPVKQQLQHQHQEGQVEDVYIIPPSERSKIGEEGRSRSGRRKSGRMEKMFGRGSSASTPVSAPVSGGRPDAQTPADREKEGYESTSTTMAPGTGKGTKEEYRTSASVSVAGSDSTSECSLFFIPKPSSSSEAQGQGAKLQGVKEEYRSEKEANAAKHQSLHLAQEQRARTMLASLASPTTTSNNASPNAAPHPPSSFSPVNASAHTDSLGLNGLVRPTALTGHTTQEWEEDEWQIHAREQEERERKGLMPPPRPRTRGQGSISEERAPAFGAGSLPQSSAQEFLRSPPITPLPSQSSHPQAHPALPITPATTPTPISSAAPDKRKKEGGEEKRLRRKPSGVGRAVGLEVELGGASEGGKGSVKRKGSASASGGPYPTPTTPNPLAAFKSAISTSPSPSIPTTIPKAAPAPAPAPAPAPSPSPAPAPTTKPLPADPTPRPSSPSVISTTSTSTPTSGSGSSADFIKEREEKERQRRALMDMWLDAKPIRGQKGSGSGSGTAPSAFGAGRKVSGGARPGTSTGQTSGEKQSLGCFRRASLDGRRLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I3A9</accession>
    <name>A0A1E3I3A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000041">
        <property type="protein sequence ID" value="ODN82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028286.1">
        <property type="nucleotide sequence ID" value="XM_019179739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I3A9"/>
    <dbReference type="GeneID" id="30196962"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26378" checksum="210EE011A81F2AA4" modified="2017-01-18" version="1">MSPRAAHTPPRTLPEFLRRLSQLLAIVLGVSSAGSAIWSLFILPLLHASFSARKALVDQQSDRAINIARALSRIRSLTIYGQPSPADTPAEGGEEKQVDGPLEKMSDASLQEIHSSAASESSLTRDSGATPGQAVFPLSNLSTLSSSLSRLTSALESTSTTRTSLISNLESYTSHLHRQLFAARPVGSKGFGGYAVGMGSLDAHLRNEGEVESRGEEWDAVRKDIRAIKGMLLNRRTSTPVAGANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I5H5</accession>
    <name>A0A1E3I5H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AWGH01000038">
        <property type="protein sequence ID" value="ODN83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028399.1">
        <property type="nucleotide sequence ID" value="XM_019179631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I5H5"/>
    <dbReference type="GeneID" id="30196853"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21535" checksum="7E3F7E350E7C0FA3" modified="2017-01-18" version="1">MQLYELTESPESGYVKGVVRRFAQSSNDHRGTPELPGRVVTVVEAPVWHRLEGKETEDGQVLADDYVWGVAYRIDPEKEPKVQAYMGEYILNGYTCHHVPVYGLSADGKQEHIVVQDSTIWIGKPDDPAFVGYEPLDKIAQTIAVRSGPSGPNKEYLYKLAESVKNLYPHVRDDYLFALENKVRTLDLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9D0</accession>
    <name>A0A1E3I9D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028421.1">
        <property type="nucleotide sequence ID" value="XM_019179564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9D0"/>
    <dbReference type="GeneID" id="30196783"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="265" mass="28588" checksum="74F7AED69DD65209" modified="2017-01-18" version="1">MATPAADIRLYKNRQSPVAHVAFVHPGDGKGRPETLMNIPLIIVAVCDEDTDEDDKDSYAVYLHTHKHSGLVEAVSQGNGTLTASTIMIDGMVLSPTAHDHTFNYRSATLHLHNPTILPSPSSPDTPQHEEKRHALAVVTDTCTGYDRTSAVGQPMDANVSGTTVIKCRIAAISCKQRYGAFNGGQEPVLEFEEGSGGEGEKAFQGVIPCWTQFGSLVGFGKDREQVQAVFDQRSTQARAFSHSAAWADESAVIEDLGKKRPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB95</accession>
    <name>A0A1E3IB95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000034">
        <property type="protein sequence ID" value="ODN85890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028595.1">
        <property type="nucleotide sequence ID" value="XM_019179454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB95"/>
    <dbReference type="GeneID" id="30196668"/>
    <dbReference type="OrthoDB" id="2578353at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30807" checksum="4581E7A98AB90C1F" modified="2017-01-18" version="1">MTSKRAPPPPSIWHGVIESTLNHGRLPSRPVRNPPTPPGPPPPLLQDAPMRSPSRSRSPYSRSPSRSRSPYSRSPLRSRSPYSRSPLRSRSPYSRSPSRSRSRYPSRSASPSPSPPNHSPLPPLPGPTHTRYFPASSPGDEHLGPHFRRYGDRLVYETSLVLANVYWISPGCWGYDFIHPDEPWLAPLRRNENNLFPWQKVLAQDFWRQSPPDWSFAAPDALAALDHTTWSPTTAGLHPNHLDATSLVFGPGRPLTARHVRGGRPPPNKRQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE10</accession>
    <name>A0A1E3IE10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_07161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028791.1">
        <property type="nucleotide sequence ID" value="XM_019179174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE10"/>
    <dbReference type="GeneID" id="30196372"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="369"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="596" mass="65793" checksum="B348FB736560D0A9" modified="2017-01-18" version="1">MSTVTFENIYHGDSSQLGKLRFNPVGFGWKAYQSEDNNPETYTGTDIRHATFFRVARSYQLRLTMRNAERPRITYDGFPHGELDKLKRTLQEYFDINIETKDISLKGWNWGEAQVQGNDLAFQVQGKTAFDIPLSQVANSNIAGKNEVALEFNPSSNYSFDAKDLSKRPPDELVEMRFYIPGKSMKKVGSDAGSGGEETDLDDEGNEVSAADAFHNLVKDKADIGAVVGETIVVFEDCLILTPRGRFSIEVYQDSLRLVGKSTDHRVPFTSIHRIFLLPKLDDLHIQLVIGLDPPIRQGATRYPFLVVQWPKDEVVNAELNLTDEQSAAYPDLEKSYDATTFQVVSRVLKSLTGKKVTPPGSMRNAQGLNGIRANVKATQGELYFLEKGLIFISKQPILLDFSKVESISFSRVGGGVASARTFDMRVVSKTGTADHVFSAINKQEVGSISAFLQGKNIRLKNEMEEATIDIEGGFSDDDEEMDSASEDERPSKANKANKASKEKAKAVKNSAPADDDDDESEDEDFAGDSSSDGGSTSGSDDDDDDSGMASDASDPMMEELRKKQQAKKPKKKAEESGSDSEKPAKKKAKKNEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE30</accession>
    <name>A0A1E3IE30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028811.1">
        <property type="nucleotide sequence ID" value="XM_019179194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE30"/>
    <dbReference type="GeneID" id="30196392"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="123" mass="13617" checksum="615157EC5856E1DC" modified="2017-01-18" version="1">MSTQPLLQRTAKKRIALPVRVEPKVFFANERTFLSWLHFAVVLGGLAVGLLNFGDKVGKISAAMYTIIAMGVMLYALVVYQMRARAIRLRTGAPYDDRLGPTMLCVALLAAIVTNFILKAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IEW9</accession>
    <name>A0A1E3IEW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor eIF-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_07111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028883.1">
        <property type="nucleotide sequence ID" value="XM_019179125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IEW9"/>
    <dbReference type="GeneID" id="30196322"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="159" mass="18183" checksum="853CF265D3DC455D" modified="2017-01-18" version="1">MPKNKGKGGKNNRRGKKDDGENKRELIFKEDGQEYAQVVKMLGNGRLDAKCQDGENRLAQIRGQMRKKVWIVVGDIVLISLREFQDERADVIHRYTPDEARNLKTYGELKDFQLVENQEAGGESDEEGGIEFEEADIDDISMPQHSFHEKKPAFVGLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFA0</accession>
    <name>A0A1E3IFA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028879.1">
        <property type="nucleotide sequence ID" value="XM_019179121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFA0"/>
    <dbReference type="GeneID" id="30196318"/>
    <dbReference type="OrthoDB" id="10427807at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="144" mass="16167" checksum="1FB73AC28B2C488B" modified="2017-01-18" version="1">MSSAAKTATTSTFSRRAPVAPSLPTIPTITSISTLSTLPNTYRTKLPPPSRGHTITHPVMPPKPTTERYKSVQASYQSKTKTETKNAVRTTEKKKRVNATQAPPQARPPLPPPSPKKEERPKGDRARELSYRYTYRKRQVTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL8</accession>
    <name>A0A1E3IFL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028953.1">
        <property type="nucleotide sequence ID" value="XM_019179035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL8"/>
    <dbReference type="GeneID" id="30196228"/>
    <dbReference type="OrthoDB" id="2577115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="19834" checksum="5BE67240B29DBCDD" modified="2017-01-18" version="1">MSLDLSTFPPNSRHGNFSNAYTGHMCYCPMHLDLTAPKSSVGEWVGSGKPLFPGDPVQLVTFEDGKSTFLCAGCAVSAVGCSTGDPDENEWAVGTVTRNTMETAGIYEDYKNTFKKAVSVQSGAMDPDGEICSIWVEATPFKIDRDTMTDPDTVSRKYAEFAQLQTVDESKASLADEWVDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGL7</accession>
    <name>A0A1E3IGL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">L198_06974</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029087.1">
        <property type="nucleotide sequence ID" value="XM_019178993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30196185"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000207">
        <property type="entry name" value="Glutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000124">
        <property type="entry name" value="Glutamate synthase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="2"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="904"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1146"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1152"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1157"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ODN87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="2136" mass="234671" checksum="B2E237278D7E0D82" modified="2017-01-18" version="1">MCGVGFLCSVKGEPAHKIVSDARHILCNMTHRGATGADARDGDGAGVMTGIPHDFFVREASYYFEAKLPAPGHYAVGNLFFCKDAFEDQKAIVEEVAKSLGLRVLGWREVPTDNTILGPAAKSKEPKILQPFVVLEDHYGAGQDSQEGAFDERKFERQLYILRKQATHKIPLKDGFYVCSLTTSNIVYKGQLSPVQVYNYYHDLNHALYASHFALVHSRFSTNTFPSWDRAQPMRWAAHNGEINTVRGNKNWMRAREGNLKSDRFGDDLELLYPIVESGGSDSAAFDNVLELLVVNGVLTLPEAVMMLIPEAWQNNDLMEPEKKAFYSWAGSLMEPWDGPALFTFSDGRYCGANLDRNGLRPCRWVLTSDGIMVCASEVGTISIEPEKIVQKGRLKPGRMLLVDTKEGRIVDDKELKMKTARRQPFASWVESQMLRLPDVLRRVERFETIGVQLDDSPLSTDPKLLAFGYTIEQLNMLMLPMVQEGHEALGSMGNDAALACMSTTPRTVYDYFRQLFAQVTNPPIDPIREAIVMSLETTVGNEGNLLEINPKQLHRLHLKSPVLTIQEMNAVKHMKVANSGWPSITIDITFDKREGLPGYRNALERVRQESINAVNAGFTSLILSDRATGPDRVPLSAILAVGGVHHYLTKERQRSKVALMVETGEAREVHHMCVLIGYGADAVCPWLIMEMIHKVDREGLAKDSQTAEKLVGNYQKATDEGILKVLSKMGVSTLASYKGAQLFEILGLHEEIVSECFVGTASRVQGATYELLAMDAFEFHERAWPSRDAIVVPGMPESGEYHYRQGSDMRVNDPVSVAQLQDAVRQKNQSAYDTYSKNSHEAIKRGTLRGLLDFKVEDATPVPIEQVEPWNEIVRRCVTGAMSYGSISMEAHTTLALAMNRLGGKSNTGEGGEDAERSLPIPGPGADLDGQPFTHAMELKPVWDSRRSAIKQVASGRFGVTSNYLADSDELQIKMAQGAKPGEGGELPGHKVSASIGRTRHSTAGVTLVSPPPHHDIYSIEDLKQLIYDLKAANPRARVSVKLVSEVGVGIVASGVAKAKADHITISGHDGGTGAAKWTSIKYAGLPWELGLAETHQTLVMNNLRGRVTVQTDGQIRTGRDIAIATLLGAEEWGFATTPLIAMGCIMMKACHKNTCPVGIATQDPALRAKFAGQPEQVINFFYYVIEELRQIMAKLGFRTINEMIGRADMLKVDESLRTPKTAHLDLSPILQPAHLLRSDVATYRVRSQDHKLYIRLDNKFIDEAEPALQKGLPVTIDCDVVNTDRALGTTLSYHVSKKYGEEGLPRDTIHINMKGSAGQSLGAFMAPGITVELEGDANDYVGKGLSGGRLVVYPPKASPFKAEENIIIGNVCFFGATSGQAFVRGIAAERFAVRNSGATLVVEGTGDHGCEYMTGGRVVVLGLTGRNFAAGMSGGIAYVLDMAHSFAPKVNMGSVELGPVSDPHEVAELRSLIEEHRHYTGSEIADRVLKNFHHVLPMFVRVMPLDYKRVLEQEAERVANEKKRQSIIDLIPSQTASQVDLVATGFDPVLPRDANALTISTPNLLSPIGSPKAKPQEPSIVDVEDAMIDETATKEKLAKVDKVRGFMKYKRLNEAYRPPRKRVKDWKEISARLKPQELKVQSARCMDCGIPFCQSDTGCPIANVIPKWNTMIFEDRWQDALNRLLKTNNFPEFTGRVCPAPCESACVLGINEAPVGIKSIECAIIDKGFELGWMTPNPPEHRTGKRVAIIGSGPAGLTAADQLNKAGHIITVYERQDRVGGLLMYGIPNMKLDKGVVQRRVDLMAAEGVNFITSAHVGVDERYDPLAIKAENDAVVVATGATWPRDLKLPHREVDGIHFAMDFLTPNTKVKAFGDDAPGFISAEGKDVIVIGGGDTGNDCIGTSMRHGAKSIVNFELLPEPPKSRAPDNPWPMFNRSFRTDYGHSEVQAHFGHDPRRYCMATKKFVLDDEGKLKGLDTVKVEWTKMNGQWKMEEVAGSEEFYPAQLVLLALGFLGPQQECLKALGVDTDPRTNIKTAPNSYVTNVPGVFAAGDCHRGQSLVVWGIREGRQAAADVDSFLMGHTHLAWQGGIEKRQYVVPPVTKPLHGLDEKIISDFETSSQGVDLESLSVAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IH36</accession>
    <name>A0A1E3IH36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029078.1">
        <property type="nucleotide sequence ID" value="XM_019178984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IH36"/>
    <dbReference type="GeneID" id="30196176"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN87735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="214" mass="24084" checksum="A88B229CEB79F351" modified="2017-01-18" version="1">MSAQASSSQSVTTRPTAHGQGSSAPPTSLRPIKSASGFEFPAMWSFPPFFTLQPNPQTLAHQLLLWRNLFLEWARHERVFEVNVDSAGKDVLGVFANKGIGRRLLPPSVKTLMGELVKNGEAAPDPPKQDTHYLIYWRKPEEWGDIIYHWVMENGLNASIMTFWEITDGDLSETTEFRQLPVSILRKALESLVKRNRAQIFEGKGEAGEGVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHN6</accession>
    <name>A0A1E3IHN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029177.1">
        <property type="nucleotide sequence ID" value="XM_019178900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHN6"/>
    <dbReference type="GeneID" id="30196084"/>
    <dbReference type="OrthoDB" id="10587518at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129793" evidence="2">
        <location>
            <begin position="21"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="546" mass="54697" checksum="02B542589B112826" modified="2017-01-18" version="1">MLLSLKKLVFILPLLLSISAETPASTFVPDDATSVVSSASIASSTSESVAITSAESISENSSTLEDKSTAIEATPTSSSYTAETISSSEEAVPSTTSDTAEESITSSAYVPSSSITPTSSTEKGSIPTYQSSISSSSTEATTTSEIEEDCPEESETASTTESSAATSAVSSIEEDCPEETDVSPDTTAAATSTTSEQPSLTSSATTETSSDAGQCQCPCACTASGAQSSSAIGGNLGAVPPSSTSGSDTAQASGDSASVVSSSEAVPTTISGTASDSSATQTAATISGQEGDATDSAASETDLAASSTAAGESGAADSSGSVTSGAGEASSTSLASGAGETGEAAMATSSSELPVSSGSTTASGAASSGSANATTTGNATTAADASTPTNPGKYGTLTYYMKGNVMIFDGNSEVGLAISPDEGEDSSDYSIRLTDNQAYSSVWSFTSWTTTSDGKYGLDVEGSSANRNITCLVTFNTGDHSNLASVTIQDSDPWVTEDDTGHTLAMYCDGDYQDNDPDDQEKKKKRRRSMGSASHLGHHSRRGDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IL12</accession>
    <name>A0A1E3IL12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,6-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029493.1">
        <property type="nucleotide sequence ID" value="XM_019178586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IL12"/>
    <dbReference type="GeneID" id="30195743"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="61178" checksum="6BAF0ABCD1976AB7" modified="2017-01-18" version="1">MARLFTPRSLLRFNTPAKLLLVLFALVFYLSFSFSTSHPPSIFTDSETRKQIRNASLSEIVNLYEQVRHGALRAKGFNGTVCAESIKAPKTLPDGTSNLDPDVEVYTGRLRGFIDNYLQQAPAHIHIAARNTLKSLVKRESPTYRDGSFPAKVWATHPAGIKGVQLGFELWGKILPFPLPPSLANQISVDKDVDFLQPARNGQDWDVEVPDDDGLDRIMSEWTGQKLQRGIPGEGKWSELWGGLEMGVLRADVFRYTSMLVAGGVYSDSDTMPISHPFLWGLHAPSIINPDLELLAELIVNHGGPKFPPNTRPPRIDSRSLPQHNSSYTPPYPGIERRSPVYVSIPNPSTILNPRISMVIAIEWDNKIGRTLGMWRQWTWSRFTESSKYPRNIEFVQNLLVAKPFHPIMLDTVATIAQLVESGEAKSLRPASHLLELTGPGPFTDAVLRYLLVQYGVTPKNLRALRGPVRIGDILILQEEAWHAPFEAIKQLWEYVESLHLKLGTNRHGRFSPWLFGLGWKDWKSGGVKVAYHGLTGIWKDKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IM91</accession>
    <name>A0A1E3IM91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shr3 amino acid permease chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029629.1">
        <property type="nucleotide sequence ID" value="XM_019178473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IM91"/>
    <dbReference type="GeneID" id="30195626"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20829" checksum="43DF93167E475662" modified="2017-01-18" version="1">MAFLQSVVLASCSFILGIVFVSQVVDIPLLYMPVTETAIENGYKFYELWWEAPGAVKALFNVALALPLVALLVKLHKWNESAMFFDGSCVAMHLATVILYLTVHLTSLRTFLPESTVASSYSVLPTPAPREFPPTNDEKIEALRVLAAANALVGLLTVGIIGMQIGQEYARRVEEKEQREVDEEKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMB8</accession>
    <name>A0A1E3IMB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029577.1">
        <property type="nucleotide sequence ID" value="XM_019178421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IMB8"/>
    <dbReference type="GeneID" id="30195568"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="228"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="625" mass="67901" checksum="D22DA3006B37A18F" modified="2017-01-18" version="1">MSYSQPPKIPQDRTETSGVGTGHKDDSTSRHGVALSSSNATLCHPGEHNEKASPDVSPKPGPSQLPTSHPSTNHHLPHRAPQPPPVPPIGVVSVFDPASLGGGGPLKRIETQRSERYAEEEREREAREEAGETGKGGILQRWSTVSRRRPVVVLPPHSQRHSEDESSPIEGEKVARRLSTAFSFKTPVATPAPREKDDDYRFPSENDTEPQTSEEEAEEHEYPDGGYGWVVLGACCCLSGCTLGWGMCYGVFQEYYLSNVYLDADTSVLSLAGTLCAFMMNATSFFSGRYGDRFGFKRVLYCSAIVSWLGLFLAGWSTKLWQTILTQGLLTGIGQGLALPLFMSLPSQWFYRRRGLSSGIAIGGAGLGGGTATLVCRQLLTTVGHKKTLWIMACINLFFMTVSTMLVRTRPTSLEGRATGKGPWVDWRVVKTSSFWSLVIGLVVACTGYAMPYNFTSQWTRLHFPELRPILLALPVTLMGFTVCIGRAMIGLVADYLGPMNTFILCFLLSGAVQLCLWLTASSFASILVFAVAFGLVAPGYMGIIPQIIVQLFGADNLATNVGILLLFNGPGNLISGPIGGALYDSSGRTTFKYMIITSGCLQLAGGLICCWARFKASHKVFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INS8</accession>
    <name>A0A1E3INS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_06260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029764.1">
        <property type="nucleotide sequence ID" value="XM_019178326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INS8"/>
    <dbReference type="GeneID" id="30195472"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="150"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="361"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN90242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="70121" checksum="58297A488283BC61" modified="2017-01-18" version="1">MYGNVYAGIRSSDRKSDMVDKLKSAFYGIKSRNDLQTYADVRVRCEAYAFGYTTESLNAALAQPTAVPPASGAPVNGAPPPAAGPSTAAAGSTGSAGFGVQRWQPQTATGGGSNGAAYPASSAPALPERVPPRTALMNAYREAAGPAAINHVPRGPILLEWKTSPMWKPVQAITNMEQLPDITAHESHTNRKERVTRFVLPNDVIAKLNMSHTSPTTTPHYSLRLFCASSDHYRPLNARTNPYGTNKDIPIEYPSLPDVYVDGVGLPFKEKGLRGKAGSAPPFDLEKAPARRGYMPGRMISVAFGHKGPTTGKNKSISKKFFYQLVLAEITTKEELLTRLGNLQPTNAGDSLDQLRRQQDEDDDIVAGTASLSLKDPLSYMRISRPVRSKKCSHLQCFEAQWWVESNATHPQWLCPHCSKELFFDDLIIDGYVSSILKAVPDDYDDVILEPSGEWHTEDNKYASEVWRAAHPPPAPPAPAIPSVPPPSGPSSSTPGLETKPSLTQLNGNDSSNGEGAKRKVVEILDSDDEDSLRGKSSAAPSSRVSLSIPPVGARTGLNTPIIDLTLSDSEDEGPPPPPRAPAPATANPVTAQVSRPHTSMGTSASDMDGENAFWRGNVNDGQGAGINGGSSSLPASSTQSTPAAGAGRMPQMGTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ49</accession>
    <name>A0A1E3IQ49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029832.1">
        <property type="nucleotide sequence ID" value="XM_019178113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ49"/>
    <dbReference type="GeneID" id="30195258"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN90730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24617" checksum="32E7784C43A01316" modified="2017-01-18" version="1">MTLDTHTPVSPDTRGPQATPPDLPGKEESDSWAVHFEPGKSINPKNWGVGHRWFLTVVAGVLVFNSTLASSAPTGIVDGMIDYFGFSQEVCTLGWTSYPSIHWMIPVLAGAFIGIGTLGMFVSLFNYIIDVYLWSAASALVAVTIVRSHFGAAFSLFATQMYEKLGTQWASTLLGFLNLLMVPIPVVLMRYGHLLRAQSKFSPNRAGIVDEGGKCRRSGCEMTIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQB0</accession>
    <name>A0A1E3IQB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029874.1">
        <property type="nucleotide sequence ID" value="XM_019178155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQB0"/>
    <dbReference type="GeneID" id="30195301"/>
    <dbReference type="OrthoDB" id="2574330at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="213" mass="21680" checksum="076032FEB708CC50" modified="2017-01-18" version="1">MGFFDFLPCCGPRPGKSSSPLSRETTTLLPPSGPGREGSFLTASDPGLSLTLTLSGGAASGGGGGVYGATGGERLTEEQLKKIQAIRESTQGYMLPVQSMPPRSHLIMSRTSTAHNHPSSLSSSSPSPSPSSSRPSSRPSSPAALSSQTVRSPEASPYQPTGSLPGSPEGGEGEKGDDVVRKQLFMGNTPMGRGGRKPGGGAKAKAKKGKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQS2</accession>
    <name>A0A1E3IQS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029877.1">
        <property type="nucleotide sequence ID" value="XM_019178158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQS2"/>
    <dbReference type="GeneID" id="30195304"/>
    <dbReference type="OrthoDB" id="10515861at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN90775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="373" mass="40053" checksum="C4201972A5B543D4" modified="2017-01-18" version="1">MAVPPPPAPAIDPYSLLRPTPLAAKRPLPAPPPVSHEEKKKPAVIRRRSSLKFLPMPVTWDEKIPAATHLSPPNTPPAPAPRQNKLQKKPPGNHVFFLEDVSRIPLTPEGHGHEAGGYTYQGEGYKKARVEGGRKEGRGVKKKRSFGLCGPCGPRPMMGEHEREYHYLEDGQGQGGMADVVPASGVSGVKEDPSRPLPSPPSSKTKYPTTPMPLSPISNASSSSSYQHDEPPSPVVSEAWKHTSYFPEYTPLLPVLKAEAEAKAAKEAEEKAATAPPAPPIPPPPLPPPPVIPPPPPEIPFASYPYPYPYPPYAAPPAENGPPMLPPWTAWQGEGGQKAEWTSAQRYYPAGGWNTEGNGGWHSWAGGYGGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IRV7</accession>
    <name>A0A1E3IRV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pim1 protein + RNA transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029966.1">
        <property type="nucleotide sequence ID" value="XM_019177927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IRV7"/>
    <dbReference type="GeneID" id="30195063"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="101"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="294"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN91340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="601" mass="65008" checksum="40CDB9511C07DD8B" modified="2017-01-18" version="1">MPPRRSTSRASSKPPSKATSRAASAKPVSKAAPKAASKLDKVPEASVPVVNGNKKRRKVSDAHEPPAKKGRVSSAAGSKIKKGEVNQIPAIPAVSEPHNALFVWGTGDQGQFGLGPDLLEEIARPKIHTWLEEQSEEGKLSRDGKPGGGLESVDCGGMHTLAIDEGGRVRSWGINDNAALGRITVDVPDPSDPSKAIENEELETYPFVVETLEKEGFRAVQVAAGDSISVAISDKGELRAWGSFRSNDGVLGFDGVPGHPKFQFTPISLPALAKVQITQVSCGADHVLAVTTAGHVYVWGKGEENQLGRRIISRRRINGLEPERLGLRNIIHVATGIYHSFALDKDGVVYGWGLNTFKQTGVTDGDDMVITPTPVDALRPENHNGSKVIQIEGGEHHSLFLFDNGEVWGCGRCDANELGLPSDHPAQEGIKERRQELQEYREEKVTQRQKKLDEILQKGDKVDEDDKAKAEQELEEAKVALKLPPSGEYVPEPVRIAFPPIPESYEVVPEFPAWKDSKSEDNPIISISAGTRHNLAVSKSGHLYAWGLGNQGQLGLGSEEDAEVPSLVRSKLLRPYKSLTPSAGGQHCVVLGTKKPEDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS47</accession>
    <name>A0A1E3IS47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030018.1">
        <property type="nucleotide sequence ID" value="XM_019177979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS47"/>
    <dbReference type="GeneID" id="30195118"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="596" mass="67455" checksum="4373ED815B8E9669" modified="2017-01-18" version="1">MDQIASQQAAAGGRKLILEERRLGWRASEAWMGAQSKGRASNSLLSMTPRMLIVFSYEKEDEPPKESKPAFVPRQHLKKEQDSRYKDRAALRREGVNDEFKSVEKLLEDFEARKEHATAEELAEIEKQRVYLGGDAEHSVLVKGLDYALLAARRAELAREEGEEMDDELEAFQEQMKDKKPAKSKAGKGKEEEKPQEEELGKGFKSIAQKKAEAEAAAAAPGDKKKKKKKKKVKTDPASASVPDTTATPSSIPSKKATVEEPIKSPPKAPTPPPPESDDDDDIFGDAGEYDLAAAAGPVGSDSDSEDEKMDAEDGEISRGRSRSRSFSRDRSYSRDRSLSRNRGYGRGLGPRSSGSRHSRSRSRSRERSRYRSRSSSRDYQRRYSRSPSYDRYDRRRPPSPPRRRYRSPSYSRSRSPYGGDYKRRRMSYSRSPPRRRFDSRSRSPRRRYSPSPRPRGRSYSYSRSPSPPPRRARSRTRSLSPLLNAPILDRSRSPTPSSDEDGPSTRLQPLASSAIPSLKSFLAADEADAKADEKRANKAKWRAYQGMPMQEGAEEDTAAAKQKTMNEKQKSNREYQLLMNKMKKDEEREGKESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW60</accession>
    <name>A0A1E3IW60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030280.1">
        <property type="nucleotide sequence ID" value="XM_019177896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW60"/>
    <dbReference type="GeneID" id="30195031"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130002" evidence="2">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="334" mass="35005" checksum="122C2471D138C2EA" modified="2017-01-18" version="1">MLLPALISLSLLPAIYAQQSIPRVLVYTATAGFRHDSIPTAIEVLGDNADKYGVQFVFSEDKGQFTNDTLSGFDGVMFVSNSDDVLDDSGQSALQTFFQSGGVYAGVHAASACLFNDTNYEQAVGAFFDYHPTIQSATFERLNTTHPSVADAPDQWTFEEEVYHFRSDPRDNGAVVLLTVNETSYVNNGSSTGDYPSMGDPHPIAWYIESPLSALPLAQSASKAGRSFYTSLGHLNSTWQDETFIGHVMEGLKWALDGASTKAYGVGIVGNGTASATNASSSSSATGSSSASGAASSSSATASESSGAEKFHLTGASSIVLGTSGLTLGVSMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IWG9</accession>
    <name>A0A1E3IWG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030402.1">
        <property type="nucleotide sequence ID" value="XM_019177651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IWG9"/>
    <dbReference type="GeneID" id="30194783"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129991" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7634" checksum="13EC5C481032D595" modified="2017-01-18" version="1">MALGRLVHFAFDALAVSTILAGVKKTTGFAPATDLIPDSSLKSVTDSYLGVGHTIFDIVAGQSVMSQYFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXV5</accession>
    <name>A0A1E3IXV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrokaempferol 4-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_05530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030363.1">
        <property type="nucleotide sequence ID" value="XM_019177612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXV5"/>
    <dbReference type="GeneID" id="30194743"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN92736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="347" mass="37610" checksum="61E38434B38B05AD" modified="2017-01-18" version="1">MPAVKPGSLVLVTGASGYIAAHTVDILLQRGFNVRGTVRSQSKGEYLSNLFKNAPAKFEYHIVGDIAQDGAFDDAVKGVDAVAHMASPFHLDAVEPAELFEPAEKGTLGVLKSLRKFNPDCKRVVITSSVATIVNSDLPQPHTFTEAYWNPVSLKVCAEKGRDADGVNKYRGSKILAEKAFWKFIEDEKPSFDGVAINPPLVLGPIIHECATPESLNTSVASFYDWMIGKKTQDDLPAAGGNYVDVRDCAIGHVQALVVEEAAGERFITGNGASSGNDYVLSIAKAYPDIKGVPKGNPDPAYRQKLRDDYSYFDGSKATKVLGIQYRPQDETFGDMAKSLRERFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXW7</accession>
    <name>A0A1E3IXW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="12" type="ORF">L198_05325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030565.1">
        <property type="nucleotide sequence ID" value="XM_019177412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXW7"/>
    <dbReference type="GeneID" id="30194538"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="568"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="957"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="640"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="647"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN93460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118176" checksum="CA6B2A951C8CDFED" modified="2017-01-18" version="1">MRKQLDPRIPALINNGVKSNHRSFFVMVGDKGRDQVVNLHFLLSQARVSSRPNVLWCYKKELGFTSHRKKREAKIKRDVKRGIREANDQDPFELFVTVTDIRYTYYKDSAKVLGQTFGMLVLQDYEAITPNLLARTIETVEGGGIVVLLLKTMTSLKQLYAMSMDVHSRYRTDAHQFVQPRFNERFILSLGNCADCLVLDDELNVLPLSKGKDIQIGKAGEEDDRGRKRKAEELKEMKESLEGVDIVGSLSKLAKTVDQAKALLTFVEAISEKTLSSTVALTAARGRGKSAALGLAIGAALAHDYSNIFVTSPDPENLKTLFEFVFKALDALGYEEHIDYDVVQSTNPDFKKAIVRVNIFRGHRQTIQYISPEDHHVLGQAELVIIDEAAAIPLPLVRKLIGPYLVFMASTINGYEGTGRSLSIKLIQQLREQTRPTITKDNDTTTGAGNGGSSKSASAGPSGAGLARSLREIKLDEPIRYSPGDNVEKWLNNLLCLDASIVSKSIQGCPHPSKCDLYYVGRDTLFSYHPASEVFLQRMMALYVASHYKNSPNDLQMLSDAPAHHLFVLLPPIDENDNTLPDPLCVLQVALEGNISRDAILKEMSQSGMRSSGDMIPWIVSQQYQDNDFATLSGARIVRIATHPDYARMGYGSRAIEALTSFYNGELYNFEDATNDSGESFADAAKVGPNASLQNDTIAIRDPTRMPPLLQRLSERKAEPLDYLGVSFGLTRDLMKFWKKAGFTPLYASQKENTLTGEYTFVMLKTLLGAGNGEWLGAFAQDFRQRFMNLLSFESFKKFEASQSLSILESTVPRNSPSPQPKPLTASELSTLLTPFDLKRLESYTDSMVDYHVVLDLVPTIANLFFARRLDVSLAPAQQAILLALGLQRKNVEALETELGLTATQTLALFGKILRKIAKALEDVQKEGIVSELPAESAPRGKQSFVALQQTVEQELADSVPRVNQGAETEEEKQSKKEQRELLDSLDMSEFAVNQGGDWSAAEKQVEKLAEGGNARLSNTVSVKFDKATDAEEKKGGKGKEAVKDGKKKKRDSLGDKGGKKKMRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IXZ6</accession>
    <name>A0A1E3IXZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030595.1">
        <property type="nucleotide sequence ID" value="XM_019177442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IXZ6"/>
    <dbReference type="GeneID" id="30194568"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="193" mass="21026" checksum="E024AA6D14047B90" modified="2017-01-18" version="1">MSSSDELEEMGPITPAMKRFLSAERYAVIGRVLDDRSRWDNKASGKLRDSVDYLLSDLERRYQARNYPVAAVRPDKPSKSIEGLDVLTDPASISTFRLTPADSPQLSIPSLPSTSVSIIIHPVKSLGILQSLFANPANAPHSVWFQPGADDGSIWKWVKEKGLEAKIVGHGACVLRDGDGVLDAIKSDGKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY30</accession>
    <name>A0A1E3IY30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1 6">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1 6"/>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030648.1">
        <property type="nucleotide sequence ID" value="XM_019177495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY30"/>
    <dbReference type="GeneID" id="30194621"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN93543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="20321" checksum="EF3030E7A5A5C596" modified="2017-01-18" version="1">MGLLVDGKPLSWEATELLAEHIWSHGITQFLKIWDRTKGRVCHEFLWGDEIEYMVAALDDKNAAINKFAFRKDIFPPKGSLDSESTADIQEMSLDKIINGDGGAFPGLMGAVEGYLRIVGADEDAMDGISKYLELIKLRAKGGLCERFAHSGHLDLITSRPAYKQDSIVSDEMNYHLIKNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY73</accession>
    <name>A0A1E3IY73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05387</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030627.1">
        <property type="nucleotide sequence ID" value="XM_019177474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY73"/>
    <dbReference type="GeneID" id="30194600"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="126"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN93522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="802" mass="84199" checksum="8E463E405C28E662" modified="2017-01-18" version="1">MSHQISFPAPKSDLTVLLLGAGGREHALAFKLAQSPRVARVVVCPGNGGTALMGGKVENLTLPWGAPPAFASIVEWSQTQNVDLVVPGPEQPLVDGVEGAFKKAGIAVFGPSPAAAMLEGSKSLSKEFMARHNVPTAAFRSFLSNEYSEAAAYINSNPFPSGRAVIKASGLAGGKGVLIPETNEAALAALKSVMVDKEFGDAGDEVVVEEYLTGPEISILAFCDGYTIIPMPAAQDHKRIGEGDTGLNTGGMGAYAPAPIATKEIMDRCVQEALAPTIKGMREEGHPFVGMLFTGFMLTANGPKVLEYNVRFGDPETEALMLLLDDETDLAEVLTACVERRLDSVKLDYKPGFAISVILASGGYPGSYPKGVPIDLGSRPQGVEVFHAGTKLQNTTTLTDGGRVLAVSAYAPTLRAAVDLAYSGVDQIAFEGKTYRRDIAYRALSSVPVEVTPAKGLTYAAAGVDVDAGNDLVDMIKPVVKATKRAGTDSDIGGFGGAFDLAAAGFRDPVLVSGTDGVGTKLRVALDYGKHNTVGIDLVAMSVNDLIVQGAEPLYFLDYYACSKLDVPVAADVITGIAEGCLQAGCALIGGETAEMPGMYHADDYDLAGFAVGAVERNLILPTPDITSGDVLIGLASSGPHSNGFSLIRKILAHDNLSLHSPAPWDKSITVGESLLTPTKVYIKGLLPGIRQSLFKGMSHITGGGFTENIPRVFSTDLGVTLDLTSYKLPAVWKYLMKAGNVEAKEMVRTFNCGVGMVIIVSKEKVEAALASLKEGGEDAWVMGEVKEGKGVEYIGLDKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYB2</accession>
    <name>A0A1E3IYB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030667.1">
        <property type="nucleotide sequence ID" value="XM_019177514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYB2"/>
    <dbReference type="GeneID" id="30194641"/>
    <dbReference type="OrthoDB" id="10294204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN93562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="326" mass="36575" checksum="C8EE798C05332F33" modified="2017-01-18" version="1">MSEATQSQGLDERLPPHAIPGLFHGMSTGSVLGGVGMTDFDNGEPEGWSFQPHPLNDDLTGDDEKRVMGAICDTRVHYHPRRMHLTLHRPIPSASALNRGADAEYTQAIDPEQQAITRIEFVIPSDYPQAEYTVEREEDGSRRVNVISSASPGREPLFTEVTCFHPVRNNRTMETDGPLIRGDDIYVTKEYMEIVSDFPSDKDRMDQIEYESMQGNDVHENGEPVGLWPEFEKPIELVRTDQSGGRTSFSLDASYFPSAKRVTRPTAADNFSYVTIRHKDMDTFAEVQFLVAADASKRAREEEWESRMFTDLSIGTRADEGVVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZS1</accession>
    <name>A0A1E3IZS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030511.1">
        <property type="nucleotide sequence ID" value="XM_019177358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZS1"/>
    <dbReference type="GeneID" id="30194483"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN93406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="563" mass="61366" checksum="9EA43CDB0D991A60" modified="2017-01-18" version="1">MPPSVYTSPRTDPALPRASVFDYLFPRDNTFPFYPAPRTDPRRSAFVDALTGRSLTRAQVGEHALALAGGLKRLGLGAGDVACIFGMNSIEWVNALLGCQALGVVTSPANYAYTPTELLHQLKDSTSKAVLVQPELIPILHEALKLDPALGIPVSRVILICTKQQKPADLQKLKCTEEIREYGEGVDGRHQWKEGDEVNTAYLCYSSGTTGKAKGVETSHHNMTSQIQAVHCSIEKMTEQDVILGILPFSHIYGLTVNIHHALTVDTSVVVLPRFDEYKVTFGVVVPPLILVLLHSANVPKFDISTIRGLQSGAAPLSADLIQAFRTKFPWIGITQGYGLTETTPVAAVMTLDEAKGHQGGTGKLIPTYQARLVDAESGKDVPKGERGELWLRGPSVMKGYWRNAEATKAAFQDGFFKTGDVAVIDEQGYISIVDRVKELVKYKGFQVPPAELEALLLTHSEVMDVAVIGIYSKAQATELPRAYVVPKKGLDSLSPSAREQLSKEIHDWAASKTANHKRLRGGVILIDVIPKSPSGKILRKDLRVLAAKEEEQEVVAGRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IZY5</accession>
    <name>A0A1E3IZY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030571.1">
        <property type="nucleotide sequence ID" value="XM_019177418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IZY5"/>
    <dbReference type="GeneID" id="30194544"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN93466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="337" mass="37526" checksum="768E8DBF9A853193" modified="2017-01-18" version="1">MTEYWVSKKQYWCKFCSIYIRDDAPSRRQHESGLKHQGNKERFIRDLYRGGEKAKKEKAEEAREMARIEAAASAAHAQDTASGYSKASSSTPSSTAAAAPAPKTREKPTDKWSNYSTAAQLGFVDEEDAKKTAYEIELEIKGQAGEAGQWEEVILPPPAPIVEAAEVTIGEKRPREEDEEGEGWKFEHKGKKPVFDPYDDDWDPSSLKSLKVKRKEGASSEDAKVAAEETATEVPRVKYEKEAAEIEERGLKREGWSGKLEWNTVKKETGTSKEVKEEADVREEIAKATPEQAAVPARQETVKSEPEVESSSVSESTVASGGGMFKKRRPPPSNRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J024</accession>
    <name>A0A1E3J024_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030764.1">
        <property type="nucleotide sequence ID" value="XM_019177183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J024"/>
    <dbReference type="GeneID" id="30194300"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="118"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="385" mass="42401" checksum="FF93E52D0E96C834" modified="2017-01-18" version="1">MVPARPPLTSLHDVVLEYITVNAYASTARALFNSNQGSLTGSSEFARLPVDGLGQPGPSNGITKNGAGNGNVQGDHGAEEGMDVDDGNVDDEEAEDEFAHKGEIPASRIVIDKDMLQSIERRREILDHILNGFIERAVETLQNHFPDVLRDVPEEPSWSTYHSDSTANCNGGTRLHVSRSLQWDNQASHDTPVFNTSSDPSHVRLNLQIQQFIESFRQLNPGSSTSSPASSISSLANSQMMNGGGGVTLTHALTSAQGLHAEAKKLKPEVRAVYMQEIKDVGALFAYENVEQSPLGGFVKQERRIRLAEQVNRAILESKGTPVESQLEEYTKRTQAIYALLGEHRVDVQPPWTSADGAAKEHVAEFWKYYGERPFSLQDFLDFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0G4</accession>
    <name>A0A1E3J0G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030833.1">
        <property type="nucleotide sequence ID" value="XM_019177252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0G4"/>
    <dbReference type="GeneID" id="30194371"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="111" mass="12438" checksum="3FBC45264827C548" modified="2017-01-18" version="1">MSSGKKPQGAGDDYVLLESSDGYTFVVSRKIACASSMLKNMLDEDAAFSEATNKACKIQQRGCILLKVIEYLAYKVQYQEFNAEDVQEDFQDRIDPYIALELLTAADYLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0L3</accession>
    <name>A0A1E3J0L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(RC)-binding protein 2/3/4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030889.1">
        <property type="nucleotide sequence ID" value="XM_019177308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0L3"/>
    <dbReference type="GeneID" id="30194430"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="374" mass="39520" checksum="0E2C99D0EE8D92EE" modified="2017-01-18" version="1">MSTNPSRDPSPAPQIPPEASPTAAATAHPKRPASPAHQDQHTDSKRVKTDQGTERLRETRENGKMSDVDMESTQPASESSLPAPSSSKADPGPQQISMRSLIVTQDASIIIGRGGAHVNEIRDKSSARVTVSESIPGNPERILNVSGPLDAVAKAFGLIVRRINDEPFDVPSVPGSRAVTIKFIIPNSRMGSVIGKGGSKIKEIQEASGARLNASEAMLPGSTERVLSVSGVADAVHIAVYYIGTILLEYQEKFPAQGGGSYRQSSGGERERGGERRGPPPAFSPSAPPPPGMQQQQIFIPNAFVGAIIGRAGAKINEIRTQSACQIRVTDPGSTLPDGPPANPEERLVVITGYPDNIQSAITLLYSVSLSCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J192</accession>
    <name>A0A1E3J192_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030939.1">
        <property type="nucleotide sequence ID" value="XM_019176907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J192"/>
    <dbReference type="GeneID" id="30194014"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="371"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="543" mass="56576" checksum="5DBBBD6927D3E320" modified="2017-01-18" version="1">MPSLAPPIPAPAAPPPQPETPEGSDERTVLPSPNGADTDTPTPTPKSPLDSPSPPPSASPHPQQPLEPSPTTAKTAENSEGMPQSKGPAPTAAAASASSSKPSPAPTSTATSKPTPSPSTKPAPPASKQPPNTTAGQKKKRKRKGIAGLLLSFGCLSAEEFEDEPRAPSSSAAGGPSKTKTAAAEAEAGGQKAKVDAATSAGSQPVANGAPDVNNKKDVAPTAGKGHQTEGTGATLVGGDGKDKEVIVPPTEPHTLPEDETAGLTSSAVQPPGSGSSLLGTPSRQVSHRESNPDLGANTAEQTTTSGGYSDISNTDVVDDTTGTGERDDVGGEEYLDYDDEEDRLIEQGGMGIPTDEHGTPCPLLPPLAVKHRGRKCLVLDLDETLLHSSFKQLPAADYIVPVEIESQVHNVYVIKRPGVDRFLTEMAKYYEVVVFTASLSKYADPVLDMLDPTGLVAHRLFRESCYNHKGNYVKDLSQLGRDIHTSIIIDNSPASYIFHPNNAVPVSTWFSDPHDSELTDLVPFLADLAGVDDVRGVLDGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Q4</accession>
    <name>A0A1E3J1Q4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031037.1">
        <property type="nucleotide sequence ID" value="XM_019177005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194115"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="201"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="541"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="620"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="704"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="785"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="862"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="936"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1242"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1317" mass="140598" checksum="7E379C10596AB9FA" modified="2017-01-18" version="1">MAFSAADLQKVRRPFSQASTVMERAGECEGLAVGLRDDERHLELEGAPDPFPTLGAAPTPVAKKVKPATTAAVDTNSEDAFPSLGASSAPKAASKPATSLWASKSSAVKTAAKPMAPGGLGRTGVPSAGSHPFAETFSIPSAELVQGKTTQETVKKVQEQTGAIVESSTQMRTGLKTFHVRAADQKKLNQARRMIEGGLRKPVNISVEVPITVLGTIIGPKGATLKSIIDATGVKIDVPRRDTLPAYSPKDNGSDDDDEENEEPQVPIAVSGSSIGCNDAKERILALFAHKMSQTSTSIKTIPSAFYILFSSKVSELEQGLGESKVSIKVPEPAVWKALEQQGQADIEGRKVSVDSEASIKVKGDREAVKAVVDAIIKEFETVSKGFSLKRVSIPKRQHRFLIGSAASDILAETESIVELPAVDDSSDRVVIRGPQSKLGAAQSLVFEKANAVTVEPVDLAALFRRSTSEPVSHATNVLRYMRSAKIKTIAAAHPKVQIFPAFPSAIENTGDVIIDVVGEDGEEVANVVDEIEALAKTIDPSSVTTVQVDHLAHSLLTGKRSSKISNFEKAHNVTVVFPSASEESSNVLLVYNGPKNANPTGVFEAASNELSEIAKEVADIKTEVLEVDKKFHKYIIGQGGSVLNAIIGEDALVSVKVGVSGSKFPSTTLEDSVTIRGPRTEVDRISKQIAQVVEDGKNDAIVNGYTAQFDIDQKYVPHLVGQAGASINKLRETLDVKVNFDDAAEKEVKKGSKKTTVHCTIVGRKEPVEEAKKRLLAQIEKLEDETTESVTIKRAIQPALIGAGGKYAIRLEEKYGVKLSFPRDAKDTGANPDQVTIRGGKKGVAAVKAELLEAAAFETESRQEASFKVPGKAVAQIVGKGGATINGIKNETGAQIDIEREAGEDGKTTITVRGDKAAISAAKEAVLNVVKELGDEITVELTIDSKYHRSLIGQGGSNLRELISTAGGPSEGYKQAGLVNFPRSGDEATDKVRLRGDSKLVKKIQEELEKQVATLKETVVYGVVVPQAQHATKIGRGGSALQDLQRKTGAVIHFPGSRQYSSIGEIENKEELGDAAETDIVKVIGSKSAIAKATEVLQITSERPQRSDSRQAQGRGTPDLASQNVSIPAKFYHAIAEQANLIRQIRSVGAFLNIPTPAPAKSSPKRPSGDANGEALAAKTARIDLDGEEDVPDVQGEWALEENYQDGGDEELEWAVRAREEDLERAVKILEGALEKAKQATHIGYLTGLPRSAFPRIIGSKGATISRIRLETGADVQVGKEDDLITITGDKESVLQAKDAIVSIVSRPSRESRERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2D1</accession>
    <name>A0A1E3J2D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030807.1">
        <property type="nucleotide sequence ID" value="XM_019177226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2D1"/>
    <dbReference type="GeneID" id="30194345"/>
    <dbReference type="OrthoDB" id="2573841at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="23404" checksum="BAFC268A8B1135A1" modified="2017-01-18" version="1">MSIEIGPLQIAAIVSASIAVILVILVVFYRLYRRRQRGTRTSAHHSPTSSTSSLSPSQHSRSASVRGTSMTTSGLGSATNILTQNARTPLAPIPSTGQTVSVTPSTGGGYHGSSKLRKMMIGAGGGKSLPADKHASAELVVITYEDGLRKLGIDPSCGQPHPHHILYSEYDESEMDNGSQVRAVDSPRAKPGRDRGKAPPPALESTWLPSYYHEPRTVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2Z4</accession>
    <name>A0A1E3J2Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_04605</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031197.1">
        <property type="nucleotide sequence ID" value="XM_019176722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2Z4"/>
    <dbReference type="GeneID" id="30193818"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="507"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="657"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="462"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN95217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="757" mass="71833" checksum="2891CDB3977B47BF" modified="2017-01-18" version="1">MIAGFGGFGQSNNNNSGTTSFGGFGAKPAGQTGSLFGAAPAQPPASGGGLFGSNPAPSTSTGGGLFGSTAPASSTPAAPAAPASGGGLFGGFGQQPAAGSTTPASKPSFGGFGSTTPAAAPPAAPAGGSLFGGASAAGGGGLFGAKPAAPAGGSAPASSGFSFGAKPAESSAPAAPSGGLFGAQPAQTSASAPGAPSGGGLFGGFGAKPAASSAPAAPATGGGLFGAAPSSSTPAPATSAPSGGLFGSTPAPPSGGGLFGAKPAAPAAPTGGLFGAKPAEGSTPSSTPAAPSGGLFGSAPAAAPAPTAGGLFGAKPAAPTPAPAAPPASGGLFSGFGAPKTDAPAPAPAAPKPAGGFSFGAPAAAPSAEKTEAPKPAGGLFGTAPTPAAAEKKDEAPKAPAGGLFAGFGSAPAAGEKKDEAPKPAAPGGLFGGFGGAPKEGEKKDAPAPAAGGLFGSKPVEPAAAPAPASGGLFGAKPASSTPAPAAGTPSVPAPAAGSTTAPASKEKPSESAPNLLRGKTLEDIVESWDRDLEEQVKEFERQAGEVREWDKVLVRNGTQITNLRQNLLQAQQTQAAVDEPLAYFEAQQTQLEQVLDMYEREVQKANSGGAGGEGGGVRVGKMPAEREREKAYTLAEDLNKQLDDISRNLSQMIEQVNTLSSPSSSAPPTSASLASSVAGGRPGTPSQGQAAQAASQAQMPDDPINQLSAILGAHLRALGSIDGGVGRLGEKIGELEGRNSSAGGQKSAFGGRGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J412</accession>
    <name>A0A1E3J412_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-soluble NSF attachment protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031135.1">
        <property type="nucleotide sequence ID" value="XM_019177103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J412"/>
    <dbReference type="GeneID" id="30194217"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000656">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.51, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="288" mass="32259" checksum="41F552843F7EFE38" modified="2017-01-18" version="1">MPSRAEEQIAKAEKKASSSVGWFGNSNTKWEEAGDLFGQAAVSFKIDNKWQESGQAYEREAACRLKLNENNDAMNAFHNAAKSYKKSNPEAAVSALHQAIKLLIESGLFRQAADREKEIANIYAQDGINPAKARDSFIRAGDWYKQEDANATANQCYQQAAEISADLQDYQKSMELYQTVANWSLTSALTKYSVKEYWLRAALCSLAMGDLVTTHKLLTDFAQKDVTFPSTREAKFAKELMDACEEADVERFTGAIYQFDQVTKLDNWKTGVLLRIKKALEEDEGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4D6</accession>
    <name>A0A1E3J4D6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031393.1">
        <property type="nucleotide sequence ID" value="XM_019176465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30193559"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="21"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="424"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="633"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="714"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="902"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1305" mass="144659" checksum="DD1A5C85B6ECBC04" modified="2017-01-18" version="1">MRNIAPLAVAIARLKGSPANLAVDPETAAAYVAVERIDEEGVEIHILRVDGQEVEAIASFNSPVLAPFSKPSYIGETLSLHYLADDRTLIILLAGGDIAILALEGPDGAPAPVEVVGSVDSGIKAAAWSPDDEQIIIITGEDTLMAMTRTFDIIHEEPLCSEDFGQDKFINVGWGSKQTQFHGSLGKSAAKLPSGVAPSLAHGTDHGLPTISFRGDASFFAVSSLDPFPSEPGQEPSARRQIRIYSRDAASGFAPTLSATSESLPGLEPALSWRPSGNLISTLVRYGYSGGGEGREGRWDVAMIERNGLRHGGFELREDRKSWGNGRVRGLSWSSDSEVLAVWLEREDRDVLQLWSMKNYHYYLKQELFSHSSSSPRFRSFKWHPEDPLSLYILCADSIQHRTFTWDTYVSRLGMPNDTASVAVVDGHRLLVTPFRTQNTPPPMSSYQIQLPSTPVHVSVSDWDDTASAVFSNGEVLTWKLNTRLPGPKGSKLRGGRKVAEPEVVLQKKIADGRVVRLVATGPNGKVAVLSLAAGEEGGRVNVFGGEEDEELQVESGVERVLWAPSGDILALDGESRLFSLASETGIDTILPSQPTSIMLSNDLLFTLSPTSKLHFTSLSPSADPEPISISSQPVTSFTLTSSHLIYTTTAHFCHFAPLPILEKLTQGEDVPEQDKQWEERRIERGAKVVVAAESEMSLVLQAMRGNLETIYPRAMVLQVVRRSVLGGSYRAAFLTCRKHRLDVNILYDLDPAKFMGNLEDFVKQVPEVDYLNLFVSSLKYVPIPPTNNKVNDICDTLRGLLEARGVEQYVETILTTHVCKVPADYEAGLRVLLQLQANHPEIVEDAIKYIIFLSDVNKLYDVALGMYNFQLVLMIAQYSQKDPKEYLPFLRELRALDKWDQRFMIDDHLARRESALSNLKQAGPEKFEDAANYLAKYELYDSAFKLYKNEPEHLTIIHDLHGDYLYDRREFTDAALGEYYTPYLLADKPTKALKAYERAHAWRELFSLAKKEGVSEEARKDLVERVTDYLASRGRHLEASQVFVEYTQDVDSAVDTCCRGAEFSEAYRLVSHHDRSDLIEAMIAPGLEEAQETLIEVFEEMEGQLDKEVKRLNELNGIRQKDPDSFYIVERELDLEGVDVATNATTATGISQFTRYTVAPSTMSHLTRFTGQTGVTSATSKKKVKKRATGRRGTVDEWEYLVMSLGRLGTRVEEKSGEAVGLLRHLVLASDDHRALAESLQSTIKAFRVKLVNGIDMAWEDRETVLREVLESGGSGLEGGLEKSMGEVKPKVAEWKGLGLLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4G4</accession>
    <name>A0A1E3J4G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="18" type="ORF">L198_04376</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031423.1">
        <property type="nucleotide sequence ID" value="XM_019176495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4G4"/>
    <dbReference type="GeneID" id="30193589"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="23"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN95758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="977" mass="108003" checksum="F64E9E9751F631A8" modified="2017-01-18" version="1">MGANDKPAVPTTPPHAWPVPEQWPAAKVRQTFIEYFQKQPQFEHTFWKSSGVIPFDDDTLLFANAGMNQYKPLFLGTADPKSDLSRLVRAVNSQKCIRAGGKHNGADLDDVGKDTYHHTFFEMLGNWSFGDYFKLGALTMAWDLLTRVYGLPKDRLYVTYFEGDAKQGLEPDTEAQQLWRDLGVPESHILPGNAKDNFWEMGATGPCGPCSEIHFDRIGGREAAHLVNEDDPDVLEIWNNVFIQYNREQSGELRPLPAKHVDTGMGFERLVSVLHDVRSNYDTDVFTPIFAKIQELTGARAYEGKLGEADKDGIDTAYRVIADHIRTLTIAISDGGVPDKDGRGYVLRRILRRGVRYASSKFNVKIGSFFSSLVPTVIESLEPIFPEVNSKRKELIEILDEEEASFARTLTRGEALFNKYAALAHEEKRTVLSGKDIWRLYDTYGFPVDLTQIMAEERGLKVDEEAFEKARLESLEASKAGGKEKAGAQVKLDVHDLGALEANDAVPKTDDSAKYGREDITATVKSIYHSSRFYSSTSELPPNSVFGVLLDKTNFYAESGGQEYDTGVLAIDGQAEFKVADVQVYNGYVLHVGQLEEGEIKVGDEVICTYDELRRWPIRNNHTGTHILNFALREVLGDHIDQRGSLVAPTKLRFDFSHNKSITVPQLTKIEEISNEWIKKAAPVYSKEMALAEAHKIPGLRAVFGEAYPDPVRVVSIGFSLEKIAANIEDKRWATTSIEFCGGTHVAKTDDIKDFVIVEESSIAKGIRRVVAVTGHDAHEVSRRAVEYERKLETIRGLQGKEKEAAMKPFLTELGQSGISLIKKSALKEQFEKMAGELAAAAKAKIAADSKIVTETIKAYFKENPNENVFAASFDVGGNSKTLAAAATAGKSTGKAIYAFSADPETGKIAHINYLPKEVVAEKKLDAKIWLNEVAKVLGGKGGGRDDSATGVGSEVDKIDEAIVIATTVYKKRVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4G8</accession>
    <name>A0A1E3J4G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031402.1">
        <property type="nucleotide sequence ID" value="XM_019176474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4G8"/>
    <dbReference type="GeneID" id="30193568"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="642" mass="69921" checksum="211D253E066353A3" modified="2017-01-18" version="1">MSHAAAEPSLLQLSAPVLPMATRRTGHPNRPQGRWWRAHQVKNVAVPAGGKEGYMSEEGFDSDATVRPGGGPAAPFAAPSSSGLARTERVMSVSIGQLEREGRKEGRAISKGSMSQPDLTALRGREREGRERMGRKEVEGWVGEVGRGQRQQPLQDQPKQDVDQGKRRPSLGRTKSVPDAPKPIIVSSSQIVEPWLPAAPSRSPHSRSHASLTSMRKSPSPRPTPLAIPTMSPITSKKNLVEPSLSPRSLKLEALPVVASADRDISSEEGDGDSESDGSLSFVSKRRALPGGELRQRLGQDGGVRFLRRSSSTGSDVLGLSFDSPSSAPTTTSTESISLPSSRSFSPLNSALGSSGAHDAPDATPKSQSTPMPPSFDQFLQRSSLFYLRLLAVFPAAWSIGVLLQAFVTGGLYVDVWPYGIDLSKEALERLVNGGDLMIGKWIDVNRGDILLCIAWAYCTGYFCFCLTTGLTHRWLSYYSLPSTITRLTSLQCLCWPMTYLTLWVLGARNSRPLLAWVVIGVTTGWSRTVQMWVTSNVVPSDLSPLASTTALGLGIHPNDSPSSYIHPSSRRGSKQHHRAPSVTMPMGPPPAHLSWWEQFLWGRRWDWDSVAREVGWRVGGLLLVTVAWLFWGIECGRIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4W6</accession>
    <name>A0A1E3J4W6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S small subunit ribosomal protein L22e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_04502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031548.1">
        <property type="nucleotide sequence ID" value="XM_019176620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4W6"/>
    <dbReference type="GeneID" id="30193715"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN95883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15492" checksum="A8CCFB33DE6EA1CA" modified="2017-01-18" version="1">MYPSQASQTSHSPRTCANPKITSSKTAPAHKFYVDASVPVNDSVFDLAAFEKFLHDRIKVDGKPGQLGDVVSVQKEGAKIVLTSSIPFSKRYLKYLTKKHLKKNSFENFLRVVATSKDTYSLKYFKVDQDEAEDEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J671</accession>
    <name>A0A1E3J671_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031606.1">
        <property type="nucleotide sequence ID" value="XM_019176196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J671"/>
    <dbReference type="GeneID" id="30193287"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="16381" checksum="F099BA5A55D38326" modified="2017-01-18" version="1">MSLATDYWPNLGPTDEQHRSSAVNHPANLALRFIMPPAPTPKQIQSLYTATITAAQGFSYNFQRYFIRRTDLAFKPVIASLSPPAGSSELPSPNDLAHFFETQRAELEVLKRASQVNKMFEGPKLVVEHAKPITSGGGAGMEASAGGGGQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6E7</accession>
    <name>A0A1E3J6E7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_04153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031685.1">
        <property type="nucleotide sequence ID" value="XM_019176275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6E7"/>
    <dbReference type="GeneID" id="30193366"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="82"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="14">
        <location>
            <begin position="406"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN96439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="646" mass="72021" checksum="09074173E6DB6947" modified="2017-01-18" version="1">MDYRNRGVSSDQYAVPASAAKKLSRLGPARQSMAPGQTRISVTGSSAMNKQIDSRDLLHSGAKGDGGVYGRTPQASRGMPGRRSSVFASSTQGRASLAPGVYSSTSRDNRPVRDKTFQAHCARNVSDYLVSAHYPAPITAKTLTSPTAKEFQSILKFLINNSLDPGAPWSKKFEDDTLTVLKDLKYPGLETVSKTALTAPGAPQSWPVMLAMLNWLADLCKALDRWDDPDCMTDFLKLPASELPLDFPGIEDRLLWDFSATTYAQWFDGEAEEFQEAEQKLEEAYKRLAAASVGECQRLQTQIQRYDVEMQQLQTQEPPLKRLEDEYVQLMGDKTKFISFLDLHRQKVDKVHQRVLKVKEIAESQEHELDNRRMELAKIEQAVNAQNLSPDEVSRMNHERDTLSRNLDELRNKIAEASQVAYDQEMMVTRSMDRFEALLADYNALAHQLGLMSAPAESPSTFTGAADFVIDLDLGAEELEEIKAAGLNMRSSLWQSLQTCREMYRQVALEVGNSAIVLEDEYDKLGQGVERQKEEVGNLEVRLKIVHQQADDAHVQLNTESADTNKVIAQLETEVTNMLAASQQGVLSTSSQLDSTRIAYKELRHKTALLQDTVVALIGEHIDVIIKAKEHAANSLKSIRALAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8W6</accession>
    <name>A0A1E3J8W6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031899.1">
        <property type="nucleotide sequence ID" value="XM_019175986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8W6"/>
    <dbReference type="GeneID" id="30193073"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="87" mass="9468" checksum="5508D0CFB97D9CC4" modified="2017-01-18" version="1">MSASSTKQRHYSALASRIRVLQSNLAETEGLTEMMAYQLDATAKLGIHCGSQFMAVSRLLDKELEAVQEASEQPEGQSTTNPPESPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J8X1</accession>
    <name>A0A1E3J8X1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031906.1">
        <property type="nucleotide sequence ID" value="XM_019175993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J8X1"/>
    <dbReference type="GeneID" id="30193080"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="392" mass="43097" checksum="D5F2BE6ABB43CFFC" modified="2017-01-18" version="1">MAPRASNANKKGKGRATQAQPESSDVEDEEEEVPSGALSNKDIESRAGMLVRFALFQEYRRVPIRRADAAKEVVPNNKRSFKAVLVRAQEILRETFGCEMVELRKKNEGAAAPDASVRAQQSQAAATQSKKNKGKGRARPSNGGLNAVEEEEEEDEEDDEPAATQRTKETGSGVYILQSTLPSSIIDFMNNPRPLPQETQDQVEEAEDSGALLPWDKADGGVIGHVGLMGLRTLILSLIMGLGRATSDDNLHALLKRLNLHRETVLPYSSKDNTGDLLTLDKFLDQLARTRYLEKIDIPGHGGGREGASCEWKWGARAEVEFSTKAAAKFIEEIMIGKEGESDDEEEEGQPRRGANSRARGEEEPEETNAHKRRKLKEDLVKASGLPLTGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J907</accession>
    <name>A0A1E3J907_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_03912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031951.1">
        <property type="nucleotide sequence ID" value="XM_019176038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J907"/>
    <dbReference type="GeneID" id="30193125"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="332"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN97349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="554" mass="60727" checksum="7DB5FF4E6107E9B9" modified="2017-01-18" version="1">MPSPMAHTQAAHSAPTQADLDILSRLTSDQSSSGPLNTNGRKKQLPRRESPIDALMISAVLAGSGPVSRHHFGHGIARTGAYASCDESRPSSPGQQTNQGLTSPKVVMKSAQAPRSQRVRMEREAKLALQRKFEAEKITEDVATAPTAGPSVTGGGPAPVDEEHQSGHAPDSSRYQRKMSLDPTSVTQLLSFPKPSFAYNHFHSYPSGSAAFNPIPNSLPGPIQVRCMARTRVPTPHGEIFLHLYHNSHDTKEHLAVVIDPVQLDPQTRSKAPEGRKEIRSKSLNAVWREGETEMERIVRGAYVGRLKPGVASSRGDGLPPVEGLQGVEDVKPLVRIHSECFTGETIGSMRCDCGEQLDEAIHQIGLPQRIPHRQNFHTPLSPRTHSHLPGRGVVIYLRQEGRGIGLLEKIRAYNLQDLGHDTVTANLMLGHGADERKYDIAAEMLRDLGLEQEGIRLLTNNPEKVAGLAGEGIRVVDRVGMVPRDWQCGDDQLHPNGAAEQGEKEEKDYEDWRMRRAGVGLIGSSKAQGPELEKYLRTKVERMGHIIDIPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBI0</accession>
    <name>A0A1E3JBI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Blocked early in transport 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032068.1">
        <property type="nucleotide sequence ID" value="XM_019176155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBI0"/>
    <dbReference type="GeneID" id="30193244"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN97466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="105" mass="11768" checksum="AD9AD6114C6F87FC" modified="2017-01-18" version="1">MASSGSGYTPATHDVEGQNDERLDGLLGKVKILKDITKGIGDEVRDSNLQLGNMNDSFASATTILSGTFKRMTKMATRQGGNWCWFMLFLLFVLFIFVVLWMVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBM3</accession>
    <name>A0A1E3JBM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032104.1">
        <property type="nucleotide sequence ID" value="XM_019175614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBM3"/>
    <dbReference type="GeneID" id="30192697"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="247" mass="27669" checksum="2D0B26DBE19EEDFD" modified="2017-01-18" version="1">MVFDIITATALCPAIIATKQAIDGGSKGNQRAGNKSINQELYVRFPGGHPYRRKFEGARVVLMNGKLYVEHADSHFAHNSIHPACGRFQSSPEYSAAWAKVGHKGDCLTTTTPSSTPSSSPSLIYVDLTTHELKYGPPEEAEDHYPGPWSCTEIEHRVLFEGWEGWVVVQEDAEKDLWALYFDRSDDGLTGEGKVGDFETTGVQMRMLYVRLARREEPRTIGKHEQEKAEGKKKKEELELDDDKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBX0</accession>
    <name>A0A1E3JBX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032240.1">
        <property type="nucleotide sequence ID" value="XM_019175750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBX0"/>
    <dbReference type="GeneID" id="30192835"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72507" checksum="3CCD7FF89EAD690D" modified="2017-01-18" version="1">MQPEAPPHTPDNPTSPARLFPHHTPQPADTPPSLRHRTPRHYHHHDQPAHINTVRIRFKTPHSDAEAGLDRIKEGWEFDQDVLVGDIKNRLSEGSLEGAGRWVRDGMRFVYRGQILKDQQKIKDALGADPSNDQVFTIHIVARHIADSFEYAAGSSTAALAAVTRIEEPTYSAAQSAAYSSLNSFAVLESIHFILFLSRYNLSVILGLKPMEWHETSPPPIVDIEEARQGVISVIRAFAGVRMASEEGWEDWHIACSGISSEEMTVGYTDPAQRGVIENDIRSTFSSLVGRNWTDRYSRQVIETEIEGHVYTVQLPSMDQCSPEILARLYVYLRQLALVPLLNNVLYDAMSQQQQSQPAFAPTPAPTRTVPVPPILIPTPTLASYGTFLYHFFHAFYGRLDGILLRQLAFATIRVFFLFSMFTYSLKWTDPMYWVICAVSALWWASTYWPLFTLAWRSAWWETYGPLEDAIRANGERRGGPQGRDQAAPRVAERQIPTPRNHTSMPRGHLLARAHLATDRNLIAARRRQPPPWWQTQLALPIVLWVITLIPTYEAQRARIIRLRERAMRERALPAGGDTAGGAAGEDNVPTPEPVIPEGLAPVARRYYERVLSRTERIDWDEEREAQRAMGAGEDGEGGAGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC66</accession>
    <name>A0A1E3JC66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032301.1">
        <property type="nucleotide sequence ID" value="XM_019175811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC66"/>
    <dbReference type="GeneID" id="30192896"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN98439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="251" mass="28091" checksum="A98EAA550BCDAC82" modified="2017-01-18" version="1">MAPASKQKSNVALLTEGASYIQRAKKARKDQVEEIKFDDEARREWLTGFSKRKKAKVEEKRSRAKEREKQEHLDERKKARKELKERAAANVKSVRQAMGLVDESEDEDETNEAGPSSAAADEEEEFSDDDQIATVTITEDFDPTTTSSFIPTRSSQSPAPEETEAPAPEVKKVKMLPPSSKRAQKALDKKKAQSKDGKKVGRTTSMETKAERRKGKEIESRKRGKKAALAMERRGGKTSSTRGKPKGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCB5</accession>
    <name>A0A1E3JCB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032361.1">
        <property type="nucleotide sequence ID" value="XM_019175871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCB5"/>
    <dbReference type="GeneID" id="30192957"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="452" mass="49593" checksum="2E283E27B92B8479" modified="2017-01-18" version="1">MATRTYAALVPWRAVAIKQRVPQLVGLRTSKRLSTSATEVEERPLSGVKVVDMTRILAGPLATMMLSDLGADVIKIESPKNGDDTRSWLPPSAPIPLKNYPRPDLPPESAYFLQANRNKRSLTLNLKSKEGKKVIHKLIQEADVLVENYVPGKLEKFGLSYEQVREINPKIIYCSITGYGSTGPYASAPGYDVVIEAEAGLMHITGEKGGKPVKVGVAVTDILTGHYAQSGVLAALIKRGKTGKGSRVEVSLFESQIASLVNISSNYLIAGQEAGRWGTSHPSIVPYQVFPTKDSFIMLAGGNDSQFAILCSPAVLDRPEWINDERFATNQSRVEYRDTMVKKLGEVLSEKTTAEWCKKLKGKGADEFVYSPINNIAQTFAHPQAVAREVVEEVDHPRAGKIKLAGPAVSYDGSKFKLYRPPPYLGQHTDEVLLELGYSQEEIRQLREDGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JE06</accession>
    <name>A0A1E3JE06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032198.1">
        <property type="nucleotide sequence ID" value="XM_019175708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JE06"/>
    <dbReference type="GeneID" id="30192793"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN98336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="209" mass="23248" checksum="3A4B7F29AB010E2C" modified="2017-01-18" version="1">MSDMTESDDEQYKDHRVLASHPSQFKILLMPFISPAIYRSTVQAARTRLPTATARSTAGITLPFALFSSSAPTNDMSSQPKVQKSEDEWHAVLSPEQFRVLREKGTERPGSSPYDHSFDDGVYHCAGCDAPLYTSKTKFQSGCGWPAFYDTVPGAVNRHEDRTLGMTRTEITCNNCGGHLGHVFKGERFGNPIDERHCVNGISLNFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JEW8</accession>
    <name>A0A1E3JEW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_03229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032464.1">
        <property type="nucleotide sequence ID" value="XM_019175361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JEW8"/>
    <dbReference type="GeneID" id="30192442"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN99387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="96" mass="11332" checksum="444B778A2BDE97FF" modified="2017-01-18" version="1">MLATETELEIIQWNKTLGKLSMSQLEERISVEFRTWQKVMSCGLPVGLEHNHPLRFDRARHAVPLTHNDWRHIEACWNVVVSEWLVRCLWSPVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFX1</accession>
    <name>A0A1E3JFX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032632.1">
        <property type="nucleotide sequence ID" value="XM_019175529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFX1"/>
    <dbReference type="GeneID" id="30192612"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="545" mass="60590" checksum="DD065DFDC163B693" modified="2017-01-18" version="1">MADTAAATDVLMQEDTAPATAAEGSKRTNTHTATASHEPQEPLSEVMFRRVTRIKEGDNVMLRLPSDLVKSIVVDKETLVQLGKYGSFPATELIGLHYDITYEIIPGSGSKAGTPAVDDPVAEEPAAAEGSEKKKGKKEKKKVWKGKEVVVPKSNPGWSNILRPMKPARLADVIVDDVAETNELIEDLPEDSKGMLTQEEILELRAQGLTGDQIIEAQQARHESFKLKTDFSKEKWRRRKEKKFYQTICPLAPTIPNLLYHYTSRSANTILYLRDDTLAQMLTMANIRPGGRYIVVDDTGGLVTAAILERMGCEGRILLMTDNDSPPSWGVLQTMNFSRRELEAVKWLNWLQAEESYERSAAPSADEPEPTNVQKAGVKQRRRAAQIAELNNTRNELHLGGWDGLIVASNLSPLSVVPRLTPYLLGSSPLIVYSPYQQVLADLLSWSKKDPSFLNDTLSESWERTYQVLPGRTHPMMVTSATGGYIWSAIRVHPSAFQPESHQRFKRRKNNKAKAAEPTETESAGVAETKDEDDAELALEELANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHW4</accession>
    <name>A0A1E3JHW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032588.1">
        <property type="nucleotide sequence ID" value="XM_019175485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHW4"/>
    <dbReference type="GeneID" id="30192568"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN99511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="271" mass="29528" checksum="528731B7B32B5A11" modified="2017-01-18" version="1">MLVKTSYRDVPTTANGKKGTIRIFLVEPSLPGYPNAKFPGCVVFSEIYQVTGPVERFASNIASEGYVVALPSSFHEFEGPEAIPYDTDGTDRGNRYKIEKTVEAYDEDATLSIDLLTSLPNCTGRIASTGMCLGGHLALRAAFDPRVQATFCYFATDVHSATLGAGKSDDTIIKVKNGDLTGKGEVAMVFGKQDTHVDREGRSLIRDTLDAANFLEVQAQHAFIRDESSKGRWDAALTRSLFGMMMELFNRRVARDLGEPSGDGGKVEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JI08</accession>
    <name>A0A1E3JI08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032716.1">
        <property type="nucleotide sequence ID" value="XM_019174984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JI08"/>
    <dbReference type="GeneID" id="30192056"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="113" mass="13182" checksum="BB95EF23339B4D49" modified="2017-01-18" version="1">MAILHPETATRAPDPPPLVRRPTSSQINTYNPRKDLPPSLKKGGYHRHNDNYVWWRPYGLPLPMFSPNMVLPPAEKSTTWKDLRLITFEQKGSSTWYTEYPNTRRAMEAAYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIC0</accession>
    <name>A0A1E3JIC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor 2 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032780.1">
        <property type="nucleotide sequence ID" value="XM_019175048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIC0"/>
    <dbReference type="GeneID" id="30192121"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="184"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="314" mass="34530" checksum="2AD980BEBF84AE69" modified="2017-01-18" version="1">MKKKKKKVAVAEPEESPASPAPAVESTPEPTPAAAPAAPEPVAEAPVAESSEKPAEDGGDLFADLKKKKKKKKDIPLDLEDAPAPTADGLDIPMKKKKSKKTTDFSKELEELETEQNEAAADDGDLGDDPFSTKAPGADPSASELLEAGKEPWVLEAREPTYAELLKRFFSLLHAHNPELAGEKRRYTIVPPQVQREGAKKTNFANVMDICRRMRRQPEHVIMFLYSELGTTGSVDGTQRLVMKGKFTQKQIENVLRKYIVEYVTCKICKSPDTILGKENRLYFMTCESCGSRRSVSAIKAGFQAQVGKRIKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKK1</accession>
    <name>A0A1E3JKK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032839.1">
        <property type="nucleotide sequence ID" value="XM_019175107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKK1"/>
    <dbReference type="GeneID" id="30192182"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO00647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="220" mass="24048" checksum="46A63A17642EB8C0" modified="2017-01-18" version="1">MSCSHEAHDHDHNHGDHAGHDHDVPLESSPLDSLYQQIDLPNVVALNAEDGREAGKKVIKSWDMKEDDTIWLESEVDDELIINIPFNASISLRSITLKAGPAGHTPREMHLFRDNLALDFSDASSTNPAQTFDVVPNRAGVEYQVKAAKFNGLTSLTVFFPGNTAEDDEETTKIFYIGLRGSHKPLPNRPGAIVYESNANPADHKIPGVNAGGTTSRPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM79</accession>
    <name>A0A1E3JM79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033206.1">
        <property type="nucleotide sequence ID" value="XM_019174827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM79"/>
    <dbReference type="GeneID" id="30191898"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000061">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000911">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="367" mass="41244" checksum="B7C5D4518CA76B41" modified="2017-01-18" version="1">MSSRILNVAVLGCGEVAQIAHIPNLVVASDKYKVTALCDVSQQSIELCSSRFSIENTFTSLTEMLASSVPIDLVFVLTADQYHAEHLIQCANAGKHVMIEKPMAQTLAEYDAVEEARVRNNVVIFVGYMRRYAPALERLKKEIEGKQIKYVRVRDIIGNNSYFTKQSGMHQHYFKDFPPSASSDLASRRSANLLENLGADAEKDPRNAASWGLLHSLGSHDLSAMRDVIGMPERCVVATRSDDEGGNAWWWTALFQYKGFRAYYEMAIDEVAIFDAHIEVYTNDSRVKIQYDTPYVKGLPIKLTIQKQLPNGDFSEQVIRPTYEDPYTLELGLIYEAVVHGVDYKTTPLDAKNETVLVKMIMDALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JM92</accession>
    <name>A0A1E3JM92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033230.1">
        <property type="nucleotide sequence ID" value="XM_019174851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JM92"/>
    <dbReference type="GeneID" id="30191922"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201:SF9">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="558"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="853"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO01978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="881" mass="96035" checksum="6A19DBF363BB4B8B" modified="2017-01-18" version="1">MPNSTTQELMTDWTPRLGSFGGSLRRDKDNMDIGGSPYRTSPHGSPTPQGQTLFINTPHSTSHLAYPSISGSPFPHVPHHRHLASPLSQSQSYYPSPHGGFEPDPVQWQAHGRSPTYAEGSGQLQYLGYYTGEQGLLSTSALERPYSAHGEAISTMSQRKRGKQPMRGSGGMGRATPKRGRSEETLGSAKRLRVGGPEQERYMSPAAYPGPSGHSGAQDMTPINEIPEDPANGGVPRPQPEGAATGEPEHRPLVITRHETEGRKLGLLGIARGELEDSKTPEDPPLSPRMTTIDVLETDESGRAVLATREVLETELTWLDPNNQMTPPSSPKRMSFQTPVAPRKQAPQEEEQTDEENSEPALEREANQLSKRLQAFTEAMTHDEQPLVSTRIEMFGRVAVRKSTAFSFLQLSSSEGSAAIEEFKADGKEDWEVESDESRVFRPFVRPMWPDNEAPWALAGGKMKDRIRREEGAKAHTLRRYLETSSDESEEEDEHPRFFRAVRQTGHWGRGKGKSISRLLPMEMRERERRMDRTSARDALLSSLRSRPVPVLPAGVVACVCGATAPNELGSMISCAACRTWHHLVCNEFEDVAKVGPNWWCQSCTANASGLRTPVSHTPTRSYSSIGDPRSSAVKSDINHIALAPSPMFVNSGNISAARTPVTRNPGSSPQRPKHSRVLSFGGDMWAFQEDAAPSTPVPVVHDRYSTPRISDTPFDVTSTPSRHLDFNFGQPSLFSLTPLGGRSRMPSTVLIDGTPVMRATPRNTSGHGGALEPMSVPSRADFFRELNKGNGPHSAGPSLGHHHSNAAVHHMVGSASVGTGDRELPASPRWPHSLLGAQLSPSPFGGGHRRSLSGNKLSSMRSSSRSGLGTGYGVAEEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMJ4</accession>
    <name>A0A1E3JMJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_02809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033330.1">
        <property type="nucleotide sequence ID" value="XM_019174951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMJ4"/>
    <dbReference type="GeneID" id="30192022"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="394" mass="43187" checksum="7FC25D3A29906B72" modified="2017-01-18" version="1">MQSSDPGHLFQTSAQLAQAATRERKLKAAEKVGNPITLSSKIIDLQILASHAFTAESGWQARRVDLRTGKTVKLYKGHQGPVTSIALTKVTGSDGIPWTALFTGSWDKTIRVWNADSGELIRTVQGHSDFIKSLTLIPTPSPLLLSTSSDRTSRLWDVASLLKSEVEGKPETRQIIKDHTRPVECAAWKNELDAEGQSTGVLSVWTADSLGVIKQWIVKDEGLEFVHDVKGHETSVARLIPVEDGLWSVSMDKTAIFHPTTSSPKTTIPHPSYVKSILPLTAFPLPNAASLVLTGSEDEDIRIWDVEANPPKLRGTIQGHCGEVAAMQSWMRETNGQAELVVVSAGLDASIRTWTVKDILNPPPLVYEAEEKQEASGMTEEEERELAELMSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JML6</accession>
    <name>A0A1E3JML6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_02836</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033357.1">
        <property type="nucleotide sequence ID" value="XM_019174978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JML6"/>
    <dbReference type="GeneID" id="30192049"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="85"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="399"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO02105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="63083" checksum="3476CA5BC12D6C88" modified="2017-01-18" version="1">MIAPPTSQSELHLLCVSAVVRDLITAYNSNNSSATQQIPNVNSIRAKYSKKYSLKAVPRLTDVLAAVPEEWKDRLRMWLRAKPVRTASGVAVVAVMCKPHRCPHVAMTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGRVNQLRDLGHSVDKVEIILMGGTFMSMPEDYRHKFIAGLHNALSGHTTDDVDEAVKFSEQSKVKCVGITIETRPDYCLKPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVSESFHMSKDAGYKIVAHMMPDLPNCGTERDIWQFQEFFENPAFRSDGLKLYPTLVIRGTGLYELWRTGKYKNYPPNALVDIVARIMALVPPWTRVYRVQRDIPMPLVSSGVENGNLRELALARMKDFGAECRDVRYREVGLHEIHNRVRPADIELLRRDYAANGGWETFLSYEDPLSDILVGLLRLRKCSEEGTFRKELVGMEGGCSLVRELHVYGTAAPVHSRDPKKFQHQGIGTLLMEEAERIAREEHGSGRIAVISGVGTRDYYRRLGYFLDGPYMVKDLLYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JNY6</accession>
    <name>A0A1E3JNY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_02574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033099.1">
        <property type="nucleotide sequence ID" value="XM_019174720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JNY6"/>
    <dbReference type="GeneID" id="30191787"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO01847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="691" mass="78529" checksum="4731E7A1AB142A8D" modified="2017-01-18" version="1">MTIFVMLFAGVNQFFGLRYPSLTIGYVVAQLLVFPIGRAWEKLPQWQIPLGRFSFYLNPGKFSIKEHALIVICVNLTASTAYGMGALVAIVSPEYWDRESDWGAGFSFFYLLTSQSLGFGLAGLSRRWLVYPAALIWPTTLASTVLFRALHEPQDHSPANGWTITRYRFFSYLTIGAFVWYWFPDYIWTSLSTFAFATWIAPNNQKVNTIFGMNSGLGLLPISLDWTQITYAGQPLTTPFYITCNAFATIVIFYLFLSPILYYKDVWYSGHLPLLSSSTFDNTGGTYNITRVIDSNLDFVLSQYKEYSPMYISMSYSLSYALSFAAVTSIVIYTILYNGKEIWAKFKNAKHGGEDIHKRLMNEYKEVPDWWYAILTVVVLGLGIFTIRYWDTQLPVWGFIVVCFGMCVFLLVPEGILEGTTNQRIFLNIITELIAGYAWPGKPIANMMVKTYGYNSVKHGMDFAMDLKLDQYMKIPPRTLFAAQLYSTVLASMTQTGVLRWMIGNIQDLCKSTNKDRFTCAGAKVVYNASIIWGTIGPQRMFQHGQVYSSLMYFFAIGPVVTVAVYLLYRRYPNSWLRLVNVPIFFNAAGNIPPANTTQYSLWFIFGFIFNYLIRTRAFAWWKRYNYLTQAAMDTGTALATIIIFFTLSYNGITFNWWGNTVGSDTYDANSVPAFQAATGSHFGKGVLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JPL0</accession>
    <name>A0A1E3JPL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033104.1">
        <property type="nucleotide sequence ID" value="XM_019174725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JPL0"/>
    <dbReference type="GeneID" id="30191792"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO01852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="88" mass="9588" checksum="F842AF75238D7C42" modified="2017-01-18" version="1">MSTLTPSLANTTAASSPMPASPRPSNEGDQAQIASKDAQDAQDDQEEADEDKQVVEKMIEEAQDDPQGVWFVWFKIAYCDAPLSCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRL6</accession>
    <name>A0A1E3JRL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_02369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033572.1">
        <property type="nucleotide sequence ID" value="XM_019174520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRL6"/>
    <dbReference type="GeneID" id="30191582"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO03521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="66450" checksum="A109A1E242F52E65" modified="2017-01-18" version="1">MSISTKLLEEYMEKKQQGVPDRSYSNSVLEGRVNNRNQEFSIASRRPLRMDHGGNSMGDRSFNGGYSGVQGGGNQSLADSSHGNGSFGFGNGTFTSTQRGCASQWSEDRVEQIQARLKRKLGPEYVTQRPGPGGVQKLSYIEGWKVINLANDVFGYNGWSTTIVSLKPDFIDQTKEGRIFVNATAIIRITLLDGTFHEDVGCGQAENVKSKGAAIDKAQKEAVTDATKRALRTFGNVLGNCLYDKEYTKEVVKMKVPPAKFQSDGLERRAEFAPPGYSHDAAPGPSRSNSIPPHMNTDNRPPLNNNILPPRNIPQADPQPPPPPMRPPPNIVQATPLKSVHSGDGQEDEYFFDENFDAEFAQFDDASMMAGVDGAGPSSGANTSVHSEPSKPERPAYQHRARPDLSKSVSEGPAKEASFQKPAPPQAPQFGRPAQHAPQAPVANGVNVHHAPGLEGQKTIPSNSSPVDRGVFGKTVSAPVAVGKQPPKVVGGFNFPGPANKPASSRAQAILKGLNGNTHPSPHLKGPESPRIPSGGVDHAALRATSRLATEGARLGFDENDEAVAADLALGGFASAKGLKRAPPGAERISHSPSPTKMSGGVQGRTALGELDPADWAAKRSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRQ8</accession>
    <name>A0A1E3JRQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033407.1">
        <property type="nucleotide sequence ID" value="XM_019174355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRQ8"/>
    <dbReference type="GeneID" id="30191415"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="472" mass="50174" checksum="4C83677F2B2DDA23" modified="2017-01-18" version="1">MSTKFILTAQKDTLPPAPALSLLPFSLGPTNAPYKATDANISGYFCPRPIAAPVGNQSEGQDAHAAQNLQATFRGRQLVGQELALPPSYRGVILSTTLPPNKGGTEDHSASHHTPLTPAASTASVAPTEVSAEGEEKPVTGESSSRHQRKSVLAKIKGAGQIALSRPRITRSKRPEPKKRVRLDSDDEDELEVPVEEPKEAKRPRISPSTPGKPLDVPEITIEEPTPLKASTSTTPSSLRQLRSGTPTASPRPSSVIEGELPSLTEEGEEGDEGAGDGADAVSVEVQEVEDQKEDMEEQVIPSPATEDALPTTPTFNVPPPPIESPDKEAARLATATEEAVKEEHEDVEMKEEADAEEAYGGPVRLLRPTATFDRFVLYTGDAPLAGFRADELEASSAPTEPPAESPESSAPAPAGESTIDGGIQVRPSWWRLGGSGEGGDEFVRGMGEWLGLVESMNKPVYLDGIEDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JW44</accession>
    <name>A0A1E3JW44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033733.1">
        <property type="nucleotide sequence ID" value="XM_019173926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JW44"/>
    <dbReference type="GeneID" id="30190978"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33457" checksum="4441B8B3B1E8535B" modified="2017-01-18" version="1">MDLAHLPVELIQHIHVLAHNPFLPHTCRYIYASLHGTSPHYTAAYLLSLYSPYGPSEILLRALRHPVCNIDVAKALNEQWEKRRRMGNGKSAVTSFDPMLGKRARSELGSASPEPAIRPLAVRELPRRLFRVSKPEPPIHPMITYIFETYSPSPNSHKGYPLCRAVLQHNLPLISFLLVHGADPSLKDFMAVEIAISMKDLQMVRMLIERQPGEEKKTDSPAKRVKLGDRVTVGTRMVETAIKKGANEIVNYLVHDKKVMPPLQSIMELGKPDAPISTPKSRPKQKSNKRQRQAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWF3</accession>
    <name>A0A1E3JWF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033844.1">
        <property type="nucleotide sequence ID" value="XM_019174037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWF3"/>
    <dbReference type="GeneID" id="30191091"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="366" mass="38929" checksum="1227CA0B534ACEA0" modified="2017-01-18" version="1">MAPPAQPPSSAPAYGNFRLASRPENNGPSNFRPASASANGTPLGNSKPPGAFTVFVRPSAVTHEHPSDAQEVVYSPPSSDNQTPRVSQPQVPRASLHQTPRVSSPLALHVSTPPTVSAPSSIVVEPSETAPDTMILDDESAPSEIVDDPLFLGPDVVSTDEDRDIDIQPCRPETSNPLDSFPSLSISREPPVRHDQSPAIAKAHFATDTEGSPLRDIVIDSGAAITLMNAAYANEHLPTLTRHRLEKFQLGLGAADCASFLMTDLHFPTAEGGKAVIPANFYLANTESARVILGNDILHPMGAQINLGSLALRFRHVAGTIPIECTTAIPDAAPTPDPTTRPDAFRLRQRLTLLPGHQARVARLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JWJ2</accession>
    <name>A0A1E3JWJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POT family proton-dependent oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_01919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033884.1">
        <property type="nucleotide sequence ID" value="XM_019174077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JWJ2"/>
    <dbReference type="GeneID" id="30191132"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO05229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="631" mass="68156" checksum="1B04A691AA771409" modified="2017-01-18" version="1">MSAHTNAIVDLESAPVPSSALPASTDDTKAAGGPITLTYSGDKKESIPDVSVGAAGALDYVSDEVEPTDEEFAILKKIPGKMPWVCIAMCLIELAERASYYGITGVVQNFVRNPLPRGGNGAGAVAPGSAGENQSAGALGRGSVQSSAIYNAFVFLAYVFPIMGGIVADTRWGRFKTVVVGTAIGGVAHVLMVVVTIPQVLAKGSTAALGAFLPFLYILSFAAGFIKPCLATLLCDQSPVKRPTITTTKTGERVILDPQTTVQRYLLVFYWCINVGGFFAIASSYSARFVGFWLAYLLPGIVYMLMPIVLVVCYKRLYKAPPQGSVTLEAIKVVTMIIKKGGIIKMFKGGDAFWQTAKPSYILATEGQVDHTKVFWDDKFVDEIRQSIAACGVFALIPIFNLADGGIGSQENDMSTSMTLNNAPNDVISNFNPLTIIIFTPIITYGLYPFFEKIGYPLKPMTRMTIGFILGAANMVYGAIIQWKIYEVSDCGYYASTCETVTSWSIWAQIPLYSLPAIGEIFVNVTSYELAYTRAPARMKGLVYALCLFNQAISSAIGLACANAIQDPYLIWPYVALAVACMICAVLCPTYFRHLNDPIRDFADPDRQAGKLQETEALIEDRAASPVREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JX26</accession>
    <name>A0A1E3JX26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034050.1">
        <property type="nucleotide sequence ID" value="XM_019174243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JX26"/>
    <dbReference type="GeneID" id="30191301"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="661" mass="73273" checksum="04D85D1AF1CD076E" modified="2017-01-18" version="1">MTDFTLNLHQSHSLITTLLAHIHAFPTERLLYHAPVLDRIYIPTAEEKDAERVEERRRVWRQDEVFGLRKFVDIVEHHESVLRNMIDHGIPPQEDPLPSVQGMETFWKILITTEPPIVGVKMPMGGNAGGALTPKGQGKGQQKKGGKKNKDCWVDVIARGGNEWVRVYSKKISHLLAEFREQDSYVNSDFDSSSEDEGGASEPKKTNGDHDPDLSNSLMQTAHDLLRASASAPRIPGASQPALTIWLTRIPDSPEEWPDRRIPKTLQALGHLGITVRHLSPPALDTLTGYPVPKRLQPSMNINFDITALLGLTSDVLHYPLPKSREEAGARSLRPAGELLGTGSLARGRDGTGRGKGKGRKETDAEGEEGEDDVLRGQSQNSRELYRCILEEMGRPWIEEFNSVILAAWQSHPSYSPSSSTPPPCEFWATKQAAQYTFEALTSGPAHGEGMEQRRMKRMLGYEEGDWLEGSRYEGKGGILEGLKIRVFDDEDDTVGEQVDKTGLHKTLEAISGDFLQDYYASLAPPPTSKSSKLPTPSLPNFLQPKKLPSPPVAKITLPFPVVSLHALHRGAKEGMTTVMMGTATFKEVWGQGRWKVRGWERGSYDLAAVDDGAGGEEVGEERKEKGSAAVMIFPYRVFGEGKRVRFEKGDYAYPAYPNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JY06</accession>
    <name>A0A1E3JY06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial splicing suppressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033732.1">
        <property type="nucleotide sequence ID" value="XM_019173925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JY06"/>
    <dbReference type="GeneID" id="30190977"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="217"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="529" mass="59472" checksum="C46F047F16F15092" modified="2017-01-18" version="1">MRPLSAAALRPLARSTTRLTPCPLPSHARPFFGLFKKSTPAPAAPQAPLLAEDDLFHPLSHSPFPALVEKADRIKSVSLCPTSFEKHHERVRPAFDCPDCGWPTHKDQERWEEGREEHKEYCGRLREVNEDEHDLRSERKMVEFENMPEQQPYESAVNFASWDTLFFTRNYPSIDSDRSVRHVSKILTYPMTIAGILHQNGPFTSGNGRITRQGRRSMAALHSVLHLPPGATVETAPEKPQPPFRLFLLGARAESTLPPHLWAQLTHLFPRTVFQIYFIGPEVGMPLLSAQDRAKQEYAFTEEGGWGVPSYTFNYNTQLSLTSLKAPYEEIHEQLGPFDPYTDVFFAFSPGFGFPHQPLLEKITKSGKGQVLLDQETGKPIAPEDRYSPAEIESEVPYAPPETLVQAQTSWRQPLQQILETKCPFFFTAFSPLDLQRDVSALFGTNPPSASGAPGSPVREFPDYVALPTGPIEPIEGVTDEFELVLTPGVNPFGSLKWEIAEWDVRVGVKTNWGTWGIRGKKYDVVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ93</accession>
    <name>A0A1E3JZ93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Topoisomerase 1-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034193.1">
        <property type="nucleotide sequence ID" value="XM_019173488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ93"/>
    <dbReference type="GeneID" id="30190537"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1181" mass="134135" checksum="7A2EA2B7E641E2F6" modified="2017-01-18" version="1">MDDNRPPSPPPFLDAPEHKYDLFYNAVQTLVNALGGYEDIESPPGSGHFDTIYRPGDSVLGVLKDLKKLWRKDDEDDERTVARCMAQAGLMKELVAILVECADRGEWGRKVSLVACDLIAALTWPIDVAQELKEIEEEGPIITDYASLLRAQMEYKALFLKSDRPLRALLALMVPCLAKPRKDEKDTRIISLGLHVVRNLLAVKDASAEGTATGTKAEMAQLQSDLICQLDSLTYLQLFLTLASCSDKSDLNAFNVIVLDILHLIFRGVKVQELGQDQKRVPLDNLAKLLDGEKKQKAMSSKSGYTRHSRFGTTITVKTAEQRVVLHKQNAVVQDAGKILDAVKKGKKAPPKKMDELTQYITLSVEAMIVLQNFCRAFLETAFNTFFEYILRDIRMERTKIRPSDNIRVFYLTRFFIEYLLLLRNKLYDKGGSRERDELPLGLVAQMAEMDSVKWLFARLRISWDDKPKAWTELQACIDCFTQILLLIDDMATSPDEEDVEVAEIMQHQLYYNYDILDSALSVVREYKNQSIAYLDSIIHFAYVLLRMLERYSKTKSFMFIRKRKNTHRKRKEQQVDPNDSEEVRRRNIPEEYGNEEEADQGPDQDAPTYEEHAFTFQGFEKRFATEAIVNTLLVYLERFLEFDSAEQVKRVVGLMHRQVVKTHAEGLFYKVTTMILFQRILENKHALPDAPASRDLTTLITFILRKFFKHVEKDPYIIIEVLSTKARGKWRGGGGESDDDGMGGQKSRIKEKMGPAELAFVKKHNLSWSKQMSVVFAILHEAGQGYLIKWIIGVLEEVLAARQEIVLATDGGMDVDEDEDGNVRARNFGGPSEEAKSKFVQYDLQPEDDEQTAAIQKNQHFRLMLKLLSFDIPPPPTELDFEEDISPEQLAAAVKKSNYAWHIPEDVVPSNLEASIGALKQYMEDPPSLDEDPKKLLRRKPRAPRRRRRSPSVQSYDSETGEVRESTRDSRPKNNARRKKAKKAAETQTFKSAAFIEDSDDEDEEATRRFFENEAKLRAEMDALAANGGHSMLDRGVKRKRGAGKGKGKKGKSLEIVDSEDEGLPLPSSTPMNDDVEPESDRGEHGATTRIVTEEEIAAMNRRKETLADMRRMAMESDEELGDSGSDEDHEGRSMRPVVHSSESGMPIFEEAGDDEDDDEVRAPRASARRVVMDSDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZK3</accession>
    <name>A0A1E3JZK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034349.1">
        <property type="nucleotide sequence ID" value="XM_019173644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZK3"/>
    <dbReference type="GeneID" id="30190694"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="96" mass="11371" checksum="6EC8E19394555766" modified="2017-01-18" version="1">MGQWEIVEEKEYYDDLSTELELADDDDPPTLYKIGESFFHLPLRDARRQLKKDMKRYETDIEGLEARAEECEKGMKELKVHLYAKFGKQINLETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZV8</accession>
    <name>A0A1E3JZV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Two-component system sensor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034436.1">
        <property type="nucleotide sequence ID" value="XM_019173731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190781"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000307">
        <property type="entry name" value="Receptor-like histidine kinase BpdS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000230">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.240, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="621"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="912"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1504"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1474"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1650" mass="182201" checksum="31CADF1A3CC8988C" modified="2017-01-18" version="1">MSVGSTIDLSSLPIAFLELDGDEDYPDGSSSPPYRAGTIVWRNAQWKKLAPGETIGECLSPLDQNRLQAWMESAEYGEKAETLAVDIKSAEGTTLYLAKTILPPSPSNGQRSLCILTSQIHDPPEVAPPSVSSSIDRASPGLLGPSSPFPRSLSISSNGSRPVDAPTVDTRSSTTSTSSLRSSVDLTSPDVQSPFQTPIRTHTPSGKTLSIQDDRKSRKRSPRGTTPSIKSGTMESQAAERWRLVESFNWAKTPIGPREQWMDALDPVLAITFESRTQDCAWLGPDLRLVYNLPYQELINHPAAWGQPASEVWAGNWDYLEPLVKKCLSGTPIYKDNDAIFWRRYGNDVLLEHYHTWRYVPITGKDGSIMGIFNQSMETTDTILMERRLNTTRELSEQMTFARTLEDYFDTVADVFRQNPADMPFALCYRVHQKDADALTITLECDLQVTVGVPDDHPSAPQSVPVDIRNKTTFGVSPPRPTSPTASMLSAQSANNNRVCHIADQFQSWPLKKAISTRQCVFVEDCSRMISGFPIRQWNELPISAIVVPICSEGSHDVPGSVMIFGINIRRPFDSEYELWMNSLRALLASSFIAVKSHEAEAKMAEDSAKMEAAKVAWFRGAAHDLRSPLTLIAGPLSDVLESKLDPTQRTALTMAQRNLERLMRLINSLMDFSRVEAGRMEGRFVPTNLSEYVAELAALFKPAAERLGLQFIVEIEPRQELVLLDPLLFETIIANLIGNALKYTESGSIAVRVSYTSGQGEISVTDTGVGIPKDELALVTEWFHRSSTALHSGTQGTGLGLALAKELLKLHGGELHVWSQTAGEAEGTHGSVFSATIPLDFKPQSSSQTQSPYFVEEFGKYGQIVADEAMRWAADADEASEVSDKETGSGGSAASSGNRFAEAFLFNKKDVVLVVEDNVDMRKYIAQLFAPHCTVLQASDGKQAYDMAVKKPPNLILADVLMPKMSGMELLQAIRSHPDTRIVPIVLISAVAGDEPRMEALLNGAEDYMAKPFKPKELLARVHLHLQVGKKRAKLEALYAQRETELAVLSDYCPTGIFRADTKGHIVYTNNAWRTQSGIDDSDPDSWPMYLTQESHHSVLELWRAWVLGDEKSMKTSWRWANDTPVRASLVRLEHAKHGFSGVLGCVVDISHEERRLVEAEERRREAEESKHQQELLIDLTSHEIRNPLNAILSCSDLVKQNLTTLQEQLRASGLNGFIPSPELLSDLEQDVEALESIHQCGLVQERIAGDILSLARIQLEMLSLHYIEVNLRREARKVSSIFASEAKMKKVDLTLTFGPTIEQSQVLLIKTDPVRLGQVVTNLISNAMRFTAGVDDKKIIIQYDVSFVPPAEDTCALPSDIGLPTTLPAPEDTPVWLFVSVTDTGPGMSPSELAVLFQRFAQGNKMIHTKYGGSGLGLFICRKITELLGGRIEVLSELGTGSVFRFFIKTRAVSPPTAMAAFVEPTALTPISSSSPSSSFSMSRTSSNQTPKKLVSREEGDRILVVEDNLINQTVLKRQLVKAGLSCDVVNNGLEALNTIRENNRQYRRGGVDRTKLYDVVLMDLEMPVMDGLTAIKEIRSAEAAGHLERNMVIALTGNARQGQIDQALAEGMDDVVIKPYKIDKLLMKIKGMKAKRSELELNVIEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K041</accession>
    <name>A0A1E3K041_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L198_01661</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034529.1">
        <property type="nucleotide sequence ID" value="XM_019173824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190874"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000051">
        <property type="entry name" value="Helicase SWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="23">
        <location>
            <begin position="421"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="989"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="1523"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="141"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="539"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1787"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="809"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="920"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1795"/>
            <end position="1811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODO06429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1833" mass="204672" checksum="29C09E6CF7955861" modified="2017-01-18" version="1">MEVGTSASSAQESNLQPSSNGAVAPEVASATRSLRARPSSIDVPTPGSSTAPGAGRGLSKKNLDVINRSLDSTSVEARREQRIQEKEAELKDVVEEHDSAIREKFHLERFVTLLEGWNPEQAKLDNSQWKESKHNLLSLLPSQPAINGAPRAGPSCPRTSLPARTTRRKAHEQSEILANVVTPAPVAVTPSAKGKEKAVEPKTGESSPVKAGRTGRGKAVNPNGDMPPPPLPKGRRAGRRVTMGASVEPEPEEDVEVEEPVSNKGKRRGRMSLPDLPAAKKLKSGRNGIPANESASPAVETPTSERPSPSPFTPALPSLAHLPFPPPPQRPRKRLVGPRKVQYTEPSQIPPPPQHDGDISQILNSYIHINDTGAQPDLKSLESRAKKDGYLLARVTYLQRHGRLQRLLDEGVVSGPSASHAKIIRAPARQTDHHDTLLAHMVQVRNAILNEAKAKPVVCKKIAKMVQTYWERIEGREERERLAEEKERKRLMKETMKGLRKRWALAVKIIRAKFLEEQKQEQDRLGKVHLQNILQRSTGLLESQVRGPENEVSDESEEESDATDDVSAAEDSEEDEDGERSDPESSMPPTSIPPESEMADQSGDDGEDQEEEDDMDTEVASEGHLHLLVSEDAMTADDAVDALVDHSEEMTVPSSLGAGQDRTESIAFQSPNGGPTTADDAPAVNGRSSSASPSVTRRPSRRVRKSVLPLPSDPDPDANDVEFNVSTSDIDDQDAELDVEMEDGDDVDRNQGPDSEDEGLLADADIPIEELLKRYGYPAPAAAQAEQETASEPSKDDVENTTGEPKAETQVSQEAPNGTEPSESTSLGETHDGTASTPTQVEQADRDQSLTDATLPASLDQTTFESKRQRRKRELWSPDDVGPQRLLSGKRKKVEFITEDGTISTERLAEDVPEAVAGEGSEEESEEESEEESEEESEEESEEDSEEDEEEEEPKEPEINEHGAARITPPFLLRGTLRPYQQAGLEWLASLWENGMNGILADEMGLGKTIQTIALLGHLACSKGVWGQHLIIVPTSVILNWEMEFKKFLPGLKVLTYYGNQKERKEKRVGWNTENAWQVCITSYQIVLADQHIFRRKSWCYMILDEAHNIKNFRSQRWQTLLGFKAKKRLLLTGTPLQNNLMELWSLLYFLMPGGIGEDATSVVGFANHKDFMEWFSNPMDKAIETGEAMDEETLKTVAKLHTLLRPFILRRLKSEVETQLPGKFEHVVYCRLSKRQRFLYDEFMARASTREALTSGGYLGVMNTLMQLRKVCNHPDLFEVRPVRTSFAMESVVKGYEPSDILLRKRLLKEEDDRRVDVLALGFNVTHREDTSPWVAQTRQKLDASDLLPYAITPVKHGKPSIPPVKDTRTVEGWLKYQAWIKGEASQKRWESIRHINRQRCAEKPLYGNTFLQMLGNLPNFLIPSEYRIRREDTFADLTPPAANLITSLPQRAEALEPIIDRFAVIPPNAVARDLTTYALPGIEPISHPSLTDPSFDTLHRSTVKLQIAFPDASLLQFDCGKLQKLWEMLRDLKAGGHRVLIFTQMTRVLDILEMFLSYNGHRYLRLDGSTKIEDRQVLTERFNTDPRVFVFIASSRSGGVGINLTGADTVFFYDSDWNPSMDRQCMDRAHRIGQTRQVHIYRFVSSHTVEENMLRKAEQKRLLDKMVIQEGGFNNDWWGKVGWKDMFGEVPGVANASTGAEPTEESGIVDIDVEGTPTAEDVEHTRPRVGEERDLAKALAEVEDEEDVEAARMAQGEGELDLQEFEEGPKGTVKKVRVFEAEKRETPVAVEADGGEGMEEEEEFEDEPEGVETYMLKWVAEDWDFFISYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K072</accession>
    <name>A0A1E3K072_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_01688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034556.1">
        <property type="nucleotide sequence ID" value="XM_019173851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K072"/>
    <dbReference type="GeneID" id="30190901"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="667" mass="71288" checksum="AA22A7064A6ACE7F" modified="2017-01-18" version="1">MLSLSRSLRSSQAPLRSFARSTPLLANKRFNSGKVSGPVIGIDLGTTNSCVSIFEGGAPKVLENAEGARTTPSVVAFTKDGERLVGQPARRQAVVNGENTIFASKRLIGRKFKDAEVQNDIANVPFKIVAHTNGDAWVEARGEKYSPSQIGAFVVNKMKDTASAYLGKPVKHAVITVPAYFNDSQRQATKDAGSIAGLEVLRVINEPTAAALAYGLDKNDSAVIAVYDLGGGTFDISILEMQKGVFEVKSTNGDTHLGGEDFDIAIVNYILAEFKKETGIDVSSDRMAIQRIREAAEKAKCELSSAGSTDVSLPYITATAEGPQHINLNITRAKLETIVKPLVDRTVDPCKKALSDAGVKASEINDVILVGGMSRMPKVVETVKSVFGREPSKGVNPDEAVSIGASIQAGVLAGNVTDILLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADGQTAIQVKVYQGERELVRDNKLLGDFQLTGLPPAPKGVPQITIIFDIDADGIVNVSAMDKATNREQSMTIASSSGLSDNEIEQMVADSEKHAEADKARRLVIEEANKGESFVVDTEKSMAEFESQLDNAEREKVKKLLGELREIAAKGAAGDATVKADDIRQALDAAQQASLGLFQKVYEKRNAEGANQNTESSESSESTEGEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K1B4</accession>
    <name>A0A1E3K1B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034347.1">
        <property type="nucleotide sequence ID" value="XM_019173642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K1B4"/>
    <dbReference type="GeneID" id="30190692"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="320" mass="33353" checksum="3CB180766F331C9B" modified="2017-01-18" version="1">MSEDQDNQSGGPMWSKFFEGLPGAGGDDDTASIVSASERPDTPSRSHLGHGRGLSSMTSPISEIMPNDSASAVDDGASDIGGKRGGAASSVAPPLPVDDGTYVFKFKTPSGRTHRFQARYDSFDLLRDIVAGKLVSDPFFSASSAPEGTEVHLPDPNVFALHYNDDEGDLVTMTADGDVEDAVRIARNQKTDRVVLVVDGGKVWEAAAKDLGGEKAVEALKAAAVEEAPTPVVATPAAAVDPEEAALVAPTANPATEPTYTSEKSAHPVHASQYQDHGRTVRSSDGQELVAGFLPKDMVLPAAIGFLGVVILGVFIAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2F3</accession>
    <name>A0A1E3K2F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034650.1">
        <property type="nucleotide sequence ID" value="XM_019172924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2F3"/>
    <dbReference type="GeneID" id="30189965"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="58" mass="6086" checksum="CCBDD9D9FF17836B" modified="2017-01-18" version="1">MSDQQATGQQDGLDKGVDAALKKAGHGQNASTTEKISDGVRSVFKKATGKDVPIQDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2J8</accession>
    <name>A0A1E3K2J8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034706.1">
        <property type="nucleotide sequence ID" value="XM_019172980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2J8"/>
    <dbReference type="GeneID" id="30190021"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="151"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="381" mass="42532" checksum="79602210DC7DA7A2" modified="2017-01-18" version="1">MFGTPEGPWNISRKLENRLGPRLKVDAIVEINGPRAETALTSKRESFVHEAYNDTVVLPDIEEFKRRVEAGILKEPRAIFVATPPTFRGGLGSNNNLEVKINELFPNSAIFLEKPVATGLPAEQSVGEAKAVGAMLETQHNAPVSVGYVLRYLKAVQEMKRIIEENNLTVMATNARYVTAYELAIKTDWWDKSQMQGPIIEQGTHICDLSRYFGGEIEMETIAAHALEAHEKPGYLSKRNFDETVILDANRIPRATAASWKYESGAVGTLLHATALHGKDYAIELEVYADGYQLILSDPYGTPALHIRKPGSDAIEIHPTPGDDPYQAEIDTFIDTVEKGNPAIKILSSYKDAAKTYEMTWAVRKSSEESTRRLDRKYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2U4</accession>
    <name>A0A1E3K2U4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034813.1">
        <property type="nucleotide sequence ID" value="XM_019173087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2U4"/>
    <dbReference type="GeneID" id="30190128"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="344" mass="38301" checksum="C3B84D3B44633CF7" modified="2017-01-18" version="1">MDTSPDGEWLYKATWYEAINDPEYMKEHPELESLEPFIPAYKGWVERSSYVRSETPASSRRGSNVSSSHKLGDMVPKYGKDGQIVGYKPNGADKYTKSIIISNRTHGLRDVTVADFKLGTRLYGPLASPEKRARQDATTAESTSGSKGVLYAGGTTWLPSRECHVFSDDRFSRTLNDDTLASAAACVFPSIRDLALPSEYVVAQEDEQPDLDLEECREKEQDMLNRTRTALQLLPKLSEAIQTTGLDFPGTSALIIHGKSVEDDTPEVRLAFVDFAHTHQHDEDMSPDGVLFGIQSTMGILREQEAALERSLAALDNDRKPWNAWGSDAEEEEGEGWNAWCSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2V7</accession>
    <name>A0A1E3K2V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S small subunit ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034836.1">
        <property type="nucleotide sequence ID" value="XM_019173110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2V7"/>
    <dbReference type="GeneID" id="30190151"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO07359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="129" mass="14240" checksum="8D3C27CC23BBB4D5" modified="2017-01-18" version="1">MPYQPNHIFKGVVTKVGVMRKTATVTVERTFEHPKILKEVKRHKKYLAHDEGEVSRLGDKVTIIHGTRTSKSKSFRLHSILSRDTHKFPNDPIPSVIPPPALSGRQIRKAAAAEGGSGKVVEALKEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K379</accession>
    <name>A0A1E3K379_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034966.1">
        <property type="nucleotide sequence ID" value="XM_019173240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K379"/>
    <dbReference type="GeneID" id="30190281"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="976" mass="104970" checksum="D18D310B4356030B" modified="2017-01-18" version="1">MEHTNAEASSSKHPAPSHPRNNLSLSLSLTVPRDNSPRGSRGRSASRRRDARNEPASARGSAVDLVLPQSAVSAGTARSGGGSLRVSERALSPKSGSEAGGSNASRRLRTVPPMAIFEPPTPPPSEQPLPPAEGQSPSAAADPFPTITTASSRAMRYRYSDSSSNQSSADDSSFDETPPWWTFTQRGMARIKHRTLKHKQGQSGKESDREDEGGLTEGVTEAESGREEGRPKKRTSYFSASRKSSKDTPGPSGRRTASPSRILGYNRNSAYRADSVNNTTPSLKLSNAFKKGSTTRLQPVATHLRPIKSNHGNESQTFGRRKPPLKRMDSAPAATSSPTSPVFPSSPSPGLATLVDQPLRDPQAPIVLGGEVSGASPTASPTRRTARRQLTAPAFPRFFRSRDTGTGDEQSEETDHELSPLARPRPRSTLTSTSIPDPAQTNFNLTPGQDPNDPSNSPGALKYKRKGSNRLRINLPPPLTQHFANNFQNGWPHAGSWQDALYGYYEEPQKMRQGSTPAGGFAFGVTEEGAAGAGTASEGEGGSRKKKKKKERRMSSKAPGIQSIPPSPHEGDIESSAEQQPPVTAGGSKRTKAKKQKRFEAMVPPTPSGLGFTPRHSGEGLGEYPWNGMNGENDRMNGSGEKAGNEANEETLRADQPRGNTLALLHPDPAHLRNNANLARHTSRATITDTTVDGHDSNSSAFGYSRGGRNGFRLFGKRQRPNEKRMDLNLSWKKRWKRVLFLDARVTIWVRLINLIVVVIALGLSIQIRLNLISLSLPGVLGSSTTLIISYATTTIFHGLMAIYREYFGKPIGLWGLSSKMLWVCLDLLFVALWSSALSLSINDLIATPLECSAGAAWWRNGLASDYASLIAELEESAEAVANATLGDNSSSATTAISDNLLGVTSPDLISTSLGITLPTSITASHLARQVCRHQAACIALSVLALLLYGGNMVLSLFRIFETVRRTGNASRAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K391</accession>
    <name>A0A1E3K391_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034890.1">
        <property type="nucleotide sequence ID" value="XM_019173164.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30190205"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="966"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="441"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="789"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1159"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO07413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1396" mass="150404" checksum="8D41D0D33B09D0FF" modified="2017-01-18" version="1">MSTPSSVNTEYLSSSSPTPTIRNNATPARPPTSSQVFASAVGVSPGHTPGGTPSQHTEQRRTHSGQQQQQELGKGRPSRNELPPPAASPSTGRPALSPARASYSSADDEDYLGPHSYPHTAGPGNTSFESTPRGWSSARGRPQQTALGSSFGSPTTLFNPAARENPGGSNRLGRGSRFNSAREVSQTTGGGTGSRSASRARPPLFHHHSSSRERSEIQNGEEEDVDRGAELIKQRQKERRAKKKRQQQEVEGRRLAEEGTTPETSNPPTGVPGQGFKAQQGTLHRAPSSRVREVSSTRKLAGDGDYFPYPGSVSGTETPRDGRFSPRDDLRPASIYSSVADEDEDEFDERASLVGDIVNDVIGVETGDRECNSDEDDEEEIETDEGVTLRDRQDAINIEHPFGLPIWKPALYRKSRSVTRNAESALHSIPSAAAERHLLPGNIIWTVVFGWWLTLICLFVALLVSGAEVAGGGRGGYGKTLRGLAWYIGWPFGKYVEGEGGPVDDEHTEGDGDNEDAEQGNGQYGAVNGSGSPVSKRAQRREVSGASSGITVKDTQRPDMDGTSSPDAPSTSTVRAEPAVSFAPNVKGKDKDNGERTALLGGGSFRRPRNKKAKRLGMLVYWPTFLLVIVPVMLFVCVLCWCFVVTIPMAKLTWKLLNLLYTRPLEINFRAAPKVPVPTPHPSSDNVTEESDPLADESPAFTLRRARLHAGQVAPTSGPTSTVLLCTYRAVGLQYYKYTVGGVNILFINLLPLVFFTIIDGMLLLPFVEHQEHIGKPITPLLRFLTSQALIFVLALASVIPLSYFIGMAVASISAQSSIGMGAVINATFGSIIEIILYSIALMQGKGRLVEGSIIGSILAGVLLMPGASMCSGALKKKEQKFNAKSAGVTSTMLIMAIIGTLTPTMFYQTYGSFELHCEGCPAPTNGTTGHTTLMKPEDVWMCNHCYYEHPDPELDPFYQENVKTLMYGCAAILLFSYLIGLWFSLRTHATQIWQNPQQLLKPEEHQALGVHPAVKATLTQRLTPQALAQHLLPLHQQQKPPHTASPVIPVSTTDGQPIPATASPKGGTLRLDPSGFPKDDDGQPSAGPYTVPGTVKSVPNNNPAFTLPAGYTPYLEGLDQAAKQNNLTPMRLPGTLTTEDFTRAVAVATVSALRHQGSIVGSERKHRHGEGGGVAVNEAAPGAHVGNGAGDEEEGGGHEAPSWTRGVSAGVLLGCTLLYAIIAEILVDVVDVVMQGSGIDEKFLGLTLFALVPNTTEFMNAMSFALNGNIALSMEIGSAYALQVCLLQIPAMVAFSALYKPDKMGDVIDTFTLIFPRWDVIAIILSIFLLTYTYIEARSNYHRGSILVLAYVVLIMGFYYAPVRETDDPTRDEVLTVDALKVAGSLGMEMTKLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T6</accession>
    <name>A0A1E3K5T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035394.1">
        <property type="nucleotide sequence ID" value="XM_019172452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T6"/>
    <dbReference type="GeneID" id="30189482"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="34994" checksum="F1B6D3C03D656187" modified="2017-01-18" version="1">MSAVHSAVREPDFCKQMLTLLPVKITAVTHHIPYFLRIPAEALIGEQCYSTLVYDFDITDVDCLKYSLSKGLGFGIVVGGGIIKIPQIVTIVSTRSAKGLSLSAYALETVAYAINLAYNSRNNFPFSTYGENFFLTIQNVIITLLVVYFAPQRGAVIGANPLTSKKNPNGGKVFTGIVITIATGLALWSEQLCPLTFLSLLQAATLPLSIISKAPQIIQNHKSRSTGNLSAFAVFNGLLGCVARLFTTKQEVNDPLIFWGFAAAAAMNAILALQVFIYRKSDDEILEDRRHSASERGDHVVLEKPVVLEGGNGKRWARKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5T9</accession>
    <name>A0A1E3K5T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035059.1">
        <property type="nucleotide sequence ID" value="XM_019173333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5T9"/>
    <dbReference type="GeneID" id="30190375"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="132" mass="14418" checksum="3044211D1C29CA0F" modified="2017-01-18" version="1">MSSEAPSNFTIRPALPSDAPAEGGPSGKDVVRLSILKSGVSTPGVSMPSAIKLRRFYVHSSLHGSGLAQRLLEETEQTVKDTGEHEGSWLHVRSENGRAVRFWDKEGFKRVGEESWVVGDSQLELITMEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5W2</accession>
    <name>A0A1E3K5W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035262.1">
        <property type="nucleotide sequence ID" value="XM_019172320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5W2"/>
    <dbReference type="GeneID" id="30189349"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="488"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="726"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="804" mass="89937" checksum="CDC580187F9F2700" modified="2017-01-18" version="1">MSKPASKAASQKPYGRPQKVVNKTVDLLKKNERASAAGKGKERQVLGDVMGLVDEVKRLPNLIQVEKFAQTRAMEIHAFQTAIKSAATQGNTRAFQSLPRHLRRRAASHNPRRVPKRLRSRAAAEIDAADNIAKKHRKIAKLRAKGNLRSHLSRTALFRIRQRSKRWLPTHIWHAKRHHMVNHWGWRLPMSPTLKSFRPAYRAGRRKAVAWDVSYYGVIELEGWREDIIRLLGGVTDGKFAGDMFESGARVASISFYQYDAFPQGLIGPGEVFWQPTTHAKNGRTVWIRLHPSIFNHVWTLFKTTSLHILSEAGSSSSASQGLQIRDLRDQLEALEIMGPKSGEVLRRVLRLCKSEETLKQRVFNGLQDPSNIPDGTVIGLQAYDPRLHFPPPKLSEAEQSGTNDGVLRDDIIEPTMELAFSLLWDAESRENASEVTYTKFQLDARRHKLGLPGTRLHPRQSDDRLPIMLFKRSTHPPPSTTPQSFHGFTLILPTSWAQYLLTSIAYTGTLIGGLNERKVQHREAGVHSFPEYFSGVCEAGDRWHEGKAAFEKETWDRKPPGKRVEFAKVGTSSPWTPDWDKLLVSVYLNSGMLVADYSQSGDTSAEEASLNTSSPCKPYLLPHPFSTYISSSLTPLQLLKQLNTFRRQRSLSALPPTKAEALFNETVLHVEIDVLGRGSPGDMAMICGLVGEEREKWIQAYEREDDGFNFAGEVTELQKLGQAPSSHQRLIGYTDSGNISLTRGQGHALGTITLRGYVELLQAAYPSAAGQKGHVKGWEGKALVCVKNRDGIVGRFGEVRVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6D5</accession>
    <name>A0A1E3K6D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_00226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035353.1">
        <property type="nucleotide sequence ID" value="XM_019172411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6D5"/>
    <dbReference type="GeneID" id="30189441"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130787" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODO08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="224" mass="25073" checksum="51B49F9E1357DD4E" modified="2017-01-18" version="1">MALLPRSTLAALYLLLLAACSVSATALTAMLGANERSCYYADVDGLGEKVGKSCFYFAVQSGGNFEIDYIVMDPDDKVILEGVAEKQGDYIFTANKLGEFSFCFENEAYTQDKLLDFEQVSFSSLIMVESEPRRILSGQQPPLKEHTSALEESTYKISGVLNSIARTQKYFHTRHHRNFSTVKSTQGRILWLTILECIIVVGMAAAQVWVLKTFFSRGSRRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6K2</accession>
    <name>A0A1E3K6K2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_00503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035625.1">
        <property type="nucleotide sequence ID" value="XM_019172683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6K2"/>
    <dbReference type="GeneID" id="30189716"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODO08770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64956" checksum="3CB85C42CC3D8041" modified="2017-01-18" version="1">MTADYTSSVSQLYPHSSLPNQSRKHNISLDRLPLHIVSQVAFYVLVDDAGDAGHPAGLLPLLFSCKRVYQALYIKYNVSLYGELYKATFDYQALLRRYAWHRGNALRKEAGRANDIFQDSRLWAADYKDRWEMSRRLRMATGADTLEIPGVCDISMHNQDVWNIWNLWRRANQHSDGKNMLFLVHHCHLKGALELMYRDIVLPEAARPGFPVETGAKGIMAWLLVLSHFDSFKEDDQEEVDQKMFILRPYSVAAGIYYSSYAPYTVKKLPLQDYPSEAQAFAVVPHKDYTSTYHRFNTTWSRQPPQCILASEIGFFRLLERRSWQTSTGKGFTKEDSYSFEKGFPGILATPDASTLTSEAYDREWKRQASCQDPMNGPGLLPLTFKGCIEGTWRGKSLYMDFDTYRRILGGDVRLAFAGPYQSQAVEFVLREGLIKVRKGMVGGYGHVFHAGMINGDSLERELEWVANGCGHEFVSEDTIDEEGWTKEIIITGHGRTAWGVASIRGRVRSWDGFVLLSLSYAQDPGARWLWSGYVVPGGYLAGRWRDTVIPANQAGYEGAFVCIREDAMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6X7</accession>
    <name>A0A1E3K6X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035694.1">
        <property type="nucleotide sequence ID" value="XM_019172752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6X7"/>
    <dbReference type="GeneID" id="30189785"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="95"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="389" mass="42500" checksum="F631BBC2DBEF6607" modified="2017-01-18" version="1">MAGGLEKRRLGAAASTPASWRRRSEGLVSSLRETCKPEGITTFFKRAVFSSVQNLMSLSSRLPRLVSRSPSRSVLLNSQPPKTYTKMEDGQKVLVGCIGGSGLYNLDNLTPVKTLDITTPWGKPSSPVTISSLPTGELIAFISRHGTAHTITPTEVPARANIAALKHIGVEAIIAFSAVGSLREEIAPGDFVIPNQIIDRTKGIREDTFFRGEGLVVHSMFGEPFSEKLNAFVAPRVDKILKAQGEIKLHTEKTVVCMEGPAFSTRAESLMYRQWGGDIINMSVIPEAKLARECELDYTLICTSTDFDAWRTGHDPVTVEEVVKTLHTNAGNSRAVAAGILQEVHALVSERKVLTDIKGSMKFACVTRADVQPVESRKKLSYILPYFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K733</accession>
    <name>A0A1E3K733_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035660.1">
        <property type="nucleotide sequence ID" value="XM_019172718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189751"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="763"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1444" mass="161367" checksum="5F63075DDAB1CEAA" modified="2017-01-18" version="1">MTQHPPDTPERSATLPSDLTPPSHPHGPRNPDHPGSSRTRYHTTPLPQHQGSPSQPISVLDSSESSPDLQPVDVGEPEPEAVYRPPEPVVDLTDEQPPPYSPGIVADPVDAGIEMDIDNKNSVKDISDWQAGLGQYNLMDVDQPSLRSKPQLGPGVLPRRLLAIIHEHELVRPYIDELPEPAKRIQEGLESPDVRIAMSEDVYNALPGGGQDHDHWYFCTTCWSWLRIIEGRDETFPQIPSMEEWEVWAVENKIYDEQEKFEAARKERQYQLDQLLLCREAGRTAGEPHEHFHEFRNIVPSLKMSRIERLDVEEHQNLFPHVTFGLERDEKLESFSVPHAPARLYVSDSSTSWIFVDEGMVPGQIPAGLVQAFTAEKMSNPAPGKTGYKSVSDAWDLLATLLSNALFKGKRGAVSLANQRVQNCIGQGILSSHVLYHSGFACTEDDDSLRVGPYRGREDDLVPAGQLGTMDRYMLRVWVEMSLYLKAYQIRNSIIETCHCCAVEPVRLEFSLESYLPFQKYQEARPSLPDALKNACHALGATRFDTVDTLELAYDLQIAFDEVNTPKYLGALETISEGPIYGKDSAQLKVAMEKSMDKFTESESTWYNDLLRAYSLIGYTTDHAETICVAPHEAPTDYLLDMHKKAIQACTSPSARQDVNDALAKIGKARESFMLQSMAEKGQTTVSVQEAYEALSAPRDAVDDGLIMQYEMAVNEYPGKADHYRMCLSVIADAPGEERPGLKTFLQTGNRDPGAPARKDIPVGLQNIGNTCYLNSILQYLYSIKPLREAVLEFDQDENNMATPVKPEVERARRFVRQLRLLFLQLYKSELPAVRPEEELAYLAITRPEVDSWVDSEEQPVQISVSASAETAKGEPTGSALDSIPSIPDLADVPSSPTSTLFASAPGSPLKETPLELAEPSSIQSDQSHKDDGGRSPETSSSRRSTSSSVLGKRAINERERSFSPGEERNRLKSAERSMSGIMDEEDKEDENVTPSKGKRELVESPTMTAEMSHLELQTPAKDGGETETDEVEAMAVAEDERFAPPSVPPPSLPPRPPVAKKETLSSGLKFGLQQDSAEVLINILTQLEMALERQAEEGEEKPNLIKELYSCSFHQQTIYESALPTPGGSTAYEAAKDTEAVFTHPIIGVEEEGKDLDDCLAELYLKGADIEYEGKKGYMMELMDQFPPMLYIQMRRSQYDPVLKRERKTNTHIQFPQTLSMSRYLVNAPAEKRAESIDLTREMVRIRTRLHALQNHQPLSIPDTFKHASSALRYLASADVTQEIPELEGVLEDDLFDHLDAERLETGKEIEELQAALPDLKARMNEIWAAKDGEAMDQGDEYEYELVSVYMHRGKTSGSGHYWTYQSHLPGHSEEFYSYNDELVTVVPAAEVLQDRTGSDANPALLCYARKGWNLVETLHREVLEQEAGDVAPEQDLLLNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K764</accession>
    <name>A0A1E3K764_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_00102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035234.1">
        <property type="nucleotide sequence ID" value="XM_019172292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K764"/>
    <dbReference type="GeneID" id="30189317"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="305"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODO08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="423" mass="45547" checksum="200E1F1F039AA132" modified="2017-01-18" version="1">MSTSTPLSFYSLPDKGQLQKAFVGKPLSALRTPALIVDRKVFKENCERVTGEANARGMAFRAHVKTHKTTEGTRMQVEAAGGVKAVIASTMVEVWQVVQSGLVEEGLVDDILYSMPIGADKLEDITSAQDAMVGKGVIRIMVDHAQQIQFLQAYNRRLASEGKERGKWSVFVKVDGGGRRAGAPPESEQMKDLLAAILAAPEAISIFGFYSHFGQSYASSSLAAGSSFFHAEIACTQTAAKLARSLGALGDWVISVGATPTAHAAVQEAVTDLKVDGKLELHAGCYCMNDLQQLSTSLPSPSHLALSVLSRVVSLYPAEDRREAMCDTGALAVSKDTGRQPGYGRVIWPKKAEGWDLGRVSQEHGTLLRREGGGGGEGELEIGDLIRILPQHACLVCACFPWMYVVDDGGKEVVDVWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7F6</accession>
    <name>A0A1E3K7F6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035711.1">
        <property type="nucleotide sequence ID" value="XM_019172769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7F6"/>
    <dbReference type="GeneID" id="30189803"/>
    <dbReference type="OrthoDB" id="3361363at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="49229" checksum="FB5350A7A2980DB6" modified="2017-01-18" version="1">MGDQPPALPPTPASGQTTFDARLAYIQSSSSQVPTRQNSYNYPTHLNPSHARTQGPSQGPSRRPSLEGRPGHATHPSMSNAPLLNGNAPSALAHPGCVLCGLVRSCGSNPPSPILSPQHDTSFMASSSQTPTTAGSFSQSPYPLPFDRGGASSPSPDGRRTGNRVGGRDIVYGDKDITIYKAEGKERLCQDGRHLIIVVNEHLQSVYEFGASDIPLLSHIIDTAVQILNSAASASLDDEERGKEKDKVQVGFVGSLMKDPQSPYAHLHAHAYLPPIDTKLAGSTLWRRNVVFGSLNWWSVEDLRAEIREATSNNRVKTGYQHREAPINQVPDAGSTVRSWSTLYDGTVLTTKQAPIYSNESDYHDAPSPLLAPGPLHRPPSRSQSRSPGASSSKSPPPRPSSYPMTNMAGGSDVSSRTVTPSSARGSGDVRRHGKGKASEDFENVEMEDSRRSREGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K8Q8</accession>
    <name>A0A1E3K8Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035762.1">
        <property type="nucleotide sequence ID" value="XM_019172820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K8Q8"/>
    <dbReference type="GeneID" id="30189859"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="268" mass="29127" checksum="AD2130F06D47A1CE" modified="2017-01-18" version="1">MSLSDIAESPSAPLDETPTPSTASDEAIFLHIPRPLLVLPSVALSFGLSIGFVRGGSKARLRFLAENAHRMPKTVGGWYFYTKTRNYRVIQGALKSGGRYGAALGGSTLTYVLLDESLGWAREQIFGVKIGEGGQEEREQIRREIVEGRRIGWRKGEVEWEDGAGAGGLMGLVVGLGFKLPRPLFIRSLVMGSVLGALTSSMQVAQHRIGRLRLEEERLSSLAKANEQESALLAVEETSPGTELSPESIKESSIVEDKSWWSSLTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HSF1</accession>
    <name>A0A1E3HSF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028108.1">
        <property type="nucleotide sequence ID" value="XM_019179932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HSF1"/>
    <dbReference type="GeneID" id="30197170"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="305" mass="32855" checksum="5CEEAF51E960249D" modified="2017-01-18" version="1">MSEQTSVSPCCVTGHIHAGTPIGSTSILHSLRTYTSLPSSPAPSSAGEGKQDTVIFISDIFGIDLVNTKLLADEWAGKGWKVLLPDFFEGDAVPDSLLQAIAPNARYQAESTTTSKTADGAKAGATMGPWLAKHREAVSKPLIEKYVQAVRSDPSTGKIALVGFCWGARYAFLLSQSTSPARPDVIIANHPSFLTVDDVKPVKGVPVQVTKGDEDGIMSEEELDEVEKVLTENLGQNVLVKRFPGAVHGFTVRGDMEDGQEKGQKEDAQVSPEPKRQADSDPSFKINTEFVQKYFAQVPSRAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HUA8</accession>
    <name>A0A1E3HUA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000047">
        <property type="protein sequence ID" value="ODN79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028094.1">
        <property type="nucleotide sequence ID" value="XM_019179918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HUA8"/>
    <dbReference type="GeneID" id="30197151"/>
    <dbReference type="OrthoDB" id="5552562at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19175" checksum="9F633FF9C5D56095" modified="2017-01-18" version="1">MTRRRGALHAPSQEQEVSGLTAGPGTPFTPAADIPLPPSSPILENSPRHEGTIQGPEPLNRQNLGTDDVDDKPPAPAFAPPPAPASPVPPTVVYSSSPAPVLAPEPTTTRGHRVKVAKEPEPFSGNRSNLEYIISNNRLYFDTYPCSFVSDKKKITYMLTNICGPVWAALQPYVNQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HY82</accession>
    <name>A0A1E3HY82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000042">
        <property type="protein sequence ID" value="ODN81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028235.1">
        <property type="nucleotide sequence ID" value="XM_019179754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HY82"/>
    <dbReference type="GeneID" id="30196977"/>
    <dbReference type="OrthoDB" id="2577583at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022235">
        <property type="entry name" value="DUF3760"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12586">
        <property type="entry name" value="DUF3760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="230" mass="25654" checksum="AAE0B94E60A4DE41" modified="2017-01-18" version="1">MLPAPRAPLSSTPVPNWCPDHSGRPDANAQGLSREMTTKTRADFAFIIDNKEGSDVTPTFEALHVSNHSHHSPTAGYPITLRKKKEIKTGAYESEAGVFRRICQPSAAVETLEALHPVHHRILDELFRLKPLVVVTLSKYCYDFFLPRLYKKVYLNAHSLPATVESFLHGLSTSNGRKEEAFKHIRDICFYFPPLVYVPKGNKLPDGTRQMIPIARLKGLSPAPELTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I551</accession>
    <name>A0A1E3I551_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000039">
        <property type="protein sequence ID" value="ODN83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028365.1">
        <property type="nucleotide sequence ID" value="XM_019179677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I551"/>
    <dbReference type="GeneID" id="30196900"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="259" mass="28016" checksum="1C7E0B279D92AFE4" modified="2017-01-18" version="1">MTSIGTGYDLSVSTYSPDGRLFQVEYAGKAVEAAGVAVGLRCKDGILLATERILHSKLLVKGANRRIASVDEHIGMAGAGLLADGKYLASRARDESGNFRETYGRGISVKILADRLSAFLQAYTSYGSVRPFGLSALIAGVDTASKTPLPQLYCVEPSGVYYGYKATAVGKGKALAKTELEKIVKREEEGEAISVKEGIDELARIVYLVHDENKDKDFELEMTWVCAESGWKHALVPEDLLKTAEEKAKAALEEGMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IB63</accession>
    <name>A0A1E3IB63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028516.1">
        <property type="nucleotide sequence ID" value="XM_019179478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IB63"/>
    <dbReference type="GeneID" id="30196695"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="382" mass="41124" checksum="E9DD3482D40FCD76" modified="2017-01-18" version="1">MSDTEDACAIDNSDTHHRLRIGAIFIILVTSLIGTLLPIVLRRSSLVPRPVFDFAKYFGSGVIIATAFIHLLAPAWDELTSECLSGAWQDYDWAPAICMAAVYFIFFAEVAAYRLGSARLERLGVEYSSHTHDETDAHAHDHAHDPPLDVDTTVPAPAHHIHPTNSRVTSGDHGHSHSYSHSHSHSHSHSHGPLSEKEKDLESASSSETDSVNQLPSPAEAAAQLIAVAVLEFGVVLHSVIIGLTLAVDEAFITLFVVIIFHQMFEGLGLGSRLAVLSLPDKLSWARYAAAVFYSICTPIGVAIGLGVRSTYNGNGAKANIISGVLDATSAGILLYTGLVELIAHEVLLNPRMMKSSTGKLTYIFCCMLLGSGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBV2</accession>
    <name>A0A1E3IBV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS transporter, SP family, general alpha glucoside:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000033">
        <property type="protein sequence ID" value="ODN86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028612.1">
        <property type="nucleotide sequence ID" value="XM_019179364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBV2"/>
    <dbReference type="GeneID" id="30196573"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="73"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="544" mass="59938" checksum="563850359D8CE930" modified="2017-01-18" version="1">MSGQIVQTTPYNDTAKAEGDVPYNDTAKAEGDVEHIEKAGGVDYKAGAMEAENAEHAMTVLEAVRAYPMACFWAFIMSFCIVMEAYDVFLIGNFIAMSEFKTRYGIMDSTGAYVIATKWQSALQMSGQLGALIGVFLAGPLTSRIGYRWATFSGLMVLNGFIFIMFFGDSLPVFFAAQLLEGIPWGIFIANAPAYCSEIVPLRLRAPCTQMLQMFWAIGAIIVGAVTYVYNKRMDTMAHKLPIALQWLFPTPLAILIFLAPESPWWLVRKGHYDRAARSIERLGTKAKLNAAESVAMMRRVVEMEQSATAPSYIELFRGSDFRRTLIVCFVYAAQNLTGNLIANQAVYFFEQAGMTTDTAFALGLITSALQMVFVMASWVLTTYFGRRTLYLWGSAVNTILLIALGIAGSIGSSHSAQYAQASLGLIISVLFTFAVAPVSWVYIGETSAIRLRPLTTGIGRASYYIIEIPCIFLASYMLNPTGGNLGGKCGYVWGATGLICFVIAFFCLPEMKGRSYREIDLLFRRGTSTRKFKTTEIGVDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE00</accession>
    <name>A0A1E3IE00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_07179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028809.1">
        <property type="nucleotide sequence ID" value="XM_019179192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE00"/>
    <dbReference type="GeneID" id="30196390"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="157"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="410"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="543" mass="59411" checksum="0D317A8512282D1A" modified="2017-01-18" version="1">MSLPAGITLAQHVPPGAEHILTHDALQFLAVLHRTFNTTRLQLLANRESIQKDLDAGKPLTFLPETREVRENTAWACAPPAPGLEDRRQITGPTDRKMVVNALNSGSKTFMADFEDSNSPTWSNMVLGQVNLYDAIRRQIDFEQNGKPYKLSENPAVLIVRPRGWHLPEPRLLIDGTPISGSLFDFGLYFYHNAAELVSRGFGPYFYLPKMEHHLEARLWNDVISFAESQVGGGKVGGKTRATVLIETLPAAFQMEEILYELKEHSSGLNCGRWDYIFSFIKKQRAHKGAVFPDRSDITMTVPFMDAYVRLLIQTCHKRKVAAMGGMSAQIPIKNDPAANDAALAKVRADKLREVTAGHDGTWVAHPALVPIALDIFDAHMPSPNQLHVLRQDVRVTDKELQDPSVPGKVTDKGVGDNVEAALSYCAAWVGGNGCVPINWLMEDAATAEIARVQLWQWVKYGAETAEGTKITPAHIQSLLSTSSATVSKLPGIDPLHVKVAAAYMAGQIKQEWPSDFLTGDLMGVLDGEELGAGEGGGGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFM5</accession>
    <name>A0A1E3IFM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028957.1">
        <property type="nucleotide sequence ID" value="XM_019179039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFM5"/>
    <dbReference type="GeneID" id="30196232"/>
    <dbReference type="OrthoDB" id="2596769at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="201" mass="21803" checksum="5FE317ABC3ABCFC1" modified="2017-01-18" version="1">MVSSQPFPEERIHINVRFHPPPSCHSSHPADHNRTRQPRSPPPSSKPQHVHAHHNPRTMLTRPELPPRSELPSDHPKNPNSRVRLPERPHLSQYWHDAYPPAPLDDDTVLPKPPSKIKYMNTEWQKNNPNPKSRDAVKAYYGGGGMYPGMGVGGMYPGMGGMMGGMGGMGGMGGMGMGGMGMGYGGMGMGGYGMPRYGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGD1</accession>
    <name>A0A1E3IGD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028793.1">
        <property type="nucleotide sequence ID" value="XM_019179176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGD1"/>
    <dbReference type="GeneID" id="30196374"/>
    <dbReference type="OrthoDB" id="2576184at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="205" mass="23110" checksum="4C339A2C61B2AFD3" modified="2017-01-18" version="1">MRLAKIFTKKHDKTEATFDDVTLAFYDAGRSLMDTRKTVKALEIERATLLHSMAAVTGLEYKSLRSDFLETRKEEGFVRGDNKISNAELLGEWMNSSAEERSTWDHQPWENMRSRLELEGQQTSRASEIVQADNDILRSALDAITTYRDRSAHMSYNRQDKALRRVSQIQGHMTSQRGEASGSASSSAGESADNSGSPSWWSNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IGJ4</accession>
    <name>A0A1E3IGJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000027">
        <property type="protein sequence ID" value="ODN87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029053.1">
        <property type="nucleotide sequence ID" value="XM_019178959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IGJ4"/>
    <dbReference type="GeneID" id="30196147"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129750" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="438" mass="46065" checksum="0786F798EAA08129" modified="2017-01-18" version="1">MQLTALIPVLALLATPALARSSLHPQAAAHRRAVGQHERIAGAVEQRRDELAAANPRALAEKPKVQKRRKVVRRGTTCRVKDSSASATVSETASATSTAAETYAASAVSDVESSSDAAVPTDSAVESATESATESATSVESPAAAETASTTAAASSSVAAVAAYEVSSDSSTSASSTSSASTSTSTSAYTPNNIKAGIAGGDAYSMIGDHIGWWYDWNAVPSGHTGSAAIGVNMLWGAGTVDDTDASRLAAFQGITDTPAYIIGFEEPDCSTDGSSNIAVADAVTVWENNIAQWKGKGSLLLSPSMCHQAAEEYIGWLSSFESQISTDFDILNLHINKNNMDGVKADIDYYYNNFGQKPIWVTEFACVDDSTDFVPCTDQSEINTFIQDIVDLFQADDRIYAYAYSTGEGLSDEWALVSNGVLTESGQTYTTALAKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIQ0</accession>
    <name>A0A1E3IIQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029296.1">
        <property type="nucleotide sequence ID" value="XM_019178813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIQ0"/>
    <dbReference type="GeneID" id="30195971"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="157"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="640" mass="71514" checksum="D6DC02B7B43FB60C" modified="2017-01-18" version="1">MPPHSQLRRRVQNQPTAAGVIPYERHPPARIPSTRGYHLAISIFIVGAIILYAQKQTNLVRNAFPPRRYTALGEEGGDLPDLYAICSKQNGKSVLTVPFDYEGDGDEEGVGRADCVVVIDGEVVDAGGLKKMRRKWVTDTYPKPISEAMRIIDIPPGRTVTPGFIDSHGHPLVYGHSRQLQLHGSRSVAEVIEKVEAFVLAHPEEVKEGKWIQGLGWDQNLWDDKEFPTASDLDKSDILRGLPISLSRVDFHVEWVSSAILTRLGKVRDVSGGTVVRDEKGKPTGVFIDNAINQLAAIRPAWTDDDRERFLNVMLKDALKGGLTGVHDAQGFEKDQKFWRKMAKQGKLPIRFYNMLSCEGRDYCGDDIKPYDDFDNHYTLRAVKLFGDGALGSRGAALIDDYTDKPGWKGMMLKDENIWNDLIKKWYNAVTNIWQNVHTIGDRAGKVVLDAIAGSTNDPVARRDARFRLEHSQILTQEDIKRAAYMGVIASVQPTHATSDMWYAEDRLGPERIKGAYAWRSYLNESGIITLGSDFPVESIDPLHTFYAAVTRLSVDGTSPHGKEGWYKEQKLERWEALRGLTVGGAFASFSEDRIGSLTEGKRFDAVVWDRDLLTVPEDEILDAKVKAVIVDGQLVYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IIQ7</accession>
    <name>A0A1E3IIQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029291.1">
        <property type="nucleotide sequence ID" value="XM_019178808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IIQ7"/>
    <dbReference type="GeneID" id="30195966"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="231"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="714" mass="78505" checksum="CAA345CFAB6A9DDC" modified="2017-01-18" version="1">MPRNNAPLQPLPLQHLLQTYTTSHPLRSPSPLPPSSRIDPKLEQRLPPPASSSPFLWSLAEWWLFIRFVFTKGIHVLMALLSHLLFGPKRTSWGYRMTLITSFMRNIADHSSLADIVLIRRFVSLHFLMPLPGDAVVTPITFVVPKRTEAQAARGFLRQCDLLELGDRELAGEWVVGTEVWKRLKAEKRARQRHRQGKGKGRSASPRAGQRFPELATELKNEAGAGERVIYYIHGGAYYVGNAATHRLITIGVSKSCNARVFAITYRLAPEHAFPLPLHDVLHGYLRLLSAPLSIPPENIIIAGDSAGGGLSLALCMYLRDEGYKLPAGLILMSPWVDLTMSCGSWDENASSDVVPRPEADDHLNPVGCYLGPKGISTYLTHPYASPLFGDFHGLPPMLIQSGDSEVLRDEIILVAHKATLAGVSVTHELYEDMVHVFQMFSFLPATEKAIYNVGKWVRTVLPGIEREKREAEGRVGESGVGGLHLDVIESVEEEIAEEGAHVIMNNGEEIGVNKPEDSSERARRTPKKSTLRYETQEAVDDEPTVDTDSLATSDSGSPTPTKNHKGSGYPFPRVPATPTRQDPIVPQAHTLPRLRRTQTSVPAFTLSPPPVPSTFSRRHRPTASTSSSTYYPSPSSSRNPSQPTSPSSGRKRLMSGTLSYQPQPSTRTRSKSHSDVFSLVEGYVEGGAANQTTVYAPGGEIRSVGVLGEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJ02</accession>
    <name>A0A1E3IJ02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000025">
        <property type="protein sequence ID" value="ODN88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029234.1">
        <property type="nucleotide sequence ID" value="XM_019178751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJ02"/>
    <dbReference type="GeneID" id="30195908"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="181" mass="20620" checksum="27CA97A1DC0BCBDF" modified="2017-01-18" version="1">MRPLTEEETKSVFEKLANYIGKNLVHLIDRDEDDEYCFRLHKDRVYYLPLPMLHFATSVARPNLVSLGTCFGKFSKTGKFKLGIASLDYLAKYAKYKVWIKPSGELPFLYGNHVAKAHLGRITEDTPEHQGVIVYNMSDVPLGFGVTARSTLDTRKLDPTGIIVFHQADVGEFLRDEDTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJR9</accession>
    <name>A0A1E3IJR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029412.1">
        <property type="nucleotide sequence ID" value="XM_019178711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195868"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="652"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1543"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1695"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1725"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1748" mass="189532" checksum="5442092B33E9B793" modified="2017-01-18" version="1">MAEPPYSQGLGISLPNSPSRHPPSPLRHSTLGSPSKHADYPSPSPGKLQPKLRVRTEDLGRAAPPAFLLRPTHTKSGSGGGGGGGASLRTTGMGTKPMGPRRASAAQLKEAPSPRVDNHQPTPLQEHSQNPEPPAQAQQTHYLSPSRQPSVASNFTSSSRQSKQSRKMRSFEMGKKVSRHGTEGGKYAKLAGEEQEEPLGEENQAEAETITPRRLPPTQDLVEPTSPPPNPRSPASTAHHFLPSHHSSQDSGETHYSFPTPTSFPTPPNHQPRTSTSAPNGFMPQNHYSPGPYPQFEHPPPPQEHMPRSQSQPMQIYSVPEFFDPTYTSRPRAFDDADFPPRRAPNNGQAYEGHSRSKSVEVGRECEDEDLRLRPWSESTAPHGPQMLGRRGRSLSDGAELLARQGTLLHPASSNQRSSAELGLLLGGPKSRRLSRDKLLPPPPNEASTPTKKVKLEASKKGKARVEVDVVLERECVVEGGEVRGRMEVRISGGKGREGLRVGSGKVRVVGFEEISPSNRHIFYHHPHDLPIFDPALQSELSSSLFASGPDTDGYHLAAQGTHSVPFRMRLPLGAGAKGTYTHPTGKGACVRYVVVGSIKIHIPQNGKRSIAHFYRPIVVMPYLNPAVVLAPSSSPIEMYVERGLGWSLKGERGRVELRVGLGRKIWVSGQRLWCEVGIRNDSNKKIKSMSLAILQDVKVFGLKSPNLMTKRKSLSSLNSDASADSAGIITERRKVCEELTEADFTSHGAGRVTGKGWWTGVEPGESDHWDMSLQVPAGMLSIRRSRLVDVSYTLRVTLNNTIYVDVPIQLISFLSIDPPPMPNDEARPWAPMVPTVALAASDTRSPQFPQTEAQQAASPGALTSEYDHGPAARPSSTTLHVENFLQPPNAQARTLASPLEPHQPPPNRTQSPASSYTESRDHSRSQSALASEPPVLPGLLNIPSSSRSDVNSFEGMDFEDEDDDGIGNTVTRATRRAQGRQMSLAVIQAEAEHEERLRAGQEEISQDEVVEEDFTEYSGSECTRELDYDDDRAPLPIVEEGESTVDLGAYTHDHQPAAPQHEDEWDFGEDEEAAETPRPQYEPESGHETLLEAMVDEDRQELEEVMSMSGHGDRESHAWDYEDEMGSEGEEDGRGETPRPKEHSRSPNRFRLSAYKPSTPFEIDIPSDSDDSHPSAIFPAKPAGEMPVKEELETTQVQEAVRRPIVRVPSQLISVGGDSRRPSLATSAVSDSRRPSLAKSPSTHSLRAKAGRGTLGERLENVVNKADIASSPRRASVMSRKESLTSLTGKPGPTSPAMEGPAAKVLQKKNSFSFATPGSPLRARVKVAPSPVVSPTKTLAKLPLTTSPAKAPVRLPSVSSPTKTSARLPSGTSPTKVSYMAKGMERGMSGTPIRSQSTISSQPPPLQSSMMSDSASSDGRYLESPPSDSAAAMGYQTFSPLISTAGSTHHEWGGMHELGSPFDSKYARVHQDSVMSRLSLSRPRSPRNLEPINIPHDDDSSIRSRPMTPSTPSSCHSVLPSVKNKIAQLESRDEALRKFSVAGSAMLAPMGSPRKGVDGARQRKSYTAALAPRGERSASEAYRNPLPRQVSGSTVRTTNSTSSQYSYEYDPLYAPESPAYSTPTTPKRGSRLPESPSKVSLAGARLPASPTSSPASYRSAVYGAGAGADVSTYPSYASAPAKLDPFGIGYSSAGIGLGSVEEDREREGLEREGSMKSTSTTATDVERAFRWRDYGGQREGESLESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ILL3</accession>
    <name>A0A1E3ILL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000024">
        <property type="protein sequence ID" value="ODN88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029394.1">
        <property type="nucleotide sequence ID" value="XM_019178693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ILL3"/>
    <dbReference type="GeneID" id="30195850"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="174"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="337" mass="37254" checksum="3269CDC271663446" modified="2017-01-18" version="1">MPIAIPPPQSEDDSVLRLISLSECANDEALAKQLLAAANSDGFFYLQDHGIPQALIDGAFGASSSFFLGAPEGEKVAGNGDMGYTAPRVTDTLHSLSWFMPSSGDYKESFFVTDSSYMSAHNLHQQLPPTLEEKRELLDQFVKACGETAKRILRGLAVALGWDREALVKYHNGQHNRLRLLHYPPVSSDHQPADPNVPDIRAGAHTDLGSLTLLFQHHISGLQVSRHGQWLDVAPREGCVVVNIGDALEFWSGARLRSTIHRVVMPRTQAEQASRFSIAYFIQPDDETVLEPLGHSNFSEEEFGNIIESKGVPRDTKRVLGGEYKAMRVKRAQRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IMD4</accession>
    <name>A0A1E3IMD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_06446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000022">
        <property type="protein sequence ID" value="ODN89752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029661.1">
        <property type="nucleotide sequence ID" value="XM_019178505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195658"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="372"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN89752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1369" mass="149697" checksum="89B32D282CDA15AE" modified="2017-01-18" version="1">MDALIHPSIAIPTLPTIPQSAVPSPTSQRSPRGPTTPPLPIPHPQPSVPFPQRDGTDGSGTNRRSSLSCLPPAEGSYFPPTPSPSSRVASSSSSPGGTSRPRPPPLVLPTDSPDDADYGITPTTQGKGKEKAWDLVSDSPEQLRPACEIDREDPDEAVALRPIEPPNPHKSPSAGSIVRLIKKRSSASILGDRSDESVRISIRQSLSNLKEGLRRPASKSPETTLTPLHPLPPPCPERRISPKTRSRSFDSSKIDFSAPPPVTAESSLRRSKTVSNPRSPKPQSLLFTGECSPRHDEASVETHTSVSAGAFSPMSLTNNHPLSSATTSLSRSAKSGKEGQPGKAKERGSQDSLDSVKQWKTKQKVHHDRLEVRKQSLLELVEKTVSHAHALDILESVYLSSHNSSSLPASAVEDIRKLRPMVARIRKVNNRVKDIMVSVLKEEGIGYGQSLGKRKSEGDVFETKAEREQEERAHMEVMGEEFEERLDRAVSKISIAMLAEEKGFRKYTKLCVTGLNANKVFSGVSNGDRERFEARCKAQMDSREHYDLSALLETSTLGLTSVSKRRLHFEDFLHAPYQRIPGLVLLLQRVQDSFKGIPIKVGDDLDATSRAYADVGRLREMIARVGSTTDSARGVKMKEEATETLISRMDAHAEVTPEVLRSLGTCRLIGSLNVLYQHIEPLPKQATVKHLAAFLFDGYLILAKVKKNQKVYEPRHFFPLSMFVMYGVTTGPISPSIRLESGRFSYFLGALSAEEQAVWQDALDVARDKIVSPYAVPTSLPVPIPQAIQDGWIEAVWKSSADITKPISSPQQTPALSRRASMGATKSLDLERITPVTRAKRRSPEKRHTMTGLPTKSLNPDDILSALKTADAKSKNDSEPSTPVKSPVRTTFNAMTPDRNKESTQTLKQPQKSMIDNVMHGLEGILDSQCAQIRRGETIRKSQSMGASSRRKSTSQLVGFKDSIGATVFTGAVTESVIPKREPTLGHVKGRPSLPDDWQPGETSELPPAVADSDEEEEEDEEEEESGGTSRPISEFGASTSRQPLPRNGSSTSLFGVPSSKGSFLFMSASNDDSRNSLRMRTKRDKTRKGAALAENEIAKEKEKDPVGHARKKSEPTRRKISSKEGMAHYTHIREKSQPASPMLSPAHEQPSFENSLRHEDEQAVSTAPAEETVEEMAEGEDGVLLTAPGLKRRSFSYDSTPIARRPGPSRQITPPEYSIPEPHGPAPVQPFGASFGGFFDRSRRDSDRSRKDSRTSESAAPGGLSRRSSFVSVKSSLKRSLSGISLLSTRKSPNTEVPDIGMDDNTGSSAQSTPGTEFSPMSPITGLYGAEDDHGRDVLEMKRVAPTRQKSFKNLYGLGFSSMRPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INB9</accession>
    <name>A0A1E3INB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_06514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029476.1">
        <property type="nucleotide sequence ID" value="XM_019178569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INB9"/>
    <dbReference type="GeneID" id="30195726"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF40">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129851" description="Plasma membrane proteolipid 3" evidence="7">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10798" checksum="C9C77752E0CBCAE7" modified="2017-01-18" version="1">MPVKGSDIIIILVAILFPPAAAAMITGCSCDLLINILLTVLGYLPGHIHAFWLIYKRIKAEEAYGHGGYTYLGNGNFVGGAGGHPGAPVGAAPAQQPYYGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ61</accession>
    <name>A0A1E3IQ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_06038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029824.1">
        <property type="nucleotide sequence ID" value="XM_019178105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30195250"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="233"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="633"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="926"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN90722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1492" mass="165101" checksum="48285C72E1478A1E" modified="2017-01-18" version="1">MSNHASTSATATAAPSPPSLSTTVAGSVKKDDDLEFKGQKEVETDGIKRAVQVVLDQKSGKELLRDVEKDQQYTQPRWRHSLPFVKPAHPPPPAPLSLDDAKVTPEVDANWFDFLFFNWISPMMALGSARPLQDTDLWKMDDGRSAETFSRKLLTAYKQRTERANDYNAHILEAPIPRSKRILYSVLPNGEKREKAYREKLQKKRASLLMSLYDTFGWFYMSSGVIKMFGDTCQAVTPLLIRRLISWSGEYQAKKNAGLDLPSRGDGVGAAIGLLLLLVVSSMCQHHYFYRSMAVGVYARTAIVTGIYQRALQFTQKSRGQIPNGKLVNHISTDTSRIDFAAGFAHILWTAPVQMIIIIIILIVQIGYSALPGIAFLLIMTPLQARFMKTLFAFRMKAAKWTDKRAKLLQEILGGMRIVKYMAWEFPFLERINSIRTMELRYIRLLLIFRSGMMAFATSLPILAAILSFVTYSLSAHNLEAAKIFTVITLFQIMRMPLMMWPMTLSASADALNALKRLEAVFEAEVVTEERRVEGDMKEGIKLEHASFTWDAAPVDDETAMMKQAKGKHAKAIGGKAQTAPVKKEKKRMGWSKKMKKVTVADEVQAEAAGEKDGMGEAGAVGQGQSAPGAPGLDEKAEAKADKAIFHLDDITLSVPKGSLTAIVGPIGSGKSSLLQGLMGEMRKTSGTVTFSGPTALCAQTPWIQNATVRENILFGQPYDEERYWDAIRDSCLESDLELLEDGDGTQIGEKGINLSGGQKQRVNIARAIYFDADIIAFDDPLSALDAGVGKAIFFNAVIGALGDKTRVLVTHALHFLPYVDNIIMMEDGKIGQIGTYQELRHGDGPFARLIQDFGGEDKAEEDLETEQDAMENAGSKDVHDRSNMVTKGKAHELMQAEERNTGGLQNGTFFGYLKAGRGVILVPTLLFAVALAQAFTVITSFWLVWWEERKWPQSNGFYMGIYAGLGIGTALATFFQGFANATINYFASVRIHDNAIRRVMFAPQAFFDTTPLGRIMNRFSKDTDTIDNTLSDAMRMAVATLSSIIGAVILLAIIEPYFLIAVGVVSLLYAHNAMFYRRSSREFKRIDSILRSSLYSHFSESLSGVATIRSYGETERFYRDNIHFMDTENRAYYMTIINQRWLGLRLDMLGSLLSFSVAIIVVCSDISASSGGLGLSTIVTVQQSFSWLIRQIAEVENDMVGAERIMHYATNLEQEQPHQIEETKPAIEWPTEGKIEFKDVRMRYRPELPDVLKGLSMSVGASEKIGVVGRTGAGKSSIMVALFRMSELSQGSITIDGVDLSKIGLNDLRSGISIIPQDPLLFSGTLRSNVDPFGTKTDAELYDTLRRAHLITSSPGDTVSDSSRFTLDTVIEEEGGNLSVGERSLVSLARALVRDTKVLVLDEATASVDLETDAKIQETIRNVFKNRTLLCIAHRLKTILSYDRILVMSDGQVAEFDTPENLFLMNGAFTEMCGKASISLGDIRTAAGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQ66</accession>
    <name>A0A1E3IQ66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin (Alkyl hydroperoxide reductase subunit C)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_06060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029846.1">
        <property type="nucleotide sequence ID" value="XM_019178127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQ66"/>
    <dbReference type="GeneID" id="30195272"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000278">
        <property type="entry name" value="Peroxiredoxin (Alkyl hydroperoxide reductase subunit C)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN90744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="197" mass="21705" checksum="70E9D1DA9D54DFEA" modified="2017-01-18" version="1">MSAYPLPQIQKPAPNFAGTAVKEGSFEEIKLADYKGKWTVLFFYPMDFTFVCPTEILAFNKALDQFSAIGAELIGVSTDSEFTHLAWSQTNRKEGGLGPDLKLTLLADRNHAAAKAYGVLLPEEGVALRGTFFIDPTGTLRAMHVHDLPVGRSVEETIRVVKAFQFTDEHGEVCPAGWEEGKDTIDTANKDAYFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQK7</accession>
    <name>A0A1E3IQK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 25 (Mitochondrial carnitine/acylcarnitine transporter), member 20/29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_06135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029920.1">
        <property type="nucleotide sequence ID" value="XM_019178201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQK7"/>
    <dbReference type="GeneID" id="30195347"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN90818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="32457" checksum="64492FBF04F663C9" modified="2017-01-18" version="1">MSEILSPPPAPAGYITQSQKDLIGGSIGGIAQVLVGQPFDIVKVRVQTSPPGTYKSPLECATRLLKNDGPLGFYKGTLTPLLGIGACVSLQFGAMEYAKRFFRGRNGGGELSLGQFWLSGAFAGVTNTVVCNPVEHIRIRLQTQPDVVPKLYNGPLDCAAKLYKNGGGLSGIFKAQGATMWRDGIGCGFYFLAYEGLVQRHLKTTGLKREEISPIWAVTYGAAAGYALWFSIYPIDVIKSKLQTDSLLAADRKYTGMVDCVRKTWGAQGVKGFLGGLGPTLIRSPFANGATFVAFELAMRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQS8</accession>
    <name>A0A1E3IQS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L198_06102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029887.1">
        <property type="nucleotide sequence ID" value="XM_019178168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQS8"/>
    <dbReference type="GeneID" id="30195314"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="589"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODN90785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="783" mass="84651" checksum="E5EEAF3AD66E68D7" modified="2017-01-18" version="1">MAKNKGNSKQATNTRRPSAGPLIPTPDSAHAIAHVPTHSTDEKRDLKSANGTGANTPEEVEDDVCFICAEPIQFWSVGICGHRTCHVCAIRLRTFYKKDHCTFCKTELPTVYFSRLPTAGLILPGTLDLGAFPYVDDKLGVVFEDEDMMEATLTLLRFNCPYTDCGFQAVNWASLERHTLSTHGLVLCTLCRSQLSRFAHEQTLYPPHLLPLHDPSRVKRGQKPPKTRNAQEADLVKSWEAPHPVCEFCHRAYFGPDDLFKHMRIDHEECHVCREQGNRHVYFENYIRLEHHWRDDHYPCSQPQCLEDRFVVFGSELDLRAHMMEVHGNQMSARDRAQARTLQLDFSRPSGGESSGGRGFSLGGRNAGSSTGPSRMRNDGPQVQALDDTPAMTPAMIAQQRRQMAVDREGGTAGASSNQSARRRGFDGGLTRPAGQATNGPARSGPATPVTPAAPREDVDDVTVSRHEELLSRVTMLTGDSPTKLASFRHAVRSLKTNESSPRDMIDTIFNGVFELDLDVTVAIGREIAKLFASEGDKDKEKSILEAVSGLRAEQANEFPSLSTGSSQTGYGNHYAGVASGTVLNVKRATRPSAGQGRAVWDRVQQAAERGAASRPAPRATTGVGGRWVPGATTSRASPGSEAFPSLGSSSAGPSASSSRQTWASGSAGPSTSKAPSALVPQIRSVNNPSNPSTGRKPKAPNLSSFPSLPSSSKPKKTTKEERLALIGKPQGRAAAAEQPELGPREAMEGLSIGERPEGQQGGGKKGKGKGKQTLFTISARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ISG6</accession>
    <name>A0A1E3ISG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_05909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000019">
        <property type="protein sequence ID" value="ODN91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030021.1">
        <property type="nucleotide sequence ID" value="XM_019177982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ISG6"/>
    <dbReference type="GeneID" id="30195121"/>
    <dbReference type="OrthoDB" id="10494876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="158" mass="17184" checksum="AE6E9D3465EC85B7" modified="2017-01-18" version="1">MNIGNLAQLTTSASHIDDAVLRAAQSGDWDQVKMIESEIGEVSSLIDAYGWDWIDLALCDTAAALIQARNQRGTWNSLQSLVELTYHFDDSLGPRGNLQSAMETNDFKYASSVLDLLDEMENVTGPTSKALQQLSDILGSVASSMAVLENEMGLDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU38</accession>
    <name>A0A1E3IU38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030216.1">
        <property type="nucleotide sequence ID" value="XM_019177832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU38"/>
    <dbReference type="GeneID" id="30194966"/>
    <dbReference type="OrthoDB" id="2595387at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="180" mass="20121" checksum="3E115A4557B1F0F2" modified="2017-01-18" version="1">MEKPNYIGIYAPGDFAFQTYRIVFPVAPGSQQRGGGRRPKRGRGYRGWREEVVLETEQRSDINALLNLISDLAKDPEGPIATRHIVNPSQAKDEGVRLIWADDGEKGEEEMRDWPRREQMRKEGKTVKGEDDAMVLSIQAAISSDGSGMGAQWQTLESSSWTNRVFWADSLTPKSPTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUD4</accession>
    <name>A0A1E3IUD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030189.1">
        <property type="nucleotide sequence ID" value="XM_019177805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUD4"/>
    <dbReference type="GeneID" id="30194939"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="542" mass="60078" checksum="64FBE38D27D38A5E" modified="2017-01-18" version="1">MFKFSKPEPKKWFSSSYWHLDTPPASYATHDGWSNADVDVVPVEQRNWRAINYLFLWLADGANVGTMQQAGSIVALGLSWREASAAIAIGNIIIAAAVTLNGVIGSRHHVPFSIASRASLGFYFSYFAVISRLVLGLLYFGINTYIGASCTLICLEAIWPQLKTYPNAIPTSQGLASNRMIAYFVFWSIQFPLVMIHPRKMRWVFFVKSILAIVAAFATLGWAVNQAGGGGPIFSQRSSLSGSTKSWAWLAGINVAISGKTTLAINIPDLTRYARRTSDSYWQMLFIPIVYFVFSFIGIVIASAGQTIYGTLYWDPTSIIALWTNRAGAFFVAFAFAFATLGTNISTNSIATSNDLAFLAPKWINIKRGAFITSIIGGWATAPWKIQASATALTTFLSGYIIVLAPIVSIMIVDYWCVRKTHLHVPMLYQNEGIYQYKFGINWRAFLTLLIVIPMNLPGLIHAINNKVYIGNFVYFYRGSWLTSFFVAGSIYLIISLISPPTSTLVDSTVESLDEEVNDMHGWEKEQDLSDTNSYPAVNHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW01</accession>
    <name>A0A1E3IW01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_05588</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030420.1">
        <property type="nucleotide sequence ID" value="XM_019177669.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30194801"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="16">
        <location>
            <begin position="677"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="14">
        <location>
            <position position="875"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1335"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1441" mass="157742" checksum="0E17AA8889306C73" modified="2017-01-18" version="1">MAAVGMDQESIDRRELTSRCIAIMNRADPTFIEYMKYHIDNVDPSKGPTYEKVKQFGQILLENCQEVVDKPPVYRDVALPTAPHTEVSAKGDIVYSEISRNNVRKLESYVKEMASGGEVEPAVNLDKVQSDIEKLWELVNSQPSITPAQKSAIKSMYSEVVKSLGHSSEGSAVDDSFAPAAIARTKGPKQRRSSSQFLRPNVEDRTEVEETHLPFLHLKRKTGTSFSYSAKLTNIYFDVLTEIATSGVTFAKKAALLTGVGKGSIGVEILKGLLSGGCTCIVTTSRYSRAAVDYYKNIFHEIGSKGSKLIVVPYNGASRQDTEALVDYIYSTLQIDLDYIIPFAALPENGREIDGIDDKSELAHRLMLTNLLRLLGAVKTKKAARQFVTRPTQVVLPLSPNHGIFGNDGLYAESKISLETLFNRWSAESWGEYLCIAGAVIGWTRGTGLMSATNFVAEGLEKLGVRTFSAREMAFNILGLMHPLLFDITQIEPIWADLNGGMDRVAGLAEVMTSIRLDLNRVADLRKAITIDNAADFQVINGGDAERLHQKVAIAPRANFSYDFPKIEGDDVLAELKHLEGLVDLDKVIVCTGFAEVGPWGSSRTRWEMEARGEFTIEGCIEMAWMMGFIKHFDGKLGNGQTYVGWVDSKSNEPVDDKDVKTKYEKEIMAHAGIRLIEPEINWGYNPEKKGFIQEIELNHDLEPLEVAAEEAARFKREHGDKVDIWAQSSGEWFVKFNKGARVFLPKAVKFDRLVAGQLPTGWDAKRYGIPEDIIAQTDRTALWALTCTMEALVMSGVTDPYELYKHVHPSEVGTSLGSGMGGMHSMSAMFRDRREEKDVQKDVLQETFINTVAGWVNLLLLSSSGPVKIPVGACATALQSVEIACDSILSGKAKVMFAGGFDDFSEEGSFEFANMKATSNAETEFAAGREPTEFSRPMTSTRAGFMESQGCGVHVVMSAKTAIEMGASIQGIVAYTSTHTDKAGRSIPAPGRGILSTAREVTPDHALPLLDIQYRSRQLAFRRKQVSQWLENEHELLRLELEGRNSQTGNEEWFAARVAFIDDEAKRQEKDALATFGMLEGSHPNIAPLRRALAVWGLDADSVGVVSCHGTSTKANDKNESGVYNLQFEQLGRTPGNAVPVITQKGLTGHPKGGAAAWMFNGMCQTLNSALVPGNHNADNISEELRAFPHLFYPSKPIQHVRLECGLLTSFGFGQVGGQVAIVHPRYLFAALSSHELEAYKKRRTTRELDTYSRMSQAIVNNNLVQIKEAPPYSAELEGDVLLNPLARAGPSKNSFAFTGKLPNKAPIDYKNAETLRAVFEQSQGVAGVGVDTELINSVPTSDTFRERNFTPGEIEYCNSAPNPTASFAGRWAAKEAVFKALSVPSKGAGAPLKEIEIVSTEAGPSVKLSGDALSAAGTKTVKVSLSHSDNSVVAFAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW46</accession>
    <name>A0A1E3IW46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030405.1">
        <property type="nucleotide sequence ID" value="XM_019177654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW46"/>
    <dbReference type="GeneID" id="30194786"/>
    <dbReference type="OrthoDB" id="2564742at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="692" mass="74721" checksum="6C30A2B56BB7FCFB" modified="2017-01-18" version="1">MYPSNNVDYAYLPTPTSLPSKPPPRPHALDRNFRFPLHPPPPQPNFQRGQQGHGFSPSMSVKGSLDGAGFGGGGRHERTNTLQLNPGAPAEWADMGHGPPVSAVGGLKYDRSPLGHGFAPSVQHHSNSLPIHSPNSPHALPQINTNPLLTPGLTPPPINRAWTLDSSSRANLSPLAQSHGGRNLTRSPLAYEDGRSGASSPARSMVSSARSANGDGPERGDRRVFTAPSYTYHTGPDGPRSEQLAHPKPERASKGLRGRIGGPPKAVLGGPGGKTFDEMMTDQGKGLQSPEKASGGLTPSPRHSNRDDSSEGGEQEEEEVKWKGNRVVVRMPHKEYNPPESPLFVKNPEEEDGDHTPVEQLSRKEAFPWPAAQVRLSPESTPLPMSPRDAEHEDPGEALSRVPSPDIDCDIETVWNGKKLVLAIPEPDAWGSLTQERDERELEKMLDEMAAAEQAELDATPDEKEDDQVEDERIKEVLDDGEKTFDAHGSAAGLHRASTSTTHHPPLSPSQCPLPPSPIPSPPPPSSPPRSANSQSSAKRSQGVMQMNSFARRQLGGFLKQAAGDGDKEARPKLKRPTRRSESADIPPLAVKEKNADDGSPEAGPSQGTVKEVTQPSLQASILWSELQESEPERKSSVDEEERKPVKNEAVPLPASLLDLKRRVLASSSAVKEKKDKEKEDEKAASGWREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW54</accession>
    <name>A0A1E3IW54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_05623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030454.1">
        <property type="nucleotide sequence ID" value="XM_019177703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW54"/>
    <dbReference type="GeneID" id="30194836"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="32421" checksum="17A3FB012A6498AE" modified="2017-01-18" version="1">MAEVPASDSTLNGFFQAFVMIVVSEIGDKTFLIAAIMATRHARATVFGGAFASLVVMSILSAALGRVILGLIPKVWTLWAAALLFAVFGVKMLQEAHSMSGGNSHIQEEMREVEEELEEDSASHDTHNARGTAIPLESVEEGRPARTSGQGSSLMDRSASPRPGRQGPSINFPLSNSAEGGVGPLEKGKHWTVAIKDRIRETLQMVTNPVFAQAFVLTFLGEWGDRSQITTIAMAGAHSVAVIAFGTIVGHGVCTCGAVLGGRYLSTKISVKHITLIGAVAFIIFAFLYSIEGYYYVPENDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY53</accession>
    <name>A0A1E3IY53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA pseudouridine(38-40) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_05367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030607.1">
        <property type="nucleotide sequence ID" value="XM_019177454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY53"/>
    <dbReference type="GeneID" id="30194580"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="8">
        <location>
            <begin position="318"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN93502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="552" mass="62338" checksum="CC3F6EB613010E81" modified="2017-01-18" version="1">MEPTESTKRPLSPTPQNEAPEAKRPHLEAKPQQSVEIDPEEAMFNADNAGGNTKNKNNNKGSRGGKRANTKVQKKRDETREKKNLSSDGRVQRAWEPREVKEGETKEVKLPKKRCALLIGYCGTGYHGMQIQDHTARTIEGEIFAALVKAGAVSSDNAVDARKVDIARAARTDAGVHAAGNVISIKMITEPPLPEGYKTIAEYVNTFLPPQIRMWGWVRTVKSFNARTAADSRIYEYLLPSYCLLPPNKDDQLAQRLNETSPGWRDVVGEEACAFADARLPMPTSEEGEVDPKVRGEFERKRGYRVDEKTLNRFRDIVALYKGTHNFHNYTVGKPFNDRAVKRFMIKLEVKDPKVYGDIEWISVQIHGQSFMLHQIRKMISMAMLACRSGSPPSLLPETFGPKKIHIPKAPPLGLLLEAPQFGVYNDRIDKKMHGITEDRDPVNFGLYAEEIYAFKVKWIYEMLRQEELEKNVFHKWMQMMDNIRNNTLGYLNIKGVIPEEATAEALDAEGKRKKEEEAGATKDGADAKLEEEIESDDEVDQEALKRGDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1K3</accession>
    <name>A0A1E3J1K3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031026.1">
        <property type="nucleotide sequence ID" value="XM_019176994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1K3"/>
    <dbReference type="GeneID" id="30194104"/>
    <dbReference type="OrthoDB" id="2573559at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="719" mass="76028" checksum="9363648AA6707FBA" modified="2017-01-18" version="1">MDHRSSNILPAASQKSTTPLAAVLDYHRASDTSVESTPAGGETLGVRARRSTESISSSISTQTTVPTSHRDTSRDPHSNRSSHSHRLSANDLPDELLKSLGLGDGQLDQSSGDSFSGISSAVDMTPSSAGIGSVSSTPAELSFGPQSVPFTLKRRELINEGTPSRPGTASSSYFQMRQDESYPVNICAVNSGSSTSTDQAAKTHPDKKSLSSWRRTQILTAKRPELAPDTKPQAIPTLYGPHSLPYARNPSGVDATAADETAYLTHVFGLRPATGGASETNTQQSARVASSGSDSSGTQSYRSTSTSSVYNNVIAARKKSRDARVFSGIETDETYLVKPSMARSSHQKTKSGPGMIGETRGGVVSFNFDTLPLGSPASQQDTDSVSDSANRAKNIVLPDQEGKRVVSESALLEPKLGTSILGPSKSFANLRDASRLSPIPGSPSGFNRTLNAASIRQAYRARIRSASMSRVQPSHLSTAAHPDDDTSSFATPIRIPAFVPIYFDPASGTYGVGISPEATTMPSSDDEPSRPTQAGLKIPHPQAPSAQISKADTSDNWRHKFRPTSTVRPKKLYTPVSSQPQTPSTGGFRNEAGFSSSEVMTIDKLFEKYSPQVSSETSAEGPKLSHTAVAPAPASAAAHHVLTNITNVEISKSSRDQRSKSPQGVLRHRLAPAASIVPKGTPGAGRLLKKSVKVKDEDDENSLPPVPRDAVAAVSEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1R4</accession>
    <name>A0A1E3J1R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031051.1">
        <property type="nucleotide sequence ID" value="XM_019177019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1R4"/>
    <dbReference type="GeneID" id="30194129"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN94772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21327" checksum="2CD50AB3D29881F1" modified="2017-01-18" version="1">MSSLLEESHPAQSVSNISATSKPPAPPPSPIRTYTLRRDICAVPTDLLIQTFDDRVLVIVTQSGKVGCLTQATLPQFTPLPTPPPPSQDLQQIPPHLQILSILPPPPPQTTLTPLLGSPPQQALHELYVSQIATLVWWALQTSGEARKGVVVGLALKREKGEGRADEDGEEEGLVEKERERYAGILDLVSQWPGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1U9</accession>
    <name>A0A1E3J1U9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031093.1">
        <property type="nucleotide sequence ID" value="XM_019177061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1U9"/>
    <dbReference type="GeneID" id="30194174"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN94814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="305" mass="33324" checksum="A95D6D80EDD73033" modified="2017-01-18" version="1">MQLGRYSVSTLLPPPVHSITFSPDGRFFVVAAEKGYEVWKTWPLGLVRRRVLPGTLALALILPHSPLLILQGGGASPLYAPNKVVVYDDKVGEAVAELEFGERIRGVSARRGLFCVALSRKVVVFEYGLNGFWIRKFGEWETAKNEQGLMALSTAPGSTLLALPGRQAGHVQLIPLPSCPSSSPDPPSPSRTTPNSTFRSPIILAHTHSLASLSTTPSGSHILTTSERGTLLRVWDTQRGRLERELRRGVDPAEMWGVSFEGDVGGKGRVVGWSDKGTIHVWGRGENKEKLQVDHPFIHMLADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1V9</accession>
    <name>A0A1E3J1V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_05011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031142.1">
        <property type="nucleotide sequence ID" value="XM_019177110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1V9"/>
    <dbReference type="GeneID" id="30194224"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="516" mass="58465" checksum="99B8765808688CFD" modified="2017-01-18" version="1">MVLTPHGSLDLQPPPPPPAALSPLLLPDHPATADSYFTRPVPKHSRTSASSFSKLSEFSLDIPLLDDKDGIVASPEPVDENGVSGVRHTALSVDASEWRHPVFKQKVLAVLRRLRIPRWSSPVLTPTNVHLQKVSGALTNAVFFVSFNPAPNPTSPSESPLLTPTILPSDPTHPPPLTPEQYPQTLLFRVYGPSSDALISRSEELRILHVLNSQYGIGPKVYGTFTNGRVEQFFPSRALTAEELREPAISRGIARRLRELHSVDLRLLGYEQGKHTEPAVWKCLREWSEAAEEVLTQLEGLGSKWENWVQRFSLHKIRDEVRIYRQYVEANAGKGKEAVFAHNDTQYGNLLRLDNDLPPNTPDHRRYVVIDFEYASPNPRGFDIANHFHEWRANYHHPTLSHSLHPHFPYPSISQRSDFYRAYLSITVDGSNGKEIVGKRQDVPEERVQALEREVRLWSPGCSVFWSLWGIVQAQEHVDALADDNKDYKLEFDYLSYAVERLEMFRDEAKKMGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J267</accession>
    <name>A0A1E3J267_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030747.1">
        <property type="nucleotide sequence ID" value="XM_019177166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J267"/>
    <dbReference type="GeneID" id="30194283"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="243"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="557" mass="63354" checksum="65E31DD7F0FFDD27" modified="2017-01-18" version="1">MGGIGERLRIELTGRRLIWNIIWYGVHFFLFAYGWYSQATNTKLAALNGLKFSVWISRGAGLVLAFDGAVILVPMLRNVIKLVRPRLMWLFPADENIWFHRQVAYQMVFWTMVHTTAHYVNFINVERTQVRKQTAWEIHYTQPGGLTGHVMLLIMFVLYTTAHASIRQQCFEAFWYTHHLAFFFMIGLYTHATGCFVRDSVDPAYTSVFPFYDTEHCLGYESWRFTIWAGILYFGERIYREIRARRKTEIVKVLGHPSGAMEVRFSKPSFKYKAGQWLFLNVPEVSRFQWHPFTISSAPEDPFVSVHIRQVGDFTKALGARLGASPDQGLIPGQVAQDDEKGKGGRRGDFIQIDPKSLGLEMPKLRIDGPFGAPAEDVFGSEVAVLIGAGIGVTPFASILKHIWYAQRSGQCGALRRVEFIWSCRDTGTFGWFQSLLEEIEAAQTDPNFLRISIYLTQKMDSDQVQNIALNDIGQDYDPLTLLQSRTLFGRPNFKQIFQSLGTSLSHGTYLPGLEATLKTRVGVYFCGPSALARVIRSEALGVKSKAVDVKFYKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J300</accession>
    <name>A0A1E3J300_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031204.1">
        <property type="nucleotide sequence ID" value="XM_019176729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J300"/>
    <dbReference type="GeneID" id="30193825"/>
    <dbReference type="OrthoDB" id="2575097at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="35719" checksum="687500C6238BF038" modified="2017-01-18" version="1">MSRRDILEVTHFFPSETHDAIPVAARTLEKLKRLTGRGSGNSLRPEEVTALPAISALLACEVVQSKDLDENSAQKLSHTTKQYFRSALSKASQLLQENAEVSPSRSSSKRRSVTNSTSPAPSPSPSNVLTGEQVIAAITPRKTKQLYDSRRSQSLLTPSQFLNTPDKASPLRQSHVRIPSAQQMEGSPSKSGAGADVERTPTKKVKYSNPGIDLEHPPASYTRSGKRKGESTDAFFSTMATTPAGLKLAAKGSRGVDSEDGMMGADWLKRPTSPKKARTSREKGSRDKKRRKVDWTFQERNENEVSRNDLDDVRHTKETHLLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J382</accession>
    <name>A0A1E3J382_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031300.1">
        <property type="nucleotide sequence ID" value="XM_019176825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J382"/>
    <dbReference type="GeneID" id="30193929"/>
    <dbReference type="OrthoDB" id="10416459at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="183" mass="20534" checksum="92C0897343B84369" modified="2017-01-18" version="1">MKLHPPPIVHVRLPSSPSPSILQLTSITIGHVICYIALGSILKFQNPNNIQIEVGATVRRYYGADYTLFQRALIIRNYVEAQLLRLVEEFKLNKPFYTDLNHSGLTHGGLPLLIYHSKTTYLDAIQKGGSTLQPHYFEHGTTDAREVTKGSIEGKRVEVERAVGSVVCKKMMAERHKREAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J3K3</accession>
    <name>A0A1E3J3K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030975.1">
        <property type="nucleotide sequence ID" value="XM_019176943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J3K3"/>
    <dbReference type="GeneID" id="30194050"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027239" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="188"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="402" mass="44295" checksum="35F188FF50A443FB" modified="2017-01-18" version="1">MLLTPALLTLPLLAAAIPTNRGQLAFNQAPALSDHASGDIKHANYEGFSLDLNELRLVQFSEDEPPVWMTELQKIETKAKGVRFMDITDTPSLGFSGYLLPSAANVKYSYPTPGNHTKEIKKIIKGLDIGYMKKFLTKFTSFRTRYYRSDTGKESQQFLLKTLKDIAKPHSGITIKEFPHPWGQNSIIVHFSPSSSSAKEEPVTIIGAHQDSANSWPFLPAPGADDDGSGTTSSLEAFRNLVAANYTPSSPLEFHYFSAEEGGLLGSQAVAKSYEEEGKKVRAMLQMDMTAWVKEGTEERVGVVQDFVDPGLTDFVEGLISEYLSIPSVKTKCSYACSDHASFGKAGYQSAFAIEATFEDSNTRNIHSTQDTFDHPEFSWTHMREFSKLAIAFALELAGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4E1</accession>
    <name>A0A1E3J4E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_04358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031405.1">
        <property type="nucleotide sequence ID" value="XM_019176477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4E1"/>
    <dbReference type="GeneID" id="30193571"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN95740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29457" checksum="62ED351643B79E29" modified="2017-01-18" version="1">MSTPVEIPVDLVGQSSLYNVPDPILRRLRLEDQHGQTIKDLDKYFAEKEVLVFYAGAQYKSAAVIYVSADTDPLAPASVLQGKPWLRMIFNDDSDFALVRKEKDGGPPRIQEVARGENFIQAGEMELGMEKVELGVEEYQNEYVRPLSRAGLTSIMDVFATPSVAVYHLESHQFVAKNVKPAAFKPTTIDKTYDTWRKGGEPSLRVIGVDVVRTLKLPLIGLLLAVIYRLLILFGGDEYHVIPRWLDGVSWNQGGRGLSSDALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4N6</accession>
    <name>A0A1E3J4N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_04437</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031484.1">
        <property type="nucleotide sequence ID" value="XM_019176556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4N6"/>
    <dbReference type="GeneID" id="30193650"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="417"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="554"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="955"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1062"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1071"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN95819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126148" checksum="92A9E0B136833CB3" modified="2017-01-18" version="1">MGVPALFRWLSKKYPKIVAKVNEQTPTKVRGPDGELIEEPIRYENPNPNGFEVDNLYLDMNGIVHPCTHPEGKPAPETEEEMMVEIFNYTERVVNMCRPRKVLMMAIDGVAPRAKMNQQRSRRFRAAQEAADKEEERKEAIELFKAMGHTVSDETANKKGWDTNAITPGTPFMDLLSISLKYWVSHKLSTDPGWKDLKIILSDSSVPGEGEHKIMDWIRRQRSYPTWDANTSHVIYGLDADLIMLSLATHEPNFRVLREDVFAQSSRGPPVCKNCGKAGHIIANCKADKVMKDPNEKKVVEVAKTEELKPFIFLDVSTLREYLAIELNLPGLPFPFDLEVAIDDWIFMIFFVGNDFLPHLPSLEIREGAIDMLLKIWRAELPRMGGYLTNHGKVNLDRAQVILEGLAKAEDEIFQKRKSDEDRQENQQKRRRVDEHRRQDDEKAREEAAKNGTVSLNGTDYVPVQAAATARGGALHPSLPTRPAFDLVPKKEADAKSASAPASKAAQALGGSNSDIVKNRRAIRMANMSAAQALKAELEGDDGEANAVTDEMAKKAEGKEDAEAVVAVQRTEDEEKEQLSKQGAKATLEEQGGDEGVDEDVVPAAIKADEEDGEPPLGDATMAEAEDTEESTEAPRKRKRGSDGEDDGDAAEDDDVEAPPNPEADQPVPKKKMNVNPDGTVDYVDDVRLWEPGYRERYYEQKFGVSSTDRSLIDTVTKCYMEGLCWVLEYYYQGVPAWDWYYPYHYAPFAQDFQNIDQFDIKFEVSQPFKPFAQLLGVFPAASRIHLPDPLQTLMISEESPILDFYPPDFEIDMNGKKMAWQGVALLPFIDQKRLLDALGSKEPELTDDEKRRNSWGDQVMFISSNSDLYDVFCDKLYGLRAKDVVKPVPIDTTASHGMTGTVLADPNCVPNATFDSPLPTIEACPDVNPNDSLSVRYYFPRQSHPHRSVLLKNFKPAPPRLTESDKDFVRRGGQGGGRGGRGGHRGGGGYNQPTGGPGMGRGRYESGPHQRGQGYGQTPAPRQDYGAPQTHGYAPPPRPVAAYGAPAGGYGYQNPYAAAPPAPYGGGAYGAPPSAAYGAPYGGARPPFPPTQTPYGGPPRPPAGGYGGGYGAPPRGGGAYNPYGGQSGAYQPRNGGAPPPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q7</accession>
    <name>A0A1E3J4Q7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031535.1">
        <property type="nucleotide sequence ID" value="XM_019176607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q7"/>
    <dbReference type="GeneID" id="30193702"/>
    <dbReference type="OrthoDB" id="2562097at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="39125" checksum="7C007BB0812B19D1" modified="2017-01-18" version="1">MLRTTPLRLAQASAAPSRAAIRPRSIPRPPQSQLTALRATCRSYATEVPPSGPASGATGGGGGGGNGPMLLVLAAIVGVGAGGYYYLKPVRDAASVANTVTDQVKTNSPDLSELAGYAKSALPPGVFALYSHLSKQPGGINGFLSNLKDKDLKEVLEELKKVGGDDVKRVVDKVQKKIEDAKGNVENVDWKALVADLKGELPPGSQKIVDLLIGKLPDKADIDNLVKKAKEVGEDQLKQLESSANKVWLKVEEARKDGKGQADALLKGLKEAAPADVDALIKQLKEAAKKAGLPADQTEAWLKSKVDEGKINTDELAGQVESKLKTASKFIPGEPKDLVKQVEQVSPSLAKLVAQALQQSGVTDENGNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4R5</accession>
    <name>A0A1E3J4R5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031507.1">
        <property type="nucleotide sequence ID" value="XM_019176579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4R5"/>
    <dbReference type="GeneID" id="30193673"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="410"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="508"/>
            <end position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="766" mass="82851" checksum="618C180929A61F66" modified="2017-01-18" version="1">MEQENNAPSRLPRLASPAAKHSGIPLPSLASTMAPLASSNNANKRKMPESPMRPPTGKRSVSGSGVGKAPTGAAASAGLRTSQRKPSGGFVPTTQRKPTTLTRPATSMGVSTRRAVGSTGSSTSASSSTAGRTAAKPTAAAGRARSGLAPPPTARRPVAASTSGPSAPNLRANSAMGRSMGPSSRLTRSNAGAGPSKDQDGRLENVEKMVGGFHDLLEKEQAKISNLQLSHVDLQTLLQSTQSTERAARRDLSTASEELSSLRAAHAREVDELERTILRKDREKRGLEEEVRDSREELSRERDSVRTFKAQLAEQSTKHLTLEAQLSASQTQLTILQTEVERATLAVSAMKAELQVGQDRAQAAELAAEQKVRQAEEDRDRRIGEIEEELRNAETIRRKLHNQVQELKGNIRVFARVRPVLGHELQNPEGIADIAYGDERTAQETGQSQIVVTSKSESATGKNREQINQFTFDKIFSPKAGQQDVFEEISMLAQSVLDGYNVCIFAYGQTGSGKSWTMEGGQSEEEAGMIPRAIDMIFKTSDYLKDRGWKYQMEGQYLEVYNEVINDLLGSGQFDTKKHEIKLDKDGKISVTDAVSVPLSNPLQVHNLLARARGRRAVAATLMNERSSRSHSVFTLKVKGVNPLTDEKCEAMLNLVDLAGSERLEKSGAGENKDRLKETININKSLSALADVIGALGQGQQGGHVPYRNSTLTRLLQTSLSGSSKTLMMCNLSPLATHLGESLCSLRFATKVNTTQVGQAKKAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J500</accession>
    <name>A0A1E3J500_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031582.1">
        <property type="nucleotide sequence ID" value="XM_019176654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J500"/>
    <dbReference type="GeneID" id="30193749"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="41383" checksum="AA4C5629DA74EFED" modified="2017-01-18" version="1">MPPLTILPFLQSVPLATRAITALYLAVTVPALIWNALYPRDQYGASTLHSLDWLLLVPETSWKYPWTLFTAGLVELNFINAVISAISLPLACRYLERVWGPRELIRFCILVIVGSNIIAFGFSWLMFFVTGKEEDTIYGTPYHGLSGLQVAFLVAFTQLIPEHQVQLLGTIKVRVKTLPGIHLLISNILVILLDPSPYMLIQFGFFVGWVYLRFFKLAEGGEFRGDRSETFAFQYWFPPPVRPYISIAANKVFALATKIGLVQPWEEPAGSYGLLPGPGGAGGAGNARAEAERRRAMALKALDARLASSPSPAPAPAPAPAPAPAPSSSSTSTSNPTNPPAQAQGASSSTSTSALPTAPPAAMVAASTSATTAAASSGGGKKDGKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J5G7</accession>
    <name>A0A1E3J5G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031550.1">
        <property type="nucleotide sequence ID" value="XM_019176622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J5G7"/>
    <dbReference type="GeneID" id="30193717"/>
    <dbReference type="OrthoDB" id="10354801at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="128" mass="14033" checksum="E46B6793E8DF9649" modified="2017-01-18" version="1">MSGSDYWQNMPQDGADDACVNPSDLSLEPALDTDGEAPEIDLEASKQQSTPYASLCASHPGESNLPRDNPFAQRTGKGWLKSHCGRSQTCVSSLIEAGDLDETDQEIIDDVRGQMVDERKRKAGHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6N8</accession>
    <name>A0A1E3J6N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031773.1">
        <property type="nucleotide sequence ID" value="XM_019176363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6N8"/>
    <dbReference type="GeneID" id="30193455"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="117"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="303" mass="33015" checksum="B3D7C6A37E2D5D3E" modified="2017-01-18" version="1">MPVQEIQSAQQFDSIVSSLPPTQLLVVDFHAAWCGPCHAIAPVLKQLSGVYQHVKFVKIDVDQQRDLASRFRITAMPTFKFLKAGREVEQLRGASPPQLQQIIARHAGVPPPAGSASSTTTGEVTESLLRHVISKGLNCLNESKTHPLSSILGPDRGPRGTSFLESDVDPELLISIPFQDPIKLKHISIFSGISPSQAPKTIKLFINQPNIGFDEADSLTPAQEIELTADQVKGDKIELRFVRFQNVRSLHILVKDNQEDEETTRIDSIDLFGAASGDKAEATPQQSGAAPGGSMLERLMGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J983</accession>
    <name>A0A1E3J983_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032011.1">
        <property type="nucleotide sequence ID" value="XM_019176098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J983"/>
    <dbReference type="GeneID" id="30193186"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN97409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="138" mass="15323" checksum="180C551419EDEB7C" modified="2017-01-18" version="1">MIFRLARSARPTASLRTTLLTQRGFHATRIARDHFLDATPEAFEKRALDAGNAKPVLVDFYADWCQPCRVLSPLLKAVTGPETEFDLMTVNVDNHPEIAGNYKISALPTVVAFKNGAVKNKFIGFKGQDDINKFLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBP5</accession>
    <name>A0A1E3JBP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032124.1">
        <property type="nucleotide sequence ID" value="XM_019175634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBP5"/>
    <dbReference type="GeneID" id="30192718"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="235" mass="25306" checksum="291F2CADD6F201E6" modified="2017-01-18" version="1">MSSHNRGDDDGTADDLVNNMSNFAMDYDYGDDITSRMASANMGESSAGPSRGKGKGIFLGEESQSLYGGYGVPKAPELPGSALMAGYNDYQPDGHEYDGGEYIYDNDRDDNTAFIPISTEPENYNEQDEASGAPSPPPPISAPDPSGYFFYAPTARAEDVGLTPEEYIARNSKQATSRRNSYTSSAGGSRSRRGSEEVGRDHTGSGVRKKPKSKGTGGSTRSYRSREWNPGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC22</accession>
    <name>A0A1E3JC22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032290.1">
        <property type="nucleotide sequence ID" value="XM_019175800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC22"/>
    <dbReference type="GeneID" id="30192885"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF71">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="114817" checksum="E2946B5264F2FC13" modified="2017-01-18" version="1">MPLKRKGTGKKKKSARKSHQPEPPSPSPPSSRATSPTPTSPPANPEPAQTFQPYEMTPTKESFDASLRRALVETHTVLAPLEELIHASGPGKPLELASPEQGTSNGVSISDGAPDSPSAKPEFSQAYYIAMALLPLDLKKYIEEVSAPDVDGLLDEDGSFHPSRLETDQPPQSLMRQISRSSPTVQQAFVTAYHEKMRKEAGPAYDLMGDVVGGMGMGTVMGGMGTMGMRPDMGLRAAMGGPKHMLGGVPTRAMSHNHSDGCCSGHPALGLPTSPAPPYRASAIDDNYSNQLGVDLGGPNFGSGLLPPPHMLFPAGSMPPGDEGEDEEARLAAISERKKKKNGKSKERARMKKIEAKQAGRVAGDETEKASEEDEPQEASQDNNSSTALLHESPTSSNTVFVSPSSAPEELIVTPLVRDTGHGMTQVQPKDTGKAIMEKVNSGATMKMPDMEVTAEPVSIDPKDTDTASESAATYALPPASPEILVSRRQGTMAGRSRTFAVLDKMPDVVPVAAPQDEPLPRRTTPEPTRPSLPTRRSSGTMAGRSLTFTPVEETPDPLEIAGESDGECADEVRVKDQVGYDDLWEEDDDSSDDVETSLAATAPLTVITEEEEALEEGEVREETGPTAGALEVIPEVSRVNSVTPLAGAKANAEAKIPEPPEKTSLGVSNGTTVTTNMSLEPPSTVGSPVPSDTTEVDDQPTTIYRIPSELSGRRNSEPFVSPLPTPDMERSLSWGPLKPVFRVQGRSEIGLPSPRQEKPVTRPGVLERTMSTPTGFGHDSRPTVFGERMAGAPGLRRNNSTGLGRWSTTSSASTSPDRSRRGGDMGSFGRPQSAHVYTDRSPGNRSPLLPDQQLPSDPSTARPDMKVHPLDRPWTLYFSDSSEKAESQQSAREYDSGLVKVFHAACIEDLFGSWKALRRAIAYSKGREIEPEGRPLEGGGGLGMWLMGDDTNFHLFADGIKPMWEDPMCAKGGKLMMAGDAKKMDDVFLELCLLLVGGNLEVDMPPLTKPSVCGAIVSRRKTTTRIEVWLGGRDVPDKRWVNDVHDKLSNFFPQIRVLPYKSFHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCA0</accession>
    <name>A0A1E3JCA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032370.1">
        <property type="nucleotide sequence ID" value="XM_019175880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCA0"/>
    <dbReference type="GeneID" id="30192967"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN98508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="934" mass="100581" checksum="47E91AF0FCCF2824" modified="2017-01-18" version="1">MAPPRPSPSATSLKSARHVPLLSLAPPALALGDELALGSPGEDNNVGEIWNVITRAADLVKDGERLENLAWRHWGQPRRMPSFSHHDRPLSSSSQGSASSASIQTPQETSYFSRLGPRHPHPRHQPPCQQRMTFGAALLLLVEKDEGNFKDWVEDAKRGIPCSPPLPTFSVPETPQRSSPENGVQIHLVEPTPVPSRAGSLGGNSIIPSMSGRDVPPALKEDVEEEEAAAKTSAHENLHRVRIAPIDTERARGVSPRKKGKFFFQSSPSKGSGSDSPATSPHNSSKHESPPPSTMAPPASFTRGHPRRKSSGDSSAIMAVAKKSPATKRHVSLTTMRGKFQAEKRKAAEAIAQKHDEKAGNEESGWEDEESDWEDEEEPEGEDDEDWSDEDGDGAKSEEDISEPQPASQLKSPVRKGLSPIKKSPSPQRPSETQSKTRDPNRRRSNSRPRPGLATITQSQSEAGSDSLKRRTTWHGDRSNTAPNLAMSRQPPPVPAPAPVPKLSKKERQAAAAERAKVEARLDAQRKREMFAKQNVLGGMGTRPPSGLLASALQRGASMVDLPTVSQDRPPIKSSPTHAQLTSLAHSPHPGPSLLRSKSTAAMPVQSGVSVTVTGGHISQAAGKNAATGSSSESHKKTKPVVELESDSEDGDDDYLNTSHIHQKLAELDSKQEAKSKAKAEAGTQTSPATTASVNDAAPAQPAAAAASRALPVSARANEFGVVQPMMTPTTRRRNIIMAEMSESLRRNVVLEREKSSTGLSRILSGGSSRTRPPPSMVPSHHSAVNLTQYAQPEPLVEHRQPQSARNVNPPYPYSLQDQDPHASSVPRHQHSTIDQRKRPAPNVLAGGNLLRPLTRVGPMAAQEEAANMGSIGRTQSSGTLGNGGRGETAVPQPQAPTMIRSATTDGDGGQSQRERREWKRINLMDTSYRIHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCC2</accession>
    <name>A0A1E3JCC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032385.1">
        <property type="nucleotide sequence ID" value="XM_019175895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCC2"/>
    <dbReference type="GeneID" id="30192982"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111756" checksum="337C142AE603639B" modified="2017-01-18" version="1">MPLSTSPRKHLPAIRLATDTAPRSSTHTSRSHARRDRAPRLSRGGDRTQDWVRQVEQSRARGAMHIVDGDDLVSVDEPYTQPSCWSESVSTDVFDSLVDELNPSPSSLPSLPTTASIISANESRRYILQSDSEDEEDRRKNKKESSSRPRYNSLLSPEAPKAARKSRKSKDHARSVPNSPISPLDPAAPIMAPYDLPDEYQPPEPSPPPPPNLKPVVPVLSINDIINRHKQALGAAEKAVNDRARKEMGLSRKESPKKESLGLKELPSPTKGSPIKTLSPKELPSPNNGFPSPKKVTSPNKELPNPMKRLPSPTKEFPHRPHPPVPEKTRLDPIAPSRTGQRSPGPIVPTQSQRMSRVETELDIPPQVPSKSPITTVSPPHPPLPERNNTYPRARAPSAPKAYHGLRTPESKPNAQDPRNASALQRSHPSQERPPVAKRFLPAPTANSSNTSLSAEEFLLGARIGQALLDQLDHDSAPSLPTTPSVPTLQSRRSSVDKPPGSFRRQRTLSRTSSTPSTTPRGPKRLSMPVTPNSTASHTEGEIHDHAKYLRSPHLNRTLSIPRQSPDPPLTVSWAEVGHPKGHPVVFFMGLGCVRYLIAFFDDIARAFNLRIICIDRWGLGKTTQVPQEKRTVYEWAKVVEKVLDDIKVDRFQLIAHSAGAPYALAVVERLGNRVRGTLHLLAPWVSTDIDGGYKWLKWVPKGVIKSATAAEWKLQSYLLGKPPPLTYKPVSHNAAPVSYGSPKPSLEEEALYRESKSAQATPQTTPAKGPGIVRKASQILRPRSSGTPPGKDKHGQLGHIRSLKSLRGHSESRVTTLSSPSINTPSSRSPKSSTPPTIGMDDSDAESDAEHDFGFGEGFDAMSINLKMPAPPSIKFRPSYSSFRTTSTASLPSTTETSWPSAPTSHAFTLVLTQASHAESEPGTTSDIFYVILNSQSKIAGPLVDYTKVNHPTKVWYGQKDDRISEKAMRWLERCMGDVQLVVVEGEGHGLLSSVKVMWDVFESLGGEARQWGRIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JDZ4</accession>
    <name>A0A1E3JDZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032188.1">
        <property type="nucleotide sequence ID" value="XM_019175698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JDZ4"/>
    <dbReference type="GeneID" id="30192783"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="152" mass="16807" checksum="0B148C6B82EC92A1" modified="2017-01-18" version="1">MSFARFGLRTLRSLPQSQVARSTNLISQSRLLSTEARKLIDDAVQSNPLVLFMKGSPEAPQCGFSRAVCQILDVQGVPRENIKSYNCLEDQELREGIKEYSEWPTIPQVYVKGEFVGGCDILLSMHQSGELEELLIKEGLAPPIPEGPESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF14</accession>
    <name>A0A1E3JF14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box and WD-40 domain-containing protein CDC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032547.1">
        <property type="nucleotide sequence ID" value="XM_019175444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF14"/>
    <dbReference type="GeneID" id="30192527"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="979"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN99470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111956" checksum="E3A3E82ED5CE4851" modified="2017-01-18" version="1">MAYNDLPQTGGRGPSSGVAWTTDGPSLRMEDAVVETVVTHTTRTTTSFQPISLPRVSSPTNLRLPDHLSSETYPLADQPAPADLRIFTMTLGGRRVVVQDDSAGAVESEISGPGWTRKLGSSRAIPVQSSTEEVVDEEVGFLQALNQTKGKDRKRNFSAESVRDAPTPPITGDEAARHSPPRKKARGLEEINIPHHQSGRALLSPLPSPDHAAATLGSSTPSSISPPNLGSGSELAALFSLPSLASHFDQLPDRLQQHFLMHLLRRSRMPTIQRISSFISNVLRRDFITQLPHEVAIHILRHVDGKSLANASRVCKRWKRVIDNERGVWKQRLLDEKLWSGFGTEESEEMLIRERYEAMDLHEQFVERSQSDHDDRLSPQASRRSLSDRPTPLKHVYRRRYQEQRDWIHTRPEHNSFIGHGTNVVTCLQFDDDKIVSASDDSSINVYNTSDGQLRRRLDGHEGGVWTLQYKGNTLVSGSTDRTVRIWDLEELRMTYVFTGHTSTVRCLRIVDPVWEEETQSYQPPVPMIVTGSRDATLRVWKLPQKDDPLYEGSVNPETAEQTSSEQNPFHVHLLEGHSLAVRAIATHGRICVSGSYDMSVRVWDIVTGTSLHHLTGHESKVYSIVYDPYRKRCASGSMDNTVKVWDVVSGECLHTLQGHTSLVGLLGLSPNYLVSAAADSSLRIWDPSSCEMENVLTSTGGAITCFQHDEVKVVSGSDGTLKLWDIKTGTFVRDLVVGISSVWQVAFNGNLLVAASNRNSQTVFDVFRFGQPSDHPVDDSSLDNLQPPRWERWAIEERKAAEKAKWATKLVPSKGHGKGSSKGRDIMQPGGSSSMDWDLPAKSPTRQKGRMWSGFSTNDETTPIPREQSHPSASIAPFDDAPEHNPDHWLNPSTSFNPSARDASPTPVAGSSRGRSRGTSSRSAAQVAETSLTQGEGRRSSIATGTSQGRGGGSSTSWLPGNVASSRSQYTLAALDESLGSDFGGNEEEFYGIEDDGAMDADDQVMEDFGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF15</accession>
    <name>A0A1E3JF15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L198_03264</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032499.1">
        <property type="nucleotide sequence ID" value="XM_019175396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF15"/>
    <dbReference type="GeneID" id="30192477"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051053">
        <property type="term" value="P:negative regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000925">
        <property type="entry name" value="DNA mismatch repair protein MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODN99422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="936" mass="103867" checksum="A6F484CD080FA20F" modified="2017-01-18" version="1">MPPKVDGMVRLFDRGDYFSAHGSDAVLIANEVFRTTNVLKYLGSGSKSKPTSSSTGGSTARGLASVTISSALTRAFLREALTAKQMRVEIYAPDVAAAGGKKDNSKWTISKSASPGNLSQVEDLLFSDKDLEVNAVSMAIKVVNSKDGGVLVGVGFVDVQEKIIGVAEFADDENFSNTESLLIQLGVKECILQDDDKRPEIAKLRMLVEWCGVIVTDRKSSEFQAKSVEQDLNRMLDEVHAGSTLPEFELKAAMSALSALINYLSLLSDVALHGQFRLHRHDLSQYMKLDASALKALSLMPNPQELGGNKNMSVFGLLNRCKTSQGMRLLGRWLKQPLVNLHEITQRQVMVEVFVDDANTRRTVQDKYLKSMPDFHRISKKFHRRVAGLEDVVRVYQAVQLLPGLVESLEEIELLNPRGKELLEEIWLKPLREHIGKLDNYSAMVEDTIDLEQLSSHNFVILPTIDEDLQRYREELLGVRDQLDEEHRKVGDDLGIDIEKKLHLENHHVYKYSFRITKAEAGLIRNKKEYIDLSTQKSGTIFTTKTLRGLSEEYFRLQELYEKQQRHLVKEVVAIAATYTPVLEVLDNLMAAVDVIVSMAHVSANAPIPYVKPTLHPKGSGNVVLTAARHPCLEAQDDVTFIPNDHHMLKGSSEFAIITGPNMGGKSTYIRQIGVIALMAQVGCFVPAEEAELPVFDCILARVGAGDSQLKGVSTFMAEMLETATILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIAEKIHCFCLFATHFHELTALAEKNAHVKNLHVEAHVKERSEGETGGKGRDITLLYKVSDGISDQSFGIHVAELANFPDSVVKLAKRKAEELEDFGEPDDISAPSAKYPKETIDEGTDLIKEFLATWKSRVSVDEDSDGGMQPSEEEMVSQLRATAEEFKGRFGENEWVKGLMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF25</accession>
    <name>A0A1E3JF25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromatin assembly factor 1 subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032521.1">
        <property type="nucleotide sequence ID" value="XM_019175418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF25"/>
    <dbReference type="GeneID" id="30192499"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001010">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="58"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="466"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="555"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN99444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="776" mass="82502" checksum="3DA354417E42FFAA" modified="2017-01-18" version="1">MRPKVLEIAWHETQAVYSCDFQPLPLTQLKRLLSASTSADDEEKDKPTSSATAAANAAASRQYRLATAGGDSKVRIWMVYPNIPSISPATYTALTGQDYTPHPPRVEYLATLSKHTAPVNVVRFSPNGQTLASAGDDGNVILWVPSDRPNVTFGETSEDLPDKEHWRLQKMLQVTTKHVYDLAWSPDGEFLIAGSTDNTATIWKAATGECVFALREHSHNVQGVSWDPLNEYIATQSSDRSVHVNTFAFRNGIPDVHPVTRATRMEIRHSRTPSISSASRPNMVRRGSTTSEAGSVITTASDFPETHFPGIAASAIGAPATPSASVPSTPQPAAPAPMNPPTSNRPSSRRSSFSGSQAAGSPALSAAAFSALGRSARSPSPIPPLPAIRAPPASSNVSLNQRLYGEEGATRFFRRLTFSPDGSLLLTPAGQIEDQVFKGSPMLGPRSLSQDASSESNSVPKPKHTETGKPTAYIYSRANLARAPIAHLPGHKTSSVAIRFCPVFYDLRQNGHVQSEPKHVTLDKSDTQPVHVSLSMPPPPAPSSSSTKEKEKETQNLGSVFDLPYRLLYAVACQDSVLLYDTQQAGPIAIFKGLHYAGFTDVAWSPDGQTLLLSSADGYCSMVTFDLGEIGTVHPTQQHHRQLQAIAQSHSLAGTPLASSHHRDSIHSQTSASGTPYSPAVGIRRSPAPSNLGGWGARSERESSVASSVAGVSASTRPSISSQGQGVLPTPTPSESGGAGAASLEDAANKRGGEQAAEGEAPKKKRRVALTHLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF31</accession>
    <name>A0A1E3JF31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019175883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF31"/>
    <dbReference type="GeneID" id="30192970"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
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    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="176"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN98511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="40033" checksum="69A12FA300610E28" modified="2017-01-18" version="1">MSFLADLSYNTTLVSTITPTALHAPFYHTARPHIFSFISDKYLSIAAPILAYWFYSTFFHLIDTAQFPYFENRRIHDSPEMLARNKVTIWDVIKAVVLQHVIQAVLAWWWIEDDEVILQREIYKDHLAAMGHMAPWVADGTLLVLGRRTGEQLLKNHGEAMVRWLYWWGIPAAQMIFAFFVIDSWQYFWHRAMHTNRWLYRHFHSHHHRLYCPYAFGALYNHPVEGFILDTLGAAIAEEVSFMTVRQATLLFTVSTLKTVDDHCGYRLWWDPCQLLFANNADYHDIHHQAYGIKANFSQPFFTNWDKILGTRMSREEADGKSRWKPVSGDHVLAQAPAKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JFD3</accession>
    <name>A0A1E3JFD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_03391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032624.1">
        <property type="nucleotide sequence ID" value="XM_019175521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JFD3"/>
    <dbReference type="GeneID" id="30192604"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="659"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN99547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113994" checksum="C274C8A575AAC4AA" modified="2017-01-18" version="1">MRWTTRLRLLAAPTLASFLSFVLSAVKPWGGISGQWAFLVYTSMLIFFFPRGRIGPQIELTVLGIAGGTIGIAWSSGVLAVAAWCGRRYGVDSDQTRAILGVGLALLCIASGLIRSSVRRFNTFSKIMVFFPIFMLTGQQTITHMTAALFLEQFYVVIFAGILPLISTLIFAPHHTLSHQFGAQVEESLKTICTLLPLSLQHITGNENSSPTISEPSEAEYPTAKSLESQPDRARLPSSQDQLAKKLKTTISNLQTSSSSYLRTTPSVDGQLPLLPTVVKSLQRIVRNPLLGTSQSPGERIQAALNKTFPHSQPGTPRGAKARTPVPSASSSIRSQSRSEVFHRRKPRHLTSLLPPEASSSSLTLSQHPGLKERSESLVGAMVEALQAIEQELPAKFGWAVEAAKEDKAEMNPHERLAGAKACLEEQVGCVQHVLGSLLGDLGGEDKDDTSDSESDVRRSASPSKYATSPLNRSPVPATFSETVEVRSVLHNRDRYRLAFVMTTLLDLAKDIQGLATTLNEAPAYEKPLSGWMHFLRLLWLNRSDNEEDRDHQREEPNLVPDESLPHDEKKEFQDMDFVSATLHQQHSALSTTSPKHRLGRAWKLFWDQHKVVKTRILMSRFMHDVKHSRHVLFAIKLAGGICLLSVPAWMPPGYSARNWYHSSRGGWMVVSYMFVLEDTTGAILKVGFLRALGTFIGAVVGFVCVLIAGRNPYGLVVLATVCSIPISYNVLFASIPGLGTSTGITLPPILFIPYLGLSDGQSDWFLTWNRFVDIVIGVVAAVLVGTWFWPVHARVQYFRVVSRTLEGLIEYCKSNLRMSRDLVRSTLVYRVDDKRYEELEGKIKRNIQLSRTLMKIQQQEVSLLPRPIKLYSEIIDAIERLLETLNEIRILRFSVPRKETVLDVLPLRRELISTVLINLWASSHAYGSRGPLPQFLPSPRVPLSELMDVTEEHSRHLRSARHNHHHPRETQSTRSTMAEGYQAELAVLYGMAENEALGEVCNILEELVASARTLFGTQSFLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JHX9</accession>
    <name>A0A1E3JHX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032598.1">
        <property type="nucleotide sequence ID" value="XM_019175495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JHX9"/>
    <dbReference type="GeneID" id="30192578"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="447" mass="48473" checksum="2F9495CC30F279EC" modified="2017-01-18" version="1">MSDTTLSPRLRHLLIKDDNAPIASLPPIRAYPSPTRPRFSTRPSSGIMLPPVSPTSDGQGWSASDSPPSSHSQQRPSTSPSTPSHLILPHPNRRSNSIMALLNSQPPSPTPSSNNSSAGSVIRAEPEWQRPSLSYPRRPPPATFPTIEQSSSAAYFDERPSLPPTPGSYYQSMSADGSSDERPTVYRRHSSHPYERYDRSVYAPPYHPPVHRHSTPHHTLPPSTSLMSPPSVPVYLDGTRPSPYDDFRIISTASRAPISRTTKACNSCRSRKVRCDAGAANGGVATGKEPCMRCRESGLECVYSTVQKKRGPCPGTARPSVSKSRRSSSQSRQSRSQARGSMSSKPQLSPMASHRSSVASSRSIQDVVTPEDTPWSHTPHGYGFPFPAASNGVQVQGYDWHAANSGAGSDKMPPAWTGAQVGPRGSYSTTPWDERRWSAEGGVRGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIQ4</accession>
    <name>A0A1E3JIQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_03087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032952.1">
        <property type="nucleotide sequence ID" value="XM_019175220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIQ4"/>
    <dbReference type="GeneID" id="30192300"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF12">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="5">
        <location>
            <begin position="364"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="839"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO00760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="985" mass="110509" checksum="9AAEC1943492625F" modified="2017-01-18" version="1">MKLSRTLEDVLGLRGLLAQWDSVNWDPRAEAGTGCLGREVEIQMELRLAYKHESRFSLRELDSLLDELASDNHFSQLSQVRSQTRSPTDILIELYRHVKLSPYALSVLTQIILQDLRPLLDPIPRLEGGRCPGSYLRIKSNTRPKQLTMRGAMMGWDPRMWTYYKGGRGNMDTCADLAEKLAATNASVAAEPKVGVNVEITKCRQGRSISDALKPFQSGAGRQASGAIWAETKYDGYRMQIHVELVGDKPKITIFSKSMRNSTDDRINSHAHQHSIICYALNLPCDPKLPKHSSFAPKLASLQQSGQSRPHSQMKTSVILEAEIVPYNEEDREGGRGPGIEEFWQIKKAGVGAPSATSSASGRWDNQSRHVCLVFFDCLHVDGRNLLHTRYDERRRILENAIVPIPGFSMLAERTKIRVALRPDHLVQRDLDDLFNASNLAREEGLVLKAAESTYAAMQWPWVKLKKDYIEGMGDCVDLVMVGAGWDVDRARELRVDTSVFTTFYLGSATSAGEHGKDLPHIKILFAVSYGLTRDMLEYYNALIRMERWKSRPFDKDDPLKKRCMGLSYNYTFEKSLSSLPSVLFNEPLCVEVMGAGFQKIPGSELFELRWPRLQKIHEKKDREWTEAPKSSEYVAIAHASLGWQAAHPDSHPRPSYPQVSPSRQLRRRRHSPAPASSSSTEWLDNHWHSCSTLQLIDKPNFSFTPSPAKRSNSAPELGQGYEAGKETSQEGSARFKREATPFDKMGSPRESPLEQGHSPTKSPLHLRGTTLNASGKTNHGPAHKFWDAISRGSKNNRAANSQMDGRGLSSAIVIDDNEPPALRSGMSPKKRRRLEPPVPIKAHKEVLQPAQPPVWDGGGAESWSSVVTSPSQPARSLPAIERQPLSQVQQRDHSAMSNMATTFMKDPARESIKAVKKQATDKDANQETKKTWDKPQTLLSRWRERKKREKAALAEKAQVQKELKRGGDLPQEQEMVQPPLAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JIS6</accession>
    <name>A0A1E3JIS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_03118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032983.1">
        <property type="nucleotide sequence ID" value="XM_019175251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JIS6"/>
    <dbReference type="GeneID" id="30192331"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55257" checksum="864DE2EDFF47FC82" modified="2017-01-18" version="1">MSVSLTHIFSYLPPPRPVVPLDYNLGFFNILLTALVLVAPHTGGWKLFRVGVAAPFISALWVYLAFVPVTICNYDHWGIPILLASFVARTFELLVFFPAETHTHRLAVDSTKLSPVAITSENTPLVPEQVPPPFTLAKLYWAASLWWSFRGLGWNYCCPLPASSRKAPFIKGSSRKEFFLSQAKFFALAWIWHDLMRTIMVFTEAADFFLPGATMSYDDLSFGQKALYSIIVVSRTWYGLNLSHMTVSCFIVALGGLLGWEGEILSPWGWPPLFGNFAELWKYPGLSTMWSRTWQGYNRRWLYVFGWIGISENILHLTHTGISAHPQAPPDSSSSANTPSPSGRVSPSHPIPTTGPSVQLPVKKMTTRLMFQNLVKSTIVFALSGLQHDLGTYALLSKTRAGQNITLQDALILTPFFVIQPLALAGEAAVKTVWRGWKFKAHPTWKKGSVGYTGQPGWLVLSERLLGFIWTWFWLGTSAKYYVSESFGQRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JKF5</accession>
    <name>A0A1E3JKF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_02917</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="AWGH01000007">
        <property type="protein sequence ID" value="ODO00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032789.1">
        <property type="nucleotide sequence ID" value="XM_019175057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JKF5"/>
    <dbReference type="GeneID" id="30192130"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="240" mass="25967" checksum="E45AF6E0C1FE20DA" modified="2017-01-18" version="1">MSRPTQQQNPATTAPAPFVFDPVPEAIDAVNRGEFVVVMDDENRENEGDLVCAASKVTTEGMAWMIKWTSGFICCSLPPSRLAALQLPPLLPPSGVSQDPKGTAYHLTVDSAPGKNPVTTGISAHDRAYTARILANEESVEGDLTRPGHMVTLRYTVGGVRARRGHTECAVDLCYLAGLPPAGLLCELVHPTDEAGEMARRDDCWRFAKEWGLKIISVEGLAEYVEREGKDLVPEALARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLR9</accession>
    <name>A0A1E3JLR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_02523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033050.1">
        <property type="nucleotide sequence ID" value="XM_019174671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JLR9"/>
    <dbReference type="GeneID" id="30191736"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO01798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26052" checksum="B9EFD090381DB529" modified="2017-01-18" version="1">MTSATPVFRLYIVRHGRTSYNAQSLLAGKLDIPLSAYGIAQSSHSSALFSTIPIHGTITSTLLRAKQTADIILESHIGVGVVSEARVEDGRLDERGLGEWEGKRVEEVGWVEEPEGAETFDEVSTRVSSFLTSLLSSFNPLASSRGTIEPNNILLVTHKDIITSFARLFSFAAKTPSGPEWRIPTSTVPGWRVELDDDVELLDGCSNLGVGSLEGFRVGDGDGDQWVLKIRAWAKEAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JLT2</accession>
    <name>A0A1E3JLT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Bacteriophytochrome histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L198_02568</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033093.1">
        <property type="nucleotide sequence ID" value="XM_019174714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30191781"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="714"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1499"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1316"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1649"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1316"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1334"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1443"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1463"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1655"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODO01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1669" mass="183358" checksum="223F8F3BEEA940CC" modified="2017-01-18" version="1">MPTSSQPPPSVNHRNQQPPQLSHGSGTQSPPSPTSTRPFAPDHAPPISSTDPSLSPTLRSSEFVFPSRPVYQGRMSDFQGSSNSGYSHKTSDVEESDIGLDTITQMLQKDKEADQLKPRPRPGAATYHGKHDREQRMSTSSAENAPAPHPQHGASTMVGKLSTPYSTDEGDERQPSLGFDQAFQGLDLSDKEGQRGEAQGEESKGVDPGDRGLVEQLEKLGPINQDSTPRDSSNPTPTHSSIATPQPYPAQSPDPQLDRKHRSHDSPITVDADESGEPSLVSDLSGIVRLGNLGWDDAGPNPRAKHAARQVSVKDFVNDQAQTTNMQDPNALGLADEEGVKRGEAAGQEKDTQVHDQFEEPQDEPALTARFQHVMTEEGHHVINGREGVLKKCEDEPITTPGAVQGFGVLMVLEEDEESGKLAIRQVSENSSKILGLSPKYLFQLDCFTRLLTNEQHNVLRDMLEYLPDPSHYLSEEAKKDATKRLVDQGPLVFLLSGFGEPGSSHAGQKGTASSSSAHEGRRQWTSWVAAHRPQDNTLLKVDEQQKPVPPSNIIILEFELEKDSYNPPFPTPEDTPSVPRARSYTTDSESARGTGATAGSNSSATSSDQTAPVHPAPPTPKGAATAQTPTPAEPSESDEQDEDIPAEKVQESTTNRAVPLQALERMRGQLPDKSGSARPRTRPIRSRPPGGSGTMDTFAVMSEINEQLGAAPDLETFLDVTVGLVQDVSRFHRVMLYQFDEAMHGVVVSELADRSKMKDLYRGLRFPAADIPPQARELYKINKVRMLYDRHIPTARMVLKYREDLDYPLDMTHSYLRAMSPIHLQYLANMGARSSMSISIMAFGQLWGLIACHSSGKSGMRVSFPFRQMLRLLSESISKNIERLSYAQRLKTRKIISTVPSINHPTGYIVSNADDLLQIFQADAGLLVIGDGCKLLGRQKQGPSMMAIAEYLRAKQLIAVKASSSLVKDFPDLTLPKTPDTAAGLLYIPLSYQAGQDFIVFLRRGQVREVQWAGKPTKDEASEGANLEPRLSFDLWVEQVMGTTRVWSDDQLESAGVLALIYGKFIQVWREKQTAMASSQLTAILLTNTSHAVRTPLSQIINTLELALSGTIDKETRDMLQSSHDASRSLLFHVHDLLDLTRIETGNETTFRDPFDLRQSITEAVRLYETEISRRGVEFRVKTGDDLPKFVVGDSKKVRTVISNLVANSVKFTSKGFIEVYCGVRSQTATSDDNEPSDRTVNIEIVISDSGCGIANDKLQAMFLTLEGSEESSQDSGVGLGLAVVARIVEQLQGQLRAESEEGIGTRILFSLPMKVHDPTRPNPARSRDSRSTSKKTSTRKRRSSTKSKAALRFDRSHVPDIDSFVQDLQSNHLCAAHEDDERLEAAGVRMSQPGSFPVADSSFPVMPAKLSTEAEALARSPSPERHNVRQGSLRFRRESSDQSSDQSSQPFPQSYSQTSTVPSPASSPKNTVTPSDSKPSASPKQSEQDAEDKSQLRVMVVEDDVINSQILQKRLKMDKHLVVAVTNGQECVDFLRNDRDIDAILMDIQMPIMDGRTAAREIRKLERSESKPPSDITPLLVDGRIPLFAVSASLYESDRTNLSENFDGWLLKPLDSSRMRAILAGLQDPSKRSEEVYKQGNWEAGGYFRGPESASSSPSSSHASSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMF7</accession>
    <name>A0A1E3JMF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033311.1">
        <property type="nucleotide sequence ID" value="XM_019174932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMF7"/>
    <dbReference type="GeneID" id="30192003"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="103731" checksum="C1FB42552F8D2FD1" modified="2017-01-18" version="1">MSASFPSLSHSHSAFPLPQVPEDTLHYTIHLPTSYSDPSATALLINQYVHTLLRHPWLWNKDSWELKVADFDSERSSEGPKLEGRMRVGDAVDDEWLVVWLLREVSRKWPELIISIRDTDGEFLLIEAANELPSWVSPDNADNRLWLQGAHLHLIPLSVRSAAAPHQLSDDMDSDPAIHLSESDALRAVRTGKYPASKAVEQAVWQRIAGYPDAMRTHLHRTNIYLPLAVAKALRQQPDLVQKAVEAFYVRDPAQLRAASRMTHFPPSPAVLTDITLTRAAYAQLQGQVFHAPRVFGPEWHVGDGADQGSESSPEKLDDQRRWRDLGVKVATGFEIMYREGGKSSRTGAQASNEVTQGPEYQTFLADLKRSGWFGEELEGSQKWKEREEEARKGYAEVKSADVASQRPSFAYLVDNAVSSSTLSPEDLTASADTPEDDDKWLEVSPDELDGLMLRASGQDGTKGAPGNKERMEVGEEHGQMLGDLAKKVQDFVGGQGDMQGARFLDELSDEDMMDSGSDSEEDEELQAHKKQLESEKQSRLSNLVPNLAAEDWGHKTSKPPAPKPNTEPAAAAQPTQTEKKANPLDFIPSTMRPPRFAKQEFDGVVSDSDDDDEDDGQLPAEGTWGRKIAQMKWGDFPPVDGEDDDGVAKIEEIEEDEDEQGRKEKLVLEDEALEEQMKRRVWGEDEAEEDEDDEMPEDIEDVEMEGEGDETQKFLDFSREALGISDEIWEGILQERKDRGSFVPELKKKEKIAAKEENRNFEDKPIKAGQGKKVQFSEEKVKVAPEPGQPNASLDSFDSVMRAMDEALAQSRPSAPAPAPIPGSKAPKKSKSKVSSANPLPPAPPGEDIDFDNFDEDDLLAMDRELRSVLVGAGVDPDALSDDDDDPEEVGMLDGEGRNEYEMMKNFLESWKSQGGESGAVGNLFGRLAQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JMR2</accession>
    <name>A0A1E3JMR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000006">
        <property type="protein sequence ID" value="ODO01946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033198.1">
        <property type="nucleotide sequence ID" value="XM_019174819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JMR2"/>
    <dbReference type="GeneID" id="30191890"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="678"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO01946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="849" mass="90570" checksum="16F92D61A55A9BB6" modified="2017-01-18" version="1">MSPPRRRIQSSTTLQSISIRSHAPPLTPRQLDANTHVPITRSRSRFISAAPSRNENIKPAAASVPGFSKSLRSRGPIKDKENNSRENLKMGVYEDKKMAGKRKAGEVDEGDRKGKVMKLGEQPIRRMGPPLKAVPSNGNIEVRQTLLAPLSSPRRPQPKVQVSAPPTPAREILRQGLLKSKASQESLAEEDKSASLVIVRPPTPPRKHQPLQSESRSGDEDSSMEEVSSFVARPPTPPRMRERPTSVLLSPCPDGQALYASPNRMNGSTTPLTSPGQLTSHTPLRSPRGPQALISKPMSPRPFSAFHAPATPPKASPHMAVSTTPATRPNVKSPLTARRIAAAARMAKETASLDVEMAKPSKKAETVLANTLVPTSSELAEEPVTLEEQKPTVVTEETTPIDMPQELALHVESKRLSELPPARSTSGPSQLSKSVSSRSLQGAGAPSRIPIGRAMPPIRETLAPSAGAKKPATNLGIVGPERSALASGASAMSPLTEVKRKPSYPSSLGSGPLACPTARVVSNPMLPPRDIPQSSQSSLRSITSPSSRSVSNPGPRPRLSLSSSRREGLSDETSKSLAGLSSALEKLKAKKQLSNSSLSESTSEPARRTAPSVTVSAPTRPHIFQDRPSNLSASTSTSATSAVAKPRTSVLPSDICVSAGAGDTSLGDQSIAGMLAEGGARCFKGVVAFVDVRTSDGSDSTQVFANILRGAGAKVLTRPGSTCTHIIYRSGREATLNWYRRQDEEDRPKLVGIKWVMDSKKAGKRVEEDKYLVDLSDETVFDKRRKSMEPKSLAESKGLLSTATKKRTLLSAAAADAKQRSKASYAPKRSSPLKKAFLSLPSSSNADTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR52</accession>
    <name>A0A1E3JR52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033410.1">
        <property type="nucleotide sequence ID" value="XM_019174358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR52"/>
    <dbReference type="GeneID" id="30191418"/>
    <dbReference type="OrthoDB" id="2574059at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="231" mass="23992" checksum="189BFC89F6E66E93" modified="2017-01-18" version="1">MANPLPSAPPRPITPTGTPPGTHTIDRADRETFHDSLPTPPPSRRPSFLSSLASLPFSFSPSNSIPSTPASTSTTHSRRESFNHGLGFGMTPASNASAVVDDHEDARGHAKKRSLSMLDRALPSGRDVPHLPPTAAHPDLPAAQPQAQALAATAPPTPGPNSGAGITRPKSTPHLPRNKQGFDTAAAEEGLGVQANVAGQGPPATTGGRRASDSGRRHFDPSRDPRLLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JR89</accession>
    <name>A0A1E3JR89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_02226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033431.1">
        <property type="nucleotide sequence ID" value="XM_019174379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JR89"/>
    <dbReference type="GeneID" id="30191439"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="454" mass="50063" checksum="9ED5B3267EC6070B" modified="2017-01-18" version="1">MALTDYFSPVAFFILLRESLEAGIIIAVLLGFITQIIPSKPPRRPSQTLRPSRPSTPEPRHSAESDLSNNSGTQLISSTSDIGSRYGASRNASPSRYYDEEHDNVHEEEVVLGGDVDRLAIMKKMRVQIWSGAMLGGSVAIGIGAIFLYVFYRYTRDLWQDAENLWEGGFCLLAAFLILVMSLAFLRLPHAQTKWRLKLLSAYQTQSGEEAPSPPPHYGNGLLHPHHAHRHKKRTNKANAILFGLPFITVLREGLEGIVFLGGIGLSEKPSSVFGGGLAGLIVGALCAYLLFSSTSPLSVHTFTAFSSLLLFYIGAGLCSRSAYALERQYFINHVGAAAAESGNGPGSYRVKGNIWHLTWWDPEPGSGDNWAQVAQAVVGWNNTGSWWTISTYIFYWVAITATLVYMKWKEGRCAILGILSPRGKELERSRRQRGGIGEDDEEVLLDDRSEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRJ7</accession>
    <name>A0A1E3JRJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033559.1">
        <property type="nucleotide sequence ID" value="XM_019174507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRJ7"/>
    <dbReference type="GeneID" id="30191568"/>
    <dbReference type="OrthoDB" id="10523607at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15040" checksum="654742942B4EB9C0" modified="2017-01-18" version="1">MSDYQQKTNDDASQNNTVGILHPMPENTAPTSSSAANTSSSSSAKKRGRGASMLQYLQSAHRSHAAARNREAELEETVTRLQSTTESTQNENEELKAMIEELQLLKTQAEQEEALSQEIDWEAIVNEIDWEKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRM6</accession>
    <name>A0A1E3JRM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein HET-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033546.1">
        <property type="nucleotide sequence ID" value="XM_019174494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRM6"/>
    <dbReference type="GeneID" id="30191555"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130517" evidence="2">
        <location>
            <begin position="25"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="796" mass="85854" checksum="A0A4D66941F25FBC" modified="2017-01-18" version="1">MAKTALLFLLVALVALSFTPQVAAFGAGNIPSFSYLEDKAFRHGDIEDVIANLFKAAGGGLLSRGTKFTPLDVKRVYFGNWLRDYSQAVDVGALKKTNLQTILNIVMVLGFMAHGYATGEFEVTKEALGCYLTTEHIDNPKGYADGEDARQYDDRLRGPVDDIELAIDPQTGMKNYIANENGHWDTSKALVRQRLQECIHYGRLYRANGNKADIYQAFQLLGRALHTLEDFTAHSNFCELALIHFGHQDVFPHVGQNTKVRAPNGRDVYPLVTGTFGGADFIHSLMGEATDHLSQSSVSDLSKQMTNARSISEGQTNSADTLRQLFFSLPRGNGDSMTRDLDGIQNMRAGQPGGVDPSNMSPQELHNVIWQILSFRDSVMKKIENTIDRIPGLAGIVEKISNSVSVFIITTLEPFVKPLLGTATQALGESSQSIIDSHDQYEVWTNPNASDPTHSYLSKDHFALILNQPAGEIAKIVVEHTVNLVVKAWDDTSMNTNQVTESALEAFHHPAFATGNSEIQRKMIDKMREWFESTGNDKNEILRRLSSANVKEGKNKRIGDTSTDTGHVHNQLLPEGGLQQVIAQQNIHVPGAQYLNDAQDLASGKMPWQQGFGSGGQNTWRDTAGNSGNAATAGVATAAVVGGATSAYHQTSTNNYGGADSSYGNAAPQQTYQSHQSHHQQPSYGAQPSYQSPTQQNFGSQPAYGGGGNEGYPGQHHGHYNSGSYGGGGGFGGPPPQQYGAPGGFQGGGFQGGPPQHGQGGFGGPPQYGQQQGGFGGQPQQQWGQYPGHQGPPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JRX8</accession>
    <name>A0A1E3JRX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033636.1">
        <property type="nucleotide sequence ID" value="XM_019174584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JRX8"/>
    <dbReference type="GeneID" id="30191646"/>
    <dbReference type="OrthoDB" id="2576251at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="570" mass="61101" checksum="47613A16EB8C79DA" modified="2017-01-18" version="1">MPLIQTVPGTPSPRLPTPNAADVEHEHTDEQDVENLLSTAPDDPQEQDETPTAPSSPPTTSTRLTISTAPTTPLSSPRLAPVPHGPAPEQGQEQEQVSPPSTPSTPVSSRFSHSTPQRPLPAQKQQTPRYDGLTSRRPVGWISSLAGAGSRGMSDNAIPSSKQRATSGISQSHGHGHSQGKGVEVRVSSVAFGGVEGRRVSGAMKYALQSGESREPRVGGGGGGRIVSTTSAQEFDLSQHQFDLATASADSPILNEREEDEDEDLGEDEAENIRYQVSTAQEQDELWMAHVREQLNTLFPDFFAAEPGDLGDLAGLGEDMAGRFQEEENDGEEEGEGDKSVGSVRVREVDDEVEGEGEEDGEGEEDQAEETSFTTSASATTSSSLNLQTPPPTGPSRSFSSSMPLHRTQRQVTRGRGSLGVPNVREEITDLREEIMRLRSVVGGLADGMRAEHAAEVAAIDREDPVEGVRKGEIEREQGQGQGQGQGEERMMQVPESYVRTANKSIEILLHLDTLVRVPDPTTSSPVPEQGGTRTLEMRDINAIFEESNLGKILEFVKGLGGAAGGEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JS14</accession>
    <name>A0A1E3JS14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_02511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033711.1">
        <property type="nucleotide sequence ID" value="XM_019174659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JS14"/>
    <dbReference type="GeneID" id="30191724"/>
    <dbReference type="OrthoDB" id="2565225at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="949"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO03660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="978" mass="103436" checksum="8AB7CFADF5CB0AE0" modified="2017-01-18" version="1">MPDRAQGSRGSRPPTMRENSNSLYSAYSPNWDTPRASVLFYNPPQPSQPNTPLYDDAPPVPPLPPPLPTPPALPPKDATVRDSIPLSGYTGSPDRTDFLAHLPEEIRGGGVYQGDLDAKVLAELLSPRKSSSIKSKSSRTRTKSRTRQTDTPPPLPPKPAPPTPSTSVYASSIAYSDTSVTTETPVQPRTAIRGRRETVSQAHAHLLNPSLASLVHLSQTHDAAGGDGAGVGGLGAALANLPWAEPPPRLPTPLQSPTTPITPSPLLPSPSPGLTPSYAFLASDPLPSSSLPHSHSRKPSTSSSFRSRPDSRLGPSDVPMSPSLGHASASASFAAHGFRDGYGEGNRLSNGSGYSGMADTWEGGGVTPYVDIPAEYLTSDWVDHPDPDADSHSGAATLGSSSHHPPSKTRFSIDPSSSGHSHTPRSFSLSRTKSSRSTRSTRSTKSTKSTRSYYNTRRASTSTLGHVFAKRWEVRRYDDLERERGLRSAPLDGGRVGPGGRSGRQGEGEGEWDGHGGEGGEGGGEEEWMDLGSLVGRAVVLEKMLRGGKRLSNQSKKGSYRLSRFTSSSTPSAHRPSISLSSQAQAQSTCHHLDLPPPLPSKSVSRSPMGMNGSNTPRSSFTASIPASIPASGTGRRSKHSSTTPSTTSASALAAKRRTLRDRLSRRLKRSKSREDTFTELGSSGDEGAGGEQKDEDEEGEGEEEDPGMFPDQLDAGDGDRPPRPVSKGAWRMSRRFSRLATVTAGGATPREAREKEAKDGHVQNVCKEKEAKGKDRIGGPGVLVFPEELSPTPTPPPAPAKDLHLISISTSNLPNASKKNKQGTGKHGKALRIPHCLTPTSPTPLLSDMEKGLGGEQDGPSANSNSSRGLVQGDDPASAPASAAADAAQVEPEKYHQSPHLGHRSPTWRHRQSILSTLSTGPAWTPVLSWREWWTAQGGSKGKRKRRFLMLGAVGAVVLVGVVGGVAGGVAGRGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JTC2</accession>
    <name>A0A1E3JTC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">L198_02203</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033408.1">
        <property type="nucleotide sequence ID" value="XM_019174356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JTC2"/>
    <dbReference type="GeneID" id="30191416"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130555" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="640"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="936"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="525"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ODO03357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117605" checksum="537AE1499F24BF1D" modified="2017-01-18" version="1">MLPTPLLFSLLAFLAFLLSVVASPEPAALIPFPQYTHRPAQPSPTQAPQVVINHDVHPLVLVSTVDGALHAIDRQTGTEKWVLDEGDPLVGGKMRGRDDEKYIVEPLSGSLYVHEEIEGEVKMRQLPLGVEQLIALSPFAFPDAPTQIFTGSKQTSLMSINLLTGEQVDCFPSAALNLSHHSAAVCENDELDDLERANALPVRDTLFVGRTDYRLTIHSPSPSAQGLSTYTSTVYSSSEKKGGPGVQEIRYSTYTPNSYNRPLADTWLKASVDHQSWGPDREEPRTRVELGFDGKALGVKPGAGIIWNKELGNVGIGVYEILLPRDSPHGAPVLVPQPPAHLPALFPEHGDARAFNIHRAPPSTYIATLPEHLALPTPQTNLTASDGKSVGDALHFALSSSSYPLINFARPARPGHLSDGLFFLAEDGDSSAEAHKSMLPFLIDAPKEHGLIDGPADVRTLEAGGIRQKVERAWWKWVLLFGMAVTILGAGIVNFARYRGGRVGVGEVDEKTPLLVVNEDKSKTEEVIPSITIQESTPSPAVPPAALPPTDTQPLAPPQKAGKKSTRRRVRGKKKRRDSNPILEEGEEGEFDEDGDGRESGRSSKTGGKPLPDLPRELSSTDLLDYQDKERLAISDQIIGESFLSIGFGSHGTVVLKGTWGGRPVAVKRLLSDFTRLASQEVKLLQASDDHPNVIRYYCQEKRDNFLYIALDLCQASLADLIESPEKHKELAAQLDRKKALMEVTRGVKHLHGMKIIHRDIKPQNVLVSQTPSGLRILVSDFGLARRLDQDQSSFAPTANNLAGSLGWRAPECIRGVVRLNEGFDQTASGTSSGGTVTAEGEACSSSRSRLTKAVDLFALGCLYFWILLSGEHPFGETYNRESNIVKGEAVNIDMLDILGEEREEAKDLIGRMLSMEPGERPETAECLTHPLFWAAGKRLAFLCDASDRFEIILDPTDPSHPECALHLLEDTAQQVVGKDWYSRLDKVFTSSLGKYRKYKGGSVRDLLRALRNKKHHYQDLDAHTQAHMGSLPSGFLLYFTSRYPRLVMHVYGAIRDSGLGGESMFEGYFADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JUP9</accession>
    <name>A0A1E3JUP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_02513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000005">
        <property type="protein sequence ID" value="ODO03662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033713.1">
        <property type="nucleotide sequence ID" value="XM_019174661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JUP9"/>
    <dbReference type="GeneID" id="30191726"/>
    <dbReference type="OrthoDB" id="2578337at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO03662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="146" mass="16067" checksum="3111F7F949DA7CCE" modified="2017-01-18" version="1">MPGSKYDSLRTYHKGGINPSTRQAEDGTICTSPSTELPITTTNRDRDPYGPSHVSRSQYMSSRRSKTETSQQAASSRSATAPELEQSTGLPMSFLETLPRSTEKVKSSDASATRQKLLDSEYIIINEVKAGNGYTTFSYVDTPEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JYL1</accession>
    <name>A0A1E3JYL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033952.1">
        <property type="nucleotide sequence ID" value="XM_019174145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JYL1"/>
    <dbReference type="GeneID" id="30191202"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO05297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="41023" checksum="A3DF1D99BC90648A" modified="2017-01-18" version="1">MPDLNELLKWSIANSTNPEAAQEAASEQAEQLQLRFNPVSTHSGNSALHPNDRAPAPVPDLSPASTPGPGTPKDGEPLPLPSGAKREDLTTEMLDLIMGKSDSITMKEKIAYASNEENPVEERVEALDDFEMLIELIDNANNMPILKLWQPLLALLASPHPEIVAHTCWIIGTAVQNNLKAQAALYIFDALPQILNTLYPSTAPQTPAVRAKATYALSSALKHWPLASPALAASQGYAVLKKGVLDEEAVVRRKMAFLIGTLVMQSGEKYEGEIPGEVVNLLEANMKETEKNGPNETLLQGLKREGVLSALLEGLKSSTEDVEYEENAVRALVRAAEKDGLTAEEKAALQSIWVGWGAKGQEERGLDGQDGQEISAVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZ40</accession>
    <name>A0A1E3JZ40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="AWGH01000004">
        <property type="protein sequence ID" value="ODO05162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019033817.1">
        <property type="nucleotide sequence ID" value="XM_019174010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZ40"/>
    <dbReference type="GeneID" id="30191063"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO05162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="406" mass="45762" checksum="71D78F64A6CDA32F" modified="2017-01-18" version="1">MSVADPSPSLDTAPEDWPYTAEGGAHIVFSYGGPSSPAYDGKVLRLRKPNCPLPSSDHQTLQNKWRYELIPRLLPRELLAESREVIVEAGWFRELLILADKVRPDSRKQGVVLADMVETSGNGLLMDDATAVVKEGLESLAVEIKPKWGFLPSPTHMCPPESVPIKSHISRFTLHRHLKGHDDEKNYDPLDLFSGQEQRTERALDALWATWETSHGKGNNWRVFVNGNETHPDQASELFSPKGTLSAQTSSFFIPVLLSSPALQKLKSLQSTLDPTDISHIATLFHAAYPNAPLFDPELIPDITLAELEEFLQLYLSDPEAGKDVEKWDLRQRMVAYTLSAIFKDCSIFVKVVLHKTPEEKWELVQGRSSVKVIDLDVKPIKNMKRWAETDEKIWKYWMSTKGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZG6</accession>
    <name>A0A1E3JZG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_01405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034273.1">
        <property type="nucleotide sequence ID" value="XM_019173568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZG6"/>
    <dbReference type="GeneID" id="30190618"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO06173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="331" mass="36138" checksum="43E5921D68F12FCA" modified="2017-01-18" version="1">MAMLKNGEPSTRPQPPPKEGSIPIYLVNGIATIWDAQTAATLHCEYGISGLRAGTLPGVSQQNGFLGLPMTLMQEETAFLLQEGIAHIVPLNPTPGPPSKATIAAHTAARIARVRALEEKAAAEEVKRQAESRKLFDHGGEKARLKREARAKAKAEKAKAAGAEEPFEQKDVKEVKEKPKTQTVSPGHFHIVPAHPVVSSEASSSSTITSLPHPLFPFPSTPRHHALLSAFSRLSSLSYRVGLGPRFGGEWLVYPGDYLRYHAHFTSQVIVRDEPIKPQEIVAWGRLGTGTKKAGLICCWDDGKRGDEAVDEDREKEGEVEFYSLEWANFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZT6</accession>
    <name>A0A1E3JZT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_01563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034431.1">
        <property type="nucleotide sequence ID" value="XM_019173726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZT6"/>
    <dbReference type="GeneID" id="30190776"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODO06331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="191" mass="21769" checksum="89AEB620A6432C70" modified="2017-01-18" version="1">MRIFQCAVMGSGGVGKSACTVRFINGSYLEWYDPTIEDSYRKQFTVDNQPCLLEILDTAGIDQYLTLNDLFIRESEGFVLVFSITQRDTFEEVIRTRESISRIKLPSETGTKVSMVIVGNKCDLEDERQVSTAEGEKLAESWDCKYFEASARTSSNIAPVFEEIVRVMRRNTRPKQRELRAKRGGKKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JZX9</accession>
    <name>A0A1E3JZX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_01656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034524.1">
        <property type="nucleotide sequence ID" value="XM_019173819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JZX9"/>
    <dbReference type="GeneID" id="30190869"/>
    <dbReference type="OrthoDB" id="2564566at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO06424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="100447" checksum="3E66094844A95C16" modified="2017-01-18" version="1">MPPPTSHRPNPLRALFQPSGQSEILVAIFDHLTLHDIPALLRVNKYANDIFISSSHLQLRYRRAYHSLASNVSLSTPGRPSNSADEVATLLERERRLKCLRPSEIRCLHIPKGDVIGVKDNHMLVSECVNQMAIDPSDPDQENYWDGWSIWRMRDTTSFDGESRGARKLQGMWRWKFNFRGIVDAADICVEDNVIAVAYSVDHPPCESIEVGSMLKVVHRVYFYTLVPPVGTPQQPDGVFPTPIPHPDAKLPYIEVLVPARLHLHRIEVHMGAGGKVGLLLTSADHFRSNFVGLWDWKSGVSIGKLSPTAHTPVCDDFRFLGPFIVSASMKELPKPADDDFMDLFNRQPPPPPPPAKAPPPPPKPKAPLRPEKKSAKAPQTKSRASMYDDIDYDSEEDSGSTASSAPKTKTFSIEGVHWRTPEEILGRPFVPAPKNPTSVYDDIDYDSEEDILNEPIPAKPPKEMVYALDTLSHLPADRGSKPTKRRSDKHVGPGQEIVGPCTWYEEDIPYCMPLASLQLPALNTVPPFGVSESPLDVILDYCVIDTDFQAVRLAIEDFAVDSELLSGERQGLMPFVLAGSTADGLGRSMPTCCKGMVDIKMLIDKSVEAMQWHMAKAQGVDLKLLMLGTKLNKKHWRDQLAEAFVLFSKSATEDGWETDEDIYSRYLPKPKQKANQKRPGAATFSKKAKKTGYKWDRPYRVPFKDWQSAVSMRFNGRPEVSVSGTRTITIERIPNAKPVIRKKDGQMMIRNWLVMHDYSRRTYRENPLKPRQSLGGLPPPPPLDTAATAGPSTAPLASEEPHKLFNRPRIIKCPQPVPLPLAGMDSEPAIYKTSKMEDQRLWTKRIFEEEIVQSHLPFTETRTKVLFDVARPTVSALFDGRSLVVGVDQGAHIFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K013</accession>
    <name>A0A1E3K013_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_01627</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034495.1">
        <property type="nucleotide sequence ID" value="XM_019173790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K013"/>
    <dbReference type="GeneID" id="30190840"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="892"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="126"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="445"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="684"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="690"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODO06395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1142" mass="123196" checksum="9B187042E4FD11FB" modified="2017-01-18" version="1">MASITGLRLTTKLLHRPLATHAAQLHPTFCQLLRPTPAHLEWRYYSQQRPTSKRKEDENENIEDKGTPAPSPIPIHPPAAISLPSATAAVTTSQSSSGGKDPKPDASSILKLLSLAKPQWRLLSTGVVFLSVSTAVNLSIPWAIGRIIDFFAPGSEATLLFGLPLEQATGALAVVLLIGAAANSGRSICLRLAGQRTVASIRNQTYGKYLSMPPSHIEQAGVGDALSRLGQDTSIVGQSLSENLGEGLKAILGAGAGIGAMYLISPTLTYVMLCIIPPIAIGTFFYGRFIRKLSLKTQEAMGGMSKLAEERLSAHRTITASNTQPSESGLYATKVDGVYGLQKKETFANGLFQGANEVAGDIGMIGLLIYGGVLVKRGEITVGDMTSLFIYVNWIEWSLNTLAGFFTGLMKGVGASQRIIGLHALPSPIPLSIGQDLPKSNVGSIELRNVEFAYPSRPDTKVLDGLNLRIDKGERIALVGGSGSGKSSIQLLLLRFYDPTSGSVLFSNKDIRSYVPESWRSRIGVVQQDPILFGGTIEENIAYGHVGATREDVKKAAAVAHCDFIEKLPQGYATMITKNSLSGGQRQRIAIARALVGNPSVLLMDEATSALDSESERAVNAALNDLFANSDITVILIAHRLSSIASADRVVLLEGGKVTEDGTFNGLITKKDGKFRKMVEGQLARVQVGEPEKSPDPEEEEQHKIEEGKEQKEQENEKQSKEKAGVKAAPTTSSPFSQGGQKRQAHTLARRAHSEPRPFFSAHPNPLSSPIKTVYDAANAPVPSFPDLGLPSISGPGAPISAYKPLPPMTWKRLVGVYSALSKRNLTILMTLTATTGLALSPLPLSIPLLLNLTIGTLLTSAAANTFNQILESPIDAQTPRTRVRPLVTRRVSSFHAAMFGLICTVVGGTVLWYGCNPTTAALGIGNLLLYAAVYTPMKRFSVANTWVGAVVGGITPLMGWTAAGGSLWPTAEQPLLWHTPGSDLPDSPNPLIPLTLFCLLFSWQFPHFNALSHMIRPFYALSGYPMLSVLSPRLNALVSLRHAILLVPFTAVLAPLSGCVDWSFALTSALPNAIFVRDAWKFYKQTNEVRAKRVFFVSLWYLPVVLGLMLLHKNAAQWFQNLWGSKKEIEEKAELVVEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K037</accession>
    <name>A0A1E3K037_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_01647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034515.1">
        <property type="nucleotide sequence ID" value="XM_019173810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K037"/>
    <dbReference type="GeneID" id="30190860"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO06415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="243" mass="26994" checksum="90E7EB737A8FE5F5" modified="2017-01-18" version="1">MLSVSLLRPVFGTGSLATRLLSTSVSRSRKVIDPTLPVVPKVSNNSPYPIFFKEYLATNGNNYRDASGKLNMKEITVAAGSAFNALPQAERDVLQKRASDERKRTAEEYRQFWVSTSKDTKSAIEQATGKKLRYPGGKKAEKEDYKTRTGNPGKPLNPYLAFAEAVRSELLAQVDADLPPLQRSQAVAKLSGAKWLGLSDAEKEVYKSKHKEQKAIYDAWAETQTDLKKATPKKRRSTSPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K220</accession>
    <name>A0A1E3K220_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_01484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034352.1">
        <property type="nucleotide sequence ID" value="XM_019173647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K220"/>
    <dbReference type="GeneID" id="30190697"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="261" mass="28529" checksum="1264B61671E3108B" modified="2017-01-18" version="1">MFSFLTKSTEEEPLMPNNAVGPAALGLPIFKKLKNRRVVLASASPRRRDIFATAGIHPEIVPSTFEENLPHARFQGHLADYPISTGAEKAMEVYERLVKESPENPPDLVISADTVVVFPPEKDTAEGGDAHGEVSEILEKPVNKDDQAKVLGLMSGRDCEVITGVSIVYPTIEYPGFKVHSISNSSLITFYDNSPQTIQAYVDSEEGLDRAGGFAIQGLGGILIEKVEGNYDNCVGFPSAPFWRWISELDADGTFDDAWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K296</accession>
    <name>A0A1E3K296_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_01564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000003">
        <property type="protein sequence ID" value="ODO06332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034432.1">
        <property type="nucleotide sequence ID" value="XM_019173727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K296"/>
    <dbReference type="GeneID" id="30190777"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="651"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO06332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="837" mass="93469" checksum="2F808FFDBE1745E5" modified="2017-01-18" version="1">MSSFSATKAVEALIESVLSQKNSRKRKRPTRSVTEELEDILPSLPILTPTPFRWHRFDYSPSPSPLPSPSTASDESSYEKETCKKSDALLLPVKASTFNRALRIMSGLPVASRAARQAERREKPKERPPVWAESRQELCEALPYYRSFQSGLYMHSKVTFGYLLEAFPAPLVLYIMGDNDLLTLGLSRDAWASNGRVIISHGGGQCICPKLPNGKQGPPVLQADQSRSDARVDALLTAAERRTPIVLIAGEGYKELPWKLDCAYVVLGWYWISYTWVEAEPAYKGTKPPSGRDYFHRIKIRFDWVESQGDPWWDSEIPVSPLPVNQLSSTPRRPCGISSSSEAAEMILSFEQPSPKTSTHNFESYTESTPSWPGASELPISSPDLQGEDHNNLRWLYLPHLRLAKPQNLHRRSHLRSSLMPRLLPPSHPSRAPPHSADFHAHPLLPYEVVPPGPVEDWPEADEGGLGGAGEKTLWRGWVCSECGRANCRYRWEVWECQACGNSTAQLNASHQVPLCRLTDLRDTFLGDGVIRHSTGVSASLTVSRELGAVVAIYELPEAGKVYHIMPFDKQYATELFYEYQREATSKSWFQRRSLKSGSLLAQHFAFNSGVPYKYIVDTLSTPFDESPACVTKAVDRITSSVATVWGEEYQFNEILSVCYREGQKMGYHDDGEPGLGPVVASLSLGSSAMLSFRPKPGEKQRGNPDVALNITLSHGDFMIMDGHEIQRKYHHRVVPQGFRIAATARRISPAKPDVQVKAGVEAEDTGEVKYDDVVESCLGPDLSRLGTAQPVLDPPRYSSRELPQLPPLHSIFDHTLLPRRTPIQHPYPVPEPMVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2K0</accession>
    <name>A0A1E3K2K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034713.1">
        <property type="nucleotide sequence ID" value="XM_019172987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2K0"/>
    <dbReference type="GeneID" id="30190028"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="537" mass="58337" checksum="51AEB5180661A21A" modified="2017-01-18" version="1">MAPSSFPLLARVLAHAQSAPDSTAIVDVAQSLSISYAQLCADNLALTSLLSPLIREPETRVVVLCEKGYLVPLTMLSTWTAGGLSVPVLPSLPIPEQAYMASNSDARLVVCDAKNRLRAEELKSEILKENVSAEVLEVSLETIRKSSPAQDAVSELATLPQLDGERRAMMLFTSGTTGRPKGVVTRHSALAAQVSAVADTWHWSPSDNLLHVLPLNHLHGIVVALLPTLWAGATVELWEKFDGPAIWKRWINEQGLEPITMFFGVPTVYSRLIQTHATFSPELQAAATAGSSKLRLQVSGSAPLPESVKKTWEKEGGVGGGQVLLERYGMTETGIIASNGWETEKRVKGHVGYPLTGTRIRLWSEESQTPITVPDTQGEVQVSGPPITKEYWRLPEATANEFIDGWFKTGDVGVWSSEPGAEGQLKVLGRKSTDIIKSGGEKISAVEIERAILELPGMKDCAVVGVENEEWGQVVAVCLVTSRPHVSVKDLREELRSVIAPYKLPKLLKLYDNEIPRNNMGKVNKKKLVLEAFPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Y1</accession>
    <name>A0A1E3K2Y1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034780.1">
        <property type="nucleotide sequence ID" value="XM_019173054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Y1"/>
    <dbReference type="GeneID" id="30190095"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO07303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="321" mass="33655" checksum="E41299CE6C972CED" modified="2017-01-18" version="1">MPVPTTSSKVLPPGIYCPTVTFFQPTAEQELDIDQHVKHMEFLAKSGIAGVVLQGSTAEAVALDDEERKTLIRVAKETFRGLGHNGAIIAGTVGAQSSRQALNLTTDAAEAGADFSLVLPPSYYPGAMTPDAIQTFYEELADAAPIPIIIYSYPGVCSGINMDTDLICRLARHPNIAGVKHTDHDVGRIAPSFTILGGATDYLLGALAVGGQGAITGMANVAPRVCAKAFELAQAGKQQEALEFAGAISTAEWGMGKGAILGTKYMIAWGNGYKGSAAIARKPLPLVPEATKEHVRSVGEEIVALERKLEAEGWAGAAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Y3</accession>
    <name>A0A1E3K2Y3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_00965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034863.1">
        <property type="nucleotide sequence ID" value="XM_019173137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Y3"/>
    <dbReference type="GeneID" id="30190178"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="84" mass="9141" checksum="1CA17E4254C23D22" modified="2017-01-18" version="1">MPSLNAEGDDSKPEMTANPPTQCPSAALRLAGDCPHCQRVFCSGHRTPEAHNCTGMQACRDAAFQANKDRLEKERTVNNKIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K2Z8</accession>
    <name>A0A1E3K2Z8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_01089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034987.1">
        <property type="nucleotide sequence ID" value="XM_019173261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K2Z8"/>
    <dbReference type="GeneID" id="30190302"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODO07510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="353" mass="37820" checksum="39912DAEE5D08287" modified="2017-01-18" version="1">MAITHAKGYAIDSPKDYPNFYLKEYELEPLAEDRITVAVECCGVCGSDHHTVCGGWGPFQTKFVVTGHEVIGKIVEVGDKVTEFKVGDRVGVGAQVGSCGECKPCKGPNAENYCVKPVHGYNSHWHDGSEHHGGYSTHVRSSERFTFPIPEALESTRAASMLCAGITVFAPLVRNGTGPGKKVGVVGLGGLGHYAVLFGTALGAEVTVFSRTDDKKEDALAMGAKNFIATADPNFAKGHELEFDLIIVTASSNKLPINDFLSLLDIDKKLVFVGLPEEGLANITSQALSGNAASLSSSHLGNKSEVKQMLQLAADKNVQPWVEVLPMKDATKAIKAVENSTVRYRTVLTQDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K303</accession>
    <name>A0A1E3K303_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034883.1">
        <property type="nucleotide sequence ID" value="XM_019173157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K303"/>
    <dbReference type="GeneID" id="30190198"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="252" mass="27935" checksum="624554F8B8C45008" modified="2017-01-18" version="1">MPAYRLELASTGRALCNGKKPCFKTKIDKGQLRLGVWVEIPGRGGSFKWRHWGCVTPEVIKHWKEDFSEAEELDGYEDLSEDLQQKASVKNAWAEGHVRPEDVPESAKVEKVEEGAEDAEGAEAEPKAKKPAAKKGGKKAKKDEGEDGEDAEEAAPKKRKAPVKKSKKEEPNDEDVEDDAEEEEVPKKKRKAPAKKSAKAAKEEAEKEDDAKATEEVGEKPKSKVSHARYRAFGELWSTKMSGKMSGKMSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K3E9</accession>
    <name>A0A1E3K3E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_01201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035097.1">
        <property type="nucleotide sequence ID" value="XM_019173371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K3E9"/>
    <dbReference type="GeneID" id="30190414"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="688"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="901"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODO07620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115520" checksum="B15E42E605C90FC9" modified="2017-01-18" version="1">MPRRAPPAIAVAPVNTLLPPPLPSPIIQSLRKDWRWAAISQFVYTFSDAFGLLDWEIEALENDIDGDETVLVPTLIAKLLFALTYNRQINRDNAFEHLRKQYLKRLPDNNPFGTLEEPIEWATLGLGKKVEVLHQLCEWQMEDPARFRGLLKSEDDAVSWRIDPIGWDKPGNTYWLFDDNRIWIQRPLPLPPTQAKKSSLKAKRALKRARAQPPMKKSKTKPIPKKQAPPARKPKPKTPGEKKAKKERTPTPPPVELTGSRRRTAVAFYGNPTPTALALKRASGGPAATPSRVGGRATRSSGRFSAVGLDEEEEKPASRAIRSRAAAPAKAAPRAGVRSSRRHRAPTEEEEDEQEPLPEKPSRFTRATRSNKEVVEDQAADEDSELSELTDEDEPLGPSSAAAVAEEVEPEPTDVDSPLSSIPPDLDAELPKEDEEEDYEPDDASSGESENGEDEAQEEDGEEEDNGDDEEEEDIVKAAVREANAVPEGFVEWEAICITLYDYRTFPLQFASSKHPDEKALYSLLQKSICPPIIELLTAQEVEKQKAANFIARKRSSRIAEKESEREEIERRQNAEKEMVERMERTRREEGRAKREADAAEYAERSREERLREREERAQAREEAALKKAEEELNAKEKAEKSREERKRRRKAGEEGSETPEVENQPQPQEAQQYGRGHRRRADRWEVACEVCRTHGWNIDGDRDMVSCDQCGRWQHVECHDRLDGSVGKVRRNWDQVEFKCQDCAHRAAKRPRIDTHSNGHSHSHSHHSQSSAQPLSPYPILPGSAPGPPPPIDPAHPPPPPLQPGQFYLPYQGHQGHAGKEERPVGYAVYYPPGHPNAGERRISGGMDGRRVSDGYGSSGQQPPEGYRRTSQGYAPHQQSPLAQPDYLPSHGHPQAYPLGHSQPHSHQPPSHHYPPPGQGYASQGQSPQAPAPRLTLPPLHQQLPGQNLPSSRYPPALSAHPHSQPQHHGAPHLRQHPGQVYAGEGYPPHGAYGHGPGHNGHVVAYAQGQPRDPRLQQSPPQASVHAQRPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K457</accession>
    <name>A0A1E3K457_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034804.1">
        <property type="nucleotide sequence ID" value="XM_019173078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K457"/>
    <dbReference type="GeneID" id="30190119"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="223" mass="24980" checksum="ED3AA9B52A0EF2CA" modified="2017-01-18" version="1">MSRPNTSLAYPEMKELLNRNLRWSKRVWNKDPEFFPHHFPGQRPEIMWIGCTHSNLRQTTIMGCDPGDIFVHRNIANLYSPQDDSLNSVLMIALLNFRVKHIVVTGHTNCVGCLTALNVARLPATPPTTALQRYVRPLATLARTLATPEGPPSLDLLVEENVVQQVKNLLASDVIKNDWKKRGPDGVVIHGWVYHLEDGTIRDLNVSVGPPGHVPGKVINGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K4R3</accession>
    <name>A0A1E3K4R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000002">
        <property type="protein sequence ID" value="ODO07232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019034709.1">
        <property type="nucleotide sequence ID" value="XM_019172983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K4R3"/>
    <dbReference type="GeneID" id="30190024"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO07232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="368" mass="41123" checksum="CB5664F824743FD7" modified="2017-01-18" version="1">MASVVTHLIIDNYTDVGTVRLGKSGLKVSKIILGCMSYGDPEWSGWVLGEKEGIEQIKYAYEQGINTFDTADTYSCGASEEILGKAVKEIGCPREAVVILTKLYMPITRGSHKRPPVLGVLDKKGFVNQYGLSRKHIFDAVQASLERLDTGYIDVLQCHRFDYNTPIEETMQALHDVVQKGWVRYIGMSSCWAYQFHAMQNYAINNRLTPFISMQNFHNACYREEEREMIPTLQMFGVGCIPWSPLARGFLTRPWQNAEENKSTTRAESDALFKSSGFSAPEAGKKRVNEAIAAIASARSVSMAQIAVAWSISRPFVTAPIVGTTSLDKLKDLLEGIKIELTEEEKKSIDDAYAPQVVVSENDIQRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5M2</accession>
    <name>A0A1E3K5M2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THO complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035331.1">
        <property type="nucleotide sequence ID" value="XM_019172389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5M2"/>
    <dbReference type="GeneID" id="30189419"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="750" mass="83755" checksum="35A66C19BC39FA54" modified="2017-01-18" version="1">MALHQPLLQPLQDLAASCPPNPQHSGPISTQELTDKLSSIWHSYSISPELPDGLAKNPDIVRSVLELIGREFVVLAVINGQLPEPSEDASEKDKQVFQVALQDRLDIILTLYEVAFIANQESPSLEPGALFIPLLEELVELLSITTWRRLWSYIETRSKRYTKGMLPSRGKSLPLLRTINAFLRFLPRTPSDLVFRGRIHQFASSVFSVADKSAINMRGDYGEVKTVWEEEEAPSEDIKVDEEVKEETEEKGDVDMVNAEEKEAAPQPLTPVAPPEADFYSTLWSLQRYFAHPPSLDGPPVGSPPQTPFQTFRQKSGLVLPRLFEETQKEKELSGKDETVGKKRKREDGGFFHPRYLTGKRLFSYELLDPSFRRQILVQYLILFQFLLNLTPAHAGKQAFTGGMPRSFVLEKADEEWVTAKIKEIRGEMKKMSGGAGFEDTIFSIIRQEAHYASWKNDGCPEGAFEIPPLDASSSAKSASEDWSRRLNAPYPYSFKVGSRSLSMLWSNGFKSIDQLKGKAPATTVEGLDELIRKMEEDEEDDKAMGQVDPEKLAANKERKTTANWRALRLASQTSLKHFPALKQQRSIHLLLETIKQSQEPKAQAPKDGQGEVKVGESEEKEGEEEQKEIESQETAGDGKEGEVEGEAKDEEAKDEEAKDEEAKDEEAKDEDKAGEGQAPAEPPVEKEEVGEDKPEELRETTVDSAVTTAGGEEQTTAQIEEPEAQGEEQGDLDAKEESPQNGDVVMDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K5Y1</accession>
    <name>A0A1E3K5Y1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035282.1">
        <property type="nucleotide sequence ID" value="XM_019172340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K5Y1"/>
    <dbReference type="GeneID" id="30189370"/>
    <dbReference type="OrthoDB" id="10382646at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="237" mass="26496" checksum="0E0D80C1D2C0BD37" modified="2017-01-18" version="1">MILALDPGDLNLYMVEDLGRECCSSPSDDETDDADDVSSRDSETCTSSSSPSAHGSTSAALHLQSYQSPTPTLEPSHTRPPTCSRKPYPLSRNISLEDDTPITMPLPSRRIYLIYHIARLLLQQGIDGFFVPDGTMVDSKAEGQRRLIDINSVLRGMVYDLAKCLEQLLEPGFYIRTWACLDKQHFDSIASDFWGLSMVKKYAGKQVKIGKRFVAREKEQATKAPVRIKQIYTNVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6L1</accession>
    <name>A0A1E3K6L1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_00434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035556.1">
        <property type="nucleotide sequence ID" value="XM_019172614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6L1"/>
    <dbReference type="GeneID" id="30189647"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODO08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="375" mass="39880" checksum="58D0DC23DE027413" modified="2017-01-18" version="1">MAPNGTAAQQAVVCHAGLDLRVEDREIPAPKPEEVQIKVAMTGLCGSDLHYYLHGANGAFKIQKPLVLGHEACGIITSLGSSVNPALNLNVGDRVAMEVGVYCKACKQCRRGRYNLCAKMRFASSAKTFPHLDGTLREVMTWPADLVYKLPPDLELPLAALAEPLSVVLHAYRRAQLTPGARVLIIGAGAVGLLTCALARASGCTSVVAVDIEQGKLVFAKEQQWATDVFTLPKGPRVSGLEALEVAGGHWEALQKSQAVQSVEGLEDGFDAAAAIGTKVLFVGMGTKVLSLPTGPSLLSEVDLIGVFRYCNTYPDALALLASGKLGDVSKMASHYYALEDAEVAFEDLKRGKDKNGRTVIKPMVGNLELCGIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6U7</accession>
    <name>A0A1E3K6U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_00653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035769.1">
        <property type="nucleotide sequence ID" value="XM_019172827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30189866"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130801" evidence="9">
        <location>
            <begin position="17"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="934"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODO08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1293" mass="140266" checksum="021887A1486CD8E7" modified="2017-01-18" version="1">MLILAILLATTLSAWATPLQPTFSSCLLETSPIAAAENLLDVNDVYASLVPGRQAKELGLVGNGRDVLRLDLVGVTGAVLNGYDNTTNKLATLFTDTHAASFSVYSTTSWLCNSLFPANLPTPYYPYNTTYCPLAAGDFAVNVSIPLYRSYALTTLRTRIRVVDTSSSAANLACIDIHVSPYERTGWYYELFLYLPVAILLGFWLVSWGARFVTGWIVGSGVAEYGQKESAGARLVTGGSSRREATMRKWGTMIISGLSGERLSVSGGLLRFVTPGVRDILFHIQYAAMLGMISVQWPEFSYPIFAQGAWAHLLGNTTIVQSSDSERIDTYPSNYTPSLAFSGQMSDSQYPLYMDDTAFDPLLDLHHSSRGMESFATAVGLRVQDLFGTCLVIFLCIAGAVLVISLTLWFFHGLMEYLFGGSKHGTPVGKRATLGTSPRPSLGGKETLEGRNASSTDMLGSLPTQSAFFSHKSSSPGHLRRIWLRFRPRGEAGAFHTAALYGNLIRLILVFHLPVTIFSMYQLCLGSQASIVSRVFAALAFAFISVLFPALILWKIYKTPTGKLYDATRTLLSLGPMYNIYVEKKQMYRALTLLASLVVGIAVGAGQGSGLAQAIVLIIVELVLLIVPGVWYPWGEGASMGAPNALLGALRLISVVLVMLLAKIIGMSDTALDWIAYAVLILQAIIFVFFLFMLFTKIIEGSIRLFGGVHFDESTHPLDGGIFAVIMDLDCLNPVRGGKAAERRRRKHGSRQLQKNVYEAGSLSTQMMLDRHSQGVPRQATAEQSTPFLYPDQPPLGPPPIERQSSDRRSFESRSEERHGEANIMDAWRPAPGSGLGYAPPGMYAPQVSSPPISPVPNPAYGTGNAPSRSFSRVRGGRSNFEHPYDIQGPASSGVPVMTAMAMPTPTIKVSQAGQRPMSPPHNRQYSSSALIEMASSPQNTPPSRGIELPAAYPTSPPAQTPQGIRPDRQGQRPPALAIPKRRSLNDIKQDSDMSTDSHYSEHERKKKKGKRRSAGWFHRNETRTGDSESEESSDDEPGPSKRKTRKAALVAAQMREPEPFEDVSNLEPQPPAWKRMLGMKKKLGEEEELERDENKARKAALATESGSLFAGVQAPKPSPKKGFVVRRSGEGGPTYVPMAAPASPPGEPQSASTSFRVKRMGQPQQTPTPQRVDSPTEVKSVHASPSSQYLPLSAAGNSTGRSSGESTGEKKGFKVIRPAKSAAPSPAASSTGFVVNRRSSPLVTPTGESHPVQTGYPPSSFVPMGRASLEDGRPPARPMKNPRRSSESQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6X1</accession>
    <name>A0A1E3K6X1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_00673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035789.1">
        <property type="nucleotide sequence ID" value="XM_019172847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6X1"/>
    <dbReference type="GeneID" id="30189886"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002132">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODO08934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="325" mass="34560" checksum="E6E1AC9DB4C58595" modified="2017-01-18" version="1">MAERIETPVSKRLSSVKNIIIVLSGKGGVGKSSSSVQLALSLLALNPTNRVGLIDLDITGPSLPRMVGLDSPTATVHQSSAGWVPVYVDQGRRLGVMSIGFLLKDRGDSVVWRGPKKDGMIRQFLSEVRWGELDYLVIDTPPGTSDEHISLLTHLHPLFTPTPSSPTTPSSILITTPQTTALNDTIKSLSFTRKLSLPVMGLVENMAGYVCPCCGEISDTFGKGGGEALAHKESVNFLGRVPIDTILVALLDAVSKGEVQGEGAKETNGGDQAASSAGFPLLEKYLETTSSKVWLGIADKLVASIVERSEKITERLGPQEQVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K6Y5</accession>
    <name>A0A1E3K6Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_00697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035813.1">
        <property type="nucleotide sequence ID" value="XM_019172871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K6Y5"/>
    <dbReference type="GeneID" id="30189910"/>
    <dbReference type="OrthoDB" id="2576231at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODO08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="371" mass="40162" checksum="055F6900852C0803" modified="2017-01-18" version="1">MSHPVSPTPPPQQQSASALANSLFQSDDGLIAYLQHNTDYSQDAAGNYTHNSQVGARSPSPPLPLPIPPSLNRLASNALSGFHSPSLQPLPAPVDQAQVAAQMDYGDRGEMGGKRRKLPHQRAGWAEMEQQSGKKRRISRKSTEGSPGPSGSPSSAIPQHPGHTPGSSGLHVDSPSHGAQDITSLTELSQMAINGQTAGVDVGHVHVQEEPQIDPTLASAQEKEPVGPPPPPEPPVDNSKLSRAEQNKRAQQAFRRRREEHMKKLEAESAQLQVVLRQCQDKDAVIKDLVMSQQTDKIRIAALETFIRQNATTHGSTPPFTGTGELNISEDLTFPHQSETGVSQDQLENAFQMLERQSRQVVKQLNRGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K798</accession>
    <name>A0A1E3K798_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035651.1">
        <property type="nucleotide sequence ID" value="XM_019172709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K798"/>
    <dbReference type="GeneID" id="30189742"/>
    <dbReference type="OrthoDB" id="2552978at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34320" checksum="7B728A6AAAC72BAD" modified="2017-01-18" version="1">MPHPQKRPHPRPSTSKSTAPPAAYGQAYEASLVYGQDHMAQSVRERGGRGGLIQYAGEADKEVWADRHDMIHLLPSLPSEGRNIFIKASSLTRSSSSWSLPSDTEETWALSDEEEMEVYKNEKKKKWMEGLRAERLREREREDMDRGKAVQKSADGWDDDEEPPEAILTLMAHTALALSGSPNPSVLEIRILTNHSNDERFAFLRGRYRKAWEAAKGKVKREKEEKARKEERERGLGGLGGYGSDSESESEGTPEPPHDEPPPPPEDDPLPPLPPADDDEEEKKRQRRLRAEEWKRKRAEAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7G6</accession>
    <name>A0A1E3K7G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_00601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035721.1">
        <property type="nucleotide sequence ID" value="XM_019172779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7G6"/>
    <dbReference type="GeneID" id="30189814"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODO08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="666" mass="70741" checksum="D037F11E4294F8B2" modified="2017-01-18" version="1">MESALSPNTTALFNYLSSSFNNDQSNNPTSLPTAALFNSMPVPARDTPEDTPPSAPSSSEPLRHASADEESDSTLDRQNSTGLSTGANVRNKRKAGQHSRVAEEDEEEGSESDLPSGHEDKRQNGKGRTASGASGSGRRGGRKSLTTADGEGRKELSKSERRKEQNRAAQKAFRERREAKVKDLEDKVSELEGQAYGAQIENENLRGILKRLQEENVALKQSAFTFSMPMSTPASTNAPQPQNPKPPTPPHTNTEDSLKSVNDMRPASHRNSSAASLFKDSPESLVSVGSGTDQTPPNLFPDHFNAFALGGVGVPPKDPSVPTLAAQHQTEKKVSPPSSVSTAGDSEFAALWSSLYPNGVEPAVNQNSSDAKGGPFQLLNSQPEFMSFTNAGFGFSDYFPDSASAMETDPTPPPAPAAPTPNLGATGNTSDWNKFAFRDSSADAAAANWESGVDSSVSDFLASLTGSDNAAPQEPVGDDDAFNAQMRKIFGADNSPSAAFNIGTGSSTFSPNNYLNMSPSPLIQNSNGVSPESSASRSNTDSGNSPLSSNTSVSGAQKPSSGSESGDCLPANLGTCIAPGPFKKSHDIVHIIDENGRTVKPSELWIKLGMEYENSMDSLLIDDLCAQMRSKATCKDGKMQLSLKDAEEQYRHDWIKNQEAGNEPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7H1</accession>
    <name>A0A1E3K7H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035658.1">
        <property type="nucleotide sequence ID" value="XM_019172716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7H1"/>
    <dbReference type="GeneID" id="30189749"/>
    <dbReference type="OrthoDB" id="2574468at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="245" mass="26125" checksum="6E4791872A18611B" modified="2017-01-18" version="1">MTQSPFAPFGHQNMAPTAAGLKSKRKRMSWGAEEEQSGSKHMRVRSPTMQYSNYAVPDLVADHSNNASDDDQVMDMDQDMDMADSSSAVGPSSPVDNYSQGSYAYESGGSGGFGFGPGAEEDGFDDLDMMDDMGAKHTKNFPSLTPHPNPHHFSNQGTGMRGTSPLAAQAFSTGLPAPPTRGVYQPTASGPLAANATDIDRARSQHGPWCKSIPKLIMSEYPGANGKRSMWTVCSDCGACEQTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7K9</accession>
    <name>A0A1E3K7K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_00247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035374.1">
        <property type="nucleotide sequence ID" value="XM_019172432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7K9"/>
    <dbReference type="GeneID" id="30189462"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="327"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODO08517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="905" mass="100387" checksum="0D7B1A2FCB113A6C" modified="2017-01-18" version="1">MAEPATLPAFSFPPAPLSSSPTDPTSPAGLQFDTEALALTPENEPWDRELEPNMGINPLIDPSSYQPHMLNHAWSNSSLSSFHSTHSNPGLHVSTDSPIEIPSASHSRHSSYSSLNGIDTKMPWNRPPFMDMYPVQHVGEFNPVIATGDLFSASDIKQHPKLAVQTQGLGKIMTTRERSASRSMPYSRQRSESLSIKSEEGDDIASLISASTTYSAHTPWSTTNSIAGGFNDLSLHHRRTSSSTSYTNTPLRTSPPRPMLSRARRSSSMIIPRQQSQSDLSRNEFKLQGSAAERQAVVRSDLTEKADEIKGMSSSSQQDKARALWVRRCRLLMSYTRSGPHTVPRQGLYHSYTMSCDEYGIKPINSASFGKAVRSAYPGIKTRRLGVRGNSQLMIPRKYHYVSIRPAIQIEAERLNDYGDSSGAWHVAPEDGSMDFQSSNDRDMVMDGEDVDDSDEEDQKPFGSLSYRPSQQSLSRDRSTSIHELFTPQRPKAAFTRRHTTSSVNSVGFRASQSHVRVFSLPGFPTLSVAAELGNEVSMESLQSFWNSFCQHEEIIVECIRGYHFDQYEMNCRTFWNSLPPSLVQVCLHPVISSMITEAMLVCYDHIVGILLDKLTSPCPVTSQCSLRALADNLEAIMEESLGIFPQNFSESKVEMSARVAHLFLRFIDLHQLTAALSPILANQSQVRTMITAWENLDVRNVSDQCALSCQCQQDVIEAVLQDFYHWLVEAEEYLAQGGYAIDRLGGWVDKMLRDVQAATGGASLSALVCKVGFVTSQVMRDFTLKSDQTFGLFQLIKTWLDDWVSIAALRKTKLSIGNGSPPVPTYIPAMSVFIPQHDTITNPDLSTAVPFGQGSSQWPQSGLHAHHQPFDGQQGQYLAMPSFGSEHNASTPRPMFGHAMGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K7Y6</accession>
    <name>A0A1E3K7Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035828.1">
        <property type="nucleotide sequence ID" value="XM_019172886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K7Y6"/>
    <dbReference type="GeneID" id="30189926"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35768" checksum="8C898D3D11C84C53" modified="2017-01-18" version="1">MPPQIPPFDSLPIDKQGPPYNAWGLYGPDDELGRLNLITAESVKRGKNTITEGIAINLNLPLSFFPAHASRKRLEHNIKCSGHSNDDELALNTQTSTQWDGLRHYPYQDWPEKGQYRFYNGMTLEEASDVNVKKLGTQNYVNHPITSRAHLLDIPHHLSTRSLPPLSPFSSTSSIPLPLLKACAAESNIHLLPGDILLVRTGFAEAILELGEEEREGLRRRDINGSCGVGKGEDVWRWHWENGIAAVASDCPSYENWPTPSQLTSHQIFLAGWGLPIGELFKLDELAQKCRELGRWTFMFTSMPLFVEGGIASPPNAQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K949</accession>
    <name>A0A1E3K949_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_00505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035627.1">
        <property type="nucleotide sequence ID" value="XM_019172685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K949"/>
    <dbReference type="GeneID" id="30189718"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODO08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56056" checksum="8BA904505432312F" modified="2017-01-18" version="1">MLKSEAEVPNITWARTYSTTFRYRFVLGVPRLVTIDPSTINYVLSHPELFPKPDHVKSDLISLTGGGLLAADGETHHRQRRLLNACFNSSAVRGVVPIFYDKAYELRQKLLDLLDGACAETPSFTPPQAIDLVEGARKIDMVKYLSRTTLDIIGLAGFGYDFKQLQEADTELSRPMKSLYAIILRPSILSILQTRFPLLRSLPTARMRAVKKNLKASRRVGERIVREKKAEALLAGGLFEKGNTGKDLISLLIQANMDDSLPAEQRLSDREVVDQITTFMAAGNDTTSIALTWSLRQLVLSPTIQDRLREEFSTIIDDRPDLETLNALPYLEAFIREVLRHSPPAPSVFRSAREDHIIPLGMPILGRDGNMIHHIKVPKGTSIQFSIATINTSPIFYGADAADFNPDRFLDSPKKRKRSEVPGVWGGSMVFFSGPHHCIGYRFALAEIKTILFVLLKNFEFAELPSKPVIERKAARVMRPRVVGEEKYGPQLPLLVKALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3K9D6</accession>
    <name>A0A1E3K9D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_00596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000001">
        <property type="protein sequence ID" value="ODO08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019035717.1">
        <property type="nucleotide sequence ID" value="XM_019172775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3K9D6"/>
    <dbReference type="GeneID" id="30189809"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODO08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="207" mass="23413" checksum="8AC592972F56F4B7" modified="2017-01-18" version="1">MLRTPLRLALRLPRLNAITPQRRFAHALPTDLPPIRARLRPLVPFFIYWTIITSLLVHLLRTRQESGESLSRQKAKISVLSDLIARIRNGEDVSEDEMQREMEMVGLRERTALTLGLDKELKEAENVGWREVLLGKTAQTEEQAAREEKAIEEWAQLMDGSEPQAGPEAEAEARAPSIRSLLRPSERRQEGGREGMASRAPGSSVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HB97</accession>
    <name>A0A1E3HB97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_08295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000067">
        <property type="protein sequence ID" value="ODN73607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027763.1">
        <property type="nucleotide sequence ID" value="XM_019180260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HB97"/>
    <dbReference type="GeneID" id="30197505"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="153"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN73607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="380" mass="40390" checksum="2A3FF8EB74C27AC3" modified="2017-01-18" version="1">MSSPSTSSENSQFTTPASSLASPLLSSTHITPKPKVLLIGDFCGIPKYDNLIREIADVHTMPRCGYTETAALIKQKVEEEGSFVAFGGLFVITDNFPSLWDAGLLSPLLPACRLFVGPGAGYDKVDIPYLSSHGALYANSPHAVGERTADGALGLVLAAARGIVRYDIGVRSGGWRDVGVKSVDWRNAKIGIVGLGAIGLRLSTLLTSLSSTLQIHYHSRHLSSSHLATSYTYHSTLSNLLPVVDILVLTCPLTKATEGIIGEEAFKQMKDGVIVVNVSRGKVIVEDELVKALESGKVLRAALDVFENEPQVHAGLLSNPNVTLSPHVAPAPDSMGPALNAEVLENIIHYLQSPSGLPLTPVNVDQVEALGFTTGARREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HJ69</accession>
    <name>A0A1E3HJ69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_08086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000052">
        <property type="protein sequence ID" value="ODN76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019027959.1">
        <property type="nucleotide sequence ID" value="XM_019180058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HJ69"/>
    <dbReference type="GeneID" id="30197297"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000053">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="152"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="905" mass="96229" checksum="F6221C7C9A2B2671" modified="2017-01-18" version="1">MVHDTSEPPPPPDICDSRPYSNQISAFTAARSTTSVIHSDPYSADGKDGDHSTFTLLSTSNIQQYGRQQSSQPKRMARGAFAPLALVFLLALAFLPIASATGSEVDPYTSYPPMKATPLLSSLAWVYNHAVSALGIDPAVIAAHAGNTKRSLDKTGIVEACMIPVLVLLSGMFAGLTLGYFSVDPTQLQVLSISGTAKQQEYARLIMPVRKDSHLLLTTLILGNMIVNEALPVVADGVLGGGIVAVVISTALVVIFAEIIPQSICSRYGLLIGARMAKIVRVMIWIAFPIAWPIAKLLEYILGAHHGIIYRRSELQELIKMHAASGEGGGDLDFDTVQITQGALNLAKKSVKEAMTPIDEVFMLPIEAKLDYETLGQVVRSGHSRIPVYQTVEVPDINFAAPSVGPAKTKMVKKVMGSLLVKSCVLLDPEDATPLASIPINTIPTIPFDEPLTNMLNVFQEGRSHMAIVSRRAKRVEPEIEDAQSVMTAAAGGLREKFMRKMGMGGSDSESSDDEVDVEKGEKKKKRRMSKSKKRRGSGSSTDETAVGPTPETAPATEASEIKRKAQDEELKKQKSREGKEKKGSLVQAAKLTQLEQTVPADAQMSNQAVEKFFDGLEGAPLGIITLEDVLEELIGEEIYDEYDQHGAPLSAASAFVPREAMLAARKATLARQQLAVAQSTPLPPTNDADIETAAPAPKGRVMGKLPALSKFSLKKPLSQPGRARTLDVTTTPSGTPPPSAAGVVATPAEEKASFARGTVASPAEIEDKPARRSSAPFDTAETATAVPARLLPGSTTATTPAPQPKLLNEALLIERERRRLGTASQPTAHRSVSAGPGGSRQATPPMAGEARLAPPVSGAGASTSGQGVVSPQPHYAGKKVPKFKSVPTPIGTPPIAEKKRSDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HP34</accession>
    <name>A0A1E3HP34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_08001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000049">
        <property type="protein sequence ID" value="ODN78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028035.1">
        <property type="nucleotide sequence ID" value="XM_019179974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HP34"/>
    <dbReference type="GeneID" id="30197212"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="330" mass="37642" checksum="E113B6FB8855656F" modified="2017-01-18" version="1">MPEQSPERPLPSTEATHDRPEPEHTEAPPTKRARPNRDDKARGKRLFGNILGTLQKFQTEDKSTRGSEAARKREEVSERIAKKLHQETALNHEITETDRELKGLKIATEHAETTLRQKDISIGARHSLLQSTAKFLHTRLPLPHPPVFEGGLFNPAPLPISVGPKREPPIKTDLPPLYFLPKILLPHQQGTIASQTTNMSERISEEQASLETERQHVRTLAKENRARIEELSEKLGGLRRQVRPERADERITERDRGHMRSERSAAQREPRRARGGDRDVGVDELGRTRREDMMDIDQDKEEGDKAVDLRDEREKGVKIQGDDGDIEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HR55</accession>
    <name>A0A1E3HR55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Immunoreactive mannoprotein MP88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_07965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028060.1">
        <property type="nucleotide sequence ID" value="XM_019179938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HR55"/>
    <dbReference type="GeneID" id="30197176"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009129303" description="Immunoreactive mannoprotein MP88" evidence="2">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="33831" checksum="39BEC8B6685A4FA9" modified="2017-01-18" version="1">MLTSIPSLLPLLPLLPLLPAALAQYTATYSPGSLPDSSEEGQYGTNACGDGSAYCLKSGYGTRLIPEGTLTGAHFVKVQSDKVSYVQVTGKGDLTKLLIADGDEGGELDVPWTGLGNPQGGLVFTNAFSGSYEQTHEWTSFMSSDEFCIRACQDGDNAASYCQHIYDLLGCGFTIPGSTSDGFDACLAPPTDEAPGVYDGTTFYQGDATTPAAHAAAETSECQYYSSVGGNGVWNKRSEGGEGEEKREEMVVSVTSTVTGKATTTTVFSTAPATASATASTTPTALKANASSSSSSSSSSSLSGAGPRAFVVGPVMMGGLGLVGLMSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3HR64</accession>
    <name>A0A1E3HR64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000048">
        <property type="protein sequence ID" value="ODN78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028070.1">
        <property type="nucleotide sequence ID" value="XM_019179948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3HR64"/>
    <dbReference type="GeneID" id="30197186"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="300" mass="33293" checksum="EC504AADCDE2E6FA" modified="2017-01-18" version="1">MPFTEVTLNDGRKIPAIGFGTWKVPNDVTAGEVDQAIDIGFDHIDTAQMYGNETEVGQAIKESGLSRKDIWVTTKWSGVDNKSPRQSILESLEKLGLEYLDLYLIHHPRLAKGDIRGTWKEFEGLKKEGFVKSIGVSNFTKEDLQELLTHATIKPVVNQILLHPYVISTQGPLLSYLSQQNIIPEGYSSLIPLTSKPGGPVDKPVGEIAERLGKKPEQVLLAWSKAKGAVIVTTSSKKERLESYLDVGDITLSPDDVHAIDKAGIKGQLWEERKERLVKASKWAVPVYIGFWVLFKAFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3I9X2</accession>
    <name>A0A1E3I9X2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L198_07530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000036">
        <property type="protein sequence ID" value="ODN85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028470.1">
        <property type="nucleotide sequence ID" value="XM_019179524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3I9X2"/>
    <dbReference type="GeneID" id="30196741"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000028">
        <property type="entry name" value="Replication factor C subunit 2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODN85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="346" mass="38670" checksum="27D06C3FA876FA64" modified="2017-01-18" version="1">MASSSSTLPPPPATAKHADAEGYEMPWVEKYRPVLLQDIVGNSDTIDRLKVIAEDGNVPHIIISGMPGIGKTTSIHCLAHALLGDAYKEGVLELNASDERGIDVVRNKIKTFAQRKVTLPSGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNMSNKIIEPIQSRCAILRYGRLKDAEVLKRLKEICEMEKVEYNDQGLAALIFTAEGDMRQAINNLQSTFSGFDFVNQDNVFKICDQPHPITIRQMIKDCQDGKIDEALARVNNLWEQGYSAVDIVVTIFRVVKGMEELPEYLKLEFIREIGWTHMRILEGVGTLVQLGAMIARLCRFSLPPKALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IBX2</accession>
    <name>A0A1E3IBX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_07595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000037">
        <property type="protein sequence ID" value="ODN85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028443.1">
        <property type="nucleotide sequence ID" value="XM_019179586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IBX2"/>
    <dbReference type="GeneID" id="30196806"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="79"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN85271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="547" mass="59380" checksum="67F7ABA361BF66C2" modified="2017-01-18" version="1">MSSSAPDCGLEKGAFAPNQHHVSPDRPETPESIAVPRPIQQDLSTSSSPSISEETAPQTTEEPNPPPYSAFSQSTKYLIVGIGAIAAIFSPISSNIFVPAIPTLASQFHRSESDISQALTIYLVFQATTPSLFGAMSDSFGRRPLYILILVIYFAANIGLALIPTSGYAALLVLRAVQSTGGSAVVAIGYGCVADVAEPRERGTFAAIFQTGALLGPTLGPLLGGILTQTLGWRSIFWFLVILTGVILVPLIFLLPETLRSLVGDGSIPPPPLNSTPIQVYQSNKTSKARAAAGLDTEKYQPLSSLMLLLIPEIILVFFWSSLIYMEYYASIALYSTALKDQYGFSEIKIGLCYLPCGFGTILSTILNGKQLDYYFRREERRVGGDYSSHPHTFNTERCRLYCFIPYTVVGLVAMTAQGWCLEAGAPLGGVLVVNFFVGLGMGVVTTSTMYAQDICPNKGGAISASFNLVRCAFAAIGTATIQMMYETLNAGWTFVLLSGLVVVFMPFPISVVRYGRRWRAARERKEEGKKQRVEEREKGKEKEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ID34</accession>
    <name>A0A1E3ID34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000035">
        <property type="protein sequence ID" value="ODN85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028512.1">
        <property type="nucleotide sequence ID" value="XM_019179474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ID34"/>
    <dbReference type="GeneID" id="30196690"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="284" mass="30951" checksum="931F3C9442C6C0DE" modified="2017-01-18" version="1">MPLPASHTKHLPVIHHPLPNHLSIELPVRQISSDSSSASGSTGTTGTTLWLSAQVLSAYLSSLPVPSGGKSVKVLELGGGTGFTALVLASLGYQVVSTDIEPVLSSVLGPNIDSGKRVLLGNSLPANISPRFLDWAHVDRLFKGQEDAPDDEWLKPEGGWDMLVMTDTFYAPHLIEPLWNTLIYLSTPPSSTITSKPPPIYIALESRDPILIARALETGKAKGFELKKVGKRVGKEVERWGWGKDDWEGVEVWKGRYKGWKCVSGMGGYDIRLYDLPSVRQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IE61</accession>
    <name>A0A1E3IE61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000030">
        <property type="protein sequence ID" value="ODN86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028841.1">
        <property type="nucleotide sequence ID" value="XM_019179224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IE61"/>
    <dbReference type="GeneID" id="30196425"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="59317" checksum="A37470853658F9CB" modified="2017-01-18" version="1">MAERSRSPTVLYDIERPSSPSSSSDFSAILNHKRHWAHRALRLDFPRPVHVALTCISITASAIQANGVYCWGTYGPVVAQWKKLDGTEAQTIVVGGIVGVYLMAAPLGWLTDRYGPRVGSLISGCLSAAGYLSFAAILDKSTPETPALYLWLTAAFFLVGAATVGSYFACLTCASLSFPSHPTLSLSLPLSLIGLSSLAISSFSTLPTFLSPETHDLDPVKFLFFLGVLSPAVNLFGFAFLRIVPPASPHKSLHTHLPGDAPDSDADSDQDPSLDPLSASLNLSEHTPLLIGGPRSALDEIEEDQARGRDVAWGLRELIRDWKGFWVFGVLCALVVGPGEMVIASIGSILTSLLPAPTSLLSLASPNPLKLRNKHVFLLSLSSTLARLITGILADYLSPPPTPFKNPEHTPGDPTKPEHVLRQVKKVRLTRSGFAGLCAGVLAGVFGWGGSGWLRGESGLGVVSVGVGAMYGALFTLTPAIVSHHFGPTNFGLAWGMISYFAALGSVIYSYLYALLSTPGTETECHGPHCFRVTFVVCAVSCVVGGAGLALLGRRWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFL1</accession>
    <name>A0A1E3IFL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_07026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028962.1">
        <property type="nucleotide sequence ID" value="XM_019179044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFL1"/>
    <dbReference type="GeneID" id="30196237"/>
    <dbReference type="OrthoDB" id="10301533at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="148" mass="16431" checksum="86C721942CA7F2AE" modified="2017-01-18" version="1">MEQYLQNLRQQSESYPASSAGTASSREQRGPSTPAETATGECITIRFNNQQTGSTTTPGFLPLYPPRSRQQSGESGYVWSVGITREGGRSVTDDRQKIPLSSAIEEWLEPADQGRRDTLNYLIEIDLQKSFATGQQDFDHTAQNDRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IFN5</accession>
    <name>A0A1E3IFN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_07031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000028">
        <property type="protein sequence ID" value="ODN87407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028967.1">
        <property type="nucleotide sequence ID" value="XM_019179049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IFN5"/>
    <dbReference type="GeneID" id="30196242"/>
    <dbReference type="OrthoDB" id="10383974at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN87407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="116" mass="12710" checksum="B37FC0B7B9B349BA" modified="2017-01-18" version="1">MDYAQHQLNMLAHHLPSQMVPNTQQQPAPTTVMTKPERYYLGGAYLRPSYPGMGLGPMYIGRYHPNIGYVPSNGMMMGGHGMSNWCPGGGMYGSFGMGYRGYGGVVDPMGTYPFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IHB3</accession>
    <name>A0A1E3IHB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_07133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000029">
        <property type="protein sequence ID" value="ODN87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019028905.1">
        <property type="nucleotide sequence ID" value="XM_019179147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IHB3"/>
    <dbReference type="GeneID" id="30196344"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="232" mass="25360" checksum="90AB77C2B67F34D1" modified="2017-01-18" version="1">MSGLALPKGPQAGPSNSNNAPDGRQTLAGAGDVATRQPQKAVASVPEITAVDGLVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPRRFAAVVMRIRDPRTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFDAKFAEFKIQNMVGSCDVKFPIRLEGLAFSHGAFSSYEPELFPGLIYRMLKPKVVILIFVSGKIVLTGAKVREEIYMAFNQIYSVLLEFRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IJJ2</accession>
    <name>A0A1E3IJJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_06891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000026">
        <property type="protein sequence ID" value="ODN88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029194.1">
        <property type="nucleotide sequence ID" value="XM_019178917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IJJ2"/>
    <dbReference type="GeneID" id="30196102"/>
    <dbReference type="OrthoDB" id="2681567at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="384" mass="42507" checksum="F7DCD93093927DA0" modified="2017-01-18" version="1">MSQRHISAQAIKDAKAAFPPGQFTRGRSESDDEDNLPPTLASTSQSVISVDDDSNDEGGKDVDEDEDGDGEETTFSVNSSTSTLSRLINRTASHCEKYFSMCKEKTLAPHHKILDGFKSEHENVVGKNGSTIQDYLKPASRKKPSFDDLTTFIAQWTAETNQRTAITTKIRALSREKQADLKAKLARQSGRFNLTFDGWSSSQMTSYLGVTVHYIDEDWALHSDVLGFEPIDGSHNGTNQATMLYNLMCKYDIAEKVLACTSDNASVNDATMTSLAKILFDAHFIDADNSPMRSRCYAHILGLAEGHLLNSIEKHTAPMTAEELDKGRVEKVVETRQEVETRQEVEEAENLPDKDVASEPTSVSNLPPLFDKIRKITAKVSSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IKL5</accession>
    <name>A0A1E3IKL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_06451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000023">
        <property type="protein sequence ID" value="ODN89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029417.1">
        <property type="nucleotide sequence ID" value="XM_019178510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IKL5"/>
    <dbReference type="GeneID" id="30195663"/>
    <dbReference type="OrthoDB" id="2577792at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="742" mass="81949" checksum="9691C2C3243730D6" modified="2017-01-18" version="1">MAASLEHQPGSPTTYASSFDIDTALRGEAEVDAVSALFSNKKILRKTIVSFGLAHKNRHDEPITVEAHADLLKLLLEENYNIDVDEIGEGYTQVHTAGGSLSLFDARVRQDDGRDKTYRQTIHFSRFANWSSENKELFGQDVEGRVGSRDGIIKPDGGISASVVCKFDDINNKPALVDSELVMEPNKSLTFLDHVTVGLRTQYELKDNEVLYHIVCIVIEMKPPNISKMLLIGQISCYAGGYHDVCGTSYAYAGHGPKVYRLLVLDNAIVFEGTSSDGVEVVGNFDTLKKRLEDGSDTVGRSLLVPNNEGKNQLDEELVKDVRKLCVAAIEQLKRINRDRQPLTRLPSPEGETWTTLKNMVKTFTFEDAVTQPEPFFEAARLSRKKIAELRELRKHKKDSASAGNAESGRRAEDSEFVAPPEGAESTEVNADAQPRTDVDPKRPKRNKKKTKQQFVNDPPPKNRRNRSPSPGGGGQGPTKRYPTRNQATQAGPSATNSSATKEGGQRGRRSGRGAKTAGRTVGHRVGNVRESNDNTTNVLKGKDSFESASSKESIRTPHESTVINPVMTGTYGDYDVATTDYDPLTASNLKNIGSYMPELNASEKVRSLHESMLMDPVMNGGQAHHNALTELRNIEEEVPKQTASGIMEDDIIDEEDNGSFDRAPSAVYDDPCQEYVLGDAEKRRAFNTKIQLLAARSVLRQANTIFVIAGKEIFNKCLDEATKFVHLYVHAIGLRLTQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3INT1</accession>
    <name>A0A1E3INT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029720.1">
        <property type="nucleotide sequence ID" value="XM_019178282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3INT1"/>
    <dbReference type="GeneID" id="30195428"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="963" mass="106786" checksum="DB50E340FEA80C2A" modified="2017-01-18" version="1">MPGPPTIYYGPPPGHPGHPGHPGGPFSFAAPPSGGPRPLSANGSGDSAAQGQGPWANRQLPRPQKDLPGHPAHAARRMTYQPPPSEPMAEYQEWKHWRRDQVLPQTSPHAGGLPEGSFVDRDGGRYAEPALPHMQLPPPSAKATAKRPRTESVLPPDVVQNGSSSSSRKKHTVQQDSPEFKPAYPAVLTREKKQKACSNCRKAKLKCIVEPNQTLCVRCHSRKEKCIFYPRGHDDDWQQTLQTDLYNATNHLSQLSNAVHHILHHLTASNLIPPLYPPYERYEAPDREGYFPLDKKGRDNDGDKKKRRKASKSAEEDEERPASPEPTAGVFLPPPSGPSGMFSYHQPPHTAPLPSAQIISPISARLGPTQQAFGLPMPLPTQGHAQGSDTIEQEKETPEEGPAFGSPTNRGRLTQEGEYRMHQGGYPGQGHLTLSSMRDEPLPAIESEGMFVDENGLEIAVGSMDTRTDVIKKDIVSNKDALVLINFFHSRMSGFLYGYRLQLGHFPYLPDGPSTLTPLILAILCLVTCDHFPHLAHLRSPLQDEISSALNTSPAKSWQNFDATISKDFGDLDGEGAIDAEFALGPEEIVGLCVVATWMVDRREAALIARVAFRWARGWIEVLKNQNRMMTVAEKVGIVPAERSATEQDMTRVWLFCYVVDSTERLRSPEAPQVTYRDALPNCNRLLPIATPPASHPSDPFDLLLTLHTKVIMILNEWRKQLGLLAEAVPEGNQSQMKRLVLKTNGDLEFWKANFDAVRPTGQRHGENAVLKWDYTLLTWLFTKLSVNMSLPDALAARPQNFHSYSDSALQLSPTQPQYQAHLPYASATPQLSASDTQLREASWSKAADCAMQMLEVCASWQPREELLYFSPTYLFFITLAAEELRLVLGSLEERALIDAADVVSLLRTIGESLTMGDLPPKHQTRMAAQALFYHAEQLEGPQENVWLMLGDQRQGRQGVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IP94</accession>
    <name>A0A1E3IP94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L198_06273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029777.1">
        <property type="nucleotide sequence ID" value="XM_019178339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IP94"/>
    <dbReference type="GeneID" id="30195485"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODN90255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="85" mass="9902" checksum="88521FD85220B4D9" modified="2017-01-18" version="1">MSYQTGKGAGIGTGYKRTWVDEVSTWIVPTVIRPSQDGRRALVYLDRQWREARAVQELKSLPERLDRERADGEDRRGVWLWLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IQF9</accession>
    <name>A0A1E3IQF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_06151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029936.1">
        <property type="nucleotide sequence ID" value="XM_019178217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IQF9"/>
    <dbReference type="GeneID" id="30195363"/>
    <dbReference type="OrthoDB" id="10261807at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN90834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="274" mass="30093" checksum="D3AC842932FB349E" modified="2017-01-18" version="1">MKFQYRPSEARGGADHGWLKTFHTFSFADYYDPQFQNFGHLRVINEDRVAPGQGFPTHPHREAEIFSYIISGQLSHKDTMGNVETMSRGDIQMTSGGTGIAHSEFNAHPILPTHFLQIWALPPQRGLKPAYYTRHFTDEEKKDKLVKIVAPVGTEGVVEEREVKGTTPIHSPVYFYASLLSPSKSVTHTLLPPVLKPTSQDKLIYIQLVQSSGYNTGAASVKNGAAVKVIGGGQDQVIGEGDGVFIRGGQVGEEVVLENVGQKVGEVVLFEMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IR53</accession>
    <name>A0A1E3IR53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000021">
        <property type="protein sequence ID" value="ODN90191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029713.1">
        <property type="nucleotide sequence ID" value="XM_019178275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IR53"/>
    <dbReference type="GeneID" id="30195421"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001499">
        <property type="entry name" value="Origin recognition complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="363"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="596"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="87514" checksum="9B430F039FB53F40" modified="2017-01-18" version="1">MSGDSVPGQQHPLPPPSNQNDSDEEEVLEGNACQAPPRKASLEPQSPVKNTPRKTYSSAKKSVGAVALTPQRRGRSSAPSSAAKSTTKTAVKAASKAAPSPTPNRKRVAPAEEINSEARLTRSGAKSAATPTKSKGKKAPSKTPMSTVQRGRNSLAGTPTLASGLRDGLPTPSPALRASTRKRARGEGVSKALTFGDDVFDDDEDEEIRAKKQKAEEYTREQFLQNEKQRKLREARNYQFTGDSNAPRTTRSGRAIRDTRDEVMDVEEEELDEYGGKPQDEEPLAPSAPLIPEFELSTAPLVPTSPPLALSPAPEPEIITGEPLPDDAEPVLKTILNTLNSRGITQDPPPFLDEDKNEALQGIYNLIKGTVDRGEGNSALVVGPRGSGKTRTVARALSLLPSSAARTAPIIVRLSGLAQTTDRLAIREMGRQIAEAEGRVMEEEAVDEDERGDDEEYAPTTLPSHLLALLTAPSPRAIIILIEEFDLFTEHARQALLYCLFDVVQSVRSGPVGTTPRGLAVIGITPRLDTLLLLEKRVKSRFSHRIWRVTSPLASVMQGGVGGVGNGTEGQGRGGWEVLLKMALIPWYPESVLDDPEEKWRGDWEYVVITTLGDERIRRYFDRLVGLTTDVRVLYRPFILPITRVITRLDQKLDSKILADQILAQVETSSFGLQNNKLRGLPTPCLGILIIAKHLAFAGREEFTYAMVEEEYLRFARTRLVGIGKVRWSVGVLRTAFSNLVRIALLAPTSSSTTVTNKQHPNFLKVRCTLSPNEIVEWFTEAGKDSVGPEMGTWGRTLGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IS23</accession>
    <name>A0A1E3IS23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="5">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="5">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_06022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000020">
        <property type="protein sequence ID" value="ODN90706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019029808.1">
        <property type="nucleotide sequence ID" value="XM_019178089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IS23"/>
    <dbReference type="GeneID" id="30195234"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5 6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN90706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="333" mass="34596" checksum="D9ADCB01C52DADD1" modified="2017-01-18" version="1">MFRSLRATSNIARQAAAPRGFASSSVARSYEDTIKNILVNRDTKVLVQGFTGKTGTFHAQQAIDYGTRMIGGTNPKATGQTHLGLPVFGSVKDAVRDVQPDASVIYVPPAFAADAIIEAIENEIKLIVTITEGIPQRDQIRVYQALKSQSKSRMIGGNCPGIIADGCKMGIMPGHIFQQGKIGVVSRSGTLTYEAVNQTTLVGLGQSLTVGIGGDPFPGTQHIDVVKVLLADPKTEGIVLIGEIGGSMEEEAAAYLEVHNKNSANPKPVVAFIAGRTAPPGRRMGHAGAIISGGKGAASDKTAALQAAGAIIADSPAQIGDLMLKAMKAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3ITY0</accession>
    <name>A0A1E3ITY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030217.1">
        <property type="nucleotide sequence ID" value="XM_019177833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3ITY0"/>
    <dbReference type="GeneID" id="30194967"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37964" checksum="AAE4042765486E09" modified="2017-01-18" version="1">MRPALPAISRILSRPSAISVRSFASQPTPSPLNSNTAASPPGGPQAPLEYCSALVKKLDPEAWLCSYFWPGKERAWWLAWRAFNLELHSITTTVSQPALAAIRFQFWRDTLKTIFATNASSSNVPQHPVAVLLADMKRHRPIQRYYLSQMIDARAKALSLPPSSSTLESHLHLHSPLSSALLLGPLPVILPPTHPESAHLAHTLSHLSTLLTVVSMLRNLPLLVSSKRQINLPADLCEKHGVVEEELLRKGAEANGFRDVCWEVGTRGMDELITARQDLKSTGGKVIPSSVMPLFLSAVPAENYLQRLEKLDFDVFHQDLQKYDWQLAPKIWWRYQTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IU35</accession>
    <name>A0A1E3IU35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030202.1">
        <property type="nucleotide sequence ID" value="XM_019177818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IU35"/>
    <dbReference type="GeneID" id="30194952"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027228" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="50"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN92068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="640" mass="68682" checksum="386CC86989671D8D" modified="2017-01-18" version="1">MTSLSSAVSLAALVSLVTTEVLATPFTTPHAQLLAERGLGDKSYTPYEVSCPTTWTWEGLATVEKQYINERHKLVGPAVEKMMAARGLENPPRIPNIGVALSGGGYRAMLVGLGGVMGLMNQSQEASESGTGGWLEAVTYWSGLSGGSWATGSFMANGGPLPSSLIDSLWDLSSNLIYPSENKVSFYSELYTEVTAKQDEHFPVQVTDLWGLALGSHLLPEDYQLDNSPNFTISSLPQMIPAIANASLPMPIIIAAQREQGELVIAENATVYEFTPYEFGSWAFGSNYKSAGAFTSVEYLGTSLDNGAANGTCWKGFDQLSFVMGTSATLFNSAWLALNQSDTGLVGDLLQSILEDLGDSQVDVSRILNPFANYNTGENPVSSFEYITLIDAGETNQNIPFEPLIAPSRNVDAIIAFDASFDTNTTWPNGTAPRTTFERAMVLAQYQDVEVSMPEVPSQNGFINGGYNSRPTLFGCNRTDTPIVVYVPSFPWSYGANTSTYQMSYDNDEALEVMLSGMRSLTLNGSVETWPTCLACALTDRAFAYTSSNRSSTCQTCFDTWCWDGTDDTSEPEEYAPNIGGVPPWLTEKGLSIGVQDAPSSDTSRNSSSESGGFRVAGSVPWAMSMALAAAGVAALALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IUB8</accession>
    <name>A0A1E3IUB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000018">
        <property type="protein sequence ID" value="ODN92148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030282.1">
        <property type="nucleotide sequence ID" value="XM_019177898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IUB8"/>
    <dbReference type="GeneID" id="30195033"/>
    <dbReference type="OrthoDB" id="10600093at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10245" checksum="93B4A057117BB60F" modified="2017-01-18" version="1">MNKMPDRTVIHVQTEPYGLTSQKTLVPAAEPPQIQLSSPRHEARRGHHSESLSSNESEEYTDSTYKEPVDDRNGSVVGLGGDGDSRKGLTLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW26</accession>
    <name>A0A1E3IW26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030389.1">
        <property type="nucleotide sequence ID" value="XM_019177638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW26"/>
    <dbReference type="GeneID" id="30194769"/>
    <dbReference type="OrthoDB" id="2564910at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN92762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="401" mass="45264" checksum="334EB11B137D6DFE" modified="2017-01-18" version="1">MGDYKTQKSTIDLLVKRRLVPLGYKKRIKIRGRDKVQTSKQGVWEMRANEWALRRWPLIESLEDEGRYTTSQLLGRLHHLLLYGEAPTFEFALKLLCNASDYIADSPSVKGKERERQGGEVDVLNLYLAYAPRLAPADSLLSTFASAFPSIRLNRQSLHLSIFSLLSPPSPAAQAHQVTQKQVLAMLETFLSKDILPGLETWRHIGKFATKFGIKDLGKVGWEGWFGSLGYAEARALLGPLSYSPKSRFDGQLGADEQGAEGPESWQLRFQHLGAQKTRWARIVGRMEKKGWVQKSEAGEGRWGYVWKDAEGPVVGEVVEKREPTETKGLAESRQEKEEKDEGEGKEESKAAKGDVRKPHQRDLRTLLFRPRNPYYPRVPQVAQRHIQSLRPGAPSPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IW79</accession>
    <name>A0A1E3IW79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_05604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030435.1">
        <property type="nucleotide sequence ID" value="XM_019177684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IW79"/>
    <dbReference type="GeneID" id="30194817"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN92808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="291" mass="31663" checksum="F869ED43C9EE11B6" modified="2017-01-18" version="1">MACSISVILYNKYVFSSLNFPYPTFLTTFHLTFSAIATRVLQRTTTLVDGAKDIEMTRDRWIKSILPIGALFSGSLILSNYAYLTLSVSFIQMLKATDDDLQAFNPVAILLISFAFKIQEPNGRLIIIVLMISMGCFLAAYGEVQFELTGFLCQCAALAFEASRLVMIQILLHGLKMDPIVSLHYYAPVCAVINLCIIPFTEGLEPFYNLHRVGLLVLFSNAGIAFALNVAAVFLISVGSGLILTLAGVLKDILLISGAFLAFGSPIMPLQVLGYSISLGGLVMFKTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY01</accession>
    <name>A0A1E3IY01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030602.1">
        <property type="nucleotide sequence ID" value="XM_019177449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY01"/>
    <dbReference type="GeneID" id="30194575"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="129" mass="13513" checksum="584372B0C16C202E" modified="2017-01-18" version="1">MVFGQSDSEAAQQHITPNVFKSDADQAKEGVQQDVRHATSGTHHQAEDAIRPDAGGITSALKPSGEQSLGEQAQQKAGQIGSEVQPNDTKSATRQTKDFVTPGNDSAGAGGILNQIKNKVTGNEHKGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY29</accession>
    <name>A0A1E3IY29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_05602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="AWGH01000017">
        <property type="protein sequence ID" value="ODN92806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030433.1">
        <property type="nucleotide sequence ID" value="XM_019177682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY29"/>
    <dbReference type="GeneID" id="30194815"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN92806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="247" mass="26323" checksum="D97946379FD205D1" modified="2017-01-18" version="1">MVYSGNFKMNGSLESIEKIIKGINEAKLDGSAEVVVAPPALYLLKVQSELSPPAQVAAQNAFTEASGAFTGEIAPQQLKDADVHWVILGHSERRSLFGDTDNLVADKTKAAIDAGLSVIACVGESLEERESNKTKEVVERQLEAIAAVIDADAWKKIVIAYEPVWAIGTGKVATPQQAQDSHDDIRQWLAKRVSQSVADSTRIIYGGSVNGKNSGELAQAKDIDGFLVGGASLKPEFIDICQASKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IY84</accession>
    <name>A0A1E3IY84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_05434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030672.1">
        <property type="nucleotide sequence ID" value="XM_019177519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IY84"/>
    <dbReference type="GeneID" id="30194647"/>
    <dbReference type="OrthoDB" id="2578214at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN93567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="102" mass="11693" checksum="DFDDE07DFF184F6A" modified="2017-01-18" version="1">MIVTHTSTNSAPLSPHTVDVLTTISSCLRHVAEEAQATDDLEDRVGELEDESRRRQVREAAWEERLRRLEEADTSGGDGKKRKKKKEDLDVSKDERVSMRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3IYB1</accession>
    <name>A0A1E3IYB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PP2Cc protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_05279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000016">
        <property type="protein sequence ID" value="ODN93415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030520.1">
        <property type="nucleotide sequence ID" value="XM_019177367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3IYB1"/>
    <dbReference type="GeneID" id="30194492"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN93415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="383" mass="41561" checksum="9E0138BCECAA373B" modified="2017-01-18" version="1">MDKGTYKVPLTSPKIVGSYSSRGYREQEDASSVHALQLDPAELQQSLAKSKNPVDWNPEVAGSNFLASQAGYFGIFDGHGGPQVSSYVASKLQSLIESAEPSSIASVVEWTKEKHGGYFKRWRGGALGRWTRFAQEGQAASVENGDKMTLEERLTLAFLQADKEILEDVNGSERCGSTASVVLLHSLDGPAQPYWGAKKVAVTIGHCGDTRALLCIRATGQVLALTEKHHAESRVEASRLRRMGAGLLVSDSYGESRWMGAVENTRGFGDGQWKPSGVTAEPEVSTKVIDGDESCYIVLATDGITALMSDQEIIDLARRSLDPSRAAKTIVHFAEDLGASDNCTCVVVPLAGWGKVGGEDKTAERREYRRKNAEGMNTRMQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J0M9</accession>
    <name>A0A1E3J0M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_05231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000015">
        <property type="protein sequence ID" value="ODN94372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030903.1">
        <property type="nucleotide sequence ID" value="XM_019177322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J0M9"/>
    <dbReference type="GeneID" id="30194444"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="236" mass="25392" checksum="51832DDE624A6045" modified="2017-01-18" version="1">MFANSLRQGLRTASRSSGKYPQRPNRSSLTPPKARAFSTLPARAAPRANIGAGLAAGAAVAGYAFYESTRSPVLLEGPKTIAGEKGTVSERSFVMIKPDGVSRQLVGKIVSRFEERGYKLVAIKSLTPSPALAKEHYADLSARPFYGSLVKYITSGTPVVAMVWEGKDVIKQGRRIVGATNPQDADPGSVRGQYAVSVGRNLIHASDAFDSATKEIGLWFAQEELSDYEPWVMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1C9</accession>
    <name>A0A1E3J1C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019030911.1">
        <property type="nucleotide sequence ID" value="XM_019176879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1C9"/>
    <dbReference type="GeneID" id="30193983"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN94632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="241" mass="27131" checksum="42FF969770FCA816" modified="2017-01-18" version="1">MKTTRPTKKLDYRNDGPFRVLTKISDYAYQLDIPPSWQRFDIFPVSLLRPYTPPHFPLQSSTPSSPTPPALDHDESIPSYRIAQFLNSRNNSETGKLEYLVEWDGLEGTAEQVSWQPPSDLSSDPRFAQAKEEFHLLNPTKPSTDTTPRPKLNRAKPKTTSSAPQDDFSPATISQISHPISSHPTSSPTTLPTPNPIRPKQPPNWKGWKLVPDEPSPSSSLPYDGPTSRSGRPLRRKFIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1H5</accession>
    <name>A0A1E3J1H5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L198_04884</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031019.1">
        <property type="nucleotide sequence ID" value="XM_019176987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1H5"/>
    <dbReference type="GeneID" id="30194097"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODN94740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="432" mass="47204" checksum="23D4A6B174AE9884" modified="2017-01-18" version="1">MSLFKIAPGVQSYDWGKKGSSSLAAQLGTTSIPDFKIDESKTYAELWMGTHPTLPSKLSDKTLLADHIKAHPELIGTQVSSKFEDCKDGSLPFLFKVLSIGTALSIQAHPDKPLARKLFDERPDVYKDPNHKPEMAIALTPFLSFLNFLPLPVLLLHLLTVRELHPLIPGSLTDALAGSLNLPTTLPPDAALFKPLDSSPTPEQKNILKDIFGALMSADKGTVKEAISRLVARYEKKEDIAENEKDLVDLTLMLNEQYPEDVGVLCVFMLNVVELKRGDAAFLGANEPHAYIQDIIECMATSDNVVRAGLTPKLRDVDTLISMLTYEAAPGDKQLLQPTPFQEGDKSTLLYDPPIAEFSVLRVDLGKEGGEAKQRAVEGPSLAVVTEGKGVVSDGGEKIEFERGNVIFIGAGKEVVWESKVKVEVFRAFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1N2</accession>
    <name>A0A1E3J1N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L198_04934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031069.1">
        <property type="nucleotide sequence ID" value="XM_019177037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1N2"/>
    <dbReference type="GeneID" id="30194147"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODN94790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="182" mass="20899" checksum="4010C9B615AD0E92" modified="2017-01-18" version="1">MPIFTDVITGDELFSDAFPVKEHRSIAYEVDCEMMDQEGIDVDADLNGEGDSSPEEDTKVRVNNVVQAFRLQPTVFDKKVRNCLMISRSYFSCLKSYLTLLKAHVESTSPERVPTFEKDFKELVKTISAYFKDFEFFVRESDDPDGMVALLSSTHDPYNDYRANGVTPFFTFWRDDLAQVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J1Z2</accession>
    <name>A0A1E3J1Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_05000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031131.1">
        <property type="nucleotide sequence ID" value="XM_019177099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J1Z2"/>
    <dbReference type="GeneID" id="30194213"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="96"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN94852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="387" mass="43196" checksum="F92DAFAD8BFD008C" modified="2017-01-18" version="1">MAATTDPGSASSSSPLVPGESAYHESSQFRHWRFSSTGLHHLRQDLNRRSIEVAKKNNELEKHAQDELKGDWAQASTPAAYLTVADELCLVRFYCQQISQICRRGFALPEQVEATAISYLKRFYLKNSVMEWHPKAIMPTALFLAAKTTNYPVAIEDFLPKMPGRTQDSILGKEFLVAQSLGFEFWDQPRPPIDDIQKAVTKALLKLTESYSTDAEFIYTPSQIGLACLRMADRNLVDAFLELRYSTAAASTLQTGSDEEQPAPLYGIEKTRLIEILEKIAKMIESDGRELGKDDVKPVDKRLKGYTNPEKVPGTALYEKRKREKEQSEAAAKAAKNLKSKASDADSDMFFGGALPSSVTKENKSRIPLSPKLDINGNQQPRETNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2B0</accession>
    <name>A0A1E3J2B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000014">
        <property type="protein sequence ID" value="ODN94805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031084.1">
        <property type="nucleotide sequence ID" value="XM_019177052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2B0"/>
    <dbReference type="GeneID" id="30194165"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN94805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39908" checksum="120EC088875352F8" modified="2017-01-18" version="1">MPKQVKKPDDLYTTEVLTADAATGPSSPDIDEKGEKCDGYVEPSEPVDVDEAKLDDFINRDERYDWDSEEFRDIPEVVRNTVSFEDDPTLPVITFRAILLSAIFCTIGSVISQISYFRTTTAAFPVFFVILASHPLGKFLAKVLPAWTLPLGRFSFNLNPGPFSVKEHVIIGIAANAGSQGQWATFLPTNAALYYNITMNPAIALFFGWGSALLGFSFAAMVRPILIDDPKFVFPLSMQQVTVYRSIQGTSELHLGRSQKQMRVFWIIFAVMFTWQFLPEFVFPFVAALAPLCWFAPHNHKVNFLGAGRGGVGLLNITLDWTNITSTVITYPYSVQITIFASFVIMVSSFHSLRNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J2V1</accession>
    <name>A0A1E3J2V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L198_04561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031154.1">
        <property type="nucleotide sequence ID" value="XM_019176679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J2V1"/>
    <dbReference type="GeneID" id="30193774"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="95"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODN95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="495" mass="55425" checksum="53FCA103760B1210" modified="2017-01-18" version="1">MSLNNPSHLLISRNPPRSPAHPQLDPTLTSRHPGAASSPPATTLGRWVSDDTFTGQRPSGTYNDTTDDEYEESESEDEGPIEVHPTFQKGAELPGRVKVVVGRSEFWCHKEVLWFASPFFEGLLLGNWAESKPRPPSPTLAPPLNPPPDTDGTPSLRGSTGHEQAIDQESETRDRSSVYHDPDDQAWRLHSNFDQLAVDPSCEGLLSVSQEESPKPVSPANTPIRTPRRARDTVALRASFSSSLHPPRAVPDRPASDSECAIAEVELHEEKASAFQDFLYWAYPHLECKVTWTNVAPLLSLSTKLIVPTLQKQCSRFLLTHASGRPVMALALAEQYGNAGLFREASRFVLDQRESTWDEGEMNSLSVETQLKLSNRRSWFLERLLKLGNIDVKKEYSCRPDCPDPQRCQLQLDEKWRQAHAAVSRYGPPQPSVAFRCLRQLETFPTNPSLSMPHALCQGAAKSWVMSLFDRMFQLKIVVSANPGTEKYWLWISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J320</accession>
    <name>A0A1E3J320_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000013">
        <property type="protein sequence ID" value="ODN95244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031224.1">
        <property type="nucleotide sequence ID" value="XM_019176749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J320"/>
    <dbReference type="GeneID" id="30193845"/>
    <dbReference type="OrthoDB" id="2581067at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130100" evidence="1">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN95244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="193" mass="20508" checksum="032B7EAA5DB753D0" modified="2017-01-18" version="1">MFLLAWVSLLFLPFIAASSVSTIYWPVSHPDPNNPWVIGENNPLAWKTGGGTGVQSFDIQLHNANKTVMVGFLPIALRVPMKRVNRVYGGSLEVELDSGVPTGDGFFLVFMNTYHGQVYGKASRSLHSKKFSILDATPSNYTASALPTGTVTATLDTVPNPTQQWAITLDGIDADATATASATNYAGNAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4H0</accession>
    <name>A0A1E3J4H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_04360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031407.1">
        <property type="nucleotide sequence ID" value="XM_019176479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4H0"/>
    <dbReference type="GeneID" id="30193573"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009130131" evidence="7">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN95742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="369" mass="40552" checksum="3EC5B9D47D8DEF6E" modified="2017-01-18" version="1">MRFLAVLCLFAALTVGTLAWTKEDYEIFDLVSALETAEGKGVNFYSHLSIPSSATTQQITKAYRKKSLELHPDKNPGVKDIEERFARLGLIAAILRGKESRERYNFFYKNGVPRWRGTGYYYARYRPTLSHTLVFLVLLSNLFHRLVLQLNFQKHRARISYFETAAKSAAGVLSGSGKGGVDAGAIQGRRRKVKVPMVEGNDYSGTLELIVSGDHVYLPQDDGHLTPISTLAPSPSFSQTWLPSLALSLARRAVSHLPPSIQESLPAFLRDEEGAEADELELDDEEDEEAESEVGRGTPTPMGRASRRALQKGKGHTGKGSKNNTPKDSPAGTEAESDIALDNEAPKKKKKPGLGKAAAMRQRKLAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4J8</accession>
    <name>A0A1E3J4J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_04390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031437.1">
        <property type="nucleotide sequence ID" value="XM_019176509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4J8"/>
    <dbReference type="GeneID" id="30193603"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN95772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="431" mass="46829" checksum="EC183242054C8B24" modified="2017-01-18" version="1">MPTVNQQHPSPVGGSKDDLDKSTDLGATIDVQAVDFDPEALTAQKQTKRHLKPRHVQMTGISGAIGTGLFIGVGTSLSKAGPLGLFLAYTSNALLVFSTYNAMGEMVCWLPVDGSIVVFAHKYLDDAWGFSLGWLYFIVNALAVASEVSAVAAIINYWTDAVNNAVYVAAVCASLVGLNIFGVHIFGEGKFYFSLFKVFLIMGLLVMTFITMVGGNPEQDAYGFRYWKDPGPFVEYLARFLASGAFLYKQHTPMYGGPDFVALAAGETRNPRRVLPSVFRRVIYRLMVFYLFGVLAVGVLCPSDDPDLISGGAGAAASPFVIGVKRLNIPLPDLINALLMSSAWSCGLELFYGSSQALYSLAVDHKTPALFRFTWRGVPTFCVLAVSAVSLLAFMSASNSSVEVFTWLTNIVGSGILLQYIIHHIIYIRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4Q6</accession>
    <name>A0A1E3J4Q6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_04466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031513.1">
        <property type="nucleotide sequence ID" value="XM_019176585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4Q6"/>
    <dbReference type="GeneID" id="30193679"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="11">
        <location>
            <begin position="60"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN95848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="521" mass="56388" checksum="1D9442DB46AB8605" modified="2017-01-18" version="1">MASLGPSLYALPHTPLPSNSRPSPTLHEQRDTEHLIKQLIDLTADPAVPTPDTTKQYPTLRKAEHTQFLASSFFQLPGKFVSLDASRPWLVFWTVHSLDILGVALDQGTKDRVVSTLLHFLSPLGGFAGGPANSQLPHLLPTYASVCSLAITGNAGPNGGWDHLVSARQGIYDFFMRCKRPDGGFVVCEGGEVDVRGSYCLLVVATLLDILTPELLYNTDKFIAACQTYEGGFACSSFPFPSIIPSASAIPTADPSARAPMSEAHGGYTSCSLNSHFLLTAVPLPSFPAPIDADAALRWTVLQQGEAIEGGGFRGRTNKLVDGCYSWWVGGGAPVAEELVRRERSKKAKGQAKKLEVLDGEEQESDWEDVAPSPSVFNRVALQEFTLIAAQQDAGTTGGLRDKPGKRPDQYHTCNNLSGLSIAQHNLVHSPSTIAANRAEFDPSKGLPAVKTSTPEGGWKSEEERQEARRAVWASALGWTVEGSEVVVGGKDNRVNTTTPVFNLLNLRLKPFINYFYCQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4R1</accession>
    <name>A0A1E3J4R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_04445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031492.1">
        <property type="nucleotide sequence ID" value="XM_019176564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4R1"/>
    <dbReference type="GeneID" id="30193658"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN95827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="319" mass="34248" checksum="6E1B08DF9421D6B0" modified="2017-01-18" version="1">MSVASLAGPSTDKAPNLLSYPKKLVQTLEHQGAVNVVKYNHGAKYLLTGSADRTIRLWNPALGKEIKCYRGHAQPVLALDIAQDNAKFASSGVDKAVFLWDVPSGAVTRRLQGHFGHINAVAFSQDGQVLASAGFDAKVMLWDMRAASRDPLQTLKEATSTITSLILPTSPQVITGSADGFIRTYDLRFGLLTEDLIGTPISSLKLSPTAPEESVLVGTNDGKMRVFDRKDGGCLQTFEGHNVGGKTGKWGTEWGYGDGLVLAGDADGKLWAYNVLDARPIDTSPTPIHKKTITNIQLHPKGKEMITASADGTVKVWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4S3</accession>
    <name>A0A1E3J4S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L198_04478</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031524.1">
        <property type="nucleotide sequence ID" value="XM_019176596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4S3"/>
    <dbReference type="GeneID" id="30193691"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="377"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="726"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="981"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODN95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1163" mass="125542" checksum="9244847217A4036F" modified="2017-01-18" version="1">MAYVAVAKALYDYAPQDPESELAFSEDQILYIVDKEDDEWWKAKLKEEGGGGAEGGVGLVPANYVEEIPPLSATRAMFAYDSTSPEELSMTDEATLHVFSIEEDWLLVRLESDGTAGKLGFVPRNYCEPLEESEGQVEVADAREAEEEMEAQRQRELQEKQRQLKLKDKVETWSISELDGKKKKKGTLGVGNAAVFFASDTDKAAPVKQYPITSLLAVSQPSSKLLSLSLDSLPQPLDFHCGSSDTSKAILAKLEQSKEAAGEALELLNAEAGQESEEEEEPVPAAPPVRNVQEPKAVRFASSPSPSPSPAPPSRAVASESATVLYDFDAAGDDELSVQENTTVEIVDKENEEWWLVKDSHGQQGVVPAAYLQLNDGSAPAAPVEDDSAAQAIAAQAQADAEARRQADAQAQRAAAEAERKRIQAAAQERQRQEEEDRELAAQIEEEQKERAARKALKRQEEERRKRQEEAQAARENARSGGLQPPQITKRPSDNDVALAASRLPTRTASSAPAPRPPPEQSRPKPNPNKIRTWSDKTGQFNVEAEFLGVHAGKIRLHKLNGVIIDVPVEKMSARDSELIKRHEAKRAKAASAADDDRPLGQQSRRVRSHESTHRADEPIPADVMRASKASASTRRSTFDWFEFFLSAGCDIDDCTRYATNFERDRIDEAILPDLDNGTLRSLGLREGDVIRVAKAIQGRYAKKDPELQKQIDADAEYAKQLQEYDRNGSKGPAPQAPPGLFTGPNGKLANNTRRGRPEKKSTGPESVDAAALAAASDKLNKVSLTPTPPSAPTPPPVTVSPPVPAKKEEEKPKAAPSGFDDDAWTIKPLSSKPASPAPATITTSISPPPAPAAPPATSPSVANNTDSLLAQINNLRPASTGVSVSNQNTGGSFGQQTPVQQQQPQAPNAYGLGVQNASQPLNMLSQPTGASPHPTTLNSMATGGQGPRGPLAPVSANQNLLNPMQPQATGMFVPTRGLSPMQSQQTGWQQPQPTGMPQQPQQTGMMPQQTGYGGYGGMGMQQNFTGMPQQQSSFNAIASIPPPQPPQQSGGGDKFAPSNIFAAMKKTDFTKPEEQRPQEAGKYDALRPLATGYNGGMMPQQTGMYPQQTGMYGQQTGMPQQQMQQGMVQQQTGMPMGGMMPQMTGWNPNGGMYQNQGGYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4V0</accession>
    <name>A0A1E3J4V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L198_04486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 7118</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031532.1">
        <property type="nucleotide sequence ID" value="XM_019176604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4V0"/>
    <dbReference type="GeneID" id="30193699"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODN95867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="365" mass="39993" checksum="FB340A4F7F804248" modified="2017-01-18" version="1">MDPRRRNNQPPQQSYPPNPSGYNRGPPPPQDRYGSSYNESRSYPPQNGGYDTPPQSYRGPPPPQSQPVYGGAGGGGYPGNARDGNYPPNMPNFPPRDTAEGGFRPHDPRSRYSGAQASYNTPTPPPGQTPPHVGYGTPPTAAGALAPQRAGTGTPLSNGVKEEAMEEHTPGGMRRPLFCVVCASNNNRSMEAHHVLNQNSFRVISAGTGSAVRLPGPSIDRPNVYRFGTPYDTIYNDLMSQDPALYTRNGILPMLDRNRKVKRAPEKWQELRRVGADVVITCEERCFDAVCEDLLQRGGEYNRPIHIINVEIKDNPEEALIAGKSILDLARAIEASKDVDADIDHILNVQADKHPHTLLHTVAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J4V7</accession>
    <name>A0A1E3J4V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L198_04503</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000012">
        <property type="protein sequence ID" value="ODN95884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031549.1">
        <property type="nucleotide sequence ID" value="XM_019176621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J4V7"/>
    <dbReference type="GeneID" id="30193716"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="16">
        <location>
            <begin position="155"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODN95884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="309" mass="33910" checksum="8CADEF75B72D350F" modified="2017-01-18" version="1">MSEQETATAPIPVVPVTASAVAPAWPELTPEHPLLQFHSRLATILSTADHSQIWGVTLSAATPPQFSTLLILQKYLRSVSGDVDAAAAALEKTLQWRKEFGLDKPEGEKREEFGSELDGLGYVTKVKTSEGKDEVVTWNVYGAVKDFKATFGDLDRFLKWRVHLMEETIAHLHLSITSTPIPDFSLTSPQADPHRIAQVHLYEGVSFLRMDPHVKAASKATIELMTAHYPELLSRKFFVGVPLVMSWMFQAVRMFVSAETAKKFVVISYKTNLAAELGEKDGVPVDCGGTGPALAELQTALVKADPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6D9</accession>
    <name>A0A1E3J6D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031679.1">
        <property type="nucleotide sequence ID" value="XM_019176269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6D9"/>
    <dbReference type="GeneID" id="30193360"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="82" mass="9675" checksum="99A319ACA762A644" modified="2017-01-18" version="1">MVGLFSTSLLSGCLLSPKSPRLPFNHSCRGRTPSQKTFIVKQKLAKKARQNRPLPQWFRLKTDNKIQYNAKRRHWRRTKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6M6</accession>
    <name>A0A1E3J6M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_04238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031769.1">
        <property type="nucleotide sequence ID" value="XM_019176359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6M6"/>
    <dbReference type="GeneID" id="30193451"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN96523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="550" mass="58954" checksum="FB36067C25A06D74" modified="2017-01-18" version="1">MLHTPIPLRLSVNKRRFHLSPRTPSFTFNPPATPSLPLSGTSFLPSPAAPPSPALGLSHSPRKRPSTPTSASSPVAPAHALEAGGSRIDCQRPTKRIRSLGNEDKGNHKGPLGLITITGTSVEHGKMEDIEMREDGDNVHIKTGDEEESFGNVPSYQARTIGKPFPTAQSGLPQSTPLFPPLPALAMRRSNPKKLSLSLPSSSSSSTSSTPTATGPSDSSFPTPFTPGPPRTPALAMSTGRSTTRGLRRPSLLSLITQPPSGDAVPPTPAVGMHPYATMHMPRSKGRARSQTAEEIFTTRPENKGGSWSATPLGMGMGVPTIEETEGSSLTTSGLNQLGYALPSSSPQKPASDSSSTTSFSASTNTTPSTSPPLPASFSFSKPYPVRQAEPYEDGPIEVVPGVWLGAEESAWRFDVWAVGKSKVRIVNVAQEIDDPFDLSVRAVPGWSGTGSEKKGTMKLKTYPSISEGHAARPEVEYCHVRWSHGELGLADLPEKATLGDVRRPQGPEVQDMWKFWQAIRWMEEGRKSGTPVLIQRVSISYKWVKLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J6V4</accession>
    <name>A0A1E3J6V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein Musashi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L198_04305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000011">
        <property type="protein sequence ID" value="ODN96589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031835.1">
        <property type="nucleotide sequence ID" value="XM_019176425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J6V4"/>
    <dbReference type="GeneID" id="30193518"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODN96589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="464" mass="48830" checksum="FC47A1C5CBB739B0" modified="2017-01-18" version="1">MADNINDLYGDLDLEDLDASQLEELVEPPELDVAPSSTPALSHTSQPAPAQPQAQSFSQPSEQPAQQHQFGYNSFDQQQQSDGAGDRIKPSDMPDEGKMFIGGLNWETTEDSLTTYMGQFGEIDACTIMRDPSGRSRGFAFLTYKSPTSVTKVMSQPHVLDGKQAGRLFTPLTGLTSPQIDPKRAIPRAEHERTAKVFVGGLAPSVTGESLKSFLCQFGQVMDATVMFDKETGRSKGFAFATFQDEDSVGRAMAASGIELEGKAIEIKKAQPRGTAQGSRSTYQQNRFGGNQPNAFGGGMGGGFNGGGGFDPNSMAMMYQNMMKPAGGMGNMMGGFDPSAMAMMYQNMMKSMGGGNAPAINPNMAMRSPNDSVSSGAAPGMNNMMGMGMGGMGMGGMGMNMGGMGMGMGNMMGGGMNRGGMASRPPNAPRGPAAMRGPQQGGVTPQGPGAQRYSTQGNARARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J968</accession>
    <name>A0A1E3J968_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032005.1">
        <property type="nucleotide sequence ID" value="XM_019176092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J968"/>
    <dbReference type="GeneID" id="30193180"/>
    <dbReference type="OrthoDB" id="2574021at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="192" mass="21227" checksum="1FD3D87D77F9CF30" modified="2017-01-18" version="1">MKTDFLKIQYQQGIDYYAVLGLEEGASPAEVNKAWRREVLLHHPDKNPSLVIPSSSTGVSGASTPSGSEEQNAKIHLINQARLVLTDPVLREEWLSSFLSNAQQPQKPKEEGPHVFRHISLDEFEPCYASTTSGGTGEAEDEEEPTHFVHPCRCGGEFLITTEQLDQGVDVVGCEGCGEWVRVGYEVVEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9B5</accession>
    <name>A0A1E3J9B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L198_04017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032055.1">
        <property type="nucleotide sequence ID" value="XM_019176142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9B5"/>
    <dbReference type="GeneID" id="30193230"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="340"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="732"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1025"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="948"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODN97453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138587" checksum="4236E86BD2447AD4" modified="2017-01-18" version="1">MAPEIAQAAFAAVPSSLVEIAKNKTQPLYRYVSKKLGKEYQPILAHDDELDVDTVAVEVPEAVPQMPSGGLLSDLKNHVKSMKEYGSVLFALEIFRTLSLCALFGLSVYATIQAESPQEPGLEGGMVESLKRKKKGNHHHTVDDYSSLEWGEFGVSGLYLYSLAFSFLLLTLRPGTPLRRHLIAHLDVLLLLAFGVYAYRDIWPLLTSHLEPADIHNAITWSRVVILSFAAVVIPLIRPRTYTPVDPSNPTPLNEVHPEQTAPLLSYLLFDYMTSLVWKAWKTPALPYDDLHPLADYDRASYLYKTSMATLDPVKRRAQGLKDRGLVLSLASVFRREVMITCALSAFSGAFELSSSVGINQLLDYLETDGKGHNVRPIVWVVFLFMGPTLSSLFMELYIFTATRCLVRAEALLTQLLFDHSLRLRMKDQVDDEKEEEEEGKESAGPLITVEEVDHAPDAPRGLIAAEAETATPAESQTGKDKTDRKAAADAEAKKSKGQGLAGKINVLMAADIEAVGEGRDLALIFVYTPVQFALCVVLLYKILSWSSLVGMLTMFITLPLPGLLTKYNAEYQQQRMLATDSRVDSITESINALRIIKMFGWEGRIKERVAAKREDELHLIWKRRLMNLAIILLNTLLPVLTMAVTFAVYTLIEKEELTASKVFTSMTVFEIIKGHTGMCFWLINESVTAWVSVQRLDKFLHESEMIDEYSQGKMTNIVTQSQLQAQEENLIRLVDATFSWESKTEKINDETFKLHIEDATFTKGKVNLITGPTGSGKSSLLKSLIGELHFHQRDGAFYNLPREGGVSYAAQESWCSSDSVRDNILFGSPFDQSRYEKVVRACGLETDMKLFEDGDETEVGEKGITLSGGQKARITLARAIYSKSAVVLLDDIFSALDTLTSRWIIDHLFKGDLVNDRTILLVTHHLHLVAPVADFIITLNENGTVQSQGPVNENALPEEDEPETEAAPPAEEVKNPDEAQKTAEKKAASKLVKDEEKSEGRISKHAFITFFRMFGGPIFWLTYFGLLFGGQAMSAFQTYWLGRWARAYEESSDANLVSVSYYLGLYFVFVLIGVVMGGASAILFYLGCTKAAREMHRRLVDSIFGAYMRFMDTTPVGRIISRFTKDIKSIDGPFTETFDTVADVTAGLILKIAVVVSLVPLFSIPAVIIGALGGIMGEMYIHGQLSVKREMSNAKSPLFSHFSAAFNGIVSIRAYGAEEQMRLEAQRRADKYSRAATCLYVHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3J9M9</accession>
    <name>A0A1E3J9M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031977.1">
        <property type="nucleotide sequence ID" value="XM_019176064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3J9M9"/>
    <dbReference type="GeneID" id="30193152"/>
    <dbReference type="OrthoDB" id="2567277at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN97375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="251" mass="27329" checksum="C676D86F396B33D6" modified="2017-01-18" version="1">MGRGLDPVWEFYYRIDQDVHSLGLKSKANTAHNNGWCRNCVRATVTQLLNWQPDHQLLVEAGNEETARRYKAMSELTPLTGVPSRLRSHLMKCPHSRHVEIPPASVQKRKTKGGDGASGSRHNLSGTPTKGGKFTADGKFGEEEQGEFNVHLYHLFVALDIPFDLVSNPTLQQFVNRYIPGAGLPSRSLFYTLNASRSMGSTAPTLSAAQGATGGSPDFQGLAKLAANFAAVPMAGVGEQETEEGEMAYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBG8</accession>
    <name>A0A1E3JBG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L198_03824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 7118</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="AWGH01000010">
        <property type="protein sequence ID" value="ODN97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019031863.1">
        <property type="nucleotide sequence ID" value="XM_019175950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBG8"/>
    <dbReference type="GeneID" id="30193037"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="167"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODN97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="342" mass="36463" checksum="5F0DBC82C796B1D3" modified="2017-01-18" version="1">MAPKQHAHLLALARAMVPPLHPKLHKGQAGRIGVLGGSGDYSGAPYFSAMGAMRFGADLAHVICEPSAGAVIKTYSPDLIVHTILDPKNSDAEIKEAMKGILSRLHVLIIGPGLGRDEHMQNCGRIAFELARDMDQMGVVVDADGLWLVQAMVMGWPGVPRIILTPNVMEFKRLCEKMEIDPKASPETLCPKLASALGNLTIVQKGPTDIISNGLAIPSSLLPDEKDKQEILENTVEGGLKRVGGQGDILSGSTGVLLAWGSEWVRGTYESVGHPPPEDKSIAENVPLLAAYGASTFNRTVSKHGFAKKGRSMVTGDLVELVGPVYEELFGKPGENEGVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JBJ6</accession>
    <name>A0A1E3JBJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L198_03485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032105.1">
        <property type="nucleotide sequence ID" value="XM_019175615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JBJ6"/>
    <dbReference type="GeneID" id="30192698"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="59"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODN98243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="584" mass="65077" checksum="3B6BE643CABB15F2" modified="2017-01-18" version="1">MASIRHIPRLIARAPIRPICATRIRTLSPIRHYSTPTTTAPATTSLFTPPGDPATSKPFYVTTPIFYVNASPHIGHLHSLLLTDVLARFSRLRHPERKAMFATGTDEHGMKIQQAAMKMGVDEQSFCDDVSQRFRDLAELVNTSHTDFIRTTEPRHQKAVEHFWNKLVESGDIYKGTHAGWYSVSDESFYAASQVTKRESDGKMVAVESGNEVAWEEETNWKFRLEKHRQYLTEWLSQPESVHPNPVRLNLLKQIPTLEDLSISRPLSRVKWGIPVPDDPSQSIYVWVDALINYITVGGFPGGLEGWPADVHVVGKDIIKQLTEATRFHALHWPALLHSASLSPPRRIIAHAHWTMDHSKMSKSRGNVVDPIGAVGQWGVDGVRWYLMRVGGSLADDAGIDYAPDQLEVHYRLLASQIGNLLSRLSSPKILNKATAPFSSESDRDAELDGLLGGMRGEFERKMEVYGVGPACVGVMDVIFAANKLFTDLAPWSPTTPSSTKAVTYAYHSLRLAFILLQPIIPGKAGEGLDRLGVPGERRGWGDAVWPLEAEEGQGELVERMKEAGKRWKKKGVLFPLPAKEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JC26</accession>
    <name>A0A1E3JC26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L198_03648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032266.1">
        <property type="nucleotide sequence ID" value="XM_019175776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JC26"/>
    <dbReference type="GeneID" id="30192861"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="44"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODN98404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="744" mass="80630" checksum="6FF3D43C85263A73" modified="2017-01-18" version="1">MAFADQFAVPAYILRHFDISASPWIDDSVAGSIEQRRHSSPGKKLFYDRLLDIAGINGPSVYPPRNPADIRRLLHSIDSTDLDRLKKDCYFYYLLKDFDAQPKAVVVNGYGEGDEMDLDSGALVRPGDEQVVGRAVQFAKKRCMPSQWRLFIDGYWSLDHGLWEDAVGSLSDPSISEINFIPEIVKALSSSVSTPRLASALLHSLLLTTQTELPFGTPENEISVVATASAASLSEAFAIIRRAPDAQDQSKLREAVWCWALGAPKTSCGQGSHPVQPKALRELLHIPLLPSEETHLIDFLSRPSRTITTTAISQLHDLVTLRLIHQGNYSQALQLDKQLAGSAGKQEDKERRSEIVRGFISVLPEVHRRVLLADLESGAGKQMVNGNTEDVDMGWTDGIVDAPTSVSTPPVAVPAQPFASTPVRSASSSSLAHISRAAPQQASPAPERVSSPFHGPPRFAAAPDPSTSISSPRQTQAFSGSPFSLPPKSAAALAQKAAQEKKVLPKTVVNDDVEEEEALLRGSVRGKGKPSAKQGEIRRSARQSSKSLEPEELDENHPIEPIAEDIPWSPPAETLSRSTKRASSIRRETRATVSPPPVPSARRSTRARQSVAAVEDDAPPARRTRGASAHPEPPTPARSRMTRSVSRALADFSDDESVPGLPPRSTKKTAPASTRKKRRGSVAASEVTEDGDRATELETPRAKRTRRNVASPTPSAAGSEVGKGRKTKEVATRTPRMATRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JCW5</accession>
    <name>A0A1E3JCW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L198_03771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032387.1">
        <property type="nucleotide sequence ID" value="XM_019175897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JCW5"/>
    <dbReference type="GeneID" id="30192984"/>
    <dbReference type="OrthoDB" id="10413719at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODN98525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="186" mass="19633" checksum="CBDEBC26B401AA5C" modified="2017-01-18" version="1">MFSSFDRADDTSILGTGALFRDSPRPFDSAADDDDRRGSTDSMASVKIEDSQRPAATMYATRSTNKKKRSSMPEPPVPAAQQSSASSKGKGRSSRTPTGPSNADEDEHQSLSPPSGSKGKGKAGSHPPLTGFTSVENDDASHHPLCLQITPTLPSFRVPDADVLRLIASGSRLPGEKAPHQLTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JED8</accession>
    <name>A0A1E3JED8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L198_03514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 7118</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032133.1">
        <property type="nucleotide sequence ID" value="XM_019175643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JED8"/>
    <dbReference type="GeneID" id="30192727"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODN98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="49" mass="5618" checksum="263A4482F972D9D6" modified="2017-01-18" version="1">MAETILPLELIDKCIGSPIWVLMKNEREFSGTLMGFDDFVNMVLKDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF34</accession>
    <name>A0A1E3JF34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000008">
        <property type="protein sequence ID" value="ODN99442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032519.1">
        <property type="nucleotide sequence ID" value="XM_019175416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF34"/>
    <dbReference type="GeneID" id="30192497"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="125"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="438"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODN99442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094819"/>
        </source>
    </evidence>
    <sequence length="745" mass="80551" checksum="79DCFB63FA1D64DF" modified="2017-01-18" version="1">MSALPSLNQSITAAWNTPAPPQQQKKRTRKAVPLNGITAPGTPVDPSISAQAGPSGEDDAQPTPPPAPRRKRPRTDPSTIAAKYTPPDVNLSLLGGLQSQITQLLEIVALPLWHPEIYQHTGVPRPKGVLLHGVPGGGKTQLVRCLAGEMKLPFISVSAPSIVSGMSGESEKTLRDTFEEAKKVAPCILFLDEIDAITGKRENAQREMERRIVAQLLTLMDDLAASEEPVIIIGATNRPDSLDPALRRAGRFDHEIEMGVPTQEGREQILRVLCSKLRLSGDVDFRALAKATPGYIGADLTALTTEAGVTAVKRIFEEMTSGEREFPAPDGVENMMIDDQPFANLSADLRQTAIAKFLLSHPSPLSSDQLDSISLTPSDFLTALKIVQPSAKREGFATIPDVTWADIGALSATRDELHMAIVQPIRHPEMFSTVGIDAPSGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESERAVRQVFTRARASAPCVIFFDELDALVPRRDDSMSESSARVVNTLLTELDGLDARKAVYVIGATNRPDMIDPAMVRPGRLDKLLYVDLPSAEERFDILRTHTKKTPIDETSWGTIREVVMSDKCEGFSGADIAALVREAATLALRSALESIGAFETAAESEPLGVAERARDVRVTIEHFQRAAQKTLPSVSREQRIKYERMRDKYAGVPTRGRKQREAEAAAAEKSAKLEGAKTEADEGEGMVVDDIGGGRGGVSEKAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E3JF41</accession>
    <name>A0A1E3JF41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L198_03767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptococcus wingfieldii CBS 7118</name>
        <dbReference type="NCBI Taxonomy" id="1295528"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Cryptococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-06" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 7118</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWGH01000009">
        <property type="protein sequence ID" value="ODN98521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019032383.1">
        <property type="nucleotide sequence ID" value="XM_019175893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E3JF41"/>
    <dbReference type="GeneID" id="30192980"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000094819">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
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